diff --git a/721/ops_codes.txt b/721/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0f01b5a6b39003e6cd82d799cd17116566a592e --- /dev/null +++ b/721/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 6 Regionen[5-403.22 B] Revision Tracheostomie[5-316.x ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/721/surgery_description.txt b/721/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7a609f70cc31cff46f4291b21ecf6a99fdc96e97 --- /dev/null +++ b/721/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy with partial pharyngectomy and reconstruction, Neck dissection diff --git a/721/surgery_report.txt b/721/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..74686e48861ed951083eeb9715e86573673c0dfe --- /dev/null +++ b/721/surgery_report.txt @@ -0,0 +1 @@ +First, after intubation via the existing tracheostoma, perform a pharyngo-/laryngoscopy: enter with the small bore tube under dental protection after inspecting the inconspicuous oral vestibule. An inconspicuous oral cavity including the floor of the mouth, tongue and soft palate is revealed. The oropharynx shows inconspicuous tonsil regions and posterior pharyngeal wall. The vallecula appears submucosally bulging, but there is still no exophytic tumor growth. The epiglottis is extremely displaced, there is an extensive, almost completely submucosal tumor that completely consumes the larynx. Careful inspection. The posterior wall of the hypopharynx and the lateral wall, including the piriform sinus, are completely free on the left, as is the free esophageal entrance; parts of the lateral wall of the hypopharynx are also free on the right. The piriform sinus is fixed and infiltrated by the tumor. Extensive extralaryngeal growth is palpated on the right side. Flexible esophagogastroscopy is now performed: an extensive scar is seen in the case of extensive gastrointestinal bleeding in 2010. With normal conditions in the gastric region and excellent diaphanoscopy, the stomach is now punctured without any problems and the PEG tube is inserted using the thread pull-through method without any problems. Inconspicuous esophagus on reflection. The patient is now repositioned. First of all, an apron flap is created by cutting around the old tracheostoma over a large area. Cut through the skin and subcutaneous tissue. Creation of the apron flap taking into account the platysma salt layer. Exposure of the sternocleidomastoid muscle on both sides. The extralaryngeal tumor growth can now be easily palpated. The thyroid gland is clearly enlarged but symmetrical and soft, and the infrahyoid muscles are not infiltrated. Initially start by detaching the tumorous process from the left side. To do this, first perform the neck dissection in the anterior region. Expose the submandibular gland. Exposure of the digastric muscle. Exposure and preservation of the facial vein. Dissection of the internal jugular vein. Exposure and preservation of the hypoglossal nerve. Exposure and preservation of the extremely strong superior thyroid artery. Exposure of the common carotid artery. The neck preparation is turned medially towards the tumor. This is followed by exposure of the thyroid cartilage horn. Release and ligation of the laryngeal bundle. Careful dissection and release of the piriform sinus. Exposure and release of the hyoid. This is clearly free on the left side. Dissection of the infrahyoid musculature. Dissection of the trachea on the left side. Left-sided resection of the thyroid isthmus. The pharynx is now entered between the thyroid cartilage and the hyoid, in the area of the left-sided vallecula, transition to the pharyngeal side wall. Free conditions here after inspection. Gradually widen the pharyngotomy and widen the mucosal incision. For a better overview, the lingual artery must be ligated and removed. It can now be seen that the epiglottis is also free on the left side. The vallecula is clearly tumor-free. Therefore, the mucosal incision is now extended along the aryepiglottic fold on the left and in the area of the vallecula. Successive release of the tumor. On the right side, the tumor appears to have at least contact with the hyoid, so the lateral right third is now resected. Now perform a parallel resection of the cervical sheath on the right side. The procedure is basically the same as on the opposite side. Expose the submandibular gland. Expose the digastric muscle. Exposure of the internal jugular vein. The facial vein moves towards the tumor and is removed after ligation. Careful dissection and preservation of the hypoglossal nerve. The superior thyroid artery also runs into the tumor conglomerate and is also removed after ligation. Exposure of the common carotid artery. Exposure of the prevertebral fascia. Medial and caudal, also relatively right-sided resection of the thyroid isthmus. The thyroid isthmus is preserved on the specimen, but is not infiltrated macroscopically. The former tracheostoma is now completely excised. This is also inflammatory in depth, but without evidence of direct tumor infiltration. Now, after complete mobilization and exposure of the cervical vascular sheath, the tumour is resected. Circumscribed right paralaryngeal open tumor, but with clear and safe separation from the soft tissue of the neck. Otherwise, regular soft tissue remains on all sides of the tumor. Complete resection of the tumor with resection of the right-sided piriform sinus. The mucosa of the posterior wall can be completely preserved, also free esophageal entrance, no postcricoid growth. A small, exophytic, ulcerated area can be seen in the area of the right-sided piriform sinus, otherwise completely submucosal tumor. Removal of the trachea, taking the tracheostoma with it, and removal of the tumor macroscopically clearly in sano. The mucosal margin samples are now imaged circularly. Moderate grade dysplasia, but no higher grade dysplasia or CIS was diagnosed in the postcricoid region and the right-sided hypopharynx. Completely free conditions on the left side. Therefore, no further resections were performed here. After inspection, the subglottic area was clear and wide. A Provox prosthesis is now fitted. Due to the inflammatory changes in the tracheostoma, conditions were somewhat more difficult, also due to the deep-seated trachea. The Provox prosthesis is inserted as cranially as possible. This is technically successful without any problems. The neck dissection is then completed. In principle exactly the same procedure. First on the left side. Exposure of the accessorius nerve. Release the accessorius triangle while carefully protecting the nerve. Release of level V with careful protection of the cervical plexus branches. Isolated ligation of a strong inflow to the thoracic duct. This can be easily visualized. Absolutely dry conditions here and no further measures. Complete exposure of the internal jugular vein beforehand. Careful wound inspection and turning to the opposite side. Level VI was removed en bloc with the preparation. Same procedure on the right side. Exposure of the accessorius nerve. Clearing of the accessorius triangle with careful protection of the nerve. Release of V a with careful protection of the cervical plexus branches. Ligation of the transverse cervical artery and coagulation of the right occipital artery. Careful wound inspection and hemostasis. Careful, two-layer pharyngeal suture with 3.0 mucosal suture, submucosal and inverting. Finally, good invasion of the 1st pharyngeal suture and tight conditions. Good mucosal conditions with preserved submucosal tissue. Mobilization of the detached thyroid gland is now performed, allowing a wide and large soft tissue mantle to be created on the pharyngeal tube. Suturing with 2.0 Vicryl. Final wound inspection. Insertion of a 10 Redon drain and cervical two-layer wound closure. Insertion of the tracheostoma. Clearly more difficult conditions here. Due to the inflammatory conditions in the area of the trachea and the relatively short tracheal stump, there is a slight tilting of the Provox prosthesis. Otherwise intact conditions on all sides. At the end of the operation, reintubation to a 10 mm tracheoflex cannula without any problems. Finally, also at the patient's request, removal of a left buccal atheroma, which has been present for many years. Also several atheroma-specific lesions distributed over the head. A curved skin incision is now made in the case of disturbing findings on the left buccal side. Cut through the skin. Excision of the directly subcutaneous mass, macroscopically and clinically clearly corresponding to an atheroma. Careful release strictly at the atheroma capsule. Therefore, protect the surrounding soft tissue. Meticulous hemostasis followed by careful, two-layer wound closure and completion of the procedure at this point without any indication of complications. Conclusion: Intraoperatively R0-resected cT4a cN2b glottic laryngeal carcinoma. Please perform a postoperative X-ray gruel swallow on the 9th postoperative day if the wound conditions are normal. In the area of the trachea, first wait for the wound to heal completely and then assess the Provox prosthesis. \ No newline at end of file diff --git a/722/history_text.txt b/722/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c0f1099634d02fb7d3368f20e28dd347a40bea4 --- /dev/null +++ b/722/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the left hypopharynx with invasion into the larynx. The above-mentioned operation was therefore indicated. The patient was also informed in detail about defect coverage using a microvascular pedicled flap. \ No newline at end of file diff --git a/722/icd_codes.txt b/722/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aaa451887d7597f659eda671735d6f6a3b53cbe7 --- /dev/null +++ b/722/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] Hypopharynxkarzinom[C13.9 ] \ No newline at end of file diff --git a/722/ops_codes.txt b/722/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..153b548fc0145e8df4c792b4f1c5bf8d31072cf9 --- /dev/null +++ b/722/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Selektive Neck dissection in 5 Regionen[5-403.04 L] Permanente Tracheotomie[5-312.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme von Spalthaut am Oberschenkel[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/722/surgery_description.txt b/722/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e2991eca55df40a8471f1b47b11d6ec90096fb8 --- /dev/null +++ b/722/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Free flap (Radial) diff --git a/722/surgery_report.txt b/722/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3e557b69c8d7160184cef35f6c65e006aad40f90 --- /dev/null +++ b/722/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again: The exophytic tumor is seen in the area of the hypopharyngeal side wall, passing over the anterior hypopharyngeal wall on the left to the postcricoid region and occupying it almost completely. The tumor also invades the left laryngeal skeleton via the arytenoid fold, thus confirming the indication for surgery. The patient is now repositioned: First neck dissection and tumor resection: creation of an apron flap in typical subplatysmal fashion. Then neck dissection on the right side: exposure of the digastric and omohyoid muscles. Dissection of the lymph node fat packet from the sternocleidomastoid muscle. Exposure of the cervical vascular sheath, internal jugular vein, common carotid artery. Internal carotid artery, external. Exposure of vagus nerve, hypoglossal nerve and accessorius nerve. Successive removal of the lymph nodes and fatty tissue from levels II-V, also by preserving branches of the cervical plexus. Neck dissection on the left side: This shows a conglomerate of cranial lymph nodes in level II, showing the omohyoid muscle and digastric muscle. The latter has grown together with the conglomerate and is also resected. Underlying the hypoglossal nerve. This runs through the middle of the lymph node conglomerate and must also be resected. Parts of the sternocleidomastoid muscle must also be resected in the cranial area. The internal jugular vein is also involved in the tumor process and must also be resected. It is exposed caudally and ligated twice. The lymph node conglomerate along the carotid artery and vagus nerve is then removed. Here, the mass must be dissected with some effort, particularly in the area of the bifurcation, but there is no tumor infiltration. Cranial exposure of the internal jugular vein and removal and double ligation of the vein also cranially in the vicinity of the jugular foramen. The accessorius nerve can be exposed and preserved here. Overall, level II-V evacuation as part of radical neck dissection. Subsequent tumor resection: First remove the level VI package, this is sent separately for histology. Then separation of the infrahyoid muscles from the hyoid bone. Subsequently detachment of the suprahyoid muscles from the hyoid bone. Exposure of the right superior cornu and separation of the piriform sinus. Separate the thyroid gland caudally and strike it caudo-laterally on both sides. On the left, the superior cornu is not released as it is located close to the tumor. Then enter the pharyngeal space above the level of the hyoid bone. Expose the tumor. The tumor is successively removed with a safety margin of at least 1.5 mm on all sides. This initially results in a partial pharyngectomy with laryngectomy. Laryngeal skeleton is released caudally with attached tumor and pharyngeal tube. Caudal creation of a tracheotomy and reintubation. Caudal suture of the trachea. The tumor preparation is then detached by cutting around a cranial tongue. The tumor specimen is marked with a suture. In addition, a caudal margin sample is taken and sent for frozen section. Unfortunately, carcinoma in situ infiltrate can still be seen in the left lateral, cranial and caudal tumor specimen. There is also carcinoma in situs in the area of the caudal margin sample. Therefore, margin samples are necessary at several locations. Extensive margin samples are taken approx. 1 cm wide caudally, laterally on the left and cranially. These are marked remote from the tumor and on the lateral suture. No more tumor infiltrates are visible here during the assessment. This ultimately results in a subtotal pharyngectomy. Due to the situation, defect coverage with a microvascular radial flap is now indicated. Provox prosthesis is not possible or sensible due to the overall situation and the proximity of the end of the defect to the potential Provox prosthesis site. However, a left myotomy has already been performed as part of the operation. The muscles of the cricopharyngeal muscle on the left side were completely severed over a length of 3-4 cm. Careful attention was paid to intact mucosa. This is followed by careful hemostasis and irrigation of the entire wound area. Now remove the left forearm flap: Marking of the defect size including skin monitor. Defect size 1.5 x 10 cm. Cut around the flap, initially ulnarly. Subsequently, dissection of the skin with some attached subcutaneous tissue and placement of a subcutaneous incision for skin monitoring. Extend the incision cranially to the crook of the elbow. Release of the skin monitor with subcutaneous tissue and superficial venous system. Release of the flap from radial, subfascial. Distal exposure of the radial artery. This is clamped for several times, here no changes in saturation, which is always 97-100 %. Subsequently, the radial artery is removed and treated cranially and caudally with 4-0 prolene sutures as a puncture. Successive elevation of the flap with deep pedicle, which was previously exposed under the brachioradialis muscle. Outgoing vessels are bipolarly coagulated and treated with clips. Exposure of a radial vein and cephalic vein through the antecubital fossa, which offers two outlets. Removal of the flap. The veins are ligated and the artery is treated with 6-0 Vascufil sutures. Spray the flap with heparin solution. Then successive insertion of the flap into the defect in the pharyngeal area. Incision of the skin at the esophageal entrance to improve the massage through the upper esophagus. Successive suturing of the flap with 3-0 or 4-0 Vicryl single-button sutures. This results in tension-free complete closure of the defect. The stalk is inserted cranially into the right side of the neck. Conditioning of the superior thyroid artery. Anastomosis with the conditioned radial artery using 8-0 Ethilon single-button sutures. After opening the clamps, good arterial flow, good venous return. V. radialis is anastomosed with an outlet from the A. facialis using a 2-0 coupler. Here too, good venous return after opening the clamp, positive smear phenomenon. A further vein which is branching off from the internal jugular vein is anastomosed with a branch from the cephalic vein, also using a 2.5 coupler. Again, after opening the clamp, good venous return, positive smear phenomenon. The remaining outlet from the cephalic vein is tilted close to the outlet. This is followed by irrigation of the entire wound area. Careful hemostasis. A Redon drain is inserted into each side of the neck on the right. The thyroid gland is adapted above the caudal part of the flap using 3-0 Vicryl sutures. Likewise the remaining infrahyoid muscles. Skin closure with suturing of the apron flap to the trachea and epithelialization of the tracheostoma. The skin monitor is sutured in place without tension via a small median incision. Good aspect. Tracheal cannula size 10 is placed and fixed with sutures. Closure of the forearm defect: approx. 0.7-0.8 mm thick split skin is removed from the thigh using the dermatome in a typical manner. The cranial parts of the wound on the forearm are sutured in layers. The defect is closed with the split skin, which is successively incorporated while protecting vascular and neuronal structures. Finally, a hydrogel-Mepilex dressing is applied and a loose compress bandage is placed over it and fixed with absorbent cotton. The arm is adjusted to a functional position on a Cramer splint and fixed with a flexible bandage. Loosening of the arm. Arm always well supplied with blood. Saturation between 95 and 100 %. The superficial wound area on the thigh is covered with a hydrocolloid dressing. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. The antibiotic treatment that was started intraoperatively should be continued with Unacid for 2-3 days. Heparin perfusor with 500 E/h, which was started intraoperatively, should be continued postoperatively for at least 5 days. Flap control for at least 5 days according to the scheme via Doppler control and control of the skin monitor. Leave the intraoperatively inserted gastric tube in place, feed via the previously inserted PEG tube for at least 10 days, then swallow porridge and, if necessary, build up the diet. Overall cT4a hypopharyngeal carcinoma with invasion of the left laryngeal skeleton. Under subtotal pharyngectomy, defect coverage by means of microvascularly pedicled radial flap from the left side necessary. Overall, given the size of the tumor, postoperative free chemotherapy is indicated. \ No newline at end of file diff --git a/723/InvasionFront_CD3_block1_x6_y7_patient723_1.json b/723/InvasionFront_CD3_block1_x6_y7_patient723_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bf2099f8ab27cea90480b602e1aa19ec5574d59b --- /dev/null +++ b/723/InvasionFront_CD3_block1_x6_y7_patient723_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 19589.6, + "Num Detections": 31070, + "Num Negative": 29095, + "Num Positive": 1975, + "Positive %": 6.357, + "Num Positive per mm^2": 679.86 + } +} \ No newline at end of file diff --git a/723/InvasionFront_CD8_block1_x5_y7_patient723_0.json b/723/InvasionFront_CD8_block1_x5_y7_patient723_0.json new file mode 100644 index 0000000000000000000000000000000000000000..50c5586761233f15eb555241a156857c28613624 --- /dev/null +++ b/723/InvasionFront_CD8_block1_x5_y7_patient723_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 18090.4, + "Num Detections": 28965, + "Num Negative": 27937, + "Num Positive": 1028, + "Positive %": 3.549, + "Num Positive per mm^2": 392.32 + } +} \ No newline at end of file diff --git a/723/TumorCenter_CD3_block1_x5_y9_patient723_0.json b/723/TumorCenter_CD3_block1_x5_y9_patient723_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fd637ab9f558578719ad579439d7a7463eef9df0 --- /dev/null +++ b/723/TumorCenter_CD3_block1_x5_y9_patient723_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15991.5, + "Centroid Y µm": 22338.2, + "Num Detections": 7680, + "Num Negative": 5807, + "Num Positive": 1873, + "Positive %": 24.39, + "Num Positive per mm^2": 1884.3 + } +} \ No newline at end of file diff --git a/723/TumorCenter_CD3_block1_x6_y9_patient723_1.json b/723/TumorCenter_CD3_block1_x6_y9_patient723_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d3cf65514d6e1956621a56bc177301c0972f6e42 --- /dev/null +++ b/723/TumorCenter_CD3_block1_x6_y9_patient723_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 22288.2, + "Num Detections": 19139, + "Num Negative": 15576, + "Num Positive": 3563, + "Positive %": 18.62, + "Num Positive per mm^2": 1556.2 + } +} \ No newline at end of file diff --git a/723/TumorCenter_CD8_block1_x5_y7_patient723_0.json b/723/TumorCenter_CD8_block1_x5_y7_patient723_0.json new file mode 100644 index 0000000000000000000000000000000000000000..87bcdead380b1de92fa23f7d146ff090697de144 --- /dev/null +++ b/723/TumorCenter_CD8_block1_x5_y7_patient723_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 26261.1, + "Num Detections": 27307, + "Num Negative": 26788, + "Num Positive": 519, + "Positive %": 1.901, + "Num Positive per mm^2": 207.14 + } +} \ No newline at end of file diff --git a/723/TumorCenter_CD8_block1_x6_y7_patient723_1.json b/723/TumorCenter_CD8_block1_x6_y7_patient723_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e603d09cf66db6009ea223da456ab860c893459f --- /dev/null +++ b/723/TumorCenter_CD8_block1_x6_y7_patient723_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21388.7, + "Centroid Y µm": 26236.1, + "Num Detections": 31929, + "Num Negative": 31201, + "Num Positive": 728, + "Positive %": 2.28, + "Num Positive per mm^2": 273.72 + } +} \ No newline at end of file diff --git a/723/history_text.txt b/723/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/723/icd_codes.txt b/723/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..51d27559e29fda3e02ec96abccab5997580fac77 --- /dev/null +++ b/723/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/723/ops_codes.txt b/723/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c65294cacb89ab8b71727bafb998e41a66fb8133 --- /dev/null +++ b/723/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Extraktion mehrere Zähne verschiedener Quadranten[5-230.3 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] \ No newline at end of file diff --git a/723/patient_clinical_data.json b/723/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7639ab9f38357c7413a9346aeaff8b451cbf06f8 --- /dev/null +++ b/723/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/723/patient_pathological_data.json b/723/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..51361c581406f1b89e661244590683921a380599 --- /dev/null +++ b/723/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "723", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 55, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/723/surgery_description.txt b/723/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d64d9db787c361e0ee15fd23ff94f29333304c0 --- /dev/null +++ b/723/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection (Level I-V), Free flap (Radial), Defect coverage diff --git a/723/surgery_report.txt b/723/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..bff63977d16fb6aeb2d73ef33f96d0f1cab404dc --- /dev/null +++ b/723/surgery_report.txt @@ -0,0 +1 @@ +PEG insertion (): Placement of the PEG tube after flexible gastroesophagoscopy and performance of positive diaphanoscopy in the usual manner using the thread pull-through method. Removal of the left radial lobe (): Palpatory identification of the distal radial artery. Marking of the flap borders 9x7 cm on the distal forearm proximal to the retinaculum floxorom with an S-shaped incision running proximally into the cubital fossa. Cutaneous and subcutaneous incision starting proximally, identification and visualization of the venous confluence in the cubital fossa. The cephalic vein is well developed on this side. There are now already 2 large veins to the anastomosis in the cubital fossa. Now identify the external ramus of the radial nerve and leave the peritendineum of the tendon of the brachioradialis muscle and incise down to the forearm fascia, incise the fascia and then lift the flap fascially to the end of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendon and to spare the ulnar artery. The ulnar artery is spared, the radial artery is identified distally, palpated and clamped. Clamping of the vessels with the HDS clamp, after 5 minutes under good oxygen saturation measured by pulse oximetry on the palate, the vessels are removed with subsequent Ethibond 0 ligation. The successive detachment of the flap pedicle from the flexor pollicis longus muscle was performed. Larger perforators were treated with clips. The ulnar, brachial and radial arteries are identified proximally. The flap is then placed on the radial artery and 2 large veins in the cubital fossa are also placed, which are suitable for anastomosis. The flap is irrigated with heparin. Regular situation. The flap is now transferred for suturing and the arm is closed proximally in 2 layers with 4-0 Vicryl and 5-0 Ethilon. Distally, the resulting defect is sutured using split skin with 5-0 Ethilon. The previously fitted forearm splint is then applied and flap elevation is completed without complications. Tumor resection by and : Insertion of the McIvor oral retractor with the small spatula and adjustment of the site. This shows a coarse, ulcerated mass localized to the left tonsil lobe. Submucosally, the mass extends just above the cranial tonsil pole. The resection margins are determined in the presence of . Successive tumour resection after mobilization of the upper tumour pole under constant palpatory control. The resection is performed in healthy muscle tissue. Lateral parapharyngeal fat is visualized. Bleeding is stopped with the bipolar coagulation forceps. After cutting around the caudal pole of the tonsil, leaving a strip of the base of the tongue on the tumor resectate, the sutures are marked on all 4 quadrants. The resectate is sent in its entirety on cork for a frozen section histopathological examination. After 1 hour, the feedback is received that the tumor has been resected R0. All tumor margins are free. Subtle hemostasis in the tumor bed using bipolar coagulation forceps. Neck dissection is performed on the left side by : After infiltration with local anesthetic containing adrenaline, the corresponding arcuate skin incision is made. Sharp dissection through the cutis and subcutis with exposure of the sternocleidomastoid muscle. The large, easily displaceable metastasis is located immediately adjacent to this. This is first exposed on all sides, whereby the neck dissection specimen is successively dissected along the omohyoid muscle, digastric muscle with parts of the caudal parotid gland and the sternocleidomastoid muscle. Open the vascular nerve sheath caudally and dissect cranially. Expose the internal jugular vein and the common carotid artery as well as the vagus nerve in between, which can be spared until the end. Subsequently, successive cranial dissection with successive detachment of the large metastasis from the internal jugular vein, which is ultimately also successful in a healthy layer. The digastric muscle is followed ventrally from its anterior belly via its tendon to the posterior belly and the specimen is thus also dissected laterally. The hypoglossal nerve is preserved. Finally, the metastasis with the caudal parts of the parotid gland is completely detached from the vascular nerve sheath. The accessory nerve can also be preserved intact from region II. The neck dissection is then completed with resection of regions II to V so that the neck dissection specimen can be resected en bloc together with the large metastasis. The submandibular gland is then removed and region I cleared. In addition to the lingual nerve, the enoral defect that will later be used for the flap can also be seen here. Neck dissection on the right by and PJ: Skin incision on the anterior edge of the sternocleidomastoid muscle. Separation of the cutaneous and subcutaneous tissue. Exposure of the platysma and transection of the platysma. Snaring of the platysma and subplatysmal flap preparation. Ligation of the external jugular vein. Exposure of the auricular nerve and protection of the nerve. Now dissection in depth along the anterior edge of the sternocleidomastoid muscle. Expose the posterior digastric venter muscle and the omohyoid muscle. Insertion of blunt retractors and exposure of the cervical vascular nerve sheath. This is successively freed from the neck preparation. Now remove the neck preparation after visualization and release of the accessorius nerve from cranial to caudal, taking level II a, II b, III, IV and V. Insertion of a 10 Redon drain. Subtle hemostasis using bipolar coagulation forceps. Irrigation with hydrogen and Ringer and two-layer wound closure on the right side of the neck. Now the radialis graft is inserted by : looping the cranial flap end cervically with a clamp and pulling through the opening. Insertion of the graft into the tumor resection box. Flap fixation and suturing of the flap in single button sutures in the usual manner without complications. Inspection shows good closure with a well-fitting graft. Anastomoses through : After appropriate suturing of the flap enorally, the stalk is passed outwards and fixed with 2 retaining sutures. The arterial anastomosis is made to the superior thyroid artery on the left side. Venous drainage is then ensured by the two existing veins, which are connected to the internal jugular vein in an end-to-side manner. The tracheotomy is then created by : horizontal skin incision just below the cricoid over 2 cm. Separation of the cutaneous and subcutaneous tissue. Dissection into the fatty tissue and exposure of the infralaryngeal musculature, which is split in the middle and the thyroid isthmus is exposed. Undermining of the thyroid isthmus. Bipolar coagulation and transection with the scissors. Identification of the anterior tracheal wall and entry into the 2nd and 3rd intertracheal ring space. Incision of the tracheostoma in the usual manner using epithelializing single-button sutures. Insertion of a 9 mm tracheostomy tube and completion of the tracheostomy without complications. \ No newline at end of file diff --git a/724/InvasionFront_CD3_block13_x3_y3_patient724_0.json b/724/InvasionFront_CD3_block13_x3_y3_patient724_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b04e8b1d9449acb4477a48ce5a40fc23cb372a94 --- /dev/null +++ b/724/InvasionFront_CD3_block13_x3_y3_patient724_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11069.1, + "Centroid Y µm": 6946.3, + "Num Detections": 14597, + "Num Negative": 14222, + "Num Positive": 375, + "Positive %": 2.569, + "Num Positive per mm^2": 232.21 + } +} \ No newline at end of file diff --git a/724/InvasionFront_CD3_block13_x4_y3_patient724_1.json b/724/InvasionFront_CD3_block13_x4_y3_patient724_1.json new file mode 100644 index 0000000000000000000000000000000000000000..92df6cf0c4ece8d9abea12dec6170dcf2dfd61c0 --- /dev/null +++ b/724/InvasionFront_CD3_block13_x4_y3_patient724_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 6821.4, + "Num Detections": 16663, + "Num Negative": 16173, + "Num Positive": 490, + "Positive %": 2.941, + "Num Positive per mm^2": 262.94 + } +} \ No newline at end of file diff --git a/724/InvasionFront_CD8_block13_x3_y3_patient724_0.json b/724/InvasionFront_CD8_block13_x3_y3_patient724_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c4ced537924122122764e94843d339aff02f0bb --- /dev/null +++ b/724/InvasionFront_CD8_block13_x3_y3_patient724_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12593.3, + "Centroid Y µm": 8495.5, + "Num Detections": 14581, + "Num Negative": 14193, + "Num Positive": 388, + "Positive %": 2.661, + "Num Positive per mm^2": 235.73 + } +} \ No newline at end of file diff --git a/724/InvasionFront_CD8_block13_x4_y3_patient724_1.json b/724/InvasionFront_CD8_block13_x4_y3_patient724_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8ab6b16e27c2eedca8ab89139c1da7a06930d466 --- /dev/null +++ b/724/InvasionFront_CD8_block13_x4_y3_patient724_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15092.0, + "Centroid Y µm": 8545.5, + "Num Detections": 18394, + "Num Negative": 17929, + "Num Positive": 465, + "Positive %": 2.528, + "Num Positive per mm^2": 235.37 + } +} \ No newline at end of file diff --git a/724/TumorCenter_CD3_block13_x3_y3_patient724_0.json b/724/TumorCenter_CD3_block13_x3_y3_patient724_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba53512f9d841ee35c6e535458f504fc970a9863 --- /dev/null +++ b/724/TumorCenter_CD3_block13_x3_y3_patient724_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12568.3, + "Centroid Y µm": 13892.6, + "Num Detections": 17257, + "Num Negative": 16477, + "Num Positive": 780, + "Positive %": 4.52, + "Num Positive per mm^2": 389.72 + } +} \ No newline at end of file diff --git a/724/TumorCenter_CD3_block13_x4_y3_patient724_1.json b/724/TumorCenter_CD3_block13_x4_y3_patient724_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2a7fe7f23e3812d2f3733622fddbdaad0e10ffc5 --- /dev/null +++ b/724/TumorCenter_CD3_block13_x4_y3_patient724_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15067.0, + "Centroid Y µm": 14117.5, + "Num Detections": 16907, + "Num Negative": 16161, + "Num Positive": 746, + "Positive %": 4.412, + "Num Positive per mm^2": 380.65 + } +} \ No newline at end of file diff --git a/724/TumorCenter_CD8_block13_x3_y3_patient724_0.json b/724/TumorCenter_CD8_block13_x3_y3_patient724_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d480022be2d5346e309664219001dd112264ff3e --- /dev/null +++ b/724/TumorCenter_CD8_block13_x3_y3_patient724_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 8045.7, + "Num Detections": 15828, + "Num Negative": 15406, + "Num Positive": 422, + "Positive %": 2.666, + "Num Positive per mm^2": 212.6 + } +} \ No newline at end of file diff --git a/724/TumorCenter_CD8_block13_x4_y3_patient724_1.json b/724/TumorCenter_CD8_block13_x4_y3_patient724_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2d8ef53e7b7b61ccb51dfd61da42a06a2f45f05 --- /dev/null +++ b/724/TumorCenter_CD8_block13_x4_y3_patient724_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13268.0, + "Centroid Y µm": 7695.9, + "Num Detections": 15200, + "Num Negative": 14851, + "Num Positive": 349, + "Positive %": 2.296, + "Num Positive per mm^2": 181.79 + } +} \ No newline at end of file diff --git a/724/history_text.txt b/724/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef753a1ff14a11df061fb905b850b8428e4d7321 --- /dev/null +++ b/724/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed, extensive carcinoma located in the right hypopharynx and infiltrating the larynx over a wide area, including thyroid cartilage, extending cranially to the tonsil lobe. CT clearly shows thyroid cartilage infiltration by the tumor. Therefore, the above mentioned surgery is indicated. \ No newline at end of file diff --git a/724/icd_codes.txt b/724/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2024350312fe1ce64955beef46ede1d07af793cf --- /dev/null +++ b/724/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] Larynxkarzinom[C32.9 ] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/724/ops_codes.txt b/724/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..119dcea2a9872313eeb862f4bc8132249391a9e5 --- /dev/null +++ b/724/ops_codes.txt @@ -0,0 +1 @@ +Permanente Tracheostomaanlage[5-312.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Spalthaut Entnahmestelle sonstige[5-901.0x R] Wechsel Herzklappe onA[5-352.y ] Endarteriektomie einer Gefäßprothese an Arterien der Hand[5-381.28 L] Offen chirurgische Implantation von einem großlumigen ungecoverten Stent in künstliche Gefäße (Zusatzkode)[5-38e.0e ] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Offene pharyngozervikale Ösophagomyotomie[5-420.11 ] \ No newline at end of file diff --git a/724/patient_clinical_data.json b/724/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..778e883226acf164c89b30f37efea31f82588698 --- /dev/null +++ b/724/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/724/patient_pathological_data.json b/724/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9beae7262a4a9944385e391c31f4b649bbb981bb --- /dev/null +++ b/724/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "724", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris1", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 45.0 +} \ No newline at end of file diff --git a/724/surgery_description.txt b/724/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d76eb9c1a3d702990b3b8055f7486175b62004e6 --- /dev/null +++ b/724/surgery_description.txt @@ -0,0 +1 @@ +Pharyngectomy, Neck dissection, Free flap (Radial), Tracheotomy diff --git a/724/surgery_report.txt b/724/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5549467bbabb8b8a79b22691e874e2c29e9fdfd2 --- /dev/null +++ b/724/surgery_report.txt @@ -0,0 +1 @@ +: Induction of anesthesia and intubation by the anesthesiologist, then first of all, insertion of the small bore tube and examination of the tumor. It can be seen that the tumor already starts at the lower tonsil pole on the right side and extends along the hypopharyngeal side wall and posterior wall into the piriform sinus, filling it completely and infiltrating the larynx laterally. Then sterile washing and draping and creation of an apron flap in the usual manner. Start with the neck dissection on the right side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and the submandibular gland. Then locate the accessorius nerve and clear levels II b, III, IV and V while sparing the plexus branches. Exposure of the hypoglossal nerve and evacuation of the medial upper neck preparation. Then evacuation of the neck level VI and separate insertion of the neck level VI. Then turn to the opposite side and perform the neck dissection on the left side in the same way. Several large, coarse metastases are visible on the right side. On the left side only unspecifically enlarged lymph nodes. Then detachment of the cervical vascular sheath from the tumor and from the larynx. Detachment of the tumor from the spinal column. This is achieved without any problems using blunt dissection. Perform a median pharyngotomy at the level of the epiglottis. Then grasp the epiglottis and pull the epiglottis through the pharyngotomy. Carefully incise the mucosa along the aryepiglottic fold, first on the left side, then on the right side, observing the tumor margins. Release the laryngeal preparation in the posterior part. Then perform the tracheotomy. Enter the trachea between the 1st and 2nd tracheal cartilage. The patient has had a history of thyroidectomy, so that no thyroid gland was present. Suturing of the lower skin to the trachea. Then placement of a feeding tube under visualization. Locate the esophagus and remove the laryngeal specimen and the tumor specimen. An approx. 3 cm wide strip of mucosa remains in the upper part of the pharynx, but this becomes significantly smaller in the lower area, so that primary closure of the pharynx does not appear possible and the decision is therefore made to sew in a radialis graft in any case. In the meantime, suture marks are placed on the tumor specimen and the entire specimen is guided to the frozen section. Unfortunately, resection is necessary in 2 places, once in the area of the epiglottis and then at the caudal edge of the deposit. This is done by taking a resection specimen, which goes to the final histology and then new frozen sections. Both new frozen sections are tumor-free, so that an R0 situation can be confirmed intraoperatively. Therefore, lifting of the radialis graft and insertion of the graft as well as anastomosis of the vessels by . Parallel removal of the split skin from the right thigh and suturing of the split skin to the forearm. Application of a Mepilex dressing. Fixation of the Mepilex dressing with Mersilene sutures. Application of a Kramer splint. Completion of the operation without complications. : Now removal of the forearm flap from the left forearm: After measuring the defect, the flap dimensions are 13 to 14 cm in length and at least 8 to 9 cm in width. Record the flap with a skin monitor on the left forearm. Then first cut around the flap ulnarly. Dissect the skin, leaving subcutaneous tissue in the area of the planned subcutaneous bridge to the skin monitor, which is cut around. Continue the incision into the crook of the elbow. The flap is lifted ulnarly subfascially while preserving the ulnar artery. Then, after locating the superficial venous system and including it in the flap pedicle, lift the flap subfascially from the radial side. Locate the vascular pedicle under the brachioradialis muscle and follow it to the elbow. Locate the radial artery caudally and clamp. First lift the flap from the radial subfascial. Subsequently, the radial artery is removed. This is treated distally and proximally with 4-0 Prolene sutures. Lift the flap subfascially along the flap pedicle, taking the subcutaneous tissue with it to the skin monitor. Individual vessels are bipolarly coagulated or clipped. In the antecubital region, visualization of the radial artery of the confluence with the brachial artery and the outlet of the interosseous artery. Subsequent exposure of the cephalic vein, which splits into 2 vein ends, with connection to the deep vein system. The radial artery splits into smaller veins in the area of the confluence, which is not suitable for anastomosis and is separated and supplied with a clip. Another caudal vein, which arises from the subcutaneous tissue of the skin monitor, can initially be retained. The flap is removed. Veins are ligated. The artery is treated with 6-0 Vascufil sutures. Flush the flap with heparin solution. Subsequent insertion of the flap: First myotomy laterally to facilitate passage of food later. Subsequent suturing of the flap successively with Vicryl 3-0 single button sutures to the remaining mucosal bridge in the case of a subtotal pharyngeal defect. Defect extends to the palatal arch in the area of the uvula. Flap suturing is successful at all points without tension. Partial duplication of the suture to secure it. Subsequent conditioning of the vessels. The radial artery is anastomosed with the lingual artery using 8-0 single Ethilon button sutures. After opening the clamp, good arterial flow and good venous return. An outlet of the cephalic vein is then conditioned and anastomosed with the facial vein using a 3.0 coupler. Here too, after opening the clamp, good venous flow. Positive smear phenomenon. The other end is anastomosed with the external jugular vein using a 2.5 mm coupler; here too, good flow conditions after opening the clamp. Positive smear phenomenon. Then careful hemostasis. Irrigation of the entire wound area. Repositioning of the apron flap. Suture the apron flap to the trachea without tension. The skin monitor is integrated into the skin on the right side with a right-sided vascular connection. Redon drains were inserted on both sides, guided on the right. Finally, insertion of a size 10 tracheal cannula, which is fixed with sutures. The site for Doppler control is marked on the right side in the area of the external jugular vein. The procedure is completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue antibiotics for 2 to 3 days, which were started intraoperatively with clindamycin. Feeding via the PEG tube for at least 10 days, then gruel and, if necessary, diet build-up. Provox was not applied intraoperatively due to the flap situation and can still be applied at intervals. Please check the flap via skin monitor and Doppler sonography according to the scheme. Continue heparin perfusor 500 units per hour for 5 days. Overall cT4a cN2/4b oropharyngeal/hypopharyngeal/laryngeal carcinoma on the right. Postoperative radiochemotherapy should certainly be discussed. \ No newline at end of file diff --git a/725/InvasionFront_CD3_block22_x5_y6_patient725_0.json b/725/InvasionFront_CD3_block22_x5_y6_patient725_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2db27500f892ee506f01a9f1744ea975e5872700 --- /dev/null +++ b/725/InvasionFront_CD3_block22_x5_y6_patient725_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 26660.9, + "Num Detections": 25201, + "Num Negative": 25033, + "Num Positive": 168, + "Positive %": 0.6666, + "Num Positive per mm^2": 64.78 + } +} \ No newline at end of file diff --git a/725/InvasionFront_CD3_block22_x6_y6_patient725_1.json b/725/InvasionFront_CD3_block22_x6_y6_patient725_1.json new file mode 100644 index 0000000000000000000000000000000000000000..34565b7b26cf75f6c72cb0dbd821b41aa8686ec9 --- /dev/null +++ b/725/InvasionFront_CD3_block22_x6_y6_patient725_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19714.6, + "Centroid Y µm": 26685.9, + "Num Detections": 25830, + "Num Negative": 25727, + "Num Positive": 103, + "Positive %": 0.3988, + "Num Positive per mm^2": 38.82 + } +} \ No newline at end of file diff --git a/725/InvasionFront_CD8_block22_x5_y6_patient725_0.json b/725/InvasionFront_CD8_block22_x5_y6_patient725_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f4f517ccc959460fcb1c4a657d53f8783f2729df --- /dev/null +++ b/725/InvasionFront_CD8_block22_x5_y6_patient725_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19214.8, + "Centroid Y µm": 14817.2, + "Num Detections": 22554, + "Num Negative": 22414, + "Num Positive": 140, + "Positive %": 0.6207, + "Num Positive per mm^2": 56.23 + } +} \ No newline at end of file diff --git a/725/InvasionFront_CD8_block22_x6_y6_patient725_1.json b/725/InvasionFront_CD8_block22_x6_y6_patient725_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2f9ea6ccf87d300a1c3289ff79c26266b3cb7b03 --- /dev/null +++ b/725/InvasionFront_CD8_block22_x6_y6_patient725_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21838.4, + "Centroid Y µm": 14767.2, + "Num Detections": 24186, + "Num Negative": 24102, + "Num Positive": 84, + "Positive %": 0.3473, + "Num Positive per mm^2": 32.7 + } +} \ No newline at end of file diff --git a/725/TumorCenter_CD3_block22_x5_y6_patient725_0.json b/725/TumorCenter_CD3_block22_x5_y6_patient725_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0aa8fee8d48ab729cd2d468c72813399605fec4d --- /dev/null +++ b/725/TumorCenter_CD3_block22_x5_y6_patient725_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 15666.7, + "Num Detections": 29751, + "Num Negative": 29713, + "Num Positive": 38, + "Positive %": 0.1277, + "Num Positive per mm^2": 13.06 + } +} \ No newline at end of file diff --git a/725/TumorCenter_CD3_block22_x6_y6_patient725_1.json b/725/TumorCenter_CD3_block22_x6_y6_patient725_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d1d787acd6373e474a21977ee7baddda2ae383cf --- /dev/null +++ b/725/TumorCenter_CD3_block22_x6_y6_patient725_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19239.8, + "Centroid Y µm": 15716.7, + "Num Detections": 32293, + "Num Negative": 32284, + "Num Positive": 9, + "Positive %": 0.0279, + "Num Positive per mm^2": 3.08 + } +} \ No newline at end of file diff --git a/725/TumorCenter_CD8_block22_x5_y6_patient725_0.json b/725/TumorCenter_CD8_block22_x5_y6_patient725_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2c608c5094fb1a3e5a2f502206513085e8c49706 --- /dev/null +++ b/725/TumorCenter_CD8_block22_x5_y6_patient725_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 24986.8, + "Num Detections": 29454, + "Num Negative": 29333, + "Num Positive": 121, + "Positive %": 0.4108, + "Num Positive per mm^2": 41.69 + } +} \ No newline at end of file diff --git a/725/TumorCenter_CD8_block22_x6_y6_patient725_1.json b/725/TumorCenter_CD8_block22_x6_y6_patient725_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9e91b2efddb9f3d5efc02bb65a661eb218708ec3 --- /dev/null +++ b/725/TumorCenter_CD8_block22_x6_y6_patient725_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21513.6, + "Centroid Y µm": 25061.7, + "Num Detections": 30038, + "Num Negative": 30013, + "Num Positive": 25, + "Positive %": 0.0832, + "Num Positive per mm^2": 8.65 + } +} \ No newline at end of file diff --git a/725/history_text.txt b/725/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/725/icd_codes.txt b/725/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/725/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/725/ops_codes.txt b/725/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0894b902543af479dfba25854192ba7582926264 --- /dev/null +++ b/725/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme von Spalthaut an Oberschenkel und Knie[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Permanente Tracheotomie[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] \ No newline at end of file diff --git a/725/patient_clinical_data.json b/725/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce92a00124bdadb74e80f9b3d227412798b7fc1c --- /dev/null +++ b/725/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 59, + "adjuvant_treatment_intent": "palliative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/725/patient_pathological_data.json b/725/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cac9b687ecdfdcf827559428075038d656cd9f40 --- /dev/null +++ b/725/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "725", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/725/surgery_description.txt b/725/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..42340afa09a2fb94c9cb6723fd9711785191e032 --- /dev/null +++ b/725/surgery_description.txt @@ -0,0 +1 @@ +Total LE with partial pharyngectomy, Bilateral neck dissection, Defect coverage, Free flap (Radial), Provox prosthesis, PEG placement diff --git a/725/surgery_report.txt b/725/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4011181e9092f6924b94ede683b1ccb924ec980a --- /dev/null +++ b/725/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, the PEG is first placed by /: insertion with the gastroesophagoscope under air insufflation. Pre-insufflation into the stomach. After spontaneous diaphanoscopy, placement of a PEG tube with a thread pull-through method in the typical manner, no complications. The patient received 3 g Unacid i.v. perioperatively. Subsequently, infiltration of the subsequent apron flap incision with local anesthetic containing adrenaline. Sterile washing and draping. Marking and incision of the apron flap, which is lifted subplatysmal to the hyoid bone and fixed cranially in the usual manner. Then start with the right side. After identifying and opening the cervical vascular nerve sheath, regions II to V are successively removed. All non-lymphatic structures of the accessorius nerve, hypoglossal nerve and vagus nerve are spared and preserved. After evacuation of levels II to V and skeletonization of the carotid artery, the supralaryngeal vascular nerve bundle is severed. The insertions of the pharyngeal muscles are then separated from the lateral thyroid cartilage and the piriform sinus is released. Prior to this, the right thyroid lobe is ligated in the area of the isthmus and dislocated to the side. This also exposes the upper trachea. Then transition to the opposite side. In principle, a similar procedure is carried out here with the same findings. After separation of the pharyngeal muscles from the thyroid cartilage, the left piriform sinus is not released. The hyoid is then detached from the suprahyoid musculature with exposure of the pre-epiglottic fat body and preparation of the mucosa on the lingual epiglottis surface up to the upper edge of the epiglottis, without opening the pharynx first. The tracheostoma is then created. For this purpose, the 3rd tracheal clasp is cut caudally and the caudal mucocutaneous anastomosis is created. The patient is then reintubated without any problems. The 3rd tracheal clasp is then incised in an H-shape and the cartilage clasps are sutured to the side. Then transition to laryngectomy. For this, the larynx is first removed caudally under the cricoid. A caudally pedicled mucosal flap is then prepared, which will seal the tracheal chimney upwards towards Hermann. Removal of a marginal incision from the remaining endolaryngeal mucosal tissue from the specimen, which proves to be tumor-free on frozen section histology. Then dissection on the back of the cricoid cartilage down to the level of the arytenoid cartilage. Here then entry into the hypopharynx. After extending the incision on both sides, the tumor on the left side is visible. This shows that the first incision was made somewhat close to the tumor, so that an additional strip of mucosa is removed. The incision is then made on the right side along the epiglottis, leaving out the piriform sinus. On the tumor-bearing side, the tumor is cut around with an appropriate macroscopic safety distance of 1-11/2 cm and then joined in the area of the upper epiglottis edge or vallecula during the incision so that the larynx can be removed together with the pharyngeal part. Subsequently, circular marginal incisions are made from the pharyngeal defect. Dysplasia that does not correspond to CIS is still found in the area of the left hypopharynx. Nevertheless, resections are performed on this side and a new frozen section histological examination of the margin is performed, which then proves to be free of tumor and dysplasia. The defect measures approximately 9 cm in length and 6 cm in width. then lifts the corresponding radial lobe in this size. Then remove the radial forearm flap on the left (/PJ): Palpatory identification of the distal radial artery. Draw the flap boundaries 10 x 6 cm in the distal forearm proximal to the retina colum flexorum with an S-shaped course. Cut proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein. Dissection of the vein distally and with integration into the radial flap graft edge. Identification of the external ramus of the radial nerve and elevation of the radial portion while leaving the tissue of the brachioradialis muscle intact. Then incision down to the tendon of the flexor carpi radialis muscle, taking care to leave the peritendineum on the flexor tendons and to spare the ulnar nerve. Now identify the distal radialis and clamp it with a vascular clamp. After 5 minutes under good oxygen saturation measured by pulse oximetry on the thumb, the vessels are removed with subsequent ointment thread ligation after the pedicle has already been detached from the base, namely from the pronator quadratus and flexus policis longus muscles. Bipolar coagulation of the outgoing perforators and treatment with vascular clips into the cubital fossa. Exposure and sparing of the radial nerve in the median side of the brachioradialis muscle. Exposure of the ulnar and brachial arteries. The median cubital vein and the cephalic vein are also included, so that there are now 2 veins for anastomosis and the radial artery with an appropriate diameter is also removed proximally and treated with a lateral ligature. Hemostasis, two-layer wound closure in the area of the proximal forearm and distal graft bed with split skin from the right thigh in the usual manner. The split skin was previously lifted by . Application of a wound dressing and forearm splint. Subsequent suturing of the caudally pedicled mucosal flap on the tracheal chimney according to Hermann. Subsequently, myotomy of the constricotr pharyngis muscle and implantation of the Provox-Riga voice prosthesis. After removal of the radial lobe graft, it is sutured into the defect with single button sutures. The vascular pedicle is guided to the left side. The vessels or the branches of the external carotid artery up to the facial artery are extremely weak in caliber with a strong radial artery. For this reason, the maxillary artery is shown close to the external carotid artery and, after cutting through the digastric muscle, is followed as far as possible to the cranial side. Once there, it is displaced caudally together with the external carotid artery under the dissected hypoglossal nerve and anastomosed with the radial artery, which has approximately the same diameter. After the arterial anastomosis, the two venous anastomoses are made in an end-to-side manner to the internal jugular vein. A Redond suction drain is then placed on both sides and a drainage flap on the left side. Folding down of the apron flap and multi-layer wound closure with subsequent completion of the mucocutaneous anastomosis and reintubation of the patient onto a 10-gauge tracheostomy tube, which is fixed to the skin with 2 sutures. Sterile wound dressing. End of the operation, transfer of the patient to anesthesia. Conclusion: Total laryngectomy with partial pharyngectomy and defect coverage with a microvascular anastomosed radial lobe graft from the left forearm with simultaneous primary voice rehabilitation by implantation of a Provox-Riga voice prosthesis and myotomy of the constrictor pharyngis muscle due to a cT3 sinus piriformis carcinoma on the left side. \ No newline at end of file diff --git a/726/InvasionFront_CD3_block20_x3_y1_patient726_0.json b/726/InvasionFront_CD3_block20_x3_y1_patient726_0.json new file mode 100644 index 0000000000000000000000000000000000000000..83a88ed614024c4dbbfeca03b7f37e771d258465 --- /dev/null +++ b/726/InvasionFront_CD3_block20_x3_y1_patient726_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13291.1, + "Centroid Y µm": 2753.2, + "Num Detections": 31495, + "Num Negative": 31379, + "Num Positive": 116, + "Positive %": 0.3683, + "Num Positive per mm^2": 38.93 + } +} \ No newline at end of file diff --git a/726/InvasionFront_CD3_block20_x4_y1_patient726_1.json b/726/InvasionFront_CD3_block20_x4_y1_patient726_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9d03d505acdd8adb7ffaa7193b6d146aa5d4a2b --- /dev/null +++ b/726/InvasionFront_CD3_block20_x4_y1_patient726_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15794.2, + "Centroid Y µm": 2987.2, + "Num Detections": 28598, + "Num Negative": 28157, + "Num Positive": 441, + "Positive %": 1.542, + "Num Positive per mm^2": 150.1 + } +} \ No newline at end of file diff --git a/726/InvasionFront_CD8_block20_x3_y1_patient726_0.json b/726/InvasionFront_CD8_block20_x3_y1_patient726_0.json new file mode 100644 index 0000000000000000000000000000000000000000..62a82150aa2c161973aedcee32795a80656e55e2 --- /dev/null +++ b/726/InvasionFront_CD8_block20_x3_y1_patient726_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 2798.5, + "Num Detections": 31853, + "Num Negative": 31821, + "Num Positive": 32, + "Positive %": 0.1005, + "Num Positive per mm^2": 10.78 + } +} \ No newline at end of file diff --git a/726/InvasionFront_CD8_block20_x4_y1_patient726_1.json b/726/InvasionFront_CD8_block20_x4_y1_patient726_1.json new file mode 100644 index 0000000000000000000000000000000000000000..568cfc65988ede328426191266b7318dfa855530 --- /dev/null +++ b/726/InvasionFront_CD8_block20_x4_y1_patient726_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 2748.5, + "Num Detections": 30275, + "Num Negative": 30182, + "Num Positive": 93, + "Positive %": 0.3072, + "Num Positive per mm^2": 31.19 + } +} \ No newline at end of file diff --git a/726/TumorCenter_CD3_block20_x3_y1_patient726_0.json b/726/TumorCenter_CD3_block20_x3_y1_patient726_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c859562623528ebfd238171e915093dd851c5b39 --- /dev/null +++ b/726/TumorCenter_CD3_block20_x3_y1_patient726_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11314.6, + "Centroid Y µm": 2369.6, + "Num Detections": 27929, + "Num Negative": 27754, + "Num Positive": 175, + "Positive %": 0.6266, + "Num Positive per mm^2": 62.02 + } +} \ No newline at end of file diff --git a/726/TumorCenter_CD3_block20_x4_y1_patient726_1.json b/726/TumorCenter_CD3_block20_x4_y1_patient726_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10f1fc22e6d4a445e1e90b1ca2567dfbc610746a --- /dev/null +++ b/726/TumorCenter_CD3_block20_x4_y1_patient726_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13885.5, + "Centroid Y µm": 2486.9, + "Num Detections": 20518, + "Num Negative": 20216, + "Num Positive": 302, + "Positive %": 1.472, + "Num Positive per mm^2": 148.52 + } +} \ No newline at end of file diff --git a/726/TumorCenter_CD8_block20_x3_y1_patient726_0.json b/726/TumorCenter_CD8_block20_x3_y1_patient726_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c808fc47bfbbdfa3aa428dfa4b4e17a96e907925 --- /dev/null +++ b/726/TumorCenter_CD8_block20_x3_y1_patient726_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10219.6, + "Centroid Y µm": 2698.6, + "Num Detections": 29218, + "Num Negative": 29153, + "Num Positive": 65, + "Positive %": 0.2225, + "Num Positive per mm^2": 22.6 + } +} \ No newline at end of file diff --git a/726/TumorCenter_CD8_block20_x4_y1_patient726_1.json b/726/TumorCenter_CD8_block20_x4_y1_patient726_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06d8d50b0be83760c84fd8fec6cdae0414c0c27d --- /dev/null +++ b/726/TumorCenter_CD8_block20_x4_y1_patient726_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12793.2, + "Centroid Y µm": 2673.6, + "Num Detections": 30098, + "Num Negative": 29915, + "Num Positive": 183, + "Positive %": 0.608, + "Num Positive per mm^2": 63.56 + } +} \ No newline at end of file diff --git a/726/history_text.txt b/726/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/726/icd_codes.txt b/726/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..14192cbe1a6b6528ed0560e824c7e3bf1759711c --- /dev/null +++ b/726/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] Supraglottisches Karzinom[C32.1 ] \ No newline at end of file diff --git a/726/ops_codes.txt b/726/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..54016fbfed5cb09b8194c4727dc93477c4d57508 --- /dev/null +++ b/726/ops_codes.txt @@ -0,0 +1 @@ +Selektive Neck dissection in 3 Regionen[5-403.02 B] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Endoskopische Laserresektion Larynxgewebe[5-302.5 ] Tracheotomie inferior[5-311.x ] \ No newline at end of file diff --git a/726/patient_clinical_data.json b/726/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d983eaad88ee1c596a01a1a58368ae3257660311 --- /dev/null +++ b/726/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 46, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/726/patient_pathological_data.json b/726/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b41fb8d01229bfc7d87bb2e9885b084e4ff51d41 --- /dev/null +++ b/726/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "726", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/726/surgery_description.txt b/726/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1ab71e8c91381e0082d017b5babb90a0176e1fc --- /dev/null +++ b/726/surgery_description.txt @@ -0,0 +1 @@ +Transoral laser resection, Modified radical neck dissection, PEG, Tracheotomy diff --git a/726/surgery_report.txt b/726/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2612a2d9db0b1d8d231a1ddb35d10c9299e38760 --- /dev/null +++ b/726/surgery_report.txt @@ -0,0 +1 @@ +Dictation : Induction of anesthesia by anesthesia, intubation by anesthesia. Entering with the flexible esophagoscope. Advance into the stomach. No abnormalities here. With good diaphanoscopy, insertion of a PEG tube using the thread pull-through method. This is successful without any problems. Repositioning and insertion with the small water tube. Inspection of the hypopharynx, larynx and supraglottis. No abnormalities in the pharynx. Adjustment of the tumor region. There is an exophytic tumor on the lingual epiglottis surface, which occupies two thirds of the epiglottis, merges with the aryepiglottic fold, does not touch the arytenoid cartilage itself, but extends to just before the arytenoid cartilage. The pocket fold and glottic plane are completely inconspicuous. Switching the laser on and starting the laser resection with 3.5 W. The epiglottis is split laterally on the left. The suprahyal parts of the epiglottis are then removed using the piecemeal technique and the tumor is successively resected. The aryepiglottic fold is removed up to the arytenoid cartilage. The vallecula is partially resected and a small piece of the base of the tongue is also removed due to the safety margin. The entire specimen is thread-marked on cork with colored needles and sent to the pathology department. Removal of marginal samples. The marginal samples are all tumor-free in the frozen section. Therefore R0 situation. Demonstration of the findings of the defect to . The latter recommends a tracheostomy. This is performed by and . Repositioning for neck dissection. Skin incision in a preformed skin fold, initially on the right side, transverse. Exposure of the platysma. Dissection of the platysma cranially and caudally. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the cervical vascular sheath. Removal of neck levels II, III and IV while sparing the plexus branches and sparing the hypoglossal nerve, accessorius nerve, facial vein and superior thyroid artery. Sparing of the cervical artery. The neck levels must be sent in individually due to the study protocol. This is done fixed in formalin. Turn to the opposite side. Here also skin incision in a transverse preformed skin fold. Exposure of the platysma. Dissection of the platysmal flap. Dissection of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the submandibular gland and removal of the neck levels II to IV. Protection of the plexus branches and the accessory nerve, the facial vein and artery, the superior thyroid artery, the cervical artery and the hypoglossus. The neck levels are also sent in individually according to the study protocol and fixed in formalin. Dictation : Tracheotomy: palpation of the cricoid cartilage, marking of the incision, cutaneous incision, preparation of the subcutaneous tissue. Exposure of 2 lateral thyroid veins, ligation of the same. Splitting of the linea alba, undermining of the thyroid isthmus, repositioning and transection of the thyroid isthmus. Exploration of the cricoid cartilage, dissection of the anterior wall of the trachea. Locate the area between the 2nd and 3rd cricoid cartilage. Careful incision. Entry into the trachea. Creation of a visor tracheotomy. Transfer intubation to a 9 mm tracheal cannula. Dressing application. Completion of the procedure. Note: Supraglottic laser resection of a cT2 glottic carcinoma using the described piecemeal technique (two parts) which are placed on cork and marked for pathology. The patient is a study patient of the study. Please present postoperatively on day 8 in the phoniatrics department for functional swallowing endoscopy according to the study protocol. Presentation of the patient in the tumor conference. If adjuvant therapy becomes necessary, this must be carried out according to the study protocol in : Marking of the landmarks after sterile abjoration and covering. Skin incision and dissection through the subcutaneous fatty tissue. Locate the cephalic vein and dissect it distally. Finding the venous confluence in depth. Dissection of the 2 superficial veins into the antecubital fossa. Finding the pedicle between the bellies of the brachioradialis muscle and the flexor carpi radialis. The confluence is very small with a thickness of about 1 mm, but it can be preserved. Several other veins and connectors are also very small and delicate and can all be preserved. Exposure of the pedicle between the muscle bellies. Exposure of the radial artery at the junction between the brachial and ulnar arteries. Now mark the ulnar borders. The flap is lifted 12 x 6 or 3 cm wide. Ulnar incision and elevation of the myofascial flap up to the tendon of the flexor carpi radialis. Further incision and lifting of the graft with involvement of the cephalic vein. Protect the superficial ramus of the radial nerve. The ulnar artery on the opposite side can also be spared without any problems. Locate the radial artery distally and mark it with a silk thread. To prevent shearing, the fascia is sutured to the skin with 4-0 Vicryl. Now continue to successively dissect the flap, incorporating the pedicle. Lifting the flap and separating the vessels. Stitching over exposed tendons, removal of split skin. Suturing of split skin and two-layer wound closure in the usual manner. Creation of pie crusts and application of a sterile plaster cast. Neck dissection on the right by : Incision of the skin on the anterior edge of the sternocleidomastoid muscle (2 transverse fingers below the mandible extending mediocaudally). Separation of the subcutaneous tissue and the platysma. Subplatysmal dissection anteriorly and posteriorly. Identification of the omohyoid muscle. Dissection along the muscle up to the level of the hyoid bone. Now also identify the anterior edge of the sternocleidomastoid muscle and dissect down to the deep cervical fascia. Care is taken to preserve the branches of the cervical plexus. Identification of the accessorius nerve and release of the nerve from the cranial neck preparation. The digastric muscle is exposed in depth. Dissection along the muscle up to the level of the hyoid bone. Now free the neck preparation from the cervical vascular nerve sheath while protecting the nervous and vascular structures. No abnormalities on dissection. Some slightly more prominent lymph nodes in region II. Now remove the neck specimen in the usual way from cranial to caudal while protecting the deep plexus branches and the accessorius nerve. Wound irrigation and insertion of a 10-gauge Redon drain after extensive bipolar hemostasis. Two-layer wound closure after and completion of the right neck dissection without complications. Neck dissection on the left by : Incision of the skin on the anterior edge of the sternocleidomastoid muscle (2 transverse fingers below the mandible extending mediocaudally). Separation of the subcutaneous tissue and the platysma. Subplatysmal dissection anteriorly and posteriorly. Identification of the omohyoid muscle. Dissection along the muscle up to the level of the hyoid bone. Now also identify the anterior edge of the sternocleidomastoid muscle and dissect down to the deep cervical fascia. Care is taken to preserve the branches of the cervical plexus. Identification of the accessorius nerve and release of the nerve from the cranial neck preparation. The digastric muscle is exposed in depth. Dissection along the muscle up to the level of the hyoid bone. The neck preparation is then freed from the cervical vascular nerve sheath while sparing the nerve and vascular structures. A somewhat larger, metastasis-suspicious mass is located on the accessorius nerve, which can be easily separated from the nerve during preparation. No evidence of nerve infiltration. In region II, isolated somewhat more prominent lymph nodes. Now remove the neck specimen in the usual way from cranial to caudal, sparing the deep plexus branches and the accessorius nerve. Wound irrigation and insertion of a 10-gauge Redon drain after extensive bipolar hemostasis. Two-layer wound closure after and completion of the left neck dissection without complications. After continuation of the operation and removal of the radial lobe graft, it is sutured in the palatal area and doubled in the middle section. The stalk is drained into the right side of the neck via a corridor. There the arterial anastomosis is made to the superior thyroid artery and the venous anastomosis in the form of a two-end-to-side anastomosis directly to the internal jugular vein. Finally, insertion of a Redon suction drain in both sides and an additional flap in the right side of the neck near the anastomosis. The patient was subsequently reintubated onto an 8-gauge tracheostomy tube without any problems. End of the operation. Handover of the patient to anesthesia. Conclusion: Resection of a palatal carcinoma affecting the entire soft palate with microvascular reconstruction of a radial flap graft from the left forearm and defect coverage on the left forearm with split skin from the right thigh. In addition, selective neck dissection on both sides and creation of a plastic tracheostoma. \ No newline at end of file diff --git a/728/InvasionFront_CD3_block2_x3_y3_patient728_0.json b/728/InvasionFront_CD3_block2_x3_y3_patient728_0.json new file mode 100644 index 0000000000000000000000000000000000000000..520ef9ff590cb290d422cc89e34d6e8b5a677589 --- /dev/null +++ b/728/InvasionFront_CD3_block2_x3_y3_patient728_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 21038.9, + "Num Detections": 21258, + "Num Negative": 19907, + "Num Positive": 1351, + "Positive %": 6.355, + "Num Positive per mm^2": 590.84 + } +} \ No newline at end of file diff --git a/728/InvasionFront_CD3_block2_x4_y3_patient728_1.json b/728/InvasionFront_CD3_block2_x4_y3_patient728_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c0e28c84ac3d2651b833b51b4cd85109056e75fe --- /dev/null +++ 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"Positive %": 2.935, + "Num Positive per mm^2": 204.68 + } +} \ No newline at end of file diff --git a/728/TumorCenter_CD3_block2_x4_y3_patient728_1.json b/728/TumorCenter_CD3_block2_x4_y3_patient728_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7484acf2f678e1da55bcef2d05a516c023fb220c --- /dev/null +++ b/728/TumorCenter_CD3_block2_x4_y3_patient728_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 7346.1, + "Num Detections": 19270, + "Num Negative": 18374, + "Num Positive": 896, + "Positive %": 4.65, + "Num Positive per mm^2": 411.67 + } +} \ No newline at end of file diff --git a/728/TumorCenter_CD8_block2_x3_y3_patient728_0.json b/728/TumorCenter_CD8_block2_x3_y3_patient728_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d16d1627e4ae427861581e38a1d157a3ffe9e76c --- /dev/null +++ b/728/TumorCenter_CD8_block2_x3_y3_patient728_0.json @@ -0,0 +1,11 @@ +{ + 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b/728/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung der Uvula[D37.0 ] \ No newline at end of file diff --git a/728/patient_clinical_data.json b/728/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9f5d64c347114f2e02290f8dc7afbcf819a4777c --- /dev/null +++ b/728/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/728/patient_pathological_data.json b/728/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f4452ce5e886d8eb104a178d32026cf39b62e32a --- /dev/null +++ b/728/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "728", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/729/InvasionFront_CD3_block5_x5_y9_patient729_0.json b/729/InvasionFront_CD3_block5_x5_y9_patient729_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b60894443887346d86dadf7b9c30bb0c7f98d7c6 --- /dev/null +++ b/729/InvasionFront_CD3_block5_x5_y9_patient729_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 22962.8, + "Num Detections": 24071, + "Num Negative": 22084, + "Num Positive": 1987, + "Positive %": 8.255, + "Num Positive per mm^2": 711.38 + } +} \ No newline at end of file diff --git a/729/InvasionFront_CD3_block5_x6_y9_patient729_1.json b/729/InvasionFront_CD3_block5_x6_y9_patient729_1.json new file mode 100644 index 0000000000000000000000000000000000000000..459430b0f1f4728c9d1dd615a6af8e6cb773c0e9 --- /dev/null +++ b/729/InvasionFront_CD3_block5_x6_y9_patient729_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 22987.8, + "Num Detections": 26916, + "Num Negative": 25838, + "Num Positive": 1078, + "Positive %": 4.005, + "Num Positive per mm^2": 381.29 + } +} \ No newline at end of file diff --git a/729/InvasionFront_CD8_block5_x5_y7_patient729_0.json b/729/InvasionFront_CD8_block5_x5_y7_patient729_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e673fdcbde0db04161cd57c521940fcde3c51d9a --- /dev/null +++ b/729/InvasionFront_CD8_block5_x5_y7_patient729_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 17615.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/729/TumorCenter_CD3_block5_x5_y7_patient729_0.json b/729/TumorCenter_CD3_block5_x5_y7_patient729_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6d784d7b7c8858c9b6cb0edd4e7d47e7696d4494 --- /dev/null +++ b/729/TumorCenter_CD3_block5_x5_y7_patient729_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 17990.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/729/TumorCenter_CD3_block5_x6_y7_patient729_1.json b/729/TumorCenter_CD3_block5_x6_y7_patient729_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3d2016564b5f78b5cba94fa32b9b94b67b0969d --- /dev/null +++ b/729/TumorCenter_CD3_block5_x6_y7_patient729_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19414.7, + "Centroid Y µm": 18215.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/729/TumorCenter_CD8_block5_x6_y7_patient729_1.json b/729/TumorCenter_CD8_block5_x6_y7_patient729_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c91a7bbe38d2010e52484738fa18ff813a3dcf7 --- /dev/null +++ b/729/TumorCenter_CD8_block5_x6_y7_patient729_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 17515.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/729/patient_clinical_data.json b/729/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d2a476008c33fb47646b9b06d11baf98fd683773 --- /dev/null +++ b/729/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/729/patient_pathological_data.json b/729/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1864d7cc532cfa5deb07a696a82cff91d2bb3dd9 --- /dev/null +++ b/729/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "729", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/732/surgery_description.txt b/732/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9e856c0a82b0bf75a65c8fbd796125a758749ab2 --- /dev/null +++ b/732/surgery_description.txt @@ -0,0 +1 @@ +TORS resection, Bilateral neck dissection, Free flap (Radial) diff --git a/733/history_text.txt b/733/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/733/icd_codes.txt b/733/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/733/ops_codes.txt b/733/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/733/patient_clinical_data.json b/733/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e250262afa44577d5b244aa2aac165ea03d8be9e --- /dev/null +++ b/733/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2006, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/733/patient_pathological_data.json b/733/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f92e26468b31592e2288647eafac2bbcd57c85b3 --- /dev/null +++ b/733/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "733", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/733/surgery_description.txt b/733/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2cdfd2c0c462bb24e10269267749b8ce09f39023 --- /dev/null +++ b/733/surgery_description.txt @@ -0,0 +1 @@ +Tongue partial resection, Neck dissection, Panendoscopy, PEG placement diff --git a/733/surgery_report.txt b/733/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/734/InvasionFront_CD8_block4_x5_y7_patient734_0.json b/734/InvasionFront_CD8_block4_x5_y7_patient734_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2a5b50e946dafa50ec0bce09febd029b67ad5d8b --- /dev/null +++ b/734/InvasionFront_CD8_block4_x5_y7_patient734_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 22363.2, + "Num Detections": 24904, + "Num Negative": 17168, + "Num Positive": 7736, + "Positive %": 31.06, + "Num Positive per mm^2": 2884.6 + } +} \ No newline at end of file diff --git a/734/InvasionFront_CD8_block4_x6_y7_patient734_1.json b/734/InvasionFront_CD8_block4_x6_y7_patient734_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e4e6e2bbd85176275e7aca74d322b6c025454f3 --- /dev/null +++ b/734/InvasionFront_CD8_block4_x6_y7_patient734_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 22388.1, + "Num Detections": 24792, + "Num Negative": 16252, + "Num Positive": 8540, + "Positive %": 34.45, + "Num Positive per mm^2": 3117.6 + } +} \ No newline at end of file diff --git a/734/TumorCenter_CD8_block4_x5_y7_patient734_0.json b/734/TumorCenter_CD8_block4_x5_y7_patient734_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ed7f5d1715d8600cd1c98958fa37a82b5ff3db52 --- /dev/null +++ b/734/TumorCenter_CD8_block4_x5_y7_patient734_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16666.2, + "Centroid Y µm": 17990.5, + "Num Detections": 23880, + "Num Negative": 17394, + "Num Positive": 6486, + "Positive %": 27.16, + "Num Positive per mm^2": 2504.8 + } +} \ No newline at end of file diff --git a/734/TumorCenter_CD8_block4_x6_y7_patient734_1.json b/734/TumorCenter_CD8_block4_x6_y7_patient734_1.json new file mode 100644 index 0000000000000000000000000000000000000000..584a2777bfc7ce0d912021bf6f1e6843f3e1adcb --- /dev/null +++ b/734/TumorCenter_CD8_block4_x6_y7_patient734_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 18140.4, + "Num Detections": 24249, + "Num Negative": 15515, + "Num Positive": 8734, + "Positive %": 36.02, + "Num Positive per mm^2": 3376.3 + } +} \ No newline at end of file diff --git a/734/history_text.txt b/734/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..79d909cfca604705003ef6147ac58347d90eaf83 --- /dev/null +++ b/734/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed with cT2 cN2b cM0 oropharyngeal carcinoma on the right side. Panendoscopy with sampling in domo <2016> was performed. Histologically, a poorly differentiated basaloid carcinoma was strongly P16 positive. In our preoperative tumor conference <2016>, it was decided to perform an enoral resection with neck dissection on the right side. The patient had sufficient time to ask questions preoperatively and was informed in detail about the procedure. \ No newline at end of file diff --git a/734/icd_codes.txt b/734/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..14182db7c55df6b73533268ad1923e2ff0918719 --- /dev/null +++ b/734/icd_codes.txt @@ -0,0 +1 @@ +cT2 cN2b OropharynxCa rechts[C09.0 ] Karzinom Oropharynx Seitenwand[C10.2 R] \ No newline at end of file diff --git a/734/ops_codes.txt b/734/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..acb6deaf380f2fbbd2ddad2380a551601396138b --- /dev/null +++ b/734/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/734/patient_clinical_data.json b/734/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bd08b526772a15c3457f1c9676dd52547941efbf --- /dev/null +++ b/734/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 48, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/734/patient_pathological_data.json b/734/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c9fd7d7f5c322827bafa84566733c91e3c040e8d --- /dev/null +++ b/734/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "734", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/734/surgery_description.txt b/734/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..797aa44cddb73b7c600306539c9a335a99bcff45 --- /dev/null +++ b/734/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor tonsillectomy diff --git a/734/surgery_report.txt b/734/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..924b63e7b98f479ff2bb17a0064fac6d0e2d6b21 --- /dev/null +++ b/734/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating room and active implementation of the team time-out. Introductory consultation with anesthesia colleagues. Induction of intubation anesthesia by the colleagues. Positioning of the patient by the surgeon in the head reclination position. Inspection of the oropharynx begins with insertion of the McIvor mouth blocker. The tonsil on the right side is clearly prominent and hard to palpate. The tumor extends submucosally far into the soft palate on the right side. The medial tumor border is paramedian without crossing the midline. Caudally, the lower tonsil pole is tumor-free. There is no transition to the base of the tongue. Start tumor resection by marking the resection margins with the electric needle. Incision of the mucosa with the electric needle. Submucosal dissection with Cooper scissors. Smaller vessels are treated with the bipolar coagulation forceps. The tumor can be easily removed from the lateral oropharyngeal wall. The lower tonsil pole is free of tumor. Several marginal samples are taken for intraoperative frozen section diagnostics. It is shown that the cranial, medial and lateral margin samples of the tumor bed are still infiltrated by tumor. Decision to resect and resend the resected specimens for frozen section diagnostics. Here, too, tumor infiltration in the cranial and lateral areas of the tumor bed is noted. The findings are demonstrated to . Decision to perform a generous resection in the cranial part of the tumor with subtotal resection of the soft palate. Re-determination of several representative marginal samples. These are now tumor-free. An R0 situation can therefore be definitively assumed. After completion of the tumor resection, re-inspection of the wound area. The anterior palatal arch was completely resected. The posterior palatal arch was also completely used up. In addition, the tumor resection had to be performed cranially up to a subtotal resection of the soft palate. In the cranial part of the posterior palatal arch there is a defect approx. 1 x 1 cm to the nasopharynx. The lateral resection margin extends to the parapharyngeal fatty tissue. Due to the depth of the defect, a neck dissection on the right side is not performed in the same session in order to avoid an extensive defect. Hemostasis is performed using hydrogen and bipolar coagulation forceps. An attempt is made to reduce the defect with several adapting sutures. Bleeding is checked again at the end of the operation by raising the blood pressure. The wound bed is completely dry. During the frozen section break, a PEG tube was also inserted in the usual manner using the suture pull-through method. This was performed without complications. Conclusion: The enoral tumor resection of a cT2 cN2b oropharyngeal carcinoma on the right side was performed today. Due to the size and depth of the defect in relation to the lateral pharyngeal wall with exposed parapharyngeal fatty tissue, simultaneous neck dissection is not performed. This should be planned at least 3 weeks apart. Depending on how well the wound has healed by granulation by then, defect coverage using vascular-free microvascular flap plasty should be discussed at the same time. This should be performed to prevent regurgitation, particularly with regard to the functional results in the case of a pronounced defect in the soft palate. Please wait for the final histology and present the case again in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/735/InvasionFront_CD3_block15_x3_y2_patient735_0.json b/735/InvasionFront_CD3_block15_x3_y2_patient735_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad04df18dbe616e2395e71dcf154b9c18c504599 --- /dev/null +++ b/735/InvasionFront_CD3_block15_x3_y2_patient735_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12618.3, + "Centroid Y µm": 15067.0, + "Num Detections": 16582, + "Num Negative": 13072, + "Num Positive": 3510, + "Positive %": 21.17, + "Num Positive per mm^2": 1536.3 + } +} \ No newline at end of file diff --git a/735/InvasionFront_CD3_block15_x4_y2_patient735_1.json b/735/InvasionFront_CD3_block15_x4_y2_patient735_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7fc216b154203a9fd3c5785b542a0b77ffeff92f --- /dev/null +++ b/735/InvasionFront_CD3_block15_x4_y2_patient735_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15241.9, + "Centroid Y µm": 14867.1, + "Num Detections": 16889, + "Num Negative": 13797, + "Num Positive": 3092, + "Positive %": 18.31, + "Num Positive per mm^2": 1342.8 + } +} \ No newline at end of file diff --git a/735/InvasionFront_CD8_block15_x3_y2_patient735_0.json b/735/InvasionFront_CD8_block15_x3_y2_patient735_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0dfd02146d7eb5f42171b48bfe3a9d7b85fe465b --- /dev/null +++ b/735/InvasionFront_CD8_block15_x3_y2_patient735_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10961.1, + "Centroid Y µm": 4913.4, + "Num Detections": 14869, + "Num Negative": 12740, + "Num Positive": 2129, + "Positive %": 14.32, + "Num Positive per mm^2": 979.05 + } +} \ No newline at end of file diff --git a/735/InvasionFront_CD8_block15_x4_y2_patient735_1.json b/735/InvasionFront_CD8_block15_x4_y2_patient735_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d261e421f64d77e9c7ceb5c84e34342fd962773d --- /dev/null +++ b/735/InvasionFront_CD8_block15_x4_y2_patient735_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13564.4, + "Centroid Y µm": 4880.5, + "Num Detections": 14698, + "Num Negative": 12893, + "Num Positive": 1805, + "Positive %": 12.28, + "Num Positive per mm^2": 836.64 + } +} \ No newline at end of file diff --git a/735/TumorCenter_CD3_block15_x3_y2_patient735_0.json b/735/TumorCenter_CD3_block15_x3_y2_patient735_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b6a1f1ec1ccecefa92769773b726bb9760bd653 --- /dev/null +++ b/735/TumorCenter_CD3_block15_x3_y2_patient735_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 8295.6, + "Num Detections": 16893, + "Num Negative": 13857, + "Num Positive": 3036, + "Positive %": 17.97, + "Num Positive per mm^2": 1374.6 + } +} \ No newline at end of file diff --git a/735/TumorCenter_CD3_block15_x4_y2_patient735_1.json b/735/TumorCenter_CD3_block15_x4_y2_patient735_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b33e1b834dad86e05c9a4217461faf34b482194 --- /dev/null +++ b/735/TumorCenter_CD3_block15_x4_y2_patient735_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 8270.6, + "Num Detections": 17362, + "Num Negative": 14340, + "Num Positive": 3022, + "Positive %": 17.41, + "Num Positive per mm^2": 1373.5 + } +} \ No newline at end of file diff --git a/735/TumorCenter_CD8_block15_x3_y2_patient735_0.json b/735/TumorCenter_CD8_block15_x3_y2_patient735_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b127f39ac9af6ca6685f4c6c26001f694b710f6e --- /dev/null +++ b/735/TumorCenter_CD8_block15_x3_y2_patient735_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 5047.3, + "Num Detections": 16214, + "Num Negative": 14367, + "Num Positive": 1847, + "Positive %": 11.39, + "Num Positive per mm^2": 856.55 + } +} \ No newline at end of file diff --git a/735/TumorCenter_CD8_block15_x4_y2_patient735_1.json b/735/TumorCenter_CD8_block15_x4_y2_patient735_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ec9064e98fc36e3c687db4dae6b197cd7507ca4 --- /dev/null +++ b/735/TumorCenter_CD8_block15_x4_y2_patient735_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 4997.4, + "Num Detections": 15519, + "Num Negative": 13685, + "Num Positive": 1834, + "Positive %": 11.82, + "Num Positive per mm^2": 857.29 + } +} \ No newline at end of file diff --git a/735/history_text.txt b/735/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1066498ea1bbfc37671d3829623218f1dfc86f0 --- /dev/null +++ b/735/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the tongue on the right, therefore the above-mentioned operation is indicated. \ No newline at end of file diff --git a/735/icd_codes.txt b/735/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf422e8d9567fdb2464b75d4b6093c8a641ac4db --- /dev/null +++ b/735/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 R] \ No newline at end of file diff --git a/735/ops_codes.txt b/735/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ecc2a7e02e5ed3115ee7ff9812d339b2530c12d --- /dev/null +++ b/735/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Radikale Neck dissection in 5 Regionen[5-403.11 R] Selektive Neck dissection in 3 Regionen[5-403.02 L] Permanente Tracheotomie[5-312.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Diagnostische indirekte Oropharyngoskopie[1-611.1 ] Diagnostische indirekte Oropharyngoskopie[1-611.1 ] \ No newline at end of file diff --git a/735/patient_clinical_data.json b/735/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..071d3f216260f58c0a933ecf671756627e7b2d93 --- /dev/null +++ b/735/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/735/patient_pathological_data.json b/735/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..00cb6bb9f9a4a8a25fab8f66ed27f661a3ab2371 --- /dev/null +++ b/735/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "735", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 22.0 +} \ No newline at end of file diff --git a/735/surgery_description.txt b/735/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1bdd112c3e99fec47cb38b2e9d2e9e7be41dc49 --- /dev/null +++ b/735/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Defect coverage, Tracheotomy diff --git a/735/surgery_report.txt b/735/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ae5f13f19e8fa12b88067c185756a5143fc50615 --- /dev/null +++ b/735/surgery_report.txt @@ -0,0 +1 @@ +First, another oral cavity inspection and pharyngoscopy. The deeply ulcerated tumor on the left edge of the tongue is seen, which extends into the base of the tongue and runs towards the floor of the mouth and the lingual box. First transoral tumor resection: insertion of a retractor, placement of a tongue tie suture. Tumor is removed on all sides with a safety margin of 1.5 to 2 cm. The posterior 2/3 of the tongue including the base of the tongue, floor of the mouth including the lingual nerve and parts of the submandibular and sublingual glands as well as the tonsil and glossotonsillar junction are removed. The specimen is marked with a thread and sent for frozen section. No infiltrates in all margins in the frozen section, thus R0 situation. The lingual artery was ligated during the transoral resection. Careful hemostasis. Repositioning for neck dissection and tracheostomy. First radical neck dissection on the right: skin incision in typical manner. Exposure of the sternocleidomastoid and omohyoid muscles as well as the digastric muscle. Exposure of the internal jugular vein, external carotid artery. Large vessels can be dissected cranially from the lymph node conglomerate. Vagus nerve is exposed and preserved. Also the hypoglossal nerve. N. accessorius cannot be preserved and is resected together with the sternocleidomastoid muscle. Similarly, hardly any muscular structures can be preserved in the cranial part. The metastasis is infiltrated in muscular structures and in the cervical plexus. All branches infiltrated by the lymph node conglomerate are also resected, including the accessorius nerve. All deep cervical muscles and neck muscles are also resected, including the trapezius muscle. Caudally positive lymph nodes up to level V. Branches of the cervical plexus can be preserved in the caudal part. Evacuation level II to V. Due to the extensive lymph node metastasis, large areas of subcutaneous tissue below the nuchal and occipital skin as well as muscular tissue are removed. This is sent for frozen section. No more tumor infiltrates here. The submandibular gland is removed to create an enoral tunnel. The digastric and styloid muscles are severed. Remains of the lingual nerve are removed together with the gland. The lingual nerve had already fallen during the transoral tumor resection. The hypoglossal nerve can be preserved. Subsequent neck dissection on the left side: exposure of the sternocleidomastoid, omohyoid and digastric muscles. Exposure and preservation of the internal jugular vein, internal carotid artery, external carotid artery. Visualization of the superior thyroid artery and hypoglossal nerve, accessorius nerve and vagus nerve. Also visualization of the border cord. Evacuation level II to IV, followed by tracheostoma placement. Kocher's collar incision. Exposure of linea alba. Dissection of the infrahyoid musculature, visualization of the thyroid isthmus. This is passed underneath, clamped off, severed and supplied by means of puncture ligatures. Subsequent exposure of the trachea. In the 2nd/3rd intercartilaginous space, enter the trachea and create a wide pedicled modified Björk flap. This is epithelized in the typical manner. Re-intubation and creation of a Woodbridge tube. Subsequent removal of the forearm graft from the left: After measuring the size, which is 10-11 x 6-7 cm, the flap is marked in the corresponding orientation for the course of the pedicle. The flap is then lifted from the ulnar subfascial side, followed by an incision in the crook of the elbow. Expose the superficial venous system and connect to the deep venous system. Then expose the flap radially and lift subfascially. The lateral cutaneous ramus of the antibrachial cutaneous nerve is exposed and preserved. Distal exposure of the radial artery and accompanying veins. Initially clamp for a few minutes. Exposure of the pedicle along the brachioradialis muscle. Exposure and connection of the deep superficial venous system. A cephalic vein with 2 outlets can be visualized in the crook of the elbow. The radial artery and a relatively well preserved confluence can also be visualized. Then dissection of the radial artery distally. Saturation always at 100 %. Successive elevation of the flap subfascially. Smaller vessels are supplied bipolar or with clips. Lift up to the crook of the elbow. Exposure of the radial artery and venous outlets. Deposition of the flap on 2 outlets from the cephalic vein, which are ligated, as well as deposition on an outlet corresponding to the confluence and ligation here. The radial artery is removed, which is treated with a 6-0 Vascufil suture. The interosseous artery is also severed. Treatment with clips. After previous clamping, the hand was also always well perfused with saturation of 99-100%. The flap is then removed and flushed with heparin solution. A piece of split skin 0.8 mm thick is removed from the thigh. This is then treated with a hydrogel dressing. Split skin is worked into the defect. Complete defect coverage. Closure primarily cranially. Insertion of a Redon drain underneath. Subsequent hydrogel-Mepilex dressing. Cover with a cotton swab dressing. Wrapping in absorbent cotton. Fitting of a Cramer splint. This is fixed in a functional position with a tape bandage. Hand still with normal saturation when attached. Now suture the flap: After sutures have been placed, the flap is successively worked into the defect. The pedicle is passed caudally in between. The flap can be worked into the defect without tension. Complete functional closure of the defect. Subsequent anastomosis of the flap. Conditioning of the superior thyroid artery and the radial artery. Anastomosis with 9.0 Ethilon single-button sutures. After opening the clamp, good arterial flow and good venous return. The facial vein is then exposed with 2 outlets and conditioned. After conditioning, the larger outlet is anastomosed with the confluence with 3-0 coupler. After opening the clamps, good venous flow smear, positive phenomenon. Subsequently, before the outlets of the cephalic vein, the larger one is anastomosed with the second outlet from the facial vein, also with a 3-0 coupler. Again, good venous flow after opening the clamp. Positive smear phenomenon. The other outlet is closed or ligated. Subsequent careful hemostasis. Irrigation of the entire wound area. Wound closure on the left with insertion of 2 flaps. Wound closure on the right after careful hemostasis and irrigation with insertion of a Redon drain. Insertion of an 8-0 tracheostomy tube. Completion of the procedure without complications. Patient admitted to intensive care unit for postoperative monitoring. Please continue the intraoperative antibiotic treatment with Unacid for one week. Nutrition via the inserted PEG tube for 7-10 days. Then, if necessary, swallow gruel and build up diet. Please continue intraoperative therapy with heparin perfusor 500 E/hour for 5 days. Flap control clinically according to the scheme for 5 days. Overall cT2-3 squamous cell carcinoma of the tongue margin/base of tongue and glossotonsillar junction. Extensive lymph node infiltration in the soft tissue nuchal occipital right. Therefore radical neck dissection. Postoperative RCT certainly indicated. Presentation in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/736/InvasionFront_CD3_block3_x5_y1_patient736_0.json b/736/InvasionFront_CD3_block3_x5_y1_patient736_0.json new file mode 100644 index 0000000000000000000000000000000000000000..03650765cb20fcc4d9b6ea192f6dd98758f7027c --- /dev/null +++ b/736/InvasionFront_CD3_block3_x5_y1_patient736_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18890.0, + "Centroid Y µm": 7021.3, + "Num Detections": 21547, + "Num Negative": 19541, + "Num Positive": 2006, + "Positive %": 9.31, + "Num Positive per mm^2": 837.48 + } +} \ No newline at end of file diff --git a/736/InvasionFront_CD3_block3_x6_y1_patient736_1.json b/736/InvasionFront_CD3_block3_x6_y1_patient736_1.json new file mode 100644 index 0000000000000000000000000000000000000000..018320d2f1d542286ac51c17a1caa2e2a8a2b8dd --- /dev/null +++ b/736/InvasionFront_CD3_block3_x6_y1_patient736_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21613.6, + "Centroid Y µm": 7096.2, + "Num Detections": 22857, + "Num Negative": 19882, + "Num Positive": 2975, + "Positive %": 13.02, + "Num Positive per mm^2": 1275.6 + } +} \ No newline at end of file diff --git a/736/InvasionFront_CD8_block3_x5_y1_patient736_0.json b/736/InvasionFront_CD8_block3_x5_y1_patient736_0.json new file mode 100644 index 0000000000000000000000000000000000000000..47b7b4e956b257fb19c6b7604282511d101870dd --- /dev/null +++ b/736/InvasionFront_CD8_block3_x5_y1_patient736_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17344.9, + "Centroid Y µm": 2209.8, + "Num Detections": 19028, + "Num Negative": 17538, + "Num Positive": 1490, + "Positive %": 7.831, + "Num Positive per mm^2": 719.05 + } +} \ No newline at end of file diff --git a/736/InvasionFront_CD8_block3_x6_y1_patient736_1.json b/736/InvasionFront_CD8_block3_x6_y1_patient736_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cea705ca8a530f89f95d23f2dcdaee6a091e32e9 --- /dev/null +++ b/736/InvasionFront_CD8_block3_x6_y1_patient736_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19889.5, + "Centroid Y µm": 2123.9, + "Num Detections": 21560, + "Num Negative": 20231, + "Num Positive": 1329, + "Positive %": 6.164, + "Num Positive per mm^2": 588.85 + } +} \ No newline at end of file diff --git a/736/TumorCenter_CD3_block3_x5_y1_patient736_0.json b/736/TumorCenter_CD3_block3_x5_y1_patient736_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e5a19e4824ed7b24e511c4f52aeb4380d658f9c9 --- /dev/null +++ b/736/TumorCenter_CD3_block3_x5_y1_patient736_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16565.4, + "Centroid Y µm": 8431.5, + "Num Detections": 10238, + "Num Negative": 9539, + "Num Positive": 699, + "Positive %": 6.828, + "Num Positive per mm^2": 545.71 + } +} \ No newline at end of file diff --git a/736/TumorCenter_CD3_block3_x6_y1_patient736_1.json b/736/TumorCenter_CD3_block3_x6_y1_patient736_1.json new file mode 100644 index 0000000000000000000000000000000000000000..80e042d4a873fbc845fee6e9136d0d666c860c17 --- /dev/null +++ b/736/TumorCenter_CD3_block3_x6_y1_patient736_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18906.2, + "Centroid Y µm": 8451.8, + "Num Detections": 18443, + "Num Negative": 15404, + "Num Positive": 3039, + "Positive %": 16.48, + "Num Positive per mm^2": 1395.7 + } +} \ No newline at end of file diff --git a/736/TumorCenter_CD8_block3_x5_y1_patient736_0.json b/736/TumorCenter_CD8_block3_x5_y1_patient736_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fda2a18ba87aca643d23194b67563cd5e80dbe74 --- /dev/null +++ b/736/TumorCenter_CD8_block3_x5_y1_patient736_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17715.6, + "Centroid Y µm": 4647.5, + "Num Detections": 9221, + "Num Negative": 9070, + "Num Positive": 151, + "Positive %": 1.638, + "Num Positive per mm^2": 153.27 + } +} \ No newline at end of file diff --git a/736/TumorCenter_CD8_block3_x6_y1_patient736_1.json b/736/TumorCenter_CD8_block3_x6_y1_patient736_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a697c83cb18dfe635622720b4e31cb470753e447 --- /dev/null +++ b/736/TumorCenter_CD8_block3_x6_y1_patient736_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 4647.5, + "Num Detections": 19480, + "Num Negative": 18431, + "Num Positive": 1049, + "Positive %": 5.385, + "Num Positive per mm^2": 490.36 + } +} \ No newline at end of file diff --git a/736/history_text.txt b/736/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/736/icd_codes.txt b/736/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a9c90997f0b52b8a28631ba2371cc3e4150d3c13 --- /dev/null +++ b/736/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/736/ops_codes.txt b/736/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a81b07caf153be11d510086de60cf846d2bc3365 --- /dev/null +++ b/736/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] sonstige[5-296.0x ] Weichgaumenteilresektion[5-272.1 ] Sonstige partielle Glossektomie sonstige[5-251.xx ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion][5-295.xx ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 R] Selektive Neck dissection in 4 Regionen[5-403.03 L] Permanente Tracheotomie[5-312.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R] Spalthaut großflächig Empfängerstelle Hand[5-902.49 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme eines freien Lappens an der Hand mit mikrovaskulärer Anastomosierung[5-904.09 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/736/patient_clinical_data.json b/736/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bab1d1f04c7b73503fa79021e4f903bf098962e0 --- /dev/null +++ b/736/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/736/patient_pathological_data.json b/736/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..120c77c948db635585c155d4a6b9aeca9c5b48e2 --- /dev/null +++ b/736/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "736", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 6.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 42.0 +} \ No newline at end of file diff --git a/736/surgery_description.txt b/736/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..dfd8293a9896d5ff2cc3834dedb24bcb1413030c --- /dev/null +++ b/736/surgery_description.txt @@ -0,0 +1 @@ +Combined transoral trans-cervical tumor resection, Free flap (Radial) diff --git a/736/surgery_report.txt b/736/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..963d14b19be8ce333566619cc7eba3fb21fab3e2 --- /dev/null +++ b/736/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesiologist. Transnasal intubation by anesthesia colleagues. Sterile washing and draping. Start with transoral tumor resection. For this purpose, the tongue is snared and the tumor region is cut around with the monopolar needle in the area of the edge of the tongue to the base of the tongue. Then switch to the neck, as an overview is no longer guaranteed and the main tumor mass is located in the base of the tongue; instead, a skin incision is made in a transverse skin fold 3 transverse fingers below the lower jaw. Exposure of the platysma. Separation of the platysma. Dissection of the platysma cranially and caudally. Exposure of the submandibular gland, then the anterior margin of the sternocleidomastoid muscle, the omohyoid muscle, the cervical vascular sheath and the accessorius nerve. Levels II to V a are then dissected out, sparing the plexus branches. The submandibular gland is detached and the digastric muscle is cut. The tumor clearly bulges in the area of the floor of the mouth and level II and can also be palpated here. Except for the external jugular vein, all neck vessels can be preserved. Now tanscervical tumor resection. To do this, grasp the tumor and subcircumcise it. Perform a pharyngotomy and enter the oral cavity. Further tumor resection using the pull-through technique. This allows the tumor to be completely resected en bloc. In the area of the glossotonsillar groove and in the area of the edge of the tongue, the tumor is very narrowly resected macroscopically, so a generous resection is performed here and a marginal sample is taken. Unfortunately, the resected frozen section still showed invasive carcinoma in the area of the edge of the tongue. Due to an organizational oversight, the marginal sample from the edge of the tongue that was taken after the resection was unfortunately not included in the frozen section. Therefore, another resection is performed here and a marginal sample is taken, which is ultimately tumor-free, final R0 situation. Repositioning for neck dissection on the right side and tracheotomy. Tracheotomy dictation : Marking of the landmarks (thyroid incisura, cricoid cartilage and jugulum). Mark the skin incision approximately 0.5 cm below the cricoid cartilage. Now start the incision and cut through the subcutaneous fatty tissue. This is carefully bipolarized. Insert two sharp retractors and dissect through the entire subcutaneous fatty tissue. Dissection on the prelaryngeal musculature. The linea alba is sought out and dissection continues in this area. The prelaryngeal musculature is released in the middle and pushed bluntly to both sides. Locate the capsule of the thyroid gland. Here ligation of a vein. The thyroid gland is ligated and the remaining ends are bipolarized. There is hemostasis. Exposure of the trachea. The trachea is now opened between the second and third tracheal clips. The incision is extended further to the right and left. A Björk flap is not applied. Suture in the Mersilene sutures. With the Kilian speculum, reintubation is performed without any problems, so that an 8 mm tube is now used for ventilation during the operation. Neck dissection on the right. Skin incision three transverse fingers below the lower jaw in a skin fold. Exposure of the platysma and dissection and preparation of the platysma cranially and caudally. Exposure of the anterior border of the sternocleidomastoid muscle, the submandibular gland, the omohyoid muscle and the digastric muscle. Clearing out the neck levels II a to V a, while sparing the plexus branches. All vessels, including the external jugular vein, can be preserved. Lifting the radial artery graft. First palpate the radial artery and mark the graft 12 x 8 cm. Then unwrap the forearm and further dissection in bloodlessness. Cut around the graft in the skin area. Incision up to the crook of the elbow. Exposure of the brachioradialis muscle. Exposure of the venous star in the antecubital fossa. Exposure of the superficial ramus, radial nerve, which divides into two main branches. Both main branches can be preserved. Exposure of the radial artery. Clamping and severing of the radial artery. Ligation. Detachment of the graft from the tendons and release of the pedicle in the usual manner. Deposition of the radialis graft with a superficial and a deep vein. Suturing of the graft first from the transoral side, starting at the soft palate, then along the floor of the mouth. The graft must be attached to the teeth and the alveolar ridge, as there is not enough mucosal remnant in the rest of the floor of the mouth. Further suturing from transcervically in the area of the pharynx and the vallecula and finally reconstruction of the tongue with the remainder of the transoral graft. Repositioning to perform the vascular anastomosis. The radial artery is connected to the facial artery and a vein from the graft to the facial vein and another vein to a branch of the facial vein. Good graft perfusion at the end. Insertion of 2 Redon drains, one on the left, one on the right and two-layer wound closure on both sides. The patient is ventilated and admitted to the intensive care unit. Please continue antibiotic treatment for 24 hours postoperatively, then X-ray emesis on the 10th postoperative day and diet build-up if no fistula is present. Presentation of the patient for planning of adjuvant therapy after receipt of the histology. \ No newline at end of file diff --git a/737/InvasionFront_CD3_block1_x1_y10_patient737_0.json b/737/InvasionFront_CD3_block1_x1_y10_patient737_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bf09f9262bd779c1a529d4baa8c1bbf831ed9f0b --- /dev/null +++ b/737/InvasionFront_CD3_block1_x1_y10_patient737_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3473.2, + "Centroid Y µm": 26660.9, + "Num Detections": 28774, + "Num Negative": 27516, + "Num Positive": 1258, + "Positive %": 4.372, + "Num Positive per mm^2": 461.94 + } +} \ No newline at end of file diff --git a/737/InvasionFront_CD3_block1_x2_y10_patient737_1.json b/737/InvasionFront_CD3_block1_x2_y10_patient737_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9d9a5ef42b99a10b9589197a6c6afdb51c0b2aa5 --- /dev/null +++ b/737/InvasionFront_CD3_block1_x2_y10_patient737_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 26685.9, + "Num Detections": 29584, + "Num Negative": 28247, + "Num Positive": 1337, + "Positive %": 4.519, + "Num Positive per mm^2": 489.26 + } +} \ No newline at end of file diff --git a/737/InvasionFront_CD8_block1_x1_y10_patient737_0.json b/737/InvasionFront_CD8_block1_x1_y10_patient737_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d147f0921a2a870432615be29aa2269c26746fba --- /dev/null +++ b/737/InvasionFront_CD8_block1_x1_y10_patient737_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 25136.7, + "Num Detections": 28091, + "Num Negative": 25691, + "Num Positive": 2400, + "Positive %": 8.544, + "Num Positive per mm^2": 871.0 + } +} \ No newline at end of file diff --git a/737/InvasionFront_CD8_block1_x2_y10_patient737_1.json b/737/InvasionFront_CD8_block1_x2_y10_patient737_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb736a6fc0945bddc744e48144a9384894f90c05 --- /dev/null +++ b/737/InvasionFront_CD8_block1_x2_y10_patient737_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6371.6, + "Centroid Y µm": 25186.7, + "Num Detections": 29025, + "Num Negative": 26704, + "Num Positive": 2321, + "Positive %": 7.997, + "Num Positive per mm^2": 855.3 + } +} \ No newline at end of file diff --git a/737/TumorCenter_CD3_block1_x1_y12_patient737_0.json b/737/TumorCenter_CD3_block1_x1_y12_patient737_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d4aac1a2de3d29742044fccd0d737491316a5c16 --- /dev/null +++ b/737/TumorCenter_CD3_block1_x1_y12_patient737_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 29959.1, + "Num Detections": 15216, + "Num Negative": 6063, + "Num Positive": 9153, + "Positive %": 60.15, + "Num Positive per mm^2": 5289.2 + } +} \ No newline at end of file diff --git a/737/TumorCenter_CD3_block1_x2_y12_patient737_1.json b/737/TumorCenter_CD3_block1_x2_y12_patient737_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c032c60c3200039c29fa333ce6e351928c98fccf --- /dev/null +++ b/737/TumorCenter_CD3_block1_x2_y12_patient737_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6644.8, + "Centroid Y µm": 29990.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/737/TumorCenter_CD8_block1_x1_y10_patient737_0.json b/737/TumorCenter_CD8_block1_x1_y10_patient737_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20259dd0a9a1c747d86f6ae7af43c4cf80efe0ce --- /dev/null +++ b/737/TumorCenter_CD8_block1_x1_y10_patient737_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 34456.8, + "Num Detections": 28521, + "Num Negative": 28045, + "Num Positive": 476, + "Positive %": 1.669, + "Num Positive per mm^2": 175.89 + } +} \ No newline at end of file diff --git a/737/TumorCenter_CD8_block1_x2_y10_patient737_1.json b/737/TumorCenter_CD8_block1_x2_y10_patient737_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a887f2c980a620c3ff04245e9e13338c36899fee --- /dev/null +++ b/737/TumorCenter_CD8_block1_x2_y10_patient737_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9120.2, + "Centroid Y µm": 34181.9, + "Num Detections": 24869, + "Num Negative": 23166, + "Num Positive": 1703, + "Positive %": 6.848, + "Num Positive per mm^2": 651.5 + } +} \ No newline at end of file diff --git a/737/history_text.txt b/737/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6d710de29391809582b2d270a34bfa8f7d3eab9 --- /dev/null +++ b/737/history_text.txt @@ -0,0 +1 @@ +Patient with clinical and computed tomography cT2 oropharyngeal carcinoma on the right. There is now an indication for tumor resection, neck dissection, tracheotomy and PEG placement. The patient had ample opportunity to ask questions about the procedure before the operation. Due to an unforeseen illness, the operation could not be performed as planned by the agreed representative of . During a detailed preoperative discussion, both the patient and his witnesses expressly agreed with and as the representative of . The patient was also offered the option of rescheduling the appointment several times. The patient now expressly wishes to have the operation performed by the two senior medical representatives mentioned above. \ No newline at end of file diff --git a/737/icd_codes.txt b/737/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adc050c8f628f1e558c676f540ed678cb6876eb8 --- /dev/null +++ b/737/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/737/ops_codes.txt b/737/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..210a4cacbe92500182c69ed283ca54955073dd50 --- /dev/null +++ b/737/ops_codes.txt @@ -0,0 +1 @@ +Laserresektion partiell Zunge durch Pharyngotomie sonstige[5-251.2x ] Anlegen einer PEG durch Fadendurchzugsmethode[5-431.20 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Weichgaumenteilresektion[5-272.1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Sonstige Temporäre Tracheostomie[5-311.x ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] \ No newline at end of file diff --git a/737/patient_clinical_data.json b/737/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f4b2138401305319a4be8b6072b4bfe34ae67d2a --- /dev/null +++ b/737/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/737/patient_pathological_data.json b/737/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..798c3e4a12da728fd5b9e763319c6d03c68b98b3 --- /dev/null +++ b/737/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "737", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/738/InvasionFront_CD8_block19_x1_y12_patient738_0.json b/738/InvasionFront_CD8_block19_x1_y12_patient738_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26f5597c06cf80246a42ab157952d1490e8bff51 --- /dev/null +++ b/738/InvasionFront_CD8_block19_x1_y12_patient738_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3934.5, + "Centroid Y µm": 39400.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/738/InvasionFront_CD8_block19_x2_y12_patient738_1.json b/738/InvasionFront_CD8_block19_x2_y12_patient738_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e790a938a4cc7a059f59122d1d9b632de566ee7 --- /dev/null +++ b/738/InvasionFront_CD8_block19_x2_y12_patient738_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6198.6, + "Centroid Y µm": 39344.7, + "Num Detections": 14611, + "Num Negative": 14566, + "Num Positive": 45, + "Positive %": 0.308, + "Num Positive per mm^2": 30.33 + } +} \ No newline at end of file diff --git a/738/TumorCenter_CD3_block19_x1_y12_patient738_0.json b/738/TumorCenter_CD3_block19_x1_y12_patient738_0.json new file mode 100644 index 0000000000000000000000000000000000000000..99995c24d9fc0c591e228688b628a297ba67b0e5 --- /dev/null +++ b/738/TumorCenter_CD3_block19_x1_y12_patient738_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7049.6, + "Centroid Y µm": 31402.3, + "Num Detections": 4029, + "Num Negative": 2661, + "Num Positive": 1368, + "Positive %": 33.95, + "Num Positive per mm^2": 1704.5 + } +} \ No newline at end of file diff --git a/738/TumorCenter_CD3_block19_x2_y12_patient738_1.json b/738/TumorCenter_CD3_block19_x2_y12_patient738_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e6ecb47ea4a24d5a282f9282c2a6cd176f86145 --- /dev/null +++ b/738/TumorCenter_CD3_block19_x2_y12_patient738_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9282.8, + "Centroid Y µm": 31145.3, + "Num Detections": 7567, + "Num Negative": 4980, + "Num Positive": 2587, + "Positive %": 34.19, + "Num Positive per mm^2": 2116.6 + } +} \ No newline at end of file diff --git a/738/TumorCenter_CD8_block19_x1_y12_patient738_0.json b/738/TumorCenter_CD8_block19_x1_y12_patient738_0.json new file mode 100644 index 0000000000000000000000000000000000000000..01652ece2ace746feb3a682d23f20155485ddf4a --- /dev/null +++ b/738/TumorCenter_CD8_block19_x1_y12_patient738_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6794.0, + "Centroid Y µm": 40690.7, + "Num Detections": 8746, + "Num Negative": 8382, + "Num Positive": 364, + "Positive %": 4.162, + "Num Positive per mm^2": 402.02 + } +} \ No newline at end of file diff --git a/738/TumorCenter_CD8_block19_x2_y12_patient738_1.json b/738/TumorCenter_CD8_block19_x2_y12_patient738_1.json new file mode 100644 index 0000000000000000000000000000000000000000..376a09cc8eb25baee6bcc36211b3f48b0d856a2c --- /dev/null +++ b/738/TumorCenter_CD8_block19_x2_y12_patient738_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9150.0, + "Centroid Y µm": 40836.3, + "Num Detections": 13882, + "Num Negative": 12849, + "Num Positive": 1033, + "Positive %": 7.441, + "Num Positive per mm^2": 722.06 + } +} \ No newline at end of file diff --git a/738/history_text.txt b/738/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0bff6b1778ffe846802bb90432e910576851ee3 --- /dev/null +++ b/738/history_text.txt @@ -0,0 +1 @@ +The patient had a panendoscopy with a sample biopsy. This revealed at least a cT2 cN0 glottic carcinoma on the left side with submucosal extension of at least 1 cm to the subglottic and 1 ˝ cm to the supraglottic. ENT mirror examination shows aryfixation and vocal fold paresis on the left side. The tumor grows submucosally. B-scan sonography shows a cN0 neck status. An external CT neck/thorax revealed clinical findings without definite evidence of thyroid cartilage infiltration. Based on the medical history and clinical findings, the above-mentioned procedure was indicated. The patient had sufficient time and opportunity to ask questions about the operation and the procedure. \ No newline at end of file diff --git a/738/icd_codes.txt b/738/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..57431305266e4dc4691bcc4b14acb4bbd02e2906 --- /dev/null +++ b/738/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 L] Halslymphknotenmetastasen[C77.0 L] \ No newline at end of file diff --git a/738/patient_clinical_data.json b/738/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4ae20c97eb032e9b65e1f4afc77553305fb352bc --- /dev/null +++ b/738/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 60, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/738/patient_pathological_data.json b/738/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..006e62453f68429b055d79832b2153cb74905ca0 --- /dev/null +++ b/738/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "738", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/739/InvasionFront_CD3_block7_x3_y7_patient739_0.json b/739/InvasionFront_CD3_block7_x3_y7_patient739_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bd563529c7fdaa1673d4be3a3b946190ec951c51 --- /dev/null +++ b/739/InvasionFront_CD3_block7_x3_y7_patient739_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11330.3, + "Centroid Y µm": 17084.4, + "Num Detections": 16018, + "Num Negative": 15442, + "Num Positive": 576, + "Positive %": 3.596, + "Num Positive per mm^2": 252.83 + } +} \ No newline at end of file diff --git a/739/InvasionFront_CD3_block7_x4_y7_patient739_1.json b/739/InvasionFront_CD3_block7_x4_y7_patient739_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0085da9839a16693c4fd6164b2cbdedcba13cbd1 --- /dev/null +++ b/739/InvasionFront_CD3_block7_x4_y7_patient739_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14042.6, + "Centroid Y µm": 17066.0, + "Num Detections": 20009, + "Num Negative": 18612, + "Num Positive": 1397, + "Positive %": 6.982, + "Num Positive per mm^2": 581.96 + } +} \ No newline at end of file diff --git a/739/TumorCenter_CD3_block7_x3_y7_patient739_0.json b/739/TumorCenter_CD3_block7_x3_y7_patient739_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26089b92a139410e265e7c7825a047a0fe9d9205 --- /dev/null +++ b/739/TumorCenter_CD3_block7_x3_y7_patient739_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 17615.7, + "Num Detections": 16420, + "Num Negative": 15249, + "Num Positive": 1171, + "Positive %": 7.132, + "Num Positive per mm^2": 491.96 + } +} \ No newline at end of file diff --git a/742/surgery_description.txt b/742/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..930f03c462a391e8de89a41198f9f0d0a3dccd6a --- /dev/null +++ b/742/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Right tongue partial resection, Bilateral neck dissection, and PEG placement, Tracheotomy diff --git a/743/ops_codes.txt b/743/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb2c7c45a8fb156e7c7b66903ca31a02f2cb4cae --- /dev/null +++ b/743/ops_codes.txt @@ -0,0 +1 @@ +Hemilaryngektomie horizontal supraglottisch[5-301.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Temporäre Tracheotomie[5-311.0 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Diagnostische Laryngoskopie Mikrolaryngoskopie[1-610.2 ] \ No newline at end of file diff --git a/743/surgery_description.txt b/743/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..821b982fba6dfcd235567096ecaf50d4e7a1d13b --- /dev/null +++ b/743/surgery_description.txt @@ -0,0 +1 @@ +Horizontal laryngeal partial resection according to Alonso, Modified radical bilateral neck dissection, Tracheotomy, PEG, Endoscopy diff --git a/743/surgery_report.txt b/743/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f3d4685a0944ab9f220328343fda283b0fc2609f --- /dev/null +++ b/743/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthetist, the first step is microlaryngoscopy: this reveals a partially exophytic mass in the laryngeal epiglottis, which clearly reaches the midline on the right. The aryepiglottic fold is just affected, but the right arytenoid cartilage is free. The right pouch fold and vocal fold are free. On the left side, the tumor extends minimally over the laryngeal epiglottis midline, otherwise the vocal folds, the pouch folds and the aryepiglottic fold are free of irritation. The tumor grows submucosally into the pre-epiglottic field and bulges the right vallecula without breaking through it. Now proceed with the flexible esophagogastroscope under constant air insufflation with positive diaphanoscopy. Insertion of the troicart and placement of the PEG tube in the typical manner using the thread pull-through method. Now proceed to tumor resection and neck dissection on both sides: First, a U-shaped incision is made to form the apron flap, starting at the level of the cricoid cartilage. Dissection through the subcutaneous tissue and platysma. Subplatysmal dissection of the apron flap is then performed up to the level of the hyoid bone. Now turn first to the right side of the neck: Dissect along the anterior border of the sternocleidomastoid and then expose the digastric muscle and the omohyoid muscle. Identify and protect the accessorius nerve. Now clamp the surgical site with the retractors and dissect the internal jugular vein from caudal to cranial. Simultaneous dissection of the facial vein. The medial neck preparation is then formed after identification and protection of the hypoglossal nerve, the superior thyroid artery and the submandibular gland. In addition, the superior layngeal nerve and its accompanying vessels are identified here. Now turn to the lateral neck preparation. First isolate the internal jugular vein, identify and protect the vagus nerve and then dissect from cranial to caudal, protecting the accessor nerve and the plexus branches. Now turn to the neck dissection of the left side: identical procedure here. Dissect the sternocleidomastoid muscle along its anterior edge. Identify and spare the accessorius nerve. Set the border at the posterior digastric venter muscle and omohyoid muscle. Spanning of the surgical area and dissection of the internal jugular vein from caudal to cranial. After skeletonizing the submandibular gland, the median neck preparation is dissected after identifying and sparing the hypoglossal nerve, cervical nerve and superior laryngeal nerve as well as the superior thyroid artery. Then, after isolating the jugular vein, the vagus nerve is identified and spared and the lateral neck preparation is formed from cranial to caudal, sparing the plexus branches. Far in the caudal region, there is initially a watery flow, which may be due to injury to a small hilar vessel. For this reason, the area is carefully bipolized and a TachoSil swab is placed at the end. The surgical site is then completely dry. Level VI is now also prepared. This is done directly caudal to the hyoid bone and on the surface of the thyroid and omohyoid muscles and caudally to the cricoid cartilage. The anterior jugular vein is ligated on both sides. Now spread the prelaryngeal and pretracheal muscles. Identify the thyroid isthmus. Identification of the inferior thyroid vein and bipolization of the latter. Undermining of the thyroid isthmus, clamping with 2 Péan clamps and transection of the same. This is followed by suturing with Serafit 0 sutures. Now explore the anterior tracheal wall between the 2nd and 3rd tracheal ring. Form a Björk flap and epithelialize it in the caudal area. Now skeletonize the hyoid bone. Separate the omohyoid and thyroid muscles at the cranial insertions and open them caudally. Now carefully isolate the superior laryngeal nerve on both sides and separate it from the nearby upper horn of the thyroid cartilage. The tumor can now be palpated in the thyrohyoid membrane on the right side. However, it can be seen that it does not infiltrate the thyroid cartilage. Now add , which opens the thyrohyoid membrane on the left side and enters the vallecula region. The epiglottis is then opened outwards with the tumor grasping forceps and the exact extent of the tumor is identified. Resection is then performed along the vallecula on the right side, then via resection of the pharyngo-epiglottic fold and further resection along the aryepiglottic fold on the right side. Shortly before the arytenoid cartilage is reached, the resection is then continued from posterior to anterior, partially taking along the fold of the pocket. On the left side, on the other hand, most of the pocket fold and the aryepiglottic fold can be spared and the resection goes directly from the laryngeal epiglottis into the pharyngo-epiglottic fold. The specimen is sent for final histology. The resection appears to be clearly in sano. Nevertheless, 3 frozen sections are taken, which are then found to be tumor-free. Now careful hemostasis. The mucosa of the right pocket fold is readapted to the thyroid cartilage as far as possible, the upper horn of the thyroid cartilage is resected on both sides while sparing the superior laryngeal nerves. On the left side, the mucosa of the epiglottis attachment is adapted to the thyroid cartilage. The mucosa of the pharyngeal wall is then laterally readapted to that of the base of the tongue on both sides using three 3/0 Vicryl sutures each. The thyroid cartilage is now reattached to the hyoid bone. This is secured with three lateral 0-Vicryl sutures and an additional central 0-Vicryl suture placed directly caudal to the incisura thyroidea. All sutures are advanced and pass around the hyoid bone. Then all are successively adapted and attached after the head has been reclined. In addition, an attempt is made to readapt the mucosa as well as possible with 3/0 Vicryl sutures. The thyrohyoid and omohyoid muscles are then reattached and both muscles are sutured to the hyoid bone so that the resection site is covered. Then careful hemostasis and irrigation with hydrogen and Ringer's. Placement of 2 Redon drains. Auklapping of the apron flap and epithelialization of the tracheostoma and two-layer wound closure using subcutaneous and skin sutures. Intraoperative administration of 3 g Unacid. The patient should not be fed orally for at least one week. This should be followed by an X-ray papsule. After receiving the final histology, presentation at the tumor conference. \ No newline at end of file diff --git a/744/InvasionFront_CD8_block3_x6_y5_patient744_1.json b/744/InvasionFront_CD8_block3_x6_y5_patient744_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d1edbbe09528cfcf4ce55f7b25a390219d0292a --- /dev/null +++ b/744/InvasionFront_CD8_block3_x6_y5_patient744_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20225.5, + "Centroid Y µm": 12262.9, + "Num Detections": 22271, + "Num Negative": 21220, + "Num Positive": 1051, + "Positive %": 4.719, + "Num Positive per mm^2": 406.99 + } +} \ No newline at end of file diff --git a/744/TumorCenter_CD3_block3_x6_y5_patient744_1.json b/744/TumorCenter_CD3_block3_x6_y5_patient744_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ffdaf324a1be3b00ee51cc0cceac91bf754244e --- /dev/null +++ b/744/TumorCenter_CD3_block3_x6_y5_patient744_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 18790.1, + "Num Detections": 5092, + "Num Negative": 4026, + "Num Positive": 1066, + "Positive %": 20.93, + "Num Positive per mm^2": 1735.7 + } +} \ No newline at end of file diff --git a/744/TumorCenter_CD8_block3_x5_y5_patient744_0.json b/744/TumorCenter_CD8_block3_x5_y5_patient744_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0877e555e6b05732127033b606002d84c4fab7e --- /dev/null +++ b/744/TumorCenter_CD8_block3_x5_y5_patient744_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17091.0, + "Centroid Y µm": 14167.5, + "Num Detections": 24023, + "Num Negative": 23744, + "Num Positive": 279, + "Positive %": 1.161, + "Num Positive per mm^2": 110.51 + } +} \ No newline at end of file diff --git a/744/TumorCenter_CD8_block3_x6_y5_patient744_1.json b/744/TumorCenter_CD8_block3_x6_y5_patient744_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7521b0da0e4cbc7153d680bfed70ca40bb273721 --- /dev/null +++ b/744/TumorCenter_CD8_block3_x6_y5_patient744_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19664.6, + "Centroid Y µm": 14292.4, + "Num Detections": 20203, + "Num Negative": 17941, + "Num Positive": 2262, + "Positive %": 11.2, + "Num Positive per mm^2": 979.92 + } +} \ No newline at end of file diff --git a/744/history_text.txt b/744/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..48d7d640c914705a575b2af993f83d4fcf09ab63 --- /dev/null +++ b/744/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the oral cavity and oropharynx on the right. The carcinoma is located in the middle body of the tongue, radiates to the floor of the mouth, extends posteriorly to the base of the tongue and spreads to the tonsil lobe. Histologically squamous cell carcinoma. Therefore, the above-mentioned surgery was indicated. Repeated pharyngoscopy and laryngoscopy as well as oral cavity inspection: The tumor is found to be exophytic in the body of the tongue, does not cross the midline, extends across the floor of the mouth to the glossoalveolar fold, to the tonsillar loge, and runs downwards to the end of the tonsil. Infiltration also towards the base of the tongue. This confirms the indication. \ No newline at end of file diff --git a/744/icd_codes.txt b/744/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e525cd3c66c9847434405ae260b9228b25b77d82 --- /dev/null +++ b/744/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 R] Zungenrandkarzinom[C02.1 R] Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/744/ops_codes.txt b/744/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c72d569fecbb91b9d331f0b063a677a2539df53a --- /dev/null +++ b/744/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.02 ] Sonstige Pharyngotomie[5-290.x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 6 Regionen[5-403.22 B] Permanente Tracheotomie[5-312.0 ] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Andere plastische Rekonstruktion Arterien Kopf und Hals extrakraniell A. carotis externa[5-397.03 R] \ No newline at end of file diff --git a/744/patient_clinical_data.json b/744/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7f8e4616ba1502b89335dd85fb2fbc9bff13e48f --- /dev/null +++ b/744/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/744/patient_pathological_data.json b/744/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7dd2caf1cc568bff488994f3758f7fb57cd724dc --- /dev/null +++ b/744/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "744", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 24.0 +} \ No newline at end of file diff --git a/744/surgery_description.txt b/744/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/744/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/745/InvasionFront_CD3_block3_x5_y12_patient745_0.json b/745/InvasionFront_CD3_block3_x5_y12_patient745_0.json new file mode 100644 index 0000000000000000000000000000000000000000..221865df9e984f69343e823d4779f9a170d0809e --- /dev/null +++ b/745/InvasionFront_CD3_block3_x5_y12_patient745_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15803.4, + "Centroid Y µm": 37203.0, + "Num Detections": 16137, + "Num Negative": 14944, + "Num Positive": 1193, + "Positive %": 7.393, + "Num Positive per mm^2": 592.87 + } +} \ No newline at end of file diff --git a/745/InvasionFront_CD3_block3_x6_y12_patient745_1.json b/745/InvasionFront_CD3_block3_x6_y12_patient745_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ddf4aba557c815405ec8af62d5c0cec798e83ee4 --- /dev/null +++ b/745/InvasionFront_CD3_block3_x6_y12_patient745_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18387.5, + "Centroid Y µm": 37260.1, + "Num Detections": 18344, + "Num Negative": 17791, + "Num Positive": 553, + "Positive %": 3.015, + "Num Positive per mm^2": 243.06 + } +} \ No newline at end of file diff --git a/745/InvasionFront_CD8_block3_x5_y10_patient745_0.json b/745/InvasionFront_CD8_block3_x5_y10_patient745_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6ac24d299aaca6e80a20560aaede578abdc7403 --- /dev/null +++ b/745/InvasionFront_CD8_block3_x5_y10_patient745_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17340.8, + "Centroid Y µm": 24711.9, + "Num Detections": 18527, + "Num Negative": 15862, + "Num Positive": 2665, + "Positive %": 14.38, + "Num Positive per mm^2": 1090.2 + } +} \ No newline at end of file diff --git a/745/InvasionFront_CD8_block3_x6_y10_patient745_1.json b/745/InvasionFront_CD8_block3_x6_y10_patient745_1.json new file mode 100644 index 0000000000000000000000000000000000000000..79e4df26518530b8f66e63ae43656bbf4949cd8a --- /dev/null +++ b/745/InvasionFront_CD8_block3_x6_y10_patient745_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20014.4, + "Centroid Y µm": 24761.9, + "Num Detections": 21431, + "Num Negative": 19507, + "Num Positive": 1924, + "Positive %": 8.978, + "Num Positive per mm^2": 775.5 + } +} \ No newline at end of file diff --git a/745/TumorCenter_CD3_block3_x5_y10_patient745_0.json b/745/TumorCenter_CD3_block3_x5_y10_patient745_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6cc9dde64189fef869aaabc3e04ed9e73f1a834 --- /dev/null +++ b/745/TumorCenter_CD3_block3_x5_y10_patient745_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15485.4, + "Centroid Y µm": 31279.5, + "Num Detections": 11380, + "Num Negative": 9809, + "Num Positive": 1571, + "Positive %": 13.8, + "Num Positive per mm^2": 1026.4 + } +} \ No newline at end of file diff --git a/745/TumorCenter_CD3_block3_x6_y10_patient745_1.json b/745/TumorCenter_CD3_block3_x6_y10_patient745_1.json new file mode 100644 index 0000000000000000000000000000000000000000..73432b7d24da9ce35397b2b8b19a806952aad29c --- /dev/null +++ b/745/TumorCenter_CD3_block3_x6_y10_patient745_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18028.0, + "Centroid Y µm": 31520.8, + "Num Detections": 14852, + "Num Negative": 10532, + "Num Positive": 4320, + "Positive %": 29.09, + "Num Positive per mm^2": 2080.8 + } +} \ No newline at end of file diff --git a/745/TumorCenter_CD8_block3_x5_y10_patient745_0.json b/745/TumorCenter_CD8_block3_x5_y10_patient745_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7124ab481f7edd918f31cdbd7f13030168c02050 --- /dev/null +++ b/745/TumorCenter_CD8_block3_x5_y10_patient745_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 26386.0, + "Num Detections": 21906, + "Num Negative": 20409, + "Num Positive": 1497, + "Positive %": 6.834, + "Num Positive per mm^2": 592.27 + } +} \ No newline at end of file diff --git a/745/ops_codes.txt b/745/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9b0bfb92f49870aa460fab1252e0bf1dabcd152b --- /dev/null +++ b/745/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.03 B] Permanente Tracheotomie[5-312.0 ] Uvulateilresektion[5-272.1 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen sonstige[5-858.7x R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/746/InvasionFront_CD3_block4_x1_y12_patient746_0.json b/746/InvasionFront_CD3_block4_x1_y12_patient746_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5646c1a8afedfd2840836709831996e284f54921 --- /dev/null +++ b/746/InvasionFront_CD3_block4_x1_y12_patient746_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 35556.2, + "Num Detections": 24712, + "Num Negative": 18403, + "Num Positive": 6309, + "Positive %": 25.53, + "Num Positive per mm^2": 2574.3 + } +} \ No newline at end of file diff --git a/746/InvasionFront_CD3_block4_x2_y12_patient746_1.json b/746/InvasionFront_CD3_block4_x2_y12_patient746_1.json new file mode 100644 index 0000000000000000000000000000000000000000..85bc6c33b2e4d2d3871655e28a00bf98271eac92 --- /dev/null +++ b/746/InvasionFront_CD3_block4_x2_y12_patient746_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8595.4, + "Centroid Y µm": 35581.2, + "Num Detections": 24390, + "Num Negative": 19821, + "Num Positive": 4569, + "Positive %": 18.73, + "Num Positive per mm^2": 1878.0 + } +} \ No newline at end of file diff --git a/746/TumorCenter_CD3_block4_x1_y12_patient746_0.json b/746/TumorCenter_CD3_block4_x1_y12_patient746_0.json new file mode 100644 index 0000000000000000000000000000000000000000..67ac0fdc006e4e1c949277c9da07511adfe54e18 --- /dev/null +++ b/746/TumorCenter_CD3_block4_x1_y12_patient746_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 30908.6, + "Num Detections": 26953, + "Num Negative": 22720, + "Num Positive": 4233, + "Positive %": 15.71, + "Num Positive per mm^2": 1558.7 + } +} \ No newline at end of file