diff --git a/642/icd_codes.txt b/642/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0b3cbae91d0de18b52f016f4fb0eb0aee9e11c88 --- /dev/null +++ b/642/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] \ No newline at end of file diff --git a/642/surgery_description.txt b/642/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0c16962c5dadca5cb88e43731c591478ce65aeac --- /dev/null +++ b/642/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/642/surgery_report.txt b/642/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3db95e926d1f51233f9a834f1a29772bb18dcd88 --- /dev/null +++ b/642/surgery_report.txt @@ -0,0 +1 @@ +First insertion with the small water tube and inspection of the tumor region. Then insertion of the tonsil plug. It is noticed that there is a suspicious lesion on the posterior pharyngeal wall relatively far cranially in the oropharynx; this is biopsied and sent for a frozen section. This also shows squamous cell carcinoma, which was not previously described. This area is connected submucosally with 2 further suspicious areas that were previously described, 1x in the hypopharynx at the entrance to the piriform sinus and 1x at the transition between the oropharynx and hypopharynx. All these lesions are connected submucosally. Then sterile washing and draping and start with transoral tumor resection. Cut around the tumor with the monopolar needle. Lift off the prevertebral fascia and dissect as far caudally as possible. If the overview is restricted, switch to a transcervical approach. For this purpose, create an apron flap in the usual manner. Expose the cervical vascular sheath. Securing the cervical sheath. Exposure of the left part of the hyoid bone and the superior laryngeal nerve. Expose the pharyngeal muscles and then enter with the small bore tube and determine the site where the pharyngotomy will be performed. It can be seen that the tumor is at the entrance to the piriform sinus and is therefore also partially under the thyroid cartilage. Exposure of the upper horn of the thyroid cartilage and detachment of the piriform sinus from the thyroid cartilage on this side. The upper horn of the thyroid cartilage and a small part of the thyroid cartilage must be resected in order to reach the tumor properly. Then enter the pharynx and resect the tumor with a safety margin of 0.5 to 1 cm. The specimen is placed en bloc on cork and marked for histology. All margins free in the frozen section, i.e. intraoperative R0 situation on the specimen. Measure the defect 12 x 6 cm and mark on the forearm. Start preparation of the radialis graft by and . Exposure of the cephalic vein. Exposure of the brachiocephalic muscle. Showing the venous star in the crook of the elbow. Visualization of the venous confluence. Visualization of the radial superficial ramus nerve. Exposure of the radial artery. Removal of the radial artery. Lifting of the radialis graft from the tendons. Then dissection of the pedicle up to the crook of the elbow. Removal of the pedicle, including 2 deep veins and 1 superficial large cephalic vein. In the meantime, parallel neck dissection on the right side by and . After creation of the apron flap by , perform a neck dissection on the right side Level II to V. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the accessorius nerve. Exposure of the omohyoid muscle. Tracing the omohyoid to the hyoid bone. Visualization of the cervical vascular sheath of the internal jugular vein. Exposure of the submandibular gland and the posterior venter of the digaster. The borders are thus shown. Now detach the neck preparation from level II b, II, III, IV and V, preserving all non-lymphatic structures. The vagus nerve and carotid artery are exposed and spared. The accessor nerve is exposed and also spared. The plexus branches are clearly visible in depth and level V is cleared. No evidence of chyle fistula. Left Start of neck dissection by and takeover of . Exposure of the cervical vascular sheath after the borders, i.e. sternocleidomastoid, omohyoid, submandibular and accessory gland and digastric muscle, have been exposed. Neck levels II to V were then removed. Plexus branches were spared, hypoglossus spared and accessorius nerve spared, cervical nerve spared. Then suturing of the radialis graft, first from the transoral, then from the transcervical side and removal of the pedicle to the left side. End-to-side anastomosis between the cephalic vein and internal jugular vein and coupler between the facial vein and a deep vein of the radialis graft and anastomosis between the radial artery and facial artery. Insertion of Redon drains, one on each side, and two-layer wound closure. Flap control according to the usual scheme, antibiotics for at least 24 hours. \ No newline at end of file diff --git a/643/InvasionFront_CD3_block15_x6_y8_patient643_1.json b/643/InvasionFront_CD3_block15_x6_y8_patient643_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c930e32a2e985e8167f44df30ebf65404442aa9b --- /dev/null +++ b/643/InvasionFront_CD3_block15_x6_y8_patient643_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21263.7, + "Centroid Y µm": 29609.3, + "Num Detections": 19497, + "Num Negative": 18072, + "Num Positive": 1425, + "Positive %": 7.309, + "Num Positive per mm^2": 584.08 + } +} \ No newline at end of file diff --git a/643/InvasionFront_CD8_block15_x5_y8_patient643_0.json b/643/InvasionFront_CD8_block15_x5_y8_patient643_0.json new file mode 100644 index 0000000000000000000000000000000000000000..79eaf3aa0a277cb4439afbbf2cc940b20d0b241b --- /dev/null +++ b/643/InvasionFront_CD8_block15_x5_y8_patient643_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16554.0, + "Centroid Y µm": 19646.6, + "Num Detections": 19555, + "Num Negative": 18993, + "Num Positive": 562, + "Positive %": 2.874, + "Num Positive per mm^2": 223.97 + } +} \ No newline at end of file diff --git a/643/InvasionFront_CD8_block15_x6_y8_patient643_1.json b/643/InvasionFront_CD8_block15_x6_y8_patient643_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd5e9e6cdf58ec6d86d53a881dadf8c808bb55a4 --- /dev/null +++ b/643/InvasionFront_CD8_block15_x6_y8_patient643_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19032.2, + "Centroid Y µm": 19471.1, + "Num Detections": 17537, + "Num Negative": 17288, + "Num Positive": 249, + "Positive %": 1.42, + "Num Positive per mm^2": 103.86 + } +} \ No newline at end of file diff --git a/643/TumorCenter_CD3_block15_x5_y8_patient643_0.json b/643/TumorCenter_CD3_block15_x5_y8_patient643_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a1749a1cdda0d198de280b95e8d2d6a4c8dcbc43 --- /dev/null +++ b/643/TumorCenter_CD3_block15_x5_y8_patient643_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 23487.6, + "Num Detections": 20389, + "Num Negative": 19693, + "Num Positive": 696, + "Positive %": 3.414, + "Num Positive per mm^2": 272.2 + } +} \ No newline at end of file diff --git a/643/TumorCenter_CD3_block15_x6_y8_patient643_1.json b/643/TumorCenter_CD3_block15_x6_y8_patient643_1.json new file mode 100644 index 0000000000000000000000000000000000000000..16b04e4cfad2582f79f6946ae54cea0555822b37 --- /dev/null +++ b/643/TumorCenter_CD3_block15_x6_y8_patient643_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 23612.5, + "Num Detections": 16845, + "Num Negative": 16303, + "Num Positive": 542, + "Positive %": 3.218, + "Num Positive per mm^2": 257.6 + } +} \ No newline at end of file diff --git a/643/TumorCenter_CD8_block15_x5_y8_patient643_0.json b/643/TumorCenter_CD8_block15_x5_y8_patient643_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b7a3f2d887b5b77797bb960801e6cb3425f939c1 --- /dev/null +++ b/643/TumorCenter_CD8_block15_x5_y8_patient643_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 19964.4, + "Num Detections": 19592, + "Num Negative": 19181, + "Num Positive": 411, + "Positive %": 2.098, + "Num Positive per mm^2": 164.43 + } +} \ No newline at end of file diff --git a/643/TumorCenter_CD8_block15_x6_y8_patient643_1.json b/643/TumorCenter_CD8_block15_x6_y8_patient643_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d069055e70e35b997e5f328b0fa5f3e8916c783b --- /dev/null +++ b/643/TumorCenter_CD8_block15_x6_y8_patient643_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21388.7, + "Centroid Y µm": 20039.4, + "Num Detections": 18307, + "Num Negative": 18042, + "Num Positive": 265, + "Positive %": 1.448, + "Num Positive per mm^2": 110.4 + } +} \ No newline at end of file diff --git a/643/history_text.txt b/643/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..60e95c136b6ba9b06ce152eb419aca2b622bd45d --- /dev/null +++ b/643/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 cN0 squamous cell carcinoma was histologically confirmed <2014> in the area of the right edge and base of the tongue. With persistent pain in this area and unremarkable panendoscopy <2014>, computed tomography showed a cM0 situation. In our interdisciplinary tumor conference, the primary surgical procedure was recommended. \ No newline at end of file diff --git a/643/icd_codes.txt b/643/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cf422e8d9567fdb2464b75d4b6093c8a641ac4db --- /dev/null +++ b/643/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 R] \ No newline at end of file diff --git a/643/ops_codes.txt b/643/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7940c48d391a42f4bc5e972fbd363c7e9edfd513 --- /dev/null +++ b/643/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion der Zunge durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Transorale partielle Glossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.02 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Permanente Tracheotomie[5-312.0 ] Entnahme eines freien Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-904.0e R] Wechsel eines vaskulären Implantates[5-394.3 ] Laterale Pharyngotomie[5-290.3 ] \ No newline at end of file diff --git a/643/patient_clinical_data.json b/643/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a007e6552d8112d64a676efbf3659745e939a380 --- /dev/null +++ b/643/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 7, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/643/patient_pathological_data.json b/643/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d6d57434e1daf99e30d6c78303236652289c787b --- /dev/null +++ b/643/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "643", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 16.0 +} \ No newline at end of file diff --git a/643/surgery_description.txt b/643/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1e0d8ed340848c8b443bfd304d12b48a5e97c184 --- /dev/null +++ b/643/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Microvascular transplant diff --git a/643/surgery_report.txt b/643/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d98960e302eb2f41be6eec5d086193bdfb754ab --- /dev/null +++ b/643/surgery_report.txt @@ -0,0 +1 @@ +After enoral inspection and confirmation of the extent of the tumor, transoral resection is performed after exposure of the tumor as described above on the dorsal right edge of the tongue with transition and infiltration of the glossotonsillar groove. Cut around the tumor from a safety distance of 1.5 to 2 cm, especially in the area inside the tongue. Dorsal resection up to just below the midline, no deep or more extensive infiltration in the area of the base of the tongue. However, poor overview here. Partial resection of the posterior floor of the mouth. Exposure of the submandibular gland, but no infiltration here, but tumor cones behind the gland in depth. Therefore, after resection of the enoral part, including the right-sided tonsil and resection of the glossotonsillar groove, the decision was made to proceed transcervically. For this purpose, submandibular incision and cervical separation of skin and subcutaneous tissue. Separation and dissection of the platysma. Exposure and preservation of the external jugular vein and auricular nerve. Exposure of the sternocleidomastoid muscle, omohyoid muscle. Exposure of the submandibular gland and digastric muscle. First perform the neck dissection. Clear out the anterior neck preparation, carefully preserving the superior thyroid artery, the cervical artery, the facial vein and the hypoglossal nerve. Free preparation of the internal jugular vein, visualization of the accessorius nerve, clearing of the accessorius triangle and clearing of level V with careful protection of the cervical plexus branches. Macroscopically, no suspicious nodules on the right cervical side. Now release the submandibular gland and complete level Ib. Enter via the posterior floor of the mouth enorally. Separation of the digastric muscle, widening of the access to the enoral side, step-by-step good overview of the tumor and taking along circumscribed muscles of the floor of the mouth as the tumor cone grows. Resection of the tumor transcervically in toto. The specimen shows a clear safety margin on all sides, especially in the area deep to the tongue. Only in the area of the glossotonsillar groove and the posterior floor of the mouth is there a safety margin of approx. 1 cm on the specimen, otherwise significantly more. It was therefore decided to take marginal samples in this area. Taking marginal samples from the preparation. In the frozen section diagnostics, these are free of dysplasia and tumor, so that a safe R0 resection can be assumed here. With a tumor measuring an average of 4 cm on the specimen, a cT2 extension is clinically just present. Measure the defect of the posterior floor of the mouth, the edge of the tongue, the base of the tongue and the tonsil lobe. Neck dissection of the left side is then performed first. Here also submandibular incision. Separation of skin and subcutaneous tissue. Exposure and preservation of the external jugular vein, exposure of the limiting musculature. Clearing of levels II to IV with careful preservation of the superior thyroid artery, the facial vein, the cervical artery, the hypoglossal nerve, the accessory nerve and the internal jugular vein. No macroscopically conspicuous nodules here either. Inclusion of the caudal capsule of the submandibular gland. Finally, careful wound irrigation with Ringer's solution and, if the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Perform a plastic tracheostomy. Horizontal incision below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure of the infrahyoid musculature. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea, insertion between the 2nd and 3rd tracheal ring. Creation of a visor tracheotomy and insertion of the tracheostoma in the usual manner. Subsequent problem-free transfer to a size 8 low cuff cannula which is suture-fixed. Now to cover the defect. Elevation of the ALT from the right, here after doppler sonographic identification of the main perforator and two secondary perforators. Marking of the graft measuring 11 x 6 cm in total. Medial incision. Cutting through the fascia lata. Reliable identification of the rectus femoris muscle. Subfascial release. Identification of the pedicle vessel. Subsequent identification of the main perforator. Successive free preparation of the main perforator in the sense of a perforator flap. Isolation to the strong pedicle vessel. The sonographically identified secondary perforators are branches of the main perforator. Therefore, take along the main perforator, take along parts of the fascia lata, otherwise cut around the graft. Isolation on perforator and pedicle vessel. Conditioning of the pedicle vessels, elevation of a strong accompanying vein as well as a narrower second vein, and placement of the properly vital graft after the supply and return vessels have been treated. Careful wound inspection and, if the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Subsequent successive incorporation of the graft from the enoral and transcervical sides. This finally succeeds sufficiently with a good fit. Conditioning of the superior thyroid artery. Performing the arterial anastomosis with 8-0 Ethilon, this is sufficient and successful. Immediate regular venous return via the main vein. No flow via the second vein. Therefore occlusion of the vein. Conditioning of the superior thyroid vein. Measuring a coupler size 3.0 and performing the anastomosis with the coupler system. Subsequently, regular graft perfusion, regular pedicle pulsation and positive spreading phenomenon. Subsequent careful wound inspection and, if the wound is dry, insertion of a 10-gauge Redon drain. Positioning of the drain and careful two-layer wound closure and completion of the procedure without any indication of complications. Conclusion: Intraoperative R0 resected at least cT2 cN0 tongue margin carcinoma on the right. The patient received intraoperative intravenous antibiotics with Unacid 3 g, which should be continued for 24 hours postoperatively. If the enoral graft heals properly, attempt to swallow and gradually build up the diet from the 7th postoperative day. \ No newline at end of file diff --git a/644/InvasionFront_CD3_block6_x3_y5_patient644_0.json b/644/InvasionFront_CD3_block6_x3_y5_patient644_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bff428f1ff00084eb89739f6225d5bc66bb722d1 --- /dev/null +++ b/644/InvasionFront_CD3_block6_x3_y5_patient644_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12243.5, + "Centroid Y µm": 13068.1, + "Num Detections": 18583, + "Num Negative": 16982, + "Num Positive": 1601, + "Positive %": 8.615, + "Num Positive per mm^2": 681.86 + } +} \ No newline at end of file diff --git a/644/InvasionFront_CD3_block6_x4_y5_patient644_1.json b/644/InvasionFront_CD3_block6_x4_y5_patient644_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a13db99973c65c04796a52e4deeea9df08d05595 --- /dev/null +++ b/644/InvasionFront_CD3_block6_x4_y5_patient644_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14892.1, + "Centroid Y µm": 13193.0, + "Num Detections": 19033, + "Num Negative": 18450, + "Num Positive": 583, + "Positive %": 3.063, + "Num Positive per mm^2": 258.71 + } +} \ No newline at end of file diff --git a/644/InvasionFront_CD8_block6_x3_y3_patient644_0.json b/644/InvasionFront_CD8_block6_x3_y3_patient644_0.json new file mode 100644 index 0000000000000000000000000000000000000000..241b2b98ce21e4a9d0972787f56fa43c0de93206 --- /dev/null +++ b/644/InvasionFront_CD8_block6_x3_y3_patient644_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12643.3, + "Centroid Y µm": 7296.1, + "Num Detections": 17506, + "Num Negative": 16865, + "Num Positive": 641, + "Positive %": 3.662, + "Num Positive per mm^2": 266.05 + } +} \ No newline at end of file diff --git a/644/InvasionFront_CD8_block6_x4_y3_patient644_1.json b/644/InvasionFront_CD8_block6_x4_y3_patient644_1.json new file mode 100644 index 0000000000000000000000000000000000000000..37466b1c1921fc8705bba60fcd99847152f5a8a9 --- /dev/null +++ b/644/InvasionFront_CD8_block6_x4_y3_patient644_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15266.9, + "Centroid Y µm": 7496.0, + "Num Detections": 21226, + "Num Negative": 20182, + "Num Positive": 1044, + "Positive %": 4.918, + "Num Positive per mm^2": 405.96 + } +} \ No newline at end of file diff --git a/644/TumorCenter_CD3_block6_x3_y3_patient644_0.json b/644/TumorCenter_CD3_block6_x3_y3_patient644_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee2f734cfe653bb95c816fff1cebbf21b282fe6a --- /dev/null +++ b/644/TumorCenter_CD3_block6_x3_y3_patient644_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 7646.0, + "Num Detections": 9796, + "Num Negative": 8788, + "Num Positive": 1008, + "Positive %": 10.29, + "Num Positive per mm^2": 672.17 + } +} \ No newline at end of file diff --git a/644/TumorCenter_CD3_block6_x4_y3_patient644_1.json b/644/TumorCenter_CD3_block6_x4_y3_patient644_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0afbb2d3c285dece4efeb615af0b1c2d727da1ab --- /dev/null +++ b/644/TumorCenter_CD3_block6_x4_y3_patient644_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 7670.9, + "Num Detections": 11229, + "Num Negative": 10190, + "Num Positive": 1039, + "Positive %": 9.253, + "Num Positive per mm^2": 594.1 + } +} \ No newline at end of file diff --git a/644/TumorCenter_CD8_block6_x3_y3_patient644_0.json b/644/TumorCenter_CD8_block6_x3_y3_patient644_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e8aad9ccdf33c9cd3de3e7de5f4d3cfa8983016 --- /dev/null +++ b/644/TumorCenter_CD8_block6_x3_y3_patient644_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 8070.7, + "Num Detections": 21016, + "Num Negative": 20533, + "Num Positive": 483, + "Positive %": 2.298, + "Num Positive per mm^2": 194.81 + } +} \ No newline at end of file diff --git a/644/TumorCenter_CD8_block6_x4_y3_patient644_1.json b/644/TumorCenter_CD8_block6_x4_y3_patient644_1.json new file mode 100644 index 0000000000000000000000000000000000000000..772e5b06b2e1178a31d60c80ecea79ef587897d1 --- /dev/null +++ b/644/TumorCenter_CD8_block6_x4_y3_patient644_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 8070.7, + "Num Detections": 19548, + "Num Negative": 19237, + "Num Positive": 311, + "Positive %": 1.591, + "Num Positive per mm^2": 128.72 + } +} \ No newline at end of file diff --git a/644/history_text.txt b/644/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3529359d34e248f47ee6fd6da27af5bb17b9787f --- /dev/null +++ b/644/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the tongue margin/tongue body/base of tongue with infiltration of the extralingual soft tissues up to the submandibular gland on the right or just in front of the hyoid bone laterally, CT findings p16 negative, therefore surgical treatment indicated. \ No newline at end of file diff --git a/644/icd_codes.txt b/644/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b8f9b7cb4a0fbb0f863dfc11e6921830ae5941f2 --- /dev/null +++ b/644/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 B] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/644/ops_codes.txt b/644/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0eedcb62b2389d043e4763098d1856ef44aee65 --- /dev/null +++ b/644/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-303.14 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Entnahme von Spalthaut des Unterschenkels[5-901.0f R] Spalthaut bei Verbrennungen und Verätzungen Empfängerstelle Unterarm[5-925.08 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/644/patient_clinical_data.json b/644/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e01d1d9d1a4a5623ba98cce77e5ebbf96f5eb01a --- /dev/null +++ b/644/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 32, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/644/patient_pathological_data.json b/644/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7283a68056a071bde1fb2d7376385db478dd95a0 --- /dev/null +++ b/644/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "644", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN3", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 25.0 +} \ No newline at end of file diff --git a/644/surgery_description.txt b/644/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fd91391f8f6581755b856793b20590b39b44b77 --- /dev/null +++ b/644/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Defect coverage, Free flap (Radial), Tracheostomy, Endoscopy diff --git a/644/surgery_report.txt b/644/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d2d6181b233223466a465b3958a5107bb57126ac --- /dev/null +++ b/644/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again after nasotracheal intubation of the patient by the anesthesia colleagues: The exophytic tumor is seen, which extends to the glossoalveolar groove laterally at the back, infiltrating under the floor of the mouth in the direction of the submandibular space. Infiltration also towards the base of the tongue and here the midline is reached but not crossed. Overall indication for tumor resection, neck dissection and coverage with a radial flap. The apron flap is lifted first and a tracheostoma is created. Tracheotomy: Horizontal incision just below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Identification of the infralaryngeal musculature and division of the musculature in the midline. Push the musculature to the side and identify the cricoid cartilage. Sharp dissection of the cricoid cartilage and undermining of the thyroid isthmus. Bipolar coagulation of the thyroid isthmus and transection of the same. Identification of the anterior wall of the trachea. Careful removal of tissue from the anterior wall of the trachea. Tracheal incision in the 2nd to 3rd intratracheal ring space and creation of an epithelialized tracheostoma in the usual manner. Re-intubation with the 8-bore tracheostomy tube. PEG insertion: PEG insertion using the thread pull-through method. This is successful without any problems if the diaphanoscopy is positive. Tumor resection: First of all, cervical exposure of the cervical vessels as well as the hypoglossal nerve and vagus nerve. Snaring of these structures using Vessel-Loups. Vessels are dissected away from the soft tissue as far as the cranial side. The digastric muscle is severed and cut laterally and then resected at the lateral end. The mandible is exposed after pushing the soft tissues including the branch of the mouth cranially. The entire soft tissue is pushed away from the mandible with the periosteum from the angulus to the symphysis. Infrahyoid muscles are detached from the hyoid bone and dissected as a Remmert flap pedicled to the superior thyroid artery and the cervical artery and beaten downwards. The hyoid bone is then resected in the midline and included in the tumor resection together with all overlying soft tissue. The entire external musculature is resected in the midline. The entire dorsal body of the tongue, including the floor of the mouth and the largest parts of the sublingual gland, is resected transorally, except for the tip of the tongue. Resection also includes the areas of the tongue beyond the midline from the body of the tongue to the base of the tongue. The periosteum is also removed transorally from the lower jaw, the entire soft tissues and muscles of the floor of the mouth are also resected. The lingual nerve is also resected. In the further course of the operation, the hypoglossal nerve is also resected medial to the exit of the cervical nerve. The tumor is clearly resected macroscopically in healthy tissue and removed in toto. Multiple suture markings are made on the tumor, which is sent to the frozen section. Marginal samples of the mucosa are taken from the alveolar ridge to the floor of the mouth at the front, a further marginal sample of the mucosa from the middle of the tongue to the body with underlying soft tissue and soft tissue basally on the rest of the hyoid bone. All marginal samples and the marked tumor are sent for frozen section. Here, tumor in healthy tissue as well as marginal samples, thus R0 resection. Careful hemostasis and irrigation of the wound area and resection areas. The lingual artery and facial artery were already prepared as possible vascular anastomoses during the resection. The superior thyroid artery was included in the Remmert flap. Neck dissection on both sides by : skin incision and dissection through the subcutaneous fatty tissue. Subplatysmal dissection of the apron flap. Beginning on the right side. Exposure of the anterior border of the sternocleidomastoid muscle and dissection in depth. Finding the accessorius nerve and exposing it. Dissection of the omohyoid muscle and finding the submandibular gland. Elevation of the submandibular gland and protection of the marginal ramus. Exposure of the posterior venter of the digastric muscle up to region II b. Now expose and locate the accessorius nerve and protect it. Dissection of the internal jugular vein and its multiple outlets, including the facial vein. These are initially preserved, but then turned downwards to serve later as possible connecting vessels. Dissection of the jugulofacial angle and removal of multiple conspicuous lymph nodes. Protection of the hypoglossal nerve. Now dissection of the lateral neck preparation in regions II to V, sparing the vagus nerve and cervical plexus. The various branches of the external carotid artery are dissected in order to serve both as a Remmert flap and as connecting vessels. The lingual artery on the right side is removed. The cervical artery was also spared. On the left side, here too the anterior border of the sternocleidomastoid muscle is exposed and the accessorius nerve is located, protected and preserved. Exposure of the omohyoid muscle and the submandibular gland. Elevation of the gland, preserving the mandibular ramus and dissection on the digastric muscle posteriorly. Dissection along and on the internal jugular vein in a cranial direction. Here too, protect all outlets and the cervical vein. Follow the cervical vein to the hypoglossal muscle and preserve it. Now carefully dissect the lateral neck preparation and detach it while preserving the cervical plexus. It is cleared up to the omohyoid muscle, no chyle flow can be seen. There is also no increased bleeding. Now clear out the medial neck preparation, sparing all structures. The vagus nerve could also be visualized and preserved during the operation. The radial flap was then sutured into the defect. Successive suturing of the radial flap from the transcervical and transoral sides, partly after the sutures have been placed. The flap is successfully sutured in an anatomically three-dimensional manner so that both the lateral pharyngeal wall and floor of the mouth can be covered without tension, as well as the tongue and base of the tongue and the transition to the vallecula. The stalk is passed through the right side of the neck. Dissection of the facial vein, which has several outlets. Dissection of the facial artery. Anastomosis here, after conditioning the vessels with the radial artery. After opening the clamps, good arterial flow, good venous return. A branch of the facial vein is then anastomosed with the cephalic vein using a 3.5 mm coupler. The deep confluent vein is then anastomosed with another outlet from the facial vein using a 2.5 mm coupler. In each case, after opening the clamps, good venous flow and positive exclusion phenomenon. Overall, good blood flow after assessment of the flap. Extensive irrigation of the wound area. After further mobilization, the Remmert flap is sutured on the right side above the hyoid bone for volume augmentation. Subsequent careful hemostasis and irrigation of the wound area. Then wound closure in layers, with insertion of two flaps on the right and a Redon drain on the left and epithelialization of the tracheostoma. An 8 mm tracheostomy tube was then inserted and fixed in place. The defect on the forearm was primarily closed cranially and covered caudally with split skin, which was taken from the thigh on the right side. Defect augmentation using a Remmert flap from the right. Elevation of the radial forearm flap on the left by : Palpatory identification of the distal radial artery. Marking of the flap borders 14 cm x 8 cm on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Covering of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Finally, attachment of the forearm. Good saturation and blood circulation of the left forearm at the end of the operation. Completion of the procedure without complications. The patient is ventilated and transferred to the intensive care unit for monitoring. Please continue postoperative antibiotics with Unacid, as started intraoperatively, for one week. Nutrition via the inserted PEG tube for approx. 10 days, followed by an X-ray broth swallow and, if necessary, diet build-up. If necessary, initiate swallowing training in the voice and speech department. Control of the flap according to the scheme for 5 days by means of clinical checks and Doppler checks. Anastomosis area marked with right cervical suture. Awaiting the final histology. Then presentation at the interdisciplinary tumor conference to indicate radiochemotherapy if necessary. \ No newline at end of file diff --git a/645/InvasionFront_CD3_block7_x3_y6_patient645_0.json b/645/InvasionFront_CD3_block7_x3_y6_patient645_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dd90c5fb4c5da2d9ff7223a8b407b1606e3c6874 --- /dev/null +++ b/645/InvasionFront_CD3_block7_x3_y6_patient645_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11374.6, + "Centroid Y µm": 14626.5, + "Num Detections": 15319, + "Num Negative": 15117, + "Num Positive": 202, + "Positive %": 1.319, + "Num Positive per mm^2": 102.16 + } +} \ No newline at end of file diff --git a/645/InvasionFront_CD3_block7_x4_y6_patient645_1.json b/645/InvasionFront_CD3_block7_x4_y6_patient645_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b165b2e80a9cb1efd0569eb2b42dd7539eff505 --- /dev/null +++ b/645/InvasionFront_CD3_block7_x4_y6_patient645_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14030.1, + "Centroid Y µm": 14617.3, + "Num Detections": 17765, + "Num Negative": 17346, + "Num Positive": 419, + "Positive %": 2.359, + "Num Positive per mm^2": 173.62 + } +} \ No newline at end of file diff --git a/645/InvasionFront_CD8_block7_x3_y6_patient645_0.json b/645/InvasionFront_CD8_block7_x3_y6_patient645_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08edda707d91797f29c1d5f581a23896f3829f69 --- /dev/null +++ b/645/InvasionFront_CD8_block7_x3_y6_patient645_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12259.8, + "Centroid Y µm": 15296.0, + "Num Detections": 13330, + "Num Negative": 13240, + "Num Positive": 90, + "Positive %": 0.6752, + "Num Positive per mm^2": 46.97 + } +} \ No newline at end of file diff --git a/645/InvasionFront_CD8_block7_x4_y6_patient645_1.json b/645/InvasionFront_CD8_block7_x4_y6_patient645_1.json new file mode 100644 index 0000000000000000000000000000000000000000..92aee43b7ba6dc91c2b56fc933ac27da154b4258 --- /dev/null +++ b/645/InvasionFront_CD8_block7_x4_y6_patient645_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15017.0, + "Centroid Y µm": 15691.7, + "Num Detections": 15536, + "Num Negative": 15289, + "Num Positive": 247, + "Positive %": 1.59, + "Num Positive per mm^2": 105.42 + } +} \ No newline at end of file diff --git a/645/TumorCenter_CD3_block7_x3_y6_patient645_0.json b/645/TumorCenter_CD3_block7_x3_y6_patient645_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e22786b055492dffbf51bb9483fb255663fb62b9 --- /dev/null +++ b/645/TumorCenter_CD3_block7_x3_y6_patient645_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10969.2, + "Centroid Y µm": 15142.0, + "Num Detections": 15284, + "Num Negative": 14899, + "Num Positive": 385, + "Positive %": 2.519, + "Num Positive per mm^2": 163.27 + } +} \ No newline at end of file diff --git a/645/TumorCenter_CD3_block7_x4_y6_patient645_1.json b/645/TumorCenter_CD3_block7_x4_y6_patient645_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d9bfd04090ab280360b5e4bbd13e372c8c075610 --- /dev/null +++ b/645/TumorCenter_CD3_block7_x4_y6_patient645_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 14892.1, + "Num Detections": 14467, + "Num Negative": 14061, + "Num Positive": 406, + "Positive %": 2.806, + "Num Positive per mm^2": 187.51 + } +} \ No newline at end of file diff --git a/645/TumorCenter_CD8_block7_x3_y6_patient645_0.json b/645/TumorCenter_CD8_block7_x3_y6_patient645_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e75dbbda509f8543de853cd8a73cfe3aa77f07ab --- /dev/null +++ b/645/TumorCenter_CD8_block7_x3_y6_patient645_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10744.3, + "Centroid Y µm": 15167.0, + "Num Detections": 20008, + "Num Negative": 19946, + "Num Positive": 62, + "Positive %": 0.3099, + "Num Positive per mm^2": 25.66 + } +} \ No newline at end of file diff --git a/645/TumorCenter_CD8_block7_x4_y6_patient645_1.json b/645/TumorCenter_CD8_block7_x4_y6_patient645_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dc56ef15a9389863be53bab7898ec0876bd43d2f --- /dev/null +++ b/645/TumorCenter_CD8_block7_x4_y6_patient645_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 15117.0, + "Num Detections": 21217, + "Num Negative": 21125, + "Num Positive": 92, + "Positive %": 0.4336, + "Num Positive per mm^2": 36.93 + } +} \ No newline at end of file diff --git a/645/history_text.txt b/645/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2c094021f310cb0fc8c4c6929374ed7ceb1d2020 --- /dev/null +++ b/645/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy, the patient was found to have at least cT2 cN2b tongue margin carcinoma on the left side. Secondary findings included mediastinal lymphoma with tracheal invasion. After healing of extensive peritonitis and prior treatment of the lymphoma, the patient now presented for definitive treatment. Due to the secondary diseases, our interdisciplinary tumor conference decided that surgery was the treatment of choice. \ No newline at end of file diff --git a/645/icd_codes.txt b/645/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c240b330d89440dd5d87dcce35ef5abf9bec189 --- /dev/null +++ b/645/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Zunge mehrere Teilbereiche überlappend[C02.8 L] \ No newline at end of file diff --git a/645/ops_codes.txt b/645/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0bdd0c94b65c23646adea34b83a83f1bf3d8d52 --- /dev/null +++ b/645/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Partielle Resektion der Zunge durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Permanente Tracheotomie[5-312.0 ] Entnahme eines freien Lappens am Oberschenkel mit mikrovaskulärer Anastomosierung[5-904.0e R] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/645/patient_clinical_data.json b/645/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9b64167db8c73d5ce1be1c36ce21698a00e85fd2 --- /dev/null +++ b/645/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 97, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/645/patient_pathological_data.json b/645/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7c34945cd2076542672fcc2cf82c5a6bbbc5d0a7 --- /dev/null +++ b/645/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "645", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 7.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 25.0 +} \ No newline at end of file diff --git a/645/surgery_description.txt b/645/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4721fae21007130b50439015cc09511acc40bafc --- /dev/null +++ b/645/surgery_description.txt @@ -0,0 +1 @@ +Transoral and trans-cervical tumor resection, Neck dissection, Free flap (ALT) diff --git a/645/surgery_report.txt b/645/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1da2e6e5fce97692bc4dd2bf8294f4fc97b85143 --- /dev/null +++ b/645/surgery_report.txt @@ -0,0 +1 @@ +First of all, after intubation and preparation by the anesthesia colleagues, positioning of the patient. Inspection of the primary tumor region. An exophytic, exulcerated tumor is found in the area of the left edge of the tongue and the soft palate with involvement of the posterior floor of the mouth. Palpation reveals that the majority of the tumor is growing submucosally into the tongue. The tumor clearly extends beyond the midline in the area of the base of the tongue, but with sufficient residual distance to the opposite side. In addition, the tumor is clearly growing towards the floor of the mouth and cervically. Transoral tumor resection is therefore performed first. Removal of the soft palate section, taking the tonsil lobe with it, resection of the posterior floor of the mouth and resection of the exophytic tumor section up to the area of the edge of the tongue. This resection is completely covered with margin samples, which are diagnosed as tumor- and dysplasia-free in the frozen section diagnostics. Now continue the tumor resection from the transcervical side. Submandibular skin incision, separation of skin and subcutaneous tissue, dissection of the platysma. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, exposure of the hardened submandibular gland and the digastric muscle. The tumor can be palpated under the submandibular gland with infiltration of the lateral floor of the mouth. Due to the depth, first expose the vessels. Evacuation of the anterior neck preparation with removal of the facial vein and preservation of the superior thyroid artery. Exposure of the carotid artery and the internal jugular vein of the vagus nerve in the area of the internal jugular vein Level II and III, several macroscopically clearly suspicious nodules can be seen, but these can be separated from the accessorius nerve. Removal of the metastases in toto. Cranial dissection, resection of the digastric muscle. Release of the submandibular gland while sparing the ramus marginalis mandibulae. Palpation shows the tumor infiltrating the floor of the mouth up to just before the hyoid, here moderately displaceable, therefore involving the left half of the hyoid. Cranial dissection along the carotid artery. Separation of the facial artery and lingual artery. The hypoglossal nerve also appears to be pulling into the tumor conglomerate and is removed. Now successive extension of the pharyngotomy over the tonsillar lobe and the lateral floor of the mouth, continuing over the pharyngeal side wall up to the level of the vallecula. Resection as described of the hyoid with attached external floor of mouth muscles. Resection of the tumor within the tongue, leaving a muscle cuff on the tumor so that the final tumor can be resected macroscopically in sano; only at one point was there a muscle tear above the tumor capsule during dissection, which is marked. An extensive resection is performed to cover this area. Covering of the tumor in the marginal area and in the previously described muscular part with marginal samples, these are also diagnosed as tumor-free and dysplasia-free, so that a R0 situation can finally be assumed. Measurement of the defect. At the same time, the right-sided neck dissection was performed and the antero-lateral thigh graft was lifted to perform the neck dissection. A submandibular skin incision is also made here. Cutting through skin and subcutaneous tissue. Separation of the platysma. Dissection. Exposure of the sternocleidomastoid muscle and the omohyoid muscle. Exposure of the submandibular gland and digastric muscle. Release of the anterior neck preparation with careful protection of the hypoglossal nerve and the superior thyroid artery as well as the facial vein. Free preparation of the internal jugular vein. Exposure and preservation of the accessory nerve, evacuation of the accessory triangle and level V with careful protection of the cervical plexus branches. Final wound inspection and wound irrigation and, if the wound is dry, insertion of a 10-gauge Redon drain and careful two-layer wound closure. To elevate the antero-lateral thigh graft after doppler sonographic identification of a main perforator and three secondary perforators, the graft measuring a total of 15 x 10 cm with soft palate and tongue base configuration is indicated. Medial incision. Cut through skin and subcutaneous tissue. Exposure of the rectus femoris muscle. Strictly subfascial dissection. Identification of the pedicle vessel, which runs relatively cranially. The ramus descendens is relatively weak. Identification of the fasciocutaneous perforator, the secondary perforators run intramuscularly, complete resection of the graft. Partial entrainment of the fascia lata. Inclusion of a sufficient muscle cuff. Isolation to the pedicle vessel. Isolation on the artery and vein and, if the blood supply to the graft is normal, removal of the graft. Subsequent careful hemostasis. Insertion of a 10-gauge Redon drain and careful two-layer wound closure and adaptation of the skin edges. Subsequent successive insertion of the graft, primarily via the tanscervical area. Overall very good fit. Reconstruction of the entire tongue and reconstruction of the largely resected base of the tongue with good volume filling. Transoral completion in the area of the soft palate and floor of the mouth. Overall intact conditions on all sides. Cervical anastomosis conditions significantly more difficult due to the position of the anastomosis and the now somewhat obstructive muscle cuff. Conditioning of the detached lingual artery, arterial anastomosis performed with 8-0 Ethilon with good flow under markedly difficult suturing conditions with pronounced arteriosclerosis in the area of the graft vessel. Overall, however, intact anastomosis with immediate regular venous return. Conditioning of the facial vein in the stump area. Sizing of a coupler size 3.5 and insertion of the venous anastomosis without any problems using the coupler system. Subsequent regular graft perfusion. The muscle cuff can now be well integrated into the neck, resulting in a good position of the anastomosis, but also complete filling of the neck. Therefore, a caudal rubber flap is inserted later. Careful two-layer wound closure. Finally, the tracheotomy is performed. In this case, post-tracheotomy at the beginning of the year. Opening of the skin scar, cutting of scars. Exposure of the anterior surface of the trachea. Reopening of the trachea in the former area between the 1st and 2nd tracheal ring, followed by insertion of the muco-cutaneous anastomosis and problem-free reintubation onto a size 8 low cuff cannula, which is suture-fixed. The procedure was then completed with a vital graft. Conclusion: Intraoperative R0 resected cT4a cN2b tongue margin and tongue base carcinoma on the left. If the graft heals properly, the first attempts at swallowing can be started from the 8th postoperative day. Left cervical swelling due to the clear muscle cuff, please consult the surgeons before manipulation. Due to the extent of the tumor, adjuvant RCT appears to be urgently required. \ No newline at end of file diff --git a/646/InvasionFront_CD3_block12_x5_y2_patient646_0.json b/646/InvasionFront_CD3_block12_x5_y2_patient646_0.json new file mode 100644 index 0000000000000000000000000000000000000000..262383920983463fdc0796cc644173f8d86c02f1 --- /dev/null +++ b/646/InvasionFront_CD3_block12_x5_y2_patient646_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 10219.6, + "Num Detections": 18188, + "Num Negative": 16958, + "Num Positive": 1230, + "Positive %": 6.763, + "Num Positive per mm^2": 540.05 + } +} \ No newline at end of file diff --git a/646/InvasionFront_CD3_block12_x6_y2_patient646_1.json b/646/InvasionFront_CD3_block12_x6_y2_patient646_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a1bcf2bd5e4e321100b3b100c11b8acd06b404aa --- /dev/null +++ b/646/InvasionFront_CD3_block12_x6_y2_patient646_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19864.5, + "Centroid Y µm": 10494.4, + "Num Detections": 21503, + "Num Negative": 18714, + "Num Positive": 2789, + "Positive %": 12.97, + "Num Positive per mm^2": 1160.0 + } +} \ No newline at end of file diff --git a/646/InvasionFront_CD8_block12_x5_y2_patient646_0.json b/646/InvasionFront_CD8_block12_x5_y2_patient646_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65e18ca3fce5fdae6875ab26014f2da64491f70c --- /dev/null +++ b/646/InvasionFront_CD8_block12_x5_y2_patient646_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16791.1, + "Centroid Y µm": 8420.5, + "Num Detections": 16913, + "Num Negative": 16187, + "Num Positive": 726, + "Positive %": 4.293, + "Num Positive per mm^2": 344.62 + } +} \ No newline at end of file diff --git a/646/InvasionFront_CD8_block12_x6_y2_patient646_1.json b/646/InvasionFront_CD8_block12_x6_y2_patient646_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b70bed5f64ffea22feea289cd7586c1a5ede263e --- /dev/null +++ b/646/InvasionFront_CD8_block12_x6_y2_patient646_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19389.7, + "Centroid Y µm": 8395.6, + "Num Detections": 20433, + "Num Negative": 17477, + "Num Positive": 2956, + "Positive %": 14.47, + "Num Positive per mm^2": 1239.9 + } +} \ No newline at end of file diff --git a/646/TumorCenter_CD3_block12_x5_y2_patient646_0.json b/646/TumorCenter_CD3_block12_x5_y2_patient646_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e04faee4d3f0282a00cc0c1119fef4428a2dd553 --- /dev/null +++ b/646/TumorCenter_CD3_block12_x5_y2_patient646_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15966.5, + "Centroid Y µm": 4922.4, + "Num Detections": 19458, + "Num Negative": 16533, + "Num Positive": 2925, + "Positive %": 15.03, + "Num Positive per mm^2": 1343.5 + } +} \ No newline at end of file diff --git a/646/TumorCenter_CD3_block12_x6_y2_patient646_1.json b/646/TumorCenter_CD3_block12_x6_y2_patient646_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06b7c43e029a60f7b705be86354e54c6588f3476 --- /dev/null +++ b/646/TumorCenter_CD3_block12_x6_y2_patient646_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 4822.4, + "Num Detections": 19644, + "Num Negative": 18355, + "Num Positive": 1289, + "Positive %": 6.562, + "Num Positive per mm^2": 561.11 + } +} \ No newline at end of file diff --git a/646/TumorCenter_CD8_block12_x5_y2_patient646_0.json b/646/TumorCenter_CD8_block12_x5_y2_patient646_0.json new file mode 100644 index 0000000000000000000000000000000000000000..972ced895e8e45546a56f8ef846f27f05dcc7169 --- /dev/null +++ b/646/TumorCenter_CD8_block12_x5_y2_patient646_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19539.7, + "Centroid Y µm": 14542.3, + "Num Detections": 19920, + "Num Negative": 18403, + "Num Positive": 1517, + "Positive %": 7.615, + "Num Positive per mm^2": 705.45 + } +} \ No newline at end of file diff --git a/646/TumorCenter_CD8_block12_x6_y2_patient646_1.json b/646/TumorCenter_CD8_block12_x6_y2_patient646_1.json new file mode 100644 index 0000000000000000000000000000000000000000..26edc26b82530f2807ce23f7b0f7d083e1c0f68b --- /dev/null +++ b/646/TumorCenter_CD8_block12_x6_y2_patient646_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21963.4, + "Centroid Y µm": 14617.3, + "Num Detections": 18276, + "Num Negative": 17653, + "Num Positive": 623, + "Positive %": 3.409, + "Num Positive per mm^2": 270.5 + } +} \ No newline at end of file diff --git a/646/history_text.txt b/646/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..619bc87e04daa9a440d621a8415f0fafa6d95c68 --- /dev/null +++ b/646/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 cN2a oropharyngeal carcinoma on the right was confirmed during a panendoscopy. CT imaging showed a large lymph node metastasis measuring at least 4 cm in level II on the right, which was relatively close to the primary, in the tonsil region with a circumscribed transition to the base of the tongue. In addition, further conspicuous lymph nodes in level II on CT, therefore a cN2b neck status. No evidence of distant metastases. Indication for primary surgical treatment, in case of extensive defect also indication for defect coverage by radial artery graft. \ No newline at end of file diff --git a/646/icd_codes.txt b/646/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/646/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/646/ops_codes.txt b/646/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ae6368167f6d726242b734362feb739092c0da8 --- /dev/null +++ b/646/ops_codes.txt @@ -0,0 +1 @@ +Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.x0 ] Tonsillektomie radikal transoral[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/646/patient_clinical_data.json b/646/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9e430cb8746760e0f593925cee37ba3b43d22cf4 --- /dev/null +++ b/646/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/646/patient_pathological_data.json b/646/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0ebcef11dbbf8020fe9317dfd9d08460db777ec6 --- /dev/null +++ b/646/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "646", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 15.0 +} \ No newline at end of file diff --git a/646/surgery_description.txt b/646/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..59fa39428e621c23768d05d4fce624747c395cdb --- /dev/null +++ b/646/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection diff --git a/646/surgery_report.txt b/646/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9eb365bd996ad79ed41970c1f849eb721ec75454 --- /dev/null +++ b/646/surgery_report.txt @@ -0,0 +1 @@ +After intubation by the anesthesia colleagues, the patient is positioned. First of all, PEG insertion: for this purpose, insertion with a flexible gastroscope under laryngoscopic control. Easy to see through to the stomach. This appears regular and free. With a regular diaphanoscopy, the stomach is punctured without any problems and the PEG tube is inserted using the usual suture pull-through method. This was without any problems. No abnormalities on inspection of the oesophagus, apart from a few tablet residues. First, a pharyngo/laryngoscopy was performed to determine the extent of the tumor: an exophytic and ulcerated tumor was found in the area of the left tonsil lobe, which was largely limited to the tonsil region. In the area of the right edge of the tongue, superficial fleshy, reddish tissue, questionable as a tumor extension, which shows no deep infiltration on palpation. Relatively good mobility on palpation of the tumor, no deep infiltration. Free posterior pharyngeal wall, no growth towards the nasopharynx. Further tongue base, vallecula and epiglottis are free. The caudal tonsil is relatively fleshy. Here rather no tumor growth. Therefore, we now turn to primary enoral resection. Expose the tumor with the tonsil retractor and the Jennings retractor while looping the tongue. Inclusion of the entire anterior palatal arch to gain an overview. Resection to just parauvular. Therefore good mobilization of the tumour. Resection of the tumor in toto with removal of muscles in the area of the posterior palatal arch. Here the tumor is smoothly bordered and encapsulated, without tissue adherence. Relatively easy detachment without capsular injury. Caudal resection is also problem-free. The fleshy change in the area of the right or posterior right edge of the tongue is now removed with a safety margin of a good 1 cm. Free conditions in the depth here. Removal of approx. 1/2 cm of muscle cuff. Circumscribed resection of the glossotonsillar groove. However, this otherwise remains largely intact. There is also no resection towards the floor of the mouth. Involvement of the entire tonsil including the caudal change. Therefore resection up to the level of the epiglottis. Minutious hemostasis using bipolar coagulation. After extirpation of the tumor, re-inspection. In the area of the posterior pharyngeal wall, a macroscopically narrow resection distance can be seen medially. The capsule of the tumor can be seen circumscribed caudally. However, there is no breakthrough or open tissue. Therefore, a complete resection was first made in the area of the posterior pharyngeal wall and parauvularly up to the caudal margin. Now insert the entire specimen, which is marked on all sides, and the resected specimen for frozen section diagnostics. With a short resection distance in the area of the posterior pharyngeal wall, the post-resection is now exposed here. Basally in the cranial part, the resection distance is very short here with the capsule partially exposed, as described. The resection margin in the area of the anterior palatal arch is also narrow, otherwise the resection margins are macroscopically and microscopically tumor-free on all sides, especially in the area of the tongue. Therefore, at a later stage, a resection and a final margin specimen are formed in the area of the entire anterior palatal arch and in the area of the wound bed in the area of the posterior palatal arch, covering it completely. The final marginal sample is diagnosed as tumor-free at both sites in the frozen section diagnostics. Therefore, no further measures are required. Minutious hemostasis and check for blood dryness. On palpation, even before the necks are performed, a clear soft tissue mantle is still visible in addition to the clearly palpable metastasis in level II on the right. Therefore, we now turn to the neck dissections, starting with the neck dissection on the left: After repositioning and instillation of xylocaine with the addition of adrenaline, start on the left side: curved skin incision submandibularly and on the anterior edge of the sternocleidomastoid. Cut through skin and subcutaneous tissue. Separation of the platysma. Creation of a platysma flap. Exposure of the sternocleidomastoid muscle, the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery, the facial vein and the cervical vein. Free preparation of the internal jugular vein after prior exposure and protection of the accessorius nerve. Clearing of the accessorius triangle with careful protection of the nerve. Subsequent evacuation of level V with careful protection of the plexus branches. No evidence of lymphatic leakage caudally. Subsequent careful wound inspection and wound irrigation with Ringer's solution and, if wound conditions are dry and level IIa to V is completely evacuated, insertion of a 10 Redon drain in the case of clinical cN0 aspect and later careful two-layer wound closure after checking again for blood dryness. Turning now to the opposite side: Here also skin incision, submandibularly curved at the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Separation of the platysma. Creation of a platysma flap. Palpation of the metastasis, which is mainly located in level IIa, appears to measure approx. 4 x 5 cm and is relatively easy to move with the surrounding area. Palpatorily no infiltration of the sternocleidomastoid muscle or adherence to other structures. Therefore, visualization of the sternocleidomastoid muscle at level II of the metastasis on the muscle without signs of muscle infiltration for ............. a safety margin. Inclusion of a circumscribed muscle cuff. Expose the omohyoid muscle at this point. Exposure of the submandibular gland. Exposure of the digastric muscle. Removal of the anterior neck preparation with exposure and preservation of the facial vein, the hypoglossal nerve and the superior thyroid artery. Ansa cervicalis was removed here. Now free preparation of the internal jugular vein. The large mass is seen in level IIa, lying directly on the vein in the area of the jugulofacial angle, but here there is no evidence of infiltration with strict vascular dissection. In addition, level III, located directly on the internal jugular vein, shows a nodular lymph node change measuring approx. 2 x 2 1/2 cm. Confirmation of the CT findings. Visualization of the accessorius nerve. The metastasis lies on the nerve, but clearly does not infiltrate it. The metastasis can be easily detached from the nerve. After complete visualization of the digastric muscle, detachment from the metastasis is also possible. Good caudal detachment from the caudal parotid pole. Here only adjacent metastasis, no evidence of infiltration. Overall metastasis limited to the lymph node, measuring approx. 4 x 5 cm, which is removed in toto. Finally, the accessorius triangle was removed, carefully sparing the nerves, and Levl V was removed, carefully sparing the plexus, with no evidence of lymphatic leakage. Now, after complete removal of the neck resectate, inspection of the wound cavities, especially palpation towards level IIa, towards the tonsil lobe. Here, palpation also reveals a clear soft tissue mantle and a well-protected carotid artery. Findings demo and case discussion with . Due to the non-penetrating defect of the stable soft tissue mantle, confirmation of the extent and also no indication for radial flap coverage. Therefore, careful inspection of the wound surfaces. Irrigation with H2O2 and Ringer's solution. If the wound is dry, insertion of a 10 Redon drain and careful two-layer wound closure. The previously dictated resections are now carried out. Final wound inspection. After meticulous hemostasis, the wound is dry. A relatively large wound area is now visible. After resection of the anterior palatal arch, resection towards the soft palate, resection up to the posterior pharyngeal wall and resection in the area of the pharynx caudal to the level of the epiglottis as well as circumscribed resection of the edge of the tongue. Due to the large wound area and extent, the decision was made to perform a protective tracheostomy. Prior to this, the wound surfaces in the area of the tongue edge are adapted with 3.0 Vicryl. Also adaptation of muscle cords in the area of the posterior pharyngeal wall and parauvular tissue. Finally, inspection under dry conditions. Finally, perform the tracheotomy: modified Kocher collar incision, approx. 1 cm below the relatively deep cricoid cartilage. Very short distance between jugulum and cricoid cartilage. Cut through skin and subcutaneous tissue. A very strong, pronounced vein is seen subcutaneously, almost the caliber of an internal jugular vein. This is exposed, ligated and ligated. Further exposure of the infrahyoid musculature. Entering the linea alba. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea. The glandular isthmus is relatively weakly developed and is coagulated. Exposure of the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring. Creation of a Björk flap and insertion of the tracheostoma in the usual manner. Finally, problem-free transfer to an 8 mm tracheoflex cannula and completion of the procedure at this point. Conclusion: Intraoperative R0-resected cT2 cN2b oropharyngeal carcinoma on the right with protective tracheostomy and extensive resection area, but with good conditions for primary wound healing. After a swallowing test, a liquid diet can be started from the 3rd postoperative day. If swallowing function and wound development are normal, decannulation may be possible from the 5th to 7th postoperative day. After receiving the definitive histology, presentation at our interdisciplinary tumor conference. Due to the aggressive metastasis, adjuvant therapy is certainly required here. \ No newline at end of file diff --git a/647/InvasionFront_CD8_block19_x5_y12_patient647_0.json b/647/InvasionFront_CD8_block19_x5_y12_patient647_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1221643abaa364d0b60efc3936527a9289d7bd7b --- /dev/null +++ b/647/InvasionFront_CD8_block19_x5_y12_patient647_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15883.9, + "Centroid Y µm": 39913.6, + "Num Detections": 18659, + "Num Negative": 18603, + "Num Positive": 56, + "Positive %": 0.3001, + "Num Positive per mm^2": 29.14 + } +} \ No newline at end of file diff --git a/647/InvasionFront_CD8_block19_x6_y12_patient647_1.json b/647/InvasionFront_CD8_block19_x6_y12_patient647_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0cc01c0e388569c3d1086e430ef30730c52da71d --- /dev/null +++ b/647/InvasionFront_CD8_block19_x6_y12_patient647_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18396.0, + "Centroid Y µm": 40021.3, + "Num Detections": 16582, + "Num Negative": 16484, + "Num Positive": 98, + "Positive %": 0.591, + "Num Positive per mm^2": 51.02 + } +} \ No newline at end of file diff --git a/647/TumorCenter_CD3_block19_x5_y12_patient647_0.json b/647/TumorCenter_CD3_block19_x5_y12_patient647_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5807b5cd8e1cab75c2327dd206d8ff48a80cc725 --- /dev/null +++ b/647/TumorCenter_CD3_block19_x5_y12_patient647_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18716.4, + "Centroid Y µm": 30290.5, + "Num Detections": 12991, + "Num Negative": 12942, + "Num Positive": 49, + "Positive %": 0.3772, + "Num Positive per mm^2": 28.46 + } +} \ No newline at end of file diff --git a/647/TumorCenter_CD3_block19_x6_y12_patient647_1.json b/647/TumorCenter_CD3_block19_x6_y12_patient647_1.json new file mode 100644 index 0000000000000000000000000000000000000000..168810da987cf89660b05cfed5d2f875d897beae --- /dev/null +++ b/647/TumorCenter_CD3_block19_x6_y12_patient647_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21095.0, + "Centroid Y µm": 29998.4, + "Num Detections": 18175, + "Num Negative": 18128, + "Num Positive": 47, + "Positive %": 0.2586, + "Num Positive per mm^2": 25.31 + } +} \ No newline at end of file diff --git a/647/TumorCenter_CD8_block19_x5_y12_patient647_0.json b/647/TumorCenter_CD8_block19_x5_y12_patient647_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a2f2e1e562a12f13e90c329f256b0a25d3a994b6 --- /dev/null +++ b/647/TumorCenter_CD8_block19_x5_y12_patient647_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 41228.2, + "Num Detections": 18019, + "Num Negative": 18008, + "Num Positive": 11, + "Positive %": 0.061, + "Num Positive per mm^2": 5.733 + } +} \ No newline at end of file diff --git a/647/TumorCenter_CD8_block19_x6_y12_patient647_1.json b/647/TumorCenter_CD8_block19_x6_y12_patient647_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8890b88d28424301dd670755d0d29733e5e56619 --- /dev/null +++ b/647/TumorCenter_CD8_block19_x6_y12_patient647_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21113.8, + "Centroid Y µm": 41253.2, + "Num Detections": 20238, + "Num Negative": 20197, + "Num Positive": 41, + "Positive %": 0.2026, + "Num Positive per mm^2": 20.95 + } +} \ No newline at end of file diff --git a/647/history_text.txt b/647/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..01869386d3247f7b736668bb0e5e39c67dacb6a7 --- /dev/null +++ b/647/history_text.txt @@ -0,0 +1 @@ +The patient has a laryngeal carcinoma on the left side, which extends into the anterior commissure and breaks through the thyroid cartilage to the front. The arytenoid cartilage of the left side also appears to be infiltrated by the tumor, so that the above-mentioned indication for surgery was given. \ No newline at end of file diff --git a/647/icd_codes.txt b/647/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..31f58876b28caf6583e662fc242ecb509734f250 --- /dev/null +++ b/647/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 L] \ No newline at end of file diff --git a/647/ops_codes.txt b/647/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c41bd610384f22699cf6e74203cc41782a92e076 --- /dev/null +++ b/647/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/647/patient_clinical_data.json b/647/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0e9265b70d58c24271846ba0c3d1a01a45f37819 --- /dev/null +++ b/647/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/647/patient_pathological_data.json b/647/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..98539cfedeaf1823d2a1ef73dd6cd0c4374ca62b --- /dev/null +++ b/647/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "647", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/647/surgery_description.txt b/647/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d1e7acb0d004b9092232202492884c217e0728c2 --- /dev/null +++ b/647/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection, Tracheostomy diff --git a/647/surgery_report.txt b/647/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c9f885a409fcb63bf91e85b84dcfbda0c1eddd65 --- /dev/null +++ b/647/surgery_report.txt @@ -0,0 +1 @@ +After induction of intubation anesthesia, repeat microlaryngoscopy and check of the tumor extent, which has not changed since the previous examination. Then injection of local anesthetic with adrenaline and transverse skin incision over the thyroid cartilage. Layer-by-layer preparation in depth. Exposure of the thyroid cartilage surface reveals the tumor that has migrated through. This exposes the entire thyroid cartilage surface and the cricoid cartilage. Then open the thyroid cartilage paramedian on the right with the wheel. Then make a vertical incision paramedian on the left with the wheel. Now push off the periosteum, initially on the left side. Then also a little on the right side. Then open the endolarynx paramedian on the right. The tumor on the left is clearly visible here. The tumor is now first removed from the right vocal fold with a safety margin of 2-3 mm and dissected to the left side. There, resection of the entire anterior commissure en bloc with the attached thyroid cartilage and resection of the endolarynx on the left side at the glottis level up to the subglottic level and up to the middle level of the pouch ligament on the left side. It can be seen that the tumor clearly infiltrates the ary, so that this is disarticulated and also removed. The tumor is then removed at the interarytaenoid muscles. A marginal sample is taken here. Similarly, removal of marginal samples in the area of the margin on the right side. It then becomes apparent that the tumor possibly extends to the cricoid cartilage here, so here too cricoid cartilage is initially removed basally and ventrally. The dorsal edge sample and the edge sample in the interarytaenoid area are not diagnosed as reliably tumor-free, so a resection is performed here. A second marginal sample is then taken from the dorsal area of the cricoid cartilage and the interarytaenoid muscles. These are then found to be tumor-free intraoperatively. Therefore, the cricoid cartilage plate and the articular surface of the cricoarytaenoid joint are now abraded. The tumor is thus resected in consideration of the marginal specimens R0. The incision is then made further caudally in front of the trachea and dissected in layers in depth. Separation of the infralaryngeal musculature. Exposure of the thyroid isthmus. This is first undermined and then cut on both sides. Repeated exposure of the anterior surface of the trachea. Then open the trachea between the 2nd and 3rd cartilage rod. Preparation of a Björk flap and subsequent circular mucocutaneous anastomosis of the tracheostoma. Then reintubation. After subtle endolaryngeal hemostasis, readaptation of the pouch ligament on the left side and of the vocal fold and pouch ligament on the right side, which are fixed to the thyroid cartilage framework with PDS sutures. The thyroid cartilage surface is covered with a dorsally pedicled mucosal flap. The same applies to the articular surface of the arytaenoid joint on the left side. Then check the bleeding again. Then adaptation and suturing of the two thyroid cartilage surfaces. A small remaining gap is closed with prelaryngeal muscle pedicled from the left. A wound flap is then inserted and the wound is closed in two layers. After applying a dressing and inserting a nasogastric feeding tube, the procedure is completed. In the case of cN0 neck status, neck dissection is not performed on both sides. The patient was shielded intraoperatively with intravenous antibiotics with Unacid, which should be continued until the 3rd postoperative day. An attempt to swallow is possible after about 8 days. Until then, the patient should be fed via the nasogastric feeding tube. Depending on the result of the swallowing test, the patient can then be given a diet or swallowing training. \ No newline at end of file diff --git a/648/InvasionFront_CD3_block9_x1_y2_patient648_0.json b/648/InvasionFront_CD3_block9_x1_y2_patient648_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fd054b41d0ad51c4a0b9e26837c1961057f7855c --- /dev/null +++ b/648/InvasionFront_CD3_block9_x1_y2_patient648_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 5097.3, + "Num Detections": 21451, + "Num Negative": 20066, + "Num Positive": 1385, + "Positive %": 6.457, + "Num Positive per mm^2": 579.1 + } +} \ No newline at end of file diff --git a/648/InvasionFront_CD3_block9_x2_y2_patient648_1.json b/648/InvasionFront_CD3_block9_x2_y2_patient648_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c1d0d604b4c523cd15f9be648186970775632d8 --- /dev/null +++ b/648/InvasionFront_CD3_block9_x2_y2_patient648_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8820.3, + "Centroid Y µm": 5372.2, + "Num Detections": 19758, + "Num Negative": 19152, + "Num Positive": 606, + "Positive %": 3.067, + "Num Positive per mm^2": 255.38 + } +} \ No newline at end of file diff --git a/648/InvasionFront_CD8_block9_x1_y2_patient648_0.json b/648/InvasionFront_CD8_block9_x1_y2_patient648_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebe022d74a20f9c3712309838db1e5bd8c208954 --- /dev/null +++ b/648/InvasionFront_CD8_block9_x1_y2_patient648_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5722.0, + "Centroid Y µm": 9619.9, + "Num Detections": 22613, + "Num Negative": 19964, + "Num Positive": 2649, + "Positive %": 11.71, + "Num Positive per mm^2": 1098.7 + } +} \ No newline at end of file diff --git a/648/InvasionFront_CD8_block9_x2_y2_patient648_1.json b/648/InvasionFront_CD8_block9_x2_y2_patient648_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2fd02f953135451944d437c1d77198398dd3ebbe --- /dev/null +++ b/648/InvasionFront_CD8_block9_x2_y2_patient648_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8345.6, + "Centroid Y µm": 9894.8, + "Num Detections": 23195, + "Num Negative": 22032, + "Num Positive": 1163, + "Positive %": 5.014, + "Num Positive per mm^2": 479.64 + } +} \ No newline at end of file diff --git a/648/TumorCenter_CD3_block9_x1_y2_patient648_0.json b/648/TumorCenter_CD3_block9_x1_y2_patient648_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a32a321544cb8380753be4afae4feec6b3b5685a --- /dev/null +++ b/648/TumorCenter_CD3_block9_x1_y2_patient648_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4447.6, + "Centroid Y µm": 10569.4, + "Num Detections": 23479, + "Num Negative": 22182, + "Num Positive": 1297, + "Positive %": 5.524, + "Num Positive per mm^2": 525.23 + } +} \ No newline at end of file diff --git a/648/TumorCenter_CD3_block9_x2_y2_patient648_1.json b/648/TumorCenter_CD3_block9_x2_y2_patient648_1.json new file mode 100644 index 0000000000000000000000000000000000000000..35d556767b9fd6b9c1b261805bfe5501919cf651 --- /dev/null +++ b/648/TumorCenter_CD3_block9_x2_y2_patient648_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7046.3, + "Centroid Y µm": 10719.3, + "Num Detections": 24267, + "Num Negative": 22105, + "Num Positive": 2162, + "Positive %": 8.909, + "Num Positive per mm^2": 817.36 + } +} \ No newline at end of file diff --git a/648/TumorCenter_CD8_block9_x1_y2_patient648_0.json b/648/TumorCenter_CD8_block9_x1_y2_patient648_0.json new file mode 100644 index 0000000000000000000000000000000000000000..275f3f6110979e82da9a2cdf5df8ccf5b8de0e33 --- /dev/null +++ b/648/TumorCenter_CD8_block9_x1_y2_patient648_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 6221.7, + "Num Detections": 24063, + "Num Negative": 22688, + "Num Positive": 1375, + "Positive %": 5.714, + "Num Positive per mm^2": 568.49 + } +} \ No newline at end of file diff --git a/648/TumorCenter_CD8_block9_x2_y2_patient648_1.json b/648/TumorCenter_CD8_block9_x2_y2_patient648_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0fbc63a92bc2fb74ec831580f434e2a9f86034be --- /dev/null +++ b/648/TumorCenter_CD8_block9_x2_y2_patient648_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 5996.8, + "Num Detections": 25871, + "Num Negative": 23853, + "Num Positive": 2018, + "Positive %": 7.8, + "Num Positive per mm^2": 763.64 + } +} \ No newline at end of file diff --git a/648/history_text.txt b/648/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0a228688afab50ebed26edd24aedf1ac1144d564 --- /dev/null +++ b/648/history_text.txt @@ -0,0 +1 @@ +Patient with carcinoma of the base of the tongue which had been histologically confirmed by previous endoscopy. In CT and ultrasound, midline crossing to the right, in CT approx. 1/2 cm, in sonogram slightly above. Size approx. 2 x 3 cm. \ No newline at end of file diff --git a/648/icd_codes.txt b/648/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fee5f62048ff6bb507378ac92fc0824bb41b5a0 --- /dev/null +++ b/648/icd_codes.txt @@ -0,0 +1 @@ +Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/648/ops_codes.txt b/648/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8cb88549765509bcb8d535385a43cba0d5a2e526 --- /dev/null +++ b/648/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Perkutan-endoskopische Gastrostomie[5-431.2 ] Temporäre Tracheotomie[5-311.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/648/patient_clinical_data.json b/648/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d735e7c39dcd30c48a603ed07f0597df4e88d076 --- /dev/null +++ b/648/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 42, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/648/patient_pathological_data.json b/648/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3deefcd70e1f375f296525fb610a702eb0dcb9d6 --- /dev/null +++ b/648/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "648", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/648/surgery_description.txt b/648/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5ff204108ebdbec442f4565f3fbfba22e524f3d4 --- /dev/null +++ b/648/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Neck dissection, Tracheotomy diff --git a/648/surgery_report.txt b/648/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d51416e1ebc6b20ddc485eda1ccbb5794e845d56 --- /dev/null +++ b/648/surgery_report.txt @@ -0,0 +1 @@ +This is followed by pharyngoscopy and laryngoscopy: The tumorous process is visible, which extends from the left pharyngoepiglottic plica over the base of the tongue and vallecula area to the midline to the right by about 1 cm. Involvement of the vallecula, the left epiglottis and the caudal base of the tongue. Deep tumor crater to the left. Laser resection now follows: positioning of the tumor with a spreading laryngoscope. The tumor is removed macroscopically at a distance of approx. 1 cm on all sides in healthy tissue. Resection extends from the right paramedian to the left just below the tonsil lobe. The entire base of the tongue is resected caudally and the hyoid bone is exposed, almost over the entire plane. Complete vallecular resection, resection of the left mucosa of the epiglottis except for a small region just in front of the point of envelope. The specimen is removed, thread-marked and sent for frozen section. In addition, a wide mass from the entire cranial region is sent in. The specimen is relatively scarce in the cranial direction, but is well covered by the cranial margin specimen, which is healthy. Tumor cells are still scattered laterally to the right and especially caudally to the right. However, intraepithelial lymphangiosis is also detectable towards the depth. Therefore another resection to the right, very carefully so as not to damage the lingual artery. The left lingual artery had already been closed with clips. Resection of this 1 cm wide strip with underlying soft tissue now follows. Resection extends from right lateral cranial to right lateral caudal, including the lateral parts of the epiglottis. Strip is sent in, no more tumor infiltrates here. Thus an overall R0 situation. Careful hemostasis is now performed. Resection was performed using a 5-6 watt superpulse laser. The patient is now transferred for modified radical neck dissection and tracheostomy. First decision to insert a PEG tube in the typical manner. This is done without complications using the suture pull-through method with adequate diaphanoscopy. A neck dissection is then performed on the right side. Creation of a skin incision along the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Dissection of the platysma. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure in the depth of the nervus accessorius, the omohyoid muscle and the digaster muscle. Dissection of the above-mentioned structures revealed several highly visible masses in regions II to V b, partly with the sternocleidomastoid muscle caudally with the omohyoid muscle, especially the masses in regions IV and V b were broadly adjacent to the internal jugular vein. First attempt to dissect along the cervical vascular sheath. Difficult dissection, scarred conditions. Exposure and protection of the vagus nerve and the common carotid artery. Removal of the posterior neck specimen together with the highly suspicious mass in regions II to IV while sparing the above-mentioned structures. Removal of fibers of the sternocleidomastoid muscle in the neck preparation. Hemostasis using bipolar coagulation. Protection of the deep plexus branches. Then concentrate on the highly suspicious mass in regions IV and V b. Dissection of the omohyoid muscle. Inclusion of fibers of the omohyoid muscle in the preparation. Heavily scarred conditions. It is then possible to first find a layer on the internal jugular vein and then to detach the large conglomerate of Regio IV and V b from the internal jugular vein. Hemostasis using bipolar coagulation. Subsequent removal of the anterior neck specimen. Hemostasis using bipolar coagulation. Wound irrigation using hydrogen peroxide and Ringer's solution. Placement of a 10 Redon drain. Two-layer wound closure. Now repositioning of the patient to perform a neck dissection on the left side. Sonographic cN3 neck status with a large mass over 6 cm in regions II and III and two small, highly suspicious masses, cystically altered, in regions IV and V b. Creation of a skin incision along the anterior edge of the sternocleidomastoid muscle. Cut through the skin, the subcutaneous tissue and the platysma. Expose and dissect along the anterior border of the sternocleidomastoid muscle. In this step, the N3 metastasis in regions II and III is already encountered, which appears cystically altered. Dissection along this mass in regions II and III, exposing the posterior belly of the digastric muscle and the capsule of the submandibular gland, which is removed from the specimen. Inclusion of fibers of the sternocleidomastoid muscle in the preparation. The nervus accessorius cannot be preserved due to clear infiltration and is removed with the preparation. Subcutaneous tissue from region V and muscle fibers of the scalene muscles are included in the preparation. Hemostasis using bipolar coagulation. Subsequent dissection from cranial to caudal. Removal of the neck specimen together with the highly suspicious mass in region IV. Very careful, laborious dissection in region V b. Removal of the neck specimen in toto. Extensive hemostasis in region V b using bipolar coagulation. Exposure and protection of the neck vessel sheath. Extremely difficult dissection in region V b. This results in a small tear in the internal jugular vein, which is immediately treated using Vascufil suture 6-0. Removal of the anterior neck specimen. Hemostasis using bipolar coagulation. Placement of a 10 Redon drain and two-layer wound closure and completion of the neck dissection on the left side. Due to the large wound area ..... and the left vallecula and the expected pronounced dysphagia, the decision was made to perform a tracheostomy in the typical manner. Creation of a skin incision directly below the level of the cricoid cartilage, approx. 3 cm long. Cut through the subcutaneous tissue. Exposure of the prelaryngeal musculature. Exposure of the anterior wall of the thyroid isthmus. Undermining of the thyroid isthmus using Pean clamps. Separation of the thyroid isthmus and ligation of both thyroid stumps. Exposure of the anterior wall of the trachea. Creation of a tracheal incision between the 2nd and 3rd tracheal cartilage clasp. Creation of a Björk flap in the typical manner and epithelialization of the tracheostoma. Reintubation to a size 8 Rügheim tracheostomy tube. Completion of the procedure without complications. Transfer of the patient to the intensive care unit. Feeding for at least 1 week via PEG tube, then cautious diet build-up. Due to the overall situation, postoperative RCT should certainly be discussed in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/649/InvasionFront_CD3_block12_x1_y7_patient649_0.json b/649/InvasionFront_CD3_block12_x1_y7_patient649_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6104cea3a60b763665ad9dc459f3ec061d8d665a --- /dev/null +++ b/649/InvasionFront_CD3_block12_x1_y7_patient649_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 21813.5, + "Num Detections": 20464, + "Num Negative": 19510, + "Num Positive": 954, + "Positive %": 4.662, + "Num Positive per mm^2": 433.9 + } +} \ No newline at end of file diff --git a/649/InvasionFront_CD3_block12_x2_y7_patient649_1.json b/649/InvasionFront_CD3_block12_x2_y7_patient649_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ca8cb6096089eff50be0d385350f0704fbd8a838 --- /dev/null +++ b/649/InvasionFront_CD3_block12_x2_y7_patient649_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 21913.4, + "Num Detections": 18717, + "Num Negative": 18331, + "Num Positive": 386, + "Positive %": 2.062, + "Num Positive per mm^2": 178.45 + } +} \ No newline at end of file diff --git a/649/InvasionFront_CD8_block12_x1_y7_patient649_0.json b/649/InvasionFront_CD8_block12_x1_y7_patient649_0.json new file mode 100644 index 0000000000000000000000000000000000000000..213c8d236ab7c2139c7606a638012783ee067d0f --- /dev/null +++ b/649/InvasionFront_CD8_block12_x1_y7_patient649_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4722.5, + "Centroid Y µm": 21863.4, + "Num Detections": 20868, + "Num Negative": 20453, + "Num Positive": 415, + "Positive %": 1.989, + "Num Positive per mm^2": 187.14 + } +} \ No newline at end of file diff --git a/649/InvasionFront_CD8_block12_x2_y7_patient649_1.json b/649/InvasionFront_CD8_block12_x2_y7_patient649_1.json new file mode 100644 index 0000000000000000000000000000000000000000..00311c8b26b34e5e1fc4e66df4353b0618efd713 --- /dev/null +++ b/649/InvasionFront_CD8_block12_x2_y7_patient649_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7396.1, + "Centroid Y µm": 21663.5, + "Num Detections": 18114, + "Num Negative": 18018, + "Num Positive": 96, + "Positive %": 0.53, + "Num Positive per mm^2": 44.02 + } +} \ No newline at end of file diff --git a/649/TumorCenter_CD3_block12_x1_y7_patient649_0.json b/649/TumorCenter_CD3_block12_x1_y7_patient649_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bff72c6924cf4d7633adbb9fc12a5f851da3901c --- /dev/null +++ b/649/TumorCenter_CD3_block12_x1_y7_patient649_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3448.2, + "Centroid Y µm": 17265.9, + "Num Detections": 19264, + "Num Negative": 17844, + "Num Positive": 1420, + "Positive %": 7.371, + "Num Positive per mm^2": 685.15 + } +} \ No newline at end of file diff --git a/649/TumorCenter_CD3_block12_x2_y7_patient649_1.json b/649/TumorCenter_CD3_block12_x2_y7_patient649_1.json new file mode 100644 index 0000000000000000000000000000000000000000..47896452c40853e8d620c438b8538f20b92b1552 --- /dev/null +++ b/649/TumorCenter_CD3_block12_x2_y7_patient649_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 17340.8, + "Num Detections": 19511, + "Num Negative": 19000, + "Num Positive": 511, + "Positive %": 2.619, + "Num Positive per mm^2": 239.76 + } +} \ No newline at end of file diff --git a/649/TumorCenter_CD8_block12_x1_y7_patient649_0.json b/649/TumorCenter_CD8_block12_x1_y7_patient649_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6929ed127421138f3a4f9b49e0f8be4ea7ce2c96 --- /dev/null +++ b/649/TumorCenter_CD8_block12_x1_y7_patient649_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 26261.1, + "Num Detections": 15817, + "Num Negative": 15586, + "Num Positive": 231, + "Positive %": 1.46, + "Num Positive per mm^2": 116.3 + } +} \ No newline at end of file diff --git a/649/TumorCenter_CD8_block12_x2_y7_patient649_1.json b/649/TumorCenter_CD8_block12_x2_y7_patient649_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc3839a13e8fc0b7ac829a42c995f53bcdd2b566 --- /dev/null +++ b/649/TumorCenter_CD8_block12_x2_y7_patient649_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9245.1, + "Centroid Y µm": 26436.0, + "Num Detections": 16606, + "Num Negative": 16530, + "Num Positive": 76, + "Positive %": 0.4577, + "Num Positive per mm^2": 36.79 + } +} \ No newline at end of file diff --git a/649/history_text.txt b/649/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5132fdeca2a65ec0d3a83672cd3e4d480e78e013 --- /dev/null +++ b/649/history_text.txt @@ -0,0 +1 @@ +Patient with post-panendoscopy and PE for an unclear oropharyngeal tumor on the right. PE had been performed, histologically squamous cell carcinoma in situ. No invasive carcinoma. Now indication for re-evaluation and further therapy. Patient has been cleared up due to the tumor visible on MRI with deep infiltration and visible lymph node metastases up to flap coverage. \ No newline at end of file diff --git a/649/icd_codes.txt b/649/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/649/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/649/ops_codes.txt b/649/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9fda25818834d9f59a65cc15ad30cd513f549b7d --- /dev/null +++ b/649/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion einer Zungengrundtonsille: Durch Pharyngotomie[5-284.1 ] Lappenplastik an Haut und Unterhaut, Empfängerstelle: Freier Lappen mit mikrovaskulärer Anastomosierung: Sonstige Teile Kopf[5-905.04 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Biopsie ohne Inzision am Pharynx: Oropharynx: Tonsillen[1-422.01 R] Tonsillektomie (ohne Adenotomie): Partiell, transoral[5-281.5 ] \ No newline at end of file diff --git a/649/patient_clinical_data.json b/649/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..17d1219b57aa6c3b3011f92fddec12c4aa816d2d --- /dev/null +++ b/649/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2007, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/649/patient_pathological_data.json b/649/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f2d1cc355f6bfc9d56babbb1705aa6d7e003a412 --- /dev/null +++ b/649/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "649", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "TX", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/649/surgery_description.txt b/649/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4881764fc346ad49c563bb0c8d5cb21de4c7c330 --- /dev/null +++ b/649/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, PEG placement, Tracheotomy, Flap coverage (Radial) diff --git a/649/surgery_report.txt b/649/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..00d3a7bfb6dd425b6d45b8257764b847009af537 --- /dev/null +++ b/649/surgery_report.txt @@ -0,0 +1 @@ +First oropharyngoscopy/hypopharyngoscopy: The bulging tonsil on the right is visible, palpable induration in the pharyngeal wall. From....... Tonsil lobe up to the base of the tongue. Overall submucosally growing tumor. Incision is made in the area of the tonsillar lobe in the area of the induration. Several deep PEs here. These go to the frozen section. Invasive squamous cell carcinoma in the frozen section. Indication now given for further therapy. First PEG insertion: advancement of the endoscope into the stomach. There, after diaphanoscopy, problem-free insertion of a 9 mm stomach wall tube. Then sterile draping. Injection of a total of 10 ml xylocaine 1% with adrenaline. Tumor resection: Start enorally. The tumor is cut around at least all sides at a distance of approx. 1.5 cm, also towards the depth. Resection from the enoral side includes the base of the tongue almost to the middle, the entire tonsil lobe and large parts of the pharyngeal wall as well as the lateral wall of the oropharynx up to the transition to the posterior wall. In the hyoid region, the tumor has invaded the soft tissue here, including the external tongue muscles. It was therefore decided to proceed transorally at the same time. A modified radical neck dissection is therefore performed first: skin incision as for neck dissection, but slightly extended caudally in order to prepare a platysmal flap if necessary. Exposure of the anterior border of the sternocleidomastoid muscle. Dissection of the fat lymph node preparation. Exposure of the internal jugular vein, internal and external carotid artery, vagus nerve, hypoglossal nerve, accessorius nerve. Development of the dorsal neck preparation while sparing the branches of the cervical plexus and clearing out large parts of level V. Subsequent clearing out of the anterior neck preparation while exposing and preserving the superior thyroid artery and the hypoglossal nerve. Several right lymph node metastases were removed. Then dissection of the external carotid artery away from the pharyngeal wall. The external carotid artery is dissected cranially and caudally above the superior thyroid artery as it is directly adjacent to the part of the pharyngeal wall to be removed and several branches branch off in the direction of the tumor. The lingual artery is ligated and cut. Also the facial artery. The hypoglossal nerve is cut upwards. The entire pharyngeal wall is resected from the transoral or transcervical side to the hypopharyngeal entrance at the level of the superior cornu. All parts of the base of the tongue and the adjacent external tongue muscles are also resected. The submandibular gland can be preserved. The lingual nerve cannot be preserved. Marginal samples are now taken from the anterior soft palate to the glosso-alveolar junction and from the posterior palatal arch to the posterior pharyngeal wall, caudally from the base of the tongue and basally cranially from the area of the thyroid muscles and the adjacent fatty tissue and finally also from the soft tissue at the junction of the base of the tongue / hyoid bone / hypopharynx. These are sent for frozen section. In the Schenll section, all marginal samples are tumor-free. Now modified radical neck dissection on the left: This is performed in the same way as on the right side, exposing the structures already listed. Here, too, level II clearing and large sections of V. Here, too, the superior artery is dissected and preserved. Now mark a forearm flap on the left forearm corresponding to the defect size of approx. 10 x 7 cm. Curved skin incision from the elbow to the marked flap. Cut around the flap. Clamping of the radial artery. Oxygen saturation at 100 % for a prolonged period. Clamping of the radial artery, transection and closure using a puncture ligature. Lifting of the radial artery flap subfascially. Preservation of the main branch of the antebrachial cutaneous nerve. Dissection of the flap pedicle up to the elbow. Outlets are coagulated or closed by ligatures. In the elbow, the artery can be dissected and placed distal to the outlet of the interosseous artery, which is also shown. Closure by puncture ligation. ............. several outlets. Finally, exposure of a main vein. Deposition and ligation proximally. Irrigation of the vascular stumps with heparin. The entire wound area is now irrigated enorally and cervically with H2O2 and Ringer's solution. Careful hemostasis. The flap is inserted enorally through the defect. This can close the defect completely. The flap is successively sutured in place with Vicryl 3/0 single-button sutures. Complete closure. The flap pedicle is transferred from the right to the left side via a created tunnel. Here, the radial artery is sutured end-to-end to the superior thyroid artery with a 9/0 ethilon. The radial vein is sutured to the internal jugular vein using the end-to-side technique with Ethilon 9/0. TachoSil is applied to the anastomosis region. Repeated careful hemostasis and irrigation of the wound. Wound closure in layers with insertion of a Redon drain. The defect on the left forearm is covered with a full-thickness skin taken from the right groin. The full-thickness skin is thinned out before suturing. Several incisions are made to relieve pressure. The full-thickness skin can be sutured in well. The residual wound on the forearm is closed in layers. Groin is closed primarily with insertion of a Redon drain. Now tracheostoma creation: small Kocher collar incision, dissection through the subcutaneous tissue to the infrahyoid muscles. Splitting of the same. Exposure of the thyroid isthmus. Undercutting of the thyroid, clamping, severing and treatment with puncture ligatures. Finally, visualization of the trachea. Entering the 2nd/3rd intercartilaginous space. Creation of a Björk flap. Epithelization of the same. Insertion of a 9 mm tracheal cannula. Patient has received 2 x 3 g Unacid intraoperatively. Please continue this antibiotic treatment for 1 week. Feeding via PEG. After swallowing gruel on the 10th day, if necessary, diet build-up. Patient goes to the intensive care unit for postoperative monitoring. Overall, at least cT3 oropharyngeal carcinoma on the right from the tonsil lobe to the base of the tongue with soft tissue infiltration at the level of the hyoid bone. Lymphangiosis probable. Therefore discuss postoperative RCT. \ No newline at end of file diff --git a/650/InvasionFront_CD3_block10_x1_y6_patient650_0.json b/650/InvasionFront_CD3_block10_x1_y6_patient650_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ab7326fffcb61f277e536ce2564ab6d9fb17364 --- /dev/null +++ b/650/InvasionFront_CD3_block10_x1_y6_patient650_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 20064.4, + "Num Detections": 13182, + "Num Negative": 12796, + "Num Positive": 386, + "Positive %": 2.928, + "Num Positive per mm^2": 203.28 + } +} \ No newline at end of file diff --git a/650/InvasionFront_CD3_block10_x2_y6_patient650_1.json b/650/InvasionFront_CD3_block10_x2_y6_patient650_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2025d87f218bd8f2c488157a04501dd39d0c3f5b --- /dev/null +++ b/650/InvasionFront_CD3_block10_x2_y6_patient650_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8270.6, + "Centroid Y µm": 20239.3, + "Num Detections": 21761, + "Num Negative": 20505, + "Num Positive": 1256, + "Positive %": 5.772, + "Num Positive per mm^2": 514.56 + } +} \ No newline at end of file diff --git a/650/InvasionFront_CD8_block10_x1_y6_patient650_0.json b/650/InvasionFront_CD8_block10_x1_y6_patient650_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02e8efd4ac5dddfb000415edfd88832e0b101127 --- /dev/null +++ b/650/InvasionFront_CD8_block10_x1_y6_patient650_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5172.3, + "Centroid Y µm": 20888.9, + "Num Detections": 13358, + "Num Negative": 13196, + "Num Positive": 162, + "Positive %": 1.213, + "Num Positive per mm^2": 87.08 + } +} \ No newline at end of file diff --git a/650/InvasionFront_CD8_block10_x2_y6_patient650_1.json b/650/InvasionFront_CD8_block10_x2_y6_patient650_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4028126dff0990bb5a598609531ce4e77b13ad96 --- /dev/null +++ b/650/InvasionFront_CD8_block10_x2_y6_patient650_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7646.0, + "Centroid Y µm": 21038.9, + "Num Detections": 21584, + "Num Negative": 20586, + "Num Positive": 998, + "Positive %": 4.624, + "Num Positive per mm^2": 413.89 + } +} \ No newline at end of file diff --git a/650/TumorCenter_CD3_block10_x1_y6_patient650_0.json b/650/TumorCenter_CD3_block10_x1_y6_patient650_0.json new file mode 100644 index 0000000000000000000000000000000000000000..536ae08474f86dc478c45265261c24ba66591bd9 --- /dev/null +++ b/650/TumorCenter_CD3_block10_x1_y6_patient650_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 15017.0, + "Num Detections": 13139, + "Num Negative": 12597, + "Num Positive": 542, + "Positive %": 4.125, + "Num Positive per mm^2": 293.26 + } +} \ No newline at end of file diff --git a/650/TumorCenter_CD3_block10_x2_y6_patient650_1.json b/650/TumorCenter_CD3_block10_x2_y6_patient650_1.json new file mode 100644 index 0000000000000000000000000000000000000000..41f4fd23c4f92b0a7a3107c3e67a808a4fbee060 --- /dev/null +++ b/650/TumorCenter_CD3_block10_x2_y6_patient650_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9095.2, + "Centroid Y µm": 15013.7, + "Num Detections": 10827, + "Num Negative": 9844, + "Num Positive": 983, + "Positive %": 9.079, + "Num Positive per mm^2": 617.48 + } +} \ No newline at end of file diff --git a/650/TumorCenter_CD8_block10_x1_y6_patient650_0.json b/650/TumorCenter_CD8_block10_x1_y6_patient650_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f47ea3b4d112b7d6158ee105d0812e4b24112d6 --- /dev/null +++ b/650/TumorCenter_CD8_block10_x1_y6_patient650_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 15816.6, + "Num Detections": 16472, + "Num Negative": 16038, + "Num Positive": 434, + "Positive %": 2.635, + "Num Positive per mm^2": 192.69 + } +} \ No newline at end of file diff --git a/650/TumorCenter_CD8_block10_x2_y6_patient650_1.json b/650/TumorCenter_CD8_block10_x2_y6_patient650_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2e6c0a80ecd2277555a93eadea733db5ccc6c67 --- /dev/null +++ b/650/TumorCenter_CD8_block10_x2_y6_patient650_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 15741.7, + "Num Detections": 9607, + "Num Negative": 8588, + "Num Positive": 1019, + "Positive %": 10.61, + "Num Positive per mm^2": 755.92 + } +} \ No newline at end of file diff --git a/650/history_text.txt b/650/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..93726b0d333d82b9004647ec00eb626de99b2e81 --- /dev/null +++ b/650/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the alveolar ridge area on the right cT1, additionally confirmed vocal fold carcinoma of the right vocal fold (in situ carcinoma), following histological confirmation of oropharyngeal/hypopharyngeal carcinoma on the right. After lip biopsy on the right. \ No newline at end of file diff --git a/650/icd_codes.txt b/650/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..090e3947890f32b8a6f057cc9a0fa00c86efc3ed --- /dev/null +++ b/650/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Bösartige Neubildung Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Bösartige Neubildung des Alveolarkamms[C41.1 ] Bösartige Neubildung des Alveolarkamms[C41.1 ] Bösartige Neubildung der Glottis[C32.0 ] Bösartige Neubildung der Glottis[C32.0 ] \ No newline at end of file diff --git a/650/ops_codes.txt b/650/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7dd6442000df678a53ec4c8a8c643582dc46af64 --- /dev/null +++ b/650/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 4 Regionen[5-403.03 B] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 4 Regionen[5-403.03 B] Permanente Tracheostomie: Tracheotomie[5-312.0 ] Permanente Tracheostomie: Tracheotomie[5-312.0 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Ohne Rekonstruktion[5-295.00 ] Partielle Resektion des Pharynx [Pharynxteilresektion]: Transoral: Ohne Rekonstruktion[5-295.00 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Destruktion: Sonstige[5-292.3x ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Destruktion: Sonstige[5-292.3x ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Dekortikation einer Stimmlippe, mikrolaryngoskopisch[5-300.5 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Dekortikation einer Stimmlippe, mikrolaryngoskopisch[5-300.5 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Andere partielle Laryngektomie: Endoskopische Laserresektion[5-302.5 ] Andere partielle Laryngektomie: Endoskopische Laserresektion[5-302.5 ] Lasertechnik: CO2-Laser[5-985.1 ] Lasertechnik: CO2-Laser[5-985.1 ] \ No newline at end of file diff --git a/650/patient_clinical_data.json b/650/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d52d8de5d314e88f7bd315eb75e154e5bb772b91 --- /dev/null +++ b/650/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2010, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "chemotherapy", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/650/patient_pathological_data.json b/650/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6854f12c713135ea2c4cddfd8ff9eb36bd75ac0e --- /dev/null +++ b/650/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "650", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/650/surgery_description.txt b/650/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..951256d0f146af0b6efe62d6c0f0fe1e52a7109d --- /dev/null +++ b/650/surgery_description.txt @@ -0,0 +1 @@ +Laser resection of oropharyngeal/hypopharyngeal cancer on the left, Bilateral neck dissection, Tracheostomy, PEG placement, Endoscopy diff --git a/650/surgery_report.txt b/650/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c6b9655bc9b86c272bfaa0dd22fd49559cebb046 --- /dev/null +++ b/650/surgery_report.txt @@ -0,0 +1 @@ +Pharyngoscopy and laryngoscopy are now performed again: No significant changes to the previous findings. In the area of the lower lip on the left, a suspicious leukoplakia mass was found. This was removed superficially and sent in as a final marginal sample. Post-resection of in situ carcinoma of the vocal fold on the right using a CO2 laser: All of the remaining teeth in the anterior region are no longer completely fixed. Incisors and premolar tooth on the left appear decayed. Pin tooth on the right also somewhat loosened. Adjustment is made with the size C small water pipe. The epithelium is resected under visualization while preserving the vocalis muscle. The entire specimen is sent in marked with a thread. No further tumor infiltrates in the frozen section, so that there is an R situation here. Subsequent resection of the alveolar ridge carcinoma on the right side: The previously described cT1 tumor is resected on all sides with a safety margin of at least 0.5 cm to 1 cm, macroscopically clearly within the healthy tissue. This results in a defect in the anterior palatal arch and on the alveolar ridge, with periosteum remaining here. The preparation is sent in as a complete preparation for frozen section diagnostics. Infiltrates still present in the anterior region towards the floor of the mouth and posteriorly towards the palatal arch. Therefore, another resection of at least 5 mm and a marginal sample of approx. 2 mm in width is made semicircularly from the front and back. In the frozen section specimens this time still mild to moderate dysplasia, but no more carcinoma in situ. R0 resection therefore also in the alveolar ridge area. Laser resection of the oro/hypopharyngeal carcinoma on the right is now performed: the patient's adjustability is approximately suboptimal. During adjustment, the remaining premolar tooth on the left, which is decayed, is loosened and can be removed without difficulty. The carcinoma is then successively resected in a preparation with the CO2 laser cw, super pulse and 4 to 5 watts. The result is a resection of the lower tonsil pole of the lower lateral pharyngeal wall, whereby the resection extends to the middle to the beginning of the posterior hypopharyngeal wall and laterally over the base of the tongue and vallecula area into the supragottic area. There, a large part of the aryepiglottic fold is resected away, whereby the resection also extends into the supraglottic area up to the vicinity of the pocket fold. The entrance to the piriform sinus is resected caudally up to the middle of the piriform sinus. The resection is performed basally while preserving a muscle layer. The specimen is marked with sutures (long/long=caudal piriform sinus; long/short=medial aryepigl. Fold medial; short/short=pharyngeal wall medial using blue suture and green suture: short/short=base of tongue; short/long=pharyngeal wall lateral and long/long: pharyngeal wall cranial tonsil. In the frozen section, there are still in situ tumor infiltrates in the caudal area towards the piriform sinus. Therefore, a wide resection of an almost 1 cm wide strip from the piriform sinus caudally, extending over the postcricoid area to the arytenoid cartilage, is performed again using a laser. This is followed by another conventional resection of a strip of mucosa several mm wide. This mucosal strip is sent in again for a frozen section. Despite extensive resection, focal in situ infiltrates in the lateral area of the hypopharynx are still visible in the final marginal specimen. The resection extended into the tip of the hypopharynx. The arytenoid cartilage and postcricoid area in the paramedian right and left areas were well preserved mucosally; the mucosa was almost completely missing on the right side. Due to the extent and the fact that a total of 3 tumors are present and there is multicentric tumor growth, no further resection is performed here. Prior to tumor resection, a PEG was inserted into the stomach using a flexible esophagoscope. There, under visualization, insertion of a 9 mm abdominal wall tube in the typical manner without complications. Fix it to the abdominal wall. Then selective neck dissection on both sides: same procedure on both sides. First neck dissection on the right: skin incision in a typical manner along the sternocleidomastoid muscle. Subsequent exposure of the muscle, exposure of the omohyoid muscle, exposure of the digastric muscle. Exposure of the cervical vascular sheath, internal jugular vein, external/internal carotid artery, vagus nerve, accessorius nerve. Development of the dorsal neck preparation while preserving the cervical plexus. Subsequent development of the anterior neck preparation, exposing and preserving the hypoglossal nerve, superior thyroid artery and cervical nerve. Overall, level II to V were removed due to the multiple tumors. Neck dissection on the left side was performed in the same way. Here, after hemostasis, the wound was closed in layers with the insertion of a Redon drain. Then tracheostoma creation: small Kocher collar incision, dissection through the subcutaneous tissue to the infrahyoid musculature. Spreading of the same. Exposure of the thyroid isthmus. Undercutting of the thyroid gland, clamping and treatment with puncture ligatures. Subsequent exposure of the trachea. A small, visor-like Björk flap is created. This is epithelized in the typical manner. Subsequently reintubation and insertion of a size 8 tracheal cannula. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Total carcinoma in situ, vocal fold R0 situation, alveolar ridge carcinoma cT1-2, R0 situation and oropharyngeal/hypopharyngeal carcinoma involving the supraglottic region - total cT3-4. Due to the number of tumors and the microscopic tumor infiltration in the area of inconspicuous mucosa, it is assumed that the tumor is multicentric. In any case, postoperative radio-chemotherapy is indicated. Nutrition via the inserted PEG tube. After approx. 1 week, a diet can be started. Due to the preserved arytenoid cartilage, there may be a delay in relearning to swallow. \ No newline at end of file diff --git a/651/InvasionFront_CD3_block15_x3_y10_patient651_0.json b/651/InvasionFront_CD3_block15_x3_y10_patient651_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aee6344262e59d1b5e8207ddb551c71424b9e50f --- /dev/null +++ b/651/InvasionFront_CD3_block15_x3_y10_patient651_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 35056.4, + "Num Detections": 20523, + "Num Negative": 20232, + "Num Positive": 291, + "Positive %": 1.418, + "Num Positive per mm^2": 117.77 + } +} \ No newline at end of file diff --git a/651/InvasionFront_CD3_block15_x4_y10_patient651_1.json b/651/InvasionFront_CD3_block15_x4_y10_patient651_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e41d7e3e6be534617224478433021ebe2de1f408 --- /dev/null +++ b/651/InvasionFront_CD3_block15_x4_y10_patient651_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 34931.5, + "Num Detections": 23322, + "Num Negative": 22681, + "Num Positive": 641, + "Positive %": 2.748, + "Num Positive per mm^2": 252.42 + } +} \ No newline at end of file diff --git a/651/InvasionFront_CD8_block15_x3_y10_patient651_0.json b/651/InvasionFront_CD8_block15_x3_y10_patient651_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d105b71fe42db626708e55b9fb78d673f03b4f46 --- /dev/null +++ b/651/InvasionFront_CD8_block15_x3_y10_patient651_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11547.3, + "Centroid Y µm": 24554.0, + "Num Detections": 14095, + "Num Negative": 14087, + "Num Positive": 8, + "Positive %": 0.0568, + "Num Positive per mm^2": 4.05 + } +} \ No newline at end of file diff --git a/651/InvasionFront_CD8_block15_x4_y10_patient651_1.json b/651/InvasionFront_CD8_block15_x4_y10_patient651_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c87e20a0ae5f9d5fc565095e4d8b020a1ae4c7db --- /dev/null +++ b/651/InvasionFront_CD8_block15_x4_y10_patient651_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14145.6, + "Centroid Y µm": 24498.8, + "Num Detections": 15037, + "Num Negative": 14989, + "Num Positive": 48, + "Positive %": 0.3192, + "Num Positive per mm^2": 21.83 + } +} \ No newline at end of file diff --git a/651/TumorCenter_CD3_block15_x3_y10_patient651_0.json b/651/TumorCenter_CD3_block15_x3_y10_patient651_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1a919e8774bf8197ec6b8471304c89fea48d63e3 --- /dev/null +++ b/651/TumorCenter_CD3_block15_x3_y10_patient651_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 28459.9, + "Num Detections": 20233, + "Num Negative": 19388, + "Num Positive": 845, + "Positive %": 4.176, + "Num Positive per mm^2": 328.09 + } +} \ No newline at end of file diff --git a/651/TumorCenter_CD3_block15_x4_y10_patient651_1.json b/651/TumorCenter_CD3_block15_x4_y10_patient651_1.json new file mode 100644 index 0000000000000000000000000000000000000000..96f7c71282b33221473c3cdc2a5ccec82e83346c --- /dev/null +++ b/651/TumorCenter_CD3_block15_x4_y10_patient651_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 28484.9, + "Num Detections": 19643, + "Num Negative": 19255, + "Num Positive": 388, + "Positive %": 1.975, + "Num Positive per mm^2": 172.45 + } +} \ No newline at end of file diff --git a/651/TumorCenter_CD8_block15_x3_y10_patient651_0.json b/651/TumorCenter_CD8_block15_x3_y10_patient651_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3fc9c81ef949a8789caa7b122f262b3e37ae93c4 --- /dev/null +++ b/651/TumorCenter_CD8_block15_x3_y10_patient651_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 24961.8, + "Num Detections": 22400, + "Num Negative": 22218, + "Num Positive": 182, + "Positive %": 0.8125, + "Num Positive per mm^2": 71.19 + } +} \ No newline at end of file diff --git a/651/TumorCenter_CD8_block15_x4_y10_patient651_1.json b/651/TumorCenter_CD8_block15_x4_y10_patient651_1.json new file mode 100644 index 0000000000000000000000000000000000000000..12bfc4f239fab988769a76d32620651bd1a1e899 --- /dev/null +++ b/651/TumorCenter_CD8_block15_x4_y10_patient651_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16116.5, + "Centroid Y µm": 24961.8, + "Num Detections": 19183, + "Num Negative": 19137, + "Num Positive": 46, + "Positive %": 0.2398, + "Num Positive per mm^2": 20.33 + } +} \ No newline at end of file diff --git a/651/history_text.txt b/651/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..07a341cbc44cdbd389c97ae278eff321a2ce7ba9 --- /dev/null +++ b/651/history_text.txt @@ -0,0 +1 @@ +Mr. has a histologically confirmed cT2 c N0 glottic carcinoma of the left side with a clear infiltration in the anterior commissure and also a subglottic extension. The patient was therefore also informed about an external approach. \ No newline at end of file diff --git a/651/icd_codes.txt b/651/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d220406bb9f820a9488c92a1fdebe2fb59920ef7 --- /dev/null +++ b/651/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 ] \ No newline at end of file diff --git a/651/ops_codes.txt b/651/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..316eed08e0cb5ae35500cc9766828e9bcd00611c --- /dev/null +++ b/651/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Destruktion: Elektrokoagulation[5-300.30 ] Andere partielle Laryngektomie: Chordektomie durch Thyreotomie[5-302.2 ] Andere partielle Laryngektomie: Teilresektion, frontolateral (Leroux-Robert)[5-302.7 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 1 Region[5-403.00 L] \ No newline at end of file diff --git a/651/patient_clinical_data.json b/651/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9843365df643b783a7f339d29220fd3910f8a3cd --- /dev/null +++ b/651/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 62, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/651/patient_pathological_data.json b/651/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3f935818a6dcbbdb76e39c5686714f75357245bc --- /dev/null +++ b/651/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "651", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/651/surgery_description.txt b/651/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..13b469f0be501473e6f5ff4d4626aed07cc7832e --- /dev/null +++ b/651/surgery_description.txt @@ -0,0 +1 @@ +Initially laser resection, then partial resection (Leroux Robert), ND diff --git a/651/surgery_report.txt b/651/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a6fddaa25b6ae06376258a4e10db33883d8f2c3c --- /dev/null +++ b/651/surgery_report.txt @@ -0,0 +1 @@ +Preoperative loupe laryngoscopy showed regular vocal fold mobility on the left side. After anesthesia and intubation with the laser tube through the anesthesia, the first step was microlaryngoscopy: Here, the tumor described above was seen, partly exophytic, partly exulcerated, affecting the entire vocal fold and growing into the morgue sinus. Palpatorily quite coarse and growing into the anterior commissure, also a clearly subglottic growth of approx. 1 cm caudally. The upper part of the pocket folds is certainly well free, the arytenoid cartilage of the left side is also free. The left vocal fold does not appear to be affected. Therefore, after consultation with , a laser resection will now be attempted. The tumor is first reduced in size in its anterior region. However, it turned out that it was not possible to create a good overview in the anterior commissure area and that there was significant subglottic growth in this area, which also justified the classification cT2 in any case. Therefore, after consulting again, the decision was made to perform a partial laryngectomy from the outside. Now procedure for partial laryngeal resection via thyrotomy: Zigzag incision. Dissection through the subcutaneous tissue and platysma. Exposure of the prelaryngeal musculature. First spread the omohyoid muscle. Then identify the anterior edge of the thyroid cartilage. Two lymph nodes up to 1 cm in size are now identified in the area between the thyroid cartilage and the cricoid cartilage, which correspond to the Delphi lymph nodes. These are now resected in the sense of a selective level VI lymph node resection and sent separately for final histology. After exposing the perichondrium of the cartilage, the perichondrium is now slit paramedially on the right and then pushed to the left side with the Freer, and the thyroid cartilage is split with the wheel in the sense of a thyreotomy. Now open the inside of the larynx in the superior region. The right paramedian incision is also made at the glottic level. Now spread open the larynx with the retractor. An approx. 2 cm large tumor is revealed, which is now resected under direct vision. The inner side of the perichondrium is also removed in depth with the freer, the incision is extended caudally at the level of the cricoid cartilage and a large part of the pocket fold is resected cranially. Posteriorly, the resection includes the vocalis process of the arytenoid cartilage. The vocalis muscle on the left side is of course completely resected. Now turn to the right side. Here there is slightly irregular tissue in the most anterior area of the right vocal fold, which is why a very circumscribed resection is performed here. Now 4 quick incisions are made, once inferior and superior, once in the arytenoid area and then in the area of the right vocal fold, all of which are later found to be tumor-free. Now most careful hemostasis with bipolar coagulation and even after increasing the blood pressure to 145/90 there is no bleeding. Together with , a tracheostomy is now dispensed with. The Keel is now inserted after making 4 small drill holes with the Lindemann burr. Then readaptation of the cranial and caudal gaps of the keel using the perichondrium and connective tissue. Readaptation of the musculature, creation of a flap and two-layer wound closure. Intraoperative administration of 250 mg SDH and 600 mg Sobelin. Patient should be presented at the tumor conference and in any case undergo a control microlaryngoscopy with Keel removal in 8 weeks. \ No newline at end of file diff --git a/652/InvasionFront_CD3_block12_x1_y12_patient652_0.json b/652/InvasionFront_CD3_block12_x1_y12_patient652_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70954a51287efaccd2fa05e4254b3b4c71026361 --- /dev/null +++ b/652/InvasionFront_CD3_block12_x1_y12_patient652_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3098.4, + "Centroid Y µm": 33707.2, + "Num Detections": 18209, + "Num Negative": 15066, + "Num Positive": 3143, + "Positive %": 17.26, + "Num Positive per mm^2": 1679.6 + } +} \ No newline at end of file diff --git a/652/InvasionFront_CD3_block12_x2_y12_patient652_1.json b/652/InvasionFront_CD3_block12_x2_y12_patient652_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49e24e1392a3fda7b42c39918039f4b5f183a8eb --- /dev/null +++ b/652/InvasionFront_CD3_block12_x2_y12_patient652_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 33957.0, + "Num Detections": 19866, + "Num Negative": 17822, + "Num Positive": 2044, + "Positive %": 10.29, + "Num Positive per mm^2": 1045.8 + } +} \ No newline at end of file diff --git a/652/InvasionFront_CD8_block12_x1_y12_patient652_0.json b/652/InvasionFront_CD8_block12_x1_y12_patient652_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a8ed2b01f2c1a74038212f89835d88f685637a25 --- /dev/null +++ b/652/InvasionFront_CD8_block12_x1_y12_patient652_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5632.9, + "Centroid Y µm": 33591.1, + "Num Detections": 14782, + "Num Negative": 11540, + "Num Positive": 3242, + "Positive %": 21.93, + "Num Positive per mm^2": 2222.4 + } +} \ No newline at end of file diff --git a/652/InvasionFront_CD8_block12_x2_y12_patient652_1.json b/652/InvasionFront_CD8_block12_x2_y12_patient652_1.json new file mode 100644 index 0000000000000000000000000000000000000000..18704c438ca035a584e786d9ced291941c21dd73 --- /dev/null +++ b/652/InvasionFront_CD8_block12_x2_y12_patient652_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8195.7, + "Centroid Y µm": 33607.3, + "Num Detections": 14753, + "Num Negative": 11244, + "Num Positive": 3509, + "Positive %": 23.78, + "Num Positive per mm^2": 2326.6 + } +} \ No newline at end of file diff --git a/652/TumorCenter_CD3_block12_x1_y12_patient652_0.json b/652/TumorCenter_CD3_block12_x1_y12_patient652_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fb4859990b327649aad11d08f95a871197fd9657 --- /dev/null +++ b/652/TumorCenter_CD3_block12_x1_y12_patient652_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3298.3, + "Centroid Y µm": 29284.5, + "Num Detections": 17899, + "Num Negative": 11272, + "Num Positive": 6627, + "Positive %": 37.02, + "Num Positive per mm^2": 3391.0 + } +} \ No newline at end of file diff --git a/652/TumorCenter_CD3_block12_x2_y12_patient652_1.json b/652/TumorCenter_CD3_block12_x2_y12_patient652_1.json new file mode 100644 index 0000000000000000000000000000000000000000..880fc733a5b75753f9e9ba59023fdc6130f71e98 --- /dev/null +++ b/652/TumorCenter_CD3_block12_x2_y12_patient652_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 29384.4, + "Num Detections": 18940, + "Num Negative": 15020, + "Num Positive": 3920, + "Positive %": 20.7, + "Num Positive per mm^2": 2003.5 + } +} \ No newline at end of file diff --git a/652/TumorCenter_CD8_block12_x1_y12_patient652_0.json b/652/TumorCenter_CD8_block12_x1_y12_patient652_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c99d199679ac4bf2f21ff2913846cc5484cc9233 --- /dev/null +++ b/652/TumorCenter_CD8_block12_x1_y12_patient652_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5921.9, + "Centroid Y µm": 38229.8, + "Num Detections": 17333, + "Num Negative": 9309, + "Num Positive": 8024, + "Positive %": 46.29, + "Num Positive per mm^2": 4107.4 + } +} \ No newline at end of file diff --git a/652/TumorCenter_CD8_block12_x2_y12_patient652_1.json b/652/TumorCenter_CD8_block12_x2_y12_patient652_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6283a86bdde242ebb369e8be8fc8e1e11ae93dc --- /dev/null +++ b/652/TumorCenter_CD8_block12_x2_y12_patient652_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8445.5, + "Centroid Y µm": 38479.6, + "Num Detections": 18007, + "Num Negative": 15534, + "Num Positive": 2473, + "Positive %": 13.73, + "Num Positive per mm^2": 1267.5 + } +} \ No newline at end of file diff --git a/652/history_text.txt b/652/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/652/icd_codes.txt b/652/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/652/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/652/ops_codes.txt b/652/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..31539d0d4a78df8fa806113a88f222dc753a43cf --- /dev/null +++ b/652/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/652/patient_clinical_data.json b/652/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..56b17f0761c94ef48f769a5e84111d201d89ac09 --- /dev/null +++ b/652/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/652/patient_pathological_data.json b/652/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..77c267c6be1936e81ca3c5c9bc3a643077f22304 --- /dev/null +++ b/652/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "652", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Lymphoepithelial", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/652/surgery_description.txt b/652/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce4dbb7d860e176ba7dd2db8201d6d56f0e517a1 --- /dev/null +++ b/652/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Tracheotomy diff --git a/652/surgery_report.txt b/652/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed8f5aa32b396fcb9a143e170c528a2217973be9 --- /dev/null +++ b/652/surgery_report.txt @@ -0,0 +1 @@ +Tracheoscopy is performed before the start of the procedure or before intubation. To do this, adjust the entrance to the larynx with the laryngoscope. Insert the 0° scope. The right arytenoid cusp is clearly swollen, oedematous, very narrow glottic gap. The subglottic space, the trachea up to the bifurcation and the visible main bronchi are unremarkable. After intubation, an esophagoscopy is performed and the flexible esophagoscope is inserted into the stomach. Conditions there are unremarkable. No evidence of a tumor in the area of the cardia even when looking backwards. Diaphanoscopy, insertion of the PEG using the thread pull-through method. The esophagus is usually checked again when the endoscope is withdrawn. No evidence of a second tumor. Problem-free PEG placement. Pharyngoscopy: Adjustment of the small bore tube. As described above, the exophytic growing tumor can be seen in the area of the right aryepiglottic fold merging with the upper piriform sinus. The rest of the right piriform sinus and the entire left piriform sinus and the postcricoid region are unremarkable. The esophageal entrance is clear. The base of the tongue, epiglottis and valecula are unremarkable. In addition, microlaryngoscopy only shows edematous conditions on the right side in the region of the laryngeal head. This is probably submucosal tumor growth. The vocal folds are, as far as can be seen, unremarkable. The supraglottic region on the left is also unremarkable. The base of the tongue is soft on palpation. After completion of the panendoscopy, detailed consultation with the anesthesiologist regarding the further procedure. Preparation for laryngectomy. The tumor is resectable. Perioperative administration of Unacid. Continue this postoperatively. Skin disinfection, infiltration anesthesia for the apron flap. Neck dissection on the right side first. Make an incision from the earlobe to the supraclavicular area. Expose the sternocleidomastoid muscle and cut off the external jugular vein. Exposure of the internal jugular vein, facial vein, vagus nerve, accessorius nerve, digasticus muscle, posterior vena cava. Now dissection of the posterior part of the neck from the accessorius area to the supraclavicular area. Overall very difficult dissection conditions due to the very voluminous conditions. At least two suspicious nodes on this side, especially in the vein angle. Further dissection in the direction of the venous angle. Exposure of the hypoglossal nerve, the cervical nerve. This will be cut later. Expose the external, internal and common carotid artery and the superior laryngeal artery. This is stitched. Now complete the anterior neck preparation, including the capsule of the submandibular gland. Separate the common carotid artery, the thyroid gland and the larynx. Now perform the neck dissection on the left side. Also make a skin incision from infraauricular to supraclavicular. Expose the sternocleidomastoid muscle, cut off the external jugular vein. Exposure of the internal jugular vein, the accessorius nerve and the vagus nerve. Dissection of the digasticus muscle, posterior venter and dissection of the posterior neck preparation from cranial to caudal to supraclavicular on the left side. After cutting through the caudal end, repositioning to prevent a fistula. Now expose the common, external and internal carotid artery. Separation and ligation of the superior vein. Exposure of the hyperglossal nerve, completion of the anterior neck preparation including the capsule of the submandibular gland. Very difficult preparation conditions on this side due to the voluminous conditions. Complete the neck preparation on the left side. Now join the two neck incisions and dissect an apron flap cranially up to the hyoid. Expose the laryngeal skeleton on both sides and free preparation of the piriform sinus on both sides, detachment from the thyroid cartilage. Now cut the infrahyoid muscles and enter the pharynx just above the epiglottis. Grasp the epiglottis and resect the mucosa in the area of the aryepiglottic fold on both sides up to the intraaryhaenoid region. The tumor is located on the right side. Here, the piriform sinus is partially incised and the post-crecoid region is then reached again from the other side, from the caudal side. Clinically, the resection is performed in sano. Push the postcrecoid region caudally. Exposure of the cricoid cartilage, separation of the larynx from the pharynx. Sever the connection between the larynx and trachea. The laryngectomy specimen now removed is sent for definitive histology. Representative marginal samples are taken. These are described as mild dysplasia in the frozen section. No carcinoma in situ, no invasive carcinoma. A Provox prosthesis is then placed. This was relatively successful with good visibility. Somewhat difficult threading in the area of the trachea. In the end, however, the Provox prosthesis fits well. Extensive hemostasis with H2O2 and bipolar coagulation. Irrigation with H2O2 solution and Ringer's solution. No more bleeding. Now perform the pharyngeal suture, initially caudally and cranially and then also in the middle section of the pharynx. Complete closure. Repeat several times and three-layer wound closure in the area of the pharynx. Reapproximation of the infrahoidal musculature in the area of the hyoid bone. Suture the trachea as a tracheostoma into the skin flap and supraclavicularly. Now clean the neck again on both sides, rinse with H2O2 and Ringer's solution. No bleeding. Insertion of a Redon drain on both sides. Subcutaneous suture, skin suture and wound dressing. A feeding tube was inserted preoperatively. This should serve as a nasogastric tube for splinting for a few days. Insertion of a tracheal cannula, which is fixed with stitches. Completion of the procedure. No bleeding, no other special features. Pass on antibiotics postoperatively. Finally, another detailed consultation with the anesthetist. The patient is transferred to the intensive care unit for monitoring. Overall difficult preparation conditions due to the very voluminous conditions. Waiting for the definitive histology, then presentation at the tumor conference. \ No newline at end of file diff --git a/653/InvasionFront_CD3_block23_x1_y1_patient653_0.json b/653/InvasionFront_CD3_block23_x1_y1_patient653_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f31d535ba546bbad30f02fade697628d79bfe6b0 --- /dev/null +++ b/653/InvasionFront_CD3_block23_x1_y1_patient653_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11611.6, + "Centroid Y µm": 20991.1, + "Num Detections": 13551, + "Num Negative": 13465, + "Num Positive": 86, + "Positive %": 0.6346, + "Num Positive per mm^2": 36.29 + } +} \ No newline at end of file diff --git a/653/InvasionFront_CD3_block23_x2_y1_patient653_1.json b/653/InvasionFront_CD3_block23_x2_y1_patient653_1.json new file mode 100644 index 0000000000000000000000000000000000000000..694da6e43d3ff38deccd1de98525c87d334e79a7 --- /dev/null +++ b/653/InvasionFront_CD3_block23_x2_y1_patient653_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13859.9, + "Centroid Y µm": 20531.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/653/InvasionFront_CD8_block23_x1_y1_patient653_0.json b/653/InvasionFront_CD8_block23_x1_y1_patient653_0.json new file mode 100644 index 0000000000000000000000000000000000000000..58237362a450950ecc361c4ef7998293bc324026 --- /dev/null +++ b/653/InvasionFront_CD8_block23_x1_y1_patient653_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11088.9, + "Centroid Y µm": 10717.2, + "Num Detections": 19882, + "Num Negative": 19855, + "Num Positive": 27, + "Positive %": 0.1358, + "Num Positive per mm^2": 11.42 + } +} \ No newline at end of file diff --git a/653/InvasionFront_CD8_block23_x2_y1_patient653_1.json b/653/InvasionFront_CD8_block23_x2_y1_patient653_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9d9b2322583db7ff6b795fddace287b7cef28207 --- /dev/null +++ b/653/InvasionFront_CD8_block23_x2_y1_patient653_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13418.1, + "Centroid Y µm": 10499.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/653/TumorCenter_CD3_block23_x2_y1_patient653_0.json b/653/TumorCenter_CD3_block23_x2_y1_patient653_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6c971e6fe1f9ba77f6e6134d12c4095f973a0472 --- /dev/null +++ b/653/TumorCenter_CD3_block23_x2_y1_patient653_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10513.8, + "Centroid Y µm": 20379.0, + "Num Detections": 23121, + "Num Negative": 22747, + "Num Positive": 374, + "Positive %": 1.618, + "Num Positive per mm^2": 155.93 + } +} \ No newline at end of file diff --git a/653/TumorCenter_CD8_block23_x1_y1_patient653_0.json b/653/TumorCenter_CD8_block23_x1_y1_patient653_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8f2e0815a64ab4e50f7e71e591fad0aad42c41f0 --- /dev/null +++ b/653/TumorCenter_CD8_block23_x1_y1_patient653_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 2673.6, + "Centroid Y µm": 2323.8, + "Num Detections": 22683, + "Num Negative": 22560, + "Num Positive": 123, + "Positive %": 0.5423, + "Num Positive per mm^2": 51.56 + } +} \ No newline at end of file diff --git a/653/TumorCenter_CD8_block23_x2_y1_patient653_1.json b/653/TumorCenter_CD8_block23_x2_y1_patient653_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8a8804f02e2665271e4a13c429eff42c6b1d05dc --- /dev/null +++ b/653/TumorCenter_CD8_block23_x2_y1_patient653_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5011.0, + "Centroid Y µm": 2755.2, + "Num Detections": 8385, + "Num Negative": 8361, + "Num Positive": 24, + "Positive %": 0.2862, + "Num Positive per mm^2": 28.98 + } +} \ No newline at end of file diff --git a/653/history_text.txt b/653/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b7c1fd728af2dabd8e3d6c51ff935430acf29ba4 --- /dev/null +++ b/653/history_text.txt @@ -0,0 +1 @@ +The patient has a histologically confirmed carcinoma of the right-sided larynx with CN-....... status on the right. \ No newline at end of file diff --git a/653/icd_codes.txt b/653/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b8254737ad4f233838248e31c508417f0c852314 --- /dev/null +++ b/653/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] Lymphknotenvergrößerung, nicht näher bezeichnet[R59.9 ] \ No newline at end of file diff --git a/653/ops_codes.txt b/653/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..990ad677b66ac82cccb2cde03ed111f67961721c --- /dev/null +++ b/653/ops_codes.txt @@ -0,0 +1 @@ +Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] Andere partielle Laryngektomie: Endoskopische Laserresektion[5-302.5 ] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/653/patient_clinical_data.json b/653/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2ce3e50546f52fb1ca92da50dd711723f3a49cdb --- /dev/null +++ b/653/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 65, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 70, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + docetaxel", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/653/patient_pathological_data.json b/653/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..352a15c2e9129586f7a6c11a005b52ebcd4a2908 --- /dev/null +++ b/653/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "653", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/653/surgery_description.txt b/653/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..006b02a0de733efdd506e1816934a263841ce6b2 --- /dev/null +++ b/653/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy diff --git a/653/surgery_report.txt b/653/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..430c137dedc46a1fc0ff49611d8ba895c2e1e85f --- /dev/null +++ b/653/surgery_report.txt @@ -0,0 +1 @@ +After intubation, initial inspection of the tumor by microlaryngoscopy: It is apparent that the right vocal fold has been consumed by the tumor and that this process extends to the anterior commissure. As confirmed by loupe laryngoscopy, the function of this is also restricted. Furthermore, it can be seen that the tumor extends from the dorsal end of the right vocal fold cranially, i.e. supraglottically, towards the arytenoid hump, which has become distended and edematous. The pocket fold on the right side is raised but not indurated. The left-sided glottis is free. Subglottic also free. Otherwise, no noticeable tumor growth postcricoidally or in either piriform sinus. Now start with the laser resection: Adjustment of the tumor, first of all of the anterior commissure with the Kleinsasser B-tube and cutting around the anterior commissure, starting at the very anterior left vocal fold margin, then transfer to the anterior commissure through Broyl's tendon and detachment of the right tumorous vocal fold from the anterior commissure and from the subglottic slope. Now reposition and enter with the spread laryngoscope and then remove the right-sided pocket fold in order to obtain a view. It turns out that this is a good idea, as the tumor continues to move in the direction of the morgue sinus. The tumor is now sharply incised with the laser beam at a power of initially 5 and later 7 watts. The tumor is removed in toto, continuing from the loosened anterior commissure to the dorsal side. Now remove the tumor portion of the right vocal fold in toto and remove it. The right arytenoid area and right supraglottis are then repositioned. The tumor is then first resected macroscopically far into the healthy tissue using a laser beam. The vocal process of the arytenoid cartilage is resected. Subsequent inspection. It becomes apparent that there are still clinical tumor remnants in the area of the arytenoid cartilage, so that the arytenoid cartilage is now resected with the laser beam. Now clinical absence of tumor and hemostasis with the monopolar and by means of supratupfer. Marginal samples were taken from the anterior commissure, from the right former pocket fold and from the right subglottic plane, also from the former right glottic area and from the right arytenoid area. In the course of the operation, these marginal samples were all found to be tumor-free in the frozen section, but it should be noted that no epithelium was visible in the frozen section in the area of the right glottis and the right supraglottis. Intermediate demonstration of findings on and . Now repositioning for neck dissection, first on the right: injection of 10 ml xylocaine with added adrenaline in the area of the front edge of the sternocleidomastoid on the right after abjoding. Followed by a curved skin incision, cutting through the subcutaneous tissue and the platysma. Expose the anterior edge of the sternocleidomastoid muscle, the accessorius nerve, the internal jugular vein and the vagus nerve after cutting through the omohyoid muscle. The posterior neck preparation is then detached from the plexus branches and removed after release from the upper accessorius triangle. The accessorius nerve is preserved. Now complete the anterior neck, including resection of the capsule of the submandibular gland and exposure of the hypoglossal nerve. The vagus nerve and the common carotid artery remain untouched. Then hemostasis with bipolar forceps, hydrogen and Ringer irrigation. Insertion of a 10-gauge Redon drain and two-layer wound closure. Repositioning for neck dissection on the left side: Here also instillation of 10 ml xylocaine with adrenaline and curved skin incision in the area of the anterior edge of the sternocleidomastoid. Exposure of the anterior border of the sternocleidomastoid, the accessorius nerve, the digaster muscle, the omohyoid muscle, the internal jugular vein, the vagus nerve and the common carotid artery. Removal of the posterior neck preparation while sparing the plexus branches. Bipolar hemostasis. Completion of the anterior neck dissection, including the submandibular gland capsule and exposure of the hypoglossal nerve. The superior thyroid vein is ligated. Now repeat the inspection. The accessorius nerve is also preserved here without any problems. Now hemostasis again, hydrogen and Ringer irrigation and, after renewed hemostasis, insertion of a 10-gauge Redon drain. Two-layer wound closure here too. Now tracheostomy in the usual manner. Modified Kocher collar incision, separation of the platysma, the subcutaneous tissue and the prelaryngeal musculature. Exposure of the cricoid cartilage and undermining of the thyroid gland, transection of the isthmus and insertion between the 2nd and 3rd tracheal cartilage. Creation of a Björk flap and an epithelialized tracheostoma without complications. Insertion of an 8-gauge cannula and completion of the procedure without complications. Both the tumor specimens and the cervical lymph node specimens are sent for histological examination. \ No newline at end of file diff --git a/654/InvasionFront_CD3_block16_x5_y11_patient654_0.json b/654/InvasionFront_CD3_block16_x5_y11_patient654_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1b2e44a8f2d4d25eb8f6029fa86ff265b775ef89 --- /dev/null +++ b/654/InvasionFront_CD3_block16_x5_y11_patient654_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16491.3, + "Centroid Y µm": 31783.2, + "Num Detections": 15628, + "Num Negative": 13818, + "Num Positive": 1810, + "Positive %": 11.58, + "Num Positive per mm^2": 1054.1 + } +} \ No newline at end of file diff --git a/654/InvasionFront_CD3_block16_x6_y11_patient654_1.json b/654/InvasionFront_CD3_block16_x6_y11_patient654_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c4301ec1b3536290bc6f4071dd792466fae2d64 --- /dev/null +++ b/654/InvasionFront_CD3_block16_x6_y11_patient654_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 31808.2, + "Num Detections": 20343, + "Num Negative": 18433, + "Num Positive": 1910, + "Positive %": 9.389, + "Num Positive per mm^2": 884.74 + } +} \ No newline at end of file diff --git a/654/InvasionFront_CD8_block16_x5_y11_patient654_0.json b/654/InvasionFront_CD8_block16_x5_y11_patient654_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fb11120d23ade95fbd60a4cba79422009e58b33c --- /dev/null +++ b/654/InvasionFront_CD8_block16_x5_y11_patient654_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15481.5, + "Centroid Y µm": 26867.5, + "Num Detections": 5675, + "Num Negative": 5416, + "Num Positive": 259, + "Positive %": 4.564, + "Num Positive per mm^2": 318.81 + } +} \ No newline at end of file diff --git a/654/InvasionFront_CD8_block16_x6_y11_patient654_1.json b/654/InvasionFront_CD8_block16_x6_y11_patient654_1.json new file mode 100644 index 0000000000000000000000000000000000000000..260188770d43a3c8f27d28233c38803b8dec8920 --- /dev/null +++ b/654/InvasionFront_CD8_block16_x6_y11_patient654_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18029.4, + "Centroid Y µm": 26899.9, + "Num Detections": 17115, + "Num Negative": 16607, + "Num Positive": 508, + "Positive %": 2.968, + "Num Positive per mm^2": 243.51 + } +} \ No newline at end of file diff --git a/654/TumorCenter_CD3_block16_x5_y12_patient654_0.json b/654/TumorCenter_CD3_block16_x5_y12_patient654_0.json new file mode 100644 index 0000000000000000000000000000000000000000..68d1eff9785bf10a3bab79b99fc4defc1e31a7f1 --- /dev/null +++ b/654/TumorCenter_CD3_block16_x5_y12_patient654_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15791.6, + "Centroid Y µm": 31108.5, + "Num Detections": 21219, + "Num Negative": 17141, + "Num Positive": 4078, + "Positive %": 19.22, + "Num Positive per mm^2": 1657.3 + } +} \ No newline at end of file diff --git a/654/TumorCenter_CD3_block16_x6_y12_patient654_1.json b/654/TumorCenter_CD3_block16_x6_y12_patient654_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cf0af8b75f8b9ee2cb08205d1937692406f630aa --- /dev/null +++ b/654/TumorCenter_CD3_block16_x6_y12_patient654_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18640.1, + "Centroid Y µm": 31433.4, + "Num Detections": 23350, + "Num Negative": 21250, + "Num Positive": 2100, + "Positive %": 8.994, + "Num Positive per mm^2": 834.35 + } +} \ No newline at end of file diff --git a/654/TumorCenter_CD8_block16_x5_y11_patient654_0.json b/654/TumorCenter_CD8_block16_x5_y11_patient654_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ecd21faadfb2a70867ebacd74cb6c7c70365d2ae --- /dev/null +++ b/654/TumorCenter_CD8_block16_x5_y11_patient654_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 27935.2, + "Num Detections": 10044, + "Num Negative": 9680, + "Num Positive": 364, + "Positive %": 3.624, + "Num Positive per mm^2": 228.23 + } +} \ No newline at end of file diff --git a/654/TumorCenter_CD8_block16_x6_y11_patient654_1.json b/654/TumorCenter_CD8_block16_x6_y11_patient654_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0700905b45b9d439dbebd633d584ec88d0faa4a2 --- /dev/null +++ b/654/TumorCenter_CD8_block16_x6_y11_patient654_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 27985.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/654/history_text.txt b/654/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..881a76732c5a6d23af6b4ddbd5ac6f2cd4491f8f --- /dev/null +++ b/654/history_text.txt @@ -0,0 +1 @@ +A few weeks ago, a large progressive mass in the area of the left middle third of the tongue. Clinically macroscopically highly suspected malignancy. In the preoperative ultrasound V.a. cN0 neck status. In the noxenanamnesis approx. 75 py. Due to the symptoms and clinical findings as well as the positive noxae history, there is now an indication for panendoscopy and excisional biopsy in the area of the left tongue. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/654/icd_codes.txt b/654/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a73e9d750abe46d2b0f4408a640e695a05830c14 --- /dev/null +++ b/654/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung des seitlichen Zungenrandes[D37.0 ] \ No newline at end of file diff --git a/654/ops_codes.txt b/654/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..111c328c4ee41f5009c3456ab1e704fc2c06318f --- /dev/null +++ b/654/ops_codes.txt @@ -0,0 +1 @@ +Zungentumorexzision[5-250.2 ] Intraoperative diagnostische Tracheoskopie[1-690.1 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Pharyngoskopie direkt[1-611.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Diagnostische Laryngoskopie direkt[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Biopsie ohne Inzision Glottis[1-421.1 ] \ No newline at end of file diff --git a/654/patient_clinical_data.json b/654/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b35cfb70911e30400a7ffecf3b3ce3075a9d0ee7 --- /dev/null +++ b/654/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/654/patient_pathological_data.json b/654/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..821244536200e4801e8dc07f167239f5cf99de2a --- /dev/null +++ b/654/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "654", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/654/surgery_description.txt b/654/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ce7c1a4b8f298bf759ac922b90fad68d5f7da059 --- /dev/null +++ b/654/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy of tongue edge on the left, Panendoscopy, Ablation of leukoplakia on the right diff --git a/654/surgery_report.txt b/654/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ca6e0753b47b0fb8eb42dd841bce92d26e3df448 --- /dev/null +++ b/654/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues, rigid tracheoscopy is performed. Problem-free passage of the glottis and entry into the endotracheal cavity. The mucosal conditions are unremarkable on all sides up to the tracheal bifurcation. Subsequent problem-free intubation by the surgeon. Start with esophagogastroscopy: insertion of the endoscope under visualization and constant air insufflation into the stomach. This reveals a typical gastric mucosal relief with no evidence of a tumor. However, the gastric mucosa appears erosively altered on all sides. However, an ulcer cannot be visualized. Subsequently, inversion and inspection of the gastroesophageal junction. This also shows erosive changes in the mucosa, but no evidence of a tumor. Subsequently, desufflation and slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. There is also no evidence of malignancy in the area of the esophagus. The surgeon then repositions the patient. Insertion of the mouth guard and insertion with the Kleinsasser B-tube. Adjustment of the endolarynx. In the area of the right vocal fold, there is an extensive leukoplakic mucosal change in the middle and anterior third. Adjustment of the endolarynx with the aid of support autoscopy and the surgical microscope. Subsequent removal of the leukoplakic change in toto under microlaryngoscopic control. Hemostasis by insertion of a suprarenin-impregnated swab. Subsequent inspection of the posterior commissure. This also appears unremarkable. Enter the piriform sinus on the right and left. This is lined on both sides by smooth mucosa and can be freely unfolded up to the tip of the piriform sinus. There is no evidence of a tumor either postcricoidally or in the area of the esophageal entrance. Subsequent inspection of the oropharynx and the oral cavity. In the area of the middle third of the left edge of the tongue, the exophytic mass described above is visible. This has a roundish configuration and grows exophytically. Posteriorly, the growth tends to become very superficial. Palpatorily, only the exophytic growing part infiltrates into the depth. The resection margins are then marked with an electric needle. Then excision biopsy in the sense of a partial tongue resection. This is done both with the electric needle in the superficial parts and with the pointed scissors and bipolar coagulation in the deeper sections. The tumor is removed clinically and macroscopically well within the healthy tissue. The tumor is thread-marked for definitive histology. A definitive margin sample is then taken in the area of the cranial resection margin and the anterior part is marked. Subsequently, extensive bipolar coagulation. If the wound bed is dry, adaptation of the resection margins with Vicryl 2/0 using the back-stitch technique. Intraoperative demonstration of the findings on . Completion of the operation without complications. Conclusion: V.a. cT1 cN0 tongue margin carcinoma on the left. Clinical macroscopic R0 resection. 1. depending on the definitive histologic findings, a neck dissection on the left side should be discussed. 2. removal of a leukoplakia in the area of the anterior and middle third of the right vocal fold. 3. erosive gastritis as part of the esophagogastroscopy. Postoperative internal assessment recommended and initiation of treatment with proton pump inhibitors. \ No newline at end of file diff --git a/655/InvasionFront_CD3_block20_x1_y4_patient655_0.json b/655/InvasionFront_CD3_block20_x1_y4_patient655_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1334758e54272f8ee94301f60a4439512a59186c --- /dev/null +++ b/655/InvasionFront_CD3_block20_x1_y4_patient655_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5497.1, + "Centroid Y µm": 9495.0, + "Num Detections": 15199, + "Num Negative": 12638, + "Num Positive": 2561, + "Positive %": 16.85, + "Num Positive per mm^2": 1357.8 + } +} \ No newline at end of file diff --git a/655/InvasionFront_CD3_block20_x2_y4_patient655_1.json b/655/InvasionFront_CD3_block20_x2_y4_patient655_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd8cfc6d5a3cfab950f6acc5ea2fecd48c2ecba4 --- /dev/null +++ b/655/InvasionFront_CD3_block20_x2_y4_patient655_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7795.9, + "Centroid Y µm": 9669.9, + "Num Detections": 17208, + "Num Negative": 14840, + "Num Positive": 2368, + "Positive %": 13.76, + "Num Positive per mm^2": 1211.9 + } +} \ No newline at end of file diff --git a/655/InvasionFront_CD8_block20_x1_y4_patient655_0.json b/655/InvasionFront_CD8_block20_x1_y4_patient655_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6faebecef58e2f91753a095f78f9fb571272522 --- /dev/null +++ b/655/InvasionFront_CD8_block20_x1_y4_patient655_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4197.8, + "Centroid Y µm": 10669.4, + "Num Detections": 13977, + "Num Negative": 11448, + "Num Positive": 2529, + "Positive %": 18.09, + "Num Positive per mm^2": 1453.1 + } +} \ No newline at end of file diff --git a/655/InvasionFront_CD8_block20_x2_y4_patient655_1.json b/655/InvasionFront_CD8_block20_x2_y4_patient655_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e20ad932da089b0b02727597d71a58dfe701c6e1 --- /dev/null +++ b/655/InvasionFront_CD8_block20_x2_y4_patient655_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6446.6, + "Centroid Y µm": 10469.5, + "Num Detections": 16795, + "Num Negative": 12458, + "Num Positive": 4337, + "Positive %": 25.82, + "Num Positive per mm^2": 2149.6 + } +} \ No newline at end of file diff --git a/655/TumorCenter_CD3_block20_x1_y4_patient655_0.json b/655/TumorCenter_CD3_block20_x1_y4_patient655_0.json new file mode 100644 index 0000000000000000000000000000000000000000..47dceeaae77056f7cb383ec3e88fc51cbbc0fdcb --- /dev/null +++ b/655/TumorCenter_CD3_block20_x1_y4_patient655_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3975.3, + "Centroid Y µm": 9326.7, + "Num Detections": 15668, + "Num Negative": 13637, + "Num Positive": 2031, + "Positive %": 12.96, + "Num Positive per mm^2": 1017.6 + } +} \ No newline at end of file diff --git a/655/TumorCenter_CD3_block20_x2_y4_patient655_1.json b/655/TumorCenter_CD3_block20_x2_y4_patient655_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6771588659a799520be40acccf43d09f87d2cbdd --- /dev/null +++ b/655/TumorCenter_CD3_block20_x2_y4_patient655_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6245.0, + "Centroid Y µm": 9437.8, + "Num Detections": 13860, + "Num Negative": 12346, + "Num Positive": 1514, + "Positive %": 10.92, + "Num Positive per mm^2": 871.5 + } +} \ No newline at end of file diff --git a/655/TumorCenter_CD8_block20_x1_y4_patient655_0.json b/655/TumorCenter_CD8_block20_x1_y4_patient655_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6223730a2d8ab32d0a78c2681350379774f1fa11 --- /dev/null +++ b/655/TumorCenter_CD8_block20_x1_y4_patient655_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 10269.6, + "Num Detections": 14190, + "Num Negative": 10018, + "Num Positive": 4172, + "Positive %": 29.4, + "Num Positive per mm^2": 2352.8 + } +} \ No newline at end of file diff --git a/655/TumorCenter_CD8_block20_x2_y4_patient655_1.json b/655/TumorCenter_CD8_block20_x2_y4_patient655_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9571676c096c839737ef842c17511970b32d85c3 --- /dev/null +++ b/655/TumorCenter_CD8_block20_x2_y4_patient655_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5622.0, + "Centroid Y µm": 10144.6, + "Num Detections": 13577, + "Num Negative": 9379, + "Num Positive": 4198, + "Positive %": 30.92, + "Num Positive per mm^2": 2380.2 + } +} \ No newline at end of file diff --git a/655/history_text.txt b/655/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..68a719564784fd85442d421fcbdead47b0ef5456 --- /dev/null +++ b/655/history_text.txt @@ -0,0 +1 @@ +The patient has had odynophagia, dysphonia and dyspnea on exertion since <2014>. In the panendoscopy of <2015> a tumor debulking was performed, so that the patient no longer had dyspnea. Clinically, there is vocal fold fixation. \ No newline at end of file diff --git a/655/icd_codes.txt b/655/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..11412121af0182427c1dcfec71dd5b017807ae5e --- /dev/null +++ b/655/icd_codes.txt @@ -0,0 +1 @@ +Subglottisches Karzinom[C32.2 L] \ No newline at end of file diff --git a/655/ops_codes.txt b/655/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a56a6ecd3835c8c8cc60486dac6736180bf9061c --- /dev/null +++ b/655/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie ohne Rekonstruktion[5-303.00 ] Partielle Resektion des Pharynx [Pharynxteilresektion] durch Pharyngotomie ohne Rekonstruktion[5-295.10 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Anlage ösophagotracheale Fistel[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte Hypopharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/655/patient_clinical_data.json b/655/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..177fa1ed0a6847c508435c796938b963f6979533 --- /dev/null +++ b/655/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 77, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 14, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/655/patient_pathological_data.json b/655/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..39db319098c3529fb71d2b7d0a705c80cc9ec5a8 --- /dev/null +++ b/655/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "655", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 32, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/655/surgery_description.txt b/655/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ff16283bd77c2e0f0c2d3452beb6b04a1196cdf --- /dev/null +++ b/655/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, Panendoscopy, PEG placement; Tumor debulking diff --git a/655/surgery_report.txt b/655/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..278d7a925ea00cb4bf975e42e58f88cc5475e9ed --- /dev/null +++ b/655/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues, then entry with 0° optics and inspection of the larynx. There is an exophytic mass in the area of the epiglottis, aryepiglottic fold, vocal folds on both sides, especially in the postcricoid region. The tumor extends ˝ cm into the subglottic slope. Then intubation by the anesthesiologist and repositioning for laryngoscopy. Entry with the small bore tube and inspection of the larynx. An exophytic mass is seen, starting from the left pocket fold with transition to the vocal folds, then transition to the arytenoid cartilage and infiltration of the postcricoid region and the arytenoid cartilage on the right side. The tumor also extends into the medial wall of the piriform sinus on the left side and into the aryepiglottic fold and the laryngeal surface of the epiglottis. The tip of the piriform sinus on the left side is free. The piriform sinus on the right side is completely free. The posterior pharyngeal wall is also free. Then insertion of a nasogastric tube and repositioning for esophagogastroscopy and insertion of a PEG using the thread pull-through method. With good diaphanoscopy, this can be done without any problems. Sterile washing and draping. Placement of an apron flap in the usual manner. Repositioning and beginning on the right side with exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digaster and the submandibular gland. Then exposure of the cervical vascular sheath. Detachment of the cervical vascular sheath from the larynx. Skeletonization of the larynx by exposing the hyoid bone and detaching the infrahyoid musculature. In the area of the larynx itself, muscles and soft tissue are left on the thyroid cartilage. Detachment of the thyroid gland and transection of the laryngeal artery, laryngeal vein and superior laryngeal nerve. Same procedure on the left side. Then perform the tracheotomy. To do this, cut through the thyroid isthmus and expose the anterior wall of the trachea. Insertion between the 3rd and 4th tracheal cartilage due to subglottic thinning. Then release of the hyoid bone and release of the piriform sinus on the right side of the thyroid cartilage. Then release of the piriform sinus, as far as possible, also on the left side. Then enter the pharynx above the hyoid bone. Pull out the epiglottis and inspect the tumor, which appears as described above. Cut along the epiglottis on the right side. Incision of the postcricoid region first on the right side, sparing the piriform sinus, then on the left side, where part of the piriform sinus must be removed in order to resect the tumor completely. Then detachment of the larynx from the esophageal entrance and removal of the larynx below the cricoid cartilage. The entire laryngeal preparation is thread-marked for frozen section. In the area of the piriform sinus entrance medial wall, a resection and a marginal specimen of the same name are taken. The marginal specimen and the laryngeal preparation are designated as R0 in the frozen section. In the meantime, perform the neck dissection, initially on the left side. The sternocleidomastoid muscle, the digaster muscle, the omohyoid muscle, the submandibular gland, the cervical vascular sheath and the accessorius nerve are exposed. Then release of the neck preparation II a to V a, sparing the plexus branches and repositioning for neck dissection on the right side by . Here also completion of the exposure of the neck borders of the sternocleidomastoid muscle, submandibular gland, omohyoid muscle, digaster muscle and accessor nerve, free preparation of the jugular vein and release of the neck preparation II a to V a, while sparing the plexus branches. Insertion of a Provox voice valve prosthesis in the usual manner. Provox size 6. Then the pharyngeal suture is performed in the usual manner, in two layers with single button sutures and the third layer adaptation of the pharyngeal muscles. The thyroid gland is very enlarged on both sides and is not sutured over the pharynx. The insertion of the sternocleidomastoid muscle is then reduced on both sides to achieve a flat stoma. Insertion of 2 Redon drainage tubes and suturing of the tracheostoma in the upper area. Two-layer wound closure and insertion of a 10 mm tracheostomy tube. The patient goes to the intensive care unit intubated and ventilated. Please continue antibiotics for 24 hours. X-ray gruel swallow on the 10th postoperative day, then, if there is no fistula, please resume diet. \ No newline at end of file diff --git a/656/InvasionFront_CD3_block22_x3_y3_patient656_0.json b/656/InvasionFront_CD3_block22_x3_y3_patient656_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8c5fb4c39df83863e279548dfdf17f018de0b811 --- /dev/null +++ b/656/InvasionFront_CD3_block22_x3_y3_patient656_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12393.4, + "Centroid Y µm": 18915.0, + "Num Detections": 17488, + "Num Negative": 12824, + "Num Positive": 4664, + "Positive %": 26.67, + "Num Positive per mm^2": 2314.5 + } +} \ No newline at end of file diff --git a/656/InvasionFront_CD3_block22_x4_y3_patient656_1.json b/656/InvasionFront_CD3_block22_x4_y3_patient656_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cfbe7abdbfee0d394b80295a9c16e75c1e15e9f0 --- /dev/null +++ b/656/InvasionFront_CD3_block22_x4_y3_patient656_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14717.2, + "Centroid Y µm": 19014.9, + "Num Detections": 18975, + "Num Negative": 15590, + "Num Positive": 3385, + "Positive %": 17.84, + "Num Positive per mm^2": 1657.4 + } +} \ No newline at end of file diff --git a/656/InvasionFront_CD8_block22_x3_y3_patient656_0.json b/656/InvasionFront_CD8_block22_x3_y3_patient656_0.json new file mode 100644 index 0000000000000000000000000000000000000000..59d77d86249235f4a9b23e1226d2a15619b10045 --- /dev/null +++ b/656/InvasionFront_CD8_block22_x3_y3_patient656_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14192.5, + "Centroid Y µm": 7695.9, + "Num Detections": 16192, + "Num Negative": 12186, + "Num Positive": 4006, + "Positive %": 24.74, + "Num Positive per mm^2": 2063.7 + } +} \ No newline at end of file diff --git a/656/InvasionFront_CD8_block22_x4_y3_patient656_1.json b/656/InvasionFront_CD8_block22_x4_y3_patient656_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c4ad91322a9bc3182d3a2a60bf857802c7fa10c8 --- /dev/null +++ b/656/InvasionFront_CD8_block22_x4_y3_patient656_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 7621.0, + "Num Detections": 17829, + "Num Negative": 14633, + "Num Positive": 3196, + "Positive %": 17.93, + "Num Positive per mm^2": 1611.4 + } +} \ No newline at end of file diff --git a/656/TumorCenter_CD3_block22_x3_y3_patient656_0.json b/656/TumorCenter_CD3_block22_x3_y3_patient656_0.json new file mode 100644 index 0000000000000000000000000000000000000000..892f195592095be3499ae542fe5bfe69756f66cf --- /dev/null +++ b/656/TumorCenter_CD3_block22_x3_y3_patient656_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11993.6, + "Centroid Y µm": 8370.6, + "Num Detections": 16270, + "Num Negative": 10511, + "Num Positive": 5759, + "Positive %": 35.4, + "Num Positive per mm^2": 2884.9 + } +} \ No newline at end of file diff --git a/656/TumorCenter_CD3_block22_x4_y3_patient656_1.json b/656/TumorCenter_CD3_block22_x4_y3_patient656_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e454b9c9767e982dfe3446e1e35a426fa99a2207 --- /dev/null +++ b/656/TumorCenter_CD3_block22_x4_y3_patient656_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14467.3, + "Centroid Y µm": 8445.5, + "Num Detections": 16770, + "Num Negative": 13318, + "Num Positive": 3452, + "Positive %": 20.58, + "Num Positive per mm^2": 1734.6 + } +} \ No newline at end of file diff --git a/656/TumorCenter_CD8_block22_x3_y3_patient656_0.json b/656/TumorCenter_CD8_block22_x3_y3_patient656_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ee16f78a934af22962c7ad995db363d78361013e --- /dev/null +++ b/656/TumorCenter_CD8_block22_x3_y3_patient656_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14292.4, + "Centroid Y µm": 17440.8, + "Num Detections": 15611, + "Num Negative": 7255, + "Num Positive": 8356, + "Positive %": 53.53, + "Num Positive per mm^2": 4184.0 + } +} \ No newline at end of file diff --git a/656/TumorCenter_CD8_block22_x4_y3_patient656_1.json b/656/TumorCenter_CD8_block22_x4_y3_patient656_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0f76ac5a30cf83d8f9922cdb9be9d33070f1b8ea --- /dev/null +++ b/656/TumorCenter_CD8_block22_x4_y3_patient656_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16741.1, + "Centroid Y µm": 17490.7, + "Num Detections": 16231, + "Num Negative": 10981, + "Num Positive": 5250, + "Positive %": 32.35, + "Num Positive per mm^2": 2655.2 + } +} \ No newline at end of file diff --git a/656/history_text.txt b/656/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/656/icd_codes.txt b/656/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..739d9698e26651477346fcfa3195fb70564f6265 --- /dev/null +++ b/656/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] \ No newline at end of file diff --git a/656/ops_codes.txt b/656/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..117334c91818fb48490e6dc85498766f9bffb6af --- /dev/null +++ b/656/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] \ No newline at end of file diff --git a/656/patient_clinical_data.json b/656/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..34316cec936b6f39cdc868a29f26aa6b9d98cc95 --- /dev/null +++ b/656/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/656/patient_pathological_data.json b/656/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..40b9987fb790542b3131ba688c45d16c6365d0a1 --- /dev/null +++ b/656/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "656", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/656/surgery_description.txt b/656/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..06c55fdcc0738bdb57094cf95b5b019597a4a572 --- /dev/null +++ b/656/surgery_description.txt @@ -0,0 +1 @@ +LE with partial pharyngectomy, Bilateral neck dissection, PEG diff --git a/656/surgery_report.txt b/656/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7802f889d0f40eed3c9b09732a72ddb507dcac0c --- /dev/null +++ b/656/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Introductory consultation with the anesthesia colleagues. Induction of intubation anesthesia by the colleagues. Start of surgery using oesophagogastroscopy with the flexible instrument. After performing a positive diaphanoscopy, the PEG tube is placed in the usual way using the thread pull-through method. No complications here. Panendoscopy to determine the extent of the tumor. The tumor is mainly located in the left piriform sinus and spreads to parts of the lateral pharyngeal wall. The posterior pharyngeal wall and postcricoid region are free. The patient is now repositioned in the head reclination position and the surgical field is covered and wiped. Start the operation by means of an apron flap incision extending caudally to just below the cricoid. Care is taken to make the incision approx. 2 QF below the mandible so as not to jeopardize the marginal ramus. After cutting through the cutis and subcutis as well as the platysma, the subplatysmal preparation of the apron flap is carried out in the usual way from caudal to cranial. After exposing the submandibular gland on both sides, the apron flap is sutured. Now expose the anterior edge of the muscle on the left side and perform the left neck dissection by . To do this, expose the sternocleidomastoid muscle in depth. Exposure of the omohyoid muscle and dissection up to the cranial hyoid bone. Knockdown of the omohyoid muscle. Identification and free dissection of the accessorius nerve. Identification of the digastric muscle. Now also identification of the cervical vascular sheath and freeing of the cervical vascular sheath from the neck preparation. Regions II, III, IV and V are removed en bloc from cranial to caudal while sparing the nervous and vascular structures. Subtle hemostasis using bipolar coagulation forceps. During dissection, the hypoglossal nerve is exposed and followed medially. The superior thyroid artery and the superior laryngeal nerve are also exposed. Laryngeal exposure after placement of vascular clips and bipolar coagulation. Now also preoperative release of the cervical vascular nerve sheath from the pharyngeal musculature. Perform isthmus splitting on the thyroid gland and separation of the thyroid gland from the laryngeal skeleton on both sides. Now enter the 3rd intertracheal space and transfer intubation to an 8 mm LE tube. Neck dissection on the right side by . Same procedure as on the left side. The superior thyroid artery is dissected free and also clipped at its division in order to obtain a possible connecting vessel with a free flap. Dissection of the thyroid gland and free dissection of the common carotid artery. Release of the major and minor cornu of the hyoid bone. Now release the right piriform sinus, for this purpose the upper edge of the cartilage with the upper horn is incised and slit with a new 15 mm knife and the piriform sinus is bluntly released using a freer. On the left side, only the upper horn is released to avoid entering the tumor, which is mainly located in the piriform sinus. Now perform the tracheotomy in the 3rd interspace and suture the lower sutures in a characteristic manner. Now enter suprahyoidally and locate the epiglottis. Pull up the epiglottis and dissect the pharyngeal mucosa in order to protect it as much as possible. The pharyngeal mucosa is now incised on the right side close to the epiglottis and dissected up to the aryepiglottic fold or arytenoid cartilage. Great care is taken here to ensure that as much mucosa as possible is spared. The subcutaneous fatty tissue is also removed while preserving the piriform sinus. Now dissection along the epiglottis on the left side. The tumor is clearly visible as an ulcer in the lateral pharyngeal wall as well as the medial wall of the piriform sinus and the aryepiglottic fold; there is also a small exophytic extension to the lateral posterior, where the tumor is bypassed at a distance of 1 cm. The remaining mucosa is spared. Connect the two mucosal incisions at the level of the cricoid. Now enter the trachea or detach the trachea directly below the cricoid. Creation of a chimney and placement of the trachea under the cricoid after preparation of a caudally pedicled mucosal flap from the cricoid cartilage plate for the chimney using a scalpel and Freer. A total of 3 cartilage clips are obtained above the tracheostoma, the lowest cartilage clip of which is incised and divided in the middle to ensure a particularly wide tracheostoma. Now release the cricoid from below close to the larynx and connect the two preparation parts. Removal of the larynx on closer inspection of the larynx, the tumor looks widely resected in situ with a safety margin of 1 cm in each direction. Now 7 marginal samples are taken, these are free of tumor in the frozen section afterwards (R0). Perform a myotomy of the inferior hypopharyngeal muscle and insert an 8-gauge Provox. Now close the wound using inverted sutures in the usual technique and in a T-shape. As a second layer, the muscles of the constrictor pharyngis muscle are sutured over the first suture. The esophagus should be sufficiently wide. Careful and gradual hemostasis on both sides and irrigation of the site. Insertion of two 10-gauge Redon drains, two-layer wound closure and suturing of the tracheostoma in the usual manner. Re-intubation with a 10-gauge Rüsch cannula and completion of the operation after a final consultation with the anesthetist. \ No newline at end of file diff --git a/657/InvasionFront_CD3_block9_x5_y10_patient657_0.json b/657/InvasionFront_CD3_block9_x5_y10_patient657_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ef6006ac46ab69684377ea36aeb9d76f13dabb49 --- /dev/null +++ b/657/InvasionFront_CD3_block9_x5_y10_patient657_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16916.0, + "Centroid Y µm": 26735.8, + "Num Detections": 7801, + "Num Negative": 7562, + "Num Positive": 239, + "Positive %": 3.064, + "Num Positive per mm^2": 186.64 + } +} \ No newline at end of file diff --git a/657/InvasionFront_CD3_block9_x6_y10_patient657_1.json b/657/InvasionFront_CD3_block9_x6_y10_patient657_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e4a230c229e58a07d6116d869e937252fbb2ef3a --- /dev/null +++ b/657/InvasionFront_CD3_block9_x6_y10_patient657_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19414.7, + "Centroid Y µm": 26486.0, + "Num Detections": 17940, + "Num Negative": 17621, + "Num Positive": 319, + "Positive %": 1.778, + "Num Positive per mm^2": 136.89 + } +} \ No newline at end of file diff --git a/657/InvasionFront_CD8_block9_x5_y10_patient657_0.json b/657/InvasionFront_CD8_block9_x5_y10_patient657_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fc95944842132fa95b75579e430f037abde5a5ec --- /dev/null +++ b/657/InvasionFront_CD8_block9_x5_y10_patient657_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 30284.0, + "Num Detections": 16955, + "Num Negative": 15766, + "Num Positive": 1189, + "Positive %": 7.013, + "Num Positive per mm^2": 557.49 + } +} \ No newline at end of file diff --git a/657/InvasionFront_CD8_block9_x6_y10_patient657_1.json b/657/InvasionFront_CD8_block9_x6_y10_patient657_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6e56c24243f4737a2c816fb652cbe9ce3ebbfd4 --- /dev/null +++ b/657/InvasionFront_CD8_block9_x6_y10_patient657_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19564.6, + "Centroid Y µm": 29859.2, + "Num Detections": 17754, + "Num Negative": 17366, + "Num Positive": 388, + "Positive %": 2.185, + "Num Positive per mm^2": 167.9 + } +} \ No newline at end of file diff --git a/657/TumorCenter_CD3_block9_x5_y10_patient657_0.json b/657/TumorCenter_CD3_block9_x5_y10_patient657_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ddb5137c8bc362bc6d884978f0a1105f1f167911 --- /dev/null +++ b/657/TumorCenter_CD3_block9_x5_y10_patient657_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 30783.7, + "Num Detections": 18335, + "Num Negative": 17422, + "Num Positive": 913, + "Positive %": 4.98, + "Num Positive per mm^2": 397.93 + } +} \ No newline at end of file diff --git a/657/TumorCenter_CD3_block9_x6_y10_patient657_1.json b/657/TumorCenter_CD3_block9_x6_y10_patient657_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c46fb84a506f608d63d8e701127c23f4b22c0ec --- /dev/null +++ b/657/TumorCenter_CD3_block9_x6_y10_patient657_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18490.2, + "Centroid Y µm": 30808.7, + "Num Detections": 16888, + "Num Negative": 14397, + "Num Positive": 2491, + "Positive %": 14.75, + "Num Positive per mm^2": 1044.8 + } +} \ No newline at end of file diff --git a/657/TumorCenter_CD8_block9_x5_y10_patient657_0.json b/657/TumorCenter_CD8_block9_x5_y10_patient657_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8bb3ba4ddb0fe304ffdb48c7f2e1131a818dd530 --- /dev/null +++ b/657/TumorCenter_CD8_block9_x5_y10_patient657_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16766.1, + "Centroid Y µm": 26136.2, + "Num Detections": 15770, + "Num Negative": 15359, + "Num Positive": 411, + "Positive %": 2.606, + "Num Positive per mm^2": 205.75 + } +} \ No newline at end of file diff --git a/657/TumorCenter_CD8_block9_x6_y10_patient657_1.json b/657/TumorCenter_CD8_block9_x6_y10_patient657_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4e9e4f3ea942b968a3bc3891335f98a9511027f5 --- /dev/null +++ b/657/TumorCenter_CD8_block9_x6_y10_patient657_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19239.8, + "Centroid Y µm": 26111.2, + "Num Detections": 15490, + "Num Negative": 12443, + "Num Positive": 3047, + "Positive %": 19.67, + "Num Positive per mm^2": 1503.2 + } +} \ No newline at end of file diff --git a/657/history_text.txt b/657/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fd67f144463e50ce78712774511eb72d69b8191a --- /dev/null +++ b/657/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT2 to 3 oropharyngeal carcinoma on the right. The above-mentioned operation was therefore indicated. The patient was also informed about the possible need for flap surgery. \ No newline at end of file diff --git a/657/icd_codes.txt b/657/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a52e4a153cae32e09a70b23818175abb91f78e61 --- /dev/null +++ b/657/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des weichen Gaumens (vordere Gaumenbogen rechts, Ausbreitung Zungenrand rechts)[C05.1 R] Zervikale Lymphknotenmetastase[C77.0 R] \ No newline at end of file diff --git a/657/ops_codes.txt b/657/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..050861000d2fd62affe1356e7412affa474fab53 --- /dev/null +++ b/657/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Transorale radikale Resektion des Pharynx ohne Rekonstruktion[5-296.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 L] Temporäre Tracheotomie[5-311.0 ] \ No newline at end of file diff --git a/657/patient_clinical_data.json b/657/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ab7101d9f6cd515a1d4275ea5853e70144ac6699 --- /dev/null +++ b/657/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/657/patient_pathological_data.json b/657/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..58cd58696a95f2c239aa4c5a9956ff1d0276cfb6 --- /dev/null +++ b/657/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "657", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/657/surgery_description.txt b/657/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..aa33a429b8f584450472bc9ef62c720083488175 --- /dev/null +++ b/657/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheostomy creation diff --git a/657/surgery_report.txt b/657/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1fbb5a9ccd110e5745e8278f8d968ee30fe6b361 --- /dev/null +++ b/657/surgery_report.txt @@ -0,0 +1 @@ +() Pharyngoscopy and laryngoscopy: The exophytic tumor is visible, which leads from the anterior palatal arch via the tonsillar lobe, the alveolar ridge and the floor of the mouth to the edge and base of the tongue. Attempt at PEG insertion: Insertion with the esophagoscope. Advance into the stomach. However, diaphanoscopy cannot be established here and PEG placement cannot be carried out with sufficient certainty. The attempt to insert a PEG is therefore discontinued. If necessary, this would then have to be performed secondarily in surgery or internal medicine. Alternate positioning of the head and insertion of the McIvor blade or retractor. Exposure of the tumor. This runs from the anterior palatal arch over the alveolar ridge onto the floor of the mouth to the base of the tongue, which infiltrates minimally, with anterior infiltration of the edge of the tongue on the right. A tumor cone can also be felt in the edge of the tongue, individual satellites at the transition to the floor of the mouth. The tumor is now resected with a safety margin of at least 1 ˝ cm on all sides. The anterior palatal arch and the soft tissues above the alveolar ridge are removed, although the periosteal layer can be preserved here. The resection also includes the tonsil lobe with adjacent musculature, transition to the floor of the mouth, where the lingual nerve is exposed but can be preserved, as can the Wharton's duct. The resection leads over the floor of the mouth into the edge of the tongue, which is resected over a width of 1 to 2 cm in the posterior region, as is a small part of the base of the tongue. The preparation is thread-marked. Another separate marginal sample from the basal area of the tongue margin is also taken, here including a large slice of muscle. Both the entire specimen and the marginal specimen in healthy tissue, thus R0 resection in a frozen section. Indication for flap creation borderline. Due to the preserved posterior palatal arch, the coverage of the bone in the ascending mandibular branch and the still well-preserved mucosal area in the area of the glossoalveolar groove, the decision was made not to perform a flap here. Therefore, repositioning for neck dissection on both sides. (V. Bezas) Neck dissection on both sides and temporary tracheostomy. Initial repositioning for neck dissection on the right. Curved skin incision in typical manner. After cutting through the skin and subcutaneous tissue and the platysma, expose the anterior border of the sternocleidomastoid muscle. Partly sharp, partly blunt dissection and exposure of the important anatomical structures (omohyoid muscle, digastric muscle, infrahyoid muscles). Exposure of the cervical vascular sheath. Dissection of the internal jugular vein. Exposure of the internal jugular vein. Exposure of the common carotid artery, external carotid artery and internal carotid artery. Including exposure of the vagus nerve. Further dissection to the cranial side, here the hypoglossal nerve and the hypoglossal sac are exposed under the digastric muscle. Exposure of the nervus accessorius and free preparation of the neck dissectate from cranial to caudal. Further successive dissection and entrainment of the nodes from level II to V. The branches of the cervical plexus are preserved. Subtle hemostasis. Creation of a Redon drainage. Two-layer suture. Now proceed to neck dissection on the left side. Here the dissection is carried out in the usual way as on the right side. Here, however, with cN0 sonographic findings, the neck dissection is performed at levels II to IV. After careful hemostasis, irrigation with hydrogen and Ringer's solution. Application of a Redon drainage. Two-layer suture. Now proceed to permanent tracheostomy. Small Kocher's collar incision approximately 2 transverse fingers above the jugulum on the palpatory cricoid cartilage. Cut through the skin and subcutis. Expose the prelaryngeal musculature of the linea alba. Successive dissection in the midline and removal of the prelaryngeal neck musculature. Exposure of the thyroid gland. Palpation of the borders of the tracheal skeleton. Local coagulation and visualization of the upper limits of the thyroid isthmus. After clamping, local hemostasis and transection. Puncture ligatures and removal of the clamps. Visualization of the anterior wall of the trachea. Palpation and incision between the 2nd and 3rd tracheal cartilage in the sense of a visor tracheotomy. Subsequent suturing of the skin to the tracheal cartilage. Re-intubation and insertion of a tracheal cannula. This is fixed with suture. Transition to the oral cavity. After removing the compresses, the wound is inspected again. The bleeding is carefully stopped. At the same time, a nasogastric tube is inserted without any problems. Removal of all instruments and swabs. Completion of the operation. () Total cT2 to 3 oropharyngeal carcinoma R0 resected. Neck dissection with at least cN1 to cN2b status. Therefore evacuation of level II to V. Nutrition via the inserted gastric tube for approx. 1 week. Then, depending on the swallowing situation, a decision is made to insert a PEG, which should then be inserted in surgery or internal medicine. Waiting for the final histology and discussion of the patient in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/658/InvasionFront_CD3_block14_x3_y8_patient658_0.json b/658/InvasionFront_CD3_block14_x3_y8_patient658_0.json new file mode 100644 index 0000000000000000000000000000000000000000..182e7f20ba3a3333ea68aa3544f412145fac2dea --- /dev/null +++ b/658/InvasionFront_CD3_block14_x3_y8_patient658_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11643.8, + "Centroid Y µm": 23937.3, + "Num Detections": 12310, + "Num Negative": 11379, + "Num Positive": 931, + "Positive %": 7.563, + "Num Positive per mm^2": 661.16 + } +} \ No newline at end of file diff --git a/658/InvasionFront_CD3_block14_x4_y8_patient658_1.json b/658/InvasionFront_CD3_block14_x4_y8_patient658_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2522fdef04fcb4fd203da43dbf07ed62c99daded --- /dev/null +++ b/658/InvasionFront_CD3_block14_x4_y8_patient658_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14267.4, + "Centroid Y µm": 23912.3, + "Num Detections": 17626, + "Num Negative": 17567, + "Num Positive": 59, + "Positive %": 0.3347, + "Num Positive per mm^2": 26.83 + } +} \ No newline at end of file diff --git a/658/InvasionFront_CD8_block14_x3_y8_patient658_0.json b/658/InvasionFront_CD8_block14_x3_y8_patient658_0.json new file mode 100644 index 0000000000000000000000000000000000000000..731576ebb56078c7ca929b62f5d9ab1e7dc3af74 --- /dev/null +++ b/658/InvasionFront_CD8_block14_x3_y8_patient658_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 19664.6, + "Num Detections": 13430, + "Num Negative": 12644, + "Num Positive": 786, + "Positive %": 5.853, + "Num Positive per mm^2": 533.78 + } +} \ No newline at end of file diff --git a/658/InvasionFront_CD8_block14_x4_y8_patient658_1.json b/658/InvasionFront_CD8_block14_x4_y8_patient658_1.json new file mode 100644 index 0000000000000000000000000000000000000000..82272b5adcc0e686adc2e6227f476a985b37b6d9 --- /dev/null +++ b/658/InvasionFront_CD8_block14_x4_y8_patient658_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 19564.6, + "Num Detections": 19333, + "Num Negative": 19279, + "Num Positive": 54, + "Positive %": 0.2793, + "Num Positive per mm^2": 24.1 + } +} \ No newline at end of file diff --git a/658/TumorCenter_CD3_block14_x3_y8_patient658_0.json b/658/TumorCenter_CD3_block14_x3_y8_patient658_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a7455b76ff8fda4cc94e623ce52180ff27bf60df --- /dev/null +++ b/658/TumorCenter_CD3_block14_x3_y8_patient658_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 20314.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/658/TumorCenter_CD3_block14_x4_y8_patient658_1.json b/658/TumorCenter_CD3_block14_x4_y8_patient658_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6b5525080d9a840dce55ef66bfe5173cb91acd11 --- /dev/null +++ b/658/TumorCenter_CD3_block14_x4_y8_patient658_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 20489.2, + "Num Detections": 23103, + "Num Negative": 19766, + "Num Positive": 3337, + "Positive %": 14.44, + "Num Positive per mm^2": 1345.4 + } +} \ No newline at end of file diff --git a/658/TumorCenter_CD8_block14_x3_y8_patient658_0.json b/658/TumorCenter_CD8_block14_x3_y8_patient658_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebb7f7b96f03d254da6752186b719296c6f4b294 --- /dev/null +++ b/658/TumorCenter_CD8_block14_x3_y8_patient658_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10644.4, + "Centroid Y µm": 20464.2, + "Num Detections": 7279, + "Num Negative": 7041, + "Num Positive": 238, + "Positive %": 3.27, + "Num Positive per mm^2": 225.36 + } +} \ No newline at end of file diff --git a/658/TumorCenter_CD8_block14_x4_y8_patient658_1.json b/658/TumorCenter_CD8_block14_x4_y8_patient658_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54ac784e497e7d2935eb8a0f7dfd315e6fb82ea1 --- /dev/null +++ b/658/TumorCenter_CD8_block14_x4_y8_patient658_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13218.0, + "Centroid Y µm": 20539.1, + "Num Detections": 23199, + "Num Negative": 20199, + "Num Positive": 3000, + "Positive %": 12.93, + "Num Positive per mm^2": 1219.5 + } +} \ No newline at end of file diff --git a/658/history_text.txt b/658/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6be2dcfefd9755658c245558bbcd9eaaeb6970f --- /dev/null +++ b/658/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: The patient has a histologically confirmed malignant tumor of the left edge of the tongue, clinically T2. Due to this, indication for tumor resection with neck dissection on the left. \ No newline at end of file diff --git a/658/icd_codes.txt b/658/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/658/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/658/ops_codes.txt b/658/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..06be4313d9119c21272c43ca81d28b4cba24aaa0 --- /dev/null +++ b/658/ops_codes.txt @@ -0,0 +1 @@ +Partielle Glossektomie transoral sonstige[5-251.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] \ No newline at end of file diff --git a/658/patient_clinical_data.json b/658/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6437051d96493c178514e69dd995f9fa571fbc39 --- /dev/null +++ b/658/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 19, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/658/patient_pathological_data.json b/658/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4511e48628c3aab1a419e477228ed9e3b1e47ffe --- /dev/null +++ b/658/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "658", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/658/surgery_description.txt b/658/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..35b8644c659bdea0d6b2b762a75676b5d55f7939 --- /dev/null +++ b/658/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Neck dissection on the left diff --git a/658/surgery_report.txt b/658/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d9ede6528094e34d2062c75f2bdec97e30eda063 --- /dev/null +++ b/658/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthetist. Then advance the 0° optic through the glottic plane into the trachea. Inconspicuous mucosal conditions in the area of the trachea up to the exit of the segmental bronchi. Now ......... Patients. Advance the flexible esophagoscope into the stomach. Inconspicuous mucosal conditions in the area of the stomach. Mirroring back. No abnormalities in the area of the esophagus. Now inspect the hypopharynx on both sides and the postcricoid region. Inconspicuous mucosal conditions on all sides. Inspection of the larynx after insertion of the small drainage tube. In the subglottis, glottis and supraglottis areas, the mucous membrane conditions are unremarkable. Inspection of the oropharynx and nasopharynx after pulling up the soft palate. All inspections with the aid of the endoscope or microscope. Now position the patient. Insert the mouth retractor and pull out the tongue. The described tongue margin carcinoma on the left with an extension of approx. 2.5 cm, thus clinically T2. Careful resection of this tumor in all planes in the healthy area. Bleeding is stopped with bipolar coagulation or by ligation. The specimen is completely removed and marked. The specimen is marked and sent for pathological frozen section examination. A resection in sano is confirmed at all levels. Finally, adequate hemostasis. Dry conditions at the end of the operation. Now reposition the patient. Local anesthesia is administered in the area of the left neck, abjodation, covering of the surgical area. Skin incision from the tip of the mastoid to the clavicle. Dissection of the subcutaneous tissue, dissection of the platysma, exposure of the external jugular vein, exposure of the auricular nerve. Both the external jugular vein and the auricular nerve are displaced cranially and re-embedded in their original bed at the end of the operation. Exposure of the sternocleidomastoid muscle, exposure of the accessorius nerve, exposure of the common carotid artery, internal and external carotid artery, internal jugular vein, hyperglossal nerve and vagus nerve. There are larger lymph nodes in the area of level II as well as in the area of level IV and V, whereby the macroscopic aspect appears rather inconspicuous. Now expose the posterior venter, the digastric mucus and clear out levels IV and V while sparing the accessorius nerve and the cervical and brachial plexus. Deposit the preparation at the level of the omohyoid muscle. Now remove the ........... connective tissue in the area of levels II and III. The capsule of the submandibular gland is exposed and also resected. This results in a modified level II-V radical neck dissection. Irrigation of the wound with water and hydrogen. Insertion of a Redon drainage, wound closure in layers. Final discussion with the anesthetist. Further procedure depending on the histology. \ No newline at end of file diff --git a/659/InvasionFront_CD3_block22_x1_y9_patient659_0.json b/659/InvasionFront_CD3_block22_x1_y9_patient659_0.json new file mode 100644 index 0000000000000000000000000000000000000000..569e8387564d23b49c73c8ee1e61d36066091f24 --- /dev/null +++ b/659/InvasionFront_CD3_block22_x1_y9_patient659_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 34156.9, + "Num Detections": 20884, + "Num Negative": 19689, + "Num Positive": 1195, + "Positive %": 5.722, + "Num Positive per mm^2": 511.77 + } +} \ No newline at end of file diff --git a/659/InvasionFront_CD3_block22_x2_y9_patient659_1.json b/659/InvasionFront_CD3_block22_x2_y9_patient659_1.json new file mode 100644 index 0000000000000000000000000000000000000000..73cf32b44677b0e65e1cdf343b1e5bdb3a236ac8 --- /dev/null +++ b/659/InvasionFront_CD3_block22_x2_y9_patient659_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 34381.8, + "Num Detections": 20891, + "Num Negative": 19836, + "Num Positive": 1055, + "Positive %": 5.05, + "Num Positive per mm^2": 466.35 + } +} \ No newline at end of file diff --git a/659/InvasionFront_CD8_block22_x1_y9_patient659_0.json b/659/InvasionFront_CD8_block22_x1_y9_patient659_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a120f75ac391b9717e6bfc5c98ac3c957dcf5b48 --- /dev/null +++ b/659/InvasionFront_CD8_block22_x1_y9_patient659_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6924.9, + "Centroid Y µm": 22695.4, + "Num Detections": 20130, + "Num Negative": 19591, + "Num Positive": 539, + "Positive %": 2.678, + "Num Positive per mm^2": 241.25 + } +} \ No newline at end of file diff --git a/659/InvasionFront_CD8_block22_x2_y9_patient659_1.json b/659/InvasionFront_CD8_block22_x2_y9_patient659_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9217d620d7c4af16c0f51819fd3f1a634c6b2061 --- /dev/null +++ b/659/InvasionFront_CD8_block22_x2_y9_patient659_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9227.3, + "Centroid Y µm": 22858.5, + "Num Detections": 19744, + "Num Negative": 18925, + "Num Positive": 819, + "Positive %": 4.148, + "Num Positive per mm^2": 380.99 + } +} \ No newline at end of file diff --git a/659/TumorCenter_CD3_block22_x1_y9_patient659_0.json b/659/TumorCenter_CD3_block22_x1_y9_patient659_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7ac8e4c31a034522895854792d5167fa2b160582 --- /dev/null +++ b/659/TumorCenter_CD3_block22_x1_y9_patient659_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3686.4, + "Centroid Y µm": 22519.8, + "Num Detections": 9014, + "Num Negative": 8844, + "Num Positive": 170, + "Positive %": 1.886, + "Num Positive per mm^2": 126.62 + } +} \ No newline at end of file diff --git a/659/TumorCenter_CD3_block22_x2_y9_patient659_1.json b/659/TumorCenter_CD3_block22_x2_y9_patient659_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8a60c19225fdfc628ce709b7f77ea9f96ffbfa59 --- /dev/null +++ b/659/TumorCenter_CD3_block22_x2_y9_patient659_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6493.2, + "Centroid Y µm": 22817.9, + "Num Detections": 7172, + "Num Negative": 6865, + "Num Positive": 307, + "Positive %": 4.281, + "Num Positive per mm^2": 242.28 + } +} \ No newline at end of file diff --git a/659/TumorCenter_CD8_block22_x1_y9_patient659_0.json b/659/TumorCenter_CD8_block22_x1_y9_patient659_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bdc7b147cbffdd9d288c2e0b5f352df064529b55 --- /dev/null +++ b/659/TumorCenter_CD8_block22_x1_y9_patient659_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5598.1, + "Centroid Y µm": 32277.7, + "Num Detections": 8763, + "Num Negative": 8556, + "Num Positive": 207, + "Positive %": 2.362, + "Num Positive per mm^2": 181.73 + } +} \ No newline at end of file diff --git a/659/TumorCenter_CD8_block22_x2_y9_patient659_1.json b/659/TumorCenter_CD8_block22_x2_y9_patient659_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dec36e433e7592a3d9a66d9e41ba8007e44c8ec3 --- /dev/null +++ b/659/TumorCenter_CD8_block22_x2_y9_patient659_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8428.8, + "Centroid Y µm": 32575.9, + "Num Detections": 10667, + "Num Negative": 10560, + "Num Positive": 107, + "Positive %": 1.003, + "Num Positive per mm^2": 77.96 + } +} \ No newline at end of file diff --git a/659/history_text.txt b/659/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..54540fe4ed43f538b58fa2eb52b0a1c1b28dbe85 --- /dev/null +++ b/659/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed endolaryngeal squamous cell carcinoma. The carcinoma is located in the arytenoid/interary region and dorsally on the cricoid cartilage. Mainly infiltration of the cricoid cartilage and at least growth to the thyroid cartilage. Due to the overall situation, surgical therapy in the sense of a laryngectomy vs. RCT. Decision to operate due to suspected cartilage infiltration. \ No newline at end of file diff --git a/659/icd_codes.txt b/659/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3e2a012bd85a7268675389b6e7372701d7a2e1bc --- /dev/null +++ b/659/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 ] Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/659/ops_codes.txt b/659/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e4188a70903ee31fbec4481d9ea021babd660361 --- /dev/null +++ b/659/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie ohne Rekonstruktion[5-303.00 ] Selektive Neck dissection in 6 Regionen[5-403.05 B] \ No newline at end of file diff --git a/659/patient_clinical_data.json b/659/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a0bea3231ed546eb2f1773c58df0e06be5558f8e --- /dev/null +++ b/659/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/659/patient_pathological_data.json b/659/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e54af9f2cef2b1013854ebe46b1d21b4e6f98388 --- /dev/null +++ b/659/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "659", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/659/surgery_description.txt b/659/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fec7e6072953c12fd07c3efae885d66e5891821 --- /dev/null +++ b/659/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Provox insertion diff --git a/659/surgery_report.txt b/659/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..837e5c8570dacb4cfb5b0a18fe7f1d38cc7b4a40 --- /dev/null +++ b/659/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: The exophytic tumor can be seen, which is centrally located, extends to the subglottic area, grows into the arytenoid region and into the arytenoid fold at the back of the cricoid cartilage. Thus confirmation of the tumor location. Overall cT3 tumor, which cannot be sensibly operated on with laryngeal preservation. Therefore, transfer for laryngectomy and neck dissection. First, skin disinfection and injection of a total of 20 ml Ultracaine 1% with adrenaline into both sides of the neck and sterile draping of all relevant surgical areas. The patient is already tracheotomized and the tube is removed caudally. First, an apron flap is created in the typical manner up to the level of the hyoid bone and submandibular gland. Then neck dissection on the right: exposure of the sternocleidomastoid muscle. Exposure of the omohyoid and digastric muscles. Exposure of the internal carotid artery, external carotid artery and superior thyroid artery. Visualization of the internal jugular vein. Depiction of the hypoglossal nerve. Hypoglossal nerve, vagus nerve, accessorius nerve. Successive evacuation Level II to IV. Evacuation includes small parts of Level V. Neck dissection is performed while preserving and exposing the branches of the cervical plexus. Subsequent neck dissection on the left: This is performed in the same way as on the right side. Evacuation of level II to IV as well as small parts of V. Visualization and preservation of the same structures. Overall, no significant lymph nodes. Then mobilization of the larynx and laryngectomy: visualization of the hyoid bone. Dissection of suprahyoid muscles. Subsequent dissection of the sternohyoid muscle. Exposure of the superior cornu and dissection of the pharyngeal tube. Caudal dissection of the thyroid gland, which is dissected caudolaterally. Remains of the isthmus are coagulated bipolarly. Mobilization of the larynx on both sides in the same way. Subsequent exposure of the epiglottis. The pre-epiglottic soft tissues are included in the preparation together with the hyoid bone. Entering the larynx. Exposure of the epiglottis. Cut along the epiglottis and the aryepiglottic fold on both sides. Successive development of the larynx. Bipolar coagulation of the vessels between the larynx and pharyngeal tube. Dissect down to the esophageal opening. Subsequent removal of the larynx. Suture marking of the larynx. No cranial, caudal or basal tumor margins in the frozen section. Therefore R0 resection. Myotomy now performed on the left by cutting the muscles down to the level of the mucosa. This resulted in a noticeable widening of the pharyngeal inlet. Subsequent insertion of a 10 mm Provox prosthesis in the typical manner without complications. Then suturing of the pharynx in an inverted 1st suture with Vicryl 4-0 single button sutures. Then the 2nd suture inverted over it, also with 4-0 Vicryl single button sutures. Then suture the constrictor muscle and the suprahyoid muscles using 3-0 Vicryl single button sutures. Subsequent suturing of the sternohyoid muscle in the middle. As already done several times, especially after tumor resection, extensive irrigation with hemostasis. Then epithelialization of the trachea on the loosened apron flaps. This is done without tension. Then wound closure in layers with insertion of a Redon drain on both sides. Completion of the procedure without complications. Patient received Unacid intraoperatively, please continue antibiotics for 1 week. Feeding via the inserted PEG tube for 10 days, then X-ray gruel and, if necessary, diet build-up. Overall cT3 cN0 laryngeal carcinoma. Awaiting final histology. Discussion of further procedure in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/660/InvasionFront_CD3_block14_x1_y10_patient660_0.json b/660/InvasionFront_CD3_block14_x1_y10_patient660_0.json new file mode 100644 index 0000000000000000000000000000000000000000..773ac261a8a53ba4dfd242e4f878155c0d7cb261 --- /dev/null +++ b/660/InvasionFront_CD3_block14_x1_y10_patient660_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4110.3, + "Centroid Y µm": 28622.3, + "Num Detections": 11101, + "Num Negative": 10595, + "Num Positive": 506, + "Positive %": 4.558, + "Num Positive per mm^2": 371.15 + } +} \ No newline at end of file diff --git a/660/InvasionFront_CD3_block14_x2_y10_patient660_1.json b/660/InvasionFront_CD3_block14_x2_y10_patient660_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cd7450bae644ebe942f59fc739059258f968b260 --- /dev/null +++ b/660/InvasionFront_CD3_block14_x2_y10_patient660_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6708.9, + "Centroid Y µm": 28697.3, + "Num Detections": 10706, + "Num Negative": 10484, + "Num Positive": 222, + "Positive %": 2.074, + "Num Positive per mm^2": 127.77 + } +} \ No newline at end of file diff --git a/660/InvasionFront_CD8_block14_x1_y10_patient660_0.json b/660/InvasionFront_CD8_block14_x1_y10_patient660_0.json new file mode 100644 index 0000000000000000000000000000000000000000..418758818153ebda155bfcecd59b4ca468107615 --- /dev/null +++ b/660/InvasionFront_CD8_block14_x1_y10_patient660_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4497.6, + "Centroid Y µm": 24337.1, + "Num Detections": 16577, + "Num Negative": 15832, + "Num Positive": 745, + "Positive %": 4.494, + "Num Positive per mm^2": 350.35 + } +} \ No newline at end of file diff --git a/660/InvasionFront_CD8_block14_x2_y10_patient660_1.json b/660/InvasionFront_CD8_block14_x2_y10_patient660_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c9cde9184d9db1955100a2488699ee862647abe --- /dev/null +++ b/660/InvasionFront_CD8_block14_x2_y10_patient660_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7096.2, + "Centroid Y µm": 24362.1, + "Num Detections": 11805, + "Num Negative": 11546, + "Num Positive": 259, + "Positive %": 2.194, + "Num Positive per mm^2": 129.74 + } +} \ No newline at end of file diff --git a/660/TumorCenter_CD3_block14_x1_y10_patient660_0.json b/660/TumorCenter_CD3_block14_x1_y10_patient660_0.json new file mode 100644 index 0000000000000000000000000000000000000000..01c253e9d2b61727a83a0c2bb2a3c2b155230ec1 --- /dev/null +++ b/660/TumorCenter_CD3_block14_x1_y10_patient660_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3673.1, + "Centroid Y µm": 24886.8, + "Num Detections": 15173, + "Num Negative": 14847, + "Num Positive": 326, + "Positive %": 2.149, + "Num Positive per mm^2": 150.81 + } +} \ No newline at end of file diff --git a/660/TumorCenter_CD3_block14_x2_y10_patient660_1.json b/660/TumorCenter_CD3_block14_x2_y10_patient660_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7f6db6f5115803203155da637597dfb284382992 --- /dev/null +++ b/660/TumorCenter_CD3_block14_x2_y10_patient660_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 25136.7, + "Num Detections": 12619, + "Num Negative": 12253, + "Num Positive": 366, + "Positive %": 2.9, + "Num Positive per mm^2": 196.96 + } +} \ No newline at end of file diff --git a/660/TumorCenter_CD8_block14_x1_y10_patient660_0.json b/660/TumorCenter_CD8_block14_x1_y10_patient660_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2f0c21c3e41b75c9a378fd59a8023975f6011e84 --- /dev/null +++ b/660/TumorCenter_CD8_block14_x1_y10_patient660_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3348.2, + "Centroid Y µm": 25336.6, + "Num Detections": 13220, + "Num Negative": 12987, + "Num Positive": 233, + "Positive %": 1.762, + "Num Positive per mm^2": 114.14 + } +} \ No newline at end of file diff --git a/660/TumorCenter_CD8_block14_x2_y10_patient660_1.json b/660/TumorCenter_CD8_block14_x2_y10_patient660_1.json new file mode 100644 index 0000000000000000000000000000000000000000..662938b9ba5192710ba43f88b4ed5a844eaca1cc --- /dev/null +++ b/660/TumorCenter_CD8_block14_x2_y10_patient660_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 25486.5, + "Num Detections": 9369, + "Num Negative": 9189, + "Num Positive": 180, + "Positive %": 1.921, + "Num Positive per mm^2": 114.31 + } +} \ No newline at end of file diff --git a/660/history_text.txt b/660/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f68b024472dfddb5f05e01e9a61becb553f71e5a --- /dev/null +++ b/660/history_text.txt @@ -0,0 +1 @@ +Four-year history of a mass on the right edge of the tongue. Since <2014> the mass has progressed in size. A biopsy was taken <2014>. This showed an inflammatory altered papillomatosis, structured squamous cell hyperplasia with fungal colonization, without evidence of infiltrative tumor growth. In addition, several unclear nodules in both lobes of the thyroid gland. Now indication for the above-mentioned operation. \ No newline at end of file diff --git a/660/icd_codes.txt b/660/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..23f55a455cfcf5bd2b8a62d6b2bafd4eb6600b6d --- /dev/null +++ b/660/icd_codes.txt @@ -0,0 +1 @@ +Unsichere Neubildung des seitlichen Zungenrandes[D37.0 R] Nichttoxische mehrknotige Struma[E04.2 B] \ No newline at end of file diff --git a/660/ops_codes.txt b/660/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..db76e25579592428ce3cc26d277fa3329e67a5f6 --- /dev/null +++ b/660/ops_codes.txt @@ -0,0 +1 @@ +Zungentumorexzision[5-250.2 ] Plastische Rekonstruktion Zunge[5-253.1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Punktion der Schilddrüse[1-859.0 ] \ No newline at end of file diff --git a/660/patient_clinical_data.json b/660/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5216d7fc6c5b292b156470acb7075c40a35b4d3d --- /dev/null +++ b/660/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 66, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 1, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/660/patient_pathological_data.json b/660/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..254af8a7461a79f508db21a42eefbc94e5647491 --- /dev/null +++ b/660/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "660", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 17, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/660/surgery_description.txt b/660/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..488252873b7644dddfa09a126f5c934f96ed8081 --- /dev/null +++ b/660/surgery_description.txt @@ -0,0 +1 @@ +Resection, Plastic reconstruction, and Panendoscopy diff --git a/660/surgery_report.txt b/660/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a9d890d85f4956a546631697c9174d4b5d094fbb --- /dev/null +++ b/660/surgery_report.txt @@ -0,0 +1 @@ +After induction of anaesthesia by the anaesthetist, a rigid tracheobronchoscopy is performed: here, the mucous membrane and anatomical conditions in the area of the larynx and trachea are inconspicuous. Then intubation by the surgeon and head positioning. Insertion of the gastroscope under constant air insufflation into the stomach. Inspection of the stomach. The mucosa is found to be free of irritation. Withdrawal of the esophagoscope with constant air insufflation and inspection of the esophagus. Inconspicuous linea serrata at the esophagogastric junction and inconspicuous mucosal conditions up to the esophageal entrance. Removal of the gastroscope. Insertion of the size B small bore tube. Inspection of the base of the tongue, vallecula and both tonsils revealed unremarkable anatomical conditions. Advancement of the small bore tube to the right piriform sinus and via the retrocricoidal area into the left piriform sinus. The mucosal conditions here are also unremarkable. Inspection of the endolarynx: No evidence of a suspicious mass. Removal of the small drainage tube while preserving the mucosa. Insertion of the Jennings mouth retractor. Inspection of the oral vestibule and oral cavity: An oval, broad-based, verrucous, exophytic, rough mass measuring 4.5 x 3.5 cm was found on the edge and undersurface of the tongue, starting on the right from the tip of the tongue to the second premolar tooth. On palpation, the mass grew minimally into the tongue musculature. After consultation with , a decision is made to perform a trial excision. A trial excision is made at a distance of 0.3 mm from the edge of the tumor. Targeted bipolar coagulation of the irradiating blood vessels. Further dissection caudally until the lingual nerve is identified. The lingual nerve extends into the mass, making transection necessary. Further gentle conditions in the area of the sublingual curcule and preservation of the Wharton's duct. After resection, demonstration on . Decision on primary wound closure. A circular marginal sample 0.3 mm wide is taken, marked and sent for histological analysis. Another thin sample was taken from the tip of the tongue. Primary defect closure. Positioning of the patient for gross needle puncture: sterile washing and covering of the surgical site. Preparation of the gross needle puncture set. Identification of the largest nodule in the right lobe of the thyroid gland. Incision of the skin through . A coarse needle puncture (4x) of the largest nodule, cranial pole of the right thyroid lobe is performed under ultrasound guidance. Hemostasis by means of short-lasting compression and wound dressing. The surgical procedure was completed without complications. Conclusion: A trial excision of the broad-based, verrucous, exophytically growing tumor at the base of the tongue/under the tongue on the right is performed. Primary closure of the defect with preservation of the Wharton's duct. Gross needle aspiration of the largest nodule in the cranial pole of the right scabrous gland. Further procedure after receipt of the histology. Postoperative antibiotic treatment with Unacid 3x3 g and Clont 3x 500 mg should be continued for the next three days. Soft food, analgesics if required. \ No newline at end of file diff --git a/661/InvasionFront_CD3_block12_x3_y4_patient661_0.json b/661/InvasionFront_CD3_block12_x3_y4_patient661_0.json new file mode 100644 index 0000000000000000000000000000000000000000..daccd496a146d954632a93c7affc6ba83ba2e8ac --- /dev/null +++ b/661/InvasionFront_CD3_block12_x3_y4_patient661_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11718.8, + "Centroid Y µm": 14592.3, + "Num Detections": 18665, + "Num Negative": 17947, + "Num Positive": 718, + "Positive %": 3.847, + "Num Positive per mm^2": 294.23 + } +} \ No newline at end of file diff --git a/661/InvasionFront_CD3_block12_x4_y4_patient661_1.json b/661/InvasionFront_CD3_block12_x4_y4_patient661_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b18ca72ae7045ed9bf0ee16f771183bdd7003e64 --- /dev/null +++ b/661/InvasionFront_CD3_block12_x4_y4_patient661_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 14842.1, + "Num Detections": 20577, + "Num Negative": 18515, + "Num Positive": 2062, + "Positive %": 10.02, + "Num Positive per mm^2": 798.44 + } +} \ No newline at end of file diff --git a/661/InvasionFront_CD8_block12_x3_y4_patient661_0.json b/661/InvasionFront_CD8_block12_x3_y4_patient661_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d731156fdbe59198b13c195f90678417fb036416 --- /dev/null +++ b/661/InvasionFront_CD8_block12_x3_y4_patient661_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11793.8, + "Centroid Y µm": 13717.7, + "Num Detections": 22017, + "Num Negative": 21409, + "Num Positive": 608, + "Positive %": 2.762, + "Num Positive per mm^2": 236.86 + } +} \ No newline at end of file diff --git a/661/InvasionFront_CD8_block12_x4_y4_patient661_1.json b/661/InvasionFront_CD8_block12_x4_y4_patient661_1.json new file mode 100644 index 0000000000000000000000000000000000000000..471da213b137e24dda1b4d846732cb26b2e587d9 --- /dev/null +++ b/661/InvasionFront_CD8_block12_x4_y4_patient661_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14467.3, + "Centroid Y µm": 13567.8, + "Num Detections": 20715, + "Num Negative": 19493, + "Num Positive": 1222, + "Positive %": 5.899, + "Num Positive per mm^2": 468.55 + } +} \ No newline at end of file diff --git a/661/TumorCenter_CD3_block12_x3_y4_patient661_0.json b/661/TumorCenter_CD3_block12_x3_y4_patient661_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d069bfcb681c547a9dc4af2b52039db9b10fad9 --- /dev/null +++ b/661/TumorCenter_CD3_block12_x3_y4_patient661_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 9969.7, + "Num Detections": 19874, + "Num Negative": 19229, + "Num Positive": 645, + "Positive %": 3.245, + "Num Positive per mm^2": 260.52 + } +} \ No newline at end of file diff --git a/661/TumorCenter_CD3_block12_x4_y4_patient661_1.json b/661/TumorCenter_CD3_block12_x4_y4_patient661_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91c234b43972631d364161141595c23314fa47ee --- /dev/null +++ b/661/TumorCenter_CD3_block12_x4_y4_patient661_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 9894.8, + "Num Detections": 21546, + "Num Negative": 20541, + "Num Positive": 1005, + "Positive %": 4.664, + "Num Positive per mm^2": 399.31 + } +} \ No newline at end of file diff --git a/661/TumorCenter_CD8_block12_x3_y4_patient661_0.json b/661/TumorCenter_CD8_block12_x3_y4_patient661_0.json new file mode 100644 index 0000000000000000000000000000000000000000..096433d40d29cff4423a253aa839d32bcf142bbe --- /dev/null +++ b/661/TumorCenter_CD8_block12_x3_y4_patient661_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14223.7, + "Centroid Y µm": 19356.1, + "Num Detections": 15868, + "Num Negative": 15826, + "Num Positive": 42, + "Positive %": 0.2647, + "Num Positive per mm^2": 16.9 + } +} \ No newline at end of file diff --git a/661/TumorCenter_CD8_block12_x4_y4_patient661_1.json b/661/TumorCenter_CD8_block12_x4_y4_patient661_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0553027014be2504a8e574649d52598f96df8163 --- /dev/null +++ b/661/TumorCenter_CD8_block12_x4_y4_patient661_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16960.4, + "Centroid Y µm": 19438.9, + "Num Detections": 19315, + "Num Negative": 19107, + "Num Positive": 208, + "Positive %": 1.077, + "Num Positive per mm^2": 83.96 + } +} \ No newline at end of file diff --git a/661/history_text.txt b/661/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..11110b17736d6df1d7022784783345e85fd43957 --- /dev/null +++ b/661/history_text.txt @@ -0,0 +1 @@ +A cT1 to cT2 cN2c tonsillar carcinoma was confirmed in the patient <2011> as part of a panendoscopy. Now indication for surgical therapeutic resection transorally, depending on the intraoperative extent with flap coverage. \ No newline at end of file diff --git a/661/icd_codes.txt b/661/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/661/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/661/ops_codes.txt b/661/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb9e63db71b4c01dc155f8870122a31e643bdd7c --- /dev/null +++ b/661/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Transplantat[5-296.14 ] Transorale radikale Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut aus der Genitalregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] \ No newline at end of file diff --git a/661/patient_clinical_data.json b/661/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7692a582cb06892e6bac1d09e6e1fb388824491c --- /dev/null +++ b/661/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 44, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/661/patient_pathological_data.json b/661/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7c2714940e93e2462e8f4fa9f06d1d3c4d67287e --- /dev/null +++ b/661/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "661", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2a", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Acantholytic", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/661/surgery_description.txt b/661/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2738c85424b72f7a88158b3501638e91e78cff1f --- /dev/null +++ b/661/surgery_description.txt @@ -0,0 +1 @@ +Pharyngectomy, Free flap (Radial) diff --git a/661/surgery_report.txt b/661/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..640b39dff0e22995b03fdda10614701619a48297 --- /dev/null +++ b/661/surgery_report.txt @@ -0,0 +1 @@ +Initially start with PEG insertion: For this purpose, insertion with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. If the diaphanoscopy is excellent, the stomach is punctured without any problems and the PEG tube is inserted using the usual thread pull-through method. Inspection of the oesophagus during reflection, inconspicuous conditions here. Now insertion with the small water tube, later supported with the TE blocker. A whitish, coarse, exophytic tumor of the right tonsil is seen, which clearly extends caudally, spreads to the posterior palatal arch in the lower half and leaves the tonsil lobe caudally and grows onto the oropharyngeal side wall up to the border of the hypopharyngeal side wall. Growth over the glossotonsillar groove circumscribed to the base of the tongue. Here also circumscribed infiltration of the base of the tongue. Posterior pharyngeal wall and soft palate are free. Now demonstration of findings on and . Due to the extent, confirmation of the indication for radial flap coverage, combined resection transorally and transcervically due to the growth. Start now with transoral resection: Initially transoral resection as for tumor TE, including the anterior palatal arch. Good overview. Exclusion of growth towards the pterygoid muscles. The posterior palatal arch can be well preserved cranially. Resection to parauvular. Here, however, no resection of the soft palate. Caudal removal of the posterior palatal arch. Now resection of the part of the glossotonsillar groove with complete removal of the glossotonsillar groove. Resection of the base of the tongue. Here, however, further resection of the base of the tongue transcervically for a better overview. Now carry out covering edge samples in the area of the soft palate, the posterior palatal arch and the buccal transition. These are completely tumor-free in the frozen section examination. Therefore, repositioning for neck dissection and completion of the tumor resection. Curved skin incision on the front edge of the sternocleidomastoid muscle on the right side after injection of xylocaine with adrenaline. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma and creation of a platysma flap. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digastric muscle and the submandibular gland. Palpation of 2 coarse lymph nodes level II/III located in the area of the jugulofacial angle, certainly without infiltration of the sternocleidomastoid muscle. Clearing of the anterior neck preparation with preservation of the superior thyroid and the facial vein, which is very pronounced here. Free preparation of the internal jugular vein. Difficult preparation conditions in the area of the metastasis. Exposure of the accessorius nerve. Protection and preservation of the nerve. Difficult preparation conditions in the area of the metastases in the area of the internal jugular vein. Certainly no infiltration here, but vulnerable vascular conditions and two tears. Suture and ligature, but with preservation of continuity of the vein. Clearing of the accessorius triangle and level V with careful protection of the cervical plexus. Removal of the neck preparation en bloc. Now also evacuation of level Ib with infiltration of the glossotonsillar groove close to the posterior floor of the mouth. Subcapsular dissection of the submandibular gland. Extirpation of several lymph nodes measuring up to 1.5 cm. Removal of the gland. Final palpation. In free conditions, resection of the digastric muscle with planned flap coverage. Now orientate the digastric muscle at the posterior upper edge of the hyoid. Entering the oral cavity in the area of the posterior floor of the mouth. Widening of the pharyngotomy. Exposure of the resected edge of the tongue and the lateral wall of the pharynx. Now a good overview of the remaining tumor. Resection of the tumor in the area of the base of the tongue generously with circumscribed nodular infiltration in the area of the base of the tongue. Widening of the muscle cuff and later removal of a marginal sample. Resection of the tumor. Inspection. Findings demo to . It can now be seen that the tumor in the area of the caudal pharyngeal wall is somewhat narrowly resected macroscopically on the specimen, as well as at the site in the area of the base of the tongue, where the safety margin was already widened during dissection. A generous resection is now taken at both sites together with the thread-marked main preparation and sent for frozen section diagnostics. Here, the tumor is classified as R0 on the specimen, but with narrow resection margins in the area of the caudal pharyngeal wall and in the area of the tongue. However, the resections here are completely tumor-free, meaning that the resection is R0 overall. Now measuring the graft. A 9 x 7 cm graft is later lifted, taking into account the resection area on the tongue and the resection of the glossotonsillar groove. Now continue to perform the neck dissection on the right side in parallel and remove the radialis graft in the area of the left forearm. First perform the neck dissection. Skin incision and cutting of skin and subcutaneous tissue. Dissection of the platysma. Exposure of the sternocleidomastoid muscle. Exposure of the external jugular vein and the auricular nerve. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Exposure of the digastric muscle. Release of the anterior neck preparation with careful protection of the cervical artery of the superior thyroid artery and the facial vein. Exposure of the accessorius nerve. Free preparation of the internal jugular vein. Here, several lymph nodes that are macroscopically conspicuous in size and number, which are not yet primarily metastatic. Clearing of the accessorius triangle and level V with careful protection of the accessorius nerve and the cervical plexus branches. Final check. Irrigation of the wound. In dry conditions, insertion of a 10-gauge Redon drain and two-layer wound closure. Now to lift the radial implant. After applying the tourniquet and marking the graft, cut around it while lifting a skin monitor. Expose the cephalic vein to take the vein with you. Perform the Hayden maneuver and expose the superficial radial nerve ramus. Exposure of the distal vascular pedicle strictly subfascial to the dissection. Ligation of the pedicle. Further meticulous sufascial dissection with clipping of distal vessels close to the stalk. A relatively high brachial artery with a very strong ulnar artery can now be seen in the crook of the elbow. This is visualized and preserved. The proximal radial artery stump is relatively weak. Exposure of the outlet of the interosseous artery. This is preserved. Exposure of the venous bridge between the deep radial system and the cephalic vein, which is strongly pronounced. Separation of the veins while carefully preserving the bridge. Reopening of the tourniquet and minute hemostasis. Excellent flap vitality and after hemostasis removal of the graft after ligation of the radial artery with preservation of the interosseous artery and removal of the cephalic vein. In the meantime, the tracheotomy was also performed. Horizontal skin incision for this. Cut through the skin and subcutaneous tissue. Exposure of the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the thyroid isthmus. Ligation of the isthmus and transection. Exposure of the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap and insertion of the tracheostoma in the usual manner. Finally, easy transfer to an 8 mm tracheoflex cannula and suturing of the same. Now, first of all, placement of sutures transcervically in the area of the base of the tongue and in the area of the caudal pharyngeal wall. First incorporate the graft transorally. This works well. Good fit. Reconstruction of the anterior palatal arch, glossotonsillar groove and lateral pharyngeal wall. Further transzevical incorporation. Suturing in the area of the vallecula, the base of the tongue and the pharyngeal side wall under moderate tension. Now placement of the vascular pedicle. Suture the skin monitor caudally with a very long vascular pedicle. Exposure of the superior thyroid artery. The superior thyroid artery must now be shortened several times in order to achieve a thickness of approximately the same caliber. However, the vessel is very tortuous, and despite multiple positioning of the Acland clamps and the vascular pedicle, the angulation is unfavorable. Therefore extremely difficult anastomization conditions. Performing an anastomosis with 8.0 Ethilon. Finally, regular anastomization despite extremely difficult conditions. After reopening the clamps, regular venous return and good flap vitality. Now, after vascular preparation of the facial vein and the radial vein, perform the venous anastomosis with a size 4 coupler. This works well with a strong radial vessel and a very strong facial vein. Immediate good blood circulation and regular vitality. Overall, however, a tendency to displacement due to the long course of the vessel or stalk. Therefore careful placement. Careful two-layer wound closure. During the final check, a pale graft is noticed which does not bleed after puncture. Therefore the decision is made to reopen the neck in case of arterial problems. Visualization of the arterial anastomosis with macroscopically normal venous anastomosis. There is no longer a transmitted pulse. The artery is therefore removed. A thrombus is now visible. Despite removal of the thrombus and repeated flushing, there is no more arterial bleeding. Therefore, this vessel is removed and an arterial anastomosis is performed again. Careful dissection. The facial artery was already removed during tumor dissection. Now expose a somewhat cranially located vascular outlet, most likely corresponding to the ascending pharyngeal artery and macroscopically largely equivalent in caliber. Exposure of the vessel. Intermediate involvement of . Now renewed vessel anastomization with 8.0 ethilon. Again, difficult suturing conditions due to the position of the vessel. Finally, however, regular flow, immediately good venous filling and regular flap vitality. Now, with regular vitality, wound closure in two layers. Final check and no further measures and transfer of the patient to the intensive care unit. A 10 x 6 cm full-thickness skin graft had already been removed from the right groin. Cutaneous preparation, mobilization of the subcutaneous tissue, careful two-layer wound closure after insertion of a 10 Redon drainage and finally careful incorporation of the full-thickness skin graft into the forearm. Two-layer wound closure and final application of a vacuum dressing and termination of the procedure at this point. Conclusion: Intraoperative cT3 cN2b oropharyngeal carcinoma on the left with intraoperative R0 resection. Defect coverage using a radialis graft with difficult anastomization conditions due to the vessel position and the length of the stalk. Meticulous flap control postoperatively. On the 8th postoperative day, an X-ray pumice should be taken. If the flap conditions are intact, the patient can then be gradually fed and decannulated, depending on the swallowing function. The patient received intraoperative intravenous antibiotics of Unacid and a single dose of 250 mg SDH. After receiving the histology, presentation at our interdisciplinary tumor conference to plan the adjuvant therapy. \ No newline at end of file diff --git a/662/InvasionFront_CD3_block13_x5_y5_patient662_0.json b/662/InvasionFront_CD3_block13_x5_y5_patient662_0.json new file mode 100644 index 0000000000000000000000000000000000000000..90d001e6d5e877ccbfbc3b5e3844974963a579d5 --- /dev/null +++ b/662/InvasionFront_CD3_block13_x5_y5_patient662_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 11743.8, + "Num Detections": 23599, + "Num Negative": 22926, + "Num Positive": 673, + "Positive %": 2.852, + "Num Positive per mm^2": 270.62 + } +} \ No newline at end of file diff --git a/662/InvasionFront_CD3_block13_x6_y5_patient662_1.json b/662/InvasionFront_CD3_block13_x6_y5_patient662_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a0f4ade8c4b2fa820f33f96c56dd35f31638438 --- /dev/null +++ b/662/InvasionFront_CD3_block13_x6_y5_patient662_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 11743.8, + "Num Detections": 21240, + "Num Negative": 20523, + "Num Positive": 717, + "Positive %": 3.376, + "Num Positive per mm^2": 299.41 + } +} \ No newline at end of file diff --git a/662/InvasionFront_CD8_block13_x5_y5_patient662_0.json b/662/InvasionFront_CD8_block13_x5_y5_patient662_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aceac86fd29289f9a8553a984d88e44cacaa681d --- /dev/null +++ b/662/InvasionFront_CD8_block13_x5_y5_patient662_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 13617.8, + "Num Detections": 24674, + "Num Negative": 24342, + "Num Positive": 332, + "Positive %": 1.346, + "Num Positive per mm^2": 130.74 + } +} \ No newline at end of file diff --git a/662/InvasionFront_CD8_block13_x6_y5_patient662_1.json b/662/InvasionFront_CD8_block13_x6_y5_patient662_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b7d7aa124b676758a8f624f49345b492dce0984d --- /dev/null +++ b/662/InvasionFront_CD8_block13_x6_y5_patient662_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19914.5, + "Centroid Y µm": 13767.7, + "Num Detections": 21678, + "Num Negative": 21419, + "Num Positive": 259, + "Positive %": 1.195, + "Num Positive per mm^2": 106.36 + } +} \ No newline at end of file diff --git a/662/TumorCenter_CD3_block13_x5_y5_patient662_0.json b/662/TumorCenter_CD3_block13_x5_y5_patient662_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac2601563f5fce082453eda4d07f3567659948ee --- /dev/null +++ b/662/TumorCenter_CD3_block13_x5_y5_patient662_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17190.9, + "Centroid Y µm": 19214.8, + "Num Detections": 22921, + "Num Negative": 21740, + "Num Positive": 1181, + "Positive %": 5.152, + "Num Positive per mm^2": 478.35 + } +} \ No newline at end of file diff --git a/662/TumorCenter_CD3_block13_x6_y5_patient662_1.json b/662/TumorCenter_CD3_block13_x6_y5_patient662_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eb8f88c9975e76ea8c367bcbe5f97693f7d23a0b --- /dev/null +++ b/662/TumorCenter_CD3_block13_x6_y5_patient662_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19689.6, + "Centroid Y µm": 19389.7, + "Num Detections": 22794, + "Num Negative": 20958, + "Num Positive": 1836, + "Positive %": 8.055, + "Num Positive per mm^2": 708.99 + } +} \ No newline at end of file diff --git a/662/TumorCenter_CD8_block13_x5_y5_patient662_0.json b/662/TumorCenter_CD8_block13_x5_y5_patient662_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e5216da65e11bb83c9b59c9f92bf35025d5f2491 --- /dev/null +++ b/662/TumorCenter_CD8_block13_x5_y5_patient662_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 11993.6, + "Num Detections": 21901, + "Num Negative": 21747, + "Num Positive": 154, + "Positive %": 0.7032, + "Num Positive per mm^2": 65.09 + } +} \ No newline at end of file diff --git a/662/TumorCenter_CD8_block13_x6_y5_patient662_1.json b/662/TumorCenter_CD8_block13_x6_y5_patient662_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c4271b093ac7ca497b71ffa81e2581bbe84af7c9 --- /dev/null +++ b/662/TumorCenter_CD8_block13_x6_y5_patient662_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 11718.8, + "Num Detections": 25830, + "Num Negative": 24960, + "Num Positive": 870, + "Positive %": 3.368, + "Num Positive per mm^2": 329.37 + } +} \ No newline at end of file diff --git a/662/history_text.txt b/662/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6bd5f2a8857c0a1f237d6d778433e33696ac2d0a --- /dev/null +++ b/662/history_text.txt @@ -0,0 +1 @@ +Patient with an unclear polypous mass in the right nasal cavity or sinus with a mass visible on CT. PE from this area therefore indicated with frozen section diagnostics. In addition, the main diagnosis of hypopharyngeal carcinoma on the left was confirmed as squamous cell carcinoma. Pre-panendoscopy revealed the carcinoma in the area of a part of the left lateral wall, left anterior wall, lateral left aryepiglottic fold. Clinical and CT infiltration of the tumor in the space between the arytenoid cartilage, thyroid cartilage and cricoid cartilage. Laryngectomy therefore also indicated. \ No newline at end of file diff --git a/662/icd_codes.txt b/662/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..bc44def61595b42222cda038426a37befcac967a --- /dev/null +++ b/662/icd_codes.txt @@ -0,0 +1 @@ +Polyposis nasi et sinuum[J33.8 R] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 L] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/662/ops_codes.txt b/662/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d372cf212aabb2a7b5d1af7e6822f4bce91109d --- /dev/null +++ b/662/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Probeexzision an der Nase onA[1-539 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/662/patient_clinical_data.json b/662/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ce60d61671ab035111423e50ba300efc76a7ecd9 --- /dev/null +++ b/662/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/662/patient_pathological_data.json b/662/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fd2608f5040d1bdb1d8ddbc0cb63503e24d866dd --- /dev/null +++ b/662/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "662", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 45, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/662/surgery_description.txt b/662/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c07d937db0b1a662980bb2b745881d5785ce669e --- /dev/null +++ b/662/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, PEG placement, Tracheotomy diff --git a/662/surgery_report.txt b/662/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..8a292cfcb6364db998af6e1b1d0b97fc53250b33 --- /dev/null +++ b/662/surgery_report.txt @@ -0,0 +1 @@ +Transfer of the patient to the operating theater. Introductory consultation with the anesthesia department. Team time-out. Positioning of the head and start of biopsy endonasal nasal inspection: positioning of the patient's head by the surgeon. Insertion of high inserts, which are removed again before the operation begins. There is a deviated septum to the right. The nasal cavity is adjusted with the speculum, initially inconspicuous conditions. Now enter the nasal cavity on the right side with 45° optics and lateralize the inferior turbinate. Careful medialization of the middle turbinate without fracturing it. A polypous mucosa is seen in the area of the middle nasal passage, which is resected with the blunt Blakesley. In addition, the middle turbinate is polypous and distended. The lateral part of the middle turbinate is carefully resected with the sharp Blakesley. The middle turbinate is not fractured. Overall, macroscopically non-suspicious conditions. The removed sample is sent to the pathology department for frozen section examination. After consultation with , it is an inflammatory polyp with no evidence of malignancy. Now completion of nasal inspection without complications or bleeding. Repositioning of the patient for pharyngoscopy and laryngoscopy: Insertion of the small bore tube size C and D again after insertion of a mouth guard. The described exophytic tumor can be seen, which runs laterally from the anterior area of the left lateral wall over the anterior wall to the area of the arytenoid fold and extends here to the arytenoid cartilage. Thickening at the back in the area between the arytenoid cartilage, cricoid cartilage and thyroid cartilage. Tumor infiltration can also be seen here on CT, which ultimately leads to the indication for laryngectomy. Initial PEG placement: adjustment of the esophageal inlet. Careful advancement with the flexible gastroesophagoscope into the stomach. Inspection of all sections of the stomach, which are unremarkable. Now perform the positive diaphanoscopy and insert the PEG tube in the usual manner using the thread pull-through method. Subsequent repositioning for laryngectomy and neck dissection on both sides: also cover the left forearm if radial flap is necessary. First of all, positioning and neck dissection on both sides. Neck dissection on the right: skin incision and dissection through the subcutaneous fatty tissue. Subplatysmal dissection of the apron flap. Exposure of the anterior border of the sternocleidomastoid muscle and discovery of the accessorius nerve. Now expose the omohyoid muscle and expose the medial edge. Dissect the submandibular gland and expose the posterior venter of the digastric muscle, sparing the marginal ramus until posterior to level IIb. Now open the cervical vascular sheath and expose the internal jugular vein and the facial vein. Protection of the cervical sinus and the hypoglossal nerve in the jugulofacial angle. Displacement and, at the end of the operation, re-embedding of the hypoglossal nerve in the sense of a neurolysis. Clearing of level IIb, the accessorius nerve is unusually high here, but can be spared without any problems. Displacement and, at the end of the operation, re-embedding of the accessory nerve in the sense of a neurolysis. Removal of the lateral neck preparation while sparing the brachial plexus, the common carotid artery and the vagus nerve. Displacement and, at the end of the operation, re-embedding of the vagus nerve in the sense of a neurolysis. Careful dissection of the caudal margin and careful hemostasis using bipolar coagulation. Now also removal of the medial neck preparation. Neck dissection on the left: Positioning of the patient by the surgeon in a slightly reclined position. Injection of Suprarenin in the area of the skin incision. Now mark the skin incision and cut through the cutaneous-subcutaneous tissue. An apron flap is selected for the incision. Now cut through the platysma and subplatysmal dissection of the apron flap until the submandibular gland is exposed on both sides just above the hyoid bone. Approximation of the apron flap and identification of the anterior border of the sternocleidomastoid muscle. Identification of the omohyoid muscle. Now dissection along the sternocleidomastoid muscle into the depths, exposing and sparing the branches of the cervical plexus. Now also identification of the accessorius nerve. Identification at the cranial end of the posterior venter of the digastric muscle and careful release of the neck dissection onto the muscle. Exposure of the accessorius nerve and protection of the nerve. Displacement and at the end of the operation re-embedding of the accessorius nerve in the sense of a neurolysis. Now dissection medially along the cervical vascular nerve sheath and detachment of the neck preparation from the cervical vascular nerve sheath. Then detachment of the neck preparation in regions II to IV while preserving the neuronal and vascular structures. Then laryngectomy and partial pharyngeal resection on the left: First dissection of the infrahyoid muscles from the hyoid bone. Fat and lymph node tissue, which lies in front of the infrahyoid musculature, is sent in separately as neck dissection level VI. Infrahyoid musculature is dissected and cut caudally. The superior cornu is released on the right, the constrictor is dissected. This is not possible on the left due to the tumor location. The thyroid gland is dissected caudolaterally on both sides, with a remnant still present on the right. In the isthmus area, a small, harder nodule is seen, which is also removed on the way to removal of the larynx. The left thyroid gland remnant with the cranial cystic mass is not touched and is dissected caudolaterally. The suprahyoid muscles are then dissected from the hyoid bone and beaten caudally with pre-epiglottic fatty tissue. Entering the pharynx, grasping the epiglottis. Successive detachment of the mucosa, which was previously dissected from the inside of the thyroid cartilage on the right side to preserve the piriform sinus. From the left side, the tumor is now cut around under direct vision with a safety margin of at least 1.5 cm on all sides. This ultimately results in a partial pharyngeal resection that extends to the tip of the piriform sinus, but not quite to the end of the tip of the piriform sinus. The larynx is removed caudally, whereby the maximum mucosal width is also preserved postcricoidally. The larynx is finally removed caudally together with the tumor. Prior to this, a tracheotomy is created between the 1st and 2nd intercartilaginous spaces and re-intubation. Finally, the larynx is removed. Tumor with surrounding mucosa is marked with a suture. A marginal sample is taken from the left-lateral pharyngeal region, which is thread-marked and sent to the frozen section. There is still a small tumor nest in the frozen section towards the cranial side. Therefore, a resection is performed in the base of the tongue and cranial-lateral pharyngeal wall area, followed by removal of a marginal sample from this area. No more tumor in the marginal sample. Thus now R0 status. Assessment of the remaining pharynx. This can still be sutured well without becoming too tight. To improve the passage, after further dissection of the thyroid gland on the left side, a myotomy is performed in the area of the cricopharyngeal muscle and constrictor pharyngis laterally up to the mucosa. Length approx. 3 - 3.5 cm caudally. Subsequent insertion of an 8 mm Provox prosthesis at the typical site without complications. Then closure of the pharynx with the first layer of mucosa-inverting sutures using 4-0 or 3-0 Vicryl single-button sutures. A further layer is placed over this, also inverting with 4-0 or 3-0 Vicryl single button sutures. A third layer can be sutured in the caudal and cranial region, which is not possible in the medial part due to the resection of the hypopharyngeal muscle. The nasogastric tube inserted at the beginning of the operation serves as a splint. The remainder of the infrahyoid musculature is sutured caudally via the pharyngo-oesophageal junction. The site is then irrigated and the bleeding carefully stopped. No bleeding at the end of the operation. Layered closure of the neck wound with insertion of a Redon drain on both sides and epithelialization of the tracheostoma. Insertion of a 9 mm tracheostomy tube. Application of a pressure bandage. Completion of the procedure without complications. Final consultation with the anesthesiologist. Patient is extubated and transferred to the intensive care unit for monitoring for 1 - 2 days. Overall cT4a hypopharyngeal carcinoma, whereby not the tumor size but the infiltration into the region between the arytenoid cartilage, cricoid cartilage and thyroid cartilage was decisive for the indication for laryngectomy. Please continue postoperative antibiotics with Unacid as already started intraoperatively. Feeding via the inserted PEG tube for 10 days, then X-ray pre-swallow and, if necessary, diet build-up. Wait for the final histology and discuss the further procedure in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/663/InvasionFront_CD3_block2_x5_y1_patient663_0.json b/663/InvasionFront_CD3_block2_x5_y1_patient663_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d95cb381f195ec2bab98d131a267e4b30d355130 --- /dev/null +++ b/663/InvasionFront_CD3_block2_x5_y1_patient663_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 16041.5, + "Num Detections": 26060, + "Num Negative": 24778, + "Num Positive": 1282, + "Positive %": 4.919, + "Num Positive per mm^2": 531.98 + } +} \ No newline at end of file diff --git a/663/InvasionFront_CD3_block2_x6_y1_patient663_1.json b/663/InvasionFront_CD3_block2_x6_y1_patient663_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0605dc0218ce96e619975aaee73f2e6f26e38a9e --- /dev/null +++ b/663/InvasionFront_CD3_block2_x6_y1_patient663_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21613.6, + "Centroid Y µm": 16291.4, + "Num Detections": 8846, + "Num Negative": 8462, + "Num Positive": 384, + "Positive %": 4.341, + "Num Positive per mm^2": 473.94 + } +} \ No newline at end of file diff --git a/663/InvasionFront_CD8_block2_x5_y1_patient663_0.json b/663/InvasionFront_CD8_block2_x5_y1_patient663_0.json new file mode 100644 index 0000000000000000000000000000000000000000..108d55d9514001524be177bef1bb89e6900c0f0a --- /dev/null +++ b/663/InvasionFront_CD8_block2_x5_y1_patient663_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17690.6, + "Centroid Y µm": 3523.1, + "Num Detections": 26347, + "Num Negative": 23341, + "Num Positive": 3006, + "Positive %": 11.41, + "Num Positive per mm^2": 1229.8 + } +} \ No newline at end of file diff --git a/663/InvasionFront_CD8_block2_x6_y1_patient663_1.json b/663/InvasionFront_CD8_block2_x6_y1_patient663_1.json new file mode 100644 index 0000000000000000000000000000000000000000..627bcc51537d690ae0943c5fdfeccc7e047c530e --- /dev/null +++ b/663/InvasionFront_CD8_block2_x6_y1_patient663_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20339.2, + "Centroid Y µm": 3897.9, + "Num Detections": 7883, + "Num Negative": 7614, + "Num Positive": 269, + "Positive %": 3.412, + "Num Positive per mm^2": 333.29 + } +} \ No newline at end of file diff --git a/663/TumorCenter_CD3_block2_x5_y1_patient663_0.json b/663/TumorCenter_CD3_block2_x5_y1_patient663_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1bcef3f4f24280367fd90aaabfafee1722a647a1 --- /dev/null +++ b/663/TumorCenter_CD3_block2_x5_y1_patient663_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16741.1, + "Centroid Y µm": 2423.7, + "Num Detections": 21814, + "Num Negative": 19948, + "Num Positive": 1866, + "Positive %": 8.554, + "Num Positive per mm^2": 861.15 + } +} \ No newline at end of file diff --git a/663/TumorCenter_CD3_block2_x6_y1_patient663_1.json b/663/TumorCenter_CD3_block2_x6_y1_patient663_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b2165ef2ad7fe57dedac3e0126b6fc4dd32d9748 --- /dev/null +++ b/663/TumorCenter_CD3_block2_x6_y1_patient663_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19164.9, + "Centroid Y µm": 2373.7, + "Num Detections": 14688, + "Num Negative": 13655, + "Num Positive": 1033, + "Positive %": 7.033, + "Num Positive per mm^2": 690.03 + } +} \ No newline at end of file diff --git a/663/TumorCenter_CD8_block2_x5_y1_patient663_0.json b/663/TumorCenter_CD8_block2_x5_y1_patient663_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d0fc39936b775e5d5506396944564b51d43cd411 --- /dev/null +++ b/663/TumorCenter_CD8_block2_x5_y1_patient663_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17790.6, + "Centroid Y µm": 1974.0, + "Num Detections": 23141, + "Num Negative": 21193, + "Num Positive": 1948, + "Positive %": 8.418, + "Num Positive per mm^2": 912.96 + } +} \ No newline at end of file diff --git a/663/TumorCenter_CD8_block2_x6_y1_patient663_1.json b/663/TumorCenter_CD8_block2_x6_y1_patient663_1.json new file mode 100644 index 0000000000000000000000000000000000000000..87c3bcaf885d9fcf61a8c67718de3ec0e4c66e85 --- /dev/null +++ b/663/TumorCenter_CD8_block2_x6_y1_patient663_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20214.3, + "Centroid Y µm": 1824.0, + "Num Detections": 17289, + "Num Negative": 16403, + "Num Positive": 886, + "Positive %": 5.125, + "Num Positive per mm^2": 532.37 + } +} \ No newline at end of file diff --git a/663/history_text.txt b/663/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ba4c36e90a2c3d88b15651ec79a8402f2c8c69eb --- /dev/null +++ b/663/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: The patient has a large mass in the area of the left pharyngeal duct, which grows exophytically and extends from the lower tonsillar pole to the piriform sinus in the area of the lateral pharyngeal wall without reaching the tip of the piriform sinus. \ No newline at end of file diff --git a/663/icd_codes.txt b/663/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..01a63f01512e7f540819af61bc8589edc9753a09 --- /dev/null +++ b/663/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 ] \ No newline at end of file diff --git a/663/ops_codes.txt b/663/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..22406bb8ed6eff932e92783a20001ce8fd235a6b --- /dev/null +++ b/663/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagoskopie mit flexiblem Instrument[1-630.0 ] Laserkoagulation Gewebe Gaumen- und Rachenmandel[5-289.01 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] \ No newline at end of file diff --git a/663/patient_clinical_data.json b/663/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..955c160bc75be7024a017006dafb0f72a11fa494 --- /dev/null +++ b/663/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/663/patient_pathological_data.json b/663/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..136bc4c925a569f840690dc8a532859406988df0 --- /dev/null +++ b/663/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "663", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/663/surgery_description.txt b/663/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..b3462b20d956f2cd501288ae93fbc2eabffd9d22 --- /dev/null +++ b/663/surgery_description.txt @@ -0,0 +1 @@ +Endoral laser resection and Panendoscopy diff --git a/663/surgery_report.txt b/663/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..282c55283ede1197ab313c1b1f38981ff4f27321 --- /dev/null +++ b/663/surgery_report.txt @@ -0,0 +1 @@ +First consultation with the anesthetist. Then advance the 0° telescope through the glottic plane into the trachea. This is very difficult due to the exophytic tumor. Finally, however, the trachea and the bronchial system can be inspected up to the exit of the segmental bronchi. The mucosal conditions here are unremarkable. Intubation of the patient by the anesthetist. Inspection of the subglottis, glottis and supraglottis. Inconspicuous mucosal conditions on all sides. No abnormalities in the area of the right hypopharyngeal and oropharyngeal swallowing tract. No evidence of tumor manifestation in the postcricoid region either. Now inspection of the left swallowing duct. An exophytic tumor can be seen here, which extends into the piriform sinus at the lower pole of the tonsil without reaching the tip of the piriform sinus. Medially, the base of the tongue is reached, but is obviously not clinically infiltrated. Now advance the esophagoscope into the stomach. No evidence of malignant mucosal changes in the area of the esophagus. Now inspection of the oral cavity. Inconspicuous mucosal conditions. Pulling up the soft palate. No pathological changes here either. Now adjustment of the oropharynx and hypopharynx using the Lawson retractor. This shows the described space requirement, which is very difficult to adjust due to difficult mouth opening. Once the ............................... has been satisfactorily adjusted, laser resection can begin. This involves cutting around the tumour in the area of the lower tonsil pole and gradually mobilizing it. Due to the size of the tumor, it is not possible to remove it in its entirety in one piece; the tumor must be divided. In this case, it is also necessary to move the barring device and insert another barring device (spreading laryngoscope). This allows the tumor to be resected step by step, with the tumor resection extending in the area of the lateral pharyngeal wall towards the base of the tongue and reaching just above the piriform sinus on the left side. Removal of several marginal samples. These marginal samples are found to be tumor-free in the frozen section. Careful hemostasis and completion of the procedure. Further procedure depending on the histology. Final discussion with the anesthesiologist, in the sense of a consultation. The patient is transferred to the recovery ward. \ No newline at end of file diff --git a/664/InvasionFront_CD3_block1_x1_y12_patient664_0.json b/664/InvasionFront_CD3_block1_x1_y12_patient664_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7a56fed94bc7ee1dd556a586404f068bb249b614 --- /dev/null +++ b/664/InvasionFront_CD3_block1_x1_y12_patient664_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3573.1, + "Centroid Y µm": 31708.2, + "Num Detections": 23031, + "Num Negative": 19549, + "Num Positive": 3482, + "Positive %": 15.12, + "Num Positive per mm^2": 1378.2 + } +} \ No newline at end of file diff --git a/664/InvasionFront_CD3_block1_x2_y12_patient664_1.json b/664/InvasionFront_CD3_block1_x2_y12_patient664_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f3309485058913953302141a5b0bd7a21901098 --- /dev/null +++ b/664/InvasionFront_CD3_block1_x2_y12_patient664_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5971.8, + "Centroid Y µm": 31733.2, + "Num Detections": 25154, + "Num Negative": 19914, + "Num Positive": 5240, + "Positive %": 20.83, + "Num Positive per mm^2": 2015.5 + } +} \ No newline at end of file diff --git a/664/InvasionFront_CD8_block1_x1_y12_patient664_0.json b/664/InvasionFront_CD8_block1_x1_y12_patient664_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b67d66fcf2474c257ed485caa15d5aae7b710a4 --- /dev/null +++ b/664/InvasionFront_CD8_block1_x1_y12_patient664_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 30184.0, + "Num Detections": 24110, + "Num Negative": 20145, + "Num Positive": 3965, + "Positive %": 16.45, + "Num Positive per mm^2": 1544.6 + } +} \ No newline at end of file diff --git a/664/InvasionFront_CD8_block1_x2_y12_patient664_1.json b/664/InvasionFront_CD8_block1_x2_y12_patient664_1.json new file mode 100644 index 0000000000000000000000000000000000000000..caa6b9394f82fc5119339738dcd001b34bb19fa1 --- /dev/null +++ b/664/InvasionFront_CD8_block1_x2_y12_patient664_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 30159.0, + "Num Detections": 26889, + "Num Negative": 21998, + "Num Positive": 4891, + "Positive %": 18.19, + "Num Positive per mm^2": 1874.1 + } +} \ No newline at end of file diff --git a/664/TumorCenter_CD8_block1_x1_y12_patient664_0.json b/664/TumorCenter_CD8_block1_x1_y12_patient664_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04b8dc108440e6eb24dc773b3366690db1031cdf --- /dev/null +++ b/664/TumorCenter_CD8_block1_x1_y12_patient664_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 39279.2, + "Num Detections": 28211, + "Num Negative": 22485, + "Num Positive": 5726, + "Positive %": 20.3, + "Num Positive per mm^2": 2122.4 + } +} \ No newline at end of file diff --git a/664/TumorCenter_CD8_block1_x2_y12_patient664_1.json b/664/TumorCenter_CD8_block1_x2_y12_patient664_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b29ad96a7614b2a53f72c968724fddb54eee4190 --- /dev/null +++ b/664/TumorCenter_CD8_block1_x2_y12_patient664_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9395.0, + "Centroid Y µm": 39079.3, + "Num Detections": 25725, + "Num Negative": 23098, + "Num Positive": 2627, + "Positive %": 10.21, + "Num Positive per mm^2": 1036.5 + } +} \ No newline at end of file diff --git a/664/history_text.txt b/664/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c9f46fbfea3f93626a2a79610e652f0543e44c4f --- /dev/null +++ b/664/history_text.txt @@ -0,0 +1 @@ +Post-parotid carcinoma on the right in the 90s. In the course of the disease, a large progressive mass on the left cervical side. There is now an indication for extirpation of the left cervical lymph node conglomerate and panendoscopy. Preoperative imaging revealed a centrally necrotic, disintegrating left cervical lymph node conglomerate and a faint accumulation of contrast medium in the area of the left tonsil. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/664/icd_codes.txt b/664/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eea8583c2896d83437fc46838a3cfc7af2ea242f --- /dev/null +++ b/664/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Gaumenbogentonsillen[C09.1 L] \ No newline at end of file diff --git a/664/ops_codes.txt b/664/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..61cfb2fc5a70a4add47551ee9685c55e70243dfd --- /dev/null +++ b/664/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/664/patient_clinical_data.json b/664/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d3b314c80f6a0e68c6b2243f1afa828618969402 --- /dev/null +++ b/664/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 72, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/664/patient_pathological_data.json b/664/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4b31473d33908de7c7123b833c24de8fb77fd675 --- /dev/null +++ b/664/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "664", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 5, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/664/surgery_description.txt b/664/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..eb6c887b01905d455b24889fb401b48f1d9164c0 --- /dev/null +++ b/664/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Bilateral neck dissection, Panendoscopy diff --git a/664/surgery_report.txt b/664/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f60eb68dcb2e3d39f03f8c6ff1518d5642850044 --- /dev/null +++ b/664/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. Start of lymph node extirpation. Palpatory identification of the conglomerate of nodes. Infiltration anesthesia is then performed after skin spray disinfection. Ablation of the surgical site. Sterile draping. Marking of the mandibular arch and the ascending mandibular branch. Mark the planned incision from the infralobular, laterocaudal, curved bayonet shape. Cut sharply through the cutis and subcutis. Dissection of the platysma. Dissection of the sternocleidomastoid muscle. Exposure of the lymph node conglomerate. This lies lateral to the cervical vascular sheath. Cranially, the mass is directly adjacent to the accessorius nerve. Medially, the conglomerate extends to just before the hypoglossal nerve. Exposure, displacement and, at the end of the operation, re-embedding of the accessory nerve and hypoglossal nerve in the sense of a neurolysis. Exposure of the internal jugular vein. Successive dissection of the conglomerate. Sending it for frozen section diagnostics. During the frozen section diagnosis by telephone, a squamous cell carcinoma is suspected. Therefore complete the neck dissection. Exposure of the posterior digastric venter muscle as the cranial border. Insertion of the retractors. Exposure of the internal jugular vein including the venous angle. Exposure of the common carotid artery and the bifurcation. Successive development of the lateral neck preparation with careful protection of the accessorius nerve and the plexus branches. With the exception of a small nodule in level III, there are no other suspicious nodules. Turning to the medial neck preparation. Here, too, no further suspicious nodes were found. As the intraparenchymal nodules located in the caudal parotid pole have already appeared sonographically constant for years, a further procedure is deliberately omitted here. Neuro-monitoring is used at the end of the operation to check the integrity of the accessory nerve and the hypoglossal nerve. The oral branch did not have to be visualized intraoperatively. Hemostasis using bipolar coagulation. Wound irrigation with H2O2 and Ringer's solution. Insertion of a 10-gauge redon drain. Subcutaneous suture with Vicryl 4-0 and skin suture with Ethilon 5-0. Application of a pressure bandage. Transition to panendoscopy. First positioning of the patient in head reclination. Insertion of the mouth guard. Enter with the size C small bore tube. First inspect the endolarynx. This appears unremarkable. Inspection of the piriform sinus. This is lined on both sides by smooth mucosa on all sides and can be freely unfolded up to the tip. The same applies to the postcricoid region and the esophageal entrance. A small retention cyst can be seen in the area of the vallecula on the left side. This is marsupialized. However, there is no evidence of malignancy here. This also applies to the base of the tongue and the corpus of the tongue. There is also no evidence of a tumor in the area of the oral cavity or the oral vestibule. Proceed to esophagogastroscopy. Insertion of the flexible endoscope under visualization and constant air insufflation into the stomach. A typical gastric mucosal relief can be seen on all sides. Inversion and inspection of the gastroesophageal junction. This also appears unremarkable. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. Here too, there is no evidence of malignancy. Removal of the flexible endoscope. First insertion of the McIvor oral spatula. Inspection of the left tonsil. A primarily suspicious area can be seen in the depth of the crypts just below the upper tonsil pole. If it is suspected that this could be the primary, the tumor tonsillectomy is now performed with the necessary safety margin. For this purpose, a parauvular incision and resection of the left tonsil including parts of the anterior and posterior palatal arch is performed first. Lateral dissection is performed up to the parapharyngeal fatty tissue. Exposure of the lower tonsil pole. The suture is marked before the tonsil is removed. Sending the tonsil for frozen section diagnostics. In the meantime, hemostasis is performed. During the frozen section diagnosis by telephone, an R0 resected tonsil carcinoma is found in the area of the left tonsil. A mucosoplasty is performed. With a dry wound bed, the operation is now completed without complications. Final consultation with the anesthesiologist. \ No newline at end of file diff --git a/665/InvasionFront_CD3_block12_x3_y6_patient665_0.json b/665/InvasionFront_CD3_block12_x3_y6_patient665_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e923a75f9c9f3d8a3873306740e1507337dba802 --- /dev/null +++ b/665/InvasionFront_CD3_block12_x3_y6_patient665_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11369.0, + "Centroid Y µm": 19789.5, + "Num Detections": 20980, + "Num Negative": 20902, + "Num Positive": 78, + "Positive %": 0.3718, + "Num Positive per mm^2": 32.0 + } +} \ No newline at end of file diff --git a/665/InvasionFront_CD3_block12_x4_y6_patient665_1.json b/665/InvasionFront_CD3_block12_x4_y6_patient665_1.json new file mode 100644 index 0000000000000000000000000000000000000000..36ea48ba585bf6d365ee15881781c33dc5ba0d1e --- /dev/null +++ b/665/InvasionFront_CD3_block12_x4_y6_patient665_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 19889.5, + "Num Detections": 20839, + "Num Negative": 20744, + "Num Positive": 95, + "Positive %": 0.4559, + "Num Positive per mm^2": 39.4 + } +} \ No newline at end of file diff --git a/665/InvasionFront_CD8_block12_x3_y6_patient665_0.json b/665/InvasionFront_CD8_block12_x3_y6_patient665_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7029ee805efe26832e755f74193a729820e2e36f --- /dev/null +++ b/665/InvasionFront_CD8_block12_x3_y6_patient665_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12093.6, + "Centroid Y µm": 18890.0, + "Num Detections": 22368, + "Num Negative": 21969, + "Num Positive": 399, + "Positive %": 1.784, + "Num Positive per mm^2": 165.52 + } +} \ No newline at end of file diff --git a/665/InvasionFront_CD8_block12_x4_y6_patient665_1.json b/665/InvasionFront_CD8_block12_x4_y6_patient665_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6a538d222f32b821885983b6b40d0ac132935c2 --- /dev/null +++ b/665/InvasionFront_CD8_block12_x4_y6_patient665_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 18690.1, + "Num Detections": 20672, + "Num Negative": 20511, + "Num Positive": 161, + "Positive %": 0.7788, + "Num Positive per mm^2": 70.39 + } +} \ No newline at end of file diff --git a/665/TumorCenter_CD3_block12_x3_y6_patient665_0.json b/665/TumorCenter_CD3_block12_x3_y6_patient665_0.json new file mode 100644 index 0000000000000000000000000000000000000000..400b0c67085fc206d9328ef4f55a6b31b48e85dd --- /dev/null +++ b/665/TumorCenter_CD3_block12_x3_y6_patient665_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 14967.1, + "Num Detections": 22606, + "Num Negative": 21936, + "Num Positive": 670, + "Positive %": 2.964, + "Num Positive per mm^2": 282.51 + } +} \ No newline at end of file diff --git a/665/TumorCenter_CD3_block12_x4_y6_patient665_1.json b/665/TumorCenter_CD3_block12_x4_y6_patient665_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0ab999d65a461fb37c6fed9b5e0c7297f9eae1f8 --- /dev/null +++ b/665/TumorCenter_CD3_block12_x4_y6_patient665_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 14967.1, + "Num Detections": 23927, + "Num Negative": 23823, + "Num Positive": 104, + "Positive %": 0.4347, + "Num Positive per mm^2": 42.0 + } +} \ No newline at end of file diff --git a/665/TumorCenter_CD8_block12_x3_y6_patient665_0.json b/665/TumorCenter_CD8_block12_x3_y6_patient665_0.json new file mode 100644 index 0000000000000000000000000000000000000000..92a1dabf258933a40ed40fe8052924e4c44045dc --- /dev/null +++ b/665/TumorCenter_CD8_block12_x3_y6_patient665_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14067.6, + "Centroid Y µm": 24337.1, + "Num Detections": 20451, + "Num Negative": 20189, + "Num Positive": 262, + "Positive %": 1.281, + "Num Positive per mm^2": 111.13 + } +} \ No newline at end of file diff --git a/665/TumorCenter_CD8_block12_x4_y6_patient665_1.json b/665/TumorCenter_CD8_block12_x4_y6_patient665_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6ea427682f92340aa25c3f1f03bcb2b5ecc288d8 --- /dev/null +++ b/665/TumorCenter_CD8_block12_x4_y6_patient665_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16641.2, + "Centroid Y µm": 24537.0, + "Num Detections": 17595, + "Num Negative": 17263, + "Num Positive": 332, + "Positive %": 1.887, + "Num Positive per mm^2": 140.49 + } +} \ No newline at end of file diff --git a/665/history_text.txt b/665/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..62a93293d0900d3392df8a16bd93b4e0ed3983c3 --- /dev/null +++ b/665/history_text.txt @@ -0,0 +1 @@ +The patient has an endoscopic carcinoma of the right-sided base of the tongue, which has affected the anterior surface of the epiglottis. The diameter is about 2.5 cm. Ultrasonographically, the neck lymph node status is cN2b, but this must be expanded to cN2c as part of the neck dissection. \ No newline at end of file diff --git a/665/icd_codes.txt b/665/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/665/ops_codes.txt b/665/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2bcc0b47985626a75f9828d486a66daeb3fa718f --- /dev/null +++ b/665/ops_codes.txt @@ -0,0 +1 @@ +Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Destruktion: Laserkoagulation[5-250.31 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Exzision und Destruktion einer Zungengrundtonsille: Transoral[5-284.0 ] Temporäre Tracheostomie: Tracheotomie[5-311.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/665/patient_clinical_data.json b/665/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6c826695aa3696f18476b84cc874b3cf68a0f5cb --- /dev/null +++ b/665/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2009, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/665/patient_pathological_data.json b/665/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..83b30a14c29d95145fd06198a304341c77179d63 --- /dev/null +++ b/665/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "665", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 61, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/665/surgery_description.txt b/665/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..76516399d4f5bb37873aa8ed579838cfdd162b10 --- /dev/null +++ b/665/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Bilateral neck dissection, Tracheotomy, PEG placement diff --git a/665/surgery_report.txt b/665/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..285271fb449d5643dec361c489c051ca9af525d6 --- /dev/null +++ b/665/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia at the beginning of the operation. Followed by flexible esophagoscopy and, after positive diaphanoscopy, PEG insertion in the usual manner. No evidence of tumor or stenosis of the esophagus on retraction. Now enter with the spread laryngoscope and expose the tumor in the area of the right base of the tongue. Then use of the operating microscope. An exulcerated tumor of the anterior surface of the epiglottis can be seen, which grows into the base of the vallecula and then upwards into the base of the tongue. Laterally, the pharyngeal wall is not infiltrated. The aryepiglottic fold caudally is also free, so that it is a localized tongue base process. First cut through the tumor to expose the deep infiltration. This is performed with the Co2 laser in cw mode at 10 W. Now cut around the tumor on the left side towards the middle of the tongue base strictly in the tongue base. Then cut around the part of the tongue base tumor on the right side up to the pharyngeal wall and remove this piece. ...copically all musculature on all sides. The epiglottis is now cut in the middle with the laser beam and the epiglottis tumor section is removed. The epiglottis is generously cut away laterally and resected up to the edge of the aryepiglottic fold. Now hemostasis with supratupers and extensive monopolar coagulation. Subsequently, marginal samples are taken from the area of the aryepiglottic fold, from the middle of the tongue base, deep and superficial, from the left and right sides of the tongue base. Samples are sent for frozen section and are all found to be tumor-free during the operation. Later during the operation, during the neck dissection, there is more severe bleeding from the mouth, so that another endoscopy is required and an arterial vessel located at the lateral base of the tongue can be bipolarly coagulated. ..... extends as far as the hyoid bone. Now transfer to neck dissection on both sides. Start with the neck dissection on the right, which has clinical cN2b status. Curved skin incision in the area of the sternocleidomastoid after instillation of 10 ml xylocaine with adrenaline. Cut through the skin tissue and subcutaneous tissue and expose the anterior edge of the muscle. Subsequent exposure of the nervus accessorius and the cervical vascular sheath. It can be seen that an approx. 3 x 3 cm large mass is located in the jugulofacial angle and extends to the submandibular gland. However, this mass can be bluntly dissected away from the gland in a nice shifting layer. First remove the mass. Then completely expose the cervical vascular sheath in the sense of the common carotid artery, internal jugular vein and vagus nerve. The posterior neck specimen is then removed, preserving all the structures mentioned, and deposited at the caudal end after coagulation. The cervical plexus branches can be preserved. Complete the anterior neck dissection after exposing the hypoglossal nerve, taking the capsule of the submandibular gland with it. Now hemostasis. Followed by hydrogen and ring irrigation, insertion of a Redon drain and 2-layer wound closure. Transfer to the opposite side and here, after instillation of 10 ml xylocaine with added adrenaline, another skin incision on the sternocleidomastoid. Expose the anterior border of the sternocleidomastoid muscle and, as on the opposite side, the accessorius nerve, the cervical vascular sheath in the sense of the common carotid artery, internal jugular vein and vagus nerve. First, the posterior neck preparation is then removed from under the accessorius nerve and all the structures mentioned, including the cervical plexus, are removed without damaging them. A lymph node is then also removed in the jugulofacial angle, as on the opposite side. However, this is significantly smaller here and could also be reactive. Furthermore, removal of the capsule of the submandibular gland and completion of the anterior neck. Exposure of the hypoglossal nerve. Now hemostasis, hydrogen and ring irrigation and insertion of a Redon drain. Followed by another demonstration of findings on and 2-layer wound closure. Now proceed to tracheotomy. Modified Kocher collar incision. Cut through the subcutaneous tissue and the prelaryngeal muscle tissue and dissect the cricoid cartilage. Exposure of the thyroid isthmus. Undermining of the same and removal of the same after repositioning. Entering the trachea between the 1st and 2nd tracheal clasp and, after creating a small Björk flap, suturing or epithelizing the tracheostoma in the usual manner. An 8 mm cannula is inserted. Finally, another enoral inspection and removal of the previously inserted swabs. Re-coagulation in a few places. If the wound is dry, the patient receives 250 mg SDH and has received intraoperative antibiotics with Unacid 3 g, which should be continued postoperatively with 3x 1.5 g. \ No newline at end of file diff --git a/666/InvasionFront_CD3_block13_x1_y10_patient666_0.json b/666/InvasionFront_CD3_block13_x1_y10_patient666_0.json new file mode 100644 index 0000000000000000000000000000000000000000..427a2a4afb3370dc93279d95c89f9847ee59e41f --- /dev/null +++ b/666/InvasionFront_CD3_block13_x1_y10_patient666_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 24037.3, + "Num Detections": 18121, + "Num Negative": 16413, + "Num Positive": 1708, + "Positive %": 9.426, + "Num Positive per mm^2": 705.32 + } +} \ No newline at end of file diff --git a/666/InvasionFront_CD3_block13_x2_y10_patient666_1.json b/666/InvasionFront_CD3_block13_x2_y10_patient666_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3722dc093a9f74e4109102bc106df056982a3ca4 --- /dev/null +++ b/666/InvasionFront_CD3_block13_x2_y10_patient666_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 24062.3, + "Num Detections": 17840, + "Num Negative": 14167, + "Num Positive": 3673, + "Positive %": 20.59, + "Num Positive per mm^2": 1539.0 + } +} \ No newline at end of file diff --git a/666/InvasionFront_CD8_block13_x1_y10_patient666_0.json b/666/InvasionFront_CD8_block13_x1_y10_patient666_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ab6d25de95fa7a6d075a3b592d974dd72b9b5096 --- /dev/null +++ b/666/InvasionFront_CD8_block13_x1_y10_patient666_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4222.8, + "Centroid Y µm": 25586.5, + "Num Detections": 21859, + "Num Negative": 18041, + "Num Positive": 3818, + "Positive %": 17.47, + "Num Positive per mm^2": 1495.0 + } +} \ No newline at end of file diff --git a/666/InvasionFront_CD8_block13_x2_y10_patient666_1.json b/666/InvasionFront_CD8_block13_x2_y10_patient666_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69c6d7e997a993db489ef8eca9858c0840c2339e --- /dev/null +++ b/666/InvasionFront_CD8_block13_x2_y10_patient666_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 25536.5, + "Num Detections": 13498, + "Num Negative": 9980, + "Num Positive": 3518, + "Positive %": 26.06, + "Num Positive per mm^2": 2140.5 + } +} \ No newline at end of file diff --git a/666/TumorCenter_CD3_block13_x1_y10_patient666_0.json b/666/TumorCenter_CD3_block13_x1_y10_patient666_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4869ed7832267f9fb9214bf08e3051c2baa2ec02 --- /dev/null +++ b/666/TumorCenter_CD3_block13_x1_y10_patient666_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 30783.7, + "Num Detections": 21670, + "Num Negative": 16046, + "Num Positive": 5624, + "Positive %": 25.95, + "Num Positive per mm^2": 2116.1 + } +} \ No newline at end of file diff --git a/666/TumorCenter_CD3_block13_x2_y10_patient666_1.json b/666/TumorCenter_CD3_block13_x2_y10_patient666_1.json new file mode 100644 index 0000000000000000000000000000000000000000..20a523b79c08c07bc02878c438923cb18c58e150 --- /dev/null +++ b/666/TumorCenter_CD3_block13_x2_y10_patient666_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 31033.6, + "Num Detections": 16212, + "Num Negative": 13156, + "Num Positive": 3056, + "Positive %": 18.85, + "Num Positive per mm^2": 1332.5 + } +} \ No newline at end of file diff --git a/666/TumorCenter_CD8_block13_x1_y10_patient666_0.json b/666/TumorCenter_CD8_block13_x1_y10_patient666_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42a111ea640d63334b4a022abcd0114b447b0fe4 --- /dev/null +++ b/666/TumorCenter_CD8_block13_x1_y10_patient666_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 25636.4, + "Num Detections": 21427, + "Num Negative": 17040, + "Num Positive": 4387, + "Positive %": 20.47, + "Num Positive per mm^2": 1708.5 + } +} \ No newline at end of file diff --git a/666/TumorCenter_CD8_block13_x2_y10_patient666_1.json b/666/TumorCenter_CD8_block13_x2_y10_patient666_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a2e956b42ace1609135e96e88ea1d81634586603 --- /dev/null +++ b/666/TumorCenter_CD8_block13_x2_y10_patient666_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8345.6, + "Centroid Y µm": 25361.6, + "Num Detections": 15105, + "Num Negative": 13190, + "Num Positive": 1915, + "Positive %": 12.68, + "Num Positive per mm^2": 852.57 + } +} \ No newline at end of file diff --git a/666/history_text.txt b/666/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1710b0f5e0b00daf9a5967f6e5fbd5cfbdcbff6b --- /dev/null +++ b/666/history_text.txt @@ -0,0 +1 @@ +Patient with cT4 carcinoma of the edge of the tongue/bottom of the mouth on the left. Histologically confirmed squamous cell carcinoma. CT diagnosis performed and flap coverage indicated. \ No newline at end of file diff --git a/666/icd_codes.txt b/666/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed44aeeed6326cf03a8a4795fea55acfc3032efd --- /dev/null +++ b/666/icd_codes.txt @@ -0,0 +1 @@ +Plattenepithelkarzinom Zungenrand[C02.1 L] Bösartige Neubildung sekundär und onA Lymphknoten mehrere Regionen[C77.8 B] \ No newline at end of file diff --git a/666/ops_codes.txt b/666/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d84c58ba011127c547ab27247653c9504f4811d --- /dev/null +++ b/666/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroduodenoskopie bei normalem Situs[1-632.0 ] Partielle Glossektomie durch Pharyngotomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.22 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Temporäre Tracheotomie[5-311.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 L] Entnahme freier Radialis-Lappen[5-858.23 L] Mikrochirurgische Technik (Zusatzkode)[5-984 ] \ No newline at end of file diff --git a/666/patient_clinical_data.json b/666/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6801c4e27bb8837dd435ca5785c70ba65fdb39cf --- /dev/null +++ b/666/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/666/patient_pathological_data.json b/666/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e605617b7769c1e51e7bc9ea7ffff55579c4f416 --- /dev/null +++ b/666/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "666", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/666/surgery_description.txt b/666/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8ffa1915914ac757c8d318cf75012261c5d7ed80 --- /dev/null +++ b/666/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Bilateral neck dissection, Defect coverage, Tracheostomy creation diff --git a/666/surgery_report.txt b/666/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c6ce889d1f3b54a0241e65e34cd0a9f3440667ef --- /dev/null +++ b/666/surgery_report.txt @@ -0,0 +1 @@ +First, after preparation for anesthesia, pharyngoscopy and laryngoscopy or inspection of the oral cavity: The tumor is seen on the left edge of the tongue, extending to the front and side of the floor of the mouth, but not quite reaching the alveolar ridge. Subsequent transoral tumor resection: The tumor is macroscopically incised on all sides with a safety margin of 1.5 cm in the sense of a hemiglossectomy, whereby the base of the tongue is only partially resected. Resection extends forward to the floor of the mouth. Removal of the soft tissue from the bone. Removal of the external tongue muscles and sublingual gland as well as resection of the lingual nerve. Resection extends posteriorly to the posterior floor of the mouth including the glossoalveolar groove and parts of the base of the tongue. The specimen is removed and marked with a suture. A marginal sample is taken from the mucosa at the front and sides of the alveolar ridge as well as a marginal sample of basal tissue. In the frozen section, both tumor and margin samples are free of carcinoma. Thus R0 resection. Careful hemostasis. Now repositioning for continuation of the operation. First tracheostoma creation (): A horizontal incision of about 4 cm 2 QF above the jugulum is made, sharply cutting through the skin, subcutaneous tissue as well as the platysma. The prelaryngeal musculature or infrahyoid musculature is exposed, entered in the midline and the thyroid gland is exposed. Dissection of the trachea between the cricoid cartilage and isthmus. The isthmus is cut and stitched on both sides. No major bleeding. Between the 2nd and 3rd tracheal cartilage clasp, the trachea is entered and a visual tracheotomy is created. The patient is intubated with an 8-gauge cannula. Completion of the procedure without complications. Neck dissection on both sides, neck dissection on the left first: Curved skin incision. Subsequent exposure of the digastric muscle, omohyoid muscle, sternocleidomastoid muscle and infrahyoid muscles. Expose the cervical vascular sheath, internal jugular vein, internal, external and common carotid artery. Expose vagus nerve, accessorius nerve, hypoglossal nerve. All structures are preserved, as is the cervical artery. Level I b to 5 are removed, including removal of the submandibular gland with exposure and protection of the marginal mandibular nerve. This results in the removal of levels I b to V. Subsequent careful hemostasis. No evidence of bleeding or lymph flow on final assessment. Subsequent neck dissection on the right side: In principle, this is performed in the same way as on the left side. Exposure of the aforementioned structures and preservation of these. Removal of levels I b to V, but with preservation of the submandibular gland on this side. Subsequent skin closure here in layers with insertion of a Redon drainage. Then elevation of the radial lobe (, PJ). Palpatory identification of the distal radial artery. Marking of the flap borders (10x8cm) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation using silk ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Then removal of split skin with the dermatome set to 8000 turns and 0.8 mm layer. A split-thickness skin graft measuring 10 x 8 cm is harvested from the right thigh. After harvesting the flap from the left forearm, the proximal incision is closed in two layers with Vicryl 3-0, Ethilon 5-0. The lifting defect of the radialis flap is adapted with 2-0 Vicryl and then the split skin is sutured in place. Split skin is stitched and applied to the dressing in the typical manner. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Then PEG (/): Entering with the gastroesophagoscope and with air insufflation, pre-scintillation into the stomach. This shows a positive diaphanoscopy, therefore indication for PEG insertion. The needle is now inserted as far as it will go, but the anterior stomach wall is not penetrated. This is carried out at three different, promising sites, here also no penetration of the anterior stomach wall. The PEG was therefore discontinued and a nasogastric tube was inserted in the typical manner. The radialis flap is inserted into the defect in the mouth area: To do this, first widen the tunnel from the floor of the mouth into the soft tissues of the neck. 2 transverse fingers can be pushed through easily. Then pass the pedicle through after inserting the flap into the defect. Successive suturing of the flap into the defect with 3.0 Vicryl single button sutures, this is achieved without tension and completely. Then anastomosis of the flap pedicle. For this purpose, the superior thyroid artery is selected and conditioned. After conditioning the radial artery, suture with 8.0 Ethilon single-button sutures. After opening the clamps, good arterial flow and good venous return. Subsequent conditioning of 2 outlets from the area of the facial vein, this one close to the internal jugular vein. After conditioning of 2 venous outlets from the flap area and 2 outlets from the facial vein area, anastomosis is performed with 2.5 mm couplers. Good venous return in each case after opening the clamps, positive smear phenomenon. Overall flap also well perfused enorally. Vascular pedicle is now placed and partly fixed with sutures to prevent kinking. Subsequent irrigation of the wound area. Careful hemostasis. Wound closure in layers with insertion of a Redon drain and a flap. The procedure is then completed without complications. Patient is transferred to the intensive care unit for postoperative monitoring. Please monitor flap clinically for 5 days according to schedule, using Doppler monitoring if necessary. Feeding via the inserted PEG tube for approx. 10 days, then if necessary, nutritional support. Overall cT4 cN2c status. Wait for the final histology and presentation at the interdisciplinary tumor conference to plan further adjuvant therapy. \ No newline at end of file diff --git a/667/InvasionFront_CD3_block15_x5_y10_patient667_0.json b/667/InvasionFront_CD3_block15_x5_y10_patient667_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a0f057a8b18f326a2ea14d07803b42f4ee674607 --- /dev/null +++ b/667/InvasionFront_CD3_block15_x5_y10_patient667_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 34756.6, + "Num Detections": 20123, + "Num Negative": 18748, + "Num Positive": 1375, + "Positive %": 6.833, + "Num Positive per mm^2": 625.7 + } +} \ No newline at end of file diff --git a/667/InvasionFront_CD3_block15_x6_y10_patient667_1.json b/667/InvasionFront_CD3_block15_x6_y10_patient667_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3fdace0145eda4d6187b00254c7015d933cb0692 --- /dev/null +++ b/667/InvasionFront_CD3_block15_x6_y10_patient667_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21588.6, + "Centroid Y µm": 34731.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/667/InvasionFront_CD8_block15_x5_y10_patient667_0.json b/667/InvasionFront_CD8_block15_x5_y10_patient667_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e226840e68cbb259528e374153b04f7822b1b4dc --- /dev/null +++ b/667/InvasionFront_CD8_block15_x5_y10_patient667_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16564.9, + "Centroid Y µm": 24411.7, + "Num Detections": 14584, + "Num Negative": 13849, + "Num Positive": 735, + "Positive %": 5.04, + "Num Positive per mm^2": 383.11 + } +} \ No newline at end of file diff --git a/667/InvasionFront_CD8_block15_x6_y10_patient667_1.json b/667/InvasionFront_CD8_block15_x6_y10_patient667_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e50070a0f17d1ce85941998cdba4416f61775879 --- /dev/null +++ b/667/InvasionFront_CD8_block15_x6_y10_patient667_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19032.2, + "Centroid Y µm": 24399.5, + "Num Detections": 19837, + "Num Negative": 18487, + "Num Positive": 1350, + "Positive %": 6.805, + "Num Positive per mm^2": 567.39 + } +} \ No newline at end of file diff --git a/667/TumorCenter_CD3_block15_x5_y10_patient667_0.json b/667/TumorCenter_CD3_block15_x5_y10_patient667_0.json new file mode 100644 index 0000000000000000000000000000000000000000..821751df5211b374e3c1b077d3302bd1bce75284 --- /dev/null +++ b/667/TumorCenter_CD3_block15_x5_y10_patient667_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 28684.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/667/TumorCenter_CD3_block15_x6_y10_patient667_1.json b/667/TumorCenter_CD3_block15_x6_y10_patient667_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7921fb7812dcb0e6100f879e99798206010f9c05 --- /dev/null +++ b/667/TumorCenter_CD3_block15_x6_y10_patient667_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18665.1, + "Centroid Y µm": 28559.9, + "Num Detections": 19905, + "Num Negative": 17399, + "Num Positive": 2506, + "Positive %": 12.59, + "Num Positive per mm^2": 1124.6 + } +} \ No newline at end of file diff --git a/667/TumorCenter_CD8_block15_x5_y10_patient667_0.json b/667/TumorCenter_CD8_block15_x5_y10_patient667_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3d7928c0eac765d0cfac19c825926a871c2a0af0 --- /dev/null +++ b/667/TumorCenter_CD8_block15_x5_y10_patient667_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 25036.7, + "Num Detections": 18481, + "Num Negative": 15963, + "Num Positive": 2518, + "Positive %": 13.62, + "Num Positive per mm^2": 1156.1 + } +} \ No newline at end of file diff --git a/667/TumorCenter_CD8_block15_x6_y10_patient667_1.json b/667/TumorCenter_CD8_block15_x6_y10_patient667_1.json new file mode 100644 index 0000000000000000000000000000000000000000..268d30767c82df25bcef21c8253250a0264adab0 --- /dev/null +++ b/667/TumorCenter_CD8_block15_x6_y10_patient667_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21238.8, + "Centroid Y µm": 24986.8, + "Num Detections": 20154, + "Num Negative": 18088, + "Num Positive": 2066, + "Positive %": 10.25, + "Num Positive per mm^2": 946.02 + } +} \ No newline at end of file diff --git a/667/history_text.txt b/667/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/667/icd_codes.txt b/667/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3a2fa7820265ba8e3b4031b893a2de884b53c3f2 --- /dev/null +++ b/667/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 R] Parotiszystadenolymphom[D11.0 R] \ No newline at end of file diff --git a/667/ops_codes.txt b/667/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f2acaa069f7f77153a8199c577ef9187b44b276 --- /dev/null +++ b/667/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion der Zunge mit Rekonstruktion mit gestieltem Fernlappen[5-251.03 ] Mundbodenteilresektion[5-273.6 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 R] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] Totale Parotidektomie mit Fazialismonitoring[5-262.11 R] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] \ No newline at end of file diff --git a/667/patient_clinical_data.json b/667/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..101a92dee0f72b434051c781158695b45a8adf0e --- /dev/null +++ b/667/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 72, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/667/patient_pathological_data.json b/667/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f50a949b475c40334caf2612cd5309ff64c45c5 --- /dev/null +++ b/667/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "667", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/667/surgery_description.txt b/667/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d4051b58091d5cf56ba64900e04f4171d5cb3f6 --- /dev/null +++ b/667/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Neck dissection, PEG placement diff --git a/667/surgery_report.txt b/667/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..30ec17e276b894a0ae3e556998da7fd2418edbdd --- /dev/null +++ b/667/surgery_report.txt @@ -0,0 +1 @@ +Induction and intubation by the anesthetist. Inspection of the oral cavity. Insertion of the spandex and looping of the tongue. Mobilization of the tongue. There is an exophytic mass on the edge of the tongue on the right side with transition to the base of the tongue and the floor of the mouth with extensions into the anterior floor of the mouth. Mark the edges of the incision with the monopolar needle with a safety margin of 0.5 to 1 cm. The mass is then dissected out all around with scissors and bipolar forceps. It is sent to histology marked with a thread. The pathologist can only detect a very narrow resection margin in two places: the lateral floor of the mouth and the basal floor of the mouth. Both are resected again and another marginal sample is sent for frozen section, so that the tumor is ultimately resected with an R0 situation. The result is a fairly large defect that affects the edge of the tongue and also the floor of the mouth. An extracapsular dissection of an unclear mass on the right parotid gland was then performed. This is also sent for a frozen section. Here the pathologist can identify a Warthin's tumor. Neck dissection performed on the left side by . Here the platysma is shown. Dissection of the platysma. Dissection of the platysma. Exposure of the sternocleidomastoid muscle, the internal jugular vein, the accessorius nerve and the digastric muscle, the submandibular gland. Clearing of levels I to IV while sparing the plexus branches and the submandibular gland and hypoglossal nerve. Neck dissection on the right side. Exposure of the platysma. Dissection of the platysma. Exposure of the sternocleidomastoid muscle, the submandibular gland, the digastric muscle, the accessorius nerve, the internal jugular vein, vagus and external/internal carotid artery. Removal of the submandibular gland. Release of the neck preparations I to V while protecting the plexus branches. Blunt dissection towards the floor of the mouth and creation of an opening to the oral cavity. The opening is wide enough to allow 4 transverse fingers to pass through, so the digastric muscle is not cut. The defect is covered with a supraclavicular island flap. Before starting the operation, the transverse cervical artery was identified and marked using the hand-held Doppler. Skin incision over the acromion into the shoulder area. Cutting around the flap, 8 x 5 cm. Lift the flap, taking the fascia of the deltoid muscle with it. Dissection of the pedicle without exposing it, taking subcutaneous fatty tissue with it. Creation of a bridge to the neck. Pulling the pedicle and flap through the bridge and inserting the flap into the mouth area. Incision of the flap in the tongue and floor of the mouth area. Due to the Warthin's tumor in the parotid gland, which also shows other masses, a complete parotidectomy is performed after consultation with . For this purpose, a facial nerve monitor is placed. Visualization of the main trunk of the facial nerve. Exposure of the first major division. Then dissection along the branches and removal of the entire parotid gland tissue. Then removal of the glandular tissue below the main trunk and between the branches. Finally, insertion of Redon drains and two-layer wound closure. Finally, creation of a tracheostoma. For this, skin incision in the usual manner. Dissection down to the thyroid gland. Dissection of the thyroid gland. Exposure of the trachea. Creation of a visor tracheostomy. Creation of a mucocutaneous anastomosis and insertion of an 8-gauge tracheostomy tube. The patient goes to the intensive care unit. \ No newline at end of file diff --git a/668/InvasionFront_CD3_block1_x3_y6_patient668_0.json b/668/InvasionFront_CD3_block1_x3_y6_patient668_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0a6bbcb3a7e7e908e08cd2e8fa955c790945bbcf --- /dev/null +++ b/668/InvasionFront_CD3_block1_x3_y6_patient668_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11668.8, + "Centroid Y µm": 16841.1, + "Num Detections": 15250, + "Num Negative": 14830, + "Num Positive": 420, + "Positive %": 2.754, + "Num Positive per mm^2": 200.02 + } +} \ No newline at end of file diff --git a/668/InvasionFront_CD3_block1_x4_y6_patient668_1.json b/668/InvasionFront_CD3_block1_x4_y6_patient668_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb9f0cdeca771cb80f311511abb60ecf674165a2 --- /dev/null +++ b/668/InvasionFront_CD3_block1_x4_y6_patient668_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 16916.0, + "Num Detections": 23825, + "Num Negative": 22865, + "Num Positive": 960, + "Positive %": 4.029, + "Num Positive per mm^2": 418.67 + } +} \ No newline at end of file diff --git a/668/InvasionFront_CD8_block1_x3_y6_patient668_0.json b/668/InvasionFront_CD8_block1_x3_y6_patient668_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2c90f3b68584598d9e12f3cea633b6a3ce425b5d --- /dev/null +++ b/668/InvasionFront_CD8_block1_x3_y6_patient668_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 15391.9, + "Num Detections": 25813, + "Num Negative": 24844, + "Num Positive": 969, + "Positive %": 3.754, + "Num Positive per mm^2": 397.17 + } +} \ No newline at end of file diff --git a/668/InvasionFront_CD8_block1_x4_y6_patient668_1.json b/668/InvasionFront_CD8_block1_x4_y6_patient668_1.json new file mode 100644 index 0000000000000000000000000000000000000000..887c18cbef83725d6a5e833a7aaad790995c47ca --- /dev/null +++ b/668/InvasionFront_CD8_block1_x4_y6_patient668_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 15541.8, + "Num Detections": 24155, + "Num Negative": 23352, + "Num Positive": 803, + "Positive %": 3.324, + "Num Positive per mm^2": 340.32 + } +} \ No newline at end of file diff --git a/668/TumorCenter_CD3_block1_x3_y8_patient668_0.json b/668/TumorCenter_CD3_block1_x3_y8_patient668_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b29809ef905d722fe8c57984d2f9dc768506c2a5 --- /dev/null +++ b/668/TumorCenter_CD3_block1_x3_y8_patient668_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10955.9, + "Centroid Y µm": 19948.9, + "Num Detections": 8112, + "Num Negative": 8107, + "Num Positive": 5, + "Positive %": 0.0616, + "Num Positive per mm^2": 4.408 + } +} \ No newline at end of file diff --git a/668/TumorCenter_CD3_block1_x4_y8_patient668_1.json b/668/TumorCenter_CD3_block1_x4_y8_patient668_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b8f94ab29719e46ef80c23f30ccc751fa18ab0f --- /dev/null +++ b/668/TumorCenter_CD3_block1_x4_y8_patient668_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13367.9, + "Centroid Y µm": 19989.4, + "Num Detections": 8378, + "Num Negative": 8340, + "Num Positive": 38, + "Positive %": 0.4536, + "Num Positive per mm^2": 35.88 + } +} \ No newline at end of file diff --git a/668/TumorCenter_CD8_block1_x3_y6_patient668_0.json b/668/TumorCenter_CD8_block1_x3_y6_patient668_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3ea57094d3ea7f5cf4f9256a5ce5613e0d8e189d --- /dev/null +++ b/668/TumorCenter_CD8_block1_x3_y6_patient668_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 23937.3, + "Num Detections": 24982, + "Num Negative": 21632, + "Num Positive": 3350, + "Positive %": 13.41, + "Num Positive per mm^2": 1439.8 + } +} \ No newline at end of file diff --git a/668/TumorCenter_CD8_block1_x4_y6_patient668_1.json b/668/TumorCenter_CD8_block1_x4_y6_patient668_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0affcf1e7ce763ac43045c8922f476379a7b7938 --- /dev/null +++ b/668/TumorCenter_CD8_block1_x4_y6_patient668_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 23862.4, + "Num Detections": 20118, + "Num Negative": 19446, + "Num Positive": 672, + "Positive %": 3.34, + "Num Positive per mm^2": 342.94 + } +} \ No newline at end of file diff --git a/668/history_text.txt b/668/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef62db0b024fc58fb73467c180800498c3a60806 --- /dev/null +++ b/668/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed p16-positive cervical lymph node metastasis on the left cervical side. The preoperative PET-CT shows an increase in the left tonsil area. There is now an indication for panendoscopy and tumor tonsillectomy on the left side. The patient had sufficient time to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/668/icd_codes.txt b/668/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eea8583c2896d83437fc46838a3cfc7af2ea242f --- /dev/null +++ b/668/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Gaumenbogentonsillen[C09.1 L] \ No newline at end of file diff --git a/668/ops_codes.txt b/668/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aade48877ad4aab1a7cd5d63ce6ee6324027a1c7 --- /dev/null +++ b/668/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/668/patient_clinical_data.json b/668/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0e2e007ea56955194497abe64d779aa9b53d2ac6 --- /dev/null +++ b/668/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 76, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/668/patient_pathological_data.json b/668/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6215a63efc13653437dd9ec0a34dff2f51c41395 --- /dev/null +++ b/668/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "668", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 14, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/668/surgery_description.txt b/668/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7751c7d394c35fb81d906da1e27ae4a3ef4f0dac --- /dev/null +++ b/668/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy and Panendoscopy diff --git a/668/surgery_report.txt b/668/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e7b6703d4d6849ac245677eb5fc4558319b619b --- /dev/null +++ b/668/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia and transition to rigid tracheoscopy. Problem-free passage of the non-irritated glottis and endotracheal entry. Mucosal conditions are unremarkable on all sides up to the bifurcation. Intubation of the patient by the surgeon. Transition to esophagogastroscopy. Insertion of the endoscope under visualization and constant air insufflation into the stomach. This reveals a typical gastric mucosal relief without irritation on all sides. Inversion and inspection of the gastroesophageal junction. This also appears unremarkable. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. Here, too, there is no evidence of a tumor. Remove the endoscope and position the patient in head reclination. Insert the mouth guard and enter with the size C small bore tube. First, adjust the endolarynx. This is inconspicuous. The same applies to the hypopharynx on both sides, the postcricoid region and the esophageal entrance. Inspection of the oropharynx, the oral cavity and the oral vestibule. In the area of the left tonsil at the caudal tonsil pole, there is a clearly contact-vulnerable, highly visible change in the mucosa. However, this appears to be limited to the tonsil. Therefore, insertion of the MvIvor oral spatula while protecting the teeth, lips and tongue and proceeding to tumor tonsillectomy. The entry is cranial, parauvular. A tumor tonsillectomy is then performed, taking away the muscles in the area of the palatal arches and the lateral tonsil lobe. Due to the clearly medialized position of the internal carotid artery, extreme care must be taken during dissection. There is moderate pulsating arterial bleeding in two places, which can be treated primarily by bipolar coagulation and later by repositioning. The caudal dissection is continued to the base of the tongue in order to ensure an in sano resection macroscopically. After removal of the tumor specimen, the sutures are marked in the area of the anterior palatal arch, the posterior palatal arch, the lower tonsil pole and the base of the wound. Macroscopically, the tumor is relatively close to the margin of the resection in the area of the caudal resection margin. Therefore, a corresponding resection specimen and a margin specimen are taken. The samples are sent for frozen section diagnostics. The tumor is sano-resected when the findings are transmitted by telephone. Only in the area of the wound bed towards the lateral side is the resection barely in sano. It was therefore decided to take a corresponding marginal sample here. As the internal carotid artery is directly adjacent to the area of the resection, all preparatory steps are extremely meticulous. Removal of an extensive resection so that parapharyngeal fat is partially exposed. During the post-resection, there is also heavy arterial bleeding in two places, which can initially be coagulated bipolarly. The post-resection specimen is sent for definitive histology. Due to the repeated increase in bleeding in the area of the lateral tonsil bed and the position of the internal carotid artery already described, the decision is now made to adapt the musculature in the area of the lateral tonsil lobe in two layers. The same is done again at the mucosal level in the area of the anterior and posterior palatal arch. The sutures here are made with Vicryl 3.0 RB1. At the end of the operation, persistently dry wound conditions. Final consultation with the anesthesiologist. Completion of the operation without complications. \ No newline at end of file diff --git a/669/InvasionFront_CD3_block20_x1_y8_patient669_0.json b/669/InvasionFront_CD3_block20_x1_y8_patient669_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8cc5001a751c86a240ea19cec3ffc43909b368a2 --- /dev/null +++ b/669/InvasionFront_CD3_block20_x1_y8_patient669_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4472.6, + "Centroid Y µm": 19289.8, + "Num Detections": 19225, + "Num Negative": 19066, + "Num Positive": 159, + "Positive %": 0.827, + "Num Positive per mm^2": 73.74 + } +} \ No newline at end of file diff --git a/669/InvasionFront_CD3_block20_x2_y8_patient669_1.json b/669/InvasionFront_CD3_block20_x2_y8_patient669_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fe91b58f5f336d891d858589b96780acf6d2f0d2 --- /dev/null +++ b/669/InvasionFront_CD3_block20_x2_y8_patient669_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7021.3, + "Centroid Y µm": 19439.7, + "Num Detections": 17668, + "Num Negative": 17328, + "Num Positive": 340, + "Positive %": 1.924, + "Num Positive per mm^2": 152.34 + } +} \ No newline at end of file diff --git a/669/InvasionFront_CD8_block20_x1_y8_patient669_0.json b/669/InvasionFront_CD8_block20_x1_y8_patient669_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bfaf0f82c6d9a9fbb2e5f4ed1b26fed227847ed8 --- /dev/null +++ b/669/InvasionFront_CD8_block20_x1_y8_patient669_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4623.1, + "Centroid Y µm": 20584.8, + "Num Detections": 12460, + "Num Negative": 12154, + "Num Positive": 306, + "Positive %": 2.456, + "Num Positive per mm^2": 221.42 + } +} \ No newline at end of file diff --git a/669/InvasionFront_CD8_block20_x2_y8_patient669_1.json b/669/InvasionFront_CD8_block20_x2_y8_patient669_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e3b3b053a65826d8827417de1fcdcf1d9987dd9 --- /dev/null +++ b/669/InvasionFront_CD8_block20_x2_y8_patient669_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7165.6, + "Centroid Y µm": 20442.8, + "Num Detections": 6018, + "Num Negative": 5754, + "Num Positive": 264, + "Positive %": 4.387, + "Num Positive per mm^2": 403.2 + } +} \ No newline at end of file diff --git a/669/TumorCenter_CD3_block20_x1_y8_patient669_0.json b/669/TumorCenter_CD3_block20_x1_y8_patient669_0.json new file mode 100644 index 0000000000000000000000000000000000000000..04fce1d3098e2a0335bf14245082c387158118ac --- /dev/null +++ b/669/TumorCenter_CD3_block20_x1_y8_patient669_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3662.3, + "Centroid Y µm": 19197.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/669/TumorCenter_CD3_block20_x2_y8_patient669_1.json b/669/TumorCenter_CD3_block20_x2_y8_patient669_1.json new file mode 100644 index 0000000000000000000000000000000000000000..281a77a5300a453f04b9e7d3e8143e3582dac2c7 --- /dev/null +++ b/669/TumorCenter_CD3_block20_x2_y8_patient669_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6245.0, + "Centroid Y µm": 19238.3, + "Num Detections": 17089, + "Num Negative": 16813, + "Num Positive": 276, + "Positive %": 1.615, + "Num Positive per mm^2": 118.4 + } +} \ No newline at end of file diff --git a/669/TumorCenter_CD8_block20_x1_y8_patient669_0.json b/669/TumorCenter_CD8_block20_x1_y8_patient669_0.json new file mode 100644 index 0000000000000000000000000000000000000000..784e51631a1b93b5f2bf145cf8cccaa66b31f2d9 --- /dev/null +++ b/669/TumorCenter_CD8_block20_x1_y8_patient669_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.5, + "Centroid Y µm": 20585.2, + "Num Detections": 12434, + "Num Negative": 12325, + "Num Positive": 109, + "Positive %": 0.8766, + "Num Positive per mm^2": 76.52 + } +} \ No newline at end of file diff --git a/669/TumorCenter_CD8_block20_x2_y8_patient669_1.json b/669/TumorCenter_CD8_block20_x2_y8_patient669_1.json new file mode 100644 index 0000000000000000000000000000000000000000..16d319fbbf4796ad7b1d7782f86fc6a5ab811c19 --- /dev/null +++ b/669/TumorCenter_CD8_block20_x2_y8_patient669_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 20276.8, + "Num Detections": 7643, + "Num Negative": 7273, + "Num Positive": 370, + "Positive %": 4.841, + "Num Positive per mm^2": 377.54 + } +} \ No newline at end of file diff --git a/669/history_text.txt b/669/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/669/icd_codes.txt b/669/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..31f58876b28caf6583e662fc242ecb509734f250 --- /dev/null +++ b/669/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 L] \ No newline at end of file diff --git a/669/ops_codes.txt b/669/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fec374b9535f08453447b823f5dde0fdd16e286e --- /dev/null +++ b/669/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie endoskopische Laserresektion[5-302.5 L] Diagnostische Mikrolaryngoskopie[1-610.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/669/patient_clinical_data.json b/669/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7660ca408a87c00c63945c049e4967113575df68 --- /dev/null +++ b/669/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/669/patient_pathological_data.json b/669/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..24808680ca0cc09b7cf877ac7e3d4c10d8d8b978 --- /dev/null +++ b/669/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "669", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.5 +} \ No newline at end of file diff --git a/669/surgery_description.txt b/669/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..994a8f5b8155bee125c408514fd7a3ac598a1b6a --- /dev/null +++ b/669/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Microlaryngoscopy diff --git a/669/surgery_report.txt b/669/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b5931acedeb7f90c74a965c47e313ffbc9e2cb6f --- /dev/null +++ b/669/surgery_report.txt @@ -0,0 +1 @@ +After an introductory consultation with the anesthesiologist, the patient is first positioned. Insertion of the size B small bore tube and visualization of the glottic plane. Use of the surgical microscope and support autoscopy. A strongly exophytic tumor of the left vocal fold can now be seen, which is limited to the left vocal fold but extends into the anterior commissure. The patient can be positioned relatively well so that there is a good overview of the tumor. Microlaryngoscopic laser ablation of the tumor is now performed. This begins dorsally with a safety margin of around 1-2 mm. In the lateral removal area, it extends deep into the vocalis muscle. The resection is performed anteriorly, where the tumor is dissected from the inner surface of the laryngeal cartilage and removed with the laser. The cartilage surface appears smooth and inconspicuous. The tumor extends a little way into the subglottic area, so that an appropriate safety margin of 2 mm must be maintained on the subglottic slope. Careful hemostasis is then performed. Take representative samples in the area of the anterior commissure as well as at the caudal margin. These are assessed intraoperatively as tumor-free by the pathologist. The lateral cranial and dorsal settling area was macroscopically safe in sano. After repeated careful hemostasis, with dry wound conditions, removal of all instruments. Final consultation with the anesthesiologist. Due to the direct attachment of the tumor in the anterior commissure, close monitoring, including microlaryngoscopy, is urgently required for tumor follow-up. \ No newline at end of file diff --git a/670/InvasionFront_CD3_block2_x1_y12_patient670_0.json b/670/InvasionFront_CD3_block2_x1_y12_patient670_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1776929ce95f80c3a473d727dd8ead5bda497f9c --- /dev/null +++ b/670/InvasionFront_CD3_block2_x1_y12_patient670_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6021.8, + "Centroid Y µm": 43252.1, + "Num Detections": 24248, + "Num Negative": 23378, + "Num Positive": 870, + "Positive %": 3.588, + "Num Positive per mm^2": 342.62 + } +} \ No newline at end of file diff --git a/670/InvasionFront_CD3_block2_x2_y12_patient670_1.json b/670/InvasionFront_CD3_block2_x2_y12_patient670_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54ff30354f86b767e763735fbe5eddeb01388588 --- /dev/null +++ b/670/InvasionFront_CD3_block2_x2_y12_patient670_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8645.4, + "Centroid Y µm": 43302.1, + "Num Detections": 21522, + "Num Negative": 20964, + "Num Positive": 558, + "Positive %": 2.593, + "Num Positive per mm^2": 222.92 + } +} \ No newline at end of file diff --git a/670/InvasionFront_CD8_block2_x1_y12_patient670_0.json b/670/InvasionFront_CD8_block2_x1_y12_patient670_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f731de4ee6c3ad8ce5c1f567a200b208bd38be91 --- /dev/null +++ b/670/InvasionFront_CD8_block2_x1_y12_patient670_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4845.2, + "Centroid Y µm": 30313.3, + "Num Detections": 12407, + "Num Negative": 12308, + "Num Positive": 99, + "Positive %": 0.7979, + "Num Positive per mm^2": 67.33 + } +} \ No newline at end of file diff --git a/670/InvasionFront_CD8_block2_x2_y12_patient670_1.json b/670/InvasionFront_CD8_block2_x2_y12_patient670_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd349b0014c3b7636ff3638c6bcb4e9974af87c9 --- /dev/null +++ b/670/InvasionFront_CD8_block2_x2_y12_patient670_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7337.1, + "Centroid Y µm": 30729.1, + "Num Detections": 17086, + "Num Negative": 17020, + "Num Positive": 66, + "Positive %": 0.3863, + "Num Positive per mm^2": 35.21 + } +} \ No newline at end of file diff --git a/670/TumorCenter_CD3_block2_x1_y12_patient670_0.json b/670/TumorCenter_CD3_block2_x1_y12_patient670_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8272c3871cb0e676efc60ece452e7587d40827f4 --- /dev/null +++ b/670/TumorCenter_CD3_block2_x1_y12_patient670_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3398.2, + "Centroid Y µm": 29109.6, + "Num Detections": 9824, + "Num Negative": 9673, + "Num Positive": 151, + "Positive %": 1.537, + "Num Positive per mm^2": 121.46 + } +} \ No newline at end of file diff --git a/670/TumorCenter_CD3_block2_x2_y12_patient670_1.json b/670/TumorCenter_CD3_block2_x2_y12_patient670_1.json new file mode 100644 index 0000000000000000000000000000000000000000..511b33a2dcf1f89bd5faec245dead26907dcd7fc --- /dev/null +++ b/670/TumorCenter_CD3_block2_x2_y12_patient670_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5946.9, + "Centroid Y µm": 29209.5, + "Num Detections": 20650, + "Num Negative": 19633, + "Num Positive": 1017, + "Positive %": 4.925, + "Num Positive per mm^2": 443.73 + } +} \ No newline at end of file diff --git a/670/TumorCenter_CD8_block2_x1_y12_patient670_0.json b/670/TumorCenter_CD8_block2_x1_y12_patient670_0.json new file mode 100644 index 0000000000000000000000000000000000000000..38772bb0cb988a294830686aa88ec7cb228ec82f --- /dev/null +++ b/670/TumorCenter_CD8_block2_x1_y12_patient670_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6032.2, + "Centroid Y µm": 29726.1, + "Num Detections": 10189, + "Num Negative": 10177, + "Num Positive": 12, + "Positive %": 0.1178, + "Num Positive per mm^2": 9.009 + } +} \ No newline at end of file diff --git a/670/TumorCenter_CD8_block2_x2_y12_patient670_1.json b/670/TumorCenter_CD8_block2_x2_y12_patient670_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5187c2852d4a3cdf11910be1a82f3f32cda71f21 --- /dev/null +++ b/670/TumorCenter_CD8_block2_x2_y12_patient670_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8545.5, + "Centroid Y µm": 29684.3, + "Num Detections": 21203, + "Num Negative": 21168, + "Num Positive": 35, + "Positive %": 0.1651, + "Num Positive per mm^2": 14.76 + } +} \ No newline at end of file diff --git a/670/history_text.txt b/670/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..52314493aa9df55cc3aadd74639c18ce724a833a --- /dev/null +++ b/670/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: mass in the area of the posterior hypopharyngeal wall, localized on the right side extending to the midline. No definite infiltration detectable on CT. \ No newline at end of file diff --git a/670/icd_codes.txt b/670/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2405a3a2a1f520660c5cade89c8e5753d0d51ba7 --- /dev/null +++ b/670/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] \ No newline at end of file diff --git a/670/ops_codes.txt b/670/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..1886b98e84e86c7d53f2f221dfc320f7b860969c --- /dev/null +++ b/670/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Exzision, lokal[5-292.0 ] \ No newline at end of file diff --git a/670/patient_clinical_data.json b/670/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..81cad2b51e005fda71655e6e394df8774287a448 --- /dev/null +++ b/670/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/670/patient_pathological_data.json b/670/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c3fa776c897a828a00a5c0e73b19986dd541aff4 --- /dev/null +++ b/670/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "670", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "TX", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/670/surgery_description.txt b/670/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab6802cce3ba6d869b2571e7fced1445d1df0d69 --- /dev/null +++ b/670/surgery_description.txt @@ -0,0 +1 @@ +Excisional biopsy, Panendoscopy diff --git a/670/surgery_report.txt b/670/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf5c7894a8314a7ccd50a4c8bc1a99977f3eb814 --- /dev/null +++ b/670/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Then advance the 0° scope through the glottic plane into the trachea. Advance the endoscope. Mucosal conditions are unremarkable on all sides up to the exit of the segmental bronchi during reflection. There were also no abnormalities in the subglottis, glottis and supraglottis. Now intubation of the patient. Inspection of the larynx. No special features in the area of the subglottis, glottis and supraglottis. Inspection of the oropharynx and oral cavity. No special features. After pulling up the soft palate, there are no special features in the nasopharynx. Inspection of the hypopharynx: There is a mucosal appearance in the area of the piriform sinus on both sides. In the area of the posterior pharyngeal wall, passing over to the right side, a papillomatous, broad-based structure can be seen above the arytenoid cartilage. This structure is most suspicious for a papilloma. Set-up of the CO2 laser and resection of this mucosal area as an excisional biopsy. Under the microscope, this papilloma is completely resected with the laser while sparing the muscles. Careful hemostasis. Dry conditions at the end of the operation. Further procedure depending on the histology. Final consultation with the anesthetist. Completion of the procedure. \ No newline at end of file diff --git a/671/InvasionFront_CD3_block2_x3_y8_patient671_0.json b/671/InvasionFront_CD3_block2_x3_y8_patient671_0.json new file mode 100644 index 0000000000000000000000000000000000000000..20bab7e5913f32b7b6499da8e2adcb079bf72a2f --- /dev/null +++ b/671/InvasionFront_CD3_block2_x3_y8_patient671_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 33332.4, + "Num Detections": 22116, + "Num Negative": 12011, + "Num Positive": 10105, + "Positive %": 45.69, + "Num Positive per mm^2": 4008.2 + } +} \ No newline at end of file diff --git a/671/InvasionFront_CD3_block2_x4_y8_patient671_1.json b/671/InvasionFront_CD3_block2_x4_y8_patient671_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8eb922ac7391d8202ca64e3f6da058377f179793 --- /dev/null +++ b/671/InvasionFront_CD3_block2_x4_y8_patient671_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16166.4, + "Centroid Y µm": 33482.3, + "Num Detections": 28955, + "Num Negative": 24525, + "Num Positive": 4430, + "Positive %": 15.3, + "Num Positive per mm^2": 1613.0 + } +} \ No newline at end of file diff --git a/671/InvasionFront_CD8_block2_x3_y8_patient671_0.json b/671/InvasionFront_CD8_block2_x3_y8_patient671_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3b843be0889fbbb284dd9a0acee44165f40f03f7 --- /dev/null +++ b/671/InvasionFront_CD8_block2_x3_y8_patient671_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12368.5, + "Centroid Y µm": 21038.9, + "Num Detections": 27378, + "Num Negative": 24298, + "Num Positive": 3080, + "Positive %": 11.25, + "Num Positive per mm^2": 1253.4 + } +} \ No newline at end of file diff --git a/671/InvasionFront_CD8_block2_x4_y8_patient671_1.json b/671/InvasionFront_CD8_block2_x4_y8_patient671_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c92bc02985e65dcad728e0a12a3b63c4fa21725 --- /dev/null +++ b/671/InvasionFront_CD8_block2_x4_y8_patient671_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14992.1, + "Centroid Y µm": 21238.8, + "Num Detections": 32091, + "Num Negative": 29328, + "Num Positive": 2763, + "Positive %": 8.61, + "Num Positive per mm^2": 1029.6 + } +} \ No newline at end of file diff --git a/671/TumorCenter_CD3_block2_x3_y8_patient671_0.json b/671/TumorCenter_CD3_block2_x3_y8_patient671_0.json new file mode 100644 index 0000000000000000000000000000000000000000..57855438e543a688a98fe5cf0cf786ac7929f2f8 --- /dev/null +++ b/671/TumorCenter_CD3_block2_x3_y8_patient671_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 19539.7, + "Num Detections": 22190, + "Num Negative": 11113, + "Num Positive": 11077, + "Positive %": 49.92, + "Num Positive per mm^2": 4656.9 + } +} \ No newline at end of file diff --git a/671/TumorCenter_CD3_block2_x4_y8_patient671_1.json b/671/TumorCenter_CD3_block2_x4_y8_patient671_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ffb90b350857de1af01e06a29eba19fc763ae1b5 --- /dev/null +++ b/671/TumorCenter_CD3_block2_x4_y8_patient671_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 19664.6, + "Num Detections": 22563, + "Num Negative": 11118, + "Num Positive": 11445, + "Positive %": 50.72, + "Num Positive per mm^2": 5031.8 + } +} \ No newline at end of file diff --git a/671/TumorCenter_CD8_block2_x3_y8_patient671_0.json b/671/TumorCenter_CD8_block2_x3_y8_patient671_0.json new file mode 100644 index 0000000000000000000000000000000000000000..956d45cde6fde4d3980eb89778d5d8d57802bddf --- /dev/null +++ b/671/TumorCenter_CD8_block2_x3_y8_patient671_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13168.0, + "Centroid Y µm": 19614.6, + "Num Detections": 29455, + "Num Negative": 25087, + "Num Positive": 4368, + "Positive %": 14.83, + "Num Positive per mm^2": 1797.5 + } +} \ No newline at end of file diff --git a/671/TumorCenter_CD8_block2_x4_y8_patient671_1.json b/671/TumorCenter_CD8_block2_x4_y8_patient671_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fae21e948404560382b337bac960901ca9990ac1 --- /dev/null +++ b/671/TumorCenter_CD8_block2_x4_y8_patient671_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15691.7, + "Centroid Y µm": 19589.6, + "Num Detections": 25883, + "Num Negative": 21076, + "Num Positive": 4807, + "Positive %": 18.57, + "Num Positive per mm^2": 2044.3 + } +} \ No newline at end of file diff --git a/671/history_text.txt b/671/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f8200959778881e66fa67e43fbba61d5e9e84d4e --- /dev/null +++ b/671/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the area of the tonsil G3 squamous cell carcinoma. The above-mentioned operation was therefore indicated. To be on the safe side, the patient was also informed about flap coverage in the event of a very large neck metastasis. \ No newline at end of file diff --git a/671/icd_codes.txt b/671/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ee366e399eadb334bc1c44cb30425187f0da201 --- /dev/null +++ b/671/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Tonsille mehrere Teilbereiche überlappend[C09.8 R] Zervikale Lymphknotenmetastase[C77.0 R] \ No newline at end of file diff --git a/671/ops_codes.txt b/671/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..af68b6193c5c33a6e6ef7581d258d45adcc53efe --- /dev/null +++ b/671/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Transorale Tumortonsillektomie[5-281.2 ] Radikale erweiterte Neck dissection in 5 Regionen[5-403.31 R] Selektive Neck dissection in 4 Regionen[5-403.03 L] Permanente Tracheostomaanlage[5-312.0 ] \ No newline at end of file diff --git a/671/patient_clinical_data.json b/671/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..113818d2da7176bd59dbdd72227791071e2278bd --- /dev/null +++ b/671/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/671/patient_pathological_data.json b/671/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1156991843859e16a0a0f7b0ec9ae173e3f28e7c --- /dev/null +++ b/671/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "671", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 57, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/671/surgery_description.txt b/671/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e113a0cd3585a11900fd89a779e0c65efc33238d --- /dev/null +++ b/671/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Bilateral neck dissection, Tracheotomy diff --git a/671/surgery_report.txt b/671/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c27d59c0b34bbc5dea5c23ebac04706ab695169b --- /dev/null +++ b/671/surgery_report.txt @@ -0,0 +1 @@ +First, oral cavity inspection again. Pharyngoscopy and laryngoscopy: The relatively inconspicuous and flat tumor is seen in the area of the tonsil lobe, which is also somewhat hardened. No growth in the tonsillar lobe. Tumor also well mobile. Indication for surgery therefore given. PEG insertion: insertion of the flexible esophagoscope, after creation of the diaphanoscopy insertion of a 15 mm abdominal wall tube without complications. Fixation to the abdominal wall in the typical manner. Now first insertion of the Mc Ivor blade. The tumor is incised with a safety margin of at least 1 cm on all sides, also in depth. The anterior palatal arch, the tonsil and parts of the base of the tongue and the glossotonsillar groove are removed. The posterior palatal arch remains almost intact. The specimen is removed, thread-marked and sent for frozen section. Tumor-free on all sides in the frozen section. Thus R0 situation with regard to the primary tumor. Careful hemostasis. Now repositioning for neck dissection on both sides and tracheotomy. Beginning with neck dissection on the right: skin incision in typical manner. Exposure of the sternocleidomastoid muscle. The mass is located cranially and is relatively difficult to move. Infiltration into the soft tissue is to be expected here. As the dissection progresses, it becomes apparent that the mass is growing up to the lower tonsil pole, which is also resected. Also infiltration of the sternocleidomastoid muscle, the internal jugular vein and parts of the branches of the cervical plexus. First presentation of the omohyoid muscle and digastric muscle. The latter must be resected laterally as it is infiltrated. Visualization of the internal jugular vein. It can be visualized caudally, cranially it is clearly infiltrated by the tumor. Depiction of the internal and external carotid artery. The external artery is infiltrated at its outlets. The branches are successively dissected and ligated. The course of the external artery can be preserved up to the parotid gland. The superficial temporal vein is ligated. The facial vein is also ligated. In the area of the bulb and the internal carotid artery, the lymph node conglomerate lies close to these structures. Difficult dissection of the internal carotid artery, which is exposed up to the base of the skull in order to dissect the tumor. However, this is completely successful. No evidence of real infiltration of the wall. Clear tumor infiltration in the area of the hypoglossus, which is also resected. The vagus nerve is also located in the tumor conglomerate and is also thickened. Therefore co-resection. Also resection of the accessorius nerve. Upper parts of the cervical plexus branches must also be partially resected. The phrenic nerve can be preserved, as can the lower parts which extend supraclavicularly. In addition to the large lymph node conglomerate, there are multiple other lymph nodes between the branches of the cervical plexus. A resection up to level Vb and level IIb followed, with complete removal of levels II to V. In the course of the procedure, the caudal parotid pole was resected to confirm a resection in healthy tissue. This also included visualization of the oral branch, which can be preserved. Also marginal samples from the cranial accessorius and vagus area. These marginal samples are healthy. Overall, however, in addition to the large lymph node metastasis conglomerate with clear soft tissue infiltration, multiple metastases level II, III, IV, V. Careful hemostasis, irrigation with hydrogen and Ringer's solution. Wound closure in layers with insertion of a Redon drain. Due to the extensive metastasis in the neck region on the right, neck dissection on the left is now indicated. Tracheotomy also indicated due to the extensive resection of the important structures on the right side of the neck. Left neck dissection and tracheotomy (, ). Marking of the planned skin incision on the left, curving from mastoid to caudal along the anterior edge of the sternocleidomastoid. Marking of mandibular angle and mandibular branch. Skin incision using a scalpel through the subcutaneous tissue and platysma. Separation of the platysma. Development of a skin flap by successive dissection along the platysma. Exposure of the sternocleidomastoid anterior margin. Exposure of the internal jugular vein, the accessorius nerve. Exposure and dissection of the omohyoid muscle, the submandibular gland and the anterior posterior digastric venter. Exposure of the hypoglossal nerve. Exposure of the ansa, free preparation of the internal jugular vein and the facial vein as well as other outlets to obtain venous drainage. Development of the medial neck preparation and resection of the same. The superior thyroid artery cannot be spared here; it is ligated and clipped. Now dissect the lateral neck specimen. To do this, expose the common carotid artery and the vagus. Dissection from caudal to cranial, taking level V to Ib. The ansa is visualized as well as the plexus, which is spared. No evidence of hilar fistula. Removal of the neck preparation. Hemostasis, irrigation with H202 and Ringer. Insertion of a 10-gauge Redon. Two-layer wound closure. Subsequent tracheotomy. For this purpose, marking of the skin incision 1 QF below the cricoid cartilage, skin incision of approx. 3 cm, dissection through cutaneous and subcutaneous tissue, ligation of larger caliber veins. Exposure of the linea alba and pushing the infrahyoid muscles to the side. Dissection on the cricoid cartilage. Exposure of the anterior surface of the trachea. Exposure of the narrow glandular isthmus, which is undermined and extensively bipolarized. Truncus brachiocephalicus is not palpable. Now create a Björk flap between the 2nd and 3rd tracheal clasp, this is successful without any problems. Suturing of the same using a total of 5 stoma sutures. Insertion of an 8 mm cannula and problem-free reintubation. Re-inspection of the right neck, here again bipolar coagulation. Irrigation with H202. Insertion of a 10-gauge Redon and two-layer wound closure. Finally, cT1-2 tonsillar carcinoma removed in healthy tissue. Extensive neck metastasis on the right with multiple metastases under a very large metastatic conglomerate. Postoperatively, the patient is admitted to the intensive care unit for one night for monitoring. Please continue antibiotics started intraoperatively. Plan further procedure after receiving the final histology. RCT is most likely indicated. \ No newline at end of file diff --git a/672/InvasionFront_CD3_block5_x5_y2_patient672_0.json b/672/InvasionFront_CD3_block5_x5_y2_patient672_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c2eb638d265d29cdef4519bceff6c5bbd55e3942 --- /dev/null +++ b/672/InvasionFront_CD3_block5_x5_y2_patient672_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 4997.4, + "Num Detections": 26826, + "Num Negative": 26077, + "Num Positive": 749, + "Positive %": 2.792, + "Num Positive per mm^2": 257.05 + } +} \ No newline at end of file diff --git a/672/InvasionFront_CD3_block5_x6_y2_patient672_1.json b/672/InvasionFront_CD3_block5_x6_y2_patient672_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0d5553201c78bf504623a1d7d0102dfe1d2d87ff --- /dev/null +++ b/672/InvasionFront_CD3_block5_x6_y2_patient672_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19114.9, + "Centroid Y µm": 5022.3, + "Num Detections": 21302, + "Num Negative": 20490, + "Num Positive": 812, + "Positive %": 3.812, + "Num Positive per mm^2": 338.4 + } +} \ No newline at end of file diff --git a/672/InvasionFront_CD8_block5_x5_y2_patient672_0.json b/672/InvasionFront_CD8_block5_x5_y2_patient672_0.json new file mode 100644 index 0000000000000000000000000000000000000000..94bbbf676b14522463b0742a53314cebfb966b00 --- /dev/null +++ b/672/InvasionFront_CD8_block5_x5_y2_patient672_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16041.5, + "Centroid Y µm": 4997.4, + "Num Detections": 26839, + "Num Negative": 26438, + "Num Positive": 401, + "Positive %": 1.494, + "Num Positive per mm^2": 140.54 + } +} \ No newline at end of file diff --git a/672/InvasionFront_CD8_block5_x6_y2_patient672_1.json b/672/InvasionFront_CD8_block5_x6_y2_patient672_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c6cdbd89adc4c4c3fde16b8c33fce2dcee0182d --- /dev/null +++ b/672/InvasionFront_CD8_block5_x6_y2_patient672_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 4997.4, + "Num Detections": 20516, + "Num Negative": 20277, + "Num Positive": 239, + "Positive %": 1.165, + "Num Positive per mm^2": 108.62 + } +} \ No newline at end of file diff --git a/672/TumorCenter_CD3_block5_x5_y2_patient672_0.json b/672/TumorCenter_CD3_block5_x5_y2_patient672_0.json new file mode 100644 index 0000000000000000000000000000000000000000..252e4a74df8353b63914a6468be0942443037a6a --- /dev/null +++ b/672/TumorCenter_CD3_block5_x5_y2_patient672_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18065.4, + "Centroid Y µm": 5422.1, + "Num Detections": 24256, + "Num Negative": 23676, + "Num Positive": 580, + "Positive %": 2.391, + "Num Positive per mm^2": 215.83 + } +} \ No newline at end of file diff --git a/672/TumorCenter_CD3_block5_x6_y2_patient672_1.json b/672/TumorCenter_CD3_block5_x6_y2_patient672_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ee1f292345990ae57fb3ac77d927f5944f3ef04f --- /dev/null +++ b/672/TumorCenter_CD3_block5_x6_y2_patient672_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20639.1, + "Centroid Y µm": 5697.0, + "Num Detections": 22801, + "Num Negative": 21404, + "Num Positive": 1397, + "Positive %": 6.127, + "Num Positive per mm^2": 521.51 + } +} \ No newline at end of file diff --git a/672/TumorCenter_CD8_block5_x5_y2_patient672_0.json b/672/TumorCenter_CD8_block5_x5_y2_patient672_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e2beafd2f3421ebbb61210e632c6bf3315d9afb4 --- /dev/null +++ b/672/TumorCenter_CD8_block5_x5_y2_patient672_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16466.3, + "Centroid Y µm": 5047.3, + "Num Detections": 26684, + "Num Negative": 26060, + "Num Positive": 624, + "Positive %": 2.338, + "Num Positive per mm^2": 225.86 + } +} \ No newline at end of file diff --git a/672/TumorCenter_CD8_block5_x6_y2_patient672_1.json b/672/TumorCenter_CD8_block5_x6_y2_patient672_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6efa7ca6f671ba692482a92be0c39935822ec85d --- /dev/null +++ b/672/TumorCenter_CD8_block5_x6_y2_patient672_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 5172.3, + "Num Detections": 24922, + "Num Negative": 23582, + "Num Positive": 1340, + "Positive %": 5.377, + "Num Positive per mm^2": 488.04 + } +} \ No newline at end of file diff --git a/672/history_text.txt b/672/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d0e37d5c2bcc0c0133dee97be510ee36c64788d --- /dev/null +++ b/672/history_text.txt @@ -0,0 +1 @@ +Patient with confirmed squamous cell carcinoma in the area of the medial wall of the piriform sinus and the anterior wall of the piriform sinus on the right. In addition, cervical lymph node metastases on the right cervical side. Thus cT2 N2b hypopharyngeal carcinoma on the right with indication for the above-mentioned measures. \ No newline at end of file diff --git a/672/icd_codes.txt b/672/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ad33eae46dad3f98e5ea89f5dc2479b3ecf060ef --- /dev/null +++ b/672/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/672/ops_codes.txt b/672/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..51966f96dc1b47e859fbefabe86f9b2be981a5b5 --- /dev/null +++ b/672/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Mikrolaryngoskopie[1-610.2 ] Partielle Laryngektomie endoskopische Laserresektion[5-302.5 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie[5-312.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/672/patient_clinical_data.json b/672/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b5d605723c29f3e7ff9c96ae19a0c13af8269e10 --- /dev/null +++ b/672/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 43, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 51, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/672/patient_pathological_data.json b/672/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f1ee0f6370da6e21ba4cb98b998aa597ef78ca1e --- /dev/null +++ b/672/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "672", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/672/surgery_description.txt b/672/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..671c1c12d3747daeb0f1d9452a5724f874f2fa7d --- /dev/null +++ b/672/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Neck dissection, and Tracheotomy diff --git a/672/surgery_report.txt b/672/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..de4f11aedbbe367a6e7d533e853748919456139e --- /dev/null +++ b/672/surgery_report.txt @@ -0,0 +1 @@ +First, induction of anesthesia and transoral endotracheal intubation using a laser tube by the anesthesia colleagues and positioning of the patient by the surgeon. First, the larynx and pharynx were entered using a Kleinsasser C-tube and the findings were inspected. This revealed an exophytic, slightly exulcerated mass originating from the right aryepiglottic fold, affecting the cranial part of the medial wall of the right piriform sinus, clearly infiltrating the anterior wall of the right piriform sinus, but sparing the lateral wall of the piriform sinus as well as the esophageal entrance and the posterior wall of the hypopharynx. Thus V.a. cT2 hypopharyngeal carcinoma on the right side. Setting the CO2 laser to a power of 6 watts in continuous mode. Avoidance of the lesion and problem-free resection of the lesion using a piecemeal technique. Hemostasis using monopolar coagulation. Subsequently, 4 marginal samples were taken (right aryepiglottic fold, anterior wall of the piriform sinus, lateral wall of the piriform sinus, caudal area of the medial wall of the piriform sinus). All 4 marginal samples were found to be tumor-free by the pathology colleagues. An R0 resection can therefore be assumed. Repeated inspection. Dry conditions. The patient was then repositioned on the right side for the neck dissection. Skin spray disinfection, application of local anesthesia, skin ablation and sterile draping. First make a skin incision. Cut through the subcutaneous tissue and the platysma. Exposure and ligation of the external jugular vein. Creation of a subplatysmal flap in a cranial and caudal direction. Exposure and sparing of the cranial auricular nerve. Exposure of the accessorius nerve, the posterior venter of the digastric muscle and the omohyoid muscle. Dissection along the internal jugular vein from caudal to cranial. Dissection along the entire cervical vascular sheath. At least 3 masses were then visualized along the internal jugular vein, which appeared highly suspicious. Successive removal of the posterior neck specimen while sparing the above-mentioned structures and the plexus branches. Removal of the anterior neck preparation and thus evacuation of regions I b, II, III, IV and V. Hemostasis there by means of bipolar coagulation. Irrigation of the wound using hydrogen peroxide and Ringer's solution. Dry conditions. Application of a 10 Redon drainage, two-layer wound closure. Subsequent creation of an approx. 4 cm long incision along the lower edge of the cricoid cartilage. Separation of the subcutaneous tissue and platysma. Exposure and transection of the prelaryngeal musculature in the midline. Exposure of the thyroid isthmus, which is undermined and severed after treatment using bipolar coagulation. Exposure of the anterior wall of the trachea. Creation of a transverse incision between the 2nd and 3rd tracheal cartilage clasp. Formation of a Björk flap. Epithelialization of the tracheostoma. Skin suture and transfer of the patient to a size 8 Rügheimer cannula. Repositioning of the patient to perform a neck dissection on the left side. Skin incision. Dissection of the subcutaneous tissue and the platysma. Exposure of the auricular nerve. Exposure and ligation of the external jugular vein. Exposure of the accessorius nerve, the posterior venter of the digastric muscle and the omohyoid muscle. Exposure of the internal jugular vein, the vagus nerve and the common carotid artery. Dissection along the cervical vascular sheath from caudal to cranial. Successive removal of the posterior neck preparation. Subsequent removal of the anterior neck specimen. There were 2 conspicuous lymph nodes at the level of the upper venous angle. Dry conditions after hemostasis using bipolar coagulation. Wound irrigation with hydrogen peroxide and Ringer's solution. Placement of a 10 Redon drain, two-layer wound closure. Subsequent re-inspection of the hypopharynx on the right using a Kleinsasser C-tube. Dry conditions there. Removal of the small water tube and completion of the procedure without complications. \ No newline at end of file diff --git a/673/InvasionFront_CD3_block21_x3_y11_patient673_0.json b/673/InvasionFront_CD3_block21_x3_y11_patient673_0.json new file mode 100644 index 0000000000000000000000000000000000000000..657c0ac5b224e879b44537b47b6d3cb8e0814bbd --- /dev/null +++ b/673/InvasionFront_CD3_block21_x3_y11_patient673_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12493.4, + "Centroid Y µm": 38179.8, + "Num Detections": 23679, + "Num Negative": 23016, + "Num Positive": 663, + "Positive %": 2.8, + "Num Positive per mm^2": 286.08 + } +} \ No newline at end of file diff --git a/673/InvasionFront_CD3_block21_x4_y11_patient673_1.json b/673/InvasionFront_CD3_block21_x4_y11_patient673_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c99cda51c0ab181f0adc699a64d16a7020412139 --- /dev/null +++ b/673/InvasionFront_CD3_block21_x4_y11_patient673_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15566.8, + "Centroid Y µm": 38254.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/673/InvasionFront_CD8_block21_x3_y11_patient673_0.json b/673/InvasionFront_CD8_block21_x3_y11_patient673_0.json new file mode 100644 index 0000000000000000000000000000000000000000..952a94f7f9b157fc7a34cf065c752f33135fa7df --- /dev/null +++ b/673/InvasionFront_CD8_block21_x3_y11_patient673_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 27035.7, + "Num Detections": 24453, + "Num Negative": 23780, + "Num Positive": 673, + "Positive %": 2.752, + "Num Positive per mm^2": 286.8 + } +} \ No newline at end of file diff --git a/673/InvasionFront_CD8_block21_x4_y11_patient673_1.json b/673/InvasionFront_CD8_block21_x4_y11_patient673_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cf2eab750462130f5b06b280509bb291296df561 --- /dev/null +++ b/673/InvasionFront_CD8_block21_x4_y11_patient673_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 26860.8, + "Num Detections": 7704, + "Num Negative": 7331, + "Num Positive": 373, + "Positive %": 4.842, + "Num Positive per mm^2": 448.79 + } +} \ No newline at end of file diff --git a/673/TumorCenter_CD3_block21_x3_y11_patient673_0.json b/673/TumorCenter_CD3_block21_x3_y11_patient673_0.json new file mode 100644 index 0000000000000000000000000000000000000000..23da4cff589871d3bde324e3714364b66bc65ceb --- /dev/null +++ b/673/TumorCenter_CD3_block21_x3_y11_patient673_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11131.2, + "Centroid Y µm": 29832.6, + "Num Detections": 6936, + "Num Negative": 6310, + "Num Positive": 626, + "Positive %": 9.025, + "Num Positive per mm^2": 625.73 + } +} \ No newline at end of file diff --git a/673/TumorCenter_CD3_block21_x4_y11_patient673_1.json b/673/TumorCenter_CD3_block21_x4_y11_patient673_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69db39b50b1b71b89b96491e2c149762719e06dd --- /dev/null +++ b/673/TumorCenter_CD3_block21_x4_y11_patient673_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13513.9, + "Centroid Y µm": 29939.8, + "Num Detections": 2696, + "Num Negative": 2333, + "Num Positive": 363, + "Positive %": 13.46, + "Num Positive per mm^2": 1072.6 + } +} \ No newline at end of file diff --git a/673/TumorCenter_CD8_block21_x3_y11_patient673_0.json b/673/TumorCenter_CD8_block21_x3_y11_patient673_0.json new file mode 100644 index 0000000000000000000000000000000000000000..178138e6e0c09292e7d74371566c7740f2e1c2ca --- /dev/null +++ b/673/TumorCenter_CD8_block21_x3_y11_patient673_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12906.3, + "Centroid Y µm": 42042.2, + "Num Detections": 12871, + "Num Negative": 12218, + "Num Positive": 653, + "Positive %": 5.073, + "Num Positive per mm^2": 508.8 + } +} \ No newline at end of file diff --git a/673/TumorCenter_CD8_block21_x4_y11_patient673_1.json b/673/TumorCenter_CD8_block21_x4_y11_patient673_1.json new file mode 100644 index 0000000000000000000000000000000000000000..46822ea8628441fea5ebbe80d938667e614d0302 --- /dev/null +++ b/673/TumorCenter_CD8_block21_x4_y11_patient673_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15321.1, + "Centroid Y µm": 42149.0, + "Num Detections": 4785, + "Num Negative": 3718, + "Num Positive": 1067, + "Positive %": 22.3, + "Num Positive per mm^2": 2062.2 + } +} \ No newline at end of file diff --git a/673/history_text.txt b/673/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7165f73f04066a5cae6af440747dc66f719a94f1 --- /dev/null +++ b/673/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the epiglottis. \ No newline at end of file diff --git a/673/icd_codes.txt b/673/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/673/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/673/ops_codes.txt b/673/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..96c0649f871e83ead4875d7c094320da37ce1bf3 --- /dev/null +++ b/673/ops_codes.txt @@ -0,0 +1 @@ +Epiglottektomie endolaryngeal[5-302.0 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 4 Regionen[5-403.03 B] Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] \ No newline at end of file diff --git a/673/patient_clinical_data.json b/673/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a5a03013def0195f948d36f2435dfeb823cd7d42 --- /dev/null +++ b/673/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 59, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 2, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/673/patient_pathological_data.json b/673/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bd34c313f635be07cedbcb094507e3306ffe30a0 --- /dev/null +++ b/673/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "673", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/673/surgery_description.txt b/673/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f523d397060a029ecc629935ec40fdcc4a5141ca --- /dev/null +++ b/673/surgery_description.txt @@ -0,0 +1 @@ +Laser epiglottectomy endolaryngeal, Selective neck dissection, PEG diff --git a/673/surgery_report.txt b/673/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fe69dc026e8fb3793ac75eb3bdc361200d1f52d8 --- /dev/null +++ b/673/surgery_report.txt @@ -0,0 +1 @@ +Adjustment of the tumor with the small water tube. The laser is now used to clinically cut around the tumor in a healthy state. The free part of the epiglottis practically falls away completely. The resection extends to the base of the tongue on the left and the aryepiglottic fold on the left. The tumor is removed in toto. Overall difficult conditions due to the setting. Repeated bleeding, which makes dissection difficult. Removal of circular margin samples. These are found to be tumor-free in the frozen section. An R0 resection can be assumed. Now insertion of the PEG. To do this, insert the flexible endoscope into the esophagus. Advance into the stomach. Good diaphanoscopy. Some hyperplastic mucosa in the stomach, otherwise unremarkable conditions. Placement of the PEG with the thread pull-through method in the usual manner. No bleeding, no other special features. Now reposition the patient and perform neck dissection on both sides. Start with the left side. Infiltration anesthesia 3 times at the anterior border of the sternocleidomastoid muscle. Then skin incision. Dissection of the subcutaneous tissue. Exposure of the sternocleidomastoid muscle, the internal jugular vein, the accessorius nerve, the external, common and internal carotid artery and finally the internal jugular vein and facial vein. Dissection of the digastric muscle and clearing of the accessorius triangle. Exposure of the vagus nerve and removal of the posterior neck preparation - overall subtle preparation of a relatively large amount of subcutaneous tissue. Some bleeding makes dissection difficult. These are stopped with bipolar coagulation. Now dissection of the anterior part of the neck. Exposure of the hypoglossal nerve, the submandibular gland, removal of the capsule of the submandibular gland and removal of the anterior neck preparation while sparing the previously mentioned structures. Extensive hemostasis with H2O2. Bipolar coagulation. Irrigation with NaCl. No more bleeding. Insertion of a Redon drainage. Subcutaneous suture, skin suture, wound dressing. Now repositioning of the patient and neck dissection on the right. Here too, three infiltration anesthesia at the anterior edge of the sternocleidomastoid muscle. Now skin incision. Dissection of the muscle. Exposure of the internal jugular vein, the accessorius nerve, the common, external and internal carotid arteries and the vagus nerve. Dissection of the posterior digastric venter muscle. Very difficult dissection in the accessorius triangle. Finally, removal of the posterior neck preparation up to supraomohyoidal. Protection of the structures mentioned. Dissection anteriorly, dissection of the facial vein, exposure of the submandibular gland, removal of the capsule. Exposure of the hypoglossal nerve and the cervical nerve. Evacuation of the anterior neck preparation to the caudal side. Hemostasis with H2O2. Bipolar coagulation. No more bleeding. Insertion of a Redon drainage. Subcutaneous suture, skin suture, wound dressing. At the end of the procedure, control endoscopy and visualization of the resection area in the larynx. A small oozing hemorrhage is stopped with monopolar coagulation. No more bleeding now. No tracheotomy due to the still standing restepiglottis. Control in the intensive care unit. Intraoperative administration of Unacid and cortisone. \ No newline at end of file diff --git a/674/InvasionFront_CD3_block19_x1_y6_patient674_0.json b/674/InvasionFront_CD3_block19_x1_y6_patient674_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f06930d9b9d1b10130b5e0c81b9199054ca585bf --- /dev/null +++ b/674/InvasionFront_CD3_block19_x1_y6_patient674_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4572.6, + "Centroid Y µm": 16691.2, + "Num Detections": 23997, + "Num Negative": 22964, + "Num Positive": 1033, + "Positive %": 4.305, + "Num Positive per mm^2": 401.76 + } +} \ No newline at end of file diff --git a/674/InvasionFront_CD3_block19_x2_y6_patient674_1.json b/674/InvasionFront_CD3_block19_x2_y6_patient674_1.json new file mode 100644 index 0000000000000000000000000000000000000000..432d4a62cd909296a5ba37977bd9d7a421a9f4a4 --- /dev/null +++ b/674/InvasionFront_CD3_block19_x2_y6_patient674_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7271.2, + "Centroid Y µm": 16941.0, + "Num Detections": 21664, + "Num Negative": 20686, + "Num Positive": 978, + "Positive %": 4.514, + "Num Positive per mm^2": 388.4 + } +} \ No newline at end of file diff --git a/674/InvasionFront_CD8_block19_x1_y6_patient674_0.json b/674/InvasionFront_CD8_block19_x1_y6_patient674_0.json new file mode 100644 index 0000000000000000000000000000000000000000..62af93e6ccd9e529345faf780d35900bf48a5b4b --- /dev/null +++ b/674/InvasionFront_CD8_block19_x1_y6_patient674_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4447.6, + "Centroid Y µm": 24487.0, + "Num Detections": 15482, + "Num Negative": 15207, + "Num Positive": 275, + "Positive %": 1.776, + "Num Positive per mm^2": 161.62 + } +} \ No newline at end of file diff --git a/674/InvasionFront_CD8_block19_x2_y6_patient674_1.json b/674/InvasionFront_CD8_block19_x2_y6_patient674_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4b2fdb654d2aaaca350a736f007599affa6930d2 --- /dev/null +++ b/674/InvasionFront_CD8_block19_x2_y6_patient674_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 24487.0, + "Num Detections": 15606, + "Num Negative": 15325, + "Num Positive": 281, + "Positive %": 1.801, + "Num Positive per mm^2": 156.29 + } +} \ No newline at end of file diff --git a/674/TumorCenter_CD3_block19_x1_y6_patient674_0.json b/674/TumorCenter_CD3_block19_x1_y6_patient674_0.json new file mode 100644 index 0000000000000000000000000000000000000000..086e3b91c81c66f1d51f5ed187f44ce1f726f85c --- /dev/null +++ b/674/TumorCenter_CD3_block19_x1_y6_patient674_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4722.5, + "Centroid Y µm": 17265.9, + "Num Detections": 16010, + "Num Negative": 15592, + "Num Positive": 418, + "Positive %": 2.611, + "Num Positive per mm^2": 215.27 + } +} \ No newline at end of file diff --git a/674/TumorCenter_CD3_block19_x2_y6_patient674_1.json b/674/TumorCenter_CD3_block19_x2_y6_patient674_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d218870817717d4d7a39fa31cf1c319a7347c8bf --- /dev/null +++ b/674/TumorCenter_CD3_block19_x2_y6_patient674_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7171.2, + "Centroid Y µm": 16966.0, + "Num Detections": 19471, + "Num Negative": 19047, + "Num Positive": 424, + "Positive %": 2.178, + "Num Positive per mm^2": 164.49 + } +} \ No newline at end of file diff --git a/674/TumorCenter_CD8_block19_x1_y6_patient674_0.json b/674/TumorCenter_CD8_block19_x1_y6_patient674_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bfe954e816e59193c03d21a2010a19fbab9a95f3 --- /dev/null +++ b/674/TumorCenter_CD8_block19_x1_y6_patient674_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 26386.0, + "Num Detections": 23267, + "Num Negative": 22848, + "Num Positive": 419, + "Positive %": 1.801, + "Num Positive per mm^2": 174.64 + } +} \ No newline at end of file diff --git a/674/TumorCenter_CD8_block19_x2_y6_patient674_1.json b/674/TumorCenter_CD8_block19_x2_y6_patient674_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b1a95b44020b4223490aa8d90796fb34d3e6414b --- /dev/null +++ b/674/TumorCenter_CD8_block19_x2_y6_patient674_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8945.3, + "Centroid Y µm": 26311.1, + "Num Detections": 22790, + "Num Negative": 22249, + "Num Positive": 541, + "Positive %": 2.374, + "Num Positive per mm^2": 206.95 + } +} \ No newline at end of file diff --git a/674/history_text.txt b/674/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/674/icd_codes.txt b/674/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/674/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/674/ops_codes.txt b/674/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dff177eb8da18afbce99e9f2df4b59384f52331d --- /dev/null +++ b/674/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] \ No newline at end of file diff --git a/674/patient_clinical_data.json b/674/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8799d15d472052db3a6cbd4be9116c9577808761 --- /dev/null +++ b/674/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/674/patient_pathological_data.json b/674/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..93624d532d44cf1545ad2caa03944577b77c0942 --- /dev/null +++ b/674/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "674", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/674/surgery_description.txt b/674/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c44b0858e3be23d8d47b499373184bd5f823590d --- /dev/null +++ b/674/surgery_description.txt @@ -0,0 +1 @@ +Laryngeal partial resection from the outside in ITN diff --git a/674/surgery_report.txt b/674/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..477a1127c804239cbff7e1ced38bfbaa4f62f36e --- /dev/null +++ b/674/surgery_report.txt @@ -0,0 +1 @@ +After an introductory consultation with the anesthesia colleagues, first injection of local anesthetic with adrenaline prelaryngeally. Then zigzag-shaped skin incision and layered preparation in depth. Separation of the prelaryngeal muscles after ligation of some larger veins. Exposure of the laryngeal skeleton. Patial transection of the thyroid isthmus. Then transverse incision of the ligamentum conicum. Afterwards, the thyrofissure is cut with a saw. Opening of the larynx in the median line. Insertion of the retractors. The tumor can be exposed very well and reaches the anterior commissure. The tumor is now detached from the left vocal cord at the anterior commissure. Here, a marginal sample is taken, which is then assessed as tumor-free in a frozen section during the operation. Then further resection of the tumor on the right side. To do this, undermine the endolaryngeal perichondrium. This is then pushed off from the front. The tumor is incised on all sides with a safety margin of approx. 3 mm and can finally be completely resected with partial preservation of the vocalis muscle. The tumor is removed at the dorsal margin immediately in front of the vocalis process of the arytenoid cartilage. Now suture mark the specimen. As the specimen does not show a smooth wound margin at the caudal margin, an additional marginal sample is taken from the subglottal slope. The specimen and this marginal sample are also sent for frozen section diagnostics and are found to be tumor-free during the operation. Subsequent subtle hemostasis. Then, with dry wound conditions, closure of the thyrofissure with single button sutures after prior creation of a total of four drill holes. Then closure of the ligamentum conicum with single button sutures. Closure of the prelaryngeal muscles in the median line after insertion of a wound flap. Then two-layer wound closure and application of a pressure dressing. After a final consultation with the anesthesia colleagues, the patient can then be extubated without any problems. \ No newline at end of file diff --git a/675/InvasionFront_CD3_block12_x5_y11_patient675_0.json b/675/InvasionFront_CD3_block12_x5_y11_patient675_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e27aa4a1b153c1a0b079509cecb6ca6931b09d37 --- /dev/null +++ b/675/InvasionFront_CD3_block12_x5_y11_patient675_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 32407.8, + "Num Detections": 19470, + "Num Negative": 18646, + "Num Positive": 824, + "Positive %": 4.232, + "Num Positive per mm^2": 429.49 + } +} \ No newline at end of file diff --git a/675/InvasionFront_CD3_block12_x6_y11_patient675_1.json b/675/InvasionFront_CD3_block12_x6_y11_patient675_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd4f7baf8dde579182a127c4a7e0fe24d9b84795 --- /dev/null +++ b/675/InvasionFront_CD3_block12_x6_y11_patient675_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17940.5, + "Centroid Y µm": 32607.7, + "Num Detections": 19722, + "Num Negative": 18098, + "Num Positive": 1624, + "Positive %": 8.234, + "Num Positive per mm^2": 850.63 + } +} \ No newline at end of file diff --git a/675/InvasionFront_CD8_block12_x5_y11_patient675_0.json b/675/InvasionFront_CD8_block12_x5_y11_patient675_0.json new file mode 100644 index 0000000000000000000000000000000000000000..19992aa6868c1008621e766a7f33ee1a2ae9bd67 --- /dev/null +++ b/675/InvasionFront_CD8_block12_x5_y11_patient675_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17715.6, + "Centroid Y µm": 31133.5, + "Num Detections": 19108, + "Num Negative": 17474, + "Num Positive": 1634, + "Positive %": 8.551, + "Num Positive per mm^2": 839.62 + } +} \ No newline at end of file diff --git a/675/InvasionFront_CD8_block12_x6_y11_patient675_1.json b/675/InvasionFront_CD8_block12_x6_y11_patient675_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2a1a346913e068d77d1619b628707d37d123dad9 --- /dev/null +++ b/675/InvasionFront_CD8_block12_x6_y11_patient675_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20214.3, + "Centroid Y µm": 31008.6, + "Num Detections": 19180, + "Num Negative": 17542, + "Num Positive": 1638, + "Positive %": 8.54, + "Num Positive per mm^2": 843.19 + } +} \ No newline at end of file diff --git a/675/TumorCenter_CD3_block12_x5_y11_patient675_0.json b/675/TumorCenter_CD3_block12_x5_y11_patient675_0.json new file mode 100644 index 0000000000000000000000000000000000000000..27c4302b9dcabbd9babb9dec6fd22e0184556531 --- /dev/null +++ b/675/TumorCenter_CD3_block12_x5_y11_patient675_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15341.9, + "Centroid Y µm": 27410.5, + "Num Detections": 17849, + "Num Negative": 17065, + "Num Positive": 784, + "Positive %": 4.392, + "Num Positive per mm^2": 399.32 + } +} \ No newline at end of file diff --git a/675/TumorCenter_CD3_block12_x6_y11_patient675_1.json b/675/TumorCenter_CD3_block12_x6_y11_patient675_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1365d663304de2b5ce8b85e15f91845244682b15 --- /dev/null +++ b/675/TumorCenter_CD3_block12_x6_y11_patient675_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17765.6, + "Centroid Y µm": 27510.4, + "Num Detections": 13150, + "Num Negative": 12274, + "Num Positive": 876, + "Positive %": 6.662, + "Num Positive per mm^2": 529.18 + } +} \ No newline at end of file diff --git a/675/TumorCenter_CD8_block12_x5_y11_patient675_0.json b/675/TumorCenter_CD8_block12_x5_y11_patient675_0.json new file mode 100644 index 0000000000000000000000000000000000000000..548a88d822a94af7b49de8d95a824a6787a8d892 --- /dev/null +++ b/675/TumorCenter_CD8_block12_x5_y11_patient675_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 36905.5, + "Num Detections": 16807, + "Num Negative": 16227, + "Num Positive": 580, + "Positive %": 3.451, + "Num Positive per mm^2": 309.77 + } +} \ No newline at end of file diff --git a/675/TumorCenter_CD8_block12_x6_y11_patient675_1.json b/675/TumorCenter_CD8_block12_x6_y11_patient675_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cbb58a4f9a4c51c26d488d98b38516e876d39da5 --- /dev/null +++ b/675/TumorCenter_CD8_block12_x6_y11_patient675_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20639.1, + "Centroid Y µm": 37055.4, + "Num Detections": 13308, + "Num Negative": 12750, + "Num Positive": 558, + "Positive %": 4.193, + "Num Positive per mm^2": 321.08 + } +} \ No newline at end of file diff --git a/675/history_text.txt b/675/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..aeb01169531148d2fceb31bc865fb1338284c35a --- /dev/null +++ b/675/history_text.txt @@ -0,0 +1 @@ +After panendoscopy and CT, the patient presents with a cT4a laryngeal/hypopharyngeal carcinoma on the left side. \ No newline at end of file diff --git a/675/icd_codes.txt b/675/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45d2eca409f9787902f5bba4aeda97ed19776348 --- /dev/null +++ b/675/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] \ No newline at end of file diff --git a/675/ops_codes.txt b/675/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d21d19ed126c2ae1df69ffb2b2966b3ab2976169 --- /dev/null +++ b/675/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Reoperation[5-983 ] Laryngektomie mit Pharyngektomie und Schilddrüsenresektion mit Rekonstruktion mit lokaler Schleimhaut[5-303.21 ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/675/patient_clinical_data.json b/675/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..50ebcd4e7c5701981b32c0e9faac42ce327490de --- /dev/null +++ b/675/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/675/patient_pathological_data.json b/675/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..629cd78645355f363977c1d96598da6440d080aa --- /dev/null +++ b/675/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "675", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 44, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/675/surgery_description.txt b/675/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..85badb1c8ba6db652827a259a65211423d8565ce --- /dev/null +++ b/675/surgery_description.txt @@ -0,0 +1 @@ +LE diff --git a/675/surgery_report.txt b/675/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1007eea42754d36dc103e874517f693ed1bff403 --- /dev/null +++ b/675/surgery_report.txt @@ -0,0 +1 @@ +First deepening of the anesthesia, bronchoscopic intubation (very difficult) through the anesthesia. Nasotracheal intubation is finally successful. Head positioning, insertion of the mouth guard. Insertion of the size C and D small bore tube. The tumor begins in the lower part of the oropharynx on the left, then moves caudally along the hypopharyngeal side wall, leaving out the esophageal mouth, but does not reach the midline of the hypopharynx. However, the vallecula is included, but does not extend to the midline. The epiglottis is also affected on the laryngeal side. After inspection, repositioning, skin disinfection and infiltration anesthesia with 15 ml Ultracaine with added adrenaline cervically on both sides. Then skin disinfection. After head positioning, formation of an apron flap. Preparation subplatysmal. Release of the submandibular glands on both sides. Protection of the infrahyoid musculature. Start with neck dissection on the left side: a cN2b status is seen here, infiltration in the sternocleidomastoid muscle and the internal jugular vein. First dissection along the muscle, which is then cut caudally and the internal jugular vein and the common carotid artery as well as the vagus nerve are identified on the vascular nerve cord. Dissection cranially. Then first release the medial neck preparation ventrally. Dissection of the infrahyoid musculature up to the digastric muscle cranially, then from the muscle belly dissection dorsally. Definition of the posterior border. Then consecutive release of the metastasis-neck preparation from medial to lateral. Ligation and ligation of the macroscopically visible infiltration of the internal jugular vein. Protection of the internal, common and external carotid arteries and the vagus nerve. Once the hypoglossal nerve has been identified, it is also safely mobilized from the tumour conglomerate under macroscopic vision in healthy tissue and dissected. Removal of the entire tumor preparation and removal of most parts of the cervical plexus and the accessorius nerve. After careful hemostasis, placement of a Redon drain. Now transfer to the right side: first mobilize the sternocleidomastoid muscle here as well. No macroscopically conspicuous lymph nodes here. Then develop the lateral neck preparation from caudal to cranial. Identification, visualization and protection of the accessorius nerve. Evacuation of the accessorius triangle and levels II, III, IV and V. In the end, no evidence of lymph flow or bleeding. Skeletonization of the laryngeal skeleton between the upper edge of the thyroid cartilage and the hyoid. Incision on the edge of the thyroid cartilage. Dissection and mobilization of the constrictor and hypopharyngeal mucosa ventrally. Entering the lumen in the area of the base of the tongue. Inspection with an overview of the tumor. The tumor is now removed macroscopically under visualization, the larynx is then developed consecutively from cranial to caudal under visualization. The entire tumor preparation is then suture-marked and sent for frozen section diagnostics, which also revealed tumor extensions in the area of the right-sided margin. At this point, a resection was also sent, but it was tumor-free, so that after taking a new strip until the final histology, it can be assumed that an in sano resection margin of 1.0 to 1.5 cm was maintained. After hemostasis, the tracheotomy was performed: fixation with 2 holding sutures. Then, after myotomy of the cricopharyngeus, placement of a Provox 2 prosthesis in the usual manner and beginning with the single-button suture of the pharyngeal mucosa, which is guided inverted from caudal to cranial. In the tongue base area, T-shaped adaptation of the tongue base resection margin with the mucosa of the pharynx. Two-layer wound closure possible here without tension. Intraoperative demonstration of findings on . Mobilization of the infrahyoid musculature, which is now mobilized cranially, which is very successful and is stitched together with the thyroid gland as a stable muscle cuff over the pharyngeal suture, so that the entire suture area can be covered in the neopharyngeal region. Suturing of the tracheostoma with Ethibond sutures, two-layer wound closure after ensuring the correct position of the Redon drainage on both sides and application of a sterile dressing. Stable ventilation conditions under the inserted 10 mm tracheostomy tube. The patient received perioperative antibiotics with clindamycin 600 mg, which should be continued perioperatively. Due to the parabasal position of a peripheral venous catheter in the left arm, this should be monitored in the further postoperative course. Blood-free conditions at the end of the procedure. Removal of the gastric tube after swallowing gruel on postoperative day 7. A gastric tube was not placed with the PEG tube in place. \ No newline at end of file diff --git a/676/InvasionFront_CD3_block13_x3_y9_patient676_0.json b/676/InvasionFront_CD3_block13_x3_y9_patient676_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4313d65b7704e56e1da6b80936cfecb36fe072ed --- /dev/null +++ b/676/InvasionFront_CD3_block13_x3_y9_patient676_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 21688.5, + "Num Detections": 22700, + "Num Negative": 19487, + "Num Positive": 3213, + "Positive %": 14.15, + "Num Positive per mm^2": 1259.4 + } +} \ No newline at end of file diff --git a/676/InvasionFront_CD3_block13_x4_y9_patient676_1.json b/676/InvasionFront_CD3_block13_x4_y9_patient676_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6f448b0d7dc5b995f0d74fd2abe542a591ac694a --- /dev/null +++ b/676/InvasionFront_CD3_block13_x4_y9_patient676_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 21613.6, + "Num Detections": 19948, + "Num Negative": 17183, + "Num Positive": 2765, + "Positive %": 13.86, + "Num Positive per mm^2": 1182.0 + } +} \ No newline at end of file diff --git a/676/InvasionFront_CD8_block13_x3_y9_patient676_0.json b/676/InvasionFront_CD8_block13_x3_y9_patient676_0.json new file mode 100644 index 0000000000000000000000000000000000000000..70ae7dd68602c2fda2470d758867c970f9396dfc --- /dev/null +++ b/676/InvasionFront_CD8_block13_x3_y9_patient676_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11618.8, + "Centroid Y µm": 23387.6, + "Num Detections": 25455, + "Num Negative": 24978, + "Num Positive": 477, + "Positive %": 1.874, + "Num Positive per mm^2": 180.72 + } +} \ No newline at end of file diff --git a/676/InvasionFront_CD8_block13_x4_y9_patient676_1.json b/676/InvasionFront_CD8_block13_x4_y9_patient676_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1cb3b3435f374e481337c4622e52b0f2251d39d3 --- /dev/null +++ b/676/InvasionFront_CD8_block13_x4_y9_patient676_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14317.4, + "Centroid Y µm": 23462.6, + "Num Detections": 22301, + "Num Negative": 21664, + "Num Positive": 637, + "Positive %": 2.856, + "Num Positive per mm^2": 258.3 + } +} \ No newline at end of file diff --git a/676/TumorCenter_CD3_block13_x3_y9_patient676_0.json b/676/TumorCenter_CD3_block13_x3_y9_patient676_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2e4b3d947d956d70508e647954e75e991a05fc74 --- /dev/null +++ b/676/TumorCenter_CD3_block13_x3_y9_patient676_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 28784.8, + "Num Detections": 19144, + "Num Negative": 18770, + "Num Positive": 374, + "Positive %": 1.954, + "Num Positive per mm^2": 167.9 + } +} \ No newline at end of file diff --git a/676/TumorCenter_CD3_block13_x4_y9_patient676_1.json b/676/TumorCenter_CD3_block13_x4_y9_patient676_1.json new file mode 100644 index 0000000000000000000000000000000000000000..302641a41569d62b2a40004abb45a25175f2cc3c --- /dev/null +++ b/676/TumorCenter_CD3_block13_x4_y9_patient676_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 29009.6, + "Num Detections": 20805, + "Num Negative": 20003, + "Num Positive": 802, + "Positive %": 3.855, + "Num Positive per mm^2": 314.55 + } +} \ No newline at end of file diff --git a/676/TumorCenter_CD8_block13_x3_y9_patient676_0.json b/676/TumorCenter_CD8_block13_x3_y9_patient676_0.json new file mode 100644 index 0000000000000000000000000000000000000000..afe5244c014f0d4cfb69272292b50fa06593c906 --- /dev/null +++ b/676/TumorCenter_CD8_block13_x3_y9_patient676_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12693.3, + "Centroid Y µm": 22363.2, + "Num Detections": 17986, + "Num Negative": 17949, + "Num Positive": 37, + "Positive %": 0.2057, + "Num Positive per mm^2": 17.51 + } +} \ No newline at end of file diff --git a/676/TumorCenter_CD8_block13_x4_y9_patient676_1.json b/676/TumorCenter_CD8_block13_x4_y9_patient676_1.json new file mode 100644 index 0000000000000000000000000000000000000000..22118804b0671a5aa8fefe83e6b4ee4ad9aabf46 --- /dev/null +++ b/676/TumorCenter_CD8_block13_x4_y9_patient676_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15216.9, + "Centroid Y µm": 22013.3, + "Num Detections": 19287, + "Num Negative": 19250, + "Num Positive": 37, + "Positive %": 0.1918, + "Num Positive per mm^2": 15.21 + } +} \ No newline at end of file diff --git a/676/history_text.txt b/676/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..dad859a860ae7241ce30859f2c2cc521fa30630f --- /dev/null +++ b/676/history_text.txt @@ -0,0 +1 @@ +During preoperative diagnostics, the patient was found to have a histologically confirmed oral cavity carcinoma in the area of the underside of the right anterior third of the tongue. There is now an indication for transoral tumor resection. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/676/icd_codes.txt b/676/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8235f69822bdef09bcebc898840583a0443e6bb6 --- /dev/null +++ b/676/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Zungenunterfläche[C02.2 R] \ No newline at end of file diff --git a/676/ops_codes.txt b/676/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c13ecb77c1b7c9f56c9c739f0956a45da68aef94 --- /dev/null +++ b/676/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Partielle Exzision Mundboden[5-273.6 ] \ No newline at end of file diff --git a/676/patient_clinical_data.json b/676/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c6d3786e1884b617027cd5bb2c17d6ac49713842 --- /dev/null +++ b/676/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 71, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 1, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/676/patient_pathological_data.json b/676/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bb1974766745aaef6b776c945adcae213b6cfb73 --- /dev/null +++ b/676/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "676", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/676/surgery_description.txt b/676/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..75c9bf7f758ab6a630ef73c278517ca376c365a3 --- /dev/null +++ b/676/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy diff --git a/676/surgery_report.txt b/676/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..9b64aa6be774ab073d69b5a17c877ca7251aa72d --- /dev/null +++ b/676/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia and transition to rigid tracheoscopy. Setting up the glottis without irritation and passing it with the 0° optics. Entry after endotracheal. Mucosal conditions are unremarkable on all sides up to the exit of the segmental bronchi. The patient is then intubated nasotracheally by the anesthetist. Transition to esophagogastroscopy. Insertion of the endoscope under visualization and constant air insufflation into the stomach. There is no evidence of a synchronous second tumor. Inversion and inspection of the gastroesophageal junction. This appears unremarkable. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. With the exception of small glycogen acanthoses, there is no evidence of malignancy here either. Removal of the endoscope. Insertion of the mouth guard. Insertion with the size C small bore tube. First, adjust the endolarynx. This appears inconspicuous. Subsequently, meticulous inspection of the hypopharynx on both sides. The piriform sinus is lined on both sides by smooth mucosa on all sides and can be freely unfolded up to the tip. Postcricoid as well as in the area of the esophageal entrance are also unremarkable on all sides. Subsequently, inspection and palpation of the base of the tongue. This is also unremarkable. Inspection of the oral cavity. First insertion of the spandex cheek and lip expander. Insertion of the reinforced mouth guard. Applying the tongue suture. An exophytic tumor measuring approx. 1.5 x 1.5 cm can be seen in the area of the anterior third of the tongue on the right, on the underside. In addition, in the dorsal third of the tongue, just before the glossotonsillar groove on the underside of the tongue, there is a further primary suspicious change in the mucosa. Even after meticulous inspection, this does not appear to be in contact with the first mass. A synchronous second tumor must therefore be assumed. The planned resection margins are now marked. Start with the exophytic tumor in the area of the ventral underside of the tongue. Successive resection of the tumor while maintaining the necessary resection margins using the ultrasound-activated scalpel. The specimen is thread-marked for frozen section diagnostics. Hemostasis using bipolar coagulation. Subsequently, the second high-suspect area in the area of the dorsal third of the tongue is also incised on the underside and passes over to the dorsal floor of the mouth. Here too, an invasive procedure must be assumed, which is why meticulous attention is paid to maintaining the necessary safety distances. The second specimen is also thread-marked for frozen section diagnostics. Both invasive carcinomas were resected in sano during the frozen section diagnosis by telephone. Only in the area of the dorsally located second carcinoma are there still extensions of a carcinoma in situ at the molar and anterior margin. A resection and corresponding margin samples are now taken. Hemostasis by means of bipolar coagulation. Finally, instillation of a cumulative 7 ml of ropivacaine for postoperative analgesia. Loosening of the suture. Removal of the spandex and the reinforced mouth guard. Final consultation with the anesthetist. Completion of the operation without complications. \ No newline at end of file diff --git a/677/InvasionFront_CD3_block20_x5_y8_patient677_0.json b/677/InvasionFront_CD3_block20_x5_y8_patient677_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d1341262204820557c5867da0ac54f8b78f179a3 --- /dev/null +++ b/677/InvasionFront_CD3_block20_x5_y8_patient677_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16841.1, + "Centroid Y µm": 20289.3, + "Num Detections": 16031, + "Num Negative": 15507, + "Num Positive": 524, + "Positive %": 3.269, + "Num Positive per mm^2": 267.42 + } +} \ No newline at end of file diff --git a/677/InvasionFront_CD3_block20_x6_y8_patient677_1.json b/677/InvasionFront_CD3_block20_x6_y8_patient677_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ef66e732ab8f8792389e43152124515d50665a7 --- /dev/null +++ b/677/InvasionFront_CD3_block20_x6_y8_patient677_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19364.7, + "Centroid Y µm": 20614.1, + "Num Detections": 15509, + "Num Negative": 15243, + "Num Positive": 266, + "Positive %": 1.715, + "Num Positive per mm^2": 138.01 + } +} \ No newline at end of file diff --git a/677/InvasionFront_CD8_block20_x5_y8_patient677_0.json b/677/InvasionFront_CD8_block20_x5_y8_patient677_0.json new file mode 100644 index 0000000000000000000000000000000000000000..568ed30418a0d17aef8d7da76fbf744fa36f5b76 --- /dev/null +++ b/677/InvasionFront_CD8_block20_x5_y8_patient677_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17153.4, + "Centroid Y µm": 19939.4, + "Num Detections": 10817, + "Num Negative": 10622, + "Num Positive": 195, + "Positive %": 1.803, + "Num Positive per mm^2": 149.75 + } +} \ No newline at end of file diff --git a/677/InvasionFront_CD8_block20_x6_y8_patient677_1.json b/677/InvasionFront_CD8_block20_x6_y8_patient677_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4ab8d8f46775eee48bdee021d635e2932b0a6a89 --- /dev/null +++ b/677/InvasionFront_CD8_block20_x6_y8_patient677_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19702.1, + "Centroid Y µm": 19926.9, + "Num Detections": 15399, + "Num Negative": 15233, + "Num Positive": 166, + "Positive %": 1.078, + "Num Positive per mm^2": 88.35 + } +} \ No newline at end of file diff --git a/677/TumorCenter_CD3_block20_x5_y8_patient677_0.json b/677/TumorCenter_CD3_block20_x5_y8_patient677_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4be61d59ae72cd5d77734b6af3e89711dd9829bd --- /dev/null +++ b/677/TumorCenter_CD3_block20_x5_y8_patient677_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16226.2, + "Centroid Y µm": 19114.7, + "Num Detections": 11771, + "Num Negative": 11634, + "Num Positive": 137, + "Positive %": 1.164, + "Num Positive per mm^2": 82.85 + } +} \ No newline at end of file diff --git a/677/TumorCenter_CD3_block20_x6_y8_patient677_1.json b/677/TumorCenter_CD3_block20_x6_y8_patient677_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ea543a68b2d33b4f8de433a55e2dce9e43059220 --- /dev/null +++ b/677/TumorCenter_CD3_block20_x6_y8_patient677_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18838.3, + "Centroid Y µm": 19235.0, + "Num Detections": 17090, + "Num Negative": 16611, + "Num Positive": 479, + "Positive %": 2.803, + "Num Positive per mm^2": 248.98 + } +} \ No newline at end of file diff --git a/677/TumorCenter_CD8_block20_x5_y8_patient677_0.json b/677/TumorCenter_CD8_block20_x5_y8_patient677_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d7e59c063faba1a62f063c6c56bd21200d3fa78 --- /dev/null +++ b/677/TumorCenter_CD8_block20_x5_y8_patient677_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16515.7, + "Centroid Y µm": 20177.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/677/TumorCenter_CD8_block20_x6_y8_patient677_1.json b/677/TumorCenter_CD8_block20_x6_y8_patient677_1.json new file mode 100644 index 0000000000000000000000000000000000000000..14dfc7ba4accc1fbef8c62ac2d7269b734cd044b --- /dev/null +++ b/677/TumorCenter_CD8_block20_x6_y8_patient677_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 19714.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/677/history_text.txt b/677/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7b81566b37f79ff3884515576985d6690ee2b690 --- /dev/null +++ b/677/history_text.txt @@ -0,0 +1 @@ +The patient had a pT2 pN0 tonsillar carcinoma in 1994 with adjuvant radiotherapy up to 60 Gy. The patient has now developed a second carcinoma in the supraglottis area on the left pocket fold with ingrowth into the thyroid cartilage. Prior consultation with that neck dissection would not be performed in the case of a cN0 neck status and condition after neck dissection on both sides. \ No newline at end of file diff --git a/677/icd_codes.txt b/677/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4b2b94cb50933cfa2488a2941aa728866a25f7e3 --- /dev/null +++ b/677/icd_codes.txt @@ -0,0 +1 @@ +Supraglottisches Karzinom[C32.1 ] \ No newline at end of file diff --git a/677/ops_codes.txt b/677/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..79e563c73636d9b07dc0286f4cb3a26cb1d78694 --- /dev/null +++ b/677/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/677/patient_clinical_data.json b/677/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3f0896580e0a8e9a58ac90402fc4ef57896f4783 --- /dev/null +++ b/677/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 69, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/677/patient_pathological_data.json b/677/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2b67be8c77b35a962ab2965544be68266bbe344a --- /dev/null +++ b/677/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "677", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 1, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 21.0 +} \ No newline at end of file diff --git a/677/surgery_description.txt b/677/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a6a5f2d906b5d194c0fb19c4cf79c80b8f73e7e --- /dev/null +++ b/677/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, PEG tube diff --git a/677/surgery_report.txt b/677/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc0ef625f07c0f0ef703c03a21331d87cf8ebee3 --- /dev/null +++ b/677/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesiologist, entry with the Kleinsasser tube. Inspection of the hypopharynx and larynx. The tumor described above can be seen in the area of the left pocket fold, moving forward into the anterior commissure and also infiltrating the vocal fold on the left. The piriform sinus, epiglottis and vallecula are tumor-free. A PEG tube is then inserted in the usual way. This can be done without any problems via the old PEG insertion site. Then mark the skin incision and make the incision median to the neck. The laryngeal skeleton can now be prepared directly. The larynx is skeletonized. Exposure of the hyoid bone. Skeletonization of the hyoid bone and removal of the hyoid bone. Then release of the thyroid gland on both sides. Separation of the oblique laryngeal muscles. Dissection of the cervical vascular sheath from the larynx. Exposure of the trachea. Release of the upper thyroid cartilage horn, initially on the right side. Then incision of the periosteum on the thyroid cartilage and removal of the piriform sinus. The same is done on the opposite side. Unfortunately, it cannot be done this far, as the tumor is located on this side. Then expose the pharynx, directly below the base of the tongue at the level of the epiglottis. Pull out the epiglottis and cut around the epiglottis, first on the right side, then on the left side. Release the larynx also in the postcricoid region. Then perform the tracheotomy below the cricoid cartilage and reintubation. Deposition of the laryngeal preparation below the cricoid cartilage. It can be seen that the tumor is relatively close to the resection margin on the lateral pharyngeal wall in the transition to the piriform sinus. To be on the safe side, a large resection is taken and a frozen section is also made of the site, which is ultimately classified by the pathologist as carcinoma in situ and tumor-free. The specimen is sent to the pathologist marked with a thread. Now start with the pharyngeal suture. First at the base of the tongue, then from caudal to cranial, so that the sutures virtually meet in the middle of the pharyngeal defect. Single button sutures are made. Then second single button suture in the usual manner and third pharyngeal suture by beating the thyroid gland and the remaining muscles over it. Insertion of two Redon drains and formation of a tracheostoma through a mucocutaneous anastomosis. Before the pharyngeal suture, a Provox prosthesis was of course inserted in the usual manner, size 8, with the trocar approx. 1 cm below the stoma. Two-layer wound closure. The operation was completed without complications. Please continue antibiotic treatment and X-ray swallow on the 10th postoperative day. If a fistula is suspected, please open the neck. \ No newline at end of file diff --git a/678/InvasionFront_CD3_block5_x5_y6_patient678_0.json b/678/InvasionFront_CD3_block5_x5_y6_patient678_0.json new file mode 100644 index 0000000000000000000000000000000000000000..406542cf3f3175bb430db5560ddc1d89d1ee639f --- /dev/null +++ b/678/InvasionFront_CD3_block5_x5_y6_patient678_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 15491.8, + "Num Detections": 21059, + "Num Negative": 20285, + "Num Positive": 774, + "Positive %": 3.675, + "Num Positive per mm^2": 308.02 + } +} \ No newline at end of file diff --git a/678/InvasionFront_CD3_block5_x6_y6_patient678_1.json b/678/InvasionFront_CD3_block5_x6_y6_patient678_1.json new file mode 100644 index 0000000000000000000000000000000000000000..892a69af13eb3ababc6ab43e348b92445184cd7f --- /dev/null +++ b/678/InvasionFront_CD3_block5_x6_y6_patient678_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19039.9, + "Centroid Y µm": 15666.7, + "Num Detections": 23517, + "Num Negative": 23010, + "Num Positive": 507, + "Positive %": 2.156, + "Num Positive per mm^2": 192.51 + } +} \ No newline at end of file diff --git a/678/InvasionFront_CD8_block5_x5_y5_patient678_0.json b/678/InvasionFront_CD8_block5_x5_y5_patient678_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e2a14d152dbd87672a95c3081722b081f618616a --- /dev/null +++ b/678/InvasionFront_CD8_block5_x5_y5_patient678_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 12768.2, + "Num Detections": 10207, + "Num Negative": 9418, + "Num Positive": 789, + "Positive %": 7.73, + "Num Positive per mm^2": 652.91 + } +} \ No newline at end of file diff --git a/678/InvasionFront_CD8_block5_x6_y5_patient678_1.json b/678/InvasionFront_CD8_block5_x6_y5_patient678_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0663dec6304185e04aa7191aaa54a846e29cfc5f --- /dev/null +++ b/678/InvasionFront_CD8_block5_x6_y5_patient678_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 13068.1, + "Num Detections": 17352, + "Num Negative": 16902, + "Num Positive": 450, + "Positive %": 2.593, + "Num Positive per mm^2": 235.24 + } +} \ No newline at end of file diff --git a/678/TumorCenter_CD3_block5_x5_y5_patient678_0.json b/678/TumorCenter_CD3_block5_x5_y5_patient678_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4b0bc0d1c4ae99890e5bb6f798876d390c206462 --- /dev/null +++ b/678/TumorCenter_CD3_block5_x5_y5_patient678_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 12918.2, + "Num Detections": 11741, + "Num Negative": 10056, + "Num Positive": 1685, + "Positive %": 14.35, + "Num Positive per mm^2": 1489.7 + } +} \ No newline at end of file diff --git a/678/TumorCenter_CD3_block5_x6_y5_patient678_1.json b/678/TumorCenter_CD3_block5_x6_y5_patient678_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b0fe887d2ec7a2de682c84ede86d89e48931f122 --- /dev/null +++ b/678/TumorCenter_CD3_block5_x6_y5_patient678_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19964.4, + "Centroid Y µm": 13068.1, + "Num Detections": 9903, + "Num Negative": 9484, + "Num Positive": 419, + "Positive %": 4.231, + "Num Positive per mm^2": 393.29 + } +} \ No newline at end of file diff --git a/678/TumorCenter_CD8_block5_x5_y5_patient678_0.json b/678/TumorCenter_CD8_block5_x5_y5_patient678_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e76368dce5edf1e376d595ccea22582081719375 --- /dev/null +++ b/678/TumorCenter_CD8_block5_x5_y5_patient678_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16203.9, + "Centroid Y µm": 12655.8, + "Num Detections": 11291, + "Num Negative": 9050, + "Num Positive": 2241, + "Positive %": 19.85, + "Num Positive per mm^2": 1954.7 + } +} \ No newline at end of file diff --git a/678/TumorCenter_CD8_block5_x6_y5_patient678_1.json b/678/TumorCenter_CD8_block5_x6_y5_patient678_1.json new file mode 100644 index 0000000000000000000000000000000000000000..61a464791ba2e1db65ac0389399e6757ddcce27f --- /dev/null +++ b/678/TumorCenter_CD8_block5_x6_y5_patient678_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18802.5, + "Centroid Y µm": 12705.8, + "Num Detections": 10514, + "Num Negative": 10222, + "Num Positive": 292, + "Positive %": 2.777, + "Num Positive per mm^2": 280.22 + } +} \ No newline at end of file diff --git a/678/history_text.txt b/678/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..69fae621889fd75d6156a91d760172522f06fe28 --- /dev/null +++ b/678/history_text.txt @@ -0,0 +1 @@ +Patient with suspected cervical CUP syndrome. After a primarily unremarkable panendoscopy and no evidence of a primary tumor in the previously performed PET-CT, there is now an indication for CUP panendoscopy including neck dissection on the right side and PEG placement. The patient had ample opportunity to ask questions about the procedure during several detailed preoperative discussions. \ No newline at end of file diff --git a/678/icd_codes.txt b/678/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b1c8c175eb0a5054ec2dfcca218df0a276a8a42a --- /dev/null +++ b/678/icd_codes.txt @@ -0,0 +1 @@ +CUP [Cancer of Unknown Primary][C80.0 R] \ No newline at end of file diff --git a/678/ops_codes.txt b/678/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..089184beb290d14e4a9b31c3c29d8fd26a2cb2f2 --- /dev/null +++ b/678/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Primäreingriff Adenotomie[5-285.0 ] Tonsillektomie mit Dissektionstechnik[5-281.0 ] Biopsie an der Zunge ohne Inzision[1-420.1 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 6 Regionen[5-403.22 R] \ No newline at end of file diff --git a/678/patient_clinical_data.json b/678/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fb8f1c2eacf1c27f87318de847df2f614cad69ec --- /dev/null +++ b/678/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 48, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/678/patient_pathological_data.json b/678/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..27a95caa7a77108648cbb8eac107f2c8fc4f978c --- /dev/null +++ b/678/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "678", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 5.0, + "number_of_resected_lymph_nodes": 36, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/678/surgery_description.txt b/678/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a9ae08cc8dae4a91af726c0d6e94fcce2680cc79 --- /dev/null +++ b/678/surgery_description.txt @@ -0,0 +1 @@ +CUP Panendoscopy, Neck dissection on the right (Level I-V), Tonsillectomy; PEG placement diff --git a/678/surgery_report.txt b/678/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0893791eabffb05932bd3c5b4d1e1ca341e9de26 --- /dev/null +++ b/678/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with the anesthesia department. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. Transition to PEG insertion. First insertion of the endoscope under visualization and constant air insufflation into the stomach. If the diaphanoscopy is clear, the PEG tube is now placed using the thread pull-through method in the typical manner. Fix the tube in place and apply a wound dressing. Transition to CUP panendoscopy. First position the patient in head reclination. Insert the McIvor oral spatula while protecting the teeth, lips and tongue. Apply the velotractio in the typical manner. Insertion of the Beckmann's ring knife and removal of a flat sample from the epipharyngeal region. In addition, selective removal of smaller samples from the area of Rosenmüller's fossa on both sides. Hemostasis by insertion of an H2O2-soaked ball swab and bipolar coagulation. If the wound bed is dry, the velotractio is removed. Transition to tonsillectomy. Start on the right side. The tonsils appear extremely atrophic. First grasp the upper pole and dislodge the tonsil from the bed. Incision of the mucosa close to the uvula and exposure of the tonsil capsule. Successive dissection along the capsule while protecting the anterior and posterior palatal arch. Exposure of the lower tonsil pole. Bipolar coagulation of the lower pole vessels. Removing the tonsil at the lower pole and performing a mucosal plasty in the direction of the base of the tongue. Insertion of an H2O2-soaked ball swab. Transition to the left side. In principle the same procedure as on the right. Here too, a mucosoplasty is performed on the caudal tonsil pole in the direction of the base of the tongue. Intraoperatively, there was no evidence of malignancy on either the right or the left side. Removal of the McIvor oral spatula. Insertion of the mouth guard. Insertion with the size C small bore tube. First set the base of the tongue in the median line. Take several representative samples from the base of the tongue median and paramedian left and right. The samples are sent separately for histological processing. Hemostasis using monopolar coagulation. Final inspection of the tonsil lobe on both sides. Occasional bipolar coagulation of minor bleeding in the area of the lateral tonsil bed on both sides. If the wound bed is dry, the patient is repositioned for neck dissection. First, skin spray disinfection and infiltration anesthesia. Abjode the surgical site and cover it sterilely. Marking of the mandibular arch and the ascending mandibular branch. Marking of the planned incision. Sharp cutting of the cutis and subcutis. Expose the anterior edge of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Overall, there is pronounced metastasis, especially in levels II and III. The posterior digastric venter muscle cannot be visualized initially due to the extensive metastatic conglomerate. Therefore turn to visualization of the cervical vascular sheath. Dissection of the internal jugular vein, the venous angle and the common carotid artery, the bifurcation and the internal/external carotid artery. Exposure of the accessorius nerve and successive detachment of the metastatic conglomerate from the digastric muscle. Relocation and, at the end of the operation, re-embedding of the accessorius nerve in the sense of neurolysis. In level II b, the metastases extend far to the cranial side. Successive development of the lateral neck preparation while sparing the accessory nerve and the plexus branches. Clearing of levels II b, II a, III, IV as well as V. Level IV also shows a clearly enlarged lymph node, which however could also be reactively altered by the previous operation. Then turn to the medial neck preparation. Successive detachment of a large metastasis located in the venous angle. Exposure of the hypoglossal nerve and protection of the same. Displacement and, at the end of the operation, re-embedding of the hypoglossal nerve in the sense of neurolysis. Here too, the metastasis extends far to the cranial side. However, the oral branch can be stimulated in depth with the help of stimulation. Ultimately, the medial neck preparation can also be completely developed. At the end of the operation, the wound was dry on all sides. Levels I b, II a, II b, III, IV and V were evacuated. The wound cavity was rinsed with H2O2 and Ringer's solution. Insertion of a 10 Redon drain. Subcutaneous suturing with Vicryl 4.0 and skin suturing with Ethilon 5.0. Application of a wound and pressure dressing. Completion of the operation without complications. Final consultation with the anesthesiologist. The patient received 3 g Unacid intraoperatively as a single shot antibiotic. Conclusion: CUP panendoscopy and right neck dissection in 5 regions. Overall extensive right cervical metastasis. Further procedure after receipt of the definitive histology. \ No newline at end of file diff --git a/679/InvasionFront_CD8_block6_x1_y12_patient679_0.json b/679/InvasionFront_CD8_block6_x1_y12_patient679_0.json new file mode 100644 index 0000000000000000000000000000000000000000..16246bfb0569098604e2f05dcbc88623d33478a3 --- /dev/null +++ b/679/InvasionFront_CD8_block6_x1_y12_patient679_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 29934.2, + "Num Detections": 26465, + "Num Negative": 16244, + "Num Positive": 10221, + "Positive %": 38.62, + "Num Positive per mm^2": 3681.6 + } +} \ No newline at end of file diff --git a/679/InvasionFront_CD8_block6_x2_y12_patient679_1.json b/679/InvasionFront_CD8_block6_x2_y12_patient679_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aa592c876014de4c6ef8b0b9832b44420fb64abd --- /dev/null +++ b/679/InvasionFront_CD8_block6_x2_y12_patient679_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6471.6, + "Centroid Y µm": 30009.1, + "Num Detections": 26802, + "Num Negative": 18991, + "Num Positive": 7811, + "Positive %": 29.14, + "Num Positive per mm^2": 2988.9 + } +} \ No newline at end of file diff --git a/679/TumorCenter_CD3_block6_x1_y12_patient679_0.json b/679/TumorCenter_CD3_block6_x1_y12_patient679_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ae74c00d5d8e59bd077db4fe28a0d6ec688c0e97 --- /dev/null +++ b/679/TumorCenter_CD3_block6_x1_y12_patient679_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4247.8, + "Centroid Y µm": 30508.8, + "Num Detections": 25891, + "Num Negative": 11188, + "Num Positive": 14703, + "Positive %": 56.79, + "Num Positive per mm^2": 5060.1 + } +} \ No newline at end of file diff --git a/679/TumorCenter_CD3_block6_x2_y12_patient679_1.json b/679/TumorCenter_CD3_block6_x2_y12_patient679_1.json new file mode 100644 index 0000000000000000000000000000000000000000..047c05d6f6bd7ef363ca7f8e1695a8e0af7553c1 --- /dev/null +++ b/679/TumorCenter_CD3_block6_x2_y12_patient679_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 30508.8, + "Num Detections": 23546, + "Num Negative": 11077, + "Num Positive": 12469, + "Positive %": 52.96, + "Num Positive per mm^2": 4709.5 + } +} \ No newline at end of file diff --git a/679/TumorCenter_CD8_block6_x1_y12_patient679_0.json b/679/TumorCenter_CD8_block6_x1_y12_patient679_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e63989057da3a1b551d1c78d6840573834151bfa --- /dev/null +++ b/679/TumorCenter_CD8_block6_x1_y12_patient679_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 30933.6, + "Num Detections": 26666, + "Num Negative": 15070, + "Num Positive": 11596, + "Positive %": 43.49, + "Num Positive per mm^2": 3990.7 + } +} \ No newline at end of file diff --git a/679/TumorCenter_CD8_block6_x2_y12_patient679_1.json b/679/TumorCenter_CD8_block6_x2_y12_patient679_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9304ecbfaf2a694791bce29e35feedec73e975b3 --- /dev/null +++ b/679/TumorCenter_CD8_block6_x2_y12_patient679_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 30933.6, + "Num Detections": 24176, + "Num Negative": 13535, + "Num Positive": 10641, + "Positive %": 44.01, + "Num Positive per mm^2": 3999.7 + } +} \ No newline at end of file diff --git a/679/history_text.txt b/679/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b9dbce0acf480395d1acae32bb09d421862b3d7b --- /dev/null +++ b/679/history_text.txt @@ -0,0 +1 @@ +The patient had a lymph node metastasis of a basaloid carcinoma in level II on the left side confirmed by a gross needle punch. The PET-CT showed increased FTG storage in the area of the left tonsil, so a panendoscopy with left tonsillectomy and, if necessary, CUP panendoscopy was indicated. A detailed preoperative discussion was held with the patient and his about the planned procedure and there was ample opportunity to ask questions. \ No newline at end of file diff --git a/679/icd_codes.txt b/679/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa6097eacf18ae8aea8260bca82cce6b0a31ad0c --- /dev/null +++ b/679/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 L] \ No newline at end of file diff --git a/679/ops_codes.txt b/679/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..679a64e27c9c1cd0fb80ea3cc9beebe50c982430 --- /dev/null +++ b/679/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Tracheobronchoskopie[1-620.x ] Endoskopische Biopsie am Ösophagus[1-440.a ] Transorale Tumortonsillektomie[5-281.2 ] Biopsie am Nasopharynx durch Inzision[1-548 ] Biopsie an der Zunge ohne Inzision[1-420.1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/679/patient_clinical_data.json b/679/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c6f57f32114f92177d5517eaa274fa7fd00446b6 --- /dev/null +++ b/679/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 49, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 27, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/679/patient_pathological_data.json b/679/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..825f5aad767cbf39dbd2b9b5a4f8651a1a6eb5a8 --- /dev/null +++ b/679/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "679", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/679/surgery_description.txt b/679/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ee246dc6b41f7c68514e1c8955e48a768b18963f --- /dev/null +++ b/679/surgery_description.txt @@ -0,0 +1 @@ +Tumor-tonsillectomy, Panendoscopy, PE's diff --git a/679/surgery_report.txt b/679/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..afca1ef9e48b1271db6270091078b14e36de29be --- /dev/null +++ b/679/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia by the anesthesia colleagues. Then rigid tracheoscopy with the O° scope by the surgeon. The trachea is free and non-irritated up to the carina with inconspicuous mucosa. Intubation by the anesthesia colleagues and then insertion of the Mc Ivor mouth blocker. Palpation of the tonsilloliths on both sides. Small palatine tonsils can be seen on both sides, with the left tonsil in the upper pole being slightly indurated in comparison to the sides. Demonstration of the findings to and determination of the procedure. Tonsillectomy on the left should be performed first, followed by a frozen section. Subsequently, panendoscopy and nasopharyngeal curettage and removal of tongue base biopsies with clinically largely unremarkable left tonsil. Approach for left tonsillectomy: Exposure of the upper pole of the tonsil. The tonsil is successively and completely removed with bipolar and scissors. The posterior palatal arch is left completely intact. Laterally, the tonsil is released quite generously and caudally it is separated with the bipolar and scissors. The suture markings are made cranially and laterally. At the transition to the base of the tongue in the glossotonsillar groove, individual lymph follicles are still visible, which cannot be clearly assigned to the tonsil; these are resected separately with bipolar and scissors and submitted as histology glossotonsillar groove for frozen section assessment. There is no relevant bleeding after the tonsillectomy. Removal of the oral retractor and insertion of the flexible esophagogastroscope into the stomach in the typical manner. The gastric mucosa is completely free of irritation up to the pylorus and with inversion in the area of the cardia. Then carefully withdraw the esophagoscope with constant air insufflation. From 40 to 43 cm tooth row there are isolated erosions and at 42 cm from the tooth row a spherical exophytic, but overall smoothly limited mass. Demonstration of the findings to , who recommends taking a forceps biopsy. Now advance the forceps over the working channel and take 3 representative samples from the exophytic mass. Finally, there is no relevant bleeding. Further retraction of the esophagoscope. Further cranial than 40 cm from the tooth row, the mucosa is completely normal and smooth. Now insert a mouth guard and inspect the rest of the oropharynx. The posterior and lateral walls of the oropharynx are free, as are the valleculae, the base of the tongue, which is symmetrically slightly hyperplastic, the lateral walls of the hypopharynx, the posterior wall of the hypopharynx and both piriform sinuses are free and can be freely unfolded. The esophageal inlet can also be freely unfolded with inconspicuous mucosal conditions. Direct laryngoscopy reveals an inconspicuous posterior and anterior commissure, the interary area is clear, as are the folds of the pouch, the morgue sinus and the vocal folds. The Mc Ivor mouth retractor is now inserted again and a velotractio is inserted on both sides. In the nasopharynx, slightly left-accentuated minor adenoids are seen, which are curetted out with the Beckmann ring knife under vision and sent for final histology. Finally, hemostasis with the bipolar. Removal of the mouth guard and insertion of the mouth guard and insertion of the Kleinsasser B-tube for re-inspection of the base of the tongue. There are no abnormalities here. Decision to take 2 representative samples each from the middle of the tongue base and the right and left sides. Final hemostasis with the monopolar. The frozen section result of is now transmitted. It shows a basaloid squamous cell carcinoma of the left tonsil, which was resected practically on all sides R1. Discussion of the findings with and acceptance of the operation by for resection. This is done using the monopolar knife, bipolar and scissors. The resected specimen and representative marginal samples are submitted for final histology. The gl. submandibularis is now exposed laterocaudally. Final hemostasis with the bipolar. Removal of the swabs from the nasopharynx and, after re-inspection of the tonsil larynx and nasopharynx, termination of the operation with absolute hemostasis. Conclusion: V.a. cT2 cN1 basaloid squamous cell carcinoma of the left tonsil. After receipt of the final histology, neck dissection of the left side and PEG placement must definitely be planned with regard to an upcoming adjuvant radiochemotherapy. Please also note the histology from the esophageal mass 42 cm from the ZR. Depending on the final R status and swallowing function, a further resection and/or radial flap coverage must also be considered. According to , flap coverage is required in the case of an R1 situation towards the palatal arch, medially and laterally. If there is an R1 situation towards the base of the tongue, another transoral resection could be performed. \ No newline at end of file diff --git a/680/InvasionFront_CD3_block7_x5_y8_patient680_0.json b/680/InvasionFront_CD3_block7_x5_y8_patient680_0.json new file mode 100644 index 0000000000000000000000000000000000000000..87c4772fad5156f001a61fad2a4d32d1fcd1a7cb --- /dev/null +++ b/680/InvasionFront_CD3_block7_x5_y8_patient680_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16516.3, + "Centroid Y µm": 19689.6, + "Num Detections": 12883, + "Num Negative": 12653, + "Num Positive": 230, + "Positive %": 1.785, + "Num Positive per mm^2": 133.69 + } +} \ No newline at end of file diff --git a/680/InvasionFront_CD3_block7_x6_y8_patient680_1.json b/680/InvasionFront_CD3_block7_x6_y8_patient680_1.json new file mode 100644 index 0000000000000000000000000000000000000000..91a1b45e749de4c5e5dc731694a716e38b766301 --- /dev/null +++ b/680/InvasionFront_CD3_block7_x6_y8_patient680_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 19539.7, + "Num Detections": 26167, + "Num Negative": 15746, + "Num Positive": 10421, + "Positive %": 39.82, + "Num Positive per mm^2": 4011.0 + } +} \ No newline at end of file diff --git a/680/InvasionFront_CD8_block7_x5_y8_patient680_0.json b/680/InvasionFront_CD8_block7_x5_y8_patient680_0.json new file mode 100644 index 0000000000000000000000000000000000000000..06550d288d0c320689b5827d427aec36b6aca835 --- /dev/null +++ b/680/InvasionFront_CD8_block7_x5_y8_patient680_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16741.1, + "Centroid Y µm": 20963.9, + "Num Detections": 14627, + "Num Negative": 14377, + "Num Positive": 250, + "Positive %": 1.709, + "Num Positive per mm^2": 136.86 + } +} \ No newline at end of file diff --git a/680/InvasionFront_CD8_block7_x6_y8_patient680_1.json b/680/InvasionFront_CD8_block7_x6_y8_patient680_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5c60fd9bd36f71e64cfe25df626a36019bd5ae54 --- /dev/null +++ b/680/InvasionFront_CD8_block7_x6_y8_patient680_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19314.8, + "Centroid Y µm": 21363.7, + "Num Detections": 27774, + "Num Negative": 23795, + "Num Positive": 3979, + "Positive %": 14.33, + "Num Positive per mm^2": 1587.3 + } +} \ No newline at end of file diff --git a/680/TumorCenter_CD3_block7_x5_y8_patient680_0.json b/680/TumorCenter_CD3_block7_x5_y8_patient680_0.json new file mode 100644 index 0000000000000000000000000000000000000000..49594b05db4efcb74b556ae80fdeb3eecf0b31b1 --- /dev/null +++ b/680/TumorCenter_CD3_block7_x5_y8_patient680_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 20289.3, + "Num Detections": 15437, + "Num Negative": 7387, + "Num Positive": 8050, + "Positive %": 52.15, + "Num Positive per mm^2": 4631.2 + } +} \ No newline at end of file diff --git a/680/TumorCenter_CD3_block7_x6_y8_patient680_1.json b/680/TumorCenter_CD3_block7_x6_y8_patient680_1.json new file mode 100644 index 0000000000000000000000000000000000000000..edc3495edc6846ba9b2fa5ed3f928f71e53a1099 --- /dev/null +++ b/680/TumorCenter_CD3_block7_x6_y8_patient680_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 20289.3, + "Num Detections": 17152, + "Num Negative": 9675, + "Num Positive": 7477, + "Positive %": 43.59, + "Num Positive per mm^2": 3737.3 + } +} \ No newline at end of file diff --git a/680/TumorCenter_CD8_block7_x5_y8_patient680_0.json b/680/TumorCenter_CD8_block7_x5_y8_patient680_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6ea5af08e266825e688bcbda12667be7b97d7410 --- /dev/null +++ b/680/TumorCenter_CD8_block7_x5_y8_patient680_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 20114.3, + "Num Detections": 21776, + "Num Negative": 19670, + "Num Positive": 2106, + "Positive %": 9.671, + "Num Positive per mm^2": 1134.5 + } +} \ No newline at end of file diff --git a/680/TumorCenter_CD8_block7_x6_y8_patient680_1.json b/680/TumorCenter_CD8_block7_x6_y8_patient680_1.json new file mode 100644 index 0000000000000000000000000000000000000000..794e3b6e3e9b71adbbb3fd125e285f5b315431af --- /dev/null +++ b/680/TumorCenter_CD8_block7_x6_y8_patient680_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 20114.3, + "Num Detections": 21263, + "Num Negative": 19231, + "Num Positive": 2032, + "Positive %": 9.557, + "Num Positive per mm^2": 1008.8 + } +} \ No newline at end of file diff --git a/680/history_text.txt b/680/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/680/icd_codes.txt b/680/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d31171e18b134e378542c20d6016c0461028b4c --- /dev/null +++ b/680/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Tonsille, mehrere Teilbereiche überlappend[C09.8 ] \ No newline at end of file diff --git a/680/ops_codes.txt b/680/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3a8a66351541d2d5950351ba51685b56bedab1a0 --- /dev/null +++ b/680/ops_codes.txt @@ -0,0 +1 @@ +Selektive Neck dissection in 5 Regionen[5-403.04 B] Transorale Tumortonsillektomie[5-281.2 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Weichgaumenteilresektion[5-272.1 ] \ No newline at end of file diff --git a/680/patient_clinical_data.json b/680/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..183b1e52d62009eb62ad3921bf165976bbf3d39c --- /dev/null +++ b/680/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 56, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/680/patient_pathological_data.json b/680/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..da5c82fcf526f5703f6ebfead81ffbc60014ec56 --- /dev/null +++ b/680/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "680", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 19, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/680/surgery_description.txt b/680/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..de53af734a0a08a30633a6d157d9f482b02001a2 --- /dev/null +++ b/680/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Functional neck dissection, Tracheotomy diff --git a/680/surgery_report.txt b/680/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..18606ad9d369df04b8cd0edbf369ca0e2950f582 --- /dev/null +++ b/680/surgery_report.txt @@ -0,0 +1 @@ +First insertion of the tonsil plug and inspection of the tumor region. The tonsils can be palpated on the right side. There is a hard tumor submucosally. Tumor resection by , who first begins the resection with the electric needle right next to the uvula on the anterior palatal arch. Part of the anterior palatal arch is removed. Then transition to the lateral pharyngeal wall and dissection of the tonsil, including a small muscular cuff. The base of the tongue itself is free and does not need to be resected. A portion of the posterior palatal arch can be left. The preparation is thread-marked for the frozen section. In the area of the anterior palatal arch, a marginal sample is taken directly after the tumor resection, which is also thread-marked and sent for histology. The pathologists still found tumor cells in the basal area, so a generous resection is performed in the area of the anterior palatal arch, the lateral pharyngeal wall and the basal tonsillar lobe area. No further resection is possible here, as small areas of fat from the neck are already visible. However, the resected area is tumor-free. Then neck dissection on the left side. Skin incision in the usual manner. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle. Exposure of the accessory muscle, then the submandibular gland and the digastric muscle. Exposure of the cervical vascular sheath. Dissection of the internal jugular vein. Evacuation of levels II, III and IV. Intraoperatively, the decision is made to also evacuate level V, as there are some visible lymph nodes here. Neck dissection on the right side. After discussion with , the decision was made to perform a neck dissection on the right side. However, to proceed very carefully in the area of the submandibular gland so as not to produce a fistula. Skin incision in the usual manner. Exposure of the sternocleidomastoid muscle anterior margin, exposure of the omohyoid muscle. Then explore the submandibular gland, proceeding with extreme caution so that the gland is not completely dislocated. Exposure of the digastric muscle. Very careful dissection here too. Free dissection of the internal jugular vein. Level II shows a soft, cystic mass, which initially does not look metastatic; from the macroscopic aspect it could be a cystadenolymphoma of the parotid gland or a lymphangioma, which is demonstrated intraoperatively to . He recommends removing this mass anyway. To do this, the skin incision is widened slightly and the mass is removed completely. Then clearing out level IIa to Va while sparing the accessorius nerve and the plexus branches. Exposure of the hypoglossal nerve, which can also be preserved. Then perform a tracheotomy. Skin incision in the usual manner. Dissection down to the musculature. Push the muscles to the side in the midline. Exposure of the thyroid isthmus, which is very small and can be coagulated and transected in a bipolar fashion. Exposure of the trachea. Entering the trachea between the 1st and 2nd tracheal cartilage. Creation of a visor tracheotomy. Creation of a mucocutaneous anastomosis and insertion of a size 8 tracheal cannula. Continue antibiotics postoperatively. No oral food on the day of surgery. On the next day, please demonstrate to the surgeon; fluids can probably already be started. Otherwise, present the patient to the tumor conference. \ No newline at end of file diff --git a/681/InvasionFront_CD3_block17_x1_y6_patient681_0.json b/681/InvasionFront_CD3_block17_x1_y6_patient681_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3d7ab3870c4375f1304f1a97331889f4b036085e --- /dev/null +++ b/681/InvasionFront_CD3_block17_x1_y6_patient681_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 19864.5, + "Num Detections": 18756, + "Num Negative": 17786, + "Num Positive": 970, + "Positive %": 5.172, + "Num Positive per mm^2": 425.76 + } +} \ No newline at end of file diff --git a/681/InvasionFront_CD3_block17_x2_y6_patient681_1.json b/681/InvasionFront_CD3_block17_x2_y6_patient681_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c23735dfc4475dca123ad164756d81fbd09e316 --- /dev/null +++ b/681/InvasionFront_CD3_block17_x2_y6_patient681_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6196.7, + "Centroid Y µm": 19989.4, + "Num Detections": 18527, + "Num Negative": 17551, + "Num Positive": 976, + "Positive %": 5.268, + "Num Positive per mm^2": 442.11 + } +} \ No newline at end of file diff --git a/681/InvasionFront_CD8_block17_x1_y6_patient681_0.json b/681/InvasionFront_CD8_block17_x1_y6_patient681_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f8936f74355233ad081f3c3229cdadfdf6c868a6 --- /dev/null +++ b/681/InvasionFront_CD8_block17_x1_y6_patient681_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 15316.9, + "Num Detections": 17768, + "Num Negative": 17280, + "Num Positive": 488, + "Positive %": 2.747, + "Num Positive per mm^2": 225.33 + } +} \ No newline at end of file diff --git a/681/InvasionFront_CD8_block17_x2_y6_patient681_1.json b/681/InvasionFront_CD8_block17_x2_y6_patient681_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e15c9cbd0e5a9b01d96ce39be8ffc9d7a5aa0326 --- /dev/null +++ b/681/InvasionFront_CD8_block17_x2_y6_patient681_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6521.5, + "Centroid Y µm": 15341.9, + "Num Detections": 16111, + "Num Negative": 15841, + "Num Positive": 270, + "Positive %": 1.676, + "Num Positive per mm^2": 143.87 + } +} \ No newline at end of file diff --git a/681/TumorCenter_CD3_block17_x1_y6_patient681_0.json b/681/TumorCenter_CD3_block17_x1_y6_patient681_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b5ab3c211c55ed139eb8564c98b4ef71d4abf3aa --- /dev/null +++ b/681/TumorCenter_CD3_block17_x1_y6_patient681_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 15067.0, + "Num Detections": 17973, + "Num Negative": 16073, + "Num Positive": 1900, + "Positive %": 10.57, + "Num Positive per mm^2": 904.37 + } +} \ No newline at end of file diff --git a/681/TumorCenter_CD3_block17_x2_y6_patient681_1.json b/681/TumorCenter_CD3_block17_x2_y6_patient681_1.json new file mode 100644 index 0000000000000000000000000000000000000000..565f38e2aa1ccde33dc46f420d031c83dbc17036 --- /dev/null +++ b/681/TumorCenter_CD3_block17_x2_y6_patient681_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6146.7, + "Centroid Y µm": 14867.1, + "Num Detections": 20000, + "Num Negative": 17265, + "Num Positive": 2735, + "Positive %": 13.68, + "Num Positive per mm^2": 1115.5 + } +} \ No newline at end of file diff --git a/681/TumorCenter_CD8_block17_x1_y6_patient681_0.json b/681/TumorCenter_CD8_block17_x1_y6_patient681_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69b7b7d5455a2b24c6f9af8815d85658e1008601 --- /dev/null +++ b/681/TumorCenter_CD8_block17_x1_y6_patient681_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6403.6, + "Centroid Y µm": 28808.5, + "Num Detections": 21771, + "Num Negative": 19981, + "Num Positive": 1790, + "Positive %": 8.222, + "Num Positive per mm^2": 724.88 + } +} \ No newline at end of file diff --git a/681/TumorCenter_CD8_block17_x2_y6_patient681_1.json b/681/TumorCenter_CD8_block17_x2_y6_patient681_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aa5d5ec81c85f4dc91e31810b51d87ec6980e119 --- /dev/null +++ b/681/TumorCenter_CD8_block17_x2_y6_patient681_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8995.2, + "Centroid Y µm": 28609.9, + "Num Detections": 20213, + "Num Negative": 18849, + "Num Positive": 1364, + "Positive %": 6.748, + "Num Positive per mm^2": 593.97 + } +} \ No newline at end of file diff --git a/681/history_text.txt b/681/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/681/icd_codes.txt b/681/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/681/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/681/ops_codes.txt b/681/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2416c2c4b6ff819b024f4f963fff398b9b9865c0 --- /dev/null +++ b/681/ops_codes.txt @@ -0,0 +1 @@ +Partielle Larynx-Pharynx-Resektion[5-302.4 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Permanente Tracheostomaanlage[5-312.0 ] \ No newline at end of file diff --git a/681/patient_clinical_data.json b/681/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b05d9487bb27558453297f64c2c7609c236a2183 --- /dev/null +++ b/681/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 22, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/681/patient_pathological_data.json b/681/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6cd099aae7614a367c7cbd1993b47f3c321fc880 --- /dev/null +++ b/681/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "681", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 29, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.5 +} \ No newline at end of file diff --git a/681/surgery_description.txt b/681/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..231433b24a892a56587ef7b0ccedf1c6e318771f --- /dev/null +++ b/681/surgery_description.txt @@ -0,0 +1 @@ +Larynx-pharynx partial resection, Selective neck dissection bilateral Level II - V, Tracheostomy, Nasogastric feeding tube diff --git a/681/surgery_report.txt b/681/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ddc8e87c7edbe5572c250f344bbae60ed98ba50 --- /dev/null +++ b/681/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, transoral laser surgical tumor resection is performed first. After positioning the larynx with the Weerda laryngoscope, the epiglottis is first cut at the transition from the lateral to the medial third and followed into the vallecula at an appropriate safety distance from the tumor. The tumor is then removed caudally and medially from the upper edge of the arytenoid cartilage, which is exposed in its upper third. The tumor is then resected dorsally along the supraglottis. Resection then begins from the lateral hypopharyngeal wall with an appropriate safety distance to the tumor. The resection is then continued cranially in the direction of the vallecula and joined with the incision from the base of the epiglottis. Finally, the tumor is also completely removed caudally, leaving out the tip of the piriform sinus. The specimen is then thread-marked and mounted on cork and sent to the pathology department for frozen section histology. Here, all marginal incisions as well as the one incision from the base of the tumor are found to be tumor-free. Finally, careful hemostasis by monopolar coagulation in the resection area. This involved clipping a small arterial branch in the lateral pharyngeal wall. Now insertion of a gastric tube under visualization, the correct position of which is also checked and confirmed by auscultation. Then transition to neck dissection on the right side. After a skin incision in the area of the front edge of the sternocleidomastoid muscle, regions II to V are successively removed. All non-lymphatic structures are spared and remain intact. Once the neck dissection preparation has been removed, careful hemostasis is performed. Insertion of a Redon suction drain. Two-layer wound closure. Subsequent transition to the left side. Similar procedure here. Here too, regions II to V are successively evacuated while preserving all non-lymphatic structures. There is no indication of a lymph node metastasis. Insertion of a Redon suction drain and subsequent wound closure. The surgical site was then checked. This revealed the now quite large resection area on the left side. The decision was therefore made to perform a protective tracheostomy. A transverse skin incision about 3 cm long was made and the linea alba was dissected. Dissection of the straight neck muscles with exposure of the thyroid isthmus. This is passed under the pretracheal lamina, clamped and stitched around. This exposes the upper trachea. Entrance between the 2nd and 3rd tracheal clasp in the sense of a visual tracheostomy. Placement of 2 upper and 2 lower sutures for the mucocutaneous anastomosis. Subsequently, the patient was reintubated onto an 8-gauge tracheostomy tube without any problems. Sterile wound dressing. Transfer of the patient to anesthesia. Conclusion: Transoral laser-surgical partial laryngeal/pharyngeal resection for a carcinoma of the aryepiglottic fold. Selective neck dissection of regions II to V on both sides. Insertion of a plastic tracheostoma and a transnasal feeding tube. \ No newline at end of file diff --git a/682/InvasionFront_CD3_block7_x5_y11_patient682_0.json b/682/InvasionFront_CD3_block7_x5_y11_patient682_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0760fbff77515a359ef4707f4ef55c16af2126e0 --- /dev/null +++ b/682/InvasionFront_CD3_block7_x5_y11_patient682_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 26535.9, + "Num Detections": 18317, + "Num Negative": 18228, + "Num Positive": 89, + "Positive %": 0.4859, + "Num Positive per mm^2": 35.29 + } +} \ No newline at end of file diff --git a/682/InvasionFront_CD3_block7_x6_y11_patient682_1.json b/682/InvasionFront_CD3_block7_x6_y11_patient682_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f919bf8fbce09c0df64ed068d058641e15c40666 --- /dev/null +++ b/682/InvasionFront_CD3_block7_x6_y11_patient682_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 26486.0, + "Num Detections": 24202, + "Num Negative": 23736, + "Num Positive": 466, + "Positive %": 1.925, + "Num Positive per mm^2": 180.02 + } +} \ No newline at end of file diff --git a/682/InvasionFront_CD8_block7_x5_y11_patient682_0.json b/682/InvasionFront_CD8_block7_x5_y11_patient682_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e332887f2c48014f2c4f65e796e5fe0dacedaa0a --- /dev/null +++ b/682/InvasionFront_CD8_block7_x5_y11_patient682_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 28185.1, + "Num Detections": 22175, + "Num Negative": 21776, + "Num Positive": 399, + "Positive %": 1.799, + "Num Positive per mm^2": 156.99 + } +} \ No newline at end of file diff --git a/682/InvasionFront_CD8_block7_x6_y11_patient682_1.json b/682/InvasionFront_CD8_block7_x6_y11_patient682_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2ca239d1376da8c2be5ce39dbf89c74613e43e5 --- /dev/null +++ b/682/InvasionFront_CD8_block7_x6_y11_patient682_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18340.3, + "Centroid Y µm": 28484.9, + "Num Detections": 23749, + "Num Negative": 22967, + "Num Positive": 782, + "Positive %": 3.293, + "Num Positive per mm^2": 298.97 + } +} \ No newline at end of file diff --git a/682/TumorCenter_CD3_block7_x5_y11_patient682_0.json b/682/TumorCenter_CD3_block7_x5_y11_patient682_0.json new file mode 100644 index 0000000000000000000000000000000000000000..849f2bd5e6e27544f47879807d5ae3e8db680445 --- /dev/null +++ b/682/TumorCenter_CD3_block7_x5_y11_patient682_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 27885.2, + "Num Detections": 21231, + "Num Negative": 20890, + "Num Positive": 341, + "Positive %": 1.606, + "Num Positive per mm^2": 137.55 + } +} \ No newline at end of file diff --git a/682/TumorCenter_CD3_block7_x6_y11_patient682_1.json b/682/TumorCenter_CD3_block7_x6_y11_patient682_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b58822b373856df91abee65b05d83f6c68b3e40 --- /dev/null +++ b/682/TumorCenter_CD3_block7_x6_y11_patient682_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18315.3, + "Centroid Y µm": 27735.3, + "Num Detections": 20110, + "Num Negative": 19496, + "Num Positive": 614, + "Positive %": 3.053, + "Num Positive per mm^2": 234.11 + } +} \ No newline at end of file diff --git a/682/TumorCenter_CD8_block7_x5_y11_patient682_0.json b/682/TumorCenter_CD8_block7_x5_y11_patient682_0.json new file mode 100644 index 0000000000000000000000000000000000000000..434edc4ab437ddb2a1cab8d249fef020f243816c --- /dev/null +++ b/682/TumorCenter_CD8_block7_x5_y11_patient682_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15441.8, + "Centroid Y µm": 27560.4, + "Num Detections": 21294, + "Num Negative": 19465, + "Num Positive": 1829, + "Positive %": 8.589, + "Num Positive per mm^2": 725.47 + } +} \ No newline at end of file diff --git a/682/TumorCenter_CD8_block7_x6_y11_patient682_1.json b/682/TumorCenter_CD8_block7_x6_y11_patient682_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7d90a4adb3a0a0f7dfa59be8b93456ab8892ca2d --- /dev/null +++ b/682/TumorCenter_CD8_block7_x6_y11_patient682_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 27360.5, + "Num Detections": 23224, + "Num Negative": 22442, + "Num Positive": 782, + "Positive %": 3.367, + "Num Positive per mm^2": 298.32 + } +} \ No newline at end of file diff --git a/682/history_text.txt b/682/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc8b0c77b47234399d203388f3f1ab5a572afa84 --- /dev/null +++ b/682/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2, cN2b G2 oropharyngeal carcinoma on the right side was histologically confirmed as early as <2005> during a panendoscopy. In our interdisciplinary tumor conference, primary surgical treatment was recommended, but the planned definitive treatment was then rejected by the patient <2014>. After undergoing alcohol withdrawal, however, the patient still wanted the recommended treatment. Preoperative CT showed circumscribed tumor growth, overall sonographic cN2b neck status and cM0 situation in CT diagnostics. \ No newline at end of file diff --git a/682/icd_codes.txt b/682/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/682/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/682/patient_clinical_data.json b/682/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e15b324cf1bf6d6b0a1efa99c56730931ed8bd83 --- /dev/null +++ b/682/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 105, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin + Paclitaxel", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/682/patient_pathological_data.json b/682/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2d246b1a5cbfff576627323e5a8cc6a0b802baa7 --- /dev/null +++ b/682/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "682", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.4", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/683/InvasionFront_CD3_block17_x3_y5_patient683_0.json b/683/InvasionFront_CD3_block17_x3_y5_patient683_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff5bd5ad90e8f3a65c3d7b11eaa377c570b656ec --- /dev/null +++ b/683/InvasionFront_CD3_block17_x3_y5_patient683_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 17665.6, + "Num Detections": 22796, + "Num Negative": 22374, + "Num Positive": 422, + "Positive %": 1.851, + "Num Positive per mm^2": 151.48 + } +} \ No newline at end of file diff --git a/683/InvasionFront_CD3_block17_x4_y5_patient683_1.json b/683/InvasionFront_CD3_block17_x4_y5_patient683_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd286bd0ede7eb57cf836b88b60cc2824ed8226f --- /dev/null +++ b/683/InvasionFront_CD3_block17_x4_y5_patient683_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 17740.6, + "Num Detections": 24496, + "Num Negative": 24149, + "Num Positive": 347, + "Positive %": 1.417, + "Num Positive per mm^2": 128.51 + } +} \ No newline at end of file diff --git a/683/InvasionFront_CD8_block17_x3_y5_patient683_0.json b/683/InvasionFront_CD8_block17_x3_y5_patient683_0.json new file mode 100644 index 0000000000000000000000000000000000000000..86b2e361d5d883415efea5a235280c02981b3637 --- /dev/null +++ b/683/InvasionFront_CD8_block17_x3_y5_patient683_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11144.1, + "Centroid Y µm": 12843.2, + "Num Detections": 23103, + "Num Negative": 22951, + "Num Positive": 152, + "Positive %": 0.6579, + "Num Positive per mm^2": 55.2 + } +} \ No newline at end of file diff --git a/683/InvasionFront_CD8_block17_x4_y5_patient683_1.json b/683/InvasionFront_CD8_block17_x4_y5_patient683_1.json new file mode 100644 index 0000000000000000000000000000000000000000..df893d75e92f010d432d92d7f36e7d61e2bb7e6e --- /dev/null +++ b/683/InvasionFront_CD8_block17_x4_y5_patient683_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 12893.2, + "Num Detections": 23912, + "Num Negative": 23789, + "Num Positive": 123, + "Positive %": 0.5144, + "Num Positive per mm^2": 46.09 + } +} \ No newline at end of file diff --git a/683/TumorCenter_CD3_block17_x3_y5_patient683_0.json b/683/TumorCenter_CD3_block17_x3_y5_patient683_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7a873d7e87534893ecfe1530df020d8b30acaf62 --- /dev/null +++ b/683/TumorCenter_CD3_block17_x3_y5_patient683_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 12443.4, + "Num Detections": 24079, + "Num Negative": 23625, + "Num Positive": 454, + "Positive %": 1.885, + "Num Positive per mm^2": 162.67 + } +} \ No newline at end of file diff --git a/683/TumorCenter_CD3_block17_x4_y5_patient683_1.json b/683/TumorCenter_CD3_block17_x4_y5_patient683_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fd86e0997105c05269e5aaa6d289f373b00dc65c --- /dev/null +++ b/683/TumorCenter_CD3_block17_x4_y5_patient683_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 12518.4, + "Num Detections": 24770, + "Num Negative": 24043, + "Num Positive": 727, + "Positive %": 2.935, + "Num Positive per mm^2": 263.39 + } +} \ No newline at end of file diff --git a/683/TumorCenter_CD8_block17_x3_y5_patient683_0.json b/683/TumorCenter_CD8_block17_x3_y5_patient683_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08aee02f4945aa712cc1facb36bb4ce22551f2bb --- /dev/null +++ b/683/TumorCenter_CD8_block17_x3_y5_patient683_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 26186.1, + "Num Detections": 22656, + "Num Negative": 22518, + "Num Positive": 138, + "Positive %": 0.6091, + "Num Positive per mm^2": 50.51 + } +} \ No newline at end of file diff --git a/683/patient_pathological_data.json b/683/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d525806903d75fa8ead2c9d4216c7987f1e72f4a --- /dev/null +++ b/683/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "683", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.5 +} \ No newline at end of file