diff --git a/159/surgery_description.txt b/159/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..767f23ecd80dae120e3bc9dc21a71b411a0d3f30 --- /dev/null +++ b/159/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Defect coverage, Free flap (Radial), PEG placement diff --git a/160/InvasionFront_CD3_block16_x4_y11_patient160_1.json b/160/InvasionFront_CD3_block16_x4_y11_patient160_1.json new file mode 100644 index 0000000000000000000000000000000000000000..813fc38e53fbc057f9c3a7fe7110df2c71ae2d7b --- /dev/null +++ b/160/InvasionFront_CD3_block16_x4_y11_patient160_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14104.6, + "Centroid Y µm": 31940.6, + "Num Detections": 20418, + "Num Negative": 19666, + "Num Positive": 752, + "Positive %": 3.683, + "Num Positive per mm^2": 326.13 + } +} \ No newline at end of file diff --git a/160/InvasionFront_CD8_block16_x3_y11_patient160_0.json b/160/InvasionFront_CD8_block16_x3_y11_patient160_0.json new file mode 100644 index 0000000000000000000000000000000000000000..df546f595d6f43ed77f0b5554eeda1d51b278ff1 --- /dev/null +++ b/160/InvasionFront_CD8_block16_x3_y11_patient160_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10570.8, + "Centroid Y µm": 26977.4, + "Num Detections": 19772, + "Num Negative": 19451, + "Num Positive": 321, + "Positive %": 1.624, + "Num Positive per mm^2": 147.56 + } +} \ No newline at end of file diff --git a/160/InvasionFront_CD8_block16_x4_y11_patient160_1.json b/160/InvasionFront_CD8_block16_x4_y11_patient160_1.json new file mode 100644 index 0000000000000000000000000000000000000000..408626c1bd35ecd4f06f456772302900a977f751 --- /dev/null +++ b/160/InvasionFront_CD8_block16_x4_y11_patient160_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13080.4, + "Centroid Y µm": 26821.0, + "Num Detections": 19284, + "Num Negative": 19065, + "Num Positive": 219, + "Positive %": 1.136, + "Num Positive per mm^2": 104.75 + } +} \ No newline at end of file diff --git a/160/TumorCenter_CD3_block16_x4_y12_patient160_1.json b/160/TumorCenter_CD3_block16_x4_y12_patient160_1.json new file mode 100644 index 0000000000000000000000000000000000000000..21e7047ad2abc6f76d492ed04730e3cd74765289 --- /dev/null +++ b/160/TumorCenter_CD3_block16_x4_y12_patient160_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13342.9, + "Centroid Y µm": 30883.6, + "Num Detections": 15487, + "Num Negative": 14897, + "Num Positive": 590, + "Positive %": 3.81, + "Num Positive per mm^2": 276.91 + } +} \ No newline at end of file diff --git a/160/TumorCenter_CD8_block16_x3_y11_patient160_0.json b/160/TumorCenter_CD8_block16_x3_y11_patient160_0.json new file mode 100644 index 0000000000000000000000000000000000000000..78fa012a9c1a59f091e340accef904193d53e0a0 --- /dev/null +++ b/160/TumorCenter_CD8_block16_x3_y11_patient160_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10419.5, + "Centroid Y µm": 27910.2, + "Num Detections": 15340, + "Num Negative": 15069, + "Num Positive": 271, + "Positive %": 1.767, + "Num Positive per mm^2": 160.24 + } +} \ No newline at end of file diff --git a/160/TumorCenter_CD8_block16_x4_y11_patient160_1.json b/160/TumorCenter_CD8_block16_x4_y11_patient160_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc22a9f2e408f21552af7865af9d46acea895426 --- /dev/null +++ b/160/TumorCenter_CD8_block16_x4_y11_patient160_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13317.9, + "Centroid Y µm": 27810.3, + "Num Detections": 8020, + "Num Negative": 6710, + "Num Positive": 1310, + "Positive %": 16.33, + "Num Positive per mm^2": 1240.6 + } +} \ No newline at end of file diff --git a/160/history_text.txt b/160/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a32a079c1b102f621a64c52f5ddb811f9b00be8b --- /dev/null +++ b/160/history_text.txt @@ -0,0 +1 @@ +The patient has an unclear change in the right edge of the tongue. A PE had revealed a Cis with transition to an invasive carcinoma. In the interdisciplinary tumor conference, the indication for an excisional biopsy was made. \ No newline at end of file diff --git a/160/icd_codes.txt b/160/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b471b784d2b9d9c09a5a3b27210fcf133740a8a5 --- /dev/null +++ b/160/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 ] \ No newline at end of file diff --git a/160/ops_codes.txt b/160/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0bc2ac3458661425e4194cd280486ffd56f93129 --- /dev/null +++ b/160/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Ösophagogastroskopie[1-631 ] Biopsie an der Zunge durch Inzision[1-541 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Inzision am Zungenrand[5-250.0 ] \ No newline at end of file diff --git a/160/patient_clinical_data.json b/160/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..11e7a008e7cc4c919bbdac3174cc031c45d3d073 --- /dev/null +++ b/160/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 48, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/160/patient_pathological_data.json b/160/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a99a559bfec409b5fedd366e9f950775292f7a6f --- /dev/null +++ b/160/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "160", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 15, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/160/surgery_description.txt b/160/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c9733ad9ba089637e0be3a5811531d10d3a27cde --- /dev/null +++ b/160/surgery_description.txt @@ -0,0 +1 @@ +Excision of right tongue margin RF (Radial Forearm) flap, Panendoscopy diff --git a/160/surgery_report.txt b/160/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c7b804bee44de9a56e344f48e9848f017a11bc2 --- /dev/null +++ b/160/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, rigid tracheoscopy is performed under laryngoscopic control. This is successful without any problems. Mirroring up to the carina. This is clear on all sides. In the area of the posterior tracheal wall, a small induration or protrusion can be seen paramedian to the left about 5 cm subglottically. This is not exophytic and does not appear primarily suspicious for malignancy. Then problem-free intubation by the surgeon. Positioning by the surgeon. Esophagogastroscopy is performed first. Enter with the gastroscope under laryngoscopic control. Mirroring into the stomach without any problems. Here, food residues are clearly visible, but after aspiration of these, the mucosal conditions are unremarkable on all sides. On endoscopy, clear mucosal changes in the sense of reflux esophagitis are noticeable. Otherwise, however, no exophytic masses. Now enter with the small bore tube. Inspection of the hypopharynx. The hypopharynx is clearly visible up to the esophageal entrance, even the postcricoid region is clear without exophytic masses. No suspicious changes in the area of the base of the tongue, vallecula and epiglottis. Adjustment of the endolarynx. Inconspicuous mucosal conditions without exophytic tumor growth. Inspection of the oral cavity. A coarse, whitish, circumscribed change in the right glossotonsillar groove is seen in the area of the transition to the alveolar ridge anteriorly on the edge of the tongue, the mucosa is slightly reddened and uneven and leads to clearly leukoplakic changes in the area of the edge of the tongue, transitioning to the floor of the mouth, with whitish, non-wipeable coatings. The decision is made to excise the suspicious, indurated mass, which, however, does not move into the base of the tongue on palpation, while at the same time taking the suspicious mucosal changes anteriorly. Now first insert the mouth retractor and mark the resection margins with the electric needle. Dissection with scissors, removing the mucosal changes in the area of the tumorous changes. Removal of the mucosa and the underlying submucosal tissue up to the former tonsil lobe or base of the tongue. All preparation steps under careful hemostasis using bipolar coagulation. The preparation is now marked with sutures. It extends from the right glossotonsillar groove over the alveolar ridge to the anterior third of the right edge of the tongue, passing over to the floor of the mouth. This is followed by thread marking in the anterior (long/long) and lateral (short/short) directions. Representative edge samples are then taken in the area of the anterior edge of the tongue as well as halfway along the area of the floor of the mouth transition and the back of the tongue medially and finally a resection in the area of the cranial tonsil lobe. Then renewed careful inspection and hemostasis using bipolar coagulation. Insertion of hydrogen and Ringer swabs. Meticulous hemostasis. Finally, absolutely dry wound conditions. End of the procedure at this point without any indication of complications. \ No newline at end of file diff --git a/161/InvasionFront_CD3_block18_x1_y12_patient161_0.json b/161/InvasionFront_CD3_block18_x1_y12_patient161_0.json new file mode 100644 index 0000000000000000000000000000000000000000..372f09ec26b92bb7428d813f137c65736d265f00 --- /dev/null +++ b/161/InvasionFront_CD3_block18_x1_y12_patient161_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3248.3, + "Centroid Y µm": 34281.8, + "Num Detections": 18277, + "Num Negative": 18013, + "Num Positive": 264, + "Positive %": 1.444, + "Num Positive per mm^2": 122.23 + } +} \ No newline at end of file diff --git a/161/InvasionFront_CD3_block18_x2_y12_patient161_1.json b/161/InvasionFront_CD3_block18_x2_y12_patient161_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3753291961ce240fae232d522ad99b5dd54d495 --- /dev/null +++ b/161/InvasionFront_CD3_block18_x2_y12_patient161_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5921.9, + "Centroid Y µm": 34431.8, + "Num Detections": 22764, + "Num Negative": 22658, + "Num Positive": 106, + "Positive %": 0.4656, + "Num Positive per mm^2": 45.63 + } +} \ No newline at end of file diff --git a/161/InvasionFront_CD8_block18_x1_y12_patient161_0.json b/161/InvasionFront_CD8_block18_x1_y12_patient161_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6e248f60cbce40a8e744c74c80aca0905f5e5889 --- /dev/null +++ b/161/InvasionFront_CD8_block18_x1_y12_patient161_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4145.1, + "Centroid Y µm": 36933.0, + "Num Detections": 10937, + "Num Negative": 10817, + "Num Positive": 120, + "Positive %": 1.097, + "Num Positive per mm^2": 70.8 + } +} \ No newline at end of file diff --git a/161/InvasionFront_CD8_block18_x2_y12_patient161_1.json b/161/InvasionFront_CD8_block18_x2_y12_patient161_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1a5b44b7499b58d5093c668359b88c7624512e3e --- /dev/null +++ b/161/InvasionFront_CD8_block18_x2_y12_patient161_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6921.3, + "Centroid Y µm": 37055.4, + "Num Detections": 17637, + "Num Negative": 17585, + "Num Positive": 52, + "Positive %": 0.2948, + "Num Positive per mm^2": 25.3 + } +} \ No newline at end of file diff --git a/161/TumorCenter_CD3_block18_x1_y12_patient161_0.json b/161/TumorCenter_CD3_block18_x1_y12_patient161_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2f22e043429c13d45d67d839a6145e9209cb0a46 --- /dev/null +++ b/161/TumorCenter_CD3_block18_x1_y12_patient161_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3408.4, + "Centroid Y µm": 28802.8, + "Num Detections": 20127, + "Num Negative": 20105, + "Num Positive": 22, + "Positive %": 0.1093, + "Num Positive per mm^2": 10.82 + } +} \ No newline at end of file diff --git a/161/TumorCenter_CD3_block18_x2_y12_patient161_1.json b/161/TumorCenter_CD3_block18_x2_y12_patient161_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72e0478f1b7cab0fede6fcd386c52afbc513c0d8 --- /dev/null +++ b/161/TumorCenter_CD3_block18_x2_y12_patient161_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5836.3, + "Centroid Y µm": 28816.6, + "Num Detections": 8856, + "Num Negative": 8665, + "Num Positive": 191, + "Positive %": 2.157, + "Num Positive per mm^2": 119.02 + } +} \ No newline at end of file diff --git a/161/TumorCenter_CD8_block18_x1_y12_patient161_0.json b/161/TumorCenter_CD8_block18_x1_y12_patient161_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d5b4f9ae2d0208d9128ac0f8279363268d65f944 --- /dev/null +++ b/161/TumorCenter_CD8_block18_x1_y12_patient161_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 29859.2, + "Num Detections": 16428, + "Num Negative": 16397, + "Num Positive": 31, + "Positive %": 0.1887, + "Num Positive per mm^2": 15.03 + } +} \ No newline at end of file diff --git a/161/TumorCenter_CD8_block18_x2_y12_patient161_1.json b/161/TumorCenter_CD8_block18_x2_y12_patient161_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bc4743b3898914dd7509fe32798551b07fdf3ec1 --- /dev/null +++ b/161/TumorCenter_CD8_block18_x2_y12_patient161_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5871.9, + "Centroid Y µm": 29884.2, + "Num Detections": 15882, + "Num Negative": 15762, + "Num Positive": 120, + "Positive %": 0.7556, + "Num Positive per mm^2": 65.87 + } +} \ No newline at end of file diff --git a/161/history_text.txt b/161/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d53beb0a3abeec49e96aedb96e5ad6454f9e9c25 --- /dev/null +++ b/161/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed G2 squamous cell carcinoma, which is growing transglottically and infiltrating on both sides, hence the indication for surgical treatment. \ No newline at end of file diff --git a/161/icd_codes.txt b/161/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/161/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/161/ops_codes.txt b/161/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5124c8060715cb125c3fc70620f0fac9ad0e0513 --- /dev/null +++ b/161/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] Myotomie M. constrictor pharyngis mit Pharyngotomie[5-299.01 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/161/patient_clinical_data.json b/161/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..60fe01c7572893cd6c778c16cdb3542623adfcdf --- /dev/null +++ b/161/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/161/patient_pathological_data.json b/161/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ad3deb0eee6331050194e8e3856c1b7e8a39d84b --- /dev/null +++ b/161/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "161", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.6", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.5 +} \ No newline at end of file diff --git a/161/surgery_description.txt b/161/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fec7e6072953c12fd07c3efae885d66e5891821 --- /dev/null +++ b/161/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Provox insertion diff --git a/161/surgery_report.txt b/161/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f5ecdf3af6749a411f1f0d396c0ec14453bd41f --- /dev/null +++ b/161/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia by the anesthesia colleagues. Then direct laryngoscopy with the small bore tube and confirmation of findings and indication by and insertion of a nasogastric tube. Sterile wiping and draping. Skin incision. Dissection of the subcutaneous tissue and the platysma and formation of a subplatysmal apron flap in the typical manner. First dissection of the prelaryngeal and pretracheal fatty tissue in the sense of a level VI neck dissection, followed by exposure and dissection of the prelaryngeal musculature. Exposure of the thyroid isthmus. Dissection of the thyroid gland and visualization of the anterior wall of the trachea. Identification of the hyoid bone. Skeletonization of the hyoid bone and transection of the inferior constrictor muscle along the thyroid cartilage from both sides. Opening of the trachea against the second tracheal ring and re-intubation. Dissection in the direction of the vallecula up to the mucosal level. Opening of the vallecula and exposure of the epiglottis. Disluxation of the epiglottis. Incision along the lateral edges of the epiglottis and along the aryepiglottic folds on both sides. Strict care is taken to maximally preserve the mucosa of the piriform sinus on both sides. The incision is made in the postcricoid area and the mucosa of the hypopharynx is pushed away from the laryngeal skeleton and further dissection between the oesophagus and the posterior wall of the trachea. The larynx is then completely removed. This reveals a large macroscopic safety margin. A frozen section of the postcricoid region and tracheal separation border is sent for frozen section and later assessed as free of carcinoma. Then neck dissection on the right side. Identification of the anterior border of the sternocleidomastoid muscle. Dissection along the jugular vein in a cranial direction. In the cranial section, identification of the accessorius nerve and sparing of the accessorius nerve. The hypoglossal nerve is also identified and spared here. Level II b is then removed. Slide the preparation below the accessorius nerve. Further placement of the preparation caudally with protection of the cervical plexus branches. Modified functional neck dissection Level II to IV is performed, followed by neck dissection on the left side. Here also dissection along the anterior border of the sternocleidomastoid muscle. Exposure and sparing of the accessorius nerve. Exposure of the posterior venter of the digaster muscle and exposure of the internal jugular vein as well as the vagus nerve and the common carotid artery. Dissection along the cervical vascular sheath from caudal to cranial. Successive removal of the posterior and anterior neck preparation while protecting the above-mentioned structures and the plexus branches. A tracheoesophageal fistula is then created and a Provox prosthesis size 10 is inserted approx. 1 cm caudal to the upper tracheal margin. Subsequent palpation of the esophageal entrance. This revealed a relatively wide esophageal entrance. A myotomy was performed on the left side to prevent subsequent narrowing. Adaptation of the tracheal free edge with the stoma and fixation with Ethibond suture. Irrigation of the wound area with hydrogen and Ringer. Hemostasis. Subcutaneous and skin suturing and completion of the procedure without complications. Note: Nasogastric tube until the 10th postoperative day, then perform an X-ray gruel swallow, if this is inconspicuous, then diet build-up. Continue antibiotics for a total of 1 week. \ No newline at end of file diff --git a/162/InvasionFront_CD3_block1_x1_y4_patient162_0.json b/162/InvasionFront_CD3_block1_x1_y4_patient162_0.json new file mode 100644 index 0000000000000000000000000000000000000000..15325bbedc13892f616ad51ba9bb888a7428c5f3 --- /dev/null +++ b/162/InvasionFront_CD3_block1_x1_y4_patient162_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4422.7, + "Centroid Y µm": 11568.9, + "Num Detections": 19790, + "Num Negative": 19169, + "Num Positive": 621, + "Positive %": 3.138, + "Num Positive per mm^2": 286.16 + } +} \ No newline at end of file diff --git a/162/InvasionFront_CD3_block1_x2_y4_patient162_1.json b/162/InvasionFront_CD3_block1_x2_y4_patient162_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dbeb904ef1c3f5ce4d0915e1f9ef41db1de3c398 --- /dev/null +++ b/162/InvasionFront_CD3_block1_x2_y4_patient162_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6921.3, + "Centroid Y µm": 11518.9, + "Num Detections": 14458, + "Num Negative": 14200, + "Num Positive": 258, + "Positive %": 1.784, + "Num Positive per mm^2": 125.23 + } +} \ No newline at end of file diff --git a/162/InvasionFront_CD8_block1_x1_y4_patient162_0.json b/162/InvasionFront_CD8_block1_x1_y4_patient162_0.json new file mode 100644 index 0000000000000000000000000000000000000000..60e48042ff9f5a1a0c0ab561825de855357c4c43 --- /dev/null +++ b/162/InvasionFront_CD8_block1_x1_y4_patient162_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4472.6, + "Centroid Y µm": 10119.6, + "Num Detections": 17719, + "Num Negative": 17207, + "Num Positive": 512, + "Positive %": 2.89, + "Num Positive per mm^2": 256.96 + } +} \ No newline at end of file diff --git a/162/InvasionFront_CD8_block1_x2_y4_patient162_1.json b/162/InvasionFront_CD8_block1_x2_y4_patient162_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f181cb29cf2baedf16462193e474d0f30f8b8c72 --- /dev/null +++ b/162/InvasionFront_CD8_block1_x2_y4_patient162_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6971.3, + "Centroid Y µm": 10219.6, + "Num Detections": 11321, + "Num Negative": 11200, + "Num Positive": 121, + "Positive %": 1.069, + "Num Positive per mm^2": 74.39 + } +} \ No newline at end of file diff --git a/162/TumorCenter_CD3_block1_x1_y6_patient162_0.json b/162/TumorCenter_CD3_block1_x1_y6_patient162_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b4ed0d94099955b05226a5d705f022f2c482d5e --- /dev/null +++ b/162/TumorCenter_CD3_block1_x1_y6_patient162_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 15441.8, + "Num Detections": 18042, + "Num Negative": 17078, + "Num Positive": 964, + "Positive %": 5.343, + "Num Positive per mm^2": 400.26 + } +} \ No newline at end of file diff --git a/162/TumorCenter_CD3_block1_x2_y6_patient162_1.json b/162/TumorCenter_CD3_block1_x2_y6_patient162_1.json new file mode 100644 index 0000000000000000000000000000000000000000..32d1acbd1ac9999902ac710fc83a79f7ea0cb367 --- /dev/null +++ b/162/TumorCenter_CD3_block1_x2_y6_patient162_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 15366.9, + "Num Detections": 16567, + "Num Negative": 13149, + "Num Positive": 3418, + "Positive %": 20.63, + "Num Positive per mm^2": 1425.7 + } +} \ No newline at end of file diff --git a/162/TumorCenter_CD8_block1_x1_y4_patient162_0.json b/162/TumorCenter_CD8_block1_x1_y4_patient162_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c4f2580f28f67bc7183ce1fe726e598575acb121 --- /dev/null +++ b/162/TumorCenter_CD8_block1_x1_y4_patient162_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 18740.1, + "Num Detections": 18216, + "Num Negative": 16677, + "Num Positive": 1539, + "Positive %": 8.449, + "Num Positive per mm^2": 720.4 + } +} \ No newline at end of file diff --git a/162/TumorCenter_CD8_block1_x2_y4_patient162_1.json b/162/TumorCenter_CD8_block1_x2_y4_patient162_1.json new file mode 100644 index 0000000000000000000000000000000000000000..08658c34a9cce499087c0619fd861f2f202124cc --- /dev/null +++ b/162/TumorCenter_CD8_block1_x2_y4_patient162_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8820.3, + "Centroid Y µm": 18790.1, + "Num Detections": 17504, + "Num Negative": 16785, + "Num Positive": 719, + "Positive %": 4.108, + "Num Positive per mm^2": 333.73 + } +} \ No newline at end of file diff --git a/162/history_text.txt b/162/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3a65a40d19eedcd6fcecef6960b8539bcf9e88a6 --- /dev/null +++ b/162/history_text.txt @@ -0,0 +1 @@ +Post-panendoscopy from <2016> with ablation of leukoplakia in the area of the right alveolar ridge and right anterior palatal arch. Histology revealed a carcinoma in situ on the right alveolar ridge and a G3 differentiated squamous cell carcinoma and carcinoma in situ on the right anterior palatal arch. Post-resection with intraoperative frozen section diagnostics was discussed at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/162/icd_codes.txt b/162/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6bc8e8f926f9743489c414b91aea1da8b785383d --- /dev/null +++ b/162/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des weichen Gaumens[C05.1 R] \ No newline at end of file diff --git a/162/ops_codes.txt b/162/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dcbe43236fe0b9eacef8483aa8abb693f3a08b0d --- /dev/null +++ b/162/ops_codes.txt @@ -0,0 +1 @@ +Gaumenbogenkarzinom-Resektion[5-272.1 ] Biopsie am Gaumen ohne Inzision[1-420.2 ] \ No newline at end of file diff --git a/162/patient_clinical_data.json b/162/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0cca45af358ce16b35de48548adc9570425019b6 --- /dev/null +++ b/162/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/162/patient_pathological_data.json b/162/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..597a8f937264a9af9bf18217625679c777c269cc --- /dev/null +++ b/162/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "162", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/162/surgery_description.txt b/162/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..386111ef151f88bf7436ece8b6910cefd464606e --- /dev/null +++ b/162/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy diff --git a/162/surgery_report.txt b/162/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3973d77d7ccf9e9553677a6ed7d4dca414e86622 --- /dev/null +++ b/162/surgery_report.txt @@ -0,0 +1 @@ +Team time out and induction of anesthesia by the anesthesia colleagues with intubation. Dental status determined. Insertion of the Mc Ivor oral spatula and exposure of the right oropharynx: A slightly rough, spherical protrusion with smooth mucosa, approx. 0.8 cm in diameter, can be seen in the area of the former ablation on the anterior right palatal arch. Laterocaudally, the alveolar ridge is somewhat exposed after previous surgery. In addition, there is a leukoplakia on the right posterior palatal arch, which was not present 4 weeks ago, measuring approx. 3 x 6 mm longitudinally oval. No other new mucosal abnormalities in the rest of the oropharynx. Infiltration of the anterior and posterior right palatal arch with local anesthesia, Ultracaine 2% with the addition of Suprarenin. Now excision biopsy of the leukoplakia on the right posterior palatal arch with a 5 mm safety margin using a scalpel and pointed scissors. Suture marking still in the surgical site at 12 o'clock (cranial) and at 9 o'clock (lateral). The frozen section examination according to the telephone announcement by the pathologists shows a 2 cm large carcinoma in situ in the resectate, whereby a marginal formation in the frozen section at 12 o'clock cannot be ruled out, thus recommendation for subsequent resection, which takes place later. First, the already planned resection on the anterior palatal arch on the right: with a safety margin of approx. 5 mm, the raised, rough mass is cut around with the scalpel and pointed scissors on a smooth mucosal surface. Here too, suture marking in the surgical site at 6 o'clock (caudal) and 9 o'clock (lateral). The required size of the resection results in a defect in the anterior palatal arch, which is later adapted. According to the pathology department, the frozen section examination shows an invasive carcinoma of 0.2 cm originating from the CIS, which forms the cranial margin and also a moderate degree of dysplasia laterally, whereby it cannot be clearly distinguished from the CIS in the frozen section. Therefore recommendation for resection here as well. Preoperative demonstration to the previous surgeon . Now case discussion with , also based on the tumor conference decision, see file. Now indication for subsequent resection at the above-mentioned sites in accordance with the pathological recommendation, this time for definitive histology as well as an additional biopsy on the left anterior palatal arch in macroscopically unremarkable conditions to clarify whether a carcinoma in situ is also present here in the current case of field carcinomatization. Then discussion at the tumor conference and no PEG placement today. Now follow-up resections: Posterior palatal arch on the right: cranial resection of an approx. 5 mm wide strip of mucosa using a scalpel and pointed scissors. This is marked with sutures in the operating theater, both medially and cranially. Send in for definitive histology. Right anterior palatal arch resection: resection of a 5 mm wide strip of mucosa using a scalpel and pointed scissors, covering the entire area from medial to cranial to laterocaudal, triple suture markings. Sketch/photo with all markings see file. Finally, the right anterior palatal arch is adapted into the wound bed with Vicryl 4-0. No bleeding. In addition, biopsy of the left anterior palatal arch. No bleeding. Finally, insertion of a nasogastric feeding tube due to the extensive resection defect in the right oropharynx. Position control under direct vision and auscultatory with air insufflation. The procedure was completed without complications. Conclusion: Post-resection of the anterior right palatal arch for invasive squamous cell carcinoma originating from a carcinoma in situ and excisional biopsy of the posterior right palatal arch for carcinoma in situ; frozen section control. An additional resection of both sites was performed and will be followed by definitive histology. In case of suspected field carcinoma, biopsy of the left anterior palatal arch in a pale mucosal area. Procedure: Discussion in the tumor conference of the definitive histologies of the frozen section and the post-resectates. A PEG was deliberately avoided (see above). A PEG should only be inserted if radiochemotherapy is definitely indicated. Nasogastric tube in the right oropharynx for 3-5 days depending on the findings. \ No newline at end of file diff --git a/163/InvasionFront_CD3_block17_x3_y12_patient163_0.json b/163/InvasionFront_CD3_block17_x3_y12_patient163_0.json new file mode 100644 index 0000000000000000000000000000000000000000..31f0d60d8de4b73242a3aa552ccdf1d4169db7b4 --- /dev/null +++ b/163/InvasionFront_CD3_block17_x3_y12_patient163_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10419.5, + "Centroid Y µm": 35056.4, + "Num Detections": 16805, + "Num Negative": 16485, + "Num Positive": 320, + "Positive %": 1.904, + "Num Positive per mm^2": 145.36 + } +} \ No newline at end of file diff --git a/163/InvasionFront_CD3_block17_x4_y12_patient163_1.json b/163/InvasionFront_CD3_block17_x4_y12_patient163_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef13619d317eab7824374229aba39423dafb4545 --- /dev/null +++ b/163/InvasionFront_CD3_block17_x4_y12_patient163_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 35181.4, + "Num Detections": 19494, + "Num Negative": 18844, + "Num Positive": 650, + "Positive %": 3.334, + "Num Positive per mm^2": 291.3 + } +} \ No newline at end of file diff --git a/163/InvasionFront_CD8_block17_x3_y12_patient163_0.json b/163/InvasionFront_CD8_block17_x3_y12_patient163_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b79813f1fa8fc836da11600739e3662a5a0fa0e --- /dev/null +++ b/163/InvasionFront_CD8_block17_x3_y12_patient163_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 29734.3, + "Num Detections": 17188, + "Num Negative": 17045, + "Num Positive": 143, + "Positive %": 0.832, + "Num Positive per mm^2": 63.65 + } +} \ No newline at end of file diff --git a/163/InvasionFront_CD8_block17_x4_y12_patient163_1.json b/163/InvasionFront_CD8_block17_x4_y12_patient163_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a8ba422447aacfffb8425d68564a00cb2f6457b1 --- /dev/null +++ b/163/InvasionFront_CD8_block17_x4_y12_patient163_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 29684.3, + "Num Detections": 17843, + "Num Negative": 17510, + "Num Positive": 333, + "Positive %": 1.866, + "Num Positive per mm^2": 141.92 + } +} \ No newline at end of file diff --git a/163/TumorCenter_CD3_block17_x3_y12_patient163_0.json b/163/TumorCenter_CD3_block17_x3_y12_patient163_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f536fa3c9a054215dfa8b5145a1b726352c5abbb --- /dev/null +++ b/163/TumorCenter_CD3_block17_x3_y12_patient163_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10644.4, + "Centroid Y µm": 29634.3, + "Num Detections": 16633, + "Num Negative": 16041, + "Num Positive": 592, + "Positive %": 3.559, + "Num Positive per mm^2": 282.46 + } +} \ No newline at end of file diff --git a/163/TumorCenter_CD3_block17_x4_y12_patient163_1.json b/163/TumorCenter_CD3_block17_x4_y12_patient163_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d45ad325a506d5af67a3e9b5327a33dd32c7f65 --- /dev/null +++ b/163/TumorCenter_CD3_block17_x4_y12_patient163_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12993.1, + "Centroid Y µm": 29609.3, + "Num Detections": 14937, + "Num Negative": 14737, + "Num Positive": 200, + "Positive %": 1.339, + "Num Positive per mm^2": 110.54 + } +} \ No newline at end of file diff --git a/163/TumorCenter_CD8_block17_x3_y12_patient163_0.json b/163/TumorCenter_CD8_block17_x3_y12_patient163_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1d77a1ef9bcb86ff2838ca44b74dcaf1d6690718 --- /dev/null +++ b/163/TumorCenter_CD8_block17_x3_y12_patient163_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 43377.0, + "Num Detections": 10945, + "Num Negative": 10826, + "Num Positive": 119, + "Positive %": 1.087, + "Num Positive per mm^2": 81.49 + } +} \ No newline at end of file diff --git a/163/TumorCenter_CD8_block17_x4_y12_patient163_1.json b/163/TumorCenter_CD8_block17_x4_y12_patient163_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9db4e5f00fa45e390919c5abc63fbbaf314a01e8 --- /dev/null +++ b/163/TumorCenter_CD8_block17_x4_y12_patient163_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 43352.0, + "Num Detections": 17985, + "Num Negative": 17929, + "Num Positive": 56, + "Positive %": 0.3114, + "Num Positive per mm^2": 24.54 + } +} \ No newline at end of file diff --git a/163/history_text.txt b/163/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/163/icd_codes.txt b/163/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/163/ops_codes.txt b/163/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/163/patient_clinical_data.json b/163/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e88529bb60338d9116c5dc31003fc1fe2b658f41 --- /dev/null +++ b/163/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/163/patient_pathological_data.json b/163/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0a3d0d2ca7c8ebf005de7fe151d2dc163d81f4c6 --- /dev/null +++ b/163/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "163", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/163/surgery_description.txt b/163/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c62eab376ab1ff99283c3d51adc9a28a3ca3599f --- /dev/null +++ b/163/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection in the context of extended Chordektomie Type Va diff --git a/163/surgery_report.txt b/163/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/164/InvasionFront_CD3_block17_x1_y5_patient164_0.json b/164/InvasionFront_CD3_block17_x1_y5_patient164_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a955a25315c5f9e8126c5a87da29c75d72f88e8 --- /dev/null +++ b/164/InvasionFront_CD3_block17_x1_y5_patient164_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 17440.8, + "Num Detections": 15638, + "Num Negative": 15436, + "Num Positive": 202, + "Positive %": 1.292, + "Num Positive per mm^2": 91.65 + } +} \ No newline at end of file diff --git a/164/InvasionFront_CD3_block17_x2_y5_patient164_1.json b/164/InvasionFront_CD3_block17_x2_y5_patient164_1.json new file mode 100644 index 0000000000000000000000000000000000000000..73924b682b4ef1da5b706a168c2435c25485a0e0 --- /dev/null +++ b/164/InvasionFront_CD3_block17_x2_y5_patient164_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 17490.7, + "Num Detections": 23997, + "Num Negative": 23224, + "Num Positive": 773, + "Positive %": 3.221, + "Num Positive per mm^2": 287.19 + } +} \ No newline at end of file diff --git a/164/InvasionFront_CD8_block17_x1_y5_patient164_0.json b/164/InvasionFront_CD8_block17_x1_y5_patient164_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9e6859035d84c3dd579d0524e51a3341460914b4 --- /dev/null +++ b/164/InvasionFront_CD8_block17_x1_y5_patient164_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 12743.3, + "Num Detections": 16730, + "Num Negative": 16630, + "Num Positive": 100, + "Positive %": 0.5977, + "Num Positive per mm^2": 39.49 + } +} \ No newline at end of file diff --git a/164/InvasionFront_CD8_block17_x2_y5_patient164_1.json b/164/InvasionFront_CD8_block17_x2_y5_patient164_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d8079454b1d97698ba8e88cfaf370208811b33ea --- /dev/null +++ b/164/InvasionFront_CD8_block17_x2_y5_patient164_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 12793.2, + "Num Detections": 23499, + "Num Negative": 22867, + "Num Positive": 632, + "Positive %": 2.689, + "Num Positive per mm^2": 240.88 + } +} \ No newline at end of file diff --git a/164/TumorCenter_CD3_block17_x1_y5_patient164_0.json b/164/TumorCenter_CD3_block17_x1_y5_patient164_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a321baae2b7e956a7e7a171c6c9bd0dd6d06b943 --- /dev/null +++ b/164/TumorCenter_CD3_block17_x1_y5_patient164_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 12343.5, + "Num Detections": 14460, + "Num Negative": 14275, + "Num Positive": 185, + "Positive %": 1.279, + "Num Positive per mm^2": 81.0 + } +} \ No newline at end of file diff --git a/164/TumorCenter_CD3_block17_x2_y5_patient164_1.json b/164/TumorCenter_CD3_block17_x2_y5_patient164_1.json new file mode 100644 index 0000000000000000000000000000000000000000..60487123ece841f946e714a60619eb8cfc774560 --- /dev/null +++ b/164/TumorCenter_CD3_block17_x2_y5_patient164_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 12443.4, + "Num Detections": 12714, + "Num Negative": 12454, + "Num Positive": 260, + "Positive %": 2.045, + "Num Positive per mm^2": 122.83 + } +} \ No newline at end of file diff --git a/164/TumorCenter_CD8_block17_x1_y5_patient164_0.json b/164/TumorCenter_CD8_block17_x1_y5_patient164_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0caee9caba6df4007ad655d2a298fe5ad62dbfe7 --- /dev/null +++ b/164/TumorCenter_CD8_block17_x1_y5_patient164_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6333.1, + "Centroid Y µm": 26292.1, + "Num Detections": 11172, + "Num Negative": 11069, + "Num Positive": 103, + "Positive %": 0.9219, + "Num Positive per mm^2": 50.71 + } +} \ No newline at end of file diff --git a/164/TumorCenter_CD8_block17_x2_y5_patient164_1.json b/164/TumorCenter_CD8_block17_x2_y5_patient164_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6b464aa388b5ac18eaf099c99ec3c440e6ebf77f --- /dev/null +++ b/164/TumorCenter_CD8_block17_x2_y5_patient164_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8845.3, + "Centroid Y µm": 26186.1, + "Num Detections": 10385, + "Num Negative": 10265, + "Num Positive": 120, + "Positive %": 1.156, + "Num Positive per mm^2": 67.1 + } +} \ No newline at end of file diff --git a/164/history_text.txt b/164/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2efc7a99d79bbca593aa9f3edae7061572d7ef2c --- /dev/null +++ b/164/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Histologically confirmed malignoma in the area of the left vocal fold. The extent could not be determined with certainty on CT. \ No newline at end of file diff --git a/164/icd_codes.txt b/164/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d5a4ba58017e823c2d50497d1cc2c9727b1706c --- /dev/null +++ b/164/icd_codes.txt @@ -0,0 +1 @@ +Stimmlippenkarzinom[C32.0 L] Struma nodosa euthyreot[E04.1 ] \ No newline at end of file diff --git a/164/ops_codes.txt b/164/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d686f3a4e8e5e3b467b18e31e623f04985434d19 --- /dev/null +++ b/164/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Laryngektomie[5-302.x ] Perkutane [Nadel-] Biopsie an der Schilddrüse[1-406.2 ] \ No newline at end of file diff --git a/164/patient_clinical_data.json b/164/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d0c139ec24f5a6f6bb05f4cd92b3e962ba73f7f9 --- /dev/null +++ b/164/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/164/patient_pathological_data.json b/164/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..831eac150bee82ec1b250957e6fc117f44ed1c55 --- /dev/null +++ b/164/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "164", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/164/surgery_description.txt b/164/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b546ab1c95e24668d9290f1e05a51c5999af3fa9 --- /dev/null +++ b/164/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngectomy, PE (Parathyroidectomy) thyroid gland diff --git a/164/surgery_report.txt b/164/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2278cf1e9e4313e51280a0e4f2a88a2791f1de33 --- /dev/null +++ b/164/surgery_report.txt @@ -0,0 +1 @@ +Initial consultation with the anesthesiologist. After a detailed discussion with the patient, indication for an external procedure if the glottic plane cannot be adjusted. Local anesthesia is administered prelaryngeally. Abjode, cover the surgical area. Zigzag incision in the median line of the forehead..................... is well ......................... Exposure of the infrahyoid musculature. Exposure of the linea alba. Dissection through LInea alba. Exposure of the thyroid condyle, exposure of the cricoid cartilage, exposure of the ligamentum conicum. Dissection of the ligamentum conicum. Opening of the thyroid cartilage in the median line and exposure of the inside of the larynx. With inconspicuous conditions in the area of the right larynx, a mass is seen which occupies the entire left vocal fold on the left side, whereby the anterior commissure is macroscopically tumor-free. Dorsally, the tumor extends to the tip of the arytenoid cartilage, but does not reach the posterior commissure. On palpation, the tumor is very voluminous. After injecting local anesthesia, the tumor is now inserted in the area of the anterior border of the thyroid cartilage on the left side. Exposure of the perichondrium. Pushing off the tumor with the perichondrium and careful dissection in the area of the inside of the larynx. The tumor is resected in the area of the morgue sinus and the entire subglottic slope. Careful dissection, particularly in the area of the posterior laryngeal sections, and removal of the tumor, including the vocal process of the arytenoid cartilage. As far as can be assessed intraoperatively, this very voluminous tumor can be completely removed in the healthy tissue, even if the dissection is certainly very narrow in the direction of the perichondrium. Careful hemostasis. Removal of numerous marginal samples, which are found to be tumor-free in the frozen section histology. Very difficult dissection overall due to the size of the tumor. However, as far as can be assessed intraoperatively, the tumor can be completely removed from the healthy tissue, so that no further measures are required at this time. However, this patient must undergo regular check-ups and must be informed accordingly. Now careful hemostasis. Closure of the thyroid cartilage by suturing after a total of 4 perforations of the thyroid cartilage. Reconstruction of the ligamentum conicum. Insertion of a flap. Wound closure in layers. Finally, a coarse needle biopsy of the left thyroid nodule is performed under sonographic control. Exposure of the thyroid nodule and corresponding coarse needle biopsy. Finally, a gastric tube is inserted into the patient. Completion of the procedure. Final consultation with the anesthetist. Very difficult dissection conditions due to the anatomy and size of the tumor. Close monitoring is absolutely essential. \ No newline at end of file diff --git a/165/InvasionFront_CD3_block16_x5_y7_patient165_0.json b/165/InvasionFront_CD3_block16_x5_y7_patient165_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b733c8a778baca50f1aae05556b259cb944e381e --- /dev/null +++ b/165/InvasionFront_CD3_block16_x5_y7_patient165_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16698.5, + "Centroid Y µm": 22084.9, + "Num Detections": 21057, + "Num Negative": 20806, + "Num Positive": 251, + "Positive %": 1.192, + "Num Positive per mm^2": 100.43 + } +} \ No newline at end of file diff --git a/165/InvasionFront_CD3_block16_x6_y7_patient165_1.json b/165/InvasionFront_CD3_block16_x6_y7_patient165_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b73131ecea623239dafef0b9538664d675dd37fc --- /dev/null +++ b/165/InvasionFront_CD3_block16_x6_y7_patient165_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19169.3, + "Centroid Y µm": 22133.3, + "Num Detections": 20992, + "Num Negative": 20752, + "Num Positive": 240, + "Positive %": 1.143, + "Num Positive per mm^2": 100.66 + } +} \ No newline at end of file diff --git a/165/InvasionFront_CD8_block16_x5_y7_patient165_0.json b/165/InvasionFront_CD8_block16_x5_y7_patient165_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fad438cbb9a92c4e854156d592c4224b2fd99cba --- /dev/null +++ b/165/InvasionFront_CD8_block16_x5_y7_patient165_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 17415.8, + "Num Detections": 22781, + "Num Negative": 22485, + "Num Positive": 296, + "Positive %": 1.299, + "Num Positive per mm^2": 115.17 + } +} \ No newline at end of file diff --git a/165/InvasionFront_CD8_block16_x6_y7_patient165_1.json b/165/InvasionFront_CD8_block16_x6_y7_patient165_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0f901e245ca54bca287354db86e8368400d0e619 --- /dev/null +++ b/165/InvasionFront_CD8_block16_x6_y7_patient165_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 17490.7, + "Num Detections": 22783, + "Num Negative": 22301, + "Num Positive": 482, + "Positive %": 2.116, + "Num Positive per mm^2": 185.57 + } +} \ No newline at end of file diff --git a/165/TumorCenter_CD3_block16_x5_y7_patient165_0.json b/165/TumorCenter_CD3_block16_x5_y7_patient165_0.json new file mode 100644 index 0000000000000000000000000000000000000000..64764f700105011e848c8de4fc4d91f4edeffdcf --- /dev/null +++ b/165/TumorCenter_CD3_block16_x5_y7_patient165_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 18265.3, + "Num Detections": 21666, + "Num Negative": 20109, + "Num Positive": 1557, + "Positive %": 7.186, + "Num Positive per mm^2": 662.3 + } +} \ No newline at end of file diff --git a/165/TumorCenter_CD3_block16_x6_y7_patient165_1.json b/165/TumorCenter_CD3_block16_x6_y7_patient165_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2dc070683346ff6fe3d051b044d1bc5b68f8476 --- /dev/null +++ b/165/TumorCenter_CD3_block16_x6_y7_patient165_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19339.8, + "Centroid Y µm": 18365.3, + "Num Detections": 26566, + "Num Negative": 24540, + "Num Positive": 2026, + "Positive %": 7.626, + "Num Positive per mm^2": 735.34 + } +} \ No newline at end of file diff --git a/165/TumorCenter_CD8_block16_x5_y7_patient165_0.json b/165/TumorCenter_CD8_block16_x5_y7_patient165_0.json new file mode 100644 index 0000000000000000000000000000000000000000..929a0f115ab387d5b6cc2dcbfc79c861ee3fe6ed --- /dev/null +++ b/165/TumorCenter_CD8_block16_x5_y7_patient165_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 18015.5, + "Num Detections": 24804, + "Num Negative": 23405, + "Num Positive": 1399, + "Positive %": 5.64, + "Num Positive per mm^2": 537.42 + } +} \ No newline at end of file diff --git a/165/TumorCenter_CD8_block16_x6_y7_patient165_1.json b/165/TumorCenter_CD8_block16_x6_y7_patient165_1.json new file mode 100644 index 0000000000000000000000000000000000000000..491e4574b5d10d2424bfbe2ac8c596a4d7689287 --- /dev/null +++ b/165/TumorCenter_CD8_block16_x6_y7_patient165_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 18040.4, + "Num Detections": 26515, + "Num Negative": 24497, + "Num Positive": 2018, + "Positive %": 7.611, + "Num Positive per mm^2": 741.8 + } +} \ No newline at end of file diff --git a/165/history_text.txt b/165/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/165/icd_codes.txt b/165/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ca0cc8595d0cb4489fb7ac7fbceb3755ecb57b8f --- /dev/null +++ b/165/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zunge, mehrere Teilbereiche überlappend[C02.8 ] Lymphknotenvergrößerung, umschrieben[R59.0 ] \ No newline at end of file diff --git a/165/ops_codes.txt b/165/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..38289eb7182d4a00d65195b76f7faed6c1fe8e78 --- /dev/null +++ b/165/ops_codes.txt @@ -0,0 +1 @@ +Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Glossektomie: Transoral: Rekonstruktion mit nicht vaskularisiertem Transplantat[5-252.01 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Anderer operativer Verschluss an Blutgefäßen: Arterien Kopf, extrakraniell, und Hals: A. carotis externa[5-389.03 R] \ No newline at end of file diff --git a/165/patient_clinical_data.json b/165/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..592792895edac18d1b3f878ab83203b2db408aee --- /dev/null +++ b/165/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/165/patient_pathological_data.json b/165/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8fb3465cc59219490e7457a455b895703c949478 --- /dev/null +++ b/165/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "165", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/165/surgery_description.txt b/165/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0be66eb6cd81c92f6e20247419ab2e1b7f55c974 --- /dev/null +++ b/165/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/165/surgery_report.txt b/165/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a6bde33c5ead538713cce2ad1f442a4b6d004865 --- /dev/null +++ b/165/surgery_report.txt @@ -0,0 +1 @@ +After intubation by the anesthesia colleagues, start with PEG insertion: Entering the stomach under continuous air insufflation. Careful diaphanoscopy and air insufflation. PEG placement in the usual manner without complications. Now start with endoscopy. Entry with the Kleinsasser C-tube and inspection of the pharynx. A coarse, verrucous, already histologically confirmed tumor formation can be seen on the right side at the dorsal edge of the tongue at the junction of the glossotonsillar groove and at this point also radiating into the right base of the tongue. The palatine tonsil is not reached clinically. The midline is far away on palpation. The base of the tongue is infiltrated on the right side in the upper third about 2 cm cranial to the vallecula. Now the remaining hypopharynx, the vallecula, the epiglottis and the endolarynx are reflected. Inconspicuous conditions here. Then adjust the tongue with the self-retaining retractor and rein suture. Determination of the resection margins, which are clinically clearly in the healthy area. Then resection of the tongue tumor with the electric needle and in between with bipolar coagulation and scissors. The tumor preparation can be resected en bloc. The lingual artery does not have to be resected and the hypoglossal nerve is not exposed. The tumor specimen is now marked with sutures and is then sent to the frozen section. The medial edge, the lateral edge and the base of the tongue are each thread-marked. During the operation, the pathology department informs the surgeon that the specimen has been resected R0. Now hemostasis with the bipolar forceps. Laterally, it can be seen that a part of the palatine tonsil is also removed in the sense of a generous resection. Precise hemostasis here. Subsequent insertion of hydrogen swabs and turning to neck dissection on the right. Ultrasonographic status here cN2b ............2. Now instillation of 10 ml xylocaine without adrenaline in the area of the anterior edge of the sternocleidomastoid. Abjode, sterile draping and skin incision. Cut through the subcutaneous tissue and the platysma. Ligation of the external jugular vein and transection of the same. Now expose the anterior border of the sternocleidomastoid muscle, the internal jugular vein and the common carotid artery as well as the vagus nerve. It can now be seen that the cranial accessorius nerve extends into the neck metastasis at level 2. This metastasis virtually fills the upper accessorius triangle. The decision was made to resect the accessory nerve and to partially resect the sternocleidomastoid muscle in this region. Sharp detachment of the tumor metastasis from the upper accessorius triangle while sparing the vascular structures. This is successful. Now better view of the internal jugular vein. Sharp removal of the tumor conglomerate from the digaster venter posterior muscle. The V. is then exposed from caudal to cranial and finally the entire posterior neck preparation is removed while sparing the plexus branches. Now expose the hypoglossal nerve. Then complete the anterior neck by removing the capsule of the submandibular gland and anterior lymphatic tissue. Now expose the common carotid artery, the outlet of the internal carotid artery and the external carotid artery. Identify the superior thyroid artery, the lingual artery and the facial artery. The lingual artery is now effectively ligated. Subsequent irrigation with hydrogen and Ringer's solution, followed by hemostasis and placement of a 10-gauge Redon drain. Two-layer wound closure and repositioning to the opposite side. Here also instillation of 10 ml xylocaine and addition of adrenaline. Skin incision in the area of the anterior edge of the sternocleidomastoid. Exposure of the sternocleidomastoid muscle and the cranial accessorius nerve. The omohyoid muscle caudally, the cervical vascular sheath in the sense of the internal jugular vein, common carotid artery and vagus nerve. Now expose the accessorius nerve and finally free the upper accessorius triangle. Finally, detach the posterior neck preparation while sparing the plexus branches. Complete the anterior neck by removing the capsule of the submandibular gland and the remaining lymphatic tissue. The vagus nerve is also exposed. Subsequent irrigation with hydrogen and Ringer's solution. Insertion of a 10-gauge Redon drain and, after meticulous hemostasis, two-layer wound closure. Now repositioning for tracheotomy: modified Kocher collar incision, dissection of the subcutaneous tissue and cutting of prethyroid veins. Subsequent exposure of the cricoid cartilage and undermining of the thyroid isthmus. Removal of the latter after repositioning, exposure of the anterior wall of the trachea and insertion between the 2nd and 3rd tracheal cartilage. Creation of a Björk flap in ................. and epithelization of the tracheostoma. A 9-gauge tracheostomy tube is finally inserted. The patient receives Unacid 3 x 3 g intravenously. Finally, the swabs are again removed from the mouth area, blood is stopped again and the open wound edges are adapted using Vicryl sutures. \ No newline at end of file diff --git a/166/InvasionFront_CD3_block18_x1_y2_patient166_0.json b/166/InvasionFront_CD3_block18_x1_y2_patient166_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70d601ca5f0951da9714867d4d0178ade4ecff84 --- /dev/null +++ b/166/InvasionFront_CD3_block18_x1_y2_patient166_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4147.8, + "Centroid Y µm": 9220.1, + "Num Detections": 6535, + "Num Negative": 6497, + "Num Positive": 38, + "Positive %": 0.5815, + "Num Positive per mm^2": 35.31 + } +} \ No newline at end of file diff --git a/166/InvasionFront_CD3_block18_x2_y2_patient166_1.json b/166/InvasionFront_CD3_block18_x2_y2_patient166_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a2b01371afa54bbf9dfbc3bdd2a92e5b4b4506af --- /dev/null +++ b/166/InvasionFront_CD3_block18_x2_y2_patient166_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7071.3, + "Centroid Y µm": 9220.1, + "Num Detections": 16189, + "Num Negative": 15625, + "Num Positive": 564, + "Positive %": 3.484, + "Num Positive per mm^2": 270.1 + } +} \ No newline at end of file diff --git a/166/InvasionFront_CD8_block18_x1_y2_patient166_0.json b/166/InvasionFront_CD8_block18_x1_y2_patient166_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6af5ae5da64f16898a7ef15b300b64b161743b8b --- /dev/null +++ b/166/InvasionFront_CD8_block18_x1_y2_patient166_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4254.9, + "Centroid Y µm": 13081.9, + "Num Detections": 19863, + "Num Negative": 16372, + "Num Positive": 3491, + "Positive %": 17.58, + "Num Positive per mm^2": 1429.2 + } +} \ No newline at end of file diff --git a/166/InvasionFront_CD8_block18_x2_y2_patient166_1.json b/166/InvasionFront_CD8_block18_x2_y2_patient166_1.json new file mode 100644 index 0000000000000000000000000000000000000000..36890e33e5963bb109b943e3f5558a56d6a750e3 --- /dev/null +++ b/166/InvasionFront_CD8_block18_x2_y2_patient166_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6952.9, + "Centroid Y µm": 13085.1, + "Num Detections": 19294, + "Num Negative": 18399, + "Num Positive": 895, + "Positive %": 4.639, + "Num Positive per mm^2": 396.72 + } +} \ No newline at end of file diff --git a/166/TumorCenter_CD3_block18_x1_y2_patient166_0.json b/166/TumorCenter_CD3_block18_x1_y2_patient166_0.json new file mode 100644 index 0000000000000000000000000000000000000000..05a0c12615e4c10ac12c3b74751b1a1a01c5b19b --- /dev/null +++ b/166/TumorCenter_CD3_block18_x1_y2_patient166_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 5072.3, + "Num Detections": 28356, + "Num Negative": 28064, + "Num Positive": 292, + "Positive %": 1.03, + "Num Positive per mm^2": 108.39 + } +} \ No newline at end of file diff --git a/166/TumorCenter_CD3_block18_x2_y2_patient166_1.json b/166/TumorCenter_CD3_block18_x2_y2_patient166_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e810a1bddfa67797a53f89a426fa96267e32b74f --- /dev/null +++ b/166/TumorCenter_CD3_block18_x2_y2_patient166_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 4772.5, + "Num Detections": 27245, + "Num Negative": 27021, + "Num Positive": 224, + "Positive %": 0.8222, + "Num Positive per mm^2": 82.78 + } +} \ No newline at end of file diff --git a/166/TumorCenter_CD8_block18_x1_y2_patient166_0.json b/166/TumorCenter_CD8_block18_x1_y2_patient166_0.json new file mode 100644 index 0000000000000000000000000000000000000000..16a4180d74edd5e20886451b6027c3f183f1adda --- /dev/null +++ b/166/TumorCenter_CD8_block18_x1_y2_patient166_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 5547.1, + "Num Detections": 26487, + "Num Negative": 11167, + "Num Positive": 15320, + "Positive %": 57.84, + "Num Positive per mm^2": 5422.1 + } +} \ No newline at end of file diff --git a/166/TumorCenter_CD8_block18_x2_y2_patient166_1.json b/166/TumorCenter_CD8_block18_x2_y2_patient166_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aba3d61e5beb8ac6ad6b343dea04aaba434d9236 --- /dev/null +++ b/166/TumorCenter_CD8_block18_x2_y2_patient166_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 5247.2, + "Num Detections": 25832, + "Num Negative": 9511, + "Num Positive": 16321, + "Positive %": 63.18, + "Num Positive per mm^2": 5724.4 + } +} \ No newline at end of file diff --git a/166/history_text.txt b/166/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1fa3c6ec7cce5ccc487951a5ca04a1b37e451264 --- /dev/null +++ b/166/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: After a laryngeal carcinoma mainly on the left side, a tumor now appears on the right side 12 years after the initial diagnosis on the left. Histologically, this tumor was found to be a squamous cell carcinoma. As a result, the decision was made to resect part of the larynx from the outside due to the difficulty in adjusting it. It is noteworthy in the case history that the tumor was also treated in 2006 with a partial laryngectomy from the outside. \ No newline at end of file diff --git a/166/icd_codes.txt b/166/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4a9370e80708c773464060031b94c478294fde5a --- /dev/null +++ b/166/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Supraglottis[C32.1 R] \ No newline at end of file diff --git a/166/ops_codes.txt b/166/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dff177eb8da18afbce99e9f2df4b59384f52331d --- /dev/null +++ b/166/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] \ No newline at end of file diff --git a/166/patient_clinical_data.json b/166/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e8ff35834f31596c3f29a61e9564a421d391f164 --- /dev/null +++ b/166/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/166/patient_pathological_data.json b/166/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8d3fc9bd65218328b03259ff0ec0d565b8476b1a --- /dev/null +++ b/166/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "166", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/166/surgery_description.txt b/166/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..612a816e5642377db7ee4b2d33469bdad279d750 --- /dev/null +++ b/166/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection diff --git a/166/surgery_report.txt b/166/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..54b70a36b248ec7a8d440095011b396ac9a1f790 --- /dev/null +++ b/166/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Local anesthesia is administered prelaryngeally in the soft tissues of the neck. Ablation and covering of the surgical area. Re-entry into the old scar, which is very difficult due to scarring changes. Exposure of the laryngeal framework, exposure of the thyroid cartilage, exposure of the cricoid cartilage. The ligamentum conicum is largely ossified. Dissect the scar tissue from the thyroid cartilage and open the thyroid cartilage with the wheel in the median line. Opening of the larynx by insertion of a spreader. The tumor can be seen in the area of the right larynx. The tumor is located on the vocal fold. The resection areas of the trial biopsy are also visible. After exposure of the tumor, resection of the tumor, in which the inner perichondrium of the thyroid cartilage is removed and the surface of the vocal fold is also resected. The entire supraglottic region up to the petiolus of the epiglottis and laterally beyond on the right are successively resected, whereby the arytenoid cartilage is skeletonized. This results in a partial laryngeal resection, which includes in particular the supraglottic region up to the aryepiglottic fold. Parts of the aryepiglottic fold are also resected. Removal of marginal samples after the preparation has also been marked. This shows that isolated tumor parts are still detectable on the vocal fold surface. A resection is performed in the area of the vocal fold and the vocal process, the arytenoid cartilage. Corresponding marginal samples are taken and then found to be tumor-free in the frozen section examination. Careful hemostasis. The vocal fold is readapted on the front right at the anterior commissure to create a newly shaped vocal fold after approx. 50% of the volume of the vocalis muscle and the vocal ligament has been resected. Closure of the thyroid cartilage after drilling appropriate holes. Wound closure in layers. Insertion of a flap. Application of a pressure bandage. Final consultation with the anesthetist. Postoperatively, particular attention must be paid to the patient's swallowing function. Close follow-up examinations are absolutely essential. Overall, very difficult surgical conditions due to the pre-resection. Note: Close inspection of the left larynx revealed no pathological findings. \ No newline at end of file diff --git a/167/InvasionFront_CD3_block3_x1_y2_patient167_0.json b/167/InvasionFront_CD3_block3_x1_y2_patient167_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f6b1934d0c9288d7cee2f10d239b1aad6da68e5 --- /dev/null +++ b/167/InvasionFront_CD3_block3_x1_y2_patient167_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 8520.5, + "Num Detections": 16436, + "Num Negative": 16212, + "Num Positive": 224, + "Positive %": 1.363, + "Num Positive per mm^2": 107.27 + } +} \ No newline at end of file diff --git a/167/InvasionFront_CD3_block3_x2_y2_patient167_1.json b/167/InvasionFront_CD3_block3_x2_y2_patient167_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1672c93a59db74bca0d216f9b640af28afda8621 --- /dev/null +++ b/167/InvasionFront_CD3_block3_x2_y2_patient167_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8995.2, + "Centroid Y µm": 9095.2, + "Num Detections": 16468, + "Num Negative": 16094, + "Num Positive": 374, + "Positive %": 2.271, + "Num Positive per mm^2": 183.55 + } +} \ No newline at end of file diff --git a/167/InvasionFront_CD8_block3_x1_y2_patient167_0.json b/167/InvasionFront_CD8_block3_x1_y2_patient167_0.json new file mode 100644 index 0000000000000000000000000000000000000000..40370bd8d5f50a8fcb3266b51b73f05d426d1b6d --- /dev/null +++ b/167/InvasionFront_CD8_block3_x1_y2_patient167_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5145.0, + "Centroid Y µm": 5060.8, + "Num Detections": 10854, + "Num Negative": 10727, + "Num Positive": 127, + "Positive %": 1.17, + "Num Positive per mm^2": 57.12 + } +} \ No newline at end of file diff --git a/167/InvasionFront_CD8_block3_x2_y2_patient167_1.json b/167/InvasionFront_CD8_block3_x2_y2_patient167_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d4b403f3dc2e4d647753b90f544437909b59cfcf --- /dev/null +++ b/167/InvasionFront_CD8_block3_x2_y2_patient167_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7750.0, + "Centroid Y µm": 5053.3, + "Num Detections": 13233, + "Num Negative": 12534, + "Num Positive": 699, + "Positive %": 5.282, + "Num Positive per mm^2": 302.08 + } +} \ No newline at end of file diff --git a/167/TumorCenter_CD3_block3_x1_y2_patient167_0.json b/167/TumorCenter_CD3_block3_x1_y2_patient167_0.json new file mode 100644 index 0000000000000000000000000000000000000000..710605fbce13fb4fac8d455b1cc30f4c5a4037df --- /dev/null +++ b/167/TumorCenter_CD3_block3_x1_y2_patient167_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3504.6, + "Centroid Y µm": 11079.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/167/TumorCenter_CD3_block3_x2_y2_patient167_1.json b/167/TumorCenter_CD3_block3_x2_y2_patient167_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ba3f323a54b661e3d303e2b23d60a06233863440 --- /dev/null +++ b/167/TumorCenter_CD3_block3_x2_y2_patient167_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6384.9, + "Centroid Y µm": 10912.8, + "Num Detections": 16828, + "Num Negative": 15375, + "Num Positive": 1453, + "Positive %": 8.634, + "Num Positive per mm^2": 700.28 + } +} \ No newline at end of file diff --git a/167/TumorCenter_CD8_block3_x1_y2_patient167_0.json b/167/TumorCenter_CD8_block3_x1_y2_patient167_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cb8d1f9ff2406f336b74e8b792d4809ab5779c9f --- /dev/null +++ b/167/TumorCenter_CD8_block3_x1_y2_patient167_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4922.4, + "Centroid Y µm": 6621.5, + "Num Detections": 15753, + "Num Negative": 15415, + "Num Positive": 338, + "Positive %": 2.146, + "Num Positive per mm^2": 151.09 + } +} \ No newline at end of file diff --git a/167/TumorCenter_CD8_block3_x2_y2_patient167_1.json b/167/TumorCenter_CD8_block3_x2_y2_patient167_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd865f454ed6836f88ad15b743a245cebaf241b6 --- /dev/null +++ b/167/TumorCenter_CD8_block3_x2_y2_patient167_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7621.0, + "Centroid Y µm": 6671.5, + "Num Detections": 17779, + "Num Negative": 17322, + "Num Positive": 457, + "Positive %": 2.57, + "Num Positive per mm^2": 189.24 + } +} \ No newline at end of file diff --git a/167/history_text.txt b/167/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/167/icd_codes.txt b/167/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa53eb8be9331d2518fcb354f682f2ba6ca6ca6c --- /dev/null +++ b/167/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] Halslymphknotenmetastasen[C77.0 L] \ No newline at end of file diff --git a/167/ops_codes.txt b/167/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22459b37a3c5467ccf2112bd3f36dc44359f76c7 --- /dev/null +++ b/167/ops_codes.txt @@ -0,0 +1 @@ +Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Zungentumorexzision[5-250.2 ] Exzision Tonsillentumor[5-289.x ] Weichgaumenteilresektion[5-272.1 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] sonstige[5-295.0x ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Wechsel eines vaskulären Implantates[5-394.3 ] Selektive Neck dissection in 4 Regionen[5-403.03 R] Selektive Neck dissection in 5 Regionen[5-403.04 L] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 L] \ No newline at end of file diff --git a/167/patient_clinical_data.json b/167/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..14cbc8ef8bf7444a3267162d10df454ef98e6acc --- /dev/null +++ b/167/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/167/patient_pathological_data.json b/167/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6c7bbd48093040bfd23c30cffbc714a612c48d80 --- /dev/null +++ b/167/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "167", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 23.0 +} \ No newline at end of file diff --git a/167/surgery_description.txt b/167/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/167/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/167/surgery_report.txt b/167/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..46c0ba51d3b3f732f493c559c78b20a14afcbe33 --- /dev/null +++ b/167/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by anesthesia colleagues. Intubation transnasally by the anesthesia colleagues. Sterile washing and draping. First inspection of the tumor region. The tumor is located in the area of the left edge of the tongue, extends to the base of the tongue and infiltrates two thirds of the tongue, especially in the base of the tongue area, extends to the floor of the mouth as well as to the soft palate and the tonsil region and oropharyngeal side wall on the left. The tumor is first resected transorally, in the area of the edge of the tongue and the floor of the mouth. The tumor must then be moved transcervically, as there is no longer an adequate overview. To do this, make a skin incision 2.5 transverse fingers below the lower jaw in a skin fold. Expose the platysma. Separation of the platysma. Perform the neck dissection on the left in levels II a to V a. Form a platysmal flap cranially and caudally. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the cervical vascular sheath and the submandibular gland. Locating and exposing the nervus accessorius and free preparation of the internal jugular vein and facial vein. Clearing out the neck levels II a to V a, while sparing the plexus branches. Level II contains several enlarged metastases that are resected en bloc. Exposure of the vessels, in particular the lingual artery and the superior thyroid artery. The arterial vessels themselves are quite narrow and have an encrusted arterial wall. Continuation of the tumor resection. To do this, remove the submandibular gland and cut through the digastric muscle. This automatically leads to the area of the oral cavity. The tumor can now be further resected from the transcervical area and finally removed transcervically using the pull-through technique. This results in a very large pharyngeal defect and at least two thirds of the tongue is removed at the base of the tongue. The lingual nerve and the lingual artery can no longer be spared on the left side, but are completely present on the right side. Neck dissection on the right by and parallel lifting of the radialis graft. Neck dissection right level II a to V a. Skin incision in a transverse skin fold 2.5 cm below the mandibular branch. Exposure of the platysma. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the submandibular gland and the cervical vascular sheath. Exposure of the digastric muscle. Dissection of the jugular vein. Exposure of the vagus nerve and the accessorius nerve. Clearing of neck levels II a to V a, while sparing the plexus branches. Several lymph nodes are removed, which do not look suspicious on all sides. Insertion of a Redon drain and two-layer wound closure. Lifting of the radialis graft. First marking of the graft. Applying the tourniquet and cutting around the graft. Exposure of the brachioradialis muscle. Exposure of the cephalic vein and the vein star in the crook of the elbow. Then expose the superficial ramus, the radial nerve and its subdivision. All branches can be spared. Exposure of the radial artery with the accompanying vessels. Ligation and transection of the radial artery. Detachment of the graft from the tendon bed and preparation of the pedicle up to the crook of the elbow. A vein is lifted from the superficial system and a vein including the venous confluence from the deep system. Deposition of the graft and suturing of the forearm in the usual manner. Split skin was taken from the right thigh to cover the defect on the forearm and covered using a compress and swab suturing technique. A dorsal forearm splint was applied and the arm attached. In the meantime, the graft is fitted three-dimensionally into the defect. Suturing is extremely difficult due to the small mouth opening and the severe swelling. Ultimately, the graft is successfully fitted in such a way that both the soft palate and the floor of the mouth are reconstructed and the base of the tongue, the edge of the tongue and the side wall of the oropharynx are reconstructed using the same graft and a special folding technique. Now turn to the vascular anastomosis. First attempt to connect the arterial anastomosis to the stump of the lingual artery. This is initially successful and the venous anastomoses are also couplerized in the usual manner, however, due to the high catecholamine consumption caused by the anaesthesia, spasticity occurs in the arterial region, so that even after repeated irrigation and waiting, there is no longer any arterial perfusion in the graft area. The arterial anastomosis is therefore opened and it becomes clear that the lingual artery in the donor area is completely spastic and there is no longer sufficient blood flow. Therefore, the lingual artery is ligated and the superior thyroid artery is exposed and prepared. This is now connected to the radial artery so that sufficient transplant perfusion can ultimately be achieved under difficult circumstances. Insertion of a Redon drain and two-layer wound closure and completion of the procedure. The patient goes to the intensive care unit intubated and ventilated. Please continue antibiotics for 24 hours and 500 units of heparin per hour for 5 days due to the difficult anastomosis conditions. Flap checks according to the usual schedule and presentation of the patient to the tumor conference after receipt of the histology. \ No newline at end of file diff --git a/168/InvasionFront_CD3_block17_x3_y9_patient168_0.json b/168/InvasionFront_CD3_block17_x3_y9_patient168_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f903b03024a22b992a2bbbf5c063f85e37ee8125 --- /dev/null +++ b/168/InvasionFront_CD3_block17_x3_y9_patient168_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10669.4, + "Centroid Y µm": 27735.3, + "Num Detections": 16648, + "Num Negative": 16581, + "Num Positive": 67, + "Positive %": 0.4025, + "Num Positive per mm^2": 34.05 + } +} \ No newline at end of file diff --git a/168/InvasionFront_CD3_block17_x4_y9_patient168_1.json b/168/InvasionFront_CD3_block17_x4_y9_patient168_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7c851d2cb9f69d1fe28d079a5489e75dab9ad786 --- /dev/null +++ b/168/InvasionFront_CD3_block17_x4_y9_patient168_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13342.9, + "Centroid Y µm": 27760.3, + "Num Detections": 15509, + "Num Negative": 15424, + "Num Positive": 85, + "Positive %": 0.5481, + "Num Positive per mm^2": 48.58 + } +} \ No newline at end of file diff --git a/168/InvasionFront_CD8_block17_x3_y9_patient168_0.json b/168/InvasionFront_CD8_block17_x3_y9_patient168_0.json new file mode 100644 index 0000000000000000000000000000000000000000..af71de1ade7e43cd0fa17c83cd81bfc0af881318 --- /dev/null +++ b/168/InvasionFront_CD8_block17_x3_y9_patient168_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 22613.0, + "Num Detections": 16345, + "Num Negative": 16316, + "Num Positive": 29, + "Positive %": 0.1774, + "Num Positive per mm^2": 14.69 + } +} \ No newline at end of file diff --git a/168/InvasionFront_CD8_block17_x4_y9_patient168_1.json b/168/InvasionFront_CD8_block17_x4_y9_patient168_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cc518796a032b44790da0550c7717015e571dec9 --- /dev/null +++ b/168/InvasionFront_CD8_block17_x4_y9_patient168_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 22613.0, + "Num Detections": 14242, + "Num Negative": 14165, + "Num Positive": 77, + "Positive %": 0.5407, + "Num Positive per mm^2": 43.33 + } +} \ No newline at end of file diff --git a/168/TumorCenter_CD3_block17_x3_y9_patient168_0.json b/168/TumorCenter_CD3_block17_x3_y9_patient168_0.json new file mode 100644 index 0000000000000000000000000000000000000000..739f753745cbdcadcfe2fd14af91e7e46df3aa02 --- /dev/null +++ b/168/TumorCenter_CD3_block17_x3_y9_patient168_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 22563.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/168/TumorCenter_CD3_block17_x4_y9_patient168_1.json b/168/TumorCenter_CD3_block17_x4_y9_patient168_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ea5883ae39c4af6fa2bed1911bc38441d295caab --- /dev/null +++ b/168/TumorCenter_CD3_block17_x4_y9_patient168_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 22413.1, + "Num Detections": 15325, + "Num Negative": 15112, + "Num Positive": 213, + "Positive %": 1.39, + "Num Positive per mm^2": 121.26 + } +} \ No newline at end of file diff --git a/168/TumorCenter_CD8_block17_x3_y9_patient168_0.json b/168/TumorCenter_CD8_block17_x3_y9_patient168_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d4af520922f899fbf56229766de8e41b97d1902 --- /dev/null +++ b/168/TumorCenter_CD8_block17_x3_y9_patient168_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 36030.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/168/TumorCenter_CD8_block17_x4_y9_patient168_1.json b/168/TumorCenter_CD8_block17_x4_y9_patient168_1.json new file mode 100644 index 0000000000000000000000000000000000000000..756d82690db28b5aeece828dfa8b5199f6fd22d8 --- /dev/null +++ b/168/TumorCenter_CD8_block17_x4_y9_patient168_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16491.3, + "Centroid Y µm": 35980.9, + "Num Detections": 7452, + "Num Negative": 7401, + "Num Positive": 51, + "Positive %": 0.6844, + "Num Positive per mm^2": 63.77 + } +} \ No newline at end of file diff --git a/168/history_text.txt b/168/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1f911b705ef8179cf893a9083de58279916a6f5d --- /dev/null +++ b/168/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma on the left. A sample was taken from the middle to dorsal left glottis. Invasive squamous cell carcinoma G3 was diagnosed. Further diagnostics revealed mobile arytenoid cartilage on both sides, particularly on the left, and cartilage infiltration could not be ruled out on CT, but this could not be clearly confirmed on ultrasound. Overall, detailed explanatory discussion with the patient. In any case, the patient wanted the operation to preserve the larynx. However, due to the location of the tumor dorsally in the arytenoid region and the extent of the tumor that could not be clearly determined during panendoscopy due to poor adjustability, the patient was also informed about the possibility of a laryngectomy. Patient is rather opposed to a laryngectomy and would only accept it in an extreme emergency. Requests partial laryngectomy. After a detailed discussion, the patient also accepts a possible swallowing disorder due to a partial laryngectomy in exchange for the possibility of initially preserving the residual larynx and then attempting to compensate for the swallowing disorder by means of swallowing exercises. Overall agreement to attempt partial laryngectomy, even accepting a possible long-term swallowing disorder. The patient only agrees to laryngectomy if it is oncologically impossible to preserve the larynx. Sonographic cN0 status. \ No newline at end of file diff --git a/168/icd_codes.txt b/168/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/168/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/168/ops_codes.txt b/168/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..38ce70fee6f9b4084c4bd334c81397c351755626 --- /dev/null +++ b/168/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 4 Regionen[5-403.30 L] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/168/patient_clinical_data.json b/168/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f4829148a2eb9b759575b02a0979f1de627697f9 --- /dev/null +++ b/168/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/168/patient_pathological_data.json b/168/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7bc1fc5783dcabf414b6353eb052ed9fb95bbdab --- /dev/null +++ b/168/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "168", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/168/surgery_description.txt b/168/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0af62d819317bc45d62cf306e599f56cfe8e49f7 --- /dev/null +++ b/168/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection, Left neck dissection, Tracheostomy creation diff --git a/168/surgery_report.txt b/168/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce1925d9767f622fff7d0589eec4c7c60af14cc6 --- /dev/null +++ b/168/surgery_report.txt @@ -0,0 +1 @@ +First orotracheal intubation by the anesthesia colleagues. The site is then covered as for a possible laryngectomy with neck dissection on both sides. This is followed by a Z-shaped incision and a small Kocher collar incision. The larynx is exposed via the Z-shaped incision. To do this, dissect through the subcutaneous tissue down to the infrahyoid musculature, which is split. Then dissect the perichondrium from right to left on the left side. Then split the larynx median. Entering the larynx anteriorly. The larynx is then inspected. The fibrin-covered area at the level of the arytenoid cartilage, where the sample had been taken and the G3 carcinoma had been confirmed, can be seen at the back. A macroscopic growth is extremely difficult to delineate with almost inconspicuous mucosa. Therefore, the resection was started slightly dorsal to the anterior part of the left vocal cord and immediately extended to the cartilage. This was because a cartilage infiltration could not be ruled out on CT, but this could not be clearly confirmed on ultrasound. Removal of the entire soft tissue from the cartilage below the perichondrium to the dorsal region of the arytenoid cartilage. Most of this is also resected. The posterior upper parts remain. Resection caudally up to the subglottic slope and cranially including parts of the pouch ligament. Dorsal removal of the largest parts of the arytenoid cartilage. The aryepiglottic fold is only slightly affected. The specimen is removed in toto and marked with sutures, especially dorsally and basally. A marginal sample is taken from the mucosa in the arytenoid region and soft tissue from the dorsal arytenoid region. The entire specimen and the 2 marginal samples are sent for frozen section. In the frozen section, the tumor is removed from the healthy area and the marginal samples are also healthy. Due to dysplastic extensions to the subglottic and anterior regions, it is recommended to take corresponding resections in these regions. Therefore, the remaining parts of the anterior left vocal cord up to the anterior commissure and the attached soft tissue are removed. A further mucosal sample is then taken from the entire subglottic area from anterior to posterior. No more dysplasia in the frozen section. Overall, including the marginal samples, R0 resection. This is followed by very careful hemostasis. A tracheotomy had already been performed before the tumor resection. For this purpose, a Kocher's collar incision was made slightly dorsally and after dissection through subcutaneous tissue, the infrahyoid musculature was pushed apart, the isthmus was cut and treated with puncture ligatures. After exposing the trachea, the 2nd/3rd intercartilaginous space is entered and a visor flap is created. This was then epithelialized. The tumor resection was then performed as described above. After creation of the R0 resection, very careful hemostasis and closure of the larynx. For this purpose, the remaining parts of the arytenoid cartilage were first sutured dorsally to the soft tissue of the arytenoid fold to improve stability. Then fixation of the remains of the anteriormost parts of the right vocal cord to the cartilage using 4-0 Vicryl single-button sutures. After making 3 drill holes, closure of the thyroid cartilage with 3-0 Vicryl single button sutures. Stable closure. Then close the ligamentum conicum with 4-0 Vicryl single button sutures. The left perichondrium soft tissue flap is then swung over around the laryngeal skeleton. This is sutured to the remaining soft tissue on the right side of the larynx with 4-0 Vicryl single button sutures so that the laryngeal skeleton is completely closed with soft tissue. Then suture the infrahyoid musculature. Suture of subcutaneous tissue. Insertion of a flap and skin suture. Subsequent completion of the epithelialization of the tracheostoma. Neck dissection left level II to IV: skin incision and dissection through the subcutaneous fatty tissue and dissection through the platysma. Dissection in a subplatysmal manner and discovery of the anterior border of the sternocleidomastoid muscle. The external jugular vein is ligated. Expose the accessorius nerve and spare it. Now locate the omohyoid muscle and follow it cranially. Expose the submandibular gland. Expose the gland and elevate the gland using Langenbeck to spare the marginal ramus of the facial nerve. Exposure of the posterior venter of the digastric muscle up to level II. Now also exposure of the cervical vascular nerve sheath and vagus nerve with preservation of all the structures mentioned. Now dissection of level IIb, here a relatively large mass in the sense of a lymph node is seen, which is successively dissected. Dissection in a caudal direction so that a total of levels IIa and b, level III and level IV are removed. Successive development and removal of the lateral neck preparation. The cervical plexus can be spared without any problems, also removal of level V. Further free preparation of the cervical sheath and development of the medial neck preparation while sparing the hypoglossal nerve. There is increased bleeding, not even after a Valsalva attempt, for this reason insertion of a Redon drainage and two-layer wound closure. Then reintubation, insertion of a 7 mm tracheal cannula. Insertion of a nasogastric tube to feed the patient. The procedure is then completed without complications. Patient admitted to intensive care unit for one night for postoperative monitoring. Nutrition initially for a few days via the nasogastric tube. Then carefully build up the diet. A swallowing disorder may well be present and may also be somewhat protracted. Therefore, if there are problems with swallowing, start swallowing training at an early stage. Overall, glottic carcinoma is difficult to diagnose cT1 to cT2 in terms of its extent with rather microscopic findings. Due to the tumor location and G3 stage, neck dissection level II to IV was performed on the left. Further procedure after receipt of the final histology. Then presentation at the interdisciplinary tumor conference. A follow-up MLE in 8-12 weeks seems sensible in any case. \ No newline at end of file diff --git a/169/InvasionFront_CD3_block14_x3_y1_patient169_0.json b/169/InvasionFront_CD3_block14_x3_y1_patient169_0.json new file mode 100644 index 0000000000000000000000000000000000000000..817546ca0f47df51ea6c665a180528bbbb650ddd --- /dev/null +++ b/169/InvasionFront_CD3_block14_x3_y1_patient169_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12493.4, + "Centroid Y µm": 6071.8, + "Num Detections": 20585, + "Num Negative": 16099, + "Num Positive": 4486, + "Positive %": 21.79, + "Num Positive per mm^2": 1747.2 + } +} \ No newline at end of file diff --git a/169/InvasionFront_CD3_block14_x4_y1_patient169_1.json b/169/InvasionFront_CD3_block14_x4_y1_patient169_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f217b5c2c8e4e04a8da14749452bb63317fa5f24 --- /dev/null +++ b/169/InvasionFront_CD3_block14_x4_y1_patient169_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15067.0, + "Centroid Y µm": 6121.8, + "Num Detections": 22125, + "Num Negative": 17677, + "Num Positive": 4448, + "Positive %": 20.1, + "Num Positive per mm^2": 1634.2 + } +} \ No newline at end of file diff --git a/169/InvasionFront_CD8_block14_x3_y1_patient169_0.json b/169/InvasionFront_CD8_block14_x3_y1_patient169_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee2bd85077291e1b76aa1efa22ccae8dca8b5280 --- /dev/null +++ b/169/InvasionFront_CD8_block14_x3_y1_patient169_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12118.6, + "Centroid Y µm": 2523.7, + "Num Detections": 20379, + "Num Negative": 17797, + "Num Positive": 2582, + "Positive %": 12.67, + "Num Positive per mm^2": 1053.7 + } +} \ No newline at end of file diff --git a/169/InvasionFront_CD8_block14_x4_y1_patient169_1.json b/169/InvasionFront_CD8_block14_x4_y1_patient169_1.json new file mode 100644 index 0000000000000000000000000000000000000000..22522062b7d05d7ead5b17633ff6ac8b7186df18 --- /dev/null +++ b/169/InvasionFront_CD8_block14_x4_y1_patient169_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14667.2, + "Centroid Y µm": 2473.7, + "Num Detections": 22356, + "Num Negative": 19531, + "Num Positive": 2825, + "Positive %": 12.64, + "Num Positive per mm^2": 1070.4 + } +} \ No newline at end of file diff --git a/169/TumorCenter_CD3_block14_x3_y1_patient169_0.json b/169/TumorCenter_CD3_block14_x3_y1_patient169_0.json new file mode 100644 index 0000000000000000000000000000000000000000..07e7b80afc5ea97144d8be7154e8f91942a95b1f --- /dev/null +++ b/169/TumorCenter_CD3_block14_x3_y1_patient169_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12493.4, + "Centroid Y µm": 2948.4, + "Num Detections": 19731, + "Num Negative": 13480, + "Num Positive": 6251, + "Positive %": 31.68, + "Num Positive per mm^2": 2473.2 + } +} \ No newline at end of file diff --git a/169/TumorCenter_CD3_block14_x4_y1_patient169_1.json b/169/TumorCenter_CD3_block14_x4_y1_patient169_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6ecd1b4c8ad8bfaf469e3239cf5a9ecf4550b3a --- /dev/null +++ b/169/TumorCenter_CD3_block14_x4_y1_patient169_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14992.1, + "Centroid Y µm": 3173.3, + "Num Detections": 22000, + "Num Negative": 18312, + "Num Positive": 3688, + "Positive %": 16.76, + "Num Positive per mm^2": 1434.8 + } +} \ No newline at end of file diff --git a/169/TumorCenter_CD8_block14_x3_y1_patient169_0.json b/169/TumorCenter_CD8_block14_x3_y1_patient169_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8aff0da4775e15fd60a8acd4d3831a12aff0ff00 --- /dev/null +++ b/169/TumorCenter_CD8_block14_x3_y1_patient169_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 3273.3, + "Num Detections": 19954, + "Num Negative": 15674, + "Num Positive": 4280, + "Positive %": 21.45, + "Num Positive per mm^2": 1693.3 + } +} \ No newline at end of file diff --git a/169/TumorCenter_CD8_block14_x4_y1_patient169_1.json b/169/TumorCenter_CD8_block14_x4_y1_patient169_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ce3c3aa232e1aef779fc34e05a4d8791c771f116 --- /dev/null +++ b/169/TumorCenter_CD8_block14_x4_y1_patient169_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 3398.2, + "Num Detections": 20925, + "Num Negative": 17134, + "Num Positive": 3791, + "Positive %": 18.12, + "Num Positive per mm^2": 1485.2 + } +} \ No newline at end of file diff --git a/169/history_text.txt b/169/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..756fb3a5f5e5d4cea85784f697957391ecb7662d --- /dev/null +++ b/169/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the area of the right tongue. Not crossing the midline. The above procedure is therefore indicated. \ No newline at end of file diff --git a/169/icd_codes.txt b/169/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/169/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/169/ops_codes.txt b/169/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..27a36d5cf4850827ae4c3377a060a57af5a68a01 --- /dev/null +++ b/169/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Entnahme freier Radialis-Lappen[5-858.23 L] Großflächige freie Vollhauttransplantation am Unterarm (Empfängerstelle)[5-902.68 L] Entnahme von Vollhaut zur Transplantation am Unterarm[5-901.18 L] Temporäre Tracheotomie[5-311.0 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] \ No newline at end of file diff --git a/169/patient_clinical_data.json b/169/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8684b9ddeb4c744763c1fe8d95a84bb679fd7dfa --- /dev/null +++ b/169/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 26, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/169/patient_pathological_data.json b/169/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8ab5615cb2734ecfa05fc6196c86202b844e6c56 --- /dev/null +++ b/169/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "169", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.7", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/169/surgery_description.txt b/169/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f4292f3f9c143bc28871fa7e697c2ad28e76a294 --- /dev/null +++ b/169/surgery_description.txt @@ -0,0 +1 @@ +Hemiglossectomy, Tracheotomy, Defect coverage, Bilateral neck dissection diff --git a/169/surgery_report.txt b/169/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f6a974c5480c8ffbc6eebc530d5a0c5ba0f7d5f4 --- /dev/null +++ b/169/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Consultation with the anesthetist. Subsequent transoral tumor resection: After appropriate preparation, insertion of the mouth retractors. Rein suture of the tip of the tongue and disluxation of the tongue. The tumor located on the right middle edge of the tongue is then resected with scissors in the sense of a hemiglossectomy and macroscopically far into the healthy tissue. Repeated careful hemostasis and bipolar coagulation and ligation of several larger arterial branches. The specimen is sent for frozen section histology diagnostics and is found to have been resected well within the healthy tissue. After completion of the tumor resection, measurement of the defect with a size of about 8 x 4 1/2 cm. Transition to neck dissection on both sides and elevation of the radial lobe graft from the left forearm. Subsequent repositioning for neck dissection on both sides and defect coverage. Sterile draping of all surgical areas. Injection of a total of 10 ml Ultracaine 1% with adrenaline per side of the neck. Neck dissection on the right: incision in a submandibular neck fold. Exposure of the sternocleidomastoid muscle, omohyoid muscle, digastric muscle and infrahyoid muscles. Visualization of the internal jugular vein, internal carotid artery, external carotid artery, visualization of the superior thyroid artery and facial artery. There is no adequate external jugular vein. However, there is a good facial artery with several outlets. Clearing of the lymph nodes level II to IV, including visualization of the cervical artery, vagus nerve, hypoglossal nerve and accessorius nerve. All nerves are exposed, dissected out and re-embedded. Several slightly enlarged lymph nodes, but none clearly positive. Neck dissection on the left side: This is performed in the same way as on the right side. Levels II to IV are removed in the same way. Some enlarged lymph nodes are also found here. The radial lobe graft is then removed. Removal of the radial lobe (): Measurement of the defect in the area of the oral cavity. After glossectomy, the defect is 8 x 4 cm. A spindle-shaped graft is drawn in the area of the forearm, palpation of the radial and ulnar arteries. Draw the cephalic vein from the proximal end of the graft in a curved line to the crook of the elbow, then make an incision in the opposite direction in the proximal part of the forearm approx. 7 x 3 cm so that after removal of the radial flap, full-thickness skin is obtained from the forearm and used to close the resulting defect in the radial flap. Now incise the skin using a 15 mm scalpel, cut through the skin and subcutaneous tissue to the proximal end of the flap. Expose the brachioradialis muscle and the flexor carpis radialis muscle. Exposure of the pedicle between the muscle bellies. Exposure of the V. mediana cubita, in the crook of the elbow exposure of the V. confluens, exposure of the V. cephalica. The cephalic vein is dissected so that it is integrated into the flap. After complete dissection of the vascular pedicle with 2 deep veins and the radial artery, the skin around the graft is incised. The flap is now dissected in such a way that the vascular pedicle is integrated medially or radially of the flexor carpi radialis. The radial artery is then exposed using clamps and wrapped around with lateral sutures. This tests whether the oxygenation decreases when the radial artery is squeezed. The findings are correct with a sufficient increase in flow through the ulnar artery, so that there is no drop in saturation when the radial artery is squeezed. The remaining flap is now incised, the superficial ramus of the radial nerve is exposed and preserved. The smallest branches that run to the flap are not preserved, but the main branch of the superficial ramus and radial nerve is preserved. All vessels are now exposed in the antecubital fossa and the flap is removed at the distal end. The radial artery is ligated using lateral sutures, the radial artery is removed proximally and the ulnar and brachial arteries are identified and spared. The interosseous artery is separated from the radial artery and integrated into the flap. The cephalic artery is removed proximal to the confluence so that the accompanying veins of the vascular pedicle, the confluent vein and the cephalic vein can be spared and integrated into the flap. The flap is now removed proximally. In the proximal area of the forearm, a spindle-shaped excision of skin is performed as described above and dissected away from the fatty tissue. A 7 x 3 cm full-thickness skin graft can now be sutured into the radial flap defect without difficulty. Proximally, the forearm is primarily closed, double-layered subcutaneous suture using 4-0 Vicryl and continuous skin suture using 5-0 Ethilon. The full-thickness skin is sutured with 4-0 Ethilon. Four small relief incisions are now made to prevent hematoma. Bepanthen ointment is then applied, compresses are sewn in and the arm is bandaged and a dorsal forearm splint is applied in the typical manner. Then incision of the radialis flap: First create a tunnel from the right side of the neck into the oral cavity area. To do this, cut the digastric muscle. Then removal of the submandibular gland. Careful protection and exposure, re-embedding of the lingual nerve. A 2-3 QF tunnel is created in the floor of the mouth. The radialis flap graft is then sutured into the defect with 3-0 Vicryl single button sutures. Tension-free and complete defect coverage. The stalk was previously passed through the tunnel into the neck area on the right side. Here the radial artery and the lingual artery, which is prepared, are used for anastomosis. After conditioning the vessels, suturing is performed using single button sutures 9-0 Ethilon. After opening the clamp, good arterial flow and good venous return. Subsequently, 2 outlets are exposed from the area of the accompanying vein of the radial artery, which have good venous flow. The branches of the cephalic vein have significantly poorer venous flow and are therefore clipped. The veins from the confluence area are anastomosed with 2 veins from the outlet of the facial vein using 2.5 mm and 2.0 mm couplers. Good venous flow after opening the clamps. Positive smear phenomenon. Inspection of the flap enorally, this shows good blood flow. Subsequent clipping of all still open venous outlets. Most careful hemostasis and irrigation. Then wound closure in layers with insertion of 2 flaps on the right side and a Redon drainage on the left side. Due to the swelling, an enoral decision was made to perform a small tracheostomy. Now tracheotomy: skin incision approx. 5 cm long 1 QF below the cricoid horizontally. Sharp cutting of the skin, subcutaneous tissue and platysma using a 15 mm scalpel. The infrahyoid musculature is now exposed. Entering the midline. Cut through the midline with scissors. Expose the thyroid gland. An Overholt clamp is used to enter between the cricoid and isthmus. The isthmus of the thyroid gland is easily bipolarized and severed. A small tracheotomy is then performed between the 2nd and 3rd tracheal cartilage clasp so that a 7-gauge cannula can be inserted. Mucocutaneous anastomosis is performed with Ethibond sutures in the typical manner. Completion of the procedure without complications. Subsequent completion of the procedure without complications. Flap vital at the end of the operation, wound conditions normal. Patient transferred to the intensive care unit on mechanical ventilation. Please continue antibiotics, which were started intraoperatively with Unacid, for 1 week postoperatively. Nutrition via the preoperatively inserted gastric tube for approx. 1 week to 10 days, then, depending on the clinical situation, diet build-up. Flap control according to the scheme for 5 days. Please run heparin perfusor 500 E/h for 5 days. Presentation of the patient at the interdisciplinary tumor conference after receipt of the final histology. \ No newline at end of file diff --git a/170/InvasionFront_CD3_block17_x3_y1_patient170_0.json b/170/InvasionFront_CD3_block17_x3_y1_patient170_0.json new file mode 100644 index 0000000000000000000000000000000000000000..55da58149e7f194c638350530be22817a8394775 --- /dev/null +++ b/170/InvasionFront_CD3_block17_x3_y1_patient170_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 7546.0, + "Num Detections": 22495, + "Num Negative": 19072, + "Num Positive": 3423, + "Positive %": 15.22, + "Num Positive per mm^2": 1301.3 + } +} \ No newline at end of file diff --git a/170/InvasionFront_CD3_block17_x4_y1_patient170_1.json b/170/InvasionFront_CD3_block17_x4_y1_patient170_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2773ab40529af96a9554585c4bf35703af13305 --- /dev/null +++ b/170/InvasionFront_CD3_block17_x4_y1_patient170_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 7546.0, + "Num Detections": 22174, + "Num Negative": 18749, + "Num Positive": 3425, + "Positive %": 15.45, + "Num Positive per mm^2": 1301.4 + } +} \ No newline at end of file diff --git a/170/InvasionFront_CD8_block17_x3_y1_patient170_0.json b/170/InvasionFront_CD8_block17_x3_y1_patient170_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e4a3afa31c279f6c83bdaaa6a60605c0675a5456 --- /dev/null +++ b/170/InvasionFront_CD8_block17_x3_y1_patient170_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11369.0, + "Centroid Y µm": 2873.5, + "Num Detections": 21981, + "Num Negative": 21850, + "Num Positive": 131, + "Positive %": 0.596, + "Num Positive per mm^2": 52.11 + } +} \ No newline at end of file diff --git a/170/InvasionFront_CD8_block17_x4_y1_patient170_1.json b/170/InvasionFront_CD8_block17_x4_y1_patient170_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aca6a2c0e27060ef95d56219c0b0b9eede1d9e32 --- /dev/null +++ b/170/InvasionFront_CD8_block17_x4_y1_patient170_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 2798.5, + "Num Detections": 22708, + "Num Negative": 22234, + "Num Positive": 474, + "Positive %": 2.087, + "Num Positive per mm^2": 182.84 + } +} \ No newline at end of file diff --git a/170/TumorCenter_CD3_block17_x3_y1_patient170_0.json b/170/TumorCenter_CD3_block17_x3_y1_patient170_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b108802a047b37a293f5f3261ed48224b466e42 --- /dev/null +++ b/170/TumorCenter_CD3_block17_x3_y1_patient170_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 2573.6, + "Num Detections": 22248, + "Num Negative": 17883, + "Num Positive": 4365, + "Positive %": 19.62, + "Num Positive per mm^2": 1670.7 + } +} \ No newline at end of file diff --git a/170/TumorCenter_CD3_block17_x4_y1_patient170_1.json b/170/TumorCenter_CD3_block17_x4_y1_patient170_1.json new file mode 100644 index 0000000000000000000000000000000000000000..80f87060767080e14b1607fec56fa8bdeafe791d --- /dev/null +++ b/170/TumorCenter_CD3_block17_x4_y1_patient170_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 2498.7, + "Num Detections": 22217, + "Num Negative": 18230, + "Num Positive": 3987, + "Positive %": 17.95, + "Num Positive per mm^2": 1494.0 + } +} \ No newline at end of file diff --git a/170/TumorCenter_CD8_block17_x3_y1_patient170_0.json b/170/TumorCenter_CD8_block17_x3_y1_patient170_0.json new file mode 100644 index 0000000000000000000000000000000000000000..36cd697383fed7658ab16d7083a527c0be54ed13 --- /dev/null +++ b/170/TumorCenter_CD8_block17_x3_y1_patient170_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 16191.4, + "Num Detections": 25547, + "Num Negative": 25005, + "Num Positive": 542, + "Positive %": 2.122, + "Num Positive per mm^2": 212.71 + } +} \ No newline at end of file diff --git a/170/TumorCenter_CD8_block17_x4_y1_patient170_1.json b/170/TumorCenter_CD8_block17_x4_y1_patient170_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8eb78daa82aae0d7e19118d22393df0cf4438370 --- /dev/null +++ b/170/TumorCenter_CD8_block17_x4_y1_patient170_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 16016.5, + "Num Detections": 24612, + "Num Negative": 23927, + "Num Positive": 685, + "Positive %": 2.783, + "Num Positive per mm^2": 260.83 + } +} \ No newline at end of file diff --git a/170/history_text.txt b/170/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..75e80fb15283ae0bad94e6c6970832cc392da71e --- /dev/null +++ b/170/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically (G2) confirmed squamous cell carcinoma of the left glottis with transition into the anterior commissure and the right vocal fold anteriorly as well as the ventriculus laryngeus and the subglottis on the left side. The vocal process of the arytenoid cartilage appears to be infiltrated. However, the patient vehemently rejects a laryngectomy and radiochemotherapy. For this reason, there is an indication for renewed microlaryngoscopy and an attempt at partial resection according to Leroux-Robert. \ No newline at end of file diff --git a/170/icd_codes.txt b/170/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/170/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/170/ops_codes.txt b/170/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2bb72ab7f96d1fee92244373919c7c3b50f20888 --- /dev/null +++ b/170/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/170/patient_clinical_data.json b/170/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..01b3d49969b9fc4b7830170d6ebc6939e723e470 --- /dev/null +++ b/170/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/170/patient_pathological_data.json b/170/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..95f8f8b4a8f77293224494c49eb2702d05f54706 --- /dev/null +++ b/170/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "170", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/170/surgery_description.txt b/170/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5a79ad9d8028afa2b22512afed57bf924461290e --- /dev/null +++ b/170/surgery_description.txt @@ -0,0 +1 @@ +MLE (Microlaryngoscopy and Endoscopy), Attempted partial laryngeal resection (Leroux Robert) diff --git a/170/surgery_report.txt b/170/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7c63b8b2e11bcf3bf84fe8cf9da3a2db5403f67a --- /dev/null +++ b/170/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating theater and positioning the patient. Introductory consultation with the anesthesia department and performance of the team time-out. If the tooth status is poor, insert the mouthguard and insert the small irrigation tube. The tube is removed for this purpose. Inspection with 0° optics. Here you can see an exophytic mass affecting the entire left vocal fold and extending into the laryngeal ventricle and the subglottis. The anterior commissure is also infiltrated and the anterior 3 mm of the right vocal fold. With Cormack I, the patient can also be adjusted very well with the size C small bore tube. However, due to the infiltration of the anterior commissure, the mass is not laser resectable. Now demonstration of the findings to , who advises a partial resection of the larynx according to Leroux-Robert. For this reason, placement of the accesses and the permanent catheter from the anesthesia. Injection, sterile ablation and draping. Marking the landmarks. Skin incision in a zigzag shape and dissection through the subcutaneous fatty tissue. Exposure of the prelaryngeal musculature and separation from it in the linea alba. Exposure of the larynx from the thyroid incisura to the cricoid cartilage. Exposure of the larynx in the sense of a dissection of the periosteum. Now saw open the larynx paramedian on the right side and cut the ligamentum conicum at this point. Open the larynx and inspect it. The larynx is opened paramedianally on the right side in order to be able to resect the anterior commissure and the anterior part of the right vocal fold. No tumor is now macroscopically visible here. The larynx is stretched open and the tumor is followed to the left side. Here the tumor is successively removed with the pointed scissors and the 15 mm scalpel as well as bipolar coagulation at a distance of approx. 1 cm. Basally, the thyroid cartilage is completely exposed and freed from the periosteum with the Freer. This is done without any problems and can be pushed off easily. Now successive further dissection of the tumor under suture marking and taking of the marginal samples during the resection. The proc vocalis of the arytenoid cartilage is infiltrated in the posterior region. For this reason, add and . As the remaining part of the arytenoid cartilage can remain in place and swallowing should therefore be possible and a tracheostomy should be avoided, the vocal process is removed and the remaining arytenoid cartilage is left in place. Now take circular margin samples. Make 4 drill holes through the thyroid cartilage. Careful hemostasis and waiting for the frozen section. This was found to be tumor-free everywhere, with infiltrates only visible in the paraglottic space on the left side. This is resected again and circular margin samples are taken again. These are again sent for frozen section and are tumor-free. An R0 situation can therefore be assumed in the frozen section. It must be expressly mentioned here that the resection was performed with restraint at the express wish of the patient in order to protect the arytenoid cartilage and avoid a permanent tracheostomy. A further resection would have led to an opening of the pharynx and thus to a laryngectomy, which the patient also refused. In the current R0 situation, suture the right vocal fold anteriorly to improve vocal fold tension and successive hemostasis. Pharyngeal mucosa is visible on the left side, but is intact. Insertion of fibrin glue. Now suture the ligamentum conicum to the thyroid cartilage and insert a Keel. Closure of the prelaryngeal musculature as well as the subcutaneous fatty tissue and skin after insertion of a flap. Now insertion of a nasogastric tube and demonstration of the findings to the anesthesia colleagues. End of the operation. Conclusion: V.a. cT2 cN0 cM0 transglottic laryngeal carcinoma on the left side. Neck dissection on both sides was omitted due to the cN0 neck status after consultation with . The frozen section showed an R0 resection. The final histology should be awaited and the patient should be presented at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/171/InvasionFront_CD3_block22_x3_y12_patient171_0.json b/171/InvasionFront_CD3_block22_x3_y12_patient171_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7dd26a30e0ac6ccf1eeb9c864d95e1444e5233c2 --- /dev/null +++ b/171/InvasionFront_CD3_block22_x3_y12_patient171_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11518.9, + "Centroid Y µm": 41503.0, + "Num Detections": 26153, + "Num Negative": 23961, + "Num Positive": 2192, + "Positive %": 8.381, + "Num Positive per mm^2": 815.75 + } +} \ No newline at end of file diff --git a/171/InvasionFront_CD3_block22_x4_y12_patient171_1.json b/171/InvasionFront_CD3_block22_x4_y12_patient171_1.json new file mode 100644 index 0000000000000000000000000000000000000000..17d5d84e3041128d427f0483fd5ccdc79118d1da --- /dev/null +++ b/171/InvasionFront_CD3_block22_x4_y12_patient171_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14217.5, + "Centroid Y µm": 41702.9, + "Num Detections": 22742, + "Num Negative": 20688, + "Num Positive": 2054, + "Positive %": 9.032, + "Num Positive per mm^2": 818.74 + } +} \ No newline at end of file diff --git a/171/InvasionFront_CD8_block22_x3_y12_patient171_0.json b/171/InvasionFront_CD8_block22_x3_y12_patient171_0.json new file mode 100644 index 0000000000000000000000000000000000000000..003e745eceaf754fadcae28e8d45a22ffad3fa14 --- /dev/null +++ b/171/InvasionFront_CD8_block22_x3_y12_patient171_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14442.4, + "Centroid Y µm": 29234.5, + "Num Detections": 28027, + "Num Negative": 27699, + "Num Positive": 328, + "Positive %": 1.17, + "Num Positive per mm^2": 117.42 + } +} \ No newline at end of file diff --git a/171/InvasionFront_CD8_block22_x4_y12_patient171_1.json b/171/InvasionFront_CD8_block22_x4_y12_patient171_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a6634b992b080c573806bee7fe5f3e40bc51abd4 --- /dev/null +++ b/171/InvasionFront_CD8_block22_x4_y12_patient171_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 29309.5, + "Num Detections": 12779, + "Num Negative": 12639, + "Num Positive": 140, + "Positive %": 1.096, + "Num Positive per mm^2": 75.05 + } +} \ No newline at end of file diff --git a/171/TumorCenter_CD3_block22_x3_y12_patient171_0.json b/171/TumorCenter_CD3_block22_x3_y12_patient171_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90dcfc36bec0ffa2c3d58a5d5d8610963343e029 --- /dev/null +++ b/171/TumorCenter_CD3_block22_x3_y12_patient171_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 30134.0, + "Num Detections": 15382, + "Num Negative": 14119, + "Num Positive": 1263, + "Positive %": 8.211, + "Num Positive per mm^2": 608.74 + } +} \ No newline at end of file diff --git a/171/TumorCenter_CD3_block22_x4_y12_patient171_1.json b/171/TumorCenter_CD3_block22_x4_y12_patient171_1.json new file mode 100644 index 0000000000000000000000000000000000000000..99e4303337ff946dfd04db6fefdc71e8044ef0f6 --- /dev/null +++ b/171/TumorCenter_CD3_block22_x4_y12_patient171_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 30309.0, + "Num Detections": 25336, + "Num Negative": 22919, + "Num Positive": 2417, + "Positive %": 9.54, + "Num Positive per mm^2": 897.85 + } +} \ No newline at end of file diff --git a/171/TumorCenter_CD8_block22_x3_y12_patient171_0.json b/171/TumorCenter_CD8_block22_x3_y12_patient171_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2b2d24bac76c3703e2abf721b290416c2a881b6f --- /dev/null +++ b/171/TumorCenter_CD8_block22_x3_y12_patient171_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13018.1, + "Centroid Y µm": 40003.8, + "Num Detections": 20806, + "Num Negative": 20195, + "Num Positive": 611, + "Positive %": 2.937, + "Num Positive per mm^2": 269.5 + } +} \ No newline at end of file diff --git a/171/TumorCenter_CD8_block22_x4_y12_patient171_1.json b/171/TumorCenter_CD8_block22_x4_y12_patient171_1.json new file mode 100644 index 0000000000000000000000000000000000000000..28f4405323e1d22f83e6455bbb8a72d191a7ecfc --- /dev/null +++ b/171/TumorCenter_CD8_block22_x4_y12_patient171_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15591.7, + "Centroid Y µm": 40253.7, + "Num Detections": 25503, + "Num Negative": 24551, + "Num Positive": 952, + "Positive %": 3.733, + "Num Positive per mm^2": 362.8 + } +} \ No newline at end of file diff --git a/171/history_text.txt b/171/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d9d2d31e8c915e7b4c79c1ea950ae010edcd9a2 --- /dev/null +++ b/171/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed glottic carcinoma on the left. The tumor was found to be laser resectable at the pre-panendoscopy. Histologically squamous cell carcinoma. The above-mentioned operation was therefore indicated. \ No newline at end of file diff --git a/171/icd_codes.txt b/171/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cfaa369fd6797c7ad67aef40e2b8d19b19b68701 --- /dev/null +++ b/171/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Larynx[D38.0 ] Neubildung bösartig Kehlkopf sonstige[C32.8 L] \ No newline at end of file diff --git a/171/ops_codes.txt b/171/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ca180612c6d3e1a9c6835ef20dae3cbce21ef301 --- /dev/null +++ b/171/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion am Larynx[5-302.5 ] Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/171/patient_clinical_data.json b/171/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a965b8dee1326dfc2faa4b850e03c28d283b7df6 --- /dev/null +++ b/171/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 50, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/171/patient_pathological_data.json b/171/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2e856c1e23bb18fa789deb7e3a89e2d605bc62f9 --- /dev/null +++ b/171/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "171", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 4, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/171/surgery_description.txt b/171/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a0cbdc6a64cad57d9388aa287968718539b7ebbc --- /dev/null +++ b/171/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Tracheotomy diff --git a/171/surgery_report.txt b/171/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..76882f4a72d0c07e4b7cf161b0d8aa48d6fca778 --- /dev/null +++ b/171/surgery_report.txt @@ -0,0 +1 @@ +First positioning of the head, insertion of the mouthguard and insertion of the MLE tube size C and D alternately. The tumor, which is located in the area of the left vocal fold, is revealed. Compared to the previous assessment, the tumor is significantly larger and the growth is not only limited to the vocal fold, but also extends in the direction of the morgue sinus and is significantly more broad-based in the anterior commissure. The tumor is now resected with the laser at the back of the healthy area. Resection extends cranially to above the left pocket crease, resection is performed at the same height in the anterior commissure. Resection extends to the cartilage due to the significantly enlarged tumor growth. Adjustability of the anterior commissure, with relatively voluminous tumor, significantly more difficult. The tumor is therefore reduced in size and removed using the piecemeal technique. This significantly improves the overview. Resection extends slightly over the commissure to the right side at the very front. Detachment of the tumor. Dissection of the cartilage in the area of the anterior commissure. Destruction of the cartilage is evident here and tumor growth into the cartilage, therefore indication for an external procedure. The patient is repositioned and a total of 10 ml Ultracaine 1% with adrenaline is injected. A Z-shaped skin incision is then made prelaryngeally, ending in a Kocher collar incision. Dissection to the prelaryngeal muscle. This is split in the middle. A pZZZZcondral flap is dissected from the left over the anterior commissure. The cartilage is not infiltrated or even perforated on the outside. A median thyrotomy is created by cutting out a triangle or box-shaped piece of cartilage to the left. Cartilage is resected from the right paramedian to the left via the possible infiltration zone on the inside. Overview now improved. Mucosal remnants with tumor residues lying in front of the cartilage are also resected. Also soft tissue on the left caudal side in front of the cartilage. Co-resection of the ligamentum conicum. Marginal samples are taken in the area of the anterior commissure caudally from the area of the thyroid membrane, caudally on the left in the subglottic area, thread-marked in the arytenoid area, the soft tissue basally, supraglottically in the middle in the area of the anterior commissure, supraglottically on the left thread-marked as well as in the area of the right pouch ligament and vocal cord on the opposite side. All marginal samples go to the frozen section. Relatively little epithelium in the supraglottic center frozen section, but only slight dysplasia visible here. With a currently comprehensible R0 status, mucosa is again removed from the cranial area to be on the safe side, here already at the lower edge of the petiolus. However, this marginal sample is sent for final assessment. The removed cartilage and the fragmented tumor are also sent for final assessment. This is followed by careful hemostasis. The tracheostoma is created after the thyroid gland has been severed in the isthmus area. This is treated with stitches. Visualization of the trachea. Creation of a broadly pedicled Björk flap in the 2nd/3rd intermediate cartilage. Epithelialization of this. Subsequently, closure of the thyroid cartilage via drilled holes. The perichondrium flap is then placed over the thyrofissure and covers it completely. Fixation with 4-0 Vicryl single button sutures on the soft tissues caudally and on the perichondrium on the opposite side. Cranial suture of the soft tissues also with 4-0 Vicryl single button sutures with 4-0 Vicryl single button sutures. Then suture the infrahyoid musculature above with 3-0 Vicryl single button sutures. Then insertion of a flap. Layered skin closure in the typical manner. After lateral tracheotomy, an 8 mm tracheostomy tube was inserted. The procedure was completed without complications. Overall cT2 laryngeal carcinoma of the left vocal fold, growing into the anterior commissure. Therefore switch from transoral laser resection to frontolateral partial laryngectomy. Overall signs of a relatively fast-growing tumor. Microscopically R0 resection intraoperatively. Postoperative swallowing test, if problems persist insertion of a gastric tube and temporary feeding via this. Then presentation to the voice and speech department to initiate swallowing training as soon as possible. However, the swallowing function should not be impaired by the defect in the larynx area. Wait for the final marginal samples and discuss the further procedure at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/172/InvasionFront_CD3_block2_x3_y1_patient172_0.json b/172/InvasionFront_CD3_block2_x3_y1_patient172_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a583d290f702c284622ed3e33cb7380195cf6dca --- /dev/null +++ b/172/InvasionFront_CD3_block2_x3_y1_patient172_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 16091.5, + "Num Detections": 18578, + "Num Negative": 17800, + "Num Positive": 778, + "Positive %": 4.188, + "Num Positive per mm^2": 325.27 + } +} \ No newline at end of file diff --git a/172/InvasionFront_CD3_block2_x4_y1_patient172_1.json b/172/InvasionFront_CD3_block2_x4_y1_patient172_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f9309937575378e3c9b628887d8e1feaefc3e7a --- /dev/null +++ b/172/InvasionFront_CD3_block2_x4_y1_patient172_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 16216.4, + "Num Detections": 13273, + "Num Negative": 12927, + "Num Positive": 346, + "Positive %": 2.607, + "Num Positive per mm^2": 218.34 + } +} \ No newline at end of file diff --git a/172/InvasionFront_CD8_block2_x3_y1_patient172_0.json b/172/InvasionFront_CD8_block2_x3_y1_patient172_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4e1d3d5f83a8d0a63f159d9148c97e3a18bc64d5 --- /dev/null +++ b/172/InvasionFront_CD8_block2_x3_y1_patient172_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12543.4, + "Centroid Y µm": 3698.0, + "Num Detections": 18257, + "Num Negative": 17763, + "Num Positive": 494, + "Positive %": 2.706, + "Num Positive per mm^2": 225.39 + } +} \ No newline at end of file diff --git a/172/InvasionFront_CD8_block2_x4_y1_patient172_1.json b/172/InvasionFront_CD8_block2_x4_y1_patient172_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4927632a515ad4b4f68f9108ee29d3791bc359e7 --- /dev/null +++ b/172/InvasionFront_CD8_block2_x4_y1_patient172_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15117.0, + "Centroid Y µm": 3698.0, + "Num Detections": 15462, + "Num Negative": 15365, + "Num Positive": 97, + "Positive %": 0.6273, + "Num Positive per mm^2": 56.22 + } +} \ No newline at end of file diff --git a/172/TumorCenter_CD3_block2_x3_y1_patient172_0.json b/172/TumorCenter_CD3_block2_x3_y1_patient172_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fa497b04578ba353d1740a2fe41afe346b963f62 --- /dev/null +++ b/172/TumorCenter_CD3_block2_x3_y1_patient172_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 2398.7, + "Num Detections": 16099, + "Num Negative": 14540, + "Num Positive": 1559, + "Positive %": 9.684, + "Num Positive per mm^2": 735.22 + } +} \ No newline at end of file diff --git a/172/TumorCenter_CD3_block2_x4_y1_patient172_1.json b/172/TumorCenter_CD3_block2_x4_y1_patient172_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3318ccac236dc50da5b5e86bf231c30a87f4f770 --- /dev/null +++ b/172/TumorCenter_CD3_block2_x4_y1_patient172_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14442.4, + "Centroid Y µm": 2548.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/172/TumorCenter_CD8_block2_x3_y1_patient172_0.json b/172/TumorCenter_CD8_block2_x3_y1_patient172_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba8bb1925c251c0baacb9d2c4d1752e0f7d08047 --- /dev/null +++ b/172/TumorCenter_CD8_block2_x3_y1_patient172_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12843.2, + "Centroid Y µm": 2248.8, + "Num Detections": 17881, + "Num Negative": 17205, + "Num Positive": 676, + "Positive %": 3.781, + "Num Positive per mm^2": 294.48 + } +} \ No newline at end of file diff --git a/172/TumorCenter_CD8_block2_x4_y1_patient172_1.json b/172/TumorCenter_CD8_block2_x4_y1_patient172_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c016d559c0084e745315e78031f70304caf4d169 --- /dev/null +++ b/172/TumorCenter_CD8_block2_x4_y1_patient172_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15341.9, + "Centroid Y µm": 2073.9, + "Num Detections": 17613, + "Num Negative": 17247, + "Num Positive": 366, + "Positive %": 2.078, + "Num Positive per mm^2": 163.38 + } +} \ No newline at end of file diff --git a/172/history_text.txt b/172/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a940d8a472ff5b873fe3d4ae82d354cf51971c23 --- /dev/null +++ b/172/history_text.txt @@ -0,0 +1 @@ +The patient has had a pronounced oral floor of the tongue leukoplakia on the left side since 2012, which has already been removed several times. In addition, the patient has a history of papillary microcarcinoma of the thyroid gland on the right with complete thyroidectomy and central neck dissection in 2013 and has noticed a mass under the tongue since <2016>. Mirror findings revealed an exophytic mass on the anterior floor of the mouth on the left side in addition to several leukoplakic changes. There was also an exophytic mass in the piriform sinus on the left side, hence the indication for the above-mentioned procedure. In the tumor conference, the surgical procedure was concluded as the patient was not suitable for primary radiochemotherapy due to renal insufficiency. \ No newline at end of file diff --git a/172/icd_codes.txt b/172/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb89753ebfb3d0caa9c87e67aa5d7ff4cd45ec88 --- /dev/null +++ b/172/icd_codes.txt @@ -0,0 +1 @@ +Karzinom vorderer Mundboden[C04.0 ] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/172/ops_codes.txt b/172/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8b7fdb6e2285b252ec0a80a3dab5e87b56df98bd --- /dev/null +++ b/172/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Ösophagomyotomie sonstige[5-420.0x ] Permanente Tracheotomie[5-312.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Mundbodentumorexzision[5-273.3 ] Zungentumorexzision[5-250.2 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion Sonstige[5-295.1x ] Großflächige freie Spalthauttransplantation am Kopf[5-902.44 ] \ No newline at end of file diff --git a/172/patient_clinical_data.json b/172/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..963a73dbdb8a753ac5d2366b3c827ca31bdaf29d --- /dev/null +++ b/172/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/172/patient_pathological_data.json b/172/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..18817adcab11a91991e6da42d61dc3076e7a682a --- /dev/null +++ b/172/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "172", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/172/surgery_description.txt b/172/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..22d3554241281f37666f19222adcf69509c47d65 --- /dev/null +++ b/172/surgery_description.txt @@ -0,0 +1 @@ +Pharyngotomy, Laryngectomy, Neck dissection, PEG, Voice Prosthesis, Tracheotomy diff --git a/172/surgery_report.txt b/172/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a274c2756a637f9c6db415b7f07da86d579624ad --- /dev/null +++ b/172/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation transnasally via the anesthesia colleagues. Then first resection of the carcinoma of the floor of the mouth with the monopolar needle, bipolar forceps and scissors. The specimen is placed on cork, including edge samples for a frozen section. Carcinoma in situ is still visible in 2 places, on the lateral edge of the tongue at the transition to the floor of the mouth and in the middle on the underside of the tongue. On the underside of the tongue, a further 2 x resection is required until the edges of the carcinoma in itu are free. This results in an 8 x 5 cm defect in the floor of the mouth and the underside of the tongue. The ostium of the Wharton's duct on the left side is also covered by the tumor, as is the duct, so that no duct probing could be performed here and the duct and ostium as well as parts of the sublingual gland were resected. The remaining parts of the gland are coagulated in a bipolar fashion and later left open. The right ostium of the Wharton's duct is not affected by the tumor resection. Now turn to the neck. Creation of an apron flap in the usual manner, then parallel neck dissection on the right , on the left . Right: visualization of the sternocleidomastoid muscle, the omohyoid muscle and the submandibular gland, the cervical vascular sheath, hypoglossal nerve, accessorius nerve and vagus nerve. Free preparation of the internal jugular vein. Then removal of the neck preparations IIa to Va while sparing the plexus branches. Then release of the submandibular gland and evacuation of neck levels Ia and b. Several enlarged lymph nodes are seen in all levels, but none of them are macroscopically suspicious. Left: Visualization of the sternocleidomastoid muscle, the digastric muscle, the omohyoid muscle and the submandibular muscle. Exposure of the accessorius and hypoglossal nerves. Now exposure and dissection of the internal jugular vein. Clearing out the neck levels I-Va while sparing the plexus branches. Here too, several enlarged lymph nodes, but none of them macroscopically suspicious. Now turn to the larynx. The larynx is released on both sides. To do this, the hyoid bone is removed, releasing the infrahyoid muscles, which are beaten downwards. Then place the oblique laryngeal muscles and release the upper thyroid cartilage horn. Then release the piriform sinus and the thyroid cartilage on both sides. Be more careful on the left side due to possible tumor infiltration through the pharyngeal wall. Then enter with the Kleinsasser tube and inspect the localization of the tumour again. Then incision of the pharynx above the tumor 2 cm safety margin. Opening of the pharynx. This shows that there are 2 separate tumors. One on the lateral pharyngeal wall, which is 1.5 cm in size with a central ulcer, this ulcer runs through the entire pharyngeal wall. Then medially, a superficial tumor affecting the mucosa on the arytenoid cartilage and in the medial area of the piriform sinus. Both tumors are next to each other, but have healthy mucosa in between. However, they are so close together that both are resected in one block. Then marginal samples are taken and the specimen is sent to the pathology department on cork. All margin samples are R0 in the frozen section, without carcinoma in situ. Now perform the laryngectomy. Proceed from caudal to ventral. Deposition of the larynx at the cricoid cartilage, then dissection along the cricoid cartilage and the entire laryngeal skeleton in a cranial direction so that the larynx is completely released with maximum mucosal preservation. Removal of the vocal folds for the research laboratory and sending the laryngeal preparation for pathology. The base of the tongue was then released and the dorso-lateral left myotomy performed. Prior to this, a Provox Vega prosthesis was inserted in the usual manner. Then three-layer pharyngeal suture by , insertion of 2 Redon drains and return to the mouth. The defect on the underside of the tongue is covered with split skin. The split skin comes from the right thigh. Stitch incisions are made through the split skin and sutures are applied. At the end, a compress is sutured and the entire procedure is completed without complications. Please present the patient to the tumor conference to plan radiotherapy. The procedure was discussed intraoperatively at each stage with , , and . \ No newline at end of file diff --git a/173/InvasionFront_CD3_block21_x5_y12_patient173_0.json b/173/InvasionFront_CD3_block21_x5_y12_patient173_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d5a2dfaec2112f72b46f23a93d46fbaf30302a38 --- /dev/null +++ b/173/InvasionFront_CD3_block21_x5_y12_patient173_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17940.5, + "Centroid Y µm": 41003.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/173/InvasionFront_CD3_block21_x6_y12_patient173_1.json b/173/InvasionFront_CD3_block21_x6_y12_patient173_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d1500426f8fd48fcbf46f9b19b5e330b087d0c8 --- /dev/null +++ b/173/InvasionFront_CD3_block21_x6_y12_patient173_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20389.2, + "Centroid Y µm": 41153.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/173/InvasionFront_CD8_block21_x5_y12_patient173_0.json b/173/InvasionFront_CD8_block21_x5_y12_patient173_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a975a2156e9478c0a9282b0e636b5d20627a252 --- /dev/null +++ b/173/InvasionFront_CD8_block21_x5_y12_patient173_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 29234.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/173/InvasionFront_CD8_block21_x6_y12_patient173_1.json b/173/InvasionFront_CD8_block21_x6_y12_patient173_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd985c0600d498d05e8d5953d42162df8b3cbe12 --- /dev/null +++ b/173/InvasionFront_CD8_block21_x6_y12_patient173_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18765.1, + "Centroid Y µm": 29209.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/173/TumorCenter_CD8_block21_x5_y12_patient173_0.json b/173/TumorCenter_CD8_block21_x5_y12_patient173_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0caa0ef2fbfcd58327abe4a30a48c8b060a20af --- /dev/null +++ b/173/TumorCenter_CD8_block21_x5_y12_patient173_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17503.0, + "Centroid Y µm": 44602.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/173/TumorCenter_CD8_block21_x6_y12_patient173_1.json b/173/TumorCenter_CD8_block21_x6_y12_patient173_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2800e5f2f1c31bfb63312ddcbf96442cde2212db --- /dev/null +++ b/173/TumorCenter_CD8_block21_x6_y12_patient173_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19692.0, + "Centroid Y µm": 44511.7, + "Num Detections": 11597, + "Num Negative": 11320, + "Num Positive": 277, + "Positive %": 2.389, + "Num Positive per mm^2": 183.1 + } +} \ No newline at end of file diff --git a/173/history_text.txt b/173/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7373669e330be6ea0a306f661b3e393d59e2b272 --- /dev/null +++ b/173/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT1b laryngeal carcinoma clinically. CT showed no evidence of infiltration of the thyroid cartilage in the anterior commissure area. Therefore, the above-mentioned surgery was indicated. \ No newline at end of file diff --git a/173/icd_codes.txt b/173/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6fd121dc40d22b6fb46d31a947332bc01b0c9d --- /dev/null +++ b/173/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/173/ops_codes.txt b/173/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5700f143129d267b7baa80e51692e18f3f555f47 --- /dev/null +++ b/173/ops_codes.txt @@ -0,0 +1 @@ +Andere partielle Laryngektomie: Endoskopische Laserresektion[5-302.5 ] \ No newline at end of file diff --git a/173/patient_clinical_data.json b/173/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6cd372818b67b6443a649d09baadb63abd11f7d4 --- /dev/null +++ b/173/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 44, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/173/patient_pathological_data.json b/173/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..decdcc58271b15757066e9048b8267ee5d2db784 --- /dev/null +++ b/173/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "173", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/173/surgery_description.txt b/173/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0f6c5a09885fdd5e27824fdac12f633f0f4079c5 --- /dev/null +++ b/173/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of laryngeal carcinoma diff --git a/173/surgery_report.txt b/173/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..675f70ab2cfc1348d6858ecaa110ef640b7068bf --- /dev/null +++ b/173/surgery_report.txt @@ -0,0 +1 @@ +First of all, MLE once again: positioning of the tumor. This sits broadly in the area of the anterior vocal fold, sits broadly in the area of the anterior commissure, extends subglottically and extends almost to the middle of the vocal fold on the right, but here superficially. Tumor also extends anteriorly somewhat to the supraglottic and left anterior transition towards the ventriculus laryngis. However, the free mucosal margin is still clearly visible. The next step is laser resection with a 4 watt pulsed laser; the tumor is removed in several fractions. Complete resection of the left vocal fold up to the arytenoid cartilage is performed, including the subglottic slope up to the cricoid cartilage as well as the laryngeal ventricle and parts of the left pouch ligament at the front. The supraglottic area is also resected in the front. Resection extends to the right, here the anterior part of the vocal fold is resected according to the real superficial extent of the tumor. In the anterior area, extending to the right and left, the thyroid cartilage is exposed from the supraglottic area down to the cricoid cartilage. Cartilage areas macroscopically free. Removal of the soft tissue is possible without visible tumor contact. Marginal samples are now taken from the subglottic area, from the cricothyroid membrane area and from the anterior commissure area. A marginal sample is also taken from the entire surface of the right vocal cord. In addition, a left dorsal marginal sample from the arytenoid region, left caudal, left cranial and left basal. In the frozen section, except for the left dorsal margin sample, in which carcinomas are still detectable in situ, all margin samples are healthy. Therefore, the resection in the arytenoid region is now carried out again with the laser, including parts of the anterior arytenoid cartilage. In addition, a strip of mucosa from the entire posterior area is sent in again as a marginal sample for the frozen section. No more infiltrates detectable here. Thus R0 resection status. Careful hemostasis is performed with supratabs and monopolar. No bleeding at the final inspection. Completion of the procedure without complications. Overall extensive laser resection of a cT2 carcinoma. The thyroid cartilage and cricoid cartilage are exposed anteriorly and laterally, more on the left than on the right, as is the cricothyroid membrane. For this reason, the patient was given Sobelin intraoperatively. Antibiotics should be continued for about 1 week. Postoperatively, due to the extent of the tumor and after laser resection, control MLE is essential after 10 to 12 weeks. \ No newline at end of file diff --git a/174/InvasionFront_CD3_block21_x1_y9_patient174_0.json b/174/InvasionFront_CD3_block21_x1_y9_patient174_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3b26261e4d74e5aaffe0e2b5d829e1a2d0c15ab9 --- /dev/null +++ b/174/InvasionFront_CD3_block21_x1_y9_patient174_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5497.1, + "Centroid Y µm": 32682.7, + "Num Detections": 9445, + "Num Negative": 9018, + "Num Positive": 427, + "Positive %": 4.521, + "Num Positive per mm^2": 372.65 + } +} \ No newline at end of file diff --git a/174/InvasionFront_CD3_block21_x2_y9_patient174_1.json b/174/InvasionFront_CD3_block21_x2_y9_patient174_1.json new file mode 100644 index 0000000000000000000000000000000000000000..810fb7f0dafaa099cb052b64953aff239a557481 --- /dev/null +++ b/174/InvasionFront_CD3_block21_x2_y9_patient174_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8106.3, + "Centroid Y µm": 32812.2, + "Num Detections": 14211, + "Num Negative": 12746, + "Num Positive": 1465, + "Positive %": 10.31, + "Num Positive per mm^2": 896.86 + } +} \ No newline at end of file diff --git a/174/InvasionFront_CD8_block21_x1_y9_patient174_0.json b/174/InvasionFront_CD8_block21_x1_y9_patient174_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cb948f8914a662e25617082c9b9083b8914ae5db --- /dev/null +++ b/174/InvasionFront_CD8_block21_x1_y9_patient174_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 22138.3, + "Num Detections": 21005, + "Num Negative": 19837, + "Num Positive": 1168, + "Positive %": 5.561, + "Num Positive per mm^2": 488.13 + } +} \ No newline at end of file diff --git a/174/InvasionFront_CD8_block21_x2_y9_patient174_1.json b/174/InvasionFront_CD8_block21_x2_y9_patient174_1.json new file mode 100644 index 0000000000000000000000000000000000000000..207cea364ede98ed8d55c38fbcbb2e45aab8a645 --- /dev/null +++ b/174/InvasionFront_CD8_block21_x2_y9_patient174_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 22163.3, + "Num Detections": 19302, + "Num Negative": 18255, + "Num Positive": 1047, + "Positive %": 5.424, + "Num Positive per mm^2": 465.97 + } +} \ No newline at end of file diff --git a/174/TumorCenter_CD3_block21_x1_y9_patient174_0.json b/174/TumorCenter_CD3_block21_x1_y9_patient174_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac4efe18fb574f49b6ea8864f51e0117b1f63d55 --- /dev/null +++ b/174/TumorCenter_CD3_block21_x1_y9_patient174_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3746.4, + "Centroid Y µm": 25344.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/174/TumorCenter_CD3_block21_x2_y9_patient174_1.json b/174/TumorCenter_CD3_block21_x2_y9_patient174_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3f08959b8b002c735a5c6a67e12dedb4f5b9c244 --- /dev/null +++ b/174/TumorCenter_CD3_block21_x2_y9_patient174_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6345.0, + "Centroid Y µm": 25102.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/174/TumorCenter_CD8_block21_x1_y9_patient174_0.json b/174/TumorCenter_CD8_block21_x1_y9_patient174_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26b02498637b634af8da542c3b0e85934389ad99 --- /dev/null +++ b/174/TumorCenter_CD8_block21_x1_y9_patient174_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5572.0, + "Centroid Y µm": 37155.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/174/TumorCenter_CD8_block21_x2_y9_patient174_1.json b/174/TumorCenter_CD8_block21_x2_y9_patient174_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dbaee8c1df80a700caa3ff7cfac3f7d45c9734ed --- /dev/null +++ b/174/TumorCenter_CD8_block21_x2_y9_patient174_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8270.6, + "Centroid Y µm": 37180.3, + "Num Detections": 8811, + "Num Negative": 8791, + "Num Positive": 20, + "Positive %": 0.227, + "Num Positive per mm^2": 17.94 + } +} \ No newline at end of file diff --git a/174/history_text.txt b/174/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2e276706b964c68ada5289d29253de6b461b6da6 --- /dev/null +++ b/174/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: mass in the area of the larynx on the left side. \ No newline at end of file diff --git a/174/icd_codes.txt b/174/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d220406bb9f820a9488c92a1fdebe2fb59920ef7 --- /dev/null +++ b/174/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 ] \ No newline at end of file diff --git a/174/ops_codes.txt b/174/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..042f8acd58bf6db041e1a6782110d75732435a7e --- /dev/null +++ b/174/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie durch endoskopische Laserresektion[5-302.5 ] Diagnostische Laryngoskopie Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Diagnostische indirekte Pharyngoskopie[1-611.1 ] Diagnostische Laryngoskopie direkt[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument[1-620.1 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/174/patient_clinical_data.json b/174/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..82e7d6fcba2a11edc404870dcb2befeffc8a3898 --- /dev/null +++ b/174/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/174/patient_pathological_data.json b/174/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..366ca10788655d20cf72a0ef9db96ae5451bd095 --- /dev/null +++ b/174/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "174", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 2, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/174/surgery_description.txt b/174/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5462faa1f571443b90f96a41d612b40acfcafecc --- /dev/null +++ b/174/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection diff --git a/174/surgery_report.txt b/174/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..95828d96a915858f943881422df4522ffff0c0cd --- /dev/null +++ b/174/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthetist. Then advance the 0 degree optic through the glottic plane into the trachea. Further advancement into the bronchial system on both sides. No special features up to the exit of the segmental bronchi. No special features when reflecting back in the area of the trachea. Now intubation of the patient. First advance the flexible esophagoscope into the stomach. The mucosal conditions in the stomach and esophagus are normal. Now inspect the hypopharynx on both sides and the postcricoid region. Inconspicuous mucosal conditions here. No abnormalities in the oropharyngeal region either. Pulling up of the soft palate, no special features. No pathological mucosal changes in the nasopharyngeal region or in the oral cavity. Now adjustment of the larynx with the medium-sized small bore tube. In the region of the left larynx, starting from the left vocal cord, there is a mass that extends to just in front of the anterior commissure, into the morgue sinus and extends to the left pouch ligament. This mass extends dorsally to the posterior third of the vocal fold. Tissue is removed from this area and sent for frozen section examination. Histology revealed a squamous cell carcinoma. As discussed with the patient preoperatively, laser resection of this process is now performed. Adjustment with the medium-sized small water tube. The tumor can be well exposed. Now resect the tumor, resecting the vocal fold on the left side from the arytenoid cartilage to the anterior commissure and then resecting the pouch ligament and the morgue sinus upwards. The tip of the vocal process of the arytenoid cartilage and the thyroid cartilage are exposed. Bleeding is stopped with monopolar coagulation. As far as can be assessed intraoperatively, the resection is successful in sano. Several marginal samples are taken. Careful hemostasis. Difficult preparation conditions due to often somewhat difficult exposure. Now completion of the procedure. All examinations and manipulations with the aid of the endoscope or microscope. Final discussion with the anesthetist. A control MLE in approx. 6-8 weeks is absolutely necessary. Transfer of the patient to the recovery ward. Completion of the procedure. \ No newline at end of file diff --git a/175/InvasionFront_CD3_block16_x1_y11_patient175_0.json b/175/InvasionFront_CD3_block16_x1_y11_patient175_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7084f8ac360e19afa1b369ac759247378c7db5d7 --- /dev/null +++ b/175/InvasionFront_CD3_block16_x1_y11_patient175_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4515.7, + "Centroid Y µm": 31599.1, + "Num Detections": 8287, + "Num Negative": 8259, + "Num Positive": 28, + "Positive %": 0.3379, + "Num Positive per mm^2": 16.89 + } +} \ No newline at end of file diff --git a/175/InvasionFront_CD3_block16_x2_y11_patient175_1.json b/175/InvasionFront_CD3_block16_x2_y11_patient175_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c439aa6e7a30b3d65efca63229066476ff27339b --- /dev/null +++ b/175/InvasionFront_CD3_block16_x2_y11_patient175_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6865.3, + "Centroid Y µm": 31652.0, + "Num Detections": 9768, + "Num Negative": 9648, + "Num Positive": 120, + "Positive %": 1.229, + "Num Positive per mm^2": 61.11 + } +} \ No newline at end of file diff --git a/175/InvasionFront_CD8_block16_x1_y11_patient175_0.json b/175/InvasionFront_CD8_block16_x1_y11_patient175_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0c0829f2f75363a7619c675e0e1798497b5f82d5 --- /dev/null +++ b/175/InvasionFront_CD8_block16_x1_y11_patient175_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3312.3, + "Centroid Y µm": 26573.0, + "Num Detections": 6192, + "Num Negative": 6123, + "Num Positive": 69, + "Positive %": 1.114, + "Num Positive per mm^2": 92.33 + } +} \ No newline at end of file diff --git a/175/InvasionFront_CD8_block16_x2_y11_patient175_1.json b/175/InvasionFront_CD8_block16_x2_y11_patient175_1.json new file mode 100644 index 0000000000000000000000000000000000000000..51ea52db49d95234f71b7c399cc7ef426f6bd6d9 --- /dev/null +++ b/175/InvasionFront_CD8_block16_x2_y11_patient175_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5726.1, + "Centroid Y µm": 26532.6, + "Num Detections": 6883, + "Num Negative": 6752, + "Num Positive": 131, + "Positive %": 1.903, + "Num Positive per mm^2": 165.29 + } +} \ No newline at end of file diff --git a/175/TumorCenter_CD3_block16_x1_y12_patient175_0.json b/175/TumorCenter_CD3_block16_x1_y12_patient175_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7680975f982dd605d926852be64b09ce5ca0603 --- /dev/null +++ b/175/TumorCenter_CD3_block16_x1_y12_patient175_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3355.4, + "Centroid Y µm": 30050.0, + "Num Detections": 6893, + "Num Negative": 5718, + "Num Positive": 1175, + "Positive %": 17.05, + "Num Positive per mm^2": 1127.2 + } +} \ No newline at end of file diff --git a/175/TumorCenter_CD3_block16_x2_y12_patient175_1.json b/175/TumorCenter_CD3_block16_x2_y12_patient175_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ba0f0ea56d99518eade1cdefcf1a4c343f0f66c --- /dev/null +++ b/175/TumorCenter_CD3_block16_x2_y12_patient175_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5738.8, + "Centroid Y µm": 30056.0, + "Num Detections": 8354, + "Num Negative": 6461, + "Num Positive": 1893, + "Positive %": 22.66, + "Num Positive per mm^2": 865.77 + } +} \ No newline at end of file diff --git a/175/TumorCenter_CD8_block16_x1_y11_patient175_0.json b/175/TumorCenter_CD8_block16_x1_y11_patient175_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4701999c35407e8f3e2cd41f39a21f271745991f --- /dev/null +++ b/175/TumorCenter_CD8_block16_x1_y11_patient175_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3423.2, + "Centroid Y µm": 27610.4, + "Num Detections": 13674, + "Num Negative": 13031, + "Num Positive": 643, + "Positive %": 4.702, + "Num Positive per mm^2": 330.04 + } +} \ No newline at end of file diff --git a/175/TumorCenter_CD8_block16_x2_y11_patient175_1.json b/175/TumorCenter_CD8_block16_x2_y11_patient175_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4fe9d9842d97dc738c12ec3a22be765fffb3c90f --- /dev/null +++ b/175/TumorCenter_CD8_block16_x2_y11_patient175_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 27760.3, + "Num Detections": 14536, + "Num Negative": 14299, + "Num Positive": 237, + "Positive %": 1.63, + "Num Positive per mm^2": 120.11 + } +} \ No newline at end of file diff --git a/175/history_text.txt b/175/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff9b9ccb4698b0f4a15f93f2fec6c7ebcdcf7762 --- /dev/null +++ b/175/history_text.txt @@ -0,0 +1 @@ +Patient with externally confirmed cT3 exophytic growing tumor in the area of the right anterior tongue. \ No newline at end of file diff --git a/175/icd_codes.txt b/175/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bd499c58a417cfc54de3fb3d79d05e5befa06940 --- /dev/null +++ b/175/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 ] \ No newline at end of file diff --git a/175/ops_codes.txt b/175/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7b0dd103cffe17d6faca5e4a5923c6e603e3193c --- /dev/null +++ b/175/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x R] Diagnostische Pharyngoskopie direkt[1-611.0 ] Diagnostische Laryngotracheoskopie mit starrem Endoskop[1-620.1 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/175/patient_clinical_data.json b/175/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f5614d38505248b50df82eb8a8c5e4462ee47772 --- /dev/null +++ b/175/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 73, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/175/patient_pathological_data.json b/175/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..410e02df0f688a37258521f3a1c55947d70d2eb4 --- /dev/null +++ b/175/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "175", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/175/surgery_description.txt b/175/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..75c9bf7f758ab6a630ef73c278517ca376c365a3 --- /dev/null +++ b/175/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy diff --git a/175/surgery_report.txt b/175/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9822832c12d99e479ac831c19bceac9f7f2ab11 --- /dev/null +++ b/175/surgery_report.txt @@ -0,0 +1 @@ +First photo documentation, then prior to intubation adjustment of the laryngeal entrance with the laryngoscope and performance of tracheoscopy with the 0 degree scope: The trachea is unremarkable, as are the bifurcation and the visible main bronchi. After intubation, flexible esophagoscopy: The entire esophagus and stomach are unremarkable. Hypopharyngo- and laryngoscopy: Postcricoid region, esophageal entrance, pharyngeal side walls, posterior pharyngeal wall, vocal folds, supraglottic region, vallecula, tongue base and tonsil region unremarkable. Now insertion of a blocker into the oral cavity and suturing of a traction suture. An exophytic growing tumor can be seen in the area of the right half of the tongue, this infiltrates the tongue, but the largest part is exophytic growing, larger than 4 cm. The external histology revealed squamous cell carcinoma, which is why the tumor was immediately removed by partial excision of the tongue. This involves making an incision in the anterior part of the healthy muscle part of the tongue at a sufficient distance from the tumor. The entire tumor area is cut around with the electric knife down to the floor of the mouth and extirpated in toto. Sending the material for frozen section diagnostics. All edges are found to be tumor-free. The wound surface is bipolarly coagulated in some places. The artery or branches of the lingual artery were stitched several times intraoperatively. No bleeding at the end of the operation, no other special features. Waiting for the definitive histology and then discussion of the further procedure depending on the histology and neck status. \ No newline at end of file diff --git a/176/InvasionFront_CD3_block1_x3_y7_patient176_0.json b/176/InvasionFront_CD3_block1_x3_y7_patient176_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02db2a3c7e32e4b0df86ac0019eff476f5ce3a30 --- /dev/null +++ b/176/InvasionFront_CD3_block1_x3_y7_patient176_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 19264.8, + "Num Detections": 12657, + "Num Negative": 12319, + "Num Positive": 338, + "Positive %": 2.67, + "Num Positive per mm^2": 216.64 + } +} \ No newline at end of file diff --git a/176/InvasionFront_CD3_block1_x4_y7_patient176_1.json b/176/InvasionFront_CD3_block1_x4_y7_patient176_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aed3f7fabbcc67b5d0aa3e39e57621951a90082e --- /dev/null +++ b/176/InvasionFront_CD3_block1_x4_y7_patient176_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13992.6, + "Centroid Y µm": 19439.7, + "Num Detections": 15610, + "Num Negative": 14673, + "Num Positive": 937, + "Positive %": 6.003, + "Num Positive per mm^2": 505.22 + } +} \ No newline at end of file diff --git a/176/InvasionFront_CD8_block1_x3_y7_patient176_0.json b/176/InvasionFront_CD8_block1_x3_y7_patient176_0.json new file mode 100644 index 0000000000000000000000000000000000000000..74ac00c9ea42b4ad9c9e935c8d24e7373117223a --- /dev/null +++ b/176/InvasionFront_CD8_block1_x3_y7_patient176_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 17865.5, + "Num Detections": 14634, + "Num Negative": 14538, + "Num Positive": 96, + "Positive %": 0.656, + "Num Positive per mm^2": 57.83 + } +} \ No newline at end of file diff --git a/176/InvasionFront_CD8_block1_x4_y7_patient176_1.json b/176/InvasionFront_CD8_block1_x4_y7_patient176_1.json new file mode 100644 index 0000000000000000000000000000000000000000..56c8e8f4ea95ade60308b4643813640213499457 --- /dev/null +++ b/176/InvasionFront_CD8_block1_x4_y7_patient176_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14017.6, + "Centroid Y µm": 18015.5, + "Num Detections": 16260, + "Num Negative": 15959, + "Num Positive": 301, + "Positive %": 1.851, + "Num Positive per mm^2": 155.14 + } +} \ No newline at end of file diff --git a/176/TumorCenter_CD3_block1_x3_y9_patient176_0.json b/176/TumorCenter_CD3_block1_x3_y9_patient176_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8a6ea6524199b08b3a0889564dbf580c363fb342 --- /dev/null +++ b/176/TumorCenter_CD3_block1_x3_y9_patient176_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11100.1, + "Centroid Y µm": 22397.7, + "Num Detections": 17030, + "Num Negative": 16989, + "Num Positive": 41, + "Positive %": 0.2408, + "Num Positive per mm^2": 20.42 + } +} \ No newline at end of file diff --git a/176/TumorCenter_CD3_block1_x4_y9_patient176_1.json b/176/TumorCenter_CD3_block1_x4_y9_patient176_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f39f093ec88a55772f83444a5b2c6cfb853de145 --- /dev/null +++ b/176/TumorCenter_CD3_block1_x4_y9_patient176_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13466.0, + "Centroid Y µm": 22184.2, + "Num Detections": 17535, + "Num Negative": 17455, + "Num Positive": 80, + "Positive %": 0.4562, + "Num Positive per mm^2": 38.97 + } +} \ No newline at end of file diff --git a/176/TumorCenter_CD8_block1_x3_y7_patient176_0.json b/176/TumorCenter_CD8_block1_x3_y7_patient176_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7e2de876f6f181d11a37ec16518717ccb5decc50 --- /dev/null +++ b/176/TumorCenter_CD8_block1_x3_y7_patient176_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 26211.1, + "Num Detections": 7552, + "Num Negative": 7518, + "Num Positive": 34, + "Positive %": 0.4502, + "Num Positive per mm^2": 37.7 + } +} \ No newline at end of file diff --git a/176/TumorCenter_CD8_block1_x4_y7_patient176_1.json b/176/TumorCenter_CD8_block1_x4_y7_patient176_1.json new file mode 100644 index 0000000000000000000000000000000000000000..163fc2923a8fdf02052e485469b8ea25814c7bd6 --- /dev/null +++ b/176/TumorCenter_CD8_block1_x4_y7_patient176_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 26311.1, + "Num Detections": 18034, + "Num Negative": 17984, + "Num Positive": 50, + "Positive %": 0.2773, + "Num Positive per mm^2": 22.02 + } +} \ No newline at end of file diff --git a/176/history_text.txt b/176/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7058c6f2c81da88d597576905e38c21b15152f48 --- /dev/null +++ b/176/history_text.txt @@ -0,0 +1 @@ +The patient has a postoperative pT2 pN0 cM0 oropharyngeal carcinoma (ED 2009) with postoperative laser resection, neck dissection on both sides and adjuvant radiochemotherapy for residual carcinoma on the posterior pharyngeal wall with 72 Gy. In the tumor follow-up, CT imaging reveals a flat contrast agent image on the left edge of the tongue. The patient suffers from postradiogenic esophageal stenosis and laryngeal stenosis and is permanently tracheostomized. Based on the findings, the above-mentioned operation is indicated. Preoperatively, a sample was taken from the suspected tumor area on the left edge of the tongue. This revealed a squamous cell carcinoma. \ No newline at end of file diff --git a/176/icd_codes.txt b/176/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c48fe4f08c56983979ca33ab35ad42ee315c178 --- /dev/null +++ b/176/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] Funktionsstörung des Tracheostomas[J95.0 ] \ No newline at end of file diff --git a/176/ops_codes.txt b/176/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f90aa907658baad29aed2e67ea9b2975db9c8708 --- /dev/null +++ b/176/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Ösophagoskopie[1-630.x ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Biopsie durch Inzision anderer Organe am Hals[1-583 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/176/patient_clinical_data.json b/176/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1dc2b0a86d7d7e88f729e20009edeb9ca60d4a29 --- /dev/null +++ b/176/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + pembrolizumab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/176/patient_pathological_data.json b/176/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3ed055bdca4975c79f2b93ee89a34d2fd5cfd537 --- /dev/null +++ b/176/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "176", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/176/surgery_description.txt b/176/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3784007e8dc80110b808e9481882afe54011cb77 --- /dev/null +++ b/176/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of oropharyngeal wall carcinoma, Bilateral neck dissection, Tracheotomy diff --git a/176/surgery_report.txt b/176/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0e49b31fc74601848d8045683f2ec417bdd8aa01 --- /dev/null +++ b/176/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating theater. Carrying out the team time-out with the anesthesia colleagues and induction of intubation anesthesia by the colleagues. Induction of anesthesia through the existing tracheostoma. Now attempt panendoscopy. The patient is extremely difficult to view with the small bore tube due to the severe postradiogenic changes. No abnormalities in the hypopharynx and supraglottic larynx as far as can be assessed. The glottis cannot be adequately assessed, nor can the esophageal opening. A flexible gastroesophagoscopy is not performed as the mucosa is very vulnerable to contact and the lumen is very narrow. Closer inspection with the small flexible scope reveals an almost obliterated esophageal lumen. The placement of a nasogastric tube is also frustrating after several attempts. The tumor is now resected at the edge of the tongue on the left side with a safety margin of approx. 1 cm. Removal of the specimen under constant blood control using bipolar coagulation forceps and palpatory control. Now mark the suture and send the specimen for frozen section examination. After receipt of the frozen section findings, it is found that there is still carcinoma forming the margin in the specimen in the area of the posterior and medial margin (up to the central specimen). The decision is now made to perform a resection. The resection is performed from posterior to mid-medial and the specimen is again sent in thread-marked for histological frozen section examination. The 2nd frozen section is now reliably tumor-free. In summary, an R0 resection can therefore be assumed. Subtle hemostasis using bipolar coagulation forceps and completion of the procedure without complications. Finally, inspection of the fistula at the upper lateral edge of the tracheostoma on the left side. This shows a fistula channel approx. 2-3 mm wide, which is sharpened with the curette after obtaining a sample biopsy and a granulation-promoting dressing material is inserted. Please await the final histopathological assessment and case presentation in our tumor conference. \ No newline at end of file diff --git a/177/InvasionFront_CD3_block22_x1_y7_patient177_0.json b/177/InvasionFront_CD3_block22_x1_y7_patient177_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2e31b7f771f3469e45d65f91d97bc2adfa9d0008 --- /dev/null +++ b/177/InvasionFront_CD3_block22_x1_y7_patient177_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4722.5, + "Centroid Y µm": 28734.8, + "Num Detections": 19453, + "Num Negative": 17172, + "Num Positive": 2281, + "Positive %": 11.73, + "Num Positive per mm^2": 988.9 + } +} \ No newline at end of file diff --git a/177/InvasionFront_CD3_block22_x2_y7_patient177_1.json b/177/InvasionFront_CD3_block22_x2_y7_patient177_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a71efe36f5a302f79312a6b4ee45f9d2f94fbe25 --- /dev/null +++ b/177/InvasionFront_CD3_block22_x2_y7_patient177_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 28834.7, + "Num Detections": 20685, + "Num Negative": 18004, + "Num Positive": 2681, + "Positive %": 12.96, + "Num Positive per mm^2": 1178.0 + } +} \ No newline at end of file diff --git a/177/InvasionFront_CD8_block22_x1_y7_patient177_0.json b/177/InvasionFront_CD8_block22_x1_y7_patient177_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e1f6763818f2c71f1408aa4acb17ea5f502b2c07 --- /dev/null +++ b/177/InvasionFront_CD8_block22_x1_y7_patient177_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7337.7, + "Centroid Y µm": 17572.4, + "Num Detections": 17511, + "Num Negative": 15147, + "Num Positive": 2364, + "Positive %": 13.5, + "Num Positive per mm^2": 1075.8 + } +} \ No newline at end of file diff --git a/177/InvasionFront_CD8_block22_x2_y7_patient177_1.json b/177/InvasionFront_CD8_block22_x2_y7_patient177_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cda7922c235afc71abcbe4d535fb8ecd32944d46 --- /dev/null +++ b/177/InvasionFront_CD8_block22_x2_y7_patient177_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9564.4, + "Centroid Y µm": 17449.1, + "Num Detections": 19980, + "Num Negative": 17819, + "Num Positive": 2161, + "Positive %": 10.82, + "Num Positive per mm^2": 996.94 + } +} \ No newline at end of file diff --git a/177/TumorCenter_CD3_block22_x1_y7_patient177_0.json b/177/TumorCenter_CD3_block22_x1_y7_patient177_0.json new file mode 100644 index 0000000000000000000000000000000000000000..119f5b3bf287f12a24489eaf7749ff33b53497d0 --- /dev/null +++ b/177/TumorCenter_CD3_block22_x1_y7_patient177_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4422.7, + "Centroid Y µm": 17740.6, + "Num Detections": 16998, + "Num Negative": 16578, + "Num Positive": 420, + "Positive %": 2.471, + "Num Positive per mm^2": 215.99 + } +} \ No newline at end of file diff --git a/177/TumorCenter_CD3_block22_x2_y7_patient177_1.json b/177/TumorCenter_CD3_block22_x2_y7_patient177_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2233af7369a8b64af2c4a675e828457b3a4dfc55 --- /dev/null +++ b/177/TumorCenter_CD3_block22_x2_y7_patient177_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 17915.5, + "Num Detections": 11767, + "Num Negative": 10535, + "Num Positive": 1232, + "Positive %": 10.47, + "Num Positive per mm^2": 833.7 + } +} \ No newline at end of file diff --git a/177/TumorCenter_CD8_block22_x1_y7_patient177_0.json b/177/TumorCenter_CD8_block22_x1_y7_patient177_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04126b5148f9ad976c7f65e7d04952e1ef7df2ff --- /dev/null +++ b/177/TumorCenter_CD8_block22_x1_y7_patient177_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 27210.6, + "Num Detections": 12449, + "Num Negative": 11356, + "Num Positive": 1093, + "Positive %": 8.78, + "Num Positive per mm^2": 657.2 + } +} \ No newline at end of file diff --git a/177/TumorCenter_CD8_block22_x2_y7_patient177_1.json b/177/TumorCenter_CD8_block22_x2_y7_patient177_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3406fda7d4978b531328c7cb85701078cb5ef22 --- /dev/null +++ b/177/TumorCenter_CD8_block22_x2_y7_patient177_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8845.3, + "Centroid Y µm": 27335.5, + "Num Detections": 11901, + "Num Negative": 9343, + "Num Positive": 2558, + "Positive %": 21.49, + "Num Positive per mm^2": 1557.4 + } +} \ No newline at end of file diff --git a/177/history_text.txt b/177/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/177/icd_codes.txt b/177/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb59acd3eae4aa874f75298df3d5731de71d88e6 --- /dev/null +++ b/177/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/177/ops_codes.txt b/177/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..13c4d4be65a59d1c8c5b4c0c1d6e5ef9b60992e5 --- /dev/null +++ b/177/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 4 Regionen[5-403.10 L] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/177/patient_clinical_data.json b/177/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9a8f6d80fab9699c8c70a2ee9d6e9f9e50d8c31b --- /dev/null +++ b/177/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 58, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/177/patient_pathological_data.json b/177/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b8979aab08ce1df3d97ae4779f1c53d29c4f2ee0 --- /dev/null +++ b/177/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "177", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 67, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/177/surgery_description.txt b/177/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0b7a149d7a04f0966bf049f5277fdd7cf6a1fb7 --- /dev/null +++ b/177/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, Tracheotomy diff --git a/177/surgery_report.txt b/177/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ca6f2283e55fba85741fc33ec191474e4976b94 --- /dev/null +++ b/177/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater and positioning of the patient. Introductory consultation with the anesthesia department. Carrying out the team time-out. Start of panendoscopy to determine the extent of the tumor again. Insertion of a nasogastric tube. Injection of suprarenin with lidocaine, sterile abjodation and draping. Start with the apron flap. If there is a large metastasis on the left side and a pharyngostoma may be present, the incision on the left side is not made symmetrically but slightly anteriorly. Dissection through the subcutaneous fatty tissue and dissection of the apron flap. Expose the submandibular gland on both sides. Now start with the neck dissection on the left side. Dissection of the omohyoid muscle. A soft tissue metastasis is revealed, which can also be histologically confirmed by frozen section. Careful dissection of the anterior margin of the sternocleidomastoid muscle and the omohyoid muscle. Locate the internal jugular vein and follow it. Dissection in level IV. As the vein runs through the large lymph node metastasis, the decision is made to ligate or puncture the vein caudally. This is done without any problems. Now successive further dissection of the metastasis bundle from the sternocleidomastoid. This is done sharply and parts of the muscle are removed. Exposure of the accessorius nerve. This can be preserved and is followed cranially. Sharp dissection of the metastatic bundle of the accessory and common carotid arteries and of the bifurcation. This is successful without any problems and both structures can be preserved. The metastatic bundle can be removed. Removal of the medial and lateral neck preparation. The vagus nerve as well as the hypoglossal nerve can be spared without any problems. Dissection of the lateral neck preparation on the left side reveals cerebrospinal fluid flow in the form of a chyle fistula. However, this stops after suturing. Transition to the right side. Here too, expose the anterior border of the sternocleidomastoid muscle and dissect caudally. Trace the omohyoid muscle to the digastric muscle. Exposure of the submandibularis in its entirety on the right side and exposure of the digaster muscle and dissection of the internal jugular vein. The internal jugular vein and all its branches can be preserved. The common carotid artery and the vagus nerve can also be spared. Suspicious lymph nodes are also found in regions Ib and II. These are successively dissected. Exposure of the accessory nerve and preservation of the same. Successive removal of the lateral neck preparation while sparing the plexus branches. Dissection of the medial neck preparation and preservation of the hypoglossal nerve. As on the left side, there is no evidence of increased bleeding. L Proceed to laryngectomy. Free preparation of the larynx medial to the cervical vascular sheath on both sides. Dissection of the prelaryngeal musculature and folding it down. Dissecting the cornu majus of the thyroid cartilage and exposing it. Incision with the scalpel and removal of the mucosa from the thyroid cartilage with the Freer. An attempt is made to preserve as much mucosa as possible on the piriform sinus on the right side. Enter enorally with the TE retractor and transcervically into the pharyngeal tube. Expose the epiglottis and pull up the epiglottis with the triangular clamp. Successive dissection of the pharynx and larynx in order to be able to remove the entire tumor. This extends further cranially than expected. This is successful without any problems. Removal of the trachea in the usual manner. Assessment of the remaining pharyngeal tube. The decision is made to perform a primary closure. Removal of marginal samples and hemostasis. Closure of the pharynx in the usual T-shape. Successive placement of the mucosal sutures after releasing the pharyngeal tube from the base of the tongue to enable tension-free suturing. Multi-layer closure of the pharynx. Stitching over the pharyngeal tube with the dissected prelaryngeal musculature. Suturing in TachoSil. There is now no evidence of increased bleeding, chyle flow or salivation. For this reason, two Redon drains are inserted, one on each side, and the neck is closed in two layers. Sewing in the tracheostoma. Application of a pressure bandage, which should press on the suture site, especially submentally. Antibiotic treatment with 3 g Unacid. After a final consultation with the anesthetist, the operation is completed. Antibiotics should be continued for at least one week. If the pharyngeal tube is thin, Provox has not been used. A P&P presentation should be made at intervals. Presentation of the patient at the tumor conference after receipt of the histology. \ No newline at end of file diff --git a/178/InvasionFront_CD3_block17_x3_y3_patient178_0.json b/178/InvasionFront_CD3_block17_x3_y3_patient178_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fc430076ec446aebb8044637990a388cc421eb3c --- /dev/null +++ b/178/InvasionFront_CD3_block17_x3_y3_patient178_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 12568.3, + "Num Detections": 22157, + "Num Negative": 21935, + "Num Positive": 222, + "Positive %": 1.002, + "Num Positive per mm^2": 93.2 + } +} \ No newline at end of file diff --git a/178/InvasionFront_CD3_block17_x4_y3_patient178_1.json b/178/InvasionFront_CD3_block17_x4_y3_patient178_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f1cef1699467f73ffb7e2a94595aa958d23832d9 --- /dev/null +++ b/178/InvasionFront_CD3_block17_x4_y3_patient178_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 12593.3, + "Num Detections": 18835, + "Num Negative": 18699, + "Num Positive": 136, + "Positive %": 0.7221, + "Num Positive per mm^2": 59.34 + } +} \ No newline at end of file diff --git a/178/InvasionFront_CD8_block17_x3_y3_patient178_0.json b/178/InvasionFront_CD8_block17_x3_y3_patient178_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be1c12357458b335eb9e8cbe4edfc0a5d2765561 --- /dev/null +++ b/178/InvasionFront_CD8_block17_x3_y3_patient178_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11219.1, + "Centroid Y µm": 7833.4, + "Num Detections": 20421, + "Num Negative": 20374, + "Num Positive": 47, + "Positive %": 0.2302, + "Num Positive per mm^2": 19.89 + } +} \ No newline at end of file diff --git a/178/InvasionFront_CD8_block17_x4_y3_patient178_1.json b/178/InvasionFront_CD8_block17_x4_y3_patient178_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1e664c70677e8afdb73b74d713f157b7c645f5eb --- /dev/null +++ b/178/InvasionFront_CD8_block17_x4_y3_patient178_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 7820.9, + "Num Detections": 19118, + "Num Negative": 18985, + "Num Positive": 133, + "Positive %": 0.6957, + "Num Positive per mm^2": 57.27 + } +} \ No newline at end of file diff --git a/178/TumorCenter_CD3_block17_x3_y3_patient178_0.json b/178/TumorCenter_CD3_block17_x3_y3_patient178_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42c3cb3a109ec03e506f0d3cf6ac1227c212091c --- /dev/null +++ b/178/TumorCenter_CD3_block17_x3_y3_patient178_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 7446.1, + "Num Detections": 20297, + "Num Negative": 17200, + "Num Positive": 3097, + "Positive %": 15.26, + "Num Positive per mm^2": 1200.0 + } +} \ No newline at end of file diff --git a/178/TumorCenter_CD3_block17_x4_y3_patient178_1.json b/178/TumorCenter_CD3_block17_x4_y3_patient178_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fa73ebdd8ff98ef0715e05a53c9489c498baaf3f --- /dev/null +++ b/178/TumorCenter_CD3_block17_x4_y3_patient178_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13467.9, + "Centroid Y µm": 7446.1, + "Num Detections": 21634, + "Num Negative": 18897, + "Num Positive": 2737, + "Positive %": 12.65, + "Num Positive per mm^2": 1067.8 + } +} \ No newline at end of file diff --git a/178/TumorCenter_CD8_block17_x3_y3_patient178_0.json b/178/TumorCenter_CD8_block17_x3_y3_patient178_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef451c881cebdb08d2d3c287339bb11fbd3a346d --- /dev/null +++ b/178/TumorCenter_CD8_block17_x3_y3_patient178_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 21113.8, + "Num Detections": 23172, + "Num Negative": 22874, + "Num Positive": 298, + "Positive %": 1.286, + "Num Positive per mm^2": 117.04 + } +} \ No newline at end of file diff --git a/178/TumorCenter_CD8_block17_x4_y3_patient178_1.json b/178/TumorCenter_CD8_block17_x4_y3_patient178_1.json new file mode 100644 index 0000000000000000000000000000000000000000..896044ed7fb396ee50b1a25ae53e57feb4a00c5e --- /dev/null +++ b/178/TumorCenter_CD8_block17_x4_y3_patient178_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16291.4, + "Centroid Y µm": 21038.9, + "Num Detections": 23787, + "Num Negative": 23562, + "Num Positive": 225, + "Positive %": 0.9459, + "Num Positive per mm^2": 86.2 + } +} \ No newline at end of file diff --git a/178/history_text.txt b/178/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..bba08c7e4ba1935e992f35a83f712b3ff1eae456 --- /dev/null +++ b/178/history_text.txt @@ -0,0 +1 @@ +In Mr. , a carcinoma in situ with focal transition to a G2-differentiated squamous cell carcinoma in the area of the right vocal fold was histologically confirmed in advance. Due to the poor adjustability, there is now an indication for partial laryngeal resection from the outside. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/178/icd_codes.txt b/178/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b6f71cefce893af31fb2e9010361238fc037c164 --- /dev/null +++ b/178/icd_codes.txt @@ -0,0 +1 @@ +Stimmlippenkarzinom[C32.0 R] \ No newline at end of file diff --git a/178/ops_codes.txt b/178/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..017c89a7f27981f7bae8a5476331b328964ea621 --- /dev/null +++ b/178/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/178/patient_clinical_data.json b/178/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c7e96c75bf254dace56ec14698060a02c2d68119 --- /dev/null +++ b/178/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 8, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/178/patient_pathological_data.json b/178/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1626f3aa79b5a872ce657efc56441d435bed0172 --- /dev/null +++ b/178/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "178", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris1", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/178/surgery_description.txt b/178/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..21df6e40bd9314a042ac73ad082c7fcd6c5fd5d2 --- /dev/null +++ b/178/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection from the outside diff --git a/178/surgery_report.txt b/178/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c1649b69319b3b75eb3b8087bb2c7284c8048875 --- /dev/null +++ b/178/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with anesthesia colleagues. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. Initial re-inspection of the endolarynx. Insertion of the mouth guard. Insertion of the size D small bore tube. With difficulty, the posterior commissure can be adjusted with the small bore tube. The anterior commissure can only be seen with the aid of the fixed telescope. There is a flat change in the right vocal fold, as already described in the previous panendoscopy. Removal of the small water tube and repositioning of the patient in head reclination. Skin spray disinfection and infiltration anesthesia in the area of the planned incision. Skin wipe disinfection and sterile draping. First mark the planned incision from the incisura thyroidea to the cricothyroid ligament. Make the incision using the broken-line technique. Sharp cutting of the cutis and subcutis. Dissection of the platysma and exposure of the prelaryngeal musculature. Locating the linea alba. Blunt lateralization of the prelaryngeal musculature. Insertion of the retractors. Clear identification of the incisura thyroidea and the ligamentum conicum as well as the level of the cricoid cartilage. Incision of the perichondrium and formation of 2 perichondrium flaps. These are beaten laterally. The laryngeal skeleton is then opened using the wheel. A horizontal incision is also made in the area of the ligamentum conicum. Open the larynx in the median line. You now have a very good overview of the vocal fold on the right side, which has changed over a large area. The extent of the resection is determined with the aid of 0° optics. Endoscopically, the suspicious mucosal change extends into the subglottic slope of the right side. Cranially, the abnormal mucosa extends into the morgue sinus. Maintaining an appropriate safety distance, the entire right vocal fold is now excised, including the vocal ligament and the vocalis muscle. Dorsally, the tumor is deposited on the vocal process of the arytenoid cartilage. Suture marking of the main preparation. Removal of marginal samples (right cranial vocal fold, right caudal vocal fold, anterior commissure, margin of the vocal process). Hemostasis using bipolar coagulation. During the intraoperative frozen section diagnosis, both the specimen and the margin samples show that clear extensions of a carcinoma in situ are still present on all sides. For this reason, circular resection was initially carried out and new marginal samples were taken. It is now also apparent that there are also clear CIS extensions in the area of the vocal fold on the left front. Therefore, the extent of the resection is extended over the anterior third of the vocal fold on the left to the middle third of the vocal fold up to just before the posterior third of the vocal fold. In the area of the right vocal fold, the entire subglottic slope is resected. The medial mucosa-covered surface is also resected in the area of the right arytenoid. Finally, there are still CIS extensions in the area of the left vocal fold and the right medial arytenoid surface. After further resection, new marginal samples are taken and sent for definitive histological examination. The extent of resection on the right ary extends here to just before the interarytenoid region. A further resection in the same session does not appear to make sense, also in view of the patient's numerous previous illnesses. Therefore, hemostasis using bipolar coagulation. Insertion of a 12 mm laryngeal wedge. Prior to this, 4 drill holes were made in the area of the thyroid cartilage. Fixation of the Keel with PDS 4.0, followed by folding back the perichondrium leaves and suturing them over the Keel. Suture the incision in the area of the ligamentum conicum. Mobilization of the lateralized muscle bellies with the prelaryngeal musculature and readaptation in the midline area. Insertion of a sterile flap. Subcutaneous suture with Vicryl 4.0 and skin suture with Ethilon 5.0. Final consultation with the anesthesia colleagues and completion of the operation without complications. \ No newline at end of file diff --git a/179/InvasionFront_CD3_block15_x3_y3_patient179_0.json b/179/InvasionFront_CD3_block15_x3_y3_patient179_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1e7740c639a42c97b1cfac9e33bdd47666a73c04 --- /dev/null +++ b/179/InvasionFront_CD3_block15_x3_y3_patient179_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12768.2, + "Centroid Y µm": 17540.7, + "Num Detections": 19561, + "Num Negative": 17934, + "Num Positive": 1627, + "Positive %": 8.318, + "Num Positive per mm^2": 633.98 + } +} \ No newline at end of file diff --git a/179/InvasionFront_CD3_block15_x4_y3_patient179_1.json b/179/InvasionFront_CD3_block15_x4_y3_patient179_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8d7e543d1fe401793d7137ebd4f0b80bce2db6a2 --- /dev/null +++ b/179/InvasionFront_CD3_block15_x4_y3_patient179_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15391.9, + "Centroid Y µm": 17340.8, + "Num Detections": 16904, + "Num Negative": 15986, + "Num Positive": 918, + "Positive %": 5.431, + "Num Positive per mm^2": 377.75 + } +} \ No newline at end of file diff --git a/179/InvasionFront_CD8_block15_x3_y3_patient179_0.json b/179/InvasionFront_CD8_block15_x3_y3_patient179_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7fc68bea51f22d57147476cf53e4df66bd6fc83e --- /dev/null +++ b/179/InvasionFront_CD8_block15_x3_y3_patient179_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11042.1, + "Centroid Y µm": 7418.0, + "Num Detections": 17484, + "Num Negative": 15721, + "Num Positive": 1763, + "Positive %": 10.08, + "Num Positive per mm^2": 718.68 + } +} \ No newline at end of file diff --git a/179/InvasionFront_CD8_block15_x4_y3_patient179_1.json b/179/InvasionFront_CD8_block15_x4_y3_patient179_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9c91c2e6b0d1bd97c248d97f4a0b6c22e5785216 --- /dev/null +++ b/179/InvasionFront_CD8_block15_x4_y3_patient179_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13694.1, + "Centroid Y µm": 7320.2, + "Num Detections": 15347, + "Num Negative": 14448, + "Num Positive": 899, + "Positive %": 5.858, + "Num Positive per mm^2": 382.59 + } +} \ No newline at end of file diff --git a/179/TumorCenter_CD3_block15_x3_y3_patient179_0.json b/179/TumorCenter_CD3_block15_x3_y3_patient179_0.json new file mode 100644 index 0000000000000000000000000000000000000000..64c9449b6d9f0ec0a9b912a7469c93f14363abb3 --- /dev/null +++ b/179/TumorCenter_CD3_block15_x3_y3_patient179_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 10744.3, + "Num Detections": 19874, + "Num Negative": 18821, + "Num Positive": 1053, + "Positive %": 5.298, + "Num Positive per mm^2": 425.4 + } +} \ No newline at end of file diff --git a/179/TumorCenter_CD3_block15_x4_y3_patient179_1.json b/179/TumorCenter_CD3_block15_x4_y3_patient179_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65fa30956895515a4f80d75b8a1060d475cfcb6e --- /dev/null +++ b/179/TumorCenter_CD3_block15_x4_y3_patient179_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13917.6, + "Centroid Y µm": 10719.3, + "Num Detections": 17312, + "Num Negative": 16526, + "Num Positive": 786, + "Positive %": 4.54, + "Num Positive per mm^2": 324.06 + } +} \ No newline at end of file diff --git a/179/TumorCenter_CD8_block15_x3_y3_patient179_0.json b/179/TumorCenter_CD8_block15_x3_y3_patient179_0.json new file mode 100644 index 0000000000000000000000000000000000000000..671d20a968e4087f7cc5d8ebf46f83a544df427a --- /dev/null +++ b/179/TumorCenter_CD8_block15_x3_y3_patient179_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 7446.1, + "Num Detections": 17164, + "Num Negative": 15526, + "Num Positive": 1638, + "Positive %": 9.543, + "Num Positive per mm^2": 672.9 + } +} \ No newline at end of file diff --git a/179/TumorCenter_CD8_block15_x4_y3_patient179_1.json b/179/TumorCenter_CD8_block15_x4_y3_patient179_1.json new file mode 100644 index 0000000000000000000000000000000000000000..097549e7e0e22694b1519c751fdd5a83444b821f --- /dev/null +++ b/179/TumorCenter_CD8_block15_x4_y3_patient179_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 7396.1, + "Num Detections": 19676, + "Num Negative": 18342, + "Num Positive": 1334, + "Positive %": 6.78, + "Num Positive per mm^2": 558.13 + } +} \ No newline at end of file diff --git a/179/history_text.txt b/179/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4cf8cee541f6a2a71b9ef856b82a094745cc48ef --- /dev/null +++ b/179/history_text.txt @@ -0,0 +1 @@ +The patient has a right tongue carcinoma after external sampling. Histologically G3. There is an exophytic superficial mass on the tip of the tongue/edge of the tongue on the right. The ultrasound examination showed a cN0 neck status with a lymph node level Ib on the right that was worth checking. The tumor could not be visualized in the CT scan due to its superficiality and dental artifacts. No lymph node metastases. An unclear multiple sclerosis in the processus spinosus of BWK 1 is described, here DD osteoma, DD osteoplastic metastasis and scintigraphic correlate recommended. Based on the medical history and clinical findings, indication for the above-mentioned procedure. No toxins. \ No newline at end of file diff --git a/179/icd_codes.txt b/179/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf422e8d9567fdb2464b75d4b6093c8a641ac4db --- /dev/null +++ b/179/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 R] \ No newline at end of file diff --git a/179/ops_codes.txt b/179/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4dc344ede1bbecea58c6e705b0ca4fce7c6ac01b --- /dev/null +++ b/179/ops_codes.txt @@ -0,0 +1 @@ +Keilresektion der Zunge[5-250.2 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie: Bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/179/patient_clinical_data.json b/179/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d79a4a9d80e91abfd90c209c6a00767a256ccd64 --- /dev/null +++ b/179/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 78, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/179/patient_pathological_data.json b/179/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c6b1c3a83c89d11b7157f612ab9c3056d528e956 --- /dev/null +++ b/179/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "179", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/179/surgery_description.txt b/179/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..386111ef151f88bf7436ece8b6910cefd464606e --- /dev/null +++ b/179/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy diff --git a/179/surgery_report.txt b/179/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4e83eab4c0839d6b138312dc5ede6f337cb5addb --- /dev/null +++ b/179/surgery_report.txt @@ -0,0 +1 @@ +First, transfer the patient to the operating theater. Then active patient identification and team time out as well as consultation with anesthesia colleagues. Then induction of anesthesia and tracheoscopy with the aid of the laryngeal spatula by the surgeon. The glottic plane, vocal folds, subglottic area, entire trachea up to the carina are unremarkable. Now intubation by the anesthetist and deepening of the anesthesia. Then transition to esophagogastroscopy. Careful insertion of the flexible endoscope with the aid of the laryngeal spatula under air insufflation. Pre-viewing into the stomach. Inversion here. Inconspicuous mucosal conditions everywhere. Air desufflation and retraction of the endoscope everywhere. Inconspicuous mucosal conditions in the entire esophagus. Now transition to laryngoscopy/pharyngoscopy: The surgeon positions the head and enters the oropharynx with the Kleinsasser tube type C. The tonsils, base of the tongue, vallecula, aryepiglottic folds on both sides, arytenoid cartilage on both sides, piriform sinus on both sides, interary area, postcricoid area and glottic plane are unremarkable. No evidence of a secondary tumor. Palpation of the tonsils and the base of the tongue, vallecula clear. Inspection of the oral cavity and floor of the mouth. No suspicious mass except for the previously described exophytic, superficially growing mass on the anterior right edge of the tongue with a longitudinal diameter of approx. 1 ˝ cm and a transverse diameter of 1 cm. Growing superficially on palpation. Now insertion of the spandex and rein suture. Insertion in the area of the raphe, thereby dislocating the tongue anteriorly and laterally. Now mark the resection margins with the monopolar with a safety margin of more than 1 cm. Demonstration on . Successive resection of the tumor along the resection margins using bipolar coagulation and pointed scissors. Meticulous hemostasis is performed. The tumor is resected in toto with a sufficient safety margin of more than 1 cm, suture marking short short tongue tip anterior, short long tongue dorsum, long long tongue margin right and wound base. The preparation is sent for final histology. Re-inspection of the surgical site. Repeated bipolar coagulation, also in depth. Absolutely dry wound conditions. No further bleeding. Intraoperative administration of 250 mg SDH, head repositioning by the surgeon and completion of the procedure without complications. Conclusion: Externally histologically confirmed cT1 cN0 G3 tongue margin carcinoma anterior right. Enoral resection. This goes to final histology. Waiting for the final histology and presentation at the tumor conference. In the case of lymph nodes worthy of checking at level Ib and a scintigraphic mass requiring clarification BWK 1. \ No newline at end of file diff --git a/180/InvasionFront_CD3_block15_x5_y6_patient180_0.json b/180/InvasionFront_CD3_block15_x5_y6_patient180_0.json new file mode 100644 index 0000000000000000000000000000000000000000..946a4fcaad6bb5d86bda45baa7b80753c409bbf0 --- /dev/null +++ b/180/InvasionFront_CD3_block15_x5_y6_patient180_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 24711.9, + "Num Detections": 18476, + "Num Negative": 17470, + "Num Positive": 1006, + "Positive %": 5.445, + "Num Positive per mm^2": 417.07 + } +} \ No newline at end of file diff --git a/180/InvasionFront_CD3_block15_x6_y6_patient180_1.json b/180/InvasionFront_CD3_block15_x6_y6_patient180_1.json new file mode 100644 index 0000000000000000000000000000000000000000..29b00c66e05822508c137ef1745ff6354c764710 --- /dev/null +++ b/180/InvasionFront_CD3_block15_x6_y6_patient180_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20938.9, + "Centroid Y µm": 24512.0, + "Num Detections": 18984, + "Num Negative": 17638, + "Num Positive": 1346, + "Positive %": 7.09, + "Num Positive per mm^2": 576.17 + } +} \ No newline at end of file diff --git a/180/InvasionFront_CD8_block15_x5_y6_patient180_0.json b/180/InvasionFront_CD8_block15_x5_y6_patient180_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3dbe42a421afb9b11ab546e9d649a5db0e772838 --- /dev/null +++ b/180/InvasionFront_CD8_block15_x5_y6_patient180_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16336.3, + "Centroid Y µm": 14583.1, + "Num Detections": 16694, + "Num Negative": 16146, + "Num Positive": 548, + "Positive %": 3.283, + "Num Positive per mm^2": 240.69 + } +} \ No newline at end of file diff --git a/180/InvasionFront_CD8_block15_x6_y6_patient180_1.json b/180/InvasionFront_CD8_block15_x6_y6_patient180_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ebdd947b2950928fea76be33c0e4b53ba2e78e99 --- /dev/null +++ b/180/InvasionFront_CD8_block15_x6_y6_patient180_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18956.0, + "Centroid Y µm": 14538.3, + "Num Detections": 15106, + "Num Negative": 14140, + "Num Positive": 966, + "Positive %": 6.395, + "Num Positive per mm^2": 455.62 + } +} \ No newline at end of file diff --git a/180/TumorCenter_CD3_block15_x5_y6_patient180_0.json b/180/TumorCenter_CD3_block15_x5_y6_patient180_0.json new file mode 100644 index 0000000000000000000000000000000000000000..97d118bf60b8ce76243e16643f4437c4bb6d1f18 --- /dev/null +++ b/180/TumorCenter_CD3_block15_x5_y6_patient180_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 18390.3, + "Num Detections": 14481, + "Num Negative": 13833, + "Num Positive": 648, + "Positive %": 4.475, + "Num Positive per mm^2": 283.62 + } +} \ No newline at end of file diff --git a/180/TumorCenter_CD3_block15_x6_y6_patient180_1.json b/180/TumorCenter_CD3_block15_x6_y6_patient180_1.json new file mode 100644 index 0000000000000000000000000000000000000000..216cc36db1318f440b91251b16d00a004bc028c8 --- /dev/null +++ b/180/TumorCenter_CD3_block15_x6_y6_patient180_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 18390.3, + "Num Detections": 14611, + "Num Negative": 14068, + "Num Positive": 543, + "Positive %": 3.716, + "Num Positive per mm^2": 237.81 + } +} \ No newline at end of file diff --git a/180/TumorCenter_CD8_block15_x5_y6_patient180_0.json b/180/TumorCenter_CD8_block15_x5_y6_patient180_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de904731bfd60b770c1b5bc3c5c6a1094a003021 --- /dev/null +++ b/180/TumorCenter_CD8_block15_x5_y6_patient180_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 14917.1, + "Num Detections": 17997, + "Num Negative": 17421, + "Num Positive": 576, + "Positive %": 3.201, + "Num Positive per mm^2": 254.82 + } +} \ No newline at end of file diff --git a/180/TumorCenter_CD8_block15_x6_y6_patient180_1.json b/180/TumorCenter_CD8_block15_x6_y6_patient180_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5b6da59ed74d02b4d4db590cb84b7fa5369506c5 --- /dev/null +++ b/180/TumorCenter_CD8_block15_x6_y6_patient180_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21463.6, + "Centroid Y µm": 14867.1, + "Num Detections": 18987, + "Num Negative": 18478, + "Num Positive": 509, + "Positive %": 2.681, + "Num Positive per mm^2": 227.47 + } +} \ No newline at end of file diff --git a/180/history_text.txt b/180/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..103a8e71bf07f3a5347ddf733eece3dae3f08e6a --- /dev/null +++ b/180/history_text.txt @@ -0,0 +1 @@ +The patient underwent a panendoscopy <2014>. This revealed a cT2 tongue margin carcinoma on the right. Initially, induction chemotherapy was performed, as the patient was very reluctant to undergo surgery. Induction chemotherapy resulted in only minimal tumor reduction macroscopically and no metabolic reduction in the PET-CT. The decision was therefore made to proceed with definitive surgical treatment. \ No newline at end of file diff --git a/180/icd_codes.txt b/180/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..82116483c669243d1df627860c6f04a383b4e649 --- /dev/null +++ b/180/icd_codes.txt @@ -0,0 +1 @@ +Karzinom des Mundrachenraums[C14.8 R] \ No newline at end of file diff --git a/180/ops_codes.txt b/180/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85ef5d65491000b9ea53c7e5d6f03427102bc1fe --- /dev/null +++ b/180/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Plastische Rekonstruktion mit fasziokutanem Lappen Unterarm[5-857.03 L] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle sonstige Teile Kopf[5-905.04 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Wechsel eines vaskulären Implantates[5-394.3 ] Muskellappenplastik am Kopf[5-857.80 L] \ No newline at end of file diff --git a/180/patient_clinical_data.json b/180/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4c08780e0e9c3d99591977513858271667f8119b --- /dev/null +++ b/180/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 52, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 122, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": "cisplatin + Docetaxel", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/180/patient_pathological_data.json b/180/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ff0afdeae659e8b31ccb901ed0523258dab6b628 --- /dev/null +++ b/180/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "180", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 28.0 +} \ No newline at end of file diff --git a/180/surgery_description.txt b/180/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d6bfd4964ea7a0ca3017fe670d0013fe029d491 --- /dev/null +++ b/180/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheotomy, Defect coverage diff --git a/180/surgery_report.txt b/180/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0f64ec95676192193f0032bdebdd8e31876129ef --- /dev/null +++ b/180/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia. Intubation by anesthesia colleagues. Sterile washing and draping. Insertion of a covered retractor into the mouth and spandex. Inspection of the tongue. There is an exophytic mass in the area of the right edge of the tongue. The mass is clearly progressive. It spreads far beyond the midline to the left side. The tumor extends palpatorily to the other side, especially in the middle and posterior part of the tongue. Add and . The decision is made to perform the operation by means of complete tumor removal despite the significant progression of the tumor. Incision of the mucosa with the monopolar needle and successive resection of the tumor with a safety margin of at least 1 cm. The ultrasonic knife as well as conventional scissors and bipolar forceps are used for this. Only a narrow strip of mucosa remains in the area of the left base of the tongue. In this area, a complete centimeter safety margin is not possible without removing this remaining strip of mucosa. More tissue remains at the tip of the tongue. During tumor resection, the lingual artery is shown on the left side. It can be clearly seen that this artery also extends into the tumor. Consult again. It is decided to continue the tumor resection, also removing the lingual artery on the left side. A resection must also be performed for this in order to ultimately achieve an R0 situation in this area as well. In the area of the base of the tongue, a sufficient overview cannot be guaranteed from the transoral approach. Therefore, repositioning for neck dissection. Creation of an apron flap. Neck dissection is performed on the right side, exposing the sternocleidomastoid, omohyoid and digaster muscles and the submandibular gland. Exposure of the cervical vascular sheath. Free preparation of the internal jugular vein, the facial vein and the accessorius nerve. Release of the neck preparation IIa to Va while sparing the plexus branches. Separation of the digaster venter posterior muscle. Palpation of the tumor and further tumor resection from transcervical using the pull-through technique. The tumor also involves the hyoid bone and the submandibular gland on the right side. These structures are removed en bloc with the tumor resectate. Removal of marginal samples from the specimen and sending for frozen section. Removal of two additional resected specimens, which may have been resected with a macroscopic margin. All margin samples and all resected specimens are tumor-free in the frozen section. Final R0 situation. Consultation of and demonstration of findings. Joint planning of defect reconstruction using Remmert flap and radial artery graft. Working in a two-team procedure. and perform the neck dissection on the left side. Exposure of the sternocleidmastoid muscle, omohyoid muscle and digastric muscle, submandibular gland, exposure of the cervical vascular sheath. Free preparation of the internal jugular vein, the facial vein and the superior thyroid artery. Release of the neck preparation level IIa to Va while protecting the plexus branches. Lifting of the Remmert flap. Exposure of the infrahyal musculature for this purpose. Detachment of the infrahyal musculature and release of the superior thyroid artery and the facial vein. The Remmert flap remains pedicled on the superior thyroid artery and accompanying veins of the facial vein so that it can be loosely turned upwards. Parallel to the neck dissection and elevation of the Remmert flap, elevate the radial artery graft from the left. Mark the graft for this purpose. The graft is 16x9 cm in size. Skin incision and visualization of the brachioradialis muscle. Depiction of the vein star in the elbow. Depiction of a superficial vein. The cephalic vein is shown in the center. Showing the ramus superficialis nervi radialis, which is divided into several branches. Visualization of these branches. Locating and exposing the radial artery. Ligating and bypassing the radial artery. Detachment of the graft from the tendons. Dissection of the pedicle with bipolar coagulation and clipping of the branches up to the elbow. Exposure of the concomitant vein and the venous confluence between the superficial and deep system in the elbow. The concomitant veins are exposed and elevated in a confluence as well as a vein of the superficial system and the confluence marking of the radial artery. Deposition of the graft. Transition to suturing of the graft. Positioning of the flap from cervical to enoral. First fixation of the graft on the remaining tongue remnant. Transition to the neck and closure of the pharyngeal defect by placing sutures. Suturing of the graft enorally on the tongue remnant and the floor of the mouth. The flap must be rotated once to achieve three-dimensional closure of the defect. This is difficult, but is ultimately successful. Dissection at the neck of the superior thyroid artery and conditioning of this and the radial artery. Suturing the anastomosis of the two arteries. This is very problematic as the vascular situation in the neck is critical due to plaques and the blood supply to the graft is initially not fully guaranteed. An anastomosis with a long-term flowing lumen is only possible after the superior thyroid artery has been cut back several times. There is also significant reflux from the veins. Superficial and deep veins are couplerized. Perform the tracheotomy through and at the same time as lifting the radial artery graft. For this, insertion between the 2nd and 3rd tracheal cartilage. Creation of a Björ flap. Creation of a mucocutaneous anastomosis. At the end, creation of a mucocutaneous anastomosis in the tracheal region in the upper edge through the apron flap. Insertion of a Redon drain on the left side and a flap on the right side. After completion of the neck suture, it becomes apparent that the anastomosis on the right side is being pushed out by the skin closure. It was therefore decided to open this side again and to adapt it only slightly. Continuous perfusion of the graft is now possible. The patient goes to the IOI intubated and ventilated. Please continue antibiotics with Unacid 3 g 3 times a day and heparin 500 units/hour via a perfusor. Nutrition via the PEG tube already in place for 10 days. Then a clinical swallowing test and possibly an X-ray wide swallow. If swallowing is not possible in the long term and aspiration problems occur, a laryngectomy must be considered in the long term. \ No newline at end of file diff --git a/181/InvasionFront_CD3_block22_x5_y2_patient181_0.json b/181/InvasionFront_CD3_block22_x5_y2_patient181_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad1e9bb3d20d516b2cd14db8f951fb620445d639 --- /dev/null +++ b/181/InvasionFront_CD3_block22_x5_y2_patient181_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17415.8, + "Centroid Y µm": 16466.3, + "Num Detections": 20210, + "Num Negative": 20007, + "Num Positive": 203, + "Positive %": 1.004, + "Num Positive per mm^2": 102.5 + } +} \ No newline at end of file diff --git a/181/InvasionFront_CD3_block22_x6_y2_patient181_1.json b/181/InvasionFront_CD3_block22_x6_y2_patient181_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef2309c177259d68a9524b10b1b601c8c74c2ccc --- /dev/null +++ b/181/InvasionFront_CD3_block22_x6_y2_patient181_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19864.5, + "Centroid Y µm": 16491.3, + "Num Detections": 21225, + "Num Negative": 20984, + "Num Positive": 241, + "Positive %": 1.135, + "Num Positive per mm^2": 120.61 + } +} \ No newline at end of file diff --git a/181/InvasionFront_CD8_block22_x5_y2_patient181_0.json b/181/InvasionFront_CD8_block22_x5_y2_patient181_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d234251fe17cf6caf08c1ff4170ae66b031bb76a --- /dev/null +++ b/181/InvasionFront_CD8_block22_x5_y2_patient181_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 5047.3, + "Num Detections": 20016, + "Num Negative": 19858, + "Num Positive": 158, + "Positive %": 0.7894, + "Num Positive per mm^2": 81.21 + } +} \ No newline at end of file diff --git a/181/InvasionFront_CD8_block22_x6_y2_patient181_1.json b/181/InvasionFront_CD8_block22_x6_y2_patient181_1.json new file mode 100644 index 0000000000000000000000000000000000000000..507dce6bc493826268ca21cfa17abf2798763f21 --- /dev/null +++ b/181/InvasionFront_CD8_block22_x6_y2_patient181_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21363.7, + "Centroid Y µm": 4972.4, + "Num Detections": 19661, + "Num Negative": 19411, + "Num Positive": 250, + "Positive %": 1.272, + "Num Positive per mm^2": 129.83 + } +} \ No newline at end of file diff --git a/181/TumorCenter_CD3_block22_x5_y2_patient181_0.json b/181/TumorCenter_CD3_block22_x5_y2_patient181_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0bb8c02f32da4875eca308bcaa1747c7aa584d65 --- /dev/null +++ b/181/TumorCenter_CD3_block22_x5_y2_patient181_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 6221.7, + "Num Detections": 17940, + "Num Negative": 17888, + "Num Positive": 52, + "Positive %": 0.2899, + "Num Positive per mm^2": 26.65 + } +} \ No newline at end of file diff --git a/181/TumorCenter_CD3_block22_x6_y2_patient181_1.json b/181/TumorCenter_CD3_block22_x6_y2_patient181_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4c51e7539c39eed0bf94e400d2948a4c7a440e15 --- /dev/null +++ b/181/TumorCenter_CD3_block22_x6_y2_patient181_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 6396.6, + "Num Detections": 17017, + "Num Negative": 16969, + "Num Positive": 48, + "Positive %": 0.2821, + "Num Positive per mm^2": 25.11 + } +} \ No newline at end of file diff --git a/181/TumorCenter_CD8_block22_x5_y2_patient181_0.json b/181/TumorCenter_CD8_block22_x5_y2_patient181_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a2a4874003cf625598deb16aee8f3368b7c41894 --- /dev/null +++ b/181/TumorCenter_CD8_block22_x5_y2_patient181_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19289.8, + "Centroid Y µm": 15092.0, + "Num Detections": 18503, + "Num Negative": 18021, + "Num Positive": 482, + "Positive %": 2.605, + "Num Positive per mm^2": 250.82 + } +} \ No newline at end of file diff --git a/181/TumorCenter_CD8_block22_x6_y2_patient181_1.json b/181/TumorCenter_CD8_block22_x6_y2_patient181_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f653715a07c05e397bc36698ff5293e5f6fd0df --- /dev/null +++ b/181/TumorCenter_CD8_block22_x6_y2_patient181_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21713.5, + "Centroid Y µm": 15117.0, + "Num Detections": 18710, + "Num Negative": 18067, + "Num Positive": 643, + "Positive %": 3.437, + "Num Positive per mm^2": 335.29 + } +} \ No newline at end of file diff --git a/181/history_text.txt b/181/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f61a5f06e63e28dcf624105801eaefc477298ce --- /dev/null +++ b/181/history_text.txt @@ -0,0 +1 @@ +Diagnoses: cT3 laryngeal carcinoma right \ No newline at end of file diff --git a/181/icd_codes.txt b/181/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6fd121dc40d22b6fb46d31a947332bc01b0c9d --- /dev/null +++ b/181/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/181/ops_codes.txt b/181/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c814bc902649b69d3bb7177365399067600ae94 --- /dev/null +++ b/181/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Laryngektomie: Mit Pharyngektomie[5-303.1 ] Permanente Tracheostomie: Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/181/patient_clinical_data.json b/181/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..66b314597c94b8fc22a74e346d5323630b8d5f2e --- /dev/null +++ b/181/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/181/patient_pathological_data.json b/181/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a07c6957b3eed23b874327310572904fb53f0465 --- /dev/null +++ b/181/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "181", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/181/surgery_description.txt b/181/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6d965579f0e8017db1b4143a51560b4cea927b39 --- /dev/null +++ b/181/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, PEG, Bilateral neck dissection, Tracheotomy diff --git a/181/surgery_report.txt b/181/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..695c3fb1746de6eafb7a9dfeb44bb54271c8a855 --- /dev/null +++ b/181/surgery_report.txt @@ -0,0 +1 @@ +Surgeons: , The patient has a histologically confirmed laryngeal carcinoma. The preoperative laryngoscopy shows that the tumor extends supraglottically to the right side of the ary, consuming the laryngeal epiglottis and growing endolaryngeally on the opposite side. A PEG tube is now placed in the typical manner. First insertion with the flexible gastroscope through the esophagus into the stomach. Then diaphanoscopy in the area of the stomach on the left in the area of the left costal arch and then percutaneous puncture and then placement of the trocar and a PEG tube is placed via this in a typical manner using the thread pull-through method. A gastric tube is then placed. Now form an apron flap. This is lifted at the level of the hyoid bone and fixed in place. A neck dissection is then performed on the right. Expose the front edge of the sternocleidomastoid muscle. Exposure of the cervical vascular sheath (common carotid artery, jugular vein, vagus nerve). Caudal of the neck dissection preparation is now dissected cranially for approx. 2 cm. The accessorius nerve is now exposed cranially. The digastric muscle and the hypoglossal nerve are overlaid by a large metastasis, which is carefully removed from the surrounding connective tissue and the jugular tissue. The hypoglossal nerve is then safely identified. The lateral neck dissection specimen is now developed and removed from cranial to caudal while protecting the cervical nerve plexus as much as possible. Now the medial part of the common carotid artery is exposed and the bifurcation is sought out and the external carotid artery is traced further. Identification of the superior thyroid artery. Clamp it, cut it and then ligate it. The medial neck dissection preparation is now completed. Now move to the opposite side. Perform the left neck dissection. Exposure of the anterior edge of the sternocleidomastoid muscle. Caudal exposure of the common carotid artery, the jugular vein and the vagus nerve. The neck dissection specimen is now placed laterally at the level of the omohyoid muscle and developed approx. 2 to 3 cm cranially. The accessorius nerve, the hypoglossal nerve and the digastric muscle are now identified cranially. The lateral neck dissection preparation is now developed from cranial to caudal. The neck dissection is now completed medially and the common carotid artery is shown. The carotid bifurcation is identified. The external carotid artery is further traced with the superior thyroid artery clamped, severed and ligated. The hyoid bone is then sought out and freed from surrounding connective and fatty tissue. The prelaryngeal muscles (sternohyoid and thyrohyoid muscles) are dissected ventrally up to the level of the supraclavicular region. The hyoid bone is then removed in toto. The posterior horn of the thyroid cartilage is then identified. Identification of the vascular nerve bundle (superior laryngeal artery and the vein accompanying the superior laryngeal nerve) are identified on both sides, clamped, severed and ligated. The hypopharynx is then bluntly released from the thyroid cartilage on both sides. The larynx is then mobilized laterally. The tracheotomy is now performed. Identification of the thyroid isthmus. Clamp it and stop it. The trachea is incised transversely at the level of the 3rd/4th tracheal cartilage and the trachea is fixed caudally to the skin. Now enter the pharyngeal tube. Identification of the epiglottis, which is dislocated. This reveals the tumorous infiltration described above. The larynx is now incised along the aryepiglottic fold on the right and left. The two incisions are now joined below the arytenoid region. Now develop the hypopharyngeal tube and tilt the larynx ventrally. The trachea is then cut out cranially in the form of a tongue. Careful hemostasis is then performed. Samples are taken from the edges for frozen section diagnosis (circular incision around the defect and marking of the defect). The frozen section diagnosis does not reveal any evidence of carcinoma infiltration, so that an R0 situation can be assumed in the present case. Placement of TachoComp, followed by suturing of the muscle layer above the pharyngeal tube. The prelaryngeal musculature is readapted. Subsequent careful irrigation of the wound. Placement of Redon drains. Subcutaneous suture. Skin suture. Suturing of the tracheostoma. It is now apparent that there is probably a dermal nevus on the right supraclavicular side, which is incised and sent for histopathological processing. A tracheostomy tube was then placed. The patient is then admitted to the intensive care unit postoperatively. F a c i t : Laryngectomy, neck dissection on both sides for cT3 laryngeal carcinoma on the right. After receiving the histology, the patient should be presented to the interdisciplinary tumor conference for evaluation of postoperative radiotherapy or radiochemotherapy. \ No newline at end of file diff --git a/182/InvasionFront_CD3_block15_x3_y7_patient182_0.json b/182/InvasionFront_CD3_block15_x3_y7_patient182_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6b3de5959f01f22ac5aaca256c0b8caadf2f4e53 --- /dev/null +++ b/182/InvasionFront_CD3_block15_x3_y7_patient182_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 27460.5, + "Num Detections": 16103, + "Num Negative": 15185, + "Num Positive": 918, + "Positive %": 5.701, + "Num Positive per mm^2": 413.76 + } +} \ No newline at end of file diff --git a/182/InvasionFront_CD3_block15_x4_y7_patient182_1.json b/182/InvasionFront_CD3_block15_x4_y7_patient182_1.json new file mode 100644 index 0000000000000000000000000000000000000000..72e840c107a33b9c72240d2c9772ebfd6b771139 --- /dev/null +++ b/182/InvasionFront_CD3_block15_x4_y7_patient182_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 27410.5, + "Num Detections": 11581, + "Num Negative": 10284, + "Num Positive": 1297, + "Positive %": 11.2, + "Num Positive per mm^2": 860.64 + } +} \ No newline at end of file diff --git a/182/InvasionFront_CD8_block15_x3_y7_patient182_0.json b/182/InvasionFront_CD8_block15_x3_y7_patient182_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d569c99469a61a61925a7417114e782221b37a9b --- /dev/null +++ b/182/InvasionFront_CD8_block15_x3_y7_patient182_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11292.5, + "Centroid Y µm": 17065.9, + "Num Detections": 14426, + "Num Negative": 13867, + "Num Positive": 559, + "Positive %": 3.875, + "Num Positive per mm^2": 252.6 + } +} \ No newline at end of file diff --git a/182/InvasionFront_CD8_block15_x4_y7_patient182_1.json b/182/InvasionFront_CD8_block15_x4_y7_patient182_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0e51fe632b5f38a1e26bf9bebd1b6dfb3a41c469 --- /dev/null +++ b/182/InvasionFront_CD8_block15_x4_y7_patient182_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13916.9, + "Centroid Y µm": 17044.1, + "Num Detections": 17690, + "Num Negative": 16700, + "Num Positive": 990, + "Positive %": 5.596, + "Num Positive per mm^2": 421.19 + } +} \ No newline at end of file diff --git a/182/TumorCenter_CD3_block15_x3_y7_patient182_0.json b/182/TumorCenter_CD3_block15_x3_y7_patient182_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3632112dcdcf4f29ddf1b069552bf6e4506769f7 --- /dev/null +++ b/182/TumorCenter_CD3_block15_x3_y7_patient182_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 20888.9, + "Num Detections": 11954, + "Num Negative": 11878, + "Num Positive": 76, + "Positive %": 0.6358, + "Num Positive per mm^2": 40.74 + } +} \ No newline at end of file diff --git a/182/TumorCenter_CD3_block15_x4_y7_patient182_1.json b/182/TumorCenter_CD3_block15_x4_y7_patient182_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b224907c5601b5980e0d8bb72ba54ba03b136032 --- /dev/null +++ b/182/TumorCenter_CD3_block15_x4_y7_patient182_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 20913.9, + "Num Detections": 13956, + "Num Negative": 13448, + "Num Positive": 508, + "Positive %": 3.64, + "Num Positive per mm^2": 261.92 + } +} \ No newline at end of file diff --git a/182/TumorCenter_CD8_block15_x3_y7_patient182_0.json b/182/TumorCenter_CD8_block15_x3_y7_patient182_0.json new file mode 100644 index 0000000000000000000000000000000000000000..924c8467ac41d0f848f344f7baa854594696691d --- /dev/null +++ b/182/TumorCenter_CD8_block15_x3_y7_patient182_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 17440.8, + "Num Detections": 15893, + "Num Negative": 15839, + "Num Positive": 54, + "Positive %": 0.3398, + "Num Positive per mm^2": 25.64 + } +} \ No newline at end of file diff --git a/182/TumorCenter_CD8_block15_x4_y7_patient182_1.json b/182/TumorCenter_CD8_block15_x4_y7_patient182_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c262b968755c8457c1068cc971753a5a6b324d36 --- /dev/null +++ b/182/TumorCenter_CD8_block15_x4_y7_patient182_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 17465.8, + "Num Detections": 15177, + "Num Negative": 14941, + "Num Positive": 236, + "Positive %": 1.555, + "Num Positive per mm^2": 109.23 + } +} \ No newline at end of file diff --git a/182/history_text.txt b/182/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6d1910f03d3fee2a48179683dfba04faead942f9 --- /dev/null +++ b/182/history_text.txt @@ -0,0 +1 @@ +A sample was taken from the left edge of the patient's tongue <2014>. No evidence of malignancy here, only leukoplakia. Then, with progression of the mass, new sampling and panendoscopy <2014>, therefore indication for tumor resection. The tumor is now clearly progressive. \ No newline at end of file diff --git a/182/icd_codes.txt b/182/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/182/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/182/ops_codes.txt b/182/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d6bec6a68d78b3be8ac0e8db53095f5a763594a1 --- /dev/null +++ b/182/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Mundbodenteilresektion[5-273.6 ] Laterale Pharyngotomie[5-290.3 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 L] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Wechsel eines vaskulären Implantates[5-394.3 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e L] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] \ No newline at end of file diff --git a/182/patient_clinical_data.json b/182/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4b18ae73b0bf0356ce2ec610ecc22aca2c072cb3 --- /dev/null +++ b/182/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 53, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/182/patient_pathological_data.json b/182/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..76bd70f6395dc5aeabb3bb24f5f202d679613c77 --- /dev/null +++ b/182/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "182", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/182/surgery_description.txt b/182/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..019d9de78bdb4a00ad2efb61639d02469a204484 --- /dev/null +++ b/182/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection diff --git a/182/surgery_report.txt b/182/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf20a5ece36a3e53c5f05e6331fd8b5ec2249f74 --- /dev/null +++ b/182/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by anesthesia colleagues. Performing flexible oesophagoscopy and gastroscopy and inserting a PEG using the thread pull-through method. This can be done without any problems with good diaphanoscopy. Insertion of a covered retractor and looping of the tongue. Inspection of the tumor. A tumor at least 4 cm in size can be seen on the middle third of the tongue margin. The tumor extends to the floor of the mouth, but does not involve the anterior floor of the mouth or the base of the tongue. Incision of the mucosa using a monopolar needle with a safety margin of 1 to 1.5 cm. Removal of the tumor using scissors, bipolar forceps and palpation. The tumor penetrates deep down to the midline of the tongue. The tumor can be removed in its entirety. The tumor preparation is thread-marked in its entirety for frozen section. This is clearly an R0 situation. Due to the large resulting defect, the decision was made to cover the defect with a radialis graft to improve function. Therefore neck dissection on the left side. Neck dissection on the right side is not performed due to the lack of infiltration of the base of the tongue and anterior floor of the mouth and a cN0 neck status on the right side. Transverse neck incision. Exposure of the platysma. Formation of a cranial and caudal platysma flap. Exposure of the sternocleidomastoid muscle, the omohyoid muscle and the posterior belly of the digaster and the submandibular gland. Release of the neck preparation Leves II a/b as well as III, IV and V, while sparing the plexus branches. Level V is integrated into the neck preparation, as some lymph nodes could be found here. Release of the submandibular gland and removal of fatty tissue in level I b. Dissection of the digastric muscle and formation of an enoral tunnel. Lifting the radialis graft. Drawing of the radial artery. Marking of the graft. Cutting around the graft. Incision of the skin up to the crook of the elbow. Exposure of the brachioradialis muscle. Exposure of the venous star in the antecubital fossa with basilic vein, cephalic vein and the confluence between the superficial and deep venous system. Exposure of the superficial ramus, the radial nerve with its splitting. This can be completely preserved. Exposure of the radial artery. Ligating and separating the radial artery. Release of the skin flap by exposing the tendons of the forearm. Dissection of the pedicle up to the crook of the elbow. Removal of the confluence. Marking of vein and artery. Closure of the forearm using split skin from the right thigh. Suturing of the graft. Pulling the graft through enorally. Suturing of the graft both in the tongue area and in the floor of the mouth. Repositioning of the patient to perform the vascular anastomosis. Conditioning of the superior thyroid artery and the facial vein. First the arterial anastomosis is performed, then the venous anastomosis using a size 4 coupler. Insertion of a Redon drain and two-layer wound closure. Completion of the operation without complications. There is good blood flow to the graft at the end of the operation. The patient is ventilated and admitted to the intensive care unit. \ No newline at end of file diff --git a/183/InvasionFront_CD3_block20_x5_y9_patient183_0.json b/183/InvasionFront_CD3_block20_x5_y9_patient183_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d8c0cf3aec619e8e9fa3e2bc071c95ff2a4d126c --- /dev/null +++ b/183/InvasionFront_CD3_block20_x5_y9_patient183_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 22613.0, + "Num Detections": 20246, + "Num Negative": 18867, + "Num Positive": 1379, + "Positive %": 6.811, + "Num Positive per mm^2": 599.77 + } +} \ No newline at end of file diff --git a/183/InvasionFront_CD3_block20_x6_y9_patient183_1.json b/183/InvasionFront_CD3_block20_x6_y9_patient183_1.json new file mode 100644 index 0000000000000000000000000000000000000000..14c654b31b2dc464467eeb601542eabac60e9aac --- /dev/null +++ b/183/InvasionFront_CD3_block20_x6_y9_patient183_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19139.9, + "Centroid Y µm": 22937.9, + "Num Detections": 18996, + "Num Negative": 15505, + "Num Positive": 3491, + "Positive %": 18.38, + "Num Positive per mm^2": 1492.3 + } +} \ No newline at end of file diff --git a/183/InvasionFront_CD8_block20_x5_y9_patient183_0.json b/183/InvasionFront_CD8_block20_x5_y9_patient183_0.json new file mode 100644 index 0000000000000000000000000000000000000000..de3e129a44f3fdab5cb0a8f1767aefa6b3a119e4 --- /dev/null +++ b/183/InvasionFront_CD8_block20_x5_y9_patient183_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17290.8, + "Centroid Y µm": 22363.2, + "Num Detections": 19982, + "Num Negative": 19418, + "Num Positive": 564, + "Positive %": 2.823, + "Num Positive per mm^2": 261.43 + } +} \ No newline at end of file diff --git a/183/InvasionFront_CD8_block20_x6_y9_patient183_1.json b/183/InvasionFront_CD8_block20_x6_y9_patient183_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f9ec0011c85319709e7dd43756096ce11ac70213 --- /dev/null +++ b/183/InvasionFront_CD8_block20_x6_y9_patient183_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19814.5, + "Centroid Y µm": 22313.2, + "Num Detections": 18260, + "Num Negative": 16601, + "Num Positive": 1659, + "Positive %": 9.085, + "Num Positive per mm^2": 715.93 + } +} \ No newline at end of file diff --git a/183/TumorCenter_CD3_block20_x5_y9_patient183_0.json b/183/TumorCenter_CD3_block20_x5_y9_patient183_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e44887472ed1563b27a001e27db8b85eb3e3c40f --- /dev/null +++ b/183/TumorCenter_CD3_block20_x5_y9_patient183_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16286.4, + "Centroid Y µm": 21579.8, + "Num Detections": 21194, + "Num Negative": 19576, + "Num Positive": 1618, + "Positive %": 7.634, + "Num Positive per mm^2": 666.73 + } +} \ No newline at end of file diff --git a/183/TumorCenter_CD3_block20_x6_y9_patient183_1.json b/183/TumorCenter_CD3_block20_x6_y9_patient183_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a92d73154fe2ebca03b10a85b3467129d7cedb86 --- /dev/null +++ b/183/TumorCenter_CD3_block20_x6_y9_patient183_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18748.1, + "Centroid Y µm": 21624.9, + "Num Detections": 21877, + "Num Negative": 19623, + "Num Positive": 2254, + "Positive %": 10.3, + "Num Positive per mm^2": 974.24 + } +} \ No newline at end of file diff --git a/183/TumorCenter_CD8_block20_x5_y9_patient183_0.json b/183/TumorCenter_CD8_block20_x5_y9_patient183_0.json new file mode 100644 index 0000000000000000000000000000000000000000..548cfc8a029ade32ee755f3ed65c97b96d3a3ad8 --- /dev/null +++ b/183/TumorCenter_CD8_block20_x5_y9_patient183_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 22288.2, + "Num Detections": 23882, + "Num Negative": 22389, + "Num Positive": 1493, + "Positive %": 6.252, + "Num Positive per mm^2": 579.05 + } +} \ No newline at end of file diff --git a/183/TumorCenter_CD8_block20_x6_y9_patient183_1.json b/183/TumorCenter_CD8_block20_x6_y9_patient183_1.json new file mode 100644 index 0000000000000000000000000000000000000000..158f93a13396764097c50e14fdb8ac4f3a7c0a2e --- /dev/null +++ b/183/TumorCenter_CD8_block20_x6_y9_patient183_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 22238.2, + "Num Detections": 23066, + "Num Negative": 21518, + "Num Positive": 1548, + "Positive %": 6.711, + "Num Positive per mm^2": 646.58 + } +} \ No newline at end of file diff --git a/183/history_text.txt b/183/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e757717a95784ba03465d53b81b3c4e4aece5817 --- /dev/null +++ b/183/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed glottic carcinoma on the left. The above-mentioned operation was therefore indicated. \ No newline at end of file diff --git a/183/icd_codes.txt b/183/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/183/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/183/ops_codes.txt b/183/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/183/patient_clinical_data.json b/183/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..39843ad8bf8127addb2a561234c003091ea0724b --- /dev/null +++ b/183/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 66, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/183/patient_pathological_data.json b/183/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6003fa448ab4e9de74c694f8b2687f0152bce69e --- /dev/null +++ b/183/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "183", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/183/surgery_description.txt b/183/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b45ea1174e5848dbc7e53358c76517376cec36f6 --- /dev/null +++ b/183/surgery_description.txt @@ -0,0 +1 @@ +Laser resection diff --git a/183/surgery_report.txt b/183/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c7a338a8c23eb1f6c01e91eb4e9712ccd0c44dc5 --- /dev/null +++ b/183/surgery_report.txt @@ -0,0 +1 @@ +First insertion of the Kleinsasser tube size C. Expose the tumor. Cut around the tumor with a safety margin of several mm on all sides. For this purpose, a part of the dorsal pocket fold must be removed for a better overview. Also cranially, above the anterior commissure, a small part of the supraglottic region. This is resected en bloc with the tumor and a short section of the right vocal fold in front. Resection is performed anteriorly, taking the perichondrium with it and exposing the cartilage, also anteriorly on the left. Soft tissue remains on the posterior left. Most of the conus elasticus is removed during the operation. The entire specimen is thread-marked. A marginal sample is taken dorsally from the arytenoid region. Both specimens are sent for frozen section examination. Here the specimen is healthy, as is the marginal specimen. Thus R0 situation. Subsequent careful hemostasis. The procedure is completed when the site is free of bleeding. Removal of the Kleinsasser tube and the suprarenal swab. Removal of the mouthguard. Completion of the procedure without complications. Total cT1a glottic carcinoma on the left. ......................... specimen R0 resected. \ No newline at end of file diff --git a/184/InvasionFront_CD3_block5_x1_y11_patient184_0.json b/184/InvasionFront_CD3_block5_x1_y11_patient184_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4f57adfef31b83a825e40b2718637e19870b6afd --- /dev/null +++ b/184/InvasionFront_CD3_block5_x1_y11_patient184_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3514.2, + "Centroid Y µm": 28188.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/184/InvasionFront_CD3_block5_x2_y11_patient184_1.json b/184/InvasionFront_CD3_block5_x2_y11_patient184_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b3cd4e659a315c30db01a004862355b444d16e2 --- /dev/null +++ b/184/InvasionFront_CD3_block5_x2_y11_patient184_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6215.5, + "Centroid Y µm": 27969.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/184/InvasionFront_CD8_block5_x1_y9_patient184_0.json b/184/InvasionFront_CD8_block5_x1_y9_patient184_0.json new file mode 100644 index 0000000000000000000000000000000000000000..16a80a8dcdcef84388f154c552de22f003c8aa9d --- /dev/null +++ b/184/InvasionFront_CD8_block5_x1_y9_patient184_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3848.0, + "Centroid Y µm": 22713.0, + "Num Detections": 26896, + "Num Negative": 25286, + "Num Positive": 1610, + "Positive %": 5.986, + "Num Positive per mm^2": 677.33 + } +} \ No newline at end of file diff --git a/184/InvasionFront_CD8_block5_x2_y9_patient184_1.json b/184/InvasionFront_CD8_block5_x2_y9_patient184_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4567583403a865dc881b2d3dbb6fabbd3906e75d --- /dev/null +++ b/184/InvasionFront_CD8_block5_x2_y9_patient184_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 22713.0, + "Num Detections": 32025, + "Num Negative": 28771, + "Num Positive": 3254, + "Positive %": 10.16, + "Num Positive per mm^2": 1157.3 + } +} \ No newline at end of file diff --git a/184/TumorCenter_CD3_block5_x1_y9_patient184_0.json b/184/TumorCenter_CD3_block5_x1_y9_patient184_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c95ce20dc010bb36965e4466cc13e01ea9d47664 --- /dev/null +++ b/184/TumorCenter_CD3_block5_x1_y9_patient184_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 21763.5, + "Num Detections": 26821, + "Num Negative": 10341, + "Num Positive": 16480, + "Positive %": 61.44, + "Num Positive per mm^2": 5763.5 + } +} \ No newline at end of file diff --git a/184/TumorCenter_CD3_block5_x2_y9_patient184_1.json b/184/TumorCenter_CD3_block5_x2_y9_patient184_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2e6a3f593f1a62f730f6c369ce8e7b14bcbac08 --- /dev/null +++ b/184/TumorCenter_CD3_block5_x2_y9_patient184_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6746.4, + "Centroid Y µm": 21988.4, + "Num Detections": 22648, + "Num Negative": 14596, + "Num Positive": 8052, + "Positive %": 35.55, + "Num Positive per mm^2": 3470.9 + } +} \ No newline at end of file diff --git a/184/TumorCenter_CD8_block5_x1_y9_patient184_0.json b/184/TumorCenter_CD8_block5_x1_y9_patient184_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e1fb1ae6f9691031e2c5be4612c97b3659eb93c7 --- /dev/null +++ b/184/TumorCenter_CD8_block5_x1_y9_patient184_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3448.2, + "Centroid Y µm": 22613.0, + "Num Detections": 26328, + "Num Negative": 14903, + "Num Positive": 11425, + "Positive %": 43.39, + "Num Positive per mm^2": 4041.8 + } +} \ No newline at end of file diff --git a/184/TumorCenter_CD8_block5_x2_y9_patient184_1.json b/184/TumorCenter_CD8_block5_x2_y9_patient184_1.json new file mode 100644 index 0000000000000000000000000000000000000000..429a1ec82aa8acbc9085362a7cab7f4d0a5f01c9 --- /dev/null +++ b/184/TumorCenter_CD8_block5_x2_y9_patient184_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 22613.0, + "Num Detections": 23313, + "Num Negative": 18931, + "Num Positive": 4382, + "Positive %": 18.8, + "Num Positive per mm^2": 1965.7 + } +} \ No newline at end of file diff --git a/184/history_text.txt b/184/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e499b2e71491ee54ca0b6c1e45dcacaf3d9cdaff --- /dev/null +++ b/184/history_text.txt @@ -0,0 +1 @@ +The patient had a histologically confirmed HPV-positive cT1 cN1 oropharyngeal carcinoma on the left side. In the interdisciplinary tumor conference, surgical treatment was decided upon if the tumor was well expressible. The patient had enough time to ask questions preoperatively and was informed in detail about the procedure. The patient underwent a panendoscopy with an extensive sample biopsy on <2017>. The histology revealed a p16 positive oropharyngeal carcinoma on the left, which is why the above-mentioned procedure was indicated. Clinically, there is still a scarred and partially suspicious area in the area of the oropharynx and it cannot be guaranteed that the entire tumor was removed during the generous biopsy. Hence the indication for resection. \ No newline at end of file diff --git a/184/icd_codes.txt b/184/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/184/ops_codes.txt b/184/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..81862eacc510f6667f2a2598e2ba74df4d65b697 --- /dev/null +++ b/184/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie ohne Rekonstruktion[5-295.10 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/184/patient_clinical_data.json b/184/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..41a812d5d0c79e76f0861a4725ace1818ddcdedc --- /dev/null +++ b/184/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 50, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/184/patient_pathological_data.json b/184/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a800e7510c19d37b471792637597014bc724d33f --- /dev/null +++ b/184/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "184", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/184/surgery_description.txt b/184/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..980913b027e7822146e9f3899eccd87295156e94 --- /dev/null +++ b/184/surgery_description.txt @@ -0,0 +1 @@ +TORS (Transoral Robotic Surgery) including Neck dissection and Tracheotomy with PEG tube diff --git a/184/surgery_report.txt b/184/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..707189adc607e22fd93cd2f85f5c6204c08abf3e --- /dev/null +++ b/184/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating room. Active patient identification. Introductory consultation with anesthesia colleagues. Sterile wiping and draping of the neck area and performance of the tracheotomy by : Injection of Supra in the area of the skin incision two transverse fingers above the jugulum. Sterile wiping, draping of the patient. Start the operation with a 1.5 cm long, horizontal skin incision just below the cricoid cartilage. Cut through the cutaneous and subcutaneous tissue. Identification of the infralaryngeal musculature and lateralization of the muscles. Identification of the thyroid isthmus. Dissection above the thyroid isthmus on the cricoid. Undermining the cricoid and performing isthmus splitting. Now identification of the anterior tracheal wall and creation of a visor tracheotomy. Epithelialized tracheostomy sutures and insertion of an 8-gauge tracheostomy tube. Repositioning of the patient for insertion of the PEG tube. Slight head elevation for this. Entering the esophagus with the flexible instrument. Identification of the anterior wall of the stomach. Perform a positive diaphanoscopy. Now insertion of the PEG tube in the usual manner using the thread pull-through method without complications. Repositioning of the patient in a slight head reclination position. Then insertion of the tonsillectomy tube and re-inspection of the region. As described above, a scarred area was found. Then insertion of the DaVinci retractor and introduction of the robotic arms and the camera. The scarred area is now removed superficially in one piece using the robot. Suspicious mucosal tissue is still visible at the caudal edge, which is why a second resection is performed here. The resectate and the complete resectate are thread-marked for the frozen section. All margins free in the frozen section. Repositioning of the patient for neck dissection. Inject Supra into both sides of the neck in the course of the skin incision. Neck dissection is performed on the right side by . Skin incision, incision of the subcutaneous tissue and the platysma. Subplatysmal dissection of a platysmal flap anteriorly and posteriorly. Now identification of the anterior margin of the sternocleidomastoid. Identification of the omohyoid muscle. Dissection along the sternocleidomastoid muscle in depth. Identification of the digastric muscle and the accessorius nerve. Freeing the digastric muscle from the surrounding lymph node tissue. Identification of the submandibular gland. Sharp dissection along the internal jugular vein from caudal to cranial and mobilization of the neck preparation. This allows the carotid artery and vagus nerve to be safely protected. Safe protection of the hypoglossal nerve. Detachment of the neck preparation from cranial to caudal in the usual manner without damaging the nerve/vascular structures. Followed by wound irrigation with hydrogen and Ringer. Placement of a 10 Redon drain and two-layer wound closure using cutaneous and subcutaneous sutures. Neck dissection on the left side by : skin incision on the anterior edge of the sternocleidomastoid muscle and exposure of the sternocleidomastoid muscle of the omohyoid and digastric muscles. Visualization of the submandibular gland, visualization of the cervical vascular sheath. Level IIa shows a large metastasis that must be carefully dissected from the internal jugular vein. It can be seen that the internal jugular vein is very thin, but it can be preserved, as can the hypoglossal nerve, accessorius nerve, vagus nerve and cervical nerve. Evacuation of neck levels IIa to Va while sparing the plexus branches. Insertion of a Redon drainage and two-layer wound closure. Please present the patient to the tumor conference for planning either adjuvant radiotherapy or for controls, depending on the histology. \ No newline at end of file diff --git a/185/InvasionFront_CD3_block5_x5_y3_patient185_0.json b/185/InvasionFront_CD3_block5_x5_y3_patient185_0.json new file mode 100644 index 0000000000000000000000000000000000000000..61c324ce3a6add5156c24c413e799e4d025a81e3 --- /dev/null +++ b/185/InvasionFront_CD3_block5_x5_y3_patient185_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16491.3, + "Centroid Y µm": 7521.0, + "Num Detections": 20059, + "Num Negative": 17729, + "Num Positive": 2330, + "Positive %": 11.62, + "Num Positive per mm^2": 911.34 + } +} \ No newline at end of file diff --git a/185/InvasionFront_CD3_block5_x6_y3_patient185_1.json b/185/InvasionFront_CD3_block5_x6_y3_patient185_1.json new file mode 100644 index 0000000000000000000000000000000000000000..64c76fb0c3e3dbc0d86ccb30b6baad750cb83321 --- /dev/null +++ b/185/InvasionFront_CD3_block5_x6_y3_patient185_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 7521.0, + "Num Detections": 20267, + "Num Negative": 17588, + "Num Positive": 2679, + "Positive %": 13.22, + "Num Positive per mm^2": 1088.8 + } +} \ No newline at end of file diff --git a/185/InvasionFront_CD8_block5_x5_y3_patient185_0.json b/185/InvasionFront_CD8_block5_x5_y3_patient185_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e8d8740b46713e9f69fa22898b41902a4f3250b --- /dev/null +++ b/185/InvasionFront_CD8_block5_x5_y3_patient185_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16091.5, + "Centroid Y µm": 7421.1, + "Num Detections": 21998, + "Num Negative": 20156, + "Num Positive": 1842, + "Positive %": 8.373, + "Num Positive per mm^2": 727.11 + } +} \ No newline at end of file diff --git a/185/InvasionFront_CD8_block5_x6_y3_patient185_1.json b/185/InvasionFront_CD8_block5_x6_y3_patient185_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dc4f53841ef7d860f3821badeb809977b287f342 --- /dev/null +++ b/185/InvasionFront_CD8_block5_x6_y3_patient185_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 7321.1, + "Num Detections": 20590, + "Num Negative": 18495, + "Num Positive": 2095, + "Positive %": 10.17, + "Num Positive per mm^2": 861.1 + } +} \ No newline at end of file diff --git a/185/TumorCenter_CD3_block5_x5_y3_patient185_0.json b/185/TumorCenter_CD3_block5_x5_y3_patient185_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4cceb758dfc8c39721685136c6a6dd4b9c97e174 --- /dev/null +++ b/185/TumorCenter_CD3_block5_x5_y3_patient185_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17690.6, + "Centroid Y µm": 7970.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/185/TumorCenter_CD3_block5_x6_y3_patient185_1.json b/185/TumorCenter_CD3_block5_x6_y3_patient185_1.json new file mode 100644 index 0000000000000000000000000000000000000000..490f5429e884b084b28a6811a6f4f306c6ba91a9 --- /dev/null +++ b/185/TumorCenter_CD3_block5_x6_y3_patient185_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20489.2, + "Centroid Y µm": 8120.7, + "Num Detections": 17696, + "Num Negative": 14290, + "Num Positive": 3406, + "Positive %": 19.25, + "Num Positive per mm^2": 1393.7 + } +} \ No newline at end of file diff --git a/185/TumorCenter_CD8_block5_x5_y3_patient185_0.json b/185/TumorCenter_CD8_block5_x5_y3_patient185_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebcc0cfda7c3c1ad5c24a11e85e761a35c59cda1 --- /dev/null +++ b/185/TumorCenter_CD8_block5_x5_y3_patient185_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16366.3, + "Centroid Y µm": 7546.0, + "Num Detections": 18983, + "Num Negative": 16665, + "Num Positive": 2318, + "Positive %": 12.21, + "Num Positive per mm^2": 997.9 + } +} \ No newline at end of file diff --git a/185/TumorCenter_CD8_block5_x6_y3_patient185_1.json b/185/TumorCenter_CD8_block5_x6_y3_patient185_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6bcfb4248a1001ffd03c2159915dfe0d0898e685 --- /dev/null +++ b/185/TumorCenter_CD8_block5_x6_y3_patient185_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 7621.0, + "Num Detections": 19102, + "Num Negative": 16644, + "Num Positive": 2458, + "Positive %": 12.87, + "Num Positive per mm^2": 1001.5 + } +} \ No newline at end of file diff --git a/185/history_text.txt b/185/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b91322b6f148b292bc60e33bed2f1715944c0531 --- /dev/null +++ b/185/history_text.txt @@ -0,0 +1 @@ +Patient with cT2-3 tongue margin/oral floor carcinoma. According to clinic and imaging, mandible not infiltrated with line in the area of the tongue not crossed. \ No newline at end of file diff --git a/185/icd_codes.txt b/185/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5dcccaa1ee1f00161230c9c3d98268ccfd645662 --- /dev/null +++ b/185/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Mundboden mehrere Teilbereiche überlappend[C04.8 L] \ No newline at end of file diff --git a/185/ops_codes.txt b/185/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0942bfe43201027179a8839f3ea7ed0b7e103dd6 --- /dev/null +++ b/185/ops_codes.txt @@ -0,0 +1 @@ +Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 B] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.23 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] \ No newline at end of file diff --git a/185/patient_clinical_data.json b/185/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d6485d65912f6895e2c0b462bfcd71b61eaa066b --- /dev/null +++ b/185/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/185/patient_pathological_data.json b/185/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8606c839056068aa5e6abbdfd87044148c6f8973 --- /dev/null +++ b/185/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "185", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 9.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/185/surgery_description.txt b/185/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2e7f56cbce3a6f53c1610fd93ee4a16d0605fef0 --- /dev/null +++ b/185/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Bilateral neck dissection, Submandibulectomy on the right, Functional asymmetry on the left (Checked in July 2021), Defect coverage (Radial), PEG, Tracheotomy diff --git a/185/surgery_report.txt b/185/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..760620dfe676c60022b9bc16729744f19fafe564 --- /dev/null +++ b/185/surgery_report.txt @@ -0,0 +1 @@ +Transferring the patient to the operating theater. Carrying out the team time-out and preliminary consultation with the anesthesia colleagues. Induction of intubation anesthesia by colleagues. Start of the operation using gastroscopy. Careful pre-scanning with gastroesophagoscope into the stomach. Air insufflation and identification of the anterior wall of the stomach. Perform positive diaphanoscopy and insertion of the PEG tube in the usual manner using the thread pull-through method without complications. Now sterile wiping and draping of the patient. Then pharyngoscopy and inspection of the oral cavity again. The exophytic tumor can be seen in the area of the floor of the mouth and the edge of the tongue. Confirmation that the midline has not been crossed and bone has not been infiltrated or reached. Therefore, confirmation of the surgical indication with flap coverage. This is followed by transoral tumor resection. The tumor is macroscopically incised with a safety margin of at least 1 cm to 1.5 cm and successively removed. The floor of the mouth with external musculature and almost the entire body of the tongue on the left side are removed. The resection extends forward to the alveolar ridge, where the mucosa is pushed away directly from the bone at the level of the alveoli and left together with the periosteum on the tumor. Overall, macroscopically, the tumor is clearly removed in healthy tissue. The tumor is marked using sutures. Send in for frozen section diagnostics. All margins tumor-free in the frozen section. Therefore R0 resection. Subsequent sterile covering of all relevant surgical areas after skin disinfection. Neck dissection on both sides and tracheostoma placement. Tracheostomy: creation of the tracheostoma approx. 0.5 cm below the cricoid cartilage, separation of the cutaneous/subcutaneous tissue. Identification of the infralaryngeal musculature and division of the musculature in the midline. After visualization of the thyroid isthmus, it is dissected after bipolar coagulation. Now locate the tracheal wall and perform the tracheotomy in the 2nd to 3rd intratracheal ring space. Epithelialization of the single button sutures, reintubation to an 8-bore tracheostomy tube. Completion of the tracheostomy without complications. Neck dissection on the right side through : skin incision on the anterior edge of the sternocleidomastoid muscle. Cutting through the cutaneous/subcutaneous tissue. Separation of the platysma and subplatysmal flaps. Dissection. After identification of the anterior margin of the sternocleidomastoid muscle, dissection down to the deep cervical fascia. Now identify the digastric and omohyoid muscles and follow the musculature to the hyoid bone. Release the submandibular gland from the capsule. Snare the facial vein and loop upwards to protect the marginal facial ramus. Now expose the vascular cervical nerve sheath and successive removal of the neck preparation after exposing the accessorius nerve from cranial to caudal in the usual manner. All nerve branches of the cervical plexus, the accessorius nerve and the hypoglossal nerve are spared. Now perform the submandibulectomy. Dissection along the gland capsule for this purpose. Ligation of the V. facialis and the A. facialis. Identification of the mylohyoid muscle. Identification of the lingual nerve and sparing of the same. Removal of the wharton's duct and removal of the gland. Neck dissection also performed in the region of regions Ib and Ia without further complications. Primary wound closure using a platysma and cutaneous suture after placement of a 10-gauge Redon drain. Neck dissection on the left (): Exposure of the anterior border of the sternocleidomastoid muscle, exposure of the accessorius nerve, submandibular gland, hypoglossal nerve and digaster venter anterior and venter posterior. Expose the internal jugular vein and the branches of the cervical plexus and the common carotid artery. The neck preparation is now detached from level II to V b. Punctual hemostasis. Now turn to level I b (level I a has already been removed from the opposite side by ): here the submandibular gland is dissected from the submandibular lobe. As part of the tumor resection, the lingual nerve was removed in advance so that it could no longer be exposed. However, the hypoglossal nerve was spared. The submandibular gland is finally removed after the Wharton's duct is ligated and severed using a clamp. The facial artery can be dissected and used later for the anastomosis. Level I b is now cleared out on the left under sonographic control and to ensure that all sonographically identifiable metastases have actually been removed. This is done with major problems. The tendon of the digaster muscle is now severed in the middle and the opening to the oral cavity is bluntly made using a clamp. The opening is wide enough for 3 fingers and therefore wide enough for the pedicle of the radialis flap, which has been lifted in the meantime by . Elevation of the radial forearm flap on the left by Palpatory identification of the distal radial artery. Marking of the flap borders (11 x 7 cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Removal of split skin with the dermatome on the right thigh over the desired flap length. Application of a wound dressing after dermabrasion. Now suturing of the split skin in the area of the forearm in single button sutures. Primary wound closure of the proximal wound in the forearm area. Application of a forearm splint after application of the wound dressing. Now flap suturing (, ): The flap is pulled from cervical to enoral with the clamp and can be easily adapted to the defect using 4.0 Vicryl, as previously drawn in. There is no residual defect, the flap is well adapted on all sides. Handover to for the anastomosis of the artery. Anastomosis of the superior thyroid artery flap, venous anastomosis using 2 coupler sutures to the superior thyroid stroma. At the end, subtle hemostasis is performed using bipolar coagulation forceps. Subsequent extensive irrigation of the sides of the neck. Hemostasis. Wound closure in layers without insertion of a Redon drain on the right and 2 flaps on the left. This also included epithelialization of the tracheostoma. Subsequent completion of the procedure without complications. Patient goes to the intensive care unit for monitoring. Postoperative continuation of antibiotics with Unacid which was started intraoperatively, flap control according to the scheme for 5 days by means of clinical control and Doppler control if necessary. Feeding and PEG tube inserted for approx. 10 days, then diet build-up. Overall cT3 tongue margin/mouth floor carcinoma. cN2c status. Awaiting final histology and presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/186/InvasionFront_CD3_block22_x3_y9_patient186_0.json b/186/InvasionFront_CD3_block22_x3_y9_patient186_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6d7cfd01a38527901feb244d4564ef0133afbdf5 --- /dev/null +++ b/186/InvasionFront_CD3_block22_x3_y9_patient186_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11793.8, + "Centroid Y µm": 33915.0, + "Num Detections": 14655, + "Num Negative": 13755, + "Num Positive": 900, + "Positive %": 6.141, + "Num Positive per mm^2": 473.91 + } +} \ No newline at end of file diff --git a/186/InvasionFront_CD3_block22_x4_y9_patient186_1.json b/186/InvasionFront_CD3_block22_x4_y9_patient186_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d237eb7c3b92781c2c6f363dfe9bf2e228918145 --- /dev/null +++ b/186/InvasionFront_CD3_block22_x4_y9_patient186_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14242.5, + "Centroid Y µm": 34131.9, + "Num Detections": 18495, + "Num Negative": 15882, + "Num Positive": 2613, + "Positive %": 14.13, + "Num Positive per mm^2": 1250.8 + } +} \ No newline at end of file diff --git a/186/InvasionFront_CD8_block22_x3_y9_patient186_0.json b/186/InvasionFront_CD8_block22_x3_y9_patient186_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2fde38b62d95a929b7090bf013cf63f23cbf3b9d --- /dev/null +++ b/186/InvasionFront_CD8_block22_x3_y9_patient186_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14455.2, + "Centroid Y µm": 22256.2, + "Num Detections": 13743, + "Num Negative": 13045, + "Num Positive": 698, + "Positive %": 5.079, + "Num Positive per mm^2": 390.2 + } +} \ No newline at end of file diff --git a/186/InvasionFront_CD8_block22_x4_y9_patient186_1.json b/186/InvasionFront_CD8_block22_x4_y9_patient186_1.json new file mode 100644 index 0000000000000000000000000000000000000000..41f901bd1aa44cbac26a668229ec438407ee5918 --- /dev/null +++ b/186/InvasionFront_CD8_block22_x4_y9_patient186_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16939.7, + "Centroid Y µm": 22211.9, + "Num Detections": 16534, + "Num Negative": 13032, + "Num Positive": 3502, + "Positive %": 21.18, + "Num Positive per mm^2": 1686.1 + } +} \ No newline at end of file diff --git a/186/TumorCenter_CD3_block22_x3_y9_patient186_0.json b/186/TumorCenter_CD3_block22_x3_y9_patient186_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e89185fd9ab7fc5979c8851abc93259c60d3b2d5 --- /dev/null +++ b/186/TumorCenter_CD3_block22_x3_y9_patient186_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 23012.8, + "Num Detections": 15333, + "Num Negative": 14895, + "Num Positive": 438, + "Positive %": 2.857, + "Num Positive per mm^2": 210.21 + } +} \ No newline at end of file diff --git a/186/TumorCenter_CD3_block22_x4_y9_patient186_1.json b/186/TumorCenter_CD3_block22_x4_y9_patient186_1.json new file mode 100644 index 0000000000000000000000000000000000000000..035576507337ab2e38d123186b6ba30c76eb34eb --- /dev/null +++ b/186/TumorCenter_CD3_block22_x4_y9_patient186_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 23087.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/186/TumorCenter_CD8_block22_x3_y9_patient186_0.json b/186/TumorCenter_CD8_block22_x3_y9_patient186_0.json new file mode 100644 index 0000000000000000000000000000000000000000..312c293102bbf7c85494f3c4a91ae579384f8415 --- /dev/null +++ b/186/TumorCenter_CD8_block22_x3_y9_patient186_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13276.8, + "Centroid Y µm": 32740.7, + "Num Detections": 13976, + "Num Negative": 13367, + "Num Positive": 609, + "Positive %": 4.357, + "Num Positive per mm^2": 300.89 + } +} \ No newline at end of file diff --git a/186/TumorCenter_CD8_block22_x4_y9_patient186_1.json b/186/TumorCenter_CD8_block22_x4_y9_patient186_1.json new file mode 100644 index 0000000000000000000000000000000000000000..198c324e85bf8a3d0df807abc2113fae6a00d46d --- /dev/null +++ b/186/TumorCenter_CD8_block22_x4_y9_patient186_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16003.9, + "Centroid Y µm": 32729.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/186/history_text.txt b/186/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a04f53e8b30eaf54fa20f41c51037575ca60fb5a --- /dev/null +++ b/186/history_text.txt @@ -0,0 +1 @@ +In the patient <2015>, a cT3 transglottic laryngeal carcinoma was histologically confirmed as a moderately differentiated squamous cell carcinoma during a panendoscopy. Computed tomographic transglottic carcinoma with clear erosion of the thyroid cartilage and here cN0 neck status. Sonographic evidence of cN1 neck status with conspicuous lymph nodes in level Ib on the left side. In our interdisciplinary tumor conference, the primary surgical procedure with laryngectomy was recommended. There is a history of partial parotidectomy on the right in 1965. \ No newline at end of file diff --git a/186/icd_codes.txt b/186/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/186/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/186/ops_codes.txt b/186/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a371d6b211825740799af01bf9d5f50a8ce9dfc4 --- /dev/null +++ b/186/ops_codes.txt @@ -0,0 +1 @@ +Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/186/patient_clinical_data.json b/186/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b4cc8a779d7c30ce7e4a30e07495d91917f43893 --- /dev/null +++ b/186/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 78, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/186/patient_pathological_data.json b/186/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d59dc857e68d7c4929fa371c14f905888fdb0aec --- /dev/null +++ b/186/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "186", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 10, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/186/surgery_description.txt b/186/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a6924df187962fc0354ef32fe39fc0822764abf --- /dev/null +++ b/186/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Provox Voice Prosthesis diff --git a/186/surgery_report.txt b/186/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d933688814315d95d1f8597d036e9d78def92b3a --- /dev/null +++ b/186/surgery_report.txt @@ -0,0 +1 @@ +After bronchoscopic intubation by the anesthesia colleagues, positioning of the patient. Entry with the small bore tube under dental protection and inspection of the primary tumor region. The oral cavity and oropharynx are unremarkable. Likewise the hypopharynx with inconspicuous postcricoid region and free piriform sinus as well as free esophageal entrance. There is now a tumorous protrusion in the endolaryngeal region, especially on the right anterior side, with a barely adjustable glottic plane. In conjunction with CT imaging, confirmation of the initially described extent and indication for laryngectomy. Placement of a nasogastric feeding tube. Incision and elevation of a broad-based apron flap. This reveals extensive subcutaneous scarring on the right side, with a history of parotidectomy, which extends to the entire neck area. The neck dissection is now initially performed as a revision of the right side. Release of the markedly scarred sternocleidomastoid muscle. Exposure of the omohyoid muscle. Release of the submandibular gland and exposure of the digastric muscle, which is also scarred. A long scarred cervical vascular sheath can also be seen. Removal of the anterior neck preparation and preservation of the external carotid arteries and the hypoglossal nerve. Initial exposure of the facial vein. This is later removed for tumor resection. Exposure of the upper pole of the thyroid gland on the right side. Free preparation of the internal jugular vein with careful removal of scars. Towards the lateral neck preparation, regular tissue is visible again. Careful exposure of the cervical plexus and clearing to level Va. Significant cranial scarring again. Despite careful visualization and preparation, the accessorius nerve cannot be visualized and was presumably resected during the previous operation. Later, the upper horn of the thyroid cartilage and the hyoid are visualized. Significant scarring here as well, questionable after radiotherapy or more extensive previous surgery than can be determined from the history. Careful lateral release of the thyroid cartilage and release of the piriform sinus. Anterior exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea and lateral dissection of half of the thyroid gland. Turn to the opposite side. No preliminary treatment here. Exposure and preservation of the external vein and auricularis magnus. Exposure of the sternocleidomastoid muscle and the omohyoid muscle. Release of the submandibular gland and visualization of the digastric muscle. Release of the anterior neck preparation with careful protection of the V. facialis, A. thyroidea superior, N. hypoglossus and Ansa cervicalis. Tracing of the thyroid vessels and also dissection of the left thyroid lobe. Dissection of the left lobe of the thyroid gland. Dissection of the internal jugular vein after exposure of the accessorius nerve. After free dissection of the cervical vascular sheath, exposing the common carotid artery and the vagus nerve, completion in the direction of level V, with careful protection and preservation of the cervical plexus branches. Finally, in the case of sonographically conspicuous findings, exploration and evacuation of level Ib. To do this, release the submandibular gland. Cranial dissection of the nerve-conducting connective tissue. Careful exploration. Removal of the facial lymph nodes. Careful exploration. There are no suspicious changes here. Lymph nodes are also found dorsally and anteriorly to the gland. No further measures after final palpation. Finally, if the wound is dry, expose the thyroid cartilage horn on the left side. Finally, removal of the upper laryngeal bundle. Release of the piriform sinus and now detachment of the infrahyoid musculature. Here, the larynx appears to be coarsely widened, especially on the right side, and when the infrahyoid muscles are lifted, they are compressed and there is a questionable tumor breakthrough. It was therefore decided to leave the infrahyoid muscles completely on the laryngeal skeleton. Even if the relationship between the thyroid and hyoid is unclear, the hyoid should be removed and the soft tissue detached en bloc. Enter the pharynx in the area of the vallecula. Exposure of the epiglottis. Extension of the resection to protect the mucosa. As described above, there is no growth extending beyond the larynx in the area of the mucosal level. Careful release of the piriform sinus. Postcricoid release. Now a good overview of the tumor, which extends in the area of the larynx, especially on the right side, towards the thyroid cartilage, partly also towards the pre-epiglottic space and here, at least palpatorily, there is a suspicion of a thyroid cartilage rupture. Entry into the trachea and intubation. Removal of the first tracheal ring, creating a dorsally elevated trachea. The preparation now shows wide resection margins in relation to the mucosal level, with only a narrow area in the region of the raised infrahyoid musculature when the trachea breaks through. Therefore, an edge sample is taken at the situs, at the closest distance to the infrahyoid musculature left here. The frozen section shows this to be tumor-free, so that an R0 situation can be assumed here. A size 10 Provox prosthesis is now placed, with cranial puncture of the trachea and placement of the Provox voice prosthesis using the usual pull-through method. Finally, good positioning. Sparing right lateral myotomy in otherwise wide conditions and already visible reflux. No further measures in the area of the upper esophageal sphincter. Separation of the sternal insertions of the sternocleidomastoid muscle and subsequent careful two-layer pharyngeal closure. Careful wound inspection. If the wound is dry, insertion of a 10-gauge Redon drain. Careful two-layer wound closure with incision of the tracheostoma. Subsequent reintubation to a size 10 low-cuff cannula. Conclusion: Intraoperative R0-resected cT4a transglottic laryngeal carcinoma with right emphasis. Please continue antibiotics for 24 hours with Unacid 3 g. Perform an X-ray pre-swallow on the 8th to 10th postoperative day. Please present at our interdisciplinary tumor conference. Determination of any pre-irradiation carried out in the case of conspicuously extensive scarring on the right cervical side. \ No newline at end of file diff --git a/187/InvasionFront_CD3_block18_x1_y11_patient187_0.json b/187/InvasionFront_CD3_block18_x1_y11_patient187_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3559b870d1474ce9b3c9e88b4d7e19b587820bc7 --- /dev/null +++ b/187/InvasionFront_CD3_block18_x1_y11_patient187_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 31833.1, + "Num Detections": 25506, + "Num Negative": 18380, + "Num Positive": 7126, + "Positive %": 27.94, + "Num Positive per mm^2": 2810.8 + } +} \ No newline at end of file diff --git a/187/InvasionFront_CD3_block18_x2_y11_patient187_1.json b/187/InvasionFront_CD3_block18_x2_y11_patient187_1.json new file mode 100644 index 0000000000000000000000000000000000000000..045d978004e347760122aa14b397884604264205 --- /dev/null +++ b/187/InvasionFront_CD3_block18_x2_y11_patient187_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5921.9, + "Centroid Y µm": 32008.1, + "Num Detections": 24656, + "Num Negative": 16622, + "Num Positive": 8034, + "Positive %": 32.58, + "Num Positive per mm^2": 3166.1 + } +} \ No newline at end of file diff --git a/187/InvasionFront_CD8_block18_x1_y11_patient187_0.json b/187/InvasionFront_CD8_block18_x1_y11_patient187_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a2b5a95ab505d993f4c81e8ce2b4743874a0d7a0 --- /dev/null +++ b/187/InvasionFront_CD8_block18_x1_y11_patient187_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4147.8, + "Centroid Y µm": 34631.7, + "Num Detections": 24091, + "Num Negative": 21602, + "Num Positive": 2489, + "Positive %": 10.33, + "Num Positive per mm^2": 1010.2 + } +} \ No newline at end of file diff --git a/187/InvasionFront_CD8_block18_x2_y11_patient187_1.json b/187/InvasionFront_CD8_block18_x2_y11_patient187_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9befd28c6789d8ec74ea3f937603f7abf3eb41fe --- /dev/null +++ b/187/InvasionFront_CD8_block18_x2_y11_patient187_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 34756.6, + "Num Detections": 23118, + "Num Negative": 18450, + "Num Positive": 4668, + "Positive %": 20.19, + "Num Positive per mm^2": 1896.7 + } +} \ No newline at end of file diff --git a/187/TumorCenter_CD3_block18_x1_y11_patient187_0.json b/187/TumorCenter_CD3_block18_x1_y11_patient187_0.json new file mode 100644 index 0000000000000000000000000000000000000000..871fd9d066386a95099aaf5081b528ae93fcaa55 --- /dev/null +++ b/187/TumorCenter_CD3_block18_x1_y11_patient187_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 26486.0, + "Num Detections": 26438, + "Num Negative": 21130, + "Num Positive": 5308, + "Positive %": 20.08, + "Num Positive per mm^2": 2020.4 + } +} \ No newline at end of file diff --git a/187/TumorCenter_CD3_block18_x2_y11_patient187_1.json b/187/TumorCenter_CD3_block18_x2_y11_patient187_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ab386486f83ca21bf3941df6c8922301d632674 --- /dev/null +++ b/187/TumorCenter_CD3_block18_x2_y11_patient187_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.9, + "Centroid Y µm": 26535.9, + "Num Detections": 23429, + "Num Negative": 18700, + "Num Positive": 4729, + "Positive %": 20.18, + "Num Positive per mm^2": 1847.5 + } +} \ No newline at end of file diff --git a/187/TumorCenter_CD8_block18_x1_y11_patient187_0.json b/187/TumorCenter_CD8_block18_x1_y11_patient187_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b30be89760af0bc6bbebdc3bd5bac4ce136e2ae9 --- /dev/null +++ b/187/TumorCenter_CD8_block18_x1_y11_patient187_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3298.3, + "Centroid Y µm": 27410.5, + "Num Detections": 25715, + "Num Negative": 19480, + "Num Positive": 6235, + "Positive %": 24.25, + "Num Positive per mm^2": 2385.8 + } +} \ No newline at end of file diff --git a/187/TumorCenter_CD8_block18_x2_y11_patient187_1.json b/187/TumorCenter_CD8_block18_x2_y11_patient187_1.json new file mode 100644 index 0000000000000000000000000000000000000000..55c1cad3841591762ffa0af22a2fcd0684136e2b --- /dev/null +++ b/187/TumorCenter_CD8_block18_x2_y11_patient187_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5871.9, + "Centroid Y µm": 27485.4, + "Num Detections": 25723, + "Num Negative": 19157, + "Num Positive": 6566, + "Positive %": 25.53, + "Num Positive per mm^2": 2531.4 + } +} \ No newline at end of file diff --git a/187/history_text.txt b/187/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/187/icd_codes.txt b/187/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ae1b36a4d099ed052c43f413d065c9795d816f7 --- /dev/null +++ b/187/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Supraglottis[C32.1 B] \ No newline at end of file diff --git a/187/ops_codes.txt b/187/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d5cc360bf6ffca83afd328c88fc1a846355bd503 --- /dev/null +++ b/187/ops_codes.txt @@ -0,0 +1 @@ +Laserresektion Larynxgewebe mit Stützlaryngoskopie[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/187/patient_clinical_data.json b/187/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3504750366089873bbb2356f9027dc63896e6e41 --- /dev/null +++ b/187/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 71, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 67, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/187/patient_pathological_data.json b/187/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..22f7e4e5910717f63fa0a5197c06d539f4e957bd --- /dev/null +++ b/187/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "187", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/187/surgery_description.txt b/187/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..76516399d4f5bb37873aa8ed579838cfdd162b10 --- /dev/null +++ b/187/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/187/surgery_report.txt b/187/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f3a9769f8e2e5748f0b8805a5e439e2c9ffa0937 --- /dev/null +++ b/187/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Positioning of the patient. Insertion of a spreading laryngoscope. Positioning of the supraglottic tumor. Removal of the surgical microscope and CO2 laser. Performing transoral tumor resection with the CO2 laser. The resection margins extend from the roof of the pocket fold on the right side to the level of the pocket fold on the left side, completely eliminating the epiglottis. Removal of representative marginal samples. These are sent in for a frozen section and are found intraoperatively in such a way that the tumor border to the healthy tissue is less than 1 mm in the right side. Therefore, in the case of close in sano resection, a further resection is performed in the area of the right settling area in the area of the pocket crease as well as dorsally and also on the dorsal left side. These marginal samples are sent in again for frozen section and are still assessed intraoperatively as all tumor-free. Subtle hemostasis. Removal of the bulb. Repositioning of the patient for neck dissection on both sides: start with the neck dissection on the right side. If a lymph node metastasis has been removed, slight scarring here, therefore more difficult preparation conditions. Carry out neck dissection levels I b to V. Exposure of the cervical vascular sheath and the accessorius, vagus and hypoglossal nerves. Displacement and, at the end of the operation, re-embedding of the accessory nerve, vagus nerve and hypoglossal nerve in the sense of a neurolysis. The resection is performed while preserving all branches of the internal jugular vein and external carotid artery. In the area of the venous angle, where the metastasis had initially been removed in a first procedure, further lymph node conglomerates are visible. Enlarged lymph nodes can also be seen in levels II and III. All levels are completely removed. Subsequent subtle hemostasis. Insertion of a Redon drain. Multi-layer wound closure. Transition to the left side. Identical procedure here. Here, too, long exposure of the cervical vascular sheath. Exposure of the vagus nerve, accessorius nerve and hypoglossal nerve. Displacement and, at the end of the operation, re-embedding of the vagus nerve, accessory nerve and hypoglossal nerve in the sense of a neurolysis. Here too, the resection ranges from level I b to level V. Preservation of all vascular structures. The extent of the resection is identical to the opposite side. Subtle hemostasis. Insertion of a Redon drainage. Multi-layer wound closure. Performing the tracheotomy. Modified Kocher incision. Exposure and separation of the pretracheal musculature. Opening in the midline. Exposure of the thyroid isthmus. After this has been carefully coagulated, cut through it. Exposure of the anterior wall of the trachea. Performing the tracheotomy between the 2nd and 3rd cartilage clasp. Preparation of a Björk flap. Circular suturing of the tracheostoma and insertion of a size 8 tracheostomy tube. Further ventilation via the tracheostomy tube as the operation progresses. Insertion of the flexible endoscope into the stomach. After a positive diaphanoscopy, insertion of the PEG using the thread pull-through method. Application of a wound dressing. Repeated enoral check. If the wound is dry and the neck is thin, a pressure dressing is applied on both sides. Final consultation with the anesthetist. \ No newline at end of file diff --git a/188/InvasionFront_CD3_block5_x1_y9_patient188_0.json b/188/InvasionFront_CD3_block5_x1_y9_patient188_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7dac8df7fced53cadbf50597d79dce5ec58db5ea --- /dev/null +++ b/188/InvasionFront_CD3_block5_x1_y9_patient188_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3773.0, + "Centroid Y µm": 22887.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/188/InvasionFront_CD3_block5_x2_y9_patient188_1.json b/188/InvasionFront_CD3_block5_x2_y9_patient188_1.json new file mode 100644 index 0000000000000000000000000000000000000000..41c64b8b62ae115382cdafc36a1a9f4161537899 --- /dev/null +++ b/188/InvasionFront_CD3_block5_x2_y9_patient188_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 22937.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/188/InvasionFront_CD8_block5_x1_y7_patient188_0.json b/188/InvasionFront_CD8_block5_x1_y7_patient188_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79ebfa434fa046401bfced5729ae09e2f0229fbf --- /dev/null +++ b/188/InvasionFront_CD8_block5_x1_y7_patient188_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 17690.6, + "Num Detections": 25206, + "Num Negative": 24779, + "Num Positive": 427, + "Positive %": 1.694, + "Num Positive per mm^2": 186.2 + } +} \ No newline at end of file diff --git a/188/InvasionFront_CD8_block5_x2_y7_patient188_1.json b/188/InvasionFront_CD8_block5_x2_y7_patient188_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d49e173a63156f2d5a52620ed27fe7978076d761 --- /dev/null +++ b/188/InvasionFront_CD8_block5_x2_y7_patient188_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 17640.7, + "Num Detections": 23493, + "Num Negative": 23265, + "Num Positive": 228, + "Positive %": 0.9705, + "Num Positive per mm^2": 93.33 + } +} \ No newline at end of file diff --git a/188/TumorCenter_CD3_block5_x1_y7_patient188_0.json b/188/TumorCenter_CD3_block5_x1_y7_patient188_0.json new file mode 100644 index 0000000000000000000000000000000000000000..32c44e64c7b25a1f6f1b63c4f4f2c1330700882d --- /dev/null +++ b/188/TumorCenter_CD3_block5_x1_y7_patient188_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4447.6, + "Centroid Y µm": 16841.1, + "Num Detections": 22868, + "Num Negative": 22552, + "Num Positive": 316, + "Positive %": 1.382, + "Num Positive per mm^2": 149.54 + } +} \ No newline at end of file diff --git a/188/TumorCenter_CD3_block5_x2_y7_patient188_1.json b/188/TumorCenter_CD3_block5_x2_y7_patient188_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6146aaa7b6dc0db93b68cc5faf594b3017630f19 --- /dev/null +++ b/188/TumorCenter_CD3_block5_x2_y7_patient188_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6971.3, + "Centroid Y µm": 16941.0, + "Num Detections": 29682, + "Num Negative": 29370, + "Num Positive": 312, + "Positive %": 1.051, + "Num Positive per mm^2": 112.74 + } +} \ No newline at end of file diff --git a/188/TumorCenter_CD8_block5_x1_y7_patient188_0.json b/188/TumorCenter_CD8_block5_x1_y7_patient188_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bd770a8e872780011283876667ae403b0afdf3ea --- /dev/null +++ b/188/TumorCenter_CD8_block5_x1_y7_patient188_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 17615.7, + "Num Detections": 22742, + "Num Negative": 22611, + "Num Positive": 131, + "Positive %": 0.576, + "Num Positive per mm^2": 63.6 + } +} \ No newline at end of file diff --git a/188/TumorCenter_CD8_block5_x2_y7_patient188_1.json b/188/TumorCenter_CD8_block5_x2_y7_patient188_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e55c2fdff75914a4218fcf76bb2c82ea3a1fbdc3 --- /dev/null +++ b/188/TumorCenter_CD8_block5_x2_y7_patient188_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6171.7, + "Centroid Y µm": 17490.7, + "Num Detections": 29928, + "Num Negative": 29792, + "Num Positive": 136, + "Positive %": 0.4544, + "Num Positive per mm^2": 49.42 + } +} \ No newline at end of file diff --git a/188/history_text.txt b/188/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/188/icd_codes.txt b/188/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aae465d58af5bc6232d7a5d910349215a41c65a3 --- /dev/null +++ b/188/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/188/ops_codes.txt b/188/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d522e7ed67513a620cde4d84dcd1a2e2b26fb60 --- /dev/null +++ b/188/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie mit Rekonstruktion mit lokaler Schleimhaut[5-295.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/188/patient_clinical_data.json b/188/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c9b902d607415c5c004a741f02ca60c3fdf54080 --- /dev/null +++ b/188/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/188/patient_pathological_data.json b/188/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..98054548f03e9591203e464978820cda051a3ef1 --- /dev/null +++ b/188/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "188", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/188/surgery_description.txt b/188/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..75f9e222f6aa5deea20a086995bab733c8ac2ffc --- /dev/null +++ b/188/surgery_description.txt @@ -0,0 +1 @@ +Hypopharyngeal partial resection, Left neck dissection diff --git a/188/surgery_report.txt b/188/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9f4500e9ca76ebf425b5c5bc12c1e2d16174ef01 --- /dev/null +++ b/188/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesiologist. Inspection of the hypopharynx on the left side with the size C small bore tube. The tumor described above is unchanged in size, which predominantly extends to the lateral wall of the hypopharynx and slightly to the piriform sinus wall. Otherwise there is no tumor. The medial piriform sinus wall is certainly not affected by the tumor. Removal of all instruments. Repositioning of the patient for tumor resection. Injection of local anesthetic with adrenaline along the sternocleidomastoid muscle. Incision with cutting around a platysmal flap. Dissection of the platysma and the platysmal flap. A large lymph node conglomerate can be seen laterally and on the vein, which extends to the vein angle. This is dissected down from the vein. The cranial part shows that the vein is clearly infiltrated by the tumor, which is why the decision is made to resect the vein. Therefore, long dissection of the vagus nerve and the carotid artery. Exposure of the internal jugular vein at the base of the skull. Ligation of the internal jugular vein at the base of the skull and detachment of the vein. This also releases the large lymph node conglomerate. Subsequent removal of levels I b, II, III, IV and V. It can also be seen that the caudal part of the accessorius nerve is infiltrated by lymph node metastases as it passes through to the trapezius muscle. Resection of the nerve here as well. The nerve is preserved in the cranial part in the innervation area of the sternocleidomastoid muscle. Long-term dissection of the nerve here. Displacement and re-embedding at the end of the operation in the sense of neurolysis. Preservation of the plexus branches during dissection. Release of the larynx. Release of the pharynx. Resection of the lateral part of the thyroid cartilage. This provides a good view of the pharynx. Separation of the constrictor pharyngis. Opening of the pharynx lateral and caudal to the tumor. From here, under good visibility, cut around the tumor with a macroscopically sufficient safety margin. Remove frozen sections after assessing the specimen. These are still declared tumor-free intraoperatively. Therefore pharyngeal suture with single button sutures. Closure of the constrictor pharyngeal muscle with continuous sutures. As the pharynx could be closed with local mucosa without tension, suturing of the platysmal flap was not necessary. Repositioning of the platysmal flap. Multi-layer wound closure. Insertion of a Redon drain. Application of a pressure dressing. Final consultation with the anesthetist. Completion of the procedure. Note: PEG placement may need to be discussed with the patient. This was not possible under gastroscopic view due to the extensive previous operation on the abdomen. Further procedure after receipt of the final histopathological findings and performance of the neck dissection on the right side. Discussion of the findings in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/189/InvasionFront_CD3_block22_x1_y6_patient189_0.json b/189/InvasionFront_CD3_block22_x1_y6_patient189_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fbec50191ead7cf2a4de3a737e06c2a357ba6819 --- /dev/null +++ b/189/InvasionFront_CD3_block22_x1_y6_patient189_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4697.5, + "Centroid Y µm": 26186.1, + "Num Detections": 18394, + "Num Negative": 16524, + "Num Positive": 1870, + "Positive %": 10.17, + "Num Positive per mm^2": 835.98 + } +} \ No newline at end of file diff --git a/189/InvasionFront_CD3_block22_x2_y6_patient189_1.json b/189/InvasionFront_CD3_block22_x2_y6_patient189_1.json new file mode 100644 index 0000000000000000000000000000000000000000..540260f505b69ce8c6dece565655a390dc7928f0 --- /dev/null +++ b/189/InvasionFront_CD3_block22_x2_y6_patient189_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7321.1, + "Centroid Y µm": 26311.1, + "Num Detections": 21351, + "Num Negative": 19167, + "Num Positive": 2184, + "Positive %": 10.23, + "Num Positive per mm^2": 1088.2 + } +} \ No newline at end of file diff --git a/189/InvasionFront_CD8_block22_x1_y6_patient189_0.json b/189/InvasionFront_CD8_block22_x1_y6_patient189_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6307998c69c2b24c50390cdbe277592be8167ede --- /dev/null +++ b/189/InvasionFront_CD8_block22_x1_y6_patient189_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7196.2, + "Centroid Y µm": 15316.9, + "Num Detections": 17646, + "Num Negative": 16284, + "Num Positive": 1362, + "Positive %": 7.718, + "Num Positive per mm^2": 658.73 + } +} \ No newline at end of file diff --git a/189/InvasionFront_CD8_block22_x2_y6_patient189_1.json b/189/InvasionFront_CD8_block22_x2_y6_patient189_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0915eee45ff6505cf93e02defdf1c16367de4ab9 --- /dev/null +++ b/189/InvasionFront_CD8_block22_x2_y6_patient189_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9769.8, + "Centroid Y µm": 15067.0, + "Num Detections": 20311, + "Num Negative": 18045, + "Num Positive": 2266, + "Positive %": 11.16, + "Num Positive per mm^2": 1147.3 + } +} \ No newline at end of file diff --git a/189/TumorCenter_CD3_block22_x1_y6_patient189_0.json b/189/TumorCenter_CD3_block22_x1_y6_patient189_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b1f5aa3e66b1e7e20d49822fc3f01fd3a0d40194 --- /dev/null +++ b/189/TumorCenter_CD3_block22_x1_y6_patient189_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4397.7, + "Centroid Y µm": 15391.9, + "Num Detections": 24491, + "Num Negative": 23944, + "Num Positive": 547, + "Positive %": 2.233, + "Num Positive per mm^2": 235.81 + } +} \ No newline at end of file diff --git a/189/TumorCenter_CD3_block22_x2_y6_patient189_1.json b/189/TumorCenter_CD3_block22_x2_y6_patient189_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6a7ed8e37985ccccb4b118095da5190f2d0e5fbd --- /dev/null +++ b/189/TumorCenter_CD3_block22_x2_y6_patient189_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6946.3, + "Centroid Y µm": 15441.8, + "Num Detections": 21045, + "Num Negative": 20562, + "Num Positive": 483, + "Positive %": 2.295, + "Num Positive per mm^2": 216.23 + } +} \ No newline at end of file diff --git a/189/TumorCenter_CD8_block22_x1_y6_patient189_0.json b/189/TumorCenter_CD8_block22_x1_y6_patient189_0.json new file mode 100644 index 0000000000000000000000000000000000000000..889036d8c2fb00ce0adf2405b8ab1803a6027d4f --- /dev/null +++ b/189/TumorCenter_CD8_block22_x1_y6_patient189_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6421.6, + "Centroid Y µm": 24537.0, + "Num Detections": 22492, + "Num Negative": 18346, + "Num Positive": 4146, + "Positive %": 18.43, + "Num Positive per mm^2": 1801.9 + } +} \ No newline at end of file diff --git a/189/TumorCenter_CD8_block22_x2_y6_patient189_1.json b/189/TumorCenter_CD8_block22_x2_y6_patient189_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65bfc609a62edce328a2ee78388962e4301f14c7 --- /dev/null +++ b/189/TumorCenter_CD8_block22_x2_y6_patient189_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8995.2, + "Centroid Y µm": 24736.9, + "Num Detections": 20656, + "Num Negative": 17787, + "Num Positive": 2869, + "Positive %": 13.89, + "Num Positive per mm^2": 1258.2 + } +} \ No newline at end of file diff --git a/189/history_text.txt b/189/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..08444237c598d78518f51a951b703e368c991ddc --- /dev/null +++ b/189/history_text.txt @@ -0,0 +1 @@ +The patient has a mass in the left hypopharyngeal region with transition to the larynx. Furthermore, there is a post-operative laser resection of a carcinoma in situ of the left arytenoid region with neck dissection in 2006, which is why the above-mentioned procedure is indicated. \ No newline at end of file diff --git a/189/icd_codes.txt b/189/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..21e798830e4b470538fc9ca6c40a1bf6e6d3ae72 --- /dev/null +++ b/189/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 B] \ No newline at end of file diff --git a/189/ops_codes.txt b/189/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..18bb45a0f91921c29f50d714cf763db2130ea3a8 --- /dev/null +++ b/189/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit gestieltem Fernlappen[5-303.15 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheotomie[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Kleinflächige freie Spalthauttransplantation am Hals, Empfängerstelle[5-902.05 ] \ No newline at end of file diff --git a/189/patient_clinical_data.json b/189/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..88d34bf9f5a3109d67536227ae5b8aac722410fd --- /dev/null +++ b/189/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/189/patient_pathological_data.json b/189/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..41cbf6d200197959c99731864e1d618f52c396e9 --- /dev/null +++ b/189/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "189", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/189/surgery_description.txt b/189/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f000d11ac89253d11a43f445376eb52c4de27858 --- /dev/null +++ b/189/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Caudal pharyngectomy, Modified radical neck dissection, Permanent tracheotomy, Defect coverage, Pedicled flap (Pectoralis major) diff --git a/189/surgery_report.txt b/189/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..59eca2807a1bab44e8dd6bc726a0150cbb51216b --- /dev/null +++ b/189/surgery_report.txt @@ -0,0 +1 @@ +Initially beginning with a pharyngoscopy and laryngoscopy. An exophytic mass is seen, starting at the pharyngo-epiglottic fold, which extends to the left arytenoid, infiltrates the entrance of the left piriform sinus and extends to the opposite side in the postcricoid region. Now imaging with narrow-band imaging and confirmation that laser resection is not possible here, even after consulting the CT findings. Then enter with the flexible oesophagoscope and pre-scan into the stomach. Here, conditions were unremarkable on all sides. Now perform the PEG insertion using the thread pull-through method with good diaphanoscopy. Then sterile washing and draping. Create an apron flap in the usual manner. Start with neck dissection on the left side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle of the submandibular gland. Then clearing of the neck levels IIa to Va while sparing the plexus branches and sparing the hypoglossal nerve and the accessorius nerve. Unfortunately, the lingual artery and the superior thyroid artery must be removed. Level IV shows a high-lying thoracic duct. This is partially injured during neck level removal and chyle flow occurs. In this case, the duct with the vein opening is cut off and covered with Tachosil. This is performed by . Then turn to the opposite side and neck dissection on the right side. Exposure of the sternocleidomastoid muscle, omohyoid muscle, submandibular gland and digastric muscle. Clearing of the neck level while sparing the plexus branches of the hypoglossal nerve and accessorius nerve. The cervical vascular sheath was exposed and spared on both sides. The lingual artery can remain on the right side, but unfortunately the right superior thyroid artery must also be removed. The facial artery and ascending pharyngeal artery are still present on both sides and would theoretically still be available for a free flap transplant. Now release the hyoid bone and release the larynx by detaching the cervical vascular sheath and the thyroid gland from the larynx. Separation of the infrahyoid muscles and entry into the pharynx from the right side. Disluxation of the epiglottis and inspection of the tumor, which is as described above. Mucosal changes extend along the left hypopharyngeal side wall into the base of the tongue. Now incision of the mucosa at the edge of the epiglottis up to the postcricoid region and removal of the larynx, taking a large part of the pharynx on the left side with it. Initially, only a very narrow mucosal strip of the posterior wall of the hypopharynx remains. The esophageal opening itself is free and does not need to be resected. Marginal samples are taken. Here, extensive carcinoma in situ with partial transition to a microinvasive carcinoma can still be seen, particularly in the area of the left hypopharynx. Therefore, a resection must be performed here. Due to the resection, a complete pharyngectomy is performed in the caudal region. Extensive carcinoma in situ with partial microinvasion in the resected area. Therefore, further resection so that only a small amount of mucosa remains in the cranial and middle area of the hypopharynx and a transplant must be inserted in any case. After consultation with , the decision is made to use a pectoralis major graft. A pro vox prosthesis is not inserted, even after consultation with , as the pharyngeal reconstruction must be carried out completely with the pectoralis graft and there is no longer any mucous membrane capable of vibrating. Now lift the pectoralis major graft. To do this, measure the defect and lift and mark the graft 10 x 12 cm. A bridge is constructed in the area of the deltopectoral flap. The pectoralis major graft is lifted from the thoracic wall. Holding sutures are inserted and the graft is released, leaving the pedicle in place, and pulled upwards under the bridge. Mucosal sutures are then placed in the area of the esophageal inlet and also in the area of the base of the tongue and the cranial hypopharyngeal descending edge. The graft is then pulled in secondarily over the inserted sutures and knotted in place. The remaining parts of the remaining mucosa are connected to the graft to create a neopharynx through a tubed pectoralis major flap. A nasogastric tube was previously inserted for splinting. The stalk of the pectoralis major flap is positioned exactly on the chyle fistula so that it is also covered. Insertion of 3 redone drains in the thoracic region and one redone drain in each neck region. The patient is ventilated and admitted to the intensive care unit. Please continue postoperative antibiotics for at least 24 hours. Please provide fat-free nutrition with periamine for 3 days. Due to the size of the defect and the very large graft incision, there is a high risk of fistula, also because the pectoralis major flap is very large and has the lowest blood supply in the cranial area. If there is a risk of fistula, please open the neck and irrigate at an early stage. Otherwise, if there is no risk of fistula, take an X-ray vomit on the 12th postoperative day and carefully build up a diet. The patient must be presented to the tumor conference for planning of postoperative radiochemotherapy. \ No newline at end of file diff --git a/190/InvasionFront_CD3_block21_x1_y4_patient190_0.json b/190/InvasionFront_CD3_block21_x1_y4_patient190_0.json new file mode 100644 index 0000000000000000000000000000000000000000..acb4e3294103c210734980c61ed261e623277023 --- /dev/null +++ b/190/InvasionFront_CD3_block21_x1_y4_patient190_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 20064.4, + "Num Detections": 17783, + "Num Negative": 16610, + "Num Positive": 1173, + "Positive %": 6.596, + "Num Positive per mm^2": 613.59 + } +} \ No newline at end of file diff --git a/190/InvasionFront_CD3_block21_x2_y4_patient190_1.json b/190/InvasionFront_CD3_block21_x2_y4_patient190_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd49256d96ab93ece33df456b9b4eac18114e0bc --- /dev/null +++ b/190/InvasionFront_CD3_block21_x2_y4_patient190_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9120.2, + "Centroid Y µm": 20189.3, + "Num Detections": 17118, + "Num Negative": 16429, + "Num Positive": 689, + "Positive %": 4.025, + "Num Positive per mm^2": 377.93 + } +} \ No newline at end of file diff --git a/190/InvasionFront_CD8_block21_x1_y4_patient190_0.json b/190/InvasionFront_CD8_block21_x1_y4_patient190_0.json new file mode 100644 index 0000000000000000000000000000000000000000..868b865e48cee14c1275767c10d3c99ed74a4f41 --- /dev/null +++ b/190/InvasionFront_CD8_block21_x1_y4_patient190_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 9869.8, + "Num Detections": 18017, + "Num Negative": 16840, + "Num Positive": 1177, + "Positive %": 6.533, + "Num Positive per mm^2": 600.65 + } +} \ No newline at end of file diff --git a/190/InvasionFront_CD8_block21_x2_y4_patient190_1.json b/190/InvasionFront_CD8_block21_x2_y4_patient190_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3eee6ab947d880e0e83cd10891ba664585a84a6 --- /dev/null +++ b/190/InvasionFront_CD8_block21_x2_y4_patient190_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 9844.8, + "Num Detections": 16615, + "Num Negative": 16145, + "Num Positive": 470, + "Positive %": 2.829, + "Num Positive per mm^2": 256.67 + } +} \ No newline at end of file diff --git a/190/TumorCenter_CD3_block21_x1_y4_patient190_0.json b/190/TumorCenter_CD3_block21_x1_y4_patient190_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e3e1b2c21866d249a8abab1caa1fdad20f532518 --- /dev/null +++ b/190/TumorCenter_CD3_block21_x1_y4_patient190_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3123.3, + "Centroid Y µm": 13243.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/190/TumorCenter_CD3_block21_x2_y4_patient190_1.json b/190/TumorCenter_CD3_block21_x2_y4_patient190_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3dc06e4b267790f7afe12fd73d818eac747b440a --- /dev/null +++ b/190/TumorCenter_CD3_block21_x2_y4_patient190_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5497.1, + "Centroid Y µm": 12793.2, + "Num Detections": 12812, + "Num Negative": 12083, + "Num Positive": 729, + "Positive %": 5.69, + "Num Positive per mm^2": 477.11 + } +} \ No newline at end of file diff --git a/190/TumorCenter_CD8_block21_x1_y4_patient190_0.json b/190/TumorCenter_CD8_block21_x1_y4_patient190_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6cbf2fedd53709c3cb6a69fa3d368b83bd659f20 --- /dev/null +++ b/190/TumorCenter_CD8_block21_x1_y4_patient190_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 24587.0, + "Num Detections": 11123, + "Num Negative": 10021, + "Num Positive": 1102, + "Positive %": 9.907, + "Num Positive per mm^2": 812.89 + } +} \ No newline at end of file diff --git a/190/TumorCenter_CD8_block21_x2_y4_patient190_1.json b/190/TumorCenter_CD8_block21_x2_y4_patient190_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aac5a0f1ca7f411d8b8a51fd1f439b91e0c3baaf --- /dev/null +++ b/190/TumorCenter_CD8_block21_x2_y4_patient190_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8595.4, + "Centroid Y µm": 24686.9, + "Num Detections": 4997, + "Num Negative": 4683, + "Num Positive": 314, + "Positive %": 6.284, + "Num Positive per mm^2": 474.38 + } +} \ No newline at end of file diff --git a/190/history_text.txt b/190/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9765de42c73aa08d5b931e14389f1ed1e832ffe9 --- /dev/null +++ b/190/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed laryngeal carcinoma glottis and supraglottis on the right. Resection from the outside was suggested during the pre-panendoscopy and the patient was informed and informed accordingly. The above-mentioned operation was therefore indicated. \ No newline at end of file diff --git a/190/icd_codes.txt b/190/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/190/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/190/ops_codes.txt b/190/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22c36876f22a27b2756fc42ecf7a8fdacb490e08 --- /dev/null +++ b/190/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Teilresektion des Larynx nach Leroux-Robert[5-302.7 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/190/patient_clinical_data.json b/190/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d4e920ba6d9f14b852e33d1d7c651dac69687119 --- /dev/null +++ b/190/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/190/patient_pathological_data.json b/190/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9d0e84edd52d003ebfc293fe3e8fbbe5ec8b72fa --- /dev/null +++ b/190/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "190", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/190/surgery_description.txt b/190/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..905469a4ada5241be8e749fcc1b42b3faa65b237 --- /dev/null +++ b/190/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral partial laryngeal resection, Tracheoscopy, and MLE diff --git a/190/surgery_report.txt b/190/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef7250b632d07b181690f3f7217e093ceb80782e --- /dev/null +++ b/190/surgery_report.txt @@ -0,0 +1 @@ +First, tracheoscopy and MLE again: The exophytic tumor is visible, which extends from the arytenoid region on the right to the front over the anterior commissure. Supraglottic anterior right and left tumor also glottis left. Tumor also extends slightly onto the subglottis on the right. Now superimposition of partial laryngectomy according to Leroux-Robert and tracheotomy: skin disinfection, injection of a total of 10 ml Ultracaine 1% with adrenaline. Then Z-shaped skin incision running caudally into tracheotomy incision. Dissection of the subcutaneous tissue. Exposure of infrahyoid musculature. Splitting of these and dissection to the side. Exposure of the larynx. Incision in the area of the perichondrium on the left and dissection of the perichondrium from the left via the anterior commissure to the opposite side. The epiglottis is opened cranially and medially with the laryngeal hook. A triangle is cut out caudally. Enter the larynx from the left. The tumor extending to the left is revealed. Successive resection of the tumor with a safety margin of 3-4 mm on all sides. The anterior third of the left vocal fold and also the left pocket fold are removed. Resection extends to the opposite side including the cartilage triangle. As on the left side, the perichondrium is also removed here. As on the opposite side, there is no infiltration. The anterior supraglottic region on the right and the entire glottis on the left with adjacent soft tissue up to the cartilage are removed with clear deep infiltration of the tumor. The resection extends posteriorly to the arytenoid cartilage, which is partially removed, leaving the posterior upper part intact. The tumor specimen is then marked basally on the right side and sent in as a basal margin section. Marginal sample of the interary region on the right. Additional marginal specimens from the right subglottic arytenoid region and the right caudal supraglottic and right cranial regions, whereby the anterior region is also included. Marginal sample from subglottic and marginal sample from the glottis and supraglottis region on the left. All marginal samples are healthy, as is the basal area on the right. Thus an overall R0 situation. This is followed by careful hemostasis with bipolar and supratubers. Due to the extent of the tumor and the lack of clarity with the tube in place, a tracheotomy was performed during the resection. This involved exposing the thyroid isthmus, passing under it and clamping it, cutting it and treating it with a puncture ligature. Then expose the trachea. Entering the 2nd/3rd interspace. Caudal reintubation and epithelialization of the tracheostoma. In the further course after R0 resection and closure of the larynx. Drill holes are made in the cranial area for this purpose. A drill hole is made on the left This fixes the left vocal fold at the front using a 4/0 Vicryl suture. The larynx is then adapted anteriorly using a 3/0 Vicryl suture. The preserved perichondrium is moved back from the right to the left and fixed here with 4/0 Vicryl single button sutures so that complete closure is also achieved in the area of the conic ligament. The infrahyoid musculature is closed over this using 3/0 Vicryl single button sutures. The wound is then closed in layers with epithelialization of the remaining tracheostoma. Subcutaneous suture with 3/0 Vicryl and skin suture with 4/0 Ethilon single-button sutures. Finally, reintubation and insertion of an 8 mm tracheostomy tube. The cannula can be removed if the swallowing function is adequate; early reclosure of the tracheostoma can then be attempted. \ No newline at end of file diff --git a/191/InvasionFront_CD3_block1_x3_y11_patient191_0.json b/191/InvasionFront_CD3_block1_x3_y11_patient191_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6a2439006bd4ff73b0b5d2024e9743921d28c775 --- /dev/null +++ b/191/InvasionFront_CD3_block1_x3_y11_patient191_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10844.3, + "Centroid Y µm": 29209.5, + "Num Detections": 24874, + "Num Negative": 21370, + "Num Positive": 3504, + "Positive %": 14.09, + "Num Positive per mm^2": 1399.3 + } +} \ No newline at end of file diff --git a/191/InvasionFront_CD3_block1_x4_y11_patient191_1.json b/191/InvasionFront_CD3_block1_x4_y11_patient191_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c867fbe7ffb693fcc2dea3870a4adb1de7a8cb6 --- /dev/null +++ b/191/InvasionFront_CD3_block1_x4_y11_patient191_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 29334.5, + "Num Detections": 29574, + "Num Negative": 25830, + "Num Positive": 3744, + "Positive %": 12.66, + "Num Positive per mm^2": 1421.2 + } +} \ No newline at end of file diff --git a/191/InvasionFront_CD8_block1_x3_y11_patient191_0.json b/191/InvasionFront_CD8_block1_x3_y11_patient191_0.json new file mode 100644 index 0000000000000000000000000000000000000000..996bf898d74be183c24f8c066fd2217c0b8ee758 --- /dev/null +++ b/191/InvasionFront_CD8_block1_x3_y11_patient191_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 27660.4, + "Num Detections": 24032, + "Num Negative": 20118, + "Num Positive": 3914, + "Positive %": 16.29, + "Num Positive per mm^2": 1571.6 + } +} \ No newline at end of file diff --git a/191/InvasionFront_CD8_block1_x4_y11_patient191_1.json b/191/InvasionFront_CD8_block1_x4_y11_patient191_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9ed7964b311e566ed89c87a4a617dc83e6470360 --- /dev/null +++ b/191/InvasionFront_CD8_block1_x4_y11_patient191_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 27735.3, + "Num Detections": 26575, + "Num Negative": 20075, + "Num Positive": 6500, + "Positive %": 24.46, + "Num Positive per mm^2": 2589.6 + } +} \ No newline at end of file diff --git a/191/TumorCenter_CD8_block1_x3_y11_patient191_0.json b/191/TumorCenter_CD8_block1_x3_y11_patient191_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a1ebc01344d5c8fe7af3cc98a16dcac4871ae522 --- /dev/null +++ b/191/TumorCenter_CD8_block1_x3_y11_patient191_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 36330.8, + "Num Detections": 29877, + "Num Negative": 25492, + "Num Positive": 4385, + "Positive %": 14.68, + "Num Positive per mm^2": 1644.7 + } +} \ No newline at end of file diff --git a/191/TumorCenter_CD8_block1_x4_y11_patient191_1.json b/191/TumorCenter_CD8_block1_x4_y11_patient191_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3a7c4d42e3f45ce5834b6bf3186c38ca7d2c07b --- /dev/null +++ b/191/TumorCenter_CD8_block1_x4_y11_patient191_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 36280.8, + "Num Detections": 21707, + "Num Negative": 19460, + "Num Positive": 2247, + "Positive %": 10.35, + "Num Positive per mm^2": 1103.6 + } +} \ No newline at end of file diff --git a/191/history_text.txt b/191/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8182ef5fe91148a77cc38d827e5902184a9c3b03 --- /dev/null +++ b/191/history_text.txt @@ -0,0 +1 @@ +The patient <2017> had a left neck mass at level II. Sonography revealed a fluid-filled cystic mass with suspicious sonomorphology. Therefore, <2017> an unremarkable panendoscopy and a lymph node extirpation in level II on the left was performed. Histologically, this revealed a p16 positive lymph node metastasis of a squamous cell carcinoma, and the subsequent PET-CT showed a suspicious accumulation of contrast medium in the area of the left tonsil. Therefore indication for the above-mentioned procedure. The patient had ample opportunity to ask questions about this before the operation. \ No newline at end of file diff --git a/191/icd_codes.txt b/191/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..35557d7f7f6eb177095dfb36d94e3b46ab4c8d6f --- /dev/null +++ b/191/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Gaumenbogentonsillen[C09.1 L] Lymphknotenvergrößerung, umschrieben[R59.0 ] \ No newline at end of file diff --git a/191/ops_codes.txt b/191/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ea454548911e732c72bb5ce1dd44d604af622822 --- /dev/null +++ b/191/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] \ No newline at end of file diff --git a/191/patient_clinical_data.json b/191/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9a76b199366085c244227d50ff331dc081c4ed1e --- /dev/null +++ b/191/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 46, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/191/patient_pathological_data.json b/191/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4a549aac2af94fccb428d20e1054cd0d5100a966 --- /dev/null +++ b/191/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "191", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/191/surgery_description.txt b/191/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..50312bf02ac9be42bdb574ea1e368d8a571c1efe --- /dev/null +++ b/191/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection diff --git a/191/surgery_report.txt b/191/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..6bde13b483358f58be730d21a280efb1519465de --- /dev/null +++ b/191/surgery_report.txt @@ -0,0 +1 @@ +Initial head positioning by the surgeon. Insertion of the McIVOR oral spatula and adjustment of the left tonsil tube. Macroscopically inconspicuous .............. Tonsil, in particular no evidence of growth of the suspected carcinoma beyond the tonsil on inspection. Marking of the resection margins in the area of the anterior and posterior palatal arch using a monopolar needle. Tumor tonsillectomy is then performed using the dissection technique, including a muscle margin of the palatoglossal arch and parts of the anterior and posterior palatal arch and the base of the tongue in the area of the lower pole. The tonsil is extirpated in toto and sent to the frozen section marked with a suture. The diagnosis of a squamous cell carcinoma resected in sano, but only just R0 towards the base of the wound. In the meantime, head repositioning for neck dissection on the left. After lymph node extirpation in level II on the left, approx. 1.5 transverse fingers wide and thus relatively far superior, a horizontal scar is seen. An attempt is initially made to integrate this into the course of the neck dissection, but this is too close to the lower jaw and would also result in a cosmetically unfavorable, very anterior course of the further incision. It was therefore decided to make a new incision in this area, far posterior to the posterior edge of the sternocleidomastoid muscle. Injection of a total of 8 ml xylocaine with added adrenaline. Skin disinfection and sterile draping. Skin incision down to the platysma. Exposure and ligation of the external jugular vein. Subsequent dissection of the sternocleidomastoid muscle and exposure and protection of the accessorius nerve. Caudal dissection and exposure of the omohyoid muscle. Superiorly, the digaster muscle is exposed through the scar tissue and dissected about halfway anteriorly. Condition after previous operation, difficult conditions. Now dissect the vascular nerve sheath. The neck dissect is dissected in one piece up to level IIa, set down cranially in level IIa, cut caudally under the accessorius nerve. The cervical anus is then located and dissected from inferior to superior and laterally, with successive clean dissection of the neck dissectate from the scalene musculature while protecting the anus. This is successful without any problems. Now caudally, at the end of level IV, separation of the neck dissectate after bipolar coagulation and ligation. Now, after anterior dissection of the outlet of the facial vein and the angle between the facial vein and the internal jugular vein. Dissection of a further lymph node and a small amount of fatty tissue. Subsequent wound irrigation and meticulous hemostasis using bipolar coagulation. There is no evidence of residual fatty tissue or lymphatic tissue in the surgical area. Therefore, insertion of a 10 Redon drain and two-layer wound closure in the typical manner. Head repositioning in the reclination position and insertion of the McIVOR oral spatula. Adjustment of the left tonsil lodge and removal of a total of five marginal samples, which are sent for frozen section. Minute hemostasis using bipolar coagulation. By , prophylactic caudal and lateral repositioning in the tonsil bed. All marginal samples were found to be tumor-free by the pathology colleagues. Thus repeated inspection. Dry conditions. Removal of the inserted ball swab. Insertion of a nasogastric feeding tube, under visualization in the typical manner. Completion of the procedure without complications. \ No newline at end of file diff --git a/192/InvasionFront_CD3_block14_x5_y5_patient192_0.json b/192/InvasionFront_CD3_block14_x5_y5_patient192_0.json new file mode 100644 index 0000000000000000000000000000000000000000..132f6bd3696cc248ed88f1c8dd00b5881b8134b1 --- /dev/null +++ b/192/InvasionFront_CD3_block14_x5_y5_patient192_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17140.9, + "Centroid Y µm": 16366.3, + "Num Detections": 20279, + "Num Negative": 20012, + "Num Positive": 267, + "Positive %": 1.317, + "Num Positive per mm^2": 112.71 + } +} \ No newline at end of file diff --git a/192/InvasionFront_CD3_block14_x6_y5_patient192_1.json b/192/InvasionFront_CD3_block14_x6_y5_patient192_1.json new file mode 100644 index 0000000000000000000000000000000000000000..456856f77752d6d16bf4ba7568cc0bfe0369559e --- /dev/null +++ b/192/InvasionFront_CD3_block14_x6_y5_patient192_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19639.6, + "Centroid Y µm": 16541.2, + "Num Detections": 16919, + "Num Negative": 16521, + "Num Positive": 398, + "Positive %": 2.352, + "Num Positive per mm^2": 182.29 + } +} \ No newline at end of file diff --git a/192/InvasionFront_CD8_block14_x5_y5_patient192_0.json b/192/InvasionFront_CD8_block14_x5_y5_patient192_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8491874ea7d3b17c62dde1448be524cc8f717552 --- /dev/null +++ b/192/InvasionFront_CD8_block14_x5_y5_patient192_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16966.0, + "Centroid Y µm": 12131.1, + "Num Detections": 18838, + "Num Negative": 18768, + "Num Positive": 70, + "Positive %": 0.3716, + "Num Positive per mm^2": 29.58 + } +} \ No newline at end of file diff --git a/192/InvasionFront_CD8_block14_x6_y5_patient192_1.json b/192/InvasionFront_CD8_block14_x6_y5_patient192_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3697a66a49f34a45e97b656092728c08fb66259 --- /dev/null +++ b/192/InvasionFront_CD8_block14_x6_y5_patient192_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19489.7, + "Centroid Y µm": 12206.0, + "Num Detections": 18532, + "Num Negative": 18400, + "Num Positive": 132, + "Positive %": 0.7123, + "Num Positive per mm^2": 57.77 + } +} \ No newline at end of file diff --git a/192/TumorCenter_CD3_block14_x5_y5_patient192_0.json b/192/TumorCenter_CD3_block14_x5_y5_patient192_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f3fc6f603b651e0f2891f8d2b4d96e91eb78282c --- /dev/null +++ b/192/TumorCenter_CD3_block14_x5_y5_patient192_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16766.1, + "Centroid Y µm": 13143.0, + "Num Detections": 17720, + "Num Negative": 17068, + "Num Positive": 652, + "Positive %": 3.679, + "Num Positive per mm^2": 292.74 + } +} \ No newline at end of file diff --git a/192/TumorCenter_CD3_block14_x6_y5_patient192_1.json b/192/TumorCenter_CD3_block14_x6_y5_patient192_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c42d23fa7e164a0c84b38b55af984f5aad5205d8 --- /dev/null +++ b/192/TumorCenter_CD3_block14_x6_y5_patient192_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19264.8, + "Centroid Y µm": 13317.9, + "Num Detections": 16550, + "Num Negative": 16289, + "Num Positive": 261, + "Positive %": 1.577, + "Num Positive per mm^2": 118.16 + } +} \ No newline at end of file diff --git a/192/TumorCenter_CD8_block14_x5_y5_patient192_0.json b/192/TumorCenter_CD8_block14_x5_y5_patient192_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ab11dea39deeecaf9d3e27101304f4e517b3fff0 --- /dev/null +++ b/192/TumorCenter_CD8_block14_x5_y5_patient192_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 13243.0, + "Num Detections": 16850, + "Num Negative": 16605, + "Num Positive": 245, + "Positive %": 1.454, + "Num Positive per mm^2": 114.6 + } +} \ No newline at end of file diff --git a/192/TumorCenter_CD8_block14_x6_y5_patient192_1.json b/192/TumorCenter_CD8_block14_x6_y5_patient192_1.json new file mode 100644 index 0000000000000000000000000000000000000000..77afcc3a5cde0fe52a3dfd64c1c90612f078437b --- /dev/null +++ b/192/TumorCenter_CD8_block14_x6_y5_patient192_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18290.3, + "Centroid Y µm": 13168.0, + "Num Detections": 17017, + "Num Negative": 16982, + "Num Positive": 35, + "Positive %": 0.2057, + "Num Positive per mm^2": 15.87 + } +} \ No newline at end of file diff --git a/192/history_text.txt b/192/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e9a9c593fdf59969164b23ded3e4fe13ed140c70 --- /dev/null +++ b/192/history_text.txt @@ -0,0 +1 @@ +The patient has an exophytic mass on the left edge of the tongue, which occupies a large part of the underside of the tongue on the left side and extends from here to the posterior third of the tongue to the base of the tongue at a distance of about 1 cm. The tumor does not appear to cross the midline of the tongue. The surface of the tongue is also only covered by the tumor in the area of the edge of the tongue. \ No newline at end of file diff --git a/192/icd_codes.txt b/192/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3d48c63d6be7d0c43d08b0de374d51480a8456a8 --- /dev/null +++ b/192/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes und der Zungenspitze[C02.1 ] \ No newline at end of file diff --git a/192/ops_codes.txt b/192/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ca1dc154cfd97697469d20a5e86a79d46848bfba --- /dev/null +++ b/192/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/192/patient_clinical_data.json b/192/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c1411619a3aa0292bfd2c2e475f0e59f31744c8b --- /dev/null +++ b/192/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 45, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/192/patient_pathological_data.json b/192/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a482041627f2be74387b27b9679e0dd311f4e157 --- /dev/null +++ b/192/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "192", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 14, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/192/surgery_description.txt b/192/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5f7e4dbdf6b2f783c52354bcc8c26bb5bf260994 --- /dev/null +++ b/192/surgery_description.txt @@ -0,0 +1 @@ +Removal of tongue margin tumor, Tracheotomy diff --git a/192/surgery_report.txt b/192/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e351350e7f66f5c26a1fea64c644b24f7a8bf74e --- /dev/null +++ b/192/surgery_report.txt @@ -0,0 +1 @@ +After insertion of the oral retractor, marking of the resection margins with monopolar coagulation. The tumor reaches very close to the alveolar ridge on the left side and anteriorly. The tumor is then removed from the tongue using monopolar coagulation and sharp dissection alternately. Careful ligation of all larger vessels. The medial and dorsal parts of the tumor can be safely removed in sano. In the sublingual lateral deposition area, the tumor extends close to the deposition margin. The suture marking of the specimen is performed here. Subsequently, a resection is performed and representative marginal samples are taken from the anterior and lateral sublingual deposition area. A slightly hardened palpable structure in the dorsal left lateral settling area at the base of the wound is also resected. Then careful hemostasis again. Then consult and discuss the need for a tracheostomy. If the wound defect is extremely large and the wound area extends to the base of the tongue, a decision is made on the need for a tracheostomy given the swelling to be expected here. The patient is therefore repositioned. Injection of local anesthetic with adrenaline and skin disinfection. Then pretracheal skin incision and layered preparation in depth. Then expose the thyroid isthmus. After clamping it off, it is cut off on both sides. The anterior surface of the trachea is then exposed. Then ......... of the trachea between the 2nd and 3rd cricoid cartilage. Creation of the Björk flap. Then epithelialization of the tracheostoma. If the wound is dry, insert a size 8 tracheostomy tube, which should remain in place until the 4th or 5th postoperative day if possible. Now re-inspect the enoral wound surface. However, after removal of the endonasal tube on the left side, a slight bleeding of the mucous membrane can be seen, which is diffuse on closer inspection. It was therefore decided to insert a merocele tamponade into the lower nasal passage. If possible, this can be removed on the 1st postoperative day. Further procedure: A level I neck dissection should now be planned for the patient on both sides. In addition, if there is a pronounced defect in the edge of the tongue, defect coverage using a radial flap should also be planned. The surgery date already scheduled for <2010> may have to be brought forward. The patient is admitted to the intensive care unit for monitoring. \ No newline at end of file diff --git a/193/InvasionFront_CD3_block11_x5_y12_patient193_0.json b/193/InvasionFront_CD3_block11_x5_y12_patient193_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ef04d9ef4af67225a99d9e8a383cd66d032ff03 --- /dev/null +++ b/193/InvasionFront_CD3_block11_x5_y12_patient193_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 28534.9, + "Num Detections": 18798, + "Num Negative": 18761, + "Num Positive": 37, + "Positive %": 0.1968, + "Num Positive per mm^2": 18.76 + } +} \ No newline at end of file diff --git a/193/InvasionFront_CD3_block11_x6_y12_patient193_1.json b/193/InvasionFront_CD3_block11_x6_y12_patient193_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1167b0223052e38083c147ed0b9887b46e1561f1 --- /dev/null +++ b/193/InvasionFront_CD3_block11_x6_y12_patient193_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 28434.9, + "Num Detections": 19114, + "Num Negative": 19045, + "Num Positive": 69, + "Positive %": 0.361, + "Num Positive per mm^2": 33.74 + } +} \ No newline at end of file diff --git a/193/InvasionFront_CD8_block11_x5_y12_patient193_0.json b/193/InvasionFront_CD8_block11_x5_y12_patient193_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c68e7e17a45d7a4af33173b85261c9c274970c65 --- /dev/null +++ b/193/InvasionFront_CD8_block11_x5_y12_patient193_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18620.3, + "Centroid Y µm": 40118.7, + "Num Detections": 16897, + "Num Negative": 16884, + "Num Positive": 13, + "Positive %": 0.0769, + "Num Positive per mm^2": 7.263 + } +} \ No newline at end of file diff --git a/193/InvasionFront_CD8_block11_x6_y12_patient193_1.json b/193/InvasionFront_CD8_block11_x6_y12_patient193_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c8e986ec38a87a604070205d0afb73b4013bc67a --- /dev/null +++ b/193/InvasionFront_CD8_block11_x6_y12_patient193_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21151.2, + "Centroid Y µm": 39927.1, + "Num Detections": 13219, + "Num Negative": 13194, + "Num Positive": 25, + "Positive %": 0.1891, + "Num Positive per mm^2": 15.69 + } +} \ No newline at end of file diff --git a/193/TumorCenter_CD3_block11_x5_y12_patient193_0.json b/193/TumorCenter_CD3_block11_x5_y12_patient193_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f8e9c00f36f1909e6a147b08793f85a2d97aa675 --- /dev/null +++ b/193/TumorCenter_CD3_block11_x5_y12_patient193_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 30034.1, + "Num Detections": 13906, + "Num Negative": 13822, + "Num Positive": 84, + "Positive %": 0.6041, + "Num Positive per mm^2": 51.75 + } +} \ No newline at end of file diff --git a/193/TumorCenter_CD3_block11_x6_y12_patient193_1.json b/193/TumorCenter_CD3_block11_x6_y12_patient193_1.json new file mode 100644 index 0000000000000000000000000000000000000000..09bedc5799c3c52f6905e404fe321dd50a622193 --- /dev/null +++ b/193/TumorCenter_CD3_block11_x6_y12_patient193_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20664.1, + "Centroid Y µm": 30134.0, + "Num Detections": 23004, + "Num Negative": 22928, + "Num Positive": 76, + "Positive %": 0.3304, + "Num Positive per mm^2": 32.27 + } +} \ No newline at end of file diff --git a/193/TumorCenter_CD8_block11_x5_y12_patient193_0.json b/193/TumorCenter_CD8_block11_x5_y12_patient193_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fbc542486887c57a7c47185629929f2c495b04bd --- /dev/null +++ b/193/TumorCenter_CD8_block11_x5_y12_patient193_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 29759.2, + "Num Detections": 15982, + "Num Negative": 15925, + "Num Positive": 57, + "Positive %": 0.3567, + "Num Positive per mm^2": 28.63 + } +} \ No newline at end of file diff --git a/193/TumorCenter_CD8_block11_x6_y12_patient193_1.json b/193/TumorCenter_CD8_block11_x6_y12_patient193_1.json new file mode 100644 index 0000000000000000000000000000000000000000..739e14be0f120308cf97b0c14559bc5b29b7bb48 --- /dev/null +++ b/193/TumorCenter_CD8_block11_x6_y12_patient193_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 29859.2, + "Num Detections": 19349, + "Num Negative": 19321, + "Num Positive": 28, + "Positive %": 0.1447, + "Num Positive per mm^2": 11.72 + } +} \ No newline at end of file diff --git a/193/history_text.txt b/193/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..60e3b9113c32c17a2cfaa34235a939e45726414d --- /dev/null +++ b/193/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oropharyngeal carcinoma on the left, infiltration of the tonsil lobe and beginning at the base of the tongue. The above-mentioned surgery was therefore indicated. Following partial laryngectomy several times and residual laryngectomy with pectoralis major flap and deltopectoral flap. \ No newline at end of file diff --git a/193/icd_codes.txt b/193/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/193/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/193/ops_codes.txt b/193/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6fdfd3dc2f92f6584217043519d137f9a906d70 --- /dev/null +++ b/193/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Ohne Rekonstruktion[5-295.00 ] \ No newline at end of file diff --git a/193/patient_clinical_data.json b/193/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7c89bb34185d8f232a99f3568cc6f68007acdcda --- /dev/null +++ b/193/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/193/patient_pathological_data.json b/193/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d765d99218391c760797815d1a36b3352642d45a --- /dev/null +++ b/193/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "193", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/193/surgery_description.txt b/193/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..75c188dcf9146da48f00a189f85bf1ebf02add35 --- /dev/null +++ b/193/surgery_description.txt @@ -0,0 +1 @@ +Resection of tonsillar carcinoma diff --git a/193/surgery_report.txt b/193/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..41c4f8e01b13303c88e537ead22c5cd341afc9ab --- /dev/null +++ b/193/surgery_report.txt @@ -0,0 +1 @@ +First, placement of a tongue tie suture. The McIvor spatula is then applied, which is considerably more difficult with restricted mouth opening. Finally, the described tumor is palpated in the area of the tonsil lobe, oropharyngeal side wall, extending into the base of the tongue. With alternate insertion of the tonsil retractor and mouth retractor, the tumor is resected with a distance of at least 1 to 1.5 cm, macroscopically on all sides in healthy tissue. The entire tonsil lobe, anterior and posterior palatal arch, larger parts of the pharyngeal wall on the left, glossoalveolar groove and base of the tongue are resected, with an extension of approx. 30-40%. The resection extends caudally to the hypopharyngeal entrance. The specimen was removed in its entirety. Suture marking. In addition, a marginal sample was taken in the area of the tongue body transition to the base of the tongue, extending down to the caudal side. This is also thread-marked for frozen section examination. In the frozen section, tumor specimen and marginal sample in healthy tissue. Thus R0 situation. This is followed by careful hemostasis. Final inspection. No more bleeding. Completion of the procedure without complications. \ No newline at end of file diff --git a/194/InvasionFront_CD3_block9_x3_y6_patient194_0.json b/194/InvasionFront_CD3_block9_x3_y6_patient194_0.json new file mode 100644 index 0000000000000000000000000000000000000000..825ef170f2e588811a89b59a0f6157b5fe20f0fe --- /dev/null +++ b/194/InvasionFront_CD3_block9_x3_y6_patient194_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12643.3, + "Centroid Y µm": 15641.7, + "Num Detections": 20405, + "Num Negative": 19473, + "Num Positive": 932, + "Positive %": 4.568, + "Num Positive per mm^2": 385.41 + } +} \ No newline at end of file diff --git a/194/InvasionFront_CD3_block9_x4_y6_patient194_1.json b/194/InvasionFront_CD3_block9_x4_y6_patient194_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7675a97e7c5e314f5786831c8d2692a01e03959a --- /dev/null +++ b/194/InvasionFront_CD3_block9_x4_y6_patient194_1.json @@ -0,0 +1,11 @@ +{ + 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