Datasets:

ArXiv:
File size: 7,537 Bytes
b4d7ac8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
import numpy as np
from light_training.dataloading.dataset import get_train_val_test_loader_from_train
# from dataset.brats_data_utils_resample128 import get_loader_brats
import torch 
import torch.nn as nn 
# from ddim_seg.basic_unet import BasicUNet
from monai.networks.nets.unetr import UNETR
from monai.networks.nets.swin_unetr import SwinUNETR
from monai.inferers import SlidingWindowInferer
from light_training.evaluation.metric import dice
from light_training.trainer import Trainer
from monai.utils import set_determinism
from light_training.utils.lr_scheduler import LinearWarmupCosineAnnealingLR
from light_training.utils.files_helper import save_new_model_and_delete_last
from models.uent2d import UNet2D
from models.uent3d import UNet3D
from monai.networks.nets.segresnet import SegResNet
# from ddim_seg.unet3d import DiffusionUNet
# from ddim_seg.ddim import DDIM
# from ddim_seg.nnunet3d_raw import Generic_UNet
# from ddim_seg.basic_unet_denose import BasicUNetDe
# from ddim_seg.basic_unet import BasicUNetEncoder
from models.transbts.TransBTS_downsample8x_skipconnection import TransBTS
import argparse
from monai.losses.dice import DiceLoss
# from light_training.model.bit_diffusion import decimal_to_bits, bits_to_decimal

# from guided_diffusion.gaussian_diffusion import get_named_beta_schedule, ModelMeanType, ModelVarType,LossType
# from guided_diffusion.respace import SpacedDiffusion, space_timesteps
# from guided_diffusion.resample import UniformSampler
set_determinism(123)
import os
from scipy import ndimage


os.environ["CUDA_VISIBLE_DEVICES"] = "6,7"
data_dir = "./data/fullres/train"

logdir = f"./logs_gpu4/diffunet_ep2000"

model_save_path = os.path.join(logdir, "model")
# augmentation = "nomirror"
augmentation = True

env = "pytorch"
max_epoch = 2000
batch_size = 2
val_every = 2
num_gpus = 1
device = "cuda:0"
roi_size = [128, 128, 128]

def get_edge_points(img):
    """
    get edge points of a binary segmentation result
    """
    dim = len(img.shape)
    if (dim == 2):
        strt = ndimage.generate_binary_structure(2, 1)
    else:
        strt = ndimage.generate_binary_structure(3, 1) 
    ero = ndimage.binary_erosion(img, strt)
    edge = np.asarray(img, np.uint8) - np.asarray(ero, np.uint8)
    return edge

def edge_3d(image_3d):
    # image_3d = torch.from_numpy(image_3d)
    b, c, d, h, w = image_3d.shape

    image_3d = image_3d[:, 0] > 0

    return_edge = []

    for i in range(image_3d.shape[0]):
        return_edge.append(get_edge_points(image_3d[i])[None,])
    
    return_edge = np.concatenate(return_edge, axis=0)

    return return_edge

class BraTSTrainer(Trainer):
    def __init__(self, env_type, max_epochs, batch_size, device="cpu", val_every=1, num_gpus=1, logdir="./logs/", master_ip='localhost', master_port=17750, training_script="train.py"):
        super().__init__(env_type, max_epochs, batch_size, device, val_every, num_gpus, logdir, master_ip, master_port, training_script)
        self.window_infer = SlidingWindowInferer(roi_size=roi_size,
                                        sw_batch_size=1,
                                        overlap=0.5)
        self.augmentation = augmentation

        from models.nnunet_denoise_ddp_infer.get_unet3d_denoise_uncer_edge import DiffUNet
        self.model = DiffUNet(1, 10, 3, 1, bta=True)

        self.patch_size = roi_size
        self.best_mean_dice = 0.0
        self.ce = nn.CrossEntropyLoss() 
        self.mse = nn.MSELoss()
        self.train_process = 20
        self.optimizer = torch.optim.SGD(self.model.parameters(), lr=1e-2, weight_decay=3e-5,
                                    momentum=0.99, nesterov=True)
        
        self.scheduler_type = "poly"
        self.bce = nn.BCEWithLogitsLoss()
        self.dice_loss = DiceLoss(sigmoid=True)
        self.cross = nn.CrossEntropyLoss()

    def training_step(self, batch):
        image, label = self.get_input(batch)
        
        pred, pred_edge = self.model(image, label)

        loss_edge = self.cross(pred_edge, label)
        loss_seg = self.cross(pred, label)

        self.log("loss_seg", loss_seg, step=self.global_step)
        self.log("loss_edge", loss_edge, step=self.global_step)

        loss = loss_edge + loss_seg
        return loss
    
    
    def get_input(self, batch):
        image = batch["data"]
        label = batch["seg"]
        # label = self.convert_labels(label)

        # label = label.float()
        label = label[:, 0].long()
        return image, label 

    def cal_metric(self, gt, pred, voxel_spacing=[1.0, 1.0, 1.0]):
        if pred.sum() > 0 and gt.sum() > 0:
            d = dice(pred, gt)
            # hd95 = metric.binary.hd95(pred, gt)
            return np.array([d, 50])
        
        elif gt.sum() == 0 and pred.sum() == 0:
            return np.array([1.0, 50])
        
        else:
            return np.array([0.0, 50])
    
    def validation_step(self, batch):
        image, label = self.get_input(batch)
       
        output = self.model(image, ddim=True)

        # output = output > 0
        output = output.argmax(dim=1)        

        output = output.cpu().numpy()
        target = label.cpu().numpy()
        
        dices = []

        c = 10
        for i in range(1, c):
            pred_c = output == i
            target_c = target == i

            cal_dice, _ = self.cal_metric(target_c, pred_c)
            dices.append(cal_dice)
        
        return dices
    
    def validation_end(self, val_outputs):
        dices = val_outputs

        dices_mean = []
        c = 9
        for i in range(0, c):
            dices_mean.append(dices[i].mean())

        mean_dice = sum(dices_mean) / len(dices_mean)
        
        self.log("0", dices_mean[0], step=self.epoch)
        self.log("1", dices_mean[1], step=self.epoch)
        self.log("2", dices_mean[2], step=self.epoch)
        self.log("3", dices_mean[3], step=self.epoch)
        self.log("4", dices_mean[4], step=self.epoch)
        self.log("5", dices_mean[5], step=self.epoch)
        self.log("6", dices_mean[6], step=self.epoch)
        self.log("7", dices_mean[7], step=self.epoch)
        self.log("8", dices_mean[8], step=self.epoch)

        self.log("mean_dice", mean_dice, step=self.epoch)

        if mean_dice > self.best_mean_dice:
            self.best_mean_dice = mean_dice
            save_new_model_and_delete_last(self.model, 
                                            os.path.join(model_save_path, 
                                            f"best_model_{mean_dice:.4f}.pt"), 
                                            delete_symbol="best_model")

        save_new_model_and_delete_last(self.model, 
                                        os.path.join(model_save_path, 
                                        f"final_model_{mean_dice:.4f}.pt"), 
                                        delete_symbol="final_model")


        print(f"mean_dice is {mean_dice}")

if __name__ == "__main__":

    trainer = BraTSTrainer(env_type=env,
                            max_epochs=max_epoch,
                            batch_size=batch_size,
                            device=device,
                            logdir=logdir,
                            val_every=val_every,
                            num_gpus=num_gpus,
                            master_port=17759,
                            training_script=__file__)

    train_ds, val_ds, test_ds = get_train_val_test_loader_from_train(data_dir)

    trainer.train(train_dataset=train_ds, val_dataset=val_ds)