""" Data loading for grn_dense4. Uses SparseRawDeltaCache to get dense (B, G_sub, G_sub) delta attention, then computes per-row statistics [mean, std, max, min] → (B, G_sub, 4) in the DataLoader worker to minimize CPU→GPU transfer. """ import sys import os import torch from torch.utils.data import Dataset _SCDFM_ROOT = os.path.normpath( os.path.join(os.path.dirname(__file__), "..", "..", "..", "..", "transfer", "code", "scDFM") ) _cached_classes = {} def get_data_classes(): """Lazily import scDFM data classes with proper module isolation.""" if _cached_classes: return ( _cached_classes["Data"], _cached_classes["PerturbationDataset"], _cached_classes["TrainSampler"], _cached_classes["TestDataset"], ) saved = {} for key in list(sys.modules.keys()): if key == "src" or key.startswith("src."): saved[key] = sys.modules.pop(key) for d in ["src", "src/data_process", "src/utils", "src/tokenizer"]: init_path = os.path.join(_SCDFM_ROOT, d, "__init__.py") if not os.path.exists(init_path): os.makedirs(os.path.dirname(init_path), exist_ok=True) with open(init_path, "w") as f: f.write("# Auto-created by CCFM\n") sys.path.insert(0, _SCDFM_ROOT) try: from src.data_process.data import Data, PerturbationDataset, TrainSampler, TestDataset _cached_classes["Data"] = Data _cached_classes["PerturbationDataset"] = PerturbationDataset _cached_classes["TrainSampler"] = TrainSampler _cached_classes["TestDataset"] = TestDataset finally: for key in list(sys.modules.keys()): if (key == "src" or key.startswith("src.")) and not key.startswith("scdfm_"): del sys.modules[key] for key, mod in saved.items(): sys.modules[key] = mod if _SCDFM_ROOT in sys.path: sys.path.remove(_SCDFM_ROOT) return Data, PerturbationDataset, TrainSampler, TestDataset class GRNDatasetWrapper(Dataset): """ Wraps scDFM PerturbationDataset to produce per-row statistics from dense delta. Worker computes: dense delta (B, G_sub, G_sub) → [mean, std, max, min] → (B, G_sub, 4) Only the 4-dim stats are sent to GPU, not the full G_sub×G_sub matrix. """ def __init__(self, base_dataset, sparse_cache, gene_ids_cpu, infer_top_gene): self.base = base_dataset self.sparse_cache = sparse_cache self.gene_ids = gene_ids_cpu self.infer_top_gene = infer_top_gene def __len__(self): return len(self.base) def __getitem__(self, idx): batch = self.base[idx] # 1. Random gene subset G_full = batch["src_cell_data"].shape[-1] input_gene_ids = torch.randperm(G_full)[:self.infer_top_gene] # 2. Dense delta from sparse cache (in worker process) src_names = batch["src_cell_id"] tgt_names = batch["tgt_cell_id"] if src_names and isinstance(src_names[0], (tuple, list)): src_names = [n[0] for n in src_names] tgt_names = [n[0] for n in tgt_names] z_dense = self.sparse_cache.lookup_delta( src_names, tgt_names, input_gene_ids, device=torch.device("cpu") ) # (B, G_sub, G_sub) # 3. Per-row statistics: (B, G_sub, G_sub) → (B, G_sub, 4) z_stats = torch.stack([ z_dense.mean(dim=-1), # mean of each gene's attention changes z_dense.std(dim=-1), # spread of attention changes z_dense.max(dim=-1).values, # strongest positive change z_dense.min(dim=-1).values, # strongest negative change ], dim=-1) # (B, G_sub, 4) # 4. Subset expression data return { "src_cell_data": batch["src_cell_data"][:, input_gene_ids], "tgt_cell_data": batch["tgt_cell_data"][:, input_gene_ids], "condition_id": batch["condition_id"], "z_stats": z_stats, # (B, G_sub, 4) "gene_ids_sub": self.gene_ids[input_gene_ids], "input_gene_ids": input_gene_ids, }