diff --git a/375/icd_codes.txt b/375/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..10623317f12e2cf8eb61e998e27f4b464b164dc5 --- /dev/null +++ b/375/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B] \ No newline at end of file diff --git a/375/surgery_description.txt b/375/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9124a801557bbcd31cd8106a9575319087a8c8f4 --- /dev/null +++ b/375/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Provox insertion, Pharyngoscopy, Laryngoscopy diff --git a/375/surgery_report.txt b/375/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d6ab6cce2e1e743a89d7a410f033a0ea89807c86 --- /dev/null +++ b/375/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy and laryngoscopy again, showing the exophytic tumor, which runs from the interary area centrally over both vocal folds, the anterior commissure to the arytenoid region on the left. Overall, not a large voluminous tumor, but rather a very extensive flat finding, which makes a larynx-preserving procedure inappropriate. Cartilage infiltration in the area of the anterior commissure, at least from the inside, cannot be ruled out. Therefore, repositioning for surgical therapy. Skin disinfection. Sterile draping. Injection of a total of 10 ml Ultracaine 1% with adrenaline in the area of the planned incision. Then elevation of the apron flap and neck dissection on both sides. Start with the neck dissection on the left side: dissection of the sternocleidomastoid muscle, exposure and protection of the XI nerve. Dissection of the cranial border with exposure of the lower edge of the gl. submandibularis and the digaster muscle. Locate and dissect the omohyoid muscle. No macroscopically suspicious nodes. On this side, regions Ib-V are completely removed while preserving all non-lymphatic structures. Transition to neck dissection on the right side, here the procedure is carried out in the same way. Final demonstration of findings on ." Subsequent laryngectomy: Dissection of the suprahyoid muscles from the hyoid bone, which is completely skeletonized. Exposure of the superior chorda on both sides and release of this on both sides. Exposure of the thyroid gland on both sides, transection of the isthmus. Thyroid gland is dissected caudo-laterally on both sides. Infrahyoid muscles are detached from the hyoid bone and beaten downwards. Constrictor muscle, pharynx with pharyngeal tube is dissected away from the pharyngeal skeleton as far as possible. Tracheotomy is then performed. Re-intubation. Then enter the larynx in the area of the epiglottis. The area of the lingual epiglottis mucosa is spared as far as possible. Then successive release of the larynx with maximum preservation of the pharyngeal mucosa. Separate the laryngeal skeleton from the pharyngeal tube up to the beginning of the trachea. Here the larynx is set down in a typical manner. In the case of subglottic growth, creation of the tracheostoma in the typical manner. Larynx is sent in for frozen section, here in frozen section cranial and caudal in the area of the mucosal settling points or trachea and epiglottis in sano. Subsequently, myotomy on the left side in the typical manner. The muscles of the pharyngeal tube are severed. Then separation of the sternocleidomastoid muscle in the area of the medial insertions on both sides. Then insertion of a 10 mm Provox prosthesis in the typical manner. This is positioned correctly. Then closure of the pharynx in a single layer using single button sutures. Further inverted suture in the second layer. Suturing of the pharyngeal tube or constrictor pharyngis and suprahyoidal muscles cranially, also using single Vicryl 3-0 button sutures. Then irrigation and careful hemostasis. Wound closure in layers with insertion of Redon drainage on both sides and epithelialization of the tracheostoma. Subsequent completion of the procedure without complications. Overall cT3-4 carcinoma endolaryngeal. Due to questionable cartilage infiltration to the front and the overall extension, laryngectomy was performed with neck dissection on both sides. Please feed via the inserted nasogastric tube for 8-10 days, then after swallowing gruel, if necessary, build up the diet. Please continue antibiotics, which were started with Unacid, for one week. After receiving the final histology, please attend the interdisciplinary tumor conference for further treatment planning. \ No newline at end of file diff --git a/376/InvasionFront_CD3_block5_x5_y8_patient376_0.json b/376/InvasionFront_CD3_block5_x5_y8_patient376_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff9a92671fe93e63b83fb7728db651edcb551ed3 --- /dev/null +++ b/376/InvasionFront_CD3_block5_x5_y8_patient376_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 20414.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/376/InvasionFront_CD3_block5_x6_y8_patient376_1.json b/376/InvasionFront_CD3_block5_x6_y8_patient376_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f350c626ba42f45e72d147fa0a8c3a838ee54fba --- /dev/null +++ b/376/InvasionFront_CD3_block5_x6_y8_patient376_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 20389.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/376/InvasionFront_CD8_block5_x5_y6_patient376_0.json b/376/InvasionFront_CD8_block5_x5_y6_patient376_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ce2e1a82a5a18826658c89682dd9df1eadb09954 --- /dev/null +++ b/376/InvasionFront_CD8_block5_x5_y6_patient376_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 15366.9, + "Num Detections": 21036, + "Num Negative": 20691, + "Num Positive": 345, + "Positive %": 1.64, + "Num Positive per mm^2": 138.12 + } +} \ No newline at end of file diff --git a/376/InvasionFront_CD8_block5_x6_y6_patient376_1.json b/376/InvasionFront_CD8_block5_x6_y6_patient376_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cf17362b3a51c00c9742f1ad9e6b31655ad48068 --- /dev/null +++ b/376/InvasionFront_CD8_block5_x6_y6_patient376_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 15466.8, + "Num Detections": 23202, + "Num Negative": 22987, + "Num Positive": 215, + "Positive %": 0.9266, + "Num Positive per mm^2": 82.24 + } +} \ No newline at end of file diff --git a/376/TumorCenter_CD3_block5_x5_y6_patient376_0.json b/376/TumorCenter_CD3_block5_x5_y6_patient376_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0f31607036c078087b218a6a2566a866705822d1 --- /dev/null +++ b/376/TumorCenter_CD3_block5_x5_y6_patient376_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17066.0, + "Centroid Y µm": 15441.8, + "Num Detections": 23360, + "Num Negative": 22635, + "Num Positive": 725, + "Positive %": 3.104, + "Num Positive per mm^2": 273.84 + } +} \ No newline at end of file diff --git a/376/TumorCenter_CD3_block5_x6_y6_patient376_1.json b/376/TumorCenter_CD3_block5_x6_y6_patient376_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f0e22cef9d5dbc513573820d399845b7d25e18f5 --- /dev/null +++ b/376/TumorCenter_CD3_block5_x6_y6_patient376_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19614.6, + "Centroid Y µm": 15716.7, + "Num Detections": 22701, + "Num Negative": 21528, + "Num Positive": 1173, + "Positive %": 5.167, + "Num Positive per mm^2": 430.36 + } +} \ No newline at end of file diff --git a/376/TumorCenter_CD8_block5_x5_y6_patient376_0.json b/376/TumorCenter_CD8_block5_x5_y6_patient376_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9d586efd6c30dedf0c0075a000542d330235e181 --- /dev/null +++ b/376/TumorCenter_CD8_block5_x5_y6_patient376_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 15192.0, + "Num Detections": 22861, + "Num Negative": 22708, + "Num Positive": 153, + "Positive %": 0.6693, + "Num Positive per mm^2": 57.77 + } +} \ No newline at end of file diff --git a/376/TumorCenter_CD8_block5_x6_y6_patient376_1.json b/376/TumorCenter_CD8_block5_x6_y6_patient376_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2248a093df00cc72043e7898620b0a1c9beeeeb8 --- /dev/null +++ b/376/TumorCenter_CD8_block5_x6_y6_patient376_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 15241.9, + "Num Detections": 22223, + "Num Negative": 21866, + "Num Positive": 357, + "Positive %": 1.606, + "Num Positive per mm^2": 131.48 + } +} \ No newline at end of file diff --git a/376/history_text.txt b/376/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..634acef15afd1ca9023d4711be21d01d4a31c0d0 --- /dev/null +++ b/376/history_text.txt @@ -0,0 +1 @@ +The patient has been suffering from difficulty swallowing in the right-sided tongue area for 1 year. The panendoscopy revealed a squamous cell carcinoma G1. \ No newline at end of file diff --git a/376/icd_codes.txt b/376/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/376/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/376/ops_codes.txt b/376/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6365db9b4a03a45effba8004ab70663c1d194c5 --- /dev/null +++ b/376/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroduodenoskopie bei normalem Situs[1-632.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Gaumentumorexzision[5-272.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] Transplantat[5-295.14 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme freier Radialis-Lappen[5-858.23 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Entfernung Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R] \ No newline at end of file diff --git a/376/patient_clinical_data.json b/376/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b821595885723e09c68976eba3aee791e1197ceb --- /dev/null +++ b/376/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/376/patient_pathological_data.json b/376/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..15e55d761afd1b7dd9b15bd8484fa594e35b9e15 --- /dev/null +++ b/376/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "376", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/376/surgery_description.txt b/376/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..03c869fa46946c186c5ba5338d72121be399569a --- /dev/null +++ b/376/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Flap coverage, Free flap (Radial), Tracheotomy, PEG placement diff --git a/376/surgery_report.txt b/376/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..049e4b3fa466b2d19a2b5fb5e7348e42a2914770 --- /dev/null +++ b/376/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then first sterile washing and draping of the neck area and performance of the tracheotomy by and , here skin incision below the cricoid cartilage, preparation of the prelaryngeal musculature, splitting of the musculature at the linea alba. Exposure of the thyroid isthmus, separation of the thyroid isthmus. Exposure of the anterior wall of the trachea. Insertion between the 2nd and 3rd tracheal cartilage. Creation of a visor tracheotomy. Then repositioning and remaining washing and draping. Neck dissection on the right, PEG placement and tracheostomy by . Start of PEG insertion: insertion with the flexible oesophagogastroscope and easy pre-scanning with air insufflation into the stomach. Positive diaphanoscopy and problem-free placement of a PEG using the thread pull-through method without any problems. Dressing application. Transition to tracheotomy: positioning of the patient and marking of the incision and skin incision, subcutaneous preparation, pushing apart the infrahyoid muscles and exposing the thyroid isthmus. Undermining of the same, bipolar coagulation and separation of the isthmus from the trachea. Locate the space between the 2nd and 3rd tracheal cartilage and carefully enter. Creation of a visor tracheotomy. Transfer to a laryngectomy tube. Repositioning for tumor removal and neck dissection, primarily on the right side. Injection of 10 ml local anesthetic with adrenaline along the planned incision and along the right side of the neck. Skin incision, exposure of the sternocleidomastoid muscle, exposure of its profound surface, exposure and sparing of the accessorius nerve. Exposure of the posterior belly of the digastric muscle. Exposure and protection of the hypoglossal nerve. Exposure of the cervical vascular sheath. Visualization of the vagus nerve. Dissection of the lateral neck preparation, transection in the cranial area. Removal of the submandibular gland together with the attached lymph nodes. Dissection and gentle removal of the facial artery as a connecting vessel for subsequent flap preparation. Separation of the facial vein. Dissection inferiorly and exposure of the omohyoid muscle. Further dissection in a superior direction and lifting of the medial neck preparation. Hemostasis and leaving the site open for later flap preparation. Simultaneously, the tumor is released enorally by and counter-operated on transcervically. This is followed by transoral, transcervical tumor resection: first insertion of the Mc Ivor blade and re-inspection of the tumor. The tumor is mainly located in the middle to lower part of the tonsillar lobe, passing just over the base of the tongue and growing slightly towards the glosso-alveolar groove or alveolar ridge, but at a clear distance. The tumor is now removed macroscopically with a safety margin of at least 1.5 to even 2 cm on all sides. The anterior palatal arch, the tonsil and parts of the posterior palatal arch are removed. During removal, the bone on the alveolar ridge is also exposed at the back by pushing away the periosteum here. Caudal resection of parts of the base of the tongue is carried out here at a clear distance. The beginning of the posterior wall of the hypopharynx and posterior wall of the oropharynx is also resected. Due to the growth at one point in depth in the direction of the submandibular gland, the tumor is then resected from the transcervical side as part of the neck dissection. After cutting the digastric muscle, the submandibular gland is mobilized. The hypoglossal nerve is exposed and spared for this purpose. The lingual nerve was already severed during the resection from the enoral side, as it runs too close to the tumor or was infiltrated by the tumor. Glandula submandibularis is now pushed into the oral cavity en bloc with the tumor and attached soft tissue. It can be seen that the tumor was resected macroscopically with a wide safety margin on all sides. Nevertheless, another marginal sample was taken at the alveolar ridge extending to the glossotonsillar groove. Tumor is marked with a thread and sent for frozen section together with the marginal sample. The frozen section shows carcinoma in situ on all sides, partly with transition to microcarcinoma, only in the area of the posterior palatal arch there is no carcinoma in situ. A large strip of mucosa is now removed from the alveolar ridge, whereby the mucosa is removed down to the alveoli. In addition, a large resectate is removed from the caudal pharyngeal wall, as well as a wide resectate from the pharyngeal entrance, vallecula area to the base of the tongue. All resected specimens are sent for re-examination as frozen sections, with the sutures placed away from the tumor. Carcinoma in situ again in almost all specimens. After consultation with the pathologists, this appears to be a field carcinoma. Therefore, only the specimen in the caudal pharyngeal region appears to be free of tumor and no carcinoma in situ is detectable. This is followed by a final marginal sample from the vallecula/base of tongue area, where the sutures are again placed away from the tumor. However, this is no longer a frozen section examination but a final examination. It is no longer possible to take a mucosal sample from the alveolar ridge, as the resection has already reached the beginning of the alveolus. The mucosa is healthy towards the floor of the mouth. R1 affected areas are therefore the dorsal alveolar ridge and the base of the tongue/valley area. Overall tendency towards field carcinomatization after consultation with the pathologist. Neck dissection on the left side (): Injection of 10 ml ultracaine solution, making a skin incision from the mastoid at the anterior margin of the sternocleidomastoid caudally with a slight swing laterally. Expose the platysma. Create a platysma flap anteriorly, expose the sternocleidomastoid. Mobilization of the muscle, sharp dissection in depth up to the plexus branches. The cranial accessorius nerve is exposed. Now follow and mobilize the omohyoid muscle and expose the substructure of the submandibular gland. The gland is now pulled upwards until the digaster muscle is exposed. Exposure of the digaster muscle. Now insert a retractor in the caudal region. Expose the internal jugular vein. Dissect the vein from caudal to cranial, follow the outlets anteriorly, coagulate a small outlet. Now mobilize the neck preparation in level II in the anterior triangle, exposing the hypoglossal nerve and the facial artery. There is bleeding from a small branch of the facial artery, which is ligated. Separation of the anterior triangle up to the omohyoid muscle. Now evacuate level IIa. Pass the neck preparation under the accessorius and dissect caudally via levels III and IV, sparing the plexus branches of the vagus nerve and the internal carotid artery, which is exposed. Finally, check for bloodlessness, which is present. Insertion of a Redon drainage and two-layer wound closure. At the same time, the radial artery graft is lifted from the arm. The extent of the visible tumor was measured to be 8 x 6 cm. A buffer with a final graft size of 12 x 8 cm is also lifted from the forearm. For this purpose, the graft is marked, the graft is cut around and the skin is incised in the proximal forearm area. Exposure of the vein star. The second concomitant vein of the flap stalk has no contact with the superficial system or the venous confluence. The first concomitant vein opens into the venous confluence. Then lift the radialis graft, exposing the brachioradialis muscle of the superficial ramus of the radial nerve, the radial artery and lift the graft from the tendon bed and dissect the pedicle in the usual manner. Deposition of the graft in the usual manner and closure of the forearm with split skin from the thigh. The frozen section still showed carcinoma in situ with microinvasion in the marginal samples, therefore resected 3 more times and the 2nd resection also showed carcinoma in situ with microinvasion, the third resection was taken in the area of the vallecula and sent for final histology. In the end, the resection significantly enlarged the defect so that the graft could only be sutured in under tension and with difficulty. The anastomosis was then performed using the facial artery. The facial artery is altered like a plaque and the endothelium has already detached over a long distance within the vessel. Therefore, 2 suture attempts were necessary to connect the radial artery with the facial artery. Two veins were couplers, one directly from the concomitant vein with an outlet from the internal jugular vein and then two outlets from the venous confluence with two outlets from the facial vein. At the end, insertion of a Redon drainage (Jackson type) and two-layer wound closure and insertion of an 8-gauge tracheostomy tube. Inspection of the oral cavity and the graft. The graft shows a good blood supply (random sample). Prior to the tumor resection, a PEG was inserted using the thread pull-through method without any problems. \ No newline at end of file diff --git a/377/InvasionFront_CD3_block10_x3_y4_patient377_0.json b/377/InvasionFront_CD3_block10_x3_y4_patient377_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a649cb3e573c8850e4d13cd2da3a7b937f5fac97 --- /dev/null +++ b/377/InvasionFront_CD3_block10_x3_y4_patient377_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 15316.9, + "Num Detections": 20807, + "Num Negative": 20129, + "Num Positive": 678, + "Positive %": 3.259, + "Num Positive per mm^2": 258.09 + } +} \ No newline at end of file diff --git a/377/InvasionFront_CD3_block10_x4_y4_patient377_1.json b/377/InvasionFront_CD3_block10_x4_y4_patient377_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b6acdf79e3c6c46873567f59ac6987cfee35cd3 --- /dev/null +++ b/377/InvasionFront_CD3_block10_x4_y4_patient377_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 15566.8, + "Num Detections": 23207, + "Num Negative": 22690, + "Num Positive": 517, + "Positive %": 2.228, + "Num Positive per mm^2": 194.4 + } +} \ No newline at end of file diff --git a/377/InvasionFront_CD8_block10_x3_y4_patient377_0.json b/377/InvasionFront_CD8_block10_x3_y4_patient377_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a5fc2cc0993bc3bb17f0b128465c8aa18bfc95d8 --- /dev/null +++ b/377/InvasionFront_CD8_block10_x3_y4_patient377_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12693.3, + "Centroid Y µm": 15541.8, + "Num Detections": 22329, + "Num Negative": 22038, + "Num Positive": 291, + "Positive %": 1.303, + "Num Positive per mm^2": 109.94 + } +} \ No newline at end of file diff --git a/377/InvasionFront_CD8_block10_x4_y4_patient377_1.json b/377/InvasionFront_CD8_block10_x4_y4_patient377_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e357265bad73cda720129b5ce0ee44906381a28 --- /dev/null +++ b/377/InvasionFront_CD8_block10_x4_y4_patient377_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15366.9, + "Centroid Y µm": 15666.7, + "Num Detections": 24686, + "Num Negative": 24345, + "Num Positive": 341, + "Positive %": 1.381, + "Num Positive per mm^2": 126.21 + } +} \ No newline at end of file diff --git a/377/TumorCenter_CD3_block10_x3_y4_patient377_0.json b/377/TumorCenter_CD3_block10_x3_y4_patient377_0.json new file mode 100644 index 0000000000000000000000000000000000000000..012bfc7c5c34ae7f61b2051900b73599fc9b1b9c --- /dev/null +++ b/377/TumorCenter_CD3_block10_x3_y4_patient377_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 9844.8, + "Num Detections": 3405, + "Num Negative": 2974, + "Num Positive": 431, + "Positive %": 12.66, + "Num Positive per mm^2": 977.06 + } +} \ No newline at end of file diff --git a/377/TumorCenter_CD3_block10_x4_y4_patient377_1.json b/377/TumorCenter_CD3_block10_x4_y4_patient377_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a6c9e9fd7005c74974dfa2a6af8af36fe96d83a5 --- /dev/null +++ b/377/TumorCenter_CD3_block10_x4_y4_patient377_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 9794.8, + "Num Detections": 4677, + "Num Negative": 4383, + "Num Positive": 294, + "Positive %": 6.286, + "Num Positive per mm^2": 487.14 + } +} \ No newline at end of file diff --git a/377/TumorCenter_CD8_block10_x3_y4_patient377_0.json b/377/TumorCenter_CD8_block10_x3_y4_patient377_0.json new file mode 100644 index 0000000000000000000000000000000000000000..61b8b274b809d536f4deaf16d8de782d097075d1 --- /dev/null +++ b/377/TumorCenter_CD8_block10_x3_y4_patient377_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 10544.4, + "Num Detections": 21049, + "Num Negative": 19876, + "Num Positive": 1173, + "Positive %": 5.573, + "Num Positive per mm^2": 519.01 + } +} \ No newline at end of file diff --git a/377/TumorCenter_CD8_block10_x4_y4_patient377_1.json b/377/TumorCenter_CD8_block10_x4_y4_patient377_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9aa11c7dfd657bd64f282b78e087987e8d269fc8 --- /dev/null +++ b/377/TumorCenter_CD8_block10_x4_y4_patient377_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13442.9, + "Centroid Y µm": 10494.4, + "Num Detections": 18780, + "Num Negative": 18142, + "Num Positive": 638, + "Positive %": 3.397, + "Num Positive per mm^2": 296.3 + } +} \ No newline at end of file diff --git a/377/history_text.txt b/377/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..75eea8263bad9c436484c75a1db04d5dc0c1b5f0 --- /dev/null +++ b/377/history_text.txt @@ -0,0 +1 @@ +In the patient, a differentiated squamous cell carcinoma in the right hypopharyngeal region had already been histologically confirmed externally. <2013> the extension was determined. Suspicion of tumor growth towards the cervical vascular sheath. Sonographic and computed tomographic cN0 and cM0 status. In our interdisciplinary tumor conference, primary surgical treatment was recommended; due to the growth, an external approach with flap coverage if necessary was favoured. \ No newline at end of file diff --git a/377/icd_codes.txt b/377/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8942df050249e3880166bd6eaf35efe4c40f2c9 --- /dev/null +++ b/377/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] \ No newline at end of file diff --git a/377/ops_codes.txt b/377/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2d43ff473c08b91543a623b85364ca485dbdcd8b --- /dev/null +++ b/377/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.x0 ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] \ No newline at end of file diff --git a/377/patient_clinical_data.json b/377/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8a0972d819048c336f4f883038e73ae5f0277a08 --- /dev/null +++ b/377/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 64, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/377/patient_pathological_data.json b/377/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e652606f1ac4bceb5b0d279bce8f20d9af2bd5af --- /dev/null +++ b/377/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "377", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 23, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/377/surgery_description.txt b/377/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d0ed6d50bded07b0b817a783b7d41e57cbde9ecf --- /dev/null +++ b/377/surgery_description.txt @@ -0,0 +1 @@ +Transoral partial laser resection, PEG, Neck dissection diff --git a/377/surgery_report.txt b/377/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c1c91f87eb2a8389a8f07e8ef86aaa88c2c9a52a --- /dev/null +++ b/377/surgery_report.txt @@ -0,0 +1 @@ +First, after induction and intubation by the anesthesia colleagues, re-inspection with the Kleinsasser tube. Here, entry with the Kleinsasser tube under dental protection. Inconspicuous oral cavity and oropharynx. As described above, there is an exophytic mass in the area of the right hypopharynx, mainly located in the area of the posterior wall and just reaching the lateral wall in the current status. Otherwise no laryngeal affection. The tip of the piriform sinus as well as the anterior wall and the medial wall are tumor-free, so that the initial description of the tumor must be qualified if the tumor is palpably displaceable. With good displacement, good possibility for laser resection. Therefore resection after adjustment of the tumor, microscopically controlled with the 5 Watt CO2 laser, with adequate safety distance. Regular tissue conditions on all sides, even at depth. No growth towards the vascular nerve sheath. The tumor can now be resected macroscopically and palpatorily in depth and to the side completely in sano. In the area of the mucosal level and the submucosal area, completely forming marginal specimens follow; these are described in the frozen section diagnostics as completely free of dysplasia and tumor. Therefore a clear R0 situation. Careful hemostasis using monopolar coagulation and, if the wound is finally dry, proceed to neck dissection. Neck dissection. First to the right side. Skin incision made at the front edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Dissection of the platysma. Exposure and preservation of the external jugular vein and auricular nerve. Exposure of the sternocleidomastoid muscle, omohyoid muscle. Exposure of the submandibular gland, including the caudal capsule, and exposure of the digastric muscle. Release of the anterior neck preparation while carefully protecting the facial vein, the superior thyroid artery and the cervical artery. In the area of the lateral pharyngeal wall, no evidence of a penetrating defect. Dissection of the internal jugular vein. Clearing of the accessorius triangle while protecting the nerve and clearing of level V while carefully protecting the cervical plexus branches. Final wound irrigation and, if dry and intact, insertion of a 10 Redon drain and careful two-layer wound closure. Then turn to the opposite side. Exactly the same procedure here. The incision is also made on the anterior edge of the sternocleidomastoid muscle. Exposure of the limiting musculature. Expose the submandibular gland, also taking the caudal capsule with it. Evacuation of level II a to V a while sparing the facial vein, the superior thyroid artery, the cervical sinus, the accessorius nerve and the cervical plexus. Followed by wound irrigation. Insertion of a 10-gauge Redon drain and two-layer wound closure. Macroscopic cervical confirmation of cN0 neck status on both sides. Due to the location of the tumor, indicated the placement of a PEG. For this purpose, insertion with the flexible esophagogastroscope under laryngoscopic control. Easy to see through to the stomach. However, computed tomography reveals a suspected thoracic stomach with a clear cranial displacement. Nevertheless, with excellent diaphanoscopy, puncture of the stomach and subsequent insertion of the PEG tube using the usual suture pull-through method was successful. Finally, the findings region is adjusted. This shows dry and slim conditions. Completely slender endolarynx, so that the procedure is terminated at this point. Conclusion: Intraoperative R0-resected cT1 cN0 hypopharyngeal carcinoma on the right. Postoperatively, please abstain from food for 7 days, then carefully and gradually build up the diet and after receiving the definitive histology, presentation at our interdisciplinary tumor conference to discuss adjuvant therapy. \ No newline at end of file diff --git a/378/InvasionFront_CD3_block18_x3_y3_patient378_0.json b/378/InvasionFront_CD3_block18_x3_y3_patient378_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9f57d9040e8b9e444e75e3bf390cf10f2f7d0ee5 --- /dev/null +++ b/378/InvasionFront_CD3_block18_x3_y3_patient378_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11743.8, + "Centroid Y µm": 12093.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/378/InvasionFront_CD3_block18_x4_y3_patient378_1.json b/378/InvasionFront_CD3_block18_x4_y3_patient378_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a20faabb540595f7eaa361a8d77557d9d6ff9110 --- /dev/null +++ b/378/InvasionFront_CD3_block18_x4_y3_patient378_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14442.4, + "Centroid Y µm": 12243.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/378/InvasionFront_CD8_block18_x3_y3_patient378_0.json b/378/InvasionFront_CD8_block18_x3_y3_patient378_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5a652ae3267057bfb99296476228153d9cb36f1e --- /dev/null +++ b/378/InvasionFront_CD8_block18_x3_y3_patient378_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11608.3, + "Centroid Y µm": 15422.9, + "Num Detections": 14234, + "Num Negative": 13001, + "Num Positive": 1233, + "Positive %": 8.662, + "Num Positive per mm^2": 788.55 + } +} \ No newline at end of file diff --git a/378/InvasionFront_CD8_block18_x4_y3_patient378_1.json b/378/InvasionFront_CD8_block18_x4_y3_patient378_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6213d886561d8b31078e33cdd6cb8ab09372b6b8 --- /dev/null +++ b/378/InvasionFront_CD8_block18_x4_y3_patient378_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14008.7, + "Centroid Y µm": 15393.3, + "Num Detections": 20567, + "Num Negative": 18834, + "Num Positive": 1733, + "Positive %": 8.426, + "Num Positive per mm^2": 776.38 + } +} \ No newline at end of file diff --git a/378/TumorCenter_CD3_block18_x3_y3_patient378_0.json b/378/TumorCenter_CD3_block18_x3_y3_patient378_0.json new file mode 100644 index 0000000000000000000000000000000000000000..717cf4d6e61b1617f89db5413ba00371b1e4fe95 --- /dev/null +++ b/378/TumorCenter_CD3_block18_x3_y3_patient378_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.6, + "Centroid Y µm": 7341.1, + "Num Detections": 16022, + "Num Negative": 15533, + "Num Positive": 489, + "Positive %": 3.052, + "Num Positive per mm^2": 213.62 + } +} \ No newline at end of file diff --git a/378/TumorCenter_CD3_block18_x4_y3_patient378_1.json b/378/TumorCenter_CD3_block18_x4_y3_patient378_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a2571fc9bf05db101e469041af9552e3ca25b2c6 --- /dev/null +++ b/378/TumorCenter_CD3_block18_x4_y3_patient378_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13426.8, + "Centroid Y µm": 7364.3, + "Num Detections": 16758, + "Num Negative": 16337, + "Num Positive": 421, + "Positive %": 2.512, + "Num Positive per mm^2": 185.02 + } +} \ No newline at end of file diff --git a/378/TumorCenter_CD8_block18_x3_y3_patient378_0.json b/378/TumorCenter_CD8_block18_x3_y3_patient378_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f1ecf416788992e4d14217fcdd197e3bd8dfc58c --- /dev/null +++ b/378/TumorCenter_CD8_block18_x3_y3_patient378_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 7995.8, + "Num Detections": 17445, + "Num Negative": 16337, + "Num Positive": 1108, + "Positive %": 6.351, + "Num Positive per mm^2": 470.83 + } +} \ No newline at end of file diff --git a/378/TumorCenter_CD8_block18_x4_y3_patient378_1.json b/378/TumorCenter_CD8_block18_x4_y3_patient378_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4f89c14139dfbc19b79311d8e6893b88ac825f4a --- /dev/null +++ b/378/TumorCenter_CD8_block18_x4_y3_patient378_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 8020.8, + "Num Detections": 18652, + "Num Negative": 17526, + "Num Positive": 1126, + "Positive %": 6.037, + "Num Positive per mm^2": 474.07 + } +} \ No newline at end of file diff --git a/378/history_text.txt b/378/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..71adedb179f1d6d1a3e077a4e100c50735b2befc --- /dev/null +++ b/378/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT2 cN0 G2 squamous cell carcinoma of the right glottis and subglottis on the right side with clear involvement of the anterior commissure and slight transition into the left glottis. Thus indication for the above-mentioned measures. \ No newline at end of file diff --git a/378/icd_codes.txt b/378/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a8a126ffdff1d999d25d6524c1ea26483f4d8969 --- /dev/null +++ b/378/icd_codes.txt @@ -0,0 +1 @@ +cT1a glott. Larynx-Ca[C32.0 ] \ No newline at end of file diff --git a/378/ops_codes.txt b/378/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2468436dce26bdc120c9d57400cad62a78162ab --- /dev/null +++ b/378/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/378/patient_clinical_data.json b/378/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c8b2621429320e2a53207438d09fdc4c25b2b3ed --- /dev/null +++ b/378/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/378/patient_pathological_data.json b/378/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0b10b06605892dad357113dd39b23fe63433d173 --- /dev/null +++ b/378/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "378", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/378/surgery_description.txt b/378/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..94c167b266ee59a15261f0143d16f4c31bb21f6a --- /dev/null +++ b/378/surgery_description.txt @@ -0,0 +1 @@ +Partial resection, frontolateral (Leroux-Robert) diff --git a/378/surgery_report.txt b/378/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..4dcdfa213c913229655de7829d8002b6f7a2d7e0 --- /dev/null +++ b/378/surgery_report.txt @@ -0,0 +1 @@ +First induction of anesthesia. Transoral endotracheal intubation by the anesthetist. Positioning of the patient by the surgeon. Laryngoscopy and microlaryngoscopy are performed. This shows an uneven mucosal change, clearly growing in depth, which infiltrates the right vocal fold from posterior to anterior (and caudally in its subglottic slope) and then passes over the anterior commissure to the left side. Due to the clear deep infiltration of the anterior commissure and after demonstration of the findings on , the decision was made to perform a transcervical partial laryngectomy. Removal of the Kleinsasser C-tube and subsequent skin spray disinfection. Application of local anesthesia in a skin fold at the level of the thyroid cartilage. Ablate the skin and cover sterilely. Creation of a skin incision approx. 5 cm long. Cut through the subcutaneous tissue and the platysma. Creation of a subplatysmal flap up to the thyroid incisura cranially and below the cricoid cartilage caudally. Exposure and ligation of the anterior jugular vein. Exposure and transection of the prelaryngeal muscles in the midline. Exposure of the thyroid cartilage, the ligamentum conicum and the cricoid cartilage. Scalpel incision of the perichondrium of the thyroid cartilage. Formation of two laterally pedicled perichondrium lobes. Cutting of the conic ligament. Paramedian thyrotomy on the left using a wheel and entering the laryngeal lumen. Checking the findings from the cranial and caudal side using 30° optics. Subsequent insertion subperichondrally on the right side. Inclusion in the preparation of the inner perichondrium of the thyroid cartilage. Inclusion in the preparation of a part of the sinus morgagni and the subglottic slope of the right vocal fold in order to create a large safety margin. Posteriorly, the vocal process of the arytenoid cartilage is removed together with the preparation. The anterior third of the left vocal fold is then included in the preparation. Removal of marginal samples (right subglottis, right supraglottis, right arytenoid cartilage, right base of the wound, left anterior vocal fold), which are found to be free of tumor and dysplasia by the pathology colleagues. Hemostasis in the area of the tumor resection using bipolar coagulation. Drilling of four holes using a Lindemann reamer on the thyroid cartilage and fitting of a size 16 Keel prosthesis. Suture adaptation of the conic ligament. Creation of a flap. Suture adaptation of the prelaryngeal musculature in the midline. Platysma suture. Single-button skin suture, application of a pressure bandage. Completion of the procedure without complications. Placement of a nasogastric feeding tube through which the patient is to be fed for the next 5 days. Control MLE and, depending on the findings, removal of the cone planned in 6 weeks. \ No newline at end of file diff --git a/379/InvasionFront_CD3_block13_x3_y6_patient379_0.json b/379/InvasionFront_CD3_block13_x3_y6_patient379_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b1cfbab958138505d2a3f1e0d3aeec36ee410461 --- /dev/null +++ b/379/InvasionFront_CD3_block13_x3_y6_patient379_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 14117.5, + "Num Detections": 15108, + "Num Negative": 11342, + "Num Positive": 3766, + "Positive %": 24.93, + "Num Positive per mm^2": 2323.3 + } +} \ No newline at end of file diff --git a/379/InvasionFront_CD3_block13_x4_y6_patient379_1.json b/379/InvasionFront_CD3_block13_x4_y6_patient379_1.json new file mode 100644 index 0000000000000000000000000000000000000000..077bbfc295f54a90dd254ac65e4e80a163aaec62 --- /dev/null +++ b/379/InvasionFront_CD3_block13_x4_y6_patient379_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 14217.5, + "Num Detections": 16617, + "Num Negative": 15091, + "Num Positive": 1526, + "Positive %": 9.183, + "Num Positive per mm^2": 891.64 + } +} \ No newline at end of file diff --git a/379/InvasionFront_CD8_block13_x3_y6_patient379_0.json b/379/InvasionFront_CD8_block13_x3_y6_patient379_0.json new file mode 100644 index 0000000000000000000000000000000000000000..511e656f3602c3995ea494e7e846051a0052d317 --- /dev/null +++ b/379/InvasionFront_CD8_block13_x3_y6_patient379_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12118.6, + "Centroid Y µm": 15716.7, + "Num Detections": 16378, + "Num Negative": 13846, + "Num Positive": 2532, + "Positive %": 15.46, + "Num Positive per mm^2": 1483.9 + } +} \ No newline at end of file diff --git a/379/InvasionFront_CD8_block13_x4_y6_patient379_1.json b/379/InvasionFront_CD8_block13_x4_y6_patient379_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cdb9db118ce2da152e8e475c9996ffeaf8cd9c4f --- /dev/null +++ b/379/InvasionFront_CD8_block13_x4_y6_patient379_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14692.2, + "Centroid Y µm": 15991.5, + "Num Detections": 16491, + "Num Negative": 15219, + "Num Positive": 1272, + "Positive %": 7.713, + "Num Positive per mm^2": 733.21 + } +} \ No newline at end of file diff --git a/379/TumorCenter_CD3_block13_x3_y6_patient379_0.json b/379/TumorCenter_CD3_block13_x3_y6_patient379_0.json new file mode 100644 index 0000000000000000000000000000000000000000..736c7ac5479dce00f00770670a34bfc92bc0002e --- /dev/null +++ b/379/TumorCenter_CD3_block13_x3_y6_patient379_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11968.7, + "Centroid Y µm": 21338.7, + "Num Detections": 11962, + "Num Negative": 8309, + "Num Positive": 3653, + "Positive %": 30.54, + "Num Positive per mm^2": 2906.5 + } +} \ No newline at end of file diff --git a/379/TumorCenter_CD3_block13_x4_y6_patient379_1.json b/379/TumorCenter_CD3_block13_x4_y6_patient379_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b48b619bb0de385b6f59438011283c921b2dcaeb --- /dev/null +++ b/379/TumorCenter_CD3_block13_x4_y6_patient379_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14392.4, + "Centroid Y µm": 21638.5, + "Num Detections": 15657, + "Num Negative": 13537, + "Num Positive": 2120, + "Positive %": 13.54, + "Num Positive per mm^2": 1223.1 + } +} \ No newline at end of file diff --git a/379/TumorCenter_CD8_block13_x3_y6_patient379_0.json b/379/TumorCenter_CD8_block13_x3_y6_patient379_0.json new file mode 100644 index 0000000000000000000000000000000000000000..699b18371b23a357fa3bd03cbd99aedf750be784 --- /dev/null +++ b/379/TumorCenter_CD8_block13_x3_y6_patient379_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11818.7, + "Centroid Y µm": 14992.1, + "Num Detections": 16393, + "Num Negative": 12676, + "Num Positive": 3717, + "Positive %": 22.67, + "Num Positive per mm^2": 2266.8 + } +} \ No newline at end of file diff --git a/379/TumorCenter_CD8_block13_x4_y6_patient379_1.json b/379/TumorCenter_CD8_block13_x4_y6_patient379_1.json new file mode 100644 index 0000000000000000000000000000000000000000..256dcfce8daa6a253adc90a8f1b0d845d50bbc78 --- /dev/null +++ b/379/TumorCenter_CD8_block13_x4_y6_patient379_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14167.5, + "Centroid Y µm": 14692.2, + "Num Detections": 16501, + "Num Negative": 14787, + "Num Positive": 1714, + "Positive %": 10.39, + "Num Positive per mm^2": 1051.6 + } +} \ No newline at end of file diff --git a/379/history_text.txt b/379/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/379/icd_codes.txt b/379/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..83f2ebf0cf526ba28feb4b25fd830bfc89756e82 --- /dev/null +++ b/379/icd_codes.txt @@ -0,0 +1 @@ +Karzinom aryepiglottische Falte hypopharyngeale Seite[C13.1 L] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/379/ops_codes.txt b/379/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9a62bcd5ec1737e42e35c7c1254b352536cd57f4 --- /dev/null +++ b/379/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Permanente Tracheotomie[5-312.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 R] Einlegen einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/379/patient_clinical_data.json b/379/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..34f19a5056f6c7188f2c54425ce42dac89430b55 --- /dev/null +++ b/379/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 60, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/379/patient_pathological_data.json b/379/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4048638982d57869d71c009f5a7077c238190ad7 --- /dev/null +++ b/379/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "379", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 52.0, + "number_of_resected_lymph_nodes": 68, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/379/surgery_description.txt b/379/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f9c91a39d4d9015dc5fa86ec65d2ebeabc6d86d6 --- /dev/null +++ b/379/surgery_description.txt @@ -0,0 +1 @@ +LE (Laryngo-esophagectomy), Partial pharyngeal resection, Bilateral neck dissection, Tracheotomy, Voice prosthesis diff --git a/379/surgery_report.txt b/379/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..adef2c9b9bdf1401c81dc1ede48229b2fac7a63e --- /dev/null +++ b/379/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, a diagnostic panendoscopy is performed. Here, a tumor originating from the left piriform sinus, which also affects the lateral larynx, can be seen when the larynx is adjusted. Tumor resection alone without removal of the larynx would result in a hypopharyngeal defect that would have to be reconstructed, whereby the reconstruction would extend to the entrance to the larynx with corresponding negative consequences for swallowing ability. The decision was therefore made to perform a total laryngectomy including the left piriform sinus. Subsequent sterile washing and draping. Creation of the apron flap and preparation upwards. Perform the tracheostomy in the area of the 3rd tracheal clasp. Then start with the neck dissection on the left side. The large metastases can be seen here, which safely infiltrate the sternocleidomastoid muscle and the internal jugular vein. The lymph node package is first removed from the cranial side along the anterior belly of the digastric muscle. The resection also includes the caudal part of the parotid gland after exposure of the ramus marginalis mandibulae at its crossing point via the facial vessels. This allows the tumor block to be initially mobilized from the cranial side. Expose the very small internal jugular vein at the base of the skull. Then remove the sternocleidomastoid muscle from its origin at the mastoid. Now skeletonize the cervical vascular nerve sheath starting caudally. The entire length of the common carotid artery, including the carotid bifurcation and the internal carotid artery, can be exposed and mobilized from the tumor masses. The facial artery and the pharyngeal artery must be removed for tumor removal. The vagus nerve remains intact and runs slightly dorsal to the artery. The internal jugular vein is then also exposed caudally, which is removed just above its inflow into the subclavian vein. Resection of the lymph node conglomerate including the muscle then begins. The accessory nerve cannot be saved either. However, the hypoglossal nerve can still be dissected free in a healthy layer and left in place. The lymph node package is thus developed successively from cranial to caudal. Behind the large, easily palpable tumor masses, smaller, coarse lymph node metastases are repeatedly palpated, all of which are also removed. The cervical plexus is completely resected. The phrenic nerve is then exposed and preserved. The resection extends dorsally almost to the scapula, exposing and preserving the brachial plexus. Caudally, the metastasis extends below the clavicle and is dissected free along the subclavian vein. The thoracic duct on the right side at the caudal pole of the huge metastasis is also exposed and opened. This is then ligated at both ends so that there is no more intraoperative chyle leakage. The remaining lymph node metastases that have submerged behind the clavicles are then also removed en bloc, so that a huge lymph node conglomerate is removed from the left neck together with the surrounding fatty tissue. Subsequent removal of the constrictor pharyngis muscle from the lateral thyroid cartilage. Push the thyroid gland laterally, pass under the isthmus and ligate it. Separation of the hyoid bone from its cranial muscle attachments. Minor release of the piriform sinus on the left side. Subsequent evacuation of regions Ia and Ib, including the submandibular gland on the left side. Then transition to neck dissection on the opposite side. Here too, regions I-V are evacuated while preserving all non-lymphatic structures. The thyroid gland is then detached from the larynx and lateralized. Separation of the ansa of the constrictor pharyngis muscle from the laryngeal skeleton and complete release of the piriform sinus. Now remove the larynx caudally under the cricoid cartilage and dissect a caudally pedicled mucosal flap from the inside of the cricoid cartilage plate. This is then used in the usual way to cover the tracheal chimney above. Now dissect the lingual side of the epiglottis up to its upper edge. There, open the pharynx and release the larynx, initially on the right side along the epiglottis and the aryepiglottic fold. This provides an increasing view of the tumor of the left piriform sinus. This is then resected at a safety distance of 1.5 cm together with the laryngeal preparation so that the larynx can finally be completely removed. Removal of frozen section histologies around the now existing hypopharyngeal defect. These all proved to be tumor-free. The myotomy of the constrictor pharyngeal muscle is then performed. Implantation of the voice prosthesis through a Blom-Singer puncture. Suturing of the neopharynx with a continuous Conley suture and a second layer of single button sutures. Placement of Redon suction drains on both sides. Folding back the apron flap and completing the mucocutaneous anastomosis of the tracheostoma. Sterile wound dressing. End of the operation, handover of the patient to anesthesia. Conclusion: Total laryngectomy with partial pharyngectomy for hypopharyngeal carcinoma on the left side. Intraoperative extensive left cervical lymph node metastases, which led to a radical neck dissection on the left side, functional neck dissection of regions I-V on the right, primary voice rehabilitation by Blom-Singer puncture. Implantation of a voice prosthesis after myotomy of the constrictor pharyngis muscle and installation of a tracheal chimney according to Herrmann. \ No newline at end of file diff --git a/380/InvasionFront_CD3_block14_x3_y4_patient380_0.json b/380/InvasionFront_CD3_block14_x3_y4_patient380_0.json new file mode 100644 index 0000000000000000000000000000000000000000..553cb1cd7d86043dbdada0660241b2e7cbfdd6c9 --- /dev/null +++ b/380/InvasionFront_CD3_block14_x3_y4_patient380_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12143.6, + "Centroid Y µm": 13867.7, + "Num Detections": 21421, + "Num Negative": 19778, + "Num Positive": 1643, + "Positive %": 7.67, + "Num Positive per mm^2": 638.31 + } +} \ No newline at end of file diff --git a/380/InvasionFront_CD3_block14_x4_y4_patient380_1.json b/380/InvasionFront_CD3_block14_x4_y4_patient380_1.json new file mode 100644 index 0000000000000000000000000000000000000000..95d06714ecf265afe6a72babf66c8ffef79a0c3b --- /dev/null +++ b/380/InvasionFront_CD3_block14_x4_y4_patient380_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14792.2, + "Centroid Y µm": 13892.6, + "Num Detections": 20698, + "Num Negative": 19316, + "Num Positive": 1382, + "Positive %": 6.677, + "Num Positive per mm^2": 561.72 + } +} \ No newline at end of file diff --git a/380/InvasionFront_CD8_block14_x3_y4_patient380_0.json b/380/InvasionFront_CD8_block14_x3_y4_patient380_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89185039861afa5ac7fb88c594c57c7cb9a1c147 --- /dev/null +++ b/380/InvasionFront_CD8_block14_x3_y4_patient380_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12018.6, + "Centroid Y µm": 9894.8, + "Num Detections": 22307, + "Num Negative": 20467, + "Num Positive": 1840, + "Positive %": 8.249, + "Num Positive per mm^2": 728.25 + } +} \ No newline at end of file diff --git a/380/InvasionFront_CD8_block14_x4_y4_patient380_1.json b/380/InvasionFront_CD8_block14_x4_y4_patient380_1.json new file mode 100644 index 0000000000000000000000000000000000000000..915b4544288524eb41c38536426bfb21bb8a46a2 --- /dev/null +++ b/380/InvasionFront_CD8_block14_x4_y4_patient380_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14617.3, + "Centroid Y µm": 9819.8, + "Num Detections": 21374, + "Num Negative": 19473, + "Num Positive": 1901, + "Positive %": 8.894, + "Num Positive per mm^2": 773.74 + } +} \ No newline at end of file diff --git a/380/TumorCenter_CD3_block14_x3_y4_patient380_0.json b/380/TumorCenter_CD3_block14_x3_y4_patient380_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ba33f06e48495b150d94b79aba874c79c5d345e --- /dev/null +++ b/380/TumorCenter_CD3_block14_x3_y4_patient380_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11893.7, + "Centroid Y µm": 10394.5, + "Num Detections": 19874, + "Num Negative": 16680, + "Num Positive": 3194, + "Positive %": 16.07, + "Num Positive per mm^2": 1251.1 + } +} \ No newline at end of file diff --git a/380/TumorCenter_CD3_block14_x4_y4_patient380_1.json b/380/TumorCenter_CD3_block14_x4_y4_patient380_1.json new file mode 100644 index 0000000000000000000000000000000000000000..14577db0aaab7456feec8889f878fcebd5cc4277 --- /dev/null +++ b/380/TumorCenter_CD3_block14_x4_y4_patient380_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14467.3, + "Centroid Y µm": 10594.4, + "Num Detections": 13123, + "Num Negative": 12712, + "Num Positive": 411, + "Positive %": 3.132, + "Num Positive per mm^2": 161.01 + } +} \ No newline at end of file diff --git a/380/TumorCenter_CD8_block14_x3_y4_patient380_0.json b/380/TumorCenter_CD8_block14_x3_y4_patient380_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c279226ac011b5e0f2941417bcf00b268559139e --- /dev/null +++ b/380/TumorCenter_CD8_block14_x3_y4_patient380_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 10694.3, + "Num Detections": 21323, + "Num Negative": 19139, + "Num Positive": 2184, + "Positive %": 10.24, + "Num Positive per mm^2": 865.61 + } +} \ No newline at end of file diff --git a/380/TumorCenter_CD8_block14_x4_y4_patient380_1.json b/380/TumorCenter_CD8_block14_x4_y4_patient380_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4a53799336c7b67dafe439c8a2352518114c38a5 --- /dev/null +++ b/380/TumorCenter_CD8_block14_x4_y4_patient380_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 10794.3, + "Num Detections": 20707, + "Num Negative": 19508, + "Num Positive": 1199, + "Positive %": 5.79, + "Num Positive per mm^2": 475.08 + } +} \ No newline at end of file diff --git a/380/history_text.txt b/380/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8eba6415667fbcd91683c364074fd5fcfa6a7e60 --- /dev/null +++ b/380/history_text.txt @@ -0,0 +1 @@ +The patient has an externally histologically confirmed, moderately differentiated squamous cell carcinoma of the tongue between the anterior and middle third of the left edge of the tongue. \ No newline at end of file diff --git a/380/icd_codes.txt b/380/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/380/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/380/ops_codes.txt b/380/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c9f647a3f2e9e6778c5389c91bf06db04b23efa9 --- /dev/null +++ b/380/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] \ No newline at end of file diff --git a/380/patient_clinical_data.json b/380/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f00073079811d9d2411b222afe726f740ab6eb04 --- /dev/null +++ b/380/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 43, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/380/patient_pathological_data.json b/380/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4f98ef12a5d30052650ed01118dfc1036462b164 --- /dev/null +++ b/380/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "380", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/380/surgery_description.txt b/380/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fd7b8d535157b7de19a82fd7258f302c34f9962 --- /dev/null +++ b/380/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Excisional biopsy diff --git a/380/surgery_report.txt b/380/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..211df244658718f6c2958d05cc47ce20720e1ac3 --- /dev/null +++ b/380/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then entry with the 0° scope and inspection of the trachea and glottic plane, no abnormalities here. Next, the flexible oesophagoscope was used to view the trachea and glottis, with no abnormalities on either side. Next, the pharynx and larynx are inspected with the small bore tube. No abnormalities here either. Then insertion of the covered mouth guard without spandex and inspection of the oral cavity. In the oral cavity, the tongue margin carcinoma described above and a leukoplakia in the anterior part of the anterior floor of the mouth on the left side were found. First, the leukoplakia is removed and then the tumor is palpated again. The tumor is relatively superficial overall, but has palpable tumor cones into the tongue. Then snare the tongue and start resecting the tumor using a monopolar needle, safety distance 1.5 cm. Then careful resection using a monopolar needle or bipolar forceps and scissors. The specimen is removed and placed on cork and sent for final histology. Bleeding from the depths is stopped and the anterior part of the resection cavity is sutured so that the tip of the tongue does not gape open. Wait for the histology. If non-in-sano, please resect. Otherwise, present the patient to the tumor conference. \ No newline at end of file diff --git a/381/InvasionFront_CD3_block20_x5_y11_patient381_0.json b/381/InvasionFront_CD3_block20_x5_y11_patient381_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e96ea8ec90ab59a8cd13765a02fa01e021301bfa --- /dev/null +++ b/381/InvasionFront_CD3_block20_x5_y11_patient381_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16016.5, + "Centroid Y µm": 27485.4, + "Num Detections": 26197, + "Num Negative": 24650, + "Num Positive": 1547, + "Positive %": 5.905, + "Num Positive per mm^2": 538.87 + } +} \ No newline at end of file diff --git a/381/InvasionFront_CD3_block20_x6_y11_patient381_1.json b/381/InvasionFront_CD3_block20_x6_y11_patient381_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e30e3fc80cc346e3798839a363b26be8b395537 --- /dev/null +++ b/381/InvasionFront_CD3_block20_x6_y11_patient381_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18565.2, + "Centroid Y µm": 27685.3, + "Num Detections": 22860, + "Num Negative": 21207, + "Num Positive": 1653, + "Positive %": 7.231, + "Num Positive per mm^2": 614.36 + } +} \ No newline at end of file diff --git a/381/InvasionFront_CD8_block20_x5_y10_patient381_0.json b/381/InvasionFront_CD8_block20_x5_y10_patient381_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a179901df5452a0c07a99a10a18185c0cb69fc63 --- /dev/null +++ b/381/InvasionFront_CD8_block20_x5_y10_patient381_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 24861.8, + "Num Detections": 4705, + "Num Negative": 4686, + "Num Positive": 19, + "Positive %": 0.4038, + "Num Positive per mm^2": 34.38 + } +} \ No newline at end of file diff --git a/381/InvasionFront_CD8_block20_x6_y10_patient381_1.json b/381/InvasionFront_CD8_block20_x6_y10_patient381_1.json new file mode 100644 index 0000000000000000000000000000000000000000..82869ab3324a4429d4e3d4bd49f2c0c353bb5298 --- /dev/null +++ b/381/InvasionFront_CD8_block20_x6_y10_patient381_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19852.0, + "Centroid Y µm": 24799.4, + "Num Detections": 7269, + "Num Negative": 7211, + "Num Positive": 58, + "Positive %": 0.7979, + "Num Positive per mm^2": 69.94 + } +} \ No newline at end of file diff --git a/381/TumorCenter_CD3_block20_x5_y10_patient381_0.json b/381/TumorCenter_CD3_block20_x5_y10_patient381_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d9a84c7e3808e5c573530dd8abf7901b2b9060e1 --- /dev/null +++ b/381/TumorCenter_CD3_block20_x5_y10_patient381_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16155.5, + "Centroid Y µm": 24005.6, + "Num Detections": 18805, + "Num Negative": 18558, + "Num Positive": 247, + "Positive %": 1.313, + "Num Positive per mm^2": 110.79 + } +} \ No newline at end of file diff --git a/381/TumorCenter_CD3_block20_x6_y10_patient381_1.json b/381/TumorCenter_CD3_block20_x6_y10_patient381_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1fc223e64a2b39f31aa242a69cf33b915645de95 --- /dev/null +++ b/381/TumorCenter_CD3_block20_x6_y10_patient381_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18672.9, + "Centroid Y µm": 23999.7, + "Num Detections": 14677, + "Num Negative": 14606, + "Num Positive": 71, + "Positive %": 0.4838, + "Num Positive per mm^2": 35.09 + } +} \ No newline at end of file diff --git a/381/TumorCenter_CD8_block20_x5_y10_patient381_0.json b/381/TumorCenter_CD8_block20_x5_y10_patient381_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4a5ce4398bb9d7ecc623072b185c1d1f06da5541 --- /dev/null +++ b/381/TumorCenter_CD8_block20_x5_y10_patient381_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 24961.8, + "Num Detections": 9852, + "Num Negative": 9738, + "Num Positive": 114, + "Positive %": 1.157, + "Num Positive per mm^2": 104.52 + } +} \ No newline at end of file diff --git a/381/TumorCenter_CD8_block20_x6_y10_patient381_1.json b/381/TumorCenter_CD8_block20_x6_y10_patient381_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4bcbb0ce20bc4ea3fabf05e29894751fe61f115c --- /dev/null +++ b/381/TumorCenter_CD8_block20_x6_y10_patient381_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18865.0, + "Centroid Y µm": 24736.9, + "Num Detections": 21766, + "Num Negative": 21694, + "Num Positive": 72, + "Positive %": 0.3308, + "Num Positive per mm^2": 32.84 + } +} \ No newline at end of file diff --git a/381/history_text.txt b/381/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/381/icd_codes.txt b/381/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..cd06ea350eb4d404744d2f0732e3c094787b00de --- /dev/null +++ b/381/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Subglottisches Karzinom[C32.2 ] \ No newline at end of file diff --git a/381/ops_codes.txt b/381/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3c2a95e3edcc6e6faaea088b6241e40f38dd04f2 --- /dev/null +++ b/381/ops_codes.txt @@ -0,0 +1 @@ +Sonstige einfache Laryngektomie[5-303.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] Tracheaplastik sonstige[5-316.5x ] Permanente Retracheotomie[5-312.1 ] PEG-Sonde Anlage[5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/381/patient_clinical_data.json b/381/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2a36013cf7e3d9a2ec471b62e53e800f8e326855 --- /dev/null +++ b/381/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 58, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/381/patient_pathological_data.json b/381/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..51f0c23bfedbe3e1bb0fdb5bfa2f72a721466d66 --- /dev/null +++ b/381/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "381", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 48, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/381/surgery_description.txt b/381/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bb0bd1a1201eee5c4987929fcb41acc71b3734b0 --- /dev/null +++ b/381/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, PEG placement diff --git a/381/surgery_report.txt b/381/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..550384f3aae0c93b5e87e6682e0c08fb9f0affff --- /dev/null +++ b/381/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthetist. Creation of an apron flap in the usual manner, then start with neck dissection on both sides, initially on the right side. Visualization of the sternocleidomastoid muscle anterior border, the omohyoid muscle, then the submandibular gland. Exposure of the accessorius nerve, the internal jugular vein, clearing of levels II, III, IV and V. Turning to the opposite side. Analogous procedure here. Enlarged lymph nodes can be seen on both sides. Then locate the hyoid bone, expose the hyoid bone. Release the hyoid muscles with the monopolar knife. Then skeletonization of the larynx, initially on the right side, exposing the posterior horn. Then release and dissection of the laryngeal musculature. Analogous procedure on the opposite side. Removal of the periosteum and removal and release of the piriform sinus. Exposure and release of the thyroid gland. Then perform a small pharyngotomy and pull out the epiglottis. Incision of the mucosa on both sides of the epiglottis along the aryepiglottic fold and behind the arytenoid region. Then release the entire larynx so that it is only attached to the stoma stump. Now call in who mobilizes the trachea, pulls it upwards, removes the paratracheal and mediastinal lymph nodes and takes a marginal sample from the upper remaining tracheal clamps and sends it to the frozen section marked with sutures. The larynx is removed and also sent to the frozen section marked with sutures. The pathologist can no longer see any carcinoma in the marginal area. The trachea is first epithlized with the skin at the anterior margin. Then turn to the pharynx and begin with the pharyngeal suture in the usual 3-layered manner. First place the marking and corner sutures in the upper and lower area. Perform the first pharyngeal suture inverted. Then transfer of the 2nd pharyngeal suture and then suturing of the 3rd layer, which is formed by the constrictor pharyngis. Insertion of Redon drainage tubes and refixation of the apron flap in two layers and completion of the tracheostoma. Insertion of a 10 mm tracheostomy tube. Now clearing of neck level VI. At the very beginning of the operation, a PEG was placed in the usual manner using the suture pull-through method. Conclusion: Please continue postoperative antibiotics for 24 hours. Do not reclinate the head for a week and on the 10th day, X-ray broad swallow and removal of the nasogastric tube if there is no fistula. \ No newline at end of file diff --git a/382/InvasionFront_CD3_block2_x5_y8_patient382_0.json b/382/InvasionFront_CD3_block2_x5_y8_patient382_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a4d898fbea342498df30e272fc3058de32a638a --- /dev/null +++ b/382/InvasionFront_CD3_block2_x5_y8_patient382_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 33482.3, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/InvasionFront_CD3_block2_x6_y8_patient382_1.json b/382/InvasionFront_CD3_block2_x6_y8_patient382_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad975b6326dc525af0a8f97b4b2993944442fb6e --- /dev/null +++ b/382/InvasionFront_CD3_block2_x6_y8_patient382_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21238.8, + "Centroid Y µm": 33557.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/InvasionFront_CD8_block2_x5_y8_patient382_0.json b/382/InvasionFront_CD8_block2_x5_y8_patient382_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4501e09ea4d195c7e1298482ef03aa27bf6a36fb --- /dev/null +++ b/382/InvasionFront_CD8_block2_x5_y8_patient382_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17315.8, + "Centroid Y µm": 21188.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/InvasionFront_CD8_block2_x6_y8_patient382_1.json b/382/InvasionFront_CD8_block2_x6_y8_patient382_1.json new file mode 100644 index 0000000000000000000000000000000000000000..56093f1b0c7dd7af894ae30040b9488c685c3f2b --- /dev/null +++ b/382/InvasionFront_CD8_block2_x6_y8_patient382_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19939.4, + "Centroid Y µm": 21288.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/TumorCenter_CD3_block2_x5_y8_patient382_0.json b/382/TumorCenter_CD3_block2_x5_y8_patient382_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2a2533942d41c9828280e1fbcc0302b46b556741 --- /dev/null +++ b/382/TumorCenter_CD3_block2_x5_y8_patient382_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16066.5, + "Centroid Y µm": 19764.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/TumorCenter_CD3_block2_x6_y8_patient382_1.json b/382/TumorCenter_CD3_block2_x6_y8_patient382_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7ea3493afe7adec608b6f1366b53ff65be5e68b0 --- /dev/null +++ b/382/TumorCenter_CD3_block2_x6_y8_patient382_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18590.2, + "Centroid Y µm": 19889.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/TumorCenter_CD8_block2_x5_y8_patient382_0.json b/382/TumorCenter_CD8_block2_x5_y8_patient382_0.json new file mode 100644 index 0000000000000000000000000000000000000000..394f9e24cae38142a1b3514c1cfa99cd9963b02c --- /dev/null +++ b/382/TumorCenter_CD8_block2_x5_y8_patient382_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18215.4, + "Centroid Y µm": 19539.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/TumorCenter_CD8_block2_x6_y8_patient382_1.json b/382/TumorCenter_CD8_block2_x6_y8_patient382_1.json new file mode 100644 index 0000000000000000000000000000000000000000..154be69b04e82d86997b3b73f6d847d1aa644f76 --- /dev/null +++ b/382/TumorCenter_CD8_block2_x6_y8_patient382_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20739.0, + "Centroid Y µm": 19489.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/382/history_text.txt b/382/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..b1a2d9c953865ce9ef38170a5b8bcd7a8bb7677c --- /dev/null +++ b/382/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed oropharyngeal carcinoma on the left. This is located at the posterior base of the tongue, base of the tongue, glossoalveolar groove and tonsil lobe. Therefore, the above mentioned surgery is indicated. Squamous cell carcinoma G3. \ No newline at end of file diff --git a/382/icd_codes.txt b/382/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adc050c8f628f1e558c676f540ed678cb6876eb8 --- /dev/null +++ b/382/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/382/ops_codes.txt b/382/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..07bc8807fb79acffd3495f03c964d3c8a071db13 --- /dev/null +++ b/382/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroduodenoskopie bei normalem Situs[1-632.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Partielle Glossektomie durch Pharyngotomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.22 ] Resektion Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Permanente Tracheotomie[5-312.0 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme freier Radialis-Lappen[5-858.23 L] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/382/patient_clinical_data.json b/382/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..556185392894c8da134a772251dfe8998d38249e --- /dev/null +++ b/382/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 55, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/382/patient_pathological_data.json b/382/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..593b586e5c5ff0620f5165de6ce228790d581f7a --- /dev/null +++ b/382/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "382", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/382/surgery_description.txt b/382/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..29d6b9cde2ce5bc98d4a18879c227d78367bdafe --- /dev/null +++ b/382/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Neck dissection, Defect coverage, Free flap (Radial), Tracheostomy creation, PEG placement diff --git a/382/surgery_report.txt b/382/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..61a92ccd7b5c9c053ed832b8c10e6b97966a4e7d --- /dev/null +++ b/382/surgery_report.txt @@ -0,0 +1 @@ +First pharyngoscopy and laryngoscopy: The exophytic tumor is seen, which is located at the posterior edge of the tongue, infiltrates the base of the tongue and extends via the glossoalveolar groove into the tonsillar lobe in the anterior region. This confirms the spread of the tumor and the indication for resection, with flap coverage if necessary. This is followed by transoral resection of the tumor, taking into account the macroscopically visible borders and also the palpatorily recognizable borders. Incision around the tumor with a safety margin of 1 to 1.5 cm on all sides. The posterior area of the tongue up to the middle, including the base of the tongue, the mucosa up to the tonsil lobe over the glossotonsillar groove, the anterior area of the palatal arch. The resection extends caudally to the entrance to the hypopharynx. The preparation is thread-marked and sent for frozen section examination. No evidence of tumor in the entire margin of the specimen, even basally, thus R0 resection. Due to the extent of the defect, flap coverage is indicated in any case. The lingual nerve had to be sharply dissected away from the tumor. The PEG is now placed: pre-splinting through the esophagus into the stomach. Here, after establishing spontaneous diaphanoscopy, insertion of a 15 mm abdominal wall tube without complications. Fixation to the abdominal wall in the typical manner. Subsequent repositioning for neck dissection: skin disinfection and injection of a total of 10 ml Ultracaine 1% with adrenaline into both sides of the neck. Sterile draping. Skin incision first on the left in the typical manner. Depiction of the sternocleidomastoid muscle. Depiction of the omohyoid muscle. A lymph node conglomerate can be seen cranially, which infiltrates the sternocleidomastoid muscle, which is therefore also resected cranially. The digastric muscle is also resected as it is also included in the conglomerate. Spatial mass or lymph node conglomerate also infiltrates the internal jugular vein in the cranial region and the accessorius nerve, both of which must be resected. The internal and external carotid arteries as well as the superior thyroid artery, facial artery and lingual artery can be visualized and preserved. The vagus nerve and hypoglossal nerve, which can be dissected away from the tumor conglomerate, can also be preserved. This results in the removal of level II to V with exposure of the branches of the cervical plexus. The submandibular gland is also removed. A wide tunnel is then created enorally to allow the pedicle to pass through. Neck dissection on the right side. Skin incision along the anterior border of the sternocleidomastoid muscle. Exposure and ligation of the external jugular vein. Exposure and sparing of the auricular nerve. Exposure of the digaster muscle and the cranial accessorius nerve as well as the caudal omohyoid muscle. Exposure of the capsule of the submandibular gland and the hypoglossal nerve. Subsequent exposure of the internal jugular vein from caudal to cranial and complete dissection of the cervical vascular sheath from the multiple suspected metastases in the right anterior neck preparation, particularly in levels II and III. Repeated hemostasis using bipolar coagulation. The multiple cervical metastases on the right side were completely removed while sparing the plexus branches, the accessorius nerve and the hypoglossal nerve. Dry conditions. A complete removal of levels I b, II, III, IV and V was performed, leaving the submandibular gland intact. Wound irrigation with hydrogen peroxide and Ringer's solution. Insertion of a 10-gauge Redon drain and two-layer wound closure. Now proceed to tracheotomy: skin incision a total of 5 cm horizontally below the cricoid cartilage and sharp cutting of the skin and subcutaneous tissue using a 15 mm scalpel. Further dissection in depth using pointed scissors. Jugularis anterior is identified, cut and ligated, no bleeding. Now locate the anterior neck muscles and cut through the linea alba. The musculature is pushed to the side. Further dissection in depth with identification of the thyroid gland and thyroid capsule. The isthmus is small, the gland is also relatively small. Bipolar coagulation of the isthmus and transection of the isthmus. Now identification of the 2nd and 3rd tracheal ring. Creation of a Björk flap, for which both thyroid lobes are bluntly pushed aside and the trachea is opened using pointed scissors. Targeted bipolar coagulation. Now 3 sutures are placed caudally using Ethibond and 3 sutures cranially to ensure sufficient epithelialization. Suturing is performed without any problems. Skin suture with 4-0 Ethilon, 8-gauge cannula is inserted without any problems. Change of cannula on the 5th postoperative day and suture removal between the 7th and 10th postoperative day. Then elevation of the radial flap from the left forearm: After measuring the defect, a flap, length 10 cm, width 6 ˝ cm, is recorded according to the three-dimensional configuration. Subsequently, first ulnar subfascial elevation of the flap. Then extension of the incision curved into the olecranon. Visualization of the surface vein system with connection to the flap pedicle. Subsequent radial subfascial elevation of the flap. Exposure of the lateral antebrachial cutaneous nerve and preservation of this as far as possible. Caudal exposure of the radial artery, which is first clamped. First expose the pedicle up to the elbow. Dissection of the pedicle also from the brachioradialis muscle distally. Then cut the radial artery and treat it using 4-0 prolene stitches. Hand always supplied with 98-100% blood after clamping of the radial artery. Subsequent lifting of the flap. Outgoing vessels are bipolarly coagulated or clipped. A total of 2 branches of the cephalic vein and a confluent vein as well as the radial artery can be dissected in the crook of the elbow. The flap is then removed. The veins are ligated or clipped. The artery is stitched with 6-0 Vascufil sutures. Flush the flap with heparin solution. The flap is then inserted into the defect and the stalk is passed through the tunnel. Suturing of the flap, initially with sutures. The flap can then be sutured into the ............................... defect, covering the entire area. The facial artery is prepared as a vascular connection. Likewise a vein that emerges from the stump of the internal jugular vein and the external jugular vein. First arterial anastomosis between the facial artery and radial artery. After opening the clamps, good arterial flow, good venous return. After conditioning the veins, a portion of the cephalic vein is first anastomosed with the external jugular vein using a 2.5 mm coupler. After opening the clamps, good venous flow, positive smear phenomenon. The other outgoing vein from the external jugular vein is lipped. The 2nd vein from the cephalic vein is also clipped. The confluence is prepared and anastomosed with the outlet from the internal jugular vein after conditioning the veins using a 2.0 coupler. After opening the clamps, good venous return, positive smear phenomenon. Subsequent careful hemostasis and irrigation of the wound area. Wound closure on the right with insertion of a Redon drain on the left and placement of 2 flaps. Insertion of an 8 mm tracheal cannula and suturing of this. The skin on the forearm is primarily closed cranially and split skin taken from the thigh is sutured caudally. Mepilex is then applied and a loose pressure bandage is applied using absorbent cotton. A Kramer splint is then applied and fixed in place with an elastic bandage. Attachment of the arm. The wound on the thigh is covered with a Mepilex dressing. The procedure is completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue antibiotics, which were started with Unacid, intraoperatively for 1 week. Please continue heparin perfusor, which was started intraoperatively, at 500 units per hour for 5 days. Check the vitality of the flap clinically and by Doppler. Left cervical suture marking for this purpose. Feeding via the inserted PEG tube for 10 days, then gruel or, if necessary, diet build-up. Overall cT2 to 3 oropharyngeal carcinoma on the left with cN2c status. Postoperative presentation at the interdisciplinary tumor conference after receipt of the final histology. \ No newline at end of file diff --git a/383/InvasionFront_CD3_block3_x5_y11_patient383_0.json b/383/InvasionFront_CD3_block3_x5_y11_patient383_0.json new file mode 100644 index 0000000000000000000000000000000000000000..75793c5eda850c42687373efe0f6d167766baf21 --- /dev/null +++ b/383/InvasionFront_CD3_block3_x5_y11_patient383_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16099.8, + "Centroid Y µm": 34477.1, + "Num Detections": 20606, + "Num Negative": 18231, + "Num Positive": 2375, + "Positive %": 11.53, + "Num Positive per mm^2": 963.95 + } +} \ No newline at end of file diff --git a/383/InvasionFront_CD3_block3_x6_y11_patient383_1.json b/383/InvasionFront_CD3_block3_x6_y11_patient383_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9e25e3aa140324f8ce73e6ac6ea9d70b61c850e0 --- /dev/null +++ b/383/InvasionFront_CD3_block3_x6_y11_patient383_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18799.2, + "Centroid Y µm": 34705.5, + "Num Detections": 22149, + "Num Negative": 17192, + "Num Positive": 4957, + "Positive %": 22.38, + "Num Positive per mm^2": 2019.0 + } +} \ No newline at end of file diff --git a/383/InvasionFront_CD8_block3_x5_y9_patient383_0.json b/383/InvasionFront_CD8_block3_x5_y9_patient383_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ec67731e84a8be2cf81284d4dc60a1a05768af16 --- /dev/null +++ b/383/InvasionFront_CD8_block3_x5_y9_patient383_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17440.8, + "Centroid Y µm": 22313.2, + "Num Detections": 17769, + "Num Negative": 17703, + "Num Positive": 66, + "Positive %": 0.3714, + "Num Positive per mm^2": 29.83 + } +} \ No newline at end of file diff --git a/383/InvasionFront_CD8_block3_x6_y9_patient383_1.json b/383/InvasionFront_CD8_block3_x6_y9_patient383_1.json new file mode 100644 index 0000000000000000000000000000000000000000..94101fcbf04cb119371f8c49617f0b2cd1a650f3 --- /dev/null +++ b/383/InvasionFront_CD8_block3_x6_y9_patient383_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20214.3, + "Centroid Y µm": 22288.2, + "Num Detections": 16718, + "Num Negative": 16438, + "Num Positive": 280, + "Positive %": 1.675, + "Num Positive per mm^2": 125.2 + } +} \ No newline at end of file diff --git a/383/TumorCenter_CD3_block3_x5_y9_patient383_0.json b/383/TumorCenter_CD3_block3_x5_y9_patient383_0.json new file mode 100644 index 0000000000000000000000000000000000000000..297149da67a5f5cea5d616e7055026bd8225fd52 --- /dev/null +++ b/383/TumorCenter_CD3_block3_x5_y9_patient383_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15634.7, + "Centroid Y µm": 28807.1, + "Num Detections": 18771, + "Num Negative": 18166, + "Num Positive": 605, + "Positive %": 3.223, + "Num Positive per mm^2": 245.19 + } +} \ No newline at end of file diff --git a/383/TumorCenter_CD3_block3_x6_y9_patient383_1.json b/383/TumorCenter_CD3_block3_x6_y9_patient383_1.json new file mode 100644 index 0000000000000000000000000000000000000000..45f25b7ed50682015d2fe3c6f841282179e46aa1 --- /dev/null +++ b/383/TumorCenter_CD3_block3_x6_y9_patient383_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18190.4, + "Centroid Y µm": 29009.6, + "Num Detections": 20331, + "Num Negative": 19980, + "Num Positive": 351, + "Positive %": 1.726, + "Num Positive per mm^2": 137.57 + } +} \ No newline at end of file diff --git a/383/TumorCenter_CD8_block3_x5_y9_patient383_0.json b/383/TumorCenter_CD8_block3_x5_y9_patient383_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bff869417237fc20d968af95e901cc31b87b0ad1 --- /dev/null +++ b/383/TumorCenter_CD8_block3_x5_y9_patient383_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 23962.3, + "Num Detections": 18593, + "Num Negative": 18488, + "Num Positive": 105, + "Positive %": 0.5647, + "Num Positive per mm^2": 45.48 + } +} \ No newline at end of file diff --git a/383/TumorCenter_CD8_block3_x6_y9_patient383_1.json b/383/TumorCenter_CD8_block3_x6_y9_patient383_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8ee8455632cdfbc58bfe8a8cdb8585a3024481c5 --- /dev/null +++ b/383/TumorCenter_CD8_block3_x6_y9_patient383_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 24162.2, + "Num Detections": 20214, + "Num Negative": 20142, + "Num Positive": 72, + "Positive %": 0.3562, + "Num Positive per mm^2": 29.14 + } +} \ No newline at end of file diff --git a/383/history_text.txt b/383/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4fa3f5ae588e161c2180945bb1ff94d122566005 --- /dev/null +++ b/383/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Histologically confirmed malignant tumor in the area of the right swallowing duct. Indication for laser resection with neck dissection and tracheotomy. \ No newline at end of file diff --git a/383/icd_codes.txt b/383/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9b132ee47da030b7d4043a5ec8105b93a7d4701d --- /dev/null +++ b/383/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 ] Karzinom Hypopharynx mehrere Teilbereiche überlappend[C13.8 R] Neubildung bösartig sekundär und onA Lymphknoten Kopf Gesicht Hals[C77.0 R] \ No newline at end of file diff --git a/383/ops_codes.txt b/383/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8d132a345e7f45f1562415bb2b6c4088176962a2 --- /dev/null +++ b/383/ops_codes.txt @@ -0,0 +1 @@ +Laserkoagulation Pharynxgewebe[5-292.31 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Permanente Tracheostomaanlage[5-312.0 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] \ No newline at end of file diff --git a/383/patient_clinical_data.json b/383/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d9a9bff2f1b716f1cd50cd28a9c4b95881b1fb5b --- /dev/null +++ b/383/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/383/patient_pathological_data.json b/383/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ef6728c9087f03e11f733a9b4cf04736f4407dda --- /dev/null +++ b/383/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "383", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/383/surgery_description.txt b/383/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4f1b3646d8f9e116a66e0ae42fe9ea76ca8bc8fe --- /dev/null +++ b/383/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy diff --git a/383/surgery_report.txt b/383/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ea3903e1d325c8de5f9b2114541f13f2f44693b6 --- /dev/null +++ b/383/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthetist. Then exposure of the tumor in the area of the lateral pharyngeal wall using the spreading laryngoscope. The tumor can be sufficiently exposed. The tumor begins in the area of the lateral pharyngeal wall, extends to the entrance of the piriform sinus and via the pharyngoepiglottic plica to the epiglottis. Cutting around the tumor with the laser, whereby exposure during preparation is difficult. The tumor is resected with the lateral pharyngeal wall and the pharyngoepiglottic plica. To ensure safe resection, a portion of the large hyoid horn is also resected from the inside. Careful hemostasis. As far as can be assessed intraoperatively, the resection is successful in healthy tissue. Two marginal samples are taken, which confirm the resection in healthy tissue in a frozen section. Repeated hemostasis. Dry conditions. Repositioning of the patient. Application of local anesthesia in the area of the right neck. Abjode and cover the surgical area. Skin incision starting from the mastoid, along the anterior edge of the sternocleidomastoid muscle to the clavicle. Cut through the subcutaneous tissue. Exposure of the auricularis magnus nerve. Cranial displacement and re-embedding of the nerve in the sense of neurolysis at the end of the operation. Exposure of the sternocleidomastoid muscle. Exposure of the vascular nerve sheath with V. jugularis interna, A. carotis communis, A. carotis interna/externa, N. vagus, N. hypoglossus. Visualization of the accessorius nerve. Displacement of these structures during dissection and re-embedding in their original bed at the end of dissection. The lymphatic and connective tissue in the area of levels II to V is completely removed. In the area of level V, large lymph nodes are visible, which obviously merge into a thoracic duct. A caudal ligation is made here to avoid chyle flow. This results in a modified radical neck dissection on the right side, which comprises levels II to V. Careful hemostasis. Insertion of a Redon drain. Wound closure in layers. Application of a pressure dressing. Repositioning of the patient. Application of local anesthesia above the larynx and the cervical trachea. Transverse skin incision. Cut through the subcutaneous tissue. Exposure of the infrahyoid musculature. Exposure of the linea alba. Dissection of the cricoid cartilage and the trachea. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus and exposure of the anterior wall of the trachea. Careful dissection of the trachea and performance of a small tracheotomy between the second and third tracheal rings. Epithelialization of the tracheostoma. Insertion of the tracheal cannula. Wound closure. Application of wound dressing. Final consultation with the anesthetist. The patient is transferred to the intensive care unit. \ No newline at end of file diff --git a/384/InvasionFront_CD3_block11_x5_y8_patient384_0.json b/384/InvasionFront_CD3_block11_x5_y8_patient384_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2da7e7b002f4faed9c356be6e97d6a6699cd876e --- /dev/null +++ b/384/InvasionFront_CD3_block11_x5_y8_patient384_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 19114.9, + "Num Detections": 6745, + "Num Negative": 6643, + "Num Positive": 102, + "Positive %": 1.512, + "Num Positive per mm^2": 131.36 + } +} \ No newline at end of file diff --git a/384/InvasionFront_CD3_block11_x6_y8_patient384_1.json b/384/InvasionFront_CD3_block11_x6_y8_patient384_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ef07795cd54ad505f350c7e87d52e11186fb88b3 --- /dev/null +++ b/384/InvasionFront_CD3_block11_x6_y8_patient384_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18365.3, + "Centroid Y µm": 19039.9, + "Num Detections": 3890, + "Num Negative": 3841, + "Num Positive": 49, + "Positive %": 1.26, + "Num Positive per mm^2": 113.21 + } +} \ No newline at end of file diff --git a/384/InvasionFront_CD8_block11_x5_y8_patient384_0.json b/384/InvasionFront_CD8_block11_x5_y8_patient384_0.json new file mode 100644 index 0000000000000000000000000000000000000000..203234208c37b0681ea21bf069d99a830c640180 --- /dev/null +++ b/384/InvasionFront_CD8_block11_x5_y8_patient384_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18531.9, + "Centroid Y µm": 30443.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/384/InvasionFront_CD8_block11_x6_y8_patient384_1.json b/384/InvasionFront_CD8_block11_x6_y8_patient384_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c9a2ba33d72044af1e0072a907ad3c982014d00d --- /dev/null +++ b/384/InvasionFront_CD8_block11_x6_y8_patient384_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20949.0, + "Centroid Y µm": 30346.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/384/TumorCenter_CD3_block11_x5_y8_patient384_0.json b/384/TumorCenter_CD3_block11_x5_y8_patient384_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b43fcaa3a84d9d8ad9245a9e9b99640c4a741bca --- /dev/null +++ b/384/TumorCenter_CD3_block11_x5_y8_patient384_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 20089.4, + "Num Detections": 17967, + "Num Negative": 17405, + "Num Positive": 562, + "Positive %": 3.128, + "Num Positive per mm^2": 269.44 + } +} \ No newline at end of file diff --git a/384/TumorCenter_CD3_block11_x6_y8_patient384_1.json b/384/TumorCenter_CD3_block11_x6_y8_patient384_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5b795c04d9e20fa8ec4f2bda22fc3f8e684ec371 --- /dev/null +++ b/384/TumorCenter_CD3_block11_x6_y8_patient384_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21438.6, + "Centroid Y µm": 20164.3, + "Num Detections": 18335, + "Num Negative": 18024, + "Num Positive": 311, + "Positive %": 1.696, + "Num Positive per mm^2": 134.61 + } +} \ No newline at end of file diff --git a/384/TumorCenter_CD8_block11_x5_y8_patient384_0.json b/384/TumorCenter_CD8_block11_x5_y8_patient384_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d100bfac1090dae27f33efd909ddefc8b39c2abe --- /dev/null +++ b/384/TumorCenter_CD8_block11_x5_y8_patient384_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 19739.5, + "Num Detections": 19584, + "Num Negative": 19312, + "Num Positive": 272, + "Positive %": 1.389, + "Num Positive per mm^2": 118.75 + } +} \ No newline at end of file diff --git a/384/TumorCenter_CD8_block11_x6_y8_patient384_1.json b/384/TumorCenter_CD8_block11_x6_y8_patient384_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e8a60af7d207aff6001984dc6137cbe2905e9a10 --- /dev/null +++ b/384/TumorCenter_CD8_block11_x6_y8_patient384_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18915.0, + "Centroid Y µm": 19889.5, + "Num Detections": 18661, + "Num Negative": 18570, + "Num Positive": 91, + "Positive %": 0.4876, + "Num Positive per mm^2": 40.06 + } +} \ No newline at end of file diff --git a/384/history_text.txt b/384/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..98100b13a6f963d4f08577a2c4450f70d86d302d --- /dev/null +++ b/384/history_text.txt @@ -0,0 +1 @@ +In the patient with supraglottic laryngeal carcinoma in 1984 with surgical treatment by means of partial laryngeal resection and neck dissection as well as adjuvant radiochemotherapy, a right oropharyngeal carcinoma was histologically confirmed during a panendoscopy, so that after clarification of the vascular situation in the multimorbid patient, the indication for surgical resection with flap coverage now existed. \ No newline at end of file diff --git a/384/icd_codes.txt b/384/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/384/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/384/ops_codes.txt b/384/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6ce97b021e0a2c364fa9ebd26115fad08feb15bf --- /dev/null +++ b/384/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection]: Radikal, modifiziert: 4 Regionen[5-403.20 R] Exzision und Destruktion von erkranktem Gewebe des Pharynx: Exzision, lokal[5-292.0 ] Pharyngoplastik: Mit mikrovaskulär anastomosiertem Transplantat[5-293.2 ] Inzision Muskel quer Oberschenkel und Knie[5-850.18 R] Transfusion von 1-5 TE Vollblut[8-800.0 ] Reoperation[5-983 ] Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.98 R] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 \ No newline at end of file diff --git a/384/patient_clinical_data.json b/384/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1f9e76d1b69baa5c54253c398d5359708306be94 --- /dev/null +++ b/384/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 66, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": null, + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/384/patient_pathological_data.json b/384/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..13475ec540a5b01ddda9a058ed0e1e2ff81d4695 --- /dev/null +++ b/384/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "384", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/384/surgery_description.txt b/384/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8ecb3f80c01feadf179f41d7221c18605ffc17bc --- /dev/null +++ b/384/surgery_description.txt @@ -0,0 +1 @@ +Combined tumor resection, Defect coverage, Free flap (ALT), Right neck dissection, Tracheotomy diff --git a/384/surgery_report.txt b/384/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..c2e9816c44830b8a5f7e4fd28ef474fc7ea1382c --- /dev/null +++ b/384/surgery_report.txt @@ -0,0 +1 @@ +After intubation by the anesthesia colleagues, inspection of the tumor region with the mouth retractor and the small bore tube. Starting in the area of the soft palate on the right, an ulcerating, rather flat tumor is seen, which grows on the right side to the parauvular region and consumes the tonsil region. The alveolar ridge is free on palpation. The change extends over the glossotonsillar groove to the tongue, but does not infiltrate it; growth continues caudally over the lateral pharyngeal wall into the piriform sinus entrance. Here, further growth in terms of longitudinal extension, therefore a clear cT3 finding. After partial laryngectomy with residual epiglottis and tilted laryngeal skeleton, otherwise clear conditions. No evidence of laryngeal infiltration. Initially start with transoral resection. Insertion of the McIvor blade. Resection of the tumor with a safety margin of at least 1 ˝ cm. The uvula is removed in the area of the soft palate. Subtotal resection of the soft palate. Removal of the entire tonsil lobe and removal of the glossotonsillar groove. Macroscopically in sano on all sides. No evidence of basal growth in depth. Therefore, enoral sampling in the area of the soft palate and at the buccal margins. These are assessed as tumor-free in the frozen section diagnostics. Now repositioning for transcervical implication of the resection, preoperative ycN0 neck status. Submandibular skin incision at the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous scar plate. Careful and laborious dissection. Exposure of remnants of the sternocleidomastoid muscle. Pronounced scarring and blocking. Exposure of the internal jugular vein. Exposure of the common carotid artery. A superior thyroid artery can no longer be visualized. Also anteriorly scarred conditions without residual neck preparation. In level III and, after exposure of the submandibular gland and the extremely scarred digastric muscle, removal of a small amount of scar and fatty tissue. These are sent as a neck resectate for definitive histology. Exposure of the hypoglossal nerve. Exposure of the lingual artery and the ascending pharyngeal artery and exposure of the superior laryngeal artery. An accessorius nerve can no longer be visualized. Now release the digastric muscle. Exposure of the hyoid. Exposure of the thyroid cartilage horn. Now entering the hyoid laterally on the right. Very thin conditions here. Direct transition from scar tissue to enoral and here already conspicuous tissue. When the pharyngotomy is widened, contact is made with the pharyngeal tumor extension in the area of the right hypopharynx. Therefore, the hyoid is now removed. Widening of the pharyngotomy. Now a good overview of the tumor. Inclusion of the vallecula, epiglottis margin and a tongue base cuff and completion of the resection area towards the glossotonsillar groove. Now resect the pharynx to just before the middle of the hypopharynx and connect the resection area to the posterior pharyngeal wall. Now continue to expose the carotid artery and remove the entire soft tissue block subcutaneously. The tumor is now completely resected. In the area of the tumor injury during the pharyngotomy, the tumor was removed in a circumscribed and controlled manner for a better overview. Except for the caudal tumor cone, the R2 situation is marked here. Complete control of the basal tissue by exposing the common carotid artery and including the hyoid as well as the thyroid cartilage horn on the right. Inclusion of the entire tissue block. Cut around the residual tumor cone, which is located in front of the piriform sinus entrance. Finally, remove a strip of mucosa in the area of the caudal pharynx, towards the hypopharynx and the posterior pharyngeal wall, leaving a clear safety margin. All resectates are sent for frozen section diagnostics. Here, the area of the main specimen is clear except for the marked caudal margin, but with a narrow resection distance to the basal side. As already described, the entire cervical tissue was resected here. The caudal tumor cone also shows tumor-free margins in the resection area. The post-resectate is completely tumor-free. Therefore, due to the cervical resection of the wound bed or tumor bed and the free mucosal margins, a definitive R0 situation can be assumed. An approx. 2-3 mm thick vein accompanying the occipital artery was already secured in level IIa. Sufficient drainage to the mastoid was ensured. The prerequisites for a microvascular connection are therefore present. Due to the patient's slender proportions and the fresh humerus fracture, the decision was made to cover the defect using an ALT graft from the right. After marking the landmarks, doppler sonographic identification of two main peforators. Marking of a graft measuring 12 x 5.5. Medial incision. Separation of skin and subcutaneous tissue. Exposure of the fascial plane. Exposure of the rectus femoris muscle. Clamping of the muscle cord. Subfascial dissection. Exposure of the vascular pedicle. It becomes apparent that both the ramus desendens and the ramus oblique of the lateral circumflex perforators are branching off into the graft. It was therefore decided to take both branches. Further exposure of the vascular pedicle. Visualization of the confluence of both branches. A common arterial inflow can be visualized. Visualization of the perforators, these are well developed. Complete cutting of the graft. Cut through to the fascia lata. Taking along the fascia lata and salvaging the graft while taking along a sufficiently protective muscle cuff around the perforators. Careful protection of the perforators. Isolation to the exposed artery and a strong vein and, with excellent flap perfusion, placement of the graft. Careful wound inspection, dry conditions after ligation of vascular stumps, dry conditions after wound irrigation with Ringer's solution. Insertion of a 10 Redon drain and careful, two-layer wound closure. Now successive placement of 3/0 Vicryl mucosal sutures transcervically. Then pull the graft through enorally. Here, advance in the area of the posterior palatal arch or the soft palate dorsally and towards the nasopharynx. Incorporation of the graft enorally and complete suturing over the transcervically placed sutures. Finally, tight conditions. Good graft fit. Now prepare the lingual artery for vascularization. However, this is not continuous. No flow here even after shortening. Therefore clipping of the artery. Now expose the ascending pharyngeal artery. This shows a regular, good flow. Suturing conditions are now much more difficult due to the course of the vessel. Careful vessel position. Performing the vascular suture with 8/0 Ethilon. After reopening the Acland clamps, initially lack of perfusion, but excellent flow after repositioning the flap and handle. Immediate venous return and excellent flap vitality enorally. Then preparation of the occipital vein. Measurement of a 2.5 mm coupler, limited by the diameter of the occipital vein. Perform the coupler anastomosis. After reopening the clamps, immediate good perfusion of the graft and regular enoral vitality. Control of the course of the pedicle. The venous anastomosis now results in a tortuous but stable course without any significant tendency to kink. Positioning of the muscle cuff and careful, two-layer wound closure. Insertion of a flap. Control of the graft at the end of the operation. Excellent flap vitality. Transfer of the patient to the intensive care unit. A tracheotomy had already been performed previously. For this, a skin incision was made approx. 1 cm below the cricoid cartilage and a small access was made to avoid connecting the two wound cavities. Exposure of the cricoid cartilage and the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring. Insertion of a broad-based pedicled Björk flap. Incision of the Björk flap and the trachea. Performance of the mucocutaneous anastomosis. Subsequent problem-free reintubation to an 8-gauge Rüsch cannula. Conclusion: Intraoperative R0-resected ycT3 ycN0 oropharyngeal carcinoma on the right. Postoperatively, please monitor the flap minutely. Postoperative X-ray gruel swallow on the 10th postoperative day due to pre-irradiation. After receiving the definitive histology, presentation at our interdisciplinary tumor conference to consider adjuvant therapy options. \ No newline at end of file diff --git a/385/InvasionFront_CD3_block9_x1_y11_patient385_0.json b/385/InvasionFront_CD3_block9_x1_y11_patient385_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0c2db743de14b600de2f17a40274da8aaeadc684 --- /dev/null +++ b/385/InvasionFront_CD3_block9_x1_y11_patient385_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3911.4, + "Centroid Y µm": 27352.9, + "Num Detections": 15140, + "Num Negative": 14831, + "Num Positive": 309, + "Positive %": 2.041, + "Num Positive per mm^2": 145.32 + } +} \ No newline at end of file diff --git a/385/InvasionFront_CD3_block9_x2_y11_patient385_1.json b/385/InvasionFront_CD3_block9_x2_y11_patient385_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5a95ed1c0e8f80b456d6df1eb87d408859e4135e --- /dev/null +++ b/385/InvasionFront_CD3_block9_x2_y11_patient385_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 27785.3, + "Num Detections": 16235, + "Num Negative": 16182, + "Num Positive": 53, + "Positive %": 0.3265, + "Num Positive per mm^2": 25.57 + } +} \ No newline at end of file diff --git a/385/InvasionFront_CD8_block9_x1_y11_patient385_0.json b/385/InvasionFront_CD8_block9_x1_y11_patient385_0.json new file mode 100644 index 0000000000000000000000000000000000000000..49eeddeefa07a1bd583010afb030d03dee208bf2 --- /dev/null +++ b/385/InvasionFront_CD8_block9_x1_y11_patient385_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4085.5, + "Centroid Y µm": 30803.4, + "Num Detections": 15278, + "Num Negative": 15169, + "Num Positive": 109, + "Positive %": 0.7134, + "Num Positive per mm^2": 53.06 + } +} \ No newline at end of file diff --git a/385/InvasionFront_CD8_block9_x2_y11_patient385_1.json b/385/InvasionFront_CD8_block9_x2_y11_patient385_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a8a64b49bdb6311c52b20287ead6b4a8af4bd8c4 --- /dev/null +++ b/385/InvasionFront_CD8_block9_x2_y11_patient385_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6690.8, + "Centroid Y µm": 31117.0, + "Num Detections": 18812, + "Num Negative": 18803, + "Num Positive": 9, + "Positive %": 0.0478, + "Num Positive per mm^2": 4.446 + } +} \ No newline at end of file diff --git a/385/TumorCenter_CD3_block9_x1_y11_patient385_0.json b/385/TumorCenter_CD3_block9_x1_y11_patient385_0.json new file mode 100644 index 0000000000000000000000000000000000000000..437f54dd8561348abc79d60587b25c683e1f81b9 --- /dev/null +++ b/385/TumorCenter_CD3_block9_x1_y11_patient385_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3523.1, + "Centroid Y µm": 32807.6, + "Num Detections": 20211, + "Num Negative": 16383, + "Num Positive": 3828, + "Positive %": 18.94, + "Num Positive per mm^2": 1623.8 + } +} \ No newline at end of file diff --git a/385/TumorCenter_CD3_block9_x2_y11_patient385_1.json b/385/TumorCenter_CD3_block9_x2_y11_patient385_1.json new file mode 100644 index 0000000000000000000000000000000000000000..37de836103c227d59ebecf6107601e397512b037 --- /dev/null +++ b/385/TumorCenter_CD3_block9_x2_y11_patient385_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6221.7, + "Centroid Y µm": 32982.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/385/TumorCenter_CD8_block9_x1_y11_patient385_0.json b/385/TumorCenter_CD8_block9_x1_y11_patient385_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0ce83c6d214a3eb5734e4ee10a367c464f542c0b --- /dev/null +++ b/385/TumorCenter_CD8_block9_x1_y11_patient385_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 29134.6, + "Num Detections": 20943, + "Num Negative": 18268, + "Num Positive": 2675, + "Positive %": 12.77, + "Num Positive per mm^2": 1117.9 + } +} \ No newline at end of file diff --git a/385/TumorCenter_CD8_block9_x2_y11_patient385_1.json b/385/TumorCenter_CD8_block9_x2_y11_patient385_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2bc93882b4044ad0a996f8c4f99c60ad7adfe1b6 --- /dev/null +++ b/385/TumorCenter_CD8_block9_x2_y11_patient385_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6821.4, + "Centroid Y µm": 29034.6, + "Num Detections": 13567, + "Num Negative": 13496, + "Num Positive": 71, + "Positive %": 0.5233, + "Num Positive per mm^2": 39.14 + } +} \ No newline at end of file diff --git a/385/history_text.txt b/385/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..609ccfc9bb24837ff532797d2f4cc96c2c0e7272 --- /dev/null +++ b/385/history_text.txt @@ -0,0 +1 @@ +Patient with cT3 cN0 oropharyngeal carcinoma. After panendoscopy and CT findings, spread of the oropharyngeal carcinoma from the tonsillar lobe on the left over the palatal arch to the pharyngeal side wall on the right. In this case, progression to the base of the tongue. Therefore, the above-mentioned surgery is indicated. \ No newline at end of file diff --git a/385/icd_codes.txt b/385/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..60baf9cf45b7cc63d0cdf4e5c0eacf62177a45b5 --- /dev/null +++ b/385/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 B] \ No newline at end of file diff --git a/385/ops_codes.txt b/385/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e5f2ab60c7a02b6331fe64bb292a4c30863aed62 --- /dev/null +++ b/385/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Zungenamputation mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Transorale radikale Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 L] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Entnahme von Spalthaut am Oberschenkel[5-901.0e R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Temporäre Tracheotomie[5-311.0 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/385/patient_clinical_data.json b/385/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..eedc8fd96af8d9c5c17cea08464fcccdb74b0b45 --- /dev/null +++ b/385/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/385/patient_pathological_data.json b/385/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8f603be167d08e082cfa7f284c634d3c4e1b5117 --- /dev/null +++ b/385/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "385", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/385/surgery_description.txt b/385/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..835d99c576c58a323eb7765f11d4e1f0751905ea --- /dev/null +++ b/385/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Defect coverage, Free flap (Radial), Tracheostomy creation diff --git a/385/surgery_report.txt b/385/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..706b197e7c6bead2df0428e6ebfaefc4b5a98923 --- /dev/null +++ b/385/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy again: The tumor is seen as already described, confirming the indication for surgery. PEG has already been placed. The first step is transoral tumor resection: the tumor is removed from all sides at a distance of at least 1.5 to 2 cm. Here, parts of the pharyngeal side wall on the left and the entire palatal arch as well as parts of the pharyngeal wall on the right up to the base of the tongue, which must be resected to about 20 to 30 %. The specimen is marked using sutures. In addition, a marginal specimen in the area of the palatal arch on the left up to the tonsil lobe on the left. Both specimens are sent for frozen section. Here still in situ spurs in the area of the palatal arch to the left tonsillar lobe. However, the marginal specimen is free. Nevertheless, another resection of a small strip from the area of the palatal arch to the lower resection margin, which is also included in this marginal specimen. This specimen is also thread-marked for the frozen section. No more tumor extensions here either. Thus now R0 resection. Now extensive hemostasis. Insertion of a hydrogen swab. Transfer to neck dissection, initially on the right: curved skin incision in the typical manner. Then expose the sternocleidomastoid muscle, the digastric muscle, the omohyoid muscle and the infrahyoid muscles. Subsequent visualization of the cervical vascular sheath, internal jugular vein, common carotid artery, external carotid artery, internal carotid artery. Visualization of the facial vein. Exposure of vagus nerve, accessorius nerve and hypoglossal nerve. Exposure and preservation of the superior thyroid artery. Successive creation of a neck dissection including nodes level II to V. Branches of the cervical plexus are preserved. Subsequent left neck dissection: This is performed in the same way as on the right side. Here, however, the neck dissection is limited to levels II to IV. Here too, careful hemostasis and irrigation with hydrogen and Ringer's solution. Subsequent tracheostoma creation: small Kocher collar incision. Subsequent dissection through subcutaneous tissue to the infrahyoid musculature. Splitting of these. Exposure of the thyroid isthmus. This is clamped off, severed and supplied by means of puncture ligatures. Exposure of the trachea. Creation of a broadly pedicled, modified Björk flap. Subsequent epithelialization of the Björk flap. Re-intubation and insertion of a size 8 tracheal cannula, which is fixed with sutures. Now remove the radial artery from the left forearm: Measure the required area of the flap, which is just under 15 x just under 7 cm. Mark the flap in the required size and orientation. Then cut around the flap, initially from the ulnar side. Extend the incision into the crook of the elbow. Exposure of the superficial venous system, which is included in the graft. Subsequent incision of the flap from the radial side. Exposure and preservation of the lateral antebrachial cutaneous nerve. Then exposure of the radial artery. This is first clamped for 15 to 20 minutes. Subsequently, the vascular pedicle is first exposed at the top. Exposure of the connection between the superficial and deep venous system. Then again locate the radial artery. Always good saturation of the hand with 100% saturation. Deposition of the radial artery. This is treated with 4-0 Prolene stitches. Anti-shear suture in the flap area. The flap is then lifted subfascially along the flap pedicle. Outgoing vessels are treated bipolar or with clips. Dissection along the pedicle up to the olecranon. Here, after clamping and with good saturation, the interosseous artery is removed. Two branches of the superficial venous system can be dissected as connecting vessels. The deep venous system consists of very small vessels, the confluence is very thin. Finally, the flap is placed on the brachial artery, here treated with a 6-0 Vascufil suture. Deposition at the confluence with a clip. Deposition at both ends of the superficial venous system and treatment with ligatures. Flushing of the flap with heparin. Subsequent insertion of the flap into the pharyngeal defect: First create a tunnel approx. 3 transverse fingers wide through the remaining pharyngeal muscles on the right side. Then pull the stalk through. Successive suturing of the flap into the defect, which begins at the base of the tongue or at the hypopharyngeal junction and extends to the opposite tonsil lobe. Tension-free suturing using 3-0 Vicryl single button sutures. Then vascular anastomoses in the neck area. Conditioning of the superior thyroid artery and the radial artery. These are connected using 8-0 Ethilon single-button sutures. After opening the clamps, good arterial flow and good venous return. The veins are conditioned. Both superficial veins are connected with 2 outlets from the facial artery. The 1st with a 3.0 mm coupler, the 2nd with a 2.0 mm coupler. Good venous return can be seen here in each case, positive smear phenomenon. Good aspect of the flap now also enoral. Subsequent careful hemostasis and irrigation of both sides of the neck. Wound closure in layers with insertion of a Redon drain in both sides of the neck, guided on the right. Now closure of the forearm defect: Split skin with a thickness of 0.7 to 0.8 mm is removed from the thigh area using a dermatome. This is successively incorporated into the forearm defect. The skin incision in the direction of the crook of the elbow is closed in layers. The arm is always well supplied with blood. Then bandage with hydrogel, Mepilex. Loose compresses placed on top. Wrap in absorbent cotton. Fitting of a Kramer splint, which is fixed with an elastic bandage. Finally, positioning of the arm. Completion of the procedure without complications. The patient is ventilated and transferred to the intensive care unit for monitoring. Please continue antibiotics with Unacid for 1 week. Heparin perfusor, which was started intraoperatively at 500 units per hour, should be continued for 5 days postoperatively. Feeding via the previously inserted PEG tube for 10 days, then gruel and, if necessary, diet build-up. Check the flap clinically and, if necessary, by Doppler according to the scheme. Wait for the final histology. Discussion of further procedure in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/386/InvasionFront_CD3_block17_x3_y10_patient386_0.json b/386/InvasionFront_CD3_block17_x3_y10_patient386_0.json new file mode 100644 index 0000000000000000000000000000000000000000..14637b26cb019ae797f6378b89351149fb49a1af --- /dev/null +++ b/386/InvasionFront_CD3_block17_x3_y10_patient386_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10619.4, + "Centroid Y µm": 30034.1, + "Num Detections": 20170, + "Num Negative": 19466, + "Num Positive": 704, + "Positive %": 3.49, + "Num Positive per mm^2": 297.16 + } +} \ No newline at end of file diff --git a/386/InvasionFront_CD3_block17_x4_y10_patient386_1.json b/386/InvasionFront_CD3_block17_x4_y10_patient386_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d175953912614bac25bb1a78d7bdbac5ec082394 --- /dev/null +++ b/386/InvasionFront_CD3_block17_x4_y10_patient386_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 30209.0, + "Num Detections": 16716, + "Num Negative": 16406, + "Num Positive": 310, + "Positive %": 1.855, + "Num Positive per mm^2": 155.92 + } +} \ No newline at end of file diff --git a/386/InvasionFront_CD8_block17_x3_y10_patient386_0.json b/386/InvasionFront_CD8_block17_x3_y10_patient386_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8490362186903e86dd07c54ff72b5437191fe7ce --- /dev/null +++ b/386/InvasionFront_CD8_block17_x3_y10_patient386_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 24961.8, + "Num Detections": 19987, + "Num Negative": 19011, + "Num Positive": 976, + "Positive %": 4.883, + "Num Positive per mm^2": 409.48 + } +} \ No newline at end of file diff --git a/386/InvasionFront_CD8_block17_x4_y10_patient386_1.json b/386/InvasionFront_CD8_block17_x4_y10_patient386_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d8e2ae93dba937c533eac91dcd69cbc6ac2bb35e --- /dev/null +++ b/386/InvasionFront_CD8_block17_x4_y10_patient386_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13767.7, + "Centroid Y µm": 25061.7, + "Num Detections": 18651, + "Num Negative": 18290, + "Num Positive": 361, + "Positive %": 1.936, + "Num Positive per mm^2": 157.61 + } +} \ No newline at end of file diff --git a/386/TumorCenter_CD3_block17_x3_y10_patient386_0.json b/386/TumorCenter_CD3_block17_x3_y10_patient386_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65b499dbc0ea6eb84043c63fb939d5ecab6d4a8c --- /dev/null +++ b/386/TumorCenter_CD3_block17_x3_y10_patient386_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10794.3, + "Centroid Y µm": 24686.9, + "Num Detections": 19239, + "Num Negative": 18649, + "Num Positive": 590, + "Positive %": 3.067, + "Num Positive per mm^2": 269.1 + } +} \ No newline at end of file diff --git a/386/TumorCenter_CD3_block17_x4_y10_patient386_1.json b/386/TumorCenter_CD3_block17_x4_y10_patient386_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65407b447e47e3d2c8f921db145ab946773ea523 --- /dev/null +++ b/386/TumorCenter_CD3_block17_x4_y10_patient386_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12718.3, + "Centroid Y µm": 25061.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/386/TumorCenter_CD8_block17_x3_y10_patient386_0.json b/386/TumorCenter_CD8_block17_x3_y10_patient386_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e6dd2bd31779764fa2965139eb1bce658837b563 --- /dev/null +++ b/386/TumorCenter_CD8_block17_x3_y10_patient386_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 38479.6, + "Num Detections": 19095, + "Num Negative": 18867, + "Num Positive": 228, + "Positive %": 1.194, + "Num Positive per mm^2": 102.16 + } +} \ No newline at end of file diff --git a/386/TumorCenter_CD8_block17_x4_y10_patient386_1.json b/386/TumorCenter_CD8_block17_x4_y10_patient386_1.json new file mode 100644 index 0000000000000000000000000000000000000000..214f4525cd3767bc779e7ed1aff874034be57b80 --- /dev/null +++ b/386/TumorCenter_CD8_block17_x4_y10_patient386_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 38479.6, + "Num Detections": 17292, + "Num Negative": 16815, + "Num Positive": 477, + "Positive %": 2.759, + "Num Positive per mm^2": 238.76 + } +} \ No newline at end of file diff --git a/386/history_text.txt b/386/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8299c83c4971c47d15ff4373141902eb8997920f --- /dev/null +++ b/386/history_text.txt @@ -0,0 +1 @@ +A cT1a glottic laryngeal carcinoma was histologically confirmed externally in the patient. There is now an indication for tumor resection. Primarily, a transoral attempt at laser resection is planned. If this is not possible, an external approach via a thyrofissure was also discussed with the patient. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/386/icd_codes.txt b/386/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..564bb0fabaafe855c2d0ec05b63821bd04908401 --- /dev/null +++ b/386/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 B] Bösartige Neubildung der Ohrhelix[C44.2 L] \ No newline at end of file diff --git a/386/ops_codes.txt b/386/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..263d971eda7cc1c0b9b57164ba2a18750a96b825 --- /dev/null +++ b/386/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Chordektomie durch Thyreotomie[5-302.2 ] Ohrmuschelresektion partiell histographisch kontrolliert [mikrographische Chirurgie][5-182.1 L] \ No newline at end of file diff --git a/386/patient_clinical_data.json b/386/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bd72920eab8f1bc827d051d0a7adac79b7bcd25e --- /dev/null +++ b/386/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 68, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 63, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/386/patient_pathological_data.json b/386/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..74644c7f8d9b6ef20d725da2748daaefb76d5768 --- /dev/null +++ b/386/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "386", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1b", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/386/surgery_description.txt b/386/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..612a816e5642377db7ee4b2d33469bdad279d750 --- /dev/null +++ b/386/surgery_description.txt @@ -0,0 +1 @@ +Partial laryngeal resection diff --git a/386/surgery_report.txt b/386/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..77c999c33fef0babcd09c3864ed3a865eb122744 --- /dev/null +++ b/386/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with anesthesia. Induction of anesthesia and transition to tracheoscopy. This turns out to be extremely difficult. With great effort, the anesthesia colleagues manage to intubate the patient using the Glidescope optics. After fixing the tube, the surgeon positions the patient. Insertion of the mouth guard. Enter with the size D small bore tube. The endolarynx cannot be adequately monitored with this. Even after several attempts, the tumor in the area of the right vocal fold cannot be adequately adjusted, so the decision is made to resect the tumor via an external approach through a thyrofissure. Removal of the small drainage tube. Repositioning of the patient. Skin spray disinfection and infiltration anesthesia. Skin wipe disinfection and sterile draping. Palpatory identification of the thyroid cartilage and the thyroid incisura. Mark the planned incision horizontally in a skin fold. Cut sharply through the cutis and subcutis. Expose the prelaryngeal musculature. Locate the midline. Lateralization of the prelarygneal musculature. Exposure of the thyroid cartilage. This dives relatively far into the depths. Therefore significantly more difficult preparation conditions. Subsequently, first incise the periosteum over the entire length of the thyroid cartilage. Subsequently, horizontal incision of the ligamentum conicum. Dissect two perichondrium flaps and lateralize them to the left and right. Subsequently, opening of the larynx in the median line in the sense of a thyrofissure using the oscillating wheel. Insertion of the three-pronged retractor. After the larynx has been opened in the median line, it can be seen that the right vocal fold is subtotally affected by the tumor. This extends from the vocal process beyond the anterior commissure to the left middle third of the vocal fold. First resection of the tumor in the area of the right vocal fold, including the ligament and the vocalis muscle. The same procedure is also carried out on the left side. Here, the ligament and the vocalis muscle are resected up to the middle third of the vocal fold. The resection margins are now inspected with the aid of the rigid endoscope. Slightly suspicious mucosal changes appear in the area of the medial surface of the arytenoid. First dissect the mucosa with the FREER. Then take circular margin samples on the right and left side ( right vocal fold margin sample cranial and caudal, left vocal fold margin sample cranial and caudal ). Since the tumor went over the anterior commissure, the periosteum in the area of the anterior commissure is now also resected. In addition, grinding of the anterior commissure of the thyroid cartilage with the diamond burr. Hemostasis is achieved by inserting a suprarenin-impregnated laryngeal swab and bipolar coagulation. During the telephone frozen section, tumor-free margin samples are found on all sides. Therefore, proceed to laryngeal closure. Creation of four drill holes in the area of the thyroid cartilage. Insertion of a 14 mm laryngeal wedge. Closure of the thyrofissure and suturing of the Keel with PDS 4-0, followed by retraction of the perichondrium flaps and complete covering of the Keel. Suture the incision in the area of the ligamentum conicum. Readaptation of the prelaryngeal muscle bellies in the median line. Additional mobilization of the lateral laryngeal bellies and medialization of the same and also fixation of the same using continuous sutures with Vicryl 4-0. Finally, insertion of a flap. Subcutaneous suture with Vicryl 4-0 and skin suture with Ethilon 5-0. Suturing of the flap. Application of a wound dressing and a compression bandage. Proceed to resection of the suspicious efflorescence in the area of the left helix. Marking of the planned incision. Spindle-shaped incision of the suspicious mass. Suture marking of the mass. Hemostasis using bipolar coagulation. Successive mobilization of the cutis and primary wound closure following a rapid incision announcement of R0 status by telephone. Application of a wound dressing. Final consultation with the anesthetist. Completion of the operation without complications. \ No newline at end of file diff --git a/387/InvasionFront_CD3_block8_x3_y8_patient387_0.json b/387/InvasionFront_CD3_block8_x3_y8_patient387_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ac6b814bffe2681a20f506201f3446ed29992a45 --- /dev/null +++ b/387/InvasionFront_CD3_block8_x3_y8_patient387_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11294.0, + "Centroid Y µm": 30259.0, + "Num Detections": 18400, + "Num Negative": 14753, + "Num Positive": 3647, + "Positive %": 19.82, + "Num Positive per mm^2": 1540.7 + } +} \ No newline at end of file diff --git a/387/InvasionFront_CD3_block8_x4_y8_patient387_1.json b/387/InvasionFront_CD3_block8_x4_y8_patient387_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67c32641e9aa7e876065fbaf313ddff24bbb9eae --- /dev/null +++ b/387/InvasionFront_CD3_block8_x4_y8_patient387_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13742.7, + "Centroid Y µm": 30159.0, + "Num Detections": 20017, + "Num Negative": 18593, + "Num Positive": 1424, + "Positive %": 7.114, + "Num Positive per mm^2": 588.78 + } +} \ No newline at end of file diff --git a/387/InvasionFront_CD8_block8_x3_y8_patient387_0.json b/387/InvasionFront_CD8_block8_x3_y8_patient387_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4f7e668874d264441882fb8b5ba3c00b9514ef63 --- /dev/null +++ b/387/InvasionFront_CD8_block8_x3_y8_patient387_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 20314.2, + "Num Detections": 17348, + "Num Negative": 10626, + "Num Positive": 6722, + "Positive %": 38.75, + "Num Positive per mm^2": 2838.6 + } +} \ No newline at end of file diff --git a/387/InvasionFront_CD8_block8_x4_y8_patient387_1.json b/387/InvasionFront_CD8_block8_x4_y8_patient387_1.json new file mode 100644 index 0000000000000000000000000000000000000000..23cf9272067c9ce093f542939c5a32b2c3c95313 --- /dev/null +++ b/387/InvasionFront_CD8_block8_x4_y8_patient387_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 20489.2, + "Num Detections": 21047, + "Num Negative": 18828, + "Num Positive": 2219, + "Positive %": 10.54, + "Num Positive per mm^2": 904.4 + } +} \ No newline at end of file diff --git a/387/TumorCenter_CD3_block8_x3_y8_patient387_0.json b/387/TumorCenter_CD3_block8_x3_y8_patient387_0.json new file mode 100644 index 0000000000000000000000000000000000000000..88d5c4315d4e03e7a4013fa6cb410e6fe38afa4f --- /dev/null +++ b/387/TumorCenter_CD3_block8_x3_y8_patient387_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12443.4, + "Centroid Y µm": 20913.9, + "Num Detections": 15823, + "Num Negative": 14319, + "Num Positive": 1504, + "Positive %": 9.505, + "Num Positive per mm^2": 662.27 + } +} \ No newline at end of file diff --git a/387/TumorCenter_CD3_block8_x4_y8_patient387_1.json b/387/TumorCenter_CD3_block8_x4_y8_patient387_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fbc98e2e96ffae8c24f745cdb2a1d91062f1430c --- /dev/null +++ b/387/TumorCenter_CD3_block8_x4_y8_patient387_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14942.1, + "Centroid Y µm": 20564.1, + "Num Detections": 14796, + "Num Negative": 13235, + "Num Positive": 1561, + "Positive %": 10.55, + "Num Positive per mm^2": 711.79 + } +} \ No newline at end of file diff --git a/387/TumorCenter_CD8_block8_x3_y8_patient387_0.json b/387/TumorCenter_CD8_block8_x3_y8_patient387_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fe3bac60a4935cbcda20ddc7f1a54ace93b0bf91 --- /dev/null +++ b/387/TumorCenter_CD8_block8_x3_y8_patient387_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12093.6, + "Centroid Y µm": 20589.1, + "Num Detections": 18548, + "Num Negative": 16182, + "Num Positive": 2366, + "Positive %": 12.76, + "Num Positive per mm^2": 975.65 + } +} \ No newline at end of file diff --git a/387/TumorCenter_CD8_block8_x4_y8_patient387_1.json b/387/TumorCenter_CD8_block8_x4_y8_patient387_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65034a6537ef3152a595d9f47eb60ab9bfa20333 --- /dev/null +++ b/387/TumorCenter_CD8_block8_x4_y8_patient387_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14617.3, + "Centroid Y µm": 20389.2, + "Num Detections": 18043, + "Num Negative": 16899, + "Num Positive": 1144, + "Positive %": 6.34, + "Num Positive per mm^2": 467.31 + } +} \ No newline at end of file diff --git a/387/history_text.txt b/387/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b1b358ce7bd4c5284190195b727243ff611c4ef --- /dev/null +++ b/387/history_text.txt @@ -0,0 +1 @@ +An externally confirmed carcinoma of the base of the tongue was histologically confirmed in the patient during a panendoscopy. In summary, all findings revealed a cT2 cN2c cM0 G2 tongue carcinoma on the right side. In our interdisciplinary tumor conference, the primary surgical procedure was recommended. \ No newline at end of file diff --git a/387/icd_codes.txt b/387/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/387/ops_codes.txt b/387/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9c038338f391f06c3881ae5ecf2c8fd5954a0ed4 --- /dev/null +++ b/387/ops_codes.txt @@ -0,0 +1 @@ +Totale Laserresektion Zunge transoral sonstige[5-252.0x ] Partielle Glossektomie transoral sonstige[5-251.0x ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] PEG-Sonde Anlage[5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Radikale modifizierte Neck dissection in 5 Regionen[5-403.21 B] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/387/patient_clinical_data.json b/387/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e74ef05ab7f0144aced70d3cdc253219228760f6 --- /dev/null +++ b/387/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/387/patient_pathological_data.json b/387/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8006b604e9e8921fff23a8e89ed483fdcd0d9c55 --- /dev/null +++ b/387/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "387", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 4.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.2", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/387/surgery_description.txt b/387/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..d1b40adbedd5d151b5a24d99ddd531158e55d671 --- /dev/null +++ b/387/surgery_description.txt @@ -0,0 +1 @@ +Laser resection, Glossectomy, Neck dissection, Tracheotomy diff --git a/387/surgery_report.txt b/387/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d827abc236982625b5f014706cec57888348192b --- /dev/null +++ b/387/surgery_report.txt @@ -0,0 +1 @@ +After induction and intubation by the anesthesiology colleagues, the PEG is inserted first. This is done with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. Here, with excellent diaphanoscopy, the stomach is punctured without any problems. The PEG tube was then inserted using the usual thread pull-through method. The stomach and oesophagus were unremarkable. Now re-inspection of the primary tumor region. Pharyngo/laryngoscopy revealed a tumor as described above in the area of the right base of the tongue extending into the vallecula and here circumscribed to the epiglottis, tumor extension also on the right side of the pharyngeal side wall. Adjustment of the primary tumor region with the distractor. Successive resection of the primary tumor with the 5 watt CO2 laser. Resection while maintaining a safety distance of approx. 1 cm, very good microscopic control in the mucosal region, caudal resection in the area of the pharyngeal wall below the tonsillar lobe or with partial removal of the tonsillar lobe. Resection in the area of the pharynx superficially under only sparse musculature, taking the musculature up to the entrance of the piriform sinus. Separation from the base of the tongue. Here, under good depth control, complete resection with superficial removal of the right-sided base of the tongue. Resection up to the petiolus. In the area of the medial base of the tongue or towards the middle of the base of the tongue, a tumor cone appears to be pulling into the depths. Therefore, after complete mobilization of the tumour and due to the tumour mass, targeted resection is performed here. Inclusion of the lingual epiglottis surface. No cartilage infiltration here. Inclusion of the vallecula up to the opposite side. No tumor growth towards the aryepiglottic fold. The removed specimen now shows the previously described cone basally, otherwise completely healthy tissue on all sides towards the depth. Slightly narrow resection margins in the area of the vallecula after extirpation, otherwise macroscopically wide in sano resection on all sides. Post-resection is now performed in the area of the tumor cone. This is carried out far into the healthy tissue, also to widen the safety margin in the area of the vallecula. The entire tumor, both in the area of the mucosal margins and basally, is then covered with margin samples. All tumor margin samples are free of tumor and dysplasia, so that an R0 resection is achieved. A protective tracheotomy is then performed in the case of dry enoral wound conditions due to the extensive wound area. To do this, enter horizontally approx. 1 transverse finger below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure of the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Due to the position, insertion between the 1st and 2nd tracheal ring. Performing a visor tracheotomy. Incision with insertion of the mucocutaneous anastomosis. Subsequent problem-free transfer to size 8 low cuff cannula. Neck dissections are then performed. Start with the right side. Submandibular incision along the skin tension lines. Cut through skin and subcutaneous tissue. Dissection of the platysma. Dissection of the platysma. Exposure of the sternocleidomastoid, omohyoid and digastric muscles. As previously described sonographically, a metastasis-suspicious mass measuring approx. 3 cm is seen in the jugulofacial angle. Clearing of the anterior neck preparation with preservation of the facial vein, the superior thyroid artery and the cervical artery. Dissection of the internal jugular vein, which is very strong caudally and tapers significantly in the area of the jugulofacial angle in the area of the metastasis. Preservation of the vein. No growth beyond the capsule. Exposure of the accessorius nerve. Release of the accessorius triangle and release of level V a with careful protection of the cervical plexus branches. Exposure and protection of the vagus nerve, hypoglossal nerve and all external carotid arteries. Initial exposure and protection of the external jugular vein and the auricular nerve. Careful wound inspection. Irrigation with H2O2 and Ringer's solution. Insertion of a 10 Redon drain and careful, two-layer wound closure. Turning to the opposite side. In principle, exactly the same procedure here, after exposing the adjacent and limiting muscles, preservation of the external jugular vein and the auricular nerve. Release of the anterior neck preparation with careful protection of the facial vein, the superior thyroid artery and the cervical artery. Here, too, metastasis-suspected lesion in the jugulofacial angle, here with pronounced widening of the vein. Exposure and preservation of the accessorius nerve. Dissection of the metastasis. Here, too, no growth beyond the capsule, but, as described above, pronounced tapering of the internal jugular vein, which is deposited here at this point, with outgoing vessels and vulnerability, with a cranial caliber thickness of approx. 2 mm. Clearing of the accessorius triangle and, due to the location of the metastasis, also clearing ........... Level V a's. Preservation and protection of the vagus nerve and hypoglossal nerve as well as all external carotid artery branches. Here too, final wound irrigation with H2O2 and Ringer's solution. Finally, dry wound conditions. Insertion of a 10 Redon drain and careful, two-layer wound closure. After applying a wound dressing, re-insertion with the small irrigation tube under dental protection to inspect the wound conditions. Circumscribed punctual monopolar hemostasis. Finally, completely dry wound conditions on all sides and completion of the procedure, after repositioning the patient, without any indication of complications. The patient received intraoperative intravenous antibiotics with Unacid 3 g. Please continue this for 24 hours postoperatively. Conclusion: Intraoperative R0-resected cT2 cN2c tongue base carcinoma on the right. After receiving the definitive histology, presentation at our interdisciplinary tumor conference to determine the adjuvant therapy procedure. Postoperatively, please feed via the inserted PEG tube for at least 5 to 7 days; if the wound is healing properly, oralization with water/tea can be attempted beforehand if necessary. Depending on swallowing function, decannulation from the 7th postoperative day. \ No newline at end of file diff --git a/388/InvasionFront_CD3_block16_x1_y7_patient388_0.json b/388/InvasionFront_CD3_block16_x1_y7_patient388_0.json new file mode 100644 index 0000000000000000000000000000000000000000..46ceea146d281fd442e755bc0b9b98188a6577a1 --- /dev/null +++ b/388/InvasionFront_CD3_block16_x1_y7_patient388_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4454.5, + "Centroid Y µm": 21874.4, + "Num Detections": 16024, + "Num Negative": 14807, + "Num Positive": 1217, + "Positive %": 7.595, + "Num Positive per mm^2": 523.64 + } +} \ No newline at end of file diff --git a/388/InvasionFront_CD3_block16_x2_y7_patient388_1.json b/388/InvasionFront_CD3_block16_x2_y7_patient388_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b237f9ccbfde1f07e7d7955535c2fdc16514c2fe --- /dev/null +++ b/388/InvasionFront_CD3_block16_x2_y7_patient388_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7015.6, + "Centroid Y µm": 22103.4, + "Num Detections": 17071, + "Num Negative": 14924, + "Num Positive": 2147, + "Positive %": 12.58, + "Num Positive per mm^2": 945.91 + } +} \ No newline at end of file diff --git a/388/InvasionFront_CD8_block16_x1_y7_patient388_0.json b/388/InvasionFront_CD8_block16_x1_y7_patient388_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d738b5fd97c1908bd6835e3a40bdf8d58b94c529 --- /dev/null +++ b/388/InvasionFront_CD8_block16_x1_y7_patient388_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3269.9, + "Centroid Y µm": 16931.3, + "Num Detections": 16645, + "Num Negative": 14906, + "Num Positive": 1739, + "Positive %": 10.45, + "Num Positive per mm^2": 738.58 + } +} \ No newline at end of file diff --git a/388/InvasionFront_CD8_block16_x2_y7_patient388_1.json b/388/InvasionFront_CD8_block16_x2_y7_patient388_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e2ca332127b198fa5b5ca40366dbfef56ba3be7 --- /dev/null +++ b/388/InvasionFront_CD8_block16_x2_y7_patient388_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5996.4, + "Centroid Y µm": 17042.4, + "Num Detections": 18421, + "Num Negative": 16757, + "Num Positive": 1664, + "Positive %": 9.033, + "Num Positive per mm^2": 727.08 + } +} \ No newline at end of file diff --git a/388/TumorCenter_CD3_block16_x1_y7_patient388_0.json b/388/TumorCenter_CD3_block16_x1_y7_patient388_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e275c0149a0ed36078b34b99ad9a1f7008164c6d --- /dev/null +++ b/388/TumorCenter_CD3_block16_x1_y7_patient388_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 17640.7, + "Num Detections": 12717, + "Num Negative": 8569, + "Num Positive": 4148, + "Positive %": 32.62, + "Num Positive per mm^2": 2383.3 + } +} \ No newline at end of file diff --git a/388/TumorCenter_CD3_block16_x2_y7_patient388_1.json b/388/TumorCenter_CD3_block16_x2_y7_patient388_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b491bc2932d9fb10b4027418beded0c0d0bf9c77 --- /dev/null +++ b/388/TumorCenter_CD3_block16_x2_y7_patient388_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6721.4, + "Centroid Y µm": 17915.5, + "Num Detections": 9853, + "Num Negative": 8111, + "Num Positive": 1742, + "Positive %": 17.68, + "Num Positive per mm^2": 1179.8 + } +} \ No newline at end of file diff --git a/388/TumorCenter_CD8_block16_x1_y7_patient388_0.json b/388/TumorCenter_CD8_block16_x1_y7_patient388_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ce535a926c77f7693f99421e9a97fc1d599b1dc2 --- /dev/null +++ b/388/TumorCenter_CD8_block16_x1_y7_patient388_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3373.2, + "Centroid Y µm": 18015.5, + "Num Detections": 14965, + "Num Negative": 11404, + "Num Positive": 3561, + "Positive %": 23.8, + "Num Positive per mm^2": 1835.7 + } +} \ No newline at end of file diff --git a/388/TumorCenter_CD8_block16_x2_y7_patient388_1.json b/388/TumorCenter_CD8_block16_x2_y7_patient388_1.json new file mode 100644 index 0000000000000000000000000000000000000000..506b308599c9e66a793384c8fb78d74c0a961289 --- /dev/null +++ b/388/TumorCenter_CD8_block16_x2_y7_patient388_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 17940.5, + "Num Detections": 10201, + "Num Negative": 9194, + "Num Positive": 1007, + "Positive %": 9.872, + "Num Positive per mm^2": 683.64 + } +} \ No newline at end of file diff --git a/388/history_text.txt b/388/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/388/icd_codes.txt b/388/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..40b19d25214baebef0a2dbb5db9d7cee53e1715e --- /dev/null +++ b/388/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Zungenrand[C02.1 ] \ No newline at end of file diff --git a/388/ops_codes.txt b/388/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e272f6c7d15f2c7451e9936ca9b8a70660eee2d8 --- /dev/null +++ b/388/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie[1-631 ] PEG-Sonde Anlage[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] \ No newline at end of file diff --git a/388/patient_clinical_data.json b/388/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b34a9f1cd5686f5bd1afe88c0561dcaf04a1a8b4 --- /dev/null +++ b/388/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 90, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 31, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/388/patient_pathological_data.json b/388/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..04c97447b3c6e9cd2b57bb7a5d6f61315d11a419 --- /dev/null +++ b/388/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "388", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 11.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/388/surgery_description.txt b/388/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d4051b58091d5cf56ba64900e04f4171d5cb3f6 --- /dev/null +++ b/388/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy, Neck dissection, PEG placement diff --git a/388/surgery_report.txt b/388/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..63026b348e2ec9111cfcc641cd32067f7caa59b9 --- /dev/null +++ b/388/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and nasal intubation by the anesthesia colleagues, the Kleinsasser tube is inserted. An exophytic tumor measuring approx. 3 x 1 cm was found on the right edge of the tongue in the posterior part. Palpatory identification of the deep extension. Mirroring to the oropharynx, here inconspicuous mucosal conditions on all sides, also in the hypopharynx, piriform sinus can be freely unfolded on both sides, glottic plane free, also the interary region, postcricoid region and posterior pharyngeal wall. Enter with the esophagogastroscope. In the esophagus, the mucosa is normal on all sides, no evidence of tumor growth. Mirroring forward to the stomach, no tumor growth here either. Air insufflation and diaphanoscopy. Subsequent placement of the PEG tube according to the thread pull-through method in the typical manner. Withdrawal of the esophagogastroscope. Insertion of the mouth blocker and placement of a retaining suture on the tongue. Pulling out the tongue. Defining the resection margins with the electric knife and successive excision of the tumor with careful hemostasis and bipolar coagulation. Intraoperative demonstration of findings on . Suture marking of the specimen and sending the specimen in toto for frozen section diagnostics. It is found to be tumor-free with a sufficient safety margin. Once again careful hemostasis with Octenisept swab application and bipolar coagulation. Now turn first to neck dissection on the right: sterile draping of the patient. Curved skin incision on the anterior edge of the sternocleidomastoid, separation of the platysma. Exposure of the anterior margin of the sternocleidomastoid. Exposure of the digastric muscle. Identification of the accessorius nerve, which is rather weakly developed. Exposure of the cervical vascular sheath with internal jugular vein, common carotid artery, identification of the vagus nerve. Successive exposure of the internal jugular vein from caudal to cranial. Now carefully detach the lateral neck preparation while protecting the plexus branches. At least 2 conspicuous nodes from level 2 are removed. Now expose the submandibular gland, follow the facial vein, this results in a vein tear, therefore ligation of the facial vein. Identification of the hypoglossal nerve and protection of the same. Now successive removal of the anterior neck preparation while sparing the structures mentioned. Careful hemostasis with bipolar coagulation. Wound irrigation using hydrogen and Ringer's solution. Insertion of a Redon drain. Subcutaneous suture. Skin suture. Turning to the left side of the neck. Here too, curved skin incision on the anterior edge of the sternocleidomastoid muscle, separation of the platysma, exposure of the anterior edge of the sternocleidomastoid muscle, exposure of the digastric muscle, exposure of the submandibular gland, identification of the hypoglossal nerve. Now explore the cervical vascular sheath, revealing an internal jugular vein located very far laterally next to the common carotid artery. Identification of the vagus nerve, protection of the structures mentioned. Free preparation of the facial vein. Identification of the accessorius nerve. The accessorius nerve is also rather weak on this side. Now successive detachment of the lateral neck preparation while sparing the plexus branches. Then release the anterior neck preparation while protecting the structures mentioned. Careful hemostasis with bipolar coagulation. Wound irrigation using hydrogen and Ringer's solution. Insertion of a Redon drainage. Subcutaneous suture. Skin suture. Now return to the edge of the tongue wound. Once again careful hemostasis with bipolar coagulation. Application of Tabotamp and adaptation of the wound edges as far as possible to prevent bleeding. Re-inspection of the base of the tongue, no relevant swelling is seen here. The operation is therefore completed without bleeding and without complications. \ No newline at end of file diff --git a/389/InvasionFront_CD3_block8_x1_y7_patient389_0.json b/389/InvasionFront_CD3_block8_x1_y7_patient389_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4afaa3570983fcfd69c1ca750f0f4550b0dd8cd8 --- /dev/null +++ b/389/InvasionFront_CD3_block8_x1_y7_patient389_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 27935.2, + "Num Detections": 19037, + "Num Negative": 15934, + "Num Positive": 3103, + "Positive %": 16.3, + "Num Positive per mm^2": 1277.6 + } +} \ No newline at end of file diff --git a/389/InvasionFront_CD3_block8_x2_y7_patient389_1.json b/389/InvasionFront_CD3_block8_x2_y7_patient389_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e8d08aee50f7f1880310b3eb7351a8abfd505183 --- /dev/null +++ b/389/InvasionFront_CD3_block8_x2_y7_patient389_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 27910.2, + "Num Detections": 20277, + "Num Negative": 18624, + "Num Positive": 1653, + "Positive %": 8.152, + "Num Positive per mm^2": 651.47 + } +} \ No newline at end of file diff --git a/389/InvasionFront_CD8_block8_x1_y7_patient389_0.json b/389/InvasionFront_CD8_block8_x1_y7_patient389_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c64b6df41e29e8d78abd8ba55c5d5df4603d517a --- /dev/null +++ b/389/InvasionFront_CD8_block8_x1_y7_patient389_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 17315.8, + "Num Detections": 17659, + "Num Negative": 15662, + "Num Positive": 1997, + "Positive %": 11.31, + "Num Positive per mm^2": 836.39 + } +} \ No newline at end of file diff --git a/389/InvasionFront_CD8_block8_x2_y7_patient389_1.json b/389/InvasionFront_CD8_block8_x2_y7_patient389_1.json new file mode 100644 index 0000000000000000000000000000000000000000..02710753d82881b6f89b9bfe93ef7588b881c8b1 --- /dev/null +++ b/389/InvasionFront_CD8_block8_x2_y7_patient389_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6671.5, + "Centroid Y µm": 17515.7, + "Num Detections": 20018, + "Num Negative": 18991, + "Num Positive": 1027, + "Positive %": 5.13, + "Num Positive per mm^2": 406.54 + } +} \ No newline at end of file diff --git a/389/TumorCenter_CD3_block8_x1_y7_patient389_0.json b/389/TumorCenter_CD3_block8_x1_y7_patient389_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c6b600e6997629c99b94fe45280ad4ed07d94e6c --- /dev/null +++ b/389/TumorCenter_CD3_block8_x1_y7_patient389_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4972.4, + "Centroid Y µm": 19289.8, + "Num Detections": 15850, + "Num Negative": 13715, + "Num Positive": 2135, + "Positive %": 13.47, + "Num Positive per mm^2": 1027.5 + } +} \ No newline at end of file diff --git a/389/TumorCenter_CD3_block8_x2_y7_patient389_1.json b/389/TumorCenter_CD3_block8_x2_y7_patient389_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5f005702e307076441e83156fc7cce7a7afebba1 --- /dev/null +++ b/389/TumorCenter_CD3_block8_x2_y7_patient389_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7471.0, + "Centroid Y µm": 19064.9, + "Num Detections": 15492, + "Num Negative": 13769, + "Num Positive": 1723, + "Positive %": 11.12, + "Num Positive per mm^2": 856.17 + } +} \ No newline at end of file diff --git a/389/TumorCenter_CD8_block8_x1_y7_patient389_0.json b/389/TumorCenter_CD8_block8_x1_y7_patient389_0.json new file mode 100644 index 0000000000000000000000000000000000000000..701f523f56d771cac762afd17f35204ffbf7bdf2 --- /dev/null +++ b/389/TumorCenter_CD8_block8_x1_y7_patient389_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4472.6, + "Centroid Y µm": 18565.2, + "Num Detections": 18641, + "Num Negative": 17765, + "Num Positive": 876, + "Positive %": 4.699, + "Num Positive per mm^2": 385.46 + } +} \ No newline at end of file diff --git a/389/TumorCenter_CD8_block8_x2_y7_patient389_1.json b/389/TumorCenter_CD8_block8_x2_y7_patient389_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4d5ade21c90cd4937f3ab2827934cb7efc020c2c --- /dev/null +++ b/389/TumorCenter_CD8_block8_x2_y7_patient389_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 18390.3, + "Num Detections": 18862, + "Num Negative": 17696, + "Num Positive": 1166, + "Positive %": 6.182, + "Num Positive per mm^2": 538.93 + } +} \ No newline at end of file diff --git a/389/history_text.txt b/389/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..da8a7d75a4dc24f0123dee8503eff72a14a30064 --- /dev/null +++ b/389/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed invasive carcinoma cT2 anterior floor of mouth area and carcinoma in situ with microinvasion in the palatal arch/pharyngeal side wall area on the right and carcinoma in situ in the area of the pocket crease on the left. The above-mentioned surgery is now indicated. \ No newline at end of file diff --git a/389/icd_codes.txt b/389/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fc4908f1c0348c96f7fb8bb786efeea5a9b4e5a --- /dev/null +++ b/389/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Mundboden mehrere Teilbereiche überlappend[C04.8 ] Carcinoma in situ des Oropharynx[D00.0 ] Carcinoma in situ des Larynx[D02.0 ] \ No newline at end of file diff --git a/389/ops_codes.txt b/389/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3421f58a488079218969bb011710f9aef7cbd9dd --- /dev/null +++ b/389/ops_codes.txt @@ -0,0 +1 @@ +Tumorentfernung Mundboden[5-273.x B] Sonstige Exzision und Destruktion erkranktes Gewebe Pharynx[5-292.x ] Endoskopische Laserresektion am Larynx[5-302.5 ] Permanente Tracheotomie[5-312.0 ] Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Sonstige Resektion Mundboden mit plastischer Rekonstruktion Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-277.x2 ] Resektion Mundboden mit Resektion Mandibula partiell ohne Kontinuitätsdurchtrennung sonstige[5-277.2x ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] \ No newline at end of file diff --git a/389/patient_clinical_data.json b/389/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..95407d5b2eb98062aeaa0f3176116ebc50afd135 --- /dev/null +++ b/389/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 56, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 35, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/389/patient_pathological_data.json b/389/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..78302c957d3c5e6860da4064813cfa7594c0eab2 --- /dev/null +++ b/389/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "389", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/389/surgery_description.txt b/389/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..019d9de78bdb4a00ad2efb61639d02469a204484 --- /dev/null +++ b/389/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection diff --git a/389/surgery_report.txt b/389/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1c2fe36bd6de6719c0935138837f4720e3cd9b15 --- /dev/null +++ b/389/surgery_report.txt @@ -0,0 +1 @@ +: PEG placement: supine position, positioning of the head. Enter with the laryngoscope blade and adjust the esophageal inlet. Then insertion of the flexible oesophagoscope and pre-scanning into the stomach. The esophagus is completely unremarkable. Further inspection of the stomach and pylorus including inversion. Unremarkable conditions on all sides. A PEG tube was then inserted using the thread pull-through method. There was a good diaphanoscopy. Tracheotomy: First injection of suprarenin/ultracaine mixture. Then sterile washing and draping. Palpation of the cricoid cartilage, thyroid cartilage and trachea. Curved skin incision between the cricoid cartilage and jugulum. Dissection in depth down to the musculature. Expose the midline and push the muscles sideways. Insertion of a retractor and exposure of the thyroid gland. This is relatively large and covered by very thick veins. Dissection of the upper and lower thyroid poles. Undermining of the thyroid gland. Then entering with Kocher clamps and clamping of the thyroid gland on both sides. Separation of the isthmus. Bipolar coagulation beforehand. Ligation of both thyroid lobes and exposure of the trachea. Now insertion between the 2nd and 3rd tracheal cartilage. Pushing these tracheal cartilages apart. The creation of a Björk flap is deliberately avoided as this tracheostoma is not intended to be permanent. Epithelialization of the skin in the sense of a visor tracheostomy. Insertion of an 8 mm Woodbridge tube. Skin suture at the lateral edges. Neck dissection on the right: Curved skin incision 2 cm below the mandible and T-shaped extension on the anterior edge of the sternocleidomastoid, this skin incision was previously discussed with . Dissection of the platysma and exposure of the anterior edge of the sternocleidomastoid. Locate and expose the omohyoid. Insertion of a retractor. Then exploration of the submandibular gland. Locate the cervical vascular sheath. Finding and exposing the accessorius nerve. Then exploration of the digaster muscle. Finding and exposing the hypoglossal nerve. Then start of neck dissection with free dissection of the internal jugular vein from caudal to cranial, then transition to level IIb and clearing of this level while sparing the accessorius nerve. Then evacuation of levels III and IV while sparing the plexus branches. Level V is not evacuated. Evacuation of level IIa and level Ib as well as Ia, initially leaving the submandibular gland intact, which is later removed by as part of the anastomosis. Exposure of all relevant vessels, external jugular vein, facial vein, superior thyroid artery, facial artery in preparation for the anastomosis. Neck dissection left: Curved skin incision 2 cm below the lower jaw, then T-shaped extension on the anterior edge of the sternocleidomastoid muscle. Separation of the platysma. Exposure of the anterior border of the sternocleidomastoid muscle, exposure of the omohyoid muscle, exposure of the submandibular gland, which is enlarged and hardened and looks tumorously altered. Involvement of who evacuates level Ib including the submandibular gland and level Ia and creates a tunnel to the opposite side as well as an opening in the floor of the mouth enorally in order to pass the flap through here later. Now expose the internal jugular vein and locate the accessorius nerve, which is unusually deep and runs dorsal to the internal jugular vein. Clearing out levels IIb, IIa, III and IV while sparing the plexus branches. Then exposure of the vessels, external jugular vein, facial vein, superior thyroid artery. Hemostasis on both sides by means of bipolar coagulation and insertion of Redon drains. Resection of the palatal arch tumor on the right: On the anterior palatal arch with transition to the soft palate, there is a tumorous change that appears to be finely bumpy on the outside and does not infiltrate into the depths. First mark the edges of the incision with the monopolar, starting at the base of the uvula in the soft palate, past the alveolar ridge of the maxilla, taking the glossotonsillar fold with it. Now start resecting the soft palate with scissors and, if necessary, bipolar forceps. The mucosa with underlying tissue is resected without completely removing the soft palate. Then removal of the glossotonsillar fold. Removal of the tonsil and a tongue base. Hemostasis using bipolar coagulation. The specimen is sent to histology marked with a thread. The pathologist was also able to detect carcinoma in situ in the frozen section medially on the soft palate. Therefore, a good ˝ cm was resected here again and then a marginal sample from this area was sent laterally to the frozen section with suture marking. This frozen section of the marginal sample was then tumor-free. Hemostasis by means of bipolar coagulation. : First transoral tumor resection: Initial oral floor resection: positioning of the head. Insertion of the mouth retractor. Tongue tie suture. Removal of the floor of mouth tumor, which is located in the anterior floor of the mouth and extends to the alveolar ridge. The tumor is incised with a safety margin of at least 1 cm on all sides. The periosteum is pushed away from the anterior bone. The muscles of the floor of the mouth are resected anteriorly if the growth appears to be deeper. Ductus Wharton is resected anteriorly on both sides. Removal of the tumor specimen and suture marking. Small focal infiltrates in the right tumor margin and at the junction of the alveolar ridge in the frozen section. Also carcinoma in situ in the area dorsal to the tongue. Therefore, another resection of a 1 cm wide resection dorsally towards the tongue and a wide resection laterally on the right up to the alveolar ridge. Due to the tumor resection, resection of the entire alveolar mucosa in the area of the incisors and canines as well as the first anterior molar is now indicated. These teeth must therefore be removed, which is done without complications. The entire alveolar ridge mucosa is then resected over the alveolar ridge. The mucosa is sent in with suture markings remote from the tumor. Similarly, marginal samples are sent in laterally on the right and dorsally from the tongue. No more tumor in the marginal specimens, thus R0 resection in the floor of the mouth. To confirm this, the bone in the anterior area is drilled back towards the alveoli with the large diamond drill, the alveoli are also drilled out and all mucosal parts are removed or drilled out. Then resection of the palatal/oropharyngeal sidewall carcinoma on the right (already included in the dictation by ). R0 resection at the end here too. Then laser resection of the carcinoma in situ of the left pocket fold: Insertion of the size C small bore tube. Exposure of the left pocket fold. A small bumpy area can be seen in which the preliminary biopsy was probably taken. This area is cut around broadly with a safety distance using the C02 laser 3 watt continuous wave with some soft tissue basally. The specimen is thread-marked and sent for frozen section. The frozen section shows carcinoma in situ infiltrates in the center, but peripherally free, thus also an R0 situation in the laryngeal region. Overall, R0 resection in all 3 resected tumors. Neck dissection on both sides and tracheotomy now follows. (already included in the dictation of ). Subsequent removal of the radial flap: the defect in the floor of the mouth is carefully measured beforehand. A flap with a maximum length of 9.5 cm and a maximum width of 6.5 cm is created. This is measured according to the defect. The defect is marked on the forearm in the appropriate size and shape. Then apply a tourniquet. Elevation of the flap first from the ulnar, then from the radial subfascial. Incision curved towards the crook of the elbow. Exposure of the superficial venous system. Exposure of the flap pedicle and brachioradialis muscle. Successive elevation of the radial flap. Distal exposure of the radial artery, here ligation with 4-0 Prolene. Successive elevation of the flap under its pedicle, smaller, outgoing vessels are supplied bipolar or closed with clips. The ulnar, interosseous and radial arteries can be visualized in the elbow area, as can the deep venous system and the connection to the superficial venous system. There are 2 larger veins here which can be used as an anastomosis. Deposition of the flap on 2 veins and 1 artery. Very good re-perfusion after opening the tourniquet. Sufficiently long re-perfusion time. The flap is then placed on the veins and the artery. The veins are ligated and the artery is supplied with a 4-0 Prolene puncture ligature. The flap is then rinsed with heparin solution. The flap is then sutured into the defect in the floor of the mouth: a wide tunnel is created from the left, through which the stalk is passed and brought over to the right side. The flap is successively sutured into the defect according to its shape and extent. Tension-free, complete defect coverage. Flap pedicle is passed through the tunnel to the right side. The veins and the artery are conditioned here. The superior thyroid artery is selected and conditioned as the anastomotic vessel. Suture to the radial artery with 8-0 Ethilon single-button sutures. After opening the clamps, good arterial flow and good venous return. Subsequent suturing of the cephalic vein to a terminal branch of the facial vein, which was previously prepared and conditioned. This is done with a size 3.5 coupler. The second venous vessel is then anastomosed to another small vein using a size 2.5 coupler. Good venous return and positive smear phenomenon in each case. Overall good flap perfusion, good arterial flow and good venous return. Careful irrigation of the wound area and hemostasis. Wound closure of each side of the neck and insertion of a Redon drain, which was fixed separately on the right side. Flap perfusion good to the end. A piece of full-thickness skin is now removed from the right groin in the typical manner. This is thinned out. After mobilization of the skin, the groin is closed in several layers with the insertion of a Redon drain. After thinning, the skin is inserted into the defect and sutured in place without tension. The cranial wound towards the elbow was closed in several layers in the typical manner. Subsequent application of a hydrogel-Mepilex dressing, loose application of compresses. Absorbent cotton dressing. Wrapping of the hand in the appropriate position on a Kramer splint using an elastic bandage. Hand is and was well supplied with blood at all times. The procedure was completed without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue antibiotics for 1 week, which had already been started intraoperatively. Flap control for 5 days according to the scheme using Doppler and clinically. Heparin perfusor 500 units/hour for 5 days. Feeding via PEG tube for 7 to 10 days. After that, diet build-up. Radiochemotherapy appears to be indicated for a total of 3 tumors and a bilateral N+ situation. Presentation in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/390/InvasionFront_CD3_block4_x1_y2_patient390_0.json b/390/InvasionFront_CD3_block4_x1_y2_patient390_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1fa165bd04e953fc0b127b6a067642a3498daee7 --- /dev/null +++ b/390/InvasionFront_CD3_block4_x1_y2_patient390_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6877.7, + "Centroid Y µm": 11604.8, + "Num Detections": 18773, + "Num Negative": 18177, + "Num Positive": 596, + "Positive %": 3.175, + "Num Positive per mm^2": 276.11 + } +} \ No newline at end of file diff --git a/390/InvasionFront_CD3_block4_x2_y2_patient390_1.json b/390/InvasionFront_CD3_block4_x2_y2_patient390_1.json new file mode 100644 index 0000000000000000000000000000000000000000..74ae4525271f2346b7019c04ffbbe28259db41ec --- /dev/null +++ b/390/InvasionFront_CD3_block4_x2_y2_patient390_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9475.7, + "Centroid Y µm": 11654.2, + "Num Detections": 23245, + "Num Negative": 21394, + "Num Positive": 1851, + "Positive %": 7.963, + "Num Positive per mm^2": 742.82 + } +} \ No newline at end of file diff --git a/390/InvasionFront_CD8_block4_x1_y2_patient390_0.json b/390/InvasionFront_CD8_block4_x1_y2_patient390_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9a046ec265157750380201c65605051f44c3fbfa --- /dev/null +++ b/390/InvasionFront_CD8_block4_x1_y2_patient390_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4226.1, + "Centroid Y µm": 9872.4, + "Num Detections": 19456, + "Num Negative": 19108, + "Num Positive": 348, + "Positive %": 1.789, + "Num Positive per mm^2": 151.12 + } +} \ No newline at end of file diff --git a/390/InvasionFront_CD8_block4_x2_y2_patient390_1.json b/390/InvasionFront_CD8_block4_x2_y2_patient390_1.json new file mode 100644 index 0000000000000000000000000000000000000000..98562436241df4f4defe6ba2bd2dc9da83daf5b0 --- /dev/null +++ b/390/InvasionFront_CD8_block4_x2_y2_patient390_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6836.2, + "Centroid Y µm": 9945.9, + "Num Detections": 23010, + "Num Negative": 20531, + "Num Positive": 2479, + "Positive %": 10.77, + "Num Positive per mm^2": 982.44 + } +} \ No newline at end of file diff --git a/390/TumorCenter_CD3_block4_x1_y2_patient390_0.json b/390/TumorCenter_CD3_block4_x1_y2_patient390_0.json new file mode 100644 index 0000000000000000000000000000000000000000..02d42673a32b6b0d117eef40afd19c4c23bfcd89 --- /dev/null +++ b/390/TumorCenter_CD3_block4_x1_y2_patient390_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3798.0, + "Centroid Y µm": 5022.3, + "Num Detections": 17805, + "Num Negative": 17082, + "Num Positive": 723, + "Positive %": 4.061, + "Num Positive per mm^2": 330.8 + } +} \ No newline at end of file diff --git a/390/TumorCenter_CD3_block4_x2_y2_patient390_1.json b/390/TumorCenter_CD3_block4_x2_y2_patient390_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6745a1cf0ff3aa890ba26ec20437916c3592456 --- /dev/null +++ b/390/TumorCenter_CD3_block4_x2_y2_patient390_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 5147.3, + "Num Detections": 19272, + "Num Negative": 17943, + "Num Positive": 1329, + "Positive %": 6.896, + "Num Positive per mm^2": 603.61 + } +} \ No newline at end of file diff --git a/390/TumorCenter_CD8_block4_x1_y2_patient390_0.json b/390/TumorCenter_CD8_block4_x1_y2_patient390_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f614aaae2cbb7e3a63d7b7d36f96d97382b6921e --- /dev/null +++ b/390/TumorCenter_CD8_block4_x1_y2_patient390_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5022.3, + "Centroid Y µm": 4722.5, + "Num Detections": 18376, + "Num Negative": 18032, + "Num Positive": 344, + "Positive %": 1.872, + "Num Positive per mm^2": 159.3 + } +} \ No newline at end of file diff --git a/390/TumorCenter_CD8_block4_x2_y2_patient390_1.json b/390/TumorCenter_CD8_block4_x2_y2_patient390_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4350bc075ca8592e9ca634565c4847464c8232a5 --- /dev/null +++ b/390/TumorCenter_CD8_block4_x2_y2_patient390_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7571.0, + "Centroid Y µm": 4922.4, + "Num Detections": 20424, + "Num Negative": 19712, + "Num Positive": 712, + "Positive %": 3.486, + "Num Positive per mm^2": 323.99 + } +} \ No newline at end of file diff --git a/390/history_text.txt b/390/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e503b77ddef5510db97c8e5c6a5f96207fa73080 --- /dev/null +++ b/390/history_text.txt @@ -0,0 +1 @@ +History of size-progressive cervical mass on the left. Suspicion of tonsillar carcinoma on the left as part of the ENT mirror examination. There is now an indication for panendoscopy and histological confirmation. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/390/icd_codes.txt b/390/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eea8583c2896d83437fc46838a3cfc7af2ea242f --- /dev/null +++ b/390/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Gaumenbogentonsillen[C09.1 L] \ No newline at end of file diff --git a/390/ops_codes.txt b/390/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2ee8ddb87c07381e6f2356f1eb36db94d296c908 --- /dev/null +++ b/390/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Transorale Tumortonsillektomie[5-281.2 ] \ No newline at end of file diff --git a/390/patient_clinical_data.json b/390/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a7898a4e566a386b7f228992a24ccab6c2f09573 --- /dev/null +++ b/390/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 0, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/390/patient_pathological_data.json b/390/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..47c250f86bac1b8a5f9633ff8eb7e317878aaab3 --- /dev/null +++ b/390/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "390", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 52, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/390/surgery_description.txt b/390/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..587927f219cb39f573a75a2a8991f579c9828368 --- /dev/null +++ b/390/surgery_description.txt @@ -0,0 +1 @@ +Panendoscopy, Excisional biopsy of left tonsil in the context of a tumor tonsillectomy diff --git a/390/surgery_report.txt b/390/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0ce511145e1849e82f89a82f8b7b41ee5cd8153a --- /dev/null +++ b/390/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesia colleagues. Induction of anesthesia and transition to rigid tracheoscopy. Problem-free passage of the glottis and endotracheal entry. The mucosal conditions are inconspicuous on all sides up to the exit of the segmental bronchi. The endoscope is then removed and the patient intubated by the surgeon. Transition to esophagogastroscopy. Insertion of the endoscope under visualization and constant air insufflation into the stomach. A slightly erosively altered gastric mucosal relief can be seen here. Inspection of the corpus fundus antrum and pylorus. Entering the inversion. Inspection of the gastroesophageal junction. Here refluxy change. Desufflation slow withdrawal of the endoscope with circular inspection of all esophageal sections. There is no evidence of a synchronous second tumor. Remove the endoscope and position the patient in head reclination. Insert a compress to protect the alveolar ridge. Enter with the size C small bore tube. First, adjust the endolarynx. This is unremarkable. Then inspect the hypopharynx, the postcricoid region and the esophageal entrance. The mucosal conditions are unremarkable on all sides. The same applies to the base of the tongue. The supraglottic region as well as the oral cavity and oral vestibule. Only in the area of the left tonsil is there a superficially growing, circumscribed exophytic change extending from the middle to the caudal left tonsil pole. The borders of the tonsil are respected both by inspection and palpation. In summary, CT1- maximum CT2 tonsillar carcinoma on the left is suspected. Since the tumor is strictly limited to the tonsil, the decision is now made to perform an excision biopsy in the sense of a tumor tonsillectomy. To do this, first grasp the tonsil and medialize it. Incision of the mucosa close to the uvula, exposing the tonsil capsule. Successive dissection along the capsule in the area of the cranial part. In the middle and caudal sections, part of the palatal arch muscles of the anterior and posterior palatal arch are also resected in order to ensure a sufficient safety margin. After caudal dissection into the base of the tongue. Macroscopically, the tumor was resected in toto. Suture marking of the tumor resectate and sending for frozen section diagnostics. Cis-like changes can still be seen in the area of the anterior palatal arch. The tumor is resected again and the resectate is sent in for frozen section diagnostics. R0 situation at the end of the operation. Hemostasis using bipolar coagulation. Dry wound conditions at the end of the operation. Final consultation with anesthesia colleagues. Removal of the mouth blocker and completion of the operation without complications. Conclusion: suspected CT1-2 tonsillar carcinoma on the left. Neck dissection on the left side and, if necessary, PEG insertion must now be planned in a two-stage procedure. \ No newline at end of file diff --git a/391/InvasionFront_CD3_block11_x3_y2_patient391_0.json b/391/InvasionFront_CD3_block11_x3_y2_patient391_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5b3a9a2ee006e07096b446b996e93f0cebb6d067 --- /dev/null +++ b/391/InvasionFront_CD3_block11_x3_y2_patient391_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10244.6, + "Centroid Y µm": 4897.4, + "Num Detections": 20798, + "Num Negative": 18227, + "Num Positive": 2571, + "Positive %": 12.36, + "Num Positive per mm^2": 1081.4 + } +} \ No newline at end of file diff --git a/391/InvasionFront_CD3_block11_x4_y2_patient391_1.json b/391/InvasionFront_CD3_block11_x4_y2_patient391_1.json new file mode 100644 index 0000000000000000000000000000000000000000..66ace982202b29beca64692441c45a3e512630c8 --- /dev/null +++ b/391/InvasionFront_CD3_block11_x4_y2_patient391_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 4997.4, + "Num Detections": 20742, + "Num Negative": 19491, + "Num Positive": 1251, + "Positive %": 6.031, + "Num Positive per mm^2": 499.83 + } +} \ No newline at end of file diff --git a/391/InvasionFront_CD8_block11_x3_y2_patient391_0.json b/391/InvasionFront_CD8_block11_x3_y2_patient391_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30721d771189907896c634d74e0fa90eba3948a5 --- /dev/null +++ b/391/InvasionFront_CD8_block11_x3_y2_patient391_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13749.0, + "Centroid Y µm": 15323.5, + "Num Detections": 20345, + "Num Negative": 17879, + "Num Positive": 2466, + "Positive %": 12.12, + "Num Positive per mm^2": 1090.6 + } +} \ No newline at end of file diff --git a/391/InvasionFront_CD8_block11_x4_y2_patient391_1.json b/391/InvasionFront_CD8_block11_x4_y2_patient391_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2482ecc7ccb2efb5c06047c0fd28e766cdd06729 --- /dev/null +++ b/391/InvasionFront_CD8_block11_x4_y2_patient391_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16336.1, + "Centroid Y µm": 15424.0, + "Num Detections": 19281, + "Num Negative": 18542, + "Num Positive": 739, + "Positive %": 3.833, + "Num Positive per mm^2": 308.83 + } +} \ No newline at end of file diff --git a/391/TumorCenter_CD3_block11_x3_y2_patient391_0.json b/391/TumorCenter_CD3_block11_x3_y2_patient391_0.json new file mode 100644 index 0000000000000000000000000000000000000000..26f4613b814f31f5de572bbde85698a5631efe0b --- /dev/null +++ b/391/TumorCenter_CD3_block11_x3_y2_patient391_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14767.2, + "Centroid Y µm": 4747.5, + "Num Detections": 14145, + "Num Negative": 14030, + "Num Positive": 115, + "Positive %": 0.813, + "Num Positive per mm^2": 52.66 + } +} \ No newline at end of file diff --git a/391/TumorCenter_CD3_block11_x4_y2_patient391_1.json b/391/TumorCenter_CD3_block11_x4_y2_patient391_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fa196c8589a0c0912d43821648f939fd30c82032 --- /dev/null +++ b/391/TumorCenter_CD3_block11_x4_y2_patient391_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17215.9, + "Centroid Y µm": 5022.3, + "Num Detections": 18987, + "Num Negative": 17331, + "Num Positive": 1656, + "Positive %": 8.722, + "Num Positive per mm^2": 726.46 + } +} \ No newline at end of file diff --git a/391/TumorCenter_CD8_block11_x3_y2_patient391_0.json b/391/TumorCenter_CD8_block11_x3_y2_patient391_0.json new file mode 100644 index 0000000000000000000000000000000000000000..564c91318de875c0409cd63205ffd93514538692 --- /dev/null +++ b/391/TumorCenter_CD8_block11_x3_y2_patient391_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12093.6, + "Centroid Y µm": 4822.4, + "Num Detections": 5816, + "Num Negative": 5789, + "Num Positive": 27, + "Positive %": 0.4642, + "Num Positive per mm^2": 36.97 + } +} \ No newline at end of file diff --git a/391/TumorCenter_CD8_block11_x4_y2_patient391_1.json b/391/TumorCenter_CD8_block11_x4_y2_patient391_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f446882c56096b66232e21695a367479cfce180c --- /dev/null +++ b/391/TumorCenter_CD8_block11_x4_y2_patient391_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14617.3, + "Centroid Y µm": 4947.4, + "Num Detections": 19931, + "Num Negative": 17792, + "Num Positive": 2139, + "Positive %": 10.73, + "Num Positive per mm^2": 932.23 + } +} \ No newline at end of file diff --git a/391/history_text.txt b/391/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..9bcc80aa04aaf924acbb5e91c1b0cf8502c2415c --- /dev/null +++ b/391/history_text.txt @@ -0,0 +1 @@ +Patient with confirmed HBV 16-positive carcinoma in the area of the tonsil lobe on the right, therefore the above-mentioned operation was indicated. Panendoscopy revealed transoral resectability without the need for flap coverage. \ No newline at end of file diff --git a/391/icd_codes.txt b/391/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2770660c26e82cc7a5e928e61e1ef4528738e535 --- /dev/null +++ b/391/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Fossa tonsillaris[C09.0 ] \ No newline at end of file diff --git a/391/ops_codes.txt b/391/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7b1a5a29cc2c3fd0bd247d52cf70c86f2d78c574 --- /dev/null +++ b/391/ops_codes.txt @@ -0,0 +1 @@ +Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Diagnostische ÖGD[1-632 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 L] \ No newline at end of file diff --git a/391/patient_clinical_data.json b/391/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cf02ccd1c8edc5c4582ecf573736df525b716a18 --- /dev/null +++ b/391/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 18, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/391/patient_pathological_data.json b/391/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..70798bacfcd75f5ac347841d8d1ee82ca33ba348 --- /dev/null +++ b/391/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "391", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 46, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Acantholytic", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/391/surgery_description.txt b/391/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1d5c31adb642010f3f4f08dbacc54e7964314133 --- /dev/null +++ b/391/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, PEG placement, Neck dissection diff --git a/391/surgery_report.txt b/391/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..16bea3dd27cc9decbcd5b66a9e3982e5d3bc2c8f --- /dev/null +++ b/391/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy again: The tumor is visible, which is essentially limited to the tonsillar lobe or just exceeds it at ........ This is followed by transoral tumor resection: The tumor is removed macroscopically on all sides with a safety margin of approx. 1 cm in healthy tissue. Parts of the pharyngeal musculature are resected as well as parts of the base of the tongue. The specimen is marked for frozen section. Tumor-free at all edges, minimally approx. 3 mm even in the shrunken state, thus R0 resection. This is followed by PEG insertion: insertion of the flexible esophagoscope into the stomach. Insertion of a 15 mm abdominal wall tube in the typical manner without any problems. Fixation to the abdominal wall. Subsequent repositioning for neck dissection on both sides, beginning with neck dissection on the right: here, a 4 cm large lymph node metastasis in level 2 cranial was already diagnosed sonographically. This is followed by the skin incision in front of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and the digastric muscle. Exposure of the cervical vascular sheath, internal jugular vein, internal carotid artery, external carotid artery and vagus nerve. Visualization of the anterior hypoglossal nerve, cranially the metastasis is visible, which is connected to the surrounding soft tissue. Detachment of the accessorius nerve is difficult. Infiltration in particular. Here with resection of the nerve for oncological reasons. Then develop the lateral neck preparation while exposing and preserving the branches of the cervical plexus. Then development of the anterior neck preparation with visualization and preservation of the hypoglossal nerve and superior thyroid artery. This results in a level 2-5 evacuation on the right side. Neck dissection on the left. Operators: , alternating Slightly curved incision cervically on the left along the anterior border of the sternocleidomastoid muscle, cutting through the subcutaneous tissue, the platysma, exposing the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid and digaster muscle, exposure of the accessorius nerve. A conglomerate of lymph nodes is visible in the region of region 2a, highly visible. This is carefully removed while protecting the above-mentioned structures. Exposure of the cervical vascular sheath. Dissection along the internal jugular vein from caudal to cranial. Dissection and removal of the posterior neck preparation. Exposure of the hypoglossal nerve, preparation and separation of the anterior neck preparation. Hemostasis using bipolar coagulation. Irrigation of the wound with hydrogen peroxide and Ringer's solution. Repeated inspection. Placement of a 10-gauge Redon drain. Two-layer wound closure. Completion of the procedure. \ No newline at end of file diff --git a/392/InvasionFront_CD3_block18_x1_y4_patient392_0.json b/392/InvasionFront_CD3_block18_x1_y4_patient392_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3ef92eaa2662d0b721797ae36e6dc7be00c747ad --- /dev/null +++ b/392/InvasionFront_CD3_block18_x1_y4_patient392_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 13892.6, + "Num Detections": 13676, + "Num Negative": 9562, + "Num Positive": 4114, + "Positive %": 30.08, + "Num Positive per mm^2": 2370.4 + } +} \ No newline at end of file diff --git a/392/InvasionFront_CD3_block18_x2_y4_patient392_1.json b/392/InvasionFront_CD3_block18_x2_y4_patient392_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c4c2cae9584d88f008edfe9a08d8e3149412ff31 --- /dev/null +++ b/392/InvasionFront_CD3_block18_x2_y4_patient392_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6721.4, + "Centroid Y µm": 14442.4, + "Num Detections": 6134, + "Num Negative": 5293, + "Num Positive": 841, + "Positive %": 13.71, + "Num Positive per mm^2": 679.5 + } +} \ No newline at end of file diff --git a/392/InvasionFront_CD8_block18_x1_y4_patient392_0.json b/392/InvasionFront_CD8_block18_x1_y4_patient392_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b405e9c2a3b06d4ef8ef323b5db3b0fea518cf5e --- /dev/null +++ b/392/InvasionFront_CD8_block18_x1_y4_patient392_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4272.7, + "Centroid Y µm": 17615.7, + "Num Detections": 17104, + "Num Negative": 13018, + "Num Positive": 4086, + "Positive %": 23.89, + "Num Positive per mm^2": 1941.2 + } +} \ No newline at end of file diff --git a/392/InvasionFront_CD8_block18_x2_y4_patient392_1.json b/392/InvasionFront_CD8_block18_x2_y4_patient392_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2bc4fe020ef89d17628969d2475172f221c09241 --- /dev/null +++ b/392/InvasionFront_CD8_block18_x2_y4_patient392_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6846.4, + "Centroid Y µm": 17790.6, + "Num Detections": 15395, + "Num Negative": 11876, + "Num Positive": 3519, + "Positive %": 22.86, + "Num Positive per mm^2": 1778.1 + } +} \ No newline at end of file diff --git a/392/TumorCenter_CD3_block18_x1_y4_patient392_0.json b/392/TumorCenter_CD3_block18_x1_y4_patient392_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f79f412f905eafde0b73192380cb9d53c068f19a --- /dev/null +++ b/392/TumorCenter_CD3_block18_x1_y4_patient392_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3650.0, + "Centroid Y µm": 9565.6, + "Num Detections": 11480, + "Num Negative": 10618, + "Num Positive": 862, + "Positive %": 7.509, + "Num Positive per mm^2": 565.85 + } +} \ No newline at end of file diff --git a/392/TumorCenter_CD3_block18_x2_y4_patient392_1.json b/392/TumorCenter_CD3_block18_x2_y4_patient392_1.json new file mode 100644 index 0000000000000000000000000000000000000000..edc6fcfe1b63c648ad16729c470c1cf84523c386 --- /dev/null +++ b/392/TumorCenter_CD3_block18_x2_y4_patient392_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6191.2, + "Centroid Y µm": 9743.7, + "Num Detections": 14080, + "Num Negative": 12720, + "Num Positive": 1360, + "Positive %": 9.659, + "Num Positive per mm^2": 758.26 + } +} \ No newline at end of file diff --git a/392/TumorCenter_CD8_block18_x1_y4_patient392_0.json b/392/TumorCenter_CD8_block18_x1_y4_patient392_0.json new file mode 100644 index 0000000000000000000000000000000000000000..28a4a4fa84880108e9632dc25413b7f62d0c0fa0 --- /dev/null +++ b/392/TumorCenter_CD8_block18_x1_y4_patient392_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 10369.5, + "Num Detections": 15219, + "Num Negative": 13270, + "Num Positive": 1949, + "Positive %": 12.81, + "Num Positive per mm^2": 949.22 + } +} \ No newline at end of file diff --git a/392/TumorCenter_CD8_block18_x2_y4_patient392_1.json b/392/TumorCenter_CD8_block18_x2_y4_patient392_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2330c476336911d550b7b787c5aa745f141a5c23 --- /dev/null +++ b/392/TumorCenter_CD8_block18_x2_y4_patient392_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 10419.5, + "Num Detections": 16046, + "Num Negative": 12128, + "Num Positive": 3918, + "Positive %": 24.42, + "Num Positive per mm^2": 1850.3 + } +} \ No newline at end of file diff --git a/392/history_text.txt b/392/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..8887be9402f6a7bf47f353c1474b1c1aaa81875e --- /dev/null +++ b/392/history_text.txt @@ -0,0 +1 @@ +The patient has had progressive hoarseness for almost 2 years. There is a suspicious mass supraglottic on the left side in the arytenoid region, which extends over the entire fold and vocal fold into the anterior commissure, passes from the anterior commissure to the right side and extends here to just in front of the arytenoid. Histologically squamous cell carcinoma. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/392/icd_codes.txt b/392/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fc6fd121dc40d22b6fb46d31a947332bc01b0c9d --- /dev/null +++ b/392/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Larynx, mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/392/ops_codes.txt b/392/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a019f769ce3bc3ffa0ba7407b6d30b5ff92155d7 --- /dev/null +++ b/392/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] \ No newline at end of file diff --git a/392/patient_clinical_data.json b/392/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2f915f424535a4290b26670811ac4a06a7bab415 --- /dev/null +++ b/392/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/392/patient_pathological_data.json b/392/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e7a0613451be3a64075e9ae72ceac5d9ada3ff3d --- /dev/null +++ b/392/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "392", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 21, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.6", + "histologic_type": null, + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/392/surgery_description.txt b/392/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ab581ffc9ccc517b3e02358b08cab8a025849aa6 --- /dev/null +++ b/392/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Tracheotomy, Provox insertion diff --git a/392/surgery_report.txt b/392/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed40a495437c5af8e762d57ed4de679668f938eb --- /dev/null +++ b/392/surgery_report.txt @@ -0,0 +1 @@ +Enter with 0° optics, then transnasal intubation. Tracheoscopy shows that the tumor extends far to the subglottic side and completely infiltrates the subglottic slope on both sides. Then enter with the small bore tube and inspect the tumor again as described above. Sterile washing and draping. Creation of an apron flap in the usual manner. Neck dissection on the left side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Visualization of the accessorius and hypoglossus. Exposure of the cervical vascular sheath. Clearing of levels II a to V a while sparing the plexus branches. Turning to the opposite side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Showing the accessorius and hypoglossus. Exposure of the cervical vascular sheath and clearing of the neck levels II a to V a while sparing the plexus branches. Release of the hyoid bone. Detachment of the oblique laryngeal muscles. Detachment of the thyroid gland. Exposure of the anterior wall of the trachea. Performing a tracheotomy between the 3rd and 4th tracheal cartilage. Release of the piriform sinus on both sides. Entering the pharynx from the right. Disluxation of the epiglottis. Detachment of the larynx from the pharyngeal mucosa. Separation of the larynx between the 3rd and 4th tracheal cartilage. Removal of marginal samples, 1x from the posterior and anterior tracheal wall and pharyngeal side wall on both sides. All edge samples in the frozen section completely free. Overall R0 situation in the frozen section. Then perform the esophageal myotomy on the left side. Insertion of a Provox-Vega prosthesis in the usual manner. Then start with the pharyngeal suture in three layers in the usual manner. Insertion of Redon drains and two-layer wound closure. \ No newline at end of file diff --git a/393/InvasionFront_CD3_block9_x3_y1_patient393_0.json b/393/InvasionFront_CD3_block9_x3_y1_patient393_0.json new file mode 100644 index 0000000000000000000000000000000000000000..71a09340c11fab6a70ecc054c96dab823cad3d3b --- /dev/null +++ b/393/InvasionFront_CD3_block9_x3_y1_patient393_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 2948.4, + "Num Detections": 24904, + "Num Negative": 23506, + "Num Positive": 1398, + "Positive %": 5.614, + "Num Positive per mm^2": 513.9 + } +} \ No newline at end of file diff --git a/393/InvasionFront_CD3_block9_x4_y1_patient393_1.json b/393/InvasionFront_CD3_block9_x4_y1_patient393_1.json new file mode 100644 index 0000000000000000000000000000000000000000..74940323277a87bd01d2c5343cb118ac7f6a1c70 --- /dev/null +++ b/393/InvasionFront_CD3_block9_x4_y1_patient393_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 3248.3, + "Num Detections": 23305, + "Num Negative": 21698, + "Num Positive": 1607, + "Positive %": 6.896, + "Num Positive per mm^2": 596.61 + } +} \ No newline at end of file diff --git a/393/InvasionFront_CD8_block9_x3_y1_patient393_0.json b/393/InvasionFront_CD8_block9_x3_y1_patient393_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42eef9e61c79d9ba032f1375bbaccf46381fcdf4 --- /dev/null +++ b/393/InvasionFront_CD8_block9_x3_y1_patient393_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13043.1, + "Centroid Y µm": 7396.1, + "Num Detections": 24281, + "Num Negative": 21839, + "Num Positive": 2442, + "Positive %": 10.06, + "Num Positive per mm^2": 936.53 + } +} \ No newline at end of file diff --git a/393/InvasionFront_CD8_block9_x4_y1_patient393_1.json b/393/InvasionFront_CD8_block9_x4_y1_patient393_1.json new file mode 100644 index 0000000000000000000000000000000000000000..af3d86ea0476f6ccec29ee68b9fe50f39f2b7c90 --- /dev/null +++ b/393/InvasionFront_CD8_block9_x4_y1_patient393_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15541.8, + "Centroid Y µm": 7546.0, + "Num Detections": 23755, + "Num Negative": 21473, + "Num Positive": 2282, + "Positive %": 9.606, + "Num Positive per mm^2": 884.47 + } +} \ No newline at end of file diff --git a/393/TumorCenter_CD3_block9_x3_y1_patient393_0.json b/393/TumorCenter_CD3_block9_x3_y1_patient393_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c42f85f055bf4d5b6ae911d0d59c717e141eedf5 --- /dev/null +++ b/393/TumorCenter_CD3_block9_x3_y1_patient393_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11893.7, + "Centroid Y µm": 8070.7, + "Num Detections": 22878, + "Num Negative": 19335, + "Num Positive": 3543, + "Positive %": 15.49, + "Num Positive per mm^2": 1287.2 + } +} \ No newline at end of file diff --git a/393/TumorCenter_CD3_block9_x4_y1_patient393_1.json b/393/TumorCenter_CD3_block9_x4_y1_patient393_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6600880519fa21ff69bb914f9d6e1abee61a388 --- /dev/null +++ b/393/TumorCenter_CD3_block9_x4_y1_patient393_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14517.3, + "Centroid Y µm": 8195.7, + "Num Detections": 20170, + "Num Negative": 18783, + "Num Positive": 1387, + "Positive %": 6.877, + "Num Positive per mm^2": 528.54 + } +} \ No newline at end of file diff --git a/393/TumorCenter_CD8_block9_x3_y1_patient393_0.json b/393/TumorCenter_CD8_block9_x3_y1_patient393_0.json new file mode 100644 index 0000000000000000000000000000000000000000..268e99e897fcf2094e3a3f824a52c4944dd1adfd --- /dev/null +++ b/393/TumorCenter_CD8_block9_x3_y1_patient393_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10894.2, + "Centroid Y µm": 2973.4, + "Num Detections": 23346, + "Num Negative": 19834, + "Num Positive": 3512, + "Positive %": 15.04, + "Num Positive per mm^2": 1290.8 + } +} \ No newline at end of file diff --git a/393/TumorCenter_CD8_block9_x4_y1_patient393_1.json b/393/TumorCenter_CD8_block9_x4_y1_patient393_1.json new file mode 100644 index 0000000000000000000000000000000000000000..923c262fceff666fd0bad16d6e244abf25b58bae --- /dev/null +++ b/393/TumorCenter_CD8_block9_x4_y1_patient393_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 2923.5, + "Num Detections": 20180, + "Num Negative": 18881, + "Num Positive": 1299, + "Positive %": 6.437, + "Num Positive per mm^2": 496.85 + } +} \ No newline at end of file diff --git a/393/history_text.txt b/393/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c82ec38ccecc47a6e3bf56282088ae41715ae5b4 --- /dev/null +++ b/393/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma. Described in the pre-endoscopy as a carcinoma in the oropharynx and hypopharynx. Now after interdisciplinary tumor conference above mentioned intervention indicated. \ No newline at end of file diff --git a/393/icd_codes.txt b/393/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..787cfb96793c7bc866ad1cd744c23567db3dd1be --- /dev/null +++ b/393/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 ] Neubildung bösartig Hypopharynx sonstige[C13.8 ] \ No newline at end of file diff --git a/393/ops_codes.txt b/393/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4bc1bfb8d18f043a3e103ffb196242e958af0228 --- /dev/null +++ b/393/ops_codes.txt @@ -0,0 +1 @@ +Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Temporäre Tracheotomie[5-311.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.x4 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] sonstige[5-296.0x ] Großflächige freie Spalthauttransplantation am Unterarm[5-902.48 R] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 R] Wechsel vaskuläres Implantat[5-394.3 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] PEG-Sonde Anlage[5-431.2 ] \ No newline at end of file diff --git a/393/patient_clinical_data.json b/393/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9e82e81c568d0a4bae2d8e13e57a641cde4b3d4e --- /dev/null +++ b/393/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 36, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/393/patient_pathological_data.json b/393/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ddbb46deb5b7b970ae235082c86b20e489e3f0eb --- /dev/null +++ b/393/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "393", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 37, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/393/surgery_description.txt b/393/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0d8e223131c695c837392fa47c8794fe7b601c0 --- /dev/null +++ b/393/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Free flap (Radial), Tracheotomy diff --git a/393/surgery_report.txt b/393/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..436d74bcfa1b5e08113c92819e10935d057d22f0 --- /dev/null +++ b/393/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngo- and laryngoscopy again: The exophytic tumor is seen with deep crater formation in the area of the palatal arch up to the uvula, growth on the posterior side of the palatal arch and towards the nasopharynx, growth deep into the soft tissues towards the pharyngeal wall and mandible, growth up to the base of the tongue via the lateral oropharyngeal wall and into the hypopharynx. Larynx itself not involved by macroscopically visible tumor. Confirmation of the indication for surgery. Now PEG placement, neck dissection and tracheostoma placement. These surgical steps are dictated by . First placement of a PEG tube. This is carried out without complications using the thread pull-through method with adequate diaphanoscopy in the typical manner. A neck dissection is then performed on the right side. Creation of a skin incision along the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Dissection of the platysma. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure in the depth of the nervus accessorius, the omohyoid muscle and the posterior venter of the digaster muscle. Dissection along the cervical vascular sheath. Exposure and sparing of the vagus nerve and the common carotid artery. Removal of the neck specimen posteriorly while sparing the above-mentioned structures. Protection of the deep plexus branches. Hemostasis using bipolar coagulation. Subsequent removal of the anterior neck preparation. Hemostasis using bipolar coagulation. Wound irrigation using hydrogen peroxide and Ringer's solution. Placement of a 10 Redon drain. Two-layer wound closure. Now repositioning of the patient to perform a neck dissection on the left side. Creation of a skin incision along the anterior edge of the sternocleidomastoid muscle. Cut through the skin, the subcutaneous tissue and the platysma. Exposure and dissection along the anterior border of the sternocleidomastoid muscle. Exposure of the accessorius nerve, the posterior venter of the digaster muscle, the omohyoid muscle and the capsule of the submandibular gland, which is removed in the preparation. Exposure and protection of the cervical vascular sheath. Removal of the posterior neck specimen while preserving the above-mentioned structures and the plexus branches. Removal of the anterior neck specimen. Hemostasis using bipolar coagulation. Placement of a 10 Redon drain and two-layer wound closure and completion of the neck dissection on the left side. A tracheotomy is then performed in the typical manner. Creation of a skin incision directly below the level of the cricoid cartilage, approx. 3 cm long. Cut through the subcutaneous tissue. Exposure of the prelaryngeal musculature. Exposure of the thyroid isthmus. Undermining of the thyroid isthmus using Pean clamps. Dissection of the thyroid isthmus and ligation of both thyroid stumps. Exposure of the anterior wall of the trachea. Creation of a tracheal incision between the 2nd and 3rd tracheal cartilage clasp using a scalpel. Creation of a Björk flap in the typical manner and epithelization of the tracheostoma. Reintubation to a size 8 Rügheim tracheostomy tube. Completion of the procedure without complications. Subsequent combined transcervical, transoral tumor resection: First, all vessels, internal jugular vein, internal and external carotid artery and all cranial nerves including vagus nerve, hypoglossal nerve and glossopharyngeal nerve are severed from the pharyngeal wall to the base of the skull and marked with vessel loops. Detachment of the tumor from the spinal column, which is successful with a blunt approach, no infiltrations visible here. Then cut around the tumor from the transoral side with a safety margin of at least 1.5 to 2 cm on all sides. The entire palatal arch falls down to the uvula, leaving the remaining palatal arch on the left. The soft palate is resected, as well as the posterior side up to the nasopharynx, taking the tube partially with it. Push off the soft tissue under control from the outside to just in front of the lower jaw. Co-resection of the pharyngeal wall and the pterygoid muscles. Detachment of the tumor also from the transoral and cranial side of the spinal column. Large parts of the posterior pharyngeal wall are also resected. The tumor is resected from the transcervical side in the tongue base area, whereby almost half of the tongue base area with vallecula and parts of the lateral epiglottis as well as parts of the hyoid bone are also resected. The resection extends into the piriform sinus and includes parts of the lateral laryngeal area including parts of the thyroid cartilage from the mucosa to the arytenoid fold. However, arytenoid cartilage is preserved. Vallecula parts are resected up to the middle. The entire specimen is removed and marked using several sutures. In addition, marginal samples are taken caudally from the posterior pharyngeal wall, from the piriform sinus up to the arytenoid fold, basally from the base of the tongue with soft tissue and mucosa, a marginal sample basally caudally, a marginal sample from the lateral epiglottis and a marginal sample from the posterior wall of the palatine arch at the transition to the nasopharynx. The specimen as a whole is in situ, as are the marginal samples, i.e. R0 situation. The defect includes the piriform sinus, lateral oropharyngeal side wall, palatal arch, posterior pharyngeal wall, base of tongue and vallecula. Defect is measured three-dimensionally. Irrigation of the wound area with H2O2 and Ringer's solution and careful hemostasis. The dimensions and size of the defect are recorded on the right forearm, flap size max. 16 cm in length and just under 10 cm in width. Now flap removal: first cut around the flap ulnarly subfascially. Extend the incision into the crook of the elbow. Subsequent exposure of the radial artery. This is initially clamped for 15 to 20 minutes. ........... Incision of the flap also from radial subfascial. Ramus cutaneus antebrachii is preserved as far as possible. The superficial venous system is exposed and also elevated. Exposure of the vascular pedicle under the brachioradialis muscle. Exposure of the connection between the superficial and deep venous system. Now expose the radial artery. This is relatively deep. Pulse oximeter always at 100% after clamping, no special features or abnormalities. 100% saturation even after clamping until the end of the operation. Successive lifting of the flap subfascially. Outgoing smaller vessels are clipped or bipolar coagulated. Lift the flap with the superficial vein system and pedicle up to the antecubital fossa. Two branches from the cephalic vein can be dissected here as connecting veins. The radial artery can also be dissected up to just before the brachial artery entrance. Also a venous confluence. The interosseous artery was cut and ligated. The flap was then removed. The edge of the radial antebrachial artery is treated with Prolene 4-0 puncture ligatures. The veins are ligated. Flap vessels are flushed with heparin. A piece of full-thickness skin of the appropriate size is removed from the groin. This is conditioned and incorporated into the forearm defect. The cranial defect is closed in layers. A hydrogel-Mepilex dressing and a swab dressing are applied, wrapping with sterile absorbent cotton, application of a Kramer splint and wrapping of the arm with an elastic bandage, application of the arm. Blood circulation always ensured. Now insert the flap into the defect. Gradual incorporation of the flap. The palatal arch area can be effectively replaced, as can all anatomical regions. Only in the cranial area of the posterior wall is complete defect coverage not possible, here not only a double but a triple fold would have to be made, which does not appear to be technically possible. To secure the nasopharyngeal passage, a gastric tube is inserted during flap insertion and the position is also successfully checked. Suturing is performed with 3-0 Vicryl single button sutures, partly from the transoral and partly from the transcervical side, partly also after the insertion of sutures. The result is a tension-free and complete closure of the defect, whereby, as described, the most cranial parts of the posterior pharyngeal wall are not covered. There is still muscle and fascia on the spine. The vessels on the flap and in the neck area are then conditioned. The superior thyroid artery is selected, which is connected to the radial artery in 8-0 single button sutures. After opening the clamp, good arterial flow, good venous return. Subsequent conditioning of the veins. It can be seen that a vein can still be used at the internal jugular artery. However, it is also apparent that the internal jugular vein is partially thrombosed due to insufficient flow. Opening of the vein, thrombus can be expressed, after which flow is possible again. Due to the fact that there are no other veins left and the stalk cannot be passed through to the left side due to the shortness of the stalk relative to the required distance, the largest cephalic vein is now connected to the facial vein using a 3-0 coupler. Good flow after opening, also positive smear phenomenon. No further signs of thrombosis in the further course, so that here, with probably a lack of return flow from the cerebrum, the return flow from the flap appears to counteract further thrombosis. Other veins are clipped. Enoral flap control brings good conditions. Irrigation of the entire wound area. Careful hemostasis. Wound closure in layers with insertion of a Redon drain on both sides, guided on the right. Completion of the procedure without complications. Patient transferred to the intensive care unit for postoperative monitoring. Please continue heparin perfusor, which was started intraoperatively at 500 units per hour, for 5 days. Continue antibiotic treatment with Unacid, which was started preoperatively, for 1 week. Feeding via PEG for at least 10 days, then gruel and, if necessary, slow, careful build-up of diet. Flap control according to the scheme for 5 days by means of Doppler and clinical checks. Position of the anastomosis or stalk marked with suture. Overall multistage carcinoma cT4 cN2c. Postoperative radiochemotherapy certainly indicated. Please discuss the procedure in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/394/InvasionFront_CD3_block14_x5_y1_patient394_0.json b/394/InvasionFront_CD3_block14_x5_y1_patient394_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e5dd50dd8867394e1a87dcea703d35053c4f7628 --- /dev/null +++ b/394/InvasionFront_CD3_block14_x5_y1_patient394_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17465.8, + "Centroid Y µm": 6321.7, + "Num Detections": 17865, + "Num Negative": 17375, + "Num Positive": 490, + "Positive %": 2.743, + "Num Positive per mm^2": 190.07 + } +} \ No newline at end of file diff --git a/394/InvasionFront_CD3_block14_x6_y1_patient394_1.json b/394/InvasionFront_CD3_block14_x6_y1_patient394_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5a73363b6601d8673e77dcea978e2d03ce220f7a --- /dev/null +++ b/394/InvasionFront_CD3_block14_x6_y1_patient394_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19989.4, + "Centroid Y µm": 6471.6, + "Num Detections": 20574, + "Num Negative": 19363, + "Num Positive": 1211, + "Positive %": 5.886, + "Num Positive per mm^2": 471.12 + } +} \ No newline at end of file diff --git a/394/InvasionFront_CD8_block14_x5_y1_patient394_0.json b/394/InvasionFront_CD8_block14_x5_y1_patient394_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4168228b91f85db1cb3c07322264494391ed105a --- /dev/null +++ b/394/InvasionFront_CD8_block14_x5_y1_patient394_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 2548.7, + "Num Detections": 16161, + "Num Negative": 16012, + "Num Positive": 149, + "Positive %": 0.922, + "Num Positive per mm^2": 62.54 + } +} \ No newline at end of file diff --git a/394/InvasionFront_CD8_block14_x6_y1_patient394_1.json b/394/InvasionFront_CD8_block14_x6_y1_patient394_1.json new file mode 100644 index 0000000000000000000000000000000000000000..182176dee01a3169233a0b604effd053d258f622 --- /dev/null +++ b/394/InvasionFront_CD8_block14_x6_y1_patient394_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19489.7, + "Centroid Y µm": 2523.7, + "Num Detections": 20281, + "Num Negative": 19885, + "Num Positive": 396, + "Positive %": 1.953, + "Num Positive per mm^2": 156.75 + } +} \ No newline at end of file diff --git a/394/TumorCenter_CD3_block14_x5_y1_patient394_0.json b/394/TumorCenter_CD3_block14_x5_y1_patient394_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f6b30cdf7bbef920a85ae9bc728b69ea2a7ff71c --- /dev/null +++ b/394/TumorCenter_CD3_block14_x5_y1_patient394_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17415.8, + "Centroid Y µm": 3348.2, + "Num Detections": 16509, + "Num Negative": 15828, + "Num Positive": 681, + "Positive %": 4.125, + "Num Positive per mm^2": 280.01 + } +} \ No newline at end of file diff --git a/394/TumorCenter_CD3_block14_x6_y1_patient394_1.json b/394/TumorCenter_CD3_block14_x6_y1_patient394_1.json new file mode 100644 index 0000000000000000000000000000000000000000..775a6107d2c96b668cb3f96e20ab4aff95b14cdb --- /dev/null +++ b/394/TumorCenter_CD3_block14_x6_y1_patient394_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19889.5, + "Centroid Y µm": 3548.1, + "Num Detections": 15799, + "Num Negative": 15547, + "Num Positive": 252, + "Positive %": 1.595, + "Num Positive per mm^2": 106.14 + } +} \ No newline at end of file diff --git a/394/TumorCenter_CD8_block14_x5_y1_patient394_0.json b/394/TumorCenter_CD8_block14_x5_y1_patient394_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a1ba4672e9f23f1305afcf9cd68c372415f92cc9 --- /dev/null +++ b/394/TumorCenter_CD8_block14_x5_y1_patient394_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 3473.2, + "Num Detections": 16386, + "Num Negative": 16247, + "Num Positive": 139, + "Positive %": 0.8483, + "Num Positive per mm^2": 58.55 + } +} \ No newline at end of file diff --git a/394/TumorCenter_CD8_block14_x6_y1_patient394_1.json b/394/TumorCenter_CD8_block14_x6_y1_patient394_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1e0eb2eb56f163ca372fc955d61dc4e74051b9e3 --- /dev/null +++ b/394/TumorCenter_CD8_block14_x6_y1_patient394_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 3498.1, + "Num Detections": 15048, + "Num Negative": 15021, + "Num Positive": 27, + "Positive %": 0.1794, + "Num Positive per mm^2": 11.34 + } +} \ No newline at end of file diff --git a/394/history_text.txt b/394/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7d2b31c899149fe05612c32326284117d14ac3ad --- /dev/null +++ b/394/history_text.txt @@ -0,0 +1 @@ +The patient presented with a swelling of the tongue that had been present for several months. There was also a weight loss of approx. 8 kg. Inspection revealed an exophytic mass on the left edge of the tongue, which also infiltrated the base of the tongue up to the midline on CT morphology. \ No newline at end of file diff --git a/394/icd_codes.txt b/394/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa53eb8be9331d2518fcb354f682f2ba6ca6ca6c --- /dev/null +++ b/394/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] Halslymphknotenmetastasen[C77.0 L] \ No newline at end of file diff --git a/394/ops_codes.txt b/394/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1f74c68b0d706f03f747cd1ca1fecae43620d06 --- /dev/null +++ b/394/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Ösophagoskopie[1-630.x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Partielle Glossektomie transoral Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.02 ] Transplantat[5-295.04 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige Spalthautdeckung am Unterarm[5-902.48 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/394/patient_clinical_data.json b/394/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f5f41e8135edf92a145babc9132a57bd33a55505 --- /dev/null +++ b/394/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 40, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/394/patient_pathological_data.json b/394/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c145a30af01d425eb84a3a031e4a4f593336ca54 --- /dev/null +++ b/394/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "394", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT3", + "pN_stage": "pN2c", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/394/surgery_description.txt b/394/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..94a8f298980a9ecb49321cd7151a10901822627d --- /dev/null +++ b/394/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Tracheotomy, Defect coverage, PEG placement diff --git a/394/surgery_report.txt b/394/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..02764051a5887d5ea78fdd7b498d335726924ca3 --- /dev/null +++ b/394/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and transnasal intubation by the anesthesia colleagues. First, the PEG is inserted. To do this, enter with the flexible esophagoscope and pre-scan into the stomach. No abnormalities here with good diaphanoscopy. Insertion of the PEG using the thread pull-through method through and . First, transoral tumor resection is performed after appropriate preparation. After insertion of the retractors, the tongue is disluxed and tumor resection begins with the monopolar caustic technique at an appropriate safety distance. Subsequently, marginal sections are taken from the entire circumference of the resulting defect and examined using frozen section histology, all of which prove to be tumor-free, so that an R0 resection can be assumed. Neck dissection then started on the left side: After skin incision, dissection and fixation of the skin platysma flap. Regions I-V are then removed while preserving all non-lymphatic structures. A passage is created from the transoral resection into the lateral neck. A large caliber jugular vein and the superior thyroid artery are dissected out for anasatomization. Then transition to neck dissection on the opposite side. Here too, all lymph node stations are removed while preserving all non-lymphatic structures. In the meantime, removal of the radialis graft and continuation of the operation by . starts lifting the radialis graft from the left forearm. Exposure of the brachioradialis muscle for this purpose. Exposure of the cephalic vein. Exposure of the venous star. Exposure of the venous confluence. Exposure of the radial artery at the exit from the brachial artery. Addition of and further preparation. Incision of the graft. Exposure of the cephalic vein in the distal area. Dissection of the cephalic vein so that it is still connected to the graft with subcutaneous tissue and can be virtually integrated. Exposure of the superficial ramus of the radial nerve, which has several branches, the branches of which can be preserved. Exposure of the radial artery. Separation of the radial artery and lifting of the graft. Dissection of the pedicle up to the elbow and removal of the graft, taking superficial and deep veins with it. Closure of the arm with split skin in the usual manner using and . Suturing of the graft combined transcervically and transorally. This succeeds without any problems. had already performed a primary suture in the area of the soft palate and the tonsil beforehand. This was completed and then the graft was sutured in place. Removal of the stalk to the left side of the neck. Anastomosis of the radial artery with the superior thyroid artery. Anastomosis of a deep vein to a branch from the facial vein close to the outlet and performance of an end-to-side anastomosis between the internal jugular vein and the point where the cephalic vein joins the venous confluence. Before the venous anastomosis, there was a very good venous return from the deep and also from the superficial system and explicitly also from the cephalic vein. Finally, positioning of the pedicle and inspection of the oral cavity. The graft is well supplied with blood. Puncture the graft, blood comes back. Palpation of the graft. The pulse of the radial artery can be felt. Please check the flap according to the usual procedure. Continue antibiotics for at least 24 hours. Post-operative blue swallow on the 10th day, an X-ray pre-swallow is not necessary. \ No newline at end of file diff --git a/395/InvasionFront_CD3_block17_x5_y10_patient395_0.json b/395/InvasionFront_CD3_block17_x5_y10_patient395_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6f218afcfa8bbea196c58e46632b5e57f2e7990c --- /dev/null +++ b/395/InvasionFront_CD3_block17_x5_y10_patient395_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 30284.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/InvasionFront_CD3_block17_x6_y10_patient395_1.json b/395/InvasionFront_CD3_block17_x6_y10_patient395_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ab70ca80822b3d4083dc3c71108ea9d90052abfe --- /dev/null +++ b/395/InvasionFront_CD3_block17_x6_y10_patient395_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18390.3, + "Centroid Y µm": 30333.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/InvasionFront_CD8_block17_x5_y10_patient395_0.json b/395/InvasionFront_CD8_block17_x5_y10_patient395_0.json new file mode 100644 index 0000000000000000000000000000000000000000..49192e7aafe47c1c61c99ab20bef1a07e9a6d829 --- /dev/null +++ b/395/InvasionFront_CD8_block17_x5_y10_patient395_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 25136.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/InvasionFront_CD8_block17_x6_y10_patient395_1.json b/395/InvasionFront_CD8_block17_x6_y10_patient395_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6b2531d1ec5327b9433c528afc265d3e8fe8fd68 --- /dev/null +++ b/395/InvasionFront_CD8_block17_x6_y10_patient395_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 25161.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/TumorCenter_CD3_block17_x5_y10_patient395_0.json b/395/TumorCenter_CD3_block17_x5_y10_patient395_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2c9ca4fbee993e03e23206c7ed6f88a4b3b86594 --- /dev/null +++ b/395/TumorCenter_CD3_block17_x5_y10_patient395_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15716.7, + "Centroid Y µm": 24986.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/TumorCenter_CD3_block17_x6_y10_patient395_1.json b/395/TumorCenter_CD3_block17_x6_y10_patient395_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6cb29dd9f5993b2e269ec8524e9398936375deb --- /dev/null +++ b/395/TumorCenter_CD3_block17_x6_y10_patient395_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18115.4, + "Centroid Y µm": 25036.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/TumorCenter_CD8_block17_x5_y10_patient395_0.json b/395/TumorCenter_CD8_block17_x5_y10_patient395_0.json new file mode 100644 index 0000000000000000000000000000000000000000..553eae4697c7fd05c02614acc92279c5edf1d2c9 --- /dev/null +++ b/395/TumorCenter_CD8_block17_x5_y10_patient395_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 38279.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/TumorCenter_CD8_block17_x6_y10_patient395_1.json b/395/TumorCenter_CD8_block17_x6_y10_patient395_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7aced05ee36b1889b92d8535b0b82d1b43f6e8f5 --- /dev/null +++ b/395/TumorCenter_CD8_block17_x6_y10_patient395_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21488.6, + "Centroid Y µm": 38229.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/395/history_text.txt b/395/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6932b9bd876f1768782239cef12796b2c11c14e7 --- /dev/null +++ b/395/history_text.txt @@ -0,0 +1 @@ +During a right hemithyroidectomy, the patient was found to have a suspicious lump alio loco in the area of the carotid bifurcation. This was extirpated during the same session. The external pathohistologic examination revealed a metastasis of a squamous cell carcinoma. In further external diagnostics, the primary tumor in the area of the lingual epiglottis on the right could then also be verified histologically. There is now an indication for transoral resection of the tumor and neck revision on the right side. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/395/icd_codes.txt b/395/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a3dbedb6140da1c80cc06d6b10669fa1480cb740 --- /dev/null +++ b/395/icd_codes.txt @@ -0,0 +1 @@ +Karzinom der Epiglottis[C32.1 R] Halslymphknotenmetastasen[C77.0 R] \ No newline at end of file diff --git a/395/ops_codes.txt b/395/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..77de52fc7e1369cf63c4e73ee22c1cfb6373a891 --- /dev/null +++ b/395/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R] Endoskopische Laserresektion Larynxgewebe[5-302.5 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] \ No newline at end of file diff --git a/395/patient_clinical_data.json b/395/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9ef7958eba2353683de9f478c9d8a789c0827023 --- /dev/null +++ b/395/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 71, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 79, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/395/patient_pathological_data.json b/395/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..698725dbdbb620e03b13174afcaa6ca45d369b09 --- /dev/null +++ b/395/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "395", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 11.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 1.5 +} \ No newline at end of file diff --git a/395/surgery_description.txt b/395/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..aa6600ac99c5d69c2130ed6cfae9c56178271908 --- /dev/null +++ b/395/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection, Right neck dissection, Panendoscopy diff --git a/395/surgery_report.txt b/395/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..808facf02abcac30ffa8623e3db6b175f4e5b821 --- /dev/null +++ b/395/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carry out the team time-out. Introductory consultation with the anesthesia colleagues. Induction of anesthesia and intubation of the patient. Transition to esophagogastroscopy. Insertion of the flexible endoscope under visualization and constant air insufflation into the stomach. A typical, non-irritating gastric mucosal relief is seen on all sides. Inversion and inspection of the gastroesophageal junction. This also appears unremarkable. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. There is no evidence of malignancy here. Remove the endoscope. Positioning of the patient in head reclination. Insertion of the mouth guard. Insertion with the size C small bore tube. First, adjust the endolarynx. This appears unremarkable. Inspection of the hypopharynx on both sides also reveals no evidence of malignancy. The tip of the piriform sinus can be freely unfolded on both sides and is lined with smooth mucosa on all sides. Postcricoid as well as in the area of the esophageal entrance are also unremarkable on all sides. The epiglottis is now adjusted. In the area of the lingual epiglottis on the right side, an area of uneven mucosa can be seen. There is no typical exophytic tumor growth here. Using the surgical microscope, it can be seen that the tumor-specific mucosal changes in the lingual epiglottis are strictly limited to the right side. The patient is now switched to a spread laryngoscope. With the addition of the support autoscope and the surgical microscope, the tumor is first cut around in a circle with the CO2 laser at a power of 5 watts. It can now be seen that the tumor is obviously infiltrating the cartilage centrally and also appears to be partially growing into the cartilage due to the cartilage fenestrations typical of the epiglottis. Hence the decision to perform a hemiepiglottiectomy. Further inspection also reveals a highly visible change in the mucosa in the area of the lateral free edge of the epiglottis up to just before the pharyngoepiglottic fold. Paramedian in the area of the plica glossoepiglottica mediana, the right part of the epiglottis is now resected up to the vallecula. Removal of a marginal sample in the area of the plica glossoepiglottica and in the area of the vallecula. In addition, removal of a marginal sample in the area of the pharyngoepiglottic fold. Sending in the tumor excidate as well as the marginal samples for frozen section diagnostics. This shows tumor-free marginal samples. Hemostasis is performed using the defocused laser and insertion of a suprarenin-soaked laryngeal swab. Subsequently, removal of the small drainage tube and the mouth guard. Repositioning for neck dissection. First, skin spray disinfection and infiltration anesthesia. Skin wipe disinfection and sterile draping. Creation of the skin incision running along the anterior edge of the sternocleidomastoid muscle. Sharp cutting of the cutis as well as the subcutis. Sharp transection of the platysma. Exposure of the anterior edge of the sternocleidomastoid muscle. Exposure and ligation of the external jugular vein. Exposure and protection of the auricular nerve. Turning to the cervical vascular sheath. Here it can be seen that the cervical vascular sheath is heavily scarred due to the previous procedure. Numerous metal clips are visible. First expose the caudal border in the area of the omohyoid muscle. Exposure of the cranial border in the sense of the posterior digastric venter muscle. There are no scars either far cranially or far caudally. Therefore, the internal jugular vein is shown caudally first. In addition, the cranial part of the internal jugular vein is shown at the level of the digastric muscle. The accessorius nerve is also exposed. This is followed by exposure of the common carotid artery, the bifurcation and the internal and external carotid artery. Exposure of the vagus nerve and free preparation of the same from a scar block. With great effort, the lateral neck preparation can now be successively developed. Shortly below the vein angle, a massive block of scar tissue is revealed with nodules inside, which can be identified by palpation. Successive detachment of the scar block from the internal jugular vein. This results in a tear of a larger outlet. As the vein was secured both cranially and caudally using vessel loops, the bleeding can be easily controlled. Clamping out the slit-shaped defect and suturing it over with Vascufil. A Tachosil fleece is also applied. Subsequently, successive development of the lateral neck preparation via levels II b, II a, III and IV. Then turn to the median neck preparation. First expose the hypoglossal nerve. Neurolysis of the same. Exposure and ligation of the facial vein, which is also largely fixed in a scar block. Then development of the median neck preparation and wound irrigation with H2O2 and Ringer's solution. Hemostasis using bipolar coagulation. Insertion of a 10 Redon drain. Subcutaneous suture with Vicryl 4.0 and skin suture with Ethilon 5.0. Application of a wound dressing. Final inspection of the laryngeal wound bed. There is no evidence of further bleeding. If the wound bed is dry, the operation is completed without complications. Final consultation with anesthesia colleagues. The operation is completed without complications. \ No newline at end of file diff --git a/396/InvasionFront_CD3_block20_x3_y11_patient396_0.json b/396/InvasionFront_CD3_block20_x3_y11_patient396_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a6ade471bff73e7b5f26b5aa9f2208096705e204 --- /dev/null +++ b/396/InvasionFront_CD3_block20_x3_y11_patient396_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 27010.7, + "Num Detections": 19013, + "Num Negative": 18631, + "Num Positive": 382, + "Positive %": 2.009, + "Num Positive per mm^2": 190.18 + } +} \ No newline at end of file diff --git a/396/InvasionFront_CD3_block20_x4_y11_patient396_1.json b/396/InvasionFront_CD3_block20_x4_y11_patient396_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1fb23d431b0887bbd8c231a10ad73c44dca6b48d --- /dev/null +++ b/396/InvasionFront_CD3_block20_x4_y11_patient396_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13592.8, + "Centroid Y µm": 27210.6, + "Num Detections": 18048, + "Num Negative": 17520, + "Num Positive": 528, + "Positive %": 2.926, + "Num Positive per mm^2": 250.55 + } +} \ No newline at end of file diff --git a/396/InvasionFront_CD8_block20_x3_y10_patient396_0.json b/396/InvasionFront_CD8_block20_x3_y10_patient396_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9283d1750b71b6020002420d190f1e4ebb339a6c --- /dev/null +++ b/396/InvasionFront_CD8_block20_x3_y10_patient396_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12343.5, + "Centroid Y µm": 25086.7, + "Num Detections": 13318, + "Num Negative": 12691, + "Num Positive": 627, + "Positive %": 4.708, + "Num Positive per mm^2": 330.2 + } +} \ No newline at end of file diff --git a/396/InvasionFront_CD8_block20_x4_y10_patient396_1.json b/396/InvasionFront_CD8_block20_x4_y10_patient396_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3e0108ead5a58810d0dde8d9f24023bcfb47ba1 --- /dev/null +++ b/396/InvasionFront_CD8_block20_x4_y10_patient396_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14865.4, + "Centroid Y µm": 24970.8, + "Num Detections": 16247, + "Num Negative": 16182, + "Num Positive": 65, + "Positive %": 0.4001, + "Num Positive per mm^2": 29.96 + } +} \ No newline at end of file diff --git a/396/TumorCenter_CD3_block20_x3_y10_patient396_0.json b/396/TumorCenter_CD3_block20_x3_y10_patient396_0.json new file mode 100644 index 0000000000000000000000000000000000000000..628ed5c061d499750f3cf1b9bb2923c917219720 --- /dev/null +++ b/396/TumorCenter_CD3_block20_x3_y10_patient396_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11152.5, + "Centroid Y µm": 23927.8, + "Num Detections": 4256, + "Num Negative": 4014, + "Num Positive": 242, + "Positive %": 5.686, + "Num Positive per mm^2": 120.28 + } +} \ No newline at end of file diff --git a/396/TumorCenter_CD3_block20_x4_y10_patient396_1.json b/396/TumorCenter_CD3_block20_x4_y10_patient396_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6e5d18bbfff4d03dea488343fc5ccb3253149b5e --- /dev/null +++ b/396/TumorCenter_CD3_block20_x4_y10_patient396_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13648.3, + "Centroid Y µm": 24046.0, + "Num Detections": 12069, + "Num Negative": 11989, + "Num Positive": 80, + "Positive %": 0.6629, + "Num Positive per mm^2": 39.83 + } +} \ No newline at end of file diff --git a/396/TumorCenter_CD8_block20_x3_y10_patient396_0.json b/396/TumorCenter_CD8_block20_x3_y10_patient396_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a741fcefc627530ee190a79a39a3c86f00966602 --- /dev/null +++ b/396/TumorCenter_CD8_block20_x3_y10_patient396_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11319.0, + "Centroid Y µm": 25136.7, + "Num Detections": 10843, + "Num Negative": 10476, + "Num Positive": 367, + "Positive %": 3.385, + "Num Positive per mm^2": 219.2 + } +} \ No newline at end of file diff --git a/396/TumorCenter_CD8_block20_x4_y10_patient396_1.json b/396/TumorCenter_CD8_block20_x4_y10_patient396_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b2f66c8f0e267c1b681bd8839486bf8d4b204c4 --- /dev/null +++ b/396/TumorCenter_CD8_block20_x4_y10_patient396_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 24911.8, + "Num Detections": 13504, + "Num Negative": 13248, + "Num Positive": 256, + "Positive %": 1.896, + "Num Positive per mm^2": 122.42 + } +} \ No newline at end of file diff --git a/396/history_text.txt b/396/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6b3a688fb21ea165def434f9a550b6a8c0eac095 --- /dev/null +++ b/396/history_text.txt @@ -0,0 +1 @@ +The patient has a cT4 supraglottic laryngeal carcinoma with complete displacement of the glottic plane. In this regard, a tracheotomy was performed in an emergency <2013>. At our interdisciplinary tumor conference, it was decided to perform a laryngectomy with neck dissection on both sides. Therefore indication for the above procedure. \ No newline at end of file diff --git a/396/icd_codes.txt b/396/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/396/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/396/ops_codes.txt b/396/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8ed741993f2c6e72b546962fd55096d4a574f4f7 --- /dev/null +++ b/396/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/396/patient_clinical_data.json b/396/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5fa78ce83b70eae39e00225c825c063e62adc90d --- /dev/null +++ b/396/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/396/patient_pathological_data.json b/396/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5764b22901d740b53b15dff8faec36721166f71f --- /dev/null +++ b/396/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "396", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 51, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/396/surgery_description.txt b/396/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..285b1ffdad4a90b4d5c5ff0b00b9cbe61cf5bcf4 --- /dev/null +++ b/396/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy with partial pharyngectomy diff --git a/396/surgery_report.txt b/396/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..664c992a2ed07462420b2c7af669655205697764 --- /dev/null +++ b/396/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia colleagues through the tracheostoma already in place, first renewed laryngoscopy and confirmation of tumor extension. Then infiltration anesthesia. Sterile wiping, draping. Curved skin incision that includes the old tracheostoma. Creation of an apron flap strictly subplatysmal. This works very well. First start with the neck dissection on the right side. Further dissection of the sternocleidomastoid anterior edge. Dissection along the muscle up to the posterior edge. Exposure of the omohyoid muscle, the digastric muscle and the accessorius nerve. These leading structures are spared during the entire operation. Exposure and dissection along the internal jugular vein and the facial vein. The structures are spared. Multiple lymph nodes are already present in this area, all of which are removed. After mobilization and exposure of the cervical vascular sheath with carotid and vagus, development of the lateral neck preparation. This is very successful. All plexus branches are spared. Now further dissect and develop the anterior neck preparation, including the capsule of the submandibular vein. Expose and protect the hypoglossal nerve and the digastric muscle. Bipolar hemostasis. Neck dissection on the left is performed in the same way. Here too, all important structures such as the internal jugular vein, facial vein, accessorius nerve, hypoglossal nerve and the cervical vascular sheath are exposed and spared. Dissection of the hyoid bone with dissection of the infrahyoid and suprahyoid muscles. Mobilization and retraction of the thyroid gland from the trachea. Successive skeletonization of the laryngeal skeleton and detachment of the prelaryngeal musculature. Exposure of the cornu majus on both sides. Careful, blunt dissection of the pharyngeal tube from the inner sides of the thyroid cartilage on both sides. Further inspection reveals that the tumor is growing into the soft tissue in the area of the hyoid bone on the right side. Entering the pharyngeal tube suprahyoidally. Inspection of the tumor. Here it can be seen that the tumor is occupying the entire laryngeal lumen and appears to be growing submucosally on the right side into the base of the tongue. A generous resection is now performed macroscopically far into the healthy tissue. Ultimately, the complete laryngeal preparation with the tumor can be pushed caudally. Separation of the esophagus from the trachea. The trachea is finally removed at the level of the previously created tracheostoma. This preparation is now sent for final histology. Generous marginal samples are taken from strategically important points and from the base of the tongue, parapharyngeal area on the right and suprahyoidal area on the right side. These are sent for frozen section and are found to be tumor-free on all sides. Careful pharyngeal suturing is now performed, paying particular attention to tension-free adaptation in the area of the base of the tongue. Multi-layer pharyngeal suture. Adaptation of the former prelaryngeal musculature over the pharyngeal suture. Overall, this results in at least three to four layers of closure in this area. Prior to this, a Provox prosthesis was inserted in the typical manner by the phoniatrics colleagues. Insertion of two Redon drains. Pushing back the apron flap. Readaptation in the area of the tracheostoma. Further two-layer wound closure. Application of a pressure bandage. Completion of the procedure without complications. Conclusion: Overall laryngectomy with neck dissection on both sides and placement of a Provox prosthesis for T4 supraglottic laryngeal carcinoma. X-ray pre-swallow recommended in 7-10 days, if the findings are normal, slow diet build-up. Further procedure depending on the histology at our interdisciplinary tumor conference. \ No newline at end of file diff --git a/397/InvasionFront_CD3_block2_x3_y6_patient397_0.json b/397/InvasionFront_CD3_block2_x3_y6_patient397_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d056b5d5f51cb7df98de0db21126b2bc7f3a32ab --- /dev/null +++ b/397/InvasionFront_CD3_block2_x3_y6_patient397_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13778.1, + "Centroid Y µm": 28287.5, + "Num Detections": 10480, + "Num Negative": 10285, + "Num Positive": 195, + "Positive %": 1.861, + "Num Positive per mm^2": 135.46 + } +} \ No newline at end of file diff --git a/397/InvasionFront_CD3_block2_x4_y6_patient397_1.json b/397/InvasionFront_CD3_block2_x4_y6_patient397_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2c57ac2e1ebd87219226c2431e908aa01d8ba475 --- /dev/null +++ b/397/InvasionFront_CD3_block2_x4_y6_patient397_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16266.4, + "Centroid Y µm": 28509.9, + "Num Detections": 16999, + "Num Negative": 16797, + "Num Positive": 202, + "Positive %": 1.188, + "Num Positive per mm^2": 97.25 + } +} \ No newline at end of file diff --git a/397/InvasionFront_CD8_block2_x3_y6_patient397_0.json b/397/InvasionFront_CD8_block2_x3_y6_patient397_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d01e2ab7e6677c480cefa12b77d4577e7160a655 --- /dev/null +++ b/397/InvasionFront_CD8_block2_x3_y6_patient397_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12393.4, + "Centroid Y µm": 15966.5, + "Num Detections": 12201, + "Num Negative": 12166, + "Num Positive": 35, + "Positive %": 0.2869, + "Num Positive per mm^2": 20.85 + } +} \ No newline at end of file diff --git a/397/InvasionFront_CD8_block2_x4_y6_patient397_1.json b/397/InvasionFront_CD8_block2_x4_y6_patient397_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c780a3d15588d5105a6efa60fd747ce4c1d1e9ed --- /dev/null +++ b/397/InvasionFront_CD8_block2_x4_y6_patient397_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15092.0, + "Centroid Y µm": 16191.4, + "Num Detections": 16425, + "Num Negative": 16365, + "Num Positive": 60, + "Positive %": 0.3653, + "Num Positive per mm^2": 28.97 + } +} \ No newline at end of file diff --git a/397/TumorCenter_CD3_block2_x3_y6_patient397_0.json b/397/TumorCenter_CD3_block2_x3_y6_patient397_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e80dbcf459bedfcd4ba7637f1366a6f3d93f9f67 --- /dev/null +++ b/397/TumorCenter_CD3_block2_x3_y6_patient397_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11443.9, + "Centroid Y µm": 14542.3, + "Num Detections": 14037, + "Num Negative": 13900, + "Num Positive": 137, + "Positive %": 0.976, + "Num Positive per mm^2": 72.1 + } +} \ No newline at end of file diff --git a/397/TumorCenter_CD3_block2_x4_y6_patient397_1.json b/397/TumorCenter_CD3_block2_x4_y6_patient397_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1c6e6bf7d75693a5a8191a6c95054ac540b318ac --- /dev/null +++ b/397/TumorCenter_CD3_block2_x4_y6_patient397_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13867.7, + "Centroid Y µm": 14792.2, + "Num Detections": 16677, + "Num Negative": 16420, + "Num Positive": 257, + "Positive %": 1.541, + "Num Positive per mm^2": 120.92 + } +} \ No newline at end of file diff --git a/397/TumorCenter_CD8_block2_x3_y6_patient397_0.json b/397/TumorCenter_CD8_block2_x3_y6_patient397_0.json new file mode 100644 index 0000000000000000000000000000000000000000..757d9e95a3458717fca7b773fbdd43be0e4e0138 --- /dev/null +++ b/397/TumorCenter_CD8_block2_x3_y6_patient397_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13168.0, + "Centroid Y µm": 14567.3, + "Num Detections": 12358, + "Num Negative": 12342, + "Num Positive": 16, + "Positive %": 0.1295, + "Num Positive per mm^2": 8.641 + } +} \ No newline at end of file diff --git a/397/TumorCenter_CD8_block2_x4_y6_patient397_1.json b/397/TumorCenter_CD8_block2_x4_y6_patient397_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8c3a9a27409ffd26da199e59207a8f14b513635a --- /dev/null +++ b/397/TumorCenter_CD8_block2_x4_y6_patient397_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15591.7, + "Centroid Y µm": 14642.2, + "Num Detections": 17577, + "Num Negative": 17548, + "Num Positive": 29, + "Positive %": 0.165, + "Num Positive per mm^2": 13.47 + } +} \ No newline at end of file diff --git a/397/history_text.txt b/397/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..fdb54a61b540e410cec2acadd92e7807c0a15d14 --- /dev/null +++ b/397/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the area of the left side of the tongue, left floor of the mouth, left base of the tongue, left tonsil lobe and left pharyngeal side wall. The above-mentioned surgery was therefore indicated. \ No newline at end of file diff --git a/397/icd_codes.txt b/397/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/397/ops_codes.txt b/397/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..89e46520b98fd0701135a12dd1dfe598c7d8b7f9 --- /dev/null +++ b/397/ops_codes.txt @@ -0,0 +1 @@ +Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Transplantat[5-295.04 ] Tumorentfernung Mundboden[5-273.x L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 R] Permanente Tracheotomie[5-312.0 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] Entnahme Spalthaut zur Transplantation Unterarm[5-901.08 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] \ No newline at end of file diff --git a/397/patient_clinical_data.json b/397/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6c857990903df3147de65ac58e3640207e348084 --- /dev/null +++ b/397/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 42, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 43, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/397/patient_pathological_data.json b/397/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..dfc399cde4d5c5920bd53ab53124567fb18041d9 --- /dev/null +++ b/397/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "397", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/397/surgery_description.txt b/397/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..9312f6430b7d43ccff033193ecac8eb99f4703a1 --- /dev/null +++ b/397/surgery_description.txt @@ -0,0 +1 @@ +PEG, Transoral and transcervical resection, Bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial) diff --git a/397/surgery_report.txt b/397/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0d7d76cd7dfce38543d736cc03245111d09b4dc7 --- /dev/null +++ b/397/surgery_report.txt @@ -0,0 +1 @@ +Total cT3 tumor. Midline of the tongue reached, but not crossed. Repeated pharyngoscopy and laryngoscopy as well as oral cavity inspection: confirmation of tumor extension. Correspondingly, another CT assessment. PEG placement is now performed first: insertion with the esophagoscope through the esophagus into the stomach. After establishing spontaneous diaphanoscopy, insertion of a 15 mm abdominal wall tube without any problems. Fixation to the abdominal wall. Then tumor resection: Start with transoral resection: visualization of the tumor. The tumor is incised macroscopically and palpated on all sides with a safety margin of at least 1-1.5 cm. The posterior 2/3 of the tongue is removed up to above the midline, in the tongue base area about half of the tongue base is removed. In the floor of the mouth, removal of all soft tissue up to the lower jaw including the lingual nerve. Glossoalveolar groove and tonsil are resected together with parts of the pharyngeal side wall, caudal to it. As the overview of the soft tissue extension dorso-caudally below the mandible is not quite sufficient, the decision was made to complete the resection from transcervical to neck dissection. Therefore, repositioning to complete the tumor resection and neck dissection on both sides. Injection of 10 ml Ultracaine 1% with adrenaline into each side of the neck. Marking of the required tracheostomy. Start with neck dissection on the left: Skin incision in typical manner. Exposure of the sternocleidomastoid muscle. Exposure of digastric muscle, omohyoid muscle and infrahoyidal muscles. Exposure of the submandibular gland, which is initially left in place. Evacuation of level II-V. Internal carotid artery, external carotid artery, internal jugular vein, facial vein and external jugular vein are exposed and preserved. The accessorius, hypoglossal and vagus nerves and the branches of the cervical plexus are also preserved. This results in a level II to V neck dissection. Subsequent completion of the tumor resection. For this purpose, the digastric and styloid muscles are severed. Dissection of the submandibular gland. This is removed with all attached soft tissue en bloc with the soft tissue in connection with the inner tumor preparation and pulled through transorally. The tumor preparation is thread-marked and sent for frozen section. All tumor margins free in the specimen. In the dorso-basal area at the transition from the body of the tongue to the base of the tongue, removal of the tumor bordering on the resection margins, therefore another slice of soft tissue is removed from this area, which is then sent for final diagnosis. Overall R0 situation. This is followed by neck dissection on the right side: This is performed by A. Dittberner. Evacuation of levels II to IV in a typical manner with exposure of the internal carotid artery, external carotid artery, superior thyroid artery. V. jugularis interna, externa. V. jugularis cannot be preserved due to a tear and is ligated. Exposure of the vagus nerve, hypoglossal nerve and accessorius nerve as well as the branches of the cervical plexus, all structures are preserved. This results in evacuation of levels II to IV. Cranially, the submandibular gland is exposed and preserved. Subsequent tracheostoma creation: small Kocher collar incision, exposure of subcutaneous tissue, platysma. Dissection through the infrahyoid muscles after spreading them in the linea alba. Exposure of the thyroid isthmus. This is passed underneath, clamped off, severed and supplied by means of puncture ligatures. Exposure of the trachea. Creation of a broadly pedicled Björk flap. This is epithelized in the typical manner. Re-intubation and insertion of a laryngectomy tube. Subsequent irrigation of all wound areas with hydrogen and Ringer's solution. Removal of the forearm flap: measurement of the demissions results in a flap length of 11-12 cm and a width of up to 7 cm. The flap is marked on the forearm in the required size and shape. First cut around the flap from the ulnar side. Extension of the incision into the crook of the elbow. Depiction of the superficial venous system. Incision of the flap from the radial side. Lifting of the flap from ulnar and radial subfascial. Distal clamping of the radial artery. Exposure of the pedicle with the radial artery and radial vein. Dissection up to the olecranon. Exposure of the connection between the superficial and deep venous system. Two outlets from the area of the cephalic vein can be visualized. An acceptable confluence in the area of the radial vein. The radial artery is then removed. This is treated with puncture ligatures 4-0 Prolene. Lift the flap subfascially along the pedicle, smaller branches are coagulated or glued bipolarly. Dissection up to the antecubital fossa. The interosseous artery is clamped for 10 minutes. Here too, as before clamping the radial artery, constant saturation above 100 %. Disconnect the interosseous artery. Then remove the flap. The brachial artery is treated with 6-0 Vascufil sutures. Here too, saturation at 100 %. The veins are clamped and ligated. Flap is removed and flushed with heparin solution. After careful hemostasis, the proximal part of the forearm is closed in layers. The forearm defect is covered with thick split skin 0.7-0.8 mm. For this purpose, split skin is removed from the right thigh with the dermatome. Suture the split skin into the forearm defect. Thigh is treated with hydrogel dressing. The forearm is treated with ..............-Mepilex dressing, with a loose swab dressing on top, which is modeled using absorbent cotton. Fitting of a cramp splint. This is loosely fixed with a tape bandage. Positioning of the arm. Subsequent suturing of the radial flap into the defect: After partial suturing, the flap is gradually worked into the defect. Tension-free suturing of the flap is achieved. The stem is inserted through the large tunnel into the soft tissues of the neck. Complete tension-free defect coverage. Vessels are conditioned. The radial artery is sutured to the superior thyroid artery after conditioning. For this purpose, fish-mouth-like dilation of the superior thyroid artery. Suture with Ethilon 9-0 sutures. After opening the previously inserted clamps, good arterial flow, good venous return. Both outlets of the cephalic vein are conditioned for the anastomosis. One outlet is anastomosed with an outlet from the facial vein after conditioning using a 2.5 mm coupler. After opening the clamp, there is no venous return. Positive smear phenomenon. The other outlet from the cephalic vein is anastomosed after conditioning with the external jugular vein using a 3.5 mm coupler. Here too, after opening the clamp, reflux without any problems, positive smear phenomenon. Subsequent clipping of the still open confluence. Irrigation of the entire neck area and careful hemostasis. Layered wound closure on the right with insertion of a Redon drain. Layered wound closure on the left with insertion of 2 flaps. Insertion of a tracheostomy tube, which is fixed with sutures. Tracheal cannula with size 8. Repeated inspection of the flap. This is vital. Completion of the procedure without complications. Patient has received Unacid several times intraoperatively. Please continue this antibiotic treatment for one week. Patient goes to intensive care unit for monitoring. Please elevate the patient's upper body. Flap control according to the scheme, clinically if necessary also with Doppler sonography control. Continue heparin which was started intraoperatively at 500 E/h for 5 days. Nutrition via the PEG tube. After 7-10 days, if necessary, swallow porridge and then build up diet. Post-ventilation for one night. Overall cT3 oral floor oropharyngeal carcinoma on the left. Lymph node status in any case cN2b, possibly also cN2c on the right with some enlarged lymph nodes. Further procedure after final histology, presentation at the interdisciplinary tumor conference. \ No newline at end of file diff --git a/398/InvasionFront_CD3_block10_x3_y7_patient398_0.json b/398/InvasionFront_CD3_block10_x3_y7_patient398_0.json new file mode 100644 index 0000000000000000000000000000000000000000..dcdccf35dd2e94f02e3c803f87e8ace55d5b12d0 --- /dev/null +++ b/398/InvasionFront_CD3_block10_x3_y7_patient398_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12893.2, + "Centroid Y µm": 23212.7, + "Num Detections": 19881, + "Num Negative": 16744, + "Num Positive": 3137, + "Positive %": 15.78, + "Num Positive per mm^2": 1337.1 + } +} \ No newline at end of file diff --git a/398/InvasionFront_CD3_block10_x4_y7_patient398_1.json b/398/InvasionFront_CD3_block10_x4_y7_patient398_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fea7ff2cb882fcce5c8cef4a66941a88042960af --- /dev/null +++ b/398/InvasionFront_CD3_block10_x4_y7_patient398_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15541.8, + "Centroid Y µm": 23112.8, + "Num Detections": 21935, + "Num Negative": 18105, + "Num Positive": 3830, + "Positive %": 17.46, + "Num Positive per mm^2": 1489.2 + } +} \ No newline at end of file diff --git a/398/InvasionFront_CD8_block10_x3_y7_patient398_0.json b/398/InvasionFront_CD8_block10_x3_y7_patient398_0.json new file mode 100644 index 0000000000000000000000000000000000000000..260b3a6932428c56d47a4a1a05b3f51c7d29858a --- /dev/null +++ b/398/InvasionFront_CD8_block10_x3_y7_patient398_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12543.4, + "Centroid Y µm": 23837.4, + "Num Detections": 19366, + "Num Negative": 16506, + "Num Positive": 2860, + "Positive %": 14.77, + "Num Positive per mm^2": 1263.0 + } +} \ No newline at end of file diff --git a/398/InvasionFront_CD8_block10_x4_y7_patient398_1.json b/398/InvasionFront_CD8_block10_x4_y7_patient398_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f2c788b2c7ea31e82f7a2b6fc3b0407d6aa11a76 --- /dev/null +++ b/398/InvasionFront_CD8_block10_x4_y7_patient398_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15042.0, + "Centroid Y µm": 23237.7, + "Num Detections": 19649, + "Num Negative": 16428, + "Num Positive": 3221, + "Positive %": 16.39, + "Num Positive per mm^2": 1495.8 + } +} \ No newline at end of file diff --git a/398/TumorCenter_CD3_block10_x3_y7_patient398_0.json b/398/TumorCenter_CD3_block10_x3_y7_patient398_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ad21fe980913668061c045cbea0290640659d16c --- /dev/null +++ b/398/TumorCenter_CD3_block10_x3_y7_patient398_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 17365.8, + "Num Detections": 24234, + "Num Negative": 22379, + "Num Positive": 1855, + "Positive %": 7.655, + "Num Positive per mm^2": 742.6 + } +} \ No newline at end of file diff --git a/398/TumorCenter_CD3_block10_x4_y7_patient398_1.json b/398/TumorCenter_CD3_block10_x4_y7_patient398_1.json new file mode 100644 index 0000000000000000000000000000000000000000..11c206c3ac433d4138b45eaa2298f401679880f6 --- /dev/null +++ b/398/TumorCenter_CD3_block10_x4_y7_patient398_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 17240.9, + "Num Detections": 18903, + "Num Negative": 16086, + "Num Positive": 2817, + "Positive %": 14.9, + "Num Positive per mm^2": 1152.6 + } +} \ No newline at end of file diff --git a/398/TumorCenter_CD8_block10_x3_y7_patient398_0.json b/398/TumorCenter_CD8_block10_x3_y7_patient398_0.json new file mode 100644 index 0000000000000000000000000000000000000000..faada146ec9a7f35b64655f89cb6887b5fc27ccf --- /dev/null +++ b/398/TumorCenter_CD8_block10_x3_y7_patient398_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11269.0, + "Centroid Y µm": 18015.5, + "Num Detections": 22710, + "Num Negative": 18221, + "Num Positive": 4489, + "Positive %": 19.77, + "Num Positive per mm^2": 1638.9 + } +} \ No newline at end of file diff --git a/398/TumorCenter_CD8_block10_x4_y7_patient398_1.json b/398/TumorCenter_CD8_block10_x4_y7_patient398_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d3c3707018db67c9fcd1884fddb795267f0a3edc --- /dev/null +++ b/398/TumorCenter_CD8_block10_x4_y7_patient398_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13842.7, + "Centroid Y µm": 17890.5, + "Num Detections": 20952, + "Num Negative": 16200, + "Num Positive": 4752, + "Positive %": 22.68, + "Num Positive per mm^2": 1887.4 + } +} \ No newline at end of file diff --git a/398/history_text.txt b/398/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3bb9a4132cfef4cf27480c228786a92c3ba30b8b --- /dev/null +++ b/398/history_text.txt @@ -0,0 +1 @@ +A cT2cN2bg2 oropharyngeal carcinoma was histologically confirmed in the patient during a panendoscopy <2013>. In our interdisciplinary tumor conference, the indication for primary surgery was given. \ No newline at end of file diff --git a/398/icd_codes.txt b/398/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/398/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/398/ops_codes.txt b/398/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d1f1ae5d68847199df7ea66f1df9968c9fe955b6 --- /dev/null +++ b/398/ops_codes.txt @@ -0,0 +1 @@ +Partielle Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.14 ] Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Sonstige diagnostische Pharyngoskopie[1-611.x ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Kontinuierliche Sogbehandlung mit Pumpensystem bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.20 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] \ No newline at end of file diff --git a/398/patient_clinical_data.json b/398/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..87257761f1d0b34fe0c6493a6c32d8508ae1d5fd --- /dev/null +++ b/398/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 10, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/398/patient_pathological_data.json b/398/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..50c6a457cca4c72f1c2af558079047928a9f1b77 --- /dev/null +++ b/398/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "398", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/398/surgery_description.txt b/398/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..15d6278f4ea6795a5b62975bf4987eb1462b4a03 --- /dev/null +++ b/398/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Defect reconstruction, Free flap (Radial), Neck dissection, Plastic tracheotomy, PEG placement diff --git a/398/surgery_report.txt b/398/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..33c6e563856ae61cca527cf677c37a4c511fd774 --- /dev/null +++ b/398/surgery_report.txt @@ -0,0 +1 @@ +After an introductory consultation with the anesthesia colleagues, preparation by the anesthesia colleagues and positioning of the patient. The primary tumor is inspected first. This is done with the small bore tube under dental protection. There is a rough mass in the right tonsil lobe extending submucosally into the soft palate. On palpation, it clearly extends laterally towards the soft tissue of the neck and clearly exceeds the caudal border of the tonsillar lobe. Growth into the glosso tonsillar groove, but no tongue infiltration. The tumor extends submucosally to the mandible, but clearly does not infiltrate it. The PEG is now inserted. This is done with the gastroscope under laryngoscopic control. Easy advancement into the stomach. Excellent diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. Inconspicuous oesophagus on reflection. After positioning the patient, injection of xylocaine with adrenaline additive cervically due to lateral growth, primarily transcervical procedure to secure the cervical vascular sheath. For this purpose, a skin incision is made at the anterior edge of the sternocleidomastoid muscle, the skin and subcutaneous tissue are cut, the platysma is cut, the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle are exposed. First expose and clear the anterior neck preparation and preserve the superior thyroid artery, the hyperglossal nerve and the cervical vein. A true facial vein is not pronounced, preservation of the extremely strong external jugular vein. Now free preparation of the internal jugular vein. Macroscopically, there are clearly conspicuous nodules in levels II and III due to their size. Anterior neurolysis of the hypergossic nerve with attached cervical vein. Reintegration of the nerve, followed by exposure of the accessorius nerve, also here neurolysis and reinsertion of the nerve. After complete exposure of the cervical vascular sheath, the vagus nerve is also exposed. This is also mobilized by neurolysis and then re-embedded. Elongated exposure of the common carotid artery, the bulb and the internal and external carotid artery. The facial vein is alloyed during subsequent dissection of the transcervical access artery, but is otherwise preserved. All carotid branches. The accessorius triangle is then dissected and level V dissected, carefully preserving the cervical plexus branches. The submandibular gladula is now released with careful protection and release of the marginal mandibular ramus, re-embedding of the nerve, separation of the gland, resection of the digastric muscle, posterior venter, removal of level I b. Here too, several nodules measuring up to 1.5 cm. The tumor can now be clearly palpated in the area of the lateral pharyngeal wall. Now combined transoral and transcervical procedure. Cut around the tumor with a visual distance of a good 1 cm. Reaching from paraovular over the soft palate up to the algular ridge and just including the lateral edge of the tongue, also resection up to the posterior floor of the mouth. It can be seen that the tumor also clearly infiltrates the posterior palatal arch including the musculature. Therefore complete involvement of the muscular posterior palatal arch. Resection down to the posterior pharyngeal wall. Macroscopic in sano resection on all sides both to the edges and clearly basally. Transcervical completion of the tumor dissection also towards the caudal pharyngeal wall. Macroscopic in sano. The tumor specimen is now sent in thread-marked for frozen section diagnostics. This shows discontinuous tumor growth in the area of the lateral margin. Therefore, according to the buccal mucosa of the alveolar ridge and the posterior floor of the mouth, resection specimens are taken and imaged with new margin samples. These are finally diagnosed as tumor-free in the frozen section diagnostics. Otherwise, all resection margins are tumor-free without high-grade dysplasia. The defect is now measured for subsequent reconstruction. First the neck dissection of the opposite side. To do this, make a skin incision on the anterior edge of the sternocleidomastoid muscle, cut through the skin and subcutaneous tissue, cut through the platysma, expose the sternocleidomastoid muscle and the omohyoid muscle, Release of the submandibular gland, exposure of the digastric muscle, removal of the anterior neck preparation while preserving the superior thyroid artery and then neurolysis of the hyperglossal nerve with attached cervical nerve. Re-embedding of the nerve. Dissection of the internal jugular vein, exposure of the accessorius nerve, neurolysis of the nerve and re-embedding. Clearing of the accessorius triangle with careful protection of the nerve. Subsequent evacuation of level V a with careful protection of the cervical plexus branches. There may be a caudal indication of lymph leakage. Overall, no suspicious lymph node changes on the left side. Final wound irrigation with Ringer's solution, insertion of a 10-gauge redon drain if the wound is absolutely dry and careful two-layer wound closure. The plastic tracheostomy is then performed. Skin incision below the cricoid cartilage. Cut through the skin and subcutaneous tissue, expose and cut through the infrahyoid musculature. Exposure of the cricoid cartilage and the anterior surface of the trachea. Exposure of the thyroid isthmus. Dissection of the thyroid isthmus after supply. Insertion between the second and third tracheal ring. Creation of a wide-base styled PJ flap and subsequent insertion of the tracheostoma with mucocutaneous anastomosis. Subsequently, problem-free reintubation to a size 8 low-coff cannula. The radialis graft is then lifted from the left forearm. After marking, the 9x6 cm graft is measured with a special soft palate and mouth configuration. Cutting around the graft, exposing and taking along the cephalic vein. Exposure of the superficial ramus, radial nerve and complete preservation of the nerve. Exposure of the brachioradialis muscle. Exposure of the distal vascular pedicle, transection of the vascular pedicle. Reciprocal exposure of the flexor carpi ulnaris muscle, strictly subfacial release of the graft. Subsequent preparation of the pedicle, including the cephalic vein. Cubital part showing a strong vascular connection from superficial to deep venous systems. Therefore preservation of the venous bridge. Exposure and preservation of the common interosseous artery. Removal of the radial artery. After reopening the tourniquet with a vital graft and regular blood supply to the hand. Careful hemostasis. Subsequent careful two-layer wound closure. Incision of the full-thickness skin graft harvested from the right groin. Application of a vacuum dressing and positioning of the ......... in a functional position. Subsequent repositioning of the arm. For full-thickness skin harvesting from the right groin. Incision of an oval skin area measuring approx. 10x6 cm. Strictly cutaneous elevation. Careful subcutaneous mobilization, insertion of a 10-redon drain in dry wound conditions and multi-layer wound closure. Now combined transoral and transcervical graft fitting. Overall very good fit and sufficient and complete reconstruction of the defect. Conditioning of the superior thyroid artery and the strong superior thyroid vein. For anastomization, perform the arterial anastomosis with 8.0 Ethilon. This is successful with immediate venous return. Conditioning of the vein. Measure a size 4.0 cuppler and perform the venous anastomosis with the cuppler system. Subsequent regular graft perfusion as well as positive spreading phenomenon and regular style pulsation, so that after careful wound irrigation and inspection, insertion of a 10-gauge Redon drainage and careful wound closure. The patient was then repositioned, a final consultation was held with the anesthesia colleagues and the procedure was completed with a vital graft. The patient received intraoperative intravenous antibiotics with 3g Unacid. Please continue this for 24 hours postoperatively. Conclusion: Intraoperative R0-resistant at least cT2 and cN2B oropharyngeal carcinoma on the right. Careful postoperative flap monitoring. If the graft heals properly and the graft is intact, a gradual diet can be started from the eighth postoperative day with a good prognosis with regard to swallowing function. Presentation at our interdisciplinary tumor conference to plan adjuvant therapy. \ No newline at end of file diff --git a/399/InvasionFront_CD3_block2_x5_y2_patient399_0.json b/399/InvasionFront_CD3_block2_x5_y2_patient399_0.json new file mode 100644 index 0000000000000000000000000000000000000000..262f3b78f0547e85424cdae3fa4fa58e5e10e4a3 --- /dev/null +++ b/399/InvasionFront_CD3_block2_x5_y2_patient399_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18840.0, + "Centroid Y µm": 18515.2, + "Num Detections": 32496, + "Num Negative": 32442, + "Num Positive": 54, + "Positive %": 0.1662, + "Num Positive per mm^2": 18.59 + } +} \ No newline at end of file diff --git a/399/InvasionFront_CD3_block2_x6_y2_patient399_1.json b/399/InvasionFront_CD3_block2_x6_y2_patient399_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bcb935ac5b3401d784f4728fb238346f7c098a19 --- /dev/null +++ b/399/InvasionFront_CD3_block2_x6_y2_patient399_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21463.6, + "Centroid Y µm": 18565.2, + "Num Detections": 30730, + "Num Negative": 30719, + "Num Positive": 11, + "Positive %": 0.0358, + "Num Positive per mm^2": 3.922 + } +} \ No newline at end of file diff --git a/399/InvasionFront_CD8_block2_x5_y2_patient399_0.json b/399/InvasionFront_CD8_block2_x5_y2_patient399_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d8f1a583734abb4c6174dd84eb631bde97d8633b --- /dev/null +++ b/399/InvasionFront_CD8_block2_x5_y2_patient399_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17615.7, + "Centroid Y µm": 6046.8, + "Num Detections": 31699, + "Num Negative": 31679, + "Num Positive": 20, + "Positive %": 0.0631, + "Num Positive per mm^2": 6.862 + } +} \ No newline at end of file diff --git a/399/InvasionFront_CD8_block2_x6_y2_patient399_1.json b/399/InvasionFront_CD8_block2_x6_y2_patient399_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3868d922b21f56e03950eddbac3098ac54fee8fe --- /dev/null +++ b/399/InvasionFront_CD8_block2_x6_y2_patient399_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20289.3, + "Centroid Y µm": 6071.8, + "Num Detections": 30559, + "Num Negative": 30537, + "Num Positive": 22, + "Positive %": 0.072, + "Num Positive per mm^2": 7.831 + } +} \ No newline at end of file diff --git a/399/TumorCenter_CD3_block2_x5_y2_patient399_0.json b/399/TumorCenter_CD3_block2_x5_y2_patient399_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e98fe943f4d2b97270288a3a02d45dc588b17704 --- /dev/null +++ b/399/TumorCenter_CD3_block2_x5_y2_patient399_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16766.1, + "Centroid Y µm": 4847.4, + "Num Detections": 26891, + "Num Negative": 26878, + "Num Positive": 13, + "Positive %": 0.0483, + "Num Positive per mm^2": 4.894 + } +} \ No newline at end of file diff --git a/399/TumorCenter_CD3_block2_x6_y2_patient399_1.json b/399/TumorCenter_CD3_block2_x6_y2_patient399_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c565adb5205e35c18e8987b182c76ea23bf9fb47 --- /dev/null +++ b/399/TumorCenter_CD3_block2_x6_y2_patient399_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19339.8, + "Centroid Y µm": 4897.4, + "Num Detections": 30541, + "Num Negative": 30522, + "Num Positive": 19, + "Positive %": 0.0622, + "Num Positive per mm^2": 6.866 + } +} \ No newline at end of file diff --git a/399/TumorCenter_CD8_block2_x5_y2_patient399_0.json b/399/TumorCenter_CD8_block2_x5_y2_patient399_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff4610b0a864d2a7dbb5eb5b82d435cbbb2885e1 --- /dev/null +++ b/399/TumorCenter_CD8_block2_x5_y2_patient399_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17890.5, + "Centroid Y µm": 4397.7, + "Num Detections": 28061, + "Num Negative": 28054, + "Num Positive": 7, + "Positive %": 0.0249, + "Num Positive per mm^2": 2.636 + } +} \ No newline at end of file diff --git a/399/TumorCenter_CD8_block2_x6_y2_patient399_1.json b/399/TumorCenter_CD8_block2_x6_y2_patient399_1.json new file mode 100644 index 0000000000000000000000000000000000000000..861fd771c14c2e2fc8c9066669c6ae61b8af313a --- /dev/null +++ b/399/TumorCenter_CD8_block2_x6_y2_patient399_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20439.2, + "Centroid Y µm": 4297.7, + "Num Detections": 32103, + "Num Negative": 32101, + "Num Positive": 2, + "Positive %": 0.0062, + "Num Positive per mm^2": 0.7082 + } +} \ No newline at end of file diff --git a/399/history_text.txt b/399/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..ae7481680da83a29b0bfdb4d5ec874796c033e48 --- /dev/null +++ b/399/history_text.txt @@ -0,0 +1 @@ +Patient in a palliative situation with small cell bronchial carcinoma. There is a large mass in the area of the left pharyngeal wall with transition to the base of the tongue, which impairs both speech and swallowing. The above-mentioned operation was therefore indicated. \ No newline at end of file diff --git a/399/icd_codes.txt b/399/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2405a3a2a1f520660c5cade89c8e5753d0d51ba7 --- /dev/null +++ b/399/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] \ No newline at end of file diff --git a/399/ops_codes.txt b/399/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/399/patient_clinical_data.json b/399/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fb503b67a59064cb19de0a4fb9572c777ae13215 --- /dev/null +++ b/399/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 58, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/399/patient_pathological_data.json b/399/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8290a6bb5cef312a75099c2b1a0442dbc56fe700 --- /dev/null +++ b/399/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "399", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "NX", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/399/surgery_description.txt b/399/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c19570f67abbd42e5830701f13effd92a97c0135 --- /dev/null +++ b/399/surgery_description.txt @@ -0,0 +1 @@ +Pharyngoscopy, Laryngoscopy, Excision of a suspicious malignant mass diff --git a/399/surgery_report.txt b/399/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ee40b3c455d647b198cfa4a6a1070c9dcc84d1d --- /dev/null +++ b/399/surgery_report.txt @@ -0,0 +1 @@ +First positioning of the patient, orotracheal intubation after tracheoscopy, which revealed no special features. Start with pharyngoscopy. There is an exophytic mass in the area of the right tonsillar lobe, which runs across the glossotonsillar junction to the border of the base of the tongue. The rest of the examination shows no special features. Laryngoscopy also shows no special features. The mass is extirpated in toto together with the tonsil, including parts of the anterior palatine arch, leaving the posterior palatine arch intact and including parts of the base of the tongue. Subsequent careful hemostasis. No evidence of bleeding on final inspection, not even on repeated inspection. The procedure is completed without complications. The specimen is sent for final histology. Macroscopic evidence of malignancy, although lymphoma could also be a possibility in addition to small cell bronchial carcinoma. \ No newline at end of file diff --git a/400/InvasionFront_CD3_block2_x3_y11_patient400_0.json b/400/InvasionFront_CD3_block2_x3_y11_patient400_0.json new file mode 100644 index 0000000000000000000000000000000000000000..89997c09752cdca1b58018028b34d4a1c4d87de5 --- /dev/null +++ b/400/InvasionFront_CD3_block2_x3_y11_patient400_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 40978.3, + "Num Detections": 10879, + "Num Negative": 9790, + "Num Positive": 1089, + "Positive %": 10.01, + "Num Positive per mm^2": 676.51 + } +} \ No newline at end of file diff --git a/400/InvasionFront_CD3_block2_x4_y11_patient400_1.json b/400/InvasionFront_CD3_block2_x4_y11_patient400_1.json new file mode 100644 index 0000000000000000000000000000000000000000..16b2d41cada907b2a29feade96e7fb7e8234c669 --- /dev/null +++ b/400/InvasionFront_CD3_block2_x4_y11_patient400_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15941.6, + "Centroid Y µm": 41053.3, + "Num Detections": 20943, + "Num Negative": 18052, + "Num Positive": 2891, + "Positive %": 13.8, + "Num Positive per mm^2": 1402.4 + } +} \ No newline at end of file diff --git a/400/InvasionFront_CD8_block2_x3_y11_patient400_0.json b/400/InvasionFront_CD8_block2_x3_y11_patient400_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ebb43059b8295dfbefc52840eb48280307ca3713 --- /dev/null +++ b/400/InvasionFront_CD8_block2_x3_y11_patient400_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12068.6, + "Centroid Y µm": 28609.9, + "Num Detections": 26028, + "Num Negative": 23400, + "Num Positive": 2628, + "Positive %": 10.1, + "Num Positive per mm^2": 1053.7 + } +} \ No newline at end of file diff --git a/400/InvasionFront_CD8_block2_x4_y11_patient400_1.json b/400/InvasionFront_CD8_block2_x4_y11_patient400_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8251438c545df20229d04696984379d034324e06 --- /dev/null +++ b/400/InvasionFront_CD8_block2_x4_y11_patient400_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14617.3, + "Centroid Y µm": 28809.7, + "Num Detections": 21699, + "Num Negative": 18990, + "Num Positive": 2709, + "Positive %": 12.48, + "Num Positive per mm^2": 1288.8 + } +} \ No newline at end of file diff --git a/400/TumorCenter_CD3_block2_x3_y11_patient400_0.json b/400/TumorCenter_CD3_block2_x3_y11_patient400_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5242b121b330edff0cde02a17e4e0cac562d2408 --- /dev/null +++ b/400/TumorCenter_CD3_block2_x3_y11_patient400_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10694.3, + "Centroid Y µm": 26985.7, + "Num Detections": 17996, + "Num Negative": 15712, + "Num Positive": 2284, + "Positive %": 12.69, + "Num Positive per mm^2": 1320.1 + } +} \ No newline at end of file diff --git a/400/TumorCenter_CD3_block2_x4_y11_patient400_1.json b/400/TumorCenter_CD3_block2_x4_y11_patient400_1.json new file mode 100644 index 0000000000000000000000000000000000000000..094c89865582c495e1e4affb26050c721224e09b --- /dev/null +++ b/400/TumorCenter_CD3_block2_x4_y11_patient400_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 27160.6, + "Num Detections": 15838, + "Num Negative": 13898, + "Num Positive": 1940, + "Positive %": 12.25, + "Num Positive per mm^2": 1263.7 + } +} \ No newline at end of file diff --git a/400/TumorCenter_CD8_block2_x3_y11_patient400_0.json b/400/TumorCenter_CD8_block2_x3_y11_patient400_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b08c4acade797e3f605cd358ca38792a9f3493b8 --- /dev/null +++ b/400/TumorCenter_CD8_block2_x3_y11_patient400_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13068.1, + "Centroid Y µm": 27110.6, + "Num Detections": 8642, + "Num Negative": 7971, + "Num Positive": 671, + "Positive %": 7.764, + "Num Positive per mm^2": 621.76 + } +} \ No newline at end of file diff --git a/400/TumorCenter_CD8_block2_x4_y11_patient400_1.json b/400/TumorCenter_CD8_block2_x4_y11_patient400_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0a8848ad403d452d5904ab9221ce886169c07c27 --- /dev/null +++ b/400/TumorCenter_CD8_block2_x4_y11_patient400_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 27110.6, + "Num Detections": 19802, + "Num Negative": 16995, + "Num Positive": 2807, + "Positive %": 14.18, + "Num Positive per mm^2": 1463.6 + } +} \ No newline at end of file diff --git a/400/history_text.txt b/400/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..f1198aed0434888a5bed3f9ba6ea56baae178e54 --- /dev/null +++ b/400/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed HPV-positive squamous cell carcinoma of the left tonsillar lobe. On CT, extension to the lateral side, not clearly definable. Therefore patient also informed about flap coverage after tumor resection. \ No newline at end of file diff --git a/400/icd_codes.txt b/400/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..adc050c8f628f1e558c676f540ed678cb6876eb8 --- /dev/null +++ b/400/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/400/ops_codes.txt b/400/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d92e2ebbf11f2fae7dc98245545ba97e83ef27bb --- /dev/null +++ b/400/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit lokaler Schleimhaut[5-295.01 ] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] \ No newline at end of file diff --git a/400/patient_clinical_data.json b/400/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..2de39d184a7047189ccfac2ffd5a0926bc0b99b1 --- /dev/null +++ b/400/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 17, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/400/patient_pathological_data.json b/400/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a7dd9533ca36577ff4c89c536d54803e84bb37f7 --- /dev/null +++ b/400/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "400", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 18, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/400/surgery_description.txt b/400/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..3613520d6b790cd53d06d77328b8c33e0ce30e55 --- /dev/null +++ b/400/surgery_description.txt @@ -0,0 +1 @@ +Resection, Bilateral neck dissection, PEG placement, Tracheotomy diff --git a/400/surgery_report.txt b/400/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..2eca44d609a82fe6facfd2f9fdbcd6bf709ea2ca --- /dev/null +++ b/400/surgery_report.txt @@ -0,0 +1 @@ +Initial consultation with the anesthesiologist. After preparation and intubation by the anesthesia colleagues, pharyngoscopy and laryngoscopy again: The tumor is visible, which is located in the area of the left tonsil and slightly exceeds it. However, the tumor is mobile on palpation, so that a transoral resection may be possible without flap coverage. Placement of the PEG: Entering the stomach with the flexible esophagoscope. After diaphanoscopy has been performed, a PEG tube is inserted in a typical manner without complications. Fixation to the abdominal wall in a typical manner. Sterile dressing. Transoral tumor resection: The tumor is macroscopically incised on all sides with an electric needle or scissors at a safety distance of 0.5 - 1 cm. A good layer is found laterally. The posterior palatal arch can be largely preserved, the anterior palatal arch is resected with parts of the adjacent fatty tissue. The resection extends caudally to the level of the epiglottis. The base of the tongue is resected only at the edges with a safety margin. The preparation is marked with a suture. A marginal sample is taken from the area of the mucosa of the posterior palatal arch from the cranial to the caudal end of the tumor. Also a marginal sample from the area from the glossoalveolar junction to the caudal pharynx via the base of the tongue. In the frozen section, tumor removed on all sides in healthy tissue, but with a very narrow safety margin of 0.2 cm in the area of the specimen. Marginal samples, which were taken separately, are free. Despite the fact that the tumor was removed from healthy tissue, further soft tissue was resected cranially and cranial-medially, but this was sent for final histology. Adaptation of the posterior palatal arch with the pharyngeal wall in the most cranial area using two sutures. Overall borderline situation with regard to flap coverage. Overall, however, flap coverage is not absolutely necessary if the posterior palatal arch is preserved. However, extensive resection in the cranial soft tissue area. Transfer to neck dissection on both sides now follows. First disinfect the skin. Injection of a total of 8 ml Ultracaine 1% with adrenaline into the sides of the neck on both sides. Subsequent cranial incision, which ends in a neck fold. Neck dissection on the left: Skin incision as described. Subsequent dissection through the subcutaneous tissue and platysma. A very small external jugular vein is ligated. N. auricularis magnus is preserved. Exposure, displacement and, at the end of the operation, re-embedding of the auricularis magnus nerve in the sense of a neurolysis. Exposure of the sternocleidomastoid muscle, omohyoid muscle, digastric muscle and the infrahyoid muscles. Dissection of the cervical vascular sheath. A lymph node conglomerate is located on this. Clinical evidence of soft tissue infiltration. However, the lymph node conglomerate can be dissected away caudally from the submandibular gland. The same applies to the area of the internal jugular vein, which is not infiltrated. Exposure of the external/internal carotid artery, superior thyroid artery, facial artery and lingual artery. The lingual artery is ligated. Subsequent successive clearing of levels II to V. This largely preserves the branches of the cervical plexus. Exposure, relocation and, at the end of the operation, re-embedding of the vagus nerve, hypoglossal nerve and accessorius nerve in the sense of a neurolysis. Also branches of the cervical plexus, between which the lymph nodes of level V a are removed. Irrigation of the wound area. Careful hemostasis. No evidence of bleeding, chyle flow or other complications. Layered wound closure with insertion of a Redon drain. Application of a pressure dressing. Neck dissection on the right: This is done in the same way as on the left. Level II to V are removed as described on the left side. Enlarged and suspicious lymph nodes are also found here, but not as clearly as on the right side. However, overall there were also suspicious lymph node metastases here. Also presentation, relocation and at the end of the operation re-embedding of the auricularis magnus nerve, vagus nerve, hypoglossal nerve and accessorius nerve in the sense of a neurolysis. Irrigation and hemostasis. Careful revision, no evidence of complications and layered wound closure with insertion of a Redon drain. Application of a pressure dressing. Tracheostoma creation: Small Kocher collar incision. Dissection through the fatty tissue to the infrahyoid musculature. Larger veins are ligated. Exposure of the infrahyoid musculature, which is divided. Subsequent exposure of the thyroid isthmus. This is dissected, which is successful using bipolar coagulation with a thin isthmus. Subsequent exposure of the trachea. Entering the trachea in the 2nd/3rd intercartilaginous space. Creation of a visor flap. This is epithelized using six sutures. Subsequent re-intubation. Insertion of an 8-gauge tracheostomy tube. Lateral skin areas are closed with sutures. Another enoral inspection: Here again careful hemostasis. Two ligatures were placed laterally in the area of the pharyngeal wall as part of the transoral resection. No more bleeding visible here. The procedure was then completed without complications. Final consultation with the anesthesiologist. The patient goes to the intensive care unit for monitoring. Please continue antibiotics as started intraoperatively with Unacid for a total of one week. Total cT2 oropharyngeal carcinoma on the left and lymph node metastases on both sides. Left side probably with soft tissue infiltration or extracapsular infiltration, so radiochemotherapy will most likely be necessary postoperatively. Waiting for the final histology. Planning of the further procedure depending on the final histology. Food should be restored after one week at the earliest, until then nutrition via the inserted PEG. \ No newline at end of file diff --git a/401/InvasionFront_CD3_block19_x3_y1_patient401_0.json b/401/InvasionFront_CD3_block19_x3_y1_patient401_0.json new file mode 100644 index 0000000000000000000000000000000000000000..090f6d4db8d6362281e572b75a115b961fd88893 --- /dev/null +++ b/401/InvasionFront_CD3_block19_x3_y1_patient401_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12868.2, + "Centroid Y µm": 5072.3, + "Num Detections": 21619, + "Num Negative": 20847, + "Num Positive": 772, + "Positive %": 3.571, + "Num Positive per mm^2": 305.98 + } +} \ No newline at end of file diff --git a/401/InvasionFront_CD3_block19_x4_y1_patient401_1.json b/401/InvasionFront_CD3_block19_x4_y1_patient401_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65dfd14c2cfd61a46e2e0c2d27e38917799aeb2f --- /dev/null +++ b/401/InvasionFront_CD3_block19_x4_y1_patient401_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15466.8, + "Centroid Y µm": 5172.3, + "Num Detections": 23326, + "Num Negative": 22856, + "Num Positive": 470, + "Positive %": 2.015, + "Num Positive per mm^2": 180.45 + } +} \ No newline at end of file diff --git a/401/InvasionFront_CD8_block19_x3_y1_patient401_0.json b/401/InvasionFront_CD8_block19_x3_y1_patient401_0.json new file mode 100644 index 0000000000000000000000000000000000000000..78234ac171d3afbd1b0127f94d985ef6d9cfe123 --- /dev/null +++ b/401/InvasionFront_CD8_block19_x3_y1_patient401_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11968.7, + "Centroid Y µm": 12450.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/401/InvasionFront_CD8_block19_x4_y1_patient401_1.json b/401/InvasionFront_CD8_block19_x4_y1_patient401_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6659b5cd45531a7f29172c414829a6b2c2964314 --- /dev/null +++ b/401/InvasionFront_CD8_block19_x4_y1_patient401_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14492.3, + "Centroid Y µm": 12525.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/401/TumorCenter_CD3_block19_x3_y1_patient401_0.json b/401/TumorCenter_CD3_block19_x3_y1_patient401_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cfbd5f436982ba3b29b77c4fdaa04889b5252d2e --- /dev/null +++ b/401/TumorCenter_CD3_block19_x3_y1_patient401_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9874.9, + "Centroid Y µm": 3786.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/401/TumorCenter_CD3_block19_x4_y1_patient401_1.json b/401/TumorCenter_CD3_block19_x4_y1_patient401_1.json new file mode 100644 index 0000000000000000000000000000000000000000..89974c72038bee8cc5eb990f186d780decaf6a6d --- /dev/null +++ b/401/TumorCenter_CD3_block19_x4_y1_patient401_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12459.8, + "Centroid Y µm": 3330.5, + "Num Detections": 6293, + "Num Negative": 6257, + "Num Positive": 36, + "Positive %": 0.5721, + "Num Positive per mm^2": 43.3 + } +} \ No newline at end of file diff --git a/401/TumorCenter_CD8_block19_x3_y1_patient401_0.json b/401/TumorCenter_CD8_block19_x3_y1_patient401_0.json new file mode 100644 index 0000000000000000000000000000000000000000..72856b62eca4765e357e60ff3a84e3399e9dc05c --- /dev/null +++ b/401/TumorCenter_CD8_block19_x3_y1_patient401_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13480.7, + "Centroid Y µm": 13307.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/401/TumorCenter_CD8_block19_x4_y1_patient401_1.json b/401/TumorCenter_CD8_block19_x4_y1_patient401_1.json new file mode 100644 index 0000000000000000000000000000000000000000..27b6ef2c462ea2c302a6babd62d26e2639ca712c --- /dev/null +++ b/401/TumorCenter_CD8_block19_x4_y1_patient401_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16031.7, + "Centroid Y µm": 13195.1, + "Num Detections": 4387, + "Num Negative": 4302, + "Num Positive": 85, + "Positive %": 1.938, + "Num Positive per mm^2": 163.56 + } +} \ No newline at end of file diff --git a/401/history_text.txt b/401/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5c990aeb80da5f4b5697ae93ef93bd42a64726e7 --- /dev/null +++ b/401/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed cT4a cN0 M0 G2 glottic laryngeal carcinoma on the left side with a breakthrough in the area of the thyroid cartilage and a multiple sclerosis sign in the area of the left arytenoid cartilage and indication for the above-mentioned measures. \ No newline at end of file diff --git a/401/icd_codes.txt b/401/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3748a4e41c8ea9520f24fd52d1201777b7a3a441 --- /dev/null +++ b/401/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/401/ops_codes.txt b/401/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fa1c893ede05f6696bfeda6d549ff2b804bdf12 --- /dev/null +++ b/401/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] \ No newline at end of file diff --git a/401/patient_clinical_data.json b/401/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..40d32f9286c9abd7067dbe3b96dc4887e0594d4e --- /dev/null +++ b/401/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 79, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/401/patient_pathological_data.json b/401/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..93ce599137f63a3660b6f0d73fa23d70aff7b431 --- /dev/null +++ b/401/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "401", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/401/surgery_description.txt b/401/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ec2fd30640e56e13a0c71059a0023846df5c8192 --- /dev/null +++ b/401/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Myotomy, Provox prosthesis diff --git a/401/surgery_report.txt b/401/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1043d3fb2e0dba8d72f02b3103facc12a97de25f --- /dev/null +++ b/401/surgery_report.txt @@ -0,0 +1 @@ +Anesthesia induction by the anesthesia colleagues and positioning of the patient by the surgeon. A tracheoscopy is performed using O° optics, with normal conditions in the trachea to carina area. The surgeon then performs endotracheal intubation and positions the patient. Laryngoscopy was performed using a Kleinsasser C-tube. This revealed a tumorous mass infiltrating the left hemilarynx from the left arytenoid cartilage to the anterior commissure and clearly growing in the paraglottic space. This makes it a better contraindication to complete laryngectomy and neck dissection on both sides. Application of local anesthesia cervically on both sides and medially. Skin ablation and sterile draping. Creation of a subplatysmal apron flap in the typical manner. Exposure of the cricoid cartilage and the thyroid cartilage isthmus. Undermining of the same. Exposure of the anterior tracheal wall and incision between the 3rd and 4th tracheal cartilage clasp. Fixation of the caudal tracheal margin to the skin edge. Retubation onto a size 8 laryngectomy tube, followed by dissection along the anterior border of the sternocleidomastoid muscle on the right side. Exposure of the capsule of the submandibular gland. Exposure of the accessorius nerve and the digaster muscle (posterior vein). Exposure of the omohyoid muscle and exposure of the cervical vascular sheath from caudal to cranial. Successive dissection along the cervical vascular sheath while sparing it and the plexus branches. Removal of the posterior and anterior neck specimen while protecting the above-mentioned structures. Hemostasis there using bipolar coagulation. The patient is then repositioned and a neck dissection is performed on the left side. Dissection along the anterior border of the sternocleidomastoid muscle on the left side. Exposure of the accessorius nerve in depth. Exposure of the posterior venter of the digaster muscle. Exposure of the omohyoid muscle. Exposure of the cervical vascular sheath. Dissection along the internal jugular vein from caudal to cranial. Successive removal of the posterior and anterior neck preparation while protecting the above-mentioned structures and the plexus branches. Hemostasis there using bipolar coagulation. A total laryngectomy is then performed. Dissection of the prelaryngeal muscles in the midline. Transverse incision of the prelaryngeal musculature at the level of the hyoid bone using a monopolar knife. Median pharyngotomy. Exposure of the epiglottis after transection of the hyoepiglottic ligament. Exposure of the free edge of the epiglottis. The pharyngeal lumen is then opened and the epiglottis is pulled downwards with the hyoid bone. Then scalpel incision along the posterior edge of the thyroid cartilage on both sides, subperichondral preparation and protection of the piriform sinus on both sides. Subsequent mucosal incision along the free epiglottis edges and the aryepiglottic folds on both sides. Joining of both vertical mucosal incisions in the postcricoid area. Submucosal dissection with protection of the mucosa and the submucosa of the anterior esophageal wall between the trachea and esophagus. Dissection to this level caudally and placement of the laryngectomy specimen between the 2nd and 3rd tracheal cartilage clasp. Two margin samples (anterior tracheal resection margin, posterior tracheal resection margin) were taken, which were sent for frozen section and both were found to be tumor-free by the pathology colleague. Subsequently, paramedian myotomy of the cricopharyngeal muscle on the left side and partial resection of the caudal part of the sternocleidomastoid muscle on both sides. Subsequent retrograde placement of a size 10 Provox Vega without any problems. Four-layer pharyngeal suture (mucosan, submucosa, pharyngeal muscle layer, infrahyoid muscles), resulting in complete pharyngeal closure. To secure the pharyngeal suture, several cut pieces of Tachosil were inserted along the entire T-shaped pharyngeal suture. Hemostasis using bipolar coagulation. Dry conditions. Knock back the subplatysmal apron flap and fix its caudal edge to the tracheostoma. Platysma suture, single button skin suture. Application of a pressure bandage, completion of the procedure without complications. Please feed the patient via the inserted nasogastric tube for the next 10 days, then perform an X-ray pre-swallow. The patient received Unacid 3 g intravenously as a single shot intraoperatively. \ No newline at end of file diff --git a/402/InvasionFront_CD3_block16_x5_y4_patient402_0.json b/402/InvasionFront_CD3_block16_x5_y4_patient402_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a874e81605b72e89d6bb43d2a3e800ed58d58720 --- /dev/null +++ b/402/InvasionFront_CD3_block16_x5_y4_patient402_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16956.0, + "Centroid Y µm": 14583.7, + "Num Detections": 21573, + "Num Negative": 19239, + "Num Positive": 2334, + "Positive %": 10.82, + "Num Positive per mm^2": 931.26 + } +} \ No newline at end of file diff --git a/402/InvasionFront_CD3_block16_x6_y4_patient402_1.json b/402/InvasionFront_CD3_block16_x6_y4_patient402_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f4b299e9bc6a418388c6bd9588e65f3e8afdd871 --- /dev/null +++ b/402/InvasionFront_CD3_block16_x6_y4_patient402_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19397.1, + "Centroid Y µm": 14554.8, + "Num Detections": 17488, + "Num Negative": 16389, + "Num Positive": 1099, + "Positive %": 6.284, + "Num Positive per mm^2": 454.85 + } +} \ No newline at end of file diff --git a/402/InvasionFront_CD8_block16_x5_y4_patient402_0.json b/402/InvasionFront_CD8_block16_x5_y4_patient402_0.json new file mode 100644 index 0000000000000000000000000000000000000000..560b1b8776b3d2700db068c61fe34a791f8efe99 --- /dev/null +++ b/402/InvasionFront_CD8_block16_x5_y4_patient402_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16233.3, + "Centroid Y µm": 10117.1, + "Num Detections": 21826, + "Num Negative": 19664, + "Num Positive": 2162, + "Positive %": 9.906, + "Num Positive per mm^2": 867.59 + } +} \ No newline at end of file diff --git a/402/InvasionFront_CD8_block16_x6_y4_patient402_1.json b/402/InvasionFront_CD8_block16_x6_y4_patient402_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fc16f94e1c1e63a6ea6ef44d1879a0f620e3ce9c --- /dev/null +++ b/402/InvasionFront_CD8_block16_x6_y4_patient402_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18727.8, + "Centroid Y µm": 10182.5, + "Num Detections": 19838, + "Num Negative": 18749, + "Num Positive": 1089, + "Positive %": 5.489, + "Num Positive per mm^2": 461.09 + } +} \ No newline at end of file diff --git a/402/TumorCenter_CD3_block16_x5_y4_patient402_0.json b/402/TumorCenter_CD3_block16_x5_y4_patient402_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e23b16bc4ada3952a89d8e621fb35dd4a1e401d0 --- /dev/null +++ b/402/TumorCenter_CD3_block16_x5_y4_patient402_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17165.9, + "Centroid Y µm": 10594.4, + "Num Detections": 13991, + "Num Negative": 12392, + "Num Positive": 1599, + "Positive %": 11.43, + "Num Positive per mm^2": 871.11 + } +} \ No newline at end of file diff --git a/402/TumorCenter_CD3_block16_x6_y4_patient402_1.json b/402/TumorCenter_CD3_block16_x6_y4_patient402_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c86bd52b6ffa7c1a24e1b8b47452593f73864c28 --- /dev/null +++ b/402/TumorCenter_CD3_block16_x6_y4_patient402_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19739.5, + "Centroid Y µm": 10694.3, + "Num Detections": 17840, + "Num Negative": 14091, + "Num Positive": 3749, + "Positive %": 21.01, + "Num Positive per mm^2": 1586.1 + } +} \ No newline at end of file diff --git a/402/TumorCenter_CD8_block16_x5_y4_patient402_0.json b/402/TumorCenter_CD8_block16_x5_y4_patient402_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fa98f315924072afcc55482b837d1c06e62648c4 --- /dev/null +++ b/402/TumorCenter_CD8_block16_x5_y4_patient402_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 10294.5, + "Num Detections": 18478, + "Num Negative": 17583, + "Num Positive": 895, + "Positive %": 4.844, + "Num Positive per mm^2": 389.29 + } +} \ No newline at end of file diff --git a/402/TumorCenter_CD8_block16_x6_y4_patient402_1.json b/402/TumorCenter_CD8_block16_x6_y4_patient402_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d7a2d0940b7f2305f0a9629d5935fbba009affa5 --- /dev/null +++ b/402/TumorCenter_CD8_block16_x6_y4_patient402_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18690.1, + "Centroid Y µm": 10294.5, + "Num Detections": 22157, + "Num Negative": 19415, + "Num Positive": 2742, + "Positive %": 12.38, + "Num Positive per mm^2": 1095.1 + } +} \ No newline at end of file diff --git a/402/history_text.txt b/402/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c9233ce1771142309eb74b46af74480da6203142 --- /dev/null +++ b/402/history_text.txt @@ -0,0 +1 @@ +The patient has a history of histologically confirmed cT2 cN0 G3 squamous cell carcinoma of the tip of the tongue with spread to the paramedian left and a cystic mass medial to the right thyroid cartilage leaf that was detected in the preoperative sonographic examination. Thus indication for the above measures. \ No newline at end of file diff --git a/402/icd_codes.txt b/402/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9b421f5a56a4f075455a07b5756652d22edcb576 --- /dev/null +++ b/402/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Zungenspitze[C02.1 ] Supraglottische unsichere Neubildung[D38.0 ] \ No newline at end of file diff --git a/402/ops_codes.txt b/402/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..7c78c3b97563b1b77e0da52cfe4e40d5e35ee3fb --- /dev/null +++ b/402/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Partielle Glossektomie transoral sonstige[5-251.0x ] Perkutan-endoskopische Gastrostomie[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] \ No newline at end of file diff --git a/402/patient_clinical_data.json b/402/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..21f3352d46d84df88724697e01359c3f38b10a27 --- /dev/null +++ b/402/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 54, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 32, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/402/patient_pathological_data.json b/402/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..16c10f6cfa47a79dccced06436662b20cc7bf358 --- /dev/null +++ b/402/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "402", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 47, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/402/surgery_description.txt b/402/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6efc9b0aca80ca65d88d922c0f66c3f00a11c925 --- /dev/null +++ b/402/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, and Panendoscopy diff --git a/402/surgery_report.txt b/402/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5d53debc898d1f2346ad53ddaaa3a4631c18371b --- /dev/null +++ b/402/surgery_report.txt @@ -0,0 +1 @@ +Initially induction of anesthesia and performance of a rigid tracheoscopy using 0° optics. Inconspicuous conditions in the trachea up to the carina. Then transnasal endotracheal intubation and positioning of the patient by the surgeon. Entry into the endolarynx using a Kleinsasser C-tube. The subglottis was unremarkable, as was the glottis. A small, cystic mass was noticed in the area of the right morgue sinus, which was easily slit using a microscissors. There was a small amount of serous secretion. Repeated inspection. Removal of a part of the cyst wall in the sense of marsupialization and sending the specimen for final histology. Hemostasis with suprarenin-soaked swabs. Pharyngoscopy is then performed using a Kleinsasser C-tube. The piriform sinuses on both sides, the posterior wall of the hypopharynx and the postcricoid region were unremarkable. The posterior and lateral walls of the oropharynx were also unremarkable. A flexible esophagogastroscopy was performed using an endoscope, which was carefully advanced to the stomach under constant insufflation. The entire stomach up to the pylorus was unremarkable. The entire oesophagus was unremarkable. In the same session, a percutaneous endoscopically controlled gastrostomy was performed in the typical manner using the thread pull-through method. This was very successful. Subsequent adjustment of the tumor findings in the oral cavity using 2 self-retaining retractors. Placement of a rein suture and marking of the incision under the tumor findings using an electric needle. Successive removal of the mass at the tip of the tongue. Hemostasis using bipolar coagulation. The specimen is sent in for final histology with thread marking. Collection of 5 marginal samples (cranial towards the back of the tongue, right lateral, left lateral, caudal towards the floor of the mouth, wound bed). The marginal samples are sent for intraoperative frozen section examination and found to be tumor-free by the pathology colleagues. Thus, an R0 situation in the area of the tip of the tongue can be assumed. Repeated inspection. Hemostasis using bipolar coagulation. Removal of the self-retaining retractors. Then perform a neck dissection on both sides of region I, II, III, initially on the right side. Skin spray disinfection, infiltration anesthesia using 6 ml xylocaine solution with added adrenaline 1:200,000 on the right and 5 ml of the same solution on the left. Mark the incision in a skin fold 2 transverse fingers below the mandible. Cut through the skin and subcutaneous tissue. Expose the platysma. Dissection of the platysma and formation of a cranial and caudal platysma flap, exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the nervus accessorius, the digaster muscle and the omohyoid muscle. Exposure of the submandibular gland. Exposure of the internal jugular vein and the cervical vascular sheath successively. Successive removal of the posterior neck preparation on the right while sparing the branches of the cervical plexus and the accessorius nerve. Hemostasis by means of bipolar coagulation. Successive development and removal of the anterior neck preparation. Successive evacuation of region I b around the submandibular gland. Evacuation of region I a. Hemostasis using bipolar coagulation. Now reposition the patient to perform a neck dissection on the left side, region I, II, III. Creation of an incision in a skin fold parallel to the mandibular branch 2 transverse fingers caudal to it. Cut through the skin, the subcutaneous tissue and the platysma. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the nervus accessorius, the digaster muscle and the omohyoid muscle. Exposure of the internal jugular vein and successively of the entire cervical vascular sheath. Exposure and sparing of the cervical vein, as on the opposite side. Successive removal of the posterior neck preparation while sparing the plexus branches and the accessorius nerve. Successive development and removal of the anterior neck preparation. Dissection around the submandibular gland. Successive evacuation of region I b and tracing of the anterior belly of the digaster muscle of region I a. Hemostasis using bipolar coagulation. Demonstration of findings on . Placement of a 10 Redon drain on both sides and two-layer wound closure on both sides. Completion of the procedure without complications. Conclusion: This is a pharyngo/laryngo/tracheoscopy with marsupialization of a cyst in DD laryngocele in the area of the right morgue sinus, placement of a percutaneous endoscopically controlled gastrostomy, transoral, frozen section controlled tumor resection of a tongue tip carcinoma (R0 situation in frozen section) and neck dissection region I, II, III on both sides. \ No newline at end of file diff --git a/403/InvasionFront_CD3_block1_x1_y9_patient403_0.json b/403/InvasionFront_CD3_block1_x1_y9_patient403_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cc49d6e589406f8a44378e98b0b71daacad423e7 --- /dev/null +++ b/403/InvasionFront_CD3_block1_x1_y9_patient403_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3723.0, + "Centroid Y µm": 24037.3, + "Num Detections": 25365, + "Num Negative": 21574, + "Num Positive": 3791, + "Positive %": 14.95, + "Num Positive per mm^2": 1453.8 + } +} \ No newline at end of file diff --git a/403/InvasionFront_CD3_block1_x2_y9_patient403_1.json b/403/InvasionFront_CD3_block1_x2_y9_patient403_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ab3a0482057ce529fc617b3b9f2a99771a2f06ba --- /dev/null +++ b/403/InvasionFront_CD3_block1_x2_y9_patient403_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6194.8, + "Centroid Y µm": 24137.9, + "Num Detections": 17794, + "Num Negative": 17449, + "Num Positive": 345, + "Positive %": 1.939, + "Num Positive per mm^2": 177.01 + } +} \ No newline at end of file diff --git a/403/InvasionFront_CD8_block1_x1_y9_patient403_0.json b/403/InvasionFront_CD8_block1_x1_y9_patient403_0.json new file mode 100644 index 0000000000000000000000000000000000000000..553822bdeac61649af557fdb6149aed70805143d --- /dev/null +++ b/403/InvasionFront_CD8_block1_x1_y9_patient403_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 22413.1, + "Num Detections": 23754, + "Num Negative": 20532, + "Num Positive": 3222, + "Positive %": 13.56, + "Num Positive per mm^2": 1319.8 + } +} \ No newline at end of file diff --git a/403/InvasionFront_CD8_block1_x2_y9_patient403_1.json b/403/InvasionFront_CD8_block1_x2_y9_patient403_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2e94b42ca2158dee077ee23a960aeb82d29df57 --- /dev/null +++ b/403/InvasionFront_CD8_block1_x2_y9_patient403_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 22613.0, + "Num Detections": 16313, + "Num Negative": 16077, + "Num Positive": 236, + "Positive %": 1.447, + "Num Positive per mm^2": 127.94 + } +} \ No newline at end of file diff --git a/403/TumorCenter_CD3_block1_x1_y11_patient403_0.json b/403/TumorCenter_CD3_block1_x1_y11_patient403_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fc04b5e82954298387cd3033bdd7a2a7777b63eb --- /dev/null +++ b/403/TumorCenter_CD3_block1_x1_y11_patient403_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 27560.4, + "Num Detections": 13873, + "Num Negative": 13686, + "Num Positive": 187, + "Positive %": 1.348, + "Num Positive per mm^2": 83.99 + } +} \ No newline at end of file diff --git a/403/TumorCenter_CD3_block1_x2_y11_patient403_1.json b/403/TumorCenter_CD3_block1_x2_y11_patient403_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6aa4545583d64fc451301a915e8755177b047d87 --- /dev/null +++ b/403/TumorCenter_CD3_block1_x2_y11_patient403_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6529.3, + "Centroid Y µm": 27553.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/403/TumorCenter_CD8_block1_x1_y9_patient403_0.json b/403/TumorCenter_CD8_block1_x1_y9_patient403_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f920753329b529c32b3cc89c7288597ffb66a193 --- /dev/null +++ b/403/TumorCenter_CD8_block1_x1_y9_patient403_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6321.7, + "Centroid Y µm": 31283.4, + "Num Detections": 28270, + "Num Negative": 25343, + "Num Positive": 2927, + "Positive %": 10.35, + "Num Positive per mm^2": 1132.4 + } +} \ No newline at end of file diff --git a/403/TumorCenter_CD8_block1_x2_y9_patient403_1.json b/403/TumorCenter_CD8_block1_x2_y9_patient403_1.json new file mode 100644 index 0000000000000000000000000000000000000000..359d61100507466c5544e0cfed274e6c2fd68f36 --- /dev/null +++ b/403/TumorCenter_CD8_block1_x2_y9_patient403_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8970.3, + "Centroid Y µm": 31258.4, + "Num Detections": 25613, + "Num Negative": 22935, + "Num Positive": 2678, + "Positive %": 10.46, + "Num Positive per mm^2": 1042.2 + } +} \ No newline at end of file diff --git a/403/history_text.txt b/403/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/403/icd_codes.txt b/403/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5e81f5a9212b11b948b3b68649c23e15a1cecafb --- /dev/null +++ b/403/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx Seitenwand[C10.2 L] \ No newline at end of file diff --git a/403/ops_codes.txt b/403/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..aafacc1f67eb5c16c04bfc4159f582c03bc76c17 --- /dev/null +++ b/403/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] \ No newline at end of file diff --git a/403/patient_clinical_data.json b/403/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6c067fd490ec3cf367a7b79ced3b3012c5034b10 --- /dev/null +++ b/403/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 43, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/403/patient_pathological_data.json b/403/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..240a0c7dbe9b1601bfe2c6fa5c9f225aca2579c2 --- /dev/null +++ b/403/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "403", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 33, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/403/surgery_description.txt b/403/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..dca41ff532c8a0962d76c2033ca0ba8fd3e839c9 --- /dev/null +++ b/403/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection with partial pharyngotomy, Modified radical bilateral neck dissection diff --git a/403/surgery_report.txt b/403/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fef7f66c0e39320c7b0c0ceea63e32215e7f7fee --- /dev/null +++ b/403/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthetist, then insertion of the mouth guard and inspection of the oropharynx. An approx. 2 cm submucosal nodular change can be seen on the left oropharyngeal side wall paramedian, this is cut around with the scalpel with a safety margin of at least 0.5 cm, then further dissection with pointed scissors and bipolar forceps. Start suture marking still in situ, then successive dissection of the mass macroscopically in healthy tissue. The specimen is thread-marked and sent for frozen section. The pathologist cannot detect any invasive carcinoma or carcinoma in situ. Isolated, moderate dysplasia can be seen in the far lateral area. No resection is performed. During the frozen section break, start with the neck dissection on the right side. Skin incision in the usual manner. Exposure of the sternocleidomastoid muscle, exposure of the omohyoid muscle, exposure of the submandibular gland and the accessorius nerve. Then free preparation of the internal jugular vein, release of the neck preparation II-V while sparing the plexus branches. Level V is also cleared out because slightly enlarged lymph nodes are visible here, which were also removed for this purpose. All structures can be spared except the external jugular vein. Then turn to the opposite side. Here also the usual skin incision along the anterior edge of the sternocleidomastoid, exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the submandibular gland and the cervical vascular sheath with exposure of the internal jugular vein. The external jugular vein was removed. In level II at the border to level Ib there is a large lymph node metastasis which is resected en bloc. The remaining neck level II-V was then released, sparing the plexus branches and all important nerve and vascular structures. Insertion of Redon drains and two-layer wound closure. A gastric tube is not inserted as the defect is only circumscribed. Waiting for the histology and presentation of the patient at the tumor conference to plan adjuvant therapy. Cautious diet build-up with liquid, mushy food possible. \ No newline at end of file diff --git a/404/InvasionFront_CD3_block3_x1_y6_patient404_0.json b/404/InvasionFront_CD3_block3_x1_y6_patient404_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b713670a505b459a2dbdb1cd9eea61feb3baa028 --- /dev/null +++ b/404/InvasionFront_CD3_block3_x1_y6_patient404_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5022.3, + "Centroid Y µm": 19539.7, + "Num Detections": 21975, + "Num Negative": 16856, + "Num Positive": 5119, + "Positive %": 23.29, + "Num Positive per mm^2": 2077.2 + } +} \ No newline at end of file diff --git a/404/InvasionFront_CD3_block3_x2_y6_patient404_1.json b/404/InvasionFront_CD3_block3_x2_y6_patient404_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a27590a84aaa2aca14835c345d2c38d058a1a116 --- /dev/null +++ b/404/InvasionFront_CD3_block3_x2_y6_patient404_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7820.9, + "Centroid Y µm": 20014.4, + "Num Detections": 11956, + "Num Negative": 9766, + "Num Positive": 2190, + "Positive %": 18.32, + "Num Positive per mm^2": 1385.6 + } +} \ No newline at end of file diff --git a/404/InvasionFront_CD8_block3_x1_y6_patient404_0.json b/404/InvasionFront_CD8_block3_x1_y6_patient404_0.json new file mode 100644 index 0000000000000000000000000000000000000000..931a64991a141a0d5ad0872a41bd360e730e4274 --- /dev/null +++ b/404/InvasionFront_CD8_block3_x1_y6_patient404_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5089.5, + "Centroid Y µm": 14824.5, + "Num Detections": 19925, + "Num Negative": 14226, + "Num Positive": 5699, + "Positive %": 28.6, + "Num Positive per mm^2": 2384.7 + } +} \ No newline at end of file diff --git a/404/InvasionFront_CD8_block3_x2_y6_patient404_1.json b/404/InvasionFront_CD8_block3_x2_y6_patient404_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ae6d1268d34ca3c5179d62cb4b1145498c74698 --- /dev/null +++ b/404/InvasionFront_CD8_block3_x2_y6_patient404_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7719.2, + "Centroid Y µm": 14918.8, + "Num Detections": 13771, + "Num Negative": 11943, + "Num Positive": 1828, + "Positive %": 13.27, + "Num Positive per mm^2": 813.53 + } +} \ No newline at end of file diff --git a/404/TumorCenter_CD3_block3_x1_y6_patient404_0.json b/404/TumorCenter_CD3_block3_x1_y6_patient404_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d23933b7867a1e9f13003e677b90f97b9f17b229 --- /dev/null +++ b/404/TumorCenter_CD3_block3_x1_y6_patient404_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3610.6, + "Centroid Y µm": 21238.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/404/TumorCenter_CD3_block3_x2_y6_patient404_1.json b/404/TumorCenter_CD3_block3_x2_y6_patient404_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9b2058f3b1c37bce414e534cfc58d7d1c5fe21e9 --- /dev/null +++ b/404/TumorCenter_CD3_block3_x2_y6_patient404_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6369.7, + "Centroid Y µm": 21098.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/404/TumorCenter_CD8_block3_x1_y6_patient404_0.json b/404/TumorCenter_CD8_block3_x1_y6_patient404_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b29e69ff08838a40062c12ed7d3c0a51c4dca411 --- /dev/null +++ b/404/TumorCenter_CD8_block3_x1_y6_patient404_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4422.7, + "Centroid Y µm": 15916.6, + "Num Detections": 19003, + "Num Negative": 15787, + "Num Positive": 3216, + "Positive %": 16.92, + "Num Positive per mm^2": 1395.3 + } +} \ No newline at end of file diff --git a/404/TumorCenter_CD8_block3_x2_y6_patient404_1.json b/404/TumorCenter_CD8_block3_x2_y6_patient404_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a8fc13a2a4e44fe39f27506c77b78b3b93284693 --- /dev/null +++ b/404/TumorCenter_CD8_block3_x2_y6_patient404_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6996.3, + "Centroid Y µm": 16091.5, + "Num Detections": 21378, + "Num Negative": 17733, + "Num Positive": 3645, + "Positive %": 17.05, + "Num Positive per mm^2": 1560.2 + } +} \ No newline at end of file diff --git a/404/history_text.txt b/404/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/404/icd_codes.txt b/404/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..34a8c2ce4f3a1e2a61d37c796146464e363ee1e6 --- /dev/null +++ b/404/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Seitenwand des Oropharynx[C10.2 L] \ No newline at end of file diff --git a/404/ops_codes.txt b/404/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..67b4ac8d7a85970c40759ed3b633e63c226a979f --- /dev/null +++ b/404/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Permanente Tracheotomie[5-312.0 ] Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Extraktion mehrwurzeliger Zahn[5-230.1 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Sonstige radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit lokaler Schleimhaut[5-296.x1 ] Entfernung perkutan-endoskopische Gastrostomie [PEG][8-123.1 ] \ No newline at end of file diff --git a/404/patient_clinical_data.json b/404/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9b17911048488c6ac6a11973a632a96c2474965f --- /dev/null +++ b/404/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 54, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/404/patient_pathological_data.json b/404/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..de4c6d04d802b97c295fa9c6026c2648be8e93ba --- /dev/null +++ b/404/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "404", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/404/surgery_description.txt b/404/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e26147d0971b7dd36eeec6a021f0922c6d9358da --- /dev/null +++ b/404/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, and Tracheotomy, PEG placement diff --git a/404/surgery_report.txt b/404/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..494733239eef3157359b5652151a2d4104a220b6 --- /dev/null +++ b/404/surgery_report.txt @@ -0,0 +1 @@ +Inspection of the oropharynx on the left side. An exophytic mass is seen here, which extends at the level of the ascending mandible towards the last molar of the maxilla. The tumor extends caudally into the tonsillar lobe and reaches the tip of the hypopharyngeal side wall. Preliminary consultation with the anesthesiologist. The patient has already been positioned and nasotracheally intubated. Insertion of the mouth blocker. Cutting around the tumor with the electric needle. It can be seen here that the tumor extends to the gingiva of the last molar of the left maxilla. Therefore, tooth extraction in toto with all roots. The alveolus appears tumor-free. A frozen section sample is taken from the alveolar margin, which is found to be tumor-free intraoperatively. Further incision of the tumor caudally with a safety margin of about 4-5 mm. The tumor extends caudally to the lower edge of the tonsil lobe. The resection is performed on the pharyngeal musculature. The anterior palatal arch must also be resected here. The posterior palatal arch is preserved in the cranial part. Lateral exposure of pharyngeal fat, which is coagulated here but appears absolutely tumor-free. Marginal samples are also taken from this area. Border samples are also taken after complete tumor excision in the area of the anterior and posterior margin as well as the cranial and caudal margin. All margin samples are also found to be tumor-free intraoperatively in the frozen section. Subsequent subtle hemostasis. Insertion of a hydrogen-soaked swab. Repositioning of the patient for neck dissection on the left side. Injection of local anesthetic with adrenaline. Skin incision along the anterior edge of the sternocleidomastoid. Dissection in layers in depth after cutting through the platysma. Exposure of the cervical vascular sheath. Clearing of neck dissection levels Ib to V and preservation of all branches of the internal jugular vein and external carotid artery. Also exposing the nerve structures. In this case, long-distance exposure of the vagus nerve in the cervical vascular sheath. Displacement, neurolysis and re-embedding of the vagus nerve. Same procedure for the accessorius nerve and hypoglossal nerve. The cervical profunda can also be preserved. Finally, the entire neck preparation is sent for histopathological examination. In the area of the vein angle, slightly enlarged, macroscopically rather suspicious nodules were found. The final result remains to be determined by histopathology. Dissection in the area of the hypoglossal triangle and in the area of the pharynx was carried out extremely carefully. In the end, it is apparent that there is no penetrating defect to the pharynx. Careful palpation of the pharyngeal side wall, which still appears sufficiently thick, so that the decision is now made not to perform a local reconstruction by means of tissue transfer. The pharyngeal side wall is simply tightened slightly and closed over the exposed fatty tissue as a local mucosoplasty. Insertion of a wound flap. Two-layer wound closure of the neck. Repositioning of the patient for neck dissection on the right side. Here too, skin incision along the sternocleidomastoid after injection of local anesthetic with adrenaline. Layer-by-layer dissection in depth. Exposure and transection of the platysma. Exposure of the cervical vascular sheath. This is also exposed over a long distance. Then dissection of the neck preparation of levels Ib to V. All nervous and vascular structures are also preserved here. As part of the dissection, long-distance exposure, displacement, neurolysis and re-embedding of the vagus nerve at the end of the operation. Same procedure in the area of the accessorius and hypoglossal nerve. Preservation of the cervical profunda here too. Finally, subtle hemostasis and insertion of a Redon drain. Two-layer wound closure. Decision to insert a PEG tube due to the defect and the expected adjuvant therapy. Easy insertion into the esophagus with the flexible instrument. Visual visualization up to the stomach, where a regular fold relief is visible. Locate the diaphanoscopy and the appropriate puncture site. Then insert the PEG tube using the thread pull-through method. Positive tenting phenomenon when puncturing the abdominal wall. Aspiration of the insufflated air and reflection of the esophagus. Dressing application. Transition to tracheotomy. Due to the large wound area, after intraoperative discussion of the findings, decision to tracheotomize the patient, in the sense of a protective tracheostomy. Injection of local anesthetic with adrenaline in the area of the jugulum. Modified Kocher incision and layered preparation in depth. Separation of the infralaryngeal and pretracheal muscles in the midline. Exposure of the very slender thyroid isthmus. This is coagulated and cut in the middle. Exposure of the anterior wall of the trachea. Opening of the trachea between the 2nd and 3rd cartilage clasp. Dissection of a Björk flap. Circular mucocutaneous anastomization of the tracheostoma. Re-intubation to a 7-gauge cannula. Dressing application. Final wound check of the neck on both sides and the enoral wound. Application of a pressure dressing on both sides of the neck. Final consultation with the anesthetist. \ No newline at end of file diff --git a/405/InvasionFront_CD3_block6_x3_y10_patient405_0.json b/405/InvasionFront_CD3_block6_x3_y10_patient405_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e49cd91b42785afc4e74e041c04eef8c1f5fb65c --- /dev/null +++ b/405/InvasionFront_CD3_block6_x3_y10_patient405_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11443.9, + "Centroid Y µm": 25936.3, + "Num Detections": 25444, + "Num Negative": 18843, + "Num Positive": 6601, + "Positive %": 25.94, + "Num Positive per mm^2": 2380.1 + } +} \ No newline at end of file diff --git a/405/InvasionFront_CD3_block6_x4_y10_patient405_1.json b/405/InvasionFront_CD3_block6_x4_y10_patient405_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7a19e968d3349087c09c0fc7cd7359f4dbd1ab14 --- /dev/null +++ b/405/InvasionFront_CD3_block6_x4_y10_patient405_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 26136.2, + "Num Detections": 26756, + "Num Negative": 16805, + "Num Positive": 9951, + "Positive %": 37.19, + "Num Positive per mm^2": 3436.9 + } +} \ No newline at end of file diff --git a/405/InvasionFront_CD8_block6_x3_y8_patient405_0.json b/405/InvasionFront_CD8_block6_x3_y8_patient405_0.json new file mode 100644 index 0000000000000000000000000000000000000000..664ce1679d74ada55f2e930a145ef5415eabb86b --- /dev/null +++ b/405/InvasionFront_CD8_block6_x3_y8_patient405_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11943.7, + "Centroid Y µm": 20139.3, + "Num Detections": 13843, + "Num Negative": 13294, + "Num Positive": 549, + "Positive %": 3.966, + "Num Positive per mm^2": 332.68 + } +} \ No newline at end of file diff --git a/405/InvasionFront_CD8_block6_x4_y8_patient405_1.json b/405/InvasionFront_CD8_block6_x4_y8_patient405_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c3efd2ed739ce924ef781439b5cf2e24112ec3f9 --- /dev/null +++ b/405/InvasionFront_CD8_block6_x4_y8_patient405_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14592.3, + "Centroid Y µm": 20364.2, + "Num Detections": 17487, + "Num Negative": 17373, + "Num Positive": 114, + "Positive %": 0.6519, + "Num Positive per mm^2": 54.13 + } +} \ No newline at end of file diff --git a/405/TumorCenter_CD3_block6_x3_y8_patient405_0.json b/405/TumorCenter_CD3_block6_x3_y8_patient405_0.json new file mode 100644 index 0000000000000000000000000000000000000000..99f84a727f6f1cde317ae3195d98158ca49eb130 --- /dev/null +++ b/405/TumorCenter_CD3_block6_x3_y8_patient405_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 20439.2, + "Num Detections": 14967, + "Num Negative": 14336, + "Num Positive": 631, + "Positive %": 4.216, + "Num Positive per mm^2": 372.46 + } +} \ No newline at end of file diff --git a/405/TumorCenter_CD3_block6_x4_y8_patient405_1.json b/405/TumorCenter_CD3_block6_x4_y8_patient405_1.json new file mode 100644 index 0000000000000000000000000000000000000000..90fcdaedd07739d62ff8b7bcb95bd1e6ec7db4c8 --- /dev/null +++ b/405/TumorCenter_CD3_block6_x4_y8_patient405_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 20339.2, + "Num Detections": 4400, + "Num Negative": 4017, + "Num Positive": 383, + "Positive %": 8.705, + "Num Positive per mm^2": 722.31 + } +} \ No newline at end of file diff --git a/405/TumorCenter_CD8_block6_x3_y8_patient405_0.json b/405/TumorCenter_CD8_block6_x3_y8_patient405_0.json new file mode 100644 index 0000000000000000000000000000000000000000..db8c8ad10f1c0392b1da2e6ba5a1e2164fe76e6e --- /dev/null +++ b/405/TumorCenter_CD8_block6_x3_y8_patient405_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11169.1, + "Centroid Y µm": 20814.0, + "Num Detections": 19572, + "Num Negative": 19330, + "Num Positive": 242, + "Positive %": 1.236, + "Num Positive per mm^2": 115.41 + } +} \ No newline at end of file diff --git a/405/TumorCenter_CD8_block6_x4_y8_patient405_1.json b/405/TumorCenter_CD8_block6_x4_y8_patient405_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ea0345a885f7035a07fac9c633f77c34139cfabb --- /dev/null +++ b/405/TumorCenter_CD8_block6_x4_y8_patient405_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13817.7, + "Centroid Y µm": 20764.0, + "Num Detections": 6769, + "Num Negative": 6471, + "Num Positive": 298, + "Positive %": 4.402, + "Num Positive per mm^2": 372.17 + } +} \ No newline at end of file diff --git a/405/history_text.txt b/405/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/405/icd_codes.txt b/405/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/405/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/405/ops_codes.txt b/405/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..36f394474d8a48791678d60a30b957f9618d2a28 --- /dev/null +++ b/405/ops_codes.txt @@ -0,0 +1 @@ +Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Permanente Tracheotomie[5-312.0 ] Partielle Exzision [erkrankter] harter und weicher Gaumen[5-272.1 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 B] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Großflächige Spalthautdeckung am Unterarm[5-902.48 L] Entnahme Lappen osteomyokutan oder osteofasziokutan mikrovaskuläre Anastomosierung Unterarm[5-858.33 L] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Transplantat[5-295.04 ] \ No newline at end of file diff --git a/405/patient_clinical_data.json b/405/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..c1102202adf4633aae7355601c3f0d42336dfc45 --- /dev/null +++ b/405/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 57, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 62, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/405/patient_pathological_data.json b/405/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..16a23798a6565af4e67a60e93c8258c5ef4d9de2 --- /dev/null +++ b/405/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "405", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 1.0 +} \ No newline at end of file diff --git a/405/surgery_description.txt b/405/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..39b4bbefa143c98de1511089aa9b09b34bb8336c --- /dev/null +++ b/405/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Resection of the floor of the skull; Defect coverage, Free flap (Radial), Tracheotomy diff --git a/405/surgery_report.txt b/405/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1fd86b320374ca04eb856005d9c8c32f55dbdb1d --- /dev/null +++ b/405/surgery_report.txt @@ -0,0 +1 @@ +After appropriate preparation, start with the tracheostomy. After skin incision, preparation of the anterior tracheal wall. Opening between the 2nd and 3rd tracheal clasp. Insertion of the mucocutaneous anastomosis. Subsequent retubation of the patient. Then start with the transoral tumor resection. After exposure of the tumor, which has invaded the left posterior palatal arch and extends just to the uvula, it is resected. The resection includes the uvula on the right side and extends upwards to about 1 cm to the hard palate. The entire left soft palate is then successively removed under visualization up to the middle tonsil pole. The specimen is then sent in oriented on a cork plate for a frozen section histological examination. Here, the left margin in the area of the tonsil lobe is still affected by CIS, as is the resection margin in the area of the posterior hypopharyngeal wall. Large resections are taken, which subsequently prove to be tumor-free. Subsequently, transition to neck dissection on the left side. Here, the vascular nerve sheath of the sternocleidomastoid muscle is exposed after a skin incision and sharp transection of the platysma. Regions I-V are then removed while preserving all non-lymphatic structures. Macroscopically, cervical metastasis is often suspected. The carotid bifurcation is then completely exposed and the internal carotid artery is followed cranially to the radiologically visible metastasis on the atlas arch. After cutting the digastric muscle, also cut the stylohyoid muscle and expose the entire length of the styloid process. The metastasis is exposed craniomedially, which is successively dissected free and finally removed with complete skeletonization of the internal carotid artery up to its entry into the base of the skull. Subsequent transition to neck dissection on the right side. Here a metastasis is seen in region IIb, which has infiltrated the vein as well as the muscle and nerve. The internal jugular vein is removed caudally and the specimen is removed together with the sternocleidomastoid muscle, dissecting the accessorius nerve up to the digastric muscle. The internal jugular vein is then also ligated at the base of the skull and finally removed. The hypoglossal nerve and vagus nerve can of course be preserved. Insertion of a Redon suction drain and two-layer wound closure on the right side. Subsequent transition to the opposite side and creation of an opening in the hypopharynx in the area of the submandibular lobe after skeletonization of the hypoglossal nerve. Elevation of the radial lobe graft through and . Marking of the radial artery, palpatory identification of the distal radial artery and the ulnar artery. Marking of the flap borders (7 x 3 cm) on the distal forearm proximal to the flexor retinaculum with an S-shaped incision extending proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue from the proximal side. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the graft margin. Identification of the external ramus, the superficial ramus, the radial nerve, protection of these. Exposure of the vascular pedicle between the flexor carpi radialis muscle and brachioradialis muscle, here dissection of the pedicle without damaging the vessel to be anastomosed. The incision is now made along the flap borders on the distal forearm. Elevation of the radial portion while leaving the fascia of the brachioradialis tendon intact. Subsequent dissection down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the forearm fascia of the graft edge up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendinous tissue on the flexor tendon and to protect the ulnar artery. Identification of the artery. Clamp the radial artery with a vascular clamp. After 5 minutes under good pulsoxymetric oxygen saturation measured on the thumb (approx. 98 %), the vessels are removed with subsequent ligation with silk thread after the flap umbrella has already been completely detached from the base. Perforators were treated with a vessel clip. Bipolar coagulation. The radial nerve in the median side of the brachioradialis muscle remains intact. The brachial artery was exposed as well as the recurrent radial artery, ulnar artery, radial artery and interosseous artery; the radial artery was removed while sparing all of the above vessels and ligated using a silk thread. Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm and defect coverage of the graft with split skin from the right thigh in a typical manner with stitching of the split skin. Application of a wound dressing, forearm splint, completion of graft elevation without complications. Subsequent insertion of the radial artery flap graft into the defect and suturing to the soft palate and the base of the tongue combined transorally and transcervically. After removal of the facial artery at the lower jaw, the arterial anastomosis is performed with the radial artery. The venous anastomosis is formed by 2 arm veins in a Wend-to-side manner to the internal jugular vein. Finally, insertion of a Redon suction drain and a drainage flap, multi-layer wound closure. Re-intubation of the patient onto an 8-gauge tracheostomy tube. Sterile wound dressing and end of the operation. Transfer of the patient to anesthesia. Conclusion: Resection of an oropharyngeal carcinoma on the left side with primary reconstruction using a free-stemmed radial flap from the left forearm with primary coverage of the defect on the left forearm with split skin from the right thigh. On the left side, selective neck dissection of regions I to V with removal of a metastasis in front of the atlas arch. On the right side, radical neck dissection with infiltration of the internal jugular vein, the accessorius nerve and the sternocleidomastoid muscle. \ No newline at end of file diff --git a/406/InvasionFront_CD3_block21_x3_y9_patient406_0.json b/406/InvasionFront_CD3_block21_x3_y9_patient406_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f2e74736f4d49674742f9d7ac7eccaebb790815b --- /dev/null +++ b/406/InvasionFront_CD3_block21_x3_y9_patient406_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13143.0, + "Centroid Y µm": 33257.4, + "Num Detections": 19762, + "Num Negative": 17561, + "Num Positive": 2201, + "Positive %": 11.14, + "Num Positive per mm^2": 941.82 + } +} \ No newline at end of file diff --git a/406/InvasionFront_CD3_block21_x4_y9_patient406_1.json b/406/InvasionFront_CD3_block21_x4_y9_patient406_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a610506f63acf5ad6e705f12c12925192ef0b202 --- /dev/null +++ b/406/InvasionFront_CD3_block21_x4_y9_patient406_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15816.6, + "Centroid Y µm": 33182.4, + "Num Detections": 12168, + "Num Negative": 11533, + "Num Positive": 635, + "Positive %": 5.219, + "Num Positive per mm^2": 401.37 + } +} \ No newline at end of file diff --git a/406/InvasionFront_CD8_block21_x3_y9_patient406_0.json b/406/InvasionFront_CD8_block21_x3_y9_patient406_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d6de3d75b2dea4513c0fd69631bc0856cc6a431 --- /dev/null +++ b/406/InvasionFront_CD8_block21_x3_y9_patient406_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 22238.2, + "Num Detections": 19707, + "Num Negative": 17359, + "Num Positive": 2348, + "Positive %": 11.91, + "Num Positive per mm^2": 984.11 + } +} \ No newline at end of file diff --git a/406/InvasionFront_CD8_block21_x4_y9_patient406_1.json b/406/InvasionFront_CD8_block21_x4_y9_patient406_1.json new file mode 100644 index 0000000000000000000000000000000000000000..da8edd85db9ba47bc133eb35d93105e0888f506d --- /dev/null +++ b/406/InvasionFront_CD8_block21_x4_y9_patient406_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 22138.3, + "Num Detections": 13117, + "Num Negative": 12522, + "Num Positive": 595, + "Positive %": 4.536, + "Num Positive per mm^2": 350.73 + } +} \ No newline at end of file diff --git a/406/TumorCenter_CD3_block21_x3_y9_patient406_0.json b/406/TumorCenter_CD3_block21_x3_y9_patient406_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b445c50462d48810821bad8ca6db9d022613aa22 --- /dev/null +++ b/406/TumorCenter_CD3_block21_x3_y9_patient406_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 25111.7, + "Num Detections": 11435, + "Num Negative": 10393, + "Num Positive": 1042, + "Positive %": 9.112, + "Num Positive per mm^2": 626.35 + } +} \ No newline at end of file diff --git a/406/TumorCenter_CD3_block21_x4_y9_patient406_1.json b/406/TumorCenter_CD3_block21_x4_y9_patient406_1.json new file mode 100644 index 0000000000000000000000000000000000000000..822593794fc2fd265038b93147c582052fe686cd --- /dev/null +++ b/406/TumorCenter_CD3_block21_x4_y9_patient406_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13617.8, + "Centroid Y µm": 25061.7, + "Num Detections": 9773, + "Num Negative": 8088, + "Num Positive": 1685, + "Positive %": 17.24, + "Num Positive per mm^2": 1031.6 + } +} \ No newline at end of file diff --git a/406/TumorCenter_CD8_block21_x3_y9_patient406_0.json b/406/TumorCenter_CD8_block21_x3_y9_patient406_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8701bf6d411433bd53b57948cd2a842dbaeaa439 --- /dev/null +++ b/406/TumorCenter_CD8_block21_x3_y9_patient406_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13018.1, + "Centroid Y µm": 37380.2, + "Num Detections": 18897, + "Num Negative": 17689, + "Num Positive": 1208, + "Positive %": 6.393, + "Num Positive per mm^2": 548.22 + } +} \ No newline at end of file diff --git a/406/TumorCenter_CD8_block21_x4_y9_patient406_1.json b/406/TumorCenter_CD8_block21_x4_y9_patient406_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b5cbfa062ec3c632c97dcfe21f669a16d3c5e237 --- /dev/null +++ b/406/TumorCenter_CD8_block21_x4_y9_patient406_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15516.8, + "Centroid Y µm": 37430.2, + "Num Detections": 16994, + "Num Negative": 15111, + "Num Positive": 1883, + "Positive %": 11.08, + "Num Positive per mm^2": 878.43 + } +} \ No newline at end of file diff --git a/406/history_text.txt b/406/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..d8a44298be7bc7ba9f3dfc5ee3932995013595d7 --- /dev/null +++ b/406/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy <2011>, the patient was diagnosed with a squamous cell carcinoma of the left larynx, which extended into the anterior commissure. Due to the extremely poor adjustability, the indication for a partial laryngectomy from the outside was given. \ No newline at end of file diff --git a/406/icd_codes.txt b/406/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3fc441e4d4825c4aa1cb2d74ab85b413db0db51b --- /dev/null +++ b/406/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 ] \ No newline at end of file diff --git a/406/ops_codes.txt b/406/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..848ea19e31ad7ff4b7fa61190a5c7ed46bed9bde --- /dev/null +++ b/406/ops_codes.txt @@ -0,0 +1 @@ +Chordektomie durch Thyreotomie[5-302.2 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/406/patient_clinical_data.json b/406/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5b72105af42df7d86b3dd780127ad97f9e022be5 --- /dev/null +++ b/406/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 3, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/406/patient_pathological_data.json b/406/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b236298399f78f648bc38cab325bbbd9d14180f3 --- /dev/null +++ b/406/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "406", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G1", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/406/surgery_description.txt b/406/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1cb9dcda0bfd0f5f8f6fd79b2816e690bd0ec29f --- /dev/null +++ b/406/surgery_description.txt @@ -0,0 +1 @@ +Chordectomy through thyrotomy diff --git a/406/surgery_report.txt b/406/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..d7d03671dbd8625868ff4751ce8aa78243f13db7 --- /dev/null +++ b/406/surgery_report.txt @@ -0,0 +1 @@ +After an introductory consultation with the anesthesia colleagues, initially no infiltration of local anesthetic with adrenaline. Zigzag incision prelaryngeal. Dissection in layers down to the prelaryngeal musculature. Cut off several large veins here. Then separate the prelaryngeal musculature in the midline and dissect the thyroid cartilage. Exposure of the ligamentum conicum and the cricoid cartilage. Subsequent exposure of the thyroid isthmus, which is undermined and dissected after coagulation. Then expose the anterior surface of the trachea. Then incision of the perichondrium on the thyroid cartilage. This is then pushed off to the right and left. Then open the thyroid cartilage with the wheel in the midline. Transverse incision of the ligamentum conicum. Then insertion of retractors into the outer edge of the wound and into the thyrofissure. An exophytic mass is now visible, which extends into the anterior commissure. The endolarynx was opened paramedially on the right side. Now take a marginal sample in the area of the anterior commissure on the right side, where there is no longer a tumor macroscopically. The tumor is then dissected out at the level of the ligament and in the area of the subglottis from front to back. The endolaryngeal musculature lateral to the vocal cord does not appear to be infiltrated by the tumor. This boundary is therefore respected as the resection boundary. The resection is performed up to the base of the vocal process, where the tumor ends in the area of the posterior commissure. This is followed by careful hemostasis using bipolar coagulation and application of Otriven swabs. Further marginal samples are then taken from the cranial, caudal and dorsal margins and the basal area of deposition. All marginal samples are diagnosed intraoperatively as tumor-free in the frozen section. Therefore, an R0 resection of the specimen can be assumed. Careful hemostasis is performed again. The anterior surface of the trachea is then exposed again. Now incision of the trachea between the 2nd and 3rd cartilage clasp. The 3rd cartilage clasp is then removed as the cartilage here is very fragile. Creation of a tracheostoma with the chondrotome. The tracheostoma is then sutured circularly to the skin. Due to the depth and the short neck, the entire preparation is considerably more difficult. The patient had to be intubated and extubated several times during the creation of the tracheostoma. Finally, the thyrofissure was sutured after 4 drill holes were made in the area of the thyroid cartilage. Insertion of a laryngeal keel, which was also fixed with 2 sutures. Then suture of the conic ligament. Now move several muscle layers over the thyroid cartilage, which are also sutured in the midline. Beforehand, insert a wound flap that extends to the keel. Then two-layer wound closure and application of a pressure bandage. At the end of the operation, the patient is then intubated with an 8 mm tracheoflex tracheostomy tube. The procedure is then completed after a final consultation with the anesthesia colleagues. After waking up without any problems, the patient is then transferred to the intensive care unit for monitoring. \ No newline at end of file diff --git a/407/InvasionFront_CD3_block1_x3_y12_patient407_0.json b/407/InvasionFront_CD3_block1_x3_y12_patient407_0.json new file mode 100644 index 0000000000000000000000000000000000000000..be89d91ca64c50625855cf1afc45b88fd3b3ca7c --- /dev/null +++ b/407/InvasionFront_CD3_block1_x3_y12_patient407_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10819.3, + "Centroid Y µm": 31783.2, + "Num Detections": 22723, + "Num Negative": 19915, + "Num Positive": 2808, + "Positive %": 12.36, + "Num Positive per mm^2": 1109.8 + } +} \ No newline at end of file diff --git a/407/InvasionFront_CD3_block1_x4_y12_patient407_1.json b/407/InvasionFront_CD3_block1_x4_y12_patient407_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eba0c1a6c5fba3e0626c52bf024c441fba7e8093 --- /dev/null +++ b/407/InvasionFront_CD3_block1_x4_y12_patient407_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13268.0, + "Centroid Y µm": 31883.1, + "Num Detections": 21569, + "Num Negative": 18820, + "Num Positive": 2749, + "Positive %": 12.75, + "Num Positive per mm^2": 1113.8 + } +} \ No newline at end of file diff --git a/407/InvasionFront_CD8_block1_x3_y12_patient407_0.json b/407/InvasionFront_CD8_block1_x3_y12_patient407_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42662e493e2e7b44d7fb27b3db7c889cba4237b8 --- /dev/null +++ b/407/InvasionFront_CD8_block1_x3_y12_patient407_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11044.2, + "Centroid Y µm": 30159.0, + "Num Detections": 22267, + "Num Negative": 16822, + "Num Positive": 5445, + "Positive %": 24.45, + "Num Positive per mm^2": 2130.8 + } +} \ No newline at end of file diff --git a/407/InvasionFront_CD8_block1_x4_y12_patient407_1.json b/407/InvasionFront_CD8_block1_x4_y12_patient407_1.json new file mode 100644 index 0000000000000000000000000000000000000000..24844b7c524cb14c364c851f9df0d793f91a68bf --- /dev/null +++ b/407/InvasionFront_CD8_block1_x4_y12_patient407_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13517.8, + "Centroid Y µm": 30284.0, + "Num Detections": 20416, + "Num Negative": 12560, + "Num Positive": 7856, + "Positive %": 38.48, + "Num Positive per mm^2": 3134.6 + } +} \ No newline at end of file diff --git a/407/TumorCenter_CD8_block1_x3_y12_patient407_0.json b/407/TumorCenter_CD8_block1_x3_y12_patient407_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bf27751c6a848e58fbe64a3c68811af87e8ca08b --- /dev/null +++ b/407/TumorCenter_CD8_block1_x3_y12_patient407_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14117.5, + "Centroid Y µm": 38904.4, + "Num Detections": 21622, + "Num Negative": 16107, + "Num Positive": 5515, + "Positive %": 25.51, + "Num Positive per mm^2": 2206.2 + } +} \ No newline at end of file diff --git a/407/TumorCenter_CD8_block1_x4_y12_patient407_1.json b/407/TumorCenter_CD8_block1_x4_y12_patient407_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e602993e7b2e28a4465cfa851ab48894dd836fb --- /dev/null +++ b/407/TumorCenter_CD8_block1_x4_y12_patient407_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16491.3, + "Centroid Y µm": 38854.4, + "Num Detections": 17739, + "Num Negative": 13107, + "Num Positive": 4632, + "Positive %": 26.11, + "Num Positive per mm^2": 2286.1 + } +} \ No newline at end of file diff --git a/407/history_text.txt b/407/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/407/icd_codes.txt b/407/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/407/ops_codes.txt b/407/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/407/patient_clinical_data.json b/407/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ecaafd20592047444bf9d2911d63bf893f14058b --- /dev/null +++ b/407/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "carboplatin + Docetaxel", + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/407/patient_pathological_data.json b/407/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..35106cc4d4beed5ca5aaad9e25da08e246df7261 --- /dev/null +++ b/407/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "407", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 30, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/407/surgery_description.txt b/407/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6beb6d2fde2bff9e8ba15dba51c582f55875667c --- /dev/null +++ b/407/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Defect coverage, Free flap (Radial) diff --git a/407/surgery_report.txt b/407/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/408/InvasionFront_CD3_block17_x5_y11_patient408_0.json b/408/InvasionFront_CD3_block17_x5_y11_patient408_0.json new file mode 100644 index 0000000000000000000000000000000000000000..53f780a501113350473db4bc2e7b45e3fa3ce1a9 --- /dev/null +++ b/408/InvasionFront_CD3_block17_x5_y11_patient408_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15616.7, + "Centroid Y µm": 32782.6, + "Num Detections": 19386, + "Num Negative": 17317, + "Num Positive": 2069, + "Positive %": 10.67, + "Num Positive per mm^2": 992.95 + } +} \ No newline at end of file diff --git a/408/InvasionFront_CD3_block17_x6_y11_patient408_1.json b/408/InvasionFront_CD3_block17_x6_y11_patient408_1.json new file mode 100644 index 0000000000000000000000000000000000000000..47579fd2efc99993e873bea5d0d7758e715e91d7 --- /dev/null +++ b/408/InvasionFront_CD3_block17_x6_y11_patient408_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 32857.6, + "Num Detections": 23573, + "Num Negative": 19863, + "Num Positive": 3710, + "Positive %": 15.74, + "Num Positive per mm^2": 1416.4 + } +} \ No newline at end of file diff --git a/408/InvasionFront_CD8_block17_x5_y11_patient408_0.json b/408/InvasionFront_CD8_block17_x5_y11_patient408_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5ba78990011a6f638fe7c346723f55ea1ff96f78 --- /dev/null +++ b/408/InvasionFront_CD8_block17_x5_y11_patient408_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16141.5, + "Centroid Y µm": 27460.5, + "Num Detections": 20427, + "Num Negative": 19485, + "Num Positive": 942, + "Positive %": 4.612, + "Num Positive per mm^2": 435.35 + } +} \ No newline at end of file diff --git a/408/InvasionFront_CD8_block17_x6_y11_patient408_1.json b/408/InvasionFront_CD8_block17_x6_y11_patient408_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c07db72897c0fe55dd2dbef198fbdb92b8d09d97 --- /dev/null +++ b/408/InvasionFront_CD8_block17_x6_y11_patient408_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18615.1, + "Centroid Y µm": 27485.4, + "Num Detections": 21204, + "Num Negative": 19716, + "Num Positive": 1488, + "Positive %": 7.018, + "Num Positive per mm^2": 668.58 + } +} \ No newline at end of file diff --git a/408/TumorCenter_CD3_block17_x5_y11_patient408_0.json b/408/TumorCenter_CD3_block17_x5_y11_patient408_0.json new file mode 100644 index 0000000000000000000000000000000000000000..60f7181be940e5ddca256a538a9172822beb2856 --- /dev/null +++ b/408/TumorCenter_CD3_block17_x5_y11_patient408_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15766.7, + "Centroid Y µm": 27335.5, + "Num Detections": 15894, + "Num Negative": 13532, + "Num Positive": 2362, + "Positive %": 14.86, + "Num Positive per mm^2": 1161.9 + } +} \ No newline at end of file diff --git a/408/TumorCenter_CD3_block17_x6_y11_patient408_1.json b/408/TumorCenter_CD3_block17_x6_y11_patient408_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b59aa8e57fe0563f36c530b9a84aeda0f633ed20 --- /dev/null +++ b/408/TumorCenter_CD3_block17_x6_y11_patient408_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18090.4, + "Centroid Y µm": 27460.5, + "Num Detections": 16394, + "Num Negative": 14208, + "Num Positive": 2186, + "Positive %": 13.33, + "Num Positive per mm^2": 1123.3 + } +} \ No newline at end of file diff --git a/408/TumorCenter_CD8_block17_x5_y11_patient408_0.json b/408/TumorCenter_CD8_block17_x5_y11_patient408_0.json new file mode 100644 index 0000000000000000000000000000000000000000..171eccdb01c2cc93958b59fe20f7121c29150e9e --- /dev/null +++ b/408/TumorCenter_CD8_block17_x5_y11_patient408_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18790.1, + "Centroid Y µm": 40953.3, + "Num Detections": 26021, + "Num Negative": 25470, + "Num Positive": 551, + "Positive %": 2.118, + "Num Positive per mm^2": 212.28 + } +} \ No newline at end of file diff --git a/408/TumorCenter_CD8_block17_x6_y11_patient408_1.json b/408/TumorCenter_CD8_block17_x6_y11_patient408_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8bb7cf2e739610da9a458f45d7ee0f8f063fcbbb --- /dev/null +++ b/408/TumorCenter_CD8_block17_x6_y11_patient408_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21238.8, + "Centroid Y µm": 40978.3, + "Num Detections": 21704, + "Num Negative": 20907, + "Num Positive": 797, + "Positive %": 3.672, + "Num Positive per mm^2": 338.94 + } +} \ No newline at end of file diff --git a/408/history_text.txt b/408/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..445d437c4d98244116cc0e98b220aff8a66c8399 --- /dev/null +++ b/408/history_text.txt @@ -0,0 +1 @@ +Preoperative findings: Large mass in the area of the vocal fold level on the right side, extending from the arytenoid cartilage to the anterior commissure, reaching far to the side. Histologically confirmed to be a squamous cell carcinoma. \ No newline at end of file diff --git a/408/icd_codes.txt b/408/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..85f8d69a523b5441a0c7d4ca8e7a70fed0274e88 --- /dev/null +++ b/408/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 R] \ No newline at end of file diff --git a/408/ops_codes.txt b/408/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5b508f4d896241bc9f7875f26c433bfac8e53f15 --- /dev/null +++ b/408/ops_codes.txt @@ -0,0 +1 @@ +Frontolaterale Kehlkopfteilresektion[5-302.7 ] \ No newline at end of file diff --git a/408/patient_clinical_data.json b/408/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b61b7d6dba513700788050afbe5872b65adcb1b1 --- /dev/null +++ b/408/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 53, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/408/patient_pathological_data.json b/408/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f84e26c5327098dca898a5af25e7203c03f49140 --- /dev/null +++ b/408/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "408", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": null, + "infiltration_depth_in_mm": 5.0 +} \ No newline at end of file diff --git a/408/surgery_description.txt b/408/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c0b7036df80b8e15bde0128c19c82714d77075a0 --- /dev/null +++ b/408/surgery_description.txt @@ -0,0 +1 @@ +Frontolateral laryngeal partial resection diff --git a/408/surgery_report.txt b/408/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7fc47f5b3cdf5269c701c774578eb743abea62ff --- /dev/null +++ b/408/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. Initial adjustment with the small bore tube. Attempt to expose this tumor for laser resection. It turns out that due to the size of the tumor and the difficulty of exposure, it is not possible to resect the tumor in this way. As a result, the decision was made to proceed externally. Repositioning of the patient. Insertion of a gastric tube. Abjuring and covering the neck after local anesthesia has been administered prelaryngeally. Transverse skin incision in a skin fold. Cut through the subcutaneous tissue. Exposure of the linea alba. Exposure of the infrahyoid musculature. Exposure of the thyroid cartilage, cricoid cartilage and ligamentum conicum. Coagulation of the cricothyroid artery. Separation of the conic ligament. Opening of the thyroid cartilage in the median line with the wheel. The tumor can be seen in the area of the right vocal fold, which extends to the anterior commissure; suspicious tissue also extends to the left commissure, which is first removed completely so that the left vocal fold is visible. This tissue is sent for a frozen section examination and is assessed as tumor-free. Before opening the larynx, a small lump was removed above the ligamentum conicum. This was the delphic lymph node. This was also sent for a frozen section examination and was also tumor-free. Removal of the perichondrium in the area of the thyroid cartilage on the right front. Careful resection of the tumor. As far as can be assessed intraoperatively in healthy tissue. The resection includes the morgue sinus, the subglottic slope and also includes the tip of the vocal process of the arytenoid cartilage. As far as can be assessed intraoperatively, the resection of the tumor is complete. Prior to resection, fluid was injected into the tissue surrounding the tumor in order to lift the tumor from the base. Careful hemostasis. Removal of representative margin samples at all levels. These marginal samples are all found to be tumor-free. Closure of the larynx with three Vicryl sutures after careful hemostasis. Rinsing with water and hydrogen. Reconstruction of the ligamentum conicum. Closure of the infrahyoid muscles above the thyroid cartilage. Insertion of a flap. Wound closure in layers. Application of a pressure dressing. Final consultation with the anesthetist. Completion of the procedure. \ No newline at end of file diff --git a/409/InvasionFront_CD3_block19_x5_y1_patient409_0.json b/409/InvasionFront_CD3_block19_x5_y1_patient409_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8983feb59044970299716c2d82d98fbe2e404793 --- /dev/null +++ b/409/InvasionFront_CD3_block19_x5_y1_patient409_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17865.5, + "Centroid Y µm": 5322.2, + "Num Detections": 19805, + "Num Negative": 18475, + "Num Positive": 1330, + "Positive %": 6.715, + "Num Positive per mm^2": 611.17 + } +} \ No newline at end of file diff --git a/409/InvasionFront_CD3_block19_x6_y1_patient409_1.json b/409/InvasionFront_CD3_block19_x6_y1_patient409_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6e882c9dd1917e8ad8b910c8579fccb13bf2167 --- /dev/null +++ b/409/InvasionFront_CD3_block19_x6_y1_patient409_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20389.2, + "Centroid Y µm": 5372.2, + "Num Detections": 19555, + "Num Negative": 17915, + "Num Positive": 1640, + "Positive %": 8.387, + "Num Positive per mm^2": 775.87 + } +} \ No newline at end of file diff --git a/409/InvasionFront_CD8_block19_x5_y1_patient409_0.json b/409/InvasionFront_CD8_block19_x5_y1_patient409_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4eb17348203d4ab1092215c02c8f4d7d510b4c1b --- /dev/null +++ b/409/InvasionFront_CD8_block19_x5_y1_patient409_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16902.4, + "Centroid Y µm": 12604.7, + "Num Detections": 20181, + "Num Negative": 19957, + "Num Positive": 224, + "Positive %": 1.11, + "Num Positive per mm^2": 98.64 + } +} \ No newline at end of file diff --git a/409/InvasionFront_CD8_block19_x6_y1_patient409_1.json b/409/InvasionFront_CD8_block19_x6_y1_patient409_1.json new file mode 100644 index 0000000000000000000000000000000000000000..57da7912c92bc85b41bb96cf1cd1333659e57db4 --- /dev/null +++ b/409/InvasionFront_CD8_block19_x6_y1_patient409_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19589.6, + "Centroid Y µm": 12675.7, + "Num Detections": 21345, + "Num Negative": 21127, + "Num Positive": 218, + "Positive %": 1.021, + "Num Positive per mm^2": 95.83 + } +} \ No newline at end of file diff --git a/409/TumorCenter_CD3_block19_x5_y1_patient409_0.json b/409/TumorCenter_CD3_block19_x5_y1_patient409_0.json new file mode 100644 index 0000000000000000000000000000000000000000..242ffd5cb799b1282f63d786a9761f90cbf9b903 --- /dev/null +++ b/409/TumorCenter_CD3_block19_x5_y1_patient409_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14956.4, + "Centroid Y µm": 2845.9, + "Num Detections": 22107, + "Num Negative": 21625, + "Num Positive": 482, + "Positive %": 2.18, + "Num Positive per mm^2": 192.93 + } +} \ No newline at end of file diff --git a/409/TumorCenter_CD3_block19_x6_y1_patient409_1.json b/409/TumorCenter_CD3_block19_x6_y1_patient409_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a5d71e22e293f192dda8a60b43d4819491229bf4 --- /dev/null +++ b/409/TumorCenter_CD3_block19_x6_y1_patient409_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17460.7, + "Centroid Y µm": 2509.5, + "Num Detections": 20092, + "Num Negative": 19841, + "Num Positive": 251, + "Positive %": 1.249, + "Num Positive per mm^2": 107.48 + } +} \ No newline at end of file diff --git a/409/TumorCenter_CD8_block19_x5_y1_patient409_0.json b/409/TumorCenter_CD8_block19_x5_y1_patient409_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a7e5d4d6a2768a101b9e487cfe86a569d42193e4 --- /dev/null +++ b/409/TumorCenter_CD8_block19_x5_y1_patient409_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18273.2, + "Centroid Y µm": 13112.0, + "Num Detections": 25615, + "Num Negative": 24656, + "Num Positive": 959, + "Positive %": 3.744, + "Num Positive per mm^2": 374.06 + } +} \ No newline at end of file diff --git a/409/TumorCenter_CD8_block19_x6_y1_patient409_1.json b/409/TumorCenter_CD8_block19_x6_y1_patient409_1.json new file mode 100644 index 0000000000000000000000000000000000000000..94e933f10860a3501aec75933c8e30f8e1f081e1 --- /dev/null +++ b/409/TumorCenter_CD8_block19_x6_y1_patient409_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20871.1, + "Centroid Y µm": 13163.7, + "Num Detections": 19394, + "Num Negative": 18751, + "Num Positive": 643, + "Positive %": 3.315, + "Num Positive per mm^2": 279.36 + } +} \ No newline at end of file diff --git a/409/history_text.txt b/409/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7e1eed086b6a23d8e9fc12da14984947e40f0906 --- /dev/null +++ b/409/history_text.txt @@ -0,0 +1 @@ +Patient with an externally histologically proven G2 squamous cell carcinoma on the left in the area of the glottis with possible perforation of the thyroid cartilage in the preoperative computer tomogram and indication for the above-mentioned measures. \ No newline at end of file diff --git a/409/icd_codes.txt b/409/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..052a14170998e2e80dca93c824b7e71944b0428c --- /dev/null +++ b/409/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 R] \ No newline at end of file diff --git a/409/ops_codes.txt b/409/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..14a3033a8c7c7f478e94053a9169f0edf3bb95f2 --- /dev/null +++ b/409/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] \ No newline at end of file diff --git a/409/patient_clinical_data.json b/409/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cc77e13f46dcd146a2acb9d697e8ea77bbaee67d --- /dev/null +++ b/409/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 76, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 52, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/409/patient_pathological_data.json b/409/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..99b67d5523cb3a25ab87cb6cc6b52bb44dd68847 --- /dev/null +++ b/409/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "409", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 54, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/409/surgery_description.txt b/409/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..01620affded61870c918a6bd1264100c90a10239 --- /dev/null +++ b/409/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Bilateral neck dissection, Provox prosthesis, Panendoscopy diff --git a/409/surgery_report.txt b/409/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7305084a61340ff92c248b0c9e876bf765f31bd1 --- /dev/null +++ b/409/surgery_report.txt @@ -0,0 +1 @@ +Anaesthesia was initially induced by the anaesthesia colleagues and a tracheoscopy was performed using 0° optics. Unobtrusive conditions in the area of the trachea up to the carina. Subsequently, difficult endotracheal intubation and positioning of the patient by the surgeon due to the very narrow endolaryngeal conditions. Flexible endoscopy of the oesophagus and stomach. Advance the endoscope to the stomach. Inconspicuous conditions up to the pylorus. Endoscope inversion and inspection of the esophagogastric junction. Inconspicuous conditions there. Withdrawal of the endoscope and inspection of the esophagus. Inconspicuous conditions there. A laryngoscopy was then performed using a Kleinsasser C-tube. This revealed a circularly growing glottic laryngeal carcinoma extending to the arytenoid region on both sides and into the anterior commissure with slight spread into the subglottis without infiltration of the supraglottis. Otherwise, the piriform sinuses on both sides, the posterior hypopharyngeal wall and the postcricoid region as well as the esophageal inlet were unremarkable. The posterior wall of the oropharynx and the lateral walls were endoscopically unremarkable. The base of the tongue was unremarkable on endoscopy and palpation. Thus, and taking into account the clinical findings (SL arrest on the left and SL immobility on the right), the indication for complete laryngectomy and neck dissection on both sides was determined. Application of local anesthesia cervically on both sides and medially. Skin ablation and sterile draping. Creation of a subplatysmal apron flap in the typical manner. Exposure of the cricoid cartilage and thyroid isthmus, undermining of the same, exposure of the anterior wall of the trachea and incision between the 3rd and 4th tracheal cartilage clasp. Fixation of the tracheal margin at the skin edge and reintubation on a size 8 laryngectomy tube. Subsequent dissection along the anterior sternocleidomastoid muscle on the right side. Exposure of the capsule of the submandibular gland, exposure of the accessorius nerve and the digaster muscle (venter posterior). Exposure of the omohyoid muscle and exposure of the cervical vascular sheath from caudal to cranial, successive dissection along the cervical vascular sheath while protecting it and the plexus branches. Removal of the posterior and anterior neck specimen while protecting the above-mentioned structures. Hemostasis there using bipolar coagulation. Dry conditions. Repositioning of the patient to perform a neck dissection on the left side. Dissection along the anterior border of the sternocleidomastoid muscle on the left side. Exposure of the accessorius nerve in depth. Exposure of the posterior venter of the digaster muscle. Exposure of the omohyoid muscle, exposure of the cervical vascular sheath. Dissection along the internal jugular vein from caudal to cranial. Successive removal of the posterior and anterior neck preparation while protecting the above-mentioned structures and the plexus branches. Hemostasis there using bipolar coagulation and subsequent concentration in the cervical median area. Separation of the prelaryngeal muscles in the midline. Exposure of multiple, conspicuous nodes in region VI. These are then removed and sent for final histology. The prelaryngeal musculature is then cut at the level of the hyoid bone using a monopolar knife. Exposure of the epiglottis after transection of the hyoepiglottic ligament. Exposure of the free edge of the epiglottis. Opening of the pharyngeal lumen and downward retraction of the epiglottis with the hyoid bone. Mucosal incision along the free epiglottis edges and the aryepiglottic folds on both sides. Followed by a scalpel incision along the posterior edge of the thyroid cartilage on both sides. Subperichondral preparation and protection of the piriform sinuses on both sides. Subsequently, union of both vertical mucosal incisions in the area of the plica aryepiglottica on both sides in the postcricoid area. Further submucosal dissection while sparing the mucosa and the submucosa of the anterior esophageal wall. Further dissection between the trachea and esophagus. Dissection at this level and placement of the laryngectomy specimen between the 2nd and 3rd tracheal cartilage clasp. Two marginal samples (tracheal resection margin, anterior wall of the left piriform sinus) were sent for frozen section - both were found to be tumor-free by the pathology colleagues. Subsequently, paramedian myotomy of the cricopharyngeal muscle on the left side and partial resection of the caudal part of the sternocleidomastoid muscle on both sides. Subsequently, a size 10 Provox-Vega was placed retrograde without any problems, followed by a four-layer pharyngeal suture (mucosa, submucosa, pharyngeal muscle layer, infrahyoid muscles). This results in complete pharyngeal closure. Subsequently, to secure the pharyngeal suture, insertion of cut pieces of TachoSil along the entire pharyngeal suture. Hemostasis using bipolar coagulation. Knock back the subplatysmal apron flap and fix its caudal edge to the tracheostoma. Platysma suture. Single button skin suture. Application of a pressure bandage and completion of the procedure without complications. Please provide nutrition via the inserted nasogastric feeding tube for the next 12 days and then perform X-ray gavage. The patient received Unacid 3 g intravenously as a single shot intraoperatively. \ No newline at end of file diff --git a/410/InvasionFront_CD3_block11_x5_y10_patient410_0.json b/410/InvasionFront_CD3_block11_x5_y10_patient410_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0af0be40eb42b36477ea2da572d588eafe41ba37 --- /dev/null +++ b/410/InvasionFront_CD3_block11_x5_y10_patient410_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 24112.2, + "Num Detections": 10108, + "Num Negative": 9145, + "Num Positive": 963, + "Positive %": 9.527, + "Num Positive per mm^2": 743.57 + } +} \ No newline at end of file diff --git a/410/InvasionFront_CD3_block11_x6_y10_patient410_1.json b/410/InvasionFront_CD3_block11_x6_y10_patient410_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d51794b000a7fd40ee520491ae18fb7c8f11c333 --- /dev/null +++ b/410/InvasionFront_CD3_block11_x6_y10_patient410_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18540.2, + "Centroid Y µm": 24087.2, + "Num Detections": 9053, + "Num Negative": 8375, + "Num Positive": 678, + "Positive %": 7.489, + "Num Positive per mm^2": 687.67 + } +} \ No newline at end of file diff --git a/410/InvasionFront_CD8_block11_x5_y10_patient410_0.json b/410/InvasionFront_CD8_block11_x5_y10_patient410_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30141d27ca96a5d9e53600cd2c2951a9d96422b4 --- /dev/null +++ b/410/InvasionFront_CD8_block11_x5_y10_patient410_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18763.9, + "Centroid Y µm": 35351.1, + "Num Detections": 2879, + "Num Negative": 2738, + "Num Positive": 141, + "Positive %": 4.898, + "Num Positive per mm^2": 315.97 + } +} \ No newline at end of file diff --git a/410/InvasionFront_CD8_block11_x6_y10_patient410_1.json b/410/InvasionFront_CD8_block11_x6_y10_patient410_1.json new file mode 100644 index 0000000000000000000000000000000000000000..851f47a0baedf0fbf11cf17215addc672a52c128 --- /dev/null +++ b/410/InvasionFront_CD8_block11_x6_y10_patient410_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21036.3, + "Centroid Y µm": 35331.8, + "Num Detections": 2713, + "Num Negative": 2693, + "Num Positive": 20, + "Positive %": 0.7372, + "Num Positive per mm^2": 47.22 + } +} \ No newline at end of file diff --git a/410/TumorCenter_CD3_block11_x5_y10_patient410_0.json b/410/TumorCenter_CD3_block11_x5_y10_patient410_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b086496eb95b2df5eac161abf7ba645a44db57c6 --- /dev/null +++ b/410/TumorCenter_CD3_block11_x5_y10_patient410_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18577.7, + "Centroid Y µm": 25143.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/410/TumorCenter_CD3_block11_x6_y10_patient410_1.json b/410/TumorCenter_CD3_block11_x6_y10_patient410_1.json new file mode 100644 index 0000000000000000000000000000000000000000..10c366aafd6af31c61db3e6a6d67599a9cf1c649 --- /dev/null +++ b/410/TumorCenter_CD3_block11_x6_y10_patient410_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21063.8, + "Centroid Y µm": 25061.7, + "Num Detections": 6938, + "Num Negative": 5321, + "Num Positive": 1617, + "Positive %": 23.31, + "Num Positive per mm^2": 1600.4 + } +} \ No newline at end of file diff --git a/410/TumorCenter_CD8_block11_x5_y10_patient410_0.json b/410/TumorCenter_CD8_block11_x5_y10_patient410_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0fa1a6627cae6a925220c647d61f420b3e60a7c1 --- /dev/null +++ b/410/TumorCenter_CD8_block11_x5_y10_patient410_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 24711.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/410/TumorCenter_CD8_block11_x6_y10_patient410_1.json b/410/TumorCenter_CD8_block11_x6_y10_patient410_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b02f3b162ee958605848c98169a6d648025383ae --- /dev/null +++ b/410/TumorCenter_CD8_block11_x6_y10_patient410_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18940.0, + "Centroid Y µm": 24761.9, + "Num Detections": 5708, + "Num Negative": 4742, + "Num Positive": 966, + "Positive %": 16.92, + "Num Positive per mm^2": 1186.0 + } +} \ No newline at end of file diff --git a/410/history_text.txt b/410/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e742117d62ee92fb5b5b26d39e5728c93cf4605f --- /dev/null +++ b/410/history_text.txt @@ -0,0 +1 @@ +During a panendoscopy <2012>, the patient was diagnosed with a cT2 cN0 oral cavity carcinoma in the right paramedian soft palate. In our interdisciplinary tumor conference, primary surgical treatment was recommended. Immediately preoperatively, sonography revealed a cN0 neck status. CT showed no evidence of distant metastasis. In the case of a preoperatively determined implant fracture following cervical spine surgery, the procedure regarding positioning was discussed with the trauma surgery and neurosurgery colleagues on several occasions. Positioning within the natural range of motion was classified as safe. \ No newline at end of file diff --git a/410/icd_codes.txt b/410/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4d1dcbef33712e70bb537f5f0d27e46c0f20ebcd --- /dev/null +++ b/410/icd_codes.txt @@ -0,0 +1 @@ +Uvulakarzinom[C05.2 ] \ No newline at end of file diff --git a/410/ops_codes.txt b/410/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..eaa37be187fd7f619aff78a830411ebe50096dd4 --- /dev/null +++ b/410/ops_codes.txt @@ -0,0 +1 @@ +Gastrostomie: Perkutan-endoskopisch (PEG)[5-431.2 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Radikale zervikale Lymphadenektomie [Neck dissection]: Selektiv (funktionell): 5 Regionen[5-403.04 B] Temporäre Weichteildeckung: Anlage oder Wechsel eines Systems zur Vakuumversiegelung: An Haut und Unterhaut[5-916.a0 ] Exzision und Destruktion des (erkrankten) harten und weichen Gaumens: Exstirpation, total, transoral[5-272.2 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] \ No newline at end of file diff --git a/410/patient_clinical_data.json b/410/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1e2241941a66f35c3af4242e8f9c1cb057fe582e --- /dev/null +++ b/410/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 61, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/410/patient_pathological_data.json b/410/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d0133038c9306212ef80516d646d7c5114f3d0c3 --- /dev/null +++ b/410/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "410", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 42, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/410/surgery_description.txt b/410/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f718445f8ef7816f69ecda3223e1d2e11ba83475 --- /dev/null +++ b/410/surgery_description.txt @@ -0,0 +1 @@ +Transoral resection with defect coverage, Free flap (Radial), Neck dissection, PEG placement diff --git a/410/surgery_report.txt b/410/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..1b4e927c6aed9df2f6729aa82a1a518aeeb0acc3 --- /dev/null +++ b/410/surgery_report.txt @@ -0,0 +1 @@ +After preparing and positioning the patient, the PEG is first inserted. Insertion with the gastroscope under laryngoscopic control. Easy pre-laryngoscopy into the stomach. Excellent diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. Then careful positioning with moderate hyperextension, starting with transoral tumor resection. First perform pharyngoscopy. An exophytic, exulcerous tumor is seen in the right paramedian soft palate. This infiltrates the soft palate completely. Only small remnants on the left side, growth into the soft palate dorsally. However, no dorsal mucosal perforation. On the right side, circumscribed infiltration of the upper tonsil pole and the posterior palatal arch. Otherwise, no further extension by palpation and inspection. The tumor is now resected with a macroscopic safety margin of approx. 1.5 cm. Resection of the tumor macroscopically clearly in toto. When releasing the soft palate, good control of the posterior surface is also possible, here too maintaining the safety distance. Isolation to the upper tonsil pole, subtotal removal of the anterior palatal arch. Partial resection of the posterior palatal arch. This safely resects the carcinoma. If the upper pole of the tonsil is infiltrated, the tonsillectomy is performed using the classic dissection technique. Removal of the tonsil at the lower tonsil pole. Certainly no tumor growth here. The tumor is sent as a thread-marked specimen for frozen section diagnostics and is diagnosed here as a squamous cell carcinoma resected in sano. The result was an almost total soft palate defect with a defect in the area of the tonsil lobe, therefore a graft defect measuring up to 10 x 6 cm was measured. Multiple checks and, in the event of blood dryness, initially turning to neck dissection on the left side. A very short neck is seen. Difficult visualization conditions due to lack of hyperextensibility with short anatomical relationships. Skin incision submandibularly and at the anterior edge of the sternocleidomastoid muscle, cutting through skin and subcutaneous tissue. Exposure and dissection of the platysma. Creation of a platysma flap. Exposure and later ligation of the external jugular vein with a very oblique course. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the cervical artery, the superior thyroid artery and the hypoglossal nerve. Exposure of the internal jugular vein. Careful free preparation. Level 2 shows a slightly enlarged but non-adherent lymph node measuring approx. 2 x 1 cm in the area of the jugulo-facial angle. Exposure of the accessorius nerve. Evacuation of the accessorius triangle with careful protection of the nerve and evacuation of level 5 with careful protection of the cervical plexus branches and caudal protection of the lymph vessel structures. Final inspection. In dry conditions after resection of the neck dissection en bloc. In dry conditions, insertion of a 10-gauge Redon drain and careful two-layer wound closure. Repositioning and parallel neck dissection of the right side and elevation of the radialis graft from the left forearm. First turn to the neck dissection. Correspondingly to the opposite side, make the skin incision. Cut through skin and subcutaneous tissue. Exposure of a distal part of the strong external jugular vein, which tapers significantly towards the submandibular region. Preservation of the vessel. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. The anterior region shows clear scarring in this case following transcervical cervical spine surgery. Release of the anterior neck preparation with careful protection of a deep facial vein branch. Exposure of the very slender superior thyroid artery. Exposure of the hypoglossal nerve and the cervical artery. Dissection of the internal jugular vein. Several macroscopically enlarged lymph nodes are visible in levels 2 and 3. Also non-adherent visualization of the accessorius nerve. Release of the accessorius triangle with careful protection of the nerve and release of level 5 with careful protection of the cervical plexus structures. Overall, difficult preparation conditions on both sides due to the anatomical conditions and the difficult positioning. After careful inspection with dry wound conditions, the digastric muscle is resected. Exposure of the carotid bulb and the division of the carotid artery. Exposure of the external carotid artery with the superior thyroid artery, facial artery and occipital artery. Cranial dissection along the artery. Exposure of the styloid under enoral inspection. Performing the pharyngotomy in the area of the tonsil lobe on the right. Widening of the pharyngotomy under control of the vascular nerve structures. However, creation of a tunnel a good two transverse fingers wide. Subsequent insertion of the radialis graft without any problems. To lift the radialis graft. After marking the graft with a special soft palate configuration. Perform the tourniquet. Cut around the graft. Exposure of the brachioradialis muscle, a right constant cephalic vein does not exist here. Expose, secure and protect the superficial radial nerve ramus. Exposure of the distal vascular pedicle. Deposition after ligation, strictly subfascial release. Exposure of the flexor carpi ulnar. Strictly subfascial dissection with clipping of outgoing vessels. After complete elevation of the graft, isolate the vascular pedicle. A relatively stable larger vein can be visualized in the cranial part of the graft. This is dissected proximally to the specimen and opens into the cupital vein. There is a strong bridge between the accompanying veins of the radial artery and the cupital system, which is why the vein is included. The very slender anterior interosseous artery must be clipped. Securing the ulnar artery. A very strong vessel here. Isolate the graft on a strong cupital vein and the radial artery. Reopening of the tourniquet. Immediate regular graft and hand perfusion. Meticulous hemostasis and, after removal of the graft, removal of the full-thickness skin graft from the groin and careful two-layer wound closure. A vacuum sealing dressing is then applied and the stretcher splint is placed in the functional position. For full-thickness skin harvesting from the left groin. For this purpose, cutting of a 12 x 6 cm full-thickness skin graft with strict cutaneous elevation. Subcutaneous undermining and mobilization and strong multi-layer wound closure under moderate tension after insertion of a 10 Redon drain. Now turn to the insertion of the graft. After placing sutures in the area of the dorsal soft palate and towards the nasopharynx, insertion of the graft. The situation here is somewhat difficult with a relatively thick subcutaneous fat layer. Overall, however, a good fit. Complete coverage of the tonsil lobe and the soft palate defect. If the conditions are intact, turn to the vascular anastomosis. Conditioning of the graft vessels. In comparison, the artery is most likely to be equivalent in caliber to the facial artery. Therefore preparation of the vessel. Deposition after clipping. Careful conditioning of the facial artery and somewhat more difficult with a relatively small vessel, but finally good and sufficient anastomosis with 8.0 Ethilon. After reopening, immediate venous return and regular graft perfusion. Due to the positioning, the caudally very strong external jugular vein appears to be well suited for conditioning the vein cranial clipping, there is good flow on the vein, therefore preparation for anastomosis. Measurement of a size 4.0 coupler and problem-free performance of the venous anastomosis with the coupler system. After reopening the clamps, immediate regular graft perfusion and regular pedicle pulsation. After checking the wound, insertion of a 10 Redon drain. Splinting of the drainage with 3.0 Vicryl and careful two-layer wound closure. Multiple enoral inspections of the graft and, in the case of regular vitality with slim enoral conditions, no tracheotomy and completion of the procedure after the patient had been repositioned without any indication of complications. Conclusion: Intraoperative R0 resected cT2 oral cavity carcinoma intraoperative reactive lymphadenopathy differential diagnosis cN+ neck status. Depending on the histological findings, planning of adjuvant therapy if necessary. Postoperative meticulous flap monitoring by enoral inspection. Avoidance of pressure dressings, especially on the right cervical side in the case of vein anastomization to the external jugular vein. The patient received intraoperative i.V. antibiotics with Sobelin 600 mg for penicillin allergy; please continue this for 24 hours postoperatively. If the graft heals properly, a gradual diet can be started from the 8th postoperative day. \ No newline at end of file diff --git a/411/InvasionFront_CD3_block10_x1_y12_patient411_0.json b/411/InvasionFront_CD3_block10_x1_y12_patient411_0.json new file mode 100644 index 0000000000000000000000000000000000000000..87e9a5db11968e1a9a50266f45996aa757751aa4 --- /dev/null +++ b/411/InvasionFront_CD3_block10_x1_y12_patient411_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4357.0, + "Centroid Y µm": 34852.2, + "Num Detections": 24967, + "Num Negative": 23573, + "Num Positive": 1394, + "Positive %": 5.583, + "Num Positive per mm^2": 519.1 + } +} \ No newline at end of file diff --git a/411/InvasionFront_CD3_block10_x2_y12_patient411_1.json b/411/InvasionFront_CD3_block10_x2_y12_patient411_1.json new file mode 100644 index 0000000000000000000000000000000000000000..06237e6d0dab60971b8b6602ef4a2548bf9f5071 --- /dev/null +++ b/411/InvasionFront_CD3_block10_x2_y12_patient411_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6663.1, + "Centroid Y µm": 35095.6, + "Num Detections": 21861, + "Num Negative": 19578, + "Num Positive": 2283, + "Positive %": 10.44, + "Num Positive per mm^2": 950.94 + } +} \ No newline at end of file diff --git a/411/InvasionFront_CD8_block10_x1_y12_patient411_0.json b/411/InvasionFront_CD8_block10_x1_y12_patient411_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65470e5d881acf4c7524264029840960f2a5ed80 --- /dev/null +++ b/411/InvasionFront_CD8_block10_x1_y12_patient411_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5372.2, + "Centroid Y µm": 36230.8, + "Num Detections": 24575, + "Num Negative": 24251, + "Num Positive": 324, + "Positive %": 1.318, + "Num Positive per mm^2": 121.79 + } +} \ No newline at end of file diff --git a/411/InvasionFront_CD8_block10_x2_y12_patient411_1.json b/411/InvasionFront_CD8_block10_x2_y12_patient411_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f5b5f7da5080617077a5f7ac97846746526c1a4 --- /dev/null +++ b/411/InvasionFront_CD8_block10_x2_y12_patient411_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7695.9, + "Centroid Y µm": 36180.8, + "Num Detections": 21807, + "Num Negative": 20532, + "Num Positive": 1275, + "Positive %": 5.847, + "Num Positive per mm^2": 532.57 + } +} \ No newline at end of file diff --git a/411/TumorCenter_CD3_block10_x1_y12_patient411_0.json b/411/TumorCenter_CD3_block10_x1_y12_patient411_0.json new file mode 100644 index 0000000000000000000000000000000000000000..768e38a8efd018d1c18ebb561d3b9e7652374bf1 --- /dev/null +++ b/411/TumorCenter_CD3_block10_x1_y12_patient411_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6893.6, + "Centroid Y µm": 28581.1, + "Num Detections": 9628, + "Num Negative": 9410, + "Num Positive": 218, + "Positive %": 2.264, + "Num Positive per mm^2": 198.47 + } +} \ No newline at end of file diff --git a/411/TumorCenter_CD3_block10_x2_y12_patient411_1.json b/411/TumorCenter_CD3_block10_x2_y12_patient411_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c985795ec89d83490e6c9767707dbe3731e755e --- /dev/null +++ b/411/TumorCenter_CD3_block10_x2_y12_patient411_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9270.1, + "Centroid Y µm": 28959.7, + "Num Detections": 20310, + "Num Negative": 18147, + "Num Positive": 2163, + "Positive %": 10.65, + "Num Positive per mm^2": 955.9 + } +} \ No newline at end of file diff --git a/411/TumorCenter_CD8_block10_x1_y12_patient411_0.json b/411/TumorCenter_CD8_block10_x1_y12_patient411_0.json new file mode 100644 index 0000000000000000000000000000000000000000..95384598b0306ff3404afc41c8cb94c66fdb9b7b --- /dev/null +++ b/411/TumorCenter_CD8_block10_x1_y12_patient411_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4772.5, + "Centroid Y µm": 30583.8, + "Num Detections": 16517, + "Num Negative": 16066, + "Num Positive": 451, + "Positive %": 2.731, + "Num Positive per mm^2": 223.28 + } +} \ No newline at end of file diff --git a/411/TumorCenter_CD8_block10_x2_y12_patient411_1.json b/411/TumorCenter_CD8_block10_x2_y12_patient411_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54391f11336e9580e4f13622baada63c90f0db7f --- /dev/null +++ b/411/TumorCenter_CD8_block10_x2_y12_patient411_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7196.2, + "Centroid Y µm": 30383.9, + "Num Detections": 19568, + "Num Negative": 17725, + "Num Positive": 1843, + "Positive %": 9.418, + "Num Positive per mm^2": 814.79 + } +} \ No newline at end of file diff --git a/411/history_text.txt b/411/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/411/icd_codes.txt b/411/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..37561459eae7c68e06a4a4dc544988473861288b --- /dev/null +++ b/411/icd_codes.txt @@ -0,0 +1 @@ +Carcinoma in situ: Lippe, Mundhöhle und Pharynx[D00.0 ] \ No newline at end of file diff --git a/411/ops_codes.txt b/411/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..d20ecb9478b769e14e4ffed9cf54a440a2e668d9 --- /dev/null +++ b/411/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Lokale Exzision Mundhöhle[5-273.x R] \ No newline at end of file diff --git a/411/patient_clinical_data.json b/411/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..70648662ff18d4fc7bef813c220a41e15e6acafc --- /dev/null +++ b/411/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 59, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 50, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/411/patient_pathological_data.json b/411/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..570604472d06819d9251363d9a920b0e4a112f35 --- /dev/null +++ b/411/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "411", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 38, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "RX", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/411/surgery_description.txt b/411/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a30e53bf35d4a808e41440ec7230be70df1781d2 --- /dev/null +++ b/411/surgery_description.txt @@ -0,0 +1 @@ +Re-resection, Panendoscopy diff --git a/411/surgery_report.txt b/411/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..60ee9b3f01b66676b522d8b2297869237eaf1003 --- /dev/null +++ b/411/surgery_report.txt @@ -0,0 +1 @@ +Initially induction of anesthesia and transoral endotracheal intubation using a glidescope by the anesthesia colleagues and positioning of the patient by the surgeon. Adjustment of the endolarynx using a Kleinsasser C-tube. The subglottis, glottis and supraglottis are unremarkable. On hypopharyngoscopy, the piriform sinuses on both sides, the posterior wall of the hypopharynx and the postcricoid region were also unremarkable. The posterior wall of the oropharynx and the lateral walls were unremarkable. The oral cavity was then adjusted using a McIvor spatula. In the area of the cranial part of the right anterior palatal arch, an irritation-free scar was found. The findings are incised at a distance of 1 cm in all directions using an electric needle and scissors and sent in for final histological processing with suture marking. Hemostasis using bipolar coagulation and completion of the procedure without complications. \ No newline at end of file diff --git a/412/InvasionFront_CD3_block20_x3_y4_patient412_0.json b/412/InvasionFront_CD3_block20_x3_y4_patient412_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b2ea154a78ce0a28a0ec09d2183b31aed2a728bb --- /dev/null +++ b/412/InvasionFront_CD3_block20_x3_y4_patient412_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12668.3, + "Centroid Y µm": 9994.7, + "Num Detections": 20713, + "Num Negative": 18841, + "Num Positive": 1872, + "Positive %": 9.038, + "Num Positive per mm^2": 769.28 + } +} \ No newline at end of file diff --git a/412/InvasionFront_CD3_block20_x4_y4_patient412_1.json b/412/InvasionFront_CD3_block20_x4_y4_patient412_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fb82ef14172dc97988dd725725dc12e684f571a6 --- /dev/null +++ b/412/InvasionFront_CD3_block20_x4_y4_patient412_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15266.9, + "Centroid Y µm": 10169.6, + "Num Detections": 22762, + "Num Negative": 20904, + "Num Positive": 1858, + "Positive %": 8.163, + "Num Positive per mm^2": 720.52 + } +} \ No newline at end of file diff --git a/412/InvasionFront_CD8_block20_x3_y4_patient412_0.json b/412/InvasionFront_CD8_block20_x3_y4_patient412_0.json new file mode 100644 index 0000000000000000000000000000000000000000..42fbcc5a2a02eeb42c3eecd4638f06e842de07b0 --- /dev/null +++ b/412/InvasionFront_CD8_block20_x3_y4_patient412_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11493.9, + "Centroid Y µm": 10094.7, + "Num Detections": 21108, + "Num Negative": 20220, + "Num Positive": 888, + "Positive %": 4.207, + "Num Positive per mm^2": 371.9 + } +} \ No newline at end of file diff --git a/412/InvasionFront_CD8_block20_x4_y4_patient412_1.json b/412/InvasionFront_CD8_block20_x4_y4_patient412_1.json new file mode 100644 index 0000000000000000000000000000000000000000..04b2be352c2c865869066eb0c9133fb4c9fd7523 --- /dev/null +++ b/412/InvasionFront_CD8_block20_x4_y4_patient412_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 10294.5, + "Num Detections": 21836, + "Num Negative": 20904, + "Num Positive": 932, + "Positive %": 4.268, + "Num Positive per mm^2": 386.67 + } +} \ No newline at end of file diff --git a/412/TumorCenter_CD3_block20_x3_y4_patient412_0.json b/412/TumorCenter_CD3_block20_x3_y4_patient412_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a3d5a059c75e63a1a776e94fb65a7746db98de88 --- /dev/null +++ b/412/TumorCenter_CD3_block20_x3_y4_patient412_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11374.7, + "Centroid Y µm": 9509.2, + "Num Detections": 20801, + "Num Negative": 20286, + "Num Positive": 515, + "Positive %": 2.476, + "Num Positive per mm^2": 200.11 + } +} \ No newline at end of file diff --git a/412/TumorCenter_CD3_block20_x4_y4_patient412_1.json b/412/TumorCenter_CD3_block20_x4_y4_patient412_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d22405413ef458eda024073fcd5a7b57649b73aa --- /dev/null +++ b/412/TumorCenter_CD3_block20_x4_y4_patient412_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13870.5, + "Centroid Y µm": 9506.2, + "Num Detections": 20893, + "Num Negative": 20571, + "Num Positive": 322, + "Positive %": 1.541, + "Num Positive per mm^2": 133.02 + } +} \ No newline at end of file diff --git a/412/TumorCenter_CD8_block20_x3_y4_patient412_0.json b/412/TumorCenter_CD8_block20_x3_y4_patient412_0.json new file mode 100644 index 0000000000000000000000000000000000000000..028d948fd833c50e0461adf171b9c83dd613c5e4 --- /dev/null +++ b/412/TumorCenter_CD8_block20_x3_y4_patient412_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10619.4, + "Centroid Y µm": 10019.7, + "Num Detections": 25813, + "Num Negative": 23752, + "Num Positive": 2061, + "Positive %": 7.984, + "Num Positive per mm^2": 785.35 + } +} \ No newline at end of file diff --git a/412/TumorCenter_CD8_block20_x4_y4_patient412_1.json b/412/TumorCenter_CD8_block20_x4_y4_patient412_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5a5a5896cb269611450d4c2e3f763fd6e79027c4 --- /dev/null +++ b/412/TumorCenter_CD8_block20_x4_y4_patient412_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 9919.7, + "Num Detections": 23823, + "Num Negative": 22417, + "Num Positive": 1406, + "Positive %": 5.902, + "Num Positive per mm^2": 570.52 + } +} \ No newline at end of file diff --git a/412/history_text.txt b/412/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..cfd34d02d7cf1a1e313a457de4a912e2ba39e61f --- /dev/null +++ b/412/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT1a G2 cN0 glottic laryngeal carcinoma on the right and a current indication for panendoscopy as well as restoration of the findings in the course of a transoral microlaryngoscopic laser resection. The findings were discussed in detail with the patient preoperatively. \ No newline at end of file diff --git a/412/icd_codes.txt b/412/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/412/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/412/ops_codes.txt b/412/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6cb2d7606bc2d3e1de3a769f498d398ad181299d --- /dev/null +++ b/412/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie: Mit starrem Instrument: Ohne weitere Maßnahmen[1-620.10 ] Diagnostische Laryngoskopie: Mikrolaryngoskopie[1-610.2 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Exzision, mikrolaryngoskopisch[5-300.2 ] Exzision und Destruktion von erkranktem Gewebe des Larynx: Stripping einer Stimmlippe, mikrolaryngoskopisch[5-300.7 ] \ No newline at end of file diff --git a/412/patient_clinical_data.json b/412/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..e1be14f353f2a87a383489528e759d8b2b26c613 --- /dev/null +++ b/412/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/412/patient_pathological_data.json b/412/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..df044a4357c81818abc8752ea46db8804f7cd5dc --- /dev/null +++ b/412/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "412", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/412/surgery_description.txt b/412/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..2b0f46edd12bb0044ac14bd35ce429b2ca867f65 --- /dev/null +++ b/412/surgery_description.txt @@ -0,0 +1 @@ +Transoral microlaryngoscopic laser resection diff --git a/412/surgery_report.txt b/412/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..7ad076c6bad888745773b597d8b5232a27b0824c --- /dev/null +++ b/412/surgery_report.txt @@ -0,0 +1 @@ +Anesthesia induction by the anesthesia colleagues and performance of a rigid tracheoscopy using O° optics. Inconspicuous conditions in the area of the trachea up to the carina. Subsequent transoral endotracheal intubation using a laser tube, tube fixation and positioning of the patient by the surgeon. A flexible oesophagogastroscopy is then performed using an endoscope, which is advanced to the stomach under visualization. Slightly polypoid mucosal changes in the area of the entire stomach in the sense of chronic gastritis, otherwise no evidence of an exophytic mass or unstable mucosal changes. Endoscopic inversion and inspection of the esophageal junction, inconspicuous conditions there. Then withdraw the endoscope and inspect the esophagus. Inconspicuous conditions there. Then perform a rigid pharyngo- and laryngoscopy using a Kleinsasser C-tube. The posterior wall of the hypopharynx and the esophageal entrance, the piriform sinuses on both sides, the posterior wall of the oropharynx and the side walls were also unremarkable. The base of the tongue was unremarkable on endoscopy and palpation. The endolarynx was then adjusted using a Kleinsasser C-tube. In the area of the right vocal fold, an exophytic mass covered with rough mucosa was found, starting directly anterior to the vocal process and extending posteriorly to the anterior commissure, but leaving out the anterior part of the left vocal fold, thus cT1a glottic laryngeal carcinoma on the right. Set the laser beam to 4 watts in continuous mode and successively move around the glottic change at a wide distance. The specimen is removed in toto and sent in for final histology with a suture marker (anteriorly towards the anterior commissure). Four marginal samples were taken (supraglottic towards the pocket fold, subglottic slope, posterior towards the vocal process, anterior towards the anterior commissure), which are sent for intraoperative frozen section examination. The intraoperative frozen section examination reveals in situ carcinoma in the marginal sample "supraglottic towards the pocket fold" as well as chronic inflammatory changes in the marginal sample "subglottic slope" (still requiring clarification there). A resection is therefore performed in the supraglottic area ("supraglottic resection") and a second marginal sample is taken there ("2nd supraglottic marginal sample"). The same procedure is followed in the subglottis. A post-resectate is taken there ("post-resectate subglottis") and a second subglottic marginal sample ("2nd marginal sample subglottis") is taken. Hemostasis using swabs soaked in Suprarenin. Repeated inspection and administration of SDH 250 mg intravenously. Removal of all laryngeal swabs and completion of the procedure under dry conditions. Conclusion: This was a transoral, microlaryngoscopic laser-assisted tumor resection of a cT1a G2 squamous cell carcinoma of the right vocal fold. Please note final histology and schedule a follow-up microlaryngoscopy in 8 weeks. \ No newline at end of file diff --git a/413/InvasionFront_CD3_block13_x3_y8_patient413_0.json b/413/InvasionFront_CD3_block13_x3_y8_patient413_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9aab5fbb23b964714f211bbc802766e4ed58fdad --- /dev/null +++ b/413/InvasionFront_CD3_block13_x3_y8_patient413_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 19214.8, + "Num Detections": 14424, + "Num Negative": 13518, + "Num Positive": 906, + "Positive %": 6.281, + "Num Positive per mm^2": 503.45 + } +} \ No newline at end of file diff --git a/413/InvasionFront_CD3_block13_x4_y8_patient413_1.json b/413/InvasionFront_CD3_block13_x4_y8_patient413_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3b795283fc7170966aee021ee1eb16c202624ff4 --- /dev/null +++ b/413/InvasionFront_CD3_block13_x4_y8_patient413_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13492.9, + "Centroid Y µm": 19089.9, + "Num Detections": 8964, + "Num Negative": 8395, + "Num Positive": 569, + "Positive %": 6.348, + "Num Positive per mm^2": 490.87 + } +} \ No newline at end of file diff --git a/413/InvasionFront_CD8_block13_x3_y8_patient413_0.json b/413/InvasionFront_CD8_block13_x3_y8_patient413_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c868d9c28d12ab84a981368cdc4019f2ab3a4f4e --- /dev/null +++ b/413/InvasionFront_CD8_block13_x3_y8_patient413_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11843.7, + "Centroid Y µm": 20938.9, + "Num Detections": 14711, + "Num Negative": 14091, + "Num Positive": 620, + "Positive %": 4.215, + "Num Positive per mm^2": 341.93 + } +} \ No newline at end of file diff --git a/413/InvasionFront_CD8_block13_x4_y8_patient413_1.json b/413/InvasionFront_CD8_block13_x4_y8_patient413_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e2d39ac061dcd2cb088e05d1d67498910f46af8b --- /dev/null +++ b/413/InvasionFront_CD8_block13_x4_y8_patient413_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14417.4, + "Centroid Y µm": 21013.9, + "Num Detections": 17404, + "Num Negative": 16535, + "Num Positive": 869, + "Positive %": 4.993, + "Num Positive per mm^2": 407.85 + } +} \ No newline at end of file diff --git a/413/TumorCenter_CD3_block13_x3_y8_patient413_0.json b/413/TumorCenter_CD3_block13_x3_y8_patient413_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6bd9c9064b1815a9fa94bc6e6ba07ae9bcf1713c --- /dev/null +++ b/413/TumorCenter_CD3_block13_x3_y8_patient413_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11543.9, + "Centroid Y µm": 26261.1, + "Num Detections": 16562, + "Num Negative": 15913, + "Num Positive": 649, + "Positive %": 3.919, + "Num Positive per mm^2": 291.17 + } +} \ No newline at end of file diff --git a/413/TumorCenter_CD3_block13_x4_y8_patient413_1.json b/413/TumorCenter_CD3_block13_x4_y8_patient413_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6cae26f391a6517820ccd44335d8d7cf3fe3e5b0 --- /dev/null +++ b/413/TumorCenter_CD3_block13_x4_y8_patient413_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 26461.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/413/TumorCenter_CD8_block13_x3_y8_patient413_0.json b/413/TumorCenter_CD8_block13_x3_y8_patient413_0.json new file mode 100644 index 0000000000000000000000000000000000000000..12d099ef29b08233daf78b6ac614f0b06fa14455 --- /dev/null +++ b/413/TumorCenter_CD8_block13_x3_y8_patient413_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12418.4, + "Centroid Y µm": 19914.5, + "Num Detections": 18076, + "Num Negative": 17753, + "Num Positive": 323, + "Positive %": 1.787, + "Num Positive per mm^2": 145.65 + } +} \ No newline at end of file diff --git a/413/TumorCenter_CD8_block13_x4_y8_patient413_1.json b/413/TumorCenter_CD8_block13_x4_y8_patient413_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a4ed4494aa082088d9efc043b92f124f2685041c --- /dev/null +++ b/413/TumorCenter_CD8_block13_x4_y8_patient413_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14792.2, + "Centroid Y µm": 19564.6, + "Num Detections": 14912, + "Num Negative": 14348, + "Num Positive": 564, + "Positive %": 3.782, + "Num Positive per mm^2": 320.11 + } +} \ No newline at end of file diff --git a/413/history_text.txt b/413/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..83b6ae65f9d237b3ef22488b48b57de1d0d4d3e8 --- /dev/null +++ b/413/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed carcinoma in the area of the left tongue cT2-3. Therefore, the above-mentioned surgery is indicated. There is already a history of PEG placement in the pre-panendoscopy. \ No newline at end of file diff --git a/413/icd_codes.txt b/413/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/413/ops_codes.txt b/413/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..170c3669873196f18499226a1573dad5041ef28e --- /dev/null +++ b/413/ops_codes.txt @@ -0,0 +1 @@ +Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Permanente Tracheostomaanlage[5-312.0 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] \ No newline at end of file diff --git a/413/patient_clinical_data.json b/413/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..116f675f9cbca63d48abc5016349ab58692613ea --- /dev/null +++ b/413/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 43, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 29, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/413/patient_pathological_data.json b/413/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5a37cf1b2b951c8abc2cc06c9a752a498840e6f9 --- /dev/null +++ b/413/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "413", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 53, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/413/surgery_description.txt b/413/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..543fc41ab03c3e7616bb2b14972850d94f6aab8d --- /dev/null +++ b/413/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Defect coverage, Free flap (Radial) diff --git a/413/surgery_report.txt b/413/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b0c3c772fdc0809cd92f589fd742763d725597ab --- /dev/null +++ b/413/surgery_report.txt @@ -0,0 +1 @@ +Initial transoral tumor resection: insertion of reinforced retractors and placement of the tumor. The carcinoma, which is located in the middle to posterior third of the tongue, infiltrates into the base of the tongue, submucosally and anteriorly submucosally towards the tip of the tongue. The tumor is removed from all sides with a safety margin of 1.5 - 2 cm. A minimal remnant remains in the area of the tip of the tongue, otherwise the entire tongue, parts of the floor of the mouth with extrinsic musculature and parts of the sublingual glands are removed. Also resection of the lingual nerve. The largest part of the base of the tongue also falls backwards. Tumor is thread-marked for frozen section histology. All edges of the specimen are tumor-free in the frozen section. Thus R0 resection. Now transfer to neck dissection: injection of a total of 10 ml Ultracaine 1% with adrenaline into each side of the neck. First neck dissection on the left: Curved skin incision. Exposure of the sternocleidomastoid muscle. Exposure of the cervical vascular sheath. V. jugularis interna, A. carotis communis, A. carotis interna, externa. Visualization of vagus nerve, accessorius nerve, hypoglossal nerve. Visualization of a rich venous plexus with connection between the external jugular vein, which is double and also has connections to the internal jugular vein via the facial vein. Subsequent evacuation of level II to V. The submandibular gland is also resected cranially. A tunnel measuring 3 QF is then created from transoral to transcervical. This is followed by neck dissection on the right side. This is carried out in the same way as on the left side, exposing the structures mentioned. The submandibular gland is left in place. Levels II to IV are removed. Then elevation of the radial lobe: Marking of the defect in the appropriate extent and size. Maximum length 10 cm, maximum width 6.5 to 7 cm. Mark the flap and cut around it, first from the ulnar and then from the radial side. The radial artery is clamped with the clamp without cutting it first. Then cut up to the olecranon and expose the brachioradialis muscle. Exposure of the vascular pedicle. Exposure of the superficial venous system. Overall stable saturation, no drop, constant 100% saturation in the area of the right hand. Subsequent detachment of the flap from the ulnar and radial subfacial side, taking the superficial venous system with it from the radial side. Preservation of the lateral antebrachial nerve. Separation of the radial artery and treatment of this using a puncture ligature and 4-0 prolene distally and proximally. Subsequent elevation of the flap along its deep and superficial pedicle. Outgoing vessels are treated using a clip or bipolar. Connections between the deep and superficial venous system can be visualized and lifted in the crook of the elbow. 2 ends of the cephalic vein can be removed. Likewise the radial artery before the exit of the interosseous artery. The radial vein is removed after confluence in a new division. A vein remains in the area of the brachial or ulnar artery. Flushing of the vessels with heparin solution. Subsequent insertion of the radial artery flap: insertion into the defect. Successive suturing of the flap with 3-0 Vicryl single button sutures. This is achieved without tension while closing the tongue and floor of mouth defect or base of tongue defect and palatal arch defect. The stalk was passed through the already created tunnel into the left side of the neck. After conditioning the vessels, an arterial anastomosis between the facial and radial arteries was performed using Ethilon 8-0 single-button sutures. After opening the clamp, good arterial flow and good venous return. Subsequent venous anastomosis between an outlet from the bundle between the external jugular vein and the facial vein with connection to the internal jugular vein. Coupler size 3 was used for this, followed by a further anastomosis between the other outlet of the cephalic vein and the remaining external jugular vein using coupler 2.5. Good venous return in each case, positive smear phenomenon. This is followed by careful hemostasis of the entire wound area, irrigation with H202 and Ringer's solution. Subsequently, wound closure in layers on both sides of the neck with insertion of a Redon drain in each case. To cover the wound in the area of the right forearm, a piece of skin measuring approx. 11 x 6 cm was removed from the right groin. After ........... of the skin, the wound is closed in layers with the insertion of a Redon drain. The full-thickness skin is then sutured into the defect. This was successful without tension. The wound towards the crook of the elbow is closed in the typical way in layers. The arm is treated with a hydrogel Mepilex dressing. Loose compress dressing on top. Wrap with a absorbent cotton dressing. Then fit a Cramer splint and wrap the forearm with an elastic bandage. Finally, tracheostoma placement: small Kocher collar incision between the neck incisions. Exposure of the infrahyoid musculature, which is split. Exposure of the thyroid isthmus. This is passed underneath, clamped, severed and supplied by means of a puncture ligature. Exposure of the trachea, which is positioned relatively. Extensive skin mobilization to enable better epithelialization. Finally, epithelialization is achieved with relatively little tension in a typical manner. After insertion of the relatively wide Björk flap, insertion of an 8 mm tracheal cannula is possible without any problems. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment that was started intraoperatively for one week. Patient should be fed via PEG, if necessary after swallowing porridge in approx. 7-10 days. Heparin perfusor 500 E/hour, which was started intraoperatively, should be continued for 5 days. Flap control clinically and by means of Doppler at the sites marked by sutures for 5 days according to the scheme. Overall cT2-3 tongue margin carcinoma on the left, suspicious lymph nodes on both sides. Procedure after final histology and discussion in the interdisciplinary tumor conference. \ No newline at end of file diff --git a/414/InvasionFront_CD3_block5_x1_y1_patient414_0.json b/414/InvasionFront_CD3_block5_x1_y1_patient414_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3e343f568fc7f2cc4a1971963e51f183dd55f3dd --- /dev/null +++ b/414/InvasionFront_CD3_block5_x1_y1_patient414_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4197.8, + "Centroid Y µm": 2598.6, + "Num Detections": 21436, + "Num Negative": 21020, + "Num Positive": 416, + "Positive %": 1.941, + "Num Positive per mm^2": 173.15 + } +} \ No newline at end of file diff --git a/414/InvasionFront_CD3_block5_x2_y1_patient414_1.json b/414/InvasionFront_CD3_block5_x2_y1_patient414_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e3b7f4f9316ca5fc34e7f82ff299e5c030701069 --- /dev/null +++ b/414/InvasionFront_CD3_block5_x2_y1_patient414_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6571.5, + "Centroid Y µm": 2548.7, + "Num Detections": 23428, + "Num Negative": 22419, + "Num Positive": 1009, + "Positive %": 4.307, + "Num Positive per mm^2": 393.58 + } +} \ No newline at end of file diff --git a/414/InvasionFront_CD8_block5_x1_y1_patient414_0.json b/414/InvasionFront_CD8_block5_x1_y1_patient414_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8e6f8ed347b59293a8afcbf5abef8cda92547d14 --- /dev/null +++ b/414/InvasionFront_CD8_block5_x1_y1_patient414_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 3198.3, + "Num Detections": 19946, + "Num Negative": 19786, + "Num Positive": 160, + "Positive %": 0.8022, + "Num Positive per mm^2": 70.44 + } +} \ No newline at end of file diff --git a/414/InvasionFront_CD8_block5_x2_y1_patient414_1.json b/414/InvasionFront_CD8_block5_x2_y1_patient414_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7444d461662fbc76414ad5c38e279acb8d90572e --- /dev/null +++ b/414/InvasionFront_CD8_block5_x2_y1_patient414_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 3073.4, + "Num Detections": 20887, + "Num Negative": 20498, + "Num Positive": 389, + "Positive %": 1.862, + "Num Positive per mm^2": 163.49 + } +} \ No newline at end of file diff --git a/414/TumorCenter_CD3_block5_x1_y1_patient414_0.json b/414/TumorCenter_CD3_block5_x1_y1_patient414_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c1e699fb31ce7c41b5658a4ef985220c16c6bae9 --- /dev/null +++ b/414/TumorCenter_CD3_block5_x1_y1_patient414_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5771.9, + "Centroid Y µm": 1899.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/414/TumorCenter_CD3_block5_x2_y1_patient414_1.json b/414/TumorCenter_CD3_block5_x2_y1_patient414_1.json new file mode 100644 index 0000000000000000000000000000000000000000..454d2dd5331c0daa1b3e133c3182f560639316c3 --- /dev/null +++ b/414/TumorCenter_CD3_block5_x2_y1_patient414_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8520.5, + "Centroid Y µm": 2223.8, + "Num Detections": 20514, + "Num Negative": 19818, + "Num Positive": 696, + "Positive %": 3.393, + "Num Positive per mm^2": 281.21 + } +} \ No newline at end of file diff --git a/414/TumorCenter_CD8_block5_x1_y1_patient414_0.json b/414/TumorCenter_CD8_block5_x1_y1_patient414_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1202ce3e3d9dd85cc6388a3f432a42239b71aa40 --- /dev/null +++ b/414/TumorCenter_CD8_block5_x1_y1_patient414_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4072.8, + "Centroid Y µm": 2373.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/414/TumorCenter_CD8_block5_x2_y1_patient414_1.json b/414/TumorCenter_CD8_block5_x2_y1_patient414_1.json new file mode 100644 index 0000000000000000000000000000000000000000..67c9fd679ceb908698dd343ae6e6d77be8a9cc4e --- /dev/null +++ b/414/TumorCenter_CD8_block5_x2_y1_patient414_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6771.4, + "Centroid Y µm": 2473.7, + "Num Detections": 21192, + "Num Negative": 20644, + "Num Positive": 548, + "Positive %": 2.586, + "Num Positive per mm^2": 227.57 + } +} \ No newline at end of file diff --git a/414/history_text.txt b/414/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/414/icd_codes.txt b/414/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..da55c7511d068fc0b0dfe7e6a45d4d38eecf0a89 --- /dev/null +++ b/414/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung Oropharynx mehrere Teilbereiche überlappend[C10.8 L] \ No newline at end of file diff --git a/414/ops_codes.txt b/414/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..16875825cf48afef0fea65d5e2a6b238e559360c --- /dev/null +++ b/414/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 B] Permanente Tracheotomie[5-312.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument sonstige[1-620.1x ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Sonstige diagnostische Ösophagogastroskopie[1-631.x ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] \ No newline at end of file diff --git a/414/patient_clinical_data.json b/414/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8c9d5312110d2a3582e3081bf5be6b72e1f8a091 --- /dev/null +++ b/414/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 52, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 20, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/414/patient_pathological_data.json b/414/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3dbd6ba3a188796fcec36cd74b60cfdc84aec8e2 --- /dev/null +++ b/414/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "414", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/414/surgery_description.txt b/414/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/414/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/414/surgery_report.txt b/414/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..384bd1e38a9def2fbdde8f8df15567c4493dbcc3 --- /dev/null +++ b/414/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesia colleagues. Start with the tracheotomy, after injection, covering and abjodation. Vertical incision from the cricoid cartilage to about 2 cm above the jugulum. Spread the infrahyoid muscles apart. Locating the thyroid isthmus and intermittent ligation of larger veins. Detachment of the thyroid isthmus from the anterior surface of the trachea. Coagulation and transection. Insertion between the second and third tracheal cartilages. Epithelialization of the tracheostoma and reintubation onto an LE tube. Followed by oesophagogastroscopy with problem-free endoscopy up to the stomach and, with good diaphanoscopy, problem-free insertion of a PEG tube using the thread pull-through method in the typical manner. Combined transoral transcervical surgery including left neck dissection now follows: First, positioning of the tumor using a Mc Ivor spatula or mouth retractor. Cut around the tumor with a safety margin of 1-1.5 cm on all cranial sides. The anterior palatal arch and parts of the posterior palatal arch are removed. Resection extends over the alveolar ridge to the lower jaw. Here the tumor is pushed away from the lower jaw, bone is not infiltrated. Neck dissection on the left is then necessary before continuing with the transcervical resection. Typical skin incision. Exposure of sternocleidomastoid muscle, exposure of omohyoid muscle and digastric muscle. Exposure of the internal jugular vein, facial vein, internal carotid artery, external carotid artery. Depiction of the lingual artery, facial artery and superior thyroid artery. Exposure of the hypgoglossal nerve and 'N. accessorius. Level II-V are removed, also taking into account and preserving the branches of the cervical plexus, several cranial lymph node metastases, which are easy to remove. Level II-III lymph node metastases. Subsequent continuation of the tumor resection. Dissection of the digastric muscle. Subsequent removal of the submandibular gland with preservation of the oral branch. Exposure and preservation of the hypoglossal nerve. Snaring of the hypoglossus and snaring of the large vessels using vessel loops. Dissection of the large vessels from the pharyngeal tube. Subsequent dissection from the inside through the pharyngeal tube to the outside under external and internal control. The tumour is gradually mobilized further. Due to the spread of the tumor to the alveolar ridge or lower jaw. The periosteum is pushed off along this line. The inferior alveolar nerve is now seen to be integrated into the tumor and is or must be resected. Resection up to the front of the floor of the mouth with parts of the posterior floor of the mouth. A small part of the base of the tongue is resected. Pharyngeal wall is resected en bloc. Lateral parts of the hyoid bone and the external musculature here are also resected. The hypoglossal nerve can be preserved. The tumor specimen is then removed. This is thread-marked. Additional marginal sample from the soft tissue cranial basal from the area of the pterygoid muscle. Marginal sample from the alveolar ridge in the entire area of the exposed bone at the border to the mucosa of the alveolar ridge. In the frozen section, the preparation and marginal samples are free. Extensive irrigation of the wound area with H202 and Ringer's solution. Hemostasis. Repositioning of the patient for neck dissection. Injection of a total of 12 ml of local anesthetic with adrenaline in the area of the planned incision. Start on the right side. Skin incision extended medially to the front. Subcutaneous preparation. Separation of the platysma. Exposure of the sternocleidomastoid muscle and dissection of its medial side. Visualization and exposure of the accessorius nerve. Exposure of the omohyoid muscle and free dissection of the same up to the hyoid bone. Then exposure of the lower surface of the submandibular gland and elevation of the lateral connective tissue mantle. Exposure of the digastric muscle. Connection of the boundaries now created. Exposure of the vascular nerve sheath and detachment of the lateral neck preparation. Separation of the same. Gradual dissection of the medial neck preparation. Protection of the hypoglossal nerve. Protection of the external jugular vein. Especially in level II on the right side, there are some relatively large, rough and darkly discolored nodules, thus a suspected cN2c neck status. Minutious hemostasis. Redon system. Subcutaneous suture and skin suture. Parallel lifting of the radialis graft . Elevation of the radial forearm flap on the left by : Palpatory identification of the distal radial artery. Marking of the flap boundaries (size) on the distal forearm, proximal to the flexor retinaculum, with an S-shaped incision running proximally into the cubital fossa. Incision of cutaneous and subcutaneous tissue starting proximally. Identification and visualization of the venous confluence in the cubital fossa. Identification of the cephalic vein and dissection of the vein distally with integration into the radial graft margin. Identification of the ramus externus of the radial nerve and elevation of the radial portion, leaving the peritendineum of the tendons of the brachioradialis muscle intact. Subsequent ulnar incision down to the forearm fascia. Incision of the fascia and subsequent subfascial elevation of the ulnar edge of the graft up to the tendon of the flexor carpi radialis muscle. Care is taken to leave the peritendineum on the flexor tendons and to spare the ulnar artery. Identification of the distal radial artery and trial clamping with a vascular clamp. After 5 minutes with good oxygen saturation measured by pulse oximetry (measured on the index finger), the vessels are removed with subsequent ligation (Prolene 6.0). Successive detachment of the flap pedicle from the M. pronator quadratus and M. flexor pollicis longus with ligation of the outgoing perforators using a vessel clip into the cubital fossa. Exposure and protection of the radial nerve on the medial side of the brachioradialis muscle. Exposure of the brachial artery, V. mediana cubiti, A. ulnaris. First removal of the radial artery, then of two veins of the superficial venous system. Vascular ligation by means of a bypass ligature (artery) and vascular clip (veins). Subtle hemostasis in the area of the wound bed using bipolar coagulation forceps. Two-layer wound closure in the area of the proximal forearm. Defect coverage of the graft bed with split skin from the right thigh in the usual manner. Suturing of preparation swabs. Application of a wound dressing and a forearm splint. Completion of the graft lift without complications. Then removal of the radialis graft and suturing of the radialis graft, this is done by placing sutures transcervically and also transorally. Finally, an anastomosis is made between the radial artery and facial artery and facial vein and an outlet from the facial vein. This is successful without any problems. The patient goes to the intensive care unit ventilated. Please check the flap in the usual way. \ No newline at end of file diff --git a/415/InvasionFront_CD3_block9_x5_y2_patient415_0.json b/415/InvasionFront_CD3_block9_x5_y2_patient415_0.json new file mode 100644 index 0000000000000000000000000000000000000000..69c93b8046ac6779307597f3eac71b83066d8a69 --- /dev/null +++ b/415/InvasionFront_CD3_block9_x5_y2_patient415_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18813.1, + "Centroid Y µm": 5833.6, + "Num Detections": 19011, + "Num Negative": 18613, + "Num Positive": 398, + "Positive %": 2.094, + "Num Positive per mm^2": 200.12 + } +} \ No newline at end of file diff --git a/415/InvasionFront_CD3_block9_x6_y2_patient415_1.json b/415/InvasionFront_CD3_block9_x6_y2_patient415_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f72cb0e950919a7d9c6146fe2e1e5b44cab96952 --- /dev/null +++ b/415/InvasionFront_CD3_block9_x6_y2_patient415_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21538.4, + "Centroid Y µm": 5922.0, + "Num Detections": 20343, + "Num Negative": 20023, + "Num Positive": 320, + "Positive %": 1.573, + "Num Positive per mm^2": 144.49 + } +} \ No newline at end of file diff --git a/415/InvasionFront_CD8_block9_x5_y2_patient415_0.json b/415/InvasionFront_CD8_block9_x5_y2_patient415_0.json new file mode 100644 index 0000000000000000000000000000000000000000..577b383eff91936db63ca1c13c3eb3a28f653b9a --- /dev/null +++ b/415/InvasionFront_CD8_block9_x5_y2_patient415_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18115.4, + "Centroid Y µm": 9719.9, + "Num Detections": 23461, + "Num Negative": 22421, + "Num Positive": 1040, + "Positive %": 4.433, + "Num Positive per mm^2": 427.96 + } +} \ No newline at end of file diff --git a/415/InvasionFront_CD8_block9_x6_y2_patient415_1.json b/415/InvasionFront_CD8_block9_x6_y2_patient415_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e2ec4329f8f51f688c164bf22d34e78438fe6294 --- /dev/null +++ b/415/InvasionFront_CD8_block9_x6_y2_patient415_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20839.0, + "Centroid Y µm": 9644.9, + "Num Detections": 23378, + "Num Negative": 22837, + "Num Positive": 541, + "Positive %": 2.314, + "Num Positive per mm^2": 231.58 + } +} \ No newline at end of file diff --git a/415/TumorCenter_CD3_block9_x5_y2_patient415_0.json b/415/TumorCenter_CD3_block9_x5_y2_patient415_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1e769eb7f0313dfbb96d6ce3e48bacded8018b55 --- /dev/null +++ b/415/TumorCenter_CD3_block9_x5_y2_patient415_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16991.0, + "Centroid Y µm": 10819.3, + "Num Detections": 22685, + "Num Negative": 21755, + "Num Positive": 930, + "Positive %": 4.1, + "Num Positive per mm^2": 369.61 + } +} \ No newline at end of file diff --git a/415/TumorCenter_CD3_block9_x6_y2_patient415_1.json b/415/TumorCenter_CD3_block9_x6_y2_patient415_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d5c401b9f68564edbea3a3cbfb52ffbc94907629 --- /dev/null +++ b/415/TumorCenter_CD3_block9_x6_y2_patient415_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19514.7, + "Centroid Y µm": 10944.2, + "Num Detections": 22557, + "Num Negative": 21304, + "Num Positive": 1253, + "Positive %": 5.555, + "Num Positive per mm^2": 518.37 + } +} \ No newline at end of file diff --git a/415/TumorCenter_CD8_block9_x5_y2_patient415_0.json b/415/TumorCenter_CD8_block9_x5_y2_patient415_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ccda5fdf6dfc2aabdffe71bb19fa35ffcea5f3c --- /dev/null +++ b/415/TumorCenter_CD8_block9_x5_y2_patient415_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 5397.1, + "Num Detections": 23673, + "Num Negative": 22879, + "Num Positive": 794, + "Positive %": 3.354, + "Num Positive per mm^2": 318.53 + } +} \ No newline at end of file diff --git a/415/TumorCenter_CD8_block9_x6_y2_patient415_1.json b/415/TumorCenter_CD8_block9_x6_y2_patient415_1.json new file mode 100644 index 0000000000000000000000000000000000000000..983484a93de67fa8ee8661a010e5918d571e1a86 --- /dev/null +++ b/415/TumorCenter_CD8_block9_x6_y2_patient415_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18715.1, + "Centroid Y µm": 5272.2, + "Num Detections": 21254, + "Num Negative": 19874, + "Num Positive": 1380, + "Positive %": 6.493, + "Num Positive per mm^2": 595.16 + } +} \ No newline at end of file diff --git a/415/history_text.txt b/415/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4eaaabb561d8a27598771d24e761e2c26ad638e7 --- /dev/null +++ b/415/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tonsillar carcinoma on the right. At the same time, there is a large neck metastasis, which is already seen from the CT image in the vicinity of the primaries; the internal carotid artery lies between the tumor formations. Infiltration of the carotid artery cannot be detected on CT. \ No newline at end of file diff --git a/415/icd_codes.txt b/415/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c992494d2afea74381f13a24bbdd34eb9e1ddf9f --- /dev/null +++ b/415/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] \ No newline at end of file diff --git a/415/ops_codes.txt b/415/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8ab30eb8871930c6ac31b37ff53cfb68b3ecc749 --- /dev/null +++ b/415/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Transorale partielle Resektion der Zunge mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Radikale Neck dissection in 5 Regionen[5-403.11 R] Selektive Neck dissection in 5 Regionen[5-403.04 L] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 L] \ No newline at end of file diff --git a/415/patient_clinical_data.json b/415/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5273dbc7c8f4e395c265985e74f4b675bce5a6e3 --- /dev/null +++ b/415/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 73, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 4, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/415/patient_pathological_data.json b/415/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f6c405558d5a7a5b77b033e553c84890925e2793 --- /dev/null +++ b/415/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "415", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4b", + "pN_stage": "pN3", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 12.0, + "number_of_resected_lymph_nodes": 49, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R1", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/415/surgery_description.txt b/415/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf085921446279f802d08a1413a24436a24eaebc --- /dev/null +++ b/415/surgery_description.txt @@ -0,0 +1 @@ +Resection, Neck dissection, Tracheotomy, Free flap (Radial) diff --git a/415/surgery_report.txt b/415/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5452d215f83b2631ab66c1271609a1fc093daf08 --- /dev/null +++ b/415/surgery_report.txt @@ -0,0 +1 @@ +Initial consultation with the anesthesiologist. Pharyngoscopy is performed first: The tonsil tumor is seen after insertion of the McIvor blade. This is exophytically limited to the tonsil lobe, but palpation shows deep growth in a cranial and lateral direction and extends to the uvula. Posterior palatal arch also involved. Therefore confirmation of the operation with flap coverage. Placement of the PEG tube in the typical manner. Transoral tumor resection: The tumor is incised on all sides with a safety margin of 1-1.5 cm. The anterior and posterior palatal arches are removed. The soft tissue towards the hard palate is also resected with an appropriate safety margin. The resection also extends deep into the pterygoid muscles. Resection extends to the base of the tongue. Medially up to the posterior pharyngeal wall. The tumor specimen is removed in its entirety. Suture marks are placed. Marginal sample from the uvula and marginal sample from cranial-basal from the soft tissue above the tonsil towards the hard palate. The tumor is resected macroscopically in healthy tissue. However, the frozen section shows tumor infiltrates towards the posterior pharyngeal wall and in almost all areas basally. The marginal specimen of the uvula was healthy. Cranial-basal margin specimen with tumor. The patient is therefore repositioned. Covering of all relevant surgical areas after skin disinfection. Beginning with radical neck dissection on the right: skin incision in typical manner. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the omohyoid muscle and digastric muscle. A large metastatic conglomerate is visible, which has infiltrated the sternocleidomastoid muscle, runs broadly in the direction of the lower parotid pole and towards the base of the skull, and has infiltrated the internal jugular vein. Depiction of the cervical vascular sheath. The external carotid artery as well as the hypoglossal nerve can only be separated from the metastatic conglomerate and preserved with difficulty. Exposure, displacement, neurolysis and re-embedding of the hypoglossal nerve. The internal carotid artery can be easily dissected during the procedure, as can the vagus nerve. This is relocated in the sense of a neurolysis and re-embedded. The internal jugular vein is infiltrated in the upper area. It is placed caudally and ligated twice. Cranially, the lower parotid pole must also be resected as the metastasis grows to this point. All the muscles of the styloid fan are removed. The styloid process must also be resected. Larger parts of the cervical plexus in the cranial part must be resected together with the deep neck muscles, as must of course the sternocleidomastoid muscle. The accessorius nerve is included in the preparation. The V. facialis and V. thyroidea can be preserved. The submandibular gland is also removed. An infiltration of the parapharyngeal space and growth along the internal carotid artery, hypoglossal nerve and vagus nerve can be seen towards the base of the skull. Soft tissue is removed from here, as well as from the area around the styloid process, which was also resected. Tissue is also removed from the right lower pole of the carotid artery. In the frozen section, infiltrations in the skull base margin sample, i.e. around the internal carotid artery and the large cranial nerves. The internal jugular vein was placed very close to the base of the skull and ligated twice. Infiltration by tumor cells, at least microscopically, is also possible here, but was not specifically confirmed by a sample. The tumor is now resected: the facial, superior thyroid and lingual arteries can be preserved. The hypoglossal nerve is also preserved after visualization. Defect in the area of the pharyngeal wall is visualized. The entire pharyngeal wall is resected, including larger parts of the posterior pharyngeal wall. Extensive resection in the area of the pterygoid muscles, which is also resected up to the level of the tube. A marginal sample is taken from the posterior pharyngeal wall from the level of the tube to the hypopharyngeal entrance and sent in labeled with a suture. A marginal sample is also taken caudal-basally from the area of the pharyngeal musculature at the hypopharyngeal entrance. Marginal sample from the cranial-basal area from the area of the remaining pterygoid muscles. A marginal sample was also taken from the transition from the posterior pharyngeal wall to the posterior palatal arch or nasopharyngeal mucosa area. In addition, a marginal sample was taken from the medial pterygoid muscle, which remained on the mandible and was also inconspicuous macroscopically. Infiltrates in the cranial-basal area in the frozen section. Therefore, another extensive soft tissue resection and marginal sample from the pterygoid muscle area next to the tube as well as a mucosal marginal sample with an extensive soft tissue mantle from the palatal mucosa in the hard palate. No more infiltrates here. Overall, an R1 situation is confirmed in the area of the base of the skull, along the cranial nerves and the internal carotid artery. As a final marginal sample, soft tissue was again removed from the entire area, including the spinal column and transition to the mastoid, and sent in for final diagnosis in order to obtain an overview of the extent of the R1 situation. R1 situation certainly also despite R0 situation after marginal samples in the area of the paratubular soft tissue in the pterygoid muscles and soft tissue remaining there. Overall now large defect from the nasopharynx to the hypopharyngeal entrance. Defect coverage using a radial flap is indicated. The defect is measured, resulting in a flap size of approx. 15x10 cm. Irrigation of the wound area with hydrogen and Ringer's solution and extensive hemostasis. Neck dissection on the left side: Here too, as on the opposite side, evacuation level II to V. The internal and external carotid arteries, internal jugular vein, facial vein, vagus nerve, accessorius nerve, hypoglossal nerve and branches of the cervical plexus are all exposed and preserved. The vagus nerve, hypoglossal nerve and vagus nerve are relocated and re-embedded by means of neurolysis. Level II lymph nodes in the cranial region have to be dissected from the jugular vein, but are not infiltrative there. Nevertheless, lymph node metastases are also clinically present here. Tracheostoma creation: Small Kocher collar incision. Exposure through subcutaneous tissue to the infrahyoid musculature. Splitting of these. Exposure of the thyroid isthmus. Undercutting of this, clamping of the same, severing and treatment by means of puncture ligatures. Exposure of the trachea. In the 2nd to 3rd intercartilaginous space, opening of the trachea and creation of a wide pedicled modified Björ flap. This is epithelized in the typical manner. Re-intubation and insertion of an 8 mm Woodbridge tube. Elevation of the forearm flap from the left forearm: Marking of the flap in the required three-dimensional dimension and size. Incision of the flap from ulnar subfascial. Incision in the crook of the elbow. Visualization of the superficial venous system with connection to the deep venous system. Subsequent exposure of the vascular pedicle below the brachioradialis muscle. Then elevation of the flap subfascially from the radial side. Exposure and preservation of the lateral antebrachial cutaneous nerve as far as possible given the size of the flap. Caudal exposure of the V. and A. radialis. After clamping for 10 minutes with good saturation, cut through. Treatment of the stumps using 4.0 Prolene single button sutures. Lift the flap successively along the stalk. Smaller vessels are clipped or bipolar coagulated. Exposure of the interosseous artery in the antecubital fossa. After clamping it for a few minutes, if it is well saturated, it is cut and clipped. Exposure of the entry of the radial artery into the brachial artery. Visualization of the confluence. This is split and not very suitable for anastomosis. Two good venous anastomosis options remain in the area of the cephalic vein. Removal of the flap. Veins are ligated. The brachial artery is supplied with 6.0 Vascufil. Flap is flushed with heparin. Split skin with a thickness of 0.8 mm is removed from the thigh area. Hydrocolloid dressing here. The forearm is primarily closed cranially after extensive hemostasis. Split skin is successively incorporated into the forearm defect. A Vacuseal dressing is applied over this in the typical manner. Suction 75 mmHg. Attachment of the arm. The radial artery flap is inserted into the defect. Successive suturing from transoral and transcervical, partly with the sutures in place. The flap can be sutured in place without tension. Replacement of the pharyngeal side wall and posterior pharyngeal wall and palatal arch. Sutured cranially to the tubal cartilage. The stalk is passed below the hypoglossal nerve into the soft tissues of the neck. The regions at the base of the skull showing the R1 situation were marked with clips beforehand. The vessels were then conditioned. The still outgoing V. facialis and V. thyroidea media are selected as connecting vessels. The facial artery is selected and anastomized with the radial artery after conditioning with 9.0 Ethilon single-button sutures. After opening the clamps, good arterial flow and good venous return. The larger cephalic vein is anastomosed to the facial vein with 4.0 couplers after conditioning. Good venous return after opening the clamps. Positive smear phenomenon. The smaller vein is anastomosed with the V. thyroidea media with a 2.5 mm coupler. Good venous return here too. Positive smear phenomenon. Overall good perfusion of the flap. Careful hemostasis and irrigation of the neck. Wound closure in layers on the right with insertion of two flaps. Application of a pressure bandage. Skin closure on the left with insertion of a Redon drain after extensive hemostasis and irrigation. Application of a pressure bandage. The epithelialized tracheostoma is supplied with an 8 mm tracheostomy tube. This is sutured in place. Wound dressing. Completion of the procedure without complications. Final consultation with the anesthesiologist. Conclusion: Overall cT4 tonsillar carcinoma with almost per continuitatem growth or contact with a very large soft tissue metastasis, which in turn showed infiltrations into the skull base or caudal parotid pole. Almost N3 metastasis on the right, total lymph node metastases on both sides. Overall extensive tumor volume, which justified resection to this extent in view of the HPV-positive status. Postoperative RCT indicated as soon as possible. Patient admitted to the intensive care unit for postoperative monitoring. Antibiotic treatment, which was started intraoperatively with Unacid 3 g, should be continued for one week. Feeding via the inserted PEG tube, after loosening the next day. Flap control enorally or by Doppler for five days. Heparin perfusor, which was started intraoperatively at 500 units/hour, should be continued for five days. X-ray pre-swallow on the 10th day, then diet build-up if necessary. \ No newline at end of file diff --git a/416/InvasionFront_CD3_block20_x3_y12_patient416_0.json b/416/InvasionFront_CD3_block20_x3_y12_patient416_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7d0e22e92e73c4891afe75de092486beb33341ff --- /dev/null +++ b/416/InvasionFront_CD3_block20_x3_y12_patient416_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10769.3, + "Centroid Y µm": 29359.5, + "Num Detections": 22129, + "Num Negative": 21239, + "Num Positive": 890, + "Positive %": 4.022, + "Num Positive per mm^2": 387.08 + } +} \ No newline at end of file diff --git a/416/InvasionFront_CD3_block20_x4_y12_patient416_1.json b/416/InvasionFront_CD3_block20_x4_y12_patient416_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ff6b19eaa171795618c0d7b1d5d6ed3bf04b4989 --- /dev/null +++ b/416/InvasionFront_CD3_block20_x4_y12_patient416_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 29609.3, + "Num Detections": 20098, + "Num Negative": 18888, + "Num Positive": 1210, + "Positive %": 6.02, + "Num Positive per mm^2": 523.34 + } +} \ No newline at end of file diff --git a/416/InvasionFront_CD8_block20_x3_y11_patient416_0.json b/416/InvasionFront_CD8_block20_x3_y11_patient416_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5d646920ea0345a6dae935a0be9e23e1ebeb8e0c --- /dev/null +++ b/416/InvasionFront_CD8_block20_x3_y11_patient416_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12343.5, + "Centroid Y µm": 27435.5, + "Num Detections": 13974, + "Num Negative": 13833, + "Num Positive": 141, + "Positive %": 1.009, + "Num Positive per mm^2": 85.89 + } +} \ No newline at end of file diff --git a/416/InvasionFront_CD8_block20_x4_y11_patient416_1.json b/416/InvasionFront_CD8_block20_x4_y11_patient416_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b59b2f589cc7b730278e7c6d1bd83456f608e311 --- /dev/null +++ b/416/InvasionFront_CD8_block20_x4_y11_patient416_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14792.2, + "Centroid Y µm": 27335.5, + "Num Detections": 18370, + "Num Negative": 18143, + "Num Positive": 227, + "Positive %": 1.236, + "Num Positive per mm^2": 108.78 + } +} \ No newline at end of file diff --git a/416/TumorCenter_CD3_block20_x3_y11_patient416_0.json b/416/TumorCenter_CD3_block20_x3_y11_patient416_0.json new file mode 100644 index 0000000000000000000000000000000000000000..af84e19a3d04bdac0e6eb34ead83a3487a3b4f62 --- /dev/null +++ b/416/TumorCenter_CD3_block20_x3_y11_patient416_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11152.5, + "Centroid Y µm": 26317.7, + "Num Detections": 4501, + "Num Negative": 4311, + "Num Positive": 190, + "Positive %": 4.221, + "Num Positive per mm^2": 98.55 + } +} \ No newline at end of file diff --git a/416/TumorCenter_CD3_block20_x4_y11_patient416_1.json b/416/TumorCenter_CD3_block20_x4_y11_patient416_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0e0c0b28b5debae45bb3894f1f886584de81d37c --- /dev/null +++ b/416/TumorCenter_CD3_block20_x4_y11_patient416_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13614.2, + "Centroid Y µm": 26434.7, + "Num Detections": 17507, + "Num Negative": 16981, + "Num Positive": 526, + "Positive %": 3.005, + "Num Positive per mm^2": 257.64 + } +} \ No newline at end of file diff --git a/416/TumorCenter_CD8_block20_x3_y11_patient416_0.json b/416/TumorCenter_CD8_block20_x3_y11_patient416_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b33f00498b3770993650469724164cce8226de7c --- /dev/null +++ b/416/TumorCenter_CD8_block20_x3_y11_patient416_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11394.0, + "Centroid Y µm": 27635.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/416/TumorCenter_CD8_block20_x4_y11_patient416_1.json b/416/TumorCenter_CD8_block20_x4_y11_patient416_1.json new file mode 100644 index 0000000000000000000000000000000000000000..246981e46e55828e1e231fc1ff27d10ef1a7ef06 --- /dev/null +++ b/416/TumorCenter_CD8_block20_x4_y11_patient416_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13892.6, + "Centroid Y µm": 27535.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/416/history_text.txt b/416/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..0434298881f03ac218fd451afec61bbc3db13914 --- /dev/null +++ b/416/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma of the right glottis. \ No newline at end of file diff --git a/416/icd_codes.txt b/416/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f6d450b7e8595ab340bbaac1ff4d4b1e721838a --- /dev/null +++ b/416/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] \ No newline at end of file diff --git a/416/ops_codes.txt b/416/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..4e2fd74e41cfd4b5f8d3947987655bbdc57e77db --- /dev/null +++ b/416/ops_codes.txt @@ -0,0 +1 @@ +Endoskopische Laserresektion Larynxgewebe[5-302.5 ] Andere partielle Laryngektomie: Chordektomie, endolaryngeal[5-302.1 ] \ No newline at end of file diff --git a/416/patient_clinical_data.json b/416/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..810884de168b822ae2b21ae3940847d79726cf14 --- /dev/null +++ b/416/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 74, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/416/patient_pathological_data.json b/416/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b7cd15934579c8f2a7740e0838bf2e53886cd67a --- /dev/null +++ b/416/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "416", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.5 +} \ No newline at end of file diff --git a/416/surgery_description.txt b/416/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..07afbe82415bdc2105adf22f707c2eff925407f4 --- /dev/null +++ b/416/surgery_description.txt @@ -0,0 +1 @@ +Endoscopic laser resection, Chordectomy, endolaryngeal diff --git a/416/surgery_report.txt b/416/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..dc03ecda3c7257b496be1898d4d4f871be74636f --- /dev/null +++ b/416/surgery_report.txt @@ -0,0 +1 @@ +Detailed consultation with the anesthesia department. Intubation with a laser tube. Adjustment of the larynx with a small water tube and repeated assessment of the tumor under microscopic control. The tumor does not quite reach the anterior commissure and fills the entire right vocal fold, which is clearly thickened. Using the CO2 laser at 3 W, the tumor is now carefully cut around under microscopic control. Clinically, macroscopically and microscopically in healthy tissue. The tumor is successfully removed laterally, caudally, posteriorly and anteriorly in toto. Repeated hemostasis with monopolar coagulation and Otriven swabs. No more bleeding. Removal of circular margin samples. Sending the material for frozen section. These are all found to be tumor-free. Repeated check of the situs. No more bleeding. Removal of the small drainage tube. Detailed consultation with the anesthetist. Wait for the definitive histology. Plan control endoscopy in 3 months. \ No newline at end of file diff --git a/417/InvasionFront_CD3_block9_x1_y7_patient417_0.json b/417/InvasionFront_CD3_block9_x1_y7_patient417_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f508813edd70c0507a838247823ea86babb94792 --- /dev/null +++ b/417/InvasionFront_CD3_block9_x1_y7_patient417_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4922.4, + "Centroid Y µm": 17490.7, + "Num Detections": 25194, + "Num Negative": 25127, + "Num Positive": 67, + "Positive %": 0.2659, + "Num Positive per mm^2": 28.35 + } +} \ No newline at end of file diff --git a/417/InvasionFront_CD3_block9_x2_y7_patient417_1.json b/417/InvasionFront_CD3_block9_x2_y7_patient417_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e2492eb1883077d5a06db3007649e914b79b914 --- /dev/null +++ b/417/InvasionFront_CD3_block9_x2_y7_patient417_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7621.0, + "Centroid Y µm": 17890.5, + "Num Detections": 7011, + "Num Negative": 6992, + "Num Positive": 19, + "Positive %": 0.271, + "Num Positive per mm^2": 24.14 + } +} \ No newline at end of file diff --git a/417/InvasionFront_CD8_block9_x1_y7_patient417_0.json b/417/InvasionFront_CD8_block9_x1_y7_patient417_0.json new file mode 100644 index 0000000000000000000000000000000000000000..bd4a520d754fa92bf768d748c849876e8517460a --- /dev/null +++ b/417/InvasionFront_CD8_block9_x1_y7_patient417_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4997.4, + "Centroid Y µm": 21388.7, + "Num Detections": 20480, + "Num Negative": 20417, + "Num Positive": 63, + "Positive %": 0.3076, + "Num Positive per mm^2": 32.02 + } +} \ No newline at end of file diff --git a/417/InvasionFront_CD8_block9_x2_y7_patient417_1.json b/417/InvasionFront_CD8_block9_x2_y7_patient417_1.json new file mode 100644 index 0000000000000000000000000000000000000000..afda848524233f3cdb1dbf0ea3ca03a09132e664 --- /dev/null +++ b/417/InvasionFront_CD8_block9_x2_y7_patient417_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7589.3, + "Centroid Y µm": 21493.8, + "Num Detections": 3932, + "Num Negative": 3899, + "Num Positive": 33, + "Positive %": 0.8393, + "Num Positive per mm^2": 66.48 + } +} \ No newline at end of file diff --git a/417/TumorCenter_CD3_block9_x1_y7_patient417_0.json b/417/TumorCenter_CD3_block9_x1_y7_patient417_0.json new file mode 100644 index 0000000000000000000000000000000000000000..15191043d5df3e038ecb23d9d98a968bface6755 --- /dev/null +++ b/417/TumorCenter_CD3_block9_x1_y7_patient417_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4022.9, + "Centroid Y µm": 23087.8, + "Num Detections": 28608, + "Num Negative": 28347, + "Num Positive": 261, + "Positive %": 0.9123, + "Num Positive per mm^2": 97.45 + } +} \ No newline at end of file diff --git a/417/TumorCenter_CD3_block9_x2_y7_patient417_1.json b/417/TumorCenter_CD3_block9_x2_y7_patient417_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cb1dbd9cd15b8dc179d0e7dab41790865a8d31b4 --- /dev/null +++ b/417/TumorCenter_CD3_block9_x2_y7_patient417_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6546.5, + "Centroid Y µm": 23012.8, + "Num Detections": 27038, + "Num Negative": 26359, + "Num Positive": 679, + "Positive %": 2.511, + "Num Positive per mm^2": 271.37 + } +} \ No newline at end of file diff --git a/417/TumorCenter_CD8_block9_x1_y7_patient417_0.json b/417/TumorCenter_CD8_block9_x1_y7_patient417_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08dcec148c2c0681865e8a0dab18da8f597eb364 --- /dev/null +++ b/417/TumorCenter_CD8_block9_x1_y7_patient417_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 18915.0, + "Num Detections": 26528, + "Num Negative": 26437, + "Num Positive": 91, + "Positive %": 0.343, + "Num Positive per mm^2": 34.68 + } +} \ No newline at end of file diff --git a/417/TumorCenter_CD8_block9_x2_y7_patient417_1.json b/417/TumorCenter_CD8_block9_x2_y7_patient417_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb34b2792a53dd9e2f2d99135d0ddb8d409bb7fb --- /dev/null +++ b/417/TumorCenter_CD8_block9_x2_y7_patient417_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6575.4, + "Centroid Y µm": 18726.0, + "Num Detections": 24492, + "Num Negative": 24427, + "Num Positive": 65, + "Positive %": 0.2654, + "Num Positive per mm^2": 27.67 + } +} \ No newline at end of file diff --git a/417/history_text.txt b/417/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/417/icd_codes.txt b/417/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b4da34c6138b78c8c6e57494021fa524c9c39d49 --- /dev/null +++ b/417/icd_codes.txt @@ -0,0 +1 @@ +Neubildung bösartig weicher Gaumen[C05.1 ] \ No newline at end of file diff --git a/417/ops_codes.txt b/417/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1ca65e5567936aec1692402194897ec838f5c3d --- /dev/null +++ b/417/ops_codes.txt @@ -0,0 +1 @@ +Diagnostische Tracheobronchoskopie mit starrem Instrument[1-620.1 ] Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Pharyngoskopie: Indirekt[1-611.1 ] Diagnostische Rhinoskopie[1-612 ] Diagnostische Ösophagoskopie: Mit flexiblem Instrument[1-630.0 ] Gaumenbogenkarzinom-Resektion[5-272.1 ] \ No newline at end of file diff --git a/417/patient_clinical_data.json b/417/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bf1784a9790109e7863481bd7568b41612d6ba15 --- /dev/null +++ b/417/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2008, + "age_at_initial_diagnosis": 54, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 11, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/417/patient_pathological_data.json b/417/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a9cd34f49c88d5cb1e10a69a7560148728fcbea9 --- /dev/null +++ b/417/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "417", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 41, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/417/surgery_description.txt b/417/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..481080905121ee1e21a2d945bf3806f7d54b557f --- /dev/null +++ b/417/surgery_description.txt @@ -0,0 +1 @@ +Resection of Palatal Arch carcinoma, Panendoscopy diff --git a/417/surgery_report.txt b/417/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a22cb0ee407f9f08bb4d2d674404e11852a5c464 --- /dev/null +++ b/417/surgery_report.txt @@ -0,0 +1 @@ +Tracheoscopy: There is no irritation from the level of the vocal folds to the carina. Laryngoscopy/hypopharyngoscopy: Base of the tongue, tonsillar lobes, all hypopharyngeal walls and larynx show smooth mucous membranes. No evidence of exophytic tumor growth. Esophagoscopy: Easy advancement of the esophagoscope. The esophagus is examined under retraction. Smooth conditions here too. Epipharyngoscopy/tumor resection: insertion of the tonsil plug. Velotractio. No evidence of tumor growth in the nasopharynx. Then inspection of the palatal arches. The left paramedian shows an ulcer of approx. 1 cm in size on the anterior palatal arch, partly with exophytic tumor parts and surrounding marginal wall. Incision of the tumor with macroscopically sufficient safety distance. Mark the specimen with a long suture = cranial and a short suture = medial. Careful hemostasis with bipolar coagulation. Dry conditions at the end of the operation. \ No newline at end of file diff --git a/418/InvasionFront_CD3_block14_x5_y7_patient418_0.json b/418/InvasionFront_CD3_block14_x5_y7_patient418_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d352a6523fa385fcd9722978d81d23a6161cc5f2 --- /dev/null +++ b/418/InvasionFront_CD3_block14_x5_y7_patient418_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16866.1, + "Centroid Y µm": 21538.6, + "Num Detections": 21603, + "Num Negative": 20894, + "Num Positive": 709, + "Positive %": 3.282, + "Num Positive per mm^2": 290.68 + } +} \ No newline at end of file diff --git a/418/InvasionFront_CD3_block14_x6_y7_patient418_1.json b/418/InvasionFront_CD3_block14_x6_y7_patient418_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a892ca997072dac345f6c19b0940f2f9ab25fe40 --- /dev/null +++ b/418/InvasionFront_CD3_block14_x6_y7_patient418_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19464.7, + "Centroid Y µm": 21613.6, + "Num Detections": 22857, + "Num Negative": 21858, + "Num Positive": 999, + "Positive %": 4.371, + "Num Positive per mm^2": 401.78 + } +} \ No newline at end of file diff --git a/418/InvasionFront_CD8_block14_x5_y7_patient418_0.json b/418/InvasionFront_CD8_block14_x5_y7_patient418_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2e8cd59ba568eb583ab7344085b252d95bd215a5 --- /dev/null +++ b/418/InvasionFront_CD8_block14_x5_y7_patient418_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16866.1, + "Centroid Y µm": 17215.9, + "Num Detections": 19561, + "Num Negative": 18965, + "Num Positive": 596, + "Positive %": 3.047, + "Num Positive per mm^2": 251.39 + } +} \ No newline at end of file diff --git a/418/InvasionFront_CD8_block14_x6_y7_patient418_1.json b/418/InvasionFront_CD8_block14_x6_y7_patient418_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6c80dfe0e8727debc072c1ebd60b4399508bfe1e --- /dev/null +++ b/418/InvasionFront_CD8_block14_x6_y7_patient418_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19439.7, + "Centroid Y µm": 17115.9, + "Num Detections": 21966, + "Num Negative": 20366, + "Num Positive": 1600, + "Positive %": 7.284, + "Num Positive per mm^2": 652.61 + } +} \ No newline at end of file diff --git a/418/TumorCenter_CD3_block14_x5_y7_patient418_0.json b/418/TumorCenter_CD3_block14_x5_y7_patient418_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a5ff046c9c9eb77dacd31a95afd238d1f64f8d65 --- /dev/null +++ b/418/TumorCenter_CD3_block14_x5_y7_patient418_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16441.3, + "Centroid Y µm": 18115.4, + "Num Detections": 19332, + "Num Negative": 18382, + "Num Positive": 950, + "Positive %": 4.914, + "Num Positive per mm^2": 392.47 + } +} \ No newline at end of file diff --git a/418/TumorCenter_CD3_block14_x6_y7_patient418_1.json b/418/TumorCenter_CD3_block14_x6_y7_patient418_1.json new file mode 100644 index 0000000000000000000000000000000000000000..64976d8008ffe82a9422c8fadee64e4e73ee757e --- /dev/null +++ b/418/TumorCenter_CD3_block14_x6_y7_patient418_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18965.0, + "Centroid Y µm": 18265.3, + "Num Detections": 18419, + "Num Negative": 17692, + "Num Positive": 727, + "Positive %": 3.947, + "Num Positive per mm^2": 308.14 + } +} \ No newline at end of file diff --git a/418/TumorCenter_CD8_block14_x5_y7_patient418_0.json b/418/TumorCenter_CD8_block14_x5_y7_patient418_0.json new file mode 100644 index 0000000000000000000000000000000000000000..424a100b6be698fcac4165d5c025f5d690eb7395 --- /dev/null +++ b/418/TumorCenter_CD8_block14_x5_y7_patient418_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15716.7, + "Centroid Y µm": 18115.4, + "Num Detections": 18543, + "Num Negative": 18009, + "Num Positive": 534, + "Positive %": 2.88, + "Num Positive per mm^2": 233.49 + } +} \ No newline at end of file diff --git a/418/TumorCenter_CD8_block14_x6_y7_patient418_1.json b/418/TumorCenter_CD8_block14_x6_y7_patient418_1.json new file mode 100644 index 0000000000000000000000000000000000000000..cad1c0107021521252c3e0492b24d4098ba87c0a --- /dev/null +++ b/418/TumorCenter_CD8_block14_x6_y7_patient418_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18240.3, + "Centroid Y µm": 18140.4, + "Num Detections": 17724, + "Num Negative": 17349, + "Num Positive": 375, + "Positive %": 2.116, + "Num Positive per mm^2": 160.74 + } +} \ No newline at end of file diff --git a/418/history_text.txt b/418/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..5073ad276562657aa9ae1fc9ebdcfa5b5767fd53 --- /dev/null +++ b/418/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed tongue margin carcinoma on the left side. There is now an indication for transoral resection. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/418/icd_codes.txt b/418/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6a646ec8e518182e3afc216f4896a1f097fb050e --- /dev/null +++ b/418/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung des Zungenrandes[C02.1 L] Unsichere Neubildung der Zungenwurzel[D37.0 R] \ No newline at end of file diff --git a/418/ops_codes.txt b/418/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f073a1130becfa9fb802fc48b25f5648a7cd2a24 --- /dev/null +++ b/418/ops_codes.txt @@ -0,0 +1 @@ +Intraoperative diagnostische Tracheoskopie[1-690.1 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Biopsie an der Zunge ohne Inzision[1-420.1 ] Sonstige partielle Glossektomie sonstige[5-251.xx ] \ No newline at end of file diff --git a/418/patient_clinical_data.json b/418/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..014791b91f5e9f9d88f682c6a5fab52ec8213d7d --- /dev/null +++ b/418/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 69, + "sex": "female", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 25, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin + cetuximab", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/418/patient_pathological_data.json b/418/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..0fee3b939e96f77415e6ffa90bc09d0f158f7b1b --- /dev/null +++ b/418/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "418", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 12, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/418/surgery_description.txt b/418/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..1ad4850b811f9c06baf5fc9c3d4a3c50ae5aace1 --- /dev/null +++ b/418/surgery_description.txt @@ -0,0 +1 @@ +Partial glossectomy and Panendoscopy diff --git a/418/surgery_report.txt b/418/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..780051feb13b9e1df747c259d3c553ed8ea8c5a0 --- /dev/null +++ b/418/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia. Transition to rigid tracheoscopy. Adjustment of the glottis and passing through it using the 0° optics. The mucosal conditions are unremarkable on all sides up to the exit of the segmental bronchi. The patient is then intubated by the surgeon. Transition to esophagogastroscopy. Insertion of the flexible endoscope under visualization and constant air insufflation into the stomach. This reveals a typical gastric mucosal relief without irritation on all sides. Inversion and inspection of the gastroesophageal junction. This appears unremarkable. After desufflation, slow withdrawal of the endoscope with circular inspection of all sections of the esophagus. There is no evidence of a tumor here. Remove the flexible endoscope. Insertion of the mouth guard. Prior to this, the patient is positioned in head reclination. Enter with the size C small bore tube. Adjustment of the endolarynx. This appears unremarkable. Inspection of the hypopharynx on both sides. Here the piriform sinus is lined with smooth mucosa on all sides up to the tip and can be freely unfolded. Subsequent inspection of the oropharynx. A somewhat uneven mucosa can be seen in the area of the right-sided base of the tongue. This is also biopsied. Primarily no urgent malignant findings. Otherwise unremarkable mucosal conditions in the area of the oropharynx. Inspection of the edge of the tongue on the left side. This shows the partially ulcerated lesion described above in the area of the middle third of the tongue. Subsequent insertion of the Jennings mouth retractor. Snaring of the tongue. Marking of the planned resection margins using the electric needle. Circular cutting around the tumor while maintaining the necessary safety distance. The specimen is then sent in for definitive histology. Clinically macroscopically, this is an in sano resection. Only in the area of the posterior third of the resection does the mucosa still appear slightly leukoplakic. Therefore, a post-resection specimen is taken from the dorsum of the tongue to the dorsal third of the tongue and the floor of the mouth. This preparation is also thread-marked for definitive histology. Injection of carbostesin solution for postoperative analgesia. In addition, inverted suturing of the wound edges with PDS 4.0, resulting in complete readaptation of the tongue edges. Final inspection. If the wound bed is dry, the operation is completed without complications. Removal of the rein suture. Removal of the jenning. Final consultation with the anesthetist. Positioning of the patient. Completion of the operation without complications. \ No newline at end of file diff --git a/419/InvasionFront_CD3_block10_x3_y5_patient419_0.json b/419/InvasionFront_CD3_block10_x3_y5_patient419_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a4bdea12c9354791739a287d5743f9d520c7b252 --- /dev/null +++ b/419/InvasionFront_CD3_block10_x3_y5_patient419_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13392.9, + "Centroid Y µm": 17940.5, + "Num Detections": 21005, + "Num Negative": 20159, + "Num Positive": 846, + "Positive %": 4.028, + "Num Positive per mm^2": 365.2 + } +} \ No newline at end of file diff --git a/419/InvasionFront_CD3_block10_x4_y5_patient419_1.json b/419/InvasionFront_CD3_block10_x4_y5_patient419_1.json new file mode 100644 index 0000000000000000000000000000000000000000..fa0d41c080371e236e77f661654d9eb097f8da51 --- /dev/null +++ b/419/InvasionFront_CD3_block10_x4_y5_patient419_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16191.4, + "Centroid Y µm": 18065.4, + "Num Detections": 27171, + "Num Negative": 22547, + "Num Positive": 4624, + "Positive %": 17.02, + "Num Positive per mm^2": 1705.5 + } +} \ No newline at end of file diff --git a/419/InvasionFront_CD8_block10_x3_y5_patient419_0.json b/419/InvasionFront_CD8_block10_x3_y5_patient419_0.json new file mode 100644 index 0000000000000000000000000000000000000000..40b7b44232c84728f24d6c5c65f7a7f6484f5c6a --- /dev/null +++ b/419/InvasionFront_CD8_block10_x3_y5_patient419_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12568.3, + "Centroid Y µm": 18265.3, + "Num Detections": 21683, + "Num Negative": 21205, + "Num Positive": 478, + "Positive %": 2.204, + "Num Positive per mm^2": 204.45 + } +} \ No newline at end of file diff --git a/419/InvasionFront_CD8_block10_x4_y5_patient419_1.json b/419/InvasionFront_CD8_block10_x4_y5_patient419_1.json new file mode 100644 index 0000000000000000000000000000000000000000..59f5e916dea433aa4ea3160de0bf49436ba9ffa4 --- /dev/null +++ b/419/InvasionFront_CD8_block10_x4_y5_patient419_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15391.9, + "Centroid Y µm": 18215.4, + "Num Detections": 29399, + "Num Negative": 26508, + "Num Positive": 2891, + "Positive %": 9.834, + "Num Positive per mm^2": 1070.4 + } +} \ No newline at end of file diff --git a/419/TumorCenter_CD3_block10_x3_y5_patient419_0.json b/419/TumorCenter_CD3_block10_x3_y5_patient419_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f36b1247891c3791bbaddc7cbb9c6b7de46db099 --- /dev/null +++ b/419/TumorCenter_CD3_block10_x3_y5_patient419_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14142.5, + "Centroid Y µm": 12368.5, + "Num Detections": 15230, + "Num Negative": 13226, + "Num Positive": 2004, + "Positive %": 13.16, + "Num Positive per mm^2": 1087.5 + } +} \ No newline at end of file diff --git a/419/TumorCenter_CD3_block10_x4_y5_patient419_1.json b/419/TumorCenter_CD3_block10_x4_y5_patient419_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1336b13fb9044ffb2e9b864d1ab4e6608a56b6dc --- /dev/null +++ b/419/TumorCenter_CD3_block10_x4_y5_patient419_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16316.4, + "Centroid Y µm": 12418.4, + "Num Detections": 4575, + "Num Negative": 3560, + "Num Positive": 1015, + "Positive %": 22.19, + "Num Positive per mm^2": 1859.3 + } +} \ No newline at end of file diff --git a/419/TumorCenter_CD8_block10_x3_y5_patient419_0.json b/419/TumorCenter_CD8_block10_x3_y5_patient419_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cf04a27c2f31d62409503b246d6a62fc31264893 --- /dev/null +++ b/419/TumorCenter_CD8_block10_x3_y5_patient419_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11019.2, + "Centroid Y µm": 13093.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/419/TumorCenter_CD8_block10_x4_y5_patient419_1.json b/419/TumorCenter_CD8_block10_x4_y5_patient419_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de5c4b27b879834ada14450ac7bf9ad64119ae39 --- /dev/null +++ b/419/TumorCenter_CD8_block10_x4_y5_patient419_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 13018.1, + "Num Detections": 14518, + "Num Negative": 9917, + "Num Positive": 4601, + "Positive %": 31.69, + "Num Positive per mm^2": 2899.0 + } +} \ No newline at end of file diff --git a/419/history_text.txt b/419/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..39bec37e5363b6830106c882c19964d7c05cca3a --- /dev/null +++ b/419/history_text.txt @@ -0,0 +1 @@ +In the patient, an N3 metastasis of a moderately differentiated squamous cell carcinoma was histologically confirmed during a panendoscopy <2013>. No intraoperative evidence of primarius. In the staging performed, CT shows a left-sided tonsil asymmetry with increased enhancement in PET-CT in lateral comparison, otherwise no evidence of primarius or further metastasis. Extensive metastasis on CT with extension into the parapharyngeal space. Sonographic cN3 neck status. Now indication for completion of the CUP diagnosis and resection of the extensive metastasis on the left side. \ No newline at end of file diff --git a/419/icd_codes.txt b/419/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/419/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/419/ops_codes.txt b/419/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e7e493c185663b9177cbd0b4f56ff8c2e18b38e3 --- /dev/null +++ b/419/ops_codes.txt @@ -0,0 +1 @@ +Tonsillektomie radikal transoral[5-281.2 ] Biopsie an der Zunge ohne Inzision[1-420.1 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Perkutan-endoskopische Gastrostomie[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal erweitert 5 Regionen[5-403.31 L] \ No newline at end of file diff --git a/419/patient_clinical_data.json b/419/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3bb99ec121015de7e74e45c63108d67f6240fe5c --- /dev/null +++ b/419/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 61, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/419/patient_pathological_data.json b/419/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..1857f474181ccc1fc4c18ae791e6216dfb372aa1 --- /dev/null +++ b/419/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "419", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN3", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 6.0 +} \ No newline at end of file diff --git a/419/surgery_description.txt b/419/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c000950523a0bda33f73a4c8901fa5e1c2d50f70 --- /dev/null +++ b/419/surgery_description.txt @@ -0,0 +1 @@ +Tonsillectomy, Neck dissection, PEG placement diff --git a/419/surgery_report.txt b/419/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..a61361a7bddff2e13c9bf584a6c8f0f4dc50490d --- /dev/null +++ b/419/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesiology colleagues, the patient is first positioned and then the small water tube is inserted under dental protection. After inspection of the inconspicuous oral vestibule. The oral cavity is inconspicuous. In the area of the oropharynx, the tonsils are scarred and cryptic on both sides, slight asymmetry in favor of the left side, but no exophytic tumor. The base of the tongue is seen on the left side with questionable slight tissue plus, otherwise macroscopically not suspicious. The rest of the oropharynx is unremarkable and clear, as are the endolarynx and the hypopharynx, which is slightly edematous and cannot be fully adjusted due to the physiognomy, but is clear as far as can be assessed. Inconspicuous postcricoid region. Corresponding to the diagnostic imaging, a diagnostic tonsillectomy is now performed on the left side and, in the case of slightly raised findings in the area of the base of the tongue, a representative biopsy of the base of the tongue is taken. Tonsillectomy performed using the classic dissection technique. Significant scarring of the tonsil capsule, but rather no tumor growth, therefore initially no resection towards the parapharyngeal space due to the extensive metastasis. Protection of the parauvular mucosal triangle and the posterior palatal arch and removal of the tonsil in toto. Careful hemostasis. Inspection of the tonsil after removal reveals an exophytic change after opening in the area of the cranial tonsil pole or here in the area of the crypts, which is highly suspicious, so the specimen is thread-marked and sent for frozen section diagnostics. This confirms the clinical suspicion of a tonsillar carcinoma, CIS forming margins in the area of the cranial pole, otherwise an R0 situation at all levels. Therefore, complete resection of the cranial tonsil ........., partly with soft palate-parauvular tissue and upper part of the posterior palatal arch. Complete imaging margin specimen. In the frozen section diagnostics, this is again completely tumor-free, therefore safe R0 resection here. The sample taken from the base of the tongue was tumor-free. In the meantime, the PEG was inserted. This was done with the gastroscope under laryngoscopic control. Easy to see through to the stomach. This was inconspicuous and clear. With good diaphanoscopy, problem-free puncture of the stomach and insertion of the PEG tube using the usual thread pull-through method. On reflection, the esophagus is clear and unremarkable. We now turn to the neck dissection. A coarse, moderately displaceable mass measuring clinically approx. 8 x 8 cm with clear infiltration of the sternocleidomastoid muscle is seen. The skin incision is now made from the mastoid to the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Expose and cut through the platysma. This is clearly not infiltrated. Dissection of the platysma. Exposure of the sternocleidomastoid muscle in the caudal part. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. The cranial part of the sternocleidomastoid muscle is completely infiltrated up to just before the mastoid insertion. Ligation and removal of the external jugular vein and the auricular nerve. Separation of the sternocleidomastoid muscle at the level of the omohyoid muscle. Exposure and dissection of the internal jugular vein. Overall, significantly more difficult preparation conditions due to the patient's physiognomy. It can now be seen that the metastasis surrounds the cervical vascular sheath by approx. 180° and clearly extends to level V a. Here, subtotal infiltration of the cervical plexus, as well as infiltration of the phrenic nerve and the border cord. In addition, infiltration of the paravertebral musculature. En bloc resection here of the metastasis. Separation of the sternocleidomastoid muscle at the mastoid. Separation of the internal jugular vein. Anterior free dissection and preservation of the superior thyroid artery. The facial vein is removed during infiltration. Dissection of the caudal parotid pole. This works well. No infiltration here. There is now a circumscribed infiltration of the posterior digastric venter muscle. This is also generously resected. Infiltration of the barely visible hypoglossal nerve. Complete infiltration of the accessorius nerve. Now dissection directly onto the common carotid artery. Exposure and securing of the vagus nerve. Shortly after the exit of the superior thyroid artery, the external carotid artery is seen to be infiltrated. This is also removed. Removal of the infiltrated branch of the facial artery. Resection of the metastasis cranially up to the transverse process of the atlas and close to the spinal column, but here still covering the muscle layer. No tumor growth cranial to the digastric muscle, so that the metastasis can be removed in toto without opening the pharynx. Careful hemostasis. Evacuation of level V a and b remnants. Finally, no evidence of lymphatic leakage. Protection of the transverse cervical artery. Extensive wound irrigation with H2O2 and Ringer's solution and, if the wound is absolutely dry, insertion of two 10-gauge Redon drains if the wound area is extensive. Subsequent careful, two-layer wound closure. Final enoral inspection, in this case dry conditions. To further reduce the pharyngo-cervical fistula, the posterior and anterior palatal arch is adapted using 3-0 Vicryl mucosal sutures. Completion of the procedure with slim mucosa conditions. Conclusion: Intraoperatively histologically confirmed cT1 cN3 G2 R0 left tonsillar carcinoma. Please leave the Redon drains in place for at least 3 days due to the extensive wound cavity and plan adjuvant radiochemotherapy promptly. \ No newline at end of file diff --git a/420/InvasionFront_CD3_block9_x5_y11_patient420_0.json b/420/InvasionFront_CD3_block9_x5_y11_patient420_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8cbe552c014738f327e4f63171a4bbc1693ce68f --- /dev/null +++ b/420/InvasionFront_CD3_block9_x5_y11_patient420_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 29234.5, + "Num Detections": 21299, + "Num Negative": 19834, + "Num Positive": 1465, + "Positive %": 6.878, + "Num Positive per mm^2": 642.49 + } +} \ No newline at end of file diff --git a/420/InvasionFront_CD3_block9_x6_y11_patient420_1.json b/420/InvasionFront_CD3_block9_x6_y11_patient420_1.json new file mode 100644 index 0000000000000000000000000000000000000000..414870c44b8b3d8cfb2722149142af16b54a52ea --- /dev/null +++ b/420/InvasionFront_CD3_block9_x6_y11_patient420_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19114.9, + "Centroid Y µm": 29559.3, + "Num Detections": 28664, + "Num Negative": 26555, + "Num Positive": 2109, + "Positive %": 7.358, + "Num Positive per mm^2": 753.01 + } +} \ No newline at end of file diff --git a/420/InvasionFront_CD8_block9_x5_y11_patient420_0.json b/420/InvasionFront_CD8_block9_x5_y11_patient420_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c3f4e3bbd4b7b6f0cb6c7039dd66fb9630183df1 --- /dev/null +++ b/420/InvasionFront_CD8_block9_x5_y11_patient420_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16566.2, + "Centroid Y µm": 32707.7, + "Num Detections": 25619, + "Num Negative": 23808, + "Num Positive": 1811, + "Positive %": 7.069, + "Num Positive per mm^2": 819.25 + } +} \ No newline at end of file diff --git a/420/InvasionFront_CD8_block9_x6_y11_patient420_1.json b/420/InvasionFront_CD8_block9_x6_y11_patient420_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d0bf35d7e03f417f57301d25336b06b6ec2d519a --- /dev/null +++ b/420/InvasionFront_CD8_block9_x6_y11_patient420_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19239.8, + "Centroid Y µm": 33032.5, + "Num Detections": 28546, + "Num Negative": 21819, + "Num Positive": 6727, + "Positive %": 23.57, + "Num Positive per mm^2": 2440.1 + } +} \ No newline at end of file diff --git a/420/TumorCenter_CD3_block9_x5_y11_patient420_0.json b/420/TumorCenter_CD3_block9_x5_y11_patient420_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0e49e05a548fb402a2f0abab6cd160210401e4b0 --- /dev/null +++ b/420/TumorCenter_CD3_block9_x5_y11_patient420_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15916.6, + "Centroid Y µm": 33207.4, + "Num Detections": 22929, + "Num Negative": 13441, + "Num Positive": 9488, + "Positive %": 41.38, + "Num Positive per mm^2": 3595.6 + } +} \ No newline at end of file diff --git a/420/TumorCenter_CD3_block9_x6_y11_patient420_1.json b/420/TumorCenter_CD3_block9_x6_y11_patient420_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3c9203126b9645b90a83363409202a0124571d7f --- /dev/null +++ b/420/TumorCenter_CD3_block9_x6_y11_patient420_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18415.2, + "Centroid Y µm": 33282.4, + "Num Detections": 22460, + "Num Negative": 12890, + "Num Positive": 9570, + "Positive %": 42.61, + "Num Positive per mm^2": 3879.1 + } +} \ No newline at end of file diff --git a/420/TumorCenter_CD8_block9_x5_y11_patient420_0.json b/420/TumorCenter_CD8_block9_x5_y11_patient420_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2e2cc381857b263dd6815ac18f686b878f8d6151 --- /dev/null +++ b/420/TumorCenter_CD8_block9_x5_y11_patient420_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16823.2, + "Centroid Y µm": 28745.7, + "Num Detections": 21370, + "Num Negative": 12694, + "Num Positive": 8676, + "Positive %": 40.6, + "Num Positive per mm^2": 3437.8 + } +} \ No newline at end of file diff --git a/420/TumorCenter_CD8_block9_x6_y11_patient420_1.json b/420/TumorCenter_CD8_block9_x6_y11_patient420_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7e0e6821326b7771170164ba3ec552edb3340fc4 --- /dev/null +++ b/420/TumorCenter_CD8_block9_x6_y11_patient420_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19419.2, + "Centroid Y µm": 28719.4, + "Num Detections": 22972, + "Num Negative": 14862, + "Num Positive": 8110, + "Positive %": 35.3, + "Num Positive per mm^2": 3174.6 + } +} \ No newline at end of file diff --git a/420/history_text.txt b/420/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..c86845bc52bacdab0b8ff2a97bb4cd63df369d26 --- /dev/null +++ b/420/history_text.txt @@ -0,0 +1 @@ +A squamous cell carcinoma of the left base of the tongue was histologically confirmed in the patient. Therefore, the above-mentioned procedure is now being performed. \ No newline at end of file diff --git a/420/icd_codes.txt b/420/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8fee5f62048ff6bb507378ac92fc0824bb41b5a0 --- /dev/null +++ b/420/icd_codes.txt @@ -0,0 +1 @@ +Halslymphknotenmetastasen[C77.0 ] \ No newline at end of file diff --git a/420/ops_codes.txt b/420/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..6c19c2f57678e7bf79cf52df963efa39098db6d7 --- /dev/null +++ b/420/ops_codes.txt @@ -0,0 +1 @@ +Zungentumorexzision[5-250.2 ] Totale Laserresektion Zunge transoral sonstige[5-252.0x ] Anlegen einer PEG[5-431.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] \ No newline at end of file diff --git a/420/patient_clinical_data.json b/420/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..99cc4ed1c793934d7fa47e9f4f0cce2b43e1027b --- /dev/null +++ b/420/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 2, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/420/patient_pathological_data.json b/420/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..bcbaacf695085581604b6a4cc1b0000e7133478d --- /dev/null +++ b/420/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "420", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 20, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 2.0 +} \ No newline at end of file diff --git a/420/surgery_description.txt b/420/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e8efb3861be3087104898bd4078653912a0387f4 --- /dev/null +++ b/420/surgery_description.txt @@ -0,0 +1 @@ +Transoral Laser Resection, Neck dissection, PEG placement diff --git a/420/surgery_report.txt b/420/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..f3afb33f1051a58f1b61bb3434998f59f41fdbf3 --- /dev/null +++ b/420/surgery_report.txt @@ -0,0 +1 @@ +Detailed consultation with the anesthesiologist regarding the intraoperative procedure. Insertion of the small bore tube towards the base of the tongue. Identification of the biopsy site. A slightly exophytic, ulcerating tumor can be seen. This is now cut around clinically with the laser in the healthy area, starting from cranial to caudal, laterally and medially. Resection of part of the left tongue base up to the direction of the vallecula. There, the laser is deposited caudally and laterally. Finally, the tumor can be completely resected clinically in sano. Relatively little oozing. A smaller ectatic vein, which is not ......................, is additionally coagulated with the double spoon. Finally, take circular marginal samples and from the base of the tongue. These are all found to be tumor-free in the frozen section. Entering the stomach through the esophagus with the flexible esophagoscope. This is relatively easy. Good diaphanoscopy. Insertion of the PEG using the puncture method in the usual way. The puncture and the thread pull-through are successful. No further bleeding here. Intraoperative administration of Unacid perioperatively. Continue this for one day postoperatively. Repositioning of the patient for neck dissection: skin disinfection and sterile wound covering. Infiltration in the area of both sides of the neck on the front edge of the sternocleidomastoid muscle with Ultracaine. Start on the right side. Skin incision on the anterior edge of the sternocleidomastoid muscle. Exposure of the muscle. Very difficult dissection as bleeding always occurs. Exposure of the internal jugular vein, the facial vein, the posterior digastric venter muscle and the accessorius nerve. Displacement, neurolysis and re-embedding of the accessory nerve. Now dissection of the posterior triangle of the accessory nerve from cranial to caudal, sparing the accessory nerve. Dissection along the vein, after exposing the vagus nerve caudally and depositing in the area of the omohyoid muscle. Displacement, neurolysis and re-embedding of the vagus nerve. Some larger lymph nodes are conspicuous, but clinically no evidence of metastasis. Now visualization of the external and internal carotid arteries and the hypoglossal nerve. Displacement, neurolysis and re-embedding of the hypoglossal nerve. Dissection of the anterior neck preparation. Smaller veins repeatedly tear, even directly in the area of the internal jugular vein. This therefore has to be stitched twice. No more bleeding. Exposure of the hypoglossal nerve and the cervical vein, which is left in place. Removal of the capsule of the submandibular gland. Extensive hemostasis with H2O2 swabs and bipolar coagulation. No more bleeding. Insertion of a Redon drainage. Subcutaneous suture, skin suture, pressure bandage. Neck dissection of the left side: A lymph node metastasis was also clinically described in the preliminary findings. Skin incision on the front edge of the sternocleidomastoid muscle. Exposure of the muscle. Overall, recurrent bleeding and abundant vascularization. Difficult dissection conditions. After exposure of the muscle, exposure of the internal jugular vein. The accessorius nerve can be visualized in depth. Dissection of the common carotid artery, the vagus nerve and the internal and external carotid artery cranially and caudally. Displacement, neurolysis and re-embedding of the vagus nerve. Exposure of the digastric venter posterior muscle and dissection of the accessorius triangle. A large cystic lymph node metastasis can be seen here, starting directly under the accessorius nerve. Further lymph nodes are also removed from the accessorius triangle. Dissection is performed along the vein and vagus nerve as well as the common carotid artery from cranial to caudal, down to below the omohyoid muscle. The caudal edge of the sedimentation is stitched several times with Vicryl sutures to prevent a fistula. Now further dissection of the jugular vein anteriorly. Exposure of the hypoglossal nerve. Displacement, neurolysis and re-embedding of the hypoglossal nerve. Dissection of the anterior part of the neck, removal of the capsule of the submandibular gland and dissection from cranial to caudal. This results in a complete neck dissection. No bleeding. Irrigation with H2O2 and Ringer's solution. Minor oozing bleeding is stopped with bipolar coagulation. Insertion of a Redon drain. Subcutaneous suture, skin suture and pressure bandage. Another check of the primary resection with the small water tube: there is no major bleeding here. No swelling either. It is therefore decided not to tracheotomize the patient in the first instance. The patient is extubated and transferred to the intensive care unit for monitoring. Detailed consultation with the anesthesia department regarding the further procedure. Please note: Further perioperative administration of Unacid. \ No newline at end of file diff --git a/421/InvasionFront_CD3_block14_x3_y2_patient421_0.json b/421/InvasionFront_CD3_block14_x3_y2_patient421_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cf3c1588871a5d0b40863912e521187dcd665334 --- /dev/null +++ b/421/InvasionFront_CD3_block14_x3_y2_patient421_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12368.5, + "Centroid Y µm": 8720.4, + "Num Detections": 19184, + "Num Negative": 18781, + "Num Positive": 403, + "Positive %": 2.101, + "Num Positive per mm^2": 167.23 + } +} \ No newline at end of file diff --git a/421/InvasionFront_CD3_block14_x4_y2_patient421_1.json b/421/InvasionFront_CD3_block14_x4_y2_patient421_1.json new file mode 100644 index 0000000000000000000000000000000000000000..82bb7922f128dd9df1d9d5ee631fdbd712c6cab8 --- /dev/null +++ b/421/InvasionFront_CD3_block14_x4_y2_patient421_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14967.1, + "Centroid Y µm": 8745.4, + "Num Detections": 16950, + "Num Negative": 15946, + "Num Positive": 1004, + "Positive %": 5.923, + "Num Positive per mm^2": 434.1 + } +} \ No newline at end of file diff --git a/421/InvasionFront_CD8_block14_x3_y2_patient421_0.json b/421/InvasionFront_CD8_block14_x3_y2_patient421_0.json new file mode 100644 index 0000000000000000000000000000000000000000..da6f8170b8c64634aa32676c4c76e2769b3cbb2d --- /dev/null +++ b/421/InvasionFront_CD8_block14_x3_y2_patient421_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12093.6, + "Centroid Y µm": 4972.4, + "Num Detections": 19356, + "Num Negative": 19059, + "Num Positive": 297, + "Positive %": 1.534, + "Num Positive per mm^2": 127.05 + } +} \ No newline at end of file diff --git a/421/InvasionFront_CD8_block14_x4_y2_patient421_1.json b/421/InvasionFront_CD8_block14_x4_y2_patient421_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3761b209376df03b524ba98ce1b72d1f98a1f7a5 --- /dev/null +++ b/421/InvasionFront_CD8_block14_x4_y2_patient421_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14667.2, + "Centroid Y µm": 4897.4, + "Num Detections": 16310, + "Num Negative": 15530, + "Num Positive": 780, + "Positive %": 4.782, + "Num Positive per mm^2": 366.81 + } +} \ No newline at end of file diff --git a/421/TumorCenter_CD3_block14_x3_y2_patient421_0.json b/421/TumorCenter_CD3_block14_x3_y2_patient421_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c34c5c535fda12f39f11593f8c8e91b3fbef7e9 --- /dev/null +++ b/421/TumorCenter_CD3_block14_x3_y2_patient421_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12343.5, + "Centroid Y µm": 5347.2, + "Num Detections": 15508, + "Num Negative": 15106, + "Num Positive": 402, + "Positive %": 2.592, + "Num Positive per mm^2": 193.93 + } +} \ No newline at end of file diff --git a/421/TumorCenter_CD3_block14_x4_y2_patient421_1.json b/421/TumorCenter_CD3_block14_x4_y2_patient421_1.json new file mode 100644 index 0000000000000000000000000000000000000000..eafbe9c6a3a70f5c38ef5a5b845414723e654ce9 --- /dev/null +++ b/421/TumorCenter_CD3_block14_x4_y2_patient421_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 5547.1, + "Num Detections": 15798, + "Num Negative": 14896, + "Num Positive": 902, + "Positive %": 5.71, + "Num Positive per mm^2": 427.03 + } +} \ No newline at end of file diff --git a/421/TumorCenter_CD8_block14_x3_y2_patient421_0.json b/421/TumorCenter_CD8_block14_x3_y2_patient421_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2ac7e5f05d46728f1c22f05fc34cd306053bb968 --- /dev/null +++ b/421/TumorCenter_CD8_block14_x3_y2_patient421_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10944.2, + "Centroid Y µm": 5697.0, + "Num Detections": 16357, + "Num Negative": 16078, + "Num Positive": 279, + "Positive %": 1.706, + "Num Positive per mm^2": 135.01 + } +} \ No newline at end of file diff --git a/421/TumorCenter_CD8_block14_x4_y2_patient421_1.json b/421/TumorCenter_CD8_block14_x4_y2_patient421_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b1ebc8f8682a7f94f949fefb4f48489998c30b37 --- /dev/null +++ b/421/TumorCenter_CD8_block14_x4_y2_patient421_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13417.9, + "Centroid Y µm": 5771.9, + "Num Detections": 16293, + "Num Negative": 15558, + "Num Positive": 735, + "Positive %": 4.511, + "Num Positive per mm^2": 360.09 + } +} \ No newline at end of file diff --git a/421/history_text.txt b/421/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/421/icd_codes.txt b/421/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..59dcd6118ae784d1f8dd37e959c11012f0af829e --- /dev/null +++ b/421/icd_codes.txt @@ -0,0 +1 @@ +Zungentumor[D37.0 B] \ No newline at end of file diff --git a/421/ops_codes.txt b/421/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b054e9c4c2f172e719f73e9806b9e175a15ccb4b --- /dev/null +++ b/421/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Glossektomie sonstige[5-251.xx ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Sonstige perkutan-endoskopisch Gastrostomie (PEG)[5-431.2x ] \ No newline at end of file diff --git a/421/patient_clinical_data.json b/421/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d12dff3a5402864f031019b7f71c4ffb95b7864f --- /dev/null +++ b/421/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 53, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 12, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "brachytherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/421/patient_pathological_data.json b/421/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3cf9f1a7b8105eab6176adba9f9fa432acb8e00b --- /dev/null +++ b/421/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "421", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 13.0 +} \ No newline at end of file diff --git a/421/surgery_description.txt b/421/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..f2c3fe9f3b2a0204a79ac00c0b6b66eec24410c0 --- /dev/null +++ b/421/surgery_description.txt @@ -0,0 +1 @@ +Transoral Tumor Resection, PEG placement diff --git a/421/surgery_report.txt b/421/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..25fe9efc76e54a3da2dcc69edc985b17a3e5fa5c --- /dev/null +++ b/421/surgery_report.txt @@ -0,0 +1 @@ +PEG insertion: Entering the oesophagus with the flexible gastro-oesophagoscope, careful pre-scanning into the stomach. Air insufflation and identification of the anterior wall of the stomach. Perform a positive diaphanoscopy and then place the PEG tube in the area of the lateral canal in the usual manner using the thread pull-through method. Aspiration of air and subtle retraction of the endoscope with constant air insufflation. Neck dissection on the right: Start with neck dissection on the right side using a skin incision in the area of the old scar. Separation of the cutaneous-subcutaneous tissue and identification of the platysma. Overall, extremely scarred conditions are seen here following neck dissection and radiotherapy. In consultation with , it was decided not to proceed with the neck dissection. One reason is the current ycN0 neck status, the scarred conditions and, in particular, a possible secondary microvascular defect reconstruction of the tongue. Therefore, no further action is taken and the wound is closed again. After appropriate preparation, first insert the retractors and dislodge the tongue at the fixation suture. Then look at the tumor located medially in the posterior third, which extends a little further to the right than to the opposite side by palpation. Start resection at the anterior left margin. Here, the tumor is successively removed through the healthy musculature at an appropriate safety distance using the monopolar caustic technique. First, resection is performed on the left edge of the tumor in order to preserve the lingual artery, which is ultimately successful. The tumor is then successively removed from the left side through the muscles of the inner tongue. A sufficient safety margin can also be maintained in the area of the base of the tongue. The resection is somewhat more extensive on the right side, but a narrow strip of tissue remains in the area of the base of the tongue. Careful hemostasis by bipolar coagulation. On inspection of the resectate, the left anterior tumor resection margin is slightly less distant at the same side as the tumor. Therefore, a resection is performed on the tongue. Subsequently, marginal samples are taken from the entire circumference at the base of the tumor for a frozen section histological examination. These all proved to be tumor-free, so that an R0 resection can be assumed. Although the subsequent defect is extensive, it does not infiltrate particularly deeply, largely preserving the base of the tongue, so that no construction is necessary. Neck dissection can also be dispensed with in the case of cN0 status and previous neck dissection on both sides. Removal of the instruments without tooth damage and transfer of the patient to anesthesia. Conclusion: Transoral tumor resection of the median-dorsal tongue tumor. Intraoperative rapid section histologic R0 resection. No neck dissection in the case of previous neck dissection due to the nasopharyngeal carcinoma and primary reconstruction due to the configuration of the defect \ No newline at end of file diff --git a/422/InvasionFront_CD3_block6_x1_y3_patient422_0.json b/422/InvasionFront_CD3_block6_x1_y3_patient422_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ab846eb5c82d11c46f1a04c894257c47e5d7f34e --- /dev/null +++ b/422/InvasionFront_CD3_block6_x1_y3_patient422_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4911.4, + "Centroid Y µm": 7744.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/422/InvasionFront_CD3_block6_x2_y3_patient422_1.json b/422/InvasionFront_CD3_block6_x2_y3_patient422_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b3cb7dfa8168773c17208bcd218529ae35f17de4 --- /dev/null +++ b/422/InvasionFront_CD3_block6_x2_y3_patient422_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7800.5, + "Centroid Y µm": 7662.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/422/InvasionFront_CD8_block6_x1_y1_patient422_0.json b/422/InvasionFront_CD8_block6_x1_y1_patient422_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3620c4daa7020841d7e629faa2fe23eab0336beb --- /dev/null +++ b/422/InvasionFront_CD8_block6_x1_y1_patient422_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5647.0, + "Centroid Y µm": 1949.0, + "Num Detections": 18733, + "Num Negative": 18504, + "Num Positive": 229, + "Positive %": 1.222, + "Num Positive per mm^2": 104.38 + } +} \ No newline at end of file diff --git a/422/InvasionFront_CD8_block6_x2_y1_patient422_1.json b/422/InvasionFront_CD8_block6_x2_y1_patient422_1.json new file mode 100644 index 0000000000000000000000000000000000000000..762f3fb132c7cecbccf27cfec8c9836351feddd5 --- /dev/null +++ b/422/InvasionFront_CD8_block6_x2_y1_patient422_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8020.8, + "Centroid Y µm": 2048.9, + "Num Detections": 19193, + "Num Negative": 18910, + "Num Positive": 283, + "Positive %": 1.474, + "Num Positive per mm^2": 122.9 + } +} \ No newline at end of file diff --git a/422/TumorCenter_CD3_block6_x1_y1_patient422_0.json b/422/TumorCenter_CD3_block6_x1_y1_patient422_0.json new file mode 100644 index 0000000000000000000000000000000000000000..03d94cf09cc9b2201a24e29683d9832e41444be1 --- /dev/null +++ b/422/TumorCenter_CD3_block6_x1_y1_patient422_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3872.9, + "Centroid Y µm": 2873.5, + "Num Detections": 18159, + "Num Negative": 17024, + "Num Positive": 1135, + "Positive %": 6.25, + "Num Positive per mm^2": 524.69 + } +} \ No newline at end of file diff --git a/422/TumorCenter_CD3_block6_x2_y1_patient422_1.json b/422/TumorCenter_CD3_block6_x2_y1_patient422_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5ed3192cdee820380895c9298479f47a29efa4dc --- /dev/null +++ b/422/TumorCenter_CD3_block6_x2_y1_patient422_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6346.6, + "Centroid Y µm": 2748.5, + "Num Detections": 21040, + "Num Negative": 20269, + "Num Positive": 771, + "Positive %": 3.664, + "Num Positive per mm^2": 335.23 + } +} \ No newline at end of file diff --git a/422/TumorCenter_CD8_block6_x1_y1_patient422_0.json b/422/TumorCenter_CD8_block6_x1_y1_patient422_0.json new file mode 100644 index 0000000000000000000000000000000000000000..eacba85d31f01bb6d9cba4984a4368bc2ee69250 --- /dev/null +++ b/422/TumorCenter_CD8_block6_x1_y1_patient422_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 3048.4, + "Num Detections": 18799, + "Num Negative": 18507, + "Num Positive": 292, + "Positive %": 1.553, + "Num Positive per mm^2": 131.58 + } +} \ No newline at end of file diff --git a/422/TumorCenter_CD8_block6_x2_y1_patient422_1.json b/422/TumorCenter_CD8_block6_x2_y1_patient422_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2e27e66f6a5349d540d04516bf110125e226abc1 --- /dev/null +++ b/422/TumorCenter_CD8_block6_x2_y1_patient422_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 3048.4, + "Num Detections": 21077, + "Num Negative": 20897, + "Num Positive": 180, + "Positive %": 0.854, + "Num Positive per mm^2": 79.65 + } +} \ No newline at end of file diff --git a/422/history_text.txt b/422/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..10aab6bcdfc524eda201eebebfe9f507c54c9d47 --- /dev/null +++ b/422/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed squamous cell carcinoma in the area of the hard and soft palate and upper tonsillar lobe. There is a tumor that covers the entire palatal arch area from the upper tonsillar lobe on the right to the left side. Growth also on the back. No growth into the tube. However, growth also in the direction of the hard palate. Overall flap coverage indicated. Radialis flap not possible for vascular reasons, as Allen test not sufficient on both sides and other diagnostics likewise. Upper arm flap and other usual flap plasty not possible due to the required pedicle length. It was therefore decided to cover the defect with a latissimus dorsi flap together with the maxillofacial surgeon. \ No newline at end of file diff --git a/422/icd_codes.txt b/422/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..9d70edde74499673d3b91ee7519044267c0ca1e8 --- /dev/null +++ b/422/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Weicher Gaumen[C05.1 ] Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 B] \ No newline at end of file diff --git a/422/ops_codes.txt b/422/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c3dae242c5e55c07490591eb96e6a0f9152e2dc8 --- /dev/null +++ b/422/ops_codes.txt @@ -0,0 +1 @@ +mikrovaskulär-anastomosierten Transplantat[5-295.24 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Temporäre Tracheotomie[5-311.0 ] Freier Transfer Musculus latissimus dorsi Kopf und Hals[5-858.70 L] Tonsillektomie [ohne Adenotomie] mit Dissektionstechnik[5-281.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] \ No newline at end of file diff --git a/422/patient_clinical_data.json b/422/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..43d5ec273b0ddf770a7015c43923a24e87b19e39 --- /dev/null +++ b/422/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 50, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 21, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/422/patient_pathological_data.json b/422/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9fe65a5c2c57eeda553918730b37009997616f0d --- /dev/null +++ b/422/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "422", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 40, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 9.0 +} \ No newline at end of file diff --git a/422/surgery_description.txt b/422/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..0eac47b049fd46c2d2d61b4e230dcbc6ca143b45 --- /dev/null +++ b/422/surgery_description.txt @@ -0,0 +1 @@ +Transoral Resection, Tracheostomy creation, Bilateral neck dissection (Level II-V), Defect coverage diff --git a/422/surgery_report.txt b/422/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..adf82baea6b03c03122794a510ba3b1abb8e1ff5 --- /dev/null +++ b/422/surgery_report.txt @@ -0,0 +1 @@ +The patient is first taken to the operating room and prepared by the anesthesia colleagues. Tracheotomy: Horizontal skin incision at the level of the cricoid. Separation of the skin and subcutaneous tissue. Identification of the infralaryngeal musculature and division of the musculature in the midline. Sharp dissection of the cricoid cartilage. Identification of the thyroid isthmus and undermining of the isthmus with a clamp. Separation of the isthmus after bipolar coagulation and identification of the anterior tracheal wall. Creation of a visor tracheotomy between the 2nd and 3rd tracheal cartilage. Epithelialization of the tracheostoma in the usual manner and insertion of a 9-gauge cannula. Subsequent attempt at PEG insertion. PEG insertion not possible, therefore secondary insertion by surgical or internal medicine colleagues if diaphanoscopy is insufficient. Subsequent transoral tumor resection. Positioning of the head. Insertion with the McIvor oral spatula. Successive resection of the tumor with a safety margin of 1 to 1.5 cm on all sides. Here too, the mucosa is first pushed away from the hard palate, the palatal bone is already resected in the marginal area. The entire tonsil with the adjacent palatal arch area falls from left to right. The tumor is successfully removed in toto with a macroscopic safety margin on all sides. The tumor is thread-marked. A marginal sample is taken from the mucosal area in the posterior palatal arch at the border to the vomer. The specimen and marginal sample are sent for frozen section. In the frozen section, according to the pathology department, there is still a CIS in the caudal region on both sides, i.e. in the area of the mucosa below the tonsil lobe. Equally uncertain situation with CIS that cannot be ruled out in the area of the marginal sample in the direction of the vomer. Therefore, extensive resection of a mucosal strip in the area of the mucosal transition from the lower tonsil pole towards the hypopharynx. This is done from both sides, whereby the marginal samples are sent in 2 parts. Likewise, clear resection with further removal of the vomer and subsequent resection of the soft tissue behind and below it. All soft tissue and bone parts are sent for frozen section. No more carcinoma in situ infiltrates detectable here. Therefore now R0 resection. Neck dissection on the right side by : skin incision and dissection through the subcutaneous fatty tissue. Exposure of the platysma and subplatysmal blunt dissection. Finding the external jugular vein. This is extremely thick and has a bifurcation. Ligation of the medial part and preservation and retraction of the lateral part. Dissection of the anterior margin of the sternocleidomastoid muscle and identification of the omohyoid muscle. Dissection along this and exposure of the submandibular muscle. Elevation of the submandibular glenoid with the Langenbeck and lateral dissection on the digastric muscle. Identification of the accessorius nerve and preservation of this. Now dissect the cervical vascular sheath and dissect the internal jugular vein cranially. Preservation of the facial nerve and finding and preserving the hypoglossal nerve. Now successive removal of the lateral neck preparation while sparing the accessorius nerve and the plexus branches. Identification of the vagus nerve and protection of this. Now also successive removal of the medial neck preparation. There is no evidence of bleeding. Insertion of a Redon drainage and two-layer wound closure. Neck dissection on the left side through : Skin incision on the anterior edge of the sternocleidomastoid muscle. Separation of the cutaneous and subcutaneous tissue. Separation of the platysma. Subplatysmal dissection of a skin flap. Identification of the external jugular vein and the auricular nerve. The nerve can be pushed upwards and preserved, the external jugular vein is ligated and cut. Dissection along the sternocleidomastoid muscle in depth with constant use of bipolar coagulation. Identification of the deep cervical fascia and the plexus branches of the cervical plexus as well as the accessorius nerve. Identification of the omohyoid muscle and dissection along the muscle medially to the hyoid bone. Identification of the posterior digastric venter muscle and dissection along the muscle anteriorly to the hyoid bone. The cervical lymph node regions II, III and IV as well as I b are removed after free dissection of the submandibular gland and removal of the surrounding lymph nodes. The neurovascular structures can be preserved. No major bleeding and no injury to the accessorius nerve. For the planned flap anastomosis, the superior thyroid artery is conditioned and dissected free and the internal jugular vein is dissected free in a circular fashion. The latissimus dorsi flap is then removed. First position the patient so that the left latissimus dorsi flap can be removed accordingly. (, maxillofacial surgery). The flap is then removed and a vascular connection is made, also by the anesthesia colleagues. Skin closure in the cervical area on both sides in a typical manner with insertion of a Redon drain in each case. Careful hemostasis and irrigation beforehand. Further inspection of the flap enorally. This is vital. Completion of the procedure without complications. Patient goes to the Medical Intensive Care Unit 1 for monitoring. Please continue antibiotic treatment with Unacid, which was started intraoperatively, for 1 week. Flap control according to the scheme for 5 days. Nutrition via the intraoperatively inserted gastric tube. Please arrange for a PEG to be inserted at intervals by the surgical or anesthesia colleagues once the wound has healed. After receiving the final histology, the patient will be presented at our interdisciplinary tumor conference. Overall cT3-4 oropharyngeal carcinoma in the palatal arch area. \ No newline at end of file diff --git a/423/InvasionFront_CD3_block11_x1_y9_patient423_0.json b/423/InvasionFront_CD3_block11_x1_y9_patient423_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3a4a095e56e1b69cf0f18ee68799bc83c76d22b3 --- /dev/null +++ b/423/InvasionFront_CD3_block11_x1_y9_patient423_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3548.1, + "Centroid Y µm": 22063.3, + "Num Detections": 22830, + "Num Negative": 21955, + "Num Positive": 875, + "Positive %": 3.833, + "Num Positive per mm^2": 359.04 + } +} \ No newline at end of file diff --git a/423/InvasionFront_CD3_block11_x2_y9_patient423_1.json b/423/InvasionFront_CD3_block11_x2_y9_patient423_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f4d234644fb0a04d899d50394b5d1a3dc4635252 --- /dev/null +++ b/423/InvasionFront_CD3_block11_x2_y9_patient423_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6121.8, + "Centroid Y µm": 21913.4, + "Num Detections": 21690, + "Num Negative": 21120, + "Num Positive": 570, + "Positive %": 2.628, + "Num Positive per mm^2": 257.38 + } +} \ No newline at end of file diff --git a/423/InvasionFront_CD8_block11_x1_y9_patient423_0.json b/423/InvasionFront_CD8_block11_x1_y9_patient423_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ba154fb22b23aa8212ea02a173d53b8ef33fcb73 --- /dev/null +++ b/423/InvasionFront_CD8_block11_x1_y9_patient423_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6453.4, + "Centroid Y µm": 33097.0, + "Num Detections": 22223, + "Num Negative": 21633, + "Num Positive": 590, + "Positive %": 2.655, + "Num Positive per mm^2": 260.79 + } +} \ No newline at end of file diff --git a/423/InvasionFront_CD8_block11_x2_y9_patient423_1.json b/423/InvasionFront_CD8_block11_x2_y9_patient423_1.json new file mode 100644 index 0000000000000000000000000000000000000000..00560bbf56b93509821c7ac0f05be931c6f8fb45 --- /dev/null +++ b/423/InvasionFront_CD8_block11_x2_y9_patient423_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8988.9, + "Centroid Y µm": 33020.7, + "Num Detections": 12307, + "Num Negative": 12131, + "Num Positive": 176, + "Positive %": 1.43, + "Num Positive per mm^2": 142.95 + } +} \ No newline at end of file diff --git a/423/TumorCenter_CD3_block11_x1_y9_patient423_0.json b/423/TumorCenter_CD3_block11_x1_y9_patient423_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8db8b673769ffb58a04a02db8aa605842c07b394 --- /dev/null +++ b/423/TumorCenter_CD3_block11_x1_y9_patient423_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6497.1, + "Centroid Y µm": 21765.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/423/TumorCenter_CD3_block11_x2_y9_patient423_1.json b/423/TumorCenter_CD3_block11_x2_y9_patient423_1.json new file mode 100644 index 0000000000000000000000000000000000000000..694544e1dce2f9b44da1979716b4ad8e89128804 --- /dev/null +++ b/423/TumorCenter_CD3_block11_x2_y9_patient423_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9087.3, + "Centroid Y µm": 21894.1, + "Num Detections": 15158, + "Num Negative": 14301, + "Num Positive": 857, + "Positive %": 5.654, + "Num Positive per mm^2": 525.31 + } +} \ No newline at end of file diff --git a/423/TumorCenter_CD8_block11_x1_y9_patient423_0.json b/423/TumorCenter_CD8_block11_x1_y9_patient423_0.json new file mode 100644 index 0000000000000000000000000000000000000000..71bb9ed13416993bcc2df901c91b6b68bfbcd9bc --- /dev/null +++ b/423/TumorCenter_CD8_block11_x1_y9_patient423_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3840.3, + "Centroid Y µm": 22095.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/423/TumorCenter_CD8_block11_x2_y9_patient423_1.json b/423/TumorCenter_CD8_block11_x2_y9_patient423_1.json new file mode 100644 index 0000000000000000000000000000000000000000..320d71412c613d2d8bda3430a9ecee6f8f93aba8 --- /dev/null +++ b/423/TumorCenter_CD8_block11_x2_y9_patient423_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6528.6, + "Centroid Y µm": 21971.9, + "Num Detections": 16752, + "Num Negative": 16008, + "Num Positive": 744, + "Positive %": 4.441, + "Num Positive per mm^2": 409.12 + } +} \ No newline at end of file diff --git a/423/history_text.txt b/423/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..cb79535a211372ce504275c3531e75f989f11f3a --- /dev/null +++ b/423/history_text.txt @@ -0,0 +1 @@ +In the patient <2011>, a cT2 cN2c oropharyngeal carcinoma on the right was histologically confirmed during a panendoscopy. The immediate preoperative ultrasound showed a cN2c neck status with questionable infiltration of the internal jugular vein. \ No newline at end of file diff --git a/423/icd_codes.txt b/423/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45267912272317193de4d38602a30aa2d2a67aac --- /dev/null +++ b/423/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/423/ops_codes.txt b/423/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..920778364aabd2824ff6eab84d64d0aeee76dc38 --- /dev/null +++ b/423/ops_codes.txt @@ -0,0 +1 @@ +Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Temporäre Tracheotomie[5-311.0 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.x4 Sonstige Entnahme und Transplantation sonstiges Transplantat mit mikrovaskuläre Anastomosierung Unterarm[5-858.x3 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] \ No newline at end of file diff --git a/423/patient_clinical_data.json b/423/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ca0c80542ec7aa37d96108ee9a2f08640bb01861 --- /dev/null +++ b/423/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 55, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": null, + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 32, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/423/patient_pathological_data.json b/423/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..28eb46447830fdb282c4a6f7f322b888f4e3017a --- /dev/null +++ b/423/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "423", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN2", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 10.0, + "number_of_resected_lymph_nodes": 67, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 12.0 +} \ No newline at end of file diff --git a/423/surgery_description.txt b/423/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..8f6c7143878002aea42b244a90910fea4fca3832 --- /dev/null +++ b/423/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Neck dissection, Free flap (Radial) diff --git a/423/surgery_report.txt b/423/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3329732a87417b5dbca55a9cb1e40b0ab2e52b64 --- /dev/null +++ b/423/surgery_report.txt @@ -0,0 +1 @@ +First perform a pharyngoscopy. Insertion of the open mouth retractors. An exophytic tumor can be seen in the area of the anterior palatal arch, sitting on the ascending mandibular branch, coarsely caked here and rather difficult to move. Growth to parauvular. The tonsillar lodge is used up, also clear infiltration of the posterior palatal arch. Growth continues over the glossotonsillar groove into the edge of the tongue, which is also circumscribed towards the posterior floor of the mouth and extends to approx. 3 cm in the area of the edge of the tongue as well as clear infiltration of the base of the tongue to approx. 1/4. Caudally in the area of the pharyngeal side wall, the tumor extends caudally to about the level of the oropharyngeal border. Epiglottis, vallecula and supraglottic region are free. The posterior wall of the oropharynx is also free. Now resection of the tumor transorally with the electric knife and using the dissection technique. Resection hard to parauvular while maintaining a safety margin of at least 1-1.5 cm. Removal of the entire anterior palatal arch, resection up to the buccal. Resection of the posterior palatal arch en bloc, in the area of the ascending mandibular branch here periosteal growth, but no infiltration. Infiltration of medial pterygoid muscles, therefore now exposure of the mandibular bone in the area of the ascending mandibular branch, pushing off the periosteum here with the raspatory. Resection of the posterior floor of the mouth and the edge of the tongue. Here too, maintaining a safety margin of at least 1 to 1.5 cm on all sides. Resection up to the base of the tongue and, in the case of resection in the area of the posterior floor of the mouth, exposure of the submandibular gland enorally after detachment of the tumor from the posterior pharyngeal wall. After complete detachment, the tumor is now left in the area of the posterior floor of the mouth and the base of the tongue, and the decision is made to proceed transcervically with better local control. Later, the parts of the lower jaw close to the tumor are also trimmed with the rose bur. Covering samples are now taken from the edges of the tongue, the posterior floor of the mouth, the soft palate and the buccal mucosa. These are assessed as completely tumor-free in the frozen section diagnostics. Now repositioning and turning to the neck dissection with tumor resection on the right side. Skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and preservation of the external jugular vein and the auricularis magnus nerve. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle, exposure of the digastric muscle and the submandibular gland. Exposure and free dissection of the internal jugular vein, careful dissection here. A clearly caked lymph node conglomerate can now be seen in the area of the venofacial angle. The facial vein itself is only very weakly developed and must be removed in the area of the metastases. Otherwise, there are no other internal jugular veins. The jugular vein is not infiltrated after careful dissection. Clearing of the anterior neck preparation with careful protection of the superior thyroid artery. Expose the hypoglossal nerve. Now expose the accessorius nerve. Clearing of the accessorius triangle with careful protection of the nerve and clearing of level Vb with careful protection of the cervical plexus branches. Subcapsular release of the submandibular gland. Resection of the digastric muscle, subtotal removal of the gland and thus performance of the pharyngotomy. The pharyngotomy is opened in the anterior region of the resection margins. Now reopen the mouth retractor and perform a combined resection towards the base of the tongue caudally to the vallecula and from the outside to the level of the hyoid. The tongue base resection is now separated from the cranial oropharyngeal resection for a better overview. Now turn back to the neck. It quickly becomes apparent that all branches of the external carotid artery and the cranial thyroid artery lead to the tumor. The facial and lingual arteries are therefore ligated, as is the maxillary artery. The internal carotid artery is now separated together with the vagus nerve from the superior pharyngeal constrictor muscle up to the level of the styloid process and thus safely spared. Using the styloid process as a landmark, the entire lateral pharyngeal musculature is resected from caudal to cranial up to the posterior pharyngeal wall. Now repeat the procedure enorally. The styloid process can also be identified here and serve as a guide for the resection. In the end, a 5 cm resectate is created. Due to the large wound area, 3 separate marginal samples are taken from the wound bed. In addition to the posterior pharyngeal wall central margin sample and the vallecula and hyoid margin samples. These are later all assessed as tumor-free. Therefore, an intraoperative R0 resection can be assumed here. Finally, as described above, the areas of growth close to the periosteum in the area of the ascending alveolar ridge are removed with the drill. Moderate connection conditions now remain on the right side in the area of the right external jugular vein and the remaining superior thyroid artery. Therefore, after previously measuring a graft adapted for the soft palate, tongue, tongue edge and floor of the mouth with a total area of 11 x 8 cm, a radial graft is lifted with special consideration of the posterior floor of the mouth and the edge of the tongue with the possibility of bilateral connection. Therefore, the radial flap is now lifted in parallel. Unwrap the arm and apply the tourniquet. After marking the graft, cut around the graft. Exposure and securing of the cephalic vein. Perform the same maneuver and expose the radial superficial ramus nerve. These can be completely spared. Exposure of the brachioradialis muscle and the cephalic vein. A skin monitor is not used in the course of potential bilateral anastomosis. Exposure of the radial veins, these are relatively slender distally. Blunt exposure Ligation of the distal vascular pedicle. Release of the distal vascular pedicle. Now strictly subfascial dissection. Further release of the graft. Circumscribed visible ulnar artery, but no further dissection and safe protection. Now complete subfascial elevation of the graft, exposing a cancerous bridge between the radial vein and cephalic vein in the area of the crook of the elbow. Salvage of this bridge, clipping of outgoing venous branches. Exposure of the radial artery before the exit of the very strong and significantly larger ulnar artery; a true anterior interosseous artery is not found here. Marking of the artery and reopening of the tourniquet. After a total of 90 minutes, minute hemostasis, regular flap perfusion and preparation for subsequent flap elevation. After graft displacement, an 11 x 8 cm piece of full-thickness skin is removed from the groin. In the groin area, after strict cutaneous elevation, subcutaneous mobilization and, if the wound is dry, placement of a 10-gauge Redon drainage and careful, strong, two-layer wound closure and later incorporation of the full-thickness skin graft and here, after careful wound inspection, two-layer wound closure. Complete incorporation of the full-thickness skin graft in this case with a complex flap, therefore somewhat more difficult incorporation conditions, but finally sufficient closure, application of a vacuum seal and application of the Kramer splint in the usual manner. At the same time, the neck dissection was performed on the left side. To do this, also make a skin incision on the anterior edge of the sternocleidomastoid muscle, cut through the skin and subcutaneous tissue. Separation of the playtsma. Creation of a platysma flap, exposure of the external jugular vein, which is very narrow here, and the auricular nerve. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Exposure of the anterior neck preparation with careful protection of the cervical artery and the very slender superior thyroid artery. Exposure and preservation of the hypoglossal nerve. Exposure and free preparation of the internal jugular vein. A macroscopically conspicuous lymph node measuring approx. 2 x 1.5 cm without infiltration of neighboring structures can be seen in the area of the jugulofacial angle. V. facialis is relatively weakly developed here, but is preserved. Exposure of the accessorius nerve. Careful release of the accessorius triangle with careful protection of the nerve and release of level V with careful protection of the cervical plexus branches. Finally, dry wound conditions and no evidence of lymph leakage in level V. After wound irrigation with Ringer's solution, insertion of a 10-gauge Redon drain and careful two-layer wound closure with primary graft connection attempt on the right side. Now perform a plastic tracheotomy. To do this, make a horizontal skin incision sparingly to avoid a possible connection to the cervical resection areas. Cut through skin and subcutaneous tissue. Cut through the infrahyoid muscles. Exposure of the cricoid cartilage, exposure of the anterior surface of the trachea. Bipolar coagulation of the very thin thyroid isthmus. Further exposure of the anterior surface of the trachea. Insertion between the 1st and 2nd tracheal ring: creation of a broad-based pedunculated Björk flap. Incision of the tracheostoma with mucocutaneous anastomosis and subsequent problem-free intubation onto an LE tube. Later reintubation onto an 8-gauge cannula with inner core, which is fixed by suturing. Now, after recovery of the graft, incorporation of the graft transenorally. In this case, with significant tongue swelling and edematous conditions, relatively difficult insertion conditions. Laborious reconstruction of the soft palate and suturing in the area of the cheek soft tissue, the posterior floor of the mouth and the edge of the tongue. Overall, however, a good fit. Finally, transcervical suturing of the base of the tongue and the lateral pharyngeal wall. Finally, tight conditions and sufficient flap detachment. Now condition the vessels by free preparation of the cubital subcutaneous veins carried out in the evening. Now a good opportunity for adequate pedicle positioning. Careful fixation of the pedicle peripherally with Vicryl sutures. Separation of the superior thyroid artery after peripheral clipping. Here after opening good flow. Conditioning of the vessels and anastomosis with 8.8 Ethilon in relatively equal caliber conditions. This is initially successful. However, there is now a marked vulnerability in the area of both vessels. There are several tears in the vessels, so that a stable and tight anastomosis cannot be achieved despite several attempts at suturing. Therefore excision of the anastomosis. The flap artery and the superior thyroid artery are shortened and a new vascular anastomosis is performed. This is successful despite difficult suture conditions. Immediate regular venous return with good flap perfusion. Venous return is strong, but only via one of the two elevated cubital veins. Therefore clipping of the 2nd vein. Conditioning of the external jugular vein, which is thrombosed in the meantime, therefore shortening of the vein. Free preparation continued, irrigation with heparin. Finally, good flow and clear conditions. After removal of a thrombus, careful irrigation and sizing of a 2.5 mm coupler and subsequent problem-free venous anastomosis with the coupler. A well-positioned pedicle with relatively stable conditions and excellent flap perfusion enorally is now evident, so that careful two-layer wound closure with a caudally extended flap is now performed and the procedure is completed at this point. Conclusion: Due to the intraoperative extension cT3 cN2c oropharyngeal carcinoma on the right with R0 situation macroscopically and in the frozen section diagnosis. The patient received intraoperative intravenous antibiotics with Unacid 3 c. Postoperative regular enoral flap vitality control in the absence of a skin monitor. Due to the venous anastomosis located directly subcutaneously on the right side at the anterior edge of the sternocleidomastoid muscle, strict attention must be paid to avoiding pressure bandages or similar. Depending on the endoscopy findings, diet build-up and, if necessary, decannulation are possible from the 8th postoperative day. \ No newline at end of file diff --git a/424/InvasionFront_CD3_block9_x3_y9_patient424_0.json b/424/InvasionFront_CD3_block9_x3_y9_patient424_0.json new file mode 100644 index 0000000000000000000000000000000000000000..aba632dfd5bf2876180d351271d6f659c71b909a --- /dev/null +++ b/424/InvasionFront_CD3_block9_x3_y9_patient424_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11843.7, + "Centroid Y µm": 23187.7, + "Num Detections": 9351, + "Num Negative": 7982, + "Num Positive": 1369, + "Positive %": 14.64, + "Num Positive per mm^2": 1317.2 + } +} \ No newline at end of file diff --git a/424/InvasionFront_CD3_block9_x4_y9_patient424_1.json b/424/InvasionFront_CD3_block9_x4_y9_patient424_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6d428317d6d54e8ea9fca38b86b700290ffaf4d6 --- /dev/null +++ b/424/InvasionFront_CD3_block9_x4_y9_patient424_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14592.3, + "Centroid Y µm": 23287.7, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/424/InvasionFront_CD8_block9_x3_y9_patient424_0.json b/424/InvasionFront_CD8_block9_x3_y9_patient424_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f3c6add34b0c8ca3214f32d40ff86689d17458f7 --- /dev/null +++ b/424/InvasionFront_CD8_block9_x3_y9_patient424_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11943.7, + "Centroid Y µm": 26760.8, + "Num Detections": 12601, + "Num Negative": 11380, + "Num Positive": 1221, + "Positive %": 9.69, + "Num Positive per mm^2": 841.81 + } +} \ No newline at end of file diff --git a/424/InvasionFront_CD8_block9_x4_y9_patient424_1.json b/424/InvasionFront_CD8_block9_x4_y9_patient424_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7a62445aa99dc31d598078e49fe0a789d1404cbe --- /dev/null +++ b/424/InvasionFront_CD8_block9_x4_y9_patient424_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14842.1, + "Centroid Y µm": 26885.8, + "Num Detections": 11786, + "Num Negative": 10006, + "Num Positive": 1780, + "Positive %": 15.1, + "Num Positive per mm^2": 1238.8 + } +} \ No newline at end of file diff --git a/424/TumorCenter_CD3_block9_x3_y9_patient424_0.json b/424/TumorCenter_CD3_block9_x3_y9_patient424_0.json new file mode 100644 index 0000000000000000000000000000000000000000..43715d21d8c94f36a15ff40dce44e911b7ccba9f --- /dev/null +++ b/424/TumorCenter_CD3_block9_x3_y9_patient424_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10919.2, + "Centroid Y µm": 28135.1, + "Num Detections": 23967, + "Num Negative": 21430, + "Num Positive": 2537, + "Positive %": 10.59, + "Num Positive per mm^2": 1092.8 + } +} \ No newline at end of file diff --git a/424/TumorCenter_CD3_block9_x4_y9_patient424_1.json b/424/TumorCenter_CD3_block9_x4_y9_patient424_1.json new file mode 100644 index 0000000000000000000000000000000000000000..48642120258efc500109cd25efc43789a2156dab --- /dev/null +++ b/424/TumorCenter_CD3_block9_x4_y9_patient424_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13642.8, + "Centroid Y µm": 28160.1, + "Num Detections": 11331, + "Num Negative": 8775, + "Num Positive": 2556, + "Positive %": 22.56, + "Num Positive per mm^2": 1938.4 + } +} \ No newline at end of file diff --git a/424/TumorCenter_CD8_block9_x3_y9_patient424_0.json b/424/TumorCenter_CD8_block9_x3_y9_patient424_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f9937e111965f90e3e55255cba4e647e90a86811 --- /dev/null +++ b/424/TumorCenter_CD8_block9_x3_y9_patient424_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11443.9, + "Centroid Y µm": 23687.5, + "Num Detections": 24132, + "Num Negative": 21719, + "Num Positive": 2413, + "Positive %": 9.999, + "Num Positive per mm^2": 1033.8 + } +} \ No newline at end of file diff --git a/424/TumorCenter_CD8_block9_x4_y9_patient424_1.json b/424/TumorCenter_CD8_block9_x4_y9_patient424_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f88e9fae1669142d9b7cbc865ecd44d7ca537c8 --- /dev/null +++ b/424/TumorCenter_CD8_block9_x4_y9_patient424_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14217.5, + "Centroid Y µm": 23487.6, + "Num Detections": 8551, + "Num Negative": 7161, + "Num Positive": 1390, + "Positive %": 16.26, + "Num Positive per mm^2": 1296.8 + } +} \ No newline at end of file diff --git a/424/history_text.txt b/424/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..1285ba793d9a8fa34f3bbc790fa8951960d99198 --- /dev/null +++ b/424/history_text.txt @@ -0,0 +1 @@ +The patient <2014> underwent a panendoscopy to histologically confirm a low-grade differentiated squamous cell carcinoma in the right oropharyngeal region, overall cT2 cN2b G3 cM0 oropharyngeal carcinoma on the right. In our interdisciplinary tumor conference, primary surgical treatment was recommended. The patient had polytoxicomania with a history of C2 withdrawal. \ No newline at end of file diff --git a/424/icd_codes.txt b/424/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..914febab322d93a8d2df607d8ed5a25e9641dd17 --- /dev/null +++ b/424/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Seitenwand des Oropharynx[C10.2 ] \ No newline at end of file diff --git a/424/ops_codes.txt b/424/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..69259004f65dd83ad7e271bb0de715d5fd90471c --- /dev/null +++ b/424/ops_codes.txt @@ -0,0 +1 @@ +Radikale Resektion des Pharynx [Pharyngektomie] durch Pharyngotomie mit Rekonstruktion mit gestieltem Fernlappen[5-296.15 ] Entnahme eines gestielten Fernlappens an der Schulter[5-904.26 R] Radikale Neck dissection in 5 Regionen[5-403.11 R] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 L] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/424/patient_clinical_data.json b/424/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..87621e6953a6c1190c1747e4f78964a6f4097042 --- /dev/null +++ b/424/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 44, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased not tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 43, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/424/patient_pathological_data.json b/424/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..212fdf529c7329db358a098256857c37e83ca985 --- /dev/null +++ b/424/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "424", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 8.0, + "number_of_resected_lymph_nodes": 43, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/424/surgery_description.txt b/424/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..26771a0a2b5974cdd5a5a34571120503e5cb7f25 --- /dev/null +++ b/424/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Pedicled flap (supraclavicular) diff --git a/424/surgery_report.txt b/424/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..37774e4a723bc3247a9fec6c6da2e12a789455b5 --- /dev/null +++ b/424/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, the first step is to determine the expansion again. Entry with the small bore tube under dental protection. The oral cavity is unremarkable on inspection and palpation. In the area of the oropharynx on the right, the exophytic mass can be seen starting at the caudal tonsil pole and extending caudally over the lateral pharyngeal wall. In the caudal extension, it extends to the entrance of the piriform sinus. However, the piriform sinus itself is free, as is the posterior pharyngeal wall. Growth across the pharyngoepiglottic fold towards the vallecula and the base of the tongue. The base of the tongue itself is not infiltrated in depth, here only superficial, circumscribed growth, but the right-sided vallecula and here extensions onto the lingual epiglottis. Overall, the T3 stage is already reached here due to the surface extension. A safe transoral resection is not possible due to the growth, the extension and the restricted mouth opening in the case of a mandibular fracture. The decision was therefore made to proceed primarily transverically. Repositioning of the patient. There is extensive lymph node metastasis on the right side, sonographically cN2b. Clinically, there is an extensive conglomerate, especially in level II and extending from here to level V a dorsally. Injection of xylocaine with the addition of adrenaline. Skin incision on the anterior edge of the sternocleidomastoid muscle extending nuchally. Cut through skin and subcutaneous tissue. Exposure and dissection of the platysma, which is not yet infiltrated. Exposure of the sternocleidomastoid muscle. Wide infiltration in the cranial part, therefore exposure of the omohyoid muscle. Release of the submandibular gland. Exposure of the digastric muscle, which is also not infiltrated. Separation of the sternocleidomastoid muscle caudally. Exposure and free preparation of the internal jugular vein, here a strong thyroid vein. On cranial dissection, however, the vein is clearly infiltrated, so that it is removed here. The facial vein is also removed. Exposure and preservation of the common carotid artery and vagus nerve. The hypoglossal nerve can also be preserved. Partial entrainment of the cervical plexus, otherwise en bloc development of level V a. Protection of the transverse cervical artery. Cranial detachment of the muscle from the sternocleidomastoid muscle. Supply of the internal jugular vein and en bloc removal of the neck preparation with the metastatic conglomerate. This is followed by partial release of the thyroid cartilage to release the right piriform sinus. Exposure of the common carotid artery. Exposure and isolation of the superior laryngeal nerve. Release of the pharyngeal side wall cranially into the tonsillar ligament with reduction of the digastric muscle. It is now apparent that the superior laryngeal nerve runs directly into the tumor conglomerate, so it is removed. Entering the pharynx below the expected tumor in the area of the piriform sinus. Free conditions here. Development of the tumor and successive resection and widening of the pharyngotomy. Removal of half of the epiglottis. Removal of a large cuff at the base of the tongue. Resection down to the pre-epiglottic fatty tissue. Cranial removal of the glossotonsillar groove as well as the entire tonsillar lobe up to the cranial side. Overall, a safety margin of at least 1 to 1.5 cm was maintained on all sides with a rather superficially growing tumor. Laterally, the entire musculature was removed to cover the basal part. Overall, however, the specimen was somewhat vulnerable, so that the explicit suture markings were made in all planes. Despite macroscopic in sano resection, the tumor was found to be margin-forming on all sides after embedding for the pathology colleagues, but the tissue was probably easy to tear. In the basal area, the mass was barely resected in sano, but without taking into account the overlying muscle tissue, so that a safe removal can be assumed here. After discussing the case with , the tumor was again completely covered in situ with margin samples. All margins were found to be free of tumor and dysplasia, so that a histological R0 situation can now be assumed based on the findings. In the meantime, the neck was dissected on the left side and a tracheotomy was performed. Neck dissection on the left: Skin incision at the anterior border of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle and exposure of the omohyoid muscle. Release of the submandibular gland and visualization of the digastric muscle. Release of the anterior neck preparation while carefully protecting the facial vein, the superior thyroid artery and the cervical artery as well as the hypoglossal nerve. Free preparation of the internal jugular vein. Exposure and preservation of the accessorius nerve. Some enlarged nodes in level II, otherwise no suspicious changes. Clearing of the accessorius triangle and completion of level V with careful protection of the cervical plexus branches. Finally, inspect the wound and, if the wound is dry, insert a 10-gauge Redon drain and carefully close the wound in two layers. Now perform the tracheotomy: To do this, make a horizontal incision below the cricoid cartilage. Cut through the skin and subcutaneous tissue. Expose the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Exposure of the thyroid isthmus and transection. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based Björk flap and insertion of the tracheostoma in the usual manner. At the end of the procedure, reintubation to a size 8 low-cuff cannula, which is suture-fixed. Due to the radical neck dissection of the right side and the defect configuration, the decision was made to lift a pedicled, supraclavicular island flap from the right. Measurement and marking of a graft measuring 6 x 11 cm in total, including the acromion. Trimming of the graft, strictly subfascial preparation. Dissection of the skin in the shoulder area. Lifting of a wide vascular pedicle and subsequent tension-free, but complex suturing of the vital flap. Subsequently tight conditions on all sides. Reconstruction of the tonsil lobe up to the posterior pharyngeal wall. Reconstruction of the entire pharyngeal side wall up to the piriform sinus as well as the base of the tongue and the transition to the supraglottic region. Subsequent careful wound inspection. Insertion of a total of 3 10 Redon drains and careful, two-layer wound closure. Subsequent completion of the procedure without any indication of complications. Conclusion: Intraoperative R0-resected cT3 cN2b oropharyngeal carcinoma on the right. Please perform a postoperative X-ray gruel swallow on the 8th postoperative day. Due to the extensive partial pharyngeal resection, a prolonged recovery of swallowing function can be expected. With final confirmation of the intraoperatively performed marginal samples, this is a safe R0 resection. \ No newline at end of file diff --git a/425/InvasionFront_CD3_block20_x1_y5_patient425_0.json b/425/InvasionFront_CD3_block20_x1_y5_patient425_0.json new file mode 100644 index 0000000000000000000000000000000000000000..cc037905b885d86e996c211525a6e3ce463f64e1 --- /dev/null +++ b/425/InvasionFront_CD3_block20_x1_y5_patient425_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5097.3, + "Centroid Y µm": 11868.7, + "Num Detections": 25982, + "Num Negative": 20585, + "Num Positive": 5397, + "Positive %": 20.77, + "Num Positive per mm^2": 1886.7 + } +} \ No newline at end of file diff --git a/425/InvasionFront_CD3_block20_x2_y5_patient425_1.json b/425/InvasionFront_CD3_block20_x2_y5_patient425_1.json new file mode 100644 index 0000000000000000000000000000000000000000..26926de5d4d09f2561df2eb50dd170d9776710d2 --- /dev/null +++ b/425/InvasionFront_CD3_block20_x2_y5_patient425_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7745.9, + "Centroid Y µm": 12043.6, + "Num Detections": 21959, + "Num Negative": 17420, + "Num Positive": 4539, + "Positive %": 20.67, + "Num Positive per mm^2": 1791.7 + } +} \ No newline at end of file diff --git a/425/InvasionFront_CD8_block20_x1_y5_patient425_0.json b/425/InvasionFront_CD8_block20_x1_y5_patient425_0.json new file mode 100644 index 0000000000000000000000000000000000000000..5392eeb297c5679a16e1700688c48051c7cc1161 --- /dev/null +++ b/425/InvasionFront_CD8_block20_x1_y5_patient425_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4122.8, + "Centroid Y µm": 13093.1, + "Num Detections": 25236, + "Num Negative": 18844, + "Num Positive": 6392, + "Positive %": 25.33, + "Num Positive per mm^2": 2291.4 + } +} \ No newline at end of file diff --git a/425/InvasionFront_CD8_block20_x2_y5_patient425_1.json b/425/InvasionFront_CD8_block20_x2_y5_patient425_1.json new file mode 100644 index 0000000000000000000000000000000000000000..402d1ad5f0019d90e4361d3eaf205f745fd8eed5 --- /dev/null +++ b/425/InvasionFront_CD8_block20_x2_y5_patient425_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6871.4, + "Centroid Y µm": 12918.2, + "Num Detections": 20996, + "Num Negative": 14572, + "Num Positive": 6424, + "Positive %": 30.6, + "Num Positive per mm^2": 2545.8 + } +} \ No newline at end of file diff --git a/425/TumorCenter_CD3_block20_x1_y5_patient425_0.json b/425/TumorCenter_CD3_block20_x1_y5_patient425_0.json new file mode 100644 index 0000000000000000000000000000000000000000..80528c07ce90ee7180e3b811aad2ed3efa847793 --- /dev/null +++ b/425/TumorCenter_CD3_block20_x1_y5_patient425_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3783.4, + "Centroid Y µm": 11770.0, + "Num Detections": 20762, + "Num Negative": 18607, + "Num Positive": 2155, + "Positive %": 10.38, + "Num Positive per mm^2": 943.44 + } +} \ No newline at end of file diff --git a/425/TumorCenter_CD3_block20_x2_y5_patient425_1.json b/425/TumorCenter_CD3_block20_x2_y5_patient425_1.json new file mode 100644 index 0000000000000000000000000000000000000000..42f6ffe563a631c1f12c46430ede2d8531e18861 --- /dev/null +++ b/425/TumorCenter_CD3_block20_x2_y5_patient425_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6416.7, + "Centroid Y µm": 11860.9, + "Num Detections": 17757, + "Num Negative": 15733, + "Num Positive": 2024, + "Positive %": 11.4, + "Num Positive per mm^2": 973.58 + } +} \ No newline at end of file diff --git a/425/TumorCenter_CD8_block20_x1_y5_patient425_0.json b/425/TumorCenter_CD8_block20_x1_y5_patient425_0.json new file mode 100644 index 0000000000000000000000000000000000000000..65e2911b509e065ff948cb6744660b930b6d1a97 --- /dev/null +++ b/425/TumorCenter_CD8_block20_x1_y5_patient425_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3298.3, + "Centroid Y µm": 12793.2, + "Num Detections": 17876, + "Num Negative": 11874, + "Num Positive": 6002, + "Positive %": 33.58, + "Num Positive per mm^2": 2864.3 + } +} \ No newline at end of file diff --git a/425/TumorCenter_CD8_block20_x2_y5_patient425_1.json b/425/TumorCenter_CD8_block20_x2_y5_patient425_1.json new file mode 100644 index 0000000000000000000000000000000000000000..4aea7b13d342adab7724a1e2256f7ac612913ac7 --- /dev/null +++ b/425/TumorCenter_CD8_block20_x2_y5_patient425_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5846.9, + "Centroid Y µm": 12743.3, + "Num Detections": 18102, + "Num Negative": 12042, + "Num Positive": 6060, + "Positive %": 33.48, + "Num Positive per mm^2": 2680.0 + } +} \ No newline at end of file diff --git a/425/history_text.txt b/425/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..cc8484fa73cca8dc4569062148b86aa21bec8f8b --- /dev/null +++ b/425/history_text.txt @@ -0,0 +1 @@ +The patient was diagnosed with cT2 squamous cell carcinoma in the area of the laryngeal epiglottis during a panendoscopy <2014>. In our interdisciplinary tumor conference, it was decided to perform a transoral resection, in this case with TORS. \ No newline at end of file diff --git a/425/icd_codes.txt b/425/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e2600f21064d352a417a66d19d566f98cd812904 --- /dev/null +++ b/425/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Supraglottis[C32.1 ] \ No newline at end of file diff --git a/425/ops_codes.txt b/425/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dad2ec5475cf8128c645b11b9908be46d6e9d40c --- /dev/null +++ b/425/ops_codes.txt @@ -0,0 +1 @@ +Epiglottektomie endolaryngeal[5-302.0 ] Partielle Larynx-Pharynx-Resektion[5-302.4 ] Selektive Neck dissection in 4 Regionen[5-403.03 B] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/425/patient_clinical_data.json b/425/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d31965d6f211e8ae15e9786d4487555730672964 --- /dev/null +++ b/425/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2014, + "age_at_initial_diagnosis": 70, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/425/patient_pathological_data.json b/425/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b8bf9e880314ac45e494fd228cadd718ddc14915 --- /dev/null +++ b/425/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "425", + "primary_tumor_site": "Larynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 13, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/425/surgery_description.txt b/425/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..c8321e59b0132aca7707f88024046a42d8f213ad --- /dev/null +++ b/425/surgery_description.txt @@ -0,0 +1 @@ +TORS procedure on the Larynx, Neck dissection, Tracheotomy diff --git a/425/surgery_report.txt b/425/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..b8f6beefeccef20a788a534c07c97c47c5ba6833 --- /dev/null +++ b/425/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia and intubation by the anesthesia colleagues, the first step is to use the small bore tube to inspect the local findings. Inconspicuous oral cavity and oropharynx. In the area of the laryngeal epiglottis, a largely exophytic mass is now seen, as described above, but in comparison progressive in size, which occupies the majority of the laryngeal epiglottis area, extends caudally to just before the petiolus, laterally just reaches the aryepiglottic fold on the left, extends over this on the right side to the pocket fold and here to just before the ary, but no ary infiltration. Now adjust the findings with the FK retractor. The resection is then performed under 30° optics in a robot-assisted manner with complete resection of the epiglottis via the vallecula down to the petiolus. No penetrating growth here, so that there is no extension into the pre-epiglottic space. Resection on the left side of the aryepiglottic fold up to the left side above the pocket fold, on the right side complete resection of the aryepiglottic fold up to the ary and partial removal of the pocket fold. For an overview, the tumor is successively resected and retracted using the piecemeal technique. Finally, covering marginal samples are taken. These are completely tumor-free, so that the overall situation is R0. Subsequent careful hemostasis. If the enoral situation is dry, perform selective neck dissection on both sides. Right-sided evacuation of levels II to IV with ligation of the external jugular vein and facial vein. Preservation of the auricular nerve after exposure of the surrounding musculature. Exposure and preservation of the superior thyroid artery, cervical artery, hypoglossal nerve, internal jugular vein, accessorius nerve. Overall, macroscopically no conspicuous nodules. Subsequent careful wound irrigation with H2O2 and Ringer's solution. Insertion of a 10-gauge Redon drain and careful, two-layer wound closure. Turning to the left side. Exactly the same procedure here. Exposure of the bordering musculature. Ligation of the external jugular vein, which also runs obliquely. Also ligation of the facial vein. Overall, as on the opposite side, significantly more difficult preparation conditions with marked obesity and extremely short neck. Free preparation and preservation of the hypoglossal nerve, superior thyroid artery, accessorius nerve, internal jugular vein. Deposition of the preparation, as on the opposite side, at the transition to level V. Careful hemostasis. Irrigate the wound with H2O2 and Ringer's solution. If the wound is dry, insert a 10-gauge Redon drain and carefully close the wound in two layers. Then perform the tracheotomy. To do this, make a horizontal incision at the level of the very deep cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure and transection of the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Dissection of the thyroid isthmus. Insertion between the 1st and 2nd tracheal ring. Performing a wide tracheotomy. Incision of the tracheostoma in the usual manner. Subsequent problem-free transfer to a size 9 low-cuff cannula and repositioning of the patient. Completion of the procedure without any indication of complications. Note: The patient receives intraoperative intravenous antibiotics with Unacid 3 g, please continue this for 24 hours postoperatively. A nasogastric feeding tube should also be inserted intraoperatively. Please feed via this for 5 days, after which a swallowing test and, if necessary, a diet reconstruction are required. Due to the extensive supraglottic resection, there may be a protracted recovery of swallowing function. \ No newline at end of file diff --git a/426/InvasionFront_CD3_block2_x3_y2_patient426_0.json b/426/InvasionFront_CD3_block2_x3_y2_patient426_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2f8397f664a25107e7ac55976deb879671cc01b2 --- /dev/null +++ b/426/InvasionFront_CD3_block2_x3_y2_patient426_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 18590.2, + "Num Detections": 21598, + "Num Negative": 19932, + "Num Positive": 1666, + "Positive %": 7.714, + "Num Positive per mm^2": 649.26 + } +} \ No newline at end of file diff --git a/426/InvasionFront_CD3_block2_x4_y2_patient426_1.json b/426/InvasionFront_CD3_block2_x4_y2_patient426_1.json new file mode 100644 index 0000000000000000000000000000000000000000..922be273a9148b9c73a9bf3a594758d22403b39f --- /dev/null +++ b/426/InvasionFront_CD3_block2_x4_y2_patient426_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 18490.2, + "Num Detections": 19715, + "Num Negative": 18383, + "Num Positive": 1332, + "Positive %": 6.756, + "Num Positive per mm^2": 567.36 + } +} \ No newline at end of file diff --git a/426/InvasionFront_CD8_block2_x3_y2_patient426_0.json b/426/InvasionFront_CD8_block2_x3_y2_patient426_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3f89eb167c1a0419f7fb4cbdc1fde07f9e863b3e --- /dev/null +++ b/426/InvasionFront_CD8_block2_x3_y2_patient426_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12543.4, + "Centroid Y µm": 6121.8, + "Num Detections": 22352, + "Num Negative": 21370, + "Num Positive": 982, + "Positive %": 4.393, + "Num Positive per mm^2": 384.73 + } +} \ No newline at end of file diff --git a/426/InvasionFront_CD8_block2_x4_y2_patient426_1.json b/426/InvasionFront_CD8_block2_x4_y2_patient426_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1f4ab50b89c65ecab7f526e6d73dfcea6a9ab032 --- /dev/null +++ b/426/InvasionFront_CD8_block2_x4_y2_patient426_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15167.0, + "Centroid Y µm": 6096.8, + "Num Detections": 22232, + "Num Negative": 21376, + "Num Positive": 856, + "Positive %": 3.85, + "Num Positive per mm^2": 349.22 + } +} \ No newline at end of file diff --git a/426/TumorCenter_CD3_block2_x3_y2_patient426_0.json b/426/TumorCenter_CD3_block2_x3_y2_patient426_0.json new file mode 100644 index 0000000000000000000000000000000000000000..600b8ed348efc7a5e1142fd4348d9d88019df031 --- /dev/null +++ b/426/TumorCenter_CD3_block2_x3_y2_patient426_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11718.8, + "Centroid Y µm": 4847.4, + "Num Detections": 19022, + "Num Negative": 18590, + "Num Positive": 432, + "Positive %": 2.271, + "Num Positive per mm^2": 174.0 + } +} \ No newline at end of file diff --git a/426/TumorCenter_CD3_block2_x4_y2_patient426_1.json b/426/TumorCenter_CD3_block2_x4_y2_patient426_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ae717f3b0ea4e7c4a76251e12a30d22cbdbab13a --- /dev/null +++ b/426/TumorCenter_CD3_block2_x4_y2_patient426_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14242.5, + "Centroid Y µm": 4897.4, + "Num Detections": 16534, + "Num Negative": 15692, + "Num Positive": 842, + "Positive %": 5.093, + "Num Positive per mm^2": 436.1 + } +} \ No newline at end of file diff --git a/426/TumorCenter_CD8_block2_x3_y2_patient426_0.json b/426/TumorCenter_CD8_block2_x3_y2_patient426_0.json new file mode 100644 index 0000000000000000000000000000000000000000..350a999bde5c52239ebc7fa28988ee3e7b9f67e9 --- /dev/null +++ b/426/TumorCenter_CD8_block2_x3_y2_patient426_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12868.2, + "Centroid Y µm": 4697.5, + "Num Detections": 20058, + "Num Negative": 19915, + "Num Positive": 143, + "Positive %": 0.7129, + "Num Positive per mm^2": 57.3 + } +} \ No newline at end of file diff --git a/426/TumorCenter_CD8_block2_x4_y2_patient426_1.json b/426/TumorCenter_CD8_block2_x4_y2_patient426_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d6839d2118bf5b52340bc11a6c8ade24fd9891fc --- /dev/null +++ b/426/TumorCenter_CD8_block2_x4_y2_patient426_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15366.9, + "Centroid Y µm": 4572.6, + "Num Detections": 21744, + "Num Negative": 21163, + "Num Positive": 581, + "Positive %": 2.672, + "Num Positive per mm^2": 233.43 + } +} \ No newline at end of file diff --git a/426/history_text.txt b/426/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..4ff9b85dea6945aeae41777e38ac28ed0a89c444 --- /dev/null +++ b/426/history_text.txt @@ -0,0 +1 @@ +A cT1-2 p16-negative oral cavity/oropharyngeal carcinoma on the right side was histologically confirmed in the patient. There is now an indication for transoral tumor resection and elective right neck dissection in ITN. The patient had ample opportunity to ask questions about the procedure before the operation. \ No newline at end of file diff --git a/426/icd_codes.txt b/426/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a1b44d09c0b3b166d104bede4d1484b2d7869567 --- /dev/null +++ b/426/icd_codes.txt @@ -0,0 +1 @@ +Karzinom des weichen Gaumens[C05.1 ] \ No newline at end of file diff --git a/426/ops_codes.txt b/426/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..f018cfcf75b903ccba4f3303445fef752c360ded --- /dev/null +++ b/426/ops_codes.txt @@ -0,0 +1 @@ +Lokale Exzision erkranktes Gewebe Pharynx[5-292.0 ] Weichgaumenteilresektion[5-272.1 ] Transorale Tumortonsillektomie[5-281.2 ] Selektive Neck dissection in 4 Regionen[5-403.03 R] \ No newline at end of file diff --git a/426/patient_clinical_data.json b/426/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..56fb3fb6a9c3112300682af63f0c5d79a56c173d --- /dev/null +++ b/426/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 64, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 23, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/426/patient_pathological_data.json b/426/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..87e5d14263b246dc823cf4cbcb60b832aa665f2e --- /dev/null +++ b/426/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "426", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 10, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/426/surgery_description.txt b/426/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fb9fe50845867aaedc2f5fbc52df486747693f2c --- /dev/null +++ b/426/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Right-sided neck dissection diff --git a/426/surgery_report.txt b/426/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..168afea98a2c6f734109302b917a9701f6fe3b3b --- /dev/null +++ b/426/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with the anesthesiologist. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. First insertion of the McIvor oral spatula while protecting the teeth, lips and tongue. The resection margins are then marked using the electric needle. While maintaining the necessary safety distance, the tumor is now resected successively, taking the right tonsil with it. The extent of the resection extends to the alveolar ridge in the area of the former last and penultimate molar. A large part of the glossotonsillar groove is also resected. Clinically macroscopically clear in sano resection. The preparation is now sent in marked with a thread for frozen section diagnostics. In addition, a further marginal sample is taken from the glossotonsillar groove via the mucosa of the alveolar ridge to the anterior palatal arch. During the intraoperative frozen section, the tumor is classified as R0 on the specimen. The additional marginal sample taken is also free of tumor and carcinoma in situ. Hemostasis by means of bipolar coagulation. Insertion of an H2O2-soaked extracted hydrogen compress. Transition to neck dissection. First skin spray disinfection and infiltration anesthesia. Skin wipe disinfection and sterile draping. Marking of the mandibular arch and the ascending mandibular branch. Marking of the planned incision from the mastoid, extending into a submandibular skin fold and curving out at the anterior edge of the sternocleidomastoid muscle. Sharp cutting of the cutis as well as the subcutis. Cutting through the platysma. Insertion of the sharp retractors. Exposure of the anterior edge of the sternocleidomastoid muscle. Exposure of the external jugular vein and the auricularis magnus nerve. Both structures can be preserved. Displacement and, at the end of the operation, re-embedding of the auricularis magnus nerve in the sense of a neurolysis. Exposure of the omohyoid muscle as a caudal boundary. Exposure of the posterior digastric venter muscle as the cranial border. Turning to the cervical vascular sheath. Visualization of the internal jugular vein and the small venous angle. Identification of the accessorius nerve. Subsequent clearing of the lateral neck preparation via level II b, II a, III up to level IV, sparing all plexus branches. As part of the dissection, the common carotid artery, the bifurcation and the internal and external carotid artery are also exposed. The vagus nerve is also exposed and protected. Displacement and, at the end of the operation, re-embedding of the accessorius nerve and vagus nerve in the sense of a neurolysis. Subsequently turn to the medial neck preparation. First identification of the hypoglossal nerve. Protection of the same. Displacement and, at the end of the operation, re-embedding of the hypoglossal nerve in the sense of a neurolysis. Successive development of the medial neck preparation while leaving the submandibular gland intact. Hemostasis by means of bipolar coagulation. Wound irrigation with H2O2 and Ringer's solution. Insertion of a 10-gauge Redon drain. Removal of the retractors. Subcutaneous suture with Vicryl 4-0 and skin suture with Ethilon 5-0. Application of a wound dressing and a pressure bandage. Finally, enoral inspection. Again, no evidence of a persistent source of bleeding. Removal of the H2O2-soaked extracted dressing. Completion of the operation without complications. A nasogastric tube is then inserted by the anesthesia colleagues. Final consultation with the anesthesia department. \ No newline at end of file diff --git a/427/InvasionFront_CD3_block10_x1_y9_patient427_0.json b/427/InvasionFront_CD3_block10_x1_y9_patient427_0.json new file mode 100644 index 0000000000000000000000000000000000000000..112de8893a1f9617edbf7559b5d33cc1eac8b18e --- /dev/null +++ b/427/InvasionFront_CD3_block10_x1_y9_patient427_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4897.4, + "Centroid Y µm": 27710.3, + "Num Detections": 25622, + "Num Negative": 24385, + "Num Positive": 1237, + "Positive %": 4.828, + "Num Positive per mm^2": 460.47 + } +} \ No newline at end of file diff --git a/427/InvasionFront_CD3_block10_x2_y9_patient427_1.json b/427/InvasionFront_CD3_block10_x2_y9_patient427_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ddbcdb6c87673da4c3b223cc0c7cbd853d554a71 --- /dev/null +++ b/427/InvasionFront_CD3_block10_x2_y9_patient427_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7246.2, + "Centroid Y µm": 27960.2, + "Num Detections": 26550, + "Num Negative": 18843, + "Num Positive": 7707, + "Positive %": 29.03, + "Num Positive per mm^2": 2812.9 + } +} \ No newline at end of file diff --git a/427/InvasionFront_CD8_block10_x1_y9_patient427_0.json b/427/InvasionFront_CD8_block10_x1_y9_patient427_0.json new file mode 100644 index 0000000000000000000000000000000000000000..420fa25c4a59705e6e3ec81018fa1143cb00b380 --- /dev/null +++ b/427/InvasionFront_CD8_block10_x1_y9_patient427_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5097.3, + "Centroid Y µm": 28934.7, + "Num Detections": 27321, + "Num Negative": 26750, + "Num Positive": 571, + "Positive %": 2.09, + "Num Positive per mm^2": 212.5 + } +} \ No newline at end of file diff --git a/427/InvasionFront_CD8_block10_x2_y9_patient427_1.json b/427/InvasionFront_CD8_block10_x2_y9_patient427_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8dcd0d940fa3c269ea9c1f7ca8693eaa34f0c84a --- /dev/null +++ b/427/InvasionFront_CD8_block10_x2_y9_patient427_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7496.0, + "Centroid Y µm": 28959.7, + "Num Detections": 27745, + "Num Negative": 23756, + "Num Positive": 3989, + "Positive %": 14.38, + "Num Positive per mm^2": 1473.4 + } +} \ No newline at end of file diff --git a/427/TumorCenter_CD3_block10_x1_y9_patient427_0.json b/427/TumorCenter_CD3_block10_x1_y9_patient427_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f4d1f90c781de21ffff8bee1beaa6ab0a2ced9e0 --- /dev/null +++ b/427/TumorCenter_CD3_block10_x1_y9_patient427_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6846.4, + "Centroid Y µm": 22588.0, + "Num Detections": 18854, + "Num Negative": 18223, + "Num Positive": 631, + "Positive %": 3.347, + "Num Positive per mm^2": 291.23 + } +} \ No newline at end of file diff --git a/427/TumorCenter_CD3_block10_x2_y9_patient427_1.json b/427/TumorCenter_CD3_block10_x2_y9_patient427_1.json new file mode 100644 index 0000000000000000000000000000000000000000..deaaa322c49cc93cdb70b32e8cd76086c2983ef8 --- /dev/null +++ b/427/TumorCenter_CD3_block10_x2_y9_patient427_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 9270.1, + "Centroid Y µm": 22388.1, + "Num Detections": 23199, + "Num Negative": 22909, + "Num Positive": 290, + "Positive %": 1.25, + "Num Positive per mm^2": 125.66 + } +} \ No newline at end of file diff --git a/427/TumorCenter_CD8_block10_x1_y9_patient427_0.json b/427/TumorCenter_CD8_block10_x1_y9_patient427_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1e2dd6835f6d9805312e6a0f0c5fdafa557d00a6 --- /dev/null +++ b/427/TumorCenter_CD8_block10_x1_y9_patient427_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4222.8, + "Centroid Y µm": 23612.5, + "Num Detections": 17714, + "Num Negative": 17189, + "Num Positive": 525, + "Positive %": 2.964, + "Num Positive per mm^2": 243.39 + } +} \ No newline at end of file diff --git a/427/TumorCenter_CD8_block10_x2_y9_patient427_1.json b/427/TumorCenter_CD8_block10_x2_y9_patient427_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b6c1b07044db7c7138dabb2f3170a891440349ce --- /dev/null +++ b/427/TumorCenter_CD8_block10_x2_y9_patient427_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6646.5, + "Centroid Y µm": 23337.6, + "Num Detections": 22365, + "Num Negative": 21963, + "Num Positive": 402, + "Positive %": 1.797, + "Num Positive per mm^2": 170.93 + } +} \ No newline at end of file diff --git a/427/history_text.txt b/427/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..12983900a3f644d830cf3eff2d43cf0e226a8e53 --- /dev/null +++ b/427/history_text.txt @@ -0,0 +1 @@ +Mr. has a pN2b neck status on the left (<2023>), G3 differentiated, with Z.n. neck dissection left level I to V and panendoscopy without evidence of primarius from <2013>. The subsequent PET-CT scan showed an enhancement of the left tonsil region. Indication for the above-mentioned procedure. Secondary diagnosis: Post clear cell renal cell carcinoma on the right (nephrectomy <2012>). \ No newline at end of file diff --git a/427/icd_codes.txt b/427/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..962e4548ec52163c79b6ece15ea5dea9f308c08a --- /dev/null +++ b/427/icd_codes.txt @@ -0,0 +1 @@ +Neubildung unsicheren oder unbekannten Verhaltens: Lippe, Mundhöhle und Pharynx[D37.0 ] Bösartige Neubildung der Gaumenbogentonsillen[C09.1 ] \ No newline at end of file diff --git a/427/ops_codes.txt b/427/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3be7d89f90927605d987780ce13efc83fec33a7b --- /dev/null +++ b/427/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Transorale partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.00 ] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Diagnostische ÖGD[1-632 ] \ No newline at end of file diff --git a/427/patient_clinical_data.json b/427/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..aaef4fdff04320c35dbad14a882c3831901dd54c --- /dev/null +++ b/427/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 54, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 16, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/427/patient_pathological_data.json b/427/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f453edb7969e320847a6e6408a86ad42d6347bcf --- /dev/null +++ b/427/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "427", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN2b", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 25, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/427/surgery_description.txt b/427/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..5177cbfde50028836b94872678e0c1ef8e1fa582 --- /dev/null +++ b/427/surgery_description.txt @@ -0,0 +1 @@ +Pharyngeal partial resection, Tonsillectomy, PEG placement diff --git a/427/surgery_report.txt b/427/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..0ddcaa031c36b97aa39cbbd2d3f99860f44027a0 --- /dev/null +++ b/427/surgery_report.txt @@ -0,0 +1 @@ +After induction of anesthesia by the anesthesia department, transoral endotracheal intubation by the anesthesia colleagues. Positioning of the patient for TE on the left. Dental status determined. Insertion of the McIvor oral spatula. The left tonsil is superficially unremarkable, no exophytic mass, but caudally marked induration. This finding is taken into account during the subsequent resection according to the demo and discussion with . Now incision of the anterior palatal arch on the left, taking it along and intramuscular, step-by-step dissection in the caudal direction using the dissection technique. No evidence of major vascular bleeding under dissection technique. The dissection procedure is performed according to the instructions of . The tonsil is coarse in the caudal direction, for this reason resection with a safety margin of approx. 1 cm and thus resection of part of the left tongue base. The macroscopically resected specimen in sano is thread-marked (cranial margin of resection, caudal margin of resection, tongue margin, caudal margin of resection, glossotonsillar groove) and sent for frozen section examination. During this time, a PEG was inserted (described below in the report). Result of the frozen section examination: 2 cm large squamous cell carcinoma of the left tonsil. Cranial margin forming. Caudal resection in the area of the base of the tongue at a maximum of 1 mm with partial coagulation artifacts. Renewed demonstration of findings and decision to carry out resections at exactly the above-mentioned sites and then to take marginal samples for frozen section examination. Thus generous resection of these sites by . The resections are sent for final histology. Then representative marginal samples are taken from the above-mentioned sites, which are sent for frozen section. These then show no malignancy. Thus R0-resected T2 tonsillar carcinoma on the left. With now extensive defect from parauvular over the soft palate to caudal to the base of the tongue, renewed demonstration of findings on , hemostasis using bipolar, finally 2 adjacent sutures to suture over the lateral pharyngeal wall through . No more evidence of bleeding. No fatty tissue from the lateral pharyngeal wall. Operation completed without complications. Dental status fixed. All swabs complete. No bleeding. Report on PEG placement (see above): Insertion of the flexible esophagogastroscope under bite guard and constant air insufflation, the esophageal mucosa is free on all sides and without irritation, no mass. In the stomach, air insufflation and regular unfolding of the inconspicuous mucosal relief. Clearly visible positive diaphanoscopy. Now placement of a PEG tube using the thread pull-through method in the typical manner, approx. 2 transverse fingers below the costal arch. The patient received 3 g Unacid i.v. perioperatively. A PEG tube was inserted without any problems. Conclusion: R0-resected T2 tonsillar carcinoma on the left in a frozen section after left neck dissection with pN2b neck status (2/23) and placement of a PEG tube. Significantly larger tumor size intraoperatively in contrast to the initial findings. Procedure: Planning of a neck dissection on the right and, depending on swallowing function and local findings, if necessary, defect coverage of the large oropharyngeal defect that has now developed (see above) using a microvascular anastomosed flap graft. Presentation at the interdisciplinary tumor conference and histology discussion. \ No newline at end of file diff --git a/428/InvasionFront_CD3_block17_x3_y11_patient428_0.json b/428/InvasionFront_CD3_block17_x3_y11_patient428_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f22c89ce5c287d0832207b0b02839aec2a2fb679 --- /dev/null +++ b/428/InvasionFront_CD3_block17_x3_y11_patient428_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10544.4, + "Centroid Y µm": 32632.7, + "Num Detections": 12420, + "Num Negative": 12349, + "Num Positive": 71, + "Positive %": 0.5717, + "Num Positive per mm^2": 60.06 + } +} \ No newline at end of file diff --git a/428/InvasionFront_CD3_block17_x4_y11_patient428_1.json b/428/InvasionFront_CD3_block17_x4_y11_patient428_1.json new file mode 100644 index 0000000000000000000000000000000000000000..54f9216975a1d78b3ed8230a7c3554dce9dd91c5 --- /dev/null +++ b/428/InvasionFront_CD3_block17_x4_y11_patient428_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13118.1, + "Centroid Y µm": 32707.7, + "Num Detections": 17609, + "Num Negative": 17472, + "Num Positive": 137, + "Positive %": 0.778, + "Num Positive per mm^2": 68.99 + } +} \ No newline at end of file diff --git a/428/InvasionFront_CD8_block17_x3_y11_patient428_0.json b/428/InvasionFront_CD8_block17_x3_y11_patient428_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2bfea52406be52cc0cf32cd3e166912e58b2e760 --- /dev/null +++ b/428/InvasionFront_CD8_block17_x3_y11_patient428_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11194.1, + "Centroid Y µm": 27410.5, + "Num Detections": 12181, + "Num Negative": 11948, + "Num Positive": 233, + "Positive %": 1.913, + "Num Positive per mm^2": 193.51 + } +} \ No newline at end of file diff --git a/428/InvasionFront_CD8_block17_x4_y11_patient428_1.json b/428/InvasionFront_CD8_block17_x4_y11_patient428_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3ce48e8e255574c0d3007f053ffea79017a15e7d --- /dev/null +++ b/428/InvasionFront_CD8_block17_x4_y11_patient428_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 27435.5, + "Num Detections": 15117, + "Num Negative": 14976, + "Num Positive": 141, + "Positive %": 0.9327, + "Num Positive per mm^2": 90.93 + } +} \ No newline at end of file diff --git a/428/TumorCenter_CD3_block17_x3_y11_patient428_0.json b/428/TumorCenter_CD3_block17_x3_y11_patient428_0.json new file mode 100644 index 0000000000000000000000000000000000000000..9756a9fbacd5411c27bb80f58957ee982dcf2723 --- /dev/null +++ b/428/TumorCenter_CD3_block17_x3_y11_patient428_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10719.3, + "Centroid Y µm": 27135.6, + "Num Detections": 22236, + "Num Negative": 20375, + "Num Positive": 1861, + "Positive %": 8.369, + "Num Positive per mm^2": 787.56 + } +} \ No newline at end of file diff --git a/428/TumorCenter_CD3_block17_x4_y11_patient428_1.json b/428/TumorCenter_CD3_block17_x4_y11_patient428_1.json new file mode 100644 index 0000000000000000000000000000000000000000..275ca65adcac2c5eedcdee049ed9b853fb2e4e06 --- /dev/null +++ b/428/TumorCenter_CD3_block17_x4_y11_patient428_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13193.0, + "Centroid Y µm": 27185.6, + "Num Detections": 17525, + "Num Negative": 16746, + "Num Positive": 779, + "Positive %": 4.445, + "Num Positive per mm^2": 358.58 + } +} \ No newline at end of file diff --git a/428/TumorCenter_CD8_block17_x3_y11_patient428_0.json b/428/TumorCenter_CD8_block17_x3_y11_patient428_0.json new file mode 100644 index 0000000000000000000000000000000000000000..29c548e03d21e5728b16cdd66ccfb629ea798dcc --- /dev/null +++ b/428/TumorCenter_CD8_block17_x3_y11_patient428_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13692.7, + "Centroid Y µm": 40953.3, + "Num Detections": 22602, + "Num Negative": 21039, + "Num Positive": 1563, + "Positive %": 6.915, + "Num Positive per mm^2": 659.39 + } +} \ No newline at end of file diff --git a/428/TumorCenter_CD8_block17_x4_y11_patient428_1.json b/428/TumorCenter_CD8_block17_x4_y11_patient428_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b0896538f5ce1ecaa79f432e7b6f8d7d0795d168 --- /dev/null +++ b/428/TumorCenter_CD8_block17_x4_y11_patient428_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16341.3, + "Centroid Y µm": 40878.4, + "Num Detections": 19238, + "Num Negative": 18350, + "Num Positive": 888, + "Positive %": 4.616, + "Num Positive per mm^2": 408.19 + } +} \ No newline at end of file diff --git a/428/history_text.txt b/428/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..6e58b6e4cd090d1d3354a231709212520da832a7 --- /dev/null +++ b/428/history_text.txt @@ -0,0 +1 @@ +History of multiple ablation of a carcinoma in the area of the left vocal fold. The last biopsy <2018> revealed a G3 differentiated squamous cell carcinoma in a biopsy of the left anterior vocal fold. Due to the lack of exposure of the anterior commissure, there is now an indication for a partial laryngectomy from the outside. The patient had ample opportunity to ask questions about the procedure before the operation. As part of the preoperative CT scan, cT1 cN0 glottic carcinoma on the left. Additional findings: cerebellar mass. This still needs to be clarified by magnetic resonance imaging in the interval. \ No newline at end of file diff --git a/428/icd_codes.txt b/428/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..31f58876b28caf6583e662fc242ecb509734f250 --- /dev/null +++ b/428/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Glottis[C32.0 L] \ No newline at end of file diff --git a/428/ops_codes.txt b/428/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..86fc6fa6aad468eb209c1bd680b2e64837e05747 --- /dev/null +++ b/428/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Chordektomie durch Thyreotomie[5-302.2 ] \ No newline at end of file diff --git a/428/patient_clinical_data.json b/428/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..22faa15a0d2ec74dd2967e9a3fbfe7432ee80bc2 --- /dev/null +++ b/428/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2018, + "age_at_initial_diagnosis": 60, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 141, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/428/patient_pathological_data.json b/428/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..a7aa219073897a32c95ef394b8d80e20c393299f --- /dev/null +++ b/428/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "428", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1a", + "pN_stage": "NX", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/428/surgery_description.txt b/428/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..a09e8ebdd223a459d85cfbae22554e663b3f325d --- /dev/null +++ b/428/surgery_description.txt @@ -0,0 +1 @@ +Chordectomy through thyreofissure diff --git a/428/surgery_report.txt b/428/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3e77897e5e2e204cd9959ef52c6716e02e3911b4 --- /dev/null +++ b/428/surgery_report.txt @@ -0,0 +1 @@ +After active patient identification, the patient is brought into the operating theater. Carrying out the team time-out. Introductory consultation with the anesthesia colleagues. Induction of anesthesia and intubation of the patient. Positioning of the patient by the surgeon. Insertion of the mouthguard. Insertion of the size D Kleinsasser tube. First, adjustment of the endolarynx. A scar is visible in the area of the left anterior third of the vocal fold. The anterior commissure is extremely difficult to adjust. Using the O° view, a slightly uneven area of mucosa can be seen in the area of the anterior vocal fold with a transition to the anterior commissure. Endolaryngeal laser resection does not appear to be a sensible option. Therefore, as discussed with the patient in advance, remove the Kleinsasser tube and proceed to chordectomy via a thyrofissure. First reposition the patient. Skin spray disinfection and infiltration anesthesia. Abjoration of the surgical site and sterile draping. Clear identification of the thyroid incissure and the level of the cricoid cartilage. Marking of the planned incision using the broken line technique. Sharp cutting of the cutis as well as the subcutis. Insertion of the sharp retractor. Exposure of the prelaryngeal musculature. Separation of the same in the area of the linea alba. Exposure of the thyroid cartilage. Incision of the perichondrium in the median line and formation of 2 perichondrium lobes. Horizontal incision in the area of the ligamentum conicum. Open the thyroid cartilage strictly in the median line using the wheel. Insertion of the 2-pronged retractor and meticulous inspection of the endolaryngeal findings. This shows the previously detected endoscopically unstable mucosal area in the area of the left anterior third of the vocal fold with transition to the anterior commissure. The 15 mm scalpel is now used to make a circular incision around the mass with an appropriate safety margin. Part of the perichondrium in the area of the anterior commissure is also resected. The specimen is thread-marked and sent for definitive histological processing. In addition, 4 marginal samples are taken (upper left vocal fold, lower left vocal fold, anterior commissure and right anterior commissure). All frozen sections were found to be tumor-free intraoperatively. There was also no evidence of CIS. Since all marginal specimens show the tumor area in a circular fashion, an R0 resection can be assumed. Grinding of the inner cortex in the area of the former left anterior third of the vocal fold. The remaining thyroarytaenoid muscle is preserved. Wound irrigation with H202 and Ringer's solution. Creation of a total of 4 drill holes. Closure of the laryngeal skeleton with PDS 4.0. Closure of the incision in the area of the ligamentum conicum. Suturing of the previously prepared perichondrium leaves. Readaptation of the prelaryngeal musculature. A second layer of prelaryngeal musculature is also stitched laterally over the median line to create a corresponding counterpressure. Finally, insertion of a flap, subcutaneous suture with Vicryl 4-0 and skin suture with Ethilon 5-0. Application of a wound dressing and completion of the operation without complications. Conclusion: This resulted in a chordectomy via a thyrofissure. Intraoperative R0. Preoperative computed tomography findings also cT1c N0. Due to the preoperative sonographic findings in the neck, please monitor closely and present the patient to the tumor conference as standard. With regard to the cerebellar mass, please undergo further magnetic resonance imaging during the inpatient stay. \ No newline at end of file diff --git a/429/InvasionFront_CD3_block18_x1_y9_patient429_0.json b/429/InvasionFront_CD3_block18_x1_y9_patient429_0.json new file mode 100644 index 0000000000000000000000000000000000000000..05a94dc548dc8fa6c67cb842c4971046469fc047 --- /dev/null +++ b/429/InvasionFront_CD3_block18_x1_y9_patient429_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 27035.7, + "Num Detections": 15751, + "Num Negative": 14980, + "Num Positive": 771, + "Positive %": 4.895, + "Num Positive per mm^2": 448.79 + } +} \ No newline at end of file diff --git a/429/InvasionFront_CD3_block18_x2_y9_patient429_1.json b/429/InvasionFront_CD3_block18_x2_y9_patient429_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9d4bbe226b5622fbf544c1a9111a75bd2184d45b --- /dev/null +++ b/429/InvasionFront_CD3_block18_x2_y9_patient429_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6071.8, + "Centroid Y µm": 27135.6, + "Num Detections": 17136, + "Num Negative": 16395, + "Num Positive": 741, + "Positive %": 4.324, + "Num Positive per mm^2": 365.48 + } +} \ No newline at end of file diff --git a/429/InvasionFront_CD8_block18_x1_y9_patient429_0.json b/429/InvasionFront_CD8_block18_x1_y9_patient429_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3a09335da16ce6aac954bcc94587ff409e75678d --- /dev/null +++ b/429/InvasionFront_CD8_block18_x1_y9_patient429_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3997.9, + "Centroid Y µm": 29934.2, + "Num Detections": 19083, + "Num Negative": 18783, + "Num Positive": 300, + "Positive %": 1.572, + "Num Positive per mm^2": 147.38 + } +} \ No newline at end of file diff --git a/429/InvasionFront_CD8_block18_x2_y9_patient429_1.json b/429/InvasionFront_CD8_block18_x2_y9_patient429_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5544e0d2f52a49444ed6b7f4231c388e481e1d94 --- /dev/null +++ b/429/InvasionFront_CD8_block18_x2_y9_patient429_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6621.5, + "Centroid Y µm": 29984.1, + "Num Detections": 18944, + "Num Negative": 18398, + "Num Positive": 546, + "Positive %": 2.882, + "Num Positive per mm^2": 245.39 + } +} \ No newline at end of file diff --git a/429/TumorCenter_CD3_block18_x1_y9_patient429_0.json b/429/TumorCenter_CD3_block18_x1_y9_patient429_0.json new file mode 100644 index 0000000000000000000000000000000000000000..93560e7b8fabbd71adc08725ccb3ff66542f9c93 --- /dev/null +++ b/429/TumorCenter_CD3_block18_x1_y9_patient429_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3323.2, + "Centroid Y µm": 21613.6, + "Num Detections": 17290, + "Num Negative": 17179, + "Num Positive": 111, + "Positive %": 0.642, + "Num Positive per mm^2": 49.42 + } +} \ No newline at end of file diff --git a/429/TumorCenter_CD3_block18_x2_y9_patient429_1.json b/429/TumorCenter_CD3_block18_x2_y9_patient429_1.json new file mode 100644 index 0000000000000000000000000000000000000000..018d7848493a82ff0886588eac5dfde3472c75dc --- /dev/null +++ b/429/TumorCenter_CD3_block18_x2_y9_patient429_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5821.9, + "Centroid Y µm": 21738.5, + "Num Detections": 22298, + "Num Negative": 22067, + "Num Positive": 231, + "Positive %": 1.036, + "Num Positive per mm^2": 92.09 + } +} \ No newline at end of file diff --git a/429/TumorCenter_CD8_block18_x1_y9_patient429_0.json b/429/TumorCenter_CD8_block18_x1_y9_patient429_0.json new file mode 100644 index 0000000000000000000000000000000000000000..1c4edebb6c7170c099d3bd502e054b15b224b3f4 --- /dev/null +++ b/429/TumorCenter_CD8_block18_x1_y9_patient429_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3198.3, + "Centroid Y µm": 22563.1, + "Num Detections": 18721, + "Num Negative": 18549, + "Num Positive": 172, + "Positive %": 0.9188, + "Num Positive per mm^2": 76.8 + } +} \ No newline at end of file diff --git a/429/TumorCenter_CD8_block18_x2_y9_patient429_1.json b/429/TumorCenter_CD8_block18_x2_y9_patient429_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1dcf380e1c313294020ba2c2a6f6a4e23643d997 --- /dev/null +++ b/429/TumorCenter_CD8_block18_x2_y9_patient429_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5796.9, + "Centroid Y µm": 22638.0, + "Num Detections": 22364, + "Num Negative": 22057, + "Num Positive": 307, + "Positive %": 1.373, + "Num Positive per mm^2": 126.26 + } +} \ No newline at end of file diff --git a/429/history_text.txt b/429/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..526bc53fd40cf6540f38115553bb9d4eabd6a03f --- /dev/null +++ b/429/history_text.txt @@ -0,0 +1 @@ +Patient with a histologically confirmed verrucous squamous cell carcinoma in the area of the anterior third of the left vocal fold and the anterior commissure. Thus indication for laryngoscopy to plan further treatment. \ No newline at end of file diff --git a/429/icd_codes.txt b/429/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..15cdf3cedbb267117d620058bfef3b6f5d6fd43f --- /dev/null +++ b/429/icd_codes.txt @@ -0,0 +1 @@ +Glottiskarzinom[C32.0 L] \ No newline at end of file diff --git a/429/ops_codes.txt b/429/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..dff177eb8da18afbce99e9f2df4b59384f52331d --- /dev/null +++ b/429/ops_codes.txt @@ -0,0 +1 @@ +Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] \ No newline at end of file diff --git a/429/patient_clinical_data.json b/429/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..8dadb7318b7dc243b1088667cd22b489b326a76a --- /dev/null +++ b/429/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 69, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 15, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/429/patient_pathological_data.json b/429/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6152d9f60f4add5cca63bd4b51bedb8c03582f63 --- /dev/null +++ b/429/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "429", + "primary_tumor_site": "Larynx", + "pT_stage": "pT1", + "pN_stage": "NX", + "grading": "G2", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": NaN, + "number_of_resected_lymph_nodes": 0, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": null, + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 3.0 +} \ No newline at end of file diff --git a/429/surgery_description.txt b/429/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..ef821388bbccb9e7b46c8c7ee11ccdaefb00967e --- /dev/null +++ b/429/surgery_description.txt @@ -0,0 +1 @@ +Laryngoscopy, Frontolateral laryngeal partial resection diff --git a/429/surgery_report.txt b/429/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e6b1ae346dbe7f793c43f4837c404e54259b1c53 --- /dev/null +++ b/429/surgery_report.txt @@ -0,0 +1 @@ +First, the patient is induced anesthesia and transoral endotracheal intubation using a laser tube by the anesthesia colleagues. Positioning of the patient by the surgeon. First, laryngoscopy is performed and an attempt is made to adjust the findings. Unfortunately, this was not successful. The decision is therefore made to reorganize the findings in the sense of a partial laryngectomy according to Leroux Robert. Skin spray disinfection, application of local anesthesia in a skin fold at the level of the thyroid cartilage. Skin ablation, sterile draping. Creation of an approx. 6 mm long incision in this skin fold. Cut through the subcutaneous tissue and platysma. Formation of a subplatysmal flap cranially and caudally. Exposure and transection of the prelaryngeal musculature in the midline. Undermining and ligation of some branches of the anterior jugular vein. Exposure of the cricothyroid cartilage and the cricoid cartilage. Scalpel incision along the thyroid vein. Separation of the perichondrium from the thyroid cartilage, horizontal incision of the cricothyroid vein using a monopolar needle. Median thyroidectomy using a small wire. Opening of the laryngeal lumen and inspection of the findings. Exophytic mass in the area of the anterior third of the left vocal fold and in the area of the anterior commissure. The findings were incised using scissors and 3 marginal samples were sent for intraoperative frozen section examination (left glottis, left subglottis, anterior commissure). Tiny CIS fragments were found in the left glottis margin specimen by the pathology colleague, thus resection in this region. A resection specimen is taken, which is sent for final histology and a second left glottis margin specimen is taken, which is sent for intraoperative frozen section examination. This time the pathology colleague found it to be tumor-free. Thus hemostasis endolaryngeal. Fitting of a size 16 Keel placeholder after drilling holes in the thyroid cartilage. Adjustment of the perichondrium leaves of the thyroid cartilage in the midline. The prelaryngeal musculature is sutured together in the midline. Creation of a flap, prelaryngeal platysma suture. Single button skin suture. Application of a pressure bandage, completion of the procedure without complications. Please plan control MLE and Keel removal in 6 weeks. The patient received intraoperative Clindamy-cin 600 mg intravenously. Please continue antibiotics 4 x daily for the next 7 days. \ No newline at end of file diff --git a/430/InvasionFront_CD3_block4_x5_y9_patient430_0.json b/430/InvasionFront_CD3_block4_x5_y9_patient430_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8b2cc2a7ebbb681a16525104f5d9d8c4fe7feb28 --- /dev/null +++ b/430/InvasionFront_CD3_block4_x5_y9_patient430_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18740.1, + "Centroid Y µm": 28784.8, + "Num Detections": 17006, + "Num Negative": 16507, + "Num Positive": 499, + "Positive %": 2.934, + "Num Positive per mm^2": 217.66 + } +} \ No newline at end of file diff --git a/430/InvasionFront_CD3_block4_x6_y9_patient430_1.json b/430/InvasionFront_CD3_block4_x6_y9_patient430_1.json new file mode 100644 index 0000000000000000000000000000000000000000..de1d981bb277b6b9fd43dd594578b504cae3ec7a --- /dev/null +++ b/430/InvasionFront_CD3_block4_x6_y9_patient430_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 21338.7, + "Centroid Y µm": 28909.7, + "Num Detections": 15485, + "Num Negative": 14705, + "Num Positive": 780, + "Positive %": 5.037, + "Num Positive per mm^2": 357.74 + } +} \ No newline at end of file diff --git a/430/InvasionFront_CD8_block4_x5_y9_patient430_0.json b/430/InvasionFront_CD8_block4_x5_y9_patient430_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a610b8d22eeb94fc40257b9211987639b1a850d6 --- /dev/null +++ b/430/InvasionFront_CD8_block4_x5_y9_patient430_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16416.3, + "Centroid Y µm": 27510.4, + "Num Detections": 16528, + "Num Negative": 16292, + "Num Positive": 236, + "Positive %": 1.428, + "Num Positive per mm^2": 102.36 + } +} \ No newline at end of file diff --git a/430/InvasionFront_CD8_block4_x6_y9_patient430_1.json b/430/InvasionFront_CD8_block4_x6_y9_patient430_1.json new file mode 100644 index 0000000000000000000000000000000000000000..23435d156335907cc10d4fa64e7b8f63938b13c6 --- /dev/null +++ b/430/InvasionFront_CD8_block4_x6_y9_patient430_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19064.9, + "Centroid Y µm": 27510.4, + "Num Detections": 15731, + "Num Negative": 15193, + "Num Positive": 538, + "Positive %": 3.42, + "Num Positive per mm^2": 238.45 + } +} \ No newline at end of file diff --git a/430/TumorCenter_CD3_block4_x5_y9_patient430_0.json b/430/TumorCenter_CD3_block4_x5_y9_patient430_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b0202abd0f6100f76fdd6664a050f661a0221c65 --- /dev/null +++ b/430/TumorCenter_CD3_block4_x5_y9_patient430_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16216.4, + "Centroid Y µm": 23087.8, + "Num Detections": 14940, + "Num Negative": 14638, + "Num Positive": 302, + "Positive %": 2.021, + "Num Positive per mm^2": 141.76 + } +} \ No newline at end of file diff --git a/430/TumorCenter_CD3_block4_x6_y9_patient430_1.json b/430/TumorCenter_CD3_block4_x6_y9_patient430_1.json new file mode 100644 index 0000000000000000000000000000000000000000..a39dc1daaf127d85b4eb17e6bf8d27801fc03820 --- /dev/null +++ b/430/TumorCenter_CD3_block4_x6_y9_patient430_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 23062.8, + "Num Detections": 11631, + "Num Negative": 11525, + "Num Positive": 106, + "Positive %": 0.9114, + "Num Positive per mm^2": 51.03 + } +} \ No newline at end of file diff --git a/430/TumorCenter_CD8_block4_x5_y9_patient430_0.json b/430/TumorCenter_CD8_block4_x5_y9_patient430_0.json new file mode 100644 index 0000000000000000000000000000000000000000..28375aafea003d25e779a8617157cfeb4650342d --- /dev/null +++ b/430/TumorCenter_CD8_block4_x5_y9_patient430_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16241.4, + "Centroid Y µm": 23287.7, + "Num Detections": 19063, + "Num Negative": 18941, + "Num Positive": 122, + "Positive %": 0.64, + "Num Positive per mm^2": 56.68 + } +} \ No newline at end of file diff --git a/430/TumorCenter_CD8_block4_x6_y9_patient430_1.json b/430/TumorCenter_CD8_block4_x6_y9_patient430_1.json new file mode 100644 index 0000000000000000000000000000000000000000..943979565aeef847abf196ed0308d4a0bc3b0a0d --- /dev/null +++ b/430/TumorCenter_CD8_block4_x6_y9_patient430_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18815.0, + "Centroid Y µm": 23462.6, + "Num Detections": 17694, + "Num Negative": 17561, + "Num Positive": 133, + "Positive %": 0.7517, + "Num Positive per mm^2": 62.91 + } +} \ No newline at end of file diff --git a/430/history_text.txt b/430/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/430/icd_codes.txt b/430/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..45838eac835faac8966753fb0b91b54be81850ff --- /dev/null +++ b/430/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Gaumen und Uvula[C05.8 ] \ No newline at end of file diff --git a/430/ops_codes.txt b/430/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..96706bfd8048968987abe5236b1635bdacd00a12 --- /dev/null +++ b/430/ops_codes.txt @@ -0,0 +1 @@ +Gaumentumorexzision[5-272.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 B] Entnahme freier Radialis-Lappen[5-858.23 L] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Entnahme von Spalthaut des Oberschenkels[5-901.0e R] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/430/patient_clinical_data.json b/430/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..45aa2abae8a09cc145f2131a8b339341e61bda94 --- /dev/null +++ b/430/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 65, + "sex": "female", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/430/patient_pathological_data.json b/430/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d69757300a9becc14310c29d0534a1e502ce0079 --- /dev/null +++ b/430/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "430", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 26, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 7.0 +} \ No newline at end of file diff --git a/430/surgery_description.txt b/430/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..aaf8d7e8cfd0d2eda31f6778ffc5e407c008ea6f --- /dev/null +++ b/430/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Modified radical neck dissection, Free flap (Radial) diff --git a/430/surgery_report.txt b/430/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..5aa3ae336b5765d94da04408edf1b11a84cfa65f --- /dev/null +++ b/430/surgery_report.txt @@ -0,0 +1 @@ +Dictation . Induction of anesthesia and intubation by anesthesia colleagues. Sterile washing and draping. Start of tracheotomy: vertical skin incision for this. Dissection through the subcutaneous fatty tissue. Exposure of the linea alba. Push the muscles to the side. Exposure of the thyroid isthmus. Undermining of the thyroid isthmus and coagulation and transection of the thyroid isthmus. Exposure of the anterior tracheal wall and entry into the trachea between the 1st and 2nd tracheal cartilage. Creation of a visor tracheotomy. Creation of a mucocutaneous anastomosis. Repositioning of the patient, sterile washing and draping. Insertion of the mouth blocker. Inspection of the tumor. The tumor covers the entire soft palate median and paramedian on the right. The tumor is incised with the monopolar needle with a safety margin of 1 - 1.5 cm. Detachment of the tumor from the soft palate and from the anterior and posterior palatal arch, which must be partially resected on both sides. Measure the defect: 7.5 x 6 cm. Parallel neck dissection on both sides and lifting of the radialis graft. Neck dissection on the right side. Skin incision in the usual manner on the anterior border of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland. Exposure of the cervical vascular sheath and detachment of the neck preparation II a to V a while preserving the plexus branches. Exposure of the vessels. Exposure of the superior thyroid artery, external artery and external jugular vein and facial vein, which will also be used later for the connection. Neck dissection on the left side. Skin incision also on the front edge of the sternocleidomastoid muscle. Exposure of the sternocleidomastoid muscle, the submandibular gland, the omohyoid muscle and the digastric muscle. Exposure of the cervical vascular sheath and release of the neck preparation II a to V a while sparing the plexus branches. Insertion of a Redon drain and two-layer wound closure. On the left side, the submandibular gland is removed and the digastric muscle is cut to create a breakthrough to the enoral side, where the stalk can later be removed. Sending the tumor to pathology. The frozen section revealed carcinoma in situ on the left side at the anterior edge of the soft palate and at the posterior edge. A large resection was taken at both sites and another margin sample was taken. The final margin samples were free of tumor and carcinoma in situ. Radialis graft elevation : Elevation of the radialis graft on the distal left forearm. Drawing of a radialis graft on the distal forearm with a size of 8 x 6 cm. Extending S-shaped skin incision to the proximal forearm in the crook of the elbow to the proximal forearm in the crook of the elbow. Separation of the cutaneous and subcutaneous tissue. Dissection of the deep forearm fascia. Identification of the confluence of the superficial and deep venous system. Identification of the cephalic vein. Ulnar skin incision in the area of the radialis graft and subfascial dissection up to the anterior edge of the flexor carpi radialis muscle. Radial skin preparation on the deep forearm fascia. Identification of the radial nerve (external ramus). Sharp dissection of the subfascial nerve. Particular care is taken to leave sufficient tissue on the tendon of the brachioradialis muscle. Identification of the distal part of the radial artery. Provisional clamping with a vascular clamp. Wait 10 minutes, during which time a good perfusion signal is recorded in the area of the index finger. Separation of the distal radial artery with the comitant veins and ligation. Elevation of the radial artery graft from the depths with constant bipolar coagulation of smaller vessels and placement of several vascular clips. This was successful without any problems. Completion of flap elevation without complications. Deposition of the flap by . Wound closure using split skin from the right thigh in the usual manner by and . Incision of the graft: First, the back surface of the soft palate is fixed with three sutures. Folding and folding of the graft and suturing of the front and the tonsil region. The tonsil region is difficult to suture due to swelling of the tongue and small mouth opening. Ultimately, the flap can be sutured in completely and the stalk can be diverted to the right. Start with the anastomosis. The radial artery is connected to the superior thyroid artery. However, a problem then arises in that there is no venous return flow from the dissected veins. It is determined that the confluence between the upper and deeper venous system is insufficient in this radial artery graft. The entire upper venous system is therefore clamped off and the concomitant vein is used for connection. This shows very good reflux in both concomitant veins. Therefore, one is anastomosed end-to-side to the external vein and the second end-to-end to a branch of the facial vein using the coupler. Insertion of a flap and two-layer wound closure. The patient is ventilated and admitted to the intensive care unit. Please continue antibiotics for at least 24 hours. Flap and wound checks. At the end, a tracheostomy tube was inserted and fixed with a suture. Cannula change on the 5th postoperative day and then suturing again, as the vein situation is very critical and a cannula tape must not be passed over the neck for 10 days under any circumstances. \ No newline at end of file diff --git a/431/InvasionFront_CD3_block18_x1_y8_patient431_0.json b/431/InvasionFront_CD3_block18_x1_y8_patient431_0.json new file mode 100644 index 0000000000000000000000000000000000000000..24fde139b82f8a1f041b4f65c3512bfe99bf6351 --- /dev/null +++ b/431/InvasionFront_CD3_block18_x1_y8_patient431_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3648.1, + "Centroid Y µm": 24012.3, + "Num Detections": 9459, + "Num Negative": 9169, + "Num Positive": 290, + "Positive %": 3.066, + "Num Positive per mm^2": 250.26 + } +} \ No newline at end of file diff --git a/431/InvasionFront_CD3_block18_x2_y8_patient431_1.json b/431/InvasionFront_CD3_block18_x2_y8_patient431_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f70c76c0c98e6cf94868bf5ae5265dab4321489 --- /dev/null +++ b/431/InvasionFront_CD3_block18_x2_y8_patient431_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 24437.1, + "Num Detections": 9371, + "Num Negative": 9063, + "Num Positive": 308, + "Positive %": 3.287, + "Num Positive per mm^2": 282.77 + } +} \ No newline at end of file diff --git a/431/InvasionFront_CD8_block18_x1_y8_patient431_0.json b/431/InvasionFront_CD8_block18_x1_y8_patient431_0.json new file mode 100644 index 0000000000000000000000000000000000000000..6971894622749b849c72605457613bfafde4fb8a --- /dev/null +++ b/431/InvasionFront_CD8_block18_x1_y8_patient431_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4230.7, + "Centroid Y µm": 27628.8, + "Num Detections": 12179, + "Num Negative": 11911, + "Num Positive": 268, + "Positive %": 2.201, + "Num Positive per mm^2": 175.5 + } +} \ No newline at end of file diff --git a/431/InvasionFront_CD8_block18_x2_y8_patient431_1.json b/431/InvasionFront_CD8_block18_x2_y8_patient431_1.json new file mode 100644 index 0000000000000000000000000000000000000000..895d104c9c6d638621067e2e55c99499692de900 --- /dev/null +++ b/431/InvasionFront_CD8_block18_x2_y8_patient431_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6659.0, + "Centroid Y µm": 27560.4, + "Num Detections": 12638, + "Num Negative": 12304, + "Num Positive": 334, + "Positive %": 2.643, + "Num Positive per mm^2": 212.29 + } +} \ No newline at end of file diff --git a/431/TumorCenter_CD3_block18_x1_y8_patient431_0.json b/431/TumorCenter_CD3_block18_x1_y8_patient431_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b8868978c38d2325049528e78685e47ce29af471 --- /dev/null +++ b/431/TumorCenter_CD3_block18_x1_y8_patient431_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3427.3, + "Centroid Y µm": 19219.2, + "Num Detections": 13630, + "Num Negative": 13443, + "Num Positive": 187, + "Positive %": 1.372, + "Num Positive per mm^2": 111.2 + } +} \ No newline at end of file diff --git a/431/TumorCenter_CD3_block18_x2_y8_patient431_1.json b/431/TumorCenter_CD3_block18_x2_y8_patient431_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3269b50fef590c0f550357bc4043b9f08d6c6118 --- /dev/null +++ b/431/TumorCenter_CD3_block18_x2_y8_patient431_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5896.8, + "Centroid Y µm": 19339.8, + "Num Detections": 17119, + "Num Negative": 16615, + "Num Positive": 504, + "Positive %": 2.944, + "Num Positive per mm^2": 253.81 + } +} \ No newline at end of file diff --git a/431/TumorCenter_CD8_block18_x1_y8_patient431_0.json b/431/TumorCenter_CD8_block18_x1_y8_patient431_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f7b1318a0adc0e757d666db837732e3a16422934 --- /dev/null +++ b/431/TumorCenter_CD8_block18_x1_y8_patient431_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3423.2, + "Centroid Y µm": 20164.3, + "Num Detections": 13654, + "Num Negative": 13314, + "Num Positive": 340, + "Positive %": 2.49, + "Num Positive per mm^2": 204.46 + } +} \ No newline at end of file diff --git a/431/TumorCenter_CD8_block18_x2_y8_patient431_1.json b/431/TumorCenter_CD8_block18_x2_y8_patient431_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d2bd953c40168341b193942d06384188b3879ac9 --- /dev/null +++ b/431/TumorCenter_CD8_block18_x2_y8_patient431_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5747.0, + "Centroid Y µm": 20164.3, + "Num Detections": 17283, + "Num Negative": 16697, + "Num Positive": 586, + "Positive %": 3.391, + "Num Positive per mm^2": 298.41 + } +} \ No newline at end of file diff --git a/431/history_text.txt b/431/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/431/icd_codes.txt b/431/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5eea551dcba0de87a8ec6b05ace93f795f5f9a5e --- /dev/null +++ b/431/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung der Subglottis[C32.2 L] \ No newline at end of file diff --git a/431/ops_codes.txt b/431/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..967487141fed230e08ce2a321281e559c98a62cf --- /dev/null +++ b/431/ops_codes.txt @@ -0,0 +1 @@ +Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] \ No newline at end of file diff --git a/431/patient_clinical_data.json b/431/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4df1e064f00cce28e23c94f7bd76448e6490bb85 --- /dev/null +++ b/431/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 9, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "no", + "adjuvant_radiotherapy_modality": null, + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/431/patient_pathological_data.json b/431/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..d114e690f7158e114061f5b1cd1961ddfb95beba --- /dev/null +++ b/431/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "431", + "primary_tumor_site": "Larynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 5, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 11.0 +} \ No newline at end of file diff --git a/431/surgery_description.txt b/431/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..017c0bb9a27705bc3496debc444cb44865813cb1 --- /dev/null +++ b/431/surgery_description.txt @@ -0,0 +1 @@ +Total laryngectomy, Selective bilateral neck dissection, Provox diff --git a/431/surgery_report.txt b/431/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..3f911765519aa204fb6029cba7739b7ec3361950 --- /dev/null +++ b/431/surgery_report.txt @@ -0,0 +1 @@ +Introductory consultation with the anesthesia department. After appropriate preparation, skin disinfection and sterile washing. Marking and incision of the apron flap. Dissection cranially up to above the hyoid bone. Then perform the neck dissection on the right side. Skeletonization of the sternocleidomastoid muscle and displacement, neurolysis and re-embedding of the accessorius and hypoglossal nerves. Subsequently, clearing of regions II to IV with preservation of all non-lymphatic structures and dissection of the internal jugular vein and carotid artery. Subsequent exposure of the lateral hyoid horn and release of the infrahyoid muscles with exposure of the thyrohyoid membrane. Skeletonization of the common carotid artery and external carotid artery with exposure of the superior thyroid artery, along which the right thyroid lobe can also be separated from the laryngeal skeleton and displaced laterally. Cut and separate the straight prelaryngeal and prethyroid muscles. Subsequently undermine the thyroid isthmus down to the pretracheal lamina, clamp the isthmus so that the upper six tracheal clasps are fully exposed. Then sharply separate the insertions of the constrictor pharyngis muscle at the edge of the thyroid cartilage and release the piriform sinus on this side. Then transition to the opposite side. In principle, the procedure is the same here with the same findings. Perform the tracheotomy. Opening of the trachea under the 2nd tracheal clasp. Re-intubation of the patient. This is followed by a total laryngectomy. The lingual surface of the epiglottis is exposed up to the upper edge and the mucosa is only incised at the upper edge of the epiglottis. This allows it to be disluxed and the larynx to be removed along the epiglottis and finally postcricoidally. The protrusion of the left-dorsal tumor in the area of the cricoid cartilage can also be seen here, although it remains covered by intact mucosa or muscle tissue. The larynx is then released together with the two upper tracheal clips. Removal of a marginal sample from the caudal resection margin of the specimen towards the trachea as well as from retrolaryngeal tissue in the area of the tumour location. Both histologies prove to be tumor-free in frozen section diagnostics. The pars membranacea of the trachea is then mobilized so that it can be mobilized cranially to complete the mucocutaneous anastomosis. Perform the voice prosthesis puncture with insertion of a size 8 Provox Vega voice prosthesis at the upper edge of the tracheostoma. Perform a myotomy of the constrictor pharyngis muscle. The pharyngeal suture is then applied. The first layer forms a continuous Conley suture. An additional wound closure is made using the single-button technique. Insertion of the Redon suction drains on both sides. Folding back the apron flap. Completion of the mucocutaneous anastomosis of the tracheostoma and double-layered suturing of the lateral wound edges. Finally, easy transfer of the patient to a 10-gauge Rügheimer cannula. Sterile wound dressing. Application of a pressure dressing. Final consultation with the anesthetist. Conclusion: Total laryngectomy with selective neck dissection on both sides. Primary voice rehabilitation by implantation of a Provox Vega 8 mm voice prosthesis with myotomy of the constrictor pharyngis muscle. \ No newline at end of file diff --git a/432/InvasionFront_CD3_block10_x1_y4_patient432_0.json b/432/InvasionFront_CD3_block10_x1_y4_patient432_0.json new file mode 100644 index 0000000000000000000000000000000000000000..2464c825d10afceeb08af8bdad9fa337b740527a --- /dev/null +++ b/432/InvasionFront_CD3_block10_x1_y4_patient432_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 14892.1, + "Num Detections": 22854, + "Num Negative": 20024, + "Num Positive": 2830, + "Positive %": 12.38, + "Num Positive per mm^2": 1089.8 + } +} \ No newline at end of file diff --git a/432/InvasionFront_CD3_block10_x2_y4_patient432_1.json b/432/InvasionFront_CD3_block10_x2_y4_patient432_1.json new file mode 100644 index 0000000000000000000000000000000000000000..03d238c759c4b1ef8574fa1bbc3facf62e4d5939 --- /dev/null +++ b/432/InvasionFront_CD3_block10_x2_y4_patient432_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8770.4, + "Centroid Y µm": 14992.1, + "Num Detections": 22944, + "Num Negative": 20679, + "Num Positive": 2265, + "Positive %": 9.872, + "Num Positive per mm^2": 891.67 + } +} \ No newline at end of file diff --git a/432/InvasionFront_CD8_block10_x1_y4_patient432_0.json b/432/InvasionFront_CD8_block10_x1_y4_patient432_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0c83349314e6daf37c127c484ebef14a9cab8667 --- /dev/null +++ b/432/InvasionFront_CD8_block10_x1_y4_patient432_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 5222.2, + "Centroid Y µm": 15591.7, + "Num Detections": 23682, + "Num Negative": 19724, + "Num Positive": 3958, + "Positive %": 16.71, + "Num Positive per mm^2": 1537.0 + } +} \ No newline at end of file diff --git a/432/InvasionFront_CD8_block10_x2_y4_patient432_1.json b/432/InvasionFront_CD8_block10_x2_y4_patient432_1.json new file mode 100644 index 0000000000000000000000000000000000000000..192ccc9f56eaab58f702af9980fd04ec1f3f2f46 --- /dev/null +++ b/432/InvasionFront_CD8_block10_x2_y4_patient432_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7720.9, + "Centroid Y µm": 15516.8, + "Num Detections": 23911, + "Num Negative": 21230, + "Num Positive": 2681, + "Positive %": 11.21, + "Num Positive per mm^2": 1053.5 + } +} \ No newline at end of file diff --git a/432/TumorCenter_CD3_block10_x1_y4_patient432_0.json b/432/TumorCenter_CD3_block10_x1_y4_patient432_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a106a124fc4fa68463c901185fe5234483fcc236 --- /dev/null +++ b/432/TumorCenter_CD3_block10_x1_y4_patient432_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 10219.6, + "Num Detections": 18597, + "Num Negative": 17786, + "Num Positive": 811, + "Positive %": 4.361, + "Num Positive per mm^2": 433.66 + } +} \ No newline at end of file diff --git a/432/TumorCenter_CD3_block10_x2_y4_patient432_1.json b/432/TumorCenter_CD3_block10_x2_y4_patient432_1.json new file mode 100644 index 0000000000000000000000000000000000000000..dd94b7cf96d92b406f417a8bd63ae5931a5c7de1 --- /dev/null +++ b/432/TumorCenter_CD3_block10_x2_y4_patient432_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8945.3, + "Centroid Y µm": 9994.7, + "Num Detections": 3431, + "Num Negative": 3093, + "Num Positive": 338, + "Positive %": 9.851, + "Num Positive per mm^2": 932.63 + } +} \ No newline at end of file diff --git a/432/TumorCenter_CD8_block10_x1_y4_patient432_0.json b/432/TumorCenter_CD8_block10_x1_y4_patient432_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7563fa89ca95b2c2dd1361f3a5d14e22c5aa3c4c --- /dev/null +++ b/432/TumorCenter_CD8_block10_x1_y4_patient432_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3623.1, + "Centroid Y µm": 10944.2, + "Num Detections": 27360, + "Num Negative": 24942, + "Num Positive": 2418, + "Positive %": 8.838, + "Num Positive per mm^2": 907.8 + } +} \ No newline at end of file diff --git a/432/TumorCenter_CD8_block10_x2_y4_patient432_1.json b/432/TumorCenter_CD8_block10_x2_y4_patient432_1.json new file mode 100644 index 0000000000000000000000000000000000000000..8f99e253c31876288c8af46f772fa2479960e28f --- /dev/null +++ b/432/TumorCenter_CD8_block10_x2_y4_patient432_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6096.8, + "Centroid Y µm": 10744.3, + "Num Detections": 14711, + "Num Negative": 11221, + "Num Positive": 3490, + "Positive %": 23.72, + "Num Positive per mm^2": 2170.9 + } +} \ No newline at end of file diff --git a/432/history_text.txt b/432/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3ea0ddb1083cd8272438ded59c9b19491ca6bc74 --- /dev/null +++ b/432/history_text.txt @@ -0,0 +1 @@ +In the patient <2013>, a cT3 cN1 G3 oropharyngeal carcinoma of the posterior pharyngeal wall was histologically confirmed during a panendoscopy. Extension into the nasopharynx, just leaving out the tubal bulges. In addition, an isolated metastasis was found near the retropharyngeal tumor. In our interdisciplinary tumor conference, primary surgical treatment was recommended. \ No newline at end of file diff --git a/432/icd_codes.txt b/432/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/432/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/432/ops_codes.txt b/432/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..a8b348fe79f412f48a450888e973340b60aee6f5 --- /dev/null +++ b/432/ops_codes.txt @@ -0,0 +1 @@ +mikrovaskulär-anastomosierten Transplantat[5-296.24 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Oberschenkel und Knie[5-858.48 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] \ No newline at end of file diff --git a/432/patient_clinical_data.json b/432/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..cb84feb67c19f116118c5e39d750cbe1307e217a --- /dev/null +++ b/432/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 72, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 33, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/432/patient_pathological_data.json b/432/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..784e2390f24d9158f7a351ef84b39b9903a2315e --- /dev/null +++ b/432/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "432", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 39, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": 17.0 +} \ No newline at end of file diff --git a/432/surgery_description.txt b/432/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e1b917654fc1a84e268c8abbd1b285dfdc61e180 --- /dev/null +++ b/432/surgery_description.txt @@ -0,0 +1 @@ +Pharyngectomy, Neck dissection, Pedicled flap (ALT) diff --git a/432/surgery_report.txt b/432/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..66032750e7e2d1918167d222b178f943cd0640c8 --- /dev/null +++ b/432/surgery_report.txt @@ -0,0 +1 @@ +First, after preparation and intubation by the anesthesia colleagues, inspection of the primary tumor region by palpation and with the small bore tube. The largely submucosal, tumorous mass can be seen in the area of the posterior pharyngeal wall, directly adjacent to the retropharyngeal metastasis, which is now clearly progressive compared to CT imaging. Cranially, exophytic, exulcerated tumor part, palpatory just not reaching the tubal bulges. The tumor grows caudally to the border of the oropharynx and hypopharynx and takes up the entire width of the posterior wall of the oropharynx up to the lateral wall. Plastic tracheotomy is now performed for better exposure due to the extensive tumor. To do this, enter at the level of the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Dissection of the thyroid isthmus and, after exposure, insertion between the 1st and 2nd tracheal clasps. Performing a visor tracheotomy. Incision in the usual manner and problem-free reintubation, initially on an 8 mm Woodbridge tube, later on an 8 mm low cuff cannula, which is suture-fixed. First turn to the transoral procedure. Perform a left paramedian soft palate split. Good exposure of the nasopharyngeal part of the tumor for this. This ends well in front of the choanae and does not reach the tubal bulges on either side. Cut around the entire tumor. Perform a lateral tonsillectomy on both sides. Isolation of the tumor to the prevertebral fascia. Here the tumor is only moderately displaceable and has a large surface area. Due to the exposure, transition to the transcervical approach. For this purpose, a skin incision is made on the left side at the anterior edge of the sternocleidomastoid muscle with a slightly left paramedian tumor. Cut through skin and subcutaneous tissue. Exposure of the sternocleidomastoid muscle while preserving the auricular nerve. Exposure of the omohyoid muscle, submandibular gland and digastric muscle. Removal of the anterior neck preparation with careful preservation of the superior thyroid artery and the cervical artery. The facial vein is initially preserved, but is later removed during the transcervical procedure, as is the extremely strong occipital artery. Exposure of the accessorius nerve. Free dissection of the internal jugular vein and clearing of level V while carefully preserving the cervical plexus branches. Subsequent resection of the digastric muscle, already directly connected to the enoral side. Widening of the pharyngotomy. Now exposure in depth. The tumor can be resected by removing the pharyngeal musculature. The prevertebral fascia only needs to be detached in a circumscribed manner. In this case, the resection distance is narrow, but macroscopically and palpatorily completely in sano, and there is also no evidence of perforation of the prevertebral fascia. Removal of the tumor now via transcervical. During mobilization, the nasopharnygeal portion is ruptured. For this reason, the tumor is sent in 2 parts ........ and a complete in-sano resection is also macroscopically present in the marginal area. The tumor is now completely imaged with marginal samples. All tumor........., tumor- and dysplasia-free, so that an R0 situation can be assumed. For the exposure of the tumor, the external and internal carotid arteries had to be visualized in a long-distance view. Extensive pharyngotomy. Therefore absolute indication for defect coverage using a free graft. Neck dissection of the right side should be performed first. In principle, the same procedure is used here. Expose the limiting musculature. Removal of the anterior neck preparation and preservation of the cervical artery, the superior thyroid artery and the facial vein. Free preparation of the internal jugular vein. Exposure of the accessorius nerve. Clearing of the accessorius triangle and level V with careful protection of the nerves. No evidence of lymphatic leakage and dry wound conditions. Finally, exploration and cranial dissection of the external and internal carotid artery, in case of metastatic contact with the internal carotid artery on CT. This is completely explored. No further metastasis or tumor parts, so that the metastasis is also resected in toto. The defect is now measured. Decision to lift an anterolateral thigh graft from the right thigh. For this purpose, after doppler sonographic identification of 3 skin perforators, marking of a graft measuring 11 x 6 cm in total. Medial incision. Cut through skin and subcutaneous tissue. Cutting through the fascia lata. Exposing and securing the rectus femoris muscle. Strictly subfascial dissection. Exposure of the pedicle vessel. Performing the extension incision. Complete resection of the graft. A musculocutaneous perforator course is visible, therefore a narrow muscle cuff is included. Isolation on the vascular pedicle and placement of the vital graft in the area of the pedicle vessels. Careful hemostasis and, if the wound is dry, insertion of a 10-gauge Redon drain and careful, multi-layer wound closure. Subsequently, combined transoral and transcervical insertion of the graft. Here, the suturing conditions were considerably more difficult and laborious. Finally, however, intact and tight conditions on all sides both cervically on both sides and nasopharyngeally. Suturing of the temporary soft palate cleft. Subsequent left-sided cervical pedicle positioning. First conditioning of the occipital artery. This shows extensive vascular damage to the intima. Further conditioning of the facial artery. Damage here too, but better conditions. Several suture attempts with 8-0 Ethilon are initially frustrating here, however, with rapid cessation of venous return flow. Subsequent conditioning of the submental artery. After suturing the artery, a sufficient circulation with proper flap vitality is now achieved, so that in vital conditions, after positioning the pedicle on both sides, the wound is irrigated and, in dry wound conditions, a 10 Redon drain is inserted and the wound is carefully closed. Conclusion: Intraoperative R0-resected, extensive cT3 cN1 to 2a oropharyngeal carcinoma of the posterior pharyngeal wall with extension into the nasopharynx and hypopharynx. Extensive retropharyngeal metastasis adjacent to the tumor. The patient received intraoperative intravenous antibiotics with Sobelin 600 mg, which should be continued for 24 hours postoperatively. If the graft heals properly, a gradual increase in diet is possible from the 8th postoperative day. However, due to the extensive resection, a protracted recovery of the swallowing function is to be expected. \ No newline at end of file diff --git a/433/InvasionFront_CD3_block11_x3_y4_patient433_0.json b/433/InvasionFront_CD3_block11_x3_y4_patient433_0.json new file mode 100644 index 0000000000000000000000000000000000000000..892b467d425503af5f9d5a02439c2efceeb4c26f --- /dev/null +++ b/433/InvasionFront_CD3_block11_x3_y4_patient433_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10469.5, + "Centroid Y µm": 9619.9, + "Num Detections": 7626, + "Num Negative": 7432, + "Num Positive": 194, + "Positive %": 2.544, + "Num Positive per mm^2": 246.7 + } +} \ No newline at end of file diff --git a/433/InvasionFront_CD3_block11_x4_y4_patient433_1.json b/433/InvasionFront_CD3_block11_x4_y4_patient433_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9670c59303cd29d1a288abefdfc1b0ee2b41299c --- /dev/null +++ b/433/InvasionFront_CD3_block11_x4_y4_patient433_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12968.1, + "Centroid Y µm": 9544.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/433/InvasionFront_CD8_block11_x3_y4_patient433_0.json b/433/InvasionFront_CD8_block11_x3_y4_patient433_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ec118b9260f783abfe21717720d0ce03781c6200 --- /dev/null +++ b/433/InvasionFront_CD8_block11_x3_y4_patient433_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13662.9, + "Centroid Y µm": 20386.8, + "Num Detections": 3774, + "Num Negative": 3744, + "Num Positive": 30, + "Positive %": 0.7949, + "Num Positive per mm^2": 87.97 + } +} \ No newline at end of file diff --git a/433/InvasionFront_CD8_block11_x4_y4_patient433_1.json b/433/InvasionFront_CD8_block11_x4_y4_patient433_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d40f953b47704a9589264da09374b1968c397b64 --- /dev/null +++ b/433/InvasionFront_CD8_block11_x4_y4_patient433_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16278.7, + "Centroid Y µm": 20386.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/433/TumorCenter_CD3_block11_x3_y4_patient433_0.json b/433/TumorCenter_CD3_block11_x3_y4_patient433_0.json new file mode 100644 index 0000000000000000000000000000000000000000..144ff4dcefdf34c5572a29119562d5e63a78508c --- /dev/null +++ b/433/TumorCenter_CD3_block11_x3_y4_patient433_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14467.3, + "Centroid Y µm": 9844.8, + "Num Detections": 22976, + "Num Negative": 22111, + "Num Positive": 865, + "Positive %": 3.765, + "Num Positive per mm^2": 422.53 + } +} \ No newline at end of file diff --git a/433/TumorCenter_CD3_block11_x4_y4_patient433_1.json b/433/TumorCenter_CD3_block11_x4_y4_patient433_1.json new file mode 100644 index 0000000000000000000000000000000000000000..01902f5d967d1d77d1e88c025d4170d935af4b3d --- /dev/null +++ b/433/TumorCenter_CD3_block11_x4_y4_patient433_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17016.0, + "Centroid Y µm": 10019.7, + "Num Detections": 26987, + "Num Negative": 26240, + "Num Positive": 747, + "Positive %": 2.768, + "Num Positive per mm^2": 281.85 + } +} \ No newline at end of file diff --git a/433/TumorCenter_CD8_block11_x3_y4_patient433_0.json b/433/TumorCenter_CD8_block11_x3_y4_patient433_0.json new file mode 100644 index 0000000000000000000000000000000000000000..daf3770bbaff469befe090d3c3a2e1c6e416f653 --- /dev/null +++ b/433/TumorCenter_CD8_block11_x3_y4_patient433_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11918.7, + "Centroid Y µm": 9919.7, + "Num Detections": 24266, + "Num Negative": 23799, + "Num Positive": 467, + "Positive %": 1.925, + "Num Positive per mm^2": 215.57 + } +} \ No newline at end of file diff --git a/433/TumorCenter_CD8_block11_x4_y4_patient433_1.json b/433/TumorCenter_CD8_block11_x4_y4_patient433_1.json new file mode 100644 index 0000000000000000000000000000000000000000..7139bc49a8643191708915c6be7ae6b06e52c905 --- /dev/null +++ b/433/TumorCenter_CD8_block11_x4_y4_patient433_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14467.3, + "Centroid Y µm": 9969.7, + "Num Detections": 28017, + "Num Negative": 27453, + "Num Positive": 564, + "Positive %": 2.013, + "Num Positive per mm^2": 209.11 + } +} \ No newline at end of file diff --git a/433/history_text.txt b/433/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/433/icd_codes.txt b/433/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/433/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/433/ops_codes.txt b/433/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..0b8e4a446385430ed45ac01d75920a1579dd784c --- /dev/null +++ b/433/ops_codes.txt @@ -0,0 +1 @@ +Transplantat[5-295.04 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 L] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ] Transplantation sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.93 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] \ No newline at end of file diff --git a/433/patient_clinical_data.json b/433/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..7ac7fdc95324158004f23fea9d6129277b45ce68 --- /dev/null +++ b/433/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2011, + "age_at_initial_diagnosis": 47, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 24, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/433/patient_pathological_data.json b/433/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..9a6a45a6ed109023d3e3106c7fbfb7a5f7511c10 --- /dev/null +++ b/433/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "433", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 59, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 4.0 +} \ No newline at end of file diff --git a/433/surgery_description.txt b/433/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..e32b1d032521236cade6cf441f225c5c557a2ed1 --- /dev/null +++ b/433/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, PEG placement, Modified radical neck dissection (Level II-V bilaterally), Plastic tracheotomy, Defect coverage (Radial flap) diff --git a/433/surgery_report.txt b/433/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..610004cd384fceb9d69a4d7aab5cbfbfe008b78e --- /dev/null +++ b/433/surgery_report.txt @@ -0,0 +1 @@ +Initially start with PEG insertion: For this purpose, insertion with the flexible gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. If diaphanoscopy is very good, regular puncture of the stomach and insertion of the PEG using the usual thread pull-through method. This is successful without any problems. Inconspicuous esophageal mucosa on reflection. Now insertion of the tonsil plug and inspection of the primary tumor region. Previously, palpation revealed a circumscribed induration of the right base of the tongue, but no more extensive infiltration. Inspection now revealed an exulcerated mass in the right tonsil region. From this exophytic mass, extensive erythroplakic changes extend towards the hard palate and parauvularly on the right, also in the area of the upper and lower alveolar ridge; in addition, extensions over the glossotonsillar groove towards the base of the tongue. In the area of the base of the tongue, there were renewed restless, exophytic changes, but not deeper on palpation. The tumor is now resected, partly monopolar, partly using the dissection technique. Left parauvular incision, taking the entire right-sided soft palate as far as the hard palate. Resection alveolar above, hard to the molars. Resection down to the alveolar ridge. Resection of the glossotonsillar groove and superficial resection of a good 1/3 of the base of the tongue. Removal of the tonsil region up to the transition to the posterior pharyngeal wall. Tumor extension towards the posterior pharyngeal wall is not visible. The specimen is completely thread-marked for frozen section diagnostics. CIS in the area of the hard palate towards the alveolar ridge and buccal direction as well as CIS in the parauvular area in the area of the soft palate with otherwise free tumor margins and free basal margins are now visible. Post-resections are now performed in the respective areas, which are again marked with sutures for frozen section diagnostics. This again reveals CIS in the area of the alveolar ridge. Now perform another generous resection from the upper alveolar ridge over the entire buccal length to the lower alveolar ridge. A marginal sample is then taken over the same length, which is again marked with a suture for frozen section diagnostics and this time is assessed as tumor-free. Parallel to the tumor resection, a waisted graft measuring 13 x 6 cm is measured. Parallel procedure for neck dissection and tracheotomy: First tracheotomy. Horizontal skin incision below the cricoid cartilage. Cut through the subcutaneous tissue. Exposure of the infrahyoid musculature. Cut through. Exposure of the cricoid cartilage and the anterior surface of the trachea. Exposure of the thyroid isthmus. Dissection and clamping and transection of the thyroid isthmus. Further exposure of the anterior surface of the trachea. Insertion between the 2nd and 3rd tracheal ring. Creation of a Björk flap with a broad-based stalk and suturing of the mucocutaneous anastomosis. Subsequent easy transfer to a tracheal tube. Then turn to neck dissection on the right: This is a condition following an unclear neck operation. Curved skin incision on the anterior edge of the sternocleidomastoid muscle. Pronounced scarring in the area of the previous operation. An external jugular vein can no longer be visualized here. Dissection of the subcutis and the platysma. Exposure of the sternocleidomastoid muscle. If there is significant cranial scarring, it is difficult to expose the accessorius nerve. Exposure of the omohyoid and digastric muscles. Free preparation and exposure of the internal jugular vein with cervical vein. A very strong facial vein can be seen, which is preserved. Exposure of the submandibular gland. Exposure of the superior thyroid artery and hypoglossal nerve. Now careful clearing of the accessory triangle. Exposure of the common carotid artery and vagus nerve and careful evacuation of level Vb while carefully preserving the plexus branches. All the structures mentioned were preserved during this procedure. Macroscopically, no suspicious lymph nodes were found. Later, the submandibular gland was extirpated. For this purpose, the gland is peeled out subcapsularly while carefully preserving the branch of the mouth. Detachment of the uncinate process and removal after transection of the duct. Now perform a partly blunt, partly preparatory pharyngotomy, approx. 2 transverse fingers wide. This is successful due to the already enoral resection. Now to lift the radialis graft from the left: After marking the graft, unwrap the arm and apply the tourniquet. Cutting around the graft and skin incision with lifting of a skin monitor. With a 13 cm long graft, relatively short distance between graft and monitor to maintain a largely flexible stem length. Now expose the cephalic vein. Follow and perform the Hayden maneuver and expose the superficial radial nerve ramus. Complete preservation of the nerve. After preservation of the nerve, strictly subfascial dissection and release of the radial portion of the flap. Now elevation further from the ulna. Strictly subfascial dissection. A superficial ulnar route is not visible. Identification and careful protection of the median nerve. Further strictly subfascial dissection with clipping of vessels close to the pedicle. This is successful without any problems. A strong fork between the cephalic vein and the strong cubital branch can be visualized in the antecubital region. After dissection of the pedicle, a clear anastomosis between the deep and superficial venous system can be visualized. Exposure and protection of the interosseous route. Reopening of the tourniquet. Immediate regular, somewhat hyperemic reperfusion of the flap with good perfusion of the skin monitor. Minutious hemostasis using clipping and bipolar coagulation. Now initially warming of the arm and the graft with simultaneous post-resection. Neck dissection is also performed on the left side. To do this, make a curved skin incision from the mastoid over the front edge of the sternocleidomastoid muscle. Cut through the subcutis. Exposure and transection of the platysma. Creation of a platysma flap. An external jugular vein cannot be exposed here. Exposure and sparing of the auricular nerve. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Evacuation of the anterior neck preparation with visualization and preservation of the cervical anus, artery and superior thyroid vein. Palpatory identification of the accessorius nerve. After exposing the cervical artery, expose the internal jugular vein. Free dissection reveals an internal jugular vein, which is double-lumened over a distance of approx. 4 cm. Here, branched inlets and a tear of an internal vessel are circumscribed. Vascular suture with 6.0 prolene. This succeeds without any problems. Further visualization. The internal jugular vein reunites approximately at the level of the hyoid and gives off a short but very strong facial branch anteriorly. Now follow the cervical vein posteriorly. Expose the common carotid artery and the vagus nerve. Protect the structures. Successive evacuation of level V while carefully protecting the plexus branches. Clearing of the accessory triangle after nerve exposure. Exposure and preservation of the accessorius............ Final inspection and, if the wound was dry, insertion of a 10-gauge Redon drain and careful, two-layer wound closure. On the left side, there were macroscopically conspicuous lymph nodes in level IV and V. All these structures could be preserved. The vital graft was then removed and the radial flap was incorporated. For this purpose, traction from transcervical. Successive and relatively laborious incorporation with a strong radialis graft. This is sufficient in length. Finally, good fit, only in the area of the upper alveolar ridge there is an overlapping of the posterior molar by the graft due to the resections close to the mucosa, which cannot be completely prevented despite several attempts at suturing and repositioning. Otherwise good graft fit. Parallel to suturing, full-thickness skin was removed from the groin region on the right. A spindle-shaped graft measuring 14 x 7 cm was harvested for this purpose. Subcutaneous mobilization and, after insertion of a 10 Redon drain, multi-layer wound closure, which was successful under moderate, tension-free conditions. Cleaning of the graft and careful incorporation after two-layer wound closure of the forearm in the area of the lifting defect. If the fit is good, a VAC dressing is then applied. Finally, turn to the vascular anastomosis. Exposure and free preparation of the superior thyroid artery. Slightly more difficult positioning conditions in the area of the vascular pedicle, otherwise problem-free arterial anastomosis with 8.0 Ethilon. With good reflux, preparation of a facial branch equivalent to a vein. After vessel preparation with very good reflux, problem-free venous anastomosis with a size III coupler. This was successful without any problems. Good reflux and regular flap and monitor perfusion. Now vessel positioning to protect against kinking. Careful wound inspection and finally meticulous hemostasis. Insertion of a 10-gauge Redon drain with countersunk suture to protect the vascular pedicle and, after monitor adjustment, successive, careful two-layer wound closure and finally reintubation onto an 8-gauge cannula with inner core, which is sutured in place and the procedure is completed at this point without any indication of complications. Conclusion: After frozen section diagnosis R0-resected cT3 oropharyngeal carcinoma on the right. Postoperatively, please monitor closely and regularly. Please monitor the findings in the area of the upper alveolar ridge. Post-operative X-ray pelvis recommended on the 8th postoperative day. If possible, the cannula should be left in place and sutured for 5 days. \ No newline at end of file diff --git a/434/InvasionFront_CD3_block3_x3_y9_patient434_0.json b/434/InvasionFront_CD3_block3_x3_y9_patient434_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8c0ca3f35df7f041d9b1fc9b96ec8b4fb4f6fed9 --- /dev/null +++ b/434/InvasionFront_CD3_block3_x3_y9_patient434_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11924.8, + "Centroid Y µm": 28314.8, + "Num Detections": 24006, + "Num Negative": 20285, + "Num Positive": 3721, + "Positive %": 15.5, + "Num Positive per mm^2": 1499.6 + } +} \ No newline at end of file diff --git a/434/InvasionFront_CD3_block3_x4_y9_patient434_1.json b/434/InvasionFront_CD3_block3_x4_y9_patient434_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e99b99cee5d1cd3eb119a59033a43e23118fd16d --- /dev/null +++ b/434/InvasionFront_CD3_block3_x4_y9_patient434_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14439.2, + "Centroid Y µm": 28738.4, + "Num Detections": 22595, + "Num Negative": 20009, + "Num Positive": 2586, + "Positive %": 11.45, + "Num Positive per mm^2": 1102.8 + } +} \ No newline at end of file diff --git a/434/InvasionFront_CD8_block3_x3_y8_patient434_0.json b/434/InvasionFront_CD8_block3_x3_y8_patient434_0.json new file mode 100644 index 0000000000000000000000000000000000000000..fdf5c695e2ef3920addcacd4cba72f98536fed55 --- /dev/null +++ b/434/InvasionFront_CD8_block3_x3_y8_patient434_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12332.5, + "Centroid Y µm": 19682.7, + "Num Detections": 6161, + "Num Negative": 6111, + "Num Positive": 50, + "Positive %": 0.8116, + "Num Positive per mm^2": 58.85 + } +} \ No newline at end of file diff --git a/434/InvasionFront_CD8_block3_x4_y8_patient434_1.json b/434/InvasionFront_CD8_block3_x4_y8_patient434_1.json new file mode 100644 index 0000000000000000000000000000000000000000..657a1579345af6358df6139c2a721dc89806c28c --- /dev/null +++ b/434/InvasionFront_CD8_block3_x4_y8_patient434_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15074.0, + "Centroid Y µm": 19761.1, + "Num Detections": 18154, + "Num Negative": 17259, + "Num Positive": 895, + "Positive %": 4.93, + "Num Positive per mm^2": 359.24 + } +} \ No newline at end of file diff --git a/434/TumorCenter_CD3_block3_x3_y8_patient434_0.json b/434/TumorCenter_CD3_block3_x3_y8_patient434_0.json new file mode 100644 index 0000000000000000000000000000000000000000..0c25c930c28e07f72c3d1306792431e36e0fd1b8 --- /dev/null +++ b/434/TumorCenter_CD3_block3_x3_y8_patient434_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10869.2, + "Centroid Y µm": 26236.1, + "Num Detections": 18234, + "Num Negative": 18020, + "Num Positive": 214, + "Positive %": 1.174, + "Num Positive per mm^2": 107.75 + } +} \ No newline at end of file diff --git a/434/TumorCenter_CD3_block3_x4_y8_patient434_1.json b/434/TumorCenter_CD3_block3_x4_y8_patient434_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ac8320ace620657ff5233ac7a460ea5d8686554e --- /dev/null +++ b/434/TumorCenter_CD3_block3_x4_y8_patient434_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13482.9, + "Centroid Y µm": 26265.1, + "Num Detections": 23882, + "Num Negative": 19492, + "Num Positive": 4390, + "Positive %": 18.38, + "Num Positive per mm^2": 1838.5 + } +} \ No newline at end of file diff --git a/434/TumorCenter_CD8_block3_x3_y8_patient434_0.json b/434/TumorCenter_CD8_block3_x3_y8_patient434_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c2fab40f3033a457dfc71d523bf407468205bca4 --- /dev/null +++ b/434/TumorCenter_CD8_block3_x3_y8_patient434_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11468.9, + "Centroid Y µm": 21188.8, + "Num Detections": 17769, + "Num Negative": 17668, + "Num Positive": 101, + "Positive %": 0.5684, + "Num Positive per mm^2": 50.44 + } +} \ No newline at end of file diff --git a/434/TumorCenter_CD8_block3_x4_y8_patient434_1.json b/434/TumorCenter_CD8_block3_x4_y8_patient434_1.json new file mode 100644 index 0000000000000000000000000000000000000000..e6d3463e70f7aff2d7174db231d97308ce3458a8 --- /dev/null +++ b/434/TumorCenter_CD8_block3_x4_y8_patient434_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14092.5, + "Centroid Y µm": 21263.7, + "Num Detections": 23894, + "Num Negative": 20634, + "Num Positive": 3260, + "Positive %": 13.64, + "Num Positive per mm^2": 1352.9 + } +} \ No newline at end of file diff --git a/434/history_text.txt b/434/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/434/icd_codes.txt b/434/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5905a5914c5468c761c0538a36dfa9af5f7bf4ec --- /dev/null +++ b/434/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung, primäre Lokalisation unbekannt, so bezeichnet[C80.0 ] Carcinoma in situ des Hypopharynx[D00.0 ] \ No newline at end of file diff --git a/434/ops_codes.txt b/434/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..04fac699c38af2991b271cfab039307a03c206b3 --- /dev/null +++ b/434/ops_codes.txt @@ -0,0 +1 @@ +Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Mikrolaryngoskopie[1-610.2 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion][5-295.xx ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 L] \ No newline at end of file diff --git a/434/patient_clinical_data.json b/434/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..98a8cdf024c64fabfaee63f836029ca642b78532 --- /dev/null +++ b/434/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2016, + "age_at_initial_diagnosis": 63, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 64, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/434/patient_pathological_data.json b/434/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..5c1de27a454617b71a38d25ebe4575e2f70e14bf --- /dev/null +++ b/434/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "434", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT1", + "pN_stage": "pN2", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 16.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/434/surgery_description.txt b/434/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6c7bab243408b3ddea435e7db84512840a8bdf78 --- /dev/null +++ b/434/surgery_description.txt @@ -0,0 +1 @@ +CUP Panendoscopy, Laser resection of hypopharynx, Neck dissection diff --git a/434/surgery_report.txt b/434/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..40a6393680143e8322c68457e7f92e761d7d40ee --- /dev/null +++ b/434/surgery_report.txt @@ -0,0 +1 @@ +Initially induction of anesthesia, tracheoscopy performed. Unremarkable conditions in the trachea to carina area. Followed by transoral, endotracheal intubation. Positioning of the patient by the surgeon. A flexible esophagoscopy is performed using an endoscope, which is carefully advanced to the stomach under visualization. Inconspicuous conditions in the area of the entire oesophagus and stomach. Endoscopic inversion and inspection of the oesophago-gastric junction, with unremarkable findings. Retraction of the endoscope and performance of a rigid laryngo- and pharyngoscopy using a Kleinsasser C-tube. The endolarynx was completely unremarkable, the right piriform sinus, posterior wall of the hypopharynx and the postcricoidal region were unremarkable. In the area of the left piriform sinus and on its lateral wall, a tiny, spherical, exophytic mass covered by smooth mucosa was found, which was sent for an excisional biopsy for intraoperative frozen section examination. Subsequent inspection of the rest of the pharynx. The oropharyngeal region is completely normal. Samples are then taken from the right and left middle of the base of the tongue and hemostasis is performed using monopolar coagulation. Placement of the oral retractors and subsequent tonsillectomy, initially on the right side. Parauvular incision. Exposure of the upper pole. Hemostasis using bipolar coagulation. Exposure of the correct layer, capsular approach from cranial to caudal while sparing the anterior and posterior palatal arch. Deposition of the tonsil preparation in its lower pole, hemostasis there using bipolar coagulation. Subsequently, identical procedure on the left side. Parauvular incision, exposure of the upper pole, hemostasis there using bipolar coagulation. Exposure of the right capsular layer, dissection along the tonsil capsule from cranial to caudal. Hemostasis in the caudal pole using bipolar coagulation and placement of the tonsil preparation in the lower pole. Dry conditions. The right tonsil and the sample from the left hypopharynx are sent for intraoperative frozen section. The remaining samples were sent for final histology. The intraoperative frozen section examination resulted in a positive finding (G3 squamous cell carcinoma) in the area of the left hypopharynx. The findings were adjusted using a Kleinsasser C-tube and the laser beam was set to a power of 4 watts in continuous mode. Moving around the findings using the CO2 laser. Removal of the sampling region in toto. Subsequently, 3 marginal samples (anterior wall of the piriform sinus, median wall of the piriform sinus, lateral wall of the piriform sinus) which are sent for final examination. Hemostasis there using monopolar coagulation. Removal of the Kleinsasser tube and subsequent repositioning of the patient for the planned neck dissection on the left side. Application of local anesthesia there after skin spray disinfection. Ablate the skin, sterile draping. Make an incision along the anterior edge of the sternocleidomastoid muscle. Cut through the subcutaneous tissue and the platysma. Exposure of the anterior border of the sternocleidomastoid muscle, exposure of the accessorius nerve, exposure of the omohyoid muscle, exposure cranial to the posterior venter of the digastric muscle. A large metastasis is already visible in this area. Dissection of the metastasis from the accessorius nerve, the internal jugular vein and the facial vein as well as from the posterior venter of the digaster muscle. Removal of the same in toto. Subsequent dissection along the cervical vascular sheath from caudal to cranial. Protection of the cervical vascular sheath structures. Successive removal of the posterior neck specimen while sparing the plexus branches. This revealed several metastases. Removal of the anterior neck specimen, where further metastases were found. Dry conditions. Treatment of region V with multiple ligatures to avoid a chyle fistula. Dry conditions. Wound irrigation with hydrogen peroxide and Ringer's solution. Repeated inspection. Placement of a 10-gauge Redon drain. Two-layer wound closure. Completion of the procedure without complications. Conclusion: CUP panendoscopy, laser resection of a cT1 G3 hypopharyngeal carcinoma on the left side confirmed by intraoperative frozen section, modified radical neck resection while sparing the internal jugular vein and the accessory nerve and sternocleidomastoid muscle. Please plan PEG placement and prompt presentation of the patient to our interdisciplinary tumor conference for further planning (cave: M1 situation pulmonary left). \ No newline at end of file diff --git a/435/InvasionFront_CD3_block14_x5_y11_patient435_0.json b/435/InvasionFront_CD3_block14_x5_y11_patient435_0.json new file mode 100644 index 0000000000000000000000000000000000000000..8749272d16ad1af313d596ee9c7934437a6eccdc --- /dev/null +++ b/435/InvasionFront_CD3_block14_x5_y11_patient435_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16391.3, + "Centroid Y µm": 31608.3, + "Num Detections": 22036, + "Num Negative": 20399, + "Num Positive": 1637, + "Positive %": 7.429, + "Num Positive per mm^2": 644.12 + } +} \ No newline at end of file diff --git a/435/InvasionFront_CD3_block14_x6_y11_patient435_1.json b/435/InvasionFront_CD3_block14_x6_y11_patient435_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ff47105278c7c9eda9e3796845b87a12b21fa4e2 --- /dev/null +++ b/435/InvasionFront_CD3_block14_x6_y11_patient435_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19014.9, + "Centroid Y µm": 31783.2, + "Num Detections": 19516, + "Num Negative": 18732, + "Num Positive": 784, + "Positive %": 4.017, + "Num Positive per mm^2": 323.43 + } +} \ No newline at end of file diff --git a/435/InvasionFront_CD8_block14_x5_y11_patient435_0.json b/435/InvasionFront_CD8_block14_x5_y11_patient435_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ddb1a22c7fcf2be14af958187242e0ba89db3540 --- /dev/null +++ b/435/InvasionFront_CD8_block14_x5_y11_patient435_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 16541.2, + "Centroid Y µm": 27010.7, + "Num Detections": 22597, + "Num Negative": 21039, + "Num Positive": 1558, + "Positive %": 6.895, + "Num Positive per mm^2": 625.63 + } +} \ No newline at end of file diff --git a/435/InvasionFront_CD8_block14_x6_y11_patient435_1.json b/435/InvasionFront_CD8_block14_x6_y11_patient435_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b7777a40d2f452b01d741dfa059733268014f2f --- /dev/null +++ b/435/InvasionFront_CD8_block14_x6_y11_patient435_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 19089.9, + "Centroid Y µm": 27135.6, + "Num Detections": 20639, + "Num Negative": 20087, + "Num Positive": 552, + "Positive %": 2.675, + "Num Positive per mm^2": 230.27 + } +} \ No newline at end of file diff --git a/435/TumorCenter_CD3_block14_x5_y11_patient435_0.json b/435/TumorCenter_CD3_block14_x5_y11_patient435_0.json new file mode 100644 index 0000000000000000000000000000000000000000..3ccb2acc7229eda04fc6dcee29c5f5d584a2bf12 --- /dev/null +++ b/435/TumorCenter_CD3_block14_x5_y11_patient435_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15891.6, + "Centroid Y µm": 28060.1, + "Num Detections": 20130, + "Num Negative": 16309, + "Num Positive": 3821, + "Positive %": 18.98, + "Num Positive per mm^2": 1537.9 + } +} \ No newline at end of file diff --git a/435/TumorCenter_CD3_block14_x6_y11_patient435_1.json b/435/TumorCenter_CD3_block14_x6_y11_patient435_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9790a33f0c9ab1bce39b4f3442b11792db62d51d --- /dev/null +++ b/435/TumorCenter_CD3_block14_x6_y11_patient435_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18465.2, + "Centroid Y µm": 28160.1, + "Num Detections": 22405, + "Num Negative": 20833, + "Num Positive": 1572, + "Positive %": 7.016, + "Num Positive per mm^2": 627.27 + } +} \ No newline at end of file diff --git a/435/TumorCenter_CD8_block14_x5_y11_patient435_0.json b/435/TumorCenter_CD8_block14_x5_y11_patient435_0.json new file mode 100644 index 0000000000000000000000000000000000000000..327fe6e5b81b6fbcba425635913ef1deb389ea27 --- /dev/null +++ b/435/TumorCenter_CD8_block14_x5_y11_patient435_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15491.8, + "Centroid Y µm": 28010.2, + "Num Detections": 19761, + "Num Negative": 16674, + "Num Positive": 3087, + "Positive %": 15.62, + "Num Positive per mm^2": 1241.8 + } +} \ No newline at end of file diff --git a/435/TumorCenter_CD8_block14_x6_y11_patient435_1.json b/435/TumorCenter_CD8_block14_x6_y11_patient435_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ac466d5ff5d90e78ed5d5d829becf78ad30f747e --- /dev/null +++ b/435/TumorCenter_CD8_block14_x6_y11_patient435_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18040.4, + "Centroid Y µm": 28035.2, + "Num Detections": 21373, + "Num Negative": 20191, + "Num Positive": 1182, + "Positive %": 5.53, + "Num Positive per mm^2": 479.45 + } +} \ No newline at end of file diff --git a/435/history_text.txt b/435/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..81ec4081d3d0d0855273ffa5ecf1d801d9c2b31f --- /dev/null +++ b/435/history_text.txt @@ -0,0 +1 @@ +The patient has an externally histologically confirmed squamous cell carcinoma of the tongue. In the panendoscopy performed <2015>, a tongue margin to tongue body carcinoma on the left was also confirmed clinically. Therefore indication for the above-mentioned procedure. \ No newline at end of file diff --git a/435/icd_codes.txt b/435/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..b8bb53ea6db4bcb7c44e7b39b161463a30e7bf60 --- /dev/null +++ b/435/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Zunge mehrere Teilbereiche überlappend[C02.8 ] \ No newline at end of file diff --git a/435/ops_codes.txt b/435/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..03edb029baf58b191acff4f054b002c5168ec820 --- /dev/null +++ b/435/ops_codes.txt @@ -0,0 +1 @@ +Sonstige partielle Glossektomie Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-251.x2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Spalthaut Entnahmestelle Fuß[5-901.0g R] Spalthaut großflächig Empfängerstelle Unterarm[5-902.48 L] Permanente Tracheotomie[5-312.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Entnahme freier Radialis-Lappen[5-858.23 L] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 B] Lokale Exzision Mundboden[5-273.3 ] \ No newline at end of file diff --git a/435/patient_clinical_data.json b/435/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..4ca59668cfcdeb494ca1df47e35fc2de11aeead9 --- /dev/null +++ b/435/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2015, + "age_at_initial_diagnosis": 75, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/435/patient_pathological_data.json b/435/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..183b1ceb6f9b884de845da57a96e40121f7e1a79 --- /dev/null +++ b/435/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "435", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT2", + "pN_stage": "pN0", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 16, + "perinodal_invasion": null, + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": null, + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/435/surgery_description.txt b/435/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..4436658106e19271315cc0ebdd08b680b93ce267 --- /dev/null +++ b/435/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Modified radical neck dissection, and Tracheotomy diff --git a/435/surgery_report.txt b/435/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..01e6b63111482ba153fa60ce8aec971f33b68a31 --- /dev/null +++ b/435/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation by the anesthesia colleagues. Then determination of the external tumor morphology using narrow-band imaging and contact endoscope. Targeted biopsies are taken to verify the narrow-band imaging images and the biopsies are sent for final histology. Then start with tumor resection with a safety margin of at least 1-1.5 cm in the area of the tongue. The carcinoma has extensions within the tongue that go beyond the midline in the area of the tip of the tongue and also extend to the underside of the tongue. The tumor is removed en bloc. Then take marginal samples directly from the specimen. The marginal samples are all tumor-free. Then perform the neck dissection on the left side. To do this, make a skin incision in a transverse skin fold. Separation of the platysma. Dissection of the platysma cranially. Exposure of the sternocleidomatoid muscle. Exposure of the omohyoid muscle and the submandibular gland, the digastric muscle, the internal jugular vein and the facial vein as well as the external carotid artery, the facial artery and the superior thyroid artery. Clearing of neck levels IIa to Va while sparing the hypoglossal nerve, accessory nerve and plexus branches. The superior thyroid artery has an extremely small lumen. This is not suitable for a later graft connection. The facial artery and the facial vein are more suitable for this. Then work in parallel and perform the neck dissection on the right side through and . Dictation: . Skin incision and dissection through the subcutaneous fatty tissue. Locate the external jugular vein. This is ligated. Further dissection through the platysma and subplatysmal. Bluntly spread subplatysmal with the pedicle. Now locate the anterior border of the sternocleidomastoid muscle and dissect the anterior border caudally. Anterior transection of the dermal fibers via region II b. Locate the accessorius nerve. Now expose the omohyoid muscle up to the hyoid. Locate the submandibular gland and approach the capsule sharply. Pull up the gland with the Langenbeck and locate the digaster muscle. Blunt dissection with the clamp anteriorly and posteriorly on the digaster. Clear the triangle between the omohyoid and digaster anteriorly and the sternocleidomastoid and digaster posteriorly. The accessorius nerve can be spared at any time without any problems. Now dissect the medial neck triangle along the cervical nerve. Release the medial neck preparation. Dissection of the internal jugular vein in its entirety. Locate the common carotid artery and the vagus nerve. When preparing the medial neck preparation, the superior thyroid vein is ligated. Now dissect the lateral neck preparation from cranial to caudal. The accessor nerve can also be spared here. The hypoglossal nerve is exposed and is also spared. Dissection in depth down to the cervical plexus. Levels II to IV are carefully dissected out. Hilus is not visible. The cervical sinus can be preserved. If there is no increased bleeding and the wound is free of irritation, hydrogen and ring irrigation, two-layer wound closure. Lifting of the radialis graft by and PJ. Marking of the graft on the forearm, then unwrapping of the graft and setting of the tourniquet. The graft is 9 x 6 mm in size and is incised. Exposure of the brachioradialis muscle, exposure of the radial ramus superficialis nerve, which is divided into 2 branches. Exposure of the radial artery. Ligation and transection of the radial artery, then lifting of the graft from the tendons and dissection of the pedicle up to the antecubital fossa. There is good confluence between the superficial and deep venous system in the antecubital fossa. However, the cephalic vein could not be integrated into the graft as it is located too far laterally. Nevertheless, the part of the cephalic vein that lies proximal to the venous confluence is prepared for a connection and a further venous connection from the deep system. Deposition of the graft, then suturing of the graft in the tongue area. Reconstruction of the tip of the tongue by incising and suturing the graft to form a rounded tongue tip, which is adapted to the remaining tongue tip defect. During neck dissection, a tunnel was created to the tongue in the mouth area. The submandibular gland was removed and the digastric muscle was severed to create a passage 3 fingers wide. The stalk was guided outwards here. The radial artery was anastomosed to the facial artery and the veins to the facial vein and the second vein to a direct outlet from the internal jugular vein. A size 2.5 coupler was used for this. Finally, the tracheotomy was performed. For this, a skin incision was made below the cricoid cartilage. Dissection down to the musculature. Push the muscles aside. Enter the trachea between the 1st and 2nd tracheal cartilage and create a muco-cutaneous anastomosis. Re-intubation to an 8 mm tracheal cannula. If the flap is well perforated, the patient is ventilated and admitted to the intensive care unit. Please continue antibiotics for 24 hours. Nutrition for 10 days via the PEG tube, then if necessary, X-ray pre-swallow and cautious diet build-up. \ No newline at end of file diff --git a/436/InvasionFront_CD3_block11_x1_y11_patient436_0.json b/436/InvasionFront_CD3_block11_x1_y11_patient436_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4dad528b374e63f4cfaa4f5551e1ab13d38928d5 --- /dev/null +++ b/436/InvasionFront_CD3_block11_x1_y11_patient436_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3972.9, + "Centroid Y µm": 26960.7, + "Num Detections": 17859, + "Num Negative": 16146, + "Num Positive": 1713, + "Positive %": 9.592, + "Num Positive per mm^2": 784.45 + } +} \ No newline at end of file diff --git a/436/InvasionFront_CD3_block11_x2_y11_patient436_1.json b/436/InvasionFront_CD3_block11_x2_y11_patient436_1.json new file mode 100644 index 0000000000000000000000000000000000000000..1877f7634396e42b6387cb475c98e3ff77cd16bb --- /dev/null +++ b/436/InvasionFront_CD3_block11_x2_y11_patient436_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 26785.8, + "Num Detections": 19101, + "Num Negative": 12858, + "Num Positive": 6243, + "Positive %": 32.68, + "Num Positive per mm^2": 3005.4 + } +} \ No newline at end of file diff --git a/436/InvasionFront_CD8_block11_x1_y11_patient436_0.json b/436/InvasionFront_CD8_block11_x1_y11_patient436_0.json new file mode 100644 index 0000000000000000000000000000000000000000..feedd877bb8bca670a98de718285977c0a16cab2 --- /dev/null +++ b/436/InvasionFront_CD8_block11_x1_y11_patient436_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6582.7, + "Centroid Y µm": 38003.4, + "Num Detections": 17673, + "Num Negative": 16894, + "Num Positive": 779, + "Positive %": 4.408, + "Num Positive per mm^2": 358.49 + } +} \ No newline at end of file diff --git a/436/InvasionFront_CD8_block11_x2_y11_patient436_1.json b/436/InvasionFront_CD8_block11_x2_y11_patient436_1.json new file mode 100644 index 0000000000000000000000000000000000000000..64507676c3e958ef3f253d322a4563db4933a703 --- /dev/null +++ b/436/InvasionFront_CD8_block11_x2_y11_patient436_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8988.9, + "Centroid Y µm": 37999.0, + "Num Detections": 18746, + "Num Negative": 17488, + "Num Positive": 1258, + "Positive %": 6.711, + "Num Positive per mm^2": 732.26 + } +} \ No newline at end of file diff --git a/436/TumorCenter_CD3_block11_x1_y11_patient436_0.json b/436/TumorCenter_CD3_block11_x1_y11_patient436_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c54a542ffb8a5371a5caf0c13318211151b6dd50 --- /dev/null +++ b/436/TumorCenter_CD3_block11_x1_y11_patient436_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6396.6, + "Centroid Y µm": 26710.9, + "Num Detections": 17902, + "Num Negative": 16199, + "Num Positive": 1703, + "Positive %": 9.513, + "Num Positive per mm^2": 803.15 + } +} \ No newline at end of file diff --git a/436/TumorCenter_CD3_block11_x2_y11_patient436_1.json b/436/TumorCenter_CD3_block11_x2_y11_patient436_1.json new file mode 100644 index 0000000000000000000000000000000000000000..c2289aceecc0ae6397d6aad7134a5c5a53d061a4 --- /dev/null +++ b/436/TumorCenter_CD3_block11_x2_y11_patient436_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 8695.4, + "Centroid Y µm": 26935.7, + "Num Detections": 18308, + "Num Negative": 16308, + "Num Positive": 2000, + "Positive %": 10.92, + "Num Positive per mm^2": 926.53 + } +} \ No newline at end of file diff --git a/436/TumorCenter_CD8_block11_x1_y11_patient436_0.json b/436/TumorCenter_CD8_block11_x1_y11_patient436_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ae7b7a71b6070546fe950ac373c079e3ec11ec2f --- /dev/null +++ b/436/TumorCenter_CD8_block11_x1_y11_patient436_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3897.9, + "Centroid Y µm": 26910.8, + "Num Detections": 17211, + "Num Negative": 15868, + "Num Positive": 1343, + "Positive %": 7.803, + "Num Positive per mm^2": 605.74 + } +} \ No newline at end of file diff --git a/436/TumorCenter_CD8_block11_x2_y11_patient436_1.json b/436/TumorCenter_CD8_block11_x2_y11_patient436_1.json new file mode 100644 index 0000000000000000000000000000000000000000..467e3a871c919ad2b45b7dabac993f7b55729ac5 --- /dev/null +++ b/436/TumorCenter_CD8_block11_x2_y11_patient436_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6271.7, + "Centroid Y µm": 26935.7, + "Num Detections": 17062, + "Num Negative": 14697, + "Num Positive": 2365, + "Positive %": 13.86, + "Num Positive per mm^2": 1049.2 + } +} \ No newline at end of file diff --git a/436/history_text.txt b/436/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..3368c3eab66fb2450bc11398d252f80cdc421b16 --- /dev/null +++ b/436/history_text.txt @@ -0,0 +1 @@ +In the patient, a cT2 oropharyngeal carcinoma on the right was histologically confirmed during a panendoscopy <2012>. Sonography showed a cN 2c neck status directly preoperatively, the CT scan performed showed no evidence of distant metastasis. \ No newline at end of file diff --git a/436/icd_codes.txt b/436/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..ed99acc248a2592d3b52f719c58ff954937c790a --- /dev/null +++ b/436/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, nicht näher bezeichnet[C10.9 ] \ No newline at end of file diff --git a/436/ops_codes.txt b/436/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..19395938cbc7eedcba43b78f64921b7dd44975fe --- /dev/null +++ b/436/ops_codes.txt @@ -0,0 +1 @@ +Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Entnahme sonstiges Transplantat mit mikrovaskulärer Anastomosierung Unterarm[5-858.43 L] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 L] Perkutane [endoskopische] Gastrostomie [PEG][5-431.2 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] \ No newline at end of file diff --git a/436/patient_clinical_data.json b/436/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3f15363f9d0ff457f8ffa64849a85bb990bc94e4 --- /dev/null +++ b/436/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2012, + "age_at_initial_diagnosis": 51, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 38, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/436/patient_pathological_data.json b/436/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3bbe164f9840def28e653ba01a7c2231aa421a53 --- /dev/null +++ b/436/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "436", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN0", + "grading": "G2", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 0.0, + "number_of_resected_lymph_nodes": 55, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 10.0 +} \ No newline at end of file diff --git a/436/surgery_description.txt b/436/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..14c95ecef527810d44658de42042415919483fdf --- /dev/null +++ b/436/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect coverage, Free flap (Radial), PEG placement diff --git a/436/surgery_report.txt b/436/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..96812f57ad77cfa7f5706dd505c9e4025c689f5c --- /dev/null +++ b/436/surgery_report.txt @@ -0,0 +1 @@ +First start with the PEG insertion. Entering with the gastroscope under laryngoscopic control. Easy pre-scanning into the stomach. If diaphanoscopy is good and the stomach has been punctured without any problems, the PEG tube is inserted using the usual thread pull-through method. After repositioning the patient, turn to pharyngoscopy and inspect the primary tumor. There is an exophytic process in the area of the right tonsil, which partially reaches the soft palate via the anterior palatal arch and the posterior palatal arch. Right-sided subtotal infiltration and consumption of the uvula. Infiltration of the base of the uvula on the left side, macroscopically on the right side, right caudally, not exceeding the tonsil lobe, also palpatorily no indication of deep infiltration in the cervical direction. The tumor is now resected with partial soft palate resection with a safety margin of approx. 1.5 cm. Release of the tumorously altered tonsil with lateral preservation of a soft tissue mantle. Complete removal of the posterior palatal arch, also here removal of muscles on all sides. Deposition at the lower tonsil pole. Inspection reveals a macroscopically and palpatorily clearly resected tumor in sano. The specimen is thread-marked on all sides for frozen section diagnostics and is diagnosed here as a squamous cell carcinoma resected in sano. Inspection of the defect. There is a clear soft palate in the defect. Approximately 2 cm of the soft palate have been subtotally resected. Subtotal resection of the posterior palatal arch so that the defect in the area of the tonsillar lobe is resected. Measurement of a 0.5 x 4.5 cm graft with separate logging for the soft palate. The neck is first dissected on the left side. To do this, cut through the skin and subcutaneous tissue along the sternocleidomastoid muscle. Exposure and dissection of the platysma. Creation of a platysma flap. Exposure and preservation of the external jugular vein, which is very slender here. Exposure of the sternocleidomastoid muscle. Exposure of a strong transcervical vein. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery as well as the cervical artery and the hypoglossal nerve. A very strong anterior jugular vein can be seen here. A true facial vein is not present here. Some of the sides of the anterior jugular vein are ligated, but overall it is preserved as a vessel. The vein takes up the submandibular region via the lateral branches. The branches are also preserved here. Complete exposure of the digastric muscle. Exposure and free preparation of the internal jugular vein while carefully preserving the vessel. Exposure of the accessory nerve. Level 2 shows a hardened palpable lymph node measuring approx. 2.5 x 1.5 cm on the internal jugular vein. Macroscopically quite suspicious, but without perinodal and nodal growth. Finally, evacuation of the accessorius triangle with careful protection and evacuation of level 5 with careful protection of the cervical plexus branches as well as caudal dry conditions without lymph vessel alteration. Final wound inspection with dry conditions on palpation. No further masses, no bleeding. Wound irrigation with Ringer's solution and after insertion of a 10-gauge Redon drainage, careful two-layer wound closure. The neck dissection of the right side is now carried out in parallel and the radialis graft is lifted for neck dissection. Basically the same procedure as on the opposite side. Cut through the skin and subcutaneous tissue along the anterior edge of the muscle. Expose and cut through the platysma. Exposure and preservation of the external jugular vein and auricular nerve. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Visualization of the submandibular gland. Exposure of the digastric muscle. Removal of the anterior neck preparation, carefully preserving the superior thyroid artery, the cervical artery and the hypoglossal nerve. Exposure of the accessorius nerve. Dissection of the internal jugular vein. The size and shape of the lymph nodes are conspicuous in level 2 and in the transition to level 3, so that the cN2c neck status can be confirmed intraoperatively. Clearing of the accessorius triangle with careful protection of the nerve. Evacuation of level 5 with careful protection of the cervical plexus branches. There is also no true facial vein on the right side. Strong upper thyroid branch. This is prepared for later anastomization, and the superior thyroid artery is also dissected, although it is relatively slender, so the faciliac artery is also prepared. The carotid artery is now dissected cranially after removal of the digastric muscle. Dissection up to the styloid, then the pharyngotomy can be performed in the area of the tonsillar lobe by transoral control. Widen the pharyngotomy, taking the surrounding muscles with it. This results in a tunnel a good two transverse fingers wide. Now to lift the radialis graft. After marking the graft, identify the radial artery by palpation and the cephalic vein. Perform the tourniquet. Cut around the graft. Radial start. Exposure of the cephalic vein. Exposure of the brachialis muscle. Exposure of the Haydn maneuver. Exposure and securing of the superficial ramus, radial nerve. Exposure of the distal vascular pedicle. Blunt cutting of the vascular pedicle distally after ligation, strictly subfascial release. After complete exposure of the brachioradialis muscle with isolation and removal of the cephalic vein. Inappropriate dissection, exposure and dissection of the flexor carpi ulnaris muscle. Exclusion of a superficial ulnar artery. Complete release of the graft with careful clipping of outgoing vessels. Isolation on the vascular pedicle with the radial artery and accompanying veins as well as additional elevation of the strong cephalic vein. Expose a strong bridge of the accompanying veins to the cephalic vein and, if the accompanying vein is relatively confluent, take the bridge branch and isolate it on the cephalic vein after clipping the remaining branches of the outgoing veins. Exposure of the branch of the radial artery. Exposure of the outlet of the anterior interosseous artery and the powerful ulnar artery. Both vessels are left intact and spared. Re-opening of the tourniquet with uterine hemostasis with a vital, regular graft and regular blood supply to the hand. Finally, after careful hemostasis in the case of a vital graft, the graft is removed. Subsequent careful two-layer wound closure. Removal of the full-thickness skin graft from the groin and final application of a vacuum sealing bandage and the cramp splint in the functional position and repositioning of the arm. For full-thickness skin harvesting from the groin on the right, mark a full-thickness skin graft measuring a good 10 x 5 cm. Cut around the skin with strict cutaneous elevation. Careful subcutaneous mobilization. Meticulous hemostasis and careful multi-layer wound closure under moderate tension after insertion of a 10-gauge Redon drain. The radialis graft is now inserted transcervically. Gradual insertion of the graft under soft palate reconstruction and doubling of the graft. Careful insertion of the tonsil lobe. Finally, dense conditions and good adaptation conditions. Microscopic conditioning of the pedicle vessels, very strong radial artery and strong cespal vein. First conditioning of the superior thyroid artery. A very slender vessel can now be seen here, even after removal, so that the superior thyroid artery is clipped. Dissection of the facial artery. ......... of the vessel. Moderate difference in caliber with further caliber advantage of the radial artery. Conditioning of the vessels and successive caliber-adapted anastomization with 8.0 Ethilon, this is laborious, but finally succeeds well and adequately with immediate regular venous return and regular flap perfusion. Now conditioning of the superior thyroid vein in order to achieve some degree of caliber equivalence, this must be placed relatively close to the internal jugular vein. Measure a coupler of size 3.0 and perform the venous anastomosis with the coupler. Immediate regular venous return after reopening of the artery, regular perfusion with regular pedicle pulsation and good graft perfusion. Multiple inspections. Enoral conditions remain lean, therefore a defect limited to the tonsillar lobe and the soft palate is avoided, a tracheostomy is not performed and the procedure is terminated after the patient has been repositioned. The patient received intraoperative i.V. antibiotic treatment with Unacid 3 g. This should be continued for 24 hours and a single-shot administration of 250 mg SDH to prevent swelling. Conclusion: Intraoperative R0 resected cT2 cN2c oropharyngeal carcinoma on the right. From the 8th postoperative day onwards, with a properly healing graft and dense conditions, a gradual increase in diet is possible. Postoperatively, please monitor the flap meticulously by enoral inspection. Note: On the right cervical side, the course of the pedicle is relatively close to the subcutaneous level of the carotid bulb. Please strictly avoid pressure bandages here and exercise caution when opening if necessary. \ No newline at end of file diff --git a/437/InvasionFront_CD8_block20_x3_y12_patient437_0.json b/437/InvasionFront_CD8_block20_x3_y12_patient437_0.json new file mode 100644 index 0000000000000000000000000000000000000000..78b7156dc64da2daa58df87cfc549661e675ec9e --- /dev/null +++ b/437/InvasionFront_CD8_block20_x3_y12_patient437_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12418.4, + "Centroid Y µm": 29884.2, + "Num Detections": 18722, + "Num Negative": 18109, + "Num Positive": 613, + "Positive %": 3.274, + "Num Positive per mm^2": 280.31 + } +} \ No newline at end of file diff --git a/437/InvasionFront_CD8_block20_x4_y12_patient437_1.json b/437/InvasionFront_CD8_block20_x4_y12_patient437_1.json new file mode 100644 index 0000000000000000000000000000000000000000..9171e57f74a821e7cd834d224c00c372154bbc04 --- /dev/null +++ b/437/InvasionFront_CD8_block20_x4_y12_patient437_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14992.1, + "Centroid Y µm": 29809.2, + "Num Detections": 19666, + "Num Negative": 18392, + "Num Positive": 1274, + "Positive %": 6.478, + "Num Positive per mm^2": 561.63 + } +} \ No newline at end of file diff --git a/437/TumorCenter_CD3_block20_x3_y12_patient437_0.json b/437/TumorCenter_CD3_block20_x3_y12_patient437_0.json new file mode 100644 index 0000000000000000000000000000000000000000..c0b48470d6ea13c71a4e23292333811891520308 --- /dev/null +++ b/437/TumorCenter_CD3_block20_x3_y12_patient437_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11047.3, + "Centroid Y µm": 28888.0, + "Num Detections": 6997, + "Num Negative": 5448, + "Num Positive": 1549, + "Positive %": 22.14, + "Num Positive per mm^2": 853.59 + } +} \ No newline at end of file diff --git a/437/TumorCenter_CD3_block20_x4_y12_patient437_1.json b/437/TumorCenter_CD3_block20_x4_y12_patient437_1.json new file mode 100644 index 0000000000000000000000000000000000000000..65e6e602df7500c1bca573c418090158a598cf8f --- /dev/null +++ b/437/TumorCenter_CD3_block20_x4_y12_patient437_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13599.2, + "Centroid Y µm": 28899.8, + "Num Detections": 13424, + "Num Negative": 12644, + "Num Positive": 780, + "Positive %": 5.81, + "Num Positive per mm^2": 384.73 + } +} \ No newline at end of file diff --git a/437/TumorCenter_CD8_block20_x3_y12_patient437_0.json b/437/TumorCenter_CD8_block20_x3_y12_patient437_0.json new file mode 100644 index 0000000000000000000000000000000000000000..08e9f1a5b81adcfb5cb4533be9ccf27fbd79549b --- /dev/null +++ b/437/TumorCenter_CD8_block20_x3_y12_patient437_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11468.9, + "Centroid Y µm": 29909.2, + "Num Detections": 19757, + "Num Negative": 18790, + "Num Positive": 967, + "Positive %": 4.894, + "Num Positive per mm^2": 422.19 + } +} \ No newline at end of file diff --git a/437/TumorCenter_CD8_block20_x4_y12_patient437_1.json b/437/TumorCenter_CD8_block20_x4_y12_patient437_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0dcbc8bfb2c6f172cf4937af571aba02d3dc316c --- /dev/null +++ b/437/TumorCenter_CD8_block20_x4_y12_patient437_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 29859.2, + "Num Detections": 18580, + "Num Negative": 18080, + "Num Positive": 500, + "Positive %": 2.691, + "Num Positive per mm^2": 221.97 + } +} \ No newline at end of file diff --git a/437/history_text.txt b/437/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/437/icd_codes.txt b/437/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..3a61f02515b385e6620a885bed3fcb16c44d4f69 --- /dev/null +++ b/437/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Glottis[C32.0 ] Glottiskarzinom[C32.0 ] \ No newline at end of file diff --git a/437/ops_codes.txt b/437/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..34279b88d4948398ef6794dbfb43846bc4b2e1c6 --- /dev/null +++ b/437/ops_codes.txt @@ -0,0 +1 @@ +Sonstige einfache Laryngektomie[5-303.0x ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 B] PEG-Sonde Anlage[5-431.2 ] Diagnostische Ösophagogastroskopie[1-631 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Offene pharyngozervikale Ösophagomyotomie[5-420.11 ] \ No newline at end of file diff --git a/437/patient_clinical_data.json b/437/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ecb64f26dbef5a7f311c18b1158095f950bbd3e2 --- /dev/null +++ b/437/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 64, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "yes", + "survival_status": "deceased", + "survival_status_with_cause": "deceased tumor specific", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 30, + "adjuvant_treatment_intent": null, + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/437/patient_pathological_data.json b/437/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..ba6fe5d9399f68077af7c86193ae10d752e6f4dc --- /dev/null +++ b/437/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "437", + "primary_tumor_site": "Larynx", + "pT_stage": "pT4a", + "pN_stage": "pN1", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 24, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/437/surgery_description.txt b/437/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..fe46b8d204657f7ea44267a33a8c88406bc8eff3 --- /dev/null +++ b/437/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Neck dissection, and PEG placement diff --git a/437/surgery_report.txt b/437/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..05d0515438c198280c831e43ab8d18b296697b57 --- /dev/null +++ b/437/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and nasal intubation by the anesthetist. First, pharyngoscopy and inspection of the glottic plane. This reveals an exophytic mass in the right anterior commissure with transition to the left third of the vocal folds and extension to the pocket folds. Inspection of the piriform sinus on both sides. No tumorous mass on either side. Insertion of a nasogastric tube and insertion with the flexible endoscope and endoscopy up to the stomach. Inspection of the stomach. Inconspicuous conditions on all sides. Perform PEG insertion (, ) using the thread pull-through method. Repositioning for laryngectomy and neck dissection. Creation of an apron flap with subplatysmal dissection in the typical manner up to the level of the hyoid bone. The skin and platysma flap is then folded upwards and fixed with holding sutures. Start of neck dissection on the right side through . Exposure of the sternocleidomastoid muscle, the omohyoid muscle and the submandibular gland. Then visualization of the digastric muscle. Finding the accessorius nerve and the cervical vascular sheath. Then free preparation of the internal jugular vein. Visualization of the vagus nerve, the internal and external carotid artery, the accessorius nerve and the hypoglossal nerve. Then release of the neck preparation in levels II to V while sparing the cervical plexus branches. Free preparation of the facial vein and release of the medial part of the neck. Transition to the opposite side and neck dissection on the left side. In principle the same procedure as on the right. Exposure of the sternocleidomastoid and omohyoid muscles. Exposure of the submandibular gland and also exposure of the digastric muscle. Exposure of the accessor nerve and exposure of the cervical vascular sheath. Visualization of the internal jugular vein, internal and external carotid artery, vagus nerve and hypoglossal nerve. Then release of neck levels II to V while sparing the branches of the cervical plexus and the accessorius nerve. Exposure of the facial vein and release of the medial part of the neck. Transition to laryngectomy. First dissection of the infrahyoid muscles on the hyoid bone. Exposure of the upper horn of the thyroid cartilage and dissection of the prelaryngeal musculature. Exposure of the thyroid gland. Dissection and ligation of the thyroid isthmus. Exposure of the anterior wall of the trachea. This is very difficult because the patient has already undergone a biopsy in this area. Some lymph nodes are still visible here, which are sent in for histology. Entering the trachea between the 1st and 2nd tracheal cartilage. Creation of a mucocutaneous anastomosis and reintubation onto a laryngectomy tube. Further skeletonization of the larynx and detachment of the piriform sinus and the pharyngeal tube from the larynx. Creation of a pharyngotomy at the upper edge of the larynx. Extraction of the epiglottis and removal of the larynx with further opening of the pharyngeal tube. The larynx is removed from the trachea below the cricoid cartilage. Inspection of the pharyngeal tube and the esophagus. Now performs the myotomy on the esophagus. Here in the anterior position. Then call and intraoperative demonstration of the placement of a Provox 80 prosthesis in a typical manner. Then transition to pharyngeal suture. This is performed in a typical multi-layered manner. First, single button sutures on the mucosa so that the mucosa can be adapted inverted. Then a second inverting suture over the pharyngeal tube using single button sutures. Suture the pharyngeal constrictor muscle so that the pharyngeal tube is well sealed from cranial to caudal. Once again careful hemostasis using bipolar coagulation. Insertion of two Redon drains. Completion of the mucocutaneous anastomosis to create a tracheostoma. Two-layer wound closure. Insertion of a 10 mm tracheostomy tube. Sterile wound dressing and completion of the operation without complications. \ No newline at end of file diff --git a/438/InvasionFront_CD3_block14_x3_y5_patient438_0.json b/438/InvasionFront_CD3_block14_x3_y5_patient438_0.json new file mode 100644 index 0000000000000000000000000000000000000000..56b2dd350391eb34cbbca881a237d285d4a369d3 --- /dev/null +++ b/438/InvasionFront_CD3_block14_x3_y5_patient438_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11993.6, + "Centroid Y µm": 16191.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/InvasionFront_CD3_block14_x4_y5_patient438_1.json b/438/InvasionFront_CD3_block14_x4_y5_patient438_1.json new file mode 100644 index 0000000000000000000000000000000000000000..5e34e5b5c2c7c8cf18f0febdd83451568bd0d229 --- /dev/null +++ b/438/InvasionFront_CD3_block14_x4_y5_patient438_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14492.3, + "Centroid Y µm": 16291.4, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/InvasionFront_CD8_block14_x3_y5_patient438_0.json b/438/InvasionFront_CD8_block14_x3_y5_patient438_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4683b30fcb867cdeb0a69e57337e8a5c818a5f2a --- /dev/null +++ b/438/InvasionFront_CD8_block14_x3_y5_patient438_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11956.2, + "Centroid Y µm": 12281.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/InvasionFront_CD8_block14_x4_y5_patient438_1.json b/438/InvasionFront_CD8_block14_x4_y5_patient438_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f638d633b29f9c299da20c81b5c17aac5d5a7099 --- /dev/null +++ b/438/InvasionFront_CD8_block14_x4_y5_patient438_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14554.8, + "Centroid Y µm": 12243.5, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/TumorCenter_CD3_block14_x3_y5_patient438_0.json b/438/TumorCenter_CD3_block14_x3_y5_patient438_0.json new file mode 100644 index 0000000000000000000000000000000000000000..ff5819dc17ee0bf4e99201d2a9f8054359d4df9b --- /dev/null +++ b/438/TumorCenter_CD3_block14_x3_y5_patient438_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11793.8, + "Centroid Y µm": 12843.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/TumorCenter_CD3_block14_x4_y5_patient438_1.json b/438/TumorCenter_CD3_block14_x4_y5_patient438_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d57fe9dbd45ad86b71f376b2b46700e3e5f651c6 --- /dev/null +++ b/438/TumorCenter_CD3_block14_x4_y5_patient438_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14367.4, + "Centroid Y µm": 13018.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/TumorCenter_CD8_block14_x3_y5_patient438_0.json b/438/TumorCenter_CD8_block14_x3_y5_patient438_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f51e4ac88cc2c3bb4c04cbfe01cd9d68db6a642f --- /dev/null +++ b/438/TumorCenter_CD8_block14_x3_y5_patient438_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10744.3, + "Centroid Y µm": 13068.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/TumorCenter_CD8_block14_x4_y5_patient438_1.json b/438/TumorCenter_CD8_block14_x4_y5_patient438_1.json new file mode 100644 index 0000000000000000000000000000000000000000..37d482c7b21e2b3b9fd071d17c3fee4c31fbcfcd --- /dev/null +++ b/438/TumorCenter_CD8_block14_x4_y5_patient438_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13243.0, + "Centroid Y µm": 13093.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/438/history_text.txt b/438/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/438/icd_codes.txt b/438/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..accf3dcd8d4de5cd9bc4bf83cd37a7f3c726fcc9 --- /dev/null +++ b/438/icd_codes.txt @@ -0,0 +1 @@ +Zungenrandkarzinom[C02.1 L] \ No newline at end of file diff --git a/438/ops_codes.txt b/438/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..8419932765fcfdb5b765aa216bc8fea9dd96530d --- /dev/null +++ b/438/ops_codes.txt @@ -0,0 +1 @@ +Transorale Hemiglossektomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Temporäre Tracheotomie[5-311.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ] Spalthaut auf granulierendes Hautareal großflächig Empfängerstelle Unterarm[5-902.58 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Wechsel eines vaskulären Implantates[5-394.3 ] Exstirpation Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 L] Direkte diagnostische Pharyngoskopie[1-611.0 ] \ No newline at end of file diff --git a/438/patient_clinical_data.json b/438/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..866389bfa6c524d36f8ae7bd27e432b08cb0d8fe --- /dev/null +++ b/438/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2017, + "age_at_initial_diagnosis": 67, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 28, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + carboplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/438/patient_pathological_data.json b/438/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..69c10595e8b4bbdc3c573ee319dbab7f4884b0b4 --- /dev/null +++ b/438/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "438", + "primary_tumor_site": "Oral_Cavity", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 79, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 14.0 +} \ No newline at end of file diff --git a/438/surgery_description.txt b/438/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..6040c9f444fefb3ffb6e2380dbbe7aac164d886b --- /dev/null +++ b/438/surgery_description.txt @@ -0,0 +1 @@ +Transoral tumor resection, Modified radical neck dissection diff --git a/438/surgery_report.txt b/438/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..e5c7cc163c0a598b333ce1131e4927b4a837ed5e --- /dev/null +++ b/438/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia and intubation transnasally by the anesthesia colleagues. Then sterile washing and draping of the neck area and performance of a tracheostomy. Vertical skin incision for this. Exposure of the musculature, exposure of the thyroid isthmus. Dissection of the thyroid isthmus. Exposure of the anterior tracheal wall and insertion between the 2nd and 3rd tracheal ring and intubation onto an LE tube. Then placement of a PEG by Dr. and . For this, insertion with the flexible esophagoscope and endoscopy into the stomach. If diaphanoscopy is good, perform the PEG insertion using the thread pull-through method. Then positioning of the patient, sterile washing and draping and start with tumor resection by . Use a 10 watt diode laser for this and cut around the tumor with a safety margin of 1-1.5 cm. The resection is relatively scarce in the area of the wound bed, therefore a resection is performed here, all edge samples are tumor-free in the frozen section. Neck dissection is then carried out by on the left side: enter with the 15 mm scalpel and make a skin incision along the anterior edge of the sternocleidomastoid muscle and from the mastoid to the caudal side in a curved line along the anterior edge of the sternocleidomastoid muscle. Sharp cutting of the skin. Subcutaneous tissue and platysma. The external jugular vein is exposed, ligated and cut. The platysmal flap is now dissected with a scalpel. Dissection along the anterior edge of the sternocleidomastoid muscle in depth. The accessory nerve is now exposed and spared. The accessory nerve is followed in a cranial direction. The posterior belly of the digastric muscle can now also be seen, traced further medially. Further medially, the submandibular gland can be seen, which is also easily visualized. The omohyoid muscle is visible caudally and the cervical vascular sheath is visible in the depth below the neck preparation. The internal jugular vein is dissected from caudal to cranial. There is no injury to the structures here. The superior thyroid vein and facial vein are dissected and spared. Medial to the jugular vein, the common carotid artery and the external carotid artery are exposed as well as the vagus nerve and the cervical artery are now dissected in level IIb with detachment of the neck preparation. Level IIa follows, sparing the accessorius nerve. Levels III, IV and V are also detached without difficulty. The plexus branches are exposed and spared. No chyle fistula occurs caudally when the neck preparation is removed. The anterior neck preparation is now also exposed and dissected along the V. facialis and the V. thyroidea superior. Neck dissection on the right side of : The surgeon repositions the patient in the lateral head position to the left. Make a skin incision on the anterior edge of the sternocleidomastoid muscle, from the mastoid to the lateral edge of the tracheostoma. Make sure to leave a sufficient skin bridge between the skin incision and the tracheostoma. Separation of the subcutaneous tissue. Separation of the platysma. Protection of the external jugular vein and the auricular nerve. Subplatysmal dissection cranially and caudally and exposure of the submandibular gland. Exposure of the posterior venter of the digastric muscle. Exposure of the omohyoid muscle. Insertion of a retractor between the omohyoid and sternocleidomastoid muscles caudally and a retractor under the digastric muscle. Exposure of the anterior border of the sternocleidomastoid muscle and dissection along the muscle in depth until the cervical plexus is exposed. Identification of the accessorius nerve and gentle dissection along the nerve to free the neck preparation from the nerve. The nerve can be completely preserved. Exposure of the internal jugular vein and dissection along the vein from caudal to cranial, dividing the neck preparation into a medial and a lateral part. Removal of the lateral part from cranial to caudal with bipolar coagulation of smaller blood vessels. All vascular and nerve structures can be preserved. Approach to the medial neck preparation. Separation of the neck preparation from the vessels. Release of the submandibular gland. Exposure of the hypoglossal nerve. The hypoglossal nerve can be safely spared. Removal of the medial part of the lymph nodes. Exposure of the bifurcation of the common carotid artery. Exposure of the branches of the external carotid artery. The superior thyroid artery is conditioned for flap anastomosis. Additional conditioning of three branches or three branches of the facial vein for the anastomosis. Completion of the neck dissection on the right side without complications. Then lifting of the radialis graft through and . Incision of the skin 11 x 8 cm, visualization of the venous situation in the elbow. Depiction of the V. cephalica, the V. basilica and the venous confluence. Exposure of the brachioradialis muscle. Visualization of the superficial ramus, radial nerve, visualization of the radial artery. Underbinding of the radial artery, lifting of the graft from the tendons and preparation of the vascular pedicle. The radialis graft is then removed and the graft is inserted transorally in the area of the defect. The submandibular gland was removed on the left side. Prior to this, a tunnel was created through by cutting the digastric muscle and creating a tunnel that encompasses 3 QF. The stalk was pulled through this tunnel and then transferred to the opposite side and connected to the superior thyroid artery, the facial artery, an outlet from the facial artery and another deeper outlet from the internal jugular vein, so that we have 3 venous vascular anastomoses and one arterial anastomosis. The graft is very well supplied with blood. Redon drainage tubes are inserted and the wound is closed in two layers. The patient goes to the intensive care unit intubated via the tracheostoma. Please continue flap control according to the usual schedule and antibiotics for 24 hours. \ No newline at end of file diff --git a/439/InvasionFront_CD3_block8_x3_y4_patient439_0.json b/439/InvasionFront_CD3_block8_x3_y4_patient439_0.json new file mode 100644 index 0000000000000000000000000000000000000000..85ca41c00b04b5025df72fce0fd33f6a9bdff616 --- /dev/null +++ b/439/InvasionFront_CD3_block8_x3_y4_patient439_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11119.1, + "Centroid Y µm": 20139.3, + "Num Detections": 23265, + "Num Negative": 22043, + "Num Positive": 1222, + "Positive %": 5.253, + "Num Positive per mm^2": 524.11 + } +} \ No newline at end of file diff --git a/439/InvasionFront_CD3_block8_x4_y4_patient439_1.json b/439/InvasionFront_CD3_block8_x4_y4_patient439_1.json new file mode 100644 index 0000000000000000000000000000000000000000..55ef7c1bd998da96eef7578d1411b0014387c759 --- /dev/null +++ b/439/InvasionFront_CD3_block8_x4_y4_patient439_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13567.8, + "Centroid Y µm": 20214.3, + "Num Detections": 17633, + "Num Negative": 16419, + "Num Positive": 1214, + "Positive %": 6.885, + "Num Positive per mm^2": 498.16 + } +} \ No newline at end of file diff --git a/439/InvasionFront_CD8_block8_x3_y4_patient439_0.json b/439/InvasionFront_CD8_block8_x3_y4_patient439_0.json new file mode 100644 index 0000000000000000000000000000000000000000..51e53bf7edecfdd9a28e507dc1fa75288152f5fd --- /dev/null +++ b/439/InvasionFront_CD8_block8_x3_y4_patient439_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 12043.6, + "Centroid Y µm": 10194.6, + "Num Detections": 18463, + "Num Negative": 17310, + "Num Positive": 1153, + "Positive %": 6.245, + "Num Positive per mm^2": 492.43 + } +} \ No newline at end of file diff --git a/439/InvasionFront_CD8_block8_x4_y4_patient439_1.json b/439/InvasionFront_CD8_block8_x4_y4_patient439_1.json new file mode 100644 index 0000000000000000000000000000000000000000..aec2d0c9cabe18cc78a0c3f61ea6cb33ea55288e --- /dev/null +++ b/439/InvasionFront_CD8_block8_x4_y4_patient439_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14517.3, + "Centroid Y µm": 10319.5, + "Num Detections": 15983, + "Num Negative": 14530, + "Num Positive": 1453, + "Positive %": 9.091, + "Num Positive per mm^2": 589.37 + } +} \ No newline at end of file diff --git a/439/TumorCenter_CD3_block8_x3_y4_patient439_0.json b/439/TumorCenter_CD3_block8_x3_y4_patient439_0.json new file mode 100644 index 0000000000000000000000000000000000000000..968b6df6964f0ac5806d522eb1eed68d426a50d0 --- /dev/null +++ b/439/TumorCenter_CD3_block8_x3_y4_patient439_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11267.4, + "Centroid Y µm": 11116.7, + "Num Detections": 15090, + "Num Negative": 13901, + "Num Positive": 1189, + "Positive %": 7.879, + "Num Positive per mm^2": 646.71 + } +} \ No newline at end of file diff --git a/439/TumorCenter_CD3_block8_x4_y4_patient439_1.json b/439/TumorCenter_CD3_block8_x4_y4_patient439_1.json new file mode 100644 index 0000000000000000000000000000000000000000..56bb1aac7a4795d0ba3073b50ca0c624b65a17b1 --- /dev/null +++ b/439/TumorCenter_CD3_block8_x4_y4_patient439_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13717.7, + "Centroid Y µm": 10794.3, + "Num Detections": 20351, + "Num Negative": 18965, + "Num Positive": 1386, + "Positive %": 6.81, + "Num Positive per mm^2": 556.19 + } +} \ No newline at end of file diff --git a/439/TumorCenter_CD8_block8_x3_y4_patient439_0.json b/439/TumorCenter_CD8_block8_x3_y4_patient439_0.json new file mode 100644 index 0000000000000000000000000000000000000000..f02cf890de41fa487a9a4ae8e24bc5525477e6f4 --- /dev/null +++ b/439/TumorCenter_CD8_block8_x3_y4_patient439_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11344.0, + "Centroid Y µm": 10719.3, + "Num Detections": 23502, + "Num Negative": 22868, + "Num Positive": 634, + "Positive %": 2.698, + "Num Positive per mm^2": 252.22 + } +} \ No newline at end of file diff --git a/439/TumorCenter_CD8_block8_x4_y4_patient439_1.json b/439/TumorCenter_CD8_block8_x4_y4_patient439_1.json new file mode 100644 index 0000000000000000000000000000000000000000..3495b2d404b5e52214537fd861af5bced41c6ae0 --- /dev/null +++ b/439/TumorCenter_CD8_block8_x4_y4_patient439_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13942.6, + "Centroid Y µm": 10519.4, + "Num Detections": 20749, + "Num Negative": 19821, + "Num Positive": 928, + "Positive %": 4.473, + "Num Positive per mm^2": 375.22 + } +} \ No newline at end of file diff --git a/439/history_text.txt b/439/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a004fcb1d077ac36e0639baa0ed30aa0df0a89b7 --- /dev/null +++ b/439/history_text.txt @@ -0,0 +1 @@ +A cT2 cN2b oropharyngeal carcinoma on the right side was histologically confirmed in the patient during a panendoscopy <2013>. A moderately differentiated squamous cell carcinoma without HPV association was found. In our interdisciplinary tumor conference, primary surgical treatment was indicated. CT showed no evidence of distant metastasis, no evidence of osseous infiltration. \ No newline at end of file diff --git a/439/icd_codes.txt b/439/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..56e8af9f7fbe98d9f2e21040234879d89c1804f5 --- /dev/null +++ b/439/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] \ No newline at end of file diff --git a/439/ops_codes.txt b/439/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..5bbf534f1c09837bd28d1aeeb44c04d6eda72a2c --- /dev/null +++ b/439/ops_codes.txt @@ -0,0 +1 @@ +Transorale partielle Resektion des Pharynx mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.04 ] Partielle Resektion des Pharynx durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-295.14 ] Sonstige Entnahme und Transplantation sonstiges Transplantat mit mikrovaskuläre Anastomosierung Unterarm[5-858.x3 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 L] Entnahme von Vollhaut in der Leistenregion[5-901.1c ] Vollhaut großflächig Empfängerstelle Unterarm[5-902.68 R] Kontinuierliche Sogbehandlung mit Pumpensystem bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.20 ] Wechsel vaskuläres Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Permanente Tracheotomie[5-312.0 ] \ No newline at end of file diff --git a/439/patient_clinical_data.json b/439/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..6f93d522f1c3abfd1d26c8a6def763f5101a4f24 --- /dev/null +++ b/439/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 41, + "sex": "male", + "smoking_status": "smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 34, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/439/patient_pathological_data.json b/439/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..f7c152674caaa3bad92ce4a9395d083997fdc1e9 --- /dev/null +++ b/439/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "439", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "negative", + "number_of_positive_lymph_nodes": 3.0, + "number_of_resected_lymph_nodes": 35, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "yes", + "perineural_invasion_Pn": "yes", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "<0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": 25.0 +} \ No newline at end of file diff --git a/439/surgery_description.txt b/439/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..966db5f37dd68e77c4b9dd05b8e5dbbe929a7d50 --- /dev/null +++ b/439/surgery_description.txt @@ -0,0 +1 @@ +Tumor resection, Bilateral neck dissection, Defect reconstruction, Free flap (Radial) diff --git a/439/surgery_report.txt b/439/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..ff78ae333e54a7af61fc94429b3e1757083872c2 --- /dev/null +++ b/439/surgery_report.txt @@ -0,0 +1 @@ +After preparation and intubation by the anesthesia colleagues, a pharyngo-laryngoscopy was performed to determine the current extent of the tumor. A coarse exulcerated tumor of the right tonsillar lobe was found, here coarsely seated and not displaceable. Infiltration of the soft palate also submucosal to parauvular on the right. Growth up to the dorsal maxilla. Growth circumscribed to the alveolar ridge. Growth to buccal over the glossotonsillar groove and the posterior floor of the mouth. Infiltration of the edge of the tongue and also the base of the tongue, here about Ľ infiltrated. Posterior palatal arch is reached. Also the caudal, former tonsil pole. No further tumor growth further caudally. Ultrasonography shows a cN2b neck status with infiltration of the internal jugular vein. The tumor is now resected transorally. Incision of the tumor with a safety margin of a good 1 cm and subtotal removal of the soft palate. Resection up to the left tonsil lobe. Subtotal removal of the soft palate. Resection up to the cheek. Exposure of the maxillary bone. Removal of the last gingival pocket and thus pushing the tumor away from the maxilla, which is growing close here, but certainly not breaking through the periosteum. The same procedure is now performed on the mandibular branch via the buccal side. View of the ascending mandibular branch. The tumor grows here, but does not reach the periosteum. From the inside, pushing off the periosteum in the posterior region. Close growth to the periosteum. Here the entire periosteum is pushed away from the posterior mandible, resulting in a good solution. A clear infiltration of the pharyngeal musculature can now be seen in depth. This is resected subtotally. Growth up to the pterygoid musculature. Circumscribed infiltration here. Overall, however, good mobilization of the tumour, so that the tumour can be mobilized cranially after detachment of the musculature with a clear safety margin. Resection of the posterior floor of the mouth and the edge of the tongue, maintaining a safety margin of 1 ˝ cm in the area of the tongue. Removal of the tumor in the area of the tongue down to the base of the tongue. It can now be seen that the tumor has broken through to the cervical region via the posterior floor of the mouth and laterally via the base of the tongue. Partial infiltration of the submandibular gland, which is already visualized enorally. Exposure of the lingual nerve, which is broad anteriorly but clearly infiltrated by the tumor dorsally. This is later removed. Due to the growth, the decision was made to proceed with a combined procedure and further transcervical resection. Therefore, repositioning for neck dissection of the right side. Curved skin incision on the anterior edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Exposure and dissection of the platysma. Exposure of the sternocleidomastoid muscle with careful preservation of the extremely strong external jugular vein. A clear infiltration of the muscle by the metastasis located in level II can already be seen in the upper area of the sternocleidomastoid muscle. Clear infiltration. Now caudal visualization of the entire sternocleidomastoid muscle. Exposure of the omohyoid muscle. Separation of the sternocleidomastoid muscle and cranial dissection. A markedly coarsely growing mass is seen in levels II and III, with a structure that most closely resembles a soft tissue metastasis. The internal jugular vein is now visualized. Cranial dissection. The vein is also clearly infiltrated in the middle area. The vein is therefore removed after securing the common carotid artery and the vagus nerve. Cranial dissection. The accessor nerve can be found below the trapezius muscle, but is clearly infiltrated medially and is also resected later. The metastasis grows close to the carotid bulb. The superior thyroid artery can be secured. The lingual artery must be removed later if the tumor grows, as must the facial artery. Careful dissection in the area of the bulb. Exposure of the hypoglossal nerve. Careful dissection of the nerve, the carotid bulb and the hypoglossal nerve can be preserved at the end. Securing the internal carotid artery. Certainly no tumor growth here, the rest of the external carotid artery is again free. A small tumor cone can now be dissected on the carotid artery in the direction of the primary tumor. Careful release of the cone. Removal of all surrounding tissue. Cranial removal of the internal jugular vein. The tumor cone can be followed towards the posterior floor of the mouth. Release of the submandibular gland, which is not infiltrated in the caudal part. Perform the pharyngotomy via the extirpation of the submandibular gland. Extend the pharyngotomy and complete the tumor resection, including the infiltrated floor of the mouth, and include the base of the tongue, resecting a good 1/3 of the base of the tongue. Overall, there is a clear breakthrough into the muscles of the floor of the mouth via the base of the tongue and the posterior floor of the mouth, resulting in a cT4a finding. The entire tumor specimen is thread-marked in toto with adjacent soft tissue metastasis for definitive histology. Enorally, all mucosal margins are provided with margin samples. This shows an R0 resection for the invasive carcinoma on all sides. Only the area of the floor of the mouth shows circumscribed CIS. Therefore, a generous resection and a new margin sample were performed here. Here, too, CIS was suspected, so that after a further resection a final specimen was taken, which was then assessed in the frozen section as completely free of tumor and dysplasia, so that overall an R0 resection with extensive growing cT4a oropharyngeal carcinoma with breakthrough and metastasis per continuitatem in the soft tissues of the neck can be assumed. The neck dissection is now completed. This involves clearing out level V while carefully sparing the cervical plexus branches. Also clear and complete level I b. Here too, several nodes measuring up to just under 2 cm. If the wound is dry, neck dissection of the left side and elevation of the radialis graft from the right forearm are now performed in parallel. Neck dissection of the left side. To do this, make a curved skin incision on the front edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Exposure and transection of the platysma. Exposure of the sternocleidomastoid muscle. Exposure and preservation of the external jugular vein. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Dissection of the anterior neck preparation with careful protection of the superior thyroid artery, the cervical artery and the hypoglossal nerve. Dissection of the internal jugular vein. This shows a macroscopically suspicious mass in the jugulofacial angle, but without infiltration of the surrounding tissue. Exposure of the accessorius nerve. Excision of the accessorius triangle with careful protection of the nerve and excision of level V with careful protection of the cervical plexus branches. Final wound inspection. In dry conditions, wound irrigation with Ringer's solution and in dry wound conditions, insertion of a 10 Redon drain and careful, two-layer wound closure. Now to elevate the radialis graft. After marking the graft measuring up to 13 x 10 cm in total with a special configuration for the base of the tongue, floor of the mouth and soft palate. Creation of the tourniquet. Trimming of the graft. First radial preparation. This shows that the cephalic vein lies very far dorsally in the area of origin and is not in contact with the graft over a long distance, so that the cephalic vein does not need to be included. Exposure of the superficial radial nerve ramus, which can be completely spared. Exposure of the brachioradialis muscle. Exposure of the distal vascular pedicle. Dissection of the vascular pedicle. Ulnar dissection. Strictly subfascial release of the graft, leaving the peritendineum intact. Subsequent cranial dissection of the pedicle utilizing the entire pedicle position and left-sided anastomosis. A strong venous confluence can be seen here. Reopening of the tourniquet. A properly perfused graft is visible. Careful hemostasis and later removal of the graft after ligation of the vessel leading to ................ Subsequently, with dry wound conditions, careful, two-layer wound closure and harvesting of the full-thickness skin graft taken from the right groin. The vacuum pump is then applied and the Kramer splint is placed in the functional position. Removal of the full-thickness skin graft. To do this, cut around an area measuring 16 x 7.5 cm in total. Wider lifting is not possible due to increased skin tension. Incision of the graft. Strictly cutaneous lifting. Subcutaneous mobilization down to the fascia lata and the abdominal fascia. Subsequent insertion of a 10 Redon drain in dry wound conditions and multi-layer, subcutaneous wound closure and skin suturing. To incorporate the graft. For this purpose, combined transoral and transcervical suturing is performed using partially placed sutures. Difficult suturing conditions in the upper and lower jaw area. However, overall good fit, especially in the area of the caudal pharynx and the base of the tongue. Resection extending into the vallecula. Overall adequate fit here. In the meantime, the tracheotomy was performed. Horizontal skin incision at the level of the cricoid cartilage. Cut through the skin and subcutaneous tissue. Exposure and transection of the infrahyoid musculature. Exposure of the cricoid cartilage. Exposure of the anterior surface of the trachea. Dissection of the thyroid isthmus. Insertion between the 2nd and 3rd tracheal ring. Creation of a broad-based pedicled Björk flap and incision of the tracheostoma in the typical manner. Subsequently, transfer to a size 8 low-cuff cannula, which is suture-fixed. The cervical vessels are now prepared. The lingual artery is no longer sufficiently pervious or has an inadequate flow after the tube is removed, so the superior thyroid artery is now prepared. Excellent flow here. Preparation of the graft vessels. Then perform the arterial anastomosis with 8-0 Ethilon. This works relatively well even with unequal vessel calibers. Good adaptation. After reopening the blood flow, regular venous return flow and good pedicle pulsation immediately. Now prepare the external jugular vein. This is seen cranially with a questionably discrete thrombus. Open the vein. After removing a small amount of thrombotic material, excellent reflux, so that after measuring a size 3.0 coupler, anastomosis is performed with the coupler system. Subsequent regular circulation. Positive spreading phenomenon and regular pedicle pulsation as well as regular graft perfusion, so that after final wound inspection and wound irrigation with Ringer's solution, insertion of a 10 Redon drain and subsequent careful, two-layer wound closure. Final inspection of the graft and, if the graft is vital, termination of the procedure at this point. Conclusion: Intraoperatively R0-resected, extremely aggressive growing cT4a cN2c oropharyngeal carcinoma with perifocal CIS and metastasis per continuitatem in the soft tissues of the neck. Due to the resected surrounding musculature, a prolonged recovery of swallowing function can be expected. If the graft heals properly, the first clinical swallowing diagnostics can be carried out from the 9th postoperative day, followed by a diet if necessary. Due to tumor growth, adjuvant radiochemotherapy is urgently indicated. \ No newline at end of file diff --git a/440/InvasionFront_CD3_block8_x1_y4_patient440_0.json b/440/InvasionFront_CD3_block8_x1_y4_patient440_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4247b1aa03221edf0e39ce3db39f2ad063f45196 --- /dev/null +++ b/440/InvasionFront_CD3_block8_x1_y4_patient440_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3598.1, + "Centroid Y µm": 20414.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/InvasionFront_CD3_block8_x2_y4_patient440_1.json b/440/InvasionFront_CD3_block8_x2_y4_patient440_1.json new file mode 100644 index 0000000000000000000000000000000000000000..0777ad6645a4ddef48411127fc053f1b23b992a2 --- /dev/null +++ b/440/InvasionFront_CD3_block8_x2_y4_patient440_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6296.7, + "Centroid Y µm": 20364.2, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/InvasionFront_CD8_block8_x1_y4_patient440_0.json b/440/InvasionFront_CD8_block8_x1_y4_patient440_0.json new file mode 100644 index 0000000000000000000000000000000000000000..e2bf46e41f60d39ac192bf11896fc6810bd3d7f4 --- /dev/null +++ b/440/InvasionFront_CD8_block8_x1_y4_patient440_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4472.6, + "Centroid Y µm": 9569.9, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/InvasionFront_CD8_block8_x2_y4_patient440_1.json b/440/InvasionFront_CD8_block8_x2_y4_patient440_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f51dad551b35e4a286744589532e5d8ee324d771 --- /dev/null +++ b/440/InvasionFront_CD8_block8_x2_y4_patient440_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 7071.3, + "Centroid Y µm": 9769.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/TumorCenter_CD3_block8_x1_y4_patient440_0.json b/440/TumorCenter_CD3_block8_x1_y4_patient440_0.json new file mode 100644 index 0000000000000000000000000000000000000000..40c9d7214b19ef4ae26f452bfe61ef926b4035c7 --- /dev/null +++ b/440/TumorCenter_CD3_block8_x1_y4_patient440_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 4097.8, + "Centroid Y µm": 12093.6, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/TumorCenter_CD3_block8_x2_y4_patient440_1.json b/440/TumorCenter_CD3_block8_x2_y4_patient440_1.json new file mode 100644 index 0000000000000000000000000000000000000000..55c81481f88933ee7c875510b236ec07b5b81c55 --- /dev/null +++ b/440/TumorCenter_CD3_block8_x2_y4_patient440_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6596.5, + "Centroid Y µm": 11768.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/TumorCenter_CD8_block8_x1_y4_patient440_0.json b/440/TumorCenter_CD8_block8_x1_y4_patient440_0.json new file mode 100644 index 0000000000000000000000000000000000000000..707e2e73f331b66d823bc4daea3e8fe3fe2f09a7 --- /dev/null +++ b/440/TumorCenter_CD8_block8_x1_y4_patient440_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 3922.9, + "Centroid Y µm": 11294.0, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/TumorCenter_CD8_block8_x2_y4_patient440_1.json b/440/TumorCenter_CD8_block8_x2_y4_patient440_1.json new file mode 100644 index 0000000000000000000000000000000000000000..6df5346d8fa1ef12d2a68d4efa58f0365b22e932 --- /dev/null +++ b/440/TumorCenter_CD8_block8_x2_y4_patient440_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 6496.6, + "Centroid Y µm": 11094.1, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/440/history_text.txt b/440/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..a2afac64235c7958b5f462fc0bda0f8d62e6d232 --- /dev/null +++ b/440/history_text.txt @@ -0,0 +1 @@ +The patient has had dysphagia and a progressive cervical mass on the right since <2012>. In the panendoscopy performed <2013>, no primary for the cervical lymph node metastasis on the right could be seen, whereupon a PET-CT was performed. This revealed a tumor-specific mass in the area of the right tonsil. In addition, several conspicuous mediastinal lymph nodes and also highly suspicious cervical lymph nodes on the left. Hence the indication for the above-mentioned procedure. The course of the operation and the neck dissection on the left side were previously discussed with . \ No newline at end of file diff --git a/440/icd_codes.txt b/440/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..e3dca6ce6d546b02f87f7a4fe8fab89f934a14ea --- /dev/null +++ b/440/icd_codes.txt @@ -0,0 +1 @@ +Rachenmandelkarzinom[C11.1 ] \ No newline at end of file diff --git a/440/ops_codes.txt b/440/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..2409540025a8075e8fe3ed41a6b47aead227547c --- /dev/null +++ b/440/ops_codes.txt @@ -0,0 +1 @@ +Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 4 Regionen[5-403.10 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 4 Regionen[5-403.20 R] \ No newline at end of file diff --git a/440/patient_clinical_data.json b/440/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..528e5af604f959095cd6ad1fd215c0e4f129d10f --- /dev/null +++ b/440/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 79, + "sex": "male", + "smoking_status": null, + "primarily_metastasis": "no", + "survival_status": "deceased", + "survival_status_with_cause": "deceased", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 69, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "no", + "adjuvant_systemic_therapy_modality": null, + "adjuvant_radiochemotherapy": "no" +} \ No newline at end of file diff --git a/440/patient_pathological_data.json b/440/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..b6ab8e1447ac123d361d735e44b57307aab016e8 --- /dev/null +++ b/440/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "440", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT1", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 1.0, + "number_of_resected_lymph_nodes": 31, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.5", + "histologic_type": "SCC_Conventional-NonKeratinizing", + "infiltration_depth_in_mm": 8.0 +} \ No newline at end of file diff --git a/440/surgery_description.txt b/440/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..08d85673b01515fc57859ca32154afeb912e133b --- /dev/null +++ b/440/surgery_description.txt @@ -0,0 +1 @@ +Tumor tonsillectomy, Radical neck dissection diff --git a/440/surgery_report.txt b/440/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..bf5940b8a0f6d5f6b8df2d9becfcffb776fc3433 --- /dev/null +++ b/440/surgery_report.txt @@ -0,0 +1 @@ +Induction of anesthesia by the anesthesiologist. Nasal intubation by the anesthetist. Insertion of the tonsil blocker and inspection of the tonsil boxes. The tonsil lobe on the left side looks completely unremarkable, on the right side a rough mass of approx. 1 to 2 cm can be felt. It is therefore decided to resect the right tonsil with a sufficient safety margin. Incision of the mucosa with the monopolar needle, then change to the scissors. Dissection of the mass, taking the entire tonsil with the dissection technique using scissors and bipolar forceps. The specimen is thread-marked for histology. The frozen section shows a T1 squamous cell carcinoma, which was completely resected in sano. Modified radical neck dissection on the left (): Initially skin spray disinfection. Infiltration anesthesia along the anterior border of the sternocleidomastoid muscle. Abjoration of the skin and sterile draping. Creation of a skin incision along the anterior border of the sternocleidomastoid muscle. Cut through the subcutaneous tissue and the platysma. Exposure of the anterior border of the sternocleidomastoid muscle. Exposure of the accessorius nerve. Dissection of the same in an anterior cranial direction. Exposure of the digaster muscle. Exposure of the omohyoid muscle. Subsequent successive dissection along the internal jugular vein. Exposure of the vagus nerve and the common carotid artery. Development of the neck preparation from cranial to caudal. In the area of region II b, a large, coarse mass with a maximum diameter of approx. 2 cm with a clear suspicion of metastasis is visible. Exposure and sparing of the branches of the cervical plexus. Exposure and sparing of the hypoglossal nerve and the superficial cervical nerve. Subsequent dissection of the anterior cervical vascular sheath and removal of the anterior neck specimen. Hemostasis using bipolar coagulation. Wound irrigation using hydrogen peroxide and Ringer's solution. Repeated wound inspection. Completely dry conditions. Placement of a 10 Redon drain. Two-layer wound closure and completion of the neck dissection on the left side without complications. Neck dissection on the right side: The large N3 neck metastasis is located here, it comprises levels II to IV and palpatorily also level V. Sonographically, the sternocleidomastoid muscle and the internal jugular vein are infiltrated and can no longer be delimited. First skin incision and creation of a platysmal flap. Exposure of the sternocleidomastoid muscle. It can be clearly seen that the tumor completely infiltrates the muscle in the middle area as well as in the upper area where the accessorius nerve enters the muscle. The sternocleidomastoid muscle is set off at the lower edge. It can also be seen that the jugular vein runs through the tumor and is already completely thrombosed. The vein is cut off at the lower edge and removed. Exposure of the common carotid artery, which can be pushed away from the tumor, and dissection of the neck metastasis cranially. The upper area shows that the facial artery and the facial vein are also infiltrated; unfortunately, these must also be removed. Further triggering of the metastasis. After visualization of the posterior abdomen of the digaster, the hypoglossal nerve was also found to be infiltrated. After intraoperative consultation with , this is resected together with the tumor conglomerate. Now complete dissection of the internal carotid artery. It becomes clear that the external carotid artery is also infiltrated. The external carotid artery is removed after the superior thyroid artery has been removed and ligated. The metastasis can be retrieved in its entirety. Then complete the neck dissection in level V, sparing the remaining plexus branches. A few smaller lymph nodes could still be retrieved here. Clearing out the remaining level II b. Level I b and the submandibular gland can be preserved. The external jugular vein could also be preserved, although it is very thin. Conclusion: cT1 cN3 tonsillar carcinoma on the right, resected in sano according to the frozen section. On the right side, the following structures were removed by tumor infiltration: sternocleidomastoid muscle, internal jugular vein, external carotid artery, accessorius nerve, hypoglossal nerve. After receiving the final histology, the patient should be presented at the tumor conference to discuss adjuvant radiochemotherapy or radiotherapy, also with regard to the conspicuous mediastinal and hilar lymph nodes. \ No newline at end of file diff --git a/441/InvasionFront_CD3_block13_x5_y1_patient441_0.json b/441/InvasionFront_CD3_block13_x5_y1_patient441_0.json new file mode 100644 index 0000000000000000000000000000000000000000..7286cc7a01da1cb5e60f3fa344be063aaae3360a --- /dev/null +++ b/441/InvasionFront_CD3_block13_x5_y1_patient441_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15741.7, + "Centroid Y µm": 2173.8, + "Num Detections": 0, + "Num Negative": 0, + "Num Positive": 0, + "Positive %": NaN, + "Num Positive per mm^2": NaN + } +} \ No newline at end of file diff --git a/441/InvasionFront_CD3_block13_x6_y1_patient441_1.json b/441/InvasionFront_CD3_block13_x6_y1_patient441_1.json new file mode 100644 index 0000000000000000000000000000000000000000..bb860aa5523f5a457a5854922f2d5309813b4c10 --- /dev/null +++ b/441/InvasionFront_CD3_block13_x6_y1_patient441_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 18440.2, + "Centroid Y µm": 2148.9, + "Num Detections": 15095, + "Num Negative": 14294, + "Num Positive": 801, + "Positive %": 5.306, + "Num Positive per mm^2": 456.73 + } +} \ No newline at end of file diff --git a/441/InvasionFront_CD8_block13_x5_y1_patient441_0.json b/441/InvasionFront_CD8_block13_x5_y1_patient441_0.json new file mode 100644 index 0000000000000000000000000000000000000000..b76177f032490420ad4b89b2e17ad8489db03080 --- /dev/null +++ b/441/InvasionFront_CD8_block13_x5_y1_patient441_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17565.7, + "Centroid Y µm": 3897.9, + "Num Detections": 2580, + "Num Negative": 2520, + "Num Positive": 60, + "Positive %": 2.326, + "Num Positive per mm^2": 146.22 + } +} \ No newline at end of file diff --git a/441/InvasionFront_CD8_block13_x6_y1_patient441_1.json b/441/InvasionFront_CD8_block13_x6_y1_patient441_1.json new file mode 100644 index 0000000000000000000000000000000000000000..b9c7d26f7c2fe37a1fd5d54951210d21919f2f6e --- /dev/null +++ b/441/InvasionFront_CD8_block13_x6_y1_patient441_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20364.2, + "Centroid Y µm": 3798.0, + "Num Detections": 15732, + "Num Negative": 14712, + "Num Positive": 1020, + "Positive %": 6.484, + "Num Positive per mm^2": 548.82 + } +} \ No newline at end of file diff --git a/441/TumorCenter_CD3_block13_x5_y1_patient441_0.json b/441/TumorCenter_CD3_block13_x5_y1_patient441_0.json new file mode 100644 index 0000000000000000000000000000000000000000..4d2b119028c87ec694d6e118b53bccc05d299542 --- /dev/null +++ b/441/TumorCenter_CD3_block13_x5_y1_patient441_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17840.6, + "Centroid Y µm": 9370.0, + "Num Detections": 17069, + "Num Negative": 16646, + "Num Positive": 423, + "Positive %": 2.478, + "Num Positive per mm^2": 215.94 + } +} \ No newline at end of file diff --git a/441/TumorCenter_CD3_block13_x6_y1_patient441_1.json b/441/TumorCenter_CD3_block13_x6_y1_patient441_1.json new file mode 100644 index 0000000000000000000000000000000000000000..2b0ca102d864f957a5edffafcf79b81834396c58 --- /dev/null +++ b/441/TumorCenter_CD3_block13_x6_y1_patient441_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 20214.3, + "Centroid Y µm": 9470.0, + "Num Detections": 16624, + "Num Negative": 15314, + "Num Positive": 1310, + "Positive %": 7.88, + "Num Positive per mm^2": 663.32 + } +} \ No newline at end of file diff --git a/441/TumorCenter_CD8_block13_x5_y1_patient441_0.json b/441/TumorCenter_CD8_block13_x5_y1_patient441_0.json new file mode 100644 index 0000000000000000000000000000000000000000..41f726b3be72d8eb6d4e19f7ce537bf7065c1f2d --- /dev/null +++ b/441/TumorCenter_CD8_block13_x5_y1_patient441_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15067.0, + "Centroid Y µm": 2648.6, + "Num Detections": 13778, + "Num Negative": 13511, + "Num Positive": 267, + "Positive %": 1.938, + "Num Positive per mm^2": 139.91 + } +} \ No newline at end of file diff --git a/441/TumorCenter_CD8_block13_x6_y1_patient441_1.json b/441/TumorCenter_CD8_block13_x6_y1_patient441_1.json new file mode 100644 index 0000000000000000000000000000000000000000..f6358bdfccc33b1284f7fe063876b180c738a56a --- /dev/null +++ b/441/TumorCenter_CD8_block13_x6_y1_patient441_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 17390.8, + "Centroid Y µm": 2323.8, + "Num Detections": 15663, + "Num Negative": 15014, + "Num Positive": 649, + "Positive %": 4.144, + "Num Positive per mm^2": 336.88 + } +} \ No newline at end of file diff --git a/441/history_text.txt b/441/history_text.txt new file mode 100644 index 0000000000000000000000000000000000000000..7183adb9065333d40fd1eb23c4171bef3731bdd2 --- /dev/null +++ b/441/history_text.txt @@ -0,0 +1 @@ +Patient with histologically confirmed cT4a hypopharyngeal carcinoma with invasion into the right larynx with thyroid cartilage invasion. The above-mentioned surgery was therefore indicated. \ No newline at end of file diff --git a/441/icd_codes.txt b/441/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..59929bd1c063737e1625754ffe5897d700b08efe --- /dev/null +++ b/441/icd_codes.txt @@ -0,0 +1 @@ +Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ] Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 ] \ No newline at end of file diff --git a/441/ops_codes.txt b/441/ops_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..35e0b969f71803962dd4706389b6ccc7b13c62b1 --- /dev/null +++ b/441/ops_codes.txt @@ -0,0 +1 @@ +Laryngektomie mit Pharyngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.11 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 5 Regionen[5-403.04 B] Endoskopische pharyngozervikale Ösophagomyotomie[5-420.16 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] \ No newline at end of file diff --git a/441/patient_clinical_data.json b/441/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..25378346b7d34fc5e58ba45ee640f6cbc329494d --- /dev/null +++ b/441/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2013, + "age_at_initial_diagnosis": 58, + "sex": "male", + "smoking_status": "non-smoker", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 26, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/441/patient_pathological_data.json b/441/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..fa81f5bf53f94be99a9df36d0a37d0bc7209ee7e --- /dev/null +++ b/441/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "441", + "primary_tumor_site": "Hypopharynx", + "pT_stage": "pT4a", + "pN_stage": "pN2b", + "grading": "G3", + "hpv_association_p16": "not_tested", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 34, + "perinodal_invasion": "no", + "lymphovascular_invasion_L": "yes", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "CIS Absent", + "carcinoma_in_situ": "no", + "closest_resection_margin_in_cm": "0.1", + "histologic_type": "SCC_Conventional-Keratinizing", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file diff --git a/441/surgery_description.txt b/441/surgery_description.txt new file mode 100644 index 0000000000000000000000000000000000000000..198741ddf26f3d7512486be0e3d5306dadc1dc68 --- /dev/null +++ b/441/surgery_description.txt @@ -0,0 +1 @@ +Laryngectomy, Partial pharyngectomy, Neck dissection diff --git a/441/surgery_report.txt b/441/surgery_report.txt new file mode 100644 index 0000000000000000000000000000000000000000..fa24744a171f529d260fe63c2141208587b188f7 --- /dev/null +++ b/441/surgery_report.txt @@ -0,0 +1 @@ +First, pharyngoscopy again. The exophytic tumor is seen, which is located in the pharyngeal side wall and in the piriform sinus on the front right and is fixed to the hemilarynx on the right. Confirmed in conjunction with CT above mentioned surgery. Patient was also informed about the use of a radial flap to cover the defect if necessary. First injection of a total of 10 ml Ultracaine 1% with adrenaline into both parts of the neck. Then sterile draping. Create the apron flap subplatysmally in the typical manner. Veins are bipolized and ligated. Dissection of the apron flap up to the level of the hyoid bone or the submandibular gland. Then neck dissection modified radical right: exposure of the digastric muscle, exposure of the omohyoid muscle. Exposure of the cervical vascular sheath. V. jugularis interna, A. carotis interna and externa. Exposure of vagus nerve, accessorius nerve, hypoglossal nerve. The latter must be pushed away from the tumor block, which is successful. Subsequent evacuation level II-V while preserving the branches of the cervical plexus. Neck preparation can be dissected away from the tumor, no per continuitatem growth. The upper pole of the thyroid gland was removed with the tumor specimen, the lower edge parts can be preserved, the thyroid gland was treated with puncture ligation. The superior thyroid artery was cut and ligated. Then modified radical neck dissection on the left: Basic procedure in the same way as on the left side. Exposure of the digastric muscle and omohyoid muscle here too. Exposure of the internal jugular vein, facial vein. Depiction of the common carotid artery, internal carotid artery, external carotid artery. Depiction of vagus nerve, accessorius nerve, hypoglossal nerve. All structures can be well preserved. A. thyroidea superior is dissected long towards the thyroid gland. The thyroid gland is deposited at the isthmus in such a way that a cystic nodule in the isthmus area is deposited together with the tumor specimen, with puncture ligatures on both adjacent sides. Exposure of the trachea. Evacuation of levels II-IV and parts of V. Retention of the branches of the cervical plexus. Subsequent careful hemostasis. Now tumor resection: separation of the infrahyoid muscles from the hyoid bone. Exposure of the upper horn of the thyroid cartilage on the left and dissection of the pharyngeal tube. Release of the piriform sinus. This is not possible on the right due to tumor growth. Thyroid gland is displaced caudo-laterally on both sides with exposure of the trachea from the side. Entry into the larynx on the left paramedian side after exposure of the epiglottis. The exophytic tumor is visible. This is resected on all sides with a safety margin of approx. 1.5-2 cm. Inclusion of the entire pharyngeal musculature. The upper pole of the thyroid gland is integrated into the tumor preparation. Left mucosa-sparing procedure as far as possible. Release of the larynx. Separation of the larynx from the trachea under incision, which extends the trachea cranially. Send in the entire specimen marked with sutures. Also send in 2 marginal samples in the cranial area mucosal marginal sample and cranio-basal. The entire specimen was removed in the healthy area. The cranial mucosal margin sample and the cranio-basal soft tissue margin sample are also healthy, thus R0 status. Overall, there is a defect extending not far from the esophageal entrance; cranially, the defect is connected to parts of the pharyngeal wall. Inspection revealed the possibility of closing the pharynx without a flap, hence the decision to proceed with this procedure. Myotomy first. A tear in the mucosa is seen slightly above the myotomy, which must be sutured. Inconspicuous conditions in the area of the myotomy. This improves the passage. Due to the overall tight mucosal conditions and the mucosal tear near the myotomy, a Provox prosthesis insertion is not performed intraoperatively in this case. The pharyngeal suture is performed. The first layer is performed between the remaining remnants of the pharyngeal wall and the adjacent tongue base tissue. This is done in two layers. The remaining pharyngeal mucosa can now be adapted to create a T-shaped suture. Inverting suture as the first suture. Then 2nd suture on top so that all layers are sutured in two layers. Sutures each with 3-0 Vicryl single button sutures. Third suture cannot be performed as there are no pharyngeal muscle remnants on the right. Hyoid bone was removed cranially to reduce tension. Infrahyoid musculature is sutured to the remains of the suprahyoid musculature using several adaptation sutures. Careful irrigation of the wound area again with H202 and Ringer's solution and careful hemostasis. At the end, the site is free of bleeding. Wound closure in layers and insertion of a Redon drain into both sides of the neck and epithelialization of the tracheostoma. Finally, insertion of a 10 mm tracheostomy tube. The procedure was completed without complications. Patient transferred to intensive care unit for monitoring. Please continue intraoperative antibiotics with Unacid for 2-3 days. Keep the patient fasting for 10 days, then swallow gruel and, if necessary, build up diet. Nutrition in the meantime via the inserted PEG tube. Please leave the feeding tube in place. If the healing process is normal, a Provox prosthesis can then be inserted secondarily. Overall cT4a cN2c hypopharyngeal carcinoma with invasion of the larynx. After laryngectomy and partial pharyngectomy, direct closure in borderline but low-tension conditions. Postoperative presentation of the patient to the interdisciplinary tumor conference. \ No newline at end of file diff --git a/442/InvasionFront_CD3_block7_x3_y3_patient442_0.json b/442/InvasionFront_CD3_block7_x3_y3_patient442_0.json new file mode 100644 index 0000000000000000000000000000000000000000..167efa0aabeb8e3420d2b6facf2ce7ab06db3b6a --- /dev/null +++ b/442/InvasionFront_CD3_block7_x3_y3_patient442_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11512.6, + "Centroid Y µm": 7091.4, + "Num Detections": 25198, + "Num Negative": 16395, + "Num Positive": 8803, + "Positive %": 34.94, + "Num Positive per mm^2": 3205.1 + } +} \ No newline at end of file diff --git a/442/InvasionFront_CD3_block7_x4_y3_patient442_1.json b/442/InvasionFront_CD3_block7_x4_y3_patient442_1.json new file mode 100644 index 0000000000000000000000000000000000000000..ad787a9262819efe1f39655d58ec5ba31428f17d --- /dev/null +++ b/442/InvasionFront_CD3_block7_x4_y3_patient442_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 14201.8, + "Centroid Y µm": 7003.0, + "Num Detections": 24866, + "Num Negative": 15584, + "Num Positive": 9282, + "Positive %": 37.33, + "Num Positive per mm^2": 3402.1 + } +} \ No newline at end of file diff --git a/442/InvasionFront_CD8_block7_x3_y3_patient442_0.json b/442/InvasionFront_CD8_block7_x3_y3_patient442_0.json new file mode 100644 index 0000000000000000000000000000000000000000..a9d465b9a29ec67632fd6c7545ec121858d578f1 --- /dev/null +++ b/442/InvasionFront_CD8_block7_x3_y3_patient442_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13382.5, + "Centroid Y µm": 7896.1, + "Num Detections": 23864, + "Num Negative": 17347, + "Num Positive": 6517, + "Positive %": 27.31, + "Num Positive per mm^2": 2465.4 + } +} \ No newline at end of file diff --git a/442/InvasionFront_CD8_block7_x4_y3_patient442_1.json b/442/InvasionFront_CD8_block7_x4_y3_patient442_1.json new file mode 100644 index 0000000000000000000000000000000000000000..49ae5ed9e3e70b7719b8109df9585555f82d16a9 --- /dev/null +++ b/442/InvasionFront_CD8_block7_x4_y3_patient442_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 15997.7, + "Centroid Y µm": 8056.6, + "Num Detections": 22675, + "Num Negative": 16348, + "Num Positive": 6327, + "Positive %": 27.9, + "Num Positive per mm^2": 2407.2 + } +} \ No newline at end of file diff --git a/442/TumorCenter_CD3_block7_x3_y3_patient442_0.json b/442/TumorCenter_CD3_block7_x3_y3_patient442_0.json new file mode 100644 index 0000000000000000000000000000000000000000..d32efc3c8630a6569642535e711ada62c1365b23 --- /dev/null +++ b/442/TumorCenter_CD3_block7_x3_y3_patient442_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 11244.0, + "Centroid Y µm": 7496.0, + "Num Detections": 24457, + "Num Negative": 15685, + "Num Positive": 8772, + "Positive %": 35.87, + "Num Positive per mm^2": 3224.6 + } +} \ No newline at end of file diff --git a/442/TumorCenter_CD3_block7_x4_y3_patient442_1.json b/442/TumorCenter_CD3_block7_x4_y3_patient442_1.json new file mode 100644 index 0000000000000000000000000000000000000000..d19a52468577ff8876294640e17056173d6bf652 --- /dev/null +++ b/442/TumorCenter_CD3_block7_x4_y3_patient442_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13792.7, + "Centroid Y µm": 7496.0, + "Num Detections": 21546, + "Num Negative": 11411, + "Num Positive": 10135, + "Positive %": 47.04, + "Num Positive per mm^2": 3999.7 + } +} \ No newline at end of file diff --git a/442/TumorCenter_CD8_block7_x3_y3_patient442_0.json b/442/TumorCenter_CD8_block7_x3_y3_patient442_0.json new file mode 100644 index 0000000000000000000000000000000000000000..30a9bc266ff38f9cc23cd8b250ce8e363ea821df --- /dev/null +++ b/442/TumorCenter_CD8_block7_x3_y3_patient442_0.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 10994.2, + "Centroid Y µm": 7670.9, + "Num Detections": 26682, + "Num Negative": 22453, + "Num Positive": 4229, + "Positive %": 15.85, + "Num Positive per mm^2": 1555.8 + } +} \ No newline at end of file diff --git a/442/TumorCenter_CD8_block7_x4_y3_patient442_1.json b/442/TumorCenter_CD8_block7_x4_y3_patient442_1.json new file mode 100644 index 0000000000000000000000000000000000000000..69540ec0aef46cea44e2668f6a378e28a2efd9ab --- /dev/null +++ b/442/TumorCenter_CD8_block7_x4_y3_patient442_1.json @@ -0,0 +1,11 @@ +{ + "patient_tma_measurements": { + "Centroid X µm": 13542.8, + "Centroid Y µm": 7720.9, + "Num Detections": 24498, + "Num Negative": 19458, + "Num Positive": 5040, + "Positive %": 20.57, + "Num Positive per mm^2": 1981.7 + } +} \ No newline at end of file diff --git a/442/icd_codes.txt b/442/icd_codes.txt new file mode 100644 index 0000000000000000000000000000000000000000..c6bd71c16f87da8dd104354070ffb63a2579956b --- /dev/null +++ b/442/icd_codes.txt @@ -0,0 +1 @@ +Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] Halslymphknotenmetastasen[C77.0 B] \ No newline at end of file diff --git a/442/patient_clinical_data.json b/442/patient_clinical_data.json new file mode 100644 index 0000000000000000000000000000000000000000..3534ce26135d3d5ea17dbd2a617c1407104ffbda --- /dev/null +++ b/442/patient_clinical_data.json @@ -0,0 +1,18 @@ +{ + "year_of_initial_diagnosis": 2019, + "age_at_initial_diagnosis": 63, + "sex": "female", + "smoking_status": "former", + "primarily_metastasis": "no", + "survival_status": "living", + "survival_status_with_cause": "living", + "first_treatment_intent": "curative", + "first_treatment_modality": "local surgery", + "days_to_first_treatment": 13, + "adjuvant_treatment_intent": "curative", + "adjuvant_radiotherapy": "yes", + "adjuvant_radiotherapy_modality": "percutaneous radiotherapy", + "adjuvant_systemic_therapy": "yes", + "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin", + "adjuvant_radiochemotherapy": "yes" +} \ No newline at end of file diff --git a/442/patient_pathological_data.json b/442/patient_pathological_data.json new file mode 100644 index 0000000000000000000000000000000000000000..96eafd27f477baefdd7d6ee4c168ede48a0463cd --- /dev/null +++ b/442/patient_pathological_data.json @@ -0,0 +1,20 @@ +{ + "patient_id": "442", + "primary_tumor_site": "Oropharynx", + "pT_stage": "pT3", + "pN_stage": "pN1", + "grading": "hpv_association_p16", + "hpv_association_p16": "positive", + "number_of_positive_lymph_nodes": 2.0, + "number_of_resected_lymph_nodes": 27, + "perinodal_invasion": "yes", + "lymphovascular_invasion_L": "no", + "vascular_invasion_V": "no", + "perineural_invasion_Pn": "no", + "resection_status": "R0", + "resection_status_carcinoma_in_situ": "Ris0", + "carcinoma_in_situ": "yes", + "closest_resection_margin_in_cm": "0.3", + "histologic_type": "SCC_Basaloid", + "infiltration_depth_in_mm": NaN +} \ No newline at end of file