diff --git a/576/InvasionFront_CD3_block4_x6_y8_patient576_1.json b/576/InvasionFront_CD3_block4_x6_y8_patient576_1.json new file mode 100644 index 0000000000000000000000000000000000000000..74a54d76f7e570ecc116b6a78aa5447b2e7f65af --- /dev/null +++ b/576/InvasionFront_CD3_block4_x6_y8_patient576_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21388.7, + "Centroid Y µm": 26436.0, + "Num Detections": 20278, + "Num Negative": 20030, + "Num Positive": 248, + "Positive %": 1.223, + "Num Positive per mm^2": 101.45 + } +} \ No newline at end of file diff --git a/576/InvasionFront_CD8_block4_x5_y8_patient576_0.json b/576/InvasionFront_CD8_block4_x5_y8_patient576_0.json new file mode 100644 index 0000000000000000000000000000000000000000..49359f37958dc8274efdbd47a79d240f3c546300 --- /dev/null +++ b/576/InvasionFront_CD8_block4_x5_y8_patient576_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 24936.8, + "Num Detections": 20655, + "Num Negative": 19625, + "Num Positive": 1030, + "Positive %": 4.987, + "Num Positive per mm^2": 414.18 + } +} \ No newline at end of file diff --git a/576/InvasionFront_CD8_block4_x6_y8_patient576_1.json b/576/InvasionFront_CD8_block4_x6_y8_patient576_1.json new file mode 100644 index 0000000000000000000000000000000000000000..27ae9ea81d5d341970431847ca2fd45d44ea11cf --- /dev/null +++ b/576/InvasionFront_CD8_block4_x6_y8_patient576_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 25011.8, + "Num Detections": 21377, + "Num Negative": 20371, + "Num Positive": 1006, + "Positive %": 4.706, + "Num Positive per mm^2": 398.52 + } +} \ No newline at end of file diff --git a/576/TumorCenter_CD8_block4_x5_y8_patient576_0.json b/576/TumorCenter_CD8_block4_x5_y8_patient576_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e52f17205112d7de79e822ac653f3c4d42eb3633 --- /dev/null +++ b/576/TumorCenter_CD8_block4_x5_y8_patient576_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 20689.0, + "Num Detections": 24586, + "Num Negative": 23510, + "Num Positive": 1076, + "Positive %": 4.376, + "Num Positive per mm^2": 393.9 + } +} \ No newline at end of file diff --git a/576/TumorCenter_CD8_block4_x6_y8_patient576_1.json b/576/TumorCenter_CD8_block4_x6_y8_patient576_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3fdc7388dab10d723de4f17c1bf712d1fb909e3 --- /dev/null +++ b/576/TumorCenter_CD8_block4_x6_y8_patient576_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 20938.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/576/history_text.txt b/576/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1e8e45ee9c68e456212f9ba142ea18923ac1a27e --- /dev/null +++ b/576/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the right oropharynx. Tumor originally described as tongue base tumor with larger ulcer. Now pharyngoscopy and laryngoscopy again to determine current extent and exact therapy. \ No newline at end of file diff --git a/576/icd_codes.txt b/576/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/576/ops_codes.txt b/576/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f79e2fd442edf2cd9338e920c86cd51783b4df0 --- /dev/null +++ b/576/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Transplantat[5-296.14 ] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme freier Radialis-Lappen[5-858.23 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/576/patient_clinical_data.json b/576/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4f7ab9555d3c967396b59b13b3b4d3ae23c44316 --- /dev/null +++ b/576/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/576/patient_pathological_data.json b/576/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f3513226f8d636096ed269ee5e6c7c8f362ec5b8 --- /dev/null +++ b/576/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "576", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/576/surgery_description.txt b/576/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..766847db459d8beb5d7ecc55c69a013b77ecd987 --- /dev/null +++ b/576/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck dissection sowie Tracheotomie diff --git a/576/surgery_report.txt b/576/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..aebe6ac1b1e442c81a45f6c16d5994bc06374fde --- /dev/null +++ b/576/surgery_report.txt @@ -0,0 +1 @@ +Entering with the Kleinsasser tube size B. Inspection of the tumor. The central ulcer is visible, which is very deep and extends towards the submandibular region and pharyngeal wall. Inspection of the overlying tonsil. Suspicious tumor foci are now also visible in the middle to upper tonsil region. Overall confirmation of the tumor with a slightly wider extension in the direction of the tonsil lobe. Therefore flap coverage probable. Initially start with transoral resection. Tumor is incised on all sides from the cranial side with a safety margin of 1-1.5 cm. The entire tonsil, the anterior palatal arch and the mucosa of the glosso-alveolar junction are exposed. Resection is performed until there is no longer an overview downwards. Subsequent repositioning for neck dissection and completion of the tumor resection: skin disinfection. Injection of 10 ml Ultracaine 1 % with adrenaline into both sides of the neck. First start with neck dissection on the right: incision in typical manner. Exposure of sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure of the internal jugular vein, facial vein, middle jugular vein, internal carotid artery, external carotid artery, facial artery, superior thyroid artery and lingual artery. Exposure of the hypoglossal nerve, vagus nerve and accessorius nerve as well as the branches of the cervical plexus. Clearing of levels II to V. Submandibulotomy is then performed. The Wharton's duct is exposed and ligated. The lingual nerve is preserved. Cut through the digastric and styloid muscles, which are knocked aside after bipolar coagulation. Then loop the external carotid artery with a vessel loop and dissect the large vessels from the pharyngeal wall. The hypoglossal nerve is completely dissected and mobilized. Then complete the tumor resection from the transcervical side: enter the pharyngeal wall from the inside and outside. Further isolation of the tumor until it can be pulled outwards through the pharyngeal wall. Resection of the tumor together with the large ulcer under visual control. For this, parts of the pharyngeal wall up to the hypopharyngeal entrance, vallecula and base of the tongue must be resected from the right side. Resection is performed anteriorly up to the pre-epiglottic fatty tissue. Tumor is removed in its entirety and thread-marked both circumferentially and basally. Tumor goes to frozen section. In the frozen section, all margins are tumor-free, thus R0 resection. Careful hemostasis and irrigation of the wound area. Neck dissection on the left follows (dictation ): Skin incision along the anterior border of the sternocleidomastoid muscle. Exposure and ligation of the external jugular vein. Exposure and sparing of the auricularis magnus nerve, exposure of the digaster muscle of the cranial accessorius nerve and the caudal omohyoid muscle. Exposure of the capsule of the submandibular gland and the hypoglossal nerve. Subsequent exposure of the internal jugular vein from caudal to cranial. Dissection of the anterior neck specimen with targeted hemostasis and then, starting in level IIb, dissection of the neck specimen with identification and protection of the accessorius nerve and targeted bipolar coagulation. Thus evacuation of levels II, III, IV and V while leaving the submandibular gland intact. Wound irrigation using hydrogen peroxide and Ringer's solution Insertion of a 10-gauge Redon drain and two-layer wound closure in the typical manner using 4-0 Vicryl and 4-0 Ethilon. Transition to tracheostomy: make a 5 cm incision horizontally below the cricoid cartilage and sharply cut through the skin and subcutaneous tissue using a 15 mm scalpel. Further dissection in depth using pointed scissors, anterior jugular vein is identified, cut and ligated, no bleeding. Now locate the anterior neck muscles and cut through the linea alba. The musculature is pushed to the side, the thyroid gland is no longer present during deep dissection, as a complete thyroidectomy was performed years ago. There also appears to be no residual tissue. The trachea is relatively ossified. After demonstrating the findings on , the 2nd and 3rd tracheal rings are identified and the pointed scissors are used to enter between them. Creation of a Björk flap, targeted bipolar coagulation and placement of 3 sutures using Ethibond caudally and 3 sutures cranially to ensure adequate epithelialization. The skin is movable so that tension-free suturing can be performed without any problems. Skin suture then with 4-0 Ethilon. A 9-gauge cannula is inserted without any problems, cannula change on the 5th postoperative day and suture removal between the 7th and 10th postoperative day. Then removal of the radial flap from the left forearm: After measuring the defect size and the 3-dimentional configuration, mark the flap on the left forearm. Then lift the flap first ulnarly, then radially subfascially. Extend the incision cranially and expose the superficial venous system or the connection to the pedicle. Then clamp the artery. After sufficient time, sever the artery. Saturation always at 100 %. Lift the flap from the lower surface. Outgoing vessels are bipolarly coagulated or clipped. Two larger veins from the superficial venous system can be visualized in the antecubital fossa; the confluent veins are very small. Deposition of the flap with ligation of the veins and suturing of the proximal radial artery. The flap is then flushed with heparin. Closure of the forearm: this is done with split skin taken from the thigh in the typical manner. Hydrocolloid dressing is then applied here. Subsequently, closure of the upper arm proximal primary. This is done after sufficient hemostasis. Sewing the split skin successively into the defect. Sew on a few swabs to ensure fixation of the skin to the wound bed. Then application of octenidine gel. Application of Mepilex. Compressor pressure bandage over this. This is molded to the forearm with absorbent cotton. Then fit a Cramer splint in the functional position. This is fixed with an elastic bandage. Attachment of the forearm. The flap is then sutured into the defect. This is splinted transcervically and transorally, partly with the sutures in place. The flap is successfully sutured into place without tension. Complete defect coverage. The superior thyroid artery is then selected for the arterial anastomosis. This is conditioned, as is the radial artery. Suturing is performed with 8-0 Ethilon single-button sutures. Opening of the clamps, good arterial flow, good venous return. The veins are then conditioned. Here selection of 2 outlets from the thick facial vein. An outlet near the outlet of the facial vein from the internal jugular vein is anastomosed with Coupler 3.0 with one of the cephalic veins after conditioning of the veins. Good venous flow after opening the clamps. Positive smear phenomenon. The other vein from the cephalic area is anastomosed with the stump of the facial vein using Coupler 3.0. Again, good venous flow after opening the clamp, positive smear phenomenon. Subsequent careful hemostasis. Irrigation of the wound area. Closure of the wound in layers and insertion of 2 flaps on the right and a Redon drain on the left. Insertion of a 9 mm tracheal cannula, which is fixed with sutures. The flap is then checked again enorally, which shows the flap to be vital and well supplied with blood. Completion of the procedure without complications. The patient is admitted to the intensive care unit for postoperative monitoring and should remain ventilated for one night. Please continue antibiotics with Unacid for one week. Please check flap perfusion directly transorally or via Doppler at the marked site. This for 5 days. As the patient requires full heparinization postoperatively, the heparin perfusor should be run according to the coagulation situation, between 500 and 1000 E/h depending on the coagulation value. Heparinization is absolutely necessary due to pre-fibrillation. Feeding via the inserted PEG tube. On the 10th day, swallow porridge and then build up the diet if necessary. If necessary, initiation of swallowing training as the defect extends to the vallecula on the right side. Overall cT2-3 oropharyngeal tumor on the right, more likely cT3, clinically enlarged lymph nodes were visible on both sides of the neck. Waiting for the final histology and discussion of further therapy in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/577/InvasionFront_CD3_block16_x3_y6_patient577_0.json b/577/InvasionFront_CD3_block16_x3_y6_patient577_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bac6d7d17a480cae978ae6453312d8ab6fd7588c --- /dev/null +++ b/577/InvasionFront_CD3_block16_x3_y6_patient577_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11679.7, + "Centroid Y µm": 19525.6, + "Num Detections": 13660, + "Num Negative": 13585, + "Num Positive": 75, + "Positive %": 0.549, + "Num Positive per mm^2": 30.94 + } +} \ No newline at end of file diff --git a/577/InvasionFront_CD3_block16_x4_y6_patient577_1.json b/577/InvasionFront_CD3_block16_x4_y6_patient577_1.json new file mode 100644 index 0000000000000000000000000000000000000000..93a79e65a58ab14bc9d61346d40492920af74bf1 --- /dev/null +++ b/577/InvasionFront_CD3_block16_x4_y6_patient577_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14303.6, + "Centroid Y µm": 19648.9, + "Num Detections": 10952, + "Num Negative": 10863, + "Num Positive": 89, + "Positive %": 0.8126, + "Num Positive per mm^2": 61.13 + } +} \ No newline at end of file diff --git a/577/InvasionFront_CD8_block16_x3_y6_patient577_0.json b/577/InvasionFront_CD8_block16_x3_y6_patient577_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cdf7c5e69479453f0dcd02c81711a8fd43d01820 --- /dev/null +++ b/577/InvasionFront_CD8_block16_x3_y6_patient577_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10903.5, + "Centroid Y µm": 14817.9, + "Num Detections": 15397, + "Num Negative": 15362, + "Num Positive": 35, + "Positive %": 0.2273, + "Num Positive per mm^2": 15.35 + } +} \ No newline at end of file diff --git a/577/InvasionFront_CD8_block16_x4_y6_patient577_1.json b/577/InvasionFront_CD8_block16_x4_y6_patient577_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4c01f157153206dfb1b7772a9bd1889c52863135 --- /dev/null +++ b/577/InvasionFront_CD8_block16_x4_y6_patient577_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13625.9, + "Centroid Y µm": 15009.8, + "Num Detections": 12295, + "Num Negative": 12280, + "Num Positive": 15, + "Positive %": 0.122, + "Num Positive per mm^2": 9.986 + } +} \ No newline at end of file diff --git a/577/TumorCenter_CD3_block16_x3_y6_patient577_0.json b/577/TumorCenter_CD3_block16_x3_y6_patient577_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d886737de096723e1d640fbeafe3962de5e841b0 --- /dev/null +++ b/577/TumorCenter_CD3_block16_x3_y6_patient577_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11768.8, + "Centroid Y µm": 15441.8, + "Num Detections": 13211, + "Num Negative": 12981, + "Num Positive": 230, + "Positive %": 1.741, + "Num Positive per mm^2": 129.06 + } +} \ No newline at end of file diff --git a/577/TumorCenter_CD3_block16_x4_y6_patient577_1.json b/577/TumorCenter_CD3_block16_x4_y6_patient577_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9daa40d72b47601b63729c9ef157f972b5433d8d --- /dev/null +++ b/577/TumorCenter_CD3_block16_x4_y6_patient577_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14367.4, + "Centroid Y µm": 15541.8, + "Num Detections": 16407, + "Num Negative": 16165, + "Num Positive": 242, + "Positive %": 1.475, + "Num Positive per mm^2": 101.58 + } +} \ No newline at end of file diff --git a/577/TumorCenter_CD8_block16_x3_y6_patient577_0.json b/577/TumorCenter_CD8_block16_x3_y6_patient577_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b6c2b3b7149da59abeede0fcbcb2626a1f47f414 --- /dev/null +++ b/577/TumorCenter_CD8_block16_x3_y6_patient577_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 15466.8, + "Num Detections": 13563, + "Num Negative": 13510, + "Num Positive": 53, + "Positive %": 0.3908, + "Num Positive per mm^2": 30.96 + } +} \ No newline at end of file diff --git a/577/TumorCenter_CD8_block16_x4_y6_patient577_1.json b/577/TumorCenter_CD8_block16_x4_y6_patient577_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7f1fcaf7bee94da84db153bd947e581a032bb9fb --- /dev/null +++ b/577/TumorCenter_CD8_block16_x4_y6_patient577_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 15416.8, + "Num Detections": 17370, + "Num Negative": 17298, + "Num Positive": 72, + "Positive %": 0.4145, + "Num Positive per mm^2": 30.59 + } +} \ No newline at end of file diff --git a/577/history_text.txt b/577/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b37cd477c33dec751095b0072930970f2b88be49 --- /dev/null +++ b/577/history_text.txt @@ -0,0 +1 @@ +Post pT2 pN2b tongue base carcinoma on the right with laser resection and neck dissection on both sides and subsequent radiochemotherapy up to 63 Gy in 2005. Now histologically confirmed squamous cell carcinoma of the dorsum of the tongue on the right G2 and indication for the above-mentioned operation. \ No newline at end of file diff --git a/577/icd_codes.txt b/577/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d63e6b86e23767a6fc9d1c4221b7bcda1dd12370 --- /dev/null +++ b/577/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der dorsalen Zunge[C02.0 ] \ No newline at end of file diff --git a/577/ops_codes.txt b/577/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f2611d16d47ba8157ce33e2fbe1407e09db314c4 --- /dev/null +++ b/577/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/577/patient_clinical_data.json b/577/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6327e7b5426c48149b23c2904bec65568734dc93 --- /dev/null +++ b/577/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/577/patient_pathological_data.json b/577/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6ad98ebd862f92c25e96ef01b2045b95fe532791 --- /dev/null +++ b/577/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "577", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.95 +} \ No newline at end of file diff --git a/577/surgery_description.txt b/577/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff92b13e4a6b36995b97f1c9981ec49ff00ca9d1 --- /dev/null +++ b/577/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion diff --git a/577/surgery_report.txt b/577/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..92d2f6dc40c5a501f9c5788506020929d85f287c --- /dev/null +++ b/577/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, the tracheoscopy is performed with 0 degree optics. Here the vocal fold level is free of irritation, the trachea up to the carina is inconspicuous. Now enter with the esophagogastroscope under dental protection. The esophageal mucosa and gastric mucosa are unremarkable. No evidence of tumor growth. Now enter under dental protection with the size C small bore tube and inspect the oral vestibule and oral cavity. Here the previously described exophytic tumor of the dorsum of the tongue on the left can be seen, approx. 2.5 x 1.5 cm in size, palpatorily it crosses the midline. The remaining mucosa of the oral cavity and oropharynx is unremarkable. The base of the tongue on the right is scarred without irritation. The piriform sinus can be freely unfolded on both sides, the esophageal entrance is also inconspicuous. No evidence of tumor growth in the hypopharynx and larynx - smooth, irritation-free mucosa on all sides. Now cut around the tumor with the electric needle with a safety distance of approx. 3 mm to the muscle fibers. Cut the muscle fibers of the back of the tongue using bipolar coagulation and the scissors. Suture marking of the tumor anterior long-long and medial short-short. Finally, removal of the tumor under bipolar coagulation. Now take circular marginal samples and a marginal sample of the base of the tongue - these go to the frozen section. After telephone consultation with the pathology department, the margins are R0. Repeated precise hemostasis using bipolar coagulation and readaptation and multiple wound closure using PDS 4 sutures. \ No newline at end of file diff --git a/578/InvasionFront_CD8_block6_x5_y11_patient578_0.json b/578/InvasionFront_CD8_block6_x5_y11_patient578_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5791e57680bc348798dc723d9edaf9f13cf68681 --- /dev/null +++ b/578/InvasionFront_CD8_block6_x5_y11_patient578_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 28285.0, + "Num Detections": 20220, + "Num Negative": 18043, + "Num Positive": 2177, + "Positive %": 10.77, + "Num Positive per mm^2": 866.5 + } +} \ No newline at end of file diff --git a/578/InvasionFront_CD8_block6_x6_y11_patient578_1.json b/578/InvasionFront_CD8_block6_x6_y11_patient578_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3fa0e4e365a2c67b073c592589ae372c8e7cdd62 --- /dev/null +++ b/578/InvasionFront_CD8_block6_x6_y11_patient578_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19314.8, + "Centroid Y µm": 28360.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/578/TumorCenter_CD3_block6_x5_y11_patient578_0.json b/578/TumorCenter_CD3_block6_x5_y11_patient578_0.json new file mode 100644 index 0000000000000000000000000000000000000000..75992cf9856bffd1345485b4f86a8e41e9bc905b --- /dev/null +++ b/578/TumorCenter_CD3_block6_x5_y11_patient578_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 27960.2, + "Num Detections": 30166, + "Num Negative": 24658, + "Num Positive": 5508, + "Positive %": 18.26, + "Num Positive per mm^2": 1921.5 + } +} \ No newline at end of file diff --git a/578/TumorCenter_CD3_block6_x6_y11_patient578_1.json b/578/TumorCenter_CD3_block6_x6_y11_patient578_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3de22d27e1efabe9f9d472c36369a64518aa7837 --- /dev/null +++ b/578/TumorCenter_CD3_block6_x6_y11_patient578_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 27935.2, + "Num Detections": 31104, + "Num Negative": 26308, + "Num Positive": 4796, + "Positive %": 15.42, + "Num Positive per mm^2": 1620.2 + } +} \ No newline at end of file diff --git a/578/TumorCenter_CD8_block6_x5_y11_patient578_0.json b/578/TumorCenter_CD8_block6_x5_y11_patient578_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b5f58f647d66b7a8416b5a7efbf57fda06b1d9b8 --- /dev/null +++ b/578/TumorCenter_CD8_block6_x5_y11_patient578_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 28534.9, + "Num Detections": 35209, + "Num Negative": 33812, + "Num Positive": 1397, + "Positive %": 3.968, + "Num Positive per mm^2": 487.85 + } +} \ No newline at end of file diff --git a/578/TumorCenter_CD8_block6_x6_y11_patient578_1.json b/578/TumorCenter_CD8_block6_x6_y11_patient578_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d63af7e13c729176065df5d8e7f040c73237cc7e --- /dev/null +++ b/578/TumorCenter_CD8_block6_x6_y11_patient578_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 28759.8, + "Num Detections": 37251, + "Num Negative": 36186, + "Num Positive": 1065, + "Positive %": 2.859, + "Num Positive per mm^2": 360.55 + } +} \ No newline at end of file diff --git a/578/history_text.txt b/578/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..024603df50760bce4cf92574c7dfbeb275d06a3c --- /dev/null +++ b/578/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Large, rapidly progressive mass in the area of the right tonsil. CT scan most likely corresponds to a T2 tonsillar carcinoma. \ No newline at end of file diff --git a/578/icd_codes.txt b/578/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2405a3a2a1f520660c5cade89c8e5753d0d51ba7 --- /dev/null +++ b/578/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] \ No newline at end of file diff --git a/578/ops_codes.txt b/578/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..55412a7346ec927cc67f0622557d72b97f076a94 --- /dev/null +++ b/578/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Pharyngoskopie: Indirekt[1-611.1 ] Diagnostische Rhinoskopie[1-612 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Transorale radikale Tonsillektomie [ohne Adenotomie][5-281.2 ] \ No newline at end of file diff --git a/578/patient_clinical_data.json b/578/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7c535fcb63e50e3156d5839bca03b9f227526e22 --- /dev/null +++ b/578/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "proton therapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "Protonentherapie", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/578/patient_pathological_data.json b/578/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..69e05f59bd6da8cfa544e66006bc88ab2472eb23 --- /dev/null +++ b/578/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "578", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/578/surgery_description.txt b/578/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..54bdf9215cd322afdfb11e038342559e10ac4a95 --- /dev/null +++ b/578/surgery_description.txt @@ -0,0 +1 @@ +Panendo, Tumor-Tonsillektomie diff --git a/578/surgery_report.txt b/578/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..22963dbbc64ecf9e9ed5f86a5de01a1f0e4c2e11 --- /dev/null +++ b/578/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. First advance the 0° optic through the glottic plane into the trachea. Inconspicuous mucosal conditions up to the exit of the segmental bronchi. No abnormalities in the area of the cervical trachea on reflection. Now intubation of the patient. Inspection of the glottis, subglottis and supraglottis. Inconspicuous mucosal conditions. No abnormalities in the hypopharynx on both sides or in the postcricoid region. Inspection of the base of the tongue shows inconspicuous mucosal conditions. No abnormalities in the area of the oral cavity and nasopharynx after pulling up the soft palate. Advance the flexible esophagoscope into the stomach. Careful reflection back. Inconspicuous mucosal conditions in the area of the stomach and oesophagus. Adjustment with the tonsil retractor. There is a large mass in the area of the right tonsil, which clearly extends laterally. The left tonsil appears inconspicuous. Incision of the mucosal margin close to the uvula and exposure of the capsule of the tumor, which can be exposed far laterally. Extremely difficult dissection. However, it is possible to remove the tumor completely along the capsule, most likely................. the tonsil. Careful dissection both laterally and in the area of the posterior palatal arch. Separation of the tonsil in the area of the base of the tongue. Formation of a mucosal plasty. Careful hemostasis. Dry conditions at the end of the operation. Completion of the procedure without complications. Final consultation with the anesthetist. Further procedure depending on the histology. Note: In view of the size of the tonsil and the strong contact vulnerability with consecutive bleeding, very difficult preparation conditions. \ No newline at end of file diff --git a/579/InvasionFront_CD3_block19_x3_y5_patient579_0.json b/579/InvasionFront_CD3_block19_x3_y5_patient579_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fedf8723b28ee710d5e628f7ac4d66f7e8471303 --- /dev/null +++ b/579/InvasionFront_CD3_block19_x3_y5_patient579_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12268.5, + "Centroid Y µm": 14942.1, + "Num Detections": 11185, + "Num Negative": 10499, + "Num Positive": 686, + "Positive %": 6.133, + "Num Positive per mm^2": 533.34 + } +} \ No newline at end of file diff --git a/579/InvasionFront_CD3_block19_x4_y5_patient579_1.json b/579/InvasionFront_CD3_block19_x4_y5_patient579_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6927c98d46df4155c2860eddb8340cd6a3044b20 --- /dev/null +++ b/579/InvasionFront_CD3_block19_x4_y5_patient579_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14592.3, + "Centroid Y µm": 15117.0, + "Num Detections": 14061, + "Num Negative": 14013, + "Num Positive": 48, + "Positive %": 0.3414, + "Num Positive per mm^2": 30.84 + } +} \ No newline at end of file diff --git a/579/InvasionFront_CD8_block19_x3_y5_patient579_0.json b/579/InvasionFront_CD8_block19_x3_y5_patient579_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b7cdc4556e16d1eb859cdf82255c8d327955eb4 --- /dev/null +++ b/579/InvasionFront_CD8_block19_x3_y5_patient579_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11768.8, + "Centroid Y µm": 22488.1, + "Num Detections": 16169, + "Num Negative": 14009, + "Num Positive": 2160, + "Positive %": 13.36, + "Num Positive per mm^2": 1072.6 + } +} \ No newline at end of file diff --git a/579/InvasionFront_CD8_block19_x4_y5_patient579_1.json b/579/InvasionFront_CD8_block19_x4_y5_patient579_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ff32b76210e80e1b91d14d27153cfde8d43e19fd --- /dev/null +++ b/579/InvasionFront_CD8_block19_x4_y5_patient579_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 22563.1, + "Num Detections": 15030, + "Num Negative": 13460, + "Num Positive": 1570, + "Positive %": 10.45, + "Num Positive per mm^2": 803.63 + } +} \ No newline at end of file diff --git a/579/TumorCenter_CD3_block19_x3_y5_patient579_0.json b/579/TumorCenter_CD3_block19_x3_y5_patient579_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0a3aa6001e9430788f5f3bd75d2b4df8c531a144 --- /dev/null +++ b/579/TumorCenter_CD3_block19_x3_y5_patient579_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11693.8, + "Centroid Y µm": 13817.7, + "Num Detections": 17875, + "Num Negative": 15532, + "Num Positive": 2343, + "Positive %": 13.11, + "Num Positive per mm^2": 1118.1 + } +} \ No newline at end of file diff --git a/579/TumorCenter_CD3_block19_x4_y5_patient579_1.json b/579/TumorCenter_CD3_block19_x4_y5_patient579_1.json new file mode 100644 index 0000000000000000000000000000000000000000..02b21f916604de3bbf8b1bd4f8a993d0651950b3 --- /dev/null +++ b/579/TumorCenter_CD3_block19_x4_y5_patient579_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 13417.9, + "Num Detections": 15217, + "Num Negative": 14253, + "Num Positive": 964, + "Positive %": 6.335, + "Num Positive per mm^2": 540.34 + } +} \ No newline at end of file diff --git a/579/TumorCenter_CD8_block19_x3_y5_patient579_0.json b/579/TumorCenter_CD8_block19_x3_y5_patient579_0.json new file mode 100644 index 0000000000000000000000000000000000000000..606b2f935a488adee487d99d5efc58eb2c6443ba --- /dev/null +++ b/579/TumorCenter_CD8_block19_x3_y5_patient579_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 23687.5, + "Num Detections": 18319, + "Num Negative": 15925, + "Num Positive": 2394, + "Positive %": 13.07, + "Num Positive per mm^2": 1095.7 + } +} \ No newline at end of file diff --git a/579/TumorCenter_CD8_block19_x4_y5_patient579_1.json b/579/TumorCenter_CD8_block19_x4_y5_patient579_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3428643952b9f966f41ebc7755cad731b29f8e9a --- /dev/null +++ b/579/TumorCenter_CD8_block19_x4_y5_patient579_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 23562.5, + "Num Detections": 16483, + "Num Negative": 15294, + "Num Positive": 1189, + "Positive %": 7.213, + "Num Positive per mm^2": 615.73 + } +} \ No newline at end of file diff --git a/579/history_text.txt b/579/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0ca36291dd9e5ad9102975f783831ddb5af8647e --- /dev/null +++ b/579/history_text.txt @@ -0,0 +1 @@ +The patient is suffering from oral floor carcinoma, which was operated on externally in 2002 and followed up with adjuvant therapy. There is a condition after radiotherapy up to 59.4 Gy including the neck regions. There is currently a mass in the area of the supraglottis on the left side with thyroid cartilage perforation. \ No newline at end of file diff --git a/579/icd_codes.txt b/579/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8eb6cd7fac5c3b99c69823658dd38a1c2ee7589f --- /dev/null +++ b/579/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 L] \ No newline at end of file diff --git a/579/ops_codes.txt b/579/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..90e65f9ca163435e4ad88ed9d48c7fa84fdcb83b --- /dev/null +++ b/579/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 2 Regionen[5-403.01 B] Permanente Tracheotomie[5-312.0 ] Ösophagomyotomie pharyngozervikal offen chirurgisch thorakal[5-420.11 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/579/patient_clinical_data.json b/579/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..86afda059ee9ddc0a5065ef374753bc5d5ab5dc1 --- /dev/null +++ b/579/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/579/patient_pathological_data.json b/579/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bd2b70635d0401237d6be6fc293fa107b1f9017a --- /dev/null +++ b/579/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "579", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/579/surgery_description.txt b/579/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..78d75fe9c310cc7e5846a1ad52b0241ba2f34334 --- /dev/null +++ b/579/surgery_description.txt @@ -0,0 +1 @@ +Laryngektomie, Tracheotomie, PEG-Anlage diff --git a/579/surgery_report.txt b/579/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..715ada22c1aa8fc85b3ff368b7b028a4665aa3f1 --- /dev/null +++ b/579/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and bronchoscopic intubation by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the hypopharynx and larynx. An exophytic mass was found in the arytenoid region, which spread to the aryepiglottic fold and anteriorly to the pouch fold and vocal folds. CT morphological suspicion of thyroid cartilage and soft tissue infiltration on the left side. Using a flexible gastroesophagoscope, the patient is examined and the scope is advanced into the stomach. Inconspicuous mucosal conditions here. The PEG is inserted using the thread pull-through method. A good diaphanoscopy can be seen. Now position the patient. Injection, sterile washing and draping. Applying an apron flap in the usual manner. Exposure of the sternocleidomastoid muscle on both sides. Exposure of the cervical vascular sheath on both sides. Neck dissection is largely dispensed with in the case of cN0 neck status. Release of the hyoid bone. This is done without any problems. Detachment of the thyroid gland on both sides. Detachment of the oblique laryngeal muscles on the right side, on the left side this must be done carefully due to suspected soft tissue infiltration. Now detach the neck preparation in level VI on the right side, on the left side the neck preparation is integrated into the laryngeal preparation. Cut through the artery, vein and superior laryngeal nerve on both sides. Enter the pharynx on the right side. Then disluxation of the epiglottis and incision of the mucosa, incision behind the arytenoid region, then removal of the larynx below the cricoid cartilage. A tracheotomy was performed beforehand between the first and second tracheal cartilages. The larynx as a whole goes to the frozen section. No invasive carcinoma and no carcinoma in situ in the frozen section. Only suspected moderate dysplasia on the right side, which was not covered by the tumor. Intraoperative demonstration of the defect on . A joint decision is made not to perform a transplant as the defect is relatively small. Therefore, in the usual manner, the pharynx is sutured in two layers, then a third layer is sutured over it as well as possible using muscle. A left-lateral, dorsal myotomy of the esophageal opening was performed beforehand and the insertions of the sternocleidomastoid muscle were reduced. The apron flap was folded back. Incision of the tracheostoma. Insertion of two Redon drains. Two-layer wound closure. Application of a wrap bandage. Please continue antibiotics for at least 24 hours. Nutrition via the inserted PEG tube. The dressing must be changed daily and should be left in place for a total of one week. X-ray vomiting only on the 14th postoperative day due to the salvage situation. \ No newline at end of file diff --git a/580/InvasionFront_CD3_block20_x5_y3_patient580_0.json b/580/InvasionFront_CD3_block20_x5_y3_patient580_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8ca6db2b6edd8d7558952faf817d70eed94fa9be --- /dev/null +++ b/580/InvasionFront_CD3_block20_x5_y3_patient580_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17840.6, + "Centroid Y µm": 7820.9, + "Num Detections": 12428, + "Num Negative": 12301, + "Num Positive": 127, + "Positive %": 1.022, + "Num Positive per mm^2": 106.74 + } +} \ No newline at end of file diff --git a/580/InvasionFront_CD3_block20_x6_y3_patient580_1.json b/580/InvasionFront_CD3_block20_x6_y3_patient580_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0f65b75cef61da06453501aa91bc3c8d25f62604 --- /dev/null +++ b/580/InvasionFront_CD3_block20_x6_y3_patient580_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20389.2, + "Centroid Y µm": 8120.7, + "Num Detections": 16534, + "Num Negative": 16403, + "Num Positive": 131, + "Positive %": 0.7923, + "Num Positive per mm^2": 76.85 + } +} \ No newline at end of file diff --git a/580/InvasionFront_CD8_block20_x5_y3_patient580_0.json b/580/InvasionFront_CD8_block20_x5_y3_patient580_0.json new file mode 100644 index 0000000000000000000000000000000000000000..481465311730f2dc5667bf6de5c7974ae3e72664 --- /dev/null +++ b/580/InvasionFront_CD8_block20_x5_y3_patient580_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 7421.1, + "Num Detections": 19095, + "Num Negative": 18769, + "Num Positive": 326, + "Positive %": 1.707, + "Num Positive per mm^2": 167.99 + } +} \ No newline at end of file diff --git a/580/InvasionFront_CD8_block20_x6_y3_patient580_1.json b/580/InvasionFront_CD8_block20_x6_y3_patient580_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7de0bf15cfc3e97833d37cf92561076864c6d59 --- /dev/null +++ b/580/InvasionFront_CD8_block20_x6_y3_patient580_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 7346.1, + "Num Detections": 18014, + "Num Negative": 17900, + "Num Positive": 114, + "Positive %": 0.6328, + "Num Positive per mm^2": 55.67 + } +} \ No newline at end of file diff --git a/580/TumorCenter_CD3_block20_x5_y3_patient580_0.json b/580/TumorCenter_CD3_block20_x5_y3_patient580_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7aaa668719d2af2ef6ae68066993399c8519bec3 --- /dev/null +++ b/580/TumorCenter_CD3_block20_x5_y3_patient580_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16387.8, + "Centroid Y µm": 6929.9, + "Num Detections": 16964, + "Num Negative": 16813, + "Num Positive": 151, + "Positive %": 0.8901, + "Num Positive per mm^2": 79.25 + } +} \ No newline at end of file diff --git a/580/TumorCenter_CD3_block20_x6_y3_patient580_1.json b/580/TumorCenter_CD3_block20_x6_y3_patient580_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dac74bd6a0eae11a774936891dfe30e289f256df --- /dev/null +++ b/580/TumorCenter_CD3_block20_x6_y3_patient580_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18939.3, + "Centroid Y µm": 6898.7, + "Num Detections": 17174, + "Num Negative": 17099, + "Num Positive": 75, + "Positive %": 0.4367, + "Num Positive per mm^2": 39.6 + } +} \ No newline at end of file diff --git a/580/TumorCenter_CD8_block20_x5_y3_patient580_0.json b/580/TumorCenter_CD8_block20_x5_y3_patient580_0.json new file mode 100644 index 0000000000000000000000000000000000000000..54f1474b4e8ef554bd6b87166868f29afaae0cca --- /dev/null +++ b/580/TumorCenter_CD8_block20_x5_y3_patient580_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15391.9, + "Centroid Y µm": 7171.2, + "Num Detections": 19165, + "Num Negative": 19143, + "Num Positive": 22, + "Positive %": 0.1148, + "Num Positive per mm^2": 11.33 + } +} \ No newline at end of file diff --git a/580/TumorCenter_CD8_block20_x6_y3_patient580_1.json b/580/TumorCenter_CD8_block20_x6_y3_patient580_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9270e4d1134770986ba39290913be0c4364ccdf0 --- /dev/null +++ b/580/TumorCenter_CD8_block20_x6_y3_patient580_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17765.6, + "Centroid Y µm": 6971.3, + "Num Detections": 18583, + "Num Negative": 18577, + "Num Positive": 6, + "Positive %": 0.0323, + "Num Positive per mm^2": 3.129 + } +} \ No newline at end of file diff --git a/580/history_text.txt b/580/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/580/icd_codes.txt b/580/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/580/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/580/ops_codes.txt b/580/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b3e1d9a6487ae6155875c608494dbdb877f2fe53 --- /dev/null +++ b/580/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Hemithyreoidektomie und subtotale Resektion Gegenseite[5-062.5 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Permanente Tracheotomie[5-312.0 ] Einlegen einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/580/patient_clinical_data.json b/580/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a45f549210d991a646fe5fd567d49a00a567cbfe --- /dev/null +++ b/580/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 6, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/580/patient_pathological_data.json b/580/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7d5c1ae5c8f69f4e8f686660f8a42741d33a9c70 --- /dev/null +++ b/580/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "580", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 27.0 +} \ No newline at end of file diff --git a/580/surgery_description.txt b/580/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..56107d7061f1137361705f6b308e009b35785119 --- /dev/null +++ b/580/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck dissection, Laryngektomie, perm. Tracheotomie, Hemithyroidektomie rechts diff --git a/580/surgery_report.txt b/580/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b294e1753cbe4308f925499fa9b969bbc50c4f92 --- /dev/null +++ b/580/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and transnasal intubation by the anesthesia colleagues. Entry with the small bore tube and inspection of the hypopharynx and larynx. There is an exophytic mass in the laryngeal region, which starts from the right glottic plane, infiltrates the pocket folds and the anterior commissure, extends to the opposite side and involves the entire postcricoid region on the right side. Further extended subglottic extension to approx. 2.5 cm below the glottic plane. Sinus piriformes and esophageal entrance as well as epiglottis free on both sides. Injection of xylocaine-adrenaline mixture and sterile washing and draping. Creation of an apron flap and start with the release of the larynx on the left side. Exposure of the sternocleidomastoid muscle, the cervical vascular sheath and the omohyoid muscle as well as the hyoid bone. The 4-cervical vascular sheath is detached from the larynx. The superior laryngeal nerve, artery and superior laryngeal vein are cut off. Then release the hyoid bone and release the piriform sinus, exposing the thyroid cartilage and removing the infrahyoid muscles on the left side. Then transition to the right side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the cervical vascular sheath. Detachment of the cervical vascular sheath from the larynx. Detachment of the thyroid gland. Here it can be seen that the thyroid gland on the right side is nodularly altered and very coarse; the thyroid isthmus is also very coarse in the middle, in the sense of a nodule, altered in a manner suspicious of metastases. The thyroid gland is dissected close to the capsule so that the epithelial bodies fall dorsally. Intraoperative demonstration on . He confirms that the epithelial bodies on the right side were not removed. Then release of the piriform sinus with visualization of the thyroid cartilage and the posterior surface of the thyroid cartilage. This is only partially successful. Then release of the hyoid bone and removal of the hyoid bone. Then enter the pharynx at the level of the epiglottis. Pull out the epiglottis. Cut along the posterior edge of the epiglottis up to the postcricoid region. Then release the postcricoid region while saving the mucosa. Release of the esophagus from the trachea. Prior to this, a deep tracheotomy was performed between the 3rd and 4th tracheal cartilage. The laryngeal preparation is then also removed at this level. A marginal sample is taken from the laryngeal preparation in the area of the trachea and sent for frozen section. There is no evidence of invasive carcinoma, carcinoma in situ or dysplasia. The laryngeal specimen itself is sent for final histology. Then insertion of a size 8 Provox prosthesis in the usual manner. Perform the pharyngeal suture in the usual manner, initially in two layers and after completion of the neck dissection by adapting the prelaryngeal muscles and the pharyngeal muscles. Then neck dissection on the right side. Exposure of the submandibular gland, the accessorius nerve, the hypoglossal nerve, the cervical sinus and free preparation of the internal jugular vein. Release of the neck preparation II a to V a, sparing the plexus branches. Then neck dissection on the left side. Exposure of the submandibular gland, the accessorius nerve and the ................................ nerve. Then release the neck preparation II a to V a, while protecting the plexus branches. Then perform the myotomy at the insertion of the sternocleidomastoid muscle on both sides. Insertion of 2 Redon drainage tubes and insertion of the tracheostoma. This is relatively difficult as the tracheostoma is very deep. Two-layer wound closure and completion of the operation without complications. Post-operative calcium control according to standard thyroid regimen. X-ray gruel swallow on the 10th postoperative day. Antibiotics for 24 hours. \ No newline at end of file diff --git a/581/InvasionFront_CD3_block4_x5_y1_patient581_0.json b/581/InvasionFront_CD3_block4_x5_y1_patient581_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79728f8af09b60b5fd62092bee6ea1e798c44abe --- /dev/null +++ b/581/InvasionFront_CD3_block4_x5_y1_patient581_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19314.8, + "Centroid Y µm": 9020.2, + "Num Detections": 19792, + "Num Negative": 13401, + "Num Positive": 6391, + "Positive %": 32.29, + "Num Positive per mm^2": 3067.4 + } +} \ No newline at end of file diff --git a/581/InvasionFront_CD3_block4_x6_y1_patient581_1.json b/581/InvasionFront_CD3_block4_x6_y1_patient581_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bbbd622c2ee1ebd014d9e4bae962c4b569b4f1a4 --- /dev/null +++ b/581/InvasionFront_CD3_block4_x6_y1_patient581_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22088.3, + "Centroid Y µm": 9095.2, + "Num Detections": 15852, + "Num Negative": 11554, + "Num Positive": 4298, + "Positive %": 27.11, + "Num Positive per mm^2": 2607.0 + } +} \ No newline at end of file diff --git a/581/InvasionFront_CD8_block4_x5_y1_patient581_0.json b/581/InvasionFront_CD8_block4_x5_y1_patient581_0.json new file mode 100644 index 0000000000000000000000000000000000000000..165b287d4a7ffd1c3d8b4ac2c6ae11fc67419310 --- /dev/null +++ b/581/InvasionFront_CD8_block4_x5_y1_patient581_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 7596.0, + "Num Detections": 21842, + "Num Negative": 18265, + "Num Positive": 3577, + "Positive %": 16.38, + "Num Positive per mm^2": 1668.2 + } +} \ No newline at end of file diff --git a/581/InvasionFront_CD8_block4_x6_y1_patient581_1.json b/581/InvasionFront_CD8_block4_x6_y1_patient581_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43210cfdf1f575c37a596c1b7f86d01b2d9877f0 --- /dev/null +++ b/581/InvasionFront_CD8_block4_x6_y1_patient581_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 7396.1, + "Num Detections": 15653, + "Num Negative": 13478, + "Num Positive": 2175, + "Positive %": 13.9, + "Num Positive per mm^2": 1424.4 + } +} \ No newline at end of file diff --git a/581/TumorCenter_CD3_block4_x5_y1_patient581_0.json b/581/TumorCenter_CD3_block4_x5_y1_patient581_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7dafb8cae2d97369b71151c770e6afe5639110ec --- /dev/null +++ b/581/TumorCenter_CD3_block4_x5_y1_patient581_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 2623.6, + "Num Detections": 23755, + "Num Negative": 12280, + "Num Positive": 11475, + "Positive %": 48.31, + "Num Positive per mm^2": 4439.2 + } +} \ No newline at end of file diff --git a/581/TumorCenter_CD3_block4_x6_y1_patient581_1.json b/581/TumorCenter_CD3_block4_x6_y1_patient581_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dbf26119aafc0406223077b66f9128435d091020 --- /dev/null +++ b/581/TumorCenter_CD3_block4_x6_y1_patient581_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 2623.6, + "Num Detections": 19083, + "Num Negative": 9826, + "Num Positive": 9257, + "Positive %": 48.51, + "Num Positive per mm^2": 4253.3 + } +} \ No newline at end of file diff --git a/581/TumorCenter_CD8_block4_x5_y1_patient581_0.json b/581/TumorCenter_CD8_block4_x5_y1_patient581_0.json new file mode 100644 index 0000000000000000000000000000000000000000..abc5ae0e9807a012936fb71eba74a21cb81acf71 --- /dev/null +++ b/581/TumorCenter_CD8_block4_x5_y1_patient581_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17515.7, + "Centroid Y µm": 2723.6, + "Num Detections": 26238, + "Num Negative": 19992, + "Num Positive": 6246, + "Positive %": 23.81, + "Num Positive per mm^2": 2519.9 + } +} \ No newline at end of file diff --git a/581/TumorCenter_CD8_block4_x6_y1_patient581_1.json b/581/TumorCenter_CD8_block4_x6_y1_patient581_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e540deed2b5e0144ce903869bc04d742a23c1989 --- /dev/null +++ b/581/TumorCenter_CD8_block4_x6_y1_patient581_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19789.5, + "Centroid Y µm": 2823.5, + "Num Detections": 20190, + "Num Negative": 15548, + "Num Positive": 4642, + "Positive %": 22.99, + "Num Positive per mm^2": 2294.0 + } +} \ No newline at end of file diff --git a/581/history_text.txt b/581/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/581/icd_codes.txt b/581/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0fad41f23ab301e82c30dc944252dbe29f2a18de --- /dev/null +++ b/581/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/581/ops_codes.txt b/581/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1c7155c9df1703cfaf3d422b9d273830865f95a6 --- /dev/null +++ b/581/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/581/patient_clinical_data.json b/581/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..355d8be6048ddbccfac361e96028290ba946aef5 --- /dev/null +++ b/581/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/581/patient_pathological_data.json b/581/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4a16144e7f5f2371878781a90b4af44c2ec38b8e --- /dev/null +++ b/581/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "581", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/581/surgery_description.txt b/581/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..42c40b09f444ff77e946282918c12941ff6e293a --- /dev/null +++ b/581/surgery_description.txt @@ -0,0 +1 @@ +Tonsillektomie, Neck dissection sowie PEG-Anlage diff --git a/581/surgery_report.txt b/581/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..053fb5d781d8effc6428ff7196123d94cd71bbd6 --- /dev/null +++ b/581/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Positioning of the patient and insertion of the mouth guard. An exophytic tumor can be seen, which particularly involves the tonsil on the left side in the area of the middle and lower half of the tonsil and extends to the base of the tongue. The resection begins parauvularly in the area of the anterior and posterior palatal arch. Here resection with the electric needle. Care is taken to ensure a sufficient safety distance of more than 5 mm. The resection is carried out from the cranial to the lateral, into the pharyngeal muscles. Further resection is carried out strictly along the pharyngeal musculature, which in some cases only forms a wafer-thin bridge into the parapharyngeal space. Several larger vascular inflows are partially coagulated here, but also partially cut off. The resection continues towards the caudal tonsil pole. Further dissection along the pharyngeal musculature. It can now be seen that the tumor clearly extends to the base of the tongue. Therefore, the tumor is finally resected macroscopically in toto with a large portion of the base of the tongue. Careful hemostasis. The specimen is thread-marked for histopathological evaluation. In the meantime, a radical neck dissection of the left side of the neck is performed. This was possible due to the continuous musculature of the pharynx, which, although only partially very thin, could be preserved in continuity. The intraoperative frozen section revealed that although the margin of the base of the tongue was R0, it appeared to be very narrow. Therefore, after performing the neck dissection, an additional resection was performed in the area of the base of the tongue. This was performed without any problems. Subtle hemostasis was performed again so that the wound was sufficiently dry at the end of the operation. Neck dissection on the left. Skin incision curved in the typical manner, just below the tip of the mastoid to the level of the omohyoid muscle. Dissection of subcutaneous tissue and platysma. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and exposure of the digastric muscle. A large tumor conglomerate is visible, which is fixed to the sternocleidomastoid muscle and can be mobilized by partially removing the muscle. First visualization of the facial vein, which is ligated. Exposure of the internal jugular vein. The tumor node can be dissected from the jugular vein below it. Exposure of the internal and external carotid arteries and the superior thyroid artery. Exposure, displacement, neurolysis and re-embedding of the following nerves: vagus nerve, hypoglossal nerve, cervical nerve. The accessorius nerve in particular is firmly fused to the tumor conglomerate and can be detached with difficulty, but preserved. All branches of the cervical plexus are also exposed and preserved. The capsule of the submandibular gland was removed caudally. The overall result is an evacuation of levels II to V. Apart from the clear malignancy of the lymph node conglomerate, there are still some lymph nodes in the specimen that appear to be suspicious. Finally, careful irrigation and hemostasis. Wound closure in layers with insertion of a Redon drainage. Application of a pressure dressing. After a positive diaphanoscopy, the PEG is placed using the thread pull-through method. Dressing application. Final consultation with the anesthetist. \ No newline at end of file diff --git a/582/InvasionFront_CD8_block3_x3_y11_patient582_0.json b/582/InvasionFront_CD8_block3_x3_y11_patient582_0.json new file mode 100644 index 0000000000000000000000000000000000000000..df1f02630a0ab6cabab86b61d9c5be78d642c2da --- /dev/null +++ b/582/InvasionFront_CD8_block3_x3_y11_patient582_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12343.5, + "Centroid Y µm": 27035.7, + "Num Detections": 23506, + "Num Negative": 23115, + "Num Positive": 391, + "Positive %": 1.663, + "Num Positive per mm^2": 157.78 + } +} \ No newline at end of file diff --git a/582/InvasionFront_CD8_block3_x4_y11_patient582_1.json b/582/InvasionFront_CD8_block3_x4_y11_patient582_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dc91bd2561d1e7e2381ae2af7acceaa1ceb4c5e5 --- /dev/null +++ b/582/InvasionFront_CD8_block3_x4_y11_patient582_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14804.7, + "Centroid Y µm": 27123.1, + "Num Detections": 19211, + "Num Negative": 18696, + "Num Positive": 515, + "Positive %": 2.681, + "Num Positive per mm^2": 232.51 + } +} \ No newline at end of file diff --git a/582/TumorCenter_CD3_block3_x3_y11_patient582_0.json b/582/TumorCenter_CD3_block3_x3_y11_patient582_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f7f59a5b5b7bad86e7bad2559b419ac9c1c5c34 --- /dev/null +++ b/582/TumorCenter_CD3_block3_x3_y11_patient582_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 33882.1, + "Num Detections": 3670, + "Num Negative": 2907, + "Num Positive": 763, + "Positive %": 20.79, + "Num Positive per mm^2": 1732.0 + } +} \ No newline at end of file diff --git a/582/TumorCenter_CD3_block3_x4_y11_patient582_1.json b/582/TumorCenter_CD3_block3_x4_y11_patient582_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7f45278249e60a9c553358107054fb734c49ca90 --- /dev/null +++ b/582/TumorCenter_CD3_block3_x4_y11_patient582_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13108.7, + "Centroid Y µm": 33854.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/582/TumorCenter_CD8_block3_x3_y11_patient582_0.json b/582/TumorCenter_CD8_block3_x3_y11_patient582_0.json new file mode 100644 index 0000000000000000000000000000000000000000..54232d8a444c6b7e1b3ba64485109aeefb4d2a05 --- /dev/null +++ b/582/TumorCenter_CD8_block3_x3_y11_patient582_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11060.6, + "Centroid Y µm": 28801.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/582/TumorCenter_CD8_block3_x4_y11_patient582_1.json b/582/TumorCenter_CD8_block3_x4_y11_patient582_1.json new file mode 100644 index 0000000000000000000000000000000000000000..19a1256568af2700a98a7d8ba8b957a2f4a1c023 --- /dev/null +++ b/582/TumorCenter_CD8_block3_x4_y11_patient582_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13193.0, + "Centroid Y µm": 28609.9, + "Num Detections": 13967, + "Num Negative": 13562, + "Num Positive": 405, + "Positive %": 2.9, + "Num Positive per mm^2": 227.59 + } +} \ No newline at end of file diff --git a/582/history_text.txt b/582/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c91c99965747fd99e6b822376654b15d45cd3438 --- /dev/null +++ b/582/history_text.txt @@ -0,0 +1 @@ +The patient had a histologically confirmed, initially clinical cT2 cN2c tonsillar carcinoma on the left. After intubation with the anesthesia colleagues, the Kleinsasser tube was inserted after an unremarkable tracheoscopy and inspection of the findings. There was a relatively small finding of the left palatine tonsil, consistent with a cT2 extension; the lateral left base of the tongue also appeared to be infiltrated. Demonstration of the findings to and planning of the procedure. \ No newline at end of file diff --git a/582/icd_codes.txt b/582/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..730ae13b70566a33503d2a05c0b86caec10045b4 --- /dev/null +++ b/582/icd_codes.txt @@ -0,0 +1 @@ +Sekundäre und nicht näher bezeichnete bösartige Neubildung: Lymphknoten des Kopfes, des Gesichtes und des Halses[C77.0 ] Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] \ No newline at end of file diff --git a/582/ops_codes.txt b/582/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8a2effc8039aed0412a6181f649e6c66970a2a35 --- /dev/null +++ b/582/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion von erkranktem Gewebe des Pharynx: Exzision, lokal[5-292.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 R] Permanente Tracheostomie: Tracheotomie[5-312.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] \ No newline at end of file diff --git a/582/patient_clinical_data.json b/582/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d51e270ced5b8db869a04839b2c55a9b6b6ff226 --- /dev/null +++ b/582/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 46, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/582/patient_pathological_data.json b/582/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b0fc4245a7a3b11ce152bdd6d5151dbb1867ff8e --- /dev/null +++ b/582/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "582", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/582/surgery_description.txt b/582/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..070ca486036b23a24397ba3f08158abc4ce6e719 --- /dev/null +++ b/582/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, Neck Diss. rechts, Tracheotomie diff --git a/582/surgery_report.txt b/582/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cd1c4d622c709491b7e3fbf59b338a07a987bf35 --- /dev/null +++ b/582/surgery_report.txt @@ -0,0 +1 @@ +Now insertion of the tonsil blocker and then start with the tumor resection. The tonsil carcinoma is cut around cranially in the healthy tissue with the electric needle and separated laterally up to the alveolar ridge. The tumor specimen is now developed and removed from the cranial to the caudal side in a plane that is easy to move in the area of the musculature. The lateral base of the tongue is also resected caudally. In between, bipolar hemostasis and removal of the tumor specimen en bloc. In between, the findings were demonstrated intraoperatively on . The tumor is thread-marked for frozen section. During the operation, it was found that the tumor was still interspersed with carcinoma in situ or severe dysplasia caudally in the area of the base of the tongue and in the area of the anterior palatal arch and the glossotonsillar groove. The decision was therefore made to perform a resection. A large piece of mucosa is resected in the area of the glossotonsillar groove in the anterior palatal arch. This is cut to such an extent that part of the submandibular gland is exposed enorally. A large section of the base of the tongue is resected caudally so that the epiglottis is completely visible on the left side. Now a flat piece from the tonsillar loge is resected in toto again to counter the dysplasia described above in the area of the upper anterior palatal arch and transitioning to the posterior pharyngeal wall. These specimens are also sent to the frozen section marked with a thread. Bipolar blood is then stopped. This frozen section is then only found to be interspersed with dysplasia in the area of the base of the tongue. After consultation with , a further section is cut here, which is sent for final histological assessment. Bipolar blood is now meticulously stopped and hydrogen swabs are inserted. Transfer for neck dissection on the right: instillation of 10 ml xylocaine with adrenaline in the area of the sternocleidomastoid margin. Skin incision, cutting of the subcutaneous tissue and the platysma. Ligation of the external jugular vein and removal. Expose the anterior border of the sternocleidomastoid, the accessorius nerve, the cervical vascular nerve sheath and the omohyoid muscle. The cervical vascular nerve sheath is now exposed in the sense of the internal jugular vein, common carotid artery and vagus nerve. The posterior neck preparation is then successively removed from the upper accessorius triangle and completely removed while sparing the plexus branches and the accessorius nerve. Nodes suspicious of metastases are noted in level IIb. The anterior neck dissection is then completed by removal of the capsule of the submandibular gland, visualization of the hypoglossal nerve and three operations in the anterior triangle of the neck. Minor bleeding is coagulated. This is followed by hydrogen and ring irrigation, hemostasis and insertion of a Redon drain. The wound is then closed in two layers if the wound is dry. Now repositioning for tracheotomy: modified Kocher collar incision, cutting of the subcutaneous tissue and displacement of the prelaryngeal veins. Now expose the thyroid isthmus and undermine it. Ligature and weaning. Creation of a Björk flap and insertion of the tracheostoma in the usual manner without complications. An 8-bore tracheostoma is inserted. The patient receives 250 mg SDH and 5 mega penicillin i.v. and is admitted to the intensive care unit for monitoring. Finally, a nasogastric feeding tube was inserted. Conclusion: cT3 cN2c tonsillar carcinoma on the left. Neck dissection on the left side should be performed in about 14 days with an extensive enoral wound cavity. \ No newline at end of file diff --git a/583/InvasionFront_CD3_block1_x1_y5_patient583_0.json b/583/InvasionFront_CD3_block1_x1_y5_patient583_0.json new file mode 100644 index 0000000000000000000000000000000000000000..31c85bb1cc962bf708df1218c77e8be8f87381ae --- /dev/null +++ b/583/InvasionFront_CD3_block1_x1_y5_patient583_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 13992.6, + "Num Detections": 16060, + "Num Negative": 15594, + "Num Positive": 466, + "Positive %": 2.902, + "Num Positive per mm^2": 205.82 + } +} \ No newline at end of file diff --git a/583/InvasionFront_CD3_block1_x2_y5_patient583_1.json b/583/InvasionFront_CD3_block1_x2_y5_patient583_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd91773062a7bd3a32a9fde628fb270080737243 --- /dev/null +++ b/583/InvasionFront_CD3_block1_x2_y5_patient583_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6796.4, + "Centroid Y µm": 14042.6, + "Num Detections": 19247, + "Num Negative": 18887, + "Num Positive": 360, + "Positive %": 1.87, + "Num Positive per mm^2": 144.92 + } +} \ No newline at end of file diff --git a/583/InvasionFront_CD8_block1_x1_y5_patient583_0.json b/583/InvasionFront_CD8_block1_x1_y5_patient583_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ec9db1955929888bd21462be785c0a9d113d4b37 --- /dev/null +++ b/583/InvasionFront_CD8_block1_x1_y5_patient583_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 12443.4, + "Num Detections": 14233, + "Num Negative": 13867, + "Num Positive": 366, + "Positive %": 2.571, + "Num Positive per mm^2": 161.36 + } +} \ No newline at end of file diff --git a/583/InvasionFront_CD8_block1_x2_y5_patient583_1.json b/583/InvasionFront_CD8_block1_x2_y5_patient583_1.json new file mode 100644 index 0000000000000000000000000000000000000000..177fcecf8f7dd0d7874c46e1b9d7c59a38c365d5 --- /dev/null +++ b/583/InvasionFront_CD8_block1_x2_y5_patient583_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 12518.4, + "Num Detections": 19079, + "Num Negative": 18888, + "Num Positive": 191, + "Positive %": 1.001, + "Num Positive per mm^2": 77.3 + } +} \ No newline at end of file diff --git a/583/TumorCenter_CD3_block1_x1_y7_patient583_0.json b/583/TumorCenter_CD3_block1_x1_y7_patient583_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ccdd8f8e0dbda6b773fb438c923506462ede2feb --- /dev/null +++ b/583/TumorCenter_CD3_block1_x1_y7_patient583_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 17740.6, + "Num Detections": 19844, + "Num Negative": 15642, + "Num Positive": 4202, + "Positive %": 21.18, + "Num Positive per mm^2": 1798.1 + } +} \ No newline at end of file diff --git a/583/TumorCenter_CD3_block1_x2_y7_patient583_1.json b/583/TumorCenter_CD3_block1_x2_y7_patient583_1.json new file mode 100644 index 0000000000000000000000000000000000000000..20fd52ba68295b7f0970f3b8c064297398485532 --- /dev/null +++ b/583/TumorCenter_CD3_block1_x2_y7_patient583_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6246.7, + "Centroid Y µm": 17715.6, + "Num Detections": 20264, + "Num Negative": 16676, + "Num Positive": 3588, + "Positive %": 17.71, + "Num Positive per mm^2": 1522.4 + } +} \ No newline at end of file diff --git a/583/TumorCenter_CD8_block1_x1_y5_patient583_0.json b/583/TumorCenter_CD8_block1_x1_y5_patient583_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c9e1d0962b02a76ddb6ed3ecb3f8b1779542981a --- /dev/null +++ b/583/TumorCenter_CD8_block1_x1_y5_patient583_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 21313.7, + "Num Detections": 18394, + "Num Negative": 15239, + "Num Positive": 3155, + "Positive %": 17.15, + "Num Positive per mm^2": 1390.7 + } +} \ No newline at end of file diff --git a/583/TumorCenter_CD8_block1_x2_y5_patient583_1.json b/583/TumorCenter_CD8_block1_x2_y5_patient583_1.json new file mode 100644 index 0000000000000000000000000000000000000000..984b0fc0b80ba3926327dc4828071e66239adc29 --- /dev/null +++ b/583/TumorCenter_CD8_block1_x2_y5_patient583_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8945.3, + "Centroid Y µm": 21263.7, + "Num Detections": 16885, + "Num Negative": 14541, + "Num Positive": 2344, + "Positive %": 13.88, + "Num Positive per mm^2": 1130.2 + } +} \ No newline at end of file diff --git a/583/history_text.txt b/583/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..28c8e7aa2de0202e503266b474f979e3006ab168 --- /dev/null +++ b/583/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oral cavity and oropharyngeal carcinoma on the left. On CT, the tumor extends from the entrance to the nasopharynx to the hypopharyngeal junction. Laterally, per-continuitatem growth, at least in the sonography mandibular infiltration not described. Preoperative vascular evaluation shows infiltration of the externa in the upper area. In the lower area 2 to 3 free outlets. \ No newline at end of file diff --git a/583/icd_codes.txt b/583/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/583/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/583/ops_codes.txt b/583/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b74464e9d18e57bbbcb0b1d831af009f5fbe2ab2 --- /dev/null +++ b/583/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische indirekte Orohypopharyngoskopie[1-611.1 ] Permanente Tracheostomaanlage[5-312.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Entnahme eines myokutanen Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-858.28 R] Transplantat[5-295.04 ] \ No newline at end of file diff --git a/583/patient_clinical_data.json b/583/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1ad516a0c4cb36f36c87b24fa1005a17b5b5ee84 --- /dev/null +++ b/583/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/583/patient_pathological_data.json b/583/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3ccb6d9f8df32d5a23acee2379467ef49ca2d428 --- /dev/null +++ b/583/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "583", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 55, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/583/surgery_description.txt b/583/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2ff4b4bb5d4802568e382da613a15553e5a403c0 --- /dev/null +++ b/583/surgery_description.txt @@ -0,0 +1 @@ +Pharynxteilresektion + Neck dissection + Tracheostoma diff --git a/583/surgery_report.txt b/583/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a40a89729bf423621bee2604f873159475bcc9db --- /dev/null +++ b/583/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy: The described tumor is seen, which occupies almost the entire palatal arch and extends caudally into the entire oropharyngeal side wall, growing into the base of the tongue. Hypopharynx: Lateral mucosal findings are clear. Therefore surgery with flap coverage confirmed. First injection of a total of 20 ml xylocaine 1% with adrenaline in the area of both sides of the throat. Then sterile draping. Start with tracheostoma creation: A small Kocher collar incision is made. Subsequent division of the infrahyoid muscles. Exposure of the thyroid isthmus. This is passed underneath, clamped off and then supplied with a puncture ligature. Exposure of the trachea. Entering the 2nd/3rd intercartilaginous space. Creation of a broad-based modified Björk flap. This is epithelialized. Insertion of a spiral tube. Subsequently combined transoral, transcervical tumor surgery and extended radical neck dissection on the left: First insertion of the McIvor mouth spatula and the mouth retractors in alternation and placement of a tongue retaining suture. The tumor is cut around on all sides with a safety margin of at least 1.5 cm. The entire palatal arch and anterior and posterior wall areas are removed. Resection extends over the alveolar ridge down to the base of the tongue. The floor of the mouth is incised forwards. The posterior half of the tongue body with the base of the tongue is resected close to the raphe. Marginal samples are taken from the entire palatal arch area, including the anterior and posterior wall, from the mucosa above the alveolar ridge, from the floor of the mouth in front, from the body of the tongue and from the base of the tongue. These are all tumor-free in the frozen section and have so far been R0 resected. The neck is then opened with a submandibular curved incision, which is extended caudally. It can be seen that the tumor has infiltrated the sternocleidomastoid muscle and extends cranially towards the base of the skull. There is also evidence of per-continuitatem growth of the tumor laterally to the uppermost lymph node stations. The external carotid artery can be dissected freely and is not infiltrated by the tumor in the lower part. The superior thyroid artery and thyrolingual trunk can still be preserved in the initial area. The facial artery must be sacrificed, as must the external carotid artery, which lies cranial to it. The internal jugular vein is removed caudally and cranially and ligated twice. The external carotid artery is resected in the area of the superficial temporal artery at the border to the entry into the parotid ligament and ligated twice. The internal jugular vein is removed at the entrance to the base of the skull and ligated twice. The hypoglossal nerve is infiltrated by tumor and must also be resected. The internal carotid artery and vagus nerve can be preserved. Accessory nerve is also resected. The sternocleidomastoid muscle is removed cranially. Resection with parts of the cervical plexus and the deep neck muscles if necessary to achieve complete removal in sano. The digastric muscle and submandibular gland are resected en bloc with the tumor in the sense of a pull through. As the operation progresses, it becomes apparent that, in addition to the per-continuitatem situation, there has also been a lateral invasion of the soft tissues of the hyoid bone. The pharyngeal wall is therefore lifted away from the prevertebral fascia. The hyoid bone is resected laterally. The upper part of the superior cornu is also resected. All soft tissues and the mucosa up to the piriform sinus entrance are resected. The posterior wall of the oropharynx and hypopharynx are resected in the necessary portion up to the oropharyngeal entrance up to half. A marginal sample is taken from the posterior wall of the pharynx up to the entrance of the piriform sinus. This is tumor-free, in the cranial area there are still questionable tumor infiltrates in small foci, approx. 1 cm below the tube area, which were partially resected. Another marginal sample was taken and then sent back for a frozen section. This is now tumor-free. A marginal sample is taken from the cranial basal soft tissue. No tumor infiltrates here either. An extensive marginal sample was taken from the caudal area, from the soft tissue at the base of the tongue towards the vallecula and the entrance to the larynx as well as the entrance to the piriform sinus. This is also tumor-free. Surgical resection can therefore now be assumed to be R0. The result is a defect from the tube to the hypopharynx, including the posterior wall of the oropharynx as well as the floor of the mouth, base of the tongue and the entire palate. The mandible was not infiltrated and the periosteum could be easily removed. The edge of the mandible at the angulus is chiseled off with a chisel to achieve a smaller transition and a better overview. All areas of the pterygoid muscle were also resected. The neck dissection on the left side was carried out including level I b and I a. Gland was also resected in the tumor. The lingual nerve and inferior alveolar nerve were also resected. Neck dissection left includes levels I to V. Neck dissection on the right side now follows. This is performed in a typical manner, including levels II to V. The defect is now covered using the anterolateral thigh flap: On the left side, a superior thyroid artery and the truncus thyrolingualis or terminal branch of the external carotid artery are available for vascular connection. The external jugular vein is available for the venous connection. This is followed by Doppler sonography in the anterolateral thigh area. Four perforators can be identified. The flap size was previously measured at 20 x 8 cm. A three-dimensionally configured thigh flap was measured and marked according to the defect. First, medial skin incision. Showing the rectus and vastus lateralis muscles. The ramus descendens can be dissected between these muscles. Then dissect the flap from the lateral side, also subfascially. Caudally dissect the vascular pedicle and ligate it. Successive development of the flap with inclusion of parts of the vastus lateralis muscle corresponding to the course of the perforators. Dissection in the direction of the exit from the profunda femoris artery. The artery and vein are removed here. Arterial and venous stumps are each treated with puncture ligatures. The primary closure is then performed in a typical low-tension manner with the insertion of a Redon drain. The thigh flap is inserted transcervically into the defect and sutured in place with relatively little tension using 3.0 single Vicryl button sutures. The complex defect is covered from the floor of the mouth via the base of the tongue, pharyngeal wall and the entire palatal arch with minimal tension. The flap vessels and the external jugular vein are then conditioned, as is the terminal branch of the external carotid artery, which is selected for flap anastomosis. Vascular suturing is performed with 8.0 ethilon sutures between the external carotid artery, terminal branch and descending ramus. After opening the clamp, good arterial flow and good venous return. Venous anastomosis between the common terminal flap vein and the external jugular vein after measuring with a Coupler measuring device using a 4/0 Coupler. Good venous return, positive smear phenomenon. Now follows layered wound closure on the right cervical side with insertion of a Redon drain. Left cervical with insertion of a flap. Epithelialization of the tracheostoma and insertion of an 8.0 tracheal cannula. Marking of the course of the flap pedicle for postoperative Doppler control. Checking the flap enorally shows a well-perfused flap. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue antibiotics with Unacid for 1 week. Feeding via PEG for at least 10 days, then gruel and, if necessary, diet build-up. Heparin perfusor for 5 days ......... per hour. Regular Doppler checks according to the scheme and enoral flap checks. Overall cT4 cN2c multistage carcinoma, postoperative RCT certainly required. \ No newline at end of file diff --git a/584/InvasionFront_CD3_block12_x3_y5_patient584_0.json b/584/InvasionFront_CD3_block12_x3_y5_patient584_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc7951122895334bc63c9cb944f8e917432de4f8 --- /dev/null +++ b/584/InvasionFront_CD3_block12_x3_y5_patient584_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11668.8, + "Centroid Y µm": 17215.9, + "Num Detections": 20026, + "Num Negative": 19640, + "Num Positive": 386, + "Positive %": 1.927, + "Num Positive per mm^2": 149.06 + } +} \ No newline at end of file diff --git a/584/InvasionFront_CD3_block12_x4_y5_patient584_1.json b/584/InvasionFront_CD3_block12_x4_y5_patient584_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ec5870a87432b15c2bd043be2acf4e98a47d17b5 --- /dev/null +++ b/584/InvasionFront_CD3_block12_x4_y5_patient584_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14167.5, + "Centroid Y µm": 17365.8, + "Num Detections": 21164, + "Num Negative": 20840, + "Num Positive": 324, + "Positive %": 1.531, + "Num Positive per mm^2": 119.7 + } +} \ No newline at end of file diff --git a/584/InvasionFront_CD8_block12_x3_y5_patient584_0.json b/584/InvasionFront_CD8_block12_x3_y5_patient584_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c2d5b61571a2a2c5904e0194995da989533301d1 --- /dev/null +++ b/584/InvasionFront_CD8_block12_x3_y5_patient584_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12018.6, + "Centroid Y µm": 16266.4, + "Num Detections": 22897, + "Num Negative": 22749, + "Num Positive": 148, + "Positive %": 0.6464, + "Num Positive per mm^2": 55.39 + } +} \ No newline at end of file diff --git a/584/InvasionFront_CD8_block12_x4_y5_patient584_1.json b/584/InvasionFront_CD8_block12_x4_y5_patient584_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3e39eadda91f2f79f47421d07f8e90ace55f3e0 --- /dev/null +++ b/584/InvasionFront_CD8_block12_x4_y5_patient584_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14567.3, + "Centroid Y µm": 16141.5, + "Num Detections": 22392, + "Num Negative": 22314, + "Num Positive": 78, + "Positive %": 0.3483, + "Num Positive per mm^2": 28.45 + } +} \ No newline at end of file diff --git a/584/TumorCenter_CD3_block12_x3_y5_patient584_0.json b/584/TumorCenter_CD3_block12_x3_y5_patient584_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0ab095872b98a95d07012800cb031590151c7fd6 --- /dev/null +++ b/584/TumorCenter_CD3_block12_x3_y5_patient584_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 12443.4, + "Num Detections": 22815, + "Num Negative": 22212, + "Num Positive": 603, + "Positive %": 2.643, + "Num Positive per mm^2": 227.6 + } +} \ No newline at end of file diff --git a/584/TumorCenter_CD3_block12_x4_y5_patient584_1.json b/584/TumorCenter_CD3_block12_x4_y5_patient584_1.json new file mode 100644 index 0000000000000000000000000000000000000000..542e3bfa57481f61bd24d251415eb292f4cec03b --- /dev/null +++ b/584/TumorCenter_CD3_block12_x4_y5_patient584_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 12468.4, + "Num Detections": 23417, + "Num Negative": 22261, + "Num Positive": 1156, + "Positive %": 4.937, + "Num Positive per mm^2": 436.77 + } +} \ No newline at end of file diff --git a/584/TumorCenter_CD8_block12_x3_y5_patient584_0.json b/584/TumorCenter_CD8_block12_x3_y5_patient584_0.json new file mode 100644 index 0000000000000000000000000000000000000000..864b0e2eeb9ab84318cabf835344e1bb0ec03462 --- /dev/null +++ b/584/TumorCenter_CD8_block12_x3_y5_patient584_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14217.5, + "Centroid Y µm": 21838.4, + "Num Detections": 21372, + "Num Negative": 21243, + "Num Positive": 129, + "Positive %": 0.6036, + "Num Positive per mm^2": 48.58 + } +} \ No newline at end of file diff --git a/584/TumorCenter_CD8_block12_x4_y5_patient584_1.json b/584/TumorCenter_CD8_block12_x4_y5_patient584_1.json new file mode 100644 index 0000000000000000000000000000000000000000..16e63be319da622db6e0a6e80add53f3bf501611 --- /dev/null +++ b/584/TumorCenter_CD8_block12_x4_y5_patient584_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 22063.3, + "Num Detections": 17794, + "Num Negative": 17551, + "Num Positive": 243, + "Positive %": 1.366, + "Num Positive per mm^2": 94.96 + } +} \ No newline at end of file diff --git a/584/history_text.txt b/584/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/584/icd_codes.txt b/584/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/584/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/584/ops_codes.txt b/584/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ea0172bae8523b0a08375beb811266c3b20ccd6b --- /dev/null +++ b/584/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Rhinoskopie[1-612 ] Permanente Tracheostomie: Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Destruktion: Elektrokoagulation[5-250.30 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Destruktion: Sonstige[5-250.3x ] Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] \ No newline at end of file diff --git a/584/patient_clinical_data.json b/584/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f68c63cb2fdfc5c2cecd45894cdf047828aad0b0 --- /dev/null +++ b/584/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 52, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/584/patient_pathological_data.json b/584/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6ff1ded34e52b0b163a14a8f6ac0b2492bc99eef --- /dev/null +++ b/584/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "584", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/584/surgery_description.txt b/584/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..53b6967e7c300c012b7ed663cb00f83781ba6063 --- /dev/null +++ b/584/surgery_description.txt @@ -0,0 +1 @@ +Enorale Resektion, Tracheotomie diff --git a/584/surgery_report.txt b/584/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..876a63005d9bd0c7259eaa750f7acf6e90af0b91 --- /dev/null +++ b/584/surgery_report.txt @@ -0,0 +1 @@ +First, repeated endoscopy of the oral cavity and oropharynx. From this aspect, this mass appears to be resectable enorally. Demonstration to , who agrees with this procedure. Now open the oropharynx. Reinforcement of the tongue with a suture. The tumor is now removed from the area of the tongue with continuous digital palpation using the electronic needle and scissors. The entire tumor is sent for frozen section diagnostics. A left tumor tonsillectomy is now performed and a cranio-lateral left mucosal bridge is included in the tumor tonsillectomy. The posterior palatal arch on the left is still in place. Also the uvula and the entire right soft palate. The histologic frozen section diagnosis now shows dysplasia up to carcinoma in situ in the area of the cranio-lateral tonsil preparation. Carcinoma infiltrates can still be seen in the area of the medial tongue and base of the tongue marked with sutures. A re-excision and frozen section samples are now taken from the area of the left tonsil, from the cranio-lateral resection on the left. The entire slice from ventral to dorsal is also excised again from the end of the tongue and submitted for frozen section diagnostics. The frozen section diagnosis now reveals an R0 situation. The tongue is then adapted. Regarding the further procedure, a neck dissection should be performed bilaterally in 14 days. The patient should also be given swallowing training. Conclusion: Endaural tumor resection and tracheotomy for cT3 oral cavity oropharyngeal sidewall carcinoma on the left (tongue margin, tongue base and left tonsil region). The patient was to have a neck dissection on both sides in 2 weeks. In the meantime, the patient should be fed via a PEG tube or receive swallowing training. Tracheotomy (, alternately): Transverse incision 2 QF below the cricoid cartilage, transection of the subcutaneous tissue, identification of the prelaryngeal musculature which is pushed to one side. Identification of the thyroid isthmus, which is separated on the right and left. Cut through the thyroid isthmus and tie it off. The trachea is then incised between the 2nd and 3rd tracheal cartilage and a Björk flap is formed. A plastic stable tracheostoma is then created. \ No newline at end of file diff --git a/585/InvasionFront_CD3_block9_x3_y2_patient585_0.json b/585/InvasionFront_CD3_block9_x3_y2_patient585_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de8b32411055e9d0ea4d749ca19c0531bbfc13dd --- /dev/null +++ b/585/InvasionFront_CD3_block9_x3_y2_patient585_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 5547.1, + "Num Detections": 31604, + "Num Negative": 30807, + "Num Positive": 797, + "Positive %": 2.522, + "Num Positive per mm^2": 283.5 + } +} \ No newline at end of file diff --git a/585/InvasionFront_CD3_block9_x4_y2_patient585_1.json b/585/InvasionFront_CD3_block9_x4_y2_patient585_1.json new file mode 100644 index 0000000000000000000000000000000000000000..22bd46a0bf76b27714b0eabeb84a57a019b65d8a --- /dev/null +++ b/585/InvasionFront_CD3_block9_x4_y2_patient585_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 5722.0, + "Num Detections": 18116, + "Num Negative": 17041, + "Num Positive": 1075, + "Positive %": 5.934, + "Num Positive per mm^2": 541.53 + } +} \ No newline at end of file diff --git a/585/InvasionFront_CD8_block9_x3_y2_patient585_0.json b/585/InvasionFront_CD8_block9_x3_y2_patient585_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c95bc382ee560d9351e19e25a337020703729066 --- /dev/null +++ b/585/InvasionFront_CD8_block9_x3_y2_patient585_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 9844.8, + "Num Detections": 32588, + "Num Negative": 30385, + "Num Positive": 2203, + "Positive %": 6.76, + "Num Positive per mm^2": 797.78 + } +} \ No newline at end of file diff --git a/585/InvasionFront_CD8_block9_x4_y2_patient585_1.json b/585/InvasionFront_CD8_block9_x4_y2_patient585_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67473e01296c7d900dbce67fbe50384048a6ea4c --- /dev/null +++ b/585/InvasionFront_CD8_block9_x4_y2_patient585_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15616.7, + "Centroid Y µm": 9869.8, + "Num Detections": 18271, + "Num Negative": 16922, + "Num Positive": 1349, + "Positive %": 7.383, + "Num Positive per mm^2": 719.26 + } +} \ No newline at end of file diff --git a/585/TumorCenter_CD3_block9_x3_y2_patient585_0.json b/585/TumorCenter_CD3_block9_x3_y2_patient585_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a5dfa6220f01ef15906ee7c7f2e6729a53762e0 --- /dev/null +++ b/585/TumorCenter_CD3_block9_x3_y2_patient585_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 10669.4, + "Num Detections": 25793, + "Num Negative": 17753, + "Num Positive": 8040, + "Positive %": 31.17, + "Num Positive per mm^2": 2849.7 + } +} \ No newline at end of file diff --git a/585/TumorCenter_CD3_block9_x4_y2_patient585_1.json b/585/TumorCenter_CD3_block9_x4_y2_patient585_1.json new file mode 100644 index 0000000000000000000000000000000000000000..11fe8e6e27723f599e2668e3da134a43eeebc332 --- /dev/null +++ b/585/TumorCenter_CD3_block9_x4_y2_patient585_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14367.4, + "Centroid Y µm": 10719.3, + "Num Detections": 27817, + "Num Negative": 18388, + "Num Positive": 9429, + "Positive %": 33.9, + "Num Positive per mm^2": 3244.7 + } +} \ No newline at end of file diff --git a/585/TumorCenter_CD8_block9_x3_y2_patient585_0.json b/585/TumorCenter_CD8_block9_x3_y2_patient585_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0fd60d0387e0d2af520e9b48a15ed58e24670df4 --- /dev/null +++ b/585/TumorCenter_CD8_block9_x3_y2_patient585_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 5647.0, + "Num Detections": 25129, + "Num Negative": 11880, + "Num Positive": 13249, + "Positive %": 52.72, + "Num Positive per mm^2": 4598.7 + } +} \ No newline at end of file diff --git a/585/TumorCenter_CD8_block9_x4_y2_patient585_1.json b/585/TumorCenter_CD8_block9_x4_y2_patient585_1.json new file mode 100644 index 0000000000000000000000000000000000000000..efdf0d1a28fb5d38feb1d6f16773ade2b75deba2 --- /dev/null +++ b/585/TumorCenter_CD8_block9_x4_y2_patient585_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 5472.1, + "Num Detections": 27640, + "Num Negative": 12931, + "Num Positive": 14709, + "Positive %": 53.22, + "Num Positive per mm^2": 5104.1 + } +} \ No newline at end of file diff --git a/585/history_text.txt b/585/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..977fbfdc8b8984d4d518fe30912e3e24e4dc8446 --- /dev/null +++ b/585/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the vallecula/base of tongue area. The tumor is mainly located on the left side, but also extends over the midline and in the direction of the pharyngeal epiglottic plica towards the tonsillar lobe. \ No newline at end of file diff --git a/585/icd_codes.txt b/585/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed4aa87497852c75f601688357848e31931e81a2 --- /dev/null +++ b/585/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/585/ops_codes.txt b/585/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3e7677df0c0f22dad36c3b73ca574323b9e273dd --- /dev/null +++ b/585/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/585/patient_clinical_data.json b/585/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b3144e90cce00bbdc9f2f60b74410a6751de93b8 --- /dev/null +++ b/585/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 69, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/585/patient_pathological_data.json b/585/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8c30f0ee414f3e3b4e53950bd6a099beafe53a51 --- /dev/null +++ b/585/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "585", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 48, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/585/surgery_description.txt b/585/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a98e2b8652e530e0a12d2975f7ff54d7000ade9a --- /dev/null +++ b/585/surgery_description.txt @@ -0,0 +1 @@ +Pharyngoskopie, Laryngoskopie, Laserresektion, Neck dissection diff --git a/585/surgery_report.txt b/585/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e3b6f575866c1debc95fb0c24ca101f777639483 --- /dev/null +++ b/585/surgery_report.txt @@ -0,0 +1 @@ +First of all, pharyngoscopy and laryngoscopy again: The tumor appears as described. Tumor relatively flat, but extending towards the left plica pharyngo epiglottica. Mainly located at the base of the tongue on the left paramedian side with extensions to both sides. Laser resection of the tumor now follows: tumor is adjusted alternately with spreading laryngoscope, tonsil retractor and retractor. Good exposure. Start with right lateral resection. Here removal of marginal sample. Then resection left lateral as on the opposite side with approx. 0.5 -1 cm distance to the microscopically visible tumor. Subsequently, a left lateral margin sample is also taken. Then removal of the tumor from cranial to caudal. The lingual epiglottis and vallecula are also resected caudally. Removal of the tumor in one piece. Suture marking of the tumor with several sutures. Sending for frozen section. Tumor completely removed in sano. Also marginal samples in sano, thus overall R0 situation. Careful hemostasis. PEG placement, tracheostomy placement and neck dissection on both sides by . Subsequent decision to perform flexible esophagogastroscopy for PEG placement in the typical manner. Insertion of the endoscope up to the stomach and placement of the PEG tube using the thread pull-through method in the typical manner. Now perform a plastic tracheotomy. Make an incision directly below the level of the cricoid cartilage, approx. 3 cm long. Cut through the subcutaneous tissue. Expose the prelaryngeal musculature and push it aside. Exposure of the anterior surface of the thyroid isthmus. Undermining of the thyroid isthmus. Separation of the thyroid muscle and ligation of both thyroid stumps. Exposure of the anterior wall of the trachea. Creation of an incision between the 2nd and 3rd tracheal cartilage clasp. Creation of a Björk flap in a typical manner. Epithelialization of the tracheostoma and reintubation with a size 8 Rügheim cannula. The patient is then repositioned for a neck dissection, initially on the right side. Creation of an incision along the anterior border of the sternocleidomastoid muscle. Cut through the subcutaneous tissue. Separation of the platysma. Formation of a platysma flap and exposure of the anterior margin of the sternocleidomastoid muscle. Dissection along the anterior margin. Exposure of the accessorius nerve. Exposure of the digastric muscle cranially and the omohyoid muscle caudally. Exposure of the internal jugular vein. Dissection along it and dissection along the cervical vascular sheath. Successive removal of the posterior neck preparation while sparing the above-mentioned structures. Protection of the plexus branches. Subsequent successive removal of the anterior neck specimen. Hemostasis using bipolar coagulation. Removal of the capsule of the submandibular gland. Exposure in the depth of the hypoglossal nerve. Exposure and protection of the cervical sinus. Creation of a Redon drainage. Two-layer wound closure. Now repositioning of the patient to perform a neck dissection on the left side. Identical procedure here. Creation of a skin incision along the anterior border of the sternocleidomastoid muscle. Cut through the skin, the subcutaneous tissue and the platysma. Exposure of the anterior border of the sternocleidomastoid muscle. Dissection along the same. Exposure of the nervus accessorius, the digaster muscle and the omohyoid muscle. Exposure and removal of the capsule of the submandibular gland. Successive evacuation of the posterior neck preparation in a typical manner, sparing the deep plexus branches. Exposure of the hypoglossal nerve between the internal jugular vein and facial vein. Successive removal of the anterior neck preparation. Hemostasis using bipolar coagulation. Creation of a Redon drainage. Two-layer wound closure. Application of a pressure dressing and completion of the procedure without complications. Nutrition for at least 1 week via an inserted PEG tube, followed by a cautious attempt to rebuild the diet and, if necessary, initiation of swallowing training. Further procedure after final histology, discussion of adjuvant therapy at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/586/InvasionFront_CD3_block18_x5_y4_patient586_0.json b/586/InvasionFront_CD3_block18_x5_y4_patient586_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b707f3b6eb0010120bef086d9c99e2968cca2870 --- /dev/null +++ b/586/InvasionFront_CD3_block18_x5_y4_patient586_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 14942.1, + "Num Detections": 16915, + "Num Negative": 16652, + "Num Positive": 263, + "Positive %": 1.555, + "Num Positive per mm^2": 140.31 + } +} \ No newline at end of file diff --git a/586/InvasionFront_CD3_block18_x6_y4_patient586_1.json b/586/InvasionFront_CD3_block18_x6_y4_patient586_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32dcf80915203e8ea829a72e1769d157c28e853f --- /dev/null +++ b/586/InvasionFront_CD3_block18_x6_y4_patient586_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 15117.0, + "Num Detections": 13621, + "Num Negative": 13360, + "Num Positive": 261, + "Positive %": 1.916, + "Num Positive per mm^2": 145.89 + } +} \ No newline at end of file diff --git a/586/InvasionFront_CD8_block18_x5_y4_patient586_0.json b/586/InvasionFront_CD8_block18_x5_y4_patient586_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d0969b8d83d2342a8639fa24e8a6e46fa1258b73 --- /dev/null +++ b/586/InvasionFront_CD8_block18_x5_y4_patient586_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16450.9, + "Centroid Y µm": 17892.5, + "Num Detections": 14271, + "Num Negative": 14148, + "Num Positive": 123, + "Positive %": 0.8619, + "Num Positive per mm^2": 67.74 + } +} \ No newline at end of file diff --git a/586/InvasionFront_CD8_block18_x6_y4_patient586_1.json b/586/InvasionFront_CD8_block18_x6_y4_patient586_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9cc6bcae30e12ebac9847d35c595b18ea6abac80 --- /dev/null +++ b/586/InvasionFront_CD8_block18_x6_y4_patient586_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18990.4, + "Centroid Y µm": 17956.4, + "Num Detections": 14139, + "Num Negative": 13994, + "Num Positive": 145, + "Positive %": 1.026, + "Num Positive per mm^2": 82.64 + } +} \ No newline at end of file diff --git a/586/TumorCenter_CD3_block18_x5_y4_patient586_0.json b/586/TumorCenter_CD3_block18_x5_y4_patient586_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d985393da6c7f86342d07ae188c254e8179160d --- /dev/null +++ b/586/TumorCenter_CD3_block18_x5_y4_patient586_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15756.3, + "Centroid Y µm": 9875.8, + "Num Detections": 8854, + "Num Negative": 8805, + "Num Positive": 49, + "Positive %": 0.5534, + "Num Positive per mm^2": 32.37 + } +} \ No newline at end of file diff --git a/586/TumorCenter_CD3_block18_x6_y4_patient586_1.json b/586/TumorCenter_CD3_block18_x6_y4_patient586_1.json new file mode 100644 index 0000000000000000000000000000000000000000..78484b7dccd03f2ca3aad2a318793aff1fba1e49 --- /dev/null +++ b/586/TumorCenter_CD3_block18_x6_y4_patient586_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18184.8, + "Centroid Y µm": 9843.0, + "Num Detections": 9245, + "Num Negative": 9209, + "Num Positive": 36, + "Positive %": 0.3894, + "Num Positive per mm^2": 23.92 + } +} \ No newline at end of file diff --git a/586/TumorCenter_CD8_block18_x5_y4_patient586_0.json b/586/TumorCenter_CD8_block18_x5_y4_patient586_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30dd1b079a2c9806f75ccea2e0e80830e34ad84a --- /dev/null +++ b/586/TumorCenter_CD8_block18_x5_y4_patient586_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 10519.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/586/TumorCenter_CD8_block18_x6_y4_patient586_1.json b/586/TumorCenter_CD8_block18_x6_y4_patient586_1.json new file mode 100644 index 0000000000000000000000000000000000000000..215ddb04dfb3dc413cf27591e03d16f13abb4412 --- /dev/null +++ b/586/TumorCenter_CD8_block18_x6_y4_patient586_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 10569.4, + "Num Detections": 14183, + "Num Negative": 14141, + "Num Positive": 42, + "Positive %": 0.2961, + "Num Positive per mm^2": 25.92 + } +} \ No newline at end of file diff --git a/586/history_text.txt b/586/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..19ae5b351be0ba151c087b1f13710c10411ef16d --- /dev/null +++ b/586/history_text.txt @@ -0,0 +1 @@ +The patient reported a history of dysphonia that had been present for 8 weeks. No B-symptomatics, no dysphagia. Nicotine abstinence for 5 years with Z.n. approx. 50 py. In 2008, a panendoscopy and ablation of 2 space-occupying lesions in the left posterior pharyngeal wall and left posterior pharyngeal/hypopharyngeal wall had already been performed. At that time there was no histological evidence of malignancy. Lupenlaryngoscopy currently shows an unclear mass in the area of the vocal fold on the right. Therefore, there is an indication for the above-mentioned operation. \ No newline at end of file diff --git a/586/icd_codes.txt b/586/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d8456abbcb045903d98ccc06178f4333cc4d900 --- /dev/null +++ b/586/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung der Glottis[D38.0 ] Zyste der Vallecula epiglottica[J38.7 ] \ No newline at end of file diff --git a/586/ops_codes.txt b/586/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..65079a397b3c8c6fb17ffeb199be3b0cff060f10 --- /dev/null +++ b/586/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Mikrolaryngoskopie mit Polypentfernung[5-300.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Lokale Exzision am Pharynx[5-292.0 ] Diagnostische Ösophagogastroskopie[1-631.y ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/586/patient_clinical_data.json b/586/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..62268d87678efc8fd4fe3c9c972dbffdd3b7ed9b --- /dev/null +++ b/586/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/586/patient_pathological_data.json b/586/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0211a9de0c71ebd93d3e524a84f3b3106c8c8f69 --- /dev/null +++ b/586/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "586", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 9, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/586/surgery_description.txt b/586/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0de0603b13f759251ba319ba1b1560bd724d4fc --- /dev/null +++ b/586/surgery_description.txt @@ -0,0 +1 @@ +Exzision RF Glottis rechts, Panendo, MLE diff --git a/586/surgery_report.txt b/586/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8892624f27eb5d60533d044f0886c840d9849c79 --- /dev/null +++ b/586/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia colleague. Tracheoscopy is performed with 0° optics. The trachea is visible up to the bifurcation, no evidence of a tumor or pathological mass. In the posterior region of the middle third of the vocal folds on the right side, the papillomatous, broad-based mass is visible. Otherwise non-irritated vocal folds on both sides. The surgeon performs intubation without complications. Positioning of the patient and start of esophagogastroscopy. Careful advancement through the esophagus into the stomach while carefully protecting the patient's remaining teeth. Orienting endoscopy in the stomach. The inversion reveals a non-irritated mucosa, no evidence of a tumor, no evidence of bleeding. Aspiration of the air and careful reflection back through the esophagus with constant air insufflation. Irritation-free mucosal conditions here too. Start with panendoscopy. Careful entry with the size C small bore tube. Orienting inspection of the oral cavity. In the case of post-TE, the mucous membrane is non-irritated, the tongue is smooth and there is no evidence of a tumor. Only in the area of the oral vestibule, in the area of the incisors/upper jaw, is there a slightly hyperplastic mucosa, most likely a pressure point of the prosthesis. This does not appear to be suspicious for malignancy. Mirroring into the oropharynx. Irritation-free mucosal conditions here as well. Only the left vallecula shows a retention cyst. This was completely removed. Insertion of a suprarenin-soaked swab. Short wait. The blood is dry. Sinus piriformes can be freely unfolded on both sides, no evidence of tumor. Postcricoid mucosa without irritation. Lingual epiglottis without irritation. The laryngeal epiglottis is also without irritation. Endolaryngeal mucosa without irritation. Now adjusting the glottic plane with the aid of the microscope. This shows the previously described papillomatous, broad-based mass in the posterior region of the middle third of the vocal fold on the right. It hangs on the free edge of the vocal fold and extends to the lower edge of the glottic plane. Primarily not typically suspicious for malignancy. The papillomatous mass is removed sharply at the margins, carefully preserving the vocal ligament. On palpation, there is a slight adhesion of the mass to the vocal ligament. Since, in consultation with , the mass does not appear to be primarily suspicious for malignancy, the vocal ligament is carefully preserved. The tissue is sent for histological processing. Insertion of a suprarenin-soaked swab. Short wait. The blood is dry. After re-inspection of the sampling site, there is no bleeding. The procedure is therefore completed without complications due to dry blood. Final consultation with the anesthesia colleague. Conclusion: Panendoscopy without complications with removal of a left vallecula cyst and removal of an unclear glottic mass on the right. The tissue is sent for histological processing. The findings on the vocal fold on the right do not appear to be primarily suspicious of malignancy microscopically, which is why care is primarily taken to completely spare the vocal ligament during resection. However, if the findings reveal a malignancy, a subsequent resection will certainly be necessary. This can be carried out using a laser if the setting is very good. \ No newline at end of file diff --git a/587/InvasionFront_CD3_block17_x5_y4_patient587_0.json b/587/InvasionFront_CD3_block17_x5_y4_patient587_0.json new file mode 100644 index 0000000000000000000000000000000000000000..64a309519623f338ee116ff8f013c42568ed29e4 --- /dev/null +++ b/587/InvasionFront_CD3_block17_x5_y4_patient587_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 15241.9, + "Num Detections": 21409, + "Num Negative": 20070, + "Num Positive": 1339, + "Positive %": 6.254, + "Num Positive per mm^2": 506.44 + } +} \ No newline at end of file diff --git a/587/InvasionFront_CD3_block17_x6_y4_patient587_1.json b/587/InvasionFront_CD3_block17_x6_y4_patient587_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c8a06467f8b578c196ab4ad5562e7000ec40b543 --- /dev/null +++ b/587/InvasionFront_CD3_block17_x6_y4_patient587_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 15316.9, + "Num Detections": 21077, + "Num Negative": 19888, + "Num Positive": 1189, + "Positive %": 5.641, + "Num Positive per mm^2": 454.31 + } +} \ No newline at end of file diff --git a/587/InvasionFront_CD8_block17_x5_y4_patient587_0.json b/587/InvasionFront_CD8_block17_x5_y4_patient587_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d7659c7f99cbbb5931c9475509a34441dcda5806 --- /dev/null +++ b/587/InvasionFront_CD8_block17_x5_y4_patient587_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 10419.5, + "Num Detections": 22349, + "Num Negative": 19970, + "Num Positive": 2379, + "Positive %": 10.64, + "Num Positive per mm^2": 920.65 + } +} \ No newline at end of file diff --git a/587/InvasionFront_CD8_block17_x6_y4_patient587_1.json b/587/InvasionFront_CD8_block17_x6_y4_patient587_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c32eb54dc24a86b9023a3ca383bab73aeba76bd4 --- /dev/null +++ b/587/InvasionFront_CD8_block17_x6_y4_patient587_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 10369.5, + "Num Detections": 21363, + "Num Negative": 20246, + "Num Positive": 1117, + "Positive %": 5.229, + "Num Positive per mm^2": 428.54 + } +} \ No newline at end of file diff --git a/587/TumorCenter_CD3_block17_x5_y4_patient587_0.json b/587/TumorCenter_CD3_block17_x5_y4_patient587_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a78321242ce7ca733e6f31726504234ec614f39 --- /dev/null +++ b/587/TumorCenter_CD3_block17_x5_y4_patient587_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 10069.7, + "Num Detections": 20139, + "Num Negative": 18746, + "Num Positive": 1393, + "Positive %": 6.917, + "Num Positive per mm^2": 548.34 + } +} \ No newline at end of file diff --git a/587/TumorCenter_CD3_block17_x6_y4_patient587_1.json b/587/TumorCenter_CD3_block17_x6_y4_patient587_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f438f1807c844d5c95fe73068532cb91a61ee159 --- /dev/null +++ b/587/TumorCenter_CD3_block17_x6_y4_patient587_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 10069.7, + "Num Detections": 15331, + "Num Negative": 14772, + "Num Positive": 559, + "Positive %": 3.646, + "Num Positive per mm^2": 244.37 + } +} \ No newline at end of file diff --git a/587/TumorCenter_CD8_block17_x5_y4_patient587_0.json b/587/TumorCenter_CD8_block17_x5_y4_patient587_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b3a4de5088c9c7b2aa40ba5f389f8b90e704be4 --- /dev/null +++ b/587/TumorCenter_CD8_block17_x5_y4_patient587_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 23587.5, + "Num Detections": 20483, + "Num Negative": 19787, + "Num Positive": 696, + "Positive %": 3.398, + "Num Positive per mm^2": 279.74 + } +} \ No newline at end of file diff --git a/587/TumorCenter_CD8_block17_x6_y4_patient587_1.json b/587/TumorCenter_CD8_block17_x6_y4_patient587_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e55ecdda6116dbddb1ba91f76bc9a0536c706851 --- /dev/null +++ b/587/TumorCenter_CD8_block17_x6_y4_patient587_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21263.7, + "Centroid Y µm": 23462.6, + "Num Detections": 12529, + "Num Negative": 12468, + "Num Positive": 61, + "Positive %": 0.4869, + "Num Positive per mm^2": 31.0 + } +} \ No newline at end of file diff --git a/587/history_text.txt b/587/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/587/icd_codes.txt b/587/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/587/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/587/ops_codes.txt b/587/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c046baae424271933dd935851ed48e360d1055e9 --- /dev/null +++ b/587/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/587/patient_clinical_data.json b/587/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d22d7539ab724e9f1e0404b12a1a3bec5d24d53c --- /dev/null +++ b/587/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 41, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/587/patient_pathological_data.json b/587/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..99e42ed99464e20dfa96c3d0b2c746cf16313b88 --- /dev/null +++ b/587/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "587", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/587/surgery_description.txt b/587/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c871d926af0c159093b255520eeb8db5687d611 --- /dev/null +++ b/587/surgery_description.txt @@ -0,0 +1 @@ +Laser-Chordektomie rechts diff --git a/587/surgery_report.txt b/587/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..88f2b473936b6505fee8a5f813cfa94b1a147ddd --- /dev/null +++ b/587/surgery_report.txt @@ -0,0 +1 @@ +The patient has an externally confirmed squamous cell carcinoma of the right vocal fold. Mirror endoscopy revealed an exophytic protrusion in the area of the entire right vocal fold. No vocal fold stagnation, inspectorically no involvement of the arytenoid region. Ventrally, the mass approaches the anterior commissure. Transfer of the patient to the operating room and preliminary consultation with the anesthesia colleagues. Induction of intubation anesthesia by the colleagues and rigid 0° tracheoscopy by the surgeon. No abnormalities here. The gastroscopy is now performed with the flexible instrument in the usual manner without any abnormalities. Inspection of the hypopharynx after inserting the mouth guard and entering with the small bore tube. The piriform sinus can be freely unfolded on both sides and is free of masses, as are the postcricoid region, the supraglottis and the base of the tongue. Now charge the epiglottis and inspect the glottis. This reveals a clear exophytic mass in the area of the right vocal fold, which extends to the anterior commissure. The tumor did not spread to the left vocal fold. The tumor is now positioned in the area of the anterior commissure and carefully loosened with the CO2 laser. The tumor is successively pulled mediodorsally so that the resection is performed directly on the thyroid cartilage. Now also inspect the postcricoid region, after moving the small bore tube and the support autoscopy, detach from the vocal process, taking it with you, and medialize the tumour with the double spoon. Now detach the lateral border in the direction of the morgue sinus. Macroscopically, the tumor can be safely laser resected at a distance of at least 5 mm. After complete removal, even after cutting through the mucosa in the subglottic area, a safe tumor resection has been performed macroscopically. The tumor is marked with sutures and sent for frozen section diagnostics. This reveals a margin-forming tumor with involvement in the area of the lateral resection margin towards the morgue sinus. Inclusion of and renewed resection of the remaining structures in the area of the morgue sinus. The thyroid cartilage is now completely exposed. After resubmission of the specimen obtained for frozen section histological assessment, no further tumor infestation was found. An R0 resection can therefore be assumed. Subtle hemostasis using a monopolar aspirator and waiting until there is no more blood (approx. 1 hour during the frozen section break). Shortly before the end of the operation, re-inspection with the small water tube, no further bleeding. Summary: Laser resection of a T1a glottic carcinoma on the right side, in frozen section R0. Please await the final histopathological assessment and case discussion in the interdisciplinary tumor conference. A control panendoscopy should be performed in 6-8 weeks. \ No newline at end of file diff --git a/588/InvasionFront_CD3_block16_x3_y8_patient588_0.json b/588/InvasionFront_CD3_block16_x3_y8_patient588_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0a62c02b73b35bcae769299025b6330962823369 --- /dev/null +++ b/588/InvasionFront_CD3_block16_x3_y8_patient588_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11803.0, + "Centroid Y µm": 24468.1, + "Num Detections": 20771, + "Num Negative": 18964, + "Num Positive": 1807, + "Positive %": 8.7, + "Num Positive per mm^2": 696.37 + } +} \ No newline at end of file diff --git a/588/InvasionFront_CD3_block16_x4_y8_patient588_1.json b/588/InvasionFront_CD3_block16_x4_y8_patient588_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a725c8ac274f3440ba50319a566e1a3cbdc27f7 --- /dev/null +++ b/588/InvasionFront_CD3_block16_x4_y8_patient588_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14303.6, + "Centroid Y µm": 24521.0, + "Num Detections": 10382, + "Num Negative": 8945, + "Num Positive": 1437, + "Positive %": 13.84, + "Num Positive per mm^2": 1000.8 + } +} \ No newline at end of file diff --git a/588/InvasionFront_CD8_block16_x3_y8_patient588_0.json b/588/InvasionFront_CD8_block16_x3_y8_patient588_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e9a62dd5e60f80ce4b7bd0ed5614e542b127aa8f --- /dev/null +++ b/588/InvasionFront_CD8_block16_x3_y8_patient588_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10912.3, + "Centroid Y µm": 19540.3, + "Num Detections": 20723, + "Num Negative": 16868, + "Num Positive": 3855, + "Positive %": 18.6, + "Num Positive per mm^2": 1492.3 + } +} \ No newline at end of file diff --git a/588/InvasionFront_CD8_block16_x4_y8_patient588_1.json b/588/InvasionFront_CD8_block16_x4_y8_patient588_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06ae4e176cb2c00f7e386dac5f7b0c1e96232ebf --- /dev/null +++ b/588/InvasionFront_CD8_block16_x4_y8_patient588_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 19705.7, + "Num Detections": 7240, + "Num Negative": 6484, + "Num Positive": 756, + "Positive %": 10.44, + "Num Positive per mm^2": 812.91 + } +} \ No newline at end of file diff --git a/588/TumorCenter_CD3_block16_x3_y8_patient588_0.json b/588/TumorCenter_CD3_block16_x3_y8_patient588_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6500e168b5511034ebc721739dfb40d5835cbfd1 --- /dev/null +++ b/588/TumorCenter_CD3_block16_x3_y8_patient588_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11468.9, + "Centroid Y µm": 20514.1, + "Num Detections": 16387, + "Num Negative": 15934, + "Num Positive": 453, + "Positive %": 2.764, + "Num Positive per mm^2": 187.58 + } +} \ No newline at end of file diff --git a/588/TumorCenter_CD3_block16_x4_y8_patient588_1.json b/588/TumorCenter_CD3_block16_x4_y8_patient588_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f22cf4598670502d37d95bc2c78e53b65327df45 --- /dev/null +++ b/588/TumorCenter_CD3_block16_x4_y8_patient588_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 20614.1, + "Num Detections": 14872, + "Num Negative": 14785, + "Num Positive": 87, + "Positive %": 0.585, + "Num Positive per mm^2": 41.03 + } +} \ No newline at end of file diff --git a/588/TumorCenter_CD8_block16_x3_y8_patient588_0.json b/588/TumorCenter_CD8_block16_x3_y8_patient588_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f2867baa297ad089b5180add47111ad413a235d8 --- /dev/null +++ b/588/TumorCenter_CD8_block16_x3_y8_patient588_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 20464.2, + "Num Detections": 17560, + "Num Negative": 17066, + "Num Positive": 494, + "Positive %": 2.813, + "Num Positive per mm^2": 211.59 + } +} \ No newline at end of file diff --git a/588/TumorCenter_CD8_block16_x4_y8_patient588_1.json b/588/TumorCenter_CD8_block16_x4_y8_patient588_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7ea6318463df54818fb9973769d039d4fd4623f5 --- /dev/null +++ b/588/TumorCenter_CD8_block16_x4_y8_patient588_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 20564.1, + "Num Detections": 15308, + "Num Negative": 15268, + "Num Positive": 40, + "Positive %": 0.2613, + "Num Positive per mm^2": 20.42 + } +} \ No newline at end of file diff --git a/588/history_text.txt b/588/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d25243bb9e9108042463c9589a98baa6c951d27d --- /dev/null +++ b/588/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tongue margin carcinoma on the left from the middle of the tongue to just before the base of the tongue. Midline not crossed. Panendoscopy performed. Indication is clear. \ No newline at end of file diff --git a/588/icd_codes.txt b/588/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bd499c58a417cfc54de3fb3d79d05e5befa06940 --- /dev/null +++ b/588/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 ] \ No newline at end of file diff --git a/588/ops_codes.txt b/588/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9fe26af11660e95301b276b1951d2060552bb8c6 --- /dev/null +++ b/588/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Diagnostische Ösophagogastroskopie[1-631 ] Perkutane [endoskopische] Gastrostomie [PEG][5-431.2 ] Exzision erkranktes Gewebe äußeres Ohr präaurikulär[5-181.3 L] \ No newline at end of file diff --git a/588/patient_clinical_data.json b/588/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aa68491e26ab4c2ed97c660713370efcaa396361 --- /dev/null +++ b/588/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/588/patient_pathological_data.json b/588/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bb4c4fc51a9f8717abc2426b71396964669cb548 --- /dev/null +++ b/588/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "588", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/588/surgery_description.txt b/588/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1748c636ce8811183324127fb19a212909ef452 --- /dev/null +++ b/588/surgery_description.txt @@ -0,0 +1 @@ +Partielle Glossektomie, Neck diss. bds.; PEG-Anlage diff --git a/588/surgery_report.txt b/588/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad7a8dc3dfefc13b0d08b3bec1b3aee3dacecaee --- /dev/null +++ b/588/surgery_report.txt @@ -0,0 +1 @@ + Tumor resection: First insertion of mouth retractor, followed by tongue tie suture. Using an electric knife and scissors, the tumor is resected macroscopically on all sides with a safety margin of at least 1.5 cm. Resection extends to just below the midline and also includes parts of the base of the tongue and floor of the mouth. Resectate is thread-marked for frozen section assessment. In addition, a lateral margin sample is taken from the alveolar ridge. In the frozen section, all margins after tumor resection in sano also basally. Thus R0 resection. Rearrangement for neck dissection. Dictation Neck dissection: Positioning of the patient by the surgeon. Ablation of the surgical site and sterile draping. As a basal cell carcinoma has already been resected externally in the area of the left helical attachment, the resection is now performed here at the beginning. Marking of the spindle-shaped resection margins. Subsequent spindle-shaped resection of the clinically macroscopically inconspicuous scar. Inferior suture marking before placement of the post-resection. Hemostasis using bipolar coagulation. Now proceed to neck dissection on the left side. Marking of the mandible and the ascending mandibular branch as well as the jugulum. Identify the anterior edge of the sternocleidomastoid muscle by palpation. Mark the planned incision on the anterior belly of the sternocleidomastoid muscle, which extends caudally to the lateral side. Make the skin incision and sharply cut through the subcutaneous fatty tissue. Exposure of the external jugular vein and the auricular nerve. For reasons of clarity, the external jugular vein must be cut off and severed later on. However, the auricular nerve is spared. The sternocleidomastoid muscle is then exposed in its course. Dissection of the omohyoid muscle as the caudal border. Blunt dissection of the same up to the hyoid. The accessorius nerve is then exposed and protected. Dissection of the posterior digastric venter muscle as the cranial border. Proceed to dissection of the cervical vascular sheath. Locate the jugular vein at the level of the omohyoid muscle. Then successive dissection along the internal jugular vein cranially to below the digastric abdomen. This reveals a prominent superior thyroid vein. A typical venous angle with a facial vein is not found here. During the dissection, at least 2 clinically macroscopically suspicious lymph nodes are found in region II and in the area of the superior thyroid vein. It was therefore decided to extend the neck dissection on the left side to 5 regions. Subsequent exposure and protection of the hypoglossal nerve. Meticulous clearing of the accessorius triangle and successive development of the lateral neck preparation. Hemostasis by means of bipolar coagulation. The medial neck preparation is then developed. This also includes exposure of the submandibular gland. After consultation with , the lingual artery is now explored and ligated twice to prevent bleeding. Hemostasis by means of bipolar coagulation. Insertion of a moist abdominal drape. Transition to the right side: Here too, at the beginning of the operation, mark the lower edge of the mandible and the ascending mandibular branch. Make the skin incision in the area of the anterior edge of the sternocleidomastoid muscle, which extends caudally to the lateral side. Sharp dissection of the subcutaneous fatty tissue and exposure of the external jugular vein and the auricular nerve. Both structures can be spared intraoperatively. Exposure of the sternocleidomastoid muscle in its course. Exposure of the omohyoid muscle as the caudal boundary and blunt dissection of the same up to the hyoid. Subsequent exposure and protection of the accessorius nerve and the posterior venter of the digastric muscle. Proceed to dissection of the cervical vascular sheath. Locate the internal jugular vein at the level of the lower edge of the omohyoid muscle. Successive dissection along the jugular vein and visualization of the vein angle. Dissection of the facial vein up to the submandibular gland including resection of the gland capsule. Subsequent exposure of the common carotid artery and the bifurcation. Subsequent entry into level II b for development of the complete lateral neck preparation. This is performed while sparing the plexus branches. After exposing the hypoglossal nerve, the medial neck preparation is then removed. Hemostasis using bipolar coagulation. Irrigation of the wound using H2O2 and NaCl on both sides. Insertion and insertion of a 10 Redon drain and subsequent two-layer wound closure. Intraoperative frozen section analysis of the post-resection in the area of the left helical attachment showed no residual basal cell carcinoma in the processed frozen section preparation. An R0 resection can therefore be assumed here. Therefore, two-layer wound closure in the area of the helical attachment and completion of the operation without complications. Note: This resulted in a neck dissection on the left in the regions level I b, II a, II b, III, IV and V due to the intraoperative macroscopic suspicion of lymph node metastasis in regions II and III. On the right side, the neck was dissected in levels I b, II a, II b, III and IV. The operation was completed without complications. \ No newline at end of file diff --git a/589/InvasionFront_CD3_block9_x1_y12_patient589_0.json b/589/InvasionFront_CD3_block9_x1_y12_patient589_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1892497032fd950a47c7ddf680acbdae3527969 --- /dev/null +++ b/589/InvasionFront_CD3_block9_x1_y12_patient589_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.2, + "Centroid Y µm": 29417.7, + "Num Detections": 19511, + "Num Negative": 18227, + "Num Positive": 1284, + "Positive %": 6.581, + "Num Positive per mm^2": 573.01 + } +} \ No newline at end of file diff --git a/589/InvasionFront_CD3_block9_x2_y12_patient589_1.json b/589/InvasionFront_CD3_block9_x2_y12_patient589_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ae8d65050e25cf210e41a6e4f60085a78ac38f44 --- /dev/null +++ b/589/InvasionFront_CD3_block9_x2_y12_patient589_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6170.1, + "Centroid Y µm": 30074.5, + "Num Detections": 18763, + "Num Negative": 17464, + "Num Positive": 1299, + "Positive %": 6.923, + "Num Positive per mm^2": 587.59 + } +} \ No newline at end of file diff --git a/589/InvasionFront_CD3_block9_x3_y12_patient589_2.json b/589/InvasionFront_CD3_block9_x3_y12_patient589_2.json new file mode 100644 index 0000000000000000000000000000000000000000..d170c468e1bdbb02a4961949dd1eda98e703c2dc --- /dev/null +++ b/589/InvasionFront_CD3_block9_x3_y12_patient589_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 30733.7, + "Num Detections": 13060, + "Num Negative": 12942, + "Num Positive": 118, + "Positive %": 0.9035, + "Num Positive per mm^2": 65.64 + } +} \ No newline at end of file diff --git a/589/InvasionFront_CD3_block9_x4_y12_patient589_3.json b/589/InvasionFront_CD3_block9_x4_y12_patient589_3.json new file mode 100644 index 0000000000000000000000000000000000000000..86ec51f2779b5965dbe93fad023522343b3a29cc --- /dev/null +++ b/589/InvasionFront_CD3_block9_x4_y12_patient589_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13233.1, + "Centroid Y µm": 31172.7, + "Num Detections": 16544, + "Num Negative": 15897, + "Num Positive": 647, + "Positive %": 3.911, + "Num Positive per mm^2": 304.39 + } +} \ No newline at end of file diff --git a/589/InvasionFront_CD8_block9_x1_y12_patient589_0.json b/589/InvasionFront_CD8_block9_x1_y12_patient589_0.json new file mode 100644 index 0000000000000000000000000000000000000000..17dc0f61c03ddda98a792394c8d9d6ed0ad597f6 --- /dev/null +++ b/589/InvasionFront_CD8_block9_x1_y12_patient589_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3815.0, + "Centroid Y µm": 32889.8, + "Num Detections": 18705, + "Num Negative": 17939, + "Num Positive": 766, + "Positive %": 4.095, + "Num Positive per mm^2": 367.18 + } +} \ No newline at end of file diff --git a/589/InvasionFront_CD8_block9_x2_y12_patient589_1.json b/589/InvasionFront_CD8_block9_x2_y12_patient589_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de16c49006e6a79cf6330a33bb520d6a34a025b5 --- /dev/null +++ b/589/InvasionFront_CD8_block9_x2_y12_patient589_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6308.4, + "Centroid Y µm": 33343.3, + "Num Detections": 19304, + "Num Negative": 18509, + "Num Positive": 795, + "Positive %": 4.118, + "Num Positive per mm^2": 383.95 + } +} \ No newline at end of file diff --git a/589/InvasionFront_CD8_block9_x3_y12_patient589_2.json b/589/InvasionFront_CD8_block9_x3_y12_patient589_2.json new file mode 100644 index 0000000000000000000000000000000000000000..5664a32d0b5f7d0b3f6b5ba1363c66ed22f3e5b4 --- /dev/null +++ b/589/InvasionFront_CD8_block9_x3_y12_patient589_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10686.8, + "Centroid Y µm": 34082.6, + "Num Detections": 13343, + "Num Negative": 13292, + "Num Positive": 51, + "Positive %": 0.3822, + "Num Positive per mm^2": 31.87 + } +} \ No newline at end of file diff --git a/589/InvasionFront_CD8_block9_x4_y12_patient589_3.json b/589/InvasionFront_CD8_block9_x4_y12_patient589_3.json new file mode 100644 index 0000000000000000000000000000000000000000..2b783f4e47b9e7edbd10a5ff5fa061d0a4151e82 --- /dev/null +++ b/589/InvasionFront_CD8_block9_x4_y12_patient589_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13316.1, + "Centroid Y µm": 34927.1, + "Num Detections": 19028, + "Num Negative": 17962, + "Num Positive": 1066, + "Positive %": 5.602, + "Num Positive per mm^2": 519.13 + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD3_block9_x1_y12_patient589_0.json b/589/TumorCenter_CD3_block9_x1_y12_patient589_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dcb099870c2a9c3fe3f8e7f33292acb06238075a --- /dev/null +++ b/589/TumorCenter_CD3_block9_x1_y12_patient589_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 35306.3, + "Num Detections": 22799, + "Num Negative": 20919, + "Num Positive": 1880, + "Positive %": 8.246, + "Num Positive per mm^2": 774.6 + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD3_block9_x2_y12_patient589_1.json b/589/TumorCenter_CD3_block9_x2_y12_patient589_1.json new file mode 100644 index 0000000000000000000000000000000000000000..59897acd7004d1efdd8e989e7f2295c4767f653b --- /dev/null +++ b/589/TumorCenter_CD3_block9_x2_y12_patient589_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 35356.3, + "Num Detections": 20307, + "Num Negative": 18407, + "Num Positive": 1900, + "Positive %": 9.356, + "Num Positive per mm^2": 792.11 + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD3_block9_x3_y12_patient589_2.json b/589/TumorCenter_CD3_block9_x3_y12_patient589_2.json new file mode 100644 index 0000000000000000000000000000000000000000..5d79e29cb8d10fd6fddde384ecc7767416f54fd1 --- /dev/null +++ b/589/TumorCenter_CD3_block9_x3_y12_patient589_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 35481.2, + "Num Detections": 17052, + "Num Negative": 13139, + "Num Positive": 3913, + "Positive %": 22.95, + "Num Positive per mm^2": 1793.8 + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD3_block9_x4_y12_patient589_3.json b/589/TumorCenter_CD3_block9_x4_y12_patient589_3.json new file mode 100644 index 0000000000000000000000000000000000000000..962f73d4404a6dbe872cf35b596961c76d9f260f --- /dev/null +++ b/589/TumorCenter_CD3_block9_x4_y12_patient589_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 35431.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD8_block9_x1_y12_patient589_0.json b/589/TumorCenter_CD8_block9_x1_y12_patient589_0.json new file mode 100644 index 0000000000000000000000000000000000000000..91858faf2bb27e2d0d536403c656dc1c6890c121 --- /dev/null +++ b/589/TumorCenter_CD8_block9_x1_y12_patient589_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4347.7, + "Centroid Y µm": 31683.2, + "Num Detections": 25017, + "Num Negative": 23932, + "Num Positive": 1085, + "Positive %": 4.337, + "Num Positive per mm^2": 444.69 + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD8_block9_x2_y12_patient589_1.json b/589/TumorCenter_CD8_block9_x2_y12_patient589_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d20f925303ca3b237a585d0de400c321d3b5602f --- /dev/null +++ b/589/TumorCenter_CD8_block9_x2_y12_patient589_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6946.3, + "Centroid Y µm": 31508.3, + "Num Detections": 21915, + "Num Negative": 20552, + "Num Positive": 1363, + "Positive %": 6.219, + "Num Positive per mm^2": 573.47 + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD8_block9_x3_y12_patient589_2.json b/589/TumorCenter_CD8_block9_x3_y12_patient589_2.json new file mode 100644 index 0000000000000000000000000000000000000000..64dbedba8ef44424d2cb348ce304e394d2236228 --- /dev/null +++ b/589/TumorCenter_CD8_block9_x3_y12_patient589_2.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11818.7, + "Centroid Y µm": 31383.4, + "Num Detections": 13569, + "Num Negative": 9776, + "Num Positive": 3793, + "Positive %": 27.95, + "Num Positive per mm^2": 2062.3 + } +} \ No newline at end of file diff --git a/589/TumorCenter_CD8_block9_x4_y12_patient589_3.json b/589/TumorCenter_CD8_block9_x4_y12_patient589_3.json new file mode 100644 index 0000000000000000000000000000000000000000..442102b90af95f29409be3caee06fd5cd3cb3649 --- /dev/null +++ b/589/TumorCenter_CD8_block9_x4_y12_patient589_3.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 31308.4, + "Num Detections": 14646, + "Num Negative": 12261, + "Num Positive": 2385, + "Positive %": 16.28, + "Num Positive per mm^2": 1258.3 + } +} \ No newline at end of file diff --git a/589/history_text.txt b/589/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/589/icd_codes.txt b/589/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/589/ops_codes.txt b/589/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/589/patient_clinical_data.json b/589/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2b2945ce598c7849684a8568f578ca2c6d01fbda --- /dev/null +++ b/589/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/589/patient_pathological_data.json b/589/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..782e29e8f73ac35e66896d1b0f6df1097bad4f70 --- /dev/null +++ b/589/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "589", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/589/surgery_description.txt b/589/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..587f4e8c2fec8d26fa210ed30cd040bf4025ee78 --- /dev/null +++ b/589/surgery_description.txt @@ -0,0 +1 @@ +Neck dissection bds suprahyoidal, Submandibulektomie bds diff --git a/589/surgery_report.txt b/589/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/590/InvasionFront_CD3_block12_x5_y7_patient590_0.json b/590/InvasionFront_CD3_block12_x5_y7_patient590_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e80ffa0a52b513ab9ca7050d960106631d7b4636 --- /dev/null +++ b/590/InvasionFront_CD3_block12_x5_y7_patient590_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 22563.1, + "Num Detections": 25021, + "Num Negative": 21990, + "Num Positive": 3031, + "Positive %": 12.11, + "Num Positive per mm^2": 1120.6 + } +} \ No newline at end of file diff --git a/590/InvasionFront_CD3_block12_x6_y7_patient590_1.json b/590/InvasionFront_CD3_block12_x6_y7_patient590_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b97ff2c0525877ec9f71ab8ff654fb7d78b58f5d --- /dev/null +++ b/590/InvasionFront_CD3_block12_x6_y7_patient590_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 22787.9, + "Num Detections": 24692, + "Num Negative": 21181, + "Num Positive": 3511, + "Positive %": 14.22, + "Num Positive per mm^2": 1305.5 + } +} \ No newline at end of file diff --git a/590/InvasionFront_CD8_block12_x5_y7_patient590_0.json b/590/InvasionFront_CD8_block12_x5_y7_patient590_0.json new file mode 100644 index 0000000000000000000000000000000000000000..464fd6f44e587107b4d22c446b461f9cd6d39551 --- /dev/null +++ b/590/InvasionFront_CD8_block12_x5_y7_patient590_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17340.8, + "Centroid Y µm": 21113.8, + "Num Detections": 25444, + "Num Negative": 20892, + "Num Positive": 4552, + "Positive %": 17.89, + "Num Positive per mm^2": 1674.5 + } +} \ No newline at end of file diff --git a/590/InvasionFront_CD8_block12_x6_y7_patient590_1.json b/590/InvasionFront_CD8_block12_x6_y7_patient590_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5b1fef30620b9233210cd335ad02c37563bf1736 --- /dev/null +++ b/590/InvasionFront_CD8_block12_x6_y7_patient590_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 21038.9, + "Num Detections": 25335, + "Num Negative": 20955, + "Num Positive": 4380, + "Positive %": 17.29, + "Num Positive per mm^2": 1610.0 + } +} \ No newline at end of file diff --git a/590/TumorCenter_CD3_block12_x5_y7_patient590_0.json b/590/TumorCenter_CD3_block12_x5_y7_patient590_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebf2a146470b1a899b051482926754dc6cf37061 --- /dev/null +++ b/590/TumorCenter_CD3_block12_x5_y7_patient590_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 17540.7, + "Num Detections": 24418, + "Num Negative": 21512, + "Num Positive": 2906, + "Positive %": 11.9, + "Num Positive per mm^2": 1130.0 + } +} \ No newline at end of file diff --git a/590/TumorCenter_CD3_block12_x6_y7_patient590_1.json b/590/TumorCenter_CD3_block12_x6_y7_patient590_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e59ca26234903f2c0e6b30e96ad4ab02bb95ac1 --- /dev/null +++ b/590/TumorCenter_CD3_block12_x6_y7_patient590_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 17640.7, + "Num Detections": 24580, + "Num Negative": 20929, + "Num Positive": 3651, + "Positive %": 14.85, + "Num Positive per mm^2": 1360.8 + } +} \ No newline at end of file diff --git a/590/TumorCenter_CD8_block12_x5_y7_patient590_0.json b/590/TumorCenter_CD8_block12_x5_y7_patient590_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b5dc9c23d537e1e0ed955a389b648aa993ffc6c --- /dev/null +++ b/590/TumorCenter_CD8_block12_x5_y7_patient590_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 27060.7, + "Num Detections": 23943, + "Num Negative": 22173, + "Num Positive": 1770, + "Positive %": 7.393, + "Num Positive per mm^2": 708.16 + } +} \ No newline at end of file diff --git a/590/TumorCenter_CD8_block12_x6_y7_patient590_1.json b/590/TumorCenter_CD8_block12_x6_y7_patient590_1.json new file mode 100644 index 0000000000000000000000000000000000000000..321b411b99d8057a06ca76148d5661a9822cbf0a --- /dev/null +++ b/590/TumorCenter_CD8_block12_x6_y7_patient590_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 27260.6, + "Num Detections": 25673, + "Num Negative": 22267, + "Num Positive": 3406, + "Positive %": 13.27, + "Num Positive per mm^2": 1300.3 + } +} \ No newline at end of file diff --git a/590/history_text.txt b/590/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ee7d86e66c79be36926988fa8947492ccf493291 --- /dev/null +++ b/590/history_text.txt @@ -0,0 +1 @@ +Diagnosis/indication: pT2 cN2b tonsillar carcinoma right \ No newline at end of file diff --git a/590/icd_codes.txt b/590/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e83105e7bf11f6ca52dbd4665319746d4a9a92e --- /dev/null +++ b/590/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/590/ops_codes.txt b/590/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a7a96edde24845eec76d398779f67fe9999658c6 --- /dev/null +++ b/590/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie [ohne Adenotomie] radikal transoral[5-281.2 ] Gaumenbogenkarzinom-Resektion[5-272.1 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/590/patient_clinical_data.json b/590/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6c5594ae945ca4488ee25d3ae9fc5c9d1d63e989 --- /dev/null +++ b/590/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 46, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/590/patient_pathological_data.json b/590/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dca9a6f7f25d26d9e6da11c07d2b31d6ef4962c9 --- /dev/null +++ b/590/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "590", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/590/surgery_description.txt b/590/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..cdf2bd511f4a9fc1e854aff88933c68f1e735342 --- /dev/null +++ b/590/surgery_description.txt @@ -0,0 +1 @@ +Tumortonsillektomie rechts, Tracheotomie, PEG-Anlage diff --git a/590/surgery_report.txt b/590/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1981bb00719da5bfa43730593d221c5ab616fd03 --- /dev/null +++ b/590/surgery_report.txt @@ -0,0 +1 @@ +Operators: , , guest Initially PEG device. Problem-free entry with the flexible esophagoscope. Under diaphanoscopy after infiltration of local anesthetic, insertion into the stomach with the trocar about 2 transverse fingers below the costal arch. Insertion of the PEG tube in the typical manner. Repositioning for tumor tonsillectomy: The ulcerating tumor described above is seen in the area of the right tonsil lobe, which extends far into the base of the tongue Starting at the upper pole of the tonsil, it is now successively detached from the muscles of the palate with the electric knife. Repeated careful hemostasis using bipolar electrocoagulation. The tumor has infiltrated deep into the muscles at the base of the tongue. The lingual artery and vein must be ligated. The tumor was removed en bloc and a resection was performed in the area of the posterior palatal arch, although macroscopically it was not completely free of tumor. Overall, the tumor was removed with a safety margin of 0.5 to 1 cm. Due to the extensive infiltration into the neck musculature, decided not to perform a neck dissection at the same time and to wait for stable wound conditions. After waiting for repeated bipolar coagulation towards the base of the tongue, there is hemostasis. Now repositioning for tracheotomy. After infiltration anesthesia of xylocaine with adrenaline 1 % 1:200 000, skin incision about 2 transverse fingers below the cricoid cartilage. Now dissection of the subcutaneous fatty tissue. Division of the prelaryngeal musculature by entering the linea alba. Exposure of the thyroid isthmus and ligation of a large longitudinal vein. This is undermined with the Overholt and severed by clamping two isthmus clamps in the area of the isthmus. Here, the isthmus is sutured and bipolar electrocoagulation is performed again. Entry into the trachea below the 2nd tracheal cartilage. Creation of a caudally pedicled tracheal flap and incision for epithelialization as well as two skin sutures laterally. Problem-free insertion of an 8-gauge ruffled cannula. Now re-inspection of the tumor bed in the area of the oropharynx. There is no bleeding here. This ends the procedure. Overall extensive tumor in the area of the left tonsil lobe with infiltration into the base of the tongue. Temporary placement of a tracheostoma due to the increased risk of secondary bleeding. Neck dissection and, if necessary, resection in the area of the tumor bed should be performed at intervals of about 10 days. \ No newline at end of file diff --git a/591/InvasionFront_CD3_block6_x1_y7_patient591_0.json b/591/InvasionFront_CD3_block6_x1_y7_patient591_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c83e3506d8ef84819d365469ca180e15bbd6dac --- /dev/null +++ b/591/InvasionFront_CD3_block6_x1_y7_patient591_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4322.7, + "Centroid Y µm": 17765.6, + "Num Detections": 7417, + "Num Negative": 7145, + "Num Positive": 272, + "Positive %": 3.667, + "Num Positive per mm^2": 312.42 + } +} \ No newline at end of file diff --git a/591/InvasionFront_CD3_block6_x2_y7_patient591_1.json b/591/InvasionFront_CD3_block6_x2_y7_patient591_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0f9d8af2f1a28842924784eda9534552526b09d5 --- /dev/null +++ b/591/InvasionFront_CD3_block6_x2_y7_patient591_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7121.2, + "Centroid Y µm": 17965.5, + "Num Detections": 20904, + "Num Negative": 19778, + "Num Positive": 1126, + "Positive %": 5.387, + "Num Positive per mm^2": 464.51 + } +} \ No newline at end of file diff --git a/591/InvasionFront_CD8_block6_x1_y5_patient591_0.json b/591/InvasionFront_CD8_block6_x1_y5_patient591_0.json new file mode 100644 index 0000000000000000000000000000000000000000..da4ce03b3df0a723604637da94a3bf6a26f0d125 --- /dev/null +++ b/591/InvasionFront_CD8_block6_x1_y5_patient591_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4822.4, + "Centroid Y µm": 11868.7, + "Num Detections": 21684, + "Num Negative": 11994, + "Num Positive": 9690, + "Positive %": 44.69, + "Num Positive per mm^2": 3875.7 + } +} \ No newline at end of file diff --git a/591/InvasionFront_CD8_block6_x2_y5_patient591_1.json b/591/InvasionFront_CD8_block6_x2_y5_patient591_1.json new file mode 100644 index 0000000000000000000000000000000000000000..00e9b8d048e930d6006c161f9469b2c7cfd88c1a --- /dev/null +++ b/591/InvasionFront_CD8_block6_x2_y5_patient591_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7546.0, + "Centroid Y µm": 11968.7, + "Num Detections": 21886, + "Num Negative": 19726, + "Num Positive": 2160, + "Positive %": 9.869, + "Num Positive per mm^2": 939.53 + } +} \ No newline at end of file diff --git a/591/TumorCenter_CD3_block6_x1_y5_patient591_0.json b/591/TumorCenter_CD3_block6_x1_y5_patient591_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de9a964e100b56f6e1cae2807bde596801cd828f --- /dev/null +++ b/591/TumorCenter_CD3_block6_x1_y5_patient591_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 12743.3, + "Num Detections": 31556, + "Num Negative": 29211, + "Num Positive": 2345, + "Positive %": 7.431, + "Num Positive per mm^2": 784.68 + } +} \ No newline at end of file diff --git a/591/TumorCenter_CD3_block6_x2_y5_patient591_1.json b/591/TumorCenter_CD3_block6_x2_y5_patient591_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e1d04aeee1934370a1f6c048375b4fd6b6e921cc --- /dev/null +++ b/591/TumorCenter_CD3_block6_x2_y5_patient591_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 12743.3, + "Num Detections": 24895, + "Num Negative": 23146, + "Num Positive": 1749, + "Positive %": 7.026, + "Num Positive per mm^2": 605.73 + } +} \ No newline at end of file diff --git a/591/TumorCenter_CD8_block6_x1_y5_patient591_0.json b/591/TumorCenter_CD8_block6_x1_y5_patient591_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0fed18b3951da47ba6fc56cb20b0adee328b0fd0 --- /dev/null +++ b/591/TumorCenter_CD8_block6_x1_y5_patient591_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 13018.1, + "Num Detections": 35575, + "Num Negative": 34237, + "Num Positive": 1338, + "Positive %": 3.761, + "Num Positive per mm^2": 444.41 + } +} \ No newline at end of file diff --git a/591/TumorCenter_CD8_block6_x2_y5_patient591_1.json b/591/TumorCenter_CD8_block6_x2_y5_patient591_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0fc291b186458e0f1dc242d2e400255715e5e3ba --- /dev/null +++ b/591/TumorCenter_CD8_block6_x2_y5_patient591_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 13068.1, + "Num Detections": 31045, + "Num Negative": 30471, + "Num Positive": 574, + "Positive %": 1.849, + "Num Positive per mm^2": 198.03 + } +} \ No newline at end of file diff --git a/591/history_text.txt b/591/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..421838a51f41876372b7e016b44c16f2eda3b9e7 --- /dev/null +++ b/591/history_text.txt @@ -0,0 +1 @@ +The patient has had a scratchy feeling in the throat on the left side for several weeks. The external ENT colleague carried out a test biopsy in case of tonsillar carcinoma and found evidence of basaloid squamous cell carcinoma. Therefore indication for the above procedure. Computed tomography currently shows cN0 neck status (primary in the tonsil cannot be visualized due to artefacts), sonographically at least a nodus on the opposite side on the right in level II. \ No newline at end of file diff --git a/591/icd_codes.txt b/591/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0eb919f54e1ea594f16fd83c9f763a12f67c6fb --- /dev/null +++ b/591/icd_codes.txt @@ -0,0 +1 @@ +Tonsillenkarzinom[C09.9 L] \ No newline at end of file diff --git a/591/ops_codes.txt b/591/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..14c170aae3bee06faebae0d77d54958bc2cc2fe8 --- /dev/null +++ b/591/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie: Bei normalem Situs[1-631.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/591/patient_clinical_data.json b/591/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..536149435d79e093ff93f9a24cbda47363a0df50 --- /dev/null +++ b/591/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/591/patient_pathological_data.json b/591/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..81dca3349e9394dea43ed09ae5c482866228630f --- /dev/null +++ b/591/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "591", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 55, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/591/surgery_description.txt b/591/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0ae80231c1f71c292d7136c4a515cdc0551d2420 --- /dev/null +++ b/591/surgery_description.txt @@ -0,0 +1 @@ +Tumor-Tonsillektomie, Panendo diff --git a/591/surgery_report.txt b/591/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f5f896a5d0e5fae04f15ea8ee70c88444dfe4e40 --- /dev/null +++ b/591/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is taken to the operating room. Induction of anesthesia and intubation by the anesthesia colleague after an inconspicuous tracheoscopy by the surgeon. Carry out the team time-out. Start of oesophagogastroscopy: problem-free insertion of the endoscope into the oesophagus and advancement into the stomach. Inconspicuous mucosal conditions on all sides. The mucosa in the esophagus is also normal. Then carry out the panendoscopy: first inspect and palpate the oral cavity, tongue, base of the tongue and floor of the mouth. A tumor measuring approx. 1 to 1 ˝ cm is palpated in the left tonsil. Otherwise unremarkable findings. Now insertion of the mouth guard and insertion of the size C small bore tube. Tonsil lobe on the right and base of tongue as well as vallecula with epiglottis are unremarkable. Inconspicuous hypopharynx. Inconspicuous endolarynx. Now irrigation of the endolarynx with sodium chloride by ( study). Then proceed to tumor tonsillectomy on the left side: insertion of the McIvor oral spatula. The carcinoma is exophytic in the lower half of the left tonsil, with no evidence of deep infiltration. Therefore, initially start as for normal tonsillectomy with parauvular mucosal incision and dissection of the capsule. Exposure of the upper pole vessels and bipolar coagulation as well as removal of the upper pole vessels. Then dissect along the capsule up to about half of the tonsil. Subsequently, in the area of the lower half of the tonsil, where the carcinoma is located, work is carried out at a distance of approx. 0.5 to 1 cm, both in terms of the mucosa and the depth. Therefore, the muscles of the palatine arch were taken to the depths and the excision extended to the base of the tongue. Repeated bipolar coagulation of several vessels. At the end, a prominent vessel is stitched twice. The removed tonsil is then examined. A PE for the study is obtained from the middle of this. Otherwise, the resectate distance to the healthy person in the caudal area is relatively small at approx. 4 to 5 mm compared to the other margins. Therefore, resectate in the caudal mucosa area. Both specimens are now sent for frozen section. Subsequently, with protracted bleeding from the base of the tongue, a deep incision is also made here after multiple bipolar coagulation and continued bleeding. Subsequently dry conditions. The operation was therefore completed at this point without complications. Conclusion: cT1 tonsillar carcinoma on the left. Computed tomography cN0 neck status, sonography also cN0, but with a suspicious nodus in level II on the right that is worth checking. In addition, several thyroid nodules, some without ......... and microcalcifications, therefore nuclear medicine clarification recommended here (scintigraphy unfortunately only possible in 2 ˝ months due to the CT scan performed). Due to the suspicious nodus in level II on the opposite side, primary advice for selective neck dissection on both sides. \ No newline at end of file diff --git a/592/InvasionFront_CD3_block8_x1_y2_patient592_0.json b/592/InvasionFront_CD3_block8_x1_y2_patient592_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0ea828d4f6aee8066a2f06cd1d79d82dab4dcb34 --- /dev/null +++ b/592/InvasionFront_CD3_block8_x1_y2_patient592_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 15441.8, + "Num Detections": 27077, + "Num Negative": 19183, + "Num Positive": 7894, + "Positive %": 29.15, + "Num Positive per mm^2": 2749.8 + } +} \ No newline at end of file diff --git a/592/InvasionFront_CD3_block8_x2_y2_patient592_1.json b/592/InvasionFront_CD3_block8_x2_y2_patient592_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a12af1042a2367247d6f621f030fb7f4efc803b0 --- /dev/null +++ b/592/InvasionFront_CD3_block8_x2_y2_patient592_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 15391.9, + "Num Detections": 27962, + "Num Negative": 19423, + "Num Positive": 8539, + "Positive %": 30.54, + "Num Positive per mm^2": 3058.3 + } +} \ No newline at end of file diff --git a/592/InvasionFront_CD8_block8_x1_y2_patient592_0.json b/592/InvasionFront_CD8_block8_x1_y2_patient592_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e40509ce420e0ca7b3a4ac1cd6bd3c88c3e39674 --- /dev/null +++ b/592/InvasionFront_CD8_block8_x1_y2_patient592_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4822.4, + "Centroid Y µm": 4947.4, + "Num Detections": 28694, + "Num Negative": 23149, + "Num Positive": 5545, + "Positive %": 19.32, + "Num Positive per mm^2": 1909.9 + } +} \ No newline at end of file diff --git a/592/InvasionFront_CD8_block8_x2_y2_patient592_1.json b/592/InvasionFront_CD8_block8_x2_y2_patient592_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5fcb0028a3dbb62af83bfa737b329ce0838564da --- /dev/null +++ b/592/InvasionFront_CD8_block8_x2_y2_patient592_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7521.0, + "Centroid Y µm": 5072.3, + "Num Detections": 30041, + "Num Negative": 24890, + "Num Positive": 5151, + "Positive %": 17.15, + "Num Positive per mm^2": 1834.3 + } +} \ No newline at end of file diff --git a/592/TumorCenter_CD3_block8_x1_y2_patient592_0.json b/592/TumorCenter_CD3_block8_x1_y2_patient592_0.json new file mode 100644 index 0000000000000000000000000000000000000000..af541ddf71fe0247a92dfa40f17adcecde6ec12a --- /dev/null +++ b/592/TumorCenter_CD3_block8_x1_y2_patient592_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 7296.1, + "Num Detections": 27905, + "Num Negative": 15444, + "Num Positive": 12461, + "Positive %": 44.66, + "Num Positive per mm^2": 4345.1 + } +} \ No newline at end of file diff --git a/592/TumorCenter_CD3_block8_x2_y2_patient592_1.json b/592/TumorCenter_CD3_block8_x2_y2_patient592_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef9257ee8f3d720650a19432f466b9d845042f3a --- /dev/null +++ b/592/TumorCenter_CD3_block8_x2_y2_patient592_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.8, + "Centroid Y µm": 6871.4, + "Num Detections": 29037, + "Num Negative": 18628, + "Num Positive": 10409, + "Positive %": 35.85, + "Num Positive per mm^2": 3585.2 + } +} \ No newline at end of file diff --git a/592/TumorCenter_CD8_block8_x1_y2_patient592_0.json b/592/TumorCenter_CD8_block8_x1_y2_patient592_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bd5444dd6b14e5b87df80e66ab9590e84670c9d4 --- /dev/null +++ b/592/TumorCenter_CD8_block8_x1_y2_patient592_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 6621.5, + "Num Detections": 32784, + "Num Negative": 29397, + "Num Positive": 3387, + "Positive %": 10.33, + "Num Positive per mm^2": 1202.2 + } +} \ No newline at end of file diff --git a/592/TumorCenter_CD8_block8_x2_y2_patient592_1.json b/592/TumorCenter_CD8_block8_x2_y2_patient592_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb5593b663a2effc2f85e48b569806721b220441 --- /dev/null +++ b/592/TumorCenter_CD8_block8_x2_y2_patient592_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 6471.6, + "Num Detections": 25595, + "Num Negative": 25094, + "Num Positive": 501, + "Positive %": 1.957, + "Num Positive per mm^2": 234.6 + } +} \ No newline at end of file diff --git a/592/history_text.txt b/592/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6bace74ff55eebcecc4998686c6cda0c572920bb --- /dev/null +++ b/592/history_text.txt @@ -0,0 +1 @@ +In the patient <2013> a poorly differentiated and HPV-positive left tonsillar carcinoma was histologically confirmed. In summary of panendoscopy, CT findings and sonography cT2 cN2b G3 oropharyngeal carcinoma on the left. In our interdisciplinary tumor conference, the indication for primary surgical treatment was made. The patient was also found to have severe visual impairment due to macular degeneration. \ No newline at end of file diff --git a/592/icd_codes.txt b/592/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/592/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/592/ops_codes.txt b/592/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e5f70482b8386bd7e372bdd15cf321350ff4a251 --- /dev/null +++ b/592/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] ohne Rekonstruktion[5-296.00 ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/592/patient_clinical_data.json b/592/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5ed12e597513b73e0d2e7fbbd32fec13ec519a52 --- /dev/null +++ b/592/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 75, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/592/patient_pathological_data.json b/592/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4e9ba19d0ef178622f1ea58658b50eb78b449bfa --- /dev/null +++ b/592/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "592", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 14.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/592/surgery_description.txt b/592/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b87331c3f17de86fa0d443e78f065dfe4149fc79 --- /dev/null +++ b/592/surgery_description.txt @@ -0,0 +1 @@ +Transorale Tumorresektion, radikale Neck dissection diff --git a/592/surgery_report.txt b/592/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1ea57ae161a50a5bda51b87b3c990d97ccc532f --- /dev/null +++ b/592/surgery_report.txt @@ -0,0 +1 @@ +Initial inspection and palpation of the findings. There is an exulcerated mass in the area of the middle and cranial tonsil pole, clearly growing laterally submucosally. Here, however, it can be palpated and moved in depth. Parauvular triangle just free of tumor. No growth beyond the posterior palatal arch or beyond the caudal tonsil pole. Endoscopic PEG placement is performed first. This is done with the gastroscope under laryngoscopic control. Easy advancement into the stomach. Excellent diaphanoscopy. Problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. The stomach and oesophagus are otherwise unremarkable in the mirror findings. Now turn to transoral tumor resection. Insertion of the tonsil retractor and oral tumor resection in the sense of a radical tonsillectomy. Complete removal of the anterior palatal arch. Resection up to the parauvular level. There is a good displacement layer above the tumor in depth. Here complete in sano removal. Release of the tonsil at the transition to the base of the tongue, basally towards the posterior palatal arch, removal of muscles. No further tumor growth here. Deposition at the posterior palatal arch to the lower tonsil pole, macroscopically in sano. The specimen now only shows a small safety margin parauvularly due to shrinkage, otherwise a safety margin of at least 1.5 cm on all sides at the mucosal level. Basally, the tumor is intact, but due to the thin tissue conditions above the capsule, there is a narrow safety margin. A narrow resection is performed in the area of the soft palate and parauvularly to ensure R0 resection. The specimen and the additional marginal sample are thread-marked for frozen section diagnostics. All mucosal margins were found to be completely free of tumor and dysplasia. Only in the basal area is there a narrow R0 situation with a distance of just under 0.1 cm, but with tumor-free margins. The case and findings are now discussed with due to the narrow basal resection margin. In the case of microscopic but narrow R0 resection, a corresponding post-resection or covering margin specimens are now created. For this purpose, superficial muscle resection. Covering of the area close to the capsule, which corresponds to the lateral tonsil bed. Finally, ablation of the musculature. Only a small amount of circumscribed prolapsing fatty tissue. This is coagulated. The surrounding and tumor capsule-covering musculature is diagnosed as completely tumor-free in the frozen section diagnosis. Therefore, an R0 resection can be assumed here. Careful wound inspection. Wound surface is clearly visible and can be explored. Two adapting sutures are now placed in the area of the parauvular mucosa. Here, too, the conditions towards the back of the soft palate are intact, so that good swallowing function appears to be guaranteed. The neck dissection of the right side is now performed during the frozen section pauses. For this, a submandibular skin incision is made. Cut through the skin and subcutaneous tissue. Exposure and dissection of the platysma. Creation of a platysma flap. Exposure of the sternocleidomastoid muscle and preservation of the external jugular vein. Exposure of the omohyoid muscle, the digastric muscle and the submandibular gland. Clearing out the anterior neck preparation while carefully protecting the cervical artery, the superior thyroid artery, the facial vein and the hypoglossal nerve. Exposure of the accessorius nerve. Clearing of level V a with careful protection of the cervical plexus branches after exposure and dissection of the cervical vascular sheath. Overall, no macroscopically highly suspicious masses. Careful wound inspection and, if the wound is dry, insertion of a 10-gauge Redon drain and careful, two-layer wound closure. Turn to the opposite side. Same procedure here in principle. Sonographically there is a cN2b neck status. Corresponding incision. Cut through skin and subcutaneous tissue. Dissection of the platysma. Exposure of the sternocleidomastoid muscle, the digastric muscle and the omohyoid muscle. Release of the submandibular gland. Palpation of rough, suspicious nodes in levels II a and II b with transition to level V a. Visualization of the accessorius nerve. This is free. Clearing of the anterior neck preparation with careful preservation of the superior thyroid artery, the facial vein, the cervical vein and the hypoglossal nerve. Free preparation of the internal jugular vein. A large metastasis measuring a good 3 cm can be seen in the jugulo-facial angle. Clearing of the accessorius triangle. Highly suspicious change here as well. Sparing involvement of the surrounding musculature. At the transition to level V a, it can now be seen that a highly suspicious nodule is infiltrating the cervical plexus in a circumscribed manner, so this must be resected in a circumscribed manner. Complete release up to the transition from level V b, also complete release below the cervical plexus. Overall in level II b and V a several small but highly visible lesions due to the macroscopic changes. Careful palpation of the supraclavicular and infraclavicular region as well as paravertebrally. No further nodules here. Therefore, after careful wound inspection, irrigation with H2 and Ringer's solution. Then insertion of a 10 Redon drain and careful, two-layer wound closure. Final enoral inspection again. Multiple checks for blood dryness. Circumscribed final hemostasis. However, if the wound is dry overall and the wound cavity is clearly visible, a tracheostomy is not performed due to the high degree of visual impairment and lack of swelling. The procedure was subsequently completed without any indication of complications. The patient received intraoperative antibiotics with Unacid 3 g. Please continue this for 24 hours postoperatively. The patient should abstain from food for at least 2 to 4 days, then carefully and gradually build up her diet. Due to the cervical metastasis, adjuvant therapy appears to be urgently required. \ No newline at end of file diff --git a/593/InvasionFront_CD3_block17_x1_y12_patient593_0.json b/593/InvasionFront_CD3_block17_x1_y12_patient593_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1d55b665ca39ffd205a01a4f4ad0097529fdb755 --- /dev/null +++ b/593/InvasionFront_CD3_block17_x1_y12_patient593_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3148.3, + "Centroid Y µm": 34931.5, + "Num Detections": 22079, + "Num Negative": 20750, + "Num Positive": 1329, + "Positive %": 6.019, + "Num Positive per mm^2": 534.52 + } +} \ No newline at end of file diff --git a/593/InvasionFront_CD3_block17_x2_y12_patient593_1.json b/593/InvasionFront_CD3_block17_x2_y12_patient593_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4fa000feefe1bca46696ae4c097fd72632d3f96f --- /dev/null +++ b/593/InvasionFront_CD3_block17_x2_y12_patient593_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 34981.5, + "Num Detections": 25111, + "Num Negative": 23243, + "Num Positive": 1868, + "Positive %": 7.439, + "Num Positive per mm^2": 676.16 + } +} \ No newline at end of file diff --git a/593/InvasionFront_CD8_block17_x1_y12_patient593_0.json b/593/InvasionFront_CD8_block17_x1_y12_patient593_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b5f1c68585e713996eaf02e2cabd64fac112c9d9 --- /dev/null +++ b/593/InvasionFront_CD8_block17_x1_y12_patient593_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 29784.2, + "Num Detections": 23173, + "Num Negative": 22844, + "Num Positive": 329, + "Positive %": 1.42, + "Num Positive per mm^2": 127.78 + } +} \ No newline at end of file diff --git a/593/InvasionFront_CD8_block17_x2_y12_patient593_1.json b/593/InvasionFront_CD8_block17_x2_y12_patient593_1.json new file mode 100644 index 0000000000000000000000000000000000000000..61e330ebfc146da1f4e59e6cd7f7bbc6baa1c65c --- /dev/null +++ b/593/InvasionFront_CD8_block17_x2_y12_patient593_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 29759.2, + "Num Detections": 24783, + "Num Negative": 24108, + "Num Positive": 675, + "Positive %": 2.724, + "Num Positive per mm^2": 253.35 + } +} \ No newline at end of file diff --git a/593/TumorCenter_CD3_block17_x1_y12_patient593_0.json b/593/TumorCenter_CD3_block17_x1_y12_patient593_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5ef4424cd9d315edb6f90140d51ac22c69babc01 --- /dev/null +++ b/593/TumorCenter_CD3_block17_x1_y12_patient593_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 29434.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/593/TumorCenter_CD3_block17_x2_y12_patient593_1.json b/593/TumorCenter_CD3_block17_x2_y12_patient593_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3edf5d1071f8eb218bcaaf9ef51eb944e4827329 --- /dev/null +++ b/593/TumorCenter_CD3_block17_x2_y12_patient593_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6021.8, + "Centroid Y µm": 29484.4, + "Num Detections": 16454, + "Num Negative": 15748, + "Num Positive": 706, + "Positive %": 4.291, + "Num Positive per mm^2": 342.15 + } +} \ No newline at end of file diff --git a/593/TumorCenter_CD8_block17_x1_y12_patient593_0.json b/593/TumorCenter_CD8_block17_x1_y12_patient593_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69ca5fd2c05ac6657774ccacb21c05efa5dd3a54 --- /dev/null +++ b/593/TumorCenter_CD8_block17_x1_y12_patient593_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6552.4, + "Centroid Y µm": 43486.8, + "Num Detections": 19830, + "Num Negative": 19515, + "Num Positive": 315, + "Positive %": 1.589, + "Num Positive per mm^2": 141.11 + } +} \ No newline at end of file diff --git a/593/TumorCenter_CD8_block17_x2_y12_patient593_1.json b/593/TumorCenter_CD8_block17_x2_y12_patient593_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e91e40c9782eef849195e8a722fafaf42a4068cc --- /dev/null +++ b/593/TumorCenter_CD8_block17_x2_y12_patient593_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9095.2, + "Centroid Y µm": 43477.0, + "Num Detections": 16049, + "Num Negative": 15878, + "Num Positive": 171, + "Positive %": 1.065, + "Num Positive per mm^2": 91.4 + } +} \ No newline at end of file diff --git a/593/history_text.txt b/593/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..33c97606fd83fd3eee9b03c4cef379dfea905ee9 --- /dev/null +++ b/593/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed cT2 cN0 glottic laryngeal carcinoma, completely occupying the entire left vocal fold up to the vocal process, the arytenoid cartilage and the left morgue sinus. Thus indication for the above-mentioned measures. \ No newline at end of file diff --git a/593/icd_codes.txt b/593/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c524169f7565f12e153db0fa9bd192bc0fa146d7 --- /dev/null +++ b/593/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Larynx[D38.0 ] \ No newline at end of file diff --git a/593/ops_codes.txt b/593/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8527f43a2277140dc0d8b433d184da3915441bb9 --- /dev/null +++ b/593/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/593/patient_clinical_data.json b/593/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b5a2d88d5bfad166f14a580239bc7721cf4d13bd --- /dev/null +++ b/593/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/593/patient_pathological_data.json b/593/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..61ed6bc7efd1ab518e1417decd003858027915b4 --- /dev/null +++ b/593/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "593", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/593/surgery_description.txt b/593/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce0196059fc165860edecc35c3302c6b71d591c5 --- /dev/null +++ b/593/surgery_description.txt @@ -0,0 +1 @@ +frontolateral KK-Teilresektion, Tracheoskopie. Laryngoskopie diff --git a/593/surgery_report.txt b/593/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4f42d179528304fe0af62a385c53a8765a116ee --- /dev/null +++ b/593/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia. Perform tracheoscopy. The area of the trachea up to the carina is unremarkable. Inspection of the endolarynx. The tumor was found to be growing largely submucosally, completely occupying the entire left vocal fold and the morgue sinus. This confirmed the diagnosis of a cT2 glottic laryngeal carcinoma on the left. Skin ablation and sterile draping. Creation of an approx. 4 cm long skin incision. Cut through the subcutaneous tissue and the platysma. Formation of a subplatysmal flap cranially to the hyoid bone and caudally to the cricoid cartilage. Exposure of the anterior jugular vein with its branches. Ligation of the same. Expose the prelaryngeal muscles in the midline. Move the prelaryngeal muscles to the side on both sides. Exposure of the thyroid cartilage, the cricothyroid vein and the cricoid cartilage. First horizontal transverse incision of the ligamentum conicum. Paramedian scalpel incision on the right side of the thyroid cartilage perichondrium. Exposure of the thyroid cartilage. Subsequent right paramedian thyrotomy using a wheel. Entering the endolaryngeal lumen. Insertion of the laryngeal retractors and subsequent insertion into the correct subendochondral layer using the FREER. Due to the clear submucosal growth, the decision was made to resect a large area, taking fibers of the vocalis muscle and the thyroaryaenoid muscle with it. Inclusion of the morgue sinus in the preparation. Exposure and sparing of the left arytenoid cartilage. Then take 5 representative marginal samples (supraglottic, subglottic, anterior towards the anterior commissure, posterior towards the arytenoid cartilage and wound bed). All 5 margin samples are found to be tumor-free by the pathology colleagues during a frozen section examination. Hemostasis in the area of the wound bed using bipolar coagulation. Dry conditions. Creation of drill holes on the thyroid cartilage using a Lindemann reamer and primary closure of the thyroid cartilage using two Vicryl 3-0 sutures. Subsequent suture adaptation of the edges of the ligamentum conicum using Vicryl 4-0 sutures. Insertion of a flap. Suture adaptation of the perichondrium of the thyroid cartilage, suture adaptation of the prelaryngeal muscles in the midline. Platysma suture, subcutaneous suture, single-button skin suture, application of a pressure bandage. Completion of the procedure without complications. Please schedule a follow-up MLE in 8 weeks. \ No newline at end of file diff --git a/594/InvasionFront_CD3_block5_x3_y9_patient594_0.json b/594/InvasionFront_CD3_block5_x3_y9_patient594_0.json new file mode 100644 index 0000000000000000000000000000000000000000..edb9f1a79e8f668cf6c121186000eb0486c23623 --- /dev/null +++ b/594/InvasionFront_CD3_block5_x3_y9_patient594_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 22837.9, + "Num Detections": 20777, + "Num Negative": 20071, + "Num Positive": 706, + "Positive %": 3.398, + "Num Positive per mm^2": 336.85 + } +} \ No newline at end of file diff --git a/594/InvasionFront_CD3_block5_x4_y9_patient594_1.json b/594/InvasionFront_CD3_block5_x4_y9_patient594_1.json new file mode 100644 index 0000000000000000000000000000000000000000..82371783b2cf80a395644edd2ff913abec9e1b08 --- /dev/null +++ b/594/InvasionFront_CD3_block5_x4_y9_patient594_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 22912.9, + "Num Detections": 14341, + "Num Negative": 14257, + "Num Positive": 84, + "Positive %": 0.5857, + "Num Positive per mm^2": 48.26 + } +} \ No newline at end of file diff --git a/594/InvasionFront_CD8_block5_x3_y7_patient594_0.json b/594/InvasionFront_CD8_block5_x3_y7_patient594_0.json new file mode 100644 index 0000000000000000000000000000000000000000..361fe32424584c9ab605d370490c0e3d6f391d26 --- /dev/null +++ b/594/InvasionFront_CD8_block5_x3_y7_patient594_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 17740.6, + "Num Detections": 17277, + "Num Negative": 16884, + "Num Positive": 393, + "Positive %": 2.275, + "Num Positive per mm^2": 207.12 + } +} \ No newline at end of file diff --git a/594/InvasionFront_CD8_block5_x4_y7_patient594_1.json b/594/InvasionFront_CD8_block5_x4_y7_patient594_1.json new file mode 100644 index 0000000000000000000000000000000000000000..687de59ee21fdd6d70b548f04df67dd80e7985ac --- /dev/null +++ b/594/InvasionFront_CD8_block5_x4_y7_patient594_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 17865.5, + "Num Detections": 28158, + "Num Negative": 24497, + "Num Positive": 3661, + "Positive %": 13.0, + "Num Positive per mm^2": 1525.9 + } +} \ No newline at end of file diff --git a/594/TumorCenter_CD3_block5_x3_y7_patient594_0.json b/594/TumorCenter_CD3_block5_x3_y7_patient594_0.json new file mode 100644 index 0000000000000000000000000000000000000000..58ede6e81385842510556c98c7eca387b8e6dbe0 --- /dev/null +++ b/594/TumorCenter_CD3_block5_x3_y7_patient594_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11693.8, + "Centroid Y µm": 17415.8, + "Num Detections": 19211, + "Num Negative": 18255, + "Num Positive": 956, + "Positive %": 4.976, + "Num Positive per mm^2": 395.34 + } +} \ No newline at end of file diff --git a/594/TumorCenter_CD3_block5_x4_y7_patient594_1.json b/594/TumorCenter_CD3_block5_x4_y7_patient594_1.json new file mode 100644 index 0000000000000000000000000000000000000000..30bc9b81497f7109a581d49c8b840660f9bd15b3 --- /dev/null +++ b/594/TumorCenter_CD3_block5_x4_y7_patient594_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14442.4, + "Centroid Y µm": 17590.7, + "Num Detections": 15630, + "Num Negative": 15138, + "Num Positive": 492, + "Positive %": 3.148, + "Num Positive per mm^2": 263.95 + } +} \ No newline at end of file diff --git a/594/TumorCenter_CD8_block5_x3_y7_patient594_0.json b/594/TumorCenter_CD8_block5_x3_y7_patient594_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee821293d6017b1465d951352de776e4d5be2abd --- /dev/null +++ b/594/TumorCenter_CD8_block5_x3_y7_patient594_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 17590.7, + "Num Detections": 19707, + "Num Negative": 18821, + "Num Positive": 886, + "Positive %": 4.496, + "Num Positive per mm^2": 368.0 + } +} \ No newline at end of file diff --git a/594/TumorCenter_CD8_block5_x4_y7_patient594_1.json b/594/TumorCenter_CD8_block5_x4_y7_patient594_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7a0c1db03d5675d7a940dbd4aa404c84d3b4c2d7 --- /dev/null +++ b/594/TumorCenter_CD8_block5_x4_y7_patient594_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 17590.7, + "Num Detections": 18558, + "Num Negative": 18163, + "Num Positive": 395, + "Positive %": 2.128, + "Num Positive per mm^2": 171.68 + } +} \ No newline at end of file diff --git a/594/history_text.txt b/594/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/594/icd_codes.txt b/594/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/594/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/594/ops_codes.txt b/594/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c048d1337d40812f9c5ac68f7af95532a955d63e --- /dev/null +++ b/594/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Transorale Tumortonsillektomie[5-281.2 ] Temporäre Tracheotomie[5-311.0 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit gestieltem regionalen Lappen[5-295.02 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Gefäßgestielte Faszienlappenplastik am Unterarm[5-857.53 L] Spalthaut großflächig Empfängerstelle sonstige[5-902.4x R] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/594/patient_clinical_data.json b/594/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5f0c78d16e77f84b8f25d641d4dd78b0d338c3ca --- /dev/null +++ b/594/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 61, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/594/patient_pathological_data.json b/594/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..18f6eba24f939bba7cc354e94e5e46c2cfb826aa --- /dev/null +++ b/594/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "594", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/594/surgery_description.txt b/594/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed3eabce7788621ac9460a80cc8aa41707371fd9 --- /dev/null +++ b/594/surgery_description.txt @@ -0,0 +1 @@ +Resektion, Neck diss. bds., Tracheotomie, PEG-Anlage, Defektdeckung, Freier Lappen (Radialis) diff --git a/594/surgery_report.txt b/594/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..42e03569250481316ff2262d686debd3ca32abca --- /dev/null +++ b/594/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues, then first performing the tracheotomy by and : 2 cm horizontal skin incision just below the cricoid cartilage, 2 QF above the jugulum and cutting through the cutaneous-subcutaneous tissue. Ligation of superficial veins, division of the musculature in the vertical line and pushing the musculature to the side. Pointed dissection of the cricoid cartilage. Identification of the thyroid isthmus. Blunt undermining of the thyroid isthmus and ligation of the same. Freeing the trachea. Identification of the 2nd and 3rd tracheal rings. Insertion between the 2nd and 3rd tracheal ring and creation of a visceral tracheotomy in the usual manner. Suturing of the tracheal cartilage to the skin to create an epithelialized tracheostoma. This is done without complications. Placement of an 8 mm tracheal cannula. Then repositioning of the patient and sterile washing and draping. Insertion of the Mc Ivor mouth blocker and inspection of the site. A rather flat, exophytic mass was found in the area of the posterior palatal arch and the posterior pharyngeal wall as well as partially in the tonsil on the right side. Start of tumor resection with the monopolar needle. It soon becomes apparent that the tumor has deeper parts. Then dissection in depth. Here, massive venous bleeding suddenly occurs. This can no longer be controlled by transoral measures. Therefore, the oropharynx is tamponaded and the neck is opened on the right side. Exposure of the cervical vascular sheath. Identification of the external carotid artery. Then temporary clamping of the external carotid artery with a reinforced bulldog, nevertheless further bleeding, then further dissection of the cervical vascular sheath. Here it can be seen that a large outlet from the internal jugular vein has opened very high up and is bleeding gushingly into the oropharynx. This outlet is carefully clamped and clipped several times. Immediate hemostasis and now further dissection of the neck and performance of the remaining tumor resection from the transcervical side. The specimen is placed on cork and sent directly to the frozen section. In the frozen section, all edges are free of tumor and carcinoma in situ until medium-grade dysplasia in the cranial area, which is then resected again later and the specimen sent for final histology. Then further surgery in the neck on the right side and start with the neck dissection. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid of the submandibular gland and the digastric muscle. Then removal of the neck specimens IIa to Va while sparing the plexus branches and sparing the hypoglossal nerve and accessorius nerve. Dissection of the neck vessels. It can be seen that there are only very slender vessels here, both venous and arterial, and that this side is also not suitable for connecting the radialis graft. On the left side, neck dissection through and , exposing the sternocleidomastoid muscle, exposing the submandibular gland, the omohyoid and the digastric muscle. Then expose the cervical vascular sheath, the hypoglossus and the accessorius nerve and remove the neck preparation IIa to Va while sparing the plexus branches. Dissection of the vessels. This also shows a very, very thin superior thyroid artery and the facial artery is also unsuitable for connection of an anastomosis; the venous situation is significantly better than on the right side. There is a very thick facial artery with an outlet, which is perfectly possible for venous connection. For the arterial connection, the external carotid artery itself is prepared in the cranial region above the exit of the superior facial and lingual thyroid arteries and also above the ascending pharyngeal artery, then cut downwards. In the meantime, the radial artery graft is lifted in bloodlessness by and : Palpatory identification of the distal radial artery. Marking of the flap borders (7 x 9 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. At the beginning of the operation, a PEG was placed with good diaphanoscopy using the thread pull-through method. Continue antibiotics. The patient can wake up postoperatively, but should continue to be monitored in the intensive care unit. Block attempt without an X-ray pre-swallow on the 10th postoperative day. \ No newline at end of file diff --git a/595/InvasionFront_CD3_block17_x5_y1_patient595_0.json b/595/InvasionFront_CD3_block17_x5_y1_patient595_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e60f32ab1188690f0fbcaf724b0b18fb7e6caf8 --- /dev/null +++ b/595/InvasionFront_CD3_block17_x5_y1_patient595_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 7571.0, + "Num Detections": 20348, + "Num Negative": 18683, + "Num Positive": 1665, + "Positive %": 8.183, + "Num Positive per mm^2": 625.46 + } +} \ No newline at end of file diff --git a/595/InvasionFront_CD3_block17_x6_y1_patient595_1.json b/595/InvasionFront_CD3_block17_x6_y1_patient595_1.json new file mode 100644 index 0000000000000000000000000000000000000000..43e940ac0c57841c0d5067a7190b8b58002814ed --- /dev/null +++ b/595/InvasionFront_CD3_block17_x6_y1_patient595_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 7546.0, + "Num Detections": 22408, + "Num Negative": 19959, + "Num Positive": 2449, + "Positive %": 10.93, + "Num Positive per mm^2": 964.84 + } +} \ No newline at end of file diff --git a/595/InvasionFront_CD8_block17_x5_y1_patient595_0.json b/595/InvasionFront_CD8_block17_x5_y1_patient595_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65ab733adee14a34f89b0a39e8fb58963f04b612 --- /dev/null +++ b/595/InvasionFront_CD8_block17_x5_y1_patient595_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 2773.5, + "Num Detections": 21189, + "Num Negative": 20441, + "Num Positive": 748, + "Positive %": 3.53, + "Num Positive per mm^2": 295.24 + } +} \ No newline at end of file diff --git a/595/InvasionFront_CD8_block17_x6_y1_patient595_1.json b/595/InvasionFront_CD8_block17_x6_y1_patient595_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c46aae32ea403c57dde13410e51aff3f2ca7f18 --- /dev/null +++ b/595/InvasionFront_CD8_block17_x6_y1_patient595_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 2798.5, + "Num Detections": 21122, + "Num Negative": 19568, + "Num Positive": 1554, + "Positive %": 7.357, + "Num Positive per mm^2": 643.41 + } +} \ No newline at end of file diff --git a/595/TumorCenter_CD3_block17_x5_y1_patient595_0.json b/595/TumorCenter_CD3_block17_x5_y1_patient595_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9db6c0fd23daadc29a2347d939dde501c986e9be --- /dev/null +++ b/595/TumorCenter_CD3_block17_x5_y1_patient595_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 2548.7, + "Num Detections": 23947, + "Num Negative": 20917, + "Num Positive": 3030, + "Positive %": 12.65, + "Num Positive per mm^2": 1127.0 + } +} \ No newline at end of file diff --git a/595/TumorCenter_CD3_block17_x6_y1_patient595_1.json b/595/TumorCenter_CD3_block17_x6_y1_patient595_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e68e9b0d61473f156d6a4a04cfe407091ebfbe9 --- /dev/null +++ b/595/TumorCenter_CD3_block17_x6_y1_patient595_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 2548.7, + "Num Detections": 25813, + "Num Negative": 21920, + "Num Positive": 3893, + "Positive %": 15.08, + "Num Positive per mm^2": 1412.7 + } +} \ No newline at end of file diff --git a/595/TumorCenter_CD8_block17_x5_y1_patient595_0.json b/595/TumorCenter_CD8_block17_x5_y1_patient595_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2d406ba151b01900c93376ca2c14b988868e3e6f --- /dev/null +++ b/595/TumorCenter_CD8_block17_x5_y1_patient595_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 16016.5, + "Num Detections": 23581, + "Num Negative": 21908, + "Num Positive": 1673, + "Positive %": 7.095, + "Num Positive per mm^2": 638.63 + } +} \ No newline at end of file diff --git a/595/TumorCenter_CD8_block17_x6_y1_patient595_1.json b/595/TumorCenter_CD8_block17_x6_y1_patient595_1.json new file mode 100644 index 0000000000000000000000000000000000000000..254f31327cd17cab9cc25ab43296309a9f3a71c7 --- /dev/null +++ b/595/TumorCenter_CD8_block17_x6_y1_patient595_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21213.8, + "Centroid Y µm": 15991.5, + "Num Detections": 26066, + "Num Negative": 23940, + "Num Positive": 2126, + "Positive %": 8.156, + "Num Positive per mm^2": 785.39 + } +} \ No newline at end of file diff --git a/595/history_text.txt b/595/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/595/icd_codes.txt b/595/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/595/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/595/ops_codes.txt b/595/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bfbe8e29962f52130cc977af5031f2541301f064 --- /dev/null +++ b/595/ops_codes.txt @@ -0,0 +1 @@ +Chordektomie durch Thyreotomie[5-302.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/595/patient_clinical_data.json b/595/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a2e374ad54f3d895ca175e786a384a8f3877e3a1 --- /dev/null +++ b/595/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/595/patient_pathological_data.json b/595/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..08b6214be88e11611deb55f8993f53dee9a21f52 --- /dev/null +++ b/595/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "595", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/595/surgery_description.txt b/595/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..20d81ec7fa05c63506a54f9b4c65fa8309a8256d --- /dev/null +++ b/595/surgery_description.txt @@ -0,0 +1 @@ +Externe Chordektomie diff --git a/595/surgery_report.txt b/595/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ef34559ba739065ce8445ef047a82f2d801d453 --- /dev/null +++ b/595/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, first disinfect the skin. First of all, the endolarynx is adjusted again with the Kleinsasser C-tube. Here you can see an exophytic mass limited to the right vocal fold with insufficient adjustability. Removal of the instruments without tooth damage. Now transition to surgery from the outside. Vertical serrated skin incision and sharp dissection through the subcutis down to the straight neck muscles. This is pushed apart in the linea alba and held to the side. Then skeletonize the thyroid cartilage including the cricoid cartilage. Incision of the perichondrium on the outer side cranially and caudally so that a right pedicled perichondrium flap can be dissected. Subperichondrial dissection is then performed cranially and caudally in the area of the anterior incisure of the thyroid cartilage. The thyroid cartilage is then cut open in the middle with the small circular saw blade and held apart. The soft tissues in the median plane can then also be pushed apart or cut sharply so that the larynx can be opened up. Here you can now see the tumor on the right side, which extends into the anterior commissure. The mucosa here is somewhat raised and uneven due to the previous dissection. Now begin with the resection, initially cranially in the area of the supraglottis on the right side. Part of the vocal fold slope must also be resected caudally, as it is also affected by tumor in the anterior part. Large parts of the vocalis muscle are resected basally. Resection is performed dorsally, following the tumor margins at an appropriate distance. The arytenoid cartilage is reached and the ventral part of the arytenoid cartilage must also be resected due to the extent of the tumor. Circumferential marginal incisions are then made, particularly in the area of the anterior commissure, which also includes the opposite side. The marginal incisions all proved to be tumor-free. Only in the area of the arytenoid cartilage are there still punctiform infiltrates. Extensive resection is therefore performed here. The further marginal incision from this area is then also tumor-free. The drill holes are then made to reunite the thyroid cartilage after it has been smoothed endolaryngeally in the area of the incision using the Lindemann burr. Placement of a rein suture on the left vocal fold ventrally. Reconstruction of the thyroid cartilage as well as the cricothyroid membrane using several sutures. Folding back of the perichondrium flap. Application of fibrin glue, which was also previously applied to the resection area. Application of a Tachosil plate to the thyroid cartilage. Insertion of a drainage flap under the sutured straight neck muscles. Final two-layer wound closure. Sterile wound dressing. Finally, another inspection of the endolarynx transorally. Aspiration of a small amount of secretion with inconspicuous and dry wound conditions. End of the operation and handover of the patient to anesthesia. Conclusion: External partial laryngectomy in the sense of an external chordectomy on the right side for cT1a laryngeal carcinoma with spread to the arytenoid cartilage on the right. Control panendoscopy in 8 weeks. \ No newline at end of file diff --git a/596/InvasionFront_CD3_block20_x1_y2_patient596_0.json b/596/InvasionFront_CD3_block20_x1_y2_patient596_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2a412cb816a0827d097ea9add27ea099a39f4d43 --- /dev/null +++ b/596/InvasionFront_CD3_block20_x1_y2_patient596_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5464.7, + "Centroid Y µm": 5699.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/596/InvasionFront_CD3_block20_x2_y2_patient596_1.json b/596/InvasionFront_CD3_block20_x2_y2_patient596_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0f9fed6a6e5f4d277c860116ebbb2db3d3cf8f53 --- /dev/null +++ b/596/InvasionFront_CD3_block20_x2_y2_patient596_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8064.2, + "Centroid Y µm": 5167.4, + "Num Detections": 16769, + "Num Negative": 16562, + "Num Positive": 207, + "Positive %": 1.234, + "Num Positive per mm^2": 122.01 + } +} \ No newline at end of file diff --git a/596/InvasionFront_CD8_block20_x1_y2_patient596_0.json b/596/InvasionFront_CD8_block20_x1_y2_patient596_0.json new file mode 100644 index 0000000000000000000000000000000000000000..db69aa63bf68243daa6e39f176ddf5c092e25fc4 --- /dev/null +++ b/596/InvasionFront_CD8_block20_x1_y2_patient596_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3431.4, + "Centroid Y µm": 5739.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/596/InvasionFront_CD8_block20_x2_y2_patient596_1.json b/596/InvasionFront_CD8_block20_x2_y2_patient596_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ed144653ce82437cdc6538c4421e7eae487a5a0a --- /dev/null +++ b/596/InvasionFront_CD8_block20_x2_y2_patient596_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.7, + "Centroid Y µm": 5399.3, + "Num Detections": 17092, + "Num Negative": 16722, + "Num Positive": 370, + "Positive %": 2.165, + "Num Positive per mm^2": 209.16 + } +} \ No newline at end of file diff --git a/596/TumorCenter_CD3_block20_x1_y2_patient596_0.json b/596/TumorCenter_CD3_block20_x1_y2_patient596_0.json new file mode 100644 index 0000000000000000000000000000000000000000..936dfb186abd895b0fcbe2eeb9291f3b3473dfa2 --- /dev/null +++ b/596/TumorCenter_CD3_block20_x1_y2_patient596_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4005.4, + "Centroid Y µm": 4552.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/596/TumorCenter_CD3_block20_x2_y2_patient596_1.json b/596/TumorCenter_CD3_block20_x2_y2_patient596_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2db1a966a6484d2bbf5e93b1bed48fd4e7d00008 --- /dev/null +++ b/596/TumorCenter_CD3_block20_x2_y2_patient596_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6936.7, + "Centroid Y µm": 4993.9, + "Num Detections": 4544, + "Num Negative": 4531, + "Num Positive": 13, + "Positive %": 0.2861, + "Num Positive per mm^2": 25.61 + } +} \ No newline at end of file diff --git a/596/TumorCenter_CD8_block20_x1_y2_patient596_0.json b/596/TumorCenter_CD8_block20_x1_y2_patient596_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad62e67fa16e202d6981974fe4c1dd8c262f53af --- /dev/null +++ b/596/TumorCenter_CD8_block20_x1_y2_patient596_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3173.3, + "Centroid Y µm": 5322.2, + "Num Detections": 2755, + "Num Negative": 2675, + "Num Positive": 80, + "Positive %": 2.904, + "Num Positive per mm^2": 232.05 + } +} \ No newline at end of file diff --git a/596/TumorCenter_CD8_block20_x2_y2_patient596_1.json b/596/TumorCenter_CD8_block20_x2_y2_patient596_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5863ba330f763d1079342b5ee3e4072ef4916e87 --- /dev/null +++ b/596/TumorCenter_CD8_block20_x2_y2_patient596_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 5322.2, + "Num Detections": 7561, + "Num Negative": 7247, + "Num Positive": 314, + "Positive %": 4.153, + "Num Positive per mm^2": 373.36 + } +} \ No newline at end of file diff --git a/596/history_text.txt b/596/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..68f95c818143a1bf935afcb1739a755965192a5b --- /dev/null +++ b/596/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT3 cN2b G3 supraglottic laryngeal carcinoma on the left was histologically confirmed during a panendoscopy <2015>. Immediately preoperatively, there was a cN2c neck status sonographically. There was a clear internal cardiologic comorbidity. In our interdisciplinary tumor conference, the primary surgical procedure with laryngectomy was discussed as an alternative to primary RCT. After detailed preoperative discussions, the decision was made to proceed with surgery. \ No newline at end of file diff --git a/596/icd_codes.txt b/596/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/596/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/596/ops_codes.txt b/596/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cab8e2086ad977ebde77c2408cb37bad8fbd907e --- /dev/null +++ b/596/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/596/patient_clinical_data.json b/596/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..50368bbc934e56f66c9d4f716b47c3d7253cfea5 --- /dev/null +++ b/596/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 48, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/596/patient_pathological_data.json b/596/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce4a381dbecc82e29970d2a246fc5348b6756b18 --- /dev/null +++ b/596/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "596", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 7.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/596/surgery_description.txt b/596/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d13315767f01f3c671e108266fd3ddb0ff3d380 --- /dev/null +++ b/596/surgery_description.txt @@ -0,0 +1 @@ +Tumorresektion, ND bds, PEG-Anlage diff --git a/596/surgery_report.txt b/596/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..02c83b51eed8a81222c63d5ec36d59dfd111e937 --- /dev/null +++ b/596/surgery_report.txt @@ -0,0 +1 @@ +Dictation : After induction and intubation by the anesthesia colleagues, the primary tumor is inspected again. This is done with the Kleinsasser tube under dental protection. Inspection of the inconspicuous oral cavity and the oral vestibule. The exophytic tumor begins in the area of the pharyngoepiglottic fold on the left side of the oropharynx. This moves via the pharyngoepiglottic fold to the epiglottis, clearly infiltrates this on the left side and grows here via the aryepiglottic fold towards the ary and also infiltrates this on the left side. In addition, growth into the left piriform sinus, which is tumorously displaced at least in the entrance area. The glottic level as well as the esophageal entrance and the right side are completely tumor-free. The PEG tube was therefore initially inserted. Insertion with the esophagoscope under laryngoscopic control. Easy advancement into the stomach. Excellent diaphanoscopy. Problem-free puncture of the stomach and subsequent insertion of the PEG tube using the usual thread pull-through method. Repositioning of the patient. Marking and preparation of a broad-based apron flap. Subplatysmal preparation and suturing of the flap for neck dissection of the left side. Exposure of the sternocleidomastoid muscle. Dissection and preservation of the external jugular vein. Exposure and dissection of the omohyoid muscle. Release of the submandibular gland and exposure of the digastric muscle. Level II shows an extensive lymph node conglomerate, clinically clearly corresponding to metastases, and also clinically clear metastasis on palpation in level IV at the transition to V lateral to the internal jugular vein. Release of the anterior neck preparation. The facial vein is infiltrated and is deposited at the jugular vein after ligation. Exposure and preservation of the cervical vein and hypoglossal nerve as well as the superior thyroid artery. Free dissection of the internal jugular vein, common carotid artery and vagus nerve. These can be dissected freely upwards. The internal jugular vein is reduced due to the ambient pressure in the lumen, but is clearly not infiltrated. Overall, highly volnerable metastases on dissection of the accessorius nerve. After exclusion of infiltration, vulnerable mass, but absolute in-sano resection in handling. Clearing and completion of the accessorius triangle and completion towards level V with careful protection of the cervical plexus branches. No evidence of lymph leakage caudally. Here, lateral to the vein, as already described above, also vulnerable and clinically suspicious lesion, which is removed dead. Subsequent left-sided dissection of the infrahyoid musculature and release of the pharyngeal tube on the prevertebral fascia. Dictation : Neck dissection on the right. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the accessorius nerve. Then exposure of the cervical vascular sheath. Free preparation of the internal jugular vein and the facial nerve. Exposure of the hypoglossal nerve and the digastric muscle. Dissection of the neck preparation II a to V a, sparing the plexus branches. Exposure of the hyoid bone on the right side. This is not done on the left side, as the tumor may already be breaking through the soft tissues of the neck. Detachment of the oblique laryngeal muscles. Release of the piriform sinus. Careful release of the piriform sinus on the left side. This is only possible to a very limited extent so as not to cut into the tumor. Enter the pharynx just below the hyoid bone on the right side. Now you reach the posterior surface of the epiglottis. At the edge of the epiglottis, incise into the pharynx, extending the incision dorsally along the edge of the epiglottis. Inspection of the inside of the pharynx and the tumor region. Here it becomes clear that the tumor does not infiltrate the posterior pharyngeal wall, but only the lateral pharyngeal wall and the piriform sinus on the left side as well as the aryepiglottic fold and the pharyngoepiglottic fold and the arytenoid cartilage on the left side and the left side of the larynx. Now incise the mucosa along the edge of the epiglottis on the right side. Then incise along the right arytenoid cartilage and the postcricoid region. Release the piriform sinus completely and turn the larynx over to the left side. Release of the mucosa at the base of the tongue. Excision of the tumor borders with a safety margin of 1.5 cm. Finally, detachment and removal of the larynx below the cricoid cartilage. Before this, the trachea was opened and reintubation performed. Now take marginal samples from the esophageal entrance, pharyngeal side wall and base of tongue. All marginal samples go to the frozen section. Here R0 on all sides. The creation of a provox is dispensed with due to the patient's wishes. Now reduction of the insertion of the sternocleidomastoid muscle on both sides. Suture the pharynx in the usual three-layered manner. The pharyngeal suture must be performed with particular care in the area of the base of the tongue, as quite a lot of mucosa was resected here, but there is still sufficient mucosa to close the pharynx without tension. Before the pharyngeal suture, an esophageal myotomy was performed in the upper sphincter. Incision of the tracheostoma and two-layer wound closure after placement of two Redon drainage tubes. Continue antibiotics for 24 hours. Rötgenbreischluck on the 10th postoperative day, then diet build-up. \ No newline at end of file diff --git a/597/InvasionFront_CD3_block2_x5_y9_patient597_0.json b/597/InvasionFront_CD3_block2_x5_y9_patient597_0.json new file mode 100644 index 0000000000000000000000000000000000000000..93bf33ddb2b04fe96c4dd84423ddabc85e99e094 --- /dev/null +++ b/597/InvasionFront_CD3_block2_x5_y9_patient597_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 36030.9, + "Num Detections": 23109, + "Num Negative": 18517, + "Num Positive": 4592, + "Positive %": 19.87, + "Num Positive per mm^2": 1815.8 + } +} \ No newline at end of file diff --git a/597/InvasionFront_CD3_block2_x6_y9_patient597_1.json b/597/InvasionFront_CD3_block2_x6_y9_patient597_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5b35f8a9b7d768f6563a4981d5a808d7096b6309 --- /dev/null +++ b/597/InvasionFront_CD3_block2_x6_y9_patient597_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21138.8, + "Centroid Y µm": 36055.9, + "Num Detections": 28999, + "Num Negative": 25868, + "Num Positive": 3131, + "Positive %": 10.8, + "Num Positive per mm^2": 1171.7 + } +} \ No newline at end of file diff --git a/597/InvasionFront_CD8_block2_x5_y9_patient597_0.json b/597/InvasionFront_CD8_block2_x5_y9_patient597_0.json new file mode 100644 index 0000000000000000000000000000000000000000..549347fe6ebc672c3f3acc78b7546be1b06d643c --- /dev/null +++ b/597/InvasionFront_CD8_block2_x5_y9_patient597_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17240.9, + "Centroid Y µm": 23737.4, + "Num Detections": 22808, + "Num Negative": 14972, + "Num Positive": 7836, + "Positive %": 34.36, + "Num Positive per mm^2": 3201.8 + } +} \ No newline at end of file diff --git a/597/InvasionFront_CD8_block2_x6_y9_patient597_1.json b/597/InvasionFront_CD8_block2_x6_y9_patient597_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc959d1a28323645998aab75370a3b570af05ccd --- /dev/null +++ b/597/InvasionFront_CD8_block2_x6_y9_patient597_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19814.5, + "Centroid Y µm": 23837.4, + "Num Detections": 28760, + "Num Negative": 23799, + "Num Positive": 4961, + "Positive %": 17.25, + "Num Positive per mm^2": 1892.2 + } +} \ No newline at end of file diff --git a/597/TumorCenter_CD3_block2_x5_y9_patient597_0.json b/597/TumorCenter_CD3_block2_x5_y9_patient597_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4151c6d358b528047f6649a0e9dc6625c63fc02c --- /dev/null +++ b/597/TumorCenter_CD3_block2_x5_y9_patient597_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 22213.2, + "Num Detections": 24923, + "Num Negative": 19976, + "Num Positive": 4947, + "Positive %": 19.85, + "Num Positive per mm^2": 1956.0 + } +} \ No newline at end of file diff --git a/597/TumorCenter_CD3_block2_x6_y9_patient597_1.json b/597/TumorCenter_CD3_block2_x6_y9_patient597_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a8574f3fc2b5657c36397ca8e442394622022c2b --- /dev/null +++ b/597/TumorCenter_CD3_block2_x6_y9_patient597_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18515.2, + "Centroid Y µm": 22388.1, + "Num Detections": 22473, + "Num Negative": 13771, + "Num Positive": 8702, + "Positive %": 38.72, + "Num Positive per mm^2": 3481.8 + } +} \ No newline at end of file diff --git a/597/TumorCenter_CD8_block2_x5_y9_patient597_0.json b/597/TumorCenter_CD8_block2_x5_y9_patient597_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f3f17ff66f61f1f4ce829c4e02a8cf5ae086044c --- /dev/null +++ b/597/TumorCenter_CD8_block2_x5_y9_patient597_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18165.4, + "Centroid Y µm": 21988.4, + "Num Detections": 29015, + "Num Negative": 26936, + "Num Positive": 2079, + "Positive %": 7.165, + "Num Positive per mm^2": 827.87 + } +} \ No newline at end of file diff --git a/597/TumorCenter_CD8_block2_x6_y9_patient597_1.json b/597/TumorCenter_CD8_block2_x6_y9_patient597_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49e2837b04461809a1b9ebf85f1866feb200b41a --- /dev/null +++ b/597/TumorCenter_CD8_block2_x6_y9_patient597_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20689.0, + "Centroid Y µm": 21988.4, + "Num Detections": 26728, + "Num Negative": 23892, + "Num Positive": 2836, + "Positive %": 10.61, + "Num Positive per mm^2": 1116.8 + } +} \ No newline at end of file diff --git a/597/history_text.txt b/597/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/597/icd_codes.txt b/597/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa6097eacf18ae8aea8260bca82cce6b0a31ad0c --- /dev/null +++ b/597/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/597/ops_codes.txt b/597/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f41f84798060a06e90090080bd22711e13102c84 --- /dev/null +++ b/597/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Weichgaumenteilresektion[5-272.1 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Anwendung Operation-Roboter - Zusatzcode[5-987 ] \ No newline at end of file diff --git a/597/patient_clinical_data.json b/597/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c53a55ad89b753767f4818298a740102d0042b1c --- /dev/null +++ b/597/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 44, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/597/patient_pathological_data.json b/597/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..38bb848051d32534d6e8226a523af3e1066efd55 --- /dev/null +++ b/597/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "597", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 7.0, + "number_of_resected_lymph_nodes": 55, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/597/surgery_description.txt b/597/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c86edde93ea16af5112ae92bbbdf0f1881d787b1 --- /dev/null +++ b/597/surgery_description.txt @@ -0,0 +1 @@ +Transorale roboterassistierte Tumortonsillektomie links diff --git a/597/surgery_report.txt b/597/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..015177ddb7090ac9dcafc70927a08260f52d8eb0 --- /dev/null +++ b/597/surgery_report.txt @@ -0,0 +1 @@ +First, the patient is prepared and transported to the central OR of the surgical department. Induction of anesthesia and intubation by the anesthesia colleagues. Positioning of the head and insertion of spandex and dental protection. Attachment of the tongue. Insertion of the blocker. This is somewhat difficult until the tumor region is well exposed. Inserting the robotic arms into the DaVinci device and positioning the arms and the camera in the mouth area. It can be seen that the tumor completely occupies the upper pole of the tonsil on the left side and is in contact with the anterior and posterior palatal arch. In depth, the tumor extends relatively far laterally. Now grasp the anterior palatal arch and begin with the tumor resection. In the course of the tumor resection, it is confirmed that the tumor extends very far to the lateral pharyngeal wall, so that it must be resected including the muscles in this area. Now complete the resection caudally to the base of the tongue and medially to the area of the posterior palatal arch. A minimal margin may remain from the posterior palatal arch. The specimen can be retrieved in toto and also removed macroscopically in healthy tissue. Neck fat tissue is exposed on the lateral pharyngeal wall and a clear pulsation can be seen underneath. Now take marginal samples from the depths of the caudal anterior and posterior palatal arch. The marginal samples go to the frozen section. R0 situation in the frozen section. The tumor specimen is sent for final histology. Hemostasis during tumor resection using monopolar coagulation. Due to the pharyngeal defect and the pulsating carotid artery lying very close underneath, neck dissection in the primary procedure must be omitted in this case. Finally, placement of a nasogastric feeding tube. The patient goes to the ENT intensive care unit for monitoring. Please feed via the nasogastric tube for 8 days and plan a secondary neck dissection on both sides. Then presentation at the tumor conference. \ No newline at end of file diff --git a/598/InvasionFront_CD3_block7_x3_y2_patient598_0.json b/598/InvasionFront_CD3_block7_x3_y2_patient598_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1954e73c13634d6e8caf168e31a95df54cc43d46 --- /dev/null +++ b/598/InvasionFront_CD3_block7_x3_y2_patient598_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11514.8, + "Centroid Y µm": 4741.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/InvasionFront_CD3_block7_x4_y2_patient598_1.json b/598/InvasionFront_CD3_block7_x4_y2_patient598_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5bcc004eb22040f8f189225f13ca9a624c76e70c --- /dev/null +++ b/598/InvasionFront_CD3_block7_x4_y2_patient598_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14315.3, + "Centroid Y µm": 4606.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/InvasionFront_CD8_block7_x3_y2_patient598_0.json b/598/InvasionFront_CD8_block7_x3_y2_patient598_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2e5b05cfd85876861bc1401a8b4b0f5e657a89d2 --- /dev/null +++ b/598/InvasionFront_CD8_block7_x3_y2_patient598_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13443.6, + "Centroid Y µm": 5459.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/InvasionFront_CD8_block7_x4_y2_patient598_1.json b/598/InvasionFront_CD8_block7_x4_y2_patient598_1.json new file mode 100644 index 0000000000000000000000000000000000000000..64c0adb4c1d89f087668f86718cf7f2923c36a2c --- /dev/null +++ b/598/InvasionFront_CD8_block7_x4_y2_patient598_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16212.7, + "Centroid Y µm": 5687.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/TumorCenter_CD3_block7_x3_y2_patient598_0.json b/598/TumorCenter_CD3_block7_x3_y2_patient598_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4ec18be23f2ff7126d9b5d899f0ab3e5ab361c64 --- /dev/null +++ b/598/TumorCenter_CD3_block7_x3_y2_patient598_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 5122.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/TumorCenter_CD3_block7_x4_y2_patient598_1.json b/598/TumorCenter_CD3_block7_x4_y2_patient598_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8e8962c8ada0168a2fc7d943d6907ed3defc7e2d --- /dev/null +++ b/598/TumorCenter_CD3_block7_x4_y2_patient598_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 5172.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/TumorCenter_CD8_block7_x3_y2_patient598_0.json b/598/TumorCenter_CD8_block7_x3_y2_patient598_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5391a27c2070e05dfaa521ca5fba9cb22f9c7372 --- /dev/null +++ b/598/TumorCenter_CD8_block7_x3_y2_patient598_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 5497.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/TumorCenter_CD8_block7_x4_y2_patient598_1.json b/598/TumorCenter_CD8_block7_x4_y2_patient598_1.json new file mode 100644 index 0000000000000000000000000000000000000000..80f61f1690e9ddb7c702151cc578a690c19b6d43 --- /dev/null +++ b/598/TumorCenter_CD8_block7_x4_y2_patient598_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 5547.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/598/history_text.txt b/598/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a906e78e84fcfc7bfc7e85a23446a1fccce25293 --- /dev/null +++ b/598/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oropharyngeal carcinoma on the left. Growth through the pharyngeal wall on CT, therefore resection with flap coverage indicated. \ No newline at end of file diff --git a/598/icd_codes.txt b/598/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ea7b5ab91eeeaa74c1a439da76872badce95415 --- /dev/null +++ b/598/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] Halslymphknotenmetastasen[C77.0 L] \ No newline at end of file diff --git a/598/ops_codes.txt b/598/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4abddcff62fa1b458ae9dba993db7c18ec49c3f --- /dev/null +++ b/598/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Sonstige perkutan-endoskopisch Gastrostomie (PEG)[5-431.2x ] Temporäre Tracheotomie[5-311.0 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Großflächige freie Spalthauttransplantation auf granulierendes Hautareal am Unterarm[5-902.58 L] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Transorale Exzision und Destruktion Zungengrundtonsille[5-284.0 ] \ No newline at end of file diff --git a/598/patient_clinical_data.json b/598/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..00e488a28c0a10925e1a541bfdd92570ca00d87f --- /dev/null +++ b/598/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/598/patient_pathological_data.json b/598/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..75f4a69e2fd0d17eef5540588cf2eb83253bc327 --- /dev/null +++ b/598/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "598", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/598/surgery_description.txt b/598/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..71c91844c2c3af642efba4df70d392fc3ef64aa7 --- /dev/null +++ b/598/surgery_description.txt @@ -0,0 +1 @@ +TU-Resektion, Neck dissection bds., Defektdeckung (Radialis), PEG-u.Tracheostoma-Anlage diff --git a/598/surgery_report.txt b/598/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a746f6a44c0a21996c5e6c8649da25d58d7322e --- /dev/null +++ b/598/surgery_report.txt @@ -0,0 +1 @@ +After intubation by the anesthesia colleagues, pharyngoscopy and laryngoscopy again. This shows the deep ulcerated tumor with palpable infiltration even beyond the visible tumor borders. This once again confirmed the indication for surgery. Subsequently, PEG placement. PEG placement (/): Entering with the gastroesophagoscope and pre-scanning into the stomach under air insufflation. Spontaneous diaphanoscopy is given here, therefore indication for PEG insertion using the thread pull-through method. This was performed without any problems. Withdrawal of the endoscope. Then sterile draping and skin disinfection of all relevant surgical areas including the left forearm and right thigh. Tracheotomy (/PJ): Due to the planned incision for the neck dissection, vertical incision on both sides for the tracheotomy. Exposure of the infrahyoid musculature. Entering the midline. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Entering the trachea between the 2nd and 3rd tracheal clasp. Insertion of a visor tracheotomy in the typical manner. The mucocutaneous anastomosis is performed using Ethibond sutures. An 8-gauge cannula is inserted. Neck dissection on the right: Incision at the anterior edge of the sternocleidomastoid muscle in a curved line. Skin incision with the 15 mm scalpel. Skin is cut through. Subcutaneous tissue and platysma. Exposure of the anterior margin of the sternocleidomastoid muscle, lifting of the skin platysma flap. Exposure of the omohyoid muscle, internal jugular vein posterior to the digastric muscle and submandibular gland and accessory nerve. Now start with the release of the neck preparation in level IIb to level Vb. The branches of the cervical plexus are largely spared. The accessorius nerve is also spared. The vagus nerve is also spared, the hypoglossus is exposed and spared and the cervical artery and external carotid artery are also exposed and spared. Level IIa, IIb, III, IV, Va and Vb were thus evacuated. Punctual hemostasis and two-layer wound closure using 4-0 Vicryl and 5-0 Ethilon. Prior to this, placement of a 10-gauge Redon drain. Neck dissection on the left (dictation ): Incision on the anterior edge of the sternocleidomastoid muscle in a curved line. Skin incision with a 15 mm scalpel. Skin is cut through. Subcutaneous tissue and platysma. Exposure of the anterior border of the sternocleidomastoid muscle, lifting of the skin platysma flap. Exposure of the omohyoid muscle, the posterior venter of the digastric muscle of the submandibular gland and the accessorius nerve. Exposure of the internal jugular vein and the jugulofacial angle. This shows a metastasis that is connected to the internal jugular vein and facial vein and is carefully dissected off. Now start with the release of the remaining neck preparation in level Ib to level Vb. The branches of the cervical plexus are spared. The accessorius nerve is also spared. The vagus nerve is also visualized and spared. The hypoglossal nerve is visualized and spared as well as the cervical artery. The common, internal and external carotid arteries are now exposed and the superior thyroid artery, the facial artery and the ascending pharyngeal artery are dissected as possible connecting vessels. Levels Ib, IIa, IIb, III, IV, Va and Vb were therefore evacuated. Subsequently, combined transcervical and transoral tumor resection: Firstly, from the cervical side, dissection of the large neck vessels and dissection of the pharyngeal tube. This particularly concerns the external and internal carotid arteries. Exposure of the hypoglossal nerve and the vagus nerve, which are secured together with the cervical vascular sheath and the corresponding vessels using a vessel loop. Also exposure and preservation of the border cord. Stripping of the pharyngeal tube. The facial artery is already severed here. A large branch of the external carotid artery in the direction of the tonsil ligature is also ligated twice. Subsequent resection of the tumor: safety margin of at least 1.5 cm macroscopically. The palatal arch on the left falls away completely from the uvula, larger parts of the thyroid muscles, resection extends over the alveolar ridge, the glossoalveolar junction and into the base of the tongue. The lingual nerve cannot be preserved. Complete resection of the pharyngeal wall including parts of the base of the tongue. The submandibular gland is included in the preparation from the outside. The specimen is then marked with sutures and marginal samples are taken from the lateral alveolar ridge from the cranial side in the area of the palate and from the medial side from the palatal arch area to the beginning of the posterior pharyngeal wall. All marginal samples and also the entire tumor specimen in healthy tissue, i.e. R0 situation. This is followed by careful hemostasis. Measurement of the defect 10 x 8-9 cm. Now elevation of the radial flap: Dictation of skin incision and dissection through the subcutaneous fatty tissue. Locate the cephalic vein and dissect it radially. Finding and dissection of the pedicle between the muscle bellies of the brachioradialis and flexor carpi radialis muscles in depth. Dissection of the venous star. Dissection of the cephalic vein, an accompanying vein and the interosseous vein as possible connecting vessels. Dissection of the radial artery up to the brachial artery. Now incision of the ulnar flap and subfascial dissection. Incision of the radial end of the flap with inclusion of the cephalic vein in the flap. This extends relatively far radially here. Further dissection of the pedicle with clipping of the perforator vessels. Further saturation of 100% after removal of the flap. Then suture the radial flap into the defect. This is done using 3-0 Vicryl single-button sutures, partly with pre-positioning. A tension-free and complete reconstruction of all areas is achieved. Then vascular sutures. Conditioning of the radial artery and the facial artery. Suture using 8-0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. Subsequent conditioning of a V. thyroidea media and an outlet from the V. facialis. This is done using 3-0 and 2.5 mm couplers. In each case, good venous return after opening the clamps, positive smear phenomenon. Subsequent careful hemostasis. Irrigation. Layered wound closure on the right with insertion of a Redon drainage on the left with insertion of 2 flaps. Removal of split skin from the right thigh and closure of the left forearm with insertion of the split skin graft (dictation /) Removal of the split skin from the right thigh with the dermatome in the usual manner. Subsequent apposition of the arm. Insertion of a size 9 tracheostomy tube, followed by completion of the procedure without complications. Patient received Unacid intraoperatively. Please continue antibiotics for one week postoperatively. Please check the flap enorally and if necessary by Doppler according to the scheme for 5 days. Continue heparin perfusor at 1 mg per hour for about 5 days. Feeding via the inserted PEG tube for at least 10-12 days, then gruel and, if necessary, start to build up the diet. Overall cT2-3 oropharyngeal carcinoma on the left. Suspicious lymph nodes on both sides. Please wait for the final histology. Then presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/599/InvasionFront_CD3_block21_x1_y6_patient599_0.json b/599/InvasionFront_CD3_block21_x1_y6_patient599_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cf752f4ea2de027062fceb55f6efb5c47d20a2fc --- /dev/null +++ b/599/InvasionFront_CD3_block21_x1_y6_patient599_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 24986.8, + "Num Detections": 12494, + "Num Negative": 10827, + "Num Positive": 1667, + "Positive %": 13.34, + "Num Positive per mm^2": 1125.7 + } +} \ No newline at end of file diff --git a/599/InvasionFront_CD3_block21_x2_y6_patient599_1.json b/599/InvasionFront_CD3_block21_x2_y6_patient599_1.json new file mode 100644 index 0000000000000000000000000000000000000000..199848a87852e7cc49f81596791c89fbff193325 --- /dev/null +++ b/599/InvasionFront_CD3_block21_x2_y6_patient599_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8795.3, + "Centroid Y µm": 25261.6, + "Num Detections": 16761, + "Num Negative": 14673, + "Num Positive": 2088, + "Positive %": 12.46, + "Num Positive per mm^2": 1030.8 + } +} \ No newline at end of file diff --git a/599/InvasionFront_CD8_block21_x1_y6_patient599_0.json b/599/InvasionFront_CD8_block21_x1_y6_patient599_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ace344d8f8dc2d3e63eac9002b89b6ab6f9fc144 --- /dev/null +++ b/599/InvasionFront_CD8_block21_x1_y6_patient599_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3448.2, + "Centroid Y µm": 14767.2, + "Num Detections": 18857, + "Num Negative": 16303, + "Num Positive": 2554, + "Positive %": 13.54, + "Num Positive per mm^2": 1094.3 + } +} \ No newline at end of file diff --git a/599/InvasionFront_CD8_block21_x2_y6_patient599_1.json b/599/InvasionFront_CD8_block21_x2_y6_patient599_1.json new file mode 100644 index 0000000000000000000000000000000000000000..373f08ed080f20bb0df659311c222f94a9f6aa85 --- /dev/null +++ b/599/InvasionFront_CD8_block21_x2_y6_patient599_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 14817.2, + "Num Detections": 18532, + "Num Negative": 17293, + "Num Positive": 1239, + "Positive %": 6.686, + "Num Positive per mm^2": 551.7 + } +} \ No newline at end of file diff --git a/599/TumorCenter_CD3_block21_x1_y6_patient599_0.json b/599/TumorCenter_CD3_block21_x1_y6_patient599_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e590d3e7b617ac3972d41bdc9ed287d7910dbb36 --- /dev/null +++ b/599/TumorCenter_CD3_block21_x1_y6_patient599_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 17865.5, + "Num Detections": 15051, + "Num Negative": 14950, + "Num Positive": 101, + "Positive %": 0.6711, + "Num Positive per mm^2": 58.74 + } +} \ No newline at end of file diff --git a/599/TumorCenter_CD3_block21_x2_y6_patient599_1.json b/599/TumorCenter_CD3_block21_x2_y6_patient599_1.json new file mode 100644 index 0000000000000000000000000000000000000000..89c7ec225476802d3af862f09bf0553a30b55f58 --- /dev/null +++ b/599/TumorCenter_CD3_block21_x2_y6_patient599_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5821.9, + "Centroid Y µm": 17815.6, + "Num Detections": 13184, + "Num Negative": 13050, + "Num Positive": 134, + "Positive %": 1.016, + "Num Positive per mm^2": 84.51 + } +} \ No newline at end of file diff --git a/599/TumorCenter_CD8_block21_x1_y6_patient599_0.json b/599/TumorCenter_CD8_block21_x1_y6_patient599_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad130fb15f444146c770a0a2e113d6110574cd9b --- /dev/null +++ b/599/TumorCenter_CD8_block21_x1_y6_patient599_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 29784.2, + "Num Detections": 15530, + "Num Negative": 15419, + "Num Positive": 111, + "Positive %": 0.7147, + "Num Positive per mm^2": 64.2 + } +} \ No newline at end of file diff --git a/599/TumorCenter_CD8_block21_x2_y6_patient599_1.json b/599/TumorCenter_CD8_block21_x2_y6_patient599_1.json new file mode 100644 index 0000000000000000000000000000000000000000..752c0ccf9a1e639b1880b72bf3220a9d9a22d471 --- /dev/null +++ b/599/TumorCenter_CD8_block21_x2_y6_patient599_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8445.5, + "Centroid Y µm": 29584.3, + "Num Detections": 14524, + "Num Negative": 14397, + "Num Positive": 127, + "Positive %": 0.8744, + "Num Positive per mm^2": 64.7 + } +} \ No newline at end of file diff --git a/599/history_text.txt b/599/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e881cce9240fb4713ebb29917057e21670a47271 --- /dev/null +++ b/599/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy, the patient was diagnosed with a second tumor in the form of a supraglottic laryngeal carcinoma on the right side. Due to the patient's condition following radiochemotherapy of up to 64 Gy in the past, a tumor resection was indicated. \ No newline at end of file diff --git a/599/icd_codes.txt b/599/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b2b94cb50933cfa2488a2941aa728866a25f7e3 --- /dev/null +++ b/599/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 ] \ No newline at end of file diff --git a/599/ops_codes.txt b/599/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c7f07edf48aeb633184ddc5f317306b5f3921c71 --- /dev/null +++ b/599/ops_codes.txt @@ -0,0 +1 @@ +Epiglottektomie endolaryngeal[5-302.0 ] Exzision erkranktes Gewebe Larynx endolaryngeal[5-300.0 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/599/patient_clinical_data.json b/599/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cfa7d3f6ce5013dd02c4bc33923fc6ba5c081139 --- /dev/null +++ b/599/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/599/patient_pathological_data.json b/599/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a6e846b45b7b7378361dad8a1e27ebc1e31e8f40 --- /dev/null +++ b/599/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "599", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/599/surgery_description.txt b/599/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f12bcdf7d4595a98844de8bad68bbff00ff7b50 --- /dev/null +++ b/599/surgery_description.txt @@ -0,0 +1 @@ +Supraglottische Kehlkopfteilresektion diff --git a/599/surgery_report.txt b/599/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..476ab95d46a2b1cdd5ca072182b5302e9d724e49 --- /dev/null +++ b/599/surgery_report.txt @@ -0,0 +1 @@ +Panendoscopy at the beginning of the operation. This shows a tumor island in the area of the arytenoid hump on the left side. Otherwise, a main tumor mass can be seen in the area of the pocket crease on the right side, which completely occupies it and also extends from here towards the morgue sinus. From here, the tumor extends into the area of the anterior commissure and appears to cross it at the median line. The glottic plane itself appears to be tumor-free. The panendoscopy is then completed with otherwise unremarkable mirror conditions. After repositioning the patient, inject local anesthetic with adrenaline pretracheally. Then transverse incision above the trachea and preparation in depth. Locate the prelaryngeal muscles, which are cut in the median plane. Further preliminary preparation in depth and exploration of the thyroid isthmus. As this is only very small, it is only coagulated extensively and then cut. Exposure of the anterior surface of the trachea. Now open the trachea between the 2nd and 3rd cartilage clasp. Preparation of a Björk flap. Then circular suturing of the tracheostoma and insertion of a size 7 tracheostomy tube after extubation of the patient. The patient is then repositioned for the TORS procedure. Insert the LARS blocker for this. Exposure of the epiglottis. Then perform an epiglottectomy from the base of the tongue. The incision is made with the monopolar over the plica pharyngoepiglottica backwards to the arya. Here, horizontal placement above the ary, taking along the tumor island located on the median surface. From here, resect endolaryngeally down to the pocket fold level. Here, the tumor is then deposited on the upper edge of the morgue sinus. The dissection is then continued ventrally. Then vertically split the epiglottis and initially remove the left part of the tumor up to the anterior commissure. The hemiepiglottectomy is then performed on the right side. Preservation of the pharyngoepiglottic plica. The entire ary appears not to be covered by the tumor. Therefore, only resection of the entire pocket fold up to the lower edge of the morgue sinus, the upper part of which also appears to be infiltrated by the tumor. From here, resection into the anterior commissure, where the tumor can be removed. The tumor is then resected in the area of the anterior commissure. This specimen is sent separately for histopathological examination. Now take marginal samples from the anterior commissure on the ary on the left side. The separate samples of the anterior commissure and the arytenoid region on the left are sent for frozen section diagnostics. The samples are found to be tumor-free by the pathologist. Therefore, after careful bleeding control, no further measures are taken. A nasogastric feeding tube is then inserted and the procedure is completed after removal of the Lars blocker. Initially nutrition via the nasogastric tube for the next 5 days. Then slowly build up oral nutrition depending on the tendency to aspirate. In a second session, neck dissection must be planned on both sides in 2-3 weeks. If the feeding is successful without aspiration, the tracheostoma can be closed during this session if necessary. \ No newline at end of file diff --git a/600/InvasionFront_CD3_block6_x1_y4_patient600_0.json b/600/InvasionFront_CD3_block6_x1_y4_patient600_0.json new file mode 100644 index 0000000000000000000000000000000000000000..94bc6379b78db75cbc4e1ee797f11dd4e19619c1 --- /dev/null +++ b/600/InvasionFront_CD3_block6_x1_y4_patient600_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5014.1, + "Centroid Y µm": 10000.2, + "Num Detections": 9935, + "Num Negative": 9757, + "Num Positive": 178, + "Positive %": 1.792, + "Num Positive per mm^2": 142.51 + } +} \ No newline at end of file diff --git a/600/InvasionFront_CD3_block6_x2_y4_patient600_1.json b/600/InvasionFront_CD3_block6_x2_y4_patient600_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c60bfdaa6081885b91f462fe812694879211d097 --- /dev/null +++ b/600/InvasionFront_CD3_block6_x2_y4_patient600_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7471.0, + "Centroid Y µm": 10219.6, + "Num Detections": 19413, + "Num Negative": 19227, + "Num Positive": 186, + "Positive %": 0.9581, + "Num Positive per mm^2": 79.95 + } +} \ No newline at end of file diff --git a/600/InvasionFront_CD8_block6_x1_y2_patient600_0.json b/600/InvasionFront_CD8_block6_x1_y2_patient600_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba4469aea89de4210f7514f923ed7bfaff153de8 --- /dev/null +++ b/600/InvasionFront_CD8_block6_x1_y2_patient600_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5372.2, + "Centroid Y µm": 4422.7, + "Num Detections": 25254, + "Num Negative": 24548, + "Num Positive": 706, + "Positive %": 2.796, + "Num Positive per mm^2": 282.58 + } +} \ No newline at end of file diff --git a/600/InvasionFront_CD8_block6_x2_y2_patient600_1.json b/600/InvasionFront_CD8_block6_x2_y2_patient600_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7b63bbf17a7b613b18ca9161090a02596a2bd3dc --- /dev/null +++ b/600/InvasionFront_CD8_block6_x2_y2_patient600_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7970.8, + "Centroid Y µm": 4547.6, + "Num Detections": 23800, + "Num Negative": 23312, + "Num Positive": 488, + "Positive %": 2.05, + "Num Positive per mm^2": 191.73 + } +} \ No newline at end of file diff --git a/600/TumorCenter_CD3_block6_x1_y2_patient600_0.json b/600/TumorCenter_CD3_block6_x1_y2_patient600_0.json new file mode 100644 index 0000000000000000000000000000000000000000..124c6f7310f87a4ded3ddf730707dcaaab78e047 --- /dev/null +++ b/600/TumorCenter_CD3_block6_x1_y2_patient600_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 5172.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/600/TumorCenter_CD3_block6_x2_y2_patient600_1.json b/600/TumorCenter_CD3_block6_x2_y2_patient600_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cc82aa49184147cb5ede899e317eeb7fd819c43f --- /dev/null +++ b/600/TumorCenter_CD3_block6_x2_y2_patient600_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 5197.2, + "Num Detections": 24883, + "Num Negative": 23486, + "Num Positive": 1397, + "Positive %": 5.614, + "Num Positive per mm^2": 537.1 + } +} \ No newline at end of file diff --git a/600/TumorCenter_CD8_block6_x1_y2_patient600_0.json b/600/TumorCenter_CD8_block6_x1_y2_patient600_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1a2c3a2f9f3614f22733fa298337158f3b3c7e64 --- /dev/null +++ b/600/TumorCenter_CD8_block6_x1_y2_patient600_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 5447.1, + "Num Detections": 4483, + "Num Negative": 4412, + "Num Positive": 71, + "Positive %": 1.584, + "Num Positive per mm^2": 162.26 + } +} \ No newline at end of file diff --git a/600/TumorCenter_CD8_block6_x2_y2_patient600_1.json b/600/TumorCenter_CD8_block6_x2_y2_patient600_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a0523ce67008940a1c2a1c7140fff96f3143d2a8 --- /dev/null +++ b/600/TumorCenter_CD8_block6_x2_y2_patient600_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 5497.1, + "Num Detections": 25665, + "Num Negative": 25468, + "Num Positive": 197, + "Positive %": 0.7676, + "Num Positive per mm^2": 77.33 + } +} \ No newline at end of file diff --git a/600/history_text.txt b/600/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..523427c5ea4fa5fcabb660a51ee9effdda4f2e2d --- /dev/null +++ b/600/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 cN0 oral cavity carcinoma on the left was confirmed histologically as part of a panendoscopy. In our interdisciplinary tumor conference, indication for primary surgical procedure. \ No newline at end of file diff --git a/600/icd_codes.txt b/600/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45838eac835faac8966753fb0b91b54be81850ff --- /dev/null +++ b/600/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Gaumen und Uvula[C05.8 ] \ No newline at end of file diff --git a/600/ops_codes.txt b/600/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..43650385fade14e765d951cf0dad133dc0e61383 --- /dev/null +++ b/600/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.93 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Entnahme Vollhaut zur Transplantation Leisten- und Genitalregion[5-901.1c ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Anlage eines Systems zur Vakuumversiegelung an Haut und Unterhaut[5-916.a0 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] \ No newline at end of file diff --git a/600/patient_clinical_data.json b/600/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c67c3980603dac87a38e4b9d61df2fe98d92e489 --- /dev/null +++ b/600/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/600/patient_pathological_data.json b/600/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ea79964ecb4ae0a2658ee8c61c68dbf749433058 --- /dev/null +++ b/600/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "600", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/600/surgery_description.txt b/600/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0d8e223131c695c837392fa47c8794fe7b601c0 --- /dev/null +++ b/600/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Free flap (Radial), Tracheotomy diff --git a/600/surgery_report.txt b/600/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3b0a11525a4c8a20fa9bccc48e2330cdd107c250 --- /dev/null +++ b/600/surgery_report.txt @@ -0,0 +1 @@ +First, after preparation by the anesthesia colleagues, inspection of the primary tumor. An exulcerated tumor of the left soft palate with a depleted uvula was found. Submucosal infiltration of the soft palate approx. 1 cm with a pronounced small cone of just under 2 cm on the left. The submucosal lesion extends to the upper pole of the tonsil, the suspicious change extends to half of the left tonsil, otherwise the tumor can also be palpated. First of all, perform the PEG insertion. To do this, enter with the gastroscope under laryngoscopic control. Easy advancement into the stomach. After excellent diaphanoscopy, problem-free puncture of the stomach and placement of the PEG tube size 15 Charričre using the usual suture pull-through method. Subsequent repositioning for tumor resection, this is done transorally. Insertion of the tonsil plug, cutting around the tumor with a safety margin of just under 1 cm. Resection with monopolar needle and dissection technique. Subtotal resection of the soft palate on the left. Resection up to the upper tonsil pole on the right, left-sided removal of the anterior palatal arch and performance of a tonsillectomy in the area of the regular and unchanged capsule. Deposition at the base of the tongue with macroscopically inconspicuous conditions. Completely covering marginal samples are now taken both on the specimen and in situ. These are diagnosed as completely tumor-free in the frozen section diagnosis. Therefore, intraoperative R0 situation, meticulous hemostasis and measurement of the defect measuring up to 8 x 5.5 in total in dry wound conditions. If tongue swelling has already clearly set in after tumor resection, a shot tracheotomy is performed later. First turn to neck dissection of the left side. To do this, make a submandibular incision approx. 2 QF below the lower jaw, cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure and preservation of the external jugular vein, exposure of the sternocleidomastoid muscle, the omohyoid muscle and the digasatric muscle. Exposure of the submandibular gland, removal of the anterior neck preparation with careful protection of the cervical sinus, the hypoglossal nerve, the facial vein and the superior thyroid artery. Free preparation of the internal jugular vein. Exposure of the accessorius nerve. Clearing of the accessorius triangle and the upper level Va with careful protection of the cervical plexus branches. The submandibular gland is excised later. Subcapsular procedure and preservation of the oral branch. The facial vein is later removed for reasons of space. Exposure and preservation of the facial artery initially, which is later also ligated and removed. Resection of the digastric muscle. Entering pharyngeally at the level of the caudal tonsil lobes. Widen the pharyngotomy up to a width of approx. 3 QF, finally wide and soft conditions for subsequent pedicle positioning. Turn to the neck dissection of the right side. Also corresponding to the opposite side, skin incision, cutting through skin and subcutaneous tissue. Exposure and dissection of the platysma. Exposure and preservation of the external jugular vein. Exposure of the sternocleidomastoid muscle, omohyoid muscle, exposure of the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the cervical anus, the hypoglossal nerve, the superior thyroid artery and the facial vein. Free preparation of the internal jugular vein. Exposure of the accessorius nerve. Dissection of the accessorius triangle and the upper level Va, carefully preserving the cervical plexus branches. Final inspection and, if conditions are dry, wound irrigation, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Now turn to lifting the radialis graft from the left forearm. After marking the graft, which measures 9 x 5.5 in total and has a special soft palate configuration, the tourniquet is applied. Cutting around the graft. Exposure and entrainment of the distal cephalic vein. Performing the Haydn maneuver. Identification of the ramus superficialis nervi radialis. Ulnar exposure of the musculature, strictly subfascial approach here. Identification of the distal vascular pedicle, removal of the vasa radialia after ligation, strictly subfascial preparation, the ulnar vascular nerve bundle is not exposed. Subfascial release of the graft and proximal dissection after exposure of the strong ulnar artery, isolation of the radial artery, exposure and preservation of the common interosseous artery, exposure of a narrow bridge between the cephalic vein and the deep venous drainage system, but with strong venous confluence here, the deep venous confluence is later prepared for primary anastomosis. Isolation of the veins. Reopening of the tourniquet with excellent flap vitality Careful hemostasis is performed on the graft and the forearm. There is better venous flow for the deep draining vein, therefore ligation of the cephalic vein. A monitor was not used as the graft was clearly visible. Subsequently, the vital graft was removed after ligation of the draining vessels. The graft was then removed, the wound carefully closed in two layers and the full-thickness skin graft harvested from the right groin was inserted. Then application of the vacuum-sealing dressing and application of the stretcher splint in the functional site. Removal of the full-thickness skin graft. To do this, mark the graft oval, lift a graft of approx. 11 x 5 cm, cut around the oval, strictly cutaneous lifting. Careful subcutaneous mobilization. Subsequent insertion of a 10-gauge Redon drain with dry wound conditions and strong multi-layer wound closure. Subsequent skin suturing. The plastic tracheotomy was performed at the same time as the radialis graft removal. For this purpose, a horizontal skin incision was made at the level of the cricoid cartilage to separate the skin and subcutaneous tissue. Exposure of the infrahyoid musculature, separation of the musculature, exposure of the cricoid cartilage and the anterior surface of the trachea. Exposure of the thyroid isthmus, transection of the thyroid isthmus after ligation and repositioning. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap. Incision of the tracheostoma in the usual manner and subsequent problem-free reintubation to a size 9 low cuff cannula. After insertion of the graft from cervical to enoral, adaptive incision of the graft is performed, overall good fit, subsequent tightness on all sides. Left-sided positioning of the vascular pedicle. Conditioning of the flap vascular pedicle, followed by conditioning of the superior thyroid artery. Careful suturing of the arteries with 8.0 Ethilon. Due to the repositioning, the intake conditions were considerably more difficult, but subsequently the flow conditions were problem-free and sufficient and venous return was immediate and regular. Conditioning facial vein, which despite previous deposition ........ flow conditions. Measurement of a size 3.0 coupler and problem-free implementation of the venous anastomosis with the coupler, followed by good flow conditions and vital enoral graft, so that after final wound inspection, a 10-gauge Redon drain was inserted, careful two-layer wound closure and termination of the procedure with a vital graft and transfer of the patient to the intensive care unit. The patient received antibiotic prophylaxis with Unacid 3 g. Conclusion: Intraoperative R0 resected cT2 cN0 oral cavity carcinoma on the left, abstinence from food initially for 7-8 days, then with regular enoral healing, gradual food build-up and decannulation with regular swallowing function. \ No newline at end of file diff --git a/601/InvasionFront_CD3_block7_x5_y12_patient601_0.json b/601/InvasionFront_CD3_block7_x5_y12_patient601_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4e8495eca2b70159d7d18bec7cf82dac12347ff2 --- /dev/null +++ b/601/InvasionFront_CD3_block7_x5_y12_patient601_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 28834.7, + "Num Detections": 19614, + "Num Negative": 12269, + "Num Positive": 7345, + "Positive %": 37.45, + "Num Positive per mm^2": 3304.3 + } +} \ No newline at end of file diff --git a/601/InvasionFront_CD3_block7_x6_y12_patient601_1.json b/601/InvasionFront_CD3_block7_x6_y12_patient601_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5bad4cb1ebebd27a83d1d5f482cf0e6f36d64f41 --- /dev/null +++ b/601/InvasionFront_CD3_block7_x6_y12_patient601_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 28959.7, + "Num Detections": 14575, + "Num Negative": 12925, + "Num Positive": 1650, + "Positive %": 11.32, + "Num Positive per mm^2": 994.13 + } +} \ No newline at end of file diff --git a/601/InvasionFront_CD8_block7_x5_y12_patient601_0.json b/601/InvasionFront_CD8_block7_x5_y12_patient601_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c33e831ad848e00df6b188f99a83df658c9814e3 --- /dev/null +++ b/601/InvasionFront_CD8_block7_x5_y12_patient601_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15591.7, + "Centroid Y µm": 30583.8, + "Num Detections": 21017, + "Num Negative": 12138, + "Num Positive": 8879, + "Positive %": 42.25, + "Num Positive per mm^2": 3698.2 + } +} \ No newline at end of file diff --git a/601/InvasionFront_CD8_block7_x6_y12_patient601_1.json b/601/InvasionFront_CD8_block7_x6_y12_patient601_1.json new file mode 100644 index 0000000000000000000000000000000000000000..161eeacaac2ee170b3a24fd2d1b42cc92a079416 --- /dev/null +++ b/601/InvasionFront_CD8_block7_x6_y12_patient601_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18015.5, + "Centroid Y µm": 30883.6, + "Num Detections": 17940, + "Num Negative": 15720, + "Num Positive": 2220, + "Positive %": 12.37, + "Num Positive per mm^2": 1040.8 + } +} \ No newline at end of file diff --git a/601/TumorCenter_CD3_block7_x5_y12_patient601_0.json b/601/TumorCenter_CD3_block7_x5_y12_patient601_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89413f506889434fc8e24ad3f0953dda5d5a2426 --- /dev/null +++ b/601/TumorCenter_CD3_block7_x5_y12_patient601_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 30259.0, + "Num Detections": 19742, + "Num Negative": 11470, + "Num Positive": 8272, + "Positive %": 41.9, + "Num Positive per mm^2": 3408.0 + } +} \ No newline at end of file diff --git a/601/TumorCenter_CD3_block7_x6_y12_patient601_1.json b/601/TumorCenter_CD3_block7_x6_y12_patient601_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e897a67a763054090b5035cdf84877b4ceff9d4 --- /dev/null +++ b/601/TumorCenter_CD3_block7_x6_y12_patient601_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18265.3, + "Centroid Y µm": 30234.0, + "Num Detections": 18586, + "Num Negative": 11412, + "Num Positive": 7174, + "Positive %": 38.6, + "Num Positive per mm^2": 3032.0 + } +} \ No newline at end of file diff --git a/601/TumorCenter_CD8_block7_x5_y12_patient601_0.json b/601/TumorCenter_CD8_block7_x5_y12_patient601_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dc25f58856aedf593a0bd269120d343549bd453c --- /dev/null +++ b/601/TumorCenter_CD8_block7_x5_y12_patient601_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15466.8, + "Centroid Y µm": 29834.2, + "Num Detections": 19341, + "Num Negative": 10845, + "Num Positive": 8496, + "Positive %": 43.93, + "Num Positive per mm^2": 3758.9 + } +} \ No newline at end of file diff --git a/601/TumorCenter_CD8_block7_x6_y12_patient601_1.json b/601/TumorCenter_CD8_block7_x6_y12_patient601_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a60b81533509ecf54df3b80c7571df6b7759c0a7 --- /dev/null +++ b/601/TumorCenter_CD8_block7_x6_y12_patient601_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17965.5, + "Centroid Y µm": 29784.2, + "Num Detections": 18538, + "Num Negative": 11147, + "Num Positive": 7391, + "Positive %": 39.87, + "Num Positive per mm^2": 3161.3 + } +} \ No newline at end of file diff --git a/601/history_text.txt b/601/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..aa31e99ce40c8ea543de491d2950e81c5d0168a2 --- /dev/null +++ b/601/history_text.txt @@ -0,0 +1 @@ +Patient with suspected cT2 hypopharyngeal carcinoma on the left, now histologically confirmed. \ No newline at end of file diff --git a/601/icd_codes.txt b/601/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/601/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/601/ops_codes.txt b/601/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8975ccc6004a03130996036ad07228d49196dd63 --- /dev/null +++ b/601/ops_codes.txt @@ -0,0 +1 @@ +Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 4 Regionen[5-403.03 B] Permanente Tracheostomie: Tracheotomie[5-312.0 ] Laterale Pharyngotomie[5-290.3 ] Sonstige Exzision oder Destruktion Pharynxgewebe[5-292.x ] \ No newline at end of file diff --git a/601/patient_clinical_data.json b/601/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6e1373d4c4bb44c5d21e438cb5124c48dbecd78c --- /dev/null +++ b/601/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 56, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/601/patient_pathological_data.json b/601/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2f823bfc25f4765f177065f49f5a99c2bae926d5 --- /dev/null +++ b/601/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "601", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/601/surgery_description.txt b/601/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..be6a439d2e69fa718e2dc594b5e9b6e5f85aa723 --- /dev/null +++ b/601/surgery_description.txt @@ -0,0 +1 @@ +Excision of hypopharyngeal cancer, Bilateral neck dissection, Tracheotomy, PEG placement, Endoscopy diff --git a/601/surgery_report.txt b/601/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc612439ee84c8c732a74a50eb919c3c0ec18771 --- /dev/null +++ b/601/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Adjustment of the pharynx with the laryngoscope. Insertion of the flexible esophagoscope. Advance into the stomach: inconspicuous conditions there. If diaphanoscopy is good, PEG insertion in the usual way using the thread pull-through method. No bleeding. Perioperative administration of Unacid. Please continue this for a few days postoperatively. Hypopharyngoscopy performed again: After adjustment with the small water tube, the tumor at the entrance in the hypopharynx on the left can be seen very clearly, which is relatively easy to move and can be pushed away from the arytenoid cartilage. Decision to perform a neck dissection on both sides with tracheotomy and lateral pharyngotomy with tumor extirpation. Repositioning of the patient and skin disinfection. Infiltration anesthesia in the area of the right and left side of the neck. Start on the left. Marking of a platysmal flap. Cut around the platysmal flap and dissect it as far as the submandibular gland. At the same time, perform the neck dissection, cutting through the subcutaneous tissue. Exposure of the sternocleidomastoid muscle after dissection of the platysmal flap medially. Exposure of the internal jugular vein, the facial vein, which remains intact. Exposure, displacement, neurolysis and re-embedding of the vagus nerve and the accessorius nerve. Exposure of the posterior digastric venter muscle. Dissection of the posterior neck preparation, first clearing level IIb, then continuing cranially to IV beginning V. After detachment and transection of the omohyoid muscle, finally transection of the fatty tissue and its supraclavicular transection. Removal of the posterior neck preparation. Now dissect anteriorly. Removal of the capsule of the submandibular gland. Exposure, displacement, neurolysis and re-embedding of the hypoglossal nerve. Exposure of the superior thyroid artery and the superior laryngeal nerve. Preparation of the anterior neck specimen and also submission for definitive histology. Exposure of the upper edge of the thyroid cartilage and the posterior edge. Removal of the upper horn of the thyroid cartilage and detachment of the piriform sinus from the thyroid cartilage. Resection of part of the thyroid cartilage. Entering the pharynx. Perform a lateral pharyngotomy below the hyoid bone. The tumor can be clearly seen at the entrance to the hypopharynx. It is circumcised in a circular fashion while sparing the laryngeal structures. The arytenoid hump is clearly visible but remains intact and part of the mucosa of the arytenoid hump must also be removed. In some cases, resection of part of the aryepiglottic fold. Removal of circular margin samples. These are all found to be tumor-free in the frozen section. Due to the relatively circumscribed defect, it is not necessary to create a flap. The platysmal flap is therefore moved back later. A primary multi-layered wound closure of the mucosa is now performed. This is very successful. The thyroid gland is dissected caudally, set down at the caudal pole and swung upwards to additionally reinforce the pharynx on this side and is stitched directly onto the pharyngeal suture. Extensive hemostasis with bipolar coagulation and irrigation with H2O2 and Ringer's solution. No more bleeding. Insertion of a Redon drain. Repositioning of the platysmal flap. Subcutaneous sutures, skin suture. Pressure bandage. Repositioning for neck dissection on the opposite side. Infiltration anesthesia. Skin incision on the anterior edge of the sternocleidomastoid muscle. Exposure of the muscle. Exposure of the internal jugular vein. Exposure, displacement, neurolysis and re-embedding of the accessorius nerve. Exposure of the posterior digastric venter muscle. Exposure, displacement, neurolysis and re-embedding of the vagus nerve. Development of the posterior neck preparation from cranial to caudal to the omohyoid muscle. Set down there and reposition the fatty tissue. Dissection of the anterior neck preparation, exposing the hypoglossal nerve. Displacement, neurolysis and re-embedding of the hypoglossal nerve. Dissection with the capsule of the submandibular gland and sparing of the facial vein. Complete evacuation of the anterior part of the neck. Hemostasis with H2O2 and bipolar coagulation. Irrigation with Ringer's solution. No more bleeding. Insertion of a Redon drain. Subcutaneous suture, skin suture and pressure dressing. Performing the tracheotomy: To do this, make a star-shaped incision over the jugulum. Dissection of the subcutaneous tissue. Exposure of the linea alba. Exposure of the thyroid isthmus. Separation and incision of the same. Exposure of the anterior tracheal wall and between the 2nd and 3rd tracheal cartilage now entering the trachea. Formation of a Björk flap. Epithelialization of the tracheostoma. Re-intubation of the patient and insertion of an 8-gauge Rügheimer cannula, which is currently blocked. The Rügheimer cannula is fixed to the skin with three sutures. No bleeding at the end of the procedure, no other special features. Detailed consultation with the anesthetist. The patient is transferred to the intensive care unit for monitoring. \ No newline at end of file diff --git a/602/InvasionFront_CD3_block9_x3_y5_patient602_0.json b/602/InvasionFront_CD3_block9_x3_y5_patient602_0.json new file mode 100644 index 0000000000000000000000000000000000000000..812a43773777f5b2b25bf6a0996d19e1f294c22d --- /dev/null +++ b/602/InvasionFront_CD3_block9_x3_y5_patient602_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 13143.0, + "Num Detections": 18004, + "Num Negative": 15713, + "Num Positive": 2291, + "Positive %": 12.72, + "Num Positive per mm^2": 1075.5 + } +} \ No newline at end of file diff --git a/602/InvasionFront_CD3_block9_x4_y5_patient602_1.json b/602/InvasionFront_CD3_block9_x4_y5_patient602_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e146ea4ae8ffde4652217c74c56a748c160169fe --- /dev/null +++ b/602/InvasionFront_CD3_block9_x4_y5_patient602_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15616.7, + "Centroid Y µm": 13392.9, + "Num Detections": 21185, + "Num Negative": 19104, + "Num Positive": 2081, + "Positive %": 9.823, + "Num Positive per mm^2": 851.81 + } +} \ No newline at end of file diff --git a/602/InvasionFront_CD8_block9_x3_y5_patient602_0.json b/602/InvasionFront_CD8_block9_x3_y5_patient602_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c47754290fb0adcdea40b164d1fcbe480977cb81 --- /dev/null +++ b/602/InvasionFront_CD8_block9_x3_y5_patient602_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12743.3, + "Centroid Y µm": 17041.0, + "Num Detections": 17946, + "Num Negative": 16716, + "Num Positive": 1230, + "Positive %": 6.854, + "Num Positive per mm^2": 586.35 + } +} \ No newline at end of file diff --git a/602/InvasionFront_CD8_block9_x4_y5_patient602_1.json b/602/InvasionFront_CD8_block9_x4_y5_patient602_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8bd766b50c1f47e25abca0e04a9e45460f359eda --- /dev/null +++ b/602/InvasionFront_CD8_block9_x4_y5_patient602_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15391.9, + "Centroid Y µm": 17215.9, + "Num Detections": 20859, + "Num Negative": 19039, + "Num Positive": 1820, + "Positive %": 8.725, + "Num Positive per mm^2": 757.49 + } +} \ No newline at end of file diff --git a/602/TumorCenter_CD3_block9_x3_y5_patient602_0.json b/602/TumorCenter_CD3_block9_x3_y5_patient602_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c2a08da1cd5ef6f231edfb8c0f316cc3e8eb9c7f --- /dev/null +++ b/602/TumorCenter_CD3_block9_x3_y5_patient602_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 18190.4, + "Num Detections": 18626, + "Num Negative": 12284, + "Num Positive": 6342, + "Positive %": 34.05, + "Num Positive per mm^2": 2906.5 + } +} \ No newline at end of file diff --git a/602/TumorCenter_CD3_block9_x4_y5_patient602_1.json b/602/TumorCenter_CD3_block9_x4_y5_patient602_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ced877ec8a6a86583ed43350ba969ee0f3a8d19e --- /dev/null +++ b/602/TumorCenter_CD3_block9_x4_y5_patient602_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 18165.4, + "Num Detections": 18598, + "Num Negative": 16650, + "Num Positive": 1948, + "Positive %": 10.47, + "Num Positive per mm^2": 879.63 + } +} \ No newline at end of file diff --git a/602/TumorCenter_CD8_block9_x3_y5_patient602_0.json b/602/TumorCenter_CD8_block9_x3_y5_patient602_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0ba7b3bbecf156edf409bc111e00760bbfd197ce --- /dev/null +++ b/602/TumorCenter_CD8_block9_x3_y5_patient602_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 13417.9, + "Num Detections": 18154, + "Num Negative": 13798, + "Num Positive": 4356, + "Positive %": 23.99, + "Num Positive per mm^2": 2078.2 + } +} \ No newline at end of file diff --git a/602/TumorCenter_CD8_block9_x4_y5_patient602_1.json b/602/TumorCenter_CD8_block9_x4_y5_patient602_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3c0aeded1147e33f89bfca1c9693d26a561085f --- /dev/null +++ b/602/TumorCenter_CD8_block9_x4_y5_patient602_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 13268.0, + "Num Detections": 17854, + "Num Negative": 16785, + "Num Positive": 1069, + "Positive %": 5.987, + "Num Positive per mm^2": 490.5 + } +} \ No newline at end of file diff --git a/602/history_text.txt b/602/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..506684422cf709f6e14400f422b26d3033139ecf --- /dev/null +++ b/602/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tonsillar carcinoma on the right with extension to the palatal arch and towards the pharyngeal wall. On CT, the tumor extends to the internal carotid artery, which shows kinking here. The above-mentioned operation is therefore indicated. \ No newline at end of file diff --git a/602/icd_codes.txt b/602/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/602/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/602/ops_codes.txt b/602/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a8a70ad4c634170d759dc57bef3b011a94dc5e6b --- /dev/null +++ b/602/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-296.24 ] Radikale Neck dissection in 4 Regionen[5-403.10 B] Temporäre Tracheotomie[5-311.0 ] Entnahme eines freien Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-904.0e R] Wechsel eines vaskulären Implantates[5-394.3 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/602/patient_clinical_data.json b/602/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7d6da43ce53e2036a64a59d3da2859dc5562a7a --- /dev/null +++ b/602/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/602/patient_pathological_data.json b/602/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..017103169cf17027e2692b8e570331f44dc340ed --- /dev/null +++ b/602/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "602", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/602/surgery_description.txt b/602/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c8d10050cd478f5b46e4d395bce65086f0f3f638 --- /dev/null +++ b/602/surgery_description.txt @@ -0,0 +1 @@ +Pharyngectomy, Neck dissection, Free flap (ALT), PEG placement diff --git a/602/surgery_report.txt b/602/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c91861c4b16731c4ee2cf55c8b6a7c27cabdf23e --- /dev/null +++ b/602/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy again: The exophytic tumor in the area of the tonsil lobe with transition to the palatal arch is confirmed, smaller flat extensions caudally onto the lateral wall of the oropharynx and towards the posterior wall of the oropharynx are visible. Therefore indication for surgery confirmed. PEG insertion: insertion of the flexible esophagoscope. After creating the diaphanoscopy, insertion of a 15 mm abdominal wall tube in a typical manner without complications. Positioning of the patient. Skin disinfection. Injection of a total of 20 ml Ultracaine 1% with adrenaline into both sides of the neck. First start with radical neck dissection on the right: skin incision typically widened slightly caudally. Depiction of the sternocleidomastoid muscle. This is infiltrated by lymph node metastases. Showing digastric muscle, omohyoid muscle. Depiction of the internal jugular vein, which is infiltrated cranially by the metastasis. Depiction of the common carotid artery, internal/external carotid artery. These can be dissected from the metastatic conglomerate. Depiction of the hypoglossal nerve. This must also be dissected. The nervus accessorius extends into the lymph node conglomerate and is also resected. Some branches of the cervical plexus, which are involved in the tumor, must also be resected in the cranial to middle area. The sternocleidomastoid muscle is removed caudally and cranially and also resected. Parts of the deep neck muscles in the cranial area must also be resected as they are also infiltrated. The internal jugular vein is removed caudally and cranially and ligated twice. However, the most caudal part of the internal jugular vein with an outgoing facial vein can be preserved for the vascular anastomosis. Vagus nerve border cords are exposed and preserved. Neck dissection on the left, performed by : Skin incision in typical manner. Exposure of the sternocleidomastoid muscle. Depiction of the omohyoid muscle, digastric muscle. Exposure of the internal jugular vein, facial vein, internal/external carotid artery, vagus nerve, accessorius nerve and hypoglossal nerve. All structures are visualized and preserved. Clearing from level II to V. This is also done while exposing and preserving all branches of the cervical plexus. Finally, careful hemostasis and wound closure in the typical manner with insertion of a Redon drain. Tracheostoma creation: Small Kocher collar incision. Dissection through subcutaneous tissue to the infrahyoid musculature. This is split. Thyroid isthmus, which is very small, is dissected after bipolar coagulation. The anterior wall of the trachea is exposed. The trachea is opened in the 2nd to 3rd intercartilaginous space and a wide-based, modified Björk flap is created. This is epithelized in the typical manner. Subsequently, reintubation with insertion of a Woodbridge tube. Then tumor resection combined transorally and transcervically: The tumor is first removed macroscopically from all sides transorally at a distance of at least 1 cm. The anterior palatal arch is completely removed and parts of the posterior palatal arch are removed. The tumor is removed along the tonsil capsule, as this is a good boundary layer. Glossoalveolar groove, marginal parts of the base of the tongue and the pharyngeal side wall up to just before the entrance to the hypopharynx are also removed. Tumor specimen is thread-marked and sent for frozen section. Similarly, a marginal sample from the medial edge of the pharyngeal wall at the border to the posterior wall. This is also thread-marked and sent for final histology. Here, there are very narrow gaps in the basal direction, so that a resection is recommended. Carcinoma in situ infiltrates are also found in the middle section of the marginal specimen in the medial direction of the pharyngeal wall, so that a resection is also necessary here. For the resection, the internal/external carotid artery was previously dissected and the kinking of the internal carotid artery was also separated from the pharyngeal wall. All soft tissue is now removed from the inside of the lower jaw from the cranial side next to the palatal arch down to the hyoid bone. All soft tissue remaining from the pharyngeal tube is removed. A wide resection is also obtained from the medial pharyngeal wall, which is marked with sutures remote from the tumor. The soft tissue margin sample and the margin sample from the medial pharyngeal wall are sent to the frozen section again. Here, no further tumor infiltrates are visible in the soft tissues. Only moderate dysplasia on the pharyngeal wall, no carinoma in situ. Thus now an R0 situation. There is a defect from the palatal arch next to the uvula down to the piriform sinus entrance. As no radial flap is possible, a thigh flap is removed to cover the defect: Several perforators can be made out in the line from the superior spina to the lateral patella and these are marked. After measuring the size of the flap, the dimension is 13 x 8 mm. This flap size is marked around the perforators accordingly. First make a skin incision medially up to the fascia. Then cut through the fascia. Depiction of the rectus femoris muscle. Incision is extended slightly cranially, between rectus femoris and vastus lateralis to find the ramus descencus. However, this does not run directly next to the vastus lateralis but into the muscle at the lower edge of the vastus lateralis. Departure of several perforators can be observed. Separation of the vastus in the medius from the intermuscular septum. The vascular pedicle is followed distally. Here the vascular pedicle is deposited in the caudal region. Then make a skin incision on the lateral side up to the fascia. After cutting through the fascia, successive lifting of the flap with muscle cuff. This muscle cuff is slightly enlarged as the vessels run into it from the caudal instead of the lateral side. Successive lifting of the muscle. Branches of the femoral nerve to the muscles are all preserved as far as possible. Subsequent dissection of the vascular pedicle up to the entrance of the artery into the profunda femoral artery. Outgoing smaller arterial vessels are ligated or clipped. Two accompanying veins are also lifted, outgoing vessels are ligated or clipped. Cranially, a confluence is divided into three outgoing vessels in front of the entrance to the femoral profunda vein. After complete elevation of the flap including the pedicle, there is good pulsation in the area of the descending ramus and at least two of the outgoing perforators. Blood flow in the flap is regular. Subsequently, the artery, which is cut off cranially with 4.0 prolene sutures, is removed using the puncture technique. The smaller outgoing veins are ligated. The outlet from the profunda femoral vein is treated with 4.0 prolene sutures over and under the vein. After removal of the flap, irrigation with heparin. The wound on the thigh is closed in layers after extensive hemostasis. The fascia is also sutured. Wound closure with insertion of two Redon drains. Now suture the flap into the defect. The flap is inserted into the neck in such a way that excessive tension between the skin and muscle in relation to the perforators is avoided. Successive suturing of the flap into the defect using 3.0 Vicryl single-button sutures, which is partly done by advancing the sutures. The flap can be sutured into the defect with relatively little tension and in a three-dimensionally correct manner. The vessels are then trimmed for the vascular suture. The facial artery is selected. This is sutured to the descending ramus after widening the lumen of the facial artery using the fish-mouth technique with 8.0 Ethilon single-button sutures. Trimming of the veins. The facial vein, which opens caudally into the still open internal jugular vein, is selected. This is anastomosed with the confluent vessel from the profunda femoral vein. A coupler size 3.0 is selected for this purpose. After opening the arterial clamp, good venous return or after opening the veins, good venous return, smear phenomenon positive. However, pulsation via the perforators is relatively weak. ......... Control brings little reflux. Disturbance in the perforator area, e.g. spasm, cannot be ruled out with certainty, but pulsation via the anastomoses and the large vessels is regular. Further measures currently not advisable. Therefore now careful hemostasis. Wound closure in layers with insertion of a flap. Skin closure on the left is also performed after hemostasis and insertion of a Redon drainage. Insertion of a size 8 tracheostomy tube, which is fixed with sutures. Completion of the procedure without complications. Overall cT2-3 tonsil/oropharyngeal carcinoma on the right. cN2b status required radical neck dissection. Defect coverage by means of thigh flap from the right side. Circulatory situation uncertain at the end. Patient transferred to the intensive care unit for monitoring. Here regular checks of flap perfusion according to schedule. Heparin perfusion, which was started intraoperatively at 500 units per hour, should be continued. Please continue antibiotics, which were started intraoperatively with Unacid, for one week. Feeding via the inserted PEG tube. Flap insufficiency due to perforator insufficiency possible, then defect closure preferably by means of pecoral major flap according to the clinical course. \ No newline at end of file diff --git a/603/InvasionFront_CD3_block16_x3_y7_patient603_0.json b/603/InvasionFront_CD3_block16_x3_y7_patient603_0.json new file mode 100644 index 0000000000000000000000000000000000000000..50da1aa4e07cbec0f6106c5f846e304142c0822d --- /dev/null +++ b/603/InvasionFront_CD3_block16_x3_y7_patient603_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11679.7, + "Centroid Y µm": 21961.6, + "Num Detections": 17968, + "Num Negative": 16174, + "Num Positive": 1794, + "Positive %": 9.984, + "Num Positive per mm^2": 803.37 + } +} \ No newline at end of file diff --git a/603/InvasionFront_CD3_block16_x4_y7_patient603_1.json b/603/InvasionFront_CD3_block16_x4_y7_patient603_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e5afd63f9908d38819eacf17b8c07c4bf7e0662 --- /dev/null +++ b/603/InvasionFront_CD3_block16_x4_y7_patient603_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14303.6, + "Centroid Y µm": 22084.9, + "Num Detections": 16378, + "Num Negative": 15135, + "Num Positive": 1243, + "Positive %": 7.589, + "Num Positive per mm^2": 580.93 + } +} \ No newline at end of file diff --git a/603/InvasionFront_CD8_block16_x3_y7_patient603_0.json b/603/InvasionFront_CD8_block16_x3_y7_patient603_0.json new file mode 100644 index 0000000000000000000000000000000000000000..712c59dd8b549e31cc02ab3f93ef722b5b1ed8b3 --- /dev/null +++ b/603/InvasionFront_CD8_block16_x3_y7_patient603_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10942.7, + "Centroid Y µm": 17340.8, + "Num Detections": 4658, + "Num Negative": 4364, + "Num Positive": 294, + "Positive %": 6.312, + "Num Positive per mm^2": 477.13 + } +} \ No newline at end of file diff --git a/603/InvasionFront_CD8_block16_x4_y7_patient603_1.json b/603/InvasionFront_CD8_block16_x4_y7_patient603_1.json new file mode 100644 index 0000000000000000000000000000000000000000..624e3cad5f9419f93438e6bfe9c5b68f942dc83a --- /dev/null +++ b/603/InvasionFront_CD8_block16_x4_y7_patient603_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 17340.8, + "Num Detections": 14867, + "Num Negative": 13143, + "Num Positive": 1724, + "Positive %": 11.6, + "Num Positive per mm^2": 914.79 + } +} \ No newline at end of file diff --git a/603/TumorCenter_CD3_block16_x3_y7_patient603_0.json b/603/TumorCenter_CD3_block16_x3_y7_patient603_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c10ceadbd4697e67de290ce7e3082c0613b8fe1 --- /dev/null +++ b/603/TumorCenter_CD3_block16_x3_y7_patient603_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 17915.5, + "Num Detections": 17845, + "Num Negative": 15773, + "Num Positive": 2072, + "Positive %": 11.61, + "Num Positive per mm^2": 900.95 + } +} \ No newline at end of file diff --git a/603/TumorCenter_CD3_block16_x4_y7_patient603_1.json b/603/TumorCenter_CD3_block16_x4_y7_patient603_1.json new file mode 100644 index 0000000000000000000000000000000000000000..abee24b7bce196607be52c615eaf5db49d2fb7a1 --- /dev/null +++ b/603/TumorCenter_CD3_block16_x4_y7_patient603_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14267.4, + "Centroid Y µm": 18190.4, + "Num Detections": 10665, + "Num Negative": 7474, + "Num Positive": 3191, + "Positive %": 29.92, + "Num Positive per mm^2": 2250.5 + } +} \ No newline at end of file diff --git a/603/TumorCenter_CD8_block16_x3_y7_patient603_0.json b/603/TumorCenter_CD8_block16_x3_y7_patient603_0.json new file mode 100644 index 0000000000000000000000000000000000000000..661d6591d9f7b2300ad36856153168e5c75bde86 --- /dev/null +++ b/603/TumorCenter_CD8_block16_x3_y7_patient603_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 17940.5, + "Num Detections": 19223, + "Num Negative": 17571, + "Num Positive": 1652, + "Positive %": 8.594, + "Num Positive per mm^2": 735.5 + } +} \ No newline at end of file diff --git a/603/TumorCenter_CD8_block16_x4_y7_patient603_1.json b/603/TumorCenter_CD8_block16_x4_y7_patient603_1.json new file mode 100644 index 0000000000000000000000000000000000000000..241ff2a368834a7b77447bc603ef1d9acd5a88e2 --- /dev/null +++ b/603/TumorCenter_CD8_block16_x4_y7_patient603_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 18015.5, + "Num Detections": 11091, + "Num Negative": 8637, + "Num Positive": 2454, + "Positive %": 22.13, + "Num Positive per mm^2": 1649.1 + } +} \ No newline at end of file diff --git a/603/history_text.txt b/603/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ebf1d85c2bb3d4c52d6c218000cae9578b78d6c7 --- /dev/null +++ b/603/history_text.txt @@ -0,0 +1 @@ +Post-radiochemotherapy (total reference dose: 66.0 Gy) until <2005> for CUP syndrome (Tx pN2c). Tumor-suspected area in the area of the left edge of the tongue as part of the tumor follow-up. Biopsy was performed externally. Pathohistolog. Presence of a keratinizing squamous cell carcinoma. There is now an indication for panendoscopy and excision biopsy of the tongue margin tumor on the left side. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/603/icd_codes.txt b/603/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bd499c58a417cfc54de3fb3d79d05e5befa06940 --- /dev/null +++ b/603/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 ] \ No newline at end of file diff --git a/603/ops_codes.txt b/603/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..91881f93bf43370129df053be1247d9dbee9f4a6 --- /dev/null +++ b/603/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Diagnostische Ösophagogastroskopie[1-631 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Endoskopische Biopsie Ösophagus [1-5 Biopsien][1-440.a ] Biopsie ohne Inzision Larynx sonstige Lokalisation[1-421.x ] Biopsie an der Zunge ohne Inzision[1-420.1 ] \ No newline at end of file diff --git a/603/patient_clinical_data.json b/603/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4e5e6a017996cab10632653cdce39200f957e136 --- /dev/null +++ b/603/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 58, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/603/patient_pathological_data.json b/603/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2dd660a3d54174696972c5053229884d3f35ebdf --- /dev/null +++ b/603/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "603", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/603/surgery_description.txt b/603/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ff3085ab1e5d8f9463a9357f914f8d69060e578 --- /dev/null +++ b/603/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Resection of tongue edge cancer, PE's (Esophagus, ZGru, Ary) diff --git a/603/surgery_report.txt b/603/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..58014e0d06816a7f19c1f0dcb51d69fe02b4a65c --- /dev/null +++ b/603/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, rigid tracheoscopy is performed by . This reveals inconspicuous mucosal conditions on all sides up to the tracheal bifurcation. Subsequent intubation of the patient by the anesthesia colleagues. Start of esophagogastroscopy. Insertion of the endoscope under visualization and constant air insufflation into the stomach. This reveals a slightly erosive gastric mucosa relief on all sides, but without any evidence of a tumor. Entering in inversion. Inspection of the gastro-oesophageal junction. Mucosal changes due to reflux can be seen here. After desufflation, slow withdrawal of the endoscope with circular inspection of the entire esophagus. Here, especially in the area of the distal and middle third, there are flat, uneven mucosal changes with whitish deposits, which can be partially scraped off. A thrush esophagitis can be considered in the differential diagnosis. However, to rule out malignancy, biopsies are taken from a total of 3 conspicuous, uneven areas. (44 cm, 34 and 30 cm from the alveolar ridge). Then proceed to pharyngo-laryngoscopy: insertion of the size B Kleinsasser tube and adjustment of the endolarynx. This also reveals uneven, postradiogenically altered mucosal conditions on all sides. In the area of the glottic plane there is Reinke's edema on both sides, right > left. Otherwise no evidence of a tumor. Adjustment of the posterior commissure. Here, too, there is no evidence of tumor growth. Only in the area of the left arytenoid hump is there an uneven change in the mucosa which is biopsied. Subsequently, the right and left piriform sinuses are entered. This can be freely unfolded and is lined with postradiogenically altered smooth mucosa up to the tip of the piriform sinus. Also inconspicuous mucosal conditions in the area of the esophageal entrance and postcricoid. Setting of the vallecula. Here, too, only postradiogenically altered mucosa without evidence of tumorous growth. In the area of the left base of the tongue, the mucosa is inspectably uneven and partially covered. Therefore biopsy in the area of the left base of the tongue. Hemostasis by means of monopolar coagulation. Otherwise unremarkable mucosal conditions in the rest of the oropharynx. Subsequent insertion of the reinforced retractors and looping of the tongue. The lesion described above is seen in the area of the left middle edge of the tongue with external histological suspicion of squamous cell carcinoma. Marking of the resection margins using the electric needle with a safety distance of at least 1 cm on all sides. Then resection of the area with the monopolar needle. Resection of the ulcer using the scissors. Hemostasis using bipolar coagulation. Suture marking is still performed in situ (ventral suture marking long long, inferior suture marking short short). Hemostasis using bipolar coagulation. Clinically macroscopically, a wide in sano resection of the ulcer was performed. After consultation with , the tumor resected in toto for definitive histology. Subsequent completion of the operation without complications. Conclusion: Clinical macroscopic in sano resection of a left tongue marginal ulcer with externally histologically expressed suspicion of squamous cell carcinoma. Furthermore, multiple biopsies in the area of the esophagus with extensive changes in the mucosa. A thrush esophagitis can also be considered in the differential diagnosis. If malignancy in the area of the esophagus is excluded, a gastroenterological evaluation and treatment should be initiated. Further procedure after receipt of the definitive histology. \ No newline at end of file diff --git a/604/InvasionFront_CD3_block13_x5_y3_patient604_0.json b/604/InvasionFront_CD3_block13_x5_y3_patient604_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1ceb62ea8349348f6c6f5330bfd51490f21b0805 --- /dev/null +++ b/604/InvasionFront_CD3_block13_x5_y3_patient604_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 6896.3, + "Num Detections": 19682, + "Num Negative": 19536, + "Num Positive": 146, + "Positive %": 0.7418, + "Num Positive per mm^2": 62.55 + } +} \ No newline at end of file diff --git a/604/InvasionFront_CD3_block13_x6_y3_patient604_1.json b/604/InvasionFront_CD3_block13_x6_y3_patient604_1.json new file mode 100644 index 0000000000000000000000000000000000000000..34fd0a436f76f21a79dbe6129879a671e2ec71b9 --- /dev/null +++ b/604/InvasionFront_CD3_block13_x6_y3_patient604_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 6896.3, + "Num Detections": 18368, + "Num Negative": 18212, + "Num Positive": 156, + "Positive %": 0.8493, + "Num Positive per mm^2": 66.56 + } +} \ No newline at end of file diff --git a/604/InvasionFront_CD8_block13_x5_y3_patient604_0.json b/604/InvasionFront_CD8_block13_x5_y3_patient604_0.json new file mode 100644 index 0000000000000000000000000000000000000000..654aa631359e3c482151d2b8d2b16df8fa317621 --- /dev/null +++ b/604/InvasionFront_CD8_block13_x5_y3_patient604_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17540.7, + "Centroid Y µm": 8745.4, + "Num Detections": 21583, + "Num Negative": 21259, + "Num Positive": 324, + "Positive %": 1.501, + "Num Positive per mm^2": 131.8 + } +} \ No newline at end of file diff --git a/604/InvasionFront_CD8_block13_x6_y3_patient604_1.json b/604/InvasionFront_CD8_block13_x6_y3_patient604_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ebaf8205a80d304280612e828cb1e4440922022 --- /dev/null +++ b/604/InvasionFront_CD8_block13_x6_y3_patient604_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20139.3, + "Centroid Y µm": 8820.3, + "Num Detections": 19695, + "Num Negative": 19384, + "Num Positive": 311, + "Positive %": 1.579, + "Num Positive per mm^2": 125.89 + } +} \ No newline at end of file diff --git a/604/TumorCenter_CD3_block13_x5_y3_patient604_0.json b/604/TumorCenter_CD3_block13_x5_y3_patient604_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f49848b4397516ab9c826f47e1d4de783b70b2c2 --- /dev/null +++ b/604/TumorCenter_CD3_block13_x5_y3_patient604_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17540.7, + "Centroid Y µm": 14292.4, + "Num Detections": 20003, + "Num Negative": 18933, + "Num Positive": 1070, + "Positive %": 5.349, + "Num Positive per mm^2": 438.16 + } +} \ No newline at end of file diff --git a/604/TumorCenter_CD3_block13_x6_y3_patient604_1.json b/604/TumorCenter_CD3_block13_x6_y3_patient604_1.json new file mode 100644 index 0000000000000000000000000000000000000000..244c56bac67b5bcaee5e87f6ffddc1c216f4214a --- /dev/null +++ b/604/TumorCenter_CD3_block13_x6_y3_patient604_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 14442.4, + "Num Detections": 20450, + "Num Negative": 19509, + "Num Positive": 941, + "Positive %": 4.601, + "Num Positive per mm^2": 388.36 + } +} \ No newline at end of file diff --git a/604/TumorCenter_CD8_block13_x5_y3_patient604_0.json b/604/TumorCenter_CD8_block13_x5_y3_patient604_0.json new file mode 100644 index 0000000000000000000000000000000000000000..baacd1169ef8af37d8ab9bf06cc77c2bce32285f --- /dev/null +++ b/604/TumorCenter_CD8_block13_x5_y3_patient604_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 7421.1, + "Num Detections": 20139, + "Num Negative": 18936, + "Num Positive": 1203, + "Positive %": 5.973, + "Num Positive per mm^2": 497.15 + } +} \ No newline at end of file diff --git a/604/TumorCenter_CD8_block13_x6_y3_patient604_1.json b/604/TumorCenter_CD8_block13_x6_y3_patient604_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3e04f4cf6e483ec7d7147ceabce0416abbe0853 --- /dev/null +++ b/604/TumorCenter_CD8_block13_x6_y3_patient604_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18190.4, + "Centroid Y µm": 7096.2, + "Num Detections": 17989, + "Num Negative": 16508, + "Num Positive": 1481, + "Positive %": 8.233, + "Num Positive per mm^2": 622.85 + } +} \ No newline at end of file diff --git a/604/history_text.txt b/604/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..74507a44974218abc4686de21a0c7225ed114402 --- /dev/null +++ b/604/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma with herniation into the laryngeal skeleton. cT4 cN2b status in sonogram and CT. Therefore above mentioned surgery indicated. \ No newline at end of file diff --git a/604/icd_codes.txt b/604/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab23043e55b760438aecd97235569cd1f5972154 --- /dev/null +++ b/604/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Kehlkopfknorpelkarzinom[C32.3 ] \ No newline at end of file diff --git a/604/ops_codes.txt b/604/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bb72ca3046f035b5b639a025f626666cbe613f12 --- /dev/null +++ b/604/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Pharyngektomie[5-303.1x ] Transplantat[5-295.14 ] Entnahme freier Radialis-Lappen[5-858.23 L] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Permanente Tracheotomie[5-312.0 ] Entnahme von Spalthaut am Oberschenkel[5-901.0e R] Freie Lappenplastik am Hals mit mikrovaskulärer Anastomosierung[5-905.05 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/604/patient_clinical_data.json b/604/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ffe50a63200e454f8a6de8239348d99b54f18cb6 --- /dev/null +++ b/604/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 44, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/604/patient_pathological_data.json b/604/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dc88d5445d40821a15a79401d7f325b0e1d9e7b5 --- /dev/null +++ b/604/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "604", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/604/surgery_description.txt b/604/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f8ad13e7bcab38f1299ee38e743969b8990b5fcb --- /dev/null +++ b/604/surgery_description.txt @@ -0,0 +1 @@ +LE with partial pharyngectomy, Modified radical neck dissection Level II-V, Free flap (Radial), Tracheotomy diff --git a/604/surgery_report.txt b/604/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..83ab749ed38a6853ebca16ae67ab08c6c6939883 --- /dev/null +++ b/604/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia by the anesthetist. Then bronchoscopic intubation by the anesthetist. This is very difficult as the large tumor masses almost completely obstruct the glottic plane. Ultimately, the patient can be intubated transnasally by bronchoscopy. Then we enter with the Kleinsasser tube and inspect the hypopharyngeal and laryngeal areas. Another detailed inspection of the tumor. As already described, the tumor begins at the lower tonsil pole, moves down the lateral pharyngeal wall and infiltrates the lateral and medial wall of the piriform sinus. However, the tip of the piriform sinus is free. Then infiltration of the postcricoid region and the pocket fold region in the right laryngeal region. Then placement of a feeding tube and sterile washing and draping. Start with the creation of an apron flap in the usual manner. Then perform a modified radical neck dissection on the right side. Exposure of the sternocleidomastoid muscle, the submandibular gland and the omohyoid muscle. Locating the accessorius nerve. This is difficult, as there are several large metastases in the area of level II a and b, which are first carefully detached. These can be dissected away from the jugular vein although they are directly attached to it. Dissection of the entire internal jugular vein. Removal of the remaining level II a and b. Levels III, IV and V are still covered with hard, rough metastases. These metastases are also located between the plexus branches and some plexus branches unfortunately have to be sacrificed in order to cleanly remove the metastases. The vagus nerve and border cord can be spared. The metastases themselves are directly adjacent to the internal and common carotid arteries, but can be easily dissected away from them. Then perform neck dissection level VI. Release the hyoid bone from the left side. Dissect the cervical vascular sheath on the right side of the larynx and hypopharynx. Skeletonization of the larynx. Separation of the entire laryngeal musculature. Exposure of the pharynx directly above the hyoid. Performing a pharyngotomy and extracting the epiglottis. Clamping of the epiglottis and cutting around the tumor with a sufficient safety distance, taking the hyoid bone with it. In the area of the pharyngeal side wall on the right, the tumor is resected, but with a very small safety margin, so a marginal sample is immediately taken again and sent for a frozen section. Fortunately, no tumor cells, no carcinoma in situ or higher-grade dysplasia. Further exploration of the larynx along the postcricoid region. First release of the thyroid gland and free preparation of the trachea. Entering the trachea and performing a tracheotomy. Performing a mucocutaneous anastomosis in the lower region. Re-intubation. Then return to the laryngeal preparation. The larynx is completely released along the postcricoid region and the cricoid cartilage. Separation of the larynx from the posterior wall of the trachea. The posterior wall of the trachea is cut upwards like a flap. The entire laryngeal preparation is sent to the frozen section marked with a suture. The pathologist is unable to detect carcinoma in situ, inverse carcinoma or high-grade dysplasia at the edges. Now the myotomy is performed. For this, the esophageal entrance and the esophagus are opened digitally and the constrictor muscles are cut with sharp scissors so that ultimately only the mucosa remains. The myotomy is performed posteromedially as usual. The lower attachments of the sternocleidomastoid muscle are then incised to create a flatter stoma. This is performed on both sides using the monopolar knife. After securing the R0 resection, elevation of the left forearm flap. Marking of the flap in a size of approx. 9 x 6 cm. Marking of a skin monitor. Subsequent resection of the flap from the ulnar side. Preparation of a subcutaneous bridge to the skin monitor on both sides. The incision is extended to the crook of the elbow. Then locate the superficial venous system. Integration into the subcutaneous bridge to the skin monitor. The flap is then lifted from the lateral side. Exposure of the lateral antebrachial cutaneous nerve. Distal clamping of the radial artery. Saturation always at 98 to 100 %. After approx. 15 minutes with good saturation, the artery is removed. This is ligated proximally distally with 4-0 Prolene. Then lift the flap subfascially. Smaller vessels are coagulated bipolar or treated with clips. Exposure and connection between the superficial and deep venous system in the antecubital region. Exposure of the radial artery. Clamping of the interosseous artery. If good saturation is maintained, closure of the. Interosseous artery using clips. Two good venous outlets from the cephalic vein can be visualized. Removal of the flap. Veins are ligated. The artery is closed in the entry area into the brachial artery using 6-0 Vascufil sutures. Then flush the flap with Ringer's solution. Before insertion of the flap, a left myotomy is performed in the typical manner. Complete transection of the muscle fibers. Esophageal wall is opened slightly distally at the entrance area to ensure greater passage. Provox prosthesis cannot be used primarily due to the overall situation. Flap is successively incorporated into the defect with 3-0 Vicryl single-button sutures. Tension-free closure. Stem is placed to the right. Conditioning of the radial artery and the superior thyroid artery. Suture with 8-0 Ethilon single-button sutures. Opening of the clamp, good arterial flow, good venous return. Two branches of the cephalic vein are selected for the anastomosis. The radial vein is clipped. One end of the cephalic vein is easily clipped to an outlet of the facial vein after selecting a 3-0 coupler. After opening the clamp, good venous return, positive smear phenomenon. The other part of the cephalic vein is coupled with the external jugular vein using a 3-0 coupler; here too, good venous return after opening the clamp, positive smear phenomenon. Subsequent careful irrigation of the wound area. Hemostasis. Wound closure in layers and placement of a Redon drain on each side, epithelialization of the tracheostoma and insertion of the skin monitor via a small transverse skin incision at the upper edge of the right apron incision. A 10 mm tracheostomy tube is then inserted and secured with sutures. In the thigh area, a piece of 0.8 mm split skin is removed in the corresponding size of the defect. Hydrogel dressing is applied to the thigh area. The forearm is primarily closed in the cranial area. In the caudal area, the defect is covered by suturing the removed split skin. Hydrogel-Mepilex dressing is then applied. Loose compresses are applied on top. Wrapping with absorbent cotton. Fitting of a Cramer splint in functional position. Wrap with elastic bandage. Arm always well saturated until the end. Completion of the procedure without complications. Patient goes to intensive care unit for postoperative monitoring. Insertion of Redon drains, one per side. Fixation of the Redon drain on the inside of the anastomosis, otherwise on the outside as usual. Two-layer wound closure and completion of the mucocutaneous anastomosis in the tracheostoma area. Insertion of a tracheal cannula. Fixation by suturing the tracheostomy tube and completion of the procedure without complications. Please continue antibiotics, which were started intraoperatively with Unacid, for at least 2-3 days. Feeding via the PEG tube that was placed during the last operation for at least 10 days, then gruel and, if necessary, diet build-up. Flap control via skin monitoring or using a Doppler probe for 5 days. Continue heparin perfusor 500 E/hour for 5 days. Total cT4 cN2b hypopharyngeal carcinoma with invasion of the right laryngeal skeleton. Discuss postoperative adjuvant radiotherapy versus radiochemotherapy according to the histologic findings. \ No newline at end of file diff --git a/605/InvasionFront_CD8_block5_x1_y11_patient605_0.json b/605/InvasionFront_CD8_block5_x1_y11_patient605_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f09ab3fadfa6b72d8711e7e6cae8140b2cb0b6ad --- /dev/null +++ b/605/InvasionFront_CD8_block5_x1_y11_patient605_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 27635.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/605/InvasionFront_CD8_block5_x2_y11_patient605_1.json b/605/InvasionFront_CD8_block5_x2_y11_patient605_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0b7a8bfec6b5654895b99168bf08b84aef2fb468 --- /dev/null +++ b/605/InvasionFront_CD8_block5_x2_y11_patient605_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 27610.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/605/TumorCenter_CD3_block5_x1_y11_patient605_0.json b/605/TumorCenter_CD3_block5_x1_y11_patient605_0.json new file mode 100644 index 0000000000000000000000000000000000000000..76e83089d338d1468866280fea29b7cc5f87134f --- /dev/null +++ b/605/TumorCenter_CD3_block5_x1_y11_patient605_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 26710.9, + "Num Detections": 15103, + "Num Negative": 12373, + "Num Positive": 2730, + "Positive %": 18.08, + "Num Positive per mm^2": 1364.1 + } +} \ No newline at end of file diff --git a/605/TumorCenter_CD3_block5_x2_y11_patient605_1.json b/605/TumorCenter_CD3_block5_x2_y11_patient605_1.json new file mode 100644 index 0000000000000000000000000000000000000000..093a2c23cfa68f0e427844c94f7c0e611075cddf --- /dev/null +++ b/605/TumorCenter_CD3_block5_x2_y11_patient605_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 26860.8, + "Num Detections": 17730, + "Num Negative": 13842, + "Num Positive": 3888, + "Positive %": 21.93, + "Num Positive per mm^2": 1742.1 + } +} \ No newline at end of file diff --git a/605/TumorCenter_CD8_block5_x1_y11_patient605_0.json b/605/TumorCenter_CD8_block5_x1_y11_patient605_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6d7c2e2e9758bb676d72cb62f971e92c9bf8aff --- /dev/null +++ b/605/TumorCenter_CD8_block5_x1_y11_patient605_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 27760.3, + "Num Detections": 16323, + "Num Negative": 15472, + "Num Positive": 851, + "Positive %": 5.214, + "Num Positive per mm^2": 420.04 + } +} \ No newline at end of file diff --git a/605/TumorCenter_CD8_block5_x2_y11_patient605_1.json b/605/TumorCenter_CD8_block5_x2_y11_patient605_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2da6146b29d6c3f3d3d380396318ed2b40527e1 --- /dev/null +++ b/605/TumorCenter_CD8_block5_x2_y11_patient605_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 27685.3, + "Num Detections": 17501, + "Num Negative": 15420, + "Num Positive": 2081, + "Positive %": 11.89, + "Num Positive per mm^2": 941.42 + } +} \ No newline at end of file diff --git a/605/history_text.txt b/605/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd390368880293e6c525f3113b6a2e1c1b2bb8b1 --- /dev/null +++ b/605/history_text.txt @@ -0,0 +1 @@ +The patient presents with an exophytic mass localized in the area of the lateral wall of the oropharynx, extending from the left tonsillar lobe to the anterior posterior palatal arch and infiltrating the soft palate. Furthermore, the tumor extends caudally along the lateral wall of the oropharynx and infiltrates the base of the tongue and extends to the vallecula. The vallecula itself is free. The epiglottis, hypopharynx and larynx are also free. Due to the location and size of the tumor, a decision was made to resect the tumor and cover the defect with a radialis graft. \ No newline at end of file diff --git a/605/icd_codes.txt b/605/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..901c2682d6245b9ff696def034883145da4b580b --- /dev/null +++ b/605/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/605/ops_codes.txt b/605/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45e2aa84b89140ad8fdb21faf12cba3ca7f3bfbf --- /dev/null +++ b/605/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] sonstige[5-296.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Permanente Tracheotomie[5-312.0 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 B] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Transplantat[5-295.04 ] \ No newline at end of file diff --git a/605/patient_clinical_data.json b/605/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5f19e8e427378b6edadbde6272baa42651855c09 --- /dev/null +++ b/605/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/605/patient_pathological_data.json b/605/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..02f2b5777402aab31f52057a1487ac538f5c4011 --- /dev/null +++ b/605/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "605", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/605/surgery_description.txt b/605/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f252d5aa78423dde50e696a14b4b2880b421dd7 --- /dev/null +++ b/605/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), Tracheotomy, PEG placement diff --git a/605/surgery_report.txt b/605/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a5d882a28e98e8ae6f342fdd84d5070b662b546 --- /dev/null +++ b/605/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and transnasal intubation by the anesthesia colleagues. First, tumor resection by : The exophytic tumor is seen, which is located in the area of the tonsillar lobe, extends over the glossoalveolar groove to the base of the tongue, also runs towards the soft palate, but does not quite reach the border of the posterior palatal arch; the tumor extends caudally to below the tonsillar lobe. Now insertion of retractors or McIvor oral flaps alternately and suturing of the tongue. The tumor is successively incised macroscopically with a safety margin of at least 1 to 1.5 cm. Resection covers the posterior palate, anterior palate, lowest parts of the buccal mucosa at the border to the alveolar ridge, further along or above the alveolar ridge in the anterior direction, then via the glossoalveolar groove into the base of the tongue. Dorsocaudally, the resection extends over the posterior palatal arch to the adjacent pharyngeal side wall and finally just in front of the hypopharynx towards the base of the tongue and floor of the mouth. The floor of the mouth is also resected in the dorsal parts. The lingual nerve is located in the resection area and is also resected, as are the dorsal parts of the sublingual gland. The uppermost parts of the submandibular gland are also included in the preparation. Craniobasally, the resection extends in depth to the styloid process, which is exposed and the tumor is successively resected, taking the entire pterygoid musculature with it. The carotid artery is still palpable under the styloid process or under a thin soft tissue sheath and is not directly exposed. Finally, the entire tumor is removed and suture-marked in a typical manner. A marginal sample is taken cranially from the soft palate to the border of the alveolar ridge and also thread-marked. In addition, a marginal sample is taken anteriorly, which is also thread-marked and extends from the edge of the tongue to the alveolar ridge along the floor of the mouth. In the frozen section, despite ample safety margins of 1 to 1.5 cm, there are still in situ infiltrates or moderate to high-grade dysplasia in the area of the palatal arch, base of the tongue and along the alveolar ridge. Therefore, another marginal sample is taken medially on the pharynx with suture markings, as well as a marginal sample from the palate to the alveolar ridge with markings remote from the tumor and a marginal sample from the tongue area medially including caudal to the base of the tongue, also with suture markings here. Also a marginal sample from the alveolar ridge anterior lateral. No evidence of higher-grade dysplasia or invasive carcinoma in the marginal samples taken. Similarly, no carcinoma in the marginal samples taken at the beginning, also no invasive carcinoma or higher-grade dysplasia. Therefore, surgical R0 resection, although there is a suspicion that there may be a tendency towards field cancerization. Then perform PEG placement through and using the suture pull-through method. This is easily possible with good diaphanoscopy. Then sterile washing and draping and initial removal of the left arm. Perform the neck dissection on the right side through and . To do this, incise the skin in the usual way. Expose the borders. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Showing the digastric muscle. Showing the cervical vascular sheath. Showing the hypoglossal and accessorius nerve. Exposure of the cervical sinus. Clearing of the neck levels IIa to Va while sparing the plexus branches. Insertion of a Redon drainage and two-layer wound closure. Then tracheotomy performed by . For this, vertical skin incision, exposure of the pretracheal musculature. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Creation of a visor tracheotomy between the 2nd and 3rd tracheal cartilage. Creation of a mucocutaneous anastomosis. Then neck dissection on the left side by . Incision in the usual manner. Exposure of the sternocleidomastoid muscle, exposure of the submandibular gland. Exposure of the cervical vascular sheath and the omohyoid muscle. Exposure of the accessorius nerve and hypoglossus. Clearing of neck levels IIa to Va while sparing the plexus branches. Then removal of the submandibular gland on the left side, which was already partially resected during the tumor resection and creation of a 3 QF wide tunnel to the inside of the mouth. Parallel to this, lift the radialis graft from the left by and : mark the flap in the appropriate size and three-dimensional configuration, also in the direction of the pedicle. Then first lift the radial flap from the ulnar side and extend the incision cranially. Identification of the superficial venous system and the deep flap pedicle. Then recut the flap also from the radial side. This is done under constant pulse oximeter control, no special features here. The flap is also perfused. Then locate the pedicle. Deposition of the pedicle. This is treated distally and cranially with 4-0 Prolene puncture ligatures. The flap is then lifted along the pedicle in the typical manner, the outgoing vessels or outgoing vessels from the musculature are clipped successively. Dissection of the pedicle up to the crook of the elbow. Here the cephalic vein with 2 good outlets as well as a good confluence and the radial artery can be dissected. It can be seen that the radial artery graft is no longer perfused. Then puncture in the skin area. There is no blood flow and no detectable pulse signal in the area of the flap by Doppler sonography, only the proximal 2/3 of the flap stalk is still detectably perfused by Doppler sonography. The flap is then immediately warmed with warm cloths. As the flap still showed good perfusion in the proximal pedicle area, the decision was made to anastomose it arterially at the neck. Now anastomosis between the radial artery and the superior thyroid artery through . The thyroid artery showed very good blood flow. Unfortunately, even now there was no graft perfusion and there was also no vernal return flow. Especially spasm of the flap. As a last resort, the flap was placed in a solution of lidocaine, sodium bicarbonate and nitroglycerin and later sprayed again with nitrospray. When these measures proved ineffective, the decision was made to remove the flap and perform an endoscopy of the radial artery with a 0.8 mm endoscope from proximal and distal. Overall unclear situation. Explanation by the scar described by the patient, which was described as a superficial injury, not sufficient. Filiform openings are found at the upper entrance to the flap. In this case, anomaly of the vessel or consequence of an injury. A major trauma is not known from the anamnesis and was not described by the patient when asked. Nonetheless, there is evidence of insufficient flap perfusion at the upper border of the flap or at the upper edge of the flap where the artery enters. At the site of the filiform vascular drawings, the artery is now dissected out in the fatty tissue. It can also be seen here that the artery is lost in filiform, smaller vessel lumina. This means that the blood supply to the flap in this region is interrupted. The forearm is closed in a typical manner using split skin from the right thigh. Due to the defect, the only remaining option is to elevate the radial flap on the opposite side in order to cover the defect in an adequate, three-dimensional and areal dimension. Therefore, after covering the right side of the arm, lift the radialis flap from the right: Here too, after marking the flap, proceed in the same way as on the opposite side. As on the opposite side, a superficial venous system and the connection to the deep venous system as well as the deep vascular system of the flap pedicle can be visualized. Here too, first dissection from the ulnar, then from the radial side. Here too, the lateral antebrachial cutaneous nerve is preserved as on the opposite side. Separation of the flap distally with puncture ligation, as on the opposite side, and dissection cranially with supply of the outgoing vessels using clips or bipolar or ligature. At the end, 2 cephalic veins and a good radial artery. After removal of the flap, the veins are supplied with ligatures. The artery is supplied via puncture ligatures. Blood flow to the hand is always very good until the end with saturation values of 99 to 100 %. Very good blood supply to the flap. Ample irrigation of the flap pedicle with heparin solution. No special features here either. Subsequent closure of the forearm with split skin from the right thigh. The graft from the right side is regularly perfused and completely unremarkable. The graft is then removed, rinsed with heparin and prepared for insertion into the oropharynx. The tunnel must be widened slightly for this, as there is not yet sufficient visibility from the transcervical side into the defect. Suturing is almost impossible as the tongue and cheek area are extremely swollen and the patient already has a very small mouth opening. Therefore, the graft is first sutured to the soft palate and to the lateral wall of the oropharynx from the transoral side and the rest from the transcervical side in the area of the medial pharyngeal wall and around the base of the tongue. Then turn the graft over and suture in the area of the alveolar ridge and the floor of the mouth again from the transoral side. Then prepare the facial artery to attach the graft, which had already been ligated beforehand. The flow is very good. Anastomosis with the facial artery and a stump of the internal jugular vein to the deep flap vein and then anastomosis between the facial artery stump and the cephalic vein. Positioning of the pedicle. Fixation of the pedicle with Gelita. Insertion of a Penrose drain and two-layer wound closure, completion of the procedure. The patient is ventilated and admitted to the intensive care unit. Please continue antibiotics for at least 24 hours. Wait for histology and presentation of the patient at the tumor conference. A blue swallow can be performed clinically from the 10th postoperative day. An X-ray pre-swallow is not necessary. \ No newline at end of file diff --git a/606/InvasionFront_CD3_block1_x3_y10_patient606_0.json b/606/InvasionFront_CD3_block1_x3_y10_patient606_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6635cfdac7986eb6f97db8504fffd06be8257b84 --- /dev/null +++ b/606/InvasionFront_CD3_block1_x3_y10_patient606_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 26585.9, + "Num Detections": 17848, + "Num Negative": 17604, + "Num Positive": 244, + "Positive %": 1.367, + "Num Positive per mm^2": 118.48 + } +} \ No newline at end of file diff --git a/606/InvasionFront_CD3_block1_x4_y10_patient606_1.json b/606/InvasionFront_CD3_block1_x4_y10_patient606_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd509dc941ec0d3498849933e356cbe404614b26 --- /dev/null +++ b/606/InvasionFront_CD3_block1_x4_y10_patient606_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 26785.8, + "Num Detections": 19476, + "Num Negative": 18647, + "Num Positive": 829, + "Positive %": 4.257, + "Num Positive per mm^2": 349.54 + } +} \ No newline at end of file diff --git a/606/InvasionFront_CD8_block1_x3_y10_patient606_0.json b/606/InvasionFront_CD8_block1_x3_y10_patient606_0.json new file mode 100644 index 0000000000000000000000000000000000000000..35b8446557e1ac59078201619e3aa82390ac45e4 --- /dev/null +++ b/606/InvasionFront_CD8_block1_x3_y10_patient606_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 25286.6, + "Num Detections": 17219, + "Num Negative": 17077, + "Num Positive": 142, + "Positive %": 0.8247, + "Num Positive per mm^2": 72.83 + } +} \ No newline at end of file diff --git a/606/InvasionFront_CD8_block1_x4_y10_patient606_1.json b/606/InvasionFront_CD8_block1_x4_y10_patient606_1.json new file mode 100644 index 0000000000000000000000000000000000000000..84450dddff917c5e5e00c56d29a1b67103fc4dbc --- /dev/null +++ b/606/InvasionFront_CD8_block1_x4_y10_patient606_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13631.9, + "Centroid Y µm": 25255.0, + "Num Detections": 18512, + "Num Negative": 17670, + "Num Positive": 842, + "Positive %": 4.548, + "Num Positive per mm^2": 366.18 + } +} \ No newline at end of file diff --git a/606/TumorCenter_CD3_block1_x3_y12_patient606_0.json b/606/TumorCenter_CD3_block1_x3_y12_patient606_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e7d151f01a4ab5b8e7834b1c8f40dbbeab2ae2c6 --- /dev/null +++ b/606/TumorCenter_CD3_block1_x3_y12_patient606_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 29859.2, + "Num Detections": 16524, + "Num Negative": 11479, + "Num Positive": 5045, + "Positive %": 30.53, + "Num Positive per mm^2": 2652.0 + } +} \ No newline at end of file diff --git a/606/TumorCenter_CD3_block1_x4_y12_patient606_1.json b/606/TumorCenter_CD3_block1_x4_y12_patient606_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fa1660bf2ee37419997c72cb76edb86592456331 --- /dev/null +++ b/606/TumorCenter_CD3_block1_x4_y12_patient606_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 29759.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/606/TumorCenter_CD8_block1_x3_y10_patient606_0.json b/606/TumorCenter_CD8_block1_x3_y10_patient606_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0bd4d2bc1be26126627feb883aa1b07b593dbe1b --- /dev/null +++ b/606/TumorCenter_CD8_block1_x3_y10_patient606_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 33707.2, + "Num Detections": 26684, + "Num Negative": 23920, + "Num Positive": 2764, + "Positive %": 10.36, + "Num Positive per mm^2": 981.42 + } +} \ No newline at end of file diff --git a/606/TumorCenter_CD8_block1_x4_y10_patient606_1.json b/606/TumorCenter_CD8_block1_x4_y10_patient606_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8cfbfb2348881692660ee0c67cd6f0fdcf2eaa2b --- /dev/null +++ b/606/TumorCenter_CD8_block1_x4_y10_patient606_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 33907.0, + "Num Detections": 16941, + "Num Negative": 16625, + "Num Positive": 316, + "Positive %": 1.865, + "Num Positive per mm^2": 175.35 + } +} \ No newline at end of file diff --git a/606/history_text.txt b/606/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..59f6f83fdfde98931607b60c33b320118bc7a7eb --- /dev/null +++ b/606/history_text.txt @@ -0,0 +1 @@ +The patient underwent resection of a pT1 pN0 oral floor carcinoma in 2011. No adjuvant therapy was given. Now suspected hypopharyngeal carcinoma on the left with suspicious lymph nodes on the left side of the neck. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/606/icd_codes.txt b/606/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5212b2449e4c0ff913cf22c77528d0893535be0b --- /dev/null +++ b/606/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Aryepiglottische Falte, hypopharyngeale Seite[C13.1 ] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] Kehlkopfzyste[J38.7 ] \ No newline at end of file diff --git a/606/ops_codes.txt b/606/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9cc97e135005147d5653009493b65c11da2fcb0a --- /dev/null +++ b/606/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-296.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 1 Region[5-403.00 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Spalthautdeckung großflächig Empfängerstelle Hand[5-902.49 L] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Marsupialisation Larynxzyste endoskopisch[5-300.x ] \ No newline at end of file diff --git a/606/patient_clinical_data.json b/606/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e2ab477a5bfd82595c8eb4b7123974e1cda53891 --- /dev/null +++ b/606/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 73, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/606/patient_pathological_data.json b/606/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2b8389c9502acf2842506a7e06349aea11879a9c --- /dev/null +++ b/606/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "606", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/606/surgery_description.txt b/606/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..22810dd81209599a9c5d3f506bfd7eb7f2d3747b --- /dev/null +++ b/606/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, PEG placement, Free flap (Radial) diff --git a/606/surgery_report.txt b/606/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce92b7708571a35cda2c752ce6a94c739d9b268c --- /dev/null +++ b/606/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, a tracheostomy is performed first. Initial sterile washing and draping of the neck area. Marking of the skin incision for the tracheotomy, where the apron flap will later be made. Skin incision, then exposure of the infrahyoid muscles. Pushing aside the infrahyoid musculature. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Exposure of the anterior wall of the trachea and insertion between the 2nd and 3rd tracheal cartilage and creation of a visor tracheotomy. Then insertion with the small bore tube and inspection of the hypopharyngeal and laryngeal area. On the left side of the hypopharynx at the entrance to the piriform sinus on the lateral and anterior wall, an exophytic, coarse mass can be seen. This mass is not easy to move and infiltrates the entire pharyngeal wall. Laser resection is therefore not possible. Then sterile washing and draping and creation of an apron flap in the usual manner. Then work in parallel with neck dissection on the right and neck dissection on the left. Neck dissection on the left by : Incision of the skin and subcutaneous fatty tissue in a skin fold on the anterior edge of the sternocleidomastoid muscle at least 2 transverse fingers below the lower jaw. Separation of the platysma and identification of the sternocleidomastoid muscle. In the case of previous surgery (neck dissection), extremely scarred conditions with difficult dissection and identification of the surrounding structures. Identification of the internal jugular vein. This is firmly fused to the sternocleidomastoid muscle and can be separated from the muscle with careful dissection. Identification of the common carotid artery and the vagus nerve. Identification of the carotid bifurcation and visualization of the superior thyroid artery and the facial artery. Identification of the accessor nerve in a scar bed and release of the nerve. Dissection down to the deep cervical fascia and the cervical plexus. The mass in level V described in the ultrasound and CT can be identified in depth and is removed. Completion of the neck dissection/node picking without complications. Neck dissection on the right by . Dissection of the sternocleidomastoid muscle and the omohyoid and digastric muscles. Exposure of the cervical vascular sheath. In very heavily scarred conditions, the internal jugular vein is torn several times. However, this can be sutured again with Vascufil 6-0 so that the blood flow is completely preserved. The accessorius nerve and hypoglossal nerve are then exposed and isolated lymph nodes and fatty material are removed. However, the neck is largely free of lymph nodes and fatty tissue due to the previous operation, so that no really large neck preparation remains. Then dissection of the facial vein, which has several outlets, and dissection of the superior thyroid artery as the arterial connecting vessel. Then lifting of the radialis graft by and parallel to the tumor resection. Tumor resection through on the left side. For this purpose, the small bore tube is again inserted into the pharynx via the mouth and the height of the pharyngotomy is determined. Start with the pharyngotomy on the lateral side of the pharynx on the left. Exposure of the tumor. Then cut around the tumor with a safety margin of 1.5 cm. As it is not certain whether the tumor will infiltrate the thyroid cartilage towards the basal edge, part of the thyroid cartilage is resected at the same site. The tumor is placed completely on cork and a frozen section is made. The frozen section shows that all edges are tumor-free. Then measurement of the defect and suturing of the graft by . Elevation of the radial forearm flap on the left by : Palpatory identification of the distal radial artery. Marking of the flap borders (6 x 11 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Covering of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. After removal of the radial flap, it is flushed with heparin. Vascular preparation of the cervical right side. The facial vein can be dissected as a venous connecting vessel, and the external jugular vein can also be used. The superior thyroid artery is selected as the arterial connecting vessel. First insert the flap into the defect and suture it in successively using 3-0 Vicryl single-button sutures. This is achieved with little tension and in an anatomically correct manner. The pedicle is now passed over the soft tissue to the opposite side on the right. The facial vein is then placed as cranially as possible and ligated cranially. Then also clamp the superior thyroid artery. This is double-clipped distally and removed and flushed with heparin, as is the facial vein. Conditioning of the superior thyroid artery and the radial artery. Subsequent suture or anastomosis with 9-0 Ethilon single-button sutures. Here, after opening the clamp, good arterial flow and good venous return. Then conditioning of the veins. The confluence shows very good venous return and is selected for the anastomosis with the facial vein. After conditioning the vein, the anastomosis is created using a 3-coupler. After opening the clamps, good venous return, positive smear phenomenon. The slightly longer cephalic vein, which is also thinner, should be anastomosed with the external jugular vein. To do this, the external jugular vein must be dissected further caudally and mobilized until it enters the deeper venous systems. It is then passed under the sternocleidomastoid muscle, which is partially severed at the corresponding point and thus thinned out to avoid compression. The vein can then be passed through the internal jugular vein without any problems. Anastomosis with the cephalic vein is now possible without tension. This is done after conditioning the veins with 2.0 Coupler. After opening the clamps, there is also good venous return, positive smear phenomenon. Another smaller venous outlet in the pedicle area is then clipped. Extensive irrigation of the wound area, careful hemostasis. The apron flap is then fixed to the upper edge of the tracheostoma with Ethilon sutures. The skin monitor, which now runs underneath the apron flap, is marked at its position, incision is made at exactly this point from the outside through the skin and the skin monitor is passed through. This is then loosely fixed with 5-0 Ethilon single button sutures. Good blood circulation here. Then successive closure of the wound on both sides, on the right with insertion of a Redon drainage, on the left with insertion of 2 flaps and epithelialization of the tracheostoma. An 8-gauge tracheostomy tube was then inserted and secured with sutures. On final inspection, the skin monitor is well perfused. The procedure is completed without complications. The patient is ventilated and admitted to the intensive care unit. Postoperative continuation of antibiotics with Unacid for 1 week. Feeding via the inserted PEG tube for at least 10 days, then gruel swallowing and, if necessary, diet build-up or presentation to the voice and speech department to initiate swallowing rehabilitation. Checking the blood circulation of the skin monitor or flap incl. Doppler control according to the scheme for 5 days. Continuation of therapy with Clexane at a dose of 0.6. Further procedure after receipt of the final histology, then presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/607/InvasionFront_CD3_block9_x1_y6_patient607_0.json b/607/InvasionFront_CD3_block9_x1_y6_patient607_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e055bf46c186379ef7d5b38987c00c675a2760e3 --- /dev/null +++ b/607/InvasionFront_CD3_block9_x1_y6_patient607_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5197.2, + "Centroid Y µm": 15067.0, + "Num Detections": 17137, + "Num Negative": 16491, + "Num Positive": 646, + "Positive %": 3.77, + "Num Positive per mm^2": 306.17 + } +} \ No newline at end of file diff --git a/607/InvasionFront_CD3_block9_x2_y6_patient607_1.json b/607/InvasionFront_CD3_block9_x2_y6_patient607_1.json new file mode 100644 index 0000000000000000000000000000000000000000..428e82b6bed4b33daa794d46bc995a87cdbced4c --- /dev/null +++ b/607/InvasionFront_CD3_block9_x2_y6_patient607_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7920.8, + "Centroid Y µm": 15341.9, + "Num Detections": 16320, + "Num Negative": 15997, + "Num Positive": 323, + "Positive %": 1.979, + "Num Positive per mm^2": 146.76 + } +} \ No newline at end of file diff --git a/607/InvasionFront_CD8_block9_x1_y6_patient607_0.json b/607/InvasionFront_CD8_block9_x1_y6_patient607_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ae815a928aa267dd5817f39abc7b952b1a90128f --- /dev/null +++ b/607/InvasionFront_CD8_block9_x1_y6_patient607_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5122.3, + "Centroid Y µm": 19164.9, + "Num Detections": 16169, + "Num Negative": 15809, + "Num Positive": 360, + "Positive %": 2.226, + "Num Positive per mm^2": 181.13 + } +} \ No newline at end of file diff --git a/607/InvasionFront_CD8_block9_x2_y6_patient607_1.json b/607/InvasionFront_CD8_block9_x2_y6_patient607_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8b504c6a64324181e0e3eefe9a0326444180138f --- /dev/null +++ b/607/InvasionFront_CD8_block9_x2_y6_patient607_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7795.9, + "Centroid Y µm": 19439.7, + "Num Detections": 18213, + "Num Negative": 17820, + "Num Positive": 393, + "Positive %": 2.158, + "Num Positive per mm^2": 171.15 + } +} \ No newline at end of file diff --git a/607/TumorCenter_CD3_block9_x1_y6_patient607_0.json b/607/TumorCenter_CD3_block9_x1_y6_patient607_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a8c1f8bb3b0aa180d9df16e8c02b5681ba33ef14 --- /dev/null +++ b/607/TumorCenter_CD3_block9_x1_y6_patient607_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3947.9, + "Centroid Y µm": 20464.2, + "Num Detections": 15780, + "Num Negative": 15673, + "Num Positive": 107, + "Positive %": 0.6781, + "Num Positive per mm^2": 46.38 + } +} \ No newline at end of file diff --git a/607/TumorCenter_CD3_block9_x2_y6_patient607_1.json b/607/TumorCenter_CD3_block9_x2_y6_patient607_1.json new file mode 100644 index 0000000000000000000000000000000000000000..afcd95fa1f62db991396e856e53738b5eec54053 --- /dev/null +++ b/607/TumorCenter_CD3_block9_x2_y6_patient607_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 20539.1, + "Num Detections": 14333, + "Num Negative": 14074, + "Num Positive": 259, + "Positive %": 1.807, + "Num Positive per mm^2": 111.42 + } +} \ No newline at end of file diff --git a/607/TumorCenter_CD8_block9_x1_y6_patient607_0.json b/607/TumorCenter_CD8_block9_x1_y6_patient607_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8819c868318922b6840ab73167817e6750ae71ea --- /dev/null +++ b/607/TumorCenter_CD8_block9_x1_y6_patient607_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3947.9, + "Centroid Y µm": 16278.9, + "Num Detections": 15954, + "Num Negative": 15947, + "Num Positive": 7, + "Positive %": 0.0439, + "Num Positive per mm^2": 3.063 + } +} \ No newline at end of file diff --git a/607/TumorCenter_CD8_block9_x2_y6_patient607_1.json b/607/TumorCenter_CD8_block9_x2_y6_patient607_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a3db125aba0e5c585d475b1fe87a2a38487188f --- /dev/null +++ b/607/TumorCenter_CD8_block9_x2_y6_patient607_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 16116.5, + "Num Detections": 14960, + "Num Negative": 14814, + "Num Positive": 146, + "Positive %": 0.9759, + "Num Positive per mm^2": 69.97 + } +} \ No newline at end of file diff --git a/607/history_text.txt b/607/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9db99c11dcd8ecf53c85feb2cb53ca4f9096c7fd --- /dev/null +++ b/607/history_text.txt @@ -0,0 +1 @@ +The patient has the above-mentioned carcinoma in the sense of a second carcinoma in Z.n. pT1 pN1 tongue edge-tongue base carcinoma, which was treated in 2005 by means of enoral tumor resection, neck dissection on both sides, PEG placement and adjuvant radiochemotherapy up to a maximum of 66.6 Gy. The patient had again had swallowing problems for about six months and an exophytic tumor in the right hypopharyngeal-laryngeal region. Hence the indication for the above procedure. \ No newline at end of file diff --git a/607/icd_codes.txt b/607/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1a0603b1779785fcd6e13a9976159c37231ecdc2 --- /dev/null +++ b/607/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] \ No newline at end of file diff --git a/607/ops_codes.txt b/607/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..362b84c52df26cba01a024bb8874bb38926982cc --- /dev/null +++ b/607/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie: Sonstige[1-631.x ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Permanente Tracheotomie[5-312.0 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] \ No newline at end of file diff --git a/607/patient_clinical_data.json b/607/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4879cbc6e42e81d2bd1bc997ee2282ab5a0293cb --- /dev/null +++ b/607/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 68, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/607/patient_pathological_data.json b/607/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c002d79830c7c98f644ac876776f0f6cf0941d46 --- /dev/null +++ b/607/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "607", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 20.0 +} \ No newline at end of file diff --git a/607/surgery_description.txt b/607/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..99c55d2db3fc03ae617b7b95b83a9cac885684fe --- /dev/null +++ b/607/surgery_description.txt @@ -0,0 +1 @@ +Resection, Laryngectomy, Free flap (Radial), Provox prosthesis diff --git a/607/surgery_report.txt b/607/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0bfd5d0af16c2baefe278b0adeda0dd013e27d84 --- /dev/null +++ b/607/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by anesthesia colleagues. Intubation by the anesthetist. First of all, entry with the small bore tube and inspection of the tumor region. An exophytic tumor is seen, starting in the tonsil loge on the right side, moving caudally, infiltrating the piriform sinus in the entrance area on the hypopharyngeal side wall. The tip of the piriform sinus is free, the tumor extends at the aryepiglottic fold onto the arytenoid cartilage on the right side. The endolarynx itself is free, but postradiogenically altered. Repositioning and placement of a PEG tube using the thread pull-through method. This is successful with good diaphanoscopy. No abnormalities in the esophagus and stomach area. Sterile washing and draping. Creation of an apron flap. However, this is only prepared up to the level of the hyoid bone in order to keep the neck opening as small as possible. Exposure of the cervical vascular sheath. This is very difficult on both sides as the patient has been pre-operated and pre-irradiated. The entire tissue is fibrotically altered and massively scarred. Skeletonization of the larynx with separation of the infrahyal musculature. Exposure of the hyoid bone. Detachment of the thyroid gland on both sides. Release of the piriform sinus on the left side. This cannot be done on the right side due to the tumor. Entering the pharynx on the right side. Disluxation of the epiglottis and inspection of the tumor region. The tumor appears as described above, starting at the tonsil lobe on the right side and extending caudally. First, release the laryngeal region from the pharynx on the right side. Cut around the tumor region with a safety margin of at least 1.5 cm. The tumor extends to the esophageal entrance and can be placed there together with the laryngeal preparation. The specimen is thread-marked and sent for frozen section. The frozen section still shows parts of carcinoma in situ at the entrance to the oesophagus. A large resection specimen is taken here and another marginal specimen is taken for frozen section. Final R0 situation. Lifting the radial artery graft from the left. The radialis graft is 15x9 cm in size, as almost the entire pharynx has to be reconstructed. Only a narrow strip remained. Marking of the graft. Incision around the skin island and extension of the incision on the forearm. Depiction of the brachialis muscle. Exposure of the cephalic vein and other superficial veins. Exposure of the venous star in the crook of the elbow with exploration of the venous confluence between the superficial and deep venous system. Finding the superficial ramus of the radial nerve. This is divided into three branches. All three branches can be dissected and pushed laterally so that they do not have to be integrated into the graft. Locating the radial artery. Ligation and removal of the radial artery. Exposure of the tendons. Lifting the graft from the tendons. It is clear that the radial artery is massively calcified and looks like a rigid calcareous tube in large parts. Despite this, the graft is well perfused throughout the entire preparation time and the hand is also monitored by pulse oximetry and is also completely perfused with over 90% oxygen saturation. The stem is prepared in the usual way. The graft is placed in the crook of the elbow so that two veins are present. One from the superficial system and one from the deep system. The graft is sutured into the pharynx, starting in the tonsil lobe, down to the esophageal entrance. The esophageal entrance is reconstructed using a pointed Z-plasty. This is achieved by advancing the sutures. A Provox prosthesis was previously inserted in the usual way using the pull-through method. The oesophagus is easily passable digitally, so that a myotomy is not necessary. Perform a myotomy in the area of the sternocleidomastoid on both sides. The superior thyroid artery is used for the anastomosis of the radial artery graft for the venous limb. This works without any problems. Use of a coupler for the venous anastomosis, once to the superior thyroid vein and once to a more caudal outlet vessel from the internal jugular vein. Reconstruction of the tracheostoma. Insertion of a flap on the anastomosis side and insertion of a Redon drainage on the opposite side. Two-layer wound closure. Insertion of a tracheostomy tube, suturing of a tracheostomy tube. Completion of the procedure without complications. A nasogastric tube was placed intraoperatively. Please take X-ray and swallow on the 12th postoperative day and, if necessary, build up a diet, antibiotics for 24 hours. \ No newline at end of file diff --git a/608/InvasionFront_CD3_block9_x1_y4_patient608_0.json b/608/InvasionFront_CD3_block9_x1_y4_patient608_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90d78255f225fd0ffb3a4b530bbfea7ffa059034 --- /dev/null +++ b/608/InvasionFront_CD3_block9_x1_y4_patient608_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5722.0, + "Centroid Y µm": 9994.7, + "Num Detections": 17223, + "Num Negative": 16425, + "Num Positive": 798, + "Positive %": 4.633, + "Num Positive per mm^2": 355.43 + } +} \ No newline at end of file diff --git a/608/InvasionFront_CD3_block9_x2_y4_patient608_1.json b/608/InvasionFront_CD3_block9_x2_y4_patient608_1.json new file mode 100644 index 0000000000000000000000000000000000000000..950a42e04dd5d7e956d19bdabef050a4c95eb5ea --- /dev/null +++ b/608/InvasionFront_CD3_block9_x2_y4_patient608_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8395.6, + "Centroid Y µm": 10244.6, + "Num Detections": 18684, + "Num Negative": 18354, + "Num Positive": 330, + "Positive %": 1.766, + "Num Positive per mm^2": 133.75 + } +} \ No newline at end of file diff --git a/608/InvasionFront_CD8_block9_x1_y4_patient608_0.json b/608/InvasionFront_CD8_block9_x1_y4_patient608_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e04f361ee20ef102573f57c8a6936bf94cb2ff92 --- /dev/null +++ b/608/InvasionFront_CD8_block9_x1_y4_patient608_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5522.1, + "Centroid Y µm": 14417.4, + "Num Detections": 18527, + "Num Negative": 17751, + "Num Positive": 776, + "Positive %": 4.188, + "Num Positive per mm^2": 340.05 + } +} \ No newline at end of file diff --git a/608/InvasionFront_CD8_block9_x2_y4_patient608_1.json b/608/InvasionFront_CD8_block9_x2_y4_patient608_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b8386d6ae74bfca1a5c278feb86caf246cc85d86 --- /dev/null +++ b/608/InvasionFront_CD8_block9_x2_y4_patient608_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8145.7, + "Centroid Y µm": 14517.3, + "Num Detections": 18678, + "Num Negative": 18461, + "Num Positive": 217, + "Positive %": 1.162, + "Num Positive per mm^2": 91.25 + } +} \ No newline at end of file diff --git a/608/TumorCenter_CD3_block9_x1_y4_patient608_0.json b/608/TumorCenter_CD3_block9_x1_y4_patient608_0.json new file mode 100644 index 0000000000000000000000000000000000000000..24b636aba409427acef64dcb339190aff8da1082 --- /dev/null +++ b/608/TumorCenter_CD3_block9_x1_y4_patient608_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4322.7, + "Centroid Y µm": 15491.8, + "Num Detections": 16611, + "Num Negative": 16539, + "Num Positive": 72, + "Positive %": 0.4334, + "Num Positive per mm^2": 32.83 + } +} \ No newline at end of file diff --git a/608/TumorCenter_CD3_block9_x2_y4_patient608_1.json b/608/TumorCenter_CD3_block9_x2_y4_patient608_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ee500eea81b1f880b9aa3bbbad3bd50b1856a68 --- /dev/null +++ b/608/TumorCenter_CD3_block9_x2_y4_patient608_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6846.4, + "Centroid Y µm": 15541.8, + "Num Detections": 14005, + "Num Negative": 13612, + "Num Positive": 393, + "Positive %": 2.806, + "Num Positive per mm^2": 175.77 + } +} \ No newline at end of file diff --git a/608/TumorCenter_CD8_block9_x1_y4_patient608_0.json b/608/TumorCenter_CD8_block9_x1_y4_patient608_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f009f962be3c411038fa647d120c232123d4e97 --- /dev/null +++ b/608/TumorCenter_CD8_block9_x1_y4_patient608_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3848.0, + "Centroid Y µm": 11119.1, + "Num Detections": 15295, + "Num Negative": 15235, + "Num Positive": 60, + "Positive %": 0.3923, + "Num Positive per mm^2": 28.59 + } +} \ No newline at end of file diff --git a/608/TumorCenter_CD8_block9_x2_y4_patient608_1.json b/608/TumorCenter_CD8_block9_x2_y4_patient608_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e23a0860513c4642915708066b9e74b8d19ee638 --- /dev/null +++ b/608/TumorCenter_CD8_block9_x2_y4_patient608_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 11144.1, + "Num Detections": 13162, + "Num Negative": 12714, + "Num Positive": 448, + "Positive %": 3.404, + "Num Positive per mm^2": 262.12 + } +} \ No newline at end of file diff --git a/608/history_text.txt b/608/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..28e4cbb8aabf100a140f377bc2687f0787f4ba5d --- /dev/null +++ b/608/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed hypopharyngeal carcinoma on the left. CT shows deep growth in the soft tissues, reaching the level of the hyoid bone and also the lateral left laryngeal skeleton, therefore the above-mentioned operation is indicated. \ No newline at end of file diff --git a/608/icd_codes.txt b/608/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6c803b384690c5bc768ff124953acda1043a466b --- /dev/null +++ b/608/icd_codes.txt @@ -0,0 +1 @@ +Neubildung bösartig Hypopharynx sonstige[C13.8 L] \ No newline at end of file diff --git a/608/ops_codes.txt b/608/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd1d7523a4872385e75a9e55eaa30ded05670b9a --- /dev/null +++ b/608/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.14 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie: Bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] Selektive Neck dissection in 5 Regionen[5-403.04 B] Entnahme freier Radialis-Lappen[5-858.23 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Kleinflächige freie Spalthauttransplantation am Unterarm[5-902.08 L] Sonstige partielle Laryngektomie[5-302.x ] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/608/patient_clinical_data.json b/608/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..855ed33d304942fa09da989ed5fee4a4fb3dfac7 --- /dev/null +++ b/608/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 46, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/608/patient_pathological_data.json b/608/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..081e7cf9d3880f4cccb4ca82ac4e88877fb322c3 --- /dev/null +++ b/608/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "608", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 57, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 22.0 +} \ No newline at end of file diff --git a/608/surgery_description.txt b/608/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/608/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/608/surgery_report.txt b/608/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d5f0941eb91b35447af3cb97eea00307c7ee154 --- /dev/null +++ b/608/surgery_report.txt @@ -0,0 +1 @@ +First of all, pharyngoscopy again after positioning the head: The exophytic tumor can be seen, which is massively located at the described site. Mucosa in the area of the arytenoid fold on the left and postcricoid area edematously thickened. Indication for surgery confirmed. Flap cover with platysmal flap or radial flap probable. Initially in further positioning of the patient. Injection of the corresponding surgical regions and sterile draping after skin disinfection of all regions relevant to the operation. Initially start with an apron flap, which is extended to the left latero-caudally in order to cover the defect with a platysmal flap if necessary. Lift this apron flap subplatysmally in the area of the platysma with underlying fatty tissue on the left side. The external jugular artery is ligated and taken along, paying particular attention to the venous outlets, especially connections to the external jugular vein, anterior jugular vein and facial vein. The apron flap is raised on both sides to the level of the submandibular gland or the level of the hyoid bone. Then neck dissection on the left: Exposure of the sternocleidomastoid muscle anterior border and dissection of the fat lymph node package. Exposure of the internal jugular vein, facial vein. Exposure of the internal carotid artery, externa. Exposure of the vagus nerve border cord, accessorius nerve and hypoglossal nerve. Subsequent evacuation level II to V with visualization of the branches of the cervical plexus which are preserved as far as possible. Subsequent tumor resection via lateral pharyngotomy. Pushing the hypoglossal nerve cranially. Push off the cervical vascular sheath laterally, ligation of the lingual artery. Exposure and preservation of the superior thyroid artery and pushing the thyroid gland in the upper pole latero-caudally. Exposure of the pharyngeal tube. Tumor can be felt massively next to the thyroid cartilage or on the thyroid cartilage. Insertion next to the epiglottis. Expose the tumor successively, cut around the tumor with a safety margin of at least 1.5-2 cm on all sides. The lateral part of the aryepiglottic fold falls caudally to the piriform sinus, medially to the posterior pharyngeal wall and cranially to the beginning of the tonsillar lobe, in each case the entire diameter of the pharyngeal wall. The thyroid cartilage is resected paramedian to the left and just above the beginning of the cricoid cartilage. The specimen is removed and marked with sutures. Carcinoma in situ or small foci, in this case infiltrates, are still recognizable in 2 places in the area of the arytenoid fold and in the area of the base of the tongue to the posterior pharyngeal wall despite the wide resection distance. Therefore, resection of a strip of mucosa at least 1 cm wide from the base of the tongue over the posterior pharyngeal wall to the transition to the piriform sinus. The specimen is marked with sutures away from the tumor. Further resection with removal of the mucosa in the area of the aryepiglottic fold, also a good cm wide up to the entrance to the piriform sinus. Here too, suture markings remote from the tumor. In the frozen section now at most low to moderate grade dysplasia, no carcinoma in situ or invasive carcinoma. Therefore now R0 resection. Neck dissection is now performed on the right side. Here too, removal of levels II to IV as well as parts of 5. Exposure of the structures as on the opposite side. All structures are also preserved as far as possible, especially the vessels. Then tracheostoma creation: The infrahyoid muscles are cut caudally. The thyroid isthmus is then passed underneath, clamped, severed and supplied by means of puncture ligatures. Exposure of the trachea . Wide pedicled modified Björk flap. Epithelialization of this initially caudally. Re-intubation and insertion of an 8 mm Woodbridge tube. The radial flap is removed: After measuring the size of the defect, the flap size is just under 11 x just under 7 cm. Marking on the forearm. Curved skin incision up to the crook of the elbow. First release the flap from the ulnar side while protecting the ulnar artery. Flap elevation subfascially. Subsequent cranial exposure of the superficial vascular system, which remains intact. Subsequent incision of the radialis flap from radial, subfascial. Exposure and preservation of the lateral antebrachial cutaneous nerve. After clamping the radial artery, remove it caudally and ligate. Then lift the flap subfascially with the vascular pedicle. Smaller vessels are bipolarly coagulated or supplied with clips. A variation then becomes apparent in the further course. The radial artery runs under the pronator teres muscle a little further caudally into the brachial artery. The confluence runs under the muscle in the direction of the superficial venous system, which runs above the muscle to the crook of the elbow. Decision to separate the superficial venous system from the deep one after a good confluence could be visualized below the pronator teres muscle. A. radialis is visualized at the entrance to the A. brachialis; the A. interossea, which is first clamped off, is first removed. Saturation at 100 % in each case. Deposition of the interosseous artery. Separation of the brachial artery at the entrance to the brachial artery. Treatment of the site of detachment with 6-0 Vascufil sutures. Subsequent stable saturation in the forearm area. Subsequent removal of the confluence below the pronator teres muscle and removal of the superficial veins with 2 connection options with splitting of the cephalic vein. The veins are ligated cranially. Flap pedicle is flushed with heparin via the superficial deep vein system and via the artery and preserved. Subsequent closure of the forearm defect: A piece of split skin is removed from the thigh area, thickness 07 to 08 mm. The thigh area is treated with a hydrocolloid dressing. Split skin is successively worked into the skin defect. The cranial skin wound is closed in layers. Subsequent octenidine-Mepilex dressing. Loose cloud dressing. Loose absorbent cotton dressing on loosely inserted compresses. Then fit Cramer splint and fix splint with tape bandage. Saturation on the forearm or thumb area always at 100%. Subsequent suturing of the flap into the defect: Radialis flap is inserted into the defect in such a way that the flap stem can be passed through a tunnel underneath the infrahyoid muscles to the opposite side. Successive suturing of the flap into the defect using 3-0 Vicryl single button sutures without tension. Flap is sutured to the remaining thyroid cartilage or laterally to the remains of the previously resected hyoid bone on the left. The epiglottis is not included in the suture so that it remains mobile. Complete tension-free closure. The flap pedicle is then passed underneath the infrahyoid muscles to the opposite side. Conditioning of the superior thyroid artery, which can be anastomosed with 9.0 Ethilon single-button sutures. After opening the clamps, good arterial flow and good venous return. The confluent vein is anastomosed to a facial vein with 2.5 couplers. Here too, after opening the clamps, good venous flow, positive smear phenomenon. Next, anastomosis of an outlet of the cephalic vein with the external jugular vein via 3.5 couplers. Here too, good venous return, positive smear phenomenon. The remaining outlet is treated close to the outlet using clips. Subsequent careful irrigation of all regions in the neck area. Hemostasis. Insertion of a Redon drain on both sides, guided on the right. Successive layer-by-layer skin closure with incision of the apron flap with epithelialization of the tracheostoma. The skin in the area of the pre-platysmal flap was somewhat livid during the operation and was therefore not used to cover the defect, but had recovered by the end of the operation. Overall, radial flap coverage was indicated due to the size of the defect. Finally, insertion of an 8 mm tracheal cannula, which is fixed with sutures. The procedure was completed without complications. Doppler signals and flap perfusion normal. Patient goes to intensive care unit for postoperative monitoring. Please elevate to 30°. Heparin perfusor 500 E/hour which was started intraoperatively please continue postoperatively for 5 days. Regular checks of the flap via transoral inspection or Doppler signals according to the scheme. Antibiotics started intraoperatively should be continued postoperatively with Unacid for approx. 1 week. Overall hypopharyngeal carcinoma with invasion into the lateral laryngeal region. Therefore, in addition to the hyoid bone on the left, thyroid cartilage on the left was also resected. Overall, however, a larynx-preserving procedure was possible and defect coverage using a radial flap was indicated. Postoperative presentation in the interdisciplinary tumor conference according to the histological findings. Nutrition via the inserted PEG tube. On the 10th postoperative day, gruel swallowing and, if necessary, diet build-up. Due to the position of the tube and the resection, protracted dysphagia is to be expected, therefore early initiation of swallowing therapy or swallowing rehabilitation. \ No newline at end of file diff --git a/609/InvasionFront_CD3_block8_x3_y1_patient609_0.json b/609/InvasionFront_CD3_block8_x3_y1_patient609_0.json new file mode 100644 index 0000000000000000000000000000000000000000..78a987d24e56bba0b7534991c4d449f8da5cc38b --- /dev/null +++ b/609/InvasionFront_CD3_block8_x3_y1_patient609_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 12593.3, + "Num Detections": 21421, + "Num Negative": 20757, + "Num Positive": 664, + "Positive %": 3.1, + "Num Positive per mm^2": 274.03 + } +} \ No newline at end of file diff --git a/609/InvasionFront_CD3_block8_x4_y1_patient609_1.json b/609/InvasionFront_CD3_block8_x4_y1_patient609_1.json new file mode 100644 index 0000000000000000000000000000000000000000..08eb1c4d040e89f8c39f39c28eec16d90dd33ae8 --- /dev/null +++ b/609/InvasionFront_CD3_block8_x4_y1_patient609_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 12568.3, + "Num Detections": 12456, + "Num Negative": 12267, + "Num Positive": 189, + "Positive %": 1.517, + "Num Positive per mm^2": 142.55 + } +} \ No newline at end of file diff --git a/609/InvasionFront_CD8_block8_x3_y1_patient609_0.json b/609/InvasionFront_CD8_block8_x3_y1_patient609_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b4f3c79a20b22700ed065720921ece87292acbb7 --- /dev/null +++ b/609/InvasionFront_CD8_block8_x3_y1_patient609_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12593.3, + "Centroid Y µm": 2598.6, + "Num Detections": 22170, + "Num Negative": 20694, + "Num Positive": 1476, + "Positive %": 6.658, + "Num Positive per mm^2": 611.36 + } +} \ No newline at end of file diff --git a/609/InvasionFront_CD8_block8_x4_y1_patient609_1.json b/609/InvasionFront_CD8_block8_x4_y1_patient609_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a4efdc17c0d4803c643b13d724b6944745a5c2d6 --- /dev/null +++ b/609/InvasionFront_CD8_block8_x4_y1_patient609_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15142.0, + "Centroid Y µm": 2798.5, + "Num Detections": 12230, + "Num Negative": 12111, + "Num Positive": 119, + "Positive %": 0.973, + "Num Positive per mm^2": 89.65 + } +} \ No newline at end of file diff --git a/609/TumorCenter_CD3_block8_x3_y1_patient609_0.json b/609/TumorCenter_CD3_block8_x3_y1_patient609_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7d04445f466ece22737131f9b1934a0607cf2c1c --- /dev/null +++ b/609/TumorCenter_CD3_block8_x3_y1_patient609_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10219.6, + "Centroid Y µm": 3523.1, + "Num Detections": 18708, + "Num Negative": 18196, + "Num Positive": 512, + "Positive %": 2.737, + "Num Positive per mm^2": 218.62 + } +} \ No newline at end of file diff --git a/609/TumorCenter_CD3_block8_x4_y1_patient609_1.json b/609/TumorCenter_CD3_block8_x4_y1_patient609_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3eba91324016c624462fb9df556d012b5769c4a2 --- /dev/null +++ b/609/TumorCenter_CD3_block8_x4_y1_patient609_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12643.3, + "Centroid Y µm": 3148.3, + "Num Detections": 19868, + "Num Negative": 19531, + "Num Positive": 337, + "Positive %": 1.696, + "Num Positive per mm^2": 141.09 + } +} \ No newline at end of file diff --git a/609/TumorCenter_CD8_block8_x3_y1_patient609_0.json b/609/TumorCenter_CD8_block8_x3_y1_patient609_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6c6e545e4210a72763ad4ea9dd85e035e0f4593 --- /dev/null +++ b/609/TumorCenter_CD8_block8_x3_y1_patient609_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10594.4, + "Centroid Y µm": 3173.3, + "Num Detections": 18400, + "Num Negative": 18276, + "Num Positive": 124, + "Positive %": 0.6739, + "Num Positive per mm^2": 56.99 + } +} \ No newline at end of file diff --git a/609/TumorCenter_CD8_block8_x4_y1_patient609_1.json b/609/TumorCenter_CD8_block8_x4_y1_patient609_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c6a225980bd9360f2227f6b72bddff0ca77c3e1 --- /dev/null +++ b/609/TumorCenter_CD8_block8_x4_y1_patient609_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 2998.4, + "Num Detections": 13518, + "Num Negative": 13298, + "Num Positive": 220, + "Positive %": 1.627, + "Num Positive per mm^2": 141.41 + } +} \ No newline at end of file diff --git a/609/history_text.txt b/609/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3010aa176c5d05a6c0de68e0c64937df0708da82 --- /dev/null +++ b/609/history_text.txt @@ -0,0 +1 @@ +Tumor in the area of the anterior palatal arch on the right, merging into the glossotonsillar groove. The tumor extends to just before the alveolar ridge. \ No newline at end of file diff --git a/609/icd_codes.txt b/609/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/609/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/609/ops_codes.txt b/609/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..64f645517cb6e4d30044fb8153e6e1a5500f272a --- /dev/null +++ b/609/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie (ohne Adenotomie): Radikal, transoral[5-281.2 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Gaumenbogentumor-Exstirpation[5-272.0 ] Palatektomie Rekonstruktion onA[5-272.2 ] \ No newline at end of file diff --git a/609/patient_clinical_data.json b/609/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ac7014191c61daaac8fa338f04870791ece3ad47 --- /dev/null +++ b/609/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 54, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/609/patient_pathological_data.json b/609/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7646a93463ee26a5dc34b4272a3c77ce4bdac886 --- /dev/null +++ b/609/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "609", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/609/surgery_description.txt b/609/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9528b9e3d17e99779dd7690359e93dfa75eef82e --- /dev/null +++ b/609/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, PEG placement diff --git a/609/surgery_report.txt b/609/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1da53402ff96514e3e8a9c7da104c6f83e9b8011 --- /dev/null +++ b/609/surgery_report.txt @@ -0,0 +1 @@ +Cutting around the tumor with the electric needle far into the healthy tissue and careful dissection of the tumor. Here, the soft palate area is dissected up to the midline. The posterior palatal arch is partially resected. The musculature is exposed. In addition, the resection extends to the base of the tongue. As far as can be assessed intraoperatively, the resection is successful in sano, whereby parts of the posterior palatal arch must be sacrificed. Careful hemostasis. Removal of representative marginal samples which are found to be tumor-free in the frozen section. A histologic R0 resection is therefore also present. Now formation of a caudally pedicled flap in the area of the lateral pharyngeal wall on the right and reconstruction of the posterior palatal arch by subtle suturing with monocryl sutures. Careful hemostasis. The first step is to wait and see whether this reconstruction of the posterior palatal arch is sufficient for the patient's swallowing function. Based on this, only a PEG should be inserted in the usual way. If the patient does not regurgitate, a two-stage neck dissection is recommended in approx. 2-3 weeks. Should regurgitation occur, reconstruction of the soft palate with a radial flap could be performed during the same procedure. As mentioned above, after performing a flexible esophagoscopy and gastroscopy, a PEG is inserted in the usual way. \ No newline at end of file diff --git a/610/InvasionFront_CD3_block2_x1_y8_patient610_0.json b/610/InvasionFront_CD3_block2_x1_y8_patient610_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8decb98c8a2f2ef685360653951384151c5faae1 --- /dev/null +++ b/610/InvasionFront_CD3_block2_x1_y8_patient610_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6246.7, + "Centroid Y µm": 33132.5, + "Num Detections": 15123, + "Num Negative": 14380, + "Num Positive": 743, + "Positive %": 4.913, + "Num Positive per mm^2": 455.12 + } +} \ No newline at end of file diff --git a/610/InvasionFront_CD3_block2_x2_y8_patient610_1.json b/610/InvasionFront_CD3_block2_x2_y8_patient610_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f8077599f27c9b7bde7ddf52a0be7318653c5991 --- /dev/null +++ b/610/InvasionFront_CD3_block2_x2_y8_patient610_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9020.2, + "Centroid Y µm": 33107.5, + "Num Detections": 22198, + "Num Negative": 20956, + "Num Positive": 1242, + "Positive %": 5.595, + "Num Positive per mm^2": 509.36 + } +} \ No newline at end of file diff --git a/610/InvasionFront_CD8_block2_x1_y8_patient610_0.json b/610/InvasionFront_CD8_block2_x1_y8_patient610_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c2f4bd2abc7d8e4932161089d485bc95721b37d3 --- /dev/null +++ b/610/InvasionFront_CD8_block2_x1_y8_patient610_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5147.3, + "Centroid Y µm": 20764.0, + "Num Detections": 15174, + "Num Negative": 14545, + "Num Positive": 629, + "Positive %": 4.145, + "Num Positive per mm^2": 424.11 + } +} \ No newline at end of file diff --git a/610/InvasionFront_CD8_block2_x2_y8_patient610_1.json b/610/InvasionFront_CD8_block2_x2_y8_patient610_1.json new file mode 100644 index 0000000000000000000000000000000000000000..07bd4771528ab73a14c0e655ceb945088a8680cd --- /dev/null +++ b/610/InvasionFront_CD8_block2_x2_y8_patient610_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7870.8, + "Centroid Y µm": 20789.0, + "Num Detections": 23215, + "Num Negative": 22362, + "Num Positive": 853, + "Positive %": 3.674, + "Num Positive per mm^2": 363.08 + } +} \ No newline at end of file diff --git a/610/TumorCenter_CD3_block2_x1_y8_patient610_0.json b/610/TumorCenter_CD3_block2_x1_y8_patient610_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ae74a95a9633cd622f46cfe8f036509172f3d6c --- /dev/null +++ b/610/TumorCenter_CD3_block2_x1_y8_patient610_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 18965.0, + "Num Detections": 17335, + "Num Negative": 16796, + "Num Positive": 539, + "Positive %": 3.109, + "Num Positive per mm^2": 315.65 + } +} \ No newline at end of file diff --git a/610/TumorCenter_CD3_block2_x2_y8_patient610_1.json b/610/TumorCenter_CD3_block2_x2_y8_patient610_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a86225e400957329eec2a3eafd2843c6027b86ab --- /dev/null +++ b/610/TumorCenter_CD3_block2_x2_y8_patient610_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 19314.8, + "Num Detections": 22808, + "Num Negative": 20490, + "Num Positive": 2318, + "Positive %": 10.16, + "Num Positive per mm^2": 952.17 + } +} \ No newline at end of file diff --git a/610/TumorCenter_CD8_block2_x1_y8_patient610_0.json b/610/TumorCenter_CD8_block2_x1_y8_patient610_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0e70855a957e65dcd4f90b76eee3432622bf2e6 --- /dev/null +++ b/610/TumorCenter_CD8_block2_x1_y8_patient610_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 19564.6, + "Num Detections": 17045, + "Num Negative": 16649, + "Num Positive": 396, + "Positive %": 2.323, + "Num Positive per mm^2": 229.23 + } +} \ No newline at end of file diff --git a/610/TumorCenter_CD8_block2_x2_y8_patient610_1.json b/610/TumorCenter_CD8_block2_x2_y8_patient610_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb5b5e33acc0ec6ea12e18aba26011872b8f7f60 --- /dev/null +++ b/610/TumorCenter_CD8_block2_x2_y8_patient610_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8470.5, + "Centroid Y µm": 19689.6, + "Num Detections": 22758, + "Num Negative": 21907, + "Num Positive": 851, + "Positive %": 3.739, + "Num Positive per mm^2": 364.2 + } +} \ No newline at end of file diff --git a/610/history_text.txt b/610/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/610/icd_codes.txt b/610/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/610/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/610/ops_codes.txt b/610/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..08e83c9c19fa16e45e76baf8939bedb676b92de5 --- /dev/null +++ b/610/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Weichgaumenteilresektion[5-272.1 ] \ No newline at end of file diff --git a/610/patient_clinical_data.json b/610/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9de7357df4ba0b01f30fbca57e3c4ea85c16b8bc --- /dev/null +++ b/610/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 70, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/610/patient_pathological_data.json b/610/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a23c2428aa017f44dd8449d87186e4c95e4cb5ba --- /dev/null +++ b/610/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "610", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/610/surgery_description.txt b/610/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..59fa39428e621c23768d05d4fce624747c395cdb --- /dev/null +++ b/610/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection diff --git a/610/surgery_report.txt b/610/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd502e2b6ec2e0badee9364170d33df928fb876e --- /dev/null +++ b/610/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then insertion of the tonsil plug and inspection of the tumor. The tumor is approx. 3-4 cm in size and located on the lateral pharyngeal wall and soft palate. The tonsil lobe is not affected, nor is the base of the tongue. Cutting around the tumor with the monopolar needle, then further dissection with scissors and bipolar forceps. Removal of the entire tumor preparation. This is thread-marked for final histology. Then removal of marginal samples. Intraoperative demonstration to . The surgeon initially decides to wait and see whether the patient needs defect coverage at all. The uvula is still intact. A small part of the soft palate on the left side is also preserved. The tonsil is preserved, the posterior palatal arch is partially resected. Hemostasis using bipolar coagulation and completion of the procedure without complications. \ No newline at end of file diff --git a/611/InvasionFront_CD3_block9_x5_y3_patient611_0.json b/611/InvasionFront_CD3_block9_x5_y3_patient611_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e920747fa3632f654f968f16c34ae1b284aff9b --- /dev/null +++ b/611/InvasionFront_CD3_block9_x5_y3_patient611_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 8420.5, + "Num Detections": 26018, + "Num Negative": 20331, + "Num Positive": 5687, + "Positive %": 21.86, + "Num Positive per mm^2": 2166.1 + } +} \ No newline at end of file diff --git a/611/InvasionFront_CD3_block9_x6_y3_patient611_1.json b/611/InvasionFront_CD3_block9_x6_y3_patient611_1.json new file mode 100644 index 0000000000000000000000000000000000000000..39a4b6a9943119cc06be5748b90e8d97763f2c83 --- /dev/null +++ b/611/InvasionFront_CD3_block9_x6_y3_patient611_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21363.7, + "Centroid Y µm": 8570.5, + "Num Detections": 22778, + "Num Negative": 18605, + "Num Positive": 4173, + "Positive %": 18.32, + "Num Positive per mm^2": 1784.0 + } +} \ No newline at end of file diff --git a/611/InvasionFront_CD8_block9_x5_y3_patient611_0.json b/611/InvasionFront_CD8_block9_x5_y3_patient611_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e2a771b720d0431f699e1876871b593f2067cec5 --- /dev/null +++ b/611/InvasionFront_CD8_block9_x5_y3_patient611_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 12243.5, + "Num Detections": 27413, + "Num Negative": 24054, + "Num Positive": 3359, + "Positive %": 12.25, + "Num Positive per mm^2": 1297.1 + } +} \ No newline at end of file diff --git a/611/InvasionFront_CD8_block9_x6_y3_patient611_1.json b/611/InvasionFront_CD8_block9_x6_y3_patient611_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67c4a8fc412e35e29f574eda21083a4c55ec75c7 --- /dev/null +++ b/611/InvasionFront_CD8_block9_x6_y3_patient611_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20814.0, + "Centroid Y µm": 12268.5, + "Num Detections": 24325, + "Num Negative": 21921, + "Num Positive": 2404, + "Positive %": 9.883, + "Num Positive per mm^2": 1040.2 + } +} \ No newline at end of file diff --git a/611/TumorCenter_CD3_block9_x5_y3_patient611_0.json b/611/TumorCenter_CD3_block9_x5_y3_patient611_0.json new file mode 100644 index 0000000000000000000000000000000000000000..820d46d6ddc90cde99620d107b82081295dda12b --- /dev/null +++ b/611/TumorCenter_CD3_block9_x5_y3_patient611_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16841.1, + "Centroid Y µm": 13367.9, + "Num Detections": 25076, + "Num Negative": 17756, + "Num Positive": 7320, + "Positive %": 29.19, + "Num Positive per mm^2": 2745.2 + } +} \ No newline at end of file diff --git a/611/TumorCenter_CD3_block9_x6_y3_patient611_1.json b/611/TumorCenter_CD3_block9_x6_y3_patient611_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f38bb20c77da4feb0ccb01f645276d92cc8696c2 --- /dev/null +++ b/611/TumorCenter_CD3_block9_x6_y3_patient611_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 13517.8, + "Num Detections": 27490, + "Num Negative": 18332, + "Num Positive": 9158, + "Positive %": 33.31, + "Num Positive per mm^2": 3332.2 + } +} \ No newline at end of file diff --git a/611/TumorCenter_CD8_block9_x5_y3_patient611_0.json b/611/TumorCenter_CD8_block9_x5_y3_patient611_0.json new file mode 100644 index 0000000000000000000000000000000000000000..098cd4452ef5975069129e9cc77a79611accde86 --- /dev/null +++ b/611/TumorCenter_CD8_block9_x5_y3_patient611_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 8020.8, + "Num Detections": 29370, + "Num Negative": 25820, + "Num Positive": 3550, + "Positive %": 12.09, + "Num Positive per mm^2": 1327.8 + } +} \ No newline at end of file diff --git a/611/TumorCenter_CD8_block9_x6_y3_patient611_1.json b/611/TumorCenter_CD8_block9_x6_y3_patient611_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6683650bd845381f7f5d9808f00a83a75bebf104 --- /dev/null +++ b/611/TumorCenter_CD8_block9_x6_y3_patient611_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 7920.8, + "Num Detections": 30382, + "Num Negative": 24777, + "Num Positive": 5605, + "Positive %": 18.45, + "Num Positive per mm^2": 2043.1 + } +} \ No newline at end of file diff --git a/611/history_text.txt b/611/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/611/icd_codes.txt b/611/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..964ea565a3543cfb06f9934046a80ba87cbe9a54 --- /dev/null +++ b/611/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 B] \ No newline at end of file diff --git a/611/ops_codes.txt b/611/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9a544b4b724a93468376b405f5ff376f5ced0001 --- /dev/null +++ b/611/ops_codes.txt @@ -0,0 +1 @@ +Laterale Pharyngotomie[5-290.3 ] Weichgaumenteilresektion[5-272.1 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Permanente Tracheotomie[5-312.0 ] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/611/patient_clinical_data.json b/611/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4113d554f14ae271141195725aff0411726ab87a --- /dev/null +++ b/611/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 44, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/611/patient_pathological_data.json b/611/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4cd2c5f5b4cd4a283d53e23dddb46b1ec233d3e1 --- /dev/null +++ b/611/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "611", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/611/surgery_description.txt b/611/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d5b66f48fd0d95ecef7fda073a132cfe30131460 --- /dev/null +++ b/611/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Modified radical neck dissection bilateral, Defect coverage (Radial), Tracheotomy diff --git a/611/surgery_report.txt b/611/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2135bcab509c026993bb737a0ea7ac455becfbfc --- /dev/null +++ b/611/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then insertion of a tonsillectomy tube and inspection of the tumor region. A large, exophytic tumor mass was found, starting from the tonsil on the right side, passing over to the soft palate up to the uvula and the base of the tongue. Start with transoral tumor resection in the area of the soft palate with a safety margin of more than 1 cm. Then successive tumor resection including the entire anterior palatal arch and the largest part of the posterior palatal arch and a small part of the base of the tongue on the right side. The tumor must be resected far to the side so that fatty tissue from the neck is already visible in the lateral oropharyngeal side wall. However, there is still no fistula, but the border to the soft tissue of the neck can no longer be guaranteed. Due to the large extent of the tumor resection, the lack of a soft palate and the expected fistula laterally into the soft tissues of the neck, the decision was made to cover the defect with a radialis graft. Initially, the neck dissection was performed on the left side, as it was not possible to assess whether the internal jugular vein could really remain intact on the right side. For this purpose, the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle and the submandibular gland were exposed. Then exposure of the cervical vascular sheath, dissection of the internal jugular vein, which can be completely preserved. Then expose the facial nerve and the lingual nerve of the superior thyroid artery and release the neck preparation IIa to Va while sparing the plexus branches. Neck dissection on the right side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle and the internal jugular and facial veins. Exposure of the submandibular gland, removal of the submandibular gland. Dissection of the digastric muscle. Release of the neck preparation IIa to Va while sparing the plexus branches. There is also a very large lymph node conglomerate on this side, which extends from level II to level IV; this could be integrated into the neck preparation and removed without destroying the vessels and nerves. Parallel to the neck dissection on the left side, the radialis graft is lifted, here for marking the graft on the forearm, cutting around the graft and extending the skin incision into the elbow. Exposure of the venous star in the elbow, showing the superficial and deep venous system with dissection of the confluence. Exposure of the brachioradialis muscle. Exposure of the superficial ramus of the radial nerve. Exposure of the radial artery, clamping and cutting of the radial artery under pulsoxymetric control. Here 100% saturation in the left hand. Lift the graft from the veins in the usual manner, then dissect the stem up to the elbow and place the graft, taking one superficial and one deep vein with it. The transoral suturing of the transplant in the oropharynx is then very difficult, as the tongue, the uvula and the entire mucous membrane in the pharynx are already very swollen. In some cases, the graft has to be sutured into the lower area via the oropharyngotomy performed during the neck dissection. Finally, it is possible to fit the graft without tension, so that it does not tear out in the soft palate area, then repositioning to perform the anastomosis. First preparation and preparation of the superior thyroid artery. However, it turns out that there is hardly sufficient flow in the superior thyroid artery and the entire vessel is far too small to anastomose. Then turn to the lingual artery. Same problem here. Then search for the laryngeal artery, which is surprisingly relatively large and also has sufficient blood flow. Therefore, use the laryngeal artery to perform the anastomosis in the arterial area and then perform the venous anastomosis with an accompanying vein of the facial vein and the facial vein itself. The blood supply to the graft is good. Then insertion of a flap on the right side and insertion of a Redon drainage on the left side and two-layer wound closure. A tracheotomy was performed beforehand in the usual manner. This involved cutting the thyroid isthmus and performing a visor tracheotomy without a Björk flap between the 2nd and 3rd tracheal cartilage, creating a mucocutaneous anastomosis and reintubation with a tracheostomy tube. Continue antibiotics for 24 hours. The patient goes to the intensive care unit overnight and is allowed to wake up the next morning. Then nutrition via the existing PEG tube for 10 days, followed by an x-ray and food preparation. \ No newline at end of file diff --git a/612/InvasionFront_CD3_block9_x3_y3_patient612_0.json b/612/InvasionFront_CD3_block9_x3_y3_patient612_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b2a9b49aec81cfd7d4df22bb993f15bde9f9e1b --- /dev/null +++ b/612/InvasionFront_CD3_block9_x3_y3_patient612_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 8195.7, + "Num Detections": 28967, + "Num Negative": 26337, + "Num Positive": 2630, + "Positive %": 9.079, + "Num Positive per mm^2": 921.63 + } +} \ No newline at end of file diff --git a/612/InvasionFront_CD3_block9_x4_y3_patient612_1.json b/612/InvasionFront_CD3_block9_x4_y3_patient612_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7d87c6ac9e357698addcf4a310397d5d5024f2fd --- /dev/null +++ b/612/InvasionFront_CD3_block9_x4_y3_patient612_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 8270.6, + "Num Detections": 24010, + "Num Negative": 22035, + "Num Positive": 1975, + "Positive %": 8.226, + "Num Positive per mm^2": 765.7 + } +} \ No newline at end of file diff --git a/612/InvasionFront_CD8_block9_x3_y3_patient612_0.json b/612/InvasionFront_CD8_block9_x3_y3_patient612_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eb68c1754faee791f579975c4d534d482856c632 --- /dev/null +++ b/612/InvasionFront_CD8_block9_x3_y3_patient612_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12918.2, + "Centroid Y µm": 12318.5, + "Num Detections": 26908, + "Num Negative": 13011, + "Num Positive": 13897, + "Positive %": 51.65, + "Num Positive per mm^2": 4913.1 + } +} \ No newline at end of file diff --git a/612/InvasionFront_CD8_block9_x4_y3_patient612_1.json b/612/InvasionFront_CD8_block9_x4_y3_patient612_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ca19247818f36c192e2e10b7a6be8467077c3ee9 --- /dev/null +++ b/612/InvasionFront_CD8_block9_x4_y3_patient612_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15616.7, + "Centroid Y µm": 12293.5, + "Num Detections": 22943, + "Num Negative": 13511, + "Num Positive": 9432, + "Positive %": 41.11, + "Num Positive per mm^2": 3706.0 + } +} \ No newline at end of file diff --git a/612/TumorCenter_CD3_block9_x3_y3_patient612_0.json b/612/TumorCenter_CD3_block9_x3_y3_patient612_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f785473c8eac1a6c65f3593e9365a5e6098805a --- /dev/null +++ b/612/TumorCenter_CD3_block9_x3_y3_patient612_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11643.8, + "Centroid Y µm": 13193.0, + "Num Detections": 28257, + "Num Negative": 26106, + "Num Positive": 2151, + "Positive %": 7.612, + "Num Positive per mm^2": 800.03 + } +} \ No newline at end of file diff --git a/612/TumorCenter_CD3_block9_x4_y3_patient612_1.json b/612/TumorCenter_CD3_block9_x4_y3_patient612_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8ba6d7603fcf6fb3c15cd6a69467fc6dc4f93309 --- /dev/null +++ b/612/TumorCenter_CD3_block9_x4_y3_patient612_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14242.5, + "Centroid Y µm": 13268.0, + "Num Detections": 23545, + "Num Negative": 17064, + "Num Positive": 6481, + "Positive %": 27.53, + "Num Positive per mm^2": 2384.1 + } +} \ No newline at end of file diff --git a/612/TumorCenter_CD8_block9_x3_y3_patient612_0.json b/612/TumorCenter_CD8_block9_x3_y3_patient612_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ea8390ba2f3d1565c1438bb3938f9086de944a3a --- /dev/null +++ b/612/TumorCenter_CD8_block9_x3_y3_patient612_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 8295.6, + "Num Detections": 28396, + "Num Negative": 26221, + "Num Positive": 2175, + "Positive %": 7.66, + "Num Positive per mm^2": 805.78 + } +} \ No newline at end of file diff --git a/612/TumorCenter_CD8_block9_x4_y3_patient612_1.json b/612/TumorCenter_CD8_block9_x4_y3_patient612_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c902fca72bed2c14802098b442e77e1c39d7aa2 --- /dev/null +++ b/612/TumorCenter_CD8_block9_x4_y3_patient612_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 8220.6, + "Num Detections": 22902, + "Num Negative": 14304, + "Num Positive": 8598, + "Positive %": 37.54, + "Num Positive per mm^2": 3162.0 + } +} \ No newline at end of file diff --git a/612/history_text.txt b/612/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/612/icd_codes.txt b/612/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aad5aa59aa5f79ebf0ec3cacf0eec134f08b928d --- /dev/null +++ b/612/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren Verhaltens Lippe Mundhöhle und Pharynx[D37.0 L] \ No newline at end of file diff --git a/612/ops_codes.txt b/612/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..927a53aec6c1aa213cdf4bb615debc1359a3f03e --- /dev/null +++ b/612/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/612/patient_clinical_data.json b/612/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..16a5a25339e2c0cf55ca6787f92fb3befd60cc0e --- /dev/null +++ b/612/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/612/patient_pathological_data.json b/612/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2eadf58b199516a1898052899acbf00524779f86 --- /dev/null +++ b/612/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "612", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/612/surgery_description.txt b/612/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d04767710453c5157516a5ac6cd28d3bbe29a18b --- /dev/null +++ b/612/surgery_description.txt @@ -0,0 +1 @@ +Tumor-tonsillectomy, Panendoscopy diff --git a/612/surgery_report.txt b/612/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..938ff4a8e71105a9409c0d6963a4edfc9b174fb4 --- /dev/null +++ b/612/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. Laryngoscopic adjustment of the glottic plane. The 0° view reveals a normal glottis with an inconspicuous subglottis and trachea up to the main bronchi. The patient is then intubated by the surgeon without any problems. Repositioning of the patient for flexible esophagogastroscopy: Here, the flexible instrument is inserted into the esophagus without any problems. Mirroring under visualization into the stomach, where a regular fold relief is visible. After aspiration of the insufflated air, the patient is reflected back and the esophageal mucosa is inspected, which is also inconspicuous throughout the procedure. Repositioning of the patient for inspection of the oral cavity: regular inconspicuous conditions here. Insertion of the size C small bore tube and inspection of the oropharynx, hypopharynx and larynx: An exophytic mass is seen in the area of the left tonsil, which is significantly larger than the right one. The tonsil itself is mobile and can be easily moved over the base. The other areas of the hypopharynx and larynx are non-irritant and unremarkable. Insertion of the mouth retractor and re-inspection of the left tonsil. This shows central exophytic changes. Then mucosal incision close to the uvula and sharp dissection of the anterior and posterior palatal arch. Exposure of the upper pole vessels. The capsule appears to respect the upper tonsil pole. No evidence of tumor infiltration. Therefore, coagulation and transection of the upper pole vessels and release of the tonsil from the upper pole caudally. Here, too, there is no evidence of capsular overgrowth. The tonsil is detached from the pharyngeal wall in the sense of a dissection technique. In the caudal region, the capsule appears to be penetrated by the tumor and to grow infiltrating into the pharyngeal wall. Therefore, dissection in the depth of the pharyngeal wall down to the musculature. Dissection is performed up to the caudal pole, where the tonsil is deposited after coagulation of the lower pole vessels with a portion of the tongue base tonsil. In the area of the caudal end of the tonsil, where the capsule appeared to have been exceeded by the tumor, the pharyngeal muscles are resected and a marginal sample is taken. The marginal sample is sent separately for histopathological examination. A mucosoplasty is performed. Intensive bleeding control. Completion of the procedure if the wound is dry. Final consultation with the anesthetist. Further procedure depending on the histopathological result. \ No newline at end of file diff --git a/613/InvasionFront_CD3_block15_x1_y2_patient613_0.json b/613/InvasionFront_CD3_block15_x1_y2_patient613_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02a95227ae7a42b425f66200cf50da3721e05321 --- /dev/null +++ b/613/InvasionFront_CD3_block15_x1_y2_patient613_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5347.2, + "Centroid Y µm": 15766.7, + "Num Detections": 20637, + "Num Negative": 20090, + "Num Positive": 547, + "Positive %": 2.651, + "Num Positive per mm^2": 231.39 + } +} \ No newline at end of file diff --git a/613/InvasionFront_CD3_block15_x2_y2_patient613_1.json b/613/InvasionFront_CD3_block15_x2_y2_patient613_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6fad0c53018ad83692cbacbb12041cdf8a2310fc --- /dev/null +++ b/613/InvasionFront_CD3_block15_x2_y2_patient613_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7945.8, + "Centroid Y µm": 15541.8, + "Num Detections": 17709, + "Num Negative": 16384, + "Num Positive": 1325, + "Positive %": 7.482, + "Num Positive per mm^2": 625.56 + } +} \ No newline at end of file diff --git a/613/InvasionFront_CD8_block15_x1_y2_patient613_0.json b/613/InvasionFront_CD8_block15_x1_y2_patient613_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2866f41d2449741d9e15d30d13f7e7066a6da804 --- /dev/null +++ b/613/InvasionFront_CD8_block15_x1_y2_patient613_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.6, + "Centroid Y µm": 5125.1, + "Num Detections": 18596, + "Num Negative": 17931, + "Num Positive": 665, + "Positive %": 3.576, + "Num Positive per mm^2": 298.66 + } +} \ No newline at end of file diff --git a/613/InvasionFront_CD8_block15_x2_y2_patient613_1.json b/613/InvasionFront_CD8_block15_x2_y2_patient613_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d33f52b8cf86a830eee040df22c6e0e5b159bd3e --- /dev/null +++ b/613/InvasionFront_CD8_block15_x2_y2_patient613_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6414.4, + "Centroid Y µm": 5016.3, + "Num Detections": 15141, + "Num Negative": 12710, + "Num Positive": 2431, + "Positive %": 16.06, + "Num Positive per mm^2": 1295.6 + } +} \ No newline at end of file diff --git a/613/TumorCenter_CD3_block15_x1_y2_patient613_0.json b/613/TumorCenter_CD3_block15_x1_y2_patient613_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b10abda8d6b7612a7326f1881e73bafbe37a26c --- /dev/null +++ b/613/TumorCenter_CD3_block15_x1_y2_patient613_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 8545.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/613/TumorCenter_CD3_block15_x2_y2_patient613_1.json b/613/TumorCenter_CD3_block15_x2_y2_patient613_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d5e11f36b49719e83a00d3319a5e8933236ee3f --- /dev/null +++ b/613/TumorCenter_CD3_block15_x2_y2_patient613_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 8470.5, + "Num Detections": 19007, + "Num Negative": 18746, + "Num Positive": 261, + "Positive %": 1.373, + "Num Positive per mm^2": 121.34 + } +} \ No newline at end of file diff --git a/613/TumorCenter_CD8_block15_x1_y2_patient613_0.json b/613/TumorCenter_CD8_block15_x1_y2_patient613_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee1285372e4caad74a50a2f095952684ef2e4998 --- /dev/null +++ b/613/TumorCenter_CD8_block15_x1_y2_patient613_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 5372.2, + "Num Detections": 21758, + "Num Negative": 21141, + "Num Positive": 617, + "Positive %": 2.836, + "Num Positive per mm^2": 272.39 + } +} \ No newline at end of file diff --git a/613/TumorCenter_CD8_block15_x2_y2_patient613_1.json b/613/TumorCenter_CD8_block15_x2_y2_patient613_1.json new file mode 100644 index 0000000000000000000000000000000000000000..15d04bc4b9f730fce62c261cd4fd1060cf00d38b --- /dev/null +++ b/613/TumorCenter_CD8_block15_x2_y2_patient613_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8945.3, + "Centroid Y µm": 5147.3, + "Num Detections": 21558, + "Num Negative": 20717, + "Num Positive": 841, + "Positive %": 3.901, + "Num Positive per mm^2": 363.09 + } +} \ No newline at end of file diff --git a/613/history_text.txt b/613/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..36e3d64c8d288d14cb15b94932e6f8490a099c3c --- /dev/null +++ b/613/history_text.txt @@ -0,0 +1 @@ +The patient had a histologically confirmed cT3a cN2b oral cavity carcinoma on the right side in combination with panendoscopy, CT and ultrasound diagnostics. In our interdisciplinary tumor conference, the primary surgical procedure was recommended. \ No newline at end of file diff --git a/613/icd_codes.txt b/613/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b726963807f048843213f2656edbce103649d7e --- /dev/null +++ b/613/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, nicht näher bezeichnet[C02.9 ] \ No newline at end of file diff --git a/613/ops_codes.txt b/613/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..954905b697257bc51c305062f01b08817f500ee5 --- /dev/null +++ b/613/ops_codes.txt @@ -0,0 +1 @@ +Hemiglossektomie durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 R] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] \ No newline at end of file diff --git a/613/patient_clinical_data.json b/613/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..572f4c2c821a06b0210e784e060a4854846aaf0d --- /dev/null +++ b/613/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/613/patient_pathological_data.json b/613/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d638966ead992ba9eaa076e77c5cc0210791e15e --- /dev/null +++ b/613/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "613", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/613/surgery_description.txt b/613/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..25c58005c68d049d6c1545dfb4b8923cad754f00 --- /dev/null +++ b/613/surgery_description.txt @@ -0,0 +1 @@ +Transoral and trans-cervical resection (Hemiglossectomy), Reconstruction with microvascular ALT transplant, Bilateral neck dissection, Tracheotomy, PEG diff --git a/613/surgery_report.txt b/613/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..56a6224b7bab5feb2e56d76bca42302e9b627458 --- /dev/null +++ b/613/surgery_report.txt @@ -0,0 +1 @@ +First, inspection of the primary tumor region. As described above, this revealed an ulcerative lesion of the posterior floor of the mouth with infiltration of the posterior border of the tongue and superficial growth over the lateral border of the tongue to the lower surface of the tongue as well as extensive submucosal tumor extension dorsally to the base of the tongue, occupying a good 1/3 of the base of the tongue. CT diagnostics also show growth in a cervical direction with infiltration of the muscles of the floor of the mouth. The first step is to insert a PEG. This is done with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach, excellent diaphanoscopy, problem-free puncture of the stomach and subsequent placement of the PEG tube using the usual thread pull-through method and careful placement of the PEG plate in clearly cachectic patients. The patient is then repositioned and prepared for the transoral procedure. This is done with the open mouth retractor. Resection of the process with superficial growth in the area of the tongue edge and the underside of the tongue with a safety margin in the mucosa and at the basal level of a good 1 cm. Inclusion of the entire lateral floor of the mouth and resection in the area of the tongue going dorsally to the midline and here initially extending to the linea terminalis. The entire area of the lateral floor of the mouth, glossotonsillar groove, underside of the tongue, floor of the mouth and free edge of the tongue is now covered with marginal samples, all of which are diagnosed as tumor-free and dysplasia-free. The patient is now repositioned for the transcervical, submandibular incision procedure. Cut through skin and subcutaneous tissue. Dissection of the cranial and caudal platysma. First perform the neck dissection. To do this, expose and protect the sternocleidomastoid muscle, external jugular vein and auricularis magnus nerve. Exposure of the omohyoid muscle, release of the submandibular gland and exposure of the digastric muscle. Removal of the anterior neck preparation with careful protection of the facial vein, superior thyroid artery, hypoglossal nerve, cervical artery and with removal of some macroscopically suspicious ones in the jugulofacial angle, but without signs of environmental infiltration. Free dissection of the internal jugular vein with exposure and protection of the common carotid artery and vagus nerve. Exposure of the accessory nerve, clearing of the accessory triangle and careful completion caudally to level V with careful protection and exposure of the cervical plexus branches. Finally, if the wound is dry, extirpation of the submandibular gland and resection of the digastric muscle, both of which are not infiltrated. After gland removal, entry into the posterior floor of the mouth and achievement of enoral resection status. Now widen cranially. Displacement of the facial vein and artery. Exposure and later transection of the lingual artery, the hypoglossal nerve is initially preserved and exposed. It can now be seen that the nerve is directly infiltrated anteriorly by the tumor. There is also clear infiltration of the tumor into the muscles of the floor of the mouth. Extensive resection of the muscles of the floor of the mouth. Now by pulse.................................. of the tongue, a good overview is also obtained towards the base of the tongue and resection of the tumor with sufficient safety distance, especially in the area of the base of the tongue. En bloc and macroscopically in toto on the specimen. The remaining parts in the mucosal area are now also covered with margin samples. In the area of the dorsal base of the tongue, CIS is suspected in the frozen section diagnosis despite the macroscopically large safety margin. Therefore, a covering resection is performed here. Otherwise, in sano resection on all sides for the carcinoma. This results in a partial pharyngectomy and a hemiglossectomy on the right side with a total defect measuring 15 x 7 cm and a need for reconstruction. Neck dissection of the left side and tracheotomy are performed first. Neck dissection: cutting through skin and subcutaneous tissue. Corresponding to the opposite side. Separation and dissection of the platysma. Exposure of the sternocleidomastoid muscle, external jugular vein and auricular nerve. Exposure of the omohyoid muscle, release of the submandibular gland and removal of the capsule. Exposure of the digastric muscle. Removal of an anterior neck preparation with careful protection of the facial vein, the superior thyroid artery, the hypoglossal nerve and the cervical artery. Free preparation of the cervical vascular sheath with exposure of the common carotid artery and the vagus nerve. Exposure and preservation of the accessorius nerve, completion in the direction of level Va with careful protection of the cervical plexus branches. In conclusion, no suspicious conditions here. Careful irrigation of the wound. Insertion of a 10-gauge Redon drain and careful two-layer wound closure. Then perform the tracheotomy. To do this, make a horizontal incision approx. 1 cm below the cricoid cartilage with the larynx relatively high. Cut through the skin and subcutaneous tissue. Expose the infrahyoid musculature. Entering the infrahyoid musculature. Exposure of the anterior surface of the trachea. Exposure of the slender thyroid isthmus and transection. Insertion between the 2nd and 3rd tracheal ring. Creation of a wide tracheotomy. Successive suturing while performing the mucocutaneous anastomosis and finally problem-free reintubation to a size 9 low cuff cannula, which is suture-fixed. An antero-lateral transfemoral graft is then lifted from the right. After doppler sonographic identification of the main perforator and a secondary perforator, a medial incision is made after marking a graft measuring 15 x 8 cm in total. Medial transection of skin and subcutaneous tissue. Separation of the fascia lata. Exposure and securing of the rectus femoris muscle, widening of the incision, strictly subfascial release of the rectus femoris muscle and exposure of the pedicle vessel. Further incision of the graft, exposure of the main perforator, which has a small musculocutaneous course. Free preparation and exposure of the strong perforator from which both doppler sonographically marked vessels originate. Complete cutting of the graft, including the fascia lata. Isolation on the perforator and vascular pedicle. Removal of a muscle margin around the main perforator and removal of the vital graft and treatment of the feeding and draining vessels. Finally, careful wound inspection. Insertion of a 10-gauge Redon drain and strong multi-layer wound closure. This is followed by combined transcervical and transoral incorporation of the graft. Due to the extent of the graft, the conditions were somewhat more difficult, but in the end the conditions were intact on all sides and the reconstruction of half of the tongue was good, with the remaining tongue retaining its mobility. Conditioning of the vasa facialia. First, perform the arterial anastomosis with 8.0 Ethilon. This is successful and sufficient. Immediate regular and strong venous return flow via both draining veins. The facial vein is now anastomosed with the coupler system, once size 3.0, once 2.0. Finally, regular pedicle pulsation, positive spreading phenomenon and good graft perfusion so that a rubber flap is inserted and the procedure is carefully closed in two layers and completed. Conclusion: Intraoperative R0 resected cT4a cN2b oral cavity carcinoma, mainly in the right-sided tongue area. If the graft heals properly, the first attempts at swallowing and, if necessary, swallowing training can be started from the 8th to 10th postoperative day. Presentation in our interdisciplinary tumor conference for adjuvant therapy that is certainly indicated. \ No newline at end of file diff --git a/614/InvasionFront_CD3_block10_x3_y9_patient614_0.json b/614/InvasionFront_CD3_block10_x3_y9_patient614_0.json new file mode 100644 index 0000000000000000000000000000000000000000..694fa760c730485daf1fa26d416480e2399029b1 --- /dev/null +++ b/614/InvasionFront_CD3_block10_x3_y9_patient614_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12143.6, + "Centroid Y µm": 28509.9, + "Num Detections": 20249, + "Num Negative": 19706, + "Num Positive": 543, + "Positive %": 2.682, + "Num Positive per mm^2": 226.35 + } +} \ No newline at end of file diff --git a/614/InvasionFront_CD3_block10_x4_y9_patient614_1.json b/614/InvasionFront_CD3_block10_x4_y9_patient614_1.json new file mode 100644 index 0000000000000000000000000000000000000000..664f94fd248ee47e2e274caf8defdc129c1101fd --- /dev/null +++ b/614/InvasionFront_CD3_block10_x4_y9_patient614_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 28859.7, + "Num Detections": 20340, + "Num Negative": 19420, + "Num Positive": 920, + "Positive %": 4.523, + "Num Positive per mm^2": 394.7 + } +} \ No newline at end of file diff --git a/614/InvasionFront_CD8_block10_x3_y9_patient614_0.json b/614/InvasionFront_CD8_block10_x3_y9_patient614_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c302070effa9b67049a06b72e487b8e8a856ba3e --- /dev/null +++ b/614/InvasionFront_CD8_block10_x3_y9_patient614_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12368.5, + "Centroid Y µm": 29159.6, + "Num Detections": 21239, + "Num Negative": 20944, + "Num Positive": 295, + "Positive %": 1.389, + "Num Positive per mm^2": 123.16 + } +} \ No newline at end of file diff --git a/614/InvasionFront_CD8_block10_x4_y9_patient614_1.json b/614/InvasionFront_CD8_block10_x4_y9_patient614_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ab359d28d2c863edeaee5a5fdd613e34ce269eef --- /dev/null +++ b/614/InvasionFront_CD8_block10_x4_y9_patient614_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15092.0, + "Centroid Y µm": 29209.5, + "Num Detections": 18672, + "Num Negative": 18108, + "Num Positive": 564, + "Positive %": 3.021, + "Num Positive per mm^2": 239.77 + } +} \ No newline at end of file diff --git a/614/TumorCenter_CD3_block10_x3_y9_patient614_0.json b/614/TumorCenter_CD3_block10_x3_y9_patient614_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8930a44738b17587a615ecf617bb33ab4103fc1b --- /dev/null +++ b/614/TumorCenter_CD3_block10_x3_y9_patient614_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 22288.2, + "Num Detections": 18782, + "Num Negative": 18229, + "Num Positive": 553, + "Positive %": 2.944, + "Num Positive per mm^2": 256.94 + } +} \ No newline at end of file diff --git a/614/TumorCenter_CD3_block10_x4_y9_patient614_1.json b/614/TumorCenter_CD3_block10_x4_y9_patient614_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0e8afc660f623eca47d782e2c0594c2f7962c4b9 --- /dev/null +++ b/614/TumorCenter_CD3_block10_x4_y9_patient614_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 22238.2, + "Num Detections": 17462, + "Num Negative": 17403, + "Num Positive": 59, + "Positive %": 0.3379, + "Num Positive per mm^2": 28.8 + } +} \ No newline at end of file diff --git a/614/TumorCenter_CD8_block10_x3_y9_patient614_0.json b/614/TumorCenter_CD8_block10_x3_y9_patient614_0.json new file mode 100644 index 0000000000000000000000000000000000000000..baf0e9c4473633ae6bb8705dcdd7cc16ea2cafdf --- /dev/null +++ b/614/TumorCenter_CD8_block10_x3_y9_patient614_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11419.0, + "Centroid Y µm": 23087.8, + "Num Detections": 20700, + "Num Negative": 20503, + "Num Positive": 197, + "Positive %": 0.9517, + "Num Positive per mm^2": 83.18 + } +} \ No newline at end of file diff --git a/614/TumorCenter_CD8_block10_x4_y9_patient614_1.json b/614/TumorCenter_CD8_block10_x4_y9_patient614_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1332660a9d077be10e29ab87fea7a63c5229a7e5 --- /dev/null +++ b/614/TumorCenter_CD8_block10_x4_y9_patient614_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 22962.8, + "Num Detections": 17662, + "Num Negative": 17626, + "Num Positive": 36, + "Positive %": 0.2038, + "Num Positive per mm^2": 17.0 + } +} \ No newline at end of file diff --git a/614/history_text.txt b/614/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..638cfec39f7d1edf0e1389cccd52d4b4603cf10f --- /dev/null +++ b/614/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT3 oropharyngeal carcinoma on the left. Neck status cN2b. Therefore above mentioned surgery indicated. \ No newline at end of file diff --git a/614/icd_codes.txt b/614/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9654f3ab501d7dec3f4e041ada7aa62ddbdab03 --- /dev/null +++ b/614/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Fossa tonsillaris[C09.0 ] Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/614/ops_codes.txt b/614/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15f4d9be6b82572b23a75a515218540e6b1e0d9c --- /dev/null +++ b/614/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Transplantat[5-296.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 R] Temporäre Tracheotomie[5-311.0 ] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 R] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Transorale partielle Zungenamputation mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Wechsel vaskuläres Implantat[5-394.3 ] \ No newline at end of file diff --git a/614/patient_clinical_data.json b/614/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9eb2ffdc84022c373e65b5a7074498a07bf09ff9 --- /dev/null +++ b/614/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 63, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/614/patient_pathological_data.json b/614/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f5050cc6e1706b1c2976656e7d2e6f97553aca3d --- /dev/null +++ b/614/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "614", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2a", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/614/surgery_description.txt b/614/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..283dbff71e1c0217cb51b6554ecf0ad5b36664d1 --- /dev/null +++ b/614/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheostomy, Defect coverage (Radial flap), Endoscopy diff --git a/614/surgery_report.txt b/614/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a72ae500737a0eb00b63ea949360355a0ee04040 --- /dev/null +++ b/614/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: The exophytic tumor is seen, which occupies the entire palatal arch and extends over the pharyngeal side wall to the base of the tongue, vallecula area and piriform sinus entrance. The tumor is first resected transorally: after reclination of the head, the Mc Ivor blade or retractor is inserted alternately. The tumor is resected on all sides with a safety margin of at least 1.5 cm to 2 cm. The entire palatal arch up to the tonsil on the right and the pharyngeal side wall including the parapharyngeal muscles are resected. Resection extends via the alvoelar ridge, which is exposed in the posterior part, to the posterior parts of the floor of the mouth and includes the base of the tongue, which is resected to about 30 %. This is followed by marginal samples from the palatal arch area, whereby the resection is carried out continuously from the upper to the lower mucosal border. Further marginal samples from the lateral alveolar ridge, from the base of the tongue and from the posterior area of the palatal arch and the transition to the upper oropharyngeal wall. In addition, a marginal sample from the soft tissues cranial as cranial basal. All marginal samples are healthy. Then repositioning for neck dissection and transcervical resection: First start with neck dissection on the left side: curved skin incision. Exposure of the sternocleidomastoid muscle anterior margin. Dissection of fat/lymph node preparation. Several larger lymph nodes palpable. These are laboriously dissected from the cervical vascular sheath. The facial vein is severed and cannot be preserved, likewise other veins around the lymph node conglomerate. Exposure of the omohyoid muscle, digastric muscle. Representation of the cervical vascular sheath, internal jugular vein, which can be preserved, internal and external carotid artery. Exposure of the vagus nerve and accessorius nerve as well as the hypoglossal nerve. All structures can be preserved. Removal of the lymph node conglomerate. Subsequent removal of the remains of the lateral neck preparation and preservation of the branches of the cervical plexus. Then removal of the remains of the medial neck preparation. Also removal of the submandibular gland and attached level I b lymph nodes. Careful preservation of the facial artery. This results in removal of the level I b to V lymph nodes. Neck dissection on the right side: This is carried out in the same way as on the left side, exposing and preserving the structures mentioned. Level II to IV evacuation is performed here, followed by careful hemostasis and irrigation on both sides. Then complete the tumor resection on the left side from the transcervical side: exposure of the external and internal carotid artery. Tumor resection is now completed. All parts of the wall are resected while sparing the large vessels. Caudally, the resection extends to the piriform sinus entrance, medially to the vallecula area. The epiglottis remains intact. This is followed by marginal samples of the pharyngeal wall medially caudally and in the caudal region. A marginal sample is also taken from the caudal wound bed. The entire tumor specimen is thread-marked and sent for examination together with the edge specimens, which are also thread-marked. Tumor specimen on all sides in healthy tissue, thus including the margin samples. R0 situation. Careful hemostasis. Now tracheostoma creation: small Kocher collar incision. Subsequent exposure of the infrahyoid muscles, spreading them. Exposure of the thyroid isthmus. This is clamped off, severed and supplied by means of puncture ligatures. Opening of the second/third intercartilaginous space, wide modified Björk flap, which is epithelized. Re-intubation. Now elevation of the radialis flap from the right side: marking of the flap after its dimensions have been measured transorally. Flap length almost 16 cm wide, 10 cm in the largest dimension. Mark the flap on the forearm. Then unwrap the arm and apply a tourniquet. Cutting around the flap from the ulna, later also from the radial side. Skin incision also curved towards the elbow. Subfascial lifting of the flap from distal to proximal. Proximally, the radial artery is removed and supplied with puncture ligatures. Outgoing vessels are clipped or supplied bipolar. Flap pedicle is identified and visualized under the brachioradialis. The superficial venous system is also visualized. Connection between the superficial and deep venous system in the crook of the elbow. This is visualized. A cephalic vein with two thick ends can be visualized. Walls very thick. Very thin accompanying veins on the radial artery, which are not capable of anastomosis. The interosseous artery was removed. Good reperfusion after opening the tourniquet. Longer reperfusion time. Subsequent removal of the flap. Veins are ligated. The outlet of the radial artery is treated by puncture ligation. The flap is then removed and heparin flushed. Vein lumen extremely narrow with very thick walls and equipped with valves. Therefore, shortening of the veins and ....................... division of the cephalic vein, then irrigation possible. Subsequent successive suturing of the flap into the defect according to its three-dimensional configuration using 3.0 Vicryl single-button sutures. Low-tension defect coverage. Complete closure. Then conditioning of the vessels. There is a small residual high-lying outlet on the internal jugular vein. However, the outlet is the appropriate size and is virtually located on the trunk of the internal jugular vein. The facial artery is selected for the arterial anastomosis. Here the lumen is too thin with a very thick muscular wall. Dissection up to the exit of the external carotid artery. The common trunk of the facial and lingual arteries can be visualized here. Anastomosis with the conditioned radial artery using 9.0 Ethilon sutures. After opening the clamp, good arterial flow, good venous return. As a venous anastomosis, an attempt is first made to anastomose a venous outlet from the flap pedicle with a high-set outlet very close to the internal jugular vein. This is not successful because the vessel wall is very thin and tears out. Therefore, first anastomosis of the second outlet from the flap stalk with the external jugular vein, which has already been partially anastomosed after ligation. This can be made pervious again after flushing with heparin. An anastomosis is created using a 2.5 mm coupler. Good venous return. Positive smear phenomenon. Subsequently, due to the unsatisfactory first anastomosis, creation of a second venous anastomosis. No further outlets were found on the internal jugular vein. This is therefore removed and connected to the second venous stump via a 2.5 mm coupler. Good venous return here too. Positive smear phenomenon. Overall flap now vital and well perfused. Careful hemostasis, irrigation of the wound area on both sides, closure of the wound on both sides with insertion of a Redon drain on the right and a flap on the left. An 8-gauge tracheostomy tube is inserted and sutured. The forearm is covered using a split-thickness skin graft from the right thigh. For this purpose, an appropriately sized split-thickness skin graft of maximum thickness is removed using the dermatome. Hydrogel dressing is applied to the thigh. Work the split skin into the defect. The cranial wound is closed in layers in the typical manner. Complete defect coverage. Application of a hydrogel-Mepilex dressing. Loosely applied compresses are placed on top. Absorbent cotton dressing. Fixation of the arm using a loosely applied Cramer splint. Further inspection of the flap. This is vital. The procedure is completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue heparin perfusor as started intraoperatively for 5 days at 500 units per hour. Please continue antibiotics started intraoperatively for 2 to 3 days postoperatively. Nutrition for 7 to 10 days via the inserted PEG tube. Flap control according to the scheme for 5 days. 30 degrees elevation. Overall cT3 to 4 min. cN2b oropharyngeal carcinoma on the left. Postoperative radiochemotherapy probably required. Please present the patient to the interdisciplinary tumor conference after receiving the final histology. \ No newline at end of file diff --git a/615/InvasionFront_CD3_block21_x1_y10_patient615_0.json b/615/InvasionFront_CD3_block21_x1_y10_patient615_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0dd02754801cdbc723af65f0510141e6b00b2bed --- /dev/null +++ b/615/InvasionFront_CD3_block21_x1_y10_patient615_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5547.1, + "Centroid Y µm": 35131.4, + "Num Detections": 19242, + "Num Negative": 19075, + "Num Positive": 167, + "Positive %": 0.8679, + "Num Positive per mm^2": 82.39 + } +} \ No newline at end of file diff --git a/615/InvasionFront_CD3_block21_x2_y10_patient615_1.json b/615/InvasionFront_CD3_block21_x2_y10_patient615_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eda28fd1163c44fac954000370cb3fe3608d5784 --- /dev/null +++ b/615/InvasionFront_CD3_block21_x2_y10_patient615_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7845.8, + "Centroid Y µm": 35281.3, + "Num Detections": 10187, + "Num Negative": 9445, + "Num Positive": 742, + "Positive %": 7.284, + "Num Positive per mm^2": 661.0 + } +} \ No newline at end of file diff --git a/615/InvasionFront_CD8_block21_x1_y10_patient615_0.json b/615/InvasionFront_CD8_block21_x1_y10_patient615_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fa10f9ec71031e672656fc43a882cc90c0c442c0 --- /dev/null +++ b/615/InvasionFront_CD8_block21_x1_y10_patient615_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 24612.0, + "Num Detections": 18181, + "Num Negative": 18153, + "Num Positive": 28, + "Positive %": 0.154, + "Num Positive per mm^2": 15.14 + } +} \ No newline at end of file diff --git a/615/InvasionFront_CD8_block21_x2_y10_patient615_1.json b/615/InvasionFront_CD8_block21_x2_y10_patient615_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e9a7527604bf38b89f10183991d549edfa7192d3 --- /dev/null +++ b/615/InvasionFront_CD8_block21_x2_y10_patient615_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 24562.0, + "Num Detections": 14545, + "Num Negative": 13895, + "Num Positive": 650, + "Positive %": 4.469, + "Num Positive per mm^2": 428.92 + } +} \ No newline at end of file diff --git a/615/TumorCenter_CD3_block21_x1_y10_patient615_0.json b/615/TumorCenter_CD3_block21_x1_y10_patient615_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0583459d2bf534e1f70d41e9611d0a183ec61c3 --- /dev/null +++ b/615/TumorCenter_CD3_block21_x1_y10_patient615_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3863.3, + "Centroid Y µm": 27673.7, + "Num Detections": 14237, + "Num Negative": 12444, + "Num Positive": 1793, + "Positive %": 12.59, + "Num Positive per mm^2": 1001.4 + } +} \ No newline at end of file diff --git a/615/TumorCenter_CD3_block21_x2_y10_patient615_1.json b/615/TumorCenter_CD3_block21_x2_y10_patient615_1.json new file mode 100644 index 0000000000000000000000000000000000000000..104c0155631168caa6c3ccdc59f46b39736d573b --- /dev/null +++ b/615/TumorCenter_CD3_block21_x2_y10_patient615_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6361.9, + "Centroid Y µm": 27618.3, + "Num Detections": 6576, + "Num Negative": 5743, + "Num Positive": 833, + "Positive %": 12.67, + "Num Positive per mm^2": 673.11 + } +} \ No newline at end of file diff --git a/615/TumorCenter_CD8_block21_x1_y10_patient615_0.json b/615/TumorCenter_CD8_block21_x1_y10_patient615_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e9897faba2b4b7816534d1fd1f6439da274093da --- /dev/null +++ b/615/TumorCenter_CD8_block21_x1_y10_patient615_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 39554.1, + "Num Detections": 21154, + "Num Negative": 19257, + "Num Positive": 1897, + "Positive %": 8.968, + "Num Positive per mm^2": 882.73 + } +} \ No newline at end of file diff --git a/615/TumorCenter_CD8_block21_x2_y10_patient615_1.json b/615/TumorCenter_CD8_block21_x2_y10_patient615_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5c191344e565f6c7b0195c6ed367c184e3c8f98b --- /dev/null +++ b/615/TumorCenter_CD8_block21_x2_y10_patient615_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8245.6, + "Centroid Y µm": 39479.1, + "Num Detections": 15101, + "Num Negative": 14548, + "Num Positive": 553, + "Positive %": 3.662, + "Num Positive per mm^2": 350.16 + } +} \ No newline at end of file diff --git a/615/history_text.txt b/615/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf572b588ab1672a7504b89d85b6fd36c0dc7d31 --- /dev/null +++ b/615/history_text.txt @@ -0,0 +1 @@ +A cT2 supraglottic laryngeal carcinoma was confirmed in the patient during a panendoscopy <2011>. CT showed uncertain demarcation towards the paraglottic space. Sonography showed a cN2a neck status on the left. \ No newline at end of file diff --git a/615/icd_codes.txt b/615/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/615/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/615/ops_codes.txt b/615/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3a858092ea3be0fc9690cb8cdfbae6915c3500fb --- /dev/null +++ b/615/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Endoskopische Laserresektion am Larynx[5-302.5 ] Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/615/patient_clinical_data.json b/615/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f62a2e2b5db7da81d868b6313c17179dc011c60d --- /dev/null +++ b/615/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/615/patient_pathological_data.json b/615/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4bbffd1047333f89a7524eb98842dc40c554a49e --- /dev/null +++ b/615/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "615", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 57, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/615/surgery_description.txt b/615/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c6bedda612f42c5406c79b0f760cc6b01da53c7 --- /dev/null +++ b/615/surgery_description.txt @@ -0,0 +1 @@ +Neck dissection and laser resection diff --git a/615/surgery_report.txt b/615/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..927461269015fe82fb50e2c101b16eb4e8feb88e --- /dev/null +++ b/615/surgery_report.txt @@ -0,0 +1 @@ +First, a pharyngo/laryngoscopy was performed. The exophytic tumor described above can be seen mainly in the area of the left fold, dorsal free ary, the tumor moves anteriorly to the laryngeal epglottis and from here circumscribed to the left fold. The vocal fold level itself is free. Growth just in front of the anterior commissure. If the tumor can be easily adjusted and palpated and is easy to move, laser resection is indicated. This is now performed by . The tumor is now successively excised from cranial to caudal. Beginning in the area of the laryngeal epiglottis, removal of the caudal epiglottis with removal of circumscribed pre-epiglottic fat. Resection of the tumor in several fragments to obtain an overview. Resection of the laryngeal part of the epiglottis. Now resection of the right pocket fold partially followed by resection of the complete left pocket fold, resection anterior to just above the anterior commissure. Macroscopic resection of the tumor clearly within the healthy tissue, safe conditions on all sides in depth during laser resection. Representative samples are now taken in the area of the supraglottis, the anterior commissure and the epiglottis. These are assessed as tumor-free in the frozen section diagnostics. Finally, dry wound conditions. Now turn to neck dissection on both sides: start with the right side. Injection of xylocaine with added adrenaline. Skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure and preservation of the external jugular vein and auricular nerve. Dissection of the transversus colli nerve. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the facial vein. Preservation of the facial vein and visualization of the digastric muscle. Release of the anterior neck preparation while sparing the superior thyroid artery, the cervical artery and the hypoglossal nerve. Free preparation of the internal jugular vein. Several lymph nodes measuring up to 1.5 cm, but not macroscopically suspicious, are visible in the area of the jugulo-facial angle. Exposure of the accessorius nerve. Clearing of the accessorius triangle and level V with careful protection of the cervical and caudal plexus without evidence of lymph leakage. Final wound inspection. Wound irrigation with Ringer's solution and turning to the opposite side. Same procedure here in principle. Injection of xylocaine with added adrenaline. Incision at the anterior edge of the sternocleidomastoid muscle. Cutting through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure and transection of the platysma. Creation of a platysmal flap. Exposure of the auricularis magnus nerve. An external jugular vein is not pronounced here. Exposure of the sternocleidomastoid muscle. A coarse mass measuring approx. 4 x 3 cm can now be easily palpated in levels II to III, which is still relatively easy to move, therefore the standard procedure continues. Dissection of the sternocleidomastoid muscle. Exclusion of an infiltration. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digasatric muscle. Visualization of the facial vein, which runs directly towards the metastasis, which is located cranial to the jugulofacial angle. Therefore, the facial vein is removed. Clearing out the anterior neck preparation while exposing and protecting the superior artery. The cervical artery moves directly towards the metastasis and is taken along. Exposure of the accessorius nerve. Subsequent free preparation of the internal jugular vein. Successive detachment from the metastasis. Exposure and dissection of the common carotid artery. The metastasis is directly overlying here, but is still separated from it by a broad layer of connective tissue. The metastasis extends as far as the hypoglossal nerve, but certainly does not infiltrate it. After free preparation of the internal jugular vein from the perivascular tissue, the metastasis can also be easily separated here. Overall, no evidence of perinodal growth, well encapsulated mass, furthermore several lymph nodes measuring up to approx. 2 cm in level II and III that are not necessarily suspicious. After complete visualization of the accessorius nerve, evacuation of the accessorius triangle and evacuation of level V with careful protection of the plexus branches and final check for lymph leakage. Subsequently dry conditions. Now a new discussion of the findings with . Plastic tracheostomy is now recommended, but no further measures are taken. Therefore, after wound irrigation of the left side, final wound inspection of both sides of the neck, insertion of a 10-gauge Redon drainage tube and careful two-layer wound closure. The tracheotomy was then performed. To do this, make a horizontal skin incision below the cricoid cartilage and cut through the skin and subcutaneous tissue. Exposure of the infrahyoid musculature, ligation of the anterior right jugular vein, exposure of the cricoid cartilage, exposure of the anterior surface of the trachea, the thyroid isthmus is relatively weak here and is coagulated in a bipolar fashion. Further visualization of the anterior surface of the trachea. Entry between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap, smoothing of the tracheostoma edges with the conchotome and subsequent suturing of the tracheostoma and subsequent problem-free reintubation on an 8 mm tracheoflex cannula. Finally, enoral wound inspection with the Kleinsasser tube. Here the wound conditions were clear with moderate glottic edema. Dry conditions on all sides, so the procedure was ended at this point. Conclusion: This was a cT2 cN2a G2 supraglottic laryngeal carcinoma on the left, which was resected intraoperatively R0 in conjunction with the resection and the representative marginal samples. Due to the clear lymph node metastasis, adjuvant therapy is certainly indicated postoperatively. Postoperative abstinence from food for at least 3 days, after which the patient can be given a liquid diet depending on swallowing function and, depending on the development of swallowing function, can be decannulated during the inpatient stay. The patient received intraoperative single-shot antibiotics with Unacid 3 g and a single dose of 250 mg SDH. \ No newline at end of file diff --git a/616/InvasionFront_CD3_block5_x1_y2_patient616_0.json b/616/InvasionFront_CD3_block5_x1_y2_patient616_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dfbe9cd010911d803db1495ce701a60adf2c6d8d --- /dev/null +++ b/616/InvasionFront_CD3_block5_x1_y2_patient616_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 5122.3, + "Num Detections": 16205, + "Num Negative": 15956, + "Num Positive": 249, + "Positive %": 1.537, + "Num Positive per mm^2": 104.78 + } +} \ No newline at end of file diff --git a/616/InvasionFront_CD3_block5_x2_y2_patient616_1.json b/616/InvasionFront_CD3_block5_x2_y2_patient616_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b491743af535707243aed91e6563dd2d57f4d4d6 --- /dev/null +++ b/616/InvasionFront_CD3_block5_x2_y2_patient616_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6781.0, + "Centroid Y µm": 5029.6, + "Num Detections": 19792, + "Num Negative": 19353, + "Num Positive": 439, + "Positive %": 2.218, + "Num Positive per mm^2": 197.89 + } +} \ No newline at end of file diff --git a/616/InvasionFront_CD8_block5_x1_y2_patient616_0.json b/616/InvasionFront_CD8_block5_x1_y2_patient616_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2d8af52cc746683ea27d4fab769b03e9f3994206 --- /dev/null +++ b/616/InvasionFront_CD8_block5_x1_y2_patient616_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 5397.1, + "Num Detections": 13274, + "Num Negative": 13253, + "Num Positive": 21, + "Positive %": 0.1582, + "Num Positive per mm^2": 10.27 + } +} \ No newline at end of file diff --git a/616/InvasionFront_CD8_block5_x2_y2_patient616_1.json b/616/InvasionFront_CD8_block5_x2_y2_patient616_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a9f4fe0c5c2302aee9da44c296f98d54dfc4746f --- /dev/null +++ b/616/InvasionFront_CD8_block5_x2_y2_patient616_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6646.5, + "Centroid Y µm": 5447.1, + "Num Detections": 19458, + "Num Negative": 19065, + "Num Positive": 393, + "Positive %": 2.02, + "Num Positive per mm^2": 188.85 + } +} \ No newline at end of file diff --git a/616/TumorCenter_CD3_block5_x1_y2_patient616_0.json b/616/TumorCenter_CD3_block5_x1_y2_patient616_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f2eef40972bbb35ec7e901520633cc70aac09554 --- /dev/null +++ b/616/TumorCenter_CD3_block5_x1_y2_patient616_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5771.9, + "Centroid Y µm": 4322.7, + "Num Detections": 20420, + "Num Negative": 19523, + "Num Positive": 897, + "Positive %": 4.393, + "Num Positive per mm^2": 342.4 + } +} \ No newline at end of file diff --git a/616/TumorCenter_CD3_block5_x2_y2_patient616_1.json b/616/TumorCenter_CD3_block5_x2_y2_patient616_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c942e9ce85a1b758f7dd71b3470d98f7cc62f98 --- /dev/null +++ b/616/TumorCenter_CD3_block5_x2_y2_patient616_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8270.6, + "Centroid Y µm": 4647.5, + "Num Detections": 18380, + "Num Negative": 17795, + "Num Positive": 585, + "Positive %": 3.183, + "Num Positive per mm^2": 234.08 + } +} \ No newline at end of file diff --git a/616/TumorCenter_CD8_block5_x1_y2_patient616_0.json b/616/TumorCenter_CD8_block5_x1_y2_patient616_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e2a75b701894947fe83aeaae93b6b53cea0f3592 --- /dev/null +++ b/616/TumorCenter_CD8_block5_x1_y2_patient616_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 4797.5, + "Num Detections": 21670, + "Num Negative": 21020, + "Num Positive": 650, + "Positive %": 3.0, + "Num Positive per mm^2": 242.04 + } +} \ No newline at end of file diff --git a/616/TumorCenter_CD8_block5_x2_y2_patient616_1.json b/616/TumorCenter_CD8_block5_x2_y2_patient616_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6971d48c9c6793bb65faf660255aa9cd1b310dba --- /dev/null +++ b/616/TumorCenter_CD8_block5_x2_y2_patient616_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 4972.4, + "Num Detections": 20233, + "Num Negative": 19918, + "Num Positive": 315, + "Positive %": 1.557, + "Num Positive per mm^2": 123.47 + } +} \ No newline at end of file diff --git a/616/history_text.txt b/616/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3e0bdc1958979708a8eda3e24b14481e676b5e80 --- /dev/null +++ b/616/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT3-4 oropharyngeal carcinoma. Therefore, the above-mentioned surgery was indicated after panendoscopy and CT with contrast medium. \ No newline at end of file diff --git a/616/icd_codes.txt b/616/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2405a3a2a1f520660c5cade89c8e5753d0d51ba7 --- /dev/null +++ b/616/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] \ No newline at end of file diff --git a/616/ops_codes.txt b/616/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c46889b145630c6fed06ae711e63aff91cfa903 --- /dev/null +++ b/616/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 L] Transplantat[5-296.14 ] Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Mikrochirurgische Technik (Zusatzkode)[5-984 ] \ No newline at end of file diff --git a/616/patient_clinical_data.json b/616/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dd6e054dff5fac4bf4e9d21daa596b609a115bc3 --- /dev/null +++ b/616/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/616/patient_pathological_data.json b/616/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7679346de8da0b44b51e627b535125f77f39467 --- /dev/null +++ b/616/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "616", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/616/surgery_description.txt b/616/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b893b4222acdeac8829045f3c316d7a622978d33 --- /dev/null +++ b/616/surgery_description.txt @@ -0,0 +1 @@ +Resection, Tracheotomy, PEG placement, Radical neck dissection, Free flap (Radial), Remmert flap diff --git a/616/surgery_report.txt b/616/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..bcaccf336d11fc4af65856316f6b14051f53eede --- /dev/null +++ b/616/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Sterile washing and draping of the neck area and performance of a tracheotomy by . Transverse skin incision for this, which can later be extended to form an apron flap. Exposure of the musculature. Splitting of the musculature in the midline. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Exposure of the anterior wall of the trachea. Entering the trachea between the second and third tracheal cartilages. Intubation onto an LE tube. Sterile washing and draping. Applying an apron flap in the usual manner and performing neck dissection in parallel on the right and left. Neck dissection on the left: This shows a huge metastasis in level II infiltrating the sternocleidomastoid muscle, the internal jugular vein, the hypoglossal nerve and the accessory nerve and parts of the cervical plexus as well as the marginal ramus of the oral branch and also parts of the lower pole of the parotid gland. First expose the anterior border of the sternocleidomastoid, then the omohyoid and the submandibular gland. Insertion of a blocker and exposure of the cervical vascular sheath. Then dissection of the cervical vascular sheath up to the tumor. Separation of the internal jugular vein. Removal of most of the sternocleidomastoid muscle. Separation of the digastric muscle, which is also infiltrated. Severing of the hypoglossus, which is also drawn into the metastasis. It can now be seen that the external parotid artery is also being drawn into the metastasis. Showing the internal carotid artery. This can be completely detached from the metastasis. Separation of the external carotid artery and removal of the neck specimen including the metastasis. The left side is therefore not suitable for performing a flap connection. Neck dissection on the right side, after creation of the apron flap: Dissection of the skin platysmal flap sharply with the scalpel. The jugular vein is exposed, ligated, cut and dissected further cranially and preserved. Dissection along the anterior edge of the sternocleidomastoid muscle in depth. The accessorius nerve is now exposed and spared. The accessor nerve is followed further cranially and the posterior belly of the digastric muscle is now also visible. Further medially, the submandibular gland can be seen, which is also easily visualized. The omohyoid muscle can be seen caudally. This shows the borders of the neck dissection. The cervical vascular sheath is visible in the depth below the neck preparation. The internal jugular vein is exposed from caudal to cranial. There is no injury to the structures here. The superior thyroid vein and facial vein are dissected and spared. Medial to the jugular vein, the common carotid artery, the external carotid artery, the vagus nerve and the cervical artery are exposed. The neck preparation is now detached in level II b. Level II a follows, sparing the accessorius nerve. Levels III/IV and V are also detached without difficulty. The plexus branches are visualized and specifically spared. No chyle fistula occurs caudally when the neck preparation is removed. The anterior neck preparation is now also exposed and dissected along the facial vein and the superior thyroid vein. Clinical cN0 neck status. The tumor is now resected from the transcervical area, but half of the hyoid bone must also be resected. The tumor is incised around the edge of the tongue, then in the base of the tongue, then dislocated cervically and the rest is dissected out here. The tumor is placed on a cork and then cut out as a whole. All edges are tumor-free. Moderate dysplasia at the base of the tongue. This is resected again with a corresponding margin sample. Both are sent for final histology. Then measurement of the defect and preparation of the radialis graft by . In the meantime, dissection of the vessels on the right side by . There is a well-branched facial vein and a slightly deeper outlet from the internal jugular vein that is well suited for venous vascular connection. The superior thyroid artery is then dissected, which could serve as an arterial vascular connection. Enter with the flexible gastroesophagoscope and insertion of the PEG through and . Entering with the gastroesophagoscope and, with air insufflation, pre-scanning into the stomach. Once in the stomach, endoscopy of the cardia after inversion of the endoscope. A spontaneous diaphanoscopy is now seen. A PEG is now placed in loco typico on the left paramedian anterior wall of the stomach using the suture pull-through method. This was performed without any problems. The patient received Unacid 3 g i.v. perioperatively. Measurement of the defect and the three-dimensional configuration. The resulting flap size is 14-15 x 10 cm, with one end becoming two-cornered. Now radial flap elevation. Mark the flap on the left forearm. Then first make an ulnar incision and extend the incision in the crook of the elbow. Elevation of the flap from the ulnar side. Then expose the superficial venous system and the connection to the deep venous system. Two cephalic veins can be dissected first. Cut around the flap radially. This is lifted subfascially as well as ulnarly, leaving tissue on the fascia. The lateral antebrachial cutaneous nerve is exposed and preserved. The radial artery is then exposed. After adequate clamping time, whereby the saturation here was constantly at 100 %, this is removed, cut and treated using 4.0 prolene sutures. Lift the flap subfascially along the pedicle. This must be separated by the brachioradialis muscle. Smaller vessels are clipped or supplied with bipolar. A confluence with two larger ends is also prepared in the area where the radial artery enters the brachial artery. This is removed, theoretically leaving two ends for the anastomosis. The veins are then removed and ligated proximally. The artery is removed and treated using 6.0 Vascufil single-button sutures. Removal of the flap and irrigation with heparin solution. A piece of split skin measuring 15 x 7 cm is easily removed from the right thigh using the dermatome. Due to the size of the defect, after demonstrating the findings on , another piece of skin is removed, measuring 8 x 8 cm from the thigh ............laterally. This is done without any problems. Dressing with starch powder and Mepilex. Suture the flap into the defect. The flap is successively sutured into the defect, sometimes with sutures. This is achieved without tension. Prior to this, infrahyoid muscles were pedicled at the left superior thyroid artery and lifted and mobilized as a Remmert flap while preserving the innervation as far as possible. After soft tissue preparation, the pedicle is pulled through under the mobilized Remmert flap and inserted into the right side of the neck. Here, the artery and three veins of the flap are conditioned first, a confluent vein and the two cephalic veins. The superior thyroid artery is then conditioned. This is incised slightly so that the lumen fits better with the lumen of the radial artery. Suturing using 8.0 Ethilon single-button sutures. After opening the clamps, very good arterial flow and good venous return. Conditioning of the veins. The thyroid vein is removed with two ends. The proximal ends are clipped. The two ends are each anastomosed with the confluent vein or one end of the cephalic veins with a 2.5 mm coupler after appropriate conditioning. After opening the clamps, good venous flow, positive smear phenomenon. The facial vein is then prepared. A small outlet is selected for the anastomosis with the second cephalic vein. This is also done using a 2.0 coupler. Here too, after opening the clamps, good venous return, positive smear phenomenon. The proximal end of the facial artery is first clipped and then ligated. Careful irrigation of the entire wound area and hemostasis are now performed. The Remmert flap is now inserted into the former tongue base area on the pedicle to create volume augmentation and fixed in place using several 3.0 Vicryl single button sutures. Subsequent irrigation and hemostasis. Inspection of the flap enorally, it is vital and well supplied with blood. The wound is now closed in layers, with insertion of a Redon drain on the left and two flaps on the right and epithelialization of the already created tracheostoma. For this purpose, the laryngectomy tube is removed and the size 8 tracheostomy tube is inserted and then fixed in place using sutures. A suture is placed on the right above the vascular pedicle at skin level to facilitate blood flow by means of Doppler monitoring. Inspection of the flap again. This is vital. The procedure is then completed without complications. The patient is ventilated and transferred to the intensive care unit. Please continue the intraoperative antibiotic treatment with Unacid for one week. Flap control according to the scheme for 5 days, clinically and by means of Doppler control every 2 hours. Nutrition via PEG tube for at least 10 days. Then X-ray pre-swallow and, if necessary, diet build-up. Overall cT3-4 oropharyngeal carcinoma on the left with cN2c status. Awaiting final histology and then presentation at the interdisciplinary tumor conference. Prolonged disturbance of swallowing function is to be expected. In this case, even after an unremarkable swallow, presentation to the voice and speech department or swallowing training on the ward. \ No newline at end of file diff --git a/617/InvasionFront_CD3_block18_x3_y9_patient617_0.json b/617/InvasionFront_CD3_block18_x3_y9_patient617_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7b3b529256c31eba0ce7627e3d230f44f6548bbc --- /dev/null +++ b/617/InvasionFront_CD3_block18_x3_y9_patient617_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10769.3, + "Centroid Y µm": 27310.5, + "Num Detections": 22214, + "Num Negative": 19948, + "Num Positive": 2266, + "Positive %": 10.2, + "Num Positive per mm^2": 930.82 + } +} \ No newline at end of file diff --git a/617/InvasionFront_CD3_block18_x4_y9_patient617_1.json b/617/InvasionFront_CD3_block18_x4_y9_patient617_1.json new file mode 100644 index 0000000000000000000000000000000000000000..663ae5de8f47537af1d191e8377c1bc304cfae15 --- /dev/null +++ b/617/InvasionFront_CD3_block18_x4_y9_patient617_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 27460.5, + "Num Detections": 15145, + "Num Negative": 14157, + "Num Positive": 988, + "Positive %": 6.524, + "Num Positive per mm^2": 538.18 + } +} \ No newline at end of file diff --git a/617/InvasionFront_CD8_block18_x3_y9_patient617_0.json b/617/InvasionFront_CD8_block18_x3_y9_patient617_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be5fb1548d9d9170d4e24b24ea9b8612612825a7 --- /dev/null +++ b/617/InvasionFront_CD8_block18_x3_y9_patient617_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 30034.1, + "Num Detections": 23765, + "Num Negative": 20982, + "Num Positive": 2783, + "Positive %": 11.71, + "Num Positive per mm^2": 1098.6 + } +} \ No newline at end of file diff --git a/617/InvasionFront_CD8_block18_x4_y9_patient617_1.json b/617/InvasionFront_CD8_block18_x4_y9_patient617_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0094debc3eba676895a28093c5bccc5aa5efa46f --- /dev/null +++ b/617/InvasionFront_CD8_block18_x4_y9_patient617_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 30084.1, + "Num Detections": 21460, + "Num Negative": 19027, + "Num Positive": 2433, + "Positive %": 11.34, + "Num Positive per mm^2": 1009.5 + } +} \ No newline at end of file diff --git a/617/TumorCenter_CD3_block18_x3_y9_patient617_0.json b/617/TumorCenter_CD3_block18_x3_y9_patient617_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f25a03190293744ca6d89b7cc5949de496740412 --- /dev/null +++ b/617/TumorCenter_CD3_block18_x3_y9_patient617_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 21838.4, + "Num Detections": 7686, + "Num Negative": 7329, + "Num Positive": 357, + "Positive %": 4.645, + "Num Positive per mm^2": 177.82 + } +} \ No newline at end of file diff --git a/617/TumorCenter_CD3_block18_x4_y9_patient617_1.json b/617/TumorCenter_CD3_block18_x4_y9_patient617_1.json new file mode 100644 index 0000000000000000000000000000000000000000..08233f08d89015368c4d12d8edecc6f715dac188 --- /dev/null +++ b/617/TumorCenter_CD3_block18_x4_y9_patient617_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13130.5, + "Centroid Y µm": 21888.4, + "Num Detections": 14614, + "Num Negative": 13587, + "Num Positive": 1027, + "Positive %": 7.028, + "Num Positive per mm^2": 467.17 + } +} \ No newline at end of file diff --git a/617/TumorCenter_CD8_block18_x3_y9_patient617_0.json b/617/TumorCenter_CD8_block18_x3_y9_patient617_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac3d83911bf1e163a0e0289109a84c0958fc87d9 --- /dev/null +++ b/617/TumorCenter_CD8_block18_x3_y9_patient617_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10544.4, + "Centroid Y µm": 22812.9, + "Num Detections": 17956, + "Num Negative": 16761, + "Num Positive": 1195, + "Positive %": 6.655, + "Num Positive per mm^2": 519.04 + } +} \ No newline at end of file diff --git a/617/TumorCenter_CD8_block18_x4_y9_patient617_1.json b/617/TumorCenter_CD8_block18_x4_y9_patient617_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72644f17e21dce95bd9dcfef1548d44249248173 --- /dev/null +++ b/617/TumorCenter_CD8_block18_x4_y9_patient617_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13068.1, + "Centroid Y µm": 22887.9, + "Num Detections": 20675, + "Num Negative": 17758, + "Num Positive": 2917, + "Positive %": 14.11, + "Num Positive per mm^2": 1170.1 + } +} \ No newline at end of file diff --git a/617/history_text.txt b/617/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ccfbb926051d05e3cbd66ae06d5b00dfd94c6d4 --- /dev/null +++ b/617/history_text.txt @@ -0,0 +1 @@ +Patient with right supraglottic laryngeal carcinoma, cT4 cN2c cM0. CT-graphic thyroid cartilage infiltration. The patient opted for surgical treatment. \ No newline at end of file diff --git a/617/icd_codes.txt b/617/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/617/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/617/ops_codes.txt b/617/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..87fb0a430c1090068f4554e766e66813c2becff3 --- /dev/null +++ b/617/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Tracheobronchoskopie[1-620.x ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Sonstige Laryngektomie mit Pharyngektomie[5-303.1x ] Einlegen oder Wechsel einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/617/patient_clinical_data.json b/617/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6e3f6ee8afc197d876309dd36efdd57514c0acdc --- /dev/null +++ b/617/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/617/patient_pathological_data.json b/617/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b0a38e8784f48b292f550aa921c023a7a734133c --- /dev/null +++ b/617/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "617", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/617/surgery_description.txt b/617/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e9a295fa09d8b12313c5b7cf17d5f8780c87b290 --- /dev/null +++ b/617/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection diff --git a/617/surgery_report.txt b/617/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5f87e66007956ffdcf125672aecc05f353963845 --- /dev/null +++ b/617/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. Nasal intubation. Placement of a nasogastric tube. Abjodation and draping. Apron flap placement with inferior border at tracheostoma level. Exposure of the sternocleidomastoid muscle on both sides. Beginning with the neck dissection on the left side. Exposure of the inner edge of the sternocleidomastoid muscle. Visualization of the accessorius nerve. Finding the digastric muscle. Dissecting the omohyoid muscle. Dissection of the vascular nerve sheath and development of the lateral neck preparation. Exposure and protection of the hypoglossal nerve. Opening of the cervical vascular sheath. Exposure of the common, internal and external carotid artery. Visualization of the vagus. Development of the medial neck preparation, which remains connected to the later laryngectomy preparation including the infrahyoid musculature. Separation of the superior laryngeal artery. Development of the intrahyoid musculature and deposition on its inferior part suprasternal. Raising the infrahyoid musculature. Exposure of the thyroid capsule. Undermining of the isthmus. Severing of the isthmus. Re-perforation of the thyroid lobe margins. Exposure of the anterior surface of the trachea. Transition to neck dissection on the right side. Exposure of the inside of the sternocleidomastoid muscle. Exposure and visualization of the accessorius nerve. Exposure of the digastric muscle, following it to its anterior end at the hyoid bone. Exposure of the omohyoid muscle. Exposure of the cervical vascular sheath and development of the lateral neck preparation. Exposure of the internal and external common carotid artery. Exposure and visualization of the vagus nerve. Separation of the superior laryngeal artery. Now cut through the omohyoid muscle on both sides. Separation of the suprahyoid muscles at the level of the hyoid bone. Expose the hyoid bone and separate the ligaments from the lesser horn of the hyoid bone. Entering the pre-epiglottic fatty tissue and resection of the pre-epiglottic space together with the epiglottis. Release of the prelaryngeal musculature. Careful release of the sinus piriformis mucosa primarily on the left side. Careful resection on the right side, maintaining a safety margin of one cm, and development of the tumor, which has spread to the medial wall and into the anterior region of the piriform sinus on the right side. Now proceed to tracheotomy. Horizontal incision superior and inferior to the third tracheal clasp. Longitudinal division of the same. Fixation of the tracheal part with inferior stoma sutures. Separation of the cricoid cartilage, forming a mucosal flap lining the posterior edge of the cricoid cartilage. Finally, the complete larynx is removed. The mucosal flap just mentioned closes the still standing tracheal cylinder cranially. Removal of marginal samples and sending for frozen section. All frozen sections are tumor-free. Continuous inverting primary pharyngeal suture running vertically and cranially horizontally. Adapting sutures of the overlying pharyngeal musculature. Myotomy of the constrictor muscles before pharyngeal suture. Furthermore, placement of a Provox voice prosthesis in the typical manner without complications. Suturing of the tracheostoma. The split tracheal clips are sewn into the upper edge of the skin from the inside. Creation of Redon drains on both sides of the neck. Subcutaneous suture. Cutaneous suture. Re-intubation onto a 10 mm tracheal cannula. Completion of the procedure with no indication of complications. Conclusion: Complete laryngectomy and neck dissection on both sides with lymph nodes definitely clinically conspicuous on the right side. Please leave the nasogastric tube in place for 10 days and then take an X-ray before starting food. Antibiotic cover for 5 days with Unacid. Adjuvant treatment after pathological result. \ No newline at end of file diff --git a/618/InvasionFront_CD3_block20_x5_y5_patient618_0.json b/618/InvasionFront_CD3_block20_x5_y5_patient618_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1f0dcb33dd4963e8ae2bf10436fa21239b49d643 --- /dev/null +++ b/618/InvasionFront_CD3_block20_x5_y5_patient618_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17540.7, + "Centroid Y µm": 12818.2, + "Num Detections": 26289, + "Num Negative": 24555, + "Num Positive": 1734, + "Positive %": 6.596, + "Num Positive per mm^2": 636.4 + } +} \ No newline at end of file diff --git a/618/InvasionFront_CD3_block20_x6_y5_patient618_1.json b/618/InvasionFront_CD3_block20_x6_y5_patient618_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b374bb2d52aad88ef3d7f4edd1bf0208878e8136 --- /dev/null +++ b/618/InvasionFront_CD3_block20_x6_y5_patient618_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20189.3, + "Centroid Y µm": 13068.1, + "Num Detections": 21241, + "Num Negative": 20576, + "Num Positive": 665, + "Positive %": 3.131, + "Num Positive per mm^2": 265.51 + } +} \ No newline at end of file diff --git a/618/InvasionFront_CD8_block20_x5_y5_patient618_0.json b/618/InvasionFront_CD8_block20_x5_y5_patient618_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de2b3bd99b2129a1e4ca6e68f0366268e7eb9a02 --- /dev/null +++ b/618/InvasionFront_CD8_block20_x5_y5_patient618_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16716.1, + "Centroid Y µm": 12493.4, + "Num Detections": 18870, + "Num Negative": 18036, + "Num Positive": 834, + "Positive %": 4.42, + "Num Positive per mm^2": 406.6 + } +} \ No newline at end of file diff --git a/618/InvasionFront_CD8_block20_x6_y5_patient618_1.json b/618/InvasionFront_CD8_block20_x6_y5_patient618_1.json new file mode 100644 index 0000000000000000000000000000000000000000..877895d32d4c1f7882a30a37211ba0b9c81653dc --- /dev/null +++ b/618/InvasionFront_CD8_block20_x6_y5_patient618_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19364.7, + "Centroid Y µm": 12343.5, + "Num Detections": 20975, + "Num Negative": 20783, + "Num Positive": 192, + "Positive %": 0.9154, + "Num Positive per mm^2": 81.07 + } +} \ No newline at end of file diff --git a/618/TumorCenter_CD3_block20_x5_y5_patient618_0.json b/618/TumorCenter_CD3_block20_x5_y5_patient618_0.json new file mode 100644 index 0000000000000000000000000000000000000000..210fb74d8fe609fd2ab76563f008f63a9c19e6cc --- /dev/null +++ b/618/TumorCenter_CD3_block20_x5_y5_patient618_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16226.2, + "Centroid Y µm": 11737.3, + "Num Detections": 11907, + "Num Negative": 10873, + "Num Positive": 1034, + "Positive %": 8.684, + "Num Positive per mm^2": 653.5 + } +} \ No newline at end of file diff --git a/618/TumorCenter_CD3_block20_x6_y5_patient618_1.json b/618/TumorCenter_CD3_block20_x6_y5_patient618_1.json new file mode 100644 index 0000000000000000000000000000000000000000..db248d6ffc7d1fb7945e7ac7ad99a8bece0e6995 --- /dev/null +++ b/618/TumorCenter_CD3_block20_x6_y5_patient618_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18838.3, + "Centroid Y µm": 11857.6, + "Num Detections": 16753, + "Num Negative": 15864, + "Num Positive": 889, + "Positive %": 5.307, + "Num Positive per mm^2": 439.66 + } +} \ No newline at end of file diff --git a/618/TumorCenter_CD8_block20_x5_y5_patient618_0.json b/618/TumorCenter_CD8_block20_x5_y5_patient618_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6f847fc926b7ad72ed0a92ca71540663df5c080 --- /dev/null +++ b/618/TumorCenter_CD8_block20_x5_y5_patient618_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15691.7, + "Centroid Y µm": 12243.5, + "Num Detections": 15032, + "Num Negative": 13590, + "Num Positive": 1442, + "Positive %": 9.593, + "Num Positive per mm^2": 783.7 + } +} \ No newline at end of file diff --git a/618/TumorCenter_CD8_block20_x6_y5_patient618_1.json b/618/TumorCenter_CD8_block20_x6_y5_patient618_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4602247d399727fabf06b0ff3e285dc4b6b4aa18 --- /dev/null +++ b/618/TumorCenter_CD8_block20_x6_y5_patient618_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18315.3, + "Centroid Y µm": 11993.6, + "Num Detections": 19116, + "Num Negative": 18121, + "Num Positive": 995, + "Positive %": 5.205, + "Num Positive per mm^2": 424.79 + } +} \ No newline at end of file diff --git a/618/history_text.txt b/618/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a341f9068a407e205cb867a0524e65af3c91101 --- /dev/null +++ b/618/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed laryngeal carcinoma on the right. Preoperatively, the tumor is exophytic in the area of the right vocal fold extending to the anterior commissure. Right vocal fold immobile to stationary. CT shows no infiltration of the cartilage. Therefore, attempt at surgery and laser resection from the inside and possibly also from the outside. \ No newline at end of file diff --git a/618/icd_codes.txt b/618/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/618/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/618/ops_codes.txt b/618/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b281b4a7d1afa783dfce7ccb77d351e2a1ed5af1 --- /dev/null +++ b/618/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/618/patient_clinical_data.json b/618/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4ba4754302b6145fcac880e4ff7a8dbdf18e547e --- /dev/null +++ b/618/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 45, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/618/patient_pathological_data.json b/618/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e81e6d530366063d2c8223cc2fde2b8edbc45729 --- /dev/null +++ b/618/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "618", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/618/surgery_description.txt b/618/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..87d61b66323b7e3792f00b52b99f494b2dd737aa --- /dev/null +++ b/618/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Tracheotomy diff --git a/618/surgery_report.txt b/618/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8c3f8f41741eedfe40bff2cd464513d63be88d46 --- /dev/null +++ b/618/surgery_report.txt @@ -0,0 +1 @@ +First position the head. Insert the mouthguard. Enter with the Kleinsasser tube size C, later also B. Exposure of the tumor. The tumor extends to the arytenoid cartilage. Large exophytic tumor extending into the morgagnous ventricle and subglottic as well as extending to the anterior commissure. Decision to attempt laser resection. Tumor is successively removed macroscopically in the healthy tissue using the piecemeal technique. In the resectate, the arytenoid cartilage as well as the pocket fold and the entire soft tissue up to the cartilage are removed laterally. Anteriorly with resection of the vocal fold on the front left and the supraglottic soft tissue up to the cartilage. Exposure of the cartilage below with resection of the conus elasticus. The resection extends caudally to the upper edge of the cricoid cartilage. Subsequently, removal of marginal samples on the right in the area of the arytenoid cartilage, whereby a large part of the arytenoid cartilage still remaining in situ is removed except for a remnant lying transversely to the upper back. Caudal removal of the mucosal margin sample at the edge of the cricoid cartilage, is immediately caudal on the right. Remains of the paraglottic muscle tissue or soft tissue above the cricoid cartilage are sent in as a basal marginal sample. Above this, exposed cartilage freed from the perichondrium, above this large soft tissue sample supraglottic on the right. Subsequently, extended supraglottic marginal sample in the area of the anterior commissure. Below this, exposed cartilage and below this, extensive soft tissue margin sample from the area of the conus elasticus or ligamentum chronicum down to the subcutaneous tissue. Careful hemostasis, especially in the area of the transverse artery. Dorsal hemostasis in the area of the inferior laryngeal artery, which could be visualized. Left anterior margin sample from the vocal fold and from the conus elasticus of the left vocal fold. Here too, the edge sample was taken up to the cartilage. Subsequent careful hemostasis. All marginal samples are tumor-free in the frozen section. Due to the extent of the resection, tracheotomy is now indicated. Repositioning of the patient. Skin disinfection. Injection of 5 ml Ultracaine 1% with adrenaline. Skin incision as required. Dissection through subcutaneous tissue to the infrahyoid musculature. This is split. Subsequent exposure of the thyroid isthmus, which is very small, it is supplied with bipolar and severed. Exposure of the trachea and removal of the soft tissue. Enter the 2nd/3rd intercartilaginous space. Exposure of a wide modified Björk flap. Epithelialization of this in a typical manner with Ethibond sutures. Tension-free tracheostoma. Subsequent insertion of an 8 mm tacheal cannula without any problems. Ventilation without any problems. Finally, the larynx was checked again. No significant active bleeding here. Minor mucosal bleeding was again treated monopolarly. Finally, another gastric tube was inserted. Regular position check. The procedure was completed without complications. Overall cT2-3 laryngeal carcinoma resected using the piecemeal technique and R0 resection confirmed using representative and sufficient marginal samples. Due to the extent of the carcinoma, it is essential to plan a follow-up MLE in 8 to 12 weeks. \ No newline at end of file diff --git a/619/InvasionFront_CD8_block3_x5_y11_patient619_0.json b/619/InvasionFront_CD8_block3_x5_y11_patient619_0.json new file mode 100644 index 0000000000000000000000000000000000000000..45aa4576d412e3cf7a112d8fa650a068abfd734d --- /dev/null +++ b/619/InvasionFront_CD8_block3_x5_y11_patient619_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17265.9, + "Centroid Y µm": 27210.6, + "Num Detections": 20949, + "Num Negative": 14120, + "Num Positive": 6829, + "Positive %": 32.6, + "Num Positive per mm^2": 2806.9 + } +} \ No newline at end of file diff --git a/619/InvasionFront_CD8_block3_x6_y11_patient619_1.json b/619/InvasionFront_CD8_block3_x6_y11_patient619_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e9089e505f0484728348edc5ec2193e0773fd7d7 --- /dev/null +++ b/619/InvasionFront_CD8_block3_x6_y11_patient619_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19889.5, + "Centroid Y µm": 27235.6, + "Num Detections": 23137, + "Num Negative": 16852, + "Num Positive": 6285, + "Positive %": 27.16, + "Num Positive per mm^2": 2554.8 + } +} \ No newline at end of file diff --git a/619/TumorCenter_CD3_block3_x5_y11_patient619_0.json b/619/TumorCenter_CD3_block3_x5_y11_patient619_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a58804aa61ced3050492108278e0ce67e12c198e --- /dev/null +++ b/619/TumorCenter_CD3_block3_x5_y11_patient619_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15373.1, + "Centroid Y µm": 33826.1, + "Num Detections": 18248, + "Num Negative": 8825, + "Num Positive": 9423, + "Positive %": 51.64, + "Num Positive per mm^2": 3932.2 + } +} \ No newline at end of file diff --git a/619/TumorCenter_CD3_block3_x6_y11_patient619_1.json b/619/TumorCenter_CD3_block3_x6_y11_patient619_1.json new file mode 100644 index 0000000000000000000000000000000000000000..589f91d97c79a3a7caa3b63bb129e98c6898b5f3 --- /dev/null +++ b/619/TumorCenter_CD3_block3_x6_y11_patient619_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17865.5, + "Centroid Y µm": 34032.0, + "Num Detections": 18029, + "Num Negative": 10425, + "Num Positive": 7604, + "Positive %": 42.18, + "Num Positive per mm^2": 3002.6 + } +} \ No newline at end of file diff --git a/619/TumorCenter_CD8_block3_x5_y11_patient619_0.json b/619/TumorCenter_CD8_block3_x5_y11_patient619_0.json new file mode 100644 index 0000000000000000000000000000000000000000..db0ded7464552590caa8c9a3c4613521a2c58e53 --- /dev/null +++ b/619/TumorCenter_CD8_block3_x5_y11_patient619_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 28884.7, + "Num Detections": 18819, + "Num Negative": 11111, + "Num Positive": 7708, + "Positive %": 40.96, + "Num Positive per mm^2": 3226.5 + } +} \ No newline at end of file diff --git a/619/TumorCenter_CD8_block3_x6_y11_patient619_1.json b/619/TumorCenter_CD8_block3_x6_y11_patient619_1.json new file mode 100644 index 0000000000000000000000000000000000000000..841ef59a64359929458e8ba48ae6b99cdf6d4f83 --- /dev/null +++ b/619/TumorCenter_CD8_block3_x6_y11_patient619_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 29084.6, + "Num Detections": 17926, + "Num Negative": 12234, + "Num Positive": 5692, + "Positive %": 31.75, + "Num Positive per mm^2": 2495.2 + } +} \ No newline at end of file diff --git a/619/history_text.txt b/619/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b65647e21e5ed8ac40f1978d8f34f4b01243ef06 --- /dev/null +++ b/619/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Histologically confirmed malignancy in the area of the left tonsil. In addition, parapharyngeal localized lymph node. Enoral tumor resection performed first. \ No newline at end of file diff --git a/619/icd_codes.txt b/619/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa6097eacf18ae8aea8260bca82cce6b0a31ad0c --- /dev/null +++ b/619/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/619/ops_codes.txt b/619/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..acb6deaf380f2fbbd2ddad2380a551601396138b --- /dev/null +++ b/619/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/619/patient_clinical_data.json b/619/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7af79900dc03134775f8cd3cba4dab792e950cc7 --- /dev/null +++ b/619/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/619/patient_pathological_data.json b/619/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9d2affb492e0cea22000a98b0db5531547e4f35c --- /dev/null +++ b/619/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "619", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 14, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/619/surgery_description.txt b/619/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..20e8af3c7aecdf622d08b3e27e85e1c2b09cca38 --- /dev/null +++ b/619/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection for tonsillar carcinoma diff --git a/619/surgery_report.txt b/619/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a6859266ddc60140304aeac350d085f3eb400b8 --- /dev/null +++ b/619/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Then insertion of the tonsil plug. Exposure of the left tonsil lobe. Wide incision of the tumorous process in the area of the left tonsil lobe while protecting the posterior palatal arch. Careful dissection in the area of the musculature and dissection up to the base of the tongue. As far as can be assessed intraoperatively, the resection is carried out in healthy tissue on all sides. The posterior palatal arch can be preserved. Careful hemostasis. Removal of the tumor in the area of the base of the tongue. Marking of the specimen. Removal of marginal samples in clinically unremarkable resection conditions. Careful hemostasis. Insertion of a gastric tube. Check the wound bed again. Dry conditions. Final consultation with the anesthetist. Due to the extensive resection and the localization of the cervical lymph nodes, a simultaneous neck dissection is not performed. The neck dissection is performed in two stages. \ No newline at end of file diff --git a/620/InvasionFront_CD3_block11_x5_y1_patient620_0.json b/620/InvasionFront_CD3_block11_x5_y1_patient620_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6628129ad9ffcb4fdb507790287a60ca1e18a93 --- /dev/null +++ b/620/InvasionFront_CD3_block11_x5_y1_patient620_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 2498.7, + "Num Detections": 19799, + "Num Negative": 18892, + "Num Positive": 907, + "Positive %": 4.581, + "Num Positive per mm^2": 391.66 + } +} \ No newline at end of file diff --git a/620/InvasionFront_CD3_block11_x6_y1_patient620_1.json b/620/InvasionFront_CD3_block11_x6_y1_patient620_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a6ec43df7d3573a7fb923dbdadf1fbb947139457 --- /dev/null +++ b/620/InvasionFront_CD3_block11_x6_y1_patient620_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18015.5, + "Centroid Y µm": 2648.6, + "Num Detections": 23640, + "Num Negative": 22571, + "Num Positive": 1069, + "Positive %": 4.522, + "Num Positive per mm^2": 443.3 + } +} \ No newline at end of file diff --git a/620/InvasionFront_CD8_block11_x5_y1_patient620_0.json b/620/InvasionFront_CD8_block11_x5_y1_patient620_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7fab040af0ce3178f4f55a4217041c4e7f8036e2 --- /dev/null +++ b/620/InvasionFront_CD8_block11_x5_y1_patient620_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19002.5, + "Centroid Y µm": 12931.9, + "Num Detections": 9928, + "Num Negative": 9580, + "Num Positive": 348, + "Positive %": 3.505, + "Num Positive per mm^2": 285.53 + } +} \ No newline at end of file diff --git a/620/InvasionFront_CD8_block11_x6_y1_patient620_1.json b/620/InvasionFront_CD8_block11_x6_y1_patient620_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2dc986b0dfff2bab162387c6ac9a2fa2b23676db --- /dev/null +++ b/620/InvasionFront_CD8_block11_x6_y1_patient620_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21558.3, + "Centroid Y µm": 13147.2, + "Num Detections": 16840, + "Num Negative": 16762, + "Num Positive": 78, + "Positive %": 0.4632, + "Num Positive per mm^2": 44.08 + } +} \ No newline at end of file diff --git a/620/TumorCenter_CD3_block11_x5_y1_patient620_0.json b/620/TumorCenter_CD3_block11_x5_y1_patient620_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9fde5f0001b1bc14f97f7d85fdbe6d232c1ca327 --- /dev/null +++ b/620/TumorCenter_CD3_block11_x5_y1_patient620_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19798.9, + "Centroid Y µm": 2684.9, + "Num Detections": 11762, + "Num Negative": 11250, + "Num Positive": 512, + "Positive %": 4.353, + "Num Positive per mm^2": 412.6 + } +} \ No newline at end of file diff --git a/620/TumorCenter_CD3_block11_x6_y1_patient620_1.json b/620/TumorCenter_CD3_block11_x6_y1_patient620_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ad2a21bc7105f389f4bc8623cc9eb68ec6e78c4 --- /dev/null +++ b/620/TumorCenter_CD3_block11_x6_y1_patient620_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 22211.7, + "Centroid Y µm": 2884.8, + "Num Detections": 21279, + "Num Negative": 20811, + "Num Positive": 468, + "Positive %": 2.199, + "Num Positive per mm^2": 198.95 + } +} \ No newline at end of file diff --git a/620/TumorCenter_CD8_block11_x5_y1_patient620_0.json b/620/TumorCenter_CD8_block11_x5_y1_patient620_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2d8ad19649623d64e921fa5c9428026a2711808c --- /dev/null +++ b/620/TumorCenter_CD8_block11_x5_y1_patient620_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17140.9, + "Centroid Y µm": 2648.6, + "Num Detections": 15034, + "Num Negative": 13272, + "Num Positive": 1762, + "Positive %": 11.72, + "Num Positive per mm^2": 1126.8 + } +} \ No newline at end of file diff --git a/620/TumorCenter_CD8_block11_x6_y1_patient620_1.json b/620/TumorCenter_CD8_block11_x6_y1_patient620_1.json new file mode 100644 index 0000000000000000000000000000000000000000..031aed2465063c563369da6ecdb0df15326f574a --- /dev/null +++ b/620/TumorCenter_CD8_block11_x6_y1_patient620_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 2523.7, + "Num Detections": 20372, + "Num Negative": 19314, + "Num Positive": 1058, + "Positive %": 5.193, + "Num Positive per mm^2": 469.95 + } +} \ No newline at end of file diff --git a/620/history_text.txt b/620/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6293f53680554ef9fe6c31e1c1c67e4da1288280 --- /dev/null +++ b/620/history_text.txt @@ -0,0 +1 @@ +Histologically, a squamous cell carcinoma of the left tonsil was already detected in the patient. This spreads relatively far into the parapharyngeal soft tissues. The above plan is therefore adopted. \ No newline at end of file diff --git a/620/icd_codes.txt b/620/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed4aa87497852c75f601688357848e31931e81a2 --- /dev/null +++ b/620/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/620/ops_codes.txt b/620/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aee04c9f6b1621cb57a7ac5260844259291bfdec --- /dev/null +++ b/620/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Transplantat[5-295.04 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut kleinflächig Empfängerstelle Unterarm[5-902.28 L] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] \ No newline at end of file diff --git a/620/patient_clinical_data.json b/620/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fd824ff216baaa895e82a2444d2dbbe0b88af089 --- /dev/null +++ b/620/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 67, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/620/patient_pathological_data.json b/620/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ae965b841ac948f60da8d68a7d206713f4c657c1 --- /dev/null +++ b/620/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "620", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Lymphoepithelial", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/620/surgery_description.txt b/620/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..69718c8140a2edfe515053688a36da7c888d36bd --- /dev/null +++ b/620/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Flap coverage (Radial), Tracheotomy, PEG placement diff --git a/620/surgery_report.txt b/620/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..52e71d8c4c5f26263e7623d0c014479e4b2e6eda --- /dev/null +++ b/620/surgery_report.txt @@ -0,0 +1 @@ +: Before intubation, perform another tracheobronchoscopy: insertion of the 0° optics. Unobtrusive conditions in the area of the trachea and bifurcation as well as the visible main bronchi. Intubation by the surgeon and finally performance of an esophagoscopy with gastroscopy and insertion of a PEG using the thread pull-through method in the usual manner. This was successful without any problems. Good diaphanoscopy. Subsequent endoscopy of the hypopharynx and larynx. Inconspicuous conditions here. The previously described tonsil tumor is seen on the left. First of all, detailed consultation with the anesthesiologist regarding the further procedure. Then sterile wound covering. Carry out the neck dissection on the left: Skin incision on the anterior edge of the sternocleidomastoid muscle. Very pronounced metastases in this area. Dissection of the external jugular vein, which remains intact. Then dissection in depth. A metastasis is found directly there. The metastasis is cut around with part of the muscle. Dissection of the internal jugular vein in depth, which is later removed and ligated as part of the radical operation. Now the vagus nerve, the hypoglossal nerve, the external and internal carotid arteries are dissected in depth. Dissection of the posterior digastric venter muscle and very careful clearing of the accessorius triangle after exposing the nerve. Dissection caudally and anteriorly. Complete the neck dissection. Removal of the capsule of the submandibular gland. Now counter-resection from the transoral side. To do this, cut around the tumor in the area of the tonsil, passing over to the base of the tongue. Deposition of the tumor clinically in healthy tissue. Removal of the tumor specimen and removal of circular marginal samples. The marginal specimen is found to be still tumor-infested in depth and laterally in the frozen section. Due to this extension, a counter-resection must be performed from the cervical side. Now further dissection in depth. Protection of the carotid artery. Resection of the pharyngeal musculature extending to the base of the tongue and removal of the entire tonsil bed. Clinical incision far into the healthy tissue. Smaller branches of the external carotid artery are also cut and severed and the lingual nerve, which also runs deep through the area still affected by the tumor, is severed. Again, marginal samples are taken, which are now found to be tumor-free. The defect is now larger and can only be covered with a radial flap. Now first perform the neck dissection on the right side: To do this, make a skin incision on the anterior edge of the sternocleidomastoid muscle. Expose the muscle. Dissection in depth. Dissection of the internal jugular vein, facial vein, vagus nerve, hypoglossal nerve and accessorius nerve. Dissection of the external and internal carotid artery. Dissection of the posterior digastric venter muscle. Dissection of the accessorius triangle from caudal to supraclavicular. Dissection of the omohyoid muscle and removal of the lymph nodes from the anterior neck preparation and the venous angle while sparing the entire structures. Removal of the capsule of the submandibular gland. Extensive hemostasis with H2O2 swabs and bipolar coagulation. No more bleeding. Insertion of a Redon drainage. Subcutaneous suture, skin suture and wound dressing. Finally, perform a tracheotomy: make a longitudinal and star-shaped incision over the jugulum. Dissection of the subcutaneous tissue. Exposure of the infrahyoid musculature. Dissection of the thyroid isthmus. Exposure of the trachea. Insertion between the 2nd and 3rd tracheal cartilage. Formation of a Björk flap and creation of an epithelialized tracheostoma. After tumor resection, a radial flap is now inserted. See the surgical report . : After creation of the R0 resection using combined transoral enoral resection, defect coverage using a microvascularly pedicled radial flap from the left side: First removal of the forearm flap: Defect was previously measured, flap dimension with three-dimensional, multi-lobed dimensions 10 x 8 cm with regard to size expansion. Flap is recorded on the forearm. Subsequent application of a tourniquet. The flap is then trimmed and the skin incision made in the direction of the elbow bend. Lift the flap subfascially from the ulna to the radial side. Radial inclusion of the superficial venous system. This is integrated into the pedicle with subcutaneous tissue up to the crook of the elbow. Forearm mucosa nevertheless remains supplied with subcutaneous tissue. The radial artery and accompanying veins are removed, clamped and supplied distally and proximally using 4.0 Prolene puncture ligatures. The flap was then lifted off basally and successively towards the antecubital fossa, with smaller, outgoing vessels being treated using clips. Changed anatomical situation in the antecubital region. There is a very small radial artery as well as another artery further distally, which also enters the pedicle. The interosseous artery, brachial artery and ulnar artery were previously identified. The venous vascular system does not show a brachiocephalic vein, but a relatively large accompanying vein that opens into the brachial vein and a smaller vein above it belonging to the surface vascular system. This accompanying vein and 2 arteries are conditioned. The tourniquet is then opened. Good flow into the flap. Flap is placed on the 4 vascular structures. Treatment here using ligatures or 4.0 Prolene puncture ligatures in the area of the arteries or double treatment using clips. Flap is flushed with heparin. Flap arteries less than 1 mm or between 1 and 1.5 mm. In the area of the forearm, hemostasis and layered wound closure are performed. A full-thickness skin is typically removed from the groin area. After thinning, this is sutured into the forearm defect without tension. A Vacuseal dressing is then applied in the typical manner. Suction 75 mmHg. The forearm is immobilized in a splint using an elastic bandage. Defect covered with a radial flap: Radialis flap is inserted into the defect and successively sutured into place using 3.0 Vicryl single button sutures in the area of the pharyngeal side wall, base of the tongue and floor of the mouth. Tension-free suturing. Both sides of the neck are revised again after neck dissection with regard to the connecting vessels. The left side is selected as the connection. The radial artery and smaller accompanying artery are anastomosed with the terminal branch of the superior thyroid artery and a branch branch branching off from it using 9.0 or 10.0 ethilon sutures. Good venous return after opening the clamps. Subsequent exposure of the external jugular vein to the cranial side, where it divides. It is placed here and supplied proximally using clips. Venous outlets are conditioned, also venous outlets from the flap pedicle. Anastomosis is performed with 2.0 or 2.5 couplers. After opening the clips, venous return is also good here. Positive smear phenomenon. Flap pedicle is fixed with several sutures to prevent kinking of the vascular anastomoses. Subsequent irrigation of the wound area with Ringer's solution and careful hemostasis. Wound closure in layers on both sides of the neck with insertion of a Redon drain. The site of the Doppler check is marked. Repeated enoral check shows a vital and well-vascularized flap. Final consultation with the anesthetist. The patient is admitted to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment with Unacid started intraoperatively for 1 week. Please continue therapy with heparin perfusor 500 units per hour, also started intraoperatively, for 5 days. Feeding via the inserted PEG tube for 10 days, then if necessary build up the diet. Please monitor Doppler for 5 days according to the schedule. \ No newline at end of file diff --git a/621/InvasionFront_CD3_block5_x5_y12_patient621_0.json b/621/InvasionFront_CD3_block5_x5_y12_patient621_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d687be0f26e1513be71de2ca29d87ae7fa33261c --- /dev/null +++ b/621/InvasionFront_CD3_block5_x5_y12_patient621_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 30608.8, + "Num Detections": 26366, + "Num Negative": 25130, + "Num Positive": 1236, + "Positive %": 4.688, + "Num Positive per mm^2": 474.02 + } +} \ No newline at end of file diff --git a/621/InvasionFront_CD3_block5_x6_y12_patient621_1.json b/621/InvasionFront_CD3_block5_x6_y12_patient621_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a049d4c56a8c5462c41e2fd9783427254f819876 --- /dev/null +++ b/621/InvasionFront_CD3_block5_x6_y12_patient621_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 30558.8, + "Num Detections": 23246, + "Num Negative": 22121, + "Num Positive": 1125, + "Positive %": 4.84, + "Num Positive per mm^2": 450.66 + } +} \ No newline at end of file diff --git a/621/InvasionFront_CD8_block5_x5_y10_patient621_0.json b/621/InvasionFront_CD8_block5_x5_y10_patient621_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1accca2c32a170c27895750ddffcfac8833cb2d0 --- /dev/null +++ b/621/InvasionFront_CD8_block5_x5_y10_patient621_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 24986.8, + "Num Detections": 26672, + "Num Negative": 25919, + "Num Positive": 753, + "Positive %": 2.823, + "Num Positive per mm^2": 292.76 + } +} \ No newline at end of file diff --git a/621/InvasionFront_CD8_block5_x6_y10_patient621_1.json b/621/InvasionFront_CD8_block5_x6_y10_patient621_1.json new file mode 100644 index 0000000000000000000000000000000000000000..da1c8581620d64f15d1e5804357eacb008711045 --- /dev/null +++ b/621/InvasionFront_CD8_block5_x6_y10_patient621_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 25061.7, + "Num Detections": 28009, + "Num Negative": 27412, + "Num Positive": 597, + "Positive %": 2.131, + "Num Positive per mm^2": 234.85 + } +} \ No newline at end of file diff --git a/621/TumorCenter_CD3_block5_x5_y10_patient621_0.json b/621/TumorCenter_CD3_block5_x5_y10_patient621_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b9ad3d7195aeb2421b3cd444110527b316a024ce --- /dev/null +++ b/621/TumorCenter_CD3_block5_x5_y10_patient621_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 25311.6, + "Num Detections": 21507, + "Num Negative": 19680, + "Num Positive": 1827, + "Positive %": 8.495, + "Num Positive per mm^2": 732.87 + } +} \ No newline at end of file diff --git a/621/TumorCenter_CD3_block5_x6_y10_patient621_1.json b/621/TumorCenter_CD3_block5_x6_y10_patient621_1.json new file mode 100644 index 0000000000000000000000000000000000000000..02456a50b62a13c4e9eea73ab5370ed59ff5978e --- /dev/null +++ b/621/TumorCenter_CD3_block5_x6_y10_patient621_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 25636.4, + "Num Detections": 22655, + "Num Negative": 21349, + "Num Positive": 1306, + "Positive %": 5.765, + "Num Positive per mm^2": 503.36 + } +} \ No newline at end of file diff --git a/621/TumorCenter_CD8_block5_x5_y10_patient621_0.json b/621/TumorCenter_CD8_block5_x5_y10_patient621_0.json new file mode 100644 index 0000000000000000000000000000000000000000..405f509254a0e2cb973817a20d984b74d7c9de10 --- /dev/null +++ b/621/TumorCenter_CD8_block5_x5_y10_patient621_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 25136.7, + "Num Detections": 22357, + "Num Negative": 21795, + "Num Positive": 562, + "Positive %": 2.514, + "Num Positive per mm^2": 225.25 + } +} \ No newline at end of file diff --git a/621/TumorCenter_CD8_block5_x6_y10_patient621_1.json b/621/TumorCenter_CD8_block5_x6_y10_patient621_1.json new file mode 100644 index 0000000000000000000000000000000000000000..79432f97e4734791524f968bade9072078453b92 --- /dev/null +++ b/621/TumorCenter_CD8_block5_x6_y10_patient621_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 25186.7, + "Num Detections": 23120, + "Num Negative": 22877, + "Num Positive": 243, + "Positive %": 1.051, + "Num Positive per mm^2": 93.14 + } +} \ No newline at end of file diff --git a/621/history_text.txt b/621/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/621/icd_codes.txt b/621/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..566ff193f6ccbe27d6e87e8c2f6ce9635a981eaa --- /dev/null +++ b/621/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, nicht näher bezeichnet[C32.9 ] \ No newline at end of file diff --git a/621/ops_codes.txt b/621/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0d2e0242ff26494f1f1b952cfad7d430c45b462 --- /dev/null +++ b/621/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Inzision Zungengrund[5-250.x ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/621/patient_clinical_data.json b/621/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dcb35c1a00cc4dc95c8facf6604af0657aa8b584 --- /dev/null +++ b/621/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 50, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/621/patient_pathological_data.json b/621/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4832c8834882954d66c776ad33799935e8cd010f --- /dev/null +++ b/621/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "621", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/621/surgery_description.txt b/621/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..29b694950ae19794c13d29566387320476535660 --- /dev/null +++ b/621/surgery_description.txt @@ -0,0 +1 @@ +TORS resection, Bilateral neck dissection, PEG placement diff --git a/621/surgery_report.txt b/621/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b92c2710b477200da4af781e1fbdb2d46384204 --- /dev/null +++ b/621/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. The tracheotomy is then performed by and the PJ. For this, skin incision below the cricoid cartilage, then dissection up to the musculature, splitting of the musculature at the linea alba. Exposure of the thyroid isthmus, separation of the thyroid isthmus. Exposure of the anterior wall of the trachea and creation of a visor tracheotomy between the 2nd and 3rd tracheal cartilage. Creation of a mucocutaneous anastomosis and reintubation. Then insertion of the mouth blocker and adjustment of the tumor. Before this, the tumor was inspected again with the Kleinsasser B-tube. The tumor is located in the vallecula with transition to the lingual surface of the epiglottis and the base of the tongue on the left side. The oral retractor is then inserted and tumor resection begins. For this, 1/3 of the epiglottis must also be removed and dissection up to the base of the tongue. Hemostasis using monopolar coagulation. The preparation is thread-marked and sent to the frozen section. A resection is taken before the frozen section, as it can be seen that the median margins are barely resected. This resection is also sent to the frozen section. In the frozen section itself, all margins are tumor-free and also free of carcinoma in situ. No tumor tissue in the frozen section. Then repositioning for neck dissection on the left side. For this, skin incision in the usual manner. Exposure of the anterior margin of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Level IIa and b show a large metastasis. Then exposure of the internal jugular vein, the cervical vascular sheath and dissection of the metastasis from the internal jugular vein, including resection of the facial vein, as this infiltrates the tumor. The superior thyroid artery is also resected as the tumor infiltrates it. The accessory nerve, hypoglossus and vagus remain intact. A small medial part of the sternocleidomastoid muscle must also be removed. Then remove the remaining neck level and turn to the opposite side. Similar picture here. Skin incision in the usual manner. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, submandibular gland, digastric muscle and cervical vascular sheath. Here, too, a large metastasis is seen in level II, which is carefully dissected from the internal jugular vein. Here too, the facial vein cannot be retained, but all other structures can be retained. Clearing of the remaining neck levels and insertion of Redon drains on each side and two-layer wound closure. The patient is transferred to the intensive care unit for monitoring while awake. Before the tumor resection, a PEG was inserted using the thread pull-through method. This is successful with good diaphanoscopy. Please feed via PEG for 3 days, then build up diet and TE diet. Presentation of the patient in the tumor conference after receipt of the histology. \ No newline at end of file diff --git a/622/InvasionFront_CD3_block11_x3_y12_patient622_0.json b/622/InvasionFront_CD3_block11_x3_y12_patient622_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c06f35ed0992826f795900e8b754acd637936805 --- /dev/null +++ b/622/InvasionFront_CD3_block11_x3_y12_patient622_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 28809.7, + "Num Detections": 19786, + "Num Negative": 19479, + "Num Positive": 307, + "Positive %": 1.552, + "Num Positive per mm^2": 130.45 + } +} \ No newline at end of file diff --git a/622/InvasionFront_CD3_block11_x4_y12_patient622_1.json b/622/InvasionFront_CD3_block11_x4_y12_patient622_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5edb2ba884947755b03928c9554ecfa37be6f8af --- /dev/null +++ b/622/InvasionFront_CD3_block11_x4_y12_patient622_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 28659.8, + "Num Detections": 20504, + "Num Negative": 19571, + "Num Positive": 933, + "Positive %": 4.55, + "Num Positive per mm^2": 389.61 + } +} \ No newline at end of file diff --git a/622/InvasionFront_CD8_block11_x3_y12_patient622_0.json b/622/InvasionFront_CD8_block11_x3_y12_patient622_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a782cac005b6949ffe26d06482ddd5d6aa5a98a9 --- /dev/null +++ b/622/InvasionFront_CD8_block11_x3_y12_patient622_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13688.7, + "Centroid Y µm": 40262.3, + "Num Detections": 11361, + "Num Negative": 11276, + "Num Positive": 85, + "Positive %": 0.7482, + "Num Positive per mm^2": 58.89 + } +} \ No newline at end of file diff --git a/622/InvasionFront_CD8_block11_x4_y12_patient622_1.json b/622/InvasionFront_CD8_block11_x4_y12_patient622_1.json new file mode 100644 index 0000000000000000000000000000000000000000..96737e6f5b458a0cb2e37dffb00cbf614266afa5 --- /dev/null +++ b/622/InvasionFront_CD8_block11_x4_y12_patient622_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16282.0, + "Centroid Y µm": 40176.1, + "Num Detections": 21469, + "Num Negative": 20408, + "Num Positive": 1061, + "Positive %": 4.942, + "Num Positive per mm^2": 451.9 + } +} \ No newline at end of file diff --git a/622/TumorCenter_CD3_block11_x3_y12_patient622_0.json b/622/TumorCenter_CD3_block11_x3_y12_patient622_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5f0ec879e260f11bfe5edd1ad170508f564421ad --- /dev/null +++ b/622/TumorCenter_CD3_block11_x3_y12_patient622_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 29784.2, + "Num Detections": 12570, + "Num Negative": 11723, + "Num Positive": 847, + "Positive %": 6.738, + "Num Positive per mm^2": 523.8 + } +} \ No newline at end of file diff --git a/622/TumorCenter_CD3_block11_x4_y12_patient622_1.json b/622/TumorCenter_CD3_block11_x4_y12_patient622_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b0c4724d6651037c802be96d9166b394e82eff10 --- /dev/null +++ b/622/TumorCenter_CD3_block11_x4_y12_patient622_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15841.6, + "Centroid Y µm": 29959.1, + "Num Detections": 16016, + "Num Negative": 15616, + "Num Positive": 400, + "Positive %": 2.498, + "Num Positive per mm^2": 206.56 + } +} \ No newline at end of file diff --git a/622/TumorCenter_CD8_block11_x3_y12_patient622_0.json b/622/TumorCenter_CD8_block11_x3_y12_patient622_0.json new file mode 100644 index 0000000000000000000000000000000000000000..776da4d1958cad30dbf9155611a792df1343c71c --- /dev/null +++ b/622/TumorCenter_CD8_block11_x3_y12_patient622_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 29609.3, + "Num Detections": 14335, + "Num Negative": 13439, + "Num Positive": 896, + "Positive %": 6.25, + "Num Positive per mm^2": 507.21 + } +} \ No newline at end of file diff --git a/622/TumorCenter_CD8_block11_x4_y12_patient622_1.json b/622/TumorCenter_CD8_block11_x4_y12_patient622_1.json new file mode 100644 index 0000000000000000000000000000000000000000..16ecc961b9aec169d31f2d7afaaf853e0ed1a29b --- /dev/null +++ b/622/TumorCenter_CD8_block11_x4_y12_patient622_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 29709.3, + "Num Detections": 22160, + "Num Negative": 21659, + "Num Positive": 501, + "Positive %": 2.261, + "Num Positive per mm^2": 203.48 + } +} \ No newline at end of file diff --git a/622/history_text.txt b/622/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ba663eb9c1647728796a7788a61292085a5d73ae --- /dev/null +++ b/622/history_text.txt @@ -0,0 +1 @@ +The patient has an externally diagnosed and staged T2 oropharyngeal carcinoma on the left. \ No newline at end of file diff --git a/622/icd_codes.txt b/622/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed4aa87497852c75f601688357848e31931e81a2 --- /dev/null +++ b/622/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/622/ops_codes.txt b/622/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8133b31de4655c9c8deaeea66994fcc94f5ef79d --- /dev/null +++ b/622/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische ÖGD[1-632 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Diagnostische Laryngoskopie direkt[1-610.0 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Laterale Pharyngotomie[5-290.3 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Anlage oder Wechsel System zur Vakuumversiegelung An Haut und Unterhaut[5-916.a0 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] \ No newline at end of file diff --git a/622/patient_clinical_data.json b/622/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..45716c792a34e532dbc0b863f4185d21f8d8b091 --- /dev/null +++ b/622/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/622/patient_pathological_data.json b/622/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..19e8ee512ee20cdbc8387617fc4c450347f96a27 --- /dev/null +++ b/622/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "622", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 59, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/622/surgery_description.txt b/622/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3da7d574eaeec38d2a801254dee6c75dd40010a9 --- /dev/null +++ b/622/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Defect coverage, Free flap (Radial), Modified radical neck dissection on the right, Panendoscopy, PEG placement diff --git a/622/surgery_report.txt b/622/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9e4122a968dbd997f749dce6398ca3f6821e4e6d --- /dev/null +++ b/622/surgery_report.txt @@ -0,0 +1 @@ +First perform a panendoscopy, for this purpose first perform a rigid tracheoscopy under laryngoscopic control, this is difficult to do in very rigid conditions and restricted mouth opening, but can be performed. Here, the trachea is clear, with a whitish mucosal overlay on the right side of the glottis in the area of the anterior commissure. Otherwise unremarkable conditions. Intubation transnasally without any problems. Flexible esophagogastroscopy was then performed first. The gastroscope was inserted and the laryngoscope was checked and there were no problems with the esophagoscopy up to the stomach. Inconspicuous conditions here. Puncture of the stomach with excellent diaphanoscopy and insertion of the PEG using the usual thread pull-through method. Inspection of the esophagus on retraction, inconspicuous findings here. Now entering with the Kleinsasser tube. An exophytic tumor of the left oropharynx is seen on the left side, passing over to the soft palate to the left parauvular region. Significant lateral growth towards the mandibular branch and towards the soft tissues of the neck, the glossotonsillar groove and a circumscribed part of the base of the tongue are also affected. An extension towards the posterior pharyngeal wall and hypopharynx. Otherwise, apart from the lesion in the area of the right vocal fold described above, the findings were unremarkable. A sample is now taken from the anterior right vocal fold, which shows a polypoid mucosa in the frozen section without dysplasia or evidence of malignancy. Therefore, no further measures are taken here. Now start with the enoral resection of the tumor. For this purpose, resection of the tumor including about 2/3 of the soft palate, resection with posterior palatal arch, resection border reaching anteriorly to buccally. A clear growth towards the alveolar ridge and the soft tissues of the neck can be seen in the deep area. The tumor is now detached in the direction of the alveolar ridge. The alveolar ridge itself is not infiltrated. Push off the tumor here, laterally dissect the tumor, taking the masticatory muscles with it down to the pterygoid process. Further dissection with careful palpation of the cervical vascular sheath, removal of the tumor is very difficult with limited mouth opening in the area of the glossotonsillar junction and the base of the tongue. In this case, about 1/3 of the base of the tongue is removed. Further resection is carried out transcervically. Mucosal samples are taken covering the soft palate, buccal alveolar ridge, tongue and posterior pharyngeal wall, all of which are diagnosed as tumor-free in the frozen section. In the area of the pterygoid muscles and the lateral wall, multiple biopsies are taken in the area of the wound bed for screening purposes. All of these were later also assessed as tumor-free. Finally, the exposed alveolar ridge is ground with the diamond bur. This is followed by repositioning. First start with the neck dissection on the left side. Skin incision. Exposure of the platysma, exposure of the sternocleidomastoid muscle and the digastric and omohyoid muscles. Exposure of the submandibular gland, exposure and preservation of the facial vein, successive evacuation of the anterior neck preparation with careful protection of the superior thyroid artery, exposure of the internal jugular vein. Resection of level V with careful protection of the plexus branches. A thoracic duct cannot be visualized. No evidence of lymph flow. Evacuation of level Va and the accessorius triangle with careful protection of the nerves. Exposure of the hypoglossal nerve and the common carotid artery with its division. Exposure of the vagus nerve. Now extirpation of the submandibular gland after removal of the digastric muscle and clearing of level Ib. Now continue to expose the hypoglossal nerve as well as the internal and external jugular. After further exposure, perform the pharyngotomy. After snaring the external and internal carotid arteries and securing the hypoglossal nerve, further resection of the tumor in the area of the lateral wall of the oropharynx and base of the tongue. The lingual nerve must be removed if there is tumor infiltration. Removal of the tumor in toto. This is sent for definitive histology. The edge samples are now taken again in the caudal region, all of which are also classified as tumor-free. Finally, sufficiently wide pharyngotomy. Now ab............. and measure the required graft. At the same time, a radialis graft elevation of approx. 13 x 6 cm and neck dissection on the right, initially for radialis graft elevation. Creation of a tourniquet. After marking the graft, excision of the graft using a skin monitor. Exposure of the superficial ramus, radial nerve, a true cephalic vein is not found. Strictly subfacial preparation. Exposure of the distal lobe pedicle. Deposition after puncture and ligation and ligation with very strict subperiosteal elevation of the graft with clipping of outgoing vessels. Two strong veins develop in the antecubital region, but they do not show any confluence and have no obvious direct connection. The double-barreled venous system is left in place and the radial artery is removed. After opening the tourniquet, vital graft and good conditions, later removal of the graft after ligation and puncture. Meticulous hemostasis and careful two-layer wound closure with full-thickness skin graft from the right groin. A 13 x 6 cm full-thickness skin graft is lifted from the groin for this purpose. Strictly cutaneous preparation. Careful mobilization and undermining of the surrounding tissue. There is a discrete protrusion in the area of the outer inguinal ring, questionable inguinal hernia, but no openings. Multi-layered subcutaneous suturing and skin suturing after insertion of a 10-gauge Redon drain. In the area of the forearm, final application of a vacuum supply and application of a cramp splint. Now to the neck dissection on the right side. Skin incision for this. Exposure of the platysma, cutting of the platysma, placement of a platysma flap. Exposure of the sternocleidomastoid muscle. A true external jugular vein is not found. Exposure of the auricularis magnus nerve. Exposure of the omohyoid muscle as well as the digastric muscle and the submandibular gland. Exposure of the internal jugular vein. Evacuation of the anterior neck level while sparing the superior thyroid artery, the facial vein and the cervical sinus as well as the hypoglossal nerve. Evacuation of the accessorius triangle with careful protection of the nerve and evacuation of level V with careful protection of the plexus branches. In the area of the veno-jugulofacial angle, a 3 cm large lymph node was found, which was macroscopically suspicious, otherwise there were no macroscopically suspicious masses in the area of the neck dissection. After extensive hemostasis with dry wound conditions, insertion of a 10-gauge Redon drain and two-layer wound closure. Now perform the tracheotomy. To do this, make a horizontal skin incision and cut through the skin layers. Identification of the linea alba and the cricoid cartilage. Exposure of the thyroid isthmus, transection of the isthmus. Exposure of the anterior surface of the trachea and insertion between the 2nd and 3rd tracheal ring and performance of the mucocutaneous anastomosis, which is successful and stable. Problem-free reintubation to an 8 mm tube. At the end of the operation, reintubation onto an 8-gauge cannula with a core, which is sutured in place. The graft is now removed. Sewing in the transplant. This is extremely difficult if the mouth opening is restricted. Successive transcervical and transoral placement and final suturing of the graft combined transorally and transcervically, which is relatively difficult with a narrow mouth opening, but is successful in the end. Good fit on all sides and reconstruction of the defect, which subtotally affects the soft palate, extends anteriorly to the buccal, dorsally exceeds the middle of the posterior pharyngeal wall. Reconstruction of the glossotonsillar groove and about 1/3 of the base of the tongue and the lateral wall of the oropharynx. Now vascularization. Expose the superior thyroid artery. After positioning the stalk, perform the arterial anastomosis after cleaning the vessels with 8.0 Ethilon. This is somewhat more difficult due to the vascular relationship, but is successful. Problem-free, good flap perfusion. After opening the vascular clamps, immediately very pronounced venous return with good flap perfusion. Both venous stumps now show high reflux with no clear differences. The decision is now made to anastomose the vein preferred by . To do this, first remove the facial vein. There is complete thrombosis of the vein. Despite thrombectomy, shortening and heparin irrigation, recanalization is not successful. Another facial branch also tends to be thrombosed. Flow can only be generated if the branch is shortened back directly to the internal jugular vein, but there is no possibility of coupler anastomosis in the immediate vicinity, therefore ligation with primary in.................. Vessel diameter for the primary suture. Now also laborious vein search. Exposure of a superior thyroid vein. Here the anastomosis is successful with the size 2.5 coupler. Extremely difficult preparation conditions overall during vein preparation due to extremely thin vein walls and high vulnerability. Sufficient venous anastomosis with arterial flow, but pronounced reverse flow with multi-............. increased effect on the remaining vein. Therefore, no possibility of ligating this vein is seen here. Further laborious dissection and identification of another thyroid vein superior laborious dissection conditions. Finally, another Coupler anastomosis of size 2.5. After opening the arterial blood supply, sufficient venous anastomosis with excellent flap perfusion and vitality. Pedicle positioning and, in relatively dry wound conditions, insertion of a flap and very careful two-layer wound closure after monitor placement. Excellent flap aspects can also be seen here with enoral control. Termination of the procedure at this point. The patient received intraoperative antibiotics with Unacid, which should be continued postoperatively with Unacid 1.5 g for at least 3 days. Penetrating and hourly flap vitality check, for this purpose the superficial flap pedicle was marked with a thread, if the graft could not be completely overlooked due to the mouth opening. Please make sure to check the X-ray paps on the 9th to 10th postoperative day. Decannulation should be attempted in the medium term depending on the postoperative swallowing function. Due to the interoperative extension, certainly cT3 tumor, at least local adjuvant therapy is certainly indicated here. \ No newline at end of file diff --git a/623/InvasionFront_CD3_block16_x5_y1_patient623_0.json b/623/InvasionFront_CD3_block16_x5_y1_patient623_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9baaa215fdc4cb02377fbdaa8d51df28c0fa7b4c --- /dev/null +++ b/623/InvasionFront_CD3_block16_x5_y1_patient623_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16956.0, + "Centroid Y µm": 7182.5, + "Num Detections": 13703, + "Num Negative": 13429, + "Num Positive": 274, + "Positive %": 2.0, + "Num Positive per mm^2": 130.73 + } +} \ No newline at end of file diff --git a/623/InvasionFront_CD3_block16_x6_y1_patient623_1.json b/623/InvasionFront_CD3_block16_x6_y1_patient623_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c4dc3f0a67c3c2060da0d8d36c707873e13a6cfc --- /dev/null +++ b/623/InvasionFront_CD3_block16_x6_y1_patient623_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19397.1, + "Centroid Y µm": 7153.6, + "Num Detections": 18087, + "Num Negative": 17463, + "Num Positive": 624, + "Positive %": 3.45, + "Num Positive per mm^2": 273.42 + } +} \ No newline at end of file diff --git a/623/InvasionFront_CD8_block16_x5_y1_patient623_0.json b/623/InvasionFront_CD8_block16_x5_y1_patient623_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6eebdc208182c4e45be639dbb973e2dffa5694c3 --- /dev/null +++ b/623/InvasionFront_CD8_block16_x5_y1_patient623_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16390.0, + "Centroid Y µm": 2870.2, + "Num Detections": 16650, + "Num Negative": 16555, + "Num Positive": 95, + "Positive %": 0.5706, + "Num Positive per mm^2": 43.72 + } +} \ No newline at end of file diff --git a/623/InvasionFront_CD8_block16_x6_y1_patient623_1.json b/623/InvasionFront_CD8_block16_x6_y1_patient623_1.json new file mode 100644 index 0000000000000000000000000000000000000000..87b15400ae7a1ae9aa8527f6ded7c6eef57b1789 --- /dev/null +++ b/623/InvasionFront_CD8_block16_x6_y1_patient623_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18884.5, + "Centroid Y µm": 3047.5, + "Num Detections": 20340, + "Num Negative": 19993, + "Num Positive": 347, + "Positive %": 1.706, + "Num Positive per mm^2": 148.77 + } +} \ No newline at end of file diff --git a/623/TumorCenter_CD3_block16_x5_y1_patient623_0.json b/623/TumorCenter_CD3_block16_x5_y1_patient623_0.json new file mode 100644 index 0000000000000000000000000000000000000000..012568c54d492d4e038a4caba00b6ff3b405bc9c --- /dev/null +++ b/623/TumorCenter_CD3_block16_x5_y1_patient623_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17615.7, + "Centroid Y µm": 2923.5, + "Num Detections": 7937, + "Num Negative": 7544, + "Num Positive": 393, + "Positive %": 4.951, + "Num Positive per mm^2": 363.31 + } +} \ No newline at end of file diff --git a/623/TumorCenter_CD3_block16_x6_y1_patient623_1.json b/623/TumorCenter_CD3_block16_x6_y1_patient623_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ddbabdc59fdebe3680553fc84dd5957631f7ab6c --- /dev/null +++ b/623/TumorCenter_CD3_block16_x6_y1_patient623_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20189.3, + "Centroid Y µm": 3073.4, + "Num Detections": 17869, + "Num Negative": 16916, + "Num Positive": 953, + "Positive %": 5.333, + "Num Positive per mm^2": 432.24 + } +} \ No newline at end of file diff --git a/623/TumorCenter_CD8_block16_x5_y1_patient623_0.json b/623/TumorCenter_CD8_block16_x5_y1_patient623_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7ec5403986621c751f4bf8e959ff10fe48b24ed --- /dev/null +++ b/623/TumorCenter_CD8_block16_x5_y1_patient623_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 2648.6, + "Num Detections": 14079, + "Num Negative": 13807, + "Num Positive": 272, + "Positive %": 1.932, + "Num Positive per mm^2": 178.41 + } +} \ No newline at end of file diff --git a/623/TumorCenter_CD8_block16_x6_y1_patient623_1.json b/623/TumorCenter_CD8_block16_x6_y1_patient623_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2afe1713b5a7d02b72b85017ea489bf5d71a2dde --- /dev/null +++ b/623/TumorCenter_CD8_block16_x6_y1_patient623_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 2573.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/623/history_text.txt b/623/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b91996d5b2b3fe1683d25808b90830756ae14f81 --- /dev/null +++ b/623/history_text.txt @@ -0,0 +1 @@ +A moderately differentiated squamous cell carcinoma was confirmed histologically by biopsy in the patient with a clinically rapidly progressive, painful mass on the right edge of the tongue. In conjunction with the preoperative CT diagnosis, a cT2 cN0 cM0 G2 carcinoma of the right tongue margin was found. \ No newline at end of file diff --git a/623/icd_codes.txt b/623/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b471b784d2b9d9c09a5a3b27210fcf133740a8a5 --- /dev/null +++ b/623/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/623/ops_codes.txt b/623/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..63c07c311c7ae4d12113e83ef46a64e64aa4c792 --- /dev/null +++ b/623/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/623/patient_clinical_data.json b/623/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5c832b8e4350f5eba2100e3d2095519cc51f594b --- /dev/null +++ b/623/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 30, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/623/patient_pathological_data.json b/623/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a810ea922ad4e55cedfa0fcb951d004e629322f9 --- /dev/null +++ b/623/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "623", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 44, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/623/surgery_description.txt b/623/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6827c78c4065565e06738beaef32db0d4f7eb4f8 --- /dev/null +++ b/623/surgery_description.txt @@ -0,0 +1 @@ +Hemiglossectomy, Panendoscopy diff --git a/623/surgery_report.txt b/623/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b8e35df5e3d35359868ff12abbb8616b71f13133 --- /dev/null +++ b/623/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, a rigid tracheoscopy is performed. To do this, enter with 0° optics under laryngoscopic control. The subglottic region and the trachea are revealed. Subsequently intubation by the anesthesia colleagues. Subsequent entry with the small bore tube under dental protection after inspection of the inconspicuous oral vestibule. First inspection of the oropharynx. This is symmetrical and clear. The base of the tongue itself is clear on both sides, as are the lateral walls of the pharynx and the vallecula. Inspection of the hypopharynx, which is clear up to the tips of the piriform sinus and the entrance to the esophagus, and the endolarynx is also inconspicuous. Then perform the flexible esophagogastroscopy. To do this, enter with the gastroscope under laryngoscopic control. Easy to see through to the stomach. This is inconspicuous and clear. The oesophagus is also inconspicuous on reflection. Subsequent exploration of the oral cavity. There is an exophytic, exulcerated mass on the right edge of the tongue, extending from the anterior third to the posterior third. The exulcerated part measures approx. 2 x 1 cm, but with extensive submucosal growth. In this case, the total extension is at least 4 cm in length and at least 1.5 cm deep infiltration. The tumor is cut around with an electric knife with a safety margin of 2 cm. An extensive soft tissue mantle is also left on all sides of the tumor in the area of the musculature. Ligation of stronger vessels from the lingual artery and stronger veins, otherwise hemostasis by coagulation and removal of the tumor macroscopically clearly in sano. The specimen is completely suture-marked for urgent definitive histology. Wound irrigation and, with absolutely dry wound conditions, completion of the procedure without any indication of complications. Conclusion: Intraoperatively, macroscopically extensively resected, submucosally very aggressively growing tongue margin carcinoma. A neck dissection on both sides with defect reconstruction, most likely using an anterolateral thigh graft, should be planned as soon as possible. In the meantime, presentation at our interdisciplinary tumor conference for connection. Postoperatively, initially cautious diet and adequate pain therapy for the extensive wound area. \ No newline at end of file diff --git a/624/InvasionFront_CD3_block8_x3_y5_patient624_0.json b/624/InvasionFront_CD3_block8_x3_y5_patient624_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3c528c571664bdedfcaee606437ce134359b7cc0 --- /dev/null +++ b/624/InvasionFront_CD3_block8_x3_y5_patient624_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 22738.0, + "Num Detections": 16972, + "Num Negative": 15712, + "Num Positive": 1260, + "Positive %": 7.424, + "Num Positive per mm^2": 568.31 + } +} \ No newline at end of file diff --git a/624/InvasionFront_CD3_block8_x4_y5_patient624_1.json b/624/InvasionFront_CD3_block8_x4_y5_patient624_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4cf0b5eae68d71df4e6bbf6e542ff9ab7739ebb9 --- /dev/null +++ b/624/InvasionFront_CD3_block8_x4_y5_patient624_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 22738.0, + "Num Detections": 18026, + "Num Negative": 17806, + "Num Positive": 220, + "Positive %": 1.22, + "Num Positive per mm^2": 88.9 + } +} \ No newline at end of file diff --git a/624/InvasionFront_CD8_block8_x3_y5_patient624_0.json b/624/InvasionFront_CD8_block8_x3_y5_patient624_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c2cf0727b56df9c6ae8b7cc7d963f2a6d4f168fa --- /dev/null +++ b/624/InvasionFront_CD8_block8_x3_y5_patient624_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11768.8, + "Centroid Y µm": 12718.3, + "Num Detections": 16214, + "Num Negative": 14918, + "Num Positive": 1296, + "Positive %": 7.993, + "Num Positive per mm^2": 598.85 + } +} \ No newline at end of file diff --git a/624/InvasionFront_CD8_block8_x4_y5_patient624_1.json b/624/InvasionFront_CD8_block8_x4_y5_patient624_1.json new file mode 100644 index 0000000000000000000000000000000000000000..217b56d074f0d41466e71aad439a68ced046d9c1 --- /dev/null +++ b/624/InvasionFront_CD8_block8_x4_y5_patient624_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 12943.1, + "Num Detections": 17884, + "Num Negative": 17793, + "Num Positive": 91, + "Positive %": 0.5088, + "Num Positive per mm^2": 36.16 + } +} \ No newline at end of file diff --git a/624/TumorCenter_CD3_block8_x3_y5_patient624_0.json b/624/TumorCenter_CD3_block8_x3_y5_patient624_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee264db4dabdda58fa852ef8b112b3d1b3756240 --- /dev/null +++ b/624/TumorCenter_CD3_block8_x3_y5_patient624_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 13442.9, + "Num Detections": 17804, + "Num Negative": 17351, + "Num Positive": 453, + "Positive %": 2.544, + "Num Positive per mm^2": 210.03 + } +} \ No newline at end of file diff --git a/624/TumorCenter_CD3_block8_x4_y5_patient624_1.json b/624/TumorCenter_CD3_block8_x4_y5_patient624_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5c120d6b8c59a3503016514533bf76b39fb96525 --- /dev/null +++ b/624/TumorCenter_CD3_block8_x4_y5_patient624_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14242.5, + "Centroid Y µm": 13517.8, + "Num Detections": 8024, + "Num Negative": 7630, + "Num Positive": 394, + "Positive %": 4.91, + "Num Positive per mm^2": 427.75 + } +} \ No newline at end of file diff --git a/624/TumorCenter_CD8_block8_x3_y5_patient624_0.json b/624/TumorCenter_CD8_block8_x3_y5_patient624_0.json new file mode 100644 index 0000000000000000000000000000000000000000..51cbd6f4ae3dad3db6b5c1c0f3bb132137f034b4 --- /dev/null +++ b/624/TumorCenter_CD8_block8_x3_y5_patient624_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11543.9, + "Centroid Y µm": 13193.0, + "Num Detections": 19417, + "Num Negative": 19103, + "Num Positive": 314, + "Positive %": 1.617, + "Num Positive per mm^2": 143.14 + } +} \ No newline at end of file diff --git a/624/TumorCenter_CD8_block8_x4_y5_patient624_1.json b/624/TumorCenter_CD8_block8_x4_y5_patient624_1.json new file mode 100644 index 0000000000000000000000000000000000000000..70bcebafe3b50b2d1615a597bbc83dcb2c1424a6 --- /dev/null +++ b/624/TumorCenter_CD8_block8_x4_y5_patient624_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 12943.1, + "Num Detections": 16405, + "Num Negative": 16301, + "Num Positive": 104, + "Positive %": 0.634, + "Num Positive per mm^2": 54.12 + } +} \ No newline at end of file diff --git a/624/history_text.txt b/624/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..45a8885c57596accb1ed1a2fde87e111904de713 --- /dev/null +++ b/624/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy <2013>, a poorly differentiated squamous cell carcinoma in the area of the soft palate was histologically confirmed in the patient. In our disciplinary tumor conference, the indication for primary surgical treatment was made. \ No newline at end of file diff --git a/624/icd_codes.txt b/624/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/624/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/624/ops_codes.txt b/624/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d77d19729c988913585e594c37d17c6b45d61789 --- /dev/null +++ b/624/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Anlegen einer PEG[5-431.2 ] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Kontinuierliche Sogbehandlung mit sonstigen Systemen bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.30 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] \ No newline at end of file diff --git a/624/patient_clinical_data.json b/624/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2e5931bf78d46a194d9a1dddf749e1e9940cbc7f --- /dev/null +++ b/624/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/624/patient_pathological_data.json b/624/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2363254bfde7ab4aad3f1286f0f80cbbfb8ac312 --- /dev/null +++ b/624/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "624", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/624/surgery_description.txt b/624/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..13e7322a0c6dee943ba54c41ef89fd7bbd446a6b --- /dev/null +++ b/624/surgery_description.txt @@ -0,0 +1 @@ +Pharyngectomy, Neck dissection, Defect reconstruction, Free flap (Radial) diff --git a/624/surgery_report.txt b/624/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..79b7b26a90142f6ae96d2a1680dcc1795591e291 --- /dev/null +++ b/624/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesiology colleagues and anesthesiological preparation, the primary tumor area was inspected again. This revealed an extensive mass in the area of the soft palate with a completely tumor-infiltrated uvula, extensive infiltration of the soft palate with significant submucosal infiltration. The tumor reaches the upper tonsillar lobe on the right side, also just on the left side. Overall transverse diameter of the tumor over 4 cm, therefore T3 extension. No tumor growth beyond the tonsillar lobe to the caudal side. PEG tube inserted first. Here, insertion with the gastroscope, under laryngoscopic control, easy advancement into the stomach. If diaphanoscopy is good, the stomach is punctured without any problems and the PEG tube is inserted using the usual suture pull-through method. Subsequent repositioning of the patient with preparation for microvascular defect reconstruction. First turn to tumor resection. For this purpose, the tumor is resected with a safety margin of a good 1 cm with consecutive subtotal soft palate resection. Tonsillectomy is performed if the tumor has spread to the upper pole of the tonsil on both sides. For a better overview, the anterior palatal arch is removed on both sides. The tonsil capsules on both sides are regular, on the left side circumscribed transition to the posterior palatal arch. Generous resection here too. The back of the soft palate can now be explored. Tumor growth towards the submucosa, but no mucosal infiltration. Successive development of the tumor and resection of the tumor macroscopically in toto. Removal of the soft palate and both tonsil lobes. In the submucosal preparation, a slightly narrower approach to the tumor capsule is seen in the area of the soft palate on the right side, which is why a complete definitive resection is performed here. All margins are then covered with margin samples, all of which are assessed as tumor-free. An R0 resection can therefore be assumed here. The tumor and the resected margin are sent for definitive histology. The graft required to cover both tonsil boxes and to restore the soft palate is now measured. The graft measures a total of 13 x 6.5 cm. The neck dissection and radialis graft removal are now performed in parallel to the neck dissection. Start with the right side. Make a curved skin incision on the anterior edge of the sternocleidomastoid muscle, cut through the skin and subcutaneous tissue. Expose and cut through the platysma. Exposure of the sternocleidomastoid muscle, omohyoid muscle, exposure of the submandibular gland, exposure of the digastric muscle. Removal of the neck preparation with careful protection of the facial vein, the superior thyroid artery and the hypoglossal nerve. Free preparation of the internal jugular vein. Overall, due to the patient's anatomy and the somewhat varied course of the vessels, the preparation conditions were considerably more difficult. Exposure of the accessorius nerve, dissection of the accessorius triangle with careful protection of the nerve and dissection of level V with careful protection of the cervical plexus branches. Level Ib is then evacuated with extirpation of the submandibular gland. This is followed by resection of the digastric muscle and a pharyngotomy measuring approx. 2 ˝ QF to position the pedicle. Overall, several nodules in the neck area, conspicuous in size and number, without infiltration of neighboring structures. In principle, the same procedure was used on the left side. Cut through skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Ligation of very strong superficial veins with drainage into the anterior jugular vein and external jugular vein. Clearing of the anterior neck preparation with preservation of a deep facial vein branch, a superficial facial branch is removed. Exposure and preservation of the superior thyroid artery and hypoglossal nerve. Dissection of the internal jugular vein. Numerous lymph nodes can be seen in the area of the very deep vein angle. Macroscopically highly visible nodus measuring approx. 3.5 cm. Careful dissection of the accessorius nerve, but this can be preserved. Clearing of the accessorius triangle with careful preservation of the nerve and clearing of level V with careful preservation of the cervical plexus branches. Subsequently skeletonize the submandibular gland and evacuate level Ib while carefully protecting the oral branch. Careful wound inspection and palpation, followed by wound irrigation with H202 and Ringer's solution. Insertion of a 10-gauge Redon drain and careful two-layer wound closure. At the same time, the radialis graft was harvested from the left forearm. After marking the graft, the tourniquet was applied. Cutting around the graft. Radial exploration of the cephalic vein. Perform the Haydn maneuver to identify the superficial ramus, radial nerve. Locate the distal vascular pedicle. Dissection after ligation. Ulnar dissection with exposure and visualization of the flexo carpi ulnaris. Complete detachment of the graft by strict subfascial dissection, proximal dissection of the pedicle including the drainage area of the cephalic vein. Careful clipping of outgoing veins in the antecubital fossa. Exposure of the extremely strong bridge of the radial veins into the cubital veins, including the cephalic vein. Positioning of the venous system to the side and exposure of the radial artery with securing of the outlet of the ulnar artery, reopening of the tourniquet. Careful, meticulous hemostasis with a regular graft. After removal of the graft, the wound is carefully closed in two layers in the forearm area and the full-thickness skin graft harvested from the groin is inserted. The vacuum sealing pump is then applied and the Cramer splint is placed in the functional position. For full-thickness skin harvesting from the right groin, incision of a full-thickness skin graft measuring approx. 14 x 6 cm, strictly cutaneous elevation. Subcutaneous mobilization, insertion of a 10-gauge Redon drain after careful wound inspection and hemostasis. Subsequent strong two-layer wound closure. The radialis graft is now inserted. Successive insertion with significantly more difficult insertion conditions due to the swelling that has now occurred and the rather strong radialis graft, successive insertion. Finally, good reconstruction of the soft palate with the graft still in place. Careful cervical stem displacement. Cervical preparation of the right side of the facial vein and the superior thyroid artery. The facial artery is also prepared. This is followed by anastomosis with the superior thyroid artery due to a jump in the caliber of the suture. After initially regular flow, there is now a lack of venous flow. Cessation of pedicle pulsation, therefore reopening of the artery in case of occlusion. Due to the rather unfavorable caliber conditions, preparation of the facial artery and renewed arterial anastomosis with 8.0 Ethilon. This now works well. Immediate regular venous return and excellent graft perfusion so that venous anastomosis with the coupler system is performed after preparation of the flap vein and the facial vein. After measuring a size 3.5 coupler, anastomosis is performed without any problems. Subsequent regular graft perfusion. Careful cervical wound inspection, wound irrigation and subsequent insertion of a guided 10 Redon drainage and careful two-layer wound closure. Due to the significant swelling that has now set in, a plastic tracheostomy is then performed. A horizontal incision is made at the level of the cricoid cartilage. Cut through the skin and subcutaneous tissue. Ligation of superficially pronounced veins. Dissection of the infrahyoid muscles. Exposure of the cricoid cartilage. Exposure of the very deep trachea. Exposure and transection of the thyroid isthmus. Exposure of the anterior surface of the trachea. This shows a clear ........ or ossification of the trachea. Entry between the 2nd and 3rd tracheal ring. Somewhat laborious creation of a broad-based Björk flap with clear ossifications in the area of the tracheal clasps. Subsequent insertion of the tracheostoma with generally difficult insertion conditions due to the cartilage conditions. Subsequently, problem-free reintubation to a size 9 low cuff cannula and, after final enoral inspection with a vital graft, termination of the procedure at this point. Conclusion: Intraoperative R0 resected cT3 cN2c soft palate carcinoma. Reconstruction using a radialis graft. Due to the initial graft swelling and the more difficult adaptation conditions, the patient should not be given food until the 10th postoperative day. With proper graft healing and swallowing function, timely closure of the tracheostoma should be possible. \ No newline at end of file diff --git a/625/InvasionFront_CD3_block22_x5_y12_patient625_0.json b/625/InvasionFront_CD3_block22_x5_y12_patient625_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cbe9c8e52f9dba03b6687ec080af957e2c187401 --- /dev/null +++ b/625/InvasionFront_CD3_block22_x5_y12_patient625_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16816.1, + "Centroid Y µm": 41628.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/625/InvasionFront_CD3_block22_x6_y12_patient625_1.json b/625/InvasionFront_CD3_block22_x6_y12_patient625_1.json new file mode 100644 index 0000000000000000000000000000000000000000..291cb98b03ba2c3b594665ae1502ca16d8e0d0c3 --- /dev/null +++ b/625/InvasionFront_CD3_block22_x6_y12_patient625_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 41677.9, + "Num Detections": 16745, + "Num Negative": 15010, + "Num Positive": 1735, + "Positive %": 10.36, + "Num Positive per mm^2": 930.46 + } +} \ No newline at end of file diff --git a/625/InvasionFront_CD8_block22_x5_y12_patient625_0.json b/625/InvasionFront_CD8_block22_x5_y12_patient625_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d1b21ee255b4db0a9d8b0fea85d8754116dcc31 --- /dev/null +++ b/625/InvasionFront_CD8_block22_x5_y12_patient625_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 29284.5, + "Num Detections": 9857, + "Num Negative": 9350, + "Num Positive": 507, + "Positive %": 5.144, + "Num Positive per mm^2": 393.13 + } +} \ No newline at end of file diff --git a/625/InvasionFront_CD8_block22_x6_y12_patient625_1.json b/625/InvasionFront_CD8_block22_x6_y12_patient625_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd3dc50ab9bc68217a60c93dfb5527897f400f0a --- /dev/null +++ b/625/InvasionFront_CD8_block22_x6_y12_patient625_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21838.4, + "Centroid Y µm": 29434.4, + "Num Detections": 15374, + "Num Negative": 12862, + "Num Positive": 2512, + "Positive %": 16.34, + "Num Positive per mm^2": 1358.6 + } +} \ No newline at end of file diff --git a/625/TumorCenter_CD3_block22_x5_y12_patient625_0.json b/625/TumorCenter_CD3_block22_x5_y12_patient625_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69fffda895187ed980b4b2002312167be6fbf9b9 --- /dev/null +++ b/625/TumorCenter_CD3_block22_x5_y12_patient625_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 30309.0, + "Num Detections": 15518, + "Num Negative": 14653, + "Num Positive": 865, + "Positive %": 5.574, + "Num Positive per mm^2": 507.01 + } +} \ No newline at end of file diff --git a/625/TumorCenter_CD3_block22_x6_y12_patient625_1.json b/625/TumorCenter_CD3_block22_x6_y12_patient625_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ca30351141d3d86ba6e4b6be6ab4592c95061203 --- /dev/null +++ b/625/TumorCenter_CD3_block22_x6_y12_patient625_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18315.3, + "Centroid Y µm": 30209.0, + "Num Detections": 14589, + "Num Negative": 13758, + "Num Positive": 831, + "Positive %": 5.696, + "Num Positive per mm^2": 533.36 + } +} \ No newline at end of file diff --git a/625/TumorCenter_CD8_block22_x5_y12_patient625_0.json b/625/TumorCenter_CD8_block22_x5_y12_patient625_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba21758d2739e6d549a0fe6201b35df17c7d4be7 --- /dev/null +++ b/625/TumorCenter_CD8_block22_x5_y12_patient625_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18240.3, + "Centroid Y µm": 40428.6, + "Num Detections": 12304, + "Num Negative": 11274, + "Num Positive": 1030, + "Positive %": 8.371, + "Num Positive per mm^2": 582.43 + } +} \ No newline at end of file diff --git a/625/TumorCenter_CD8_block22_x6_y12_patient625_1.json b/625/TumorCenter_CD8_block22_x6_y12_patient625_1.json new file mode 100644 index 0000000000000000000000000000000000000000..619ce63678cea2f946e76667ba249eef4dca7385 --- /dev/null +++ b/625/TumorCenter_CD8_block22_x6_y12_patient625_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20589.1, + "Centroid Y µm": 40453.6, + "Num Detections": 12639, + "Num Negative": 11499, + "Num Positive": 1140, + "Positive %": 9.02, + "Num Positive per mm^2": 710.85 + } +} \ No newline at end of file diff --git a/625/history_text.txt b/625/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..cee67c0ec68abe4c6234d533ad94cbc1840e98e7 --- /dev/null +++ b/625/history_text.txt @@ -0,0 +1 @@ +The patient presented in domo for the first time <2013> with progressive stridor with a known progressive laryngeal mass. During a panendoscopy with emergency tracheotomy, a glottic laryngeal carcinoma of at least cT3 was histologically confirmed. Our interdisciplinary tumor conference decided on primary surgical treatment. Secondary findings revealed an open tuberculosis, which was primarily treated with medication. The patient now presented after completion of TB treatment with clear tumor growth per continuitatem through the existing tracheostoma. Immediately preoperatively, an exophytic tumor measuring approx. 5 x 6 cm was found around the tracheostoma with satellite-like tumor foci DD skin metastases. CT confirmed the extension with glottic carcinoma with complete consumption of the larynx and breakthrough through the tracheostoma to cutaneous and infiltration of the trachea with a new paratracheal mass on the left. \ No newline at end of file diff --git a/625/icd_codes.txt b/625/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/625/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/625/ops_codes.txt b/625/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4696ac76caec5a1dc2531bb9d8ded45efd3c8e87 --- /dev/null +++ b/625/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Schilddrüsenteilresektion[5-062.8 B] Resektion an der Trachea mit Anlegen eines Tracheostomas[5-314.12 ] Einfache Laryngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.04 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/625/patient_clinical_data.json b/625/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8732527ca60070f1cb988b4832ba18c6b3a70c38 --- /dev/null +++ b/625/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 120, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/625/patient_pathological_data.json b/625/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7c2c7a0036bd41421fde7da78dec05efebdd4c29 --- /dev/null +++ b/625/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "625", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 14.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/625/surgery_description.txt b/625/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d743d92871359101c0491ee9e547a262e8b466f --- /dev/null +++ b/625/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Defect reconstruction, Free flap (ALT), Tracheostomy reconstruction diff --git a/625/surgery_report.txt b/625/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..593b9e2e75416418ab74c78307f215706bd340dc --- /dev/null +++ b/625/surgery_report.txt @@ -0,0 +1 @@ +First of all, external inspection of the previously described, exulcerated tumor. Entry with the small bore tube under dental protection. Inconspicuous oral cavity and oropharynx. The base of the tongue and vallecula are also clear, as is the epiglottis. An exophytic, endolaryngeal tumor growth with complete displacement of the glottis or glottic entrance is now visible. However, the tumor does not exceed the aryepiglottic folds on both sides or the arytenoid region. Completely free hypopharynx, which can be visualized as far as the piriform sinus tips and the esophageal entrance. Insertion of a nasogastric feeding tube under visualization. The patient is then positioned and xylocaine with adrenaline is injected. The exophytic tumor growth is completely incised with a safety margin. Widening of the skin incision to lift an apron flap. Subplatysmal flap elevation is then performed first. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. All structures not infiltrated. Exposure of both sides of the internal jugular vein and facial vein. Exposure of the cervical vascular sheath. Exposure of the superior thyroid artery on both sides and the thyroid gland. Caudal visualization of the trachea. This is free of tumors caudally. If the tumor is externally on the right side, it can now be seen in depth on the left side. Paratracheal thyroid infiltration on the left. Paratracheal therefore subtotal thyroid resection, the vagus nerve is caudally caked into the conglomerate and is resected caudally. Right-sided circumscribed partial thyroidectomy, here with preservation of the superior thyroid artery on the left side. Ligation of the artery. Several lymph nodes conspicuous in number and size on both sides, but without definite malignancy criteria or perinodal growth. Clearing of level II to IV on both sides. Now visualization of the hyoid. Skeletonization of the larynx. Complete caudal exposure of the trachea. Entry into the trachea with resection of 2 tracheal clips, here macroscopically tumor-free externally. Complete mobilization of the larynx and the caudal tumour conglomerate. Entry pharyngeally at the level of the vallecula. Mucosa-sparing release of the epiglottis. Resection along the aryepiglottic fold with a safety margin of approx. 1.5 cm, also in the postcricoid region. Release the laryngeal skeleton while carefully protecting the esophagus. Performing the myotomy in the area of the upper esophageal sphincter and caudally in the area of the trachea to remove the larynx and the tumor in toto. On the left paratracheal side, there was a suspicious mass in the form of a lividly discolored, suspicious lymph node, corresponding to the CT diagnosis. Inspection of the specimen showed both the laryngeal tumor portion and the subglottic portion resected in sano on all sides with a safety margin of a good 1 cm. Somewhat unclear tissue changes or conspicuous changes in the caudal musculature. For this reason, a complete soft tissue margin sample was taken here, as well as imaging with margin samples of the entire tumor in the area of the mucosa and in the area of the tracheal abscess margin. Complete imaging of the skin resectate beforehand. All samples are diagnosed as completely tumor-free, meaning that an R0 resection has been achieved. The size of the defect is now measured, a skin defect measuring 11 x 7 cm in total. An anterolateral thigh graft is then harvested from the right. After marking the landmarks and doppler sonographic identification of the skin perforator and a strong secondary perforator, mark a spindle-shaped graft measuring approx. 12.5 x 7.5 cm. Medial incision. Exposure and securing of the rectus femoris muscle. Strictly subfascial preparation. Exposure of the perforators and the vascular pedicle. Performing the extension incision. Dissection of the vascular pedicle and release in the area of the intermedius muscle. A superficial musculocutaneous perforator course can be seen. Caudal removal of the vascular pedicle and elevation of the graft, taking the fascia lata with it. Inclusion of a narrow muscle cuff in the area of the perforators. Conditioning of the vessels and, if the graft is vital, removal of the graft. Careful wound inspection and, if the wound is dry, insertion of a 10 Redon drain and careful, two-layer wound closure. The graft is now inserted, initially tracheally. If the trachea is clearly set off caudally, there will be slightly increased tension even after mobilization, especially in the pectoral skin area. Here, mobilization of the skin as far as possible and insertion of the trachea anteriorly as described above under increased tension conditions. Later, successive insertion of the tracheostoma primarily through the graft. Microvascular anastomosis is then performed on the right side. Conditioning of the lingual artery. Perform the arterial anastomosis with 8-0 Ethilon; this is successful and sufficient. Immediate regular venous return via primarily one flap vein, therefore occlusion of the 2nd vein. Conditioning of the facial vein. Perform the venous anastomosis with the coupler system size 3.0, followed by regular pedicle perfusion, positive smear test and regular flap perfusion. Then complete incorporation of the graft after checking all wound regions. In the case of dry wound conditions, insertion of a 10 Redon drain here. Subsequently, careful, two-layer wound closure with fitting of the graft. Finally, with a vital graft and fully incorporated tracheostoma, reintubation to a size 10 low cuff cannula and completion of the procedure without any indication of complications. Conclusion: Intraoperative R0-resected, extensive cT4a cN+ laryngeal carcinoma with extensive peristomal spread. Postoperatively, please continue the intraoperatively started intravenous antibiotics with Unacid 3 g for 24 hours. If the wound is healing properly, perform an X-ray gruel on the 10th postoperative day. Special wound observation in the area of the tracheostoma in case of difficult tissue conditions. If the wound is healing properly, rapid administration of the urgently required adjuvant therapy. \ No newline at end of file diff --git a/626/InvasionFront_CD3_block16_x5_y2_patient626_0.json b/626/InvasionFront_CD3_block16_x5_y2_patient626_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7efcabf7dd54330a7d24b242dbd4e824e929459b --- /dev/null +++ b/626/InvasionFront_CD3_block16_x5_y2_patient626_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16802.1, + "Centroid Y µm": 9531.8, + "Num Detections": 15008, + "Num Negative": 14482, + "Num Positive": 526, + "Positive %": 3.505, + "Num Positive per mm^2": 244.75 + } +} \ No newline at end of file diff --git a/626/InvasionFront_CD3_block16_x6_y2_patient626_1.json b/626/InvasionFront_CD3_block16_x6_y2_patient626_1.json new file mode 100644 index 0000000000000000000000000000000000000000..71e067765adef7034d537f3e09439b77a23a8813 --- /dev/null +++ b/626/InvasionFront_CD3_block16_x6_y2_patient626_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19397.1, + "Centroid Y µm": 9621.2, + "Num Detections": 17559, + "Num Negative": 17374, + "Num Positive": 185, + "Positive %": 1.054, + "Num Positive per mm^2": 85.04 + } +} \ No newline at end of file diff --git a/626/InvasionFront_CD8_block16_x5_y2_patient626_0.json b/626/InvasionFront_CD8_block16_x5_y2_patient626_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d9d4796d5d15c14df3fcca874d46a64acbf68a1a --- /dev/null +++ b/626/InvasionFront_CD8_block16_x5_y2_patient626_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16233.3, + "Centroid Y µm": 5229.3, + "Num Detections": 17863, + "Num Negative": 17757, + "Num Positive": 106, + "Positive %": 0.5934, + "Num Positive per mm^2": 47.54 + } +} \ No newline at end of file diff --git a/626/InvasionFront_CD8_block16_x6_y2_patient626_1.json b/626/InvasionFront_CD8_block16_x6_y2_patient626_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f5fd09313ec823911c0d77e48fa1e5e93b94ef68 --- /dev/null +++ b/626/InvasionFront_CD8_block16_x6_y2_patient626_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18817.3, + "Centroid Y µm": 5518.6, + "Num Detections": 17366, + "Num Negative": 17335, + "Num Positive": 31, + "Positive %": 0.1785, + "Num Positive per mm^2": 13.7 + } +} \ No newline at end of file diff --git a/626/TumorCenter_CD3_block16_x5_y2_patient626_0.json b/626/TumorCenter_CD3_block16_x5_y2_patient626_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a072ceee349e37657f72d28329bf983b10a7dff3 --- /dev/null +++ b/626/TumorCenter_CD3_block16_x5_y2_patient626_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17440.8, + "Centroid Y µm": 5472.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/626/TumorCenter_CD3_block16_x6_y2_patient626_1.json b/626/TumorCenter_CD3_block16_x6_y2_patient626_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ce30ba4f0bf55413e99893d2910e3070bc9a7f4 --- /dev/null +++ b/626/TumorCenter_CD3_block16_x6_y2_patient626_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 5597.0, + "Num Detections": 13591, + "Num Negative": 13375, + "Num Positive": 216, + "Positive %": 1.589, + "Num Positive per mm^2": 98.73 + } +} \ No newline at end of file diff --git a/626/TumorCenter_CD8_block16_x5_y2_patient626_0.json b/626/TumorCenter_CD8_block16_x5_y2_patient626_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c6ab00775bb55fdeff00c6f5d1d274432d5d2ca3 --- /dev/null +++ b/626/TumorCenter_CD8_block16_x5_y2_patient626_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 5247.2, + "Num Detections": 11636, + "Num Negative": 11614, + "Num Positive": 22, + "Positive %": 0.1891, + "Num Positive per mm^2": 13.18 + } +} \ No newline at end of file diff --git a/626/TumorCenter_CD8_block16_x6_y2_patient626_1.json b/626/TumorCenter_CD8_block16_x6_y2_patient626_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8afeeac2506f7a0640fd59b072cfe56299a246db --- /dev/null +++ b/626/TumorCenter_CD8_block16_x6_y2_patient626_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 5172.3, + "Num Detections": 14799, + "Num Negative": 14782, + "Num Positive": 17, + "Positive %": 0.1149, + "Num Positive per mm^2": 8.048 + } +} \ No newline at end of file diff --git a/626/history_text.txt b/626/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6365b188216ee6a8b2241b82650c2ad453566cd2 --- /dev/null +++ b/626/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT3 cN2b G2 tongue margin carcinoma on the right was histologically confirmed during a panendoscopy on <2013>. In our interdisciplinary tumor conference, the primary surgical procedure was indicated. Sonographically, there is a largely constant cN2b neck status on the right. \ No newline at end of file diff --git a/626/icd_codes.txt b/626/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..78784449097c45eca618676bb603bb5427826c74 --- /dev/null +++ b/626/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] Plattenepithelkarzinom Zungenrand[C02.1 ] \ No newline at end of file diff --git a/626/ops_codes.txt b/626/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..43117bbc1d97d49f6f71bce857faee3640a6ccc9 --- /dev/null +++ b/626/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Mundbodenteilresektion[5-273.6 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Transplantation eines myokutanen Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-858.78 R] Laterale Pharyngotomie[5-290.3 ] \ No newline at end of file diff --git a/626/patient_clinical_data.json b/626/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..da98f6e8f0b6bff7c53854d13628454f453afe73 --- /dev/null +++ b/626/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/626/patient_pathological_data.json b/626/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..85ccd56a90a22e279d1dca0450d20efd7936713b --- /dev/null +++ b/626/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "626", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 28, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/626/surgery_description.txt b/626/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c59d751bac4c2e4c13931381b6b0a45f8e5ad6f --- /dev/null +++ b/626/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Tracheostomy diff --git a/626/surgery_report.txt b/626/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad9cad9e16c1c3374615fabc5210d8326660712d --- /dev/null +++ b/626/surgery_report.txt @@ -0,0 +1 @@ +Initial inspection of the primary tumor region. There is an exulcerated mass on the right edge of the tongue, only the tip of the tongue is left out. Extensive submucosal growth. The tumor clearly reaches the midline approximately in the area of the middle of the tongue and also crosses it submucosally; tumor growth decreases again towards the base of the tongue. The basal base of the tongue towards the vallecula is tumor-free again. In addition, exophytic tumor growth over the glossotonsillar groove and circumscribing the posterior floor of the mouth onto the anterior palatal arch. In the anterior palatal arch, tumor cones at the mucosal level up to above the uvula cavity. The tumor can be palpated and moved in a cervical direction, therefore a primarily transoral approach was initially performed. Cut around the tumor and dissect using the electric needle and dissection technique, maintaining a safety distance of at least 1-1.5 cm. The lingual nerve can be kept straight, the lingual artery is ligated and removed. Macroscopic clear in sano removal with a clearly tumor-free covering soft tissue mantle on all sides, especially submucosally. This is followed by the removal of completely covering marginal samples at the mucosal level and the removal of largely covering marginal samples in the area of the tongue body. An in sano resection for the invasive carcinoma can be seen on all sides. In the frozen section diagnosis, only in the area of the glosstonsillar furrow, where the distance is actually macroscopically wide, is there still a circumscribed Cis. For this reason, a resection was performed and a new covering margin sample was taken, which again showed no tumor or dysplasia, so that a clear R0 situation can be assumed. Overall, this results in an extensive defect of the tongue with approx. 2/3 resection, especially in the area of the middle of the tongue body. The soft palate portion was resected basally together with a tonsillectomy. As a result, the tonsil lobe and the posterior floor of the mouth were circumscribed. Measurement of the defect for later defect reconstruction, in the meantime bilateral tracheotomy is performed. Start with the right side. Submandibular skin incision, cutting through skin and subcutaneous tissue, cutting through the platysma, exposing the sternocleidomastoid muscle, exposing the omohyoid muscle, exposing the submandibular gland and the digastric muscle. Removal of the anterior neck preparation and preservation of the superior thyroid artery of the hypoglossal nerve of the cervical anus. A narrow facial vein branch must be removed later during tunnel creation. Free preparation of the internal jugular vein, overall in level II and III some nodules of conspicuous size and configuration, but without surrounding infiltration. Clearing of the accessorius triangle and level Va with careful protection of the accessorius nerve and the cervical plexus branches. Finally, if the wound is dry, turn to the opposite side. Exactly the same procedure here, no macroscopically conspicuous nodes. The facial vein is preserved here, as is the external jugular vein on both sides. On the left side after evacuation of level IIa to Va. Wound irrigation with H202 and Ringer's solution. Insertion of a 10-gauge Redon drain and careful two-layer wound closure. Submandibulectomy is then performed on the right side and the tunnel is passed enorally. Widening of the tunnel, resection of the digastric muscle. Evacuation of level Ib with removal of further, macroscopically non-suspicious nodes. Ligation of the facial artery and after creation of a sufficient tunnel, later passage of the lifted graft to lift the antero-lateral thigh graft from the right. After marking the landmarks and doppler sonographic identification of the main perforator and two secondary perforators, the graft specially configured for the tongue edge/bottom of the mouth and tonsil region is marked. The graft measures a total of 16 x 7 cm. Medial incision due to the reconstruction of the entire length of the tongue up to almost the tip of the tongue. Identification of the rectus femoris muscle strictly subfacially. Dissection, identification of the vascular pedicle. Making the auxiliary incision. The supply of the graft through the ramus descendens is shown with a clearly visible fasciocutaneous course of the main perforator. Subfacial release. Incision of the graft involving the fascia lata. A narrow muscle cuff is left in the area of the outgoing main perforator. Isolation on the vascular pedicle. A strong accompanying vein with an additional narrower accompanying vein can be elevated so that the graft can then be placed under vital conditions. Careful wound inspection and hemostasis in the lifting area. Subsequent insertion of a 10-gauge Redon drain and careful multi-layer wound closure. The graft is then inserted under moderate tension. Due to the size of the defect and the graft, the conditions for insertion were considerably more difficult. Under laborious conditions, incorporation of the graft with an overall very good fit and complete coverage of the defect. After combined transoral and transcervical insertion, intact conditions on all sides. Pedicle positioning and conditioning of the pedicle vessels as well as the superior thyroid artery and the middle thyroid vein. Performing the arterial anastomoses with 8-0 Ethilon, revealing clearly vulnerable vessel walls with a large amount of vascular plaque, particularly in the area of the graft vessels. Clearly difficult adaptation conditions here. After initial anastomosis, there is no regular circulation. After opening the artery, ............... resection is seen. Careful excision of the anastomosis and repeat procedure. This is now sufficient and regular. Immediate regular venous return. Conditioning of the stronger flap vein and closure of the smaller one with sufficient venous outflow. Conditioning of the V. thyroidea media and insertion of the venous anastomoses with the coupler system using a size 3.0 coupler. Subsequently, with a positive smear phenomenon, regular pedicle position and regular flap vitality. Wound irrigation. Insertion of a size 10 Redon drain and careful two-layer wound closure. Finally, a plastic tracheotomy is performed. This involves a horizontal skin incision below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure and transection of the infrahyoid musculature. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea, transection of the slender thyroid isthmus. Due to the height of the larynx, insertion between the 1st and 2nd tracheal ring. Creation of a visor tracheotomy and insertion of the tracheostoma. Subsequent reintubation without difficulty to a size 8 low cuff cannula, which is suture-fixed. The procedure was then completed with a vital graft and no indication of complications. The patient received intraoperative intravenous antibiotics with Unacid, which should be continued for 24 hours postoperatively. Conclusion: Intraoperative R0 resected extensive cT3 cN2b tongue margin carcinoma on the right with extensive ALT reconstruction. Please abstain from food for at least 7 days, then the first swallowing diagnosis can be started if the flap is viable. Overall, a prolonged recovery of swallowing function can be expected due to the extensive defect. Presentation in our interdisciplinary tumor conference to determine the adjuvant therapy that is certainly indicated. \ No newline at end of file diff --git a/627/InvasionFront_CD3_block7_x1_y10_patient627_0.json b/627/InvasionFront_CD3_block7_x1_y10_patient627_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cc33bba2a8dc4c31e0ab8752a01fed08d4a7354a --- /dev/null +++ b/627/InvasionFront_CD3_block7_x1_y10_patient627_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4172.8, + "Centroid Y µm": 24599.5, + "Num Detections": 19363, + "Num Negative": 17328, + "Num Positive": 2035, + "Positive %": 10.51, + "Num Positive per mm^2": 921.99 + } +} \ No newline at end of file diff --git a/627/InvasionFront_CD3_block7_x2_y10_patient627_1.json b/627/InvasionFront_CD3_block7_x2_y10_patient627_1.json new file mode 100644 index 0000000000000000000000000000000000000000..daf977aea8160e9ad631d1d22c5cdc29197ae2b4 --- /dev/null +++ b/627/InvasionFront_CD3_block7_x2_y10_patient627_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6796.4, + "Centroid Y µm": 24462.0, + "Num Detections": 19838, + "Num Negative": 17434, + "Num Positive": 2404, + "Positive %": 12.12, + "Num Positive per mm^2": 1139.6 + } +} \ No newline at end of file diff --git a/627/InvasionFront_CD8_block7_x1_y10_patient627_0.json b/627/InvasionFront_CD8_block7_x1_y10_patient627_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c8cd84db065ee1e22d95bbc05e5016fbee3da1f6 --- /dev/null +++ b/627/InvasionFront_CD8_block7_x1_y10_patient627_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 24512.0, + "Num Detections": 21509, + "Num Negative": 20019, + "Num Positive": 1490, + "Positive %": 6.927, + "Num Positive per mm^2": 729.64 + } +} \ No newline at end of file diff --git a/627/InvasionFront_CD8_block7_x2_y10_patient627_1.json b/627/InvasionFront_CD8_block7_x2_y10_patient627_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3d179338be62d0660fdf36bebd26852b488c4c26 --- /dev/null +++ b/627/InvasionFront_CD8_block7_x2_y10_patient627_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 24836.8, + "Num Detections": 19840, + "Num Negative": 18972, + "Num Positive": 868, + "Positive %": 4.375, + "Num Positive per mm^2": 417.96 + } +} \ No newline at end of file diff --git a/627/TumorCenter_CD3_block7_x1_y10_patient627_0.json b/627/TumorCenter_CD3_block7_x1_y10_patient627_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a83ec7ebf4c39ec668ed53cd2515823127096c71 --- /dev/null +++ b/627/TumorCenter_CD3_block7_x1_y10_patient627_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 25311.6, + "Num Detections": 25746, + "Num Negative": 18497, + "Num Positive": 7249, + "Positive %": 28.16, + "Num Positive per mm^2": 2604.9 + } +} \ No newline at end of file diff --git a/627/TumorCenter_CD3_block7_x2_y10_patient627_1.json b/627/TumorCenter_CD3_block7_x2_y10_patient627_1.json new file mode 100644 index 0000000000000000000000000000000000000000..af75ec52566e44caa10a6c8d171260f13a185ca1 --- /dev/null +++ b/627/TumorCenter_CD3_block7_x2_y10_patient627_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6046.8, + "Centroid Y µm": 25386.6, + "Num Detections": 24611, + "Num Negative": 21142, + "Num Positive": 3469, + "Positive %": 14.1, + "Num Positive per mm^2": 1351.2 + } +} \ No newline at end of file diff --git a/627/TumorCenter_CD8_block7_x1_y10_patient627_0.json b/627/TumorCenter_CD8_block7_x1_y10_patient627_0.json new file mode 100644 index 0000000000000000000000000000000000000000..76f8a92559e5e89b14ad5f55827a3a0e98c314c5 --- /dev/null +++ b/627/TumorCenter_CD8_block7_x1_y10_patient627_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3248.3, + "Centroid Y µm": 25136.7, + "Num Detections": 31816, + "Num Negative": 30719, + "Num Positive": 1097, + "Positive %": 3.448, + "Num Positive per mm^2": 405.65 + } +} \ No newline at end of file diff --git a/627/TumorCenter_CD8_block7_x2_y10_patient627_1.json b/627/TumorCenter_CD8_block7_x2_y10_patient627_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e4fe9c1522cc5d076e7eccd88c14af24787d690e --- /dev/null +++ b/627/TumorCenter_CD8_block7_x2_y10_patient627_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 25161.7, + "Num Detections": 28718, + "Num Negative": 28244, + "Num Positive": 474, + "Positive %": 1.651, + "Num Positive per mm^2": 184.31 + } +} \ No newline at end of file diff --git a/627/history_text.txt b/627/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..416f9c483547ed7a6835496c06c0be71dc3e5ee6 --- /dev/null +++ b/627/history_text.txt @@ -0,0 +1 @@ +The patient has a case of non-touch panendo with suspected cup syndrome with histologically confirmed cervical lymph node metastasis on the left by coarse needle biopsy. The PET-CT shows a flat asymmetry of the enhancement in the area of the tonsil on the left more than on the right. In the ENT mirror findings, the left tonsil can be palpated discretely harder than the right, otherwise no suspicious mass. Based on the medical history and clinical findings, indication for the above-mentioned procedure. \ No newline at end of file diff --git a/627/icd_codes.txt b/627/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0eb919f54e1ea594f16fd83c9f763a12f67c6fb --- /dev/null +++ b/627/icd_codes.txt @@ -0,0 +1 @@ +Tonsillenkarzinom[C09.9 L] \ No newline at end of file diff --git a/627/ops_codes.txt b/627/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a42bc428b6e4093ef7f72c289acedf0beb2361b0 --- /dev/null +++ b/627/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Tonsillektomie onA[5-281.y ] Selektive Neck dissection in 5 Regionen[5-403.04 L] \ No newline at end of file diff --git a/627/patient_clinical_data.json b/627/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ffbc104274da6b463978a9a71fdbfc488776800f --- /dev/null +++ b/627/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/627/patient_pathological_data.json b/627/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6eb8815ba02d9d290d99b149e2d5449c0d049b88 --- /dev/null +++ b/627/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "627", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/627/surgery_description.txt b/627/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50312bf02ac9be42bdb574ea1e368d8a571c1efe --- /dev/null +++ b/627/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection diff --git a/627/surgery_report.txt b/627/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b25539292c842db5ab796e8e81b876942e414367 --- /dev/null +++ b/627/surgery_report.txt @@ -0,0 +1 @@ +First, transfer the patient to the operating theater. Then active patient identification and team time out. Consultation with the anesthesia department. Then induction of anesthesia and intubation by the anesthesia colleagues. Then head positioning by the surgeon and insertion of the Mc Ivor mouth spatula, taking into account the teeth, lips and tongue. Repeated inspection and palpation of the base of the tongue and tonsils. Only the left tonsil is found to be discreetly hardened, otherwise there is no suspicious mass, either by inspection or palpation. Tonsillectomy on the right side first. To do this, grasp the upper pole of the tonsil and dislodge it. Then make a parauvular mucosal incision and extend it caudally. Successive dissection along the tonsil capsule from the upper pole to the lower pole using raspa and scissors. Occasional bipolar coagulation. Separation of the tonsil at the lower pole after extensive bipolar coagulation. Inspection of the wound bed using an angled mirror. Isolated bipolar coagulation at the lower tonsil pole, then no further bleeding here. Isolated bleeding at the upper tonsil pole, also here biopolar coagulation, then no further bleeding. Insertion of hydrogen swabs on the right side and turning to the left side. Here too, grasp the tonsil at the upper pole and dislodge it. This is somewhat more difficult than on the opposite side. Parauvular mucosal incision and extension of the same with an approx. 0.5 cm wide margin. Now dissect the upper pole of the tonsil capsule. After a short time, it becomes apparent that this is more difficult and the upper tonsil pole appears to be cemented to the base. Demonstration of findings on . Further tonsillectomy on the left using scissors and raspa. In the lower third, the preparation is much more successful, in the upper third an attempt was made to resect the adhesions and hardening completely in toto. The tonsil is easily removed at the lower pole after extensive bipolar coagulation. Then hemostasis at the lower tonsil pole. Only occasional focal hemostasis at the upper tonsil pole. The tonsil is suture-marked for frozen section. Long long upper cranial tonsillar pole, short long lateral tonsillar margin and short short dorsal cranial tonsillar pole. The right tonsil also goes to the frozen section. The right tonsil is free of carcinoma. On the left tonsil, there is basaloid squamous cell carcinoma at the cranial tonsillar pole up to the medial margin, matching the lymph node metastasis. The lateral tonsil margin and the dorsal cranial tonsil pole were free. Subsequent demonstration of findings at and . Subsequent resection by . First, a posterior resection is performed on the posterior palatal arch medially and a posterior resection on the anterior palatal arch laterally and at the base of the wound caudally. These resections are sent for final histology. Subsequently, marginal samples are taken and sent for frozen section, namely the medial posterior palatal arch, lateral anterior palatal arch and cranial anterior palatal arch. In addition, the cranial wound bed and caudal wound bed as well as the caudal margin. The frozen section also shows squamous cell carcinoma on the posterior palatal arch medially and, according to the pathologist, a carcinoma in situ in the cranial wound bed and non-assessable tissue in the caudal wound bed. For this reason, subsequently performs another extensive resection in all areas of the previous margin samples. A final marginal sample is therefore taken from the caudal wound bed, a second resection is performed in the cranial wound bed, a final marginal sample is taken from the cranial wound bed, a second resection is performed on the medial posterior palatal arch and, last but not least, a final marginal sample is taken from the medial posterior palate. The areas of the previously described R1 resection are thus covered and a macroscopic R0 situation is present, resulting in the prolapse of fatty tissue at the lateral tonsillar margin, which is coagulated. However, there is no fistula in the direction of the neck. The posterior palatal arch is ultimately only marginally protruding. An adapting suture is placed in the area of the soft palate. The samples are now sent for final histology. Hemostasis is performed. No further signs of bleeding here. Unblocking after sufficient waiting time. Repeated inspection. No further bleeding here. A nasogastric tube is inserted and its position checked. Air can be auscultated in the stomach and gastric juice aspirated. Now turn to neck dissection on the left: The surgeon first positions the head. Then infiltration anesthesia with 6 ml Ultracaine 2% in the area of the planned incision. Then skin disinfection and sterile draping of the surgical area. Now mark the skin incision, which curves along the anterior edge of the sternocleidomastoid, and mark landmarks on the mastoid, mandible and jugulum. Now cut through the skin and subcutaneous tissue. Then cut and expose the platysma. The external jugular vein is cut in the process. Then expose the sternocleidomastoid, the omohyoid, the submandibular gland and the anterior and posterior digaster venter. Subsequently, clearing of the anterior medial neck dissection specimen while sparing the facial vein, the superior thyroid artery, the hypoglossal nerve, the internal jugular vein and the cervical vein. Subsequent visualization of the accessorius nerve. Larger veins are ligated individually. Subsequent clearing of the accessory triangle. Dissection of the internal jugular vein and exposure of the external and internal carotid arteries and exposure of the vagus. Now clearing of the lateral neck triangle from level IV to level II with transition to level Va. Careful protection of the cervical plexus branches. Subsequent wound irrigation with Ringer and wound inspection. Isolated bleeding here. These are stopped using bipolar coagulation. Now no further bleeding. Wound irrigation again. Now dry wound conditions. Subsequent insertion of a 10-gauge Redon drain and careful two-layer wound closure. Head repositioning by the surgeon and completion of the procedure without complications. Conclusion: suspected cT1 cN2b tonsillar carcinoma on the left. Neck dissection from level II to level Va and tumor tonsillectomy on the left. The first resection revealed focal squamous cell carcinoma on the posterior medial palatal arch as well as CIS in the cranial wound bed and non-assessable conditions in the caudal wound bed. For this reason, a second resection was performed with final margin samples, which were sent for final histology. In R0, the swallowing function should be awaited; if this does not appear sufficient, flap coverage is possible before adjuvant therapy. In the R1 situation, presentation at the tumor conference and planning of a subsequent resection with flap coverage and discussion of a contralateral neck dissection. \ No newline at end of file diff --git a/628/InvasionFront_CD3_block10_x5_y11_patient628_0.json b/628/InvasionFront_CD3_block10_x5_y11_patient628_0.json new file mode 100644 index 0000000000000000000000000000000000000000..76a266d2b097f9ea9dedc5fd0a9ac1751a11e22f --- /dev/null +++ b/628/InvasionFront_CD3_block10_x5_y11_patient628_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16665.6, + "Centroid Y µm": 33968.1, + "Num Detections": 20807, + "Num Negative": 20415, + "Num Positive": 392, + "Positive %": 1.884, + "Num Positive per mm^2": 160.81 + } +} \ No newline at end of file diff --git a/628/InvasionFront_CD3_block10_x6_y11_patient628_1.json b/628/InvasionFront_CD3_block10_x6_y11_patient628_1.json new file mode 100644 index 0000000000000000000000000000000000000000..685b13beafc19a67f05cf7571c7703d1389e2741 --- /dev/null +++ b/628/InvasionFront_CD3_block10_x6_y11_patient628_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19016.3, + "Centroid Y µm": 34461.0, + "Num Detections": 24350, + "Num Negative": 21932, + "Num Positive": 2418, + "Positive %": 9.93, + "Num Positive per mm^2": 999.45 + } +} \ No newline at end of file diff --git a/628/InvasionFront_CD8_block10_x5_y11_patient628_0.json b/628/InvasionFront_CD8_block10_x5_y11_patient628_0.json new file mode 100644 index 0000000000000000000000000000000000000000..82bfca3935f4906eb7dd380475b649a9ede78dc6 --- /dev/null +++ b/628/InvasionFront_CD8_block10_x5_y11_patient628_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17515.7, + "Centroid Y µm": 33982.0, + "Num Detections": 20809, + "Num Negative": 20585, + "Num Positive": 224, + "Positive %": 1.076, + "Num Positive per mm^2": 92.1 + } +} \ No newline at end of file diff --git a/628/InvasionFront_CD8_block10_x6_y11_patient628_1.json b/628/InvasionFront_CD8_block10_x6_y11_patient628_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6c14d91c1cc2859af48b7ff7d0a1333c5e5b751 --- /dev/null +++ b/628/InvasionFront_CD8_block10_x6_y11_patient628_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19939.4, + "Centroid Y µm": 34032.0, + "Num Detections": 23764, + "Num Negative": 22364, + "Num Positive": 1400, + "Positive %": 5.891, + "Num Positive per mm^2": 596.76 + } +} \ No newline at end of file diff --git a/628/TumorCenter_CD3_block10_x5_y11_patient628_0.json b/628/TumorCenter_CD3_block10_x5_y11_patient628_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b01e70afc0e7279c0e50bfa07e1e3392c8ccb851 --- /dev/null +++ b/628/TumorCenter_CD3_block10_x5_y11_patient628_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 26735.8, + "Num Detections": 21981, + "Num Negative": 20769, + "Num Positive": 1212, + "Positive %": 5.514, + "Num Positive per mm^2": 576.33 + } +} \ No newline at end of file diff --git a/628/TumorCenter_CD3_block10_x6_y11_patient628_1.json b/628/TumorCenter_CD3_block10_x6_y11_patient628_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f03ee3fc00218981e6f8422897a2b05199d0837 --- /dev/null +++ b/628/TumorCenter_CD3_block10_x6_y11_patient628_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21188.8, + "Centroid Y µm": 26660.9, + "Num Detections": 22714, + "Num Negative": 21913, + "Num Positive": 801, + "Positive %": 3.526, + "Num Positive per mm^2": 374.8 + } +} \ No newline at end of file diff --git a/628/TumorCenter_CD8_block10_x5_y11_patient628_0.json b/628/TumorCenter_CD8_block10_x5_y11_patient628_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a61c1fa1c90c01b070beb2edc2be6eddcaf257c8 --- /dev/null +++ b/628/TumorCenter_CD8_block10_x5_y11_patient628_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 27610.4, + "Num Detections": 24541, + "Num Negative": 24285, + "Num Positive": 256, + "Positive %": 1.043, + "Num Positive per mm^2": 117.32 + } +} \ No newline at end of file diff --git a/628/TumorCenter_CD8_block10_x6_y11_patient628_1.json b/628/TumorCenter_CD8_block10_x6_y11_patient628_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f8f3c4b7fd9251f0db35272285762618ec60a873 --- /dev/null +++ b/628/TumorCenter_CD8_block10_x6_y11_patient628_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 27510.4, + "Num Detections": 23817, + "Num Negative": 23514, + "Num Positive": 303, + "Positive %": 1.272, + "Num Positive per mm^2": 137.54 + } +} \ No newline at end of file diff --git a/628/history_text.txt b/628/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0037b69cc249defad4adacf803ae79cfabcf298d --- /dev/null +++ b/628/history_text.txt @@ -0,0 +1 @@ +Patient with external histology of a squamous cell carcinoma. As this needs to be confirmed again, a test biopsy with a frozen section is performed on the ward before the start of surgery. decides on squamous cell carcinoma. \ No newline at end of file diff --git a/628/icd_codes.txt b/628/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/628/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/628/ops_codes.txt b/628/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e53ac30f0cec9c46431326b3c4c32eea86565661 --- /dev/null +++ b/628/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Transorale Tumortonsillektomie[5-281.2 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/628/patient_clinical_data.json b/628/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0c9840145f8e04488cf8990479ceec0b2835b4c2 --- /dev/null +++ b/628/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 40, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/628/patient_pathological_data.json b/628/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..421a34bb0728bdffafb3b32457dc87c40f145b1e --- /dev/null +++ b/628/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "628", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/628/surgery_description.txt b/628/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..13dd752d4b00a4e154f97a9c574e27ef344ac5fb --- /dev/null +++ b/628/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy diff --git a/628/surgery_report.txt b/628/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c0544be9074444418aa95dc6864c8ce8a167de7 --- /dev/null +++ b/628/surgery_report.txt @@ -0,0 +1 @@ +Intraoperatively, before intubation, positioning of the laryngeal entrance with the laryngoscope. Entering with the 0 degree optics and endoscopy of the larynx and trachea. This is inconspicuous. The visible main bronchi are clear. After intubation, perform a microlaryngoscopy: adjust the small bore tube. Vocal folds, anterior/posterior commissure, supraglottic region inconspicuous. Pharyngoscopy: piriform sinus on both sides, postcricoid region, posterior pharyngeal wall, lateral pharyngeal walls and esophageal entrance clear. Finally, a flexible esophagoscopy was performed: the esophagoscope was easily advanced into the stomach. Inconspicuous conditions there. No evidence of a second tumor on retraction. Now adjusting the tonsil barring device. An exophytically growing tumor can be seen in the area of the right tonsil, which also extends anteriorly towards the base and edge of the tongue. Grasp the right tonsil with the grasping forceps and begin dissection at the cranial margin with scissors and monopolar coagulation. Dissection in the healthy tissue behind the tonsil. The posterior palatal arch is preserved. Further preparation towards the alveolar ridge and anteriorly towards the tongue. Part of the base of the tongue and the tongue are included. Sharp dissection here with monopolar coagulation. Finally, the tumor with the tonsil and parts of the tongue and the base of the tongue are completely incised and extirpated in toto. Circular margin samples are taken and sent for frozen section. These are found to be tumor-free. Overall, an R0 situation can be assumed for a cT2 tonsil/oropharyngeal carcinoma. After resection of the tumor, it can be seen that large parts of the submandibular gland are exposed. Individual injecting vessels were previously bipolarly coagulated and are now clipped again. Application of TachoSil. Consultation of . It is decided not to perform a neck dissection at this time. This must be performed in 14 days after the wound has started to heal. The submandibular gland must be preserved for coverage. In addition, individual vascular stumps are treated with clips. The patient is transferred to the intensive care unit for postoperative monitoring and should remain there over the weekend. In the event of post-operative bleeding, tamponade directly in the tonsil lumen. This should be clinically feasible. \ No newline at end of file diff --git a/629/InvasionFront_CD3_block2_x3_y5_patient629_0.json b/629/InvasionFront_CD3_block2_x3_y5_patient629_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8de102678a6f6a518283bb5681e42d8666450e1a --- /dev/null +++ b/629/InvasionFront_CD3_block2_x3_y5_patient629_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 25936.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/InvasionFront_CD3_block2_x4_y5_patient629_1.json b/629/InvasionFront_CD3_block2_x4_y5_patient629_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c419c599acaf84d6467189643bb463cdad0bc914 --- /dev/null +++ b/629/InvasionFront_CD3_block2_x4_y5_patient629_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 26036.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/InvasionFront_CD8_block2_x3_y5_patient629_0.json b/629/InvasionFront_CD8_block2_x3_y5_patient629_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ab195b69f5763d9fd0fb8b4e67c479586a72312 --- /dev/null +++ b/629/InvasionFront_CD8_block2_x3_y5_patient629_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12468.4, + "Centroid Y µm": 13517.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/InvasionFront_CD8_block2_x4_y5_patient629_1.json b/629/InvasionFront_CD8_block2_x4_y5_patient629_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c46092c1c7321b6d5efb8a3ea86915b1fb9ebc3 --- /dev/null +++ b/629/InvasionFront_CD8_block2_x4_y5_patient629_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15167.0, + "Centroid Y µm": 13617.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/TumorCenter_CD3_block2_x3_y5_patient629_0.json b/629/TumorCenter_CD3_block2_x3_y5_patient629_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b6b5446566e5c432f166a843d915783f35b8354 --- /dev/null +++ b/629/TumorCenter_CD3_block2_x3_y5_patient629_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11369.0, + "Centroid Y µm": 12093.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/TumorCenter_CD3_block2_x4_y5_patient629_1.json b/629/TumorCenter_CD3_block2_x4_y5_patient629_1.json new file mode 100644 index 0000000000000000000000000000000000000000..256406f09b501eef887180f50fc28c0618d2f8b2 --- /dev/null +++ b/629/TumorCenter_CD3_block2_x4_y5_patient629_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 12218.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/TumorCenter_CD8_block2_x3_y5_patient629_0.json b/629/TumorCenter_CD8_block2_x3_y5_patient629_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e59c712fbef089be90f9c32e0b4355c072d4e04 --- /dev/null +++ b/629/TumorCenter_CD8_block2_x3_y5_patient629_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 12218.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/TumorCenter_CD8_block2_x4_y5_patient629_1.json b/629/TumorCenter_CD8_block2_x4_y5_patient629_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ecdcb36265399064793ac704a7c52f2679707de --- /dev/null +++ b/629/TumorCenter_CD8_block2_x4_y5_patient629_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 12168.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/629/history_text.txt b/629/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/629/icd_codes.txt b/629/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8eb6cd7fac5c3b99c69823658dd38a1c2ee7589f --- /dev/null +++ b/629/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 L] \ No newline at end of file diff --git a/629/ops_codes.txt b/629/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc56d6d4d834a2c5b45b58940cbd4f53ed3216e1 --- /dev/null +++ b/629/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Anlegen einer PEG durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 R] Sonstige Laryngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.x4 ] Transplantat[5-295.14 ] Plastische Rekonstruktion mit fasziokutanem Lappen Oberschenkel und Knie[5-857.08 R] Vollhautdeckung großflächig Empfängerstelle Hals[5-902.65 ] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/629/patient_clinical_data.json b/629/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dee9e2c9a0ec4f5629977b2561e1701b46c0670a --- /dev/null +++ b/629/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 54, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 40, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/629/patient_pathological_data.json b/629/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d4fd729e0e2b11ca8ff6b032ab7f903ff379b86b --- /dev/null +++ b/629/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "629", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/629/surgery_description.txt b/629/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2caba21179fc3f6000cb064eaaaf7746f94daf4 --- /dev/null +++ b/629/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, PEG placement, Defect coverage, Free flap (ALT) diff --git a/629/surgery_report.txt b/629/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..577b22da044a3a2ce0fb9ebce51687d65da5d254 --- /dev/null +++ b/629/surgery_report.txt @@ -0,0 +1 @@ +: After induction and intubation by the anesthesiology colleagues, the primary tumor region was first inspected for extensive cervical metastasis with broad skin infiltration and a clear inflammatory reaction in the surrounding area. Overall, the mass was partly necrotic and appeared liquid, measuring over 10 cm in total. The Kleinsasser tube was inserted under dental protection and the inconspicuous oral cavity and oropharynx were inspected. An uneven mucosa can now be seen at the entrance to the left piriform sinus, which merges into an ulcerated tumor in the area of the left piriform sinus. The uneven and partly slightly elevated mucosa moves to the posterior wall of the hypopharynx, just not reaching the midline and caudally free esophageal entrance. The tumor infiltrates the hemilarynx via the medial piriform sinus wall and breaks through it here and appears submucosally in the area of the pocket fold. The glottic plane itself and the subglottic region are exposed. The patient is now repositioned and prepared. Incision of the monstrous mass on the left cervical side with sufficient safety distance, completion of the incision to the right in the sense of an apron flap. Dissection of the healthy skin in the form of an apron flap. Detachment of the mass which broadly infiltrates and destroys the sternocleidomastoid muscle, also resection in case of infiltration of the omohyoid muscle. Caudal visualization of the cervical vascular sheath. The internal jugular vein can already be seen here with significantly reduced flow, with clear infiltration cranially. This is therefore removed. Exposure and preservation of the common carotid artery and vagus nerve. Cranially, the mass also infiltrates the submandibular gland and the digastric muscle. Sectional exposure of the ramus marginalis mandibulae. Removal of several small nodular lymph nodes. Extirpation of the gland with protection and exposure of the lingual nerve and ligation of the excretory duct. Complete resection of the cervical plexus branches, the accessorius nerve is also infiltrated. Separation of the internal jugular vein and the cranial sternocleidomastoid muscle. Now dissection of the carotid artery walled around the MCC at a good 180°. Further dissection reveals a clear infiltration of the vagus nerve. This is therefore resected. The hypoglossal nerve can be separated from the mass, here no infiltration. There is now an infiltration of the external carotid artery up to just before the bulb. The internal carotid artery is free. Separation of the external carotid artery close to the bulb and removal of a marginal sample. This is shown to be tumor-free in the frozen section diagnosis. Therefore, in sano resection of the carotid artery with an overall extensive surrounding wall and removal of the mass in toto which, however, is clearly inflammatory. Intraoperative drainage of serous fluid in the sense of extensive necrosis, overall vulnerable conditions. Subsequent right-sided release of the hemilarynx. Exposure of the thyroid cartilage....... Release of the right-sided piriform sinus. The left-sided resection of the hyoid was already performed during the metastasis resection. Now removal of the residual hyoid. Entering enorally at the level of the vallecula. Successive widening of the pharyngotomy sparingly along the right aryepiglottic fold. Now a good overview of the tumor. Incision of the tumor, which has clearly quieter mucosal extensions in the periphery with a safety margin of approx. 1.5 cm. Resection to just before the middle of the posterior hypopharyngeal wall. Deposition at the esophageal entrance. No more suspicious conditions here. The tumor is now completely covered with marginal samples in the mucosal area, the entire base is radically removed in the course of the neck dissection. The frozen section diagnosis now shows the invasive carcinoma R0 resected, circumscribed Cis in the area of the posterior hypopharyngeal wall. A resection is therefore performed here and a final marginal specimen removed, so that the overall situation is R0. Now to the harvesting of the antero-lateral thigh graft. After identification of the landmarks, doppler sonographic identification of the main perforator and 2 secondary perforators. Configuration of the graft to cover the pharyngeal defect due to the extensive hypopharyngeal resection in this case, as well as a skin defect measuring approx. 13 x 7 cm. A graft measuring a total of 27 x 8 cm was removed as a two-incision flap. Medial incision, separation of the extensive fat layer. Identification of the rectus femoris muscle. Subfascial release and exposure of the regularly configured pedicle vessel. Widening of the incision. Identification of the main perforator and two secondary perforators. Dissection of the perforators with circumscribed musculocutaneous course. Isolation on the perforators. Removal of the fascia lata to protect the perforators, otherwise it is left in place. Complete cutting of the graft. Isolation on the vascular pedicle and placement of the excellent vital graft after thinning out the lateral ends, paying careful attention to the vascular fat layer. Finally, vital graft and placement of the pedicle vessel. Subsequent insertion of 10 redon drains and careful multi-layer strong wound closure. Neck dissection on the right: visualization of the sternocleidomastoid muscle. Exposure of the accessorius nerve, the submandibular gland and the digastric muscle. Then release of the neck preparation IIa to Va while sparing the plexus branches; the internal jugular vein and the cervical vascular sheath were previously exposed. The superior thyroid, facial and lingual arteries were preserved, as was the facial vein. Insertion of the transplant. First, the graft is sutured into the hypopharynx with the smaller skin island. To do this, start at the base of the tongue and successively suture in the entire graft portion intended for the pharynx. This is successful without any problems. Then reposition and advance the microscope and dissect the arterial vessels using . The connective tissue is removed from the superior thyroid artery and the facial artery. Ultimately, there is very good flow in the superior thyroid artery. This is flushed with xylocaine by and temporarily clamped. The vascular anastomosis is then performed by . First suture the artery, this is successful without any problems. Dissection of the veins, the graft veins are extremely small and have many valves. It is therefore difficult to perform the venous anastomosis using a coupler. Finally, it is successful and the graft shows very good perfusion and also very good reperfusion. Then insertion of a Redon drain on the right side and a flap on the left side and fitting the second skin island of the graft first into the tracheostoma, then into the large skin defect on the neck. \ No newline at end of file diff --git a/630/InvasionFront_CD3_block21_x5_y3_patient630_0.json b/630/InvasionFront_CD3_block21_x5_y3_patient630_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cdfb3212bc930b2f34908999edca1b23b8d305a3 --- /dev/null +++ b/630/InvasionFront_CD3_block21_x5_y3_patient630_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 18215.4, + "Num Detections": 23241, + "Num Negative": 22703, + "Num Positive": 538, + "Positive %": 2.315, + "Num Positive per mm^2": 221.9 + } +} \ No newline at end of file diff --git a/630/InvasionFront_CD3_block21_x6_y3_patient630_1.json b/630/InvasionFront_CD3_block21_x6_y3_patient630_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6759f7e9e6c8870260e125c4c2b1c4f75fb90166 --- /dev/null +++ b/630/InvasionFront_CD3_block21_x6_y3_patient630_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21763.5, + "Centroid Y µm": 18415.2, + "Num Detections": 15820, + "Num Negative": 15231, + "Num Positive": 589, + "Positive %": 3.723, + "Num Positive per mm^2": 322.57 + } +} \ No newline at end of file diff --git a/630/InvasionFront_CD8_block21_x5_y3_patient630_0.json b/630/InvasionFront_CD8_block21_x5_y3_patient630_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8ed92844994cb9dca4fa858f0706c7e48971e2b8 --- /dev/null +++ b/630/InvasionFront_CD8_block21_x5_y3_patient630_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 7321.1, + "Num Detections": 24404, + "Num Negative": 23918, + "Num Positive": 486, + "Positive %": 1.991, + "Num Positive per mm^2": 191.13 + } +} \ No newline at end of file diff --git a/630/InvasionFront_CD8_block21_x6_y3_patient630_1.json b/630/InvasionFront_CD8_block21_x6_y3_patient630_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e1095a9ca00b952976444fdf6c2f324449b025ac --- /dev/null +++ b/630/InvasionFront_CD8_block21_x6_y3_patient630_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 7221.2, + "Num Detections": 21671, + "Num Negative": 21146, + "Num Positive": 525, + "Positive %": 2.423, + "Num Positive per mm^2": 204.6 + } +} \ No newline at end of file diff --git a/630/TumorCenter_CD3_block21_x5_y3_patient630_0.json b/630/TumorCenter_CD3_block21_x5_y3_patient630_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c4fa8d247c546c44b91ed6a0108749a77f5247bb --- /dev/null +++ b/630/TumorCenter_CD3_block21_x5_y3_patient630_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16468.4, + "Centroid Y µm": 9858.8, + "Num Detections": 15285, + "Num Negative": 15126, + "Num Positive": 159, + "Positive %": 1.04, + "Num Positive per mm^2": 70.5 + } +} \ No newline at end of file diff --git a/630/TumorCenter_CD3_block21_x6_y3_patient630_1.json b/630/TumorCenter_CD3_block21_x6_y3_patient630_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a2b20b37f401c9d848aed4adbb4cf38f919e1a2 --- /dev/null +++ b/630/TumorCenter_CD3_block21_x6_y3_patient630_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19157.6, + "Centroid Y µm": 9788.6, + "Num Detections": 16066, + "Num Negative": 15990, + "Num Positive": 76, + "Positive %": 0.473, + "Num Positive per mm^2": 37.23 + } +} \ No newline at end of file diff --git a/630/TumorCenter_CD8_block21_x5_y3_patient630_0.json b/630/TumorCenter_CD8_block21_x5_y3_patient630_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1d78d5b9b09b83d125dcd53e2f8a352db98e836 --- /dev/null +++ b/630/TumorCenter_CD8_block21_x5_y3_patient630_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 22438.1, + "Num Detections": 21493, + "Num Negative": 21325, + "Num Positive": 168, + "Positive %": 0.7816, + "Num Positive per mm^2": 65.69 + } +} \ No newline at end of file diff --git a/630/TumorCenter_CD8_block21_x6_y3_patient630_1.json b/630/TumorCenter_CD8_block21_x6_y3_patient630_1.json new file mode 100644 index 0000000000000000000000000000000000000000..88e38125e43533ff2328697e0fa36a10f019f917 --- /dev/null +++ b/630/TumorCenter_CD8_block21_x6_y3_patient630_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21763.5, + "Centroid Y µm": 22613.0, + "Num Detections": 18362, + "Num Negative": 18233, + "Num Positive": 129, + "Positive %": 0.7025, + "Num Positive per mm^2": 59.92 + } +} \ No newline at end of file diff --git a/630/history_text.txt b/630/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bb7adbc747e33655a400a8ab5510d5d8edbe3a11 --- /dev/null +++ b/630/history_text.txt @@ -0,0 +1 @@ +The patient had a history of hoarseness since the end of 2012. The panendoscopy performed <2013> revealed a cT1b glottic laryngeal carcinoma on the right side. Decision to take the above measures. \ No newline at end of file diff --git a/630/icd_codes.txt b/630/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/630/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/630/ops_codes.txt b/630/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ef766807aca11f0b6cda2f397c22ca448986c7e --- /dev/null +++ b/630/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/630/patient_clinical_data.json b/630/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c45cc172db12946b75dff3e3baf277d2a01ed7d5 --- /dev/null +++ b/630/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 46, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/630/patient_pathological_data.json b/630/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ec8498a6827b6e8d1e8a17fcede08ca43417874d --- /dev/null +++ b/630/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "630", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.5 +} \ No newline at end of file diff --git a/630/surgery_description.txt b/630/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5462faa1f571443b90f96a41d612b40acfcafecc --- /dev/null +++ b/630/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection diff --git a/630/surgery_report.txt b/630/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..503f0d7152dc4f504a56dc5f23ebf2b6abab162d --- /dev/null +++ b/630/surgery_report.txt @@ -0,0 +1 @@ +First, after induction of anesthesia by the anesthesia colleagues, a rigid tracheoscopy is performed using O° optics in the area of the trachea up to the carina. Subsequent problem-free endotracheal transoral intubation with a laser tube and positioning of the patient by the surgeon. Entry into the endolarynx with the Kleinsasser B-tube. An exophytic mass was found starting at the transition from the posterior to the middle third of the right vocal fold, affecting the entire vocal fold, reaching the anterior commissure and infiltrating the most anterior part of the left vocal fold via the midline. The supraglottis and subglottis were unremarkable. Thus, cT1b glottic laryngeal carcinoma on the right was emphasized. The remaining left vocal fold was unremarkable. With very good adjustability, decision to perform transoral microscopically controlled laser resection. Demonstration of findings on . Setting the CO2 laser to continuous mode with a power of 6 watts. Focusing the laser beam and moving around the pre-existing mass from the posterior starting point under microscopic control of the safety distance. A circumscribed exposure of the thyroid cartilage occurs in the area of the anterior commissure. Circumventing the mass in the anterior third of the left vocal fold and depositing the tumor specimen which is sent in for final histology (short short posterior, short long superior towards the pocket fold, long long anterior towards the anterior commissure). Five marginal samples were then taken, posterior, superior towards the pocket fold, inferior towards the subglottic, anterior commissure, anterior left vocal fold. All marginal samples were sent for frozen section examination. According to the pathologists, all marginal samples were found to be tumor-free. Only in the inferior border sample in the subglottic direction and on the left vocal fold could no statement be made in the frozen section regarding the detection of dysplasia. In order to keep the glottic defect as small as possible and in view of the microscopically unremarkable subglottic region and left vocal fold anteriorly, post-resection was not performed and the final histology should be awaited. Hemostasis with a swab soaked in Otriven. Repeated inspection and, if there was little bleeding, completion of the procedure without complications. \ No newline at end of file diff --git a/631/InvasionFront_CD3_block18_x5_y2_patient631_0.json b/631/InvasionFront_CD3_block18_x5_y2_patient631_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b6469866ece1edb8c69315b9afb0229100aff70 --- /dev/null +++ b/631/InvasionFront_CD3_block18_x5_y2_patient631_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16966.0, + "Centroid Y µm": 9869.8, + "Num Detections": 16761, + "Num Negative": 15706, + "Num Positive": 1055, + "Positive %": 6.294, + "Num Positive per mm^2": 505.29 + } +} \ No newline at end of file diff --git a/631/InvasionFront_CD3_block18_x6_y2_patient631_1.json b/631/InvasionFront_CD3_block18_x6_y2_patient631_1.json new file mode 100644 index 0000000000000000000000000000000000000000..734b87884bab5d1c29fc866815cb9e3b202b07c3 --- /dev/null +++ b/631/InvasionFront_CD3_block18_x6_y2_patient631_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 9869.8, + "Num Detections": 20132, + "Num Negative": 18233, + "Num Positive": 1899, + "Positive %": 9.433, + "Num Positive per mm^2": 846.57 + } +} \ No newline at end of file diff --git a/631/InvasionFront_CD8_block18_x5_y2_patient631_0.json b/631/InvasionFront_CD8_block18_x5_y2_patient631_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b6f5fcd6019dba855053d6e01d29c783c1f29072 --- /dev/null +++ b/631/InvasionFront_CD8_block18_x5_y2_patient631_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16542.9, + "Centroid Y µm": 13217.2, + "Num Detections": 16121, + "Num Negative": 15073, + "Num Positive": 1048, + "Positive %": 6.501, + "Num Positive per mm^2": 514.96 + } +} \ No newline at end of file diff --git a/631/InvasionFront_CD8_block18_x6_y2_patient631_1.json b/631/InvasionFront_CD8_block18_x6_y2_patient631_1.json new file mode 100644 index 0000000000000000000000000000000000000000..55dd94b9491db8a4cb2fc08afd25bddfb8d89f2d --- /dev/null +++ b/631/InvasionFront_CD8_block18_x6_y2_patient631_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19046.3, + "Centroid Y µm": 13294.9, + "Num Detections": 22394, + "Num Negative": 20623, + "Num Positive": 1771, + "Positive %": 7.908, + "Num Positive per mm^2": 696.99 + } +} \ No newline at end of file diff --git a/631/TumorCenter_CD3_block18_x5_y2_patient631_0.json b/631/TumorCenter_CD3_block18_x5_y2_patient631_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7df88150dfeeb635d63e29553ca76831360dfab2 --- /dev/null +++ b/631/TumorCenter_CD3_block18_x5_y2_patient631_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 5072.3, + "Num Detections": 26704, + "Num Negative": 26218, + "Num Positive": 486, + "Positive %": 1.82, + "Num Positive per mm^2": 186.11 + } +} \ No newline at end of file diff --git a/631/TumorCenter_CD3_block18_x6_y2_patient631_1.json b/631/TumorCenter_CD3_block18_x6_y2_patient631_1.json new file mode 100644 index 0000000000000000000000000000000000000000..af66ffc0df0a4ff643f2bafec353ef6bc3ec6fae --- /dev/null +++ b/631/TumorCenter_CD3_block18_x6_y2_patient631_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 5172.3, + "Num Detections": 26280, + "Num Negative": 25453, + "Num Positive": 827, + "Positive %": 3.147, + "Num Positive per mm^2": 315.86 + } +} \ No newline at end of file diff --git a/631/TumorCenter_CD8_block18_x5_y2_patient631_0.json b/631/TumorCenter_CD8_block18_x5_y2_patient631_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aeb18d942c388dd5764c18a5474c7f87bf3b8095 --- /dev/null +++ b/631/TumorCenter_CD8_block18_x5_y2_patient631_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 5572.0, + "Num Detections": 25688, + "Num Negative": 23132, + "Num Positive": 2556, + "Positive %": 9.95, + "Num Positive per mm^2": 978.71 + } +} \ No newline at end of file diff --git a/631/TumorCenter_CD8_block18_x6_y2_patient631_1.json b/631/TumorCenter_CD8_block18_x6_y2_patient631_1.json new file mode 100644 index 0000000000000000000000000000000000000000..24c08e1a72130f7c6bd63b15736a5a123ce9bc72 --- /dev/null +++ b/631/TumorCenter_CD8_block18_x6_y2_patient631_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 5597.0, + "Num Detections": 25824, + "Num Negative": 23267, + "Num Positive": 2557, + "Positive %": 9.902, + "Num Positive per mm^2": 981.14 + } +} \ No newline at end of file diff --git a/631/history_text.txt b/631/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/631/icd_codes.txt b/631/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/631/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/631/ops_codes.txt b/631/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d2680d1eaf32d07e83e7ca419a49ec9f2438126 --- /dev/null +++ b/631/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie[5-312.0 ] Entnahme von Spalthaut des Unterschenkels[5-901.0f R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/631/patient_clinical_data.json b/631/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..024f8f738f2904ab0ab7c6916b82144e7c48a504 --- /dev/null +++ b/631/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/631/patient_pathological_data.json b/631/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d8400e3859a7c9d32a9dd023af6f70cd27f609b7 --- /dev/null +++ b/631/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "631", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/631/surgery_description.txt b/631/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..855b9086da9d9167717b45f3e4a872c302ccdc9b --- /dev/null +++ b/631/surgery_description.txt @@ -0,0 +1 @@ +Laryngo-/Pharyngectomy, Bilateral neck dissection I-IV, Free flap (Radial) diff --git a/631/surgery_report.txt b/631/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..615b43a0d5eaf27e41381e2c1a96e7c6652a0b90 --- /dev/null +++ b/631/surgery_report.txt @@ -0,0 +1 @@ +First, skin disinfection and infiltration with local anesthetic containing adrenaline. Then marking and setting of the apron flap, whereby the tracheostoma is included in the apron flap. Dissection of the apron flap cranially to beyond the hyoid bone. Now start with the neck dissection on the right side. Here, regions II to V are removed while sparing all non-lymphatic structures. However, a lymph node metastasis can be seen around the internal jugular vein, which can just be dissected away from the vessel in a healthy layer macroscopically. Identification and dissection of the superior thyroid artery, which must be removed at the upper thyroid pole. Then dissection of the carotid artery, which is dissected laterally from the laryngeal skeleton. Then incision of the constrictor pharyngis muscle at the lateral edge of the thyroid cartilage and release of the piriform sinus on the right side as far as possible. On palpation, the tumor also appears to have partially grown into this area. Release of the lateral horn of the hyoid bone and separation of the suprahyoid muscles up to the middle. Then cut the straight muscles of the neck, pass under the thyroid isthmus and expose the anterior wall of the trachea up to the already existing tracheostoma. Then transition to the opposite side. Similar conditions here in principle. However, it can be seen that the left neck is in principle a single large metastasis extending from region IIa to region V. This is also macroscopically dissected in a healthy layer of the internal jugular vein, which lies medial and ventral to the metastasis. Resection of the metastasis en bloc reveals the brachial plexus. In addition, the phrenic nerve can now be seen to pass through the middle of the caudal metastasis, so that it must be removed. The metastasis is then developed retroclavicularly from the caudal side. This exposes the thoracic duct, which is also opened. It is then grasped and ligated. Finally, the metastasis can be completely removed from the caudal side. The site of the thoracic duct is also ligated so that no further lymphatic leakage can be seen clinically. Then dissection of the superior thyroid artery, which is extremely small in caliber. Therefore, dissection of the external carotid artery cranially and identification and dissection of the facial artery, which is deposited on the mandible and beaten caudally and later used for anastomosis. The suprahyoid muscles are now also removed here. The large tumor is palpable in the area of the lateral hyoid horn and the piriform sinus, so that no further manipulations are performed here. Now dissect the lingual side of the epiglottis up to its upper edge. Cut the pharyngeal mucosa at the upper edge of the epiglottis and enter the pharynx, initially to the right along the upper edge of the glottis. This reveals the tumor on the left. This occupies the entire left pharyngeal wall, spreads to the larynx, spreads endolaryngeally and has already infiltrated the right arytenoid. The tumor is then successively removed on both sides under visual control with an appropriate safety margin. The entire left pharyngeal wall is resected. The resection continues caudally into the esophageal orifice before it can be carried out on the opposite side so that the larynx can then be removed ventrally at the lower edge of the cricoid cartilage. Circumferential mucosal margin sections are then taken from the remaining pharynx, all of which prove to be tumor-free. The small amount of muscle still present in the posterior pharyngeal wall on the left side is also biopsied in the form of marginal incisions, which also prove to be tumor-free. This leaves only a strip of mucosa approx. 2 1/2 to 3 cm wide on the posterior pharyngeal wall. A radial lobe graft was then removed from the left forearm, each 7 cm wide and 10 cm long. After placement of the radial lobe graft, it is sutured into the defect, with the stalk being diverted caudally. The radial artery is then anastomosed to the facial artery. Venous drainage takes place through 2 veins in the end-to-side internal mandibular artery. In the meantime, a 6 x 10 cm split-thickness skin graft is harvested from the right thigh and used to cover the left forearm. Finally, freshening of the tracheostoma by resection of the granulating altered skin. Folding back the apron flap and two-layer wound closure in the usual manner after applying Redon drains on both sides and a flap on the left in the area of the anastomosis. Re-intubation of the patient. Repeated check of the flap, which can be easily seen with a laryngoscope. End of the operation, transfer of the patient to anesthesia. Conclusion: Laryngo-pharyngectomy for large hypopharyngeal laryngeal carcinoma. Cervical metastasis on both sides and mainly on the left. Therefore resection of the phrenic nerve on the left as part of the metastasectomy. Very close relationship of the metastases to the internal jugular vein on both sides. Covering of the defect on the left forearm with split skin from the right thigh. Due to the caudal extension of the resection to the esophageal entrance, the insertion of a provox prosthesis was initially dispensed with, whereby the myotomy was already performed intraoperatively for a possible later secondary Blom-Singer puncture. \ No newline at end of file diff --git a/632/InvasionFront_CD3_block1_x5_y5_patient632_0.json b/632/InvasionFront_CD3_block1_x5_y5_patient632_0.json new file mode 100644 index 0000000000000000000000000000000000000000..714e2c40ecebfdd0b970073cd825f0e5de829e80 --- /dev/null +++ b/632/InvasionFront_CD3_block1_x5_y5_patient632_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16766.1, + "Centroid Y µm": 14417.4, + "Num Detections": 23946, + "Num Negative": 22905, + "Num Positive": 1041, + "Positive %": 4.347, + "Num Positive per mm^2": 399.5 + } +} \ No newline at end of file diff --git a/632/InvasionFront_CD3_block1_x6_y5_patient632_1.json b/632/InvasionFront_CD3_block1_x6_y5_patient632_1.json new file mode 100644 index 0000000000000000000000000000000000000000..48938125ab651de20df28975b97e6946de252590 --- /dev/null +++ b/632/InvasionFront_CD3_block1_x6_y5_patient632_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19364.7, + "Centroid Y µm": 14567.3, + "Num Detections": 20448, + "Num Negative": 19185, + "Num Positive": 1263, + "Positive %": 6.177, + "Num Positive per mm^2": 569.12 + } +} \ No newline at end of file diff --git a/632/InvasionFront_CD8_block1_x5_y5_patient632_0.json b/632/InvasionFront_CD8_block1_x5_y5_patient632_0.json new file mode 100644 index 0000000000000000000000000000000000000000..88496e6a619b2d2018d254e7ac3db46ee4ffbbd3 --- /dev/null +++ b/632/InvasionFront_CD8_block1_x5_y5_patient632_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16766.1, + "Centroid Y µm": 13118.1, + "Num Detections": 22779, + "Num Negative": 21690, + "Num Positive": 1089, + "Positive %": 4.781, + "Num Positive per mm^2": 428.18 + } +} \ No newline at end of file diff --git a/632/InvasionFront_CD8_block1_x6_y5_patient632_1.json b/632/InvasionFront_CD8_block1_x6_y5_patient632_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a1eabaa9a844c51b61cf820fccb865a31e530810 --- /dev/null +++ b/632/InvasionFront_CD8_block1_x6_y5_patient632_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19389.7, + "Centroid Y µm": 13317.9, + "Num Detections": 19554, + "Num Negative": 18271, + "Num Positive": 1283, + "Positive %": 6.561, + "Num Positive per mm^2": 595.72 + } +} \ No newline at end of file diff --git a/632/TumorCenter_CD3_block1_x5_y7_patient632_0.json b/632/TumorCenter_CD3_block1_x5_y7_patient632_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b5d461d42b8b65b458f89df68088040064af3a63 --- /dev/null +++ b/632/TumorCenter_CD3_block1_x5_y7_patient632_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15866.6, + "Centroid Y µm": 17465.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/632/TumorCenter_CD3_block1_x6_y7_patient632_1.json b/632/TumorCenter_CD3_block1_x6_y7_patient632_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b91ea94432cd1a06cfecaa0ba321449f8c74a2c6 --- /dev/null +++ b/632/TumorCenter_CD3_block1_x6_y7_patient632_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18315.3, + "Centroid Y µm": 17290.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/632/TumorCenter_CD8_block1_x5_y5_patient632_0.json b/632/TumorCenter_CD8_block1_x5_y5_patient632_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0b7131eb104aa7825b843a1f0e62ff9b0e6b95b7 --- /dev/null +++ b/632/TumorCenter_CD8_block1_x5_y5_patient632_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 21288.7, + "Num Detections": 7488, + "Num Negative": 7343, + "Num Positive": 145, + "Positive %": 1.936, + "Num Positive per mm^2": 177.86 + } +} \ No newline at end of file diff --git a/632/TumorCenter_CD8_block1_x6_y5_patient632_1.json b/632/TumorCenter_CD8_block1_x6_y5_patient632_1.json new file mode 100644 index 0000000000000000000000000000000000000000..97576160e6fcd6e152f87a716c690aed6e37c20a --- /dev/null +++ b/632/TumorCenter_CD8_block1_x6_y5_patient632_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21413.7, + "Centroid Y µm": 21288.7, + "Num Detections": 15275, + "Num Negative": 15127, + "Num Positive": 148, + "Positive %": 0.9689, + "Num Positive per mm^2": 81.33 + } +} \ No newline at end of file diff --git a/632/history_text.txt b/632/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bcd446c9afd2bbe71551ad03ec7be0a7325bf170 --- /dev/null +++ b/632/history_text.txt @@ -0,0 +1 @@ +The patient has a post pT1 oral floor carcinoma 2007 with neck dissection on both sides, which was covered with a platysmal flap. Adjuvant therapy was not carried out at the time. Now externally confirmed second carcinoma on the palatal arch, therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/632/icd_codes.txt b/632/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa53eb8be9331d2518fcb354f682f2ba6ca6ca6c --- /dev/null +++ b/632/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] Halslymphknotenmetastasen[C77.0 L] \ No newline at end of file diff --git a/632/ops_codes.txt b/632/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ecb6f53f4a391651237be2365bff4506bb52aa00 --- /dev/null +++ b/632/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision am weichen Gaumen[5-272.0 ] Uvulateilresektion[5-272.1 ] Sonstige Exzision und Destruktion (erkrankter) harter und weicher Gaumen[5-272.x ] Selektive Neck dissection in 5 Regionen[5-403.04 B] Permanente Tracheotomie[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme freier Radialis-Lappen[5-858.23 L] Entnahme Spalthaut zur Transplantation Unterarm[5-901.08 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Transplantation fasziokutaner Lappen mit mikrovaskulärer Anastomosierung sonstige[5-858.5x L] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle Hals[5-905.05 ] Lokale Exzision Mundboden[5-273.3 ] Resektion Alveolarkamm mit Rekonstruktion onA[5-771.02 ] Lokale Exzision am Pharynx[5-292.0 ] \ No newline at end of file diff --git a/632/patient_clinical_data.json b/632/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a1064e86be48b835ed93b91102baf03044ca1dbe --- /dev/null +++ b/632/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 47, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/632/patient_pathological_data.json b/632/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..622d955c9278765d7f557fd7d6592e3df2febe1f --- /dev/null +++ b/632/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "632", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 8, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/632/surgery_description.txt b/632/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1843b2f6b60301c002a58439deb84f7042b5d35e --- /dev/null +++ b/632/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/632/surgery_report.txt b/632/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c4d02630b623155a1d8380ac307300daf372134a --- /dev/null +++ b/632/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation transnasally by the anesthesia colleagues. Then sterile washing and draping. Then inspection of the oral cavity and oropharynx. There is an exophytic mass in the area of the soft palate, starting on the left side, which extends over the entire soft palate on the left and 2/3 of the soft palate on the right, including the uvula. The carcinoma spreads to the alveolar ridge and moves towards the glossotonsillar groove and infiltrates a small part of the base of the tongue. Now start with the tumor inspection: First use the monopolar needle to cut around the carcinoma in the soft palate area at a distance of 1-1.5 cm. Careful dissection with removal of the entire soft palate on the left side and 2/3 of the soft palate on the right side. Then resection of the gum from the alveolar ridge of the lower jaw on the left. Here the mass can be easily pushed away from the bone and removal of the posterior palatal arch, mostly on the left side. Removal of the glossotonsillar groove and part of the base of the tongue. Then send the entire preparation for frozen section. In the area of the base of the uvula to the border of the soft palate on the right and in the wound bed in the area of the pterygoid process and in the area of the glossotonsillar groove, carcinoma in situ can still be detected in the frozen section. These areas are resected everywhere and another frozen section is made. Then finally R0. A frozen section can no longer be obtained in the area of the pterygoid process, as this has been resected down to the bone. The pterygoid process is then chiseled off in this area and sent as a marginal sample for final histology. Now measure the defect. The defect is 14 cm from cranial to caudal, including the width of the soft palate. Now transition to neck dissection on the left side. Here, skin incision 2 ˝ QF below the mandible and exposure of the sternocleidomastoid muscle, the omohyoid muscle and the submandibular gland, the cervical vascular sheath, the vagus nerve and the accessory nerve. Free preparation of the internal jugular vein. After previous neck dissection there is hardly any fatty tissue and no visible lymph nodes. Sonography revealed conspicuous lymph nodes in level Ib. The submandibular gland is removed here. The digastric muscle is severed. This automatically leads to the oral cavity area. Clearing of level Ia and b and here several enlarged and also suspicious appearing lymph nodes are found, all of which are also removed. Then neck dissection of the right side by . The skin of the neck is massively scarred due to previous surgery. Horizontally curved skin incision in a skin fold along the former scar. Dissection of the subcutaneous fatty tissue. Exposure of the anterior margin of the sternocleidomastoid. Difficult preparation conditions with scarred conditions in the case of previous surgery. Exposure of the omohyoid muscle. Exposure of the submandibular gland, the accessorius nerve and the cervical vascular sheath. Here too, difficult preparation conditions in the case of previous surgery and scarred, caked conditions. The jugular vein and vagus nerve are scarred with the sternocleidomastoid, but can be detached and spared. The carotid artery can be visualized in depth. In the area of the jugular vein, there is an injury to the same. This is grasped with the Satinsky clamp and sutured over with Vascufil. No further bleeding here. If there is a history of neck dissection on this side, no actual neck preparation can be developed here as no lymphatic tissue can be visualized. Demonstration of findings on and . Some tissue is removed from the caudal part above the omohyoid muscle and sent for histology. Punctual hemostasis using bipolar coagulation. Irrigation of the wound with hydrogen and Ringer's and, if the blood is dry, insertion of a Redon drainage and two-layer wound closure. The radial artery graft is lifted at the same time. Palpation of the radial and ulnar arteries. Marking of the defect, taking into account the duplication on the soft palate. Applying the tourniquets and cutting around the graft. Visualization of the cephalic and basilic veins and the venous star in the crook of the elbow. Exposure of the brachioradialis muscle, the nerve and the superficial ramus of the radial nerve. Unfortunately, one branch cannot be spared as it lies too far below the graft and the size of the graft is so large that the nerve branch cannot be dissected out. This branch must therefore also be removed. Exposure of the radial artery with the accompanying vessels and ligation and transection of these. Lift the graft from the tendon bed and dissect the pedicle up to the crook of the elbow. Lifting the venous confluence and one superficial and one deep vein. Then suture the arm in the usual way. Lifting of split skin from the right thigh to cover the defect on the left forearm and application of a pressure bandage with sewn-on swabs and application of a dorsal forearm splint. In the meantime, the graft is sutured into place. This is very difficult as the mouth opening is severely restricted and can only be opened slightly even under maximum relaxation. The graft is first fixed in the area of the nasopharynx, then folded and sutured in the area of the soft palate. Then further down to the oropharynx area. This is very difficult and has to be done partly transcervically due to the small mouth opening. The graft is finally sutured in completely. Then turn to the vessels of the neck. This is where the superior thyroid artery is located, which is conditioned as a connecting vessel. Only the facial vein is still present as a venous connection vessel. A branch located higher up can no longer be used because the caliber is too small, so the arterial anastomosis is performed as usual and only the facial vein is used as the venous anastomosis without connecting a second accompanying vein. Ultimately, good pedicle pulsation and no venous congestion in the graft. Insertion of a flap and two-layer wound closure. Before insertion of the flap, the tracheotomy is performed in the usual manner and inserted between the 2nd and 3rd tracheal cartilage. A visor tracheotomy and a mucocutaneous anastomosis are performed and at the end of the operation the patient is intubated with a 9-gauge tracheostomy tube. The patient is ventilated and admitted to the intensive care unit. He should continue to receive antibiotics for 24 hours. On the 10th day, please perform an X-ray emesis and build up a diet. Presentation of the patient in the tumor conference after receipt of the histology. \ No newline at end of file diff --git a/633/InvasionFront_CD3_block10_x5_y10_patient633_0.json b/633/InvasionFront_CD3_block10_x5_y10_patient633_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ce78924b44ff666879ed5b27ac30109b9f90b8a7 --- /dev/null +++ b/633/InvasionFront_CD3_block10_x5_y10_patient633_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17098.5, + "Centroid Y µm": 31621.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/InvasionFront_CD3_block10_x6_y10_patient633_1.json b/633/InvasionFront_CD3_block10_x6_y10_patient633_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb76886a55f2b09512086cf0370cbacf6dd8670b --- /dev/null +++ b/633/InvasionFront_CD3_block10_x6_y10_patient633_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19697.2, + "Centroid Y µm": 31864.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/InvasionFront_CD8_block10_x5_y10_patient633_0.json b/633/InvasionFront_CD8_block10_x5_y10_patient633_0.json new file mode 100644 index 0000000000000000000000000000000000000000..55554aa706ed6ec381a2a4575a548149672516be --- /dev/null +++ b/633/InvasionFront_CD8_block10_x5_y10_patient633_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17665.6, + "Centroid Y µm": 31808.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/InvasionFront_CD8_block10_x6_y10_patient633_1.json b/633/InvasionFront_CD8_block10_x6_y10_patient633_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e282396a04ffeb1176854e01e66db2f47712f6f2 --- /dev/null +++ b/633/InvasionFront_CD8_block10_x6_y10_patient633_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20164.3, + "Centroid Y µm": 31883.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/TumorCenter_CD3_block10_x5_y10_patient633_0.json b/633/TumorCenter_CD3_block10_x5_y10_patient633_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f54688bc2ba42bbd985bdf3dd32fd9965ecb2dc4 --- /dev/null +++ b/633/TumorCenter_CD3_block10_x5_y10_patient633_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 24562.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/TumorCenter_CD3_block10_x6_y10_patient633_1.json b/633/TumorCenter_CD3_block10_x6_y10_patient633_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b1c04e0a758c98198b634b1bad73b09314a5edc9 --- /dev/null +++ b/633/TumorCenter_CD3_block10_x6_y10_patient633_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21613.6, + "Centroid Y µm": 24487.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/TumorCenter_CD8_block10_x5_y10_patient633_0.json b/633/TumorCenter_CD8_block10_x5_y10_patient633_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8acd71c6c83b84114991475792927c853f608658 --- /dev/null +++ b/633/TumorCenter_CD8_block10_x5_y10_patient633_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16591.2, + "Centroid Y µm": 25361.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/TumorCenter_CD8_block10_x6_y10_patient633_1.json b/633/TumorCenter_CD8_block10_x6_y10_patient633_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cacdc74eba26339a2a165d8e09ed845b18935413 --- /dev/null +++ b/633/TumorCenter_CD8_block10_x6_y10_patient633_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 25236.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/633/history_text.txt b/633/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/633/icd_codes.txt b/633/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/633/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/633/ops_codes.txt b/633/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b83c9cb92d41d894caba570c84038b2d25d70294 --- /dev/null +++ b/633/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Sonstige Temporäre Tracheostomie[5-311.x ] Totale Laserresektion Zunge transoral sonstige[5-252.0x ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] \ No newline at end of file diff --git a/633/patient_clinical_data.json b/633/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3d27806de67f3a36f119325c3df00973c957f88c --- /dev/null +++ b/633/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 44, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/633/patient_pathological_data.json b/633/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..86240a2bd6e439736374963af05f2afec1ae710e --- /dev/null +++ b/633/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "633", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 28.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/633/surgery_description.txt b/633/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..07eaf82becdabf178959e24c26c97ebed0ebaee7 --- /dev/null +++ b/633/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of Vallecula cancer, Functional bilateral neck dissection, Tracheotomy, PEG placement diff --git a/633/surgery_report.txt b/633/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a4bf78a89c95a004533d21df39e574821db2860 --- /dev/null +++ b/633/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, a pharyngo-laryngoscopy was performed to determine the extent of the tumor. A very superficially growing, slightly exophytic tumor with an uneven mucosal surface was found in the area of the vallecula. The tumor occupies the entire vallecula, passes centrally to the base of the tongue and extends over almost the entire surface of the lingual epiglottis as well as over the right edge of the epiglottis. Now first perform the PEG insertion. To do this, enter with the gastroscope under laryngoscopic control. Pre-insufflation into the stomach without any problems under constant air insufflation. If conditions are normal and diaphanoscopy is good, puncture the stomach and insert the PEG tube using the usual thread pull-through method without any problems. No abnormalities in the area of the esophagus on reflection. Now enter with the Steiner tube and visualize the findings. Successive removal of the very superficially grown tumor with constant correction of the spreading tube. Under the microscope, it can be seen that a tumor cone is also moving across the aryepiglottic fold towards the anterior piriform sinus wall. The superficial tumor is removed in the area of the epiglottis with the mucosa on the cartilage. The free right epiglottis margin and parts of the aryepiglottic fold are removed. This results in a complete resection of the vallecula with partial resection of the base of the tongue and partial resection of the epiglottis. This is followed by a post-resection, which corresponds to the tumor cones in the direction of the piriform sinus anterior wall. Marginal samples are taken in the area of the left vallecula and the base of the tongue. Due to the extensive tumor growth and the sometimes clearly dysplastic mucosal conditions at the tumor extensions, no further marginal samples are taken. Finally, when the wound is dry, the tracheotomy is performed due to the large area of the wound. A T-shaped incision is made below the cricoid. Cut through the subcutaneous tissue. Exposure of the prelaryngeal musculature. Expose the cricoid cartilage and carefully detach the thyroid isthmus, which is very thin here. Pronounced bipolar coagulation and separation of the thyroid isthmus. Exposure of the anterior tracheal wall and insertion between the 2nd and 3rd tracheal ring. Creation of a Björk flap and insertion of the tracheostoma in the usual manner. Now first perform the neck dissection on the left side. To do this, make a skin incision on the anterior edge of the sternocleidomastoid. Cut through the subcutaneous tissue and platysma. Creation of a platysmal flap. Exposure and preservation of the external jugular vein and the auricular nerve. Exposure of the anterior edge of the sternocleidomastoid. Exposure of the muscle. Exposure of the accessorius nerve. Numerous lymph nodes in the area of the venous angle and the accessorius triangle are already visible in the preliminary preparation. Now expose the omohyoid muscle. Trace the muscle and expose up to the hyoid. Expose the submandibular gland, taking the caudal gland capsule with it. Release in the direction of the hyoid. Exposure of the digastric muscle. Exposure of the facial vein. Now expose the cervical vein and in this layer release the anterior neck preparation while carefully preserving and exposing the superior thyroid artery as well as the vein and the hypoglossal nerve. Now free preparation of the vein while carefully protecting the lymph nodes lying on it. Cranial dissection up to the digaster, carefully protecting the accessorius, which runs over the vein and on which numerous nodes lie. In some cases very laborious dissection here, but no macroscopic lymph nodes exceeding the capsule. Clearing of the accessorius triangle and level V coming via the cervical sinus while carefully protecting the plexus branches. If the wound is finally dry, wound irrigation and two-layer wound closure after insertion of a 10 Redon drain. At the same time, perform the neck dissection on the right side. Here too, skin incision at the anterior edge of the sternocleidomastoid. Separation of the platysma. Exposure of the sternocleidomastoid muscle. A large lymph node conglomerate lying on the internal jugular vein can already be seen here. First visualization of the omohyoid muscle. Exposure of the submandibular gland and the digastric nerve. Now successive exposure of the lymph node conglomerate, which lies broadly against the facial vein and the internal jugular vein. Particularly difficult dissection here. The mass is directly adjacent to the vein and can only be separated from it in a final layer with great effort. Meticulous dissection is also required in the area of the nevus accessorius. Here, too, the mass is in direct contact with the vein. However, all the structures mentioned could be preserved. Separation of the mass. Then completion of the neck dissection. Successive clearing of level V with careful protection of the plexus branches. Similarly, complete anteriorly. Clearing out here, also protecting the hypoglossal nerve and the superior thyroid artery. If the wound is finally dry, final inspection and wound irrigation and, after insertion of a 10-gauge Redon drain and two-layer wound closure, completion of the procedure after final reintubation on an 8-gauge low-cuff cannula without any indication of complications. Conclusion: Neck dissection performed on the right side at the same time. Here too, skin incision at the anterior edge of the sternocleidomastoid. Separation of the platysma. Exposure of the sternocleidomastoid muscle. A large lymph node conglomerate lying on the internal jugular vein can already be seen here. First visualization of the omohyoid muscle. Exposure of the submandibular gland and the digastric nerve. Now successive exposure of the lymph node conglomerate, which lies broadly against the facial vein and the internal jugular vein. Particularly difficult dissection here. The mass is directly adjacent to the vein and can only be separated from it with great effort in a final layer meticulous Extensive vallecula carcinoma with cN2c neck status on the right side. Pronounced lymph node conglomerate in the area of the accessorius triangle and the venous angle, which was removed with considerable effort by a functional neck dissection. Due to the very superficial tumor growth and the broad extension as well as the expected further dysplastic mucosal conditions in the head and neck area and the adjuvant therapy that was certainly indicated, the tumor resection was performed without extensive covering of the marginal specimens. Treatment with tracheal cannula depending on postoperative swallowing function. \ No newline at end of file diff --git a/634/InvasionFront_CD3_block10_x5_y9_patient634_0.json b/634/InvasionFront_CD3_block10_x5_y9_patient634_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c0419cafd4318a536a2653ca38d35bba2eb64e3b --- /dev/null +++ b/634/InvasionFront_CD3_block10_x5_y9_patient634_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17470.4, + "Centroid Y µm": 29166.4, + "Num Detections": 20372, + "Num Negative": 17381, + "Num Positive": 2991, + "Positive %": 14.68, + "Num Positive per mm^2": 1189.6 + } +} \ No newline at end of file diff --git a/634/InvasionFront_CD3_block10_x6_y9_patient634_1.json b/634/InvasionFront_CD3_block10_x6_y9_patient634_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32db4dca4f810dba7163c08183072983f0265dc0 --- /dev/null +++ b/634/InvasionFront_CD3_block10_x6_y9_patient634_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19874.2, + "Centroid Y µm": 29479.3, + "Num Detections": 21090, + "Num Negative": 19000, + "Num Positive": 2090, + "Positive %": 9.91, + "Num Positive per mm^2": 850.85 + } +} \ No newline at end of file diff --git a/634/InvasionFront_CD8_block10_x5_y9_patient634_0.json b/634/InvasionFront_CD8_block10_x5_y9_patient634_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b2949e385e531743f8ffca8c83553cb329043d2d --- /dev/null +++ b/634/InvasionFront_CD8_block10_x5_y9_patient634_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17815.6, + "Centroid Y µm": 29159.6, + "Num Detections": 18482, + "Num Negative": 16232, + "Num Positive": 2250, + "Positive %": 12.17, + "Num Positive per mm^2": 928.94 + } +} \ No newline at end of file diff --git a/634/InvasionFront_CD8_block10_x6_y9_patient634_1.json b/634/InvasionFront_CD8_block10_x6_y9_patient634_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3852a365178f87c5968c14871e87a2ff53b3f13b --- /dev/null +++ b/634/InvasionFront_CD8_block10_x6_y9_patient634_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20264.3, + "Centroid Y µm": 29159.6, + "Num Detections": 19281, + "Num Negative": 17752, + "Num Positive": 1529, + "Positive %": 7.93, + "Num Positive per mm^2": 637.5 + } +} \ No newline at end of file diff --git a/634/TumorCenter_CD3_block10_x5_y9_patient634_0.json b/634/TumorCenter_CD3_block10_x5_y9_patient634_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cfae7730bf6758fdf003ebc12ee17e7bb864e951 --- /dev/null +++ b/634/TumorCenter_CD3_block10_x5_y9_patient634_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 22288.2, + "Num Detections": 18758, + "Num Negative": 17528, + "Num Positive": 1230, + "Positive %": 6.557, + "Num Positive per mm^2": 530.24 + } +} \ No newline at end of file diff --git a/634/TumorCenter_CD3_block10_x6_y9_patient634_1.json b/634/TumorCenter_CD3_block10_x6_y9_patient634_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d5e8119a1e0ddad929f717c49ee336306b3d45b0 --- /dev/null +++ b/634/TumorCenter_CD3_block10_x6_y9_patient634_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21388.7, + "Centroid Y µm": 22288.2, + "Num Detections": 17130, + "Num Negative": 16691, + "Num Positive": 439, + "Positive %": 2.563, + "Num Positive per mm^2": 228.93 + } +} \ No newline at end of file diff --git a/634/TumorCenter_CD8_block10_x5_y9_patient634_0.json b/634/TumorCenter_CD8_block10_x5_y9_patient634_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e84f1ddec49654cf155c7049302fc4799ba321df --- /dev/null +++ b/634/TumorCenter_CD8_block10_x5_y9_patient634_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16666.2, + "Centroid Y µm": 22937.9, + "Num Detections": 18877, + "Num Negative": 18064, + "Num Positive": 813, + "Positive %": 4.307, + "Num Positive per mm^2": 357.1 + } +} \ No newline at end of file diff --git a/634/TumorCenter_CD8_block10_x6_y9_patient634_1.json b/634/TumorCenter_CD8_block10_x6_y9_patient634_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8ea8ccde9c24b6447826124fe2b124c55280a5ae --- /dev/null +++ b/634/TumorCenter_CD8_block10_x6_y9_patient634_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 22912.9, + "Num Detections": 16933, + "Num Negative": 16321, + "Num Positive": 612, + "Positive %": 3.614, + "Num Positive per mm^2": 310.47 + } +} \ No newline at end of file diff --git a/634/history_text.txt b/634/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/634/icd_codes.txt b/634/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/634/ops_codes.txt b/634/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/634/patient_clinical_data.json b/634/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2532a7ac684046542aced9e66dbb2af05edd30c8 --- /dev/null +++ b/634/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 46, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/634/patient_pathological_data.json b/634/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6c2d877d4d9c19a853677760ee02eaf0490a209c --- /dev/null +++ b/634/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "634", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/634/surgery_description.txt b/634/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..720ecfa93f6b3e99d31d297705408fcd4385159a --- /dev/null +++ b/634/surgery_description.txt @@ -0,0 +1 @@ +Closure of tracheostomy diff --git a/634/surgery_report.txt b/634/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/635/InvasionFront_CD3_block18_x5_y8_patient635_0.json b/635/InvasionFront_CD3_block18_x5_y8_patient635_0.json new file mode 100644 index 0000000000000000000000000000000000000000..48965945ecddc85b70adcab11b3768904a4e4e52 --- /dev/null +++ b/635/InvasionFront_CD3_block18_x5_y8_patient635_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 25086.7, + "Num Detections": 20530, + "Num Negative": 19919, + "Num Positive": 611, + "Positive %": 2.976, + "Num Positive per mm^2": 256.68 + } +} \ No newline at end of file diff --git a/635/InvasionFront_CD3_block18_x6_y8_patient635_1.json b/635/InvasionFront_CD3_block18_x6_y8_patient635_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7488d3d6de2249d573f6dd66c5282089032e5a0c --- /dev/null +++ b/635/InvasionFront_CD3_block18_x6_y8_patient635_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 25161.7, + "Num Detections": 16862, + "Num Negative": 16671, + "Num Positive": 191, + "Positive %": 1.133, + "Num Positive per mm^2": 110.43 + } +} \ No newline at end of file diff --git a/635/InvasionFront_CD8_block18_x5_y8_patient635_0.json b/635/InvasionFront_CD8_block18_x5_y8_patient635_0.json new file mode 100644 index 0000000000000000000000000000000000000000..16a9df96e1b3ac12aeed8c51b2f5bb3f83632e1a --- /dev/null +++ b/635/InvasionFront_CD8_block18_x5_y8_patient635_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16303.9, + "Centroid Y µm": 27610.4, + "Num Detections": 20678, + "Num Negative": 20473, + "Num Positive": 205, + "Positive %": 0.9914, + "Num Positive per mm^2": 86.33 + } +} \ No newline at end of file diff --git a/635/InvasionFront_CD8_block18_x6_y8_patient635_1.json b/635/InvasionFront_CD8_block18_x6_y8_patient635_1.json new file mode 100644 index 0000000000000000000000000000000000000000..92c47313693544a7a138f302645f689f0ad143da --- /dev/null +++ b/635/InvasionFront_CD8_block18_x6_y8_patient635_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 27510.4, + "Num Detections": 15252, + "Num Negative": 15105, + "Num Positive": 147, + "Positive %": 0.9638, + "Num Positive per mm^2": 87.34 + } +} \ No newline at end of file diff --git a/635/TumorCenter_CD3_block18_x5_y8_patient635_0.json b/635/TumorCenter_CD3_block18_x5_y8_patient635_0.json new file mode 100644 index 0000000000000000000000000000000000000000..defeb5b10b9a82f3f1740da985975dba3fa595e3 --- /dev/null +++ b/635/TumorCenter_CD3_block18_x5_y8_patient635_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15654.2, + "Centroid Y µm": 19502.2, + "Num Detections": 19090, + "Num Negative": 19048, + "Num Positive": 42, + "Positive %": 0.22, + "Num Positive per mm^2": 19.13 + } +} \ No newline at end of file diff --git a/635/TumorCenter_CD3_block18_x6_y8_patient635_1.json b/635/TumorCenter_CD3_block18_x6_y8_patient635_1.json new file mode 100644 index 0000000000000000000000000000000000000000..26cd9c356ef0c5b63d1d7371e494be32a5e8167b --- /dev/null +++ b/635/TumorCenter_CD3_block18_x6_y8_patient635_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18140.4, + "Centroid Y µm": 19552.1, + "Num Detections": 19436, + "Num Negative": 19132, + "Num Positive": 304, + "Positive %": 1.564, + "Num Positive per mm^2": 136.84 + } +} \ No newline at end of file diff --git a/635/TumorCenter_CD8_block18_x5_y8_patient635_0.json b/635/TumorCenter_CD8_block18_x5_y8_patient635_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a7fae8a45ab1a36e32ee452a20117d6d9ebb28fa --- /dev/null +++ b/635/TumorCenter_CD8_block18_x5_y8_patient635_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15716.7, + "Centroid Y µm": 20389.2, + "Num Detections": 19655, + "Num Negative": 19646, + "Num Positive": 9, + "Positive %": 0.0458, + "Num Positive per mm^2": 4.199 + } +} \ No newline at end of file diff --git a/635/TumorCenter_CD8_block18_x6_y8_patient635_1.json b/635/TumorCenter_CD8_block18_x6_y8_patient635_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a41fa46546e73f2515111ca4b67652a48bfcbd3b --- /dev/null +++ b/635/TumorCenter_CD8_block18_x6_y8_patient635_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17915.5, + "Centroid Y µm": 20464.2, + "Num Detections": 17661, + "Num Negative": 17506, + "Num Positive": 155, + "Positive %": 0.8776, + "Num Positive per mm^2": 71.56 + } +} \ No newline at end of file diff --git a/635/history_text.txt b/635/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1df0ab9f47e8ff684ea0749288cfd005bf364090 --- /dev/null +++ b/635/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Histologically confirmed laryngeal carcinoma in the area of the left vocal fold, extending from the tip of the arytenoid cartilage to just below the anterior commissure. \ No newline at end of file diff --git a/635/icd_codes.txt b/635/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/635/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/635/ops_codes.txt b/635/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..349cf7c7607ff28a247e8ea84b89b33f4b830233 --- /dev/null +++ b/635/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] \ No newline at end of file diff --git a/635/patient_clinical_data.json b/635/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5b6ef49125c5ff08de79e101146ac412bc8cff54 --- /dev/null +++ b/635/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/635/patient_pathological_data.json b/635/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8c334c62adf787a84e8a5b478ca7cffd2d749857 --- /dev/null +++ b/635/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "635", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/635/surgery_description.txt b/635/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5462faa1f571443b90f96a41d612b40acfcafecc --- /dev/null +++ b/635/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection diff --git a/635/surgery_report.txt b/635/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..48330c109230ef2aac66235213422f1563e7b802 --- /dev/null +++ b/635/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. Adjustment with the small small water tube. Exposure of the anterior commissure is somewhat difficult, but can be ensured by applying significant external pressure. Incision of the process, which occupies the entire left vocal fold from the arytenoid cartilage to just before the anterior commissure. Resection safely in healthy tissue both in the area of the arytenoid cartilage tip and in the area of the anterior commissure as well as laterally, cranially and caudally. A partial chordectomy is performed. Removal of two marginal samples. Careful hemostasis. Dry conditions at the end of the operation. The tube was covered with a swab before resection. Hemostasis was achieved by coagulation and insertion of suprarenal swabs. Final consultation with the anesthesiologist. Completion of the procedure. With these findings, a control MLE should be performed in approx. 6 - 8 weeks. \ No newline at end of file diff --git a/636/InvasionFront_CD3_block22_x5_y7_patient636_0.json b/636/InvasionFront_CD3_block22_x5_y7_patient636_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7e48fd0ab6a3516d5cb20cf39c55befa2c4d5031 --- /dev/null +++ b/636/InvasionFront_CD3_block22_x5_y7_patient636_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17115.9, + "Centroid Y µm": 29159.6, + "Num Detections": 25350, + "Num Negative": 21714, + "Num Positive": 3636, + "Positive %": 14.34, + "Num Positive per mm^2": 1532.2 + } +} \ No newline at end of file diff --git a/636/InvasionFront_CD3_block22_x6_y7_patient636_1.json b/636/InvasionFront_CD3_block22_x6_y7_patient636_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c0375f325c6c9bc76e47dddfceab7982eb6a7146 --- /dev/null +++ b/636/InvasionFront_CD3_block22_x6_y7_patient636_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19614.6, + "Centroid Y µm": 29259.5, + "Num Detections": 18361, + "Num Negative": 16044, + "Num Positive": 2317, + "Positive %": 12.62, + "Num Positive per mm^2": 1239.0 + } +} \ No newline at end of file diff --git a/636/InvasionFront_CD8_block22_x5_y7_patient636_0.json b/636/InvasionFront_CD8_block22_x5_y7_patient636_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f8e60eef80b50b525b856ab8473d9fd1eedde27 --- /dev/null +++ b/636/InvasionFront_CD8_block22_x5_y7_patient636_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19349.2, + "Centroid Y µm": 17377.5, + "Num Detections": 25323, + "Num Negative": 23408, + "Num Positive": 1915, + "Positive %": 7.562, + "Num Positive per mm^2": 877.65 + } +} \ No newline at end of file diff --git a/636/InvasionFront_CD8_block22_x6_y7_patient636_1.json b/636/InvasionFront_CD8_block22_x6_y7_patient636_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fa17ef4eefd2dbffba229de426dc04a638950be5 --- /dev/null +++ b/636/InvasionFront_CD8_block22_x6_y7_patient636_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21928.0, + "Centroid Y µm": 17225.0, + "Num Detections": 17844, + "Num Negative": 17119, + "Num Positive": 725, + "Positive %": 4.063, + "Num Positive per mm^2": 382.61 + } +} \ No newline at end of file diff --git a/636/TumorCenter_CD3_block22_x5_y7_patient636_0.json b/636/TumorCenter_CD3_block22_x5_y7_patient636_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8a2c24ba3fd96254987e65e9dd97cffd9155d48f --- /dev/null +++ b/636/TumorCenter_CD3_block22_x5_y7_patient636_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16616.2, + "Centroid Y µm": 18140.4, + "Num Detections": 14945, + "Num Negative": 14371, + "Num Positive": 574, + "Positive %": 3.841, + "Num Positive per mm^2": 352.88 + } +} \ No newline at end of file diff --git a/636/TumorCenter_CD3_block22_x6_y7_patient636_1.json b/636/TumorCenter_CD3_block22_x6_y7_patient636_1.json new file mode 100644 index 0000000000000000000000000000000000000000..05c2b88b5cb1eb2bad99300636604700298d2bfc --- /dev/null +++ b/636/TumorCenter_CD3_block22_x6_y7_patient636_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19189.8, + "Centroid Y µm": 18265.3, + "Num Detections": 26355, + "Num Negative": 24968, + "Num Positive": 1387, + "Positive %": 5.263, + "Num Positive per mm^2": 518.22 + } +} \ No newline at end of file diff --git a/636/TumorCenter_CD8_block22_x5_y7_patient636_0.json b/636/TumorCenter_CD8_block22_x5_y7_patient636_0.json new file mode 100644 index 0000000000000000000000000000000000000000..df770b36d562f37cbb541c74bda79f364b8e80db --- /dev/null +++ b/636/TumorCenter_CD8_block22_x5_y7_patient636_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 27635.4, + "Num Detections": 13662, + "Num Negative": 12925, + "Num Positive": 737, + "Positive %": 5.395, + "Num Positive per mm^2": 492.66 + } +} \ No newline at end of file diff --git a/636/TumorCenter_CD8_block22_x6_y7_patient636_1.json b/636/TumorCenter_CD8_block22_x6_y7_patient636_1.json new file mode 100644 index 0000000000000000000000000000000000000000..27e9c81bc83fdaae867577738fb1783c9780086e --- /dev/null +++ b/636/TumorCenter_CD8_block22_x6_y7_patient636_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21463.6, + "Centroid Y µm": 27710.3, + "Num Detections": 26521, + "Num Negative": 25384, + "Num Positive": 1137, + "Positive %": 4.287, + "Num Positive per mm^2": 432.83 + } +} \ No newline at end of file diff --git a/636/history_text.txt b/636/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..75212411a6968c0b1bfc7eef4ec0666c721748c5 --- /dev/null +++ b/636/history_text.txt @@ -0,0 +1 @@ +A right cervical squamous cell carcinoma metastasis was histologically confirmed externally in the patient. With an initial suspected diagnosis of CUP syndrome, a cT1 hypopharyngeal carcinoma was histologically confirmed as the primary tumor during a panendoscopy. In addition to unclear esophageal changes, clarification by our colleagues in Medicine 1 revealed a CIS 24 cm from the tooth row with additional unclear lung findings. In our interdisciplinary tumor conference, it was decided that the primary surgical treatment of the hypopharyngeal carcinoma would be re-evaluation and, if necessary, endoscopic resection of the esophageal findings and monitoring of the lung findings. \ No newline at end of file diff --git a/636/icd_codes.txt b/636/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b7a3aa48a2b4f72d0427531982df8a87d46a07e6 --- /dev/null +++ b/636/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hinterwand des Hypopharynx[C13.2 ] Sekundäre und nicht näher bezeichnete bösartige Neubildung: Lymphknoten des Kopfes, des Gesichtes und des Halses[C77.0 ] \ No newline at end of file diff --git a/636/ops_codes.txt b/636/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..087370d32832d79da2c997823c265a112eae135a --- /dev/null +++ b/636/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion von erkranktem Gewebe des Pharynx: Destruktion: Elektrokoagulation[5-292.30 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal: 5 Regionen[5-403.11 B] Radikale Resektion des Pharynx [Pharyngektomie]: Transoral: Rekonstruktion mit lokaler Schleimhaut[5-296.01 ] \ No newline at end of file diff --git a/636/patient_clinical_data.json b/636/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6f92732f464ce7ab532de098839f9fc7b75eb642 --- /dev/null +++ b/636/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/636/patient_pathological_data.json b/636/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1e924ed544b090dcd5fe51e3a72c6d16b3a08483 --- /dev/null +++ b/636/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "636", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 22, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/636/surgery_description.txt b/636/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4bd6bce41762e7962fe5cba5beabaee07c3e471e --- /dev/null +++ b/636/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection (TORS), Bilateral neck dissection diff --git a/636/surgery_report.txt b/636/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d64576c1944bc5271275575e2ad2013a985a5c01 --- /dev/null +++ b/636/surgery_report.txt @@ -0,0 +1 @@ +After induction and intubation by the anesthesia colleagues, the patient is first positioned. Repeat pharyngo-/laryngoscopy: For this purpose, enter with the Kleinsasser tube under dental protection. With an unremarkable oral cavity and oropharynx as well as an unremarkable endolarynx, the exophytic tumor can be seen in the right-sided postcricoid region, as described above, measuring approx. 2 cm and still well mobile at the mucosal level without submucosal infiltration of the thyroid cartilage or the arytenoid joints. The rest of the hypopharynx is free up to the tips of the piriform sinus and the esophageal opening. The dental guard, the lip retractor and the FK blocker are now inserted. Difficult, but ultimately regular adjustability of the tumor with good exposure of the postcricoid region. Successive resection of the tumor with the monopolar. Resection while sparing the cartilaginous bony structure. The tumor is sent for definitive histology. Removal of representative marginal samples. These are shown to be completely tumor-free in the frozen section diagnostics. Therefore, after careful wound inspection and hemostasis, a nasogastric feeding tube is initially inserted if the endolaryngeal conditions are narrow and a tracheotomy is not performed if the conditions are narrow. Rearrangement for neck dissection: palpation reveals a rough and barely displaceable paralaryngeal mass. Injection of xylocaine with adrenaline. Incision of the old scar. Cutting of skin and subcutaneous tissue. Subcutaneous extensive scarring. Cutting through the remains of the platysma. Exposure of the sternocleidomastoid muscle. This is broadly infiltrated from the underside, therefore first exposing the submandibular gland and the digastric muscle. Exposure of the omohyoid muscle caudally. Separation of the sternocleidomastoid muscle and preservation of the external jugular vein. The omohyoid muscle is also clearly infiltrated. The same applies to the parlaryngeal musculature. The cranial accessorius nerve can be preserved. Thorough exposure of the internal jugular vein. The facial vein is infiltrated, otherwise the internal jugular vein can be preserved. Careful dissection of the common carotid artery. The mass extends directly to the perivascular connective tissue, but is certainly not infiltrated. Dissection in case of infiltration of the superior thyroid artery. There is also clear infiltration of the hypoglossal nerve. This is also removed. Dissection of the cervical vascular sheath, which is normal except for the infiltration of the structures mentioned. Clearing of the accessorius triangle while preserving the nerve. Clearing of level V with careful preservation of the cervical plexus branches. Overall en bloc resection of the massively surrounding scarred and massively perinodally growing metastasis. Careful wound inspection. Wound irrigation. Insertion of a 10-gauge Redon drain and careful two-layer wound closure. Turning to the opposite side: skin incision also made on the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Removal of the anterior neck preparation with careful protection of the superior thyroid artery, the facial vein and the cervical vein. Free preparation of the internal jugular vein. Exposure of the accessorius nerve. Clearing of the accessorius triangle and clearing of level V a with careful protection of the cervical plexus branches. Careful wound inspection and, if the wound is dry, wound irrigation, insertion of a 10 Redon drain and careful two-layer wound closure. Subsequent completion of the procedure with slim enoral conditions. The patient received intraoperative single-shot antibiotics with Unacid. Postoperative nutrition via the inserted nasogastric tube for 3 to 4 days, after which oral nutrition should be possible without any problems. Presentation in our interdisciplinary tumor conference and in the meantime planning of a new esophagogastroscopy with endosonography as already indicated by our colleagues in internal medicine. \ No newline at end of file diff --git a/637/InvasionFront_CD3_block4_x3_y8_patient637_0.json b/637/InvasionFront_CD3_block4_x3_y8_patient637_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7f63137637b5958a3365b05d16922b76ae4039a1 --- /dev/null +++ b/637/InvasionFront_CD3_block4_x3_y8_patient637_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 26111.2, + "Num Detections": 19470, + "Num Negative": 17770, + "Num Positive": 1700, + "Positive %": 8.731, + "Num Positive per mm^2": 733.16 + } +} \ No newline at end of file diff --git a/637/InvasionFront_CD3_block4_x4_y8_patient637_1.json b/637/InvasionFront_CD3_block4_x4_y8_patient637_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b422042dc9157ef5602d405a2e36bc2a7bcacb9f --- /dev/null +++ b/637/InvasionFront_CD3_block4_x4_y8_patient637_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 26286.1, + "Num Detections": 17561, + "Num Negative": 15547, + "Num Positive": 2014, + "Positive %": 11.47, + "Num Positive per mm^2": 1026.8 + } +} \ No newline at end of file diff --git a/637/InvasionFront_CD8_block4_x3_y8_patient637_0.json b/637/InvasionFront_CD8_block4_x3_y8_patient637_0.json new file mode 100644 index 0000000000000000000000000000000000000000..36ebc7f8a82f67f749dbb128488ede3fada5cb38 --- /dev/null +++ b/637/InvasionFront_CD8_block4_x3_y8_patient637_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 24911.8, + "Num Detections": 17080, + "Num Negative": 15455, + "Num Positive": 1625, + "Positive %": 9.514, + "Num Positive per mm^2": 687.51 + } +} \ No newline at end of file diff --git a/637/InvasionFront_CD8_block4_x4_y8_patient637_1.json b/637/InvasionFront_CD8_block4_x4_y8_patient637_1.json new file mode 100644 index 0000000000000000000000000000000000000000..842c8573c78de2ce862b92b481d80513eb3823f2 --- /dev/null +++ b/637/InvasionFront_CD8_block4_x4_y8_patient637_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 24961.8, + "Num Detections": 20840, + "Num Negative": 18413, + "Num Positive": 2427, + "Positive %": 11.65, + "Num Positive per mm^2": 970.41 + } +} \ No newline at end of file diff --git a/637/TumorCenter_CD3_block4_x3_y8_patient637_0.json b/637/TumorCenter_CD3_block4_x3_y8_patient637_0.json new file mode 100644 index 0000000000000000000000000000000000000000..318b34c098586f326b0fd5d96c541978ad5b4d15 --- /dev/null +++ b/637/TumorCenter_CD3_block4_x3_y8_patient637_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 20564.1, + "Num Detections": 15372, + "Num Negative": 14958, + "Num Positive": 414, + "Positive %": 2.693, + "Num Positive per mm^2": 198.25 + } +} \ No newline at end of file diff --git a/637/TumorCenter_CD3_block4_x4_y8_patient637_1.json b/637/TumorCenter_CD3_block4_x4_y8_patient637_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd58c644c05f1de3cbfca8da73147144926a4084 --- /dev/null +++ b/637/TumorCenter_CD3_block4_x4_y8_patient637_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 20589.1, + "Num Detections": 16986, + "Num Negative": 15911, + "Num Positive": 1075, + "Positive %": 6.329, + "Num Positive per mm^2": 473.22 + } +} \ No newline at end of file diff --git a/637/TumorCenter_CD8_block4_x3_y8_patient637_0.json b/637/TumorCenter_CD8_block4_x3_y8_patient637_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ca8bf322f991efb77d0320b7131401174d4c0963 --- /dev/null +++ b/637/TumorCenter_CD8_block4_x3_y8_patient637_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11319.0, + "Centroid Y µm": 20364.2, + "Num Detections": 17396, + "Num Negative": 16908, + "Num Positive": 488, + "Positive %": 2.805, + "Num Positive per mm^2": 226.05 + } +} \ No newline at end of file diff --git a/637/TumorCenter_CD8_block4_x4_y8_patient637_1.json b/637/TumorCenter_CD8_block4_x4_y8_patient637_1.json new file mode 100644 index 0000000000000000000000000000000000000000..77ddf7d5dcec446300ba5a2d0b369e8567301687 --- /dev/null +++ b/637/TumorCenter_CD8_block4_x4_y8_patient637_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 20564.1, + "Num Detections": 16481, + "Num Negative": 15590, + "Num Positive": 891, + "Positive %": 5.406, + "Num Positive per mm^2": 391.79 + } +} \ No newline at end of file diff --git a/637/history_text.txt b/637/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1dbfaa041b662f433b13a8d152f878a553f85316 --- /dev/null +++ b/637/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the vallecula/base of tongue area. Therefore, the above-mentioned surgery was indicated. \ No newline at end of file diff --git a/637/icd_codes.txt b/637/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e4ca761b56eac528a4c45515908230daac30da7 --- /dev/null +++ b/637/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] Supraglottisches Karzinom[C32.1 R] \ No newline at end of file diff --git a/637/ops_codes.txt b/637/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..70d1624d65dd02ff3093adb8ace77238a381628b --- /dev/null +++ b/637/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme eines freien Lappens am Unterarm mit mikrovaskulärer Anastomosierung[5-904.08 L] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Exzision Epiglottis[5-302.y ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/637/patient_clinical_data.json b/637/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2aeb0c5d34abbe267f203a108d070e8afb341297 --- /dev/null +++ b/637/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/637/patient_pathological_data.json b/637/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3c1f286cda914769433b719489e7c0305b6eab9f --- /dev/null +++ b/637/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "637", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/637/surgery_description.txt b/637/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/637/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/637/surgery_report.txt b/637/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8974ced05f46a92ec5723bbdc8ff69c0d4ad73e1 --- /dev/null +++ b/637/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again: The exophytic tumor is seen in the area of the lingual epiglottis, vallecula and base of the tongue, extending from the paramedian left to the right, with deep ulceration in the direction of the hyoid bone. There is also a second tumor in the area of the pharyngeal wall on the right at a distance of 1-2 cm. Aryepiglottic fold free on both sides. In the CT, the tumor extends to the hyoid bone. Therefore, laser resection does not make sense, so the primary indication is a transcervical procedure with flap coverage. This is followed by PEG placement: insertion of the flexible esophagoscope into the stomach. Once the diaphanoscopy has been performed, a 15 mm stomach wall tube is inserted without complications. This is also fixed to the abdominal wall in the typical manner. Subsequent repositioning for tumor resection, neck dissection on both sides and flap coverage. Injection of a total of 15 ml Ultracaine with adrenaline into the sides of the neck for the planned apron incision. Sterile draping of all relevant surgical areas. First, creation of an apron incision and lifting of the skin in the sense of an apron flap subplatysmal in a typical manner up to the level above the hyoid bone and at the level of the submandibular gland on both sides. First neck dissection on the right: visualization of the sternocleidomastoid muscle, omohyoid muscle and digastric muscle. Exposure of the internal jugular vein and facial vein. Exposure of the external jugular vein. V. facialis is set off cranially at the gland. This is connected to the relatively narrow internal jugular vein by a dense venous plexus. Exposure of the vagus nerve, hypoglossal nerve and accessorius nerve. Subsequent evacuation of neck level II-V with visualization and preservation of the branches of the cervical plexus. Several enlarged and suspicious lymph nodes, particularly cranially. Subsequent neck dissection on the left by : Drawing of the skin incision in the sense of an apron flap. Skin incision, transection of the cutaneous and subcutaneous tissue and the platysma. Creation of a platysmal flap by subplatysmal dissection of the flap cranially. This is done until the submandibular glandulae are exposed. First turn to the left side. Exposure of the anterior border of the sternocleidomastoid muscle and dissection along the muscle in depth until the branches of the cervical plexus are exposed. Identification of the omohyoid muscle and dissection on the muscle up to the hyoid bone. Identification of the submandibular gland and opening of the glandular capsule as well as release of the gland and dissection anteriorly up to the hyoid bone. Identification of the digasatric muscle. Identification of the N. accessorius and sparing of the free preparation of the nerve. Division of the neck dissection on the internal jugular vein with the blunt dissecting scissors. Now carefully detach the lateral neck preparation Level II, III and IV as well as V in one piece. This is carried out with constant bipolar coagulation of minor bleeding and protection of the surrounding nerve structures. Identification of the hypoglossal nerve and now also release of the medial part of levels II and III. Tracheostoma creation (dictation is still missing) Then combined transoral, transcervical tumor resection: once again visualization and securing of the following structures with the vessel loop N. hypoglossus, A. carotis interna and externa and A. lingualis. Exposure and preservation of the superior laryngeal nerve. Exposure of the pharyngeal wall and separation of this from the area of the vascular sheath and the spinal column. The digastric and stylohyoid muscles are each cut for a better overview. The submandibular gland is removed. Exposure and preservation of the lingual nerve. The Mc Ivor blade is then inserted. The 2nd tumor is exposed transorally and the pharyngeal tube is opened above it under internal and external control. Successive development of the tumor. The entire hyoid bone with attached residual parts of the infrahyoid and suprahyoid musculature is removed. Removal of the supraglottic region including the epiglottis up to the upper edge of the thyroid cartilage with the uppermost parts of the aryepiglottic fold. The lower part of the base of the tongue is resected almost to the opposite side. The lingual nerve from the opposite side is not touched. Vallecula with attached pre-epiglottic fatty tissue and hyoid bone is completely resected. Resection extends cranially to the lower tonsil pole in the area of the pharyngeal wall on the right. Subsequent suture marking of the specimen. Removal of a marginal sample from the base of the tongue. Preparation as a whole in healthy tissue, including marginal sample from the base of the tongue. In the area of the pharyngeal wall in the area of the second tumor, there is still moderate dysplasia up to the edge. Mucosa is therefore removed again in the area mentioned in a width of approx. 5 mm. This is sent for final assessment. This is followed by careful hemostasis and irrigation. Lifting of the radialis graft by : Marking of the graft to be lifted in the presence of . S-shaped skin incision on the proximal forearm and visualization of the venous confluence in the crook of the elbow. A strongly developed cephalic vein can be seen which can be followed distally to the radial edge of the flap. Skin incision in the area of the radial edge of the flap and dissection down to the forearm fascia. This exposes the external ramus of the radial nerve, which can be safely spared. Now also ulnar skin incision and dissection down to the deep forearm fascia. Subfascial dissection, leaving the peritendineum intact and folding the flap over to the border of the extensor carpi radialis muscle. Identification of the flap pedicle and trial clamping using a vascular clamp for 5 minutes: during this time, a good perfusion signal should be measured pulsoxymetrically. Then clamp the distal radial artery with the accompanying veins and place two vascular ligatures using a prolene thread. Successive dissection of the flap pedicle from the depth with constant supply of the perforator vessels using a vessel clip and bipolar coagulation. Dissection of the flap pedicle up to the antecubital fossa, identification of the venous vessels and the outlet of the radial artery. Separation of the radial artery and placement of a vascular ligature. The veins are now also removed and the radial artery graft is lifted without complications. The wound is closed using split skin from the right thigh by and . Then removal of split skin from the right thigh in a typical manner. Closure of the forearm wound and insertion of the split skin into the skin defect. Application of Mepilex dressing and swab dressing, which is molded with absorbent cotton. Arm is fixed in Cramer splint with elastic bandage in functional position. Attachment of the arm. Radialis flap, which was rinsed with heparin after removal, is now inserted into the defect. Successive suturing of the radialis flap into the defect. This is achieved completely tension-free with complete coverage of all relevant defect areas. Radialis is fixed anteriorly to the thyroid cartilage and cranially on the right to the lower tonsil pole. Due to the remaining lack of volume, a Remmert flap is lifted on both sides in the typical manner on the superior thyroid artery and supplied with the cervical artery. Mobilization is carried out to such an extent that the flap can be inserted as a volume substitute without any problems, onto the radial artery flap. Vascular anastomosis beforehand: conditioning of the right lingual artery and the radial artery. Suturing with 9-0 Ethilon single-button sutures. After opening the clamp, good arterial flow, good venous return. Subsequent conditioning of both cephalic veins and the confluent vein. The confluent vein is anastomosed with an outlet from the vascular network of the facial vein, which is connected to both the external and internal jugular vein, using a 2.5 mm coupler after appropriate vascular conditioning. Good venous return after opening the clamps. Positive smear phenomenon. One of the cephalic veins is anastomosed with another outlet from the facial vein using a 2.5 mm coupler. Here too, after opening the clamps, venous flow is good, smear phenomenon positive. All other outlets are clipped both in the area of the flap pedicle and in the area of the facial vein. Subsequent careful irrigation. Hemostasis. Now insertion of the Remmert flap pedicled on both sides into the volume defect. Fixation using several Vicryl sutures both on the mandible and on the upper edge of the thyroid cartilage. Inspection of the flap enoal, which shows good blood circulation. Extensive irrigation again. Hemostasis. Layered wound closure now with epithelialization of the tracheostoma and insertion of a Redondra ring on the left and insertion of 3 flaps on the right. Insertion of a size 8 tracheostomy tube and suture fixation. Completion of the procedure without complications. Patient admitted to the intensive care unit for postoperative monitoring. Please continue antibiotics, which were started intraoperatively, with Unacid for one week. Nutrition via the inserted PEG for 10 days, then gruel swallowing and start with swallowing training if prolonged dysphagia is expected. Flap control for 5 days in a typical manner using Doppler sonography or clinically. Continue heparin perfusor 500 E/h for 5 days. Total cT4 vallecula/base of tongue carcinoma with secondary carcinoma in the area of the right pharyngeal side wall. V.a. cN2c status. Please present postoperatively at the interdisciplinary tumor conference to plan further adjuvant therapy. \ No newline at end of file diff --git a/638/InvasionFront_CD3_block16_x3_y2_patient638_0.json b/638/InvasionFront_CD3_block16_x3_y2_patient638_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e532074a677ec0f446a9860544ae353916c63e29 --- /dev/null +++ b/638/InvasionFront_CD3_block16_x3_y2_patient638_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11802.8, + "Centroid Y µm": 9539.4, + "Num Detections": 14021, + "Num Negative": 13619, + "Num Positive": 402, + "Positive %": 2.867, + "Num Positive per mm^2": 195.57 + } +} \ No newline at end of file diff --git a/638/InvasionFront_CD3_block16_x4_y2_patient638_1.json b/638/InvasionFront_CD3_block16_x4_y2_patient638_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6e1377260a142af6ad7aa2a771264352ee9cf616 --- /dev/null +++ b/638/InvasionFront_CD3_block16_x4_y2_patient638_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14393.3, + "Centroid Y µm": 9502.8, + "Num Detections": 14596, + "Num Negative": 14239, + "Num Positive": 357, + "Positive %": 2.446, + "Num Positive per mm^2": 173.09 + } +} \ No newline at end of file diff --git a/638/InvasionFront_CD8_block16_x3_y2_patient638_0.json b/638/InvasionFront_CD8_block16_x3_y2_patient638_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c5ba149fb176da7f3222e0e7bfde6663dce0a6a --- /dev/null +++ b/638/InvasionFront_CD8_block16_x3_y2_patient638_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11196.4, + "Centroid Y µm": 4998.5, + "Num Detections": 16866, + "Num Negative": 16580, + "Num Positive": 286, + "Positive %": 1.696, + "Num Positive per mm^2": 134.86 + } +} \ No newline at end of file diff --git a/638/InvasionFront_CD8_block16_x4_y2_patient638_1.json b/638/InvasionFront_CD8_block16_x4_y2_patient638_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f930ef6db6dde40f0064d6d70376d48e655d3ee --- /dev/null +++ b/638/InvasionFront_CD8_block16_x4_y2_patient638_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13737.0, + "Centroid Y µm": 5210.6, + "Num Detections": 16547, + "Num Negative": 16306, + "Num Positive": 241, + "Positive %": 1.456, + "Num Positive per mm^2": 120.94 + } +} \ No newline at end of file diff --git a/638/TumorCenter_CD3_block16_x3_y2_patient638_0.json b/638/TumorCenter_CD3_block16_x3_y2_patient638_0.json new file mode 100644 index 0000000000000000000000000000000000000000..537487f808fa879cf2f31eb819c12947cab48188 --- /dev/null +++ b/638/TumorCenter_CD3_block16_x3_y2_patient638_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12443.4, + "Centroid Y µm": 5147.3, + "Num Detections": 14761, + "Num Negative": 14412, + "Num Positive": 349, + "Positive %": 2.364, + "Num Positive per mm^2": 157.73 + } +} \ No newline at end of file diff --git a/638/TumorCenter_CD3_block16_x4_y2_patient638_1.json b/638/TumorCenter_CD3_block16_x4_y2_patient638_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f8d291928ee6bd70001a1b20c8daadbeb883186e --- /dev/null +++ b/638/TumorCenter_CD3_block16_x4_y2_patient638_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15017.0, + "Centroid Y µm": 5322.2, + "Num Detections": 12429, + "Num Negative": 11526, + "Num Positive": 903, + "Positive %": 7.265, + "Num Positive per mm^2": 480.03 + } +} \ No newline at end of file diff --git a/638/TumorCenter_CD8_block16_x3_y2_patient638_0.json b/638/TumorCenter_CD8_block16_x3_y2_patient638_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f76702087989907e65c24fef7f2c9950bbb84075 --- /dev/null +++ b/638/TumorCenter_CD8_block16_x3_y2_patient638_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 5197.2, + "Num Detections": 17481, + "Num Negative": 17436, + "Num Positive": 45, + "Positive %": 0.2574, + "Num Positive per mm^2": 20.33 + } +} \ No newline at end of file diff --git a/638/TumorCenter_CD8_block16_x4_y2_patient638_1.json b/638/TumorCenter_CD8_block16_x4_y2_patient638_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c5b917c3486927ed777fe77e8703055c841447f5 --- /dev/null +++ b/638/TumorCenter_CD8_block16_x4_y2_patient638_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 5222.2, + "Num Detections": 18775, + "Num Negative": 18663, + "Num Positive": 112, + "Positive %": 0.5965, + "Num Positive per mm^2": 49.29 + } +} \ No newline at end of file diff --git a/638/history_text.txt b/638/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f7698ae858cccfccfe69dfe0f26810614a59ccad --- /dev/null +++ b/638/history_text.txt @@ -0,0 +1 @@ +In Mrs. a cT2 cN0 tongue margin carcinoma on the right was histologically confirmed <2013> (poorly differentiated, G3). There is now an indication for transoral laser resection and neck dissection on the right. As the patient categorically rejected neck dissection, only transoral resection of the above-mentioned tumor was discussed with the patient. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/638/icd_codes.txt b/638/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f72acf1463cff8faa68d0fe7b923862418e5d992 --- /dev/null +++ b/638/icd_codes.txt @@ -0,0 +1 @@ +Plattenepithelkarzinom Zungenrand[C02.1 ] \ No newline at end of file diff --git a/638/ops_codes.txt b/638/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0109ff32fcf2862bafdec5f7cb7cac3de30212c3 --- /dev/null +++ b/638/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/638/patient_clinical_data.json b/638/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a3435d5add5883eafb024501a8bd82693c4c2dd8 --- /dev/null +++ b/638/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 80, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/638/patient_pathological_data.json b/638/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5380612df52de05c32b69572bf8d1f91c7c23011 --- /dev/null +++ b/638/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "638", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.7", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/638/surgery_description.txt b/638/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ff419eefe7fd8adf55ca5be53e0ca2c0c846080 --- /dev/null +++ b/638/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy: Transoral: Other diff --git a/638/surgery_report.txt b/638/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0e98801503ee1b646f10435e3b02580cc0d19ba6 --- /dev/null +++ b/638/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is taken to the operating theater. Introductory consultation with the anesthesia department. Carrying out the team time-out. Induction of anesthesia by the anesthesia colleagues. Positioning of the patient by the surgeon. Insertion of the reinforced mouth retractor and looping of the tip of the tongue. Palpatory identification of the tumor borders in the area of the right-lateral, posterior third of the tongue. Marking of the resection margins using the monopolar needle. Successive resection of the tumor while maintaining a sufficient safety distance. Punctual hemostasis is repeatedly performed in between. Resection of the tumor in toto and suture marking. Repeated hemostasis using bipolar coagulation. If the macroscopic safety margin is sufficient, definitive margin samples are deliberately not taken. If the wound bed is dry, the operation is now completed without complications. Remove the tongue suture and the reinforced mouth guard. Final consultation with the anesthetist. Postoperatively, please attend the interdisciplinary tumor conference after receiving the definitive histology. If rejection of the necessary adjuvant therapy is expected, a clear recommendation should be made to the patient. \ No newline at end of file diff --git a/639/InvasionFront_CD3_block22_x1_y2_patient639_0.json b/639/InvasionFront_CD3_block22_x1_y2_patient639_0.json new file mode 100644 index 0000000000000000000000000000000000000000..21b02e9cd902a6cd66d89265a8ed40d01438578c --- /dev/null +++ b/639/InvasionFront_CD3_block22_x1_y2_patient639_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4872.4, + "Centroid Y µm": 16366.3, + "Num Detections": 17673, + "Num Negative": 15492, + "Num Positive": 2181, + "Positive %": 12.34, + "Num Positive per mm^2": 1138.3 + } +} \ No newline at end of file diff --git a/639/InvasionFront_CD3_block22_x2_y2_patient639_1.json b/639/InvasionFront_CD3_block22_x2_y2_patient639_1.json new file mode 100644 index 0000000000000000000000000000000000000000..554cac42e40aa34fa79b424ebaf1f9224eff7b80 --- /dev/null +++ b/639/InvasionFront_CD3_block22_x2_y2_patient639_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7446.1, + "Centroid Y µm": 16491.3, + "Num Detections": 15616, + "Num Negative": 14660, + "Num Positive": 956, + "Positive %": 6.122, + "Num Positive per mm^2": 516.79 + } +} \ No newline at end of file diff --git a/639/InvasionFront_CD8_block22_x1_y2_patient639_0.json b/639/InvasionFront_CD8_block22_x1_y2_patient639_0.json new file mode 100644 index 0000000000000000000000000000000000000000..973f1c6e38d4db9be5e3a052a458fb1795141aef --- /dev/null +++ b/639/InvasionFront_CD8_block22_x1_y2_patient639_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 5796.9, + "Num Detections": 18764, + "Num Negative": 15595, + "Num Positive": 3169, + "Positive %": 16.89, + "Num Positive per mm^2": 1472.4 + } +} \ No newline at end of file diff --git a/639/InvasionFront_CD8_block22_x2_y2_patient639_1.json b/639/InvasionFront_CD8_block22_x2_y2_patient639_1.json new file mode 100644 index 0000000000000000000000000000000000000000..da730029ac6fefbe5b49fddfc59b313890c5ebcd --- /dev/null +++ b/639/InvasionFront_CD8_block22_x2_y2_patient639_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9170.1, + "Centroid Y µm": 5697.0, + "Num Detections": 18244, + "Num Negative": 17924, + "Num Positive": 320, + "Positive %": 1.754, + "Num Positive per mm^2": 142.88 + } +} \ No newline at end of file diff --git a/639/TumorCenter_CD3_block22_x1_y2_patient639_0.json b/639/TumorCenter_CD3_block22_x1_y2_patient639_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ae53cd79664b536bc98d92ea0cd9d453c9e9cfc --- /dev/null +++ b/639/TumorCenter_CD3_block22_x1_y2_patient639_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4797.5, + "Centroid Y µm": 6071.8, + "Num Detections": 16951, + "Num Negative": 16708, + "Num Positive": 243, + "Positive %": 1.434, + "Num Positive per mm^2": 104.86 + } +} \ No newline at end of file diff --git a/639/TumorCenter_CD3_block22_x2_y2_patient639_1.json b/639/TumorCenter_CD3_block22_x2_y2_patient639_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2622befcd23b5149cfa03d44f48c824eb55bc31 --- /dev/null +++ b/639/TumorCenter_CD3_block22_x2_y2_patient639_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7171.2, + "Centroid Y µm": 6046.8, + "Num Detections": 19823, + "Num Negative": 19111, + "Num Positive": 712, + "Positive %": 3.592, + "Num Positive per mm^2": 300.09 + } +} \ No newline at end of file diff --git a/639/TumorCenter_CD8_block22_x1_y2_patient639_0.json b/639/TumorCenter_CD8_block22_x1_y2_patient639_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e69bb4e4c68772a0a9cbfbbf3594309e3e758f09 --- /dev/null +++ b/639/TumorCenter_CD8_block22_x1_y2_patient639_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7071.3, + "Centroid Y µm": 14717.2, + "Num Detections": 17163, + "Num Negative": 16551, + "Num Positive": 612, + "Positive %": 3.566, + "Num Positive per mm^2": 264.04 + } +} \ No newline at end of file diff --git a/639/TumorCenter_CD8_block22_x2_y2_patient639_1.json b/639/TumorCenter_CD8_block22_x2_y2_patient639_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a99f6d97007d208e5c2887b39682ac7f8a17c350 --- /dev/null +++ b/639/TumorCenter_CD8_block22_x2_y2_patient639_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9470.0, + "Centroid Y µm": 14842.1, + "Num Detections": 19637, + "Num Negative": 18731, + "Num Positive": 906, + "Positive %": 4.614, + "Num Positive per mm^2": 380.0 + } +} \ No newline at end of file diff --git a/639/history_text.txt b/639/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c238261dde4a40b04806c0a55df0949e4344eadd --- /dev/null +++ b/639/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: A control MLE revealed carcinoma in situ in the area of the right anterior larynx following partial laryngectomy in 2008, indicating a new surgical procedure. \ No newline at end of file diff --git a/639/icd_codes.txt b/639/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/639/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/639/ops_codes.txt b/639/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8a2ac1de86c4ce7067ebba0b2de0a5b5d3f60011 --- /dev/null +++ b/639/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, endolaryngeal[5-300.0 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] \ No newline at end of file diff --git a/639/patient_clinical_data.json b/639/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0880eceffb451a21d61b45aefaaef00fd82eebe7 --- /dev/null +++ b/639/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/639/patient_pathological_data.json b/639/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..db3d153b80be844785d93a3f19454d41ffcbef95 --- /dev/null +++ b/639/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "639", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/639/surgery_description.txt b/639/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d35f1334448df86cb7ad3d299d980d7bd43280aa --- /dev/null +++ b/639/surgery_description.txt @@ -0,0 +1 @@ +Resection of laryngeal cancer diff --git a/639/surgery_report.txt b/639/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..88f9206372165a12efae17e5e0103a1b56f57c16 --- /dev/null +++ b/639/surgery_report.txt @@ -0,0 +1 @@ +Initial consultation with the anesthesiologist. Intubation of the patient by the anesthetist, which is very difficult due to the anatomical situation. Adjustment with the size C small bore tube. There are granulating changes in the area of the larynx due to nicotine abuse and surgery. A definite tumor is no longer recognizable after the tumor was already subtotally removed during the first operation approx. 6 weeks ago. In the area of the former tumor region, in the area of the glottis on the right front, a resection was performed. Careful hemostasis. The surgical procedure is significantly hindered by the patient's very difficult positioning. The patient is alternated between a small bore tube and a size D tube. As far as can be assessed intraoperatively, no tumor can now be detected. A marginal sample is taken from the left anterior region. Extremely difficult procedure. No further measures due to the current situation. Finally, endoscopy of the cervical trachea, glottis, subglottis and supraglottis. No evidence of tumor manifestation on all sides, but overall clearly altered mucosal conditions. Wait for the marginal sample and repeat control microlaryngoendoscopy in approx. 6-8 weeks. No further measures should be taken in view of the patient's overall situation with a very narrow larynx and the risk of edema formation. Final consultation with the anesthesia department. The risk of postoperative edema formation is discussed here in particular. Note: Extremely difficult surgical procedure due to the previous operation and the patient's overall situation and in view of the local findings. \ No newline at end of file diff --git a/640/InvasionFront_CD3_block19_x1_y5_patient640_0.json b/640/InvasionFront_CD3_block19_x1_y5_patient640_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad7a93ed4c560842961daec7e1c9ce5393ce12f5 --- /dev/null +++ b/640/InvasionFront_CD3_block19_x1_y5_patient640_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5022.3, + "Centroid Y µm": 14217.5, + "Num Detections": 17903, + "Num Negative": 17268, + "Num Positive": 635, + "Positive %": 3.547, + "Num Positive per mm^2": 320.45 + } +} \ No newline at end of file diff --git a/640/InvasionFront_CD3_block19_x2_y5_patient640_1.json b/640/InvasionFront_CD3_block19_x2_y5_patient640_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d774ac47f9f61da878dd3c36098ab1802ae34c8 --- /dev/null +++ b/640/InvasionFront_CD3_block19_x2_y5_patient640_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7371.1, + "Centroid Y µm": 14392.4, + "Num Detections": 19136, + "Num Negative": 18334, + "Num Positive": 802, + "Positive %": 4.191, + "Num Positive per mm^2": 336.31 + } +} \ No newline at end of file diff --git a/640/InvasionFront_CD8_block19_x1_y5_patient640_0.json b/640/InvasionFront_CD8_block19_x1_y5_patient640_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0a1a64bd792923000a34934e4b352328570a66d9 --- /dev/null +++ b/640/InvasionFront_CD8_block19_x1_y5_patient640_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4572.6, + "Centroid Y µm": 22188.3, + "Num Detections": 10983, + "Num Negative": 10730, + "Num Positive": 253, + "Positive %": 2.304, + "Num Positive per mm^2": 176.24 + } +} \ No newline at end of file diff --git a/640/InvasionFront_CD8_block19_x2_y5_patient640_1.json b/640/InvasionFront_CD8_block19_x2_y5_patient640_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b4c33e89279245e78f7cf0cfc0708d8658f5e71f --- /dev/null +++ b/640/InvasionFront_CD8_block19_x2_y5_patient640_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7021.3, + "Centroid Y µm": 22288.2, + "Num Detections": 14209, + "Num Negative": 14105, + "Num Positive": 104, + "Positive %": 0.7319, + "Num Positive per mm^2": 59.36 + } +} \ No newline at end of file diff --git a/640/TumorCenter_CD3_block19_x1_y5_patient640_0.json b/640/TumorCenter_CD3_block19_x1_y5_patient640_0.json new file mode 100644 index 0000000000000000000000000000000000000000..485cdac6894b7bc9b7a72dd7ad54c55572cccfca --- /dev/null +++ b/640/TumorCenter_CD3_block19_x1_y5_patient640_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4447.6, + "Centroid Y µm": 14867.1, + "Num Detections": 12248, + "Num Negative": 12077, + "Num Positive": 171, + "Positive %": 1.396, + "Num Positive per mm^2": 95.96 + } +} \ No newline at end of file diff --git a/640/TumorCenter_CD3_block19_x2_y5_patient640_1.json b/640/TumorCenter_CD3_block19_x2_y5_patient640_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e71ae6c46feee78ad176c84a7eaec38d5879e013 --- /dev/null +++ b/640/TumorCenter_CD3_block19_x2_y5_patient640_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6721.4, + "Centroid Y µm": 14517.3, + "Num Detections": 12210, + "Num Negative": 11401, + "Num Positive": 809, + "Positive %": 6.626, + "Num Positive per mm^2": 460.84 + } +} \ No newline at end of file diff --git a/640/TumorCenter_CD8_block19_x1_y5_patient640_0.json b/640/TumorCenter_CD8_block19_x1_y5_patient640_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a03aa380faa170bf71dfc9b1e1c23cbdd29ead49 --- /dev/null +++ b/640/TumorCenter_CD8_block19_x1_y5_patient640_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6246.7, + "Centroid Y µm": 23787.4, + "Num Detections": 16240, + "Num Negative": 16181, + "Num Positive": 59, + "Positive %": 0.3633, + "Num Positive per mm^2": 31.21 + } +} \ No newline at end of file diff --git a/640/TumorCenter_CD8_block19_x2_y5_patient640_1.json b/640/TumorCenter_CD8_block19_x2_y5_patient640_1.json new file mode 100644 index 0000000000000000000000000000000000000000..48f81cfc6eb7029ecc8376eb3356901bd15824f5 --- /dev/null +++ b/640/TumorCenter_CD8_block19_x2_y5_patient640_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9070.2, + "Centroid Y µm": 23737.4, + "Num Detections": 17295, + "Num Negative": 16618, + "Num Positive": 677, + "Positive %": 3.914, + "Num Positive per mm^2": 335.05 + } +} \ No newline at end of file diff --git a/640/history_text.txt b/640/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ed8b8b511e807067e6ff2118b50534c8eb2ac23 --- /dev/null +++ b/640/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma G2. This extends transglottically with infiltration of the pre-epiglottic soft tissues. Therefore, the above-mentioned surgery is indicated. A larynx-preserving procedure does not appear promising due to the oncological situation. \ No newline at end of file diff --git a/640/icd_codes.txt b/640/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce1602050d47d2df39c878f258f13fc1bb6f114c --- /dev/null +++ b/640/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 B] \ No newline at end of file diff --git a/640/ops_codes.txt b/640/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..db0e710f7f782f8e3d162714c2f4e644eaa5c83e --- /dev/null +++ b/640/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie[5-303.xx ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion Sonstige[5-295.1x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/640/patient_clinical_data.json b/640/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8a8ecb1882f2edffdae28fe1e3c9a162ef9f7163 --- /dev/null +++ b/640/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/640/patient_pathological_data.json b/640/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..764b243f22ea53bb41d4db2f4174d7c6f7d5a006 --- /dev/null +++ b/640/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "640", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/640/surgery_description.txt b/640/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f2237a24107751eae4ea1a8b1d2b91bbccd2b8ac --- /dev/null +++ b/640/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Pharyngo- and laryngoscopy, Provox placement diff --git a/640/surgery_report.txt b/640/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c62eb03fcea66849ed76c7d2b68fd7cfba9be80b --- /dev/null +++ b/640/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthesia colleagues, skin disinfection, injection of a total of 10 ml Ultracaine 1% with adrenaline into both sides of the neck. Sterile draping. First creation of an apron flap in the typical manner. Then neck dissection on both sides. First on the left: Exposure of the sternocleidomastoid muscle, digastric muscle, omohyoid muscle. Exposure of the internal jugular vein, external jugular vein, internal carotid artery, external carotid artery, superior thyroid artery. Exposure, neurolysis and re-embedding of the vagus nerve, hypoglossal nerve, accessorius nerve and branches of the cervical plexus. This is followed by a level II-IV evacuation as well as level V a and parts of V b. Neck dissection on the right side: This is performed in the same way as on the left side, exposing and preserving the structures mentioned. Level II-V evacuation here too. Subsequent laryngectomy: visualization of the hyoid bone and removal of the hyoid bone with parts of the supragottic musculature due to the pre-epiglottic soft tissue infiltration underneath. The soft tissue can be removed up to the pharyngeal tube. No tumor infiltrates here. Then skeletonize the larynx, first on the left and then on the right. Expose the superior cornu in each case. Separate the infrahyoid muscles and strike them latero-caudally. Dissect the lobe of the thyroid gland and also strike it latero-caudally. Dissect the trachea. Then dissection of the pharyngeal tube and dissection of the piriform sinus on both sides. Then enter the larynx at the level of the epiglottis. Removal of the epiglottis. This is isolated along the mucosal border. The tumor is seen endolaryngeally in corresponding, almost complete filling of the endolaryngeal lumen. Dissection of the pharyngeal tube from the larynx in the postcricoid area. Successive caudal development of the larynx. Prior to this, the trachea was opened and the laryngectomy tube was replaced with a tracheotomy tube. The trachea was first fixed to the skin using two sutures. The larynx can then be removed after the connections to the pharyngeal tube or oesophagus have been completely loosened. Macroscopically far from healthy. The pre-epiglottic soft tissue infiltrations are also well covered with the resected suprahyoid muscle parts. The specimen is suture-marked in the area of the hyoid bone and the pre-epiglottic soft tissue insertion margin and is sent for final assessment. Myotomy is then performed. For this purpose, the left lateral constrictor pharyngis muscle or pars fundiformis is cut through to the mucosa over a length of approx. 3 cm. Provox insertion is then made. For this, a mid-dorsal puncture is made approx. 1 cm below the tracheal margin and a size 8 Provox prosthesis is inserted without complications. The previously removed tracheal tube is then reinserted. Successive pharyngeal suturing. First layer using inverting single-button sutures. Then second layer using inverting single-button sutures, also with Vicyl 3-0 single-button sutures. The third layer involves suturing the constrictor muscles. Subsequently, as after tumor removal, extensive irrigation of the surgical area with hydrogen and Ringer's solution. Careful hemostasis. Wound closure in layers and insertion of a Redon drainage in both sides of the neck. The tracheostoma is epithelized in the typical manner. Final wrap dressing. Final discussion with the anesthetist. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please provide post-operative nutrition via the inserted gastric tube for seven to ten days, followed by gruel and, if necessary, a diet. Please continue intraoperative antibiotics with Unacid for approx. one week. Wait for the final histological findings and discuss further in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/641/InvasionFront_CD3_block7_x3_y12_patient641_0.json b/641/InvasionFront_CD3_block7_x3_y12_patient641_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebc3ce84f94adb9856895506eab512910a18aad4 --- /dev/null +++ b/641/InvasionFront_CD3_block7_x3_y12_patient641_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11568.9, + "Centroid Y µm": 28984.7, + "Num Detections": 17863, + "Num Negative": 16744, + "Num Positive": 1119, + "Positive %": 6.264, + "Num Positive per mm^2": 475.65 + } +} \ No newline at end of file diff --git a/641/InvasionFront_CD3_block7_x4_y12_patient641_1.json b/641/InvasionFront_CD3_block7_x4_y12_patient641_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4934dcb572841da64a9b41a1fc00afe7cac967b6 --- /dev/null +++ b/641/InvasionFront_CD3_block7_x4_y12_patient641_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 28909.7, + "Num Detections": 21747, + "Num Negative": 19817, + "Num Positive": 1930, + "Positive %": 8.875, + "Num Positive per mm^2": 842.83 + } +} \ No newline at end of file diff --git a/641/InvasionFront_CD8_block7_x3_y12_patient641_0.json b/641/InvasionFront_CD8_block7_x3_y12_patient641_0.json new file mode 100644 index 0000000000000000000000000000000000000000..86807b74206d84aea40fe97d496f1e4332abb71e --- /dev/null +++ b/641/InvasionFront_CD8_block7_x3_y12_patient641_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10594.4, + "Centroid Y µm": 30084.1, + "Num Detections": 20137, + "Num Negative": 18819, + "Num Positive": 1318, + "Positive %": 6.545, + "Num Positive per mm^2": 564.15 + } +} \ No newline at end of file diff --git a/641/InvasionFront_CD8_block7_x4_y12_patient641_1.json b/641/InvasionFront_CD8_block7_x4_y12_patient641_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f27c226416cee1f85f089167d2930c733c5d8f0 --- /dev/null +++ b/641/InvasionFront_CD8_block7_x4_y12_patient641_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 30284.0, + "Num Detections": 21041, + "Num Negative": 18586, + "Num Positive": 2455, + "Positive %": 11.67, + "Num Positive per mm^2": 1059.8 + } +} \ No newline at end of file diff --git a/641/TumorCenter_CD3_block7_x3_y12_patient641_0.json b/641/TumorCenter_CD3_block7_x3_y12_patient641_0.json new file mode 100644 index 0000000000000000000000000000000000000000..09b228bf733b74f795fc2232fff1ced47584eef8 --- /dev/null +++ b/641/TumorCenter_CD3_block7_x3_y12_patient641_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 30134.0, + "Num Detections": 19659, + "Num Negative": 18549, + "Num Positive": 1110, + "Positive %": 5.646, + "Num Positive per mm^2": 510.77 + } +} \ No newline at end of file diff --git a/641/TumorCenter_CD3_block7_x4_y12_patient641_1.json b/641/TumorCenter_CD3_block7_x4_y12_patient641_1.json new file mode 100644 index 0000000000000000000000000000000000000000..77f2efe805edf21e4789b99c213f01cf9541c786 --- /dev/null +++ b/641/TumorCenter_CD3_block7_x4_y12_patient641_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 30184.0, + "Num Detections": 19267, + "Num Negative": 17407, + "Num Positive": 1860, + "Positive %": 9.654, + "Num Positive per mm^2": 870.91 + } +} \ No newline at end of file diff --git a/641/TumorCenter_CD8_block7_x3_y12_patient641_0.json b/641/TumorCenter_CD8_block7_x3_y12_patient641_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ed198385f15baf4b7d1ec58a96a4e965d9b2d373 --- /dev/null +++ b/641/TumorCenter_CD8_block7_x3_y12_patient641_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10644.4, + "Centroid Y µm": 29859.2, + "Num Detections": 21089, + "Num Negative": 20687, + "Num Positive": 402, + "Positive %": 1.906, + "Num Positive per mm^2": 188.86 + } +} \ No newline at end of file diff --git a/641/TumorCenter_CD8_block7_x4_y12_patient641_1.json b/641/TumorCenter_CD8_block7_x4_y12_patient641_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5a9b04d89f7f8f912bdd7eab7412b40b57efbf22 --- /dev/null +++ b/641/TumorCenter_CD8_block7_x4_y12_patient641_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 29834.2, + "Num Detections": 21240, + "Num Negative": 20302, + "Num Positive": 938, + "Positive %": 4.416, + "Num Positive per mm^2": 442.07 + } +} \ No newline at end of file diff --git a/641/history_text.txt b/641/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/641/icd_codes.txt b/641/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45d2eca409f9787902f5bba4aeda97ed19776348 --- /dev/null +++ b/641/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/641/ops_codes.txt b/641/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c0606c795e0f58ed0624a14c3b5aa72a9e7d75e --- /dev/null +++ b/641/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.01 ] Elektrokoagulation Pharynxgewebe[5-292.30 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/641/patient_clinical_data.json b/641/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a9b250c639f51701ebfd9e1b2b6e4ac7486e0893 --- /dev/null +++ b/641/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/641/patient_pathological_data.json b/641/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a19815e6ab53c74d385a91fb3ab2287cf62c9877 --- /dev/null +++ b/641/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "641", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/641/surgery_description.txt b/641/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bea6539747c2ed3166f677fd52640bae6a01c447 --- /dev/null +++ b/641/surgery_description.txt @@ -0,0 +1 @@ +Transoral robot-assisted resection diff --git a/641/surgery_report.txt b/641/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..efe3eea14f65a1151c5a73356bd951c8a4a8c7a5 --- /dev/null +++ b/641/surgery_report.txt @@ -0,0 +1 @@ +After induction of intubation anesthesia and initial consultation with the anesthesia colleague, a pharyngoscopy was performed to inspect and determine the extent of the tumor. It can be seen that there is a narrow mucosal margin of about 2-3 mm between the lower pole of the right tonsil and the incipient exophytic mass. From there, the exophytic mass extends to the hypopharyngeal side wall with the extensions to the plica pharyngoepiglottica on the right side. The exophytic mass is only broadly attached to the posterior wall of the hypopharynx and has a relatively narrow base compared to the tumor volume. The mass is easily displaceable over the pharyngeal musculature. Then docking of the robot and insertion of the functional arms. With very good adjustability, the tumor can then be easily dissected from cranial to caudal using the Maryland grasping forceps and the monopolar spatula. Enter directly under the lower pole of the right tonsil. Then dissect laterally down to the pharyngeal muscles. Continue the incision along the pharyngeal muscles. Cut around the base of the tumor with a safety margin of about 3-5 mm. The dissection is then carried out successively further caudally with subtle hemostasis. Here the tumor is finally deposited at the pharyngoepiglottic plica. Now take representative margin samples from the anterior deposition area, the posterior deposition area, the deep deposition area at the wound bed and the caudal and cranial deposition margins. All margin samples are then sent for intraoperative frozen section diagnostics and are all found to be tumor-free. Subtle hemostasis is then performed. A vascular stump in the area of the hypopharyngeal side wall is dissected free and then carefully coagulated. Subsequently, the wound is dried even after the retractor has been relaxed. The creation of a tracheostoma is not necessary given the extent of the resection. The insertion of a nasogastric feeding tube is also not necessary. However, the patient should be given a diet with TE light food for the next few days. At the end of the procedure, another final consultation with the anesthesia colleagues. It was then agreed that the patient would be monitored postoperatively in the intensive care unit of the ENT clinic after the recovery phase. After the wound area has healed, two-stage neck dissection and PEG placement if necessary. \ No newline at end of file diff --git a/642/InvasionFront_CD3_block7_x5_y3_patient642_0.json b/642/InvasionFront_CD3_block7_x5_y3_patient642_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b9d87fc431b5d3fcee58cde91fca494bcb13326a --- /dev/null +++ b/642/InvasionFront_CD3_block7_x5_y3_patient642_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16705.7, + "Centroid Y µm": 6975.6, + "Num Detections": 14567, + "Num Negative": 14424, + "Num Positive": 143, + "Positive %": 0.9817, + "Num Positive per mm^2": 70.66 + } +} \ No newline at end of file diff --git a/642/InvasionFront_CD3_block7_x6_y3_patient642_1.json b/642/InvasionFront_CD3_block7_x6_y3_patient642_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fadab9b93f2b7337617d63431a1861cec1bd406b --- /dev/null +++ b/642/InvasionFront_CD3_block7_x6_y3_patient642_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19129.4, + "Centroid Y µm": 7042.2, + "Num Detections": 16501, + "Num Negative": 13409, + "Num Positive": 3092, + "Positive %": 18.74, + "Num Positive per mm^2": 1825.0 + } +} \ No newline at end of file diff --git a/642/InvasionFront_CD8_block7_x5_y3_patient642_0.json b/642/InvasionFront_CD8_block7_x5_y3_patient642_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4f95110f52935371e0371efbf2c36924caba4dce --- /dev/null +++ b/642/InvasionFront_CD8_block7_x5_y3_patient642_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18377.8, + "Centroid Y µm": 8370.6, + "Num Detections": 13184, + "Num Negative": 13127, + "Num Positive": 57, + "Positive %": 0.4323, + "Num Positive per mm^2": 30.35 + } +} \ No newline at end of file diff --git a/642/InvasionFront_CD8_block7_x6_y3_patient642_1.json b/642/InvasionFront_CD8_block7_x6_y3_patient642_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6a0c7841ee54a979d7f3abce5507ed1f33dd71d3 --- /dev/null +++ b/642/InvasionFront_CD8_block7_x6_y3_patient642_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20876.4, + "Centroid Y µm": 8682.9, + "Num Detections": 16408, + "Num Negative": 15182, + "Num Positive": 1226, + "Positive %": 7.472, + "Num Positive per mm^2": 757.14 + } +} \ No newline at end of file diff --git a/642/TumorCenter_CD3_block7_x5_y3_patient642_0.json b/642/TumorCenter_CD3_block7_x5_y3_patient642_0.json new file mode 100644 index 0000000000000000000000000000000000000000..41a0e508290b9d60236363a6b5cfe19b20625983 --- /dev/null +++ b/642/TumorCenter_CD3_block7_x5_y3_patient642_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 7396.1, + "Num Detections": 17910, + "Num Negative": 16991, + "Num Positive": 919, + "Positive %": 5.131, + "Num Positive per mm^2": 414.83 + } +} \ No newline at end of file diff --git a/642/TumorCenter_CD3_block7_x6_y3_patient642_1.json b/642/TumorCenter_CD3_block7_x6_y3_patient642_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69943fadc136a7b77214fb008c7b5b28851e85a5 --- /dev/null +++ b/642/TumorCenter_CD3_block7_x6_y3_patient642_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 7621.0, + "Num Detections": 21040, + "Num Negative": 20015, + "Num Positive": 1025, + "Positive %": 4.872, + "Num Positive per mm^2": 400.84 + } +} \ No newline at end of file diff --git a/642/TumorCenter_CD8_block7_x5_y3_patient642_0.json b/642/TumorCenter_CD8_block7_x5_y3_patient642_0.json new file mode 100644 index 0000000000000000000000000000000000000000..51ba37da8b6b6c122a3c538558365c6e4b7a815f --- /dev/null +++ b/642/TumorCenter_CD8_block7_x5_y3_patient642_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 7745.9, + "Num Detections": 19418, + "Num Negative": 19170, + "Num Positive": 248, + "Positive %": 1.277, + "Num Positive per mm^2": 124.68 + } +} \ No newline at end of file diff --git a/642/TumorCenter_CD8_block7_x6_y3_patient642_1.json b/642/TumorCenter_CD8_block7_x6_y3_patient642_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c54a74a186e86f303f9469f9a33d0e77a27c448e --- /dev/null +++ b/642/TumorCenter_CD8_block7_x6_y3_patient642_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 7845.8, + "Num Detections": 21748, + "Num Negative": 21554, + "Num Positive": 194, + "Positive %": 0.892, + "Num Positive per mm^2": 75.94 + } +} \ No newline at end of file diff --git a/642/history_text.txt b/642/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/642/ops_codes.txt b/642/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a4490b2a0f435192c472704f8f1f088dbbeb7437 --- /dev/null +++ b/642/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Sonstige radikale Resektion des Pharynx [Pharyngektomie][5-296.xx ] Sonstige partielle Laryngektomie[5-302.x ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/642/patient_clinical_data.json b/642/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5baffb4c13e376ca6cdac12bfd8068ff059e6550 --- /dev/null +++ b/642/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/642/patient_pathological_data.json b/642/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..78af7d9c8eedf17e27f1c67489c1e5fc9d001306 --- /dev/null +++ b/642/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "642", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/643/InvasionFront_CD3_block15_x5_y8_patient643_0.json b/643/InvasionFront_CD3_block15_x5_y8_patient643_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8ebc53713150e7e6fd0e7133d0e3fbb8361faf9f --- /dev/null +++ b/643/InvasionFront_CD3_block15_x5_y8_patient643_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 29784.2, + "Num Detections": 13660, + "Num Negative": 12677, + "Num Positive": 983, + "Positive %": 7.196, + "Num Positive per mm^2": 573.16 + } +} \ No newline at end of file