The role of adult service websites in addressing modern slavery Professor Teela Sanders and Dr Rachel Keighley School of Criminology, University of Leicester Executive Summary: • The landscape where modern slavery and sexual exploitation takes place has changed with the onset of digital technologies dominating the organisation of the commercial sex industry. • Adult Service Websites (ASWs), where most sexual services are advertised, negotiated and facilitated in the UK, are a space where exploiters can manipulate, entrap, coerce, and force individuals into selling sexual services. • The role of ASWs in facilitating offending behaviour is complicated and unregulated as national intelligence services try to understand routes to trafficking, the police work to identify victims and target offenders, and first responders deliver interventions to victims of sexual exploitation. • Researchers from the University of Leicester, in partnership with the National Crime Agency, National Police Chief's Council, and the Unseen investigated what role ASWs can play in preventing human trafficking and sexual exploitation in the UK, and their role in wider policies and laws on this issue. Methods: A mixed methods approach formed the framework of the research design. We chose this approach so the project could generate a unique body of evidence that reaches beyond existing data or government consultation: • An online questionnaire for providers and consumers using ASWs (n=142) • In-depth interviews with ASW staff (n=5) • Interviews with police (n=30 across 23 forces in England and Wales) and practitioners (n=13) involved with ASWs engagement and enforcement • Analysis of contemporary historical records and data from the last five years from the Unseen Helpline to identify knowledge on the role of ASWs in reported cases of modern slavery. Survivor involvement: Embedded into the project was ethical survivor involvement in peer research. Working alongside Unseen, the peers were involved through participation in the advisory group, instrument design, implementation, analysis, and the dissemination phase. We provided capacity building through a bespoke training package of Action Learning Sets. The regulation of ASWs: The interviews explored the current regulatory practices of ASWs and their responsibilities in preventing MSHT and how this could be improved with forthcoming UK legislation (UK Online Safety Bill): • Pop-up and easy to use reporting mechanisms. • Dedicated support pages and customer care/community teams. • ASW working groups with the NCA and police and partnerships with NGOs and sex worker support groups and operationalising feedback. • Human and AI moderation of content. • Multi-layered verification measures. • Proactive removal of illegal content to protect those selling sex. • Proactive reporting cases to the police and data sharing/complete compliance with investigations. ‘We are aware that ASWs remain a significant enabler within the sexual exploitation, modern slavery, and human trafficking threat, and we strongly believe that any business operating in this space has a responsibility to understand the risks involved, and to mitigate those risks to the best of its abilities.’ (ASW Operator) 4% 6% 2% 2% 3% 83% Coercion (Threats, blackmail, etc.) False promises or statements Familial Intimate partner/marriage proposition Job offer/advertisement Unknown Figure: The Recruitment Tactics used by potential exploiters to abuse and exploit individuals for sex on ASWs ‘I think if they’re going to exist, they have a responsibility in prevention. I won't make a comment on whether or not they exist, they exist, so I think therefore they have a responsibility in prevention. It probably fundamentally doesn’t work well for their business model to be a huge advocate for prevention. I think that’s the difficulty.’ (Intelligence Officer and Head of Operations, National Charity) https://doi.org/10.25392/leicester.data.23629005


OpenSourcePrinciplesUtilizedbytheCERESEdition5Level-3Framework Thomas.N.Hillyer@nasa.gov, ADNET Joshua.C.Wilkins@nasa.gov, ADNET 0. Abstract The Clouds and the Earth’s Radiant Energy System (CERES) Science Team integrates and fuses observations from six CERES instruments aboard the Terra, Aqua, S-NPP, and NOAA-20 missions with data from twenty-five geostationary imagers, in creating a nearly 25-year, ongoing record of the Earth’s radiation budget. In preparation for the next version of CERES data products, the team has been exploring software development methods leveraging open-source principles and software to streamline data product configuration and algorithm implementation. This effort will provide robust software for production while maintaining greater flexibility for the algorithm developers to explore new science. Developers on the CERES Level 3 products have created a framework allowing greater modularization and flexibility to design and configure CERES Level 3 products while reducing development time. The framework leverages open data formats to configure data variables and attributes within the product, declare tolerances for input validation, select resolution and binning schemes, and allow algorithm selection at runtime without requiring recompilation of the product generator. The framework incorporates means to perform unit and integration testing allowing more rapid feedback to the science team. The framework has been used for one current CERES data product and has demonstrated promise for upcoming products in development. 1. Requirements The CERES Level 3 working group lead’s goals for Edition 5 framework are the following improvements over Edition 4: • Modular and Flexible – Single Purpose Algorithms and Functions – Minimal Disruption When Swapping Algorithms • Configurable – Minimize Need for Constant Source Code Changes – Favor Descriptive and Structured Configuration Files Where Possible – Enable/Disable Scientific Parameters as Needed – Easily Change Processing Modes ∗Binning - how footprints are assembled ∗Gridding · 1◦, 1/2◦, etc. · equal angle or equal area gridding • Rapid Development and Analysis – Adjustable Granularity ∗Daily ∗Monthly – Quick Tests or Long-Term Analysis 2. Programming Languages Part of the updated Edition 5 framework in- volves extensive refactoring of the existing Edition 4 Fortran 90 codebase to take greater advantage of object oriented facilities in modern languages. • C++-17 TISA Gridding • Fortran 2018 TISA Averaging 3. Improved Unit Testing Increased modularization allows easier incorporation of unit testing for Level 3 software. CERES Edition 5 framework is using the open source doctest frame- work allowing tests to be written into production code. https://github.com/doctest/doctest 4. JSON-based Product Configuration JSON-based configuration files are used to define the struc- ture of data products, valid ranges for input and output prod- ucts, and various attributes to be included with the final prod- uct. Many libraries exist allowing JSON-based configuration parameters to be shared across both product generators and programming languages. 5. JSON Properties Used in Code The framework makes use of the following open source C++ JSON library hosted on Github: https://github.com/nlohmann/json 6. Proof of Concept (CRS1deg-Hour) The CERES Edition 4 CRS1deg-Hour data product was se- lected to be a proof of concept for exercising the Edition 5 Level 3 framework. The CRS1deg-Hour product provides hourly CERES Clouds and Radiative Swath (CRS) longwave and shortwave computed vertical flux profiles and cloud prop- erties spatially gridded into 1◦-regions. The CRS1deg-Hour PGE was recently delivered to produc- tion and uses the Edition 5 framework (using Edition 4 CRS data) and creates a user-friendly, gridded NetCDF-4 data product. Using the framework, it was easy for the team to use the JSON configuration files to define key features and settings to use at runtime, declare toleranc


DE German Reproducibility Network The German Reproducibility Network (GRN) What is it and why is it worth joining? What is the GRN? • Peer-led cross-disciplinary consortium, which aims to foster reproducibility, trustworthiness and openess of scientific research on a national level • Activities: – Promotion of training and education on open science practices – Bringing stakeholders together – Various exchange formats (e.g. virtual brainstorming events, workshops) • Founded on February 1, 2021 • 42 members (as of July 2023) – 33 local reproducibility initiatives – 5 research institutions – 2 academic societies Why is it worth joining? • Signal institutional commitment to open science and reproducible research • Initiate strategic discussion on open science and reproducibility of research at the institution. • Collaborate with local reproducibility initiatives • Support researchers from your own institution with materials from network partners • Take advantage of a wide range of exchange and networking opportunities How can we join the GRN? • Check conditions for membership • How to join – For reproducibility initiatives: Informal application – For research institutions: Development of a research improvement strategy & create a senior academic role with responsibility for promoting quality, robustness and transparency of research + Memorandum of Understanding – For academic societies: Memorandum of Understanding • More information: https://reproducibilitynetwork.de/join Keep in touch https://reproducibilitynetwork.de @GermanRepro@mastodon.world @GermanRepro info@reproducibilitynetwork.de Subscribe to our mailing list: grn@lists.lrz.de Antonia C. Schrader, Helmholtz Open Science Office https://orcid.org/0000-0001-7080-634X David Philip Morgan, University of Mannheim https://orcid.org/0000-0001-8213-451X Philipp Zumstein, University of Mannheim https://orcid.org/0000-0002-6485-9434 This work, excluding logos, is licensed under a Creative Commons Attribution 4.0 International. https://creativecommons.org/licenses/by/4.0/deed.de Bremen Lübeck Rostock Potsdam Münster Bochum Göttingen Leipzig Dresden Bayreuth Mannheim Tübingen Munich Landau in der Pfalz Frankfurt am Main Jena Bonn Berlin Kiel Würzburg


INTRODUCTION Over decades, smoking has been identified as one of the most preventable public health problems. However, rate of reduction in smoking prevalence has been relatively stagnant over the past decade. In parallel to the WHO Framework Convention on Tobacco Control (WHO FCTC) initiatives, quit smoking clinics (QSCs) have been established in various health clinics across Malaysia to proactively promote and aid smoking cessation amongst patients especially those with other comorbidities. The use of certain pharmacotherapy has been impeded by the cost in view of the higher pricing even though it may be more effective in aiding one to kick smoking habits. As such, it is pivotal for research to be conducted to evaluate both the efficacy and the cost of the interventions to determine the more cost-effective treatment regime. A retrospective study was conducted in Kuala Lumpur Health Clinic (KKKL) where medical records of patients who attended the QSC from January 2018 to December 2018 were evaluated. Cost estimation was done via macro and micro costing. The primary aim of this study was to evaluate the cost-effectiveness of combination therapy against monotherapy in smoking cessation program, hence providing evidence of the most effective intervention in the local setting. To predict the relationship between monotherapy and combination therapy on successful quitting, the treatment regimens were regressed on the outcome variables with a statistical significance set at a level of p<0.05. A total of 213 health records were evaluated and 94.8% were mainly male and 73.7% Malays. Majority of the samples (124 participants) were provided with combined therapy (nicotine and varenicline) and 89 participants were given monotherapy (nicotine only). It was found that none of the sociodemographic variables affects the outcome of quitting except for those with higher education level having significantly higher odds of quitting compared to those in the lower education level. Overall combination therapy was more effective in aiding smoking cessation (74.2% successful rate) compared to monotherapy (34.8% successful rate). Cost of treatment per patient for combination therapy was RM1,028.25, whereas for monotherapy was RM819.13. Cost- effectiveness ratio revealed that combination therapy is more cost-effective compared to monotherapy which cost per one percent successful rate was RM1,718 and RM2,095 respectively. In conclusion, combination therapy is more cost-effective compared to monotherapy in smoking cessation program conducted in Kuala Lumpur Health Clinic. Therefore, combination therapy should be the preferred choice for smoker to quit smoking compared to monotherapy. METHODOLOGY The study population consisted of 213 patients who had attended the smoking cessation clinic at KKKL in 2018. The general characteristics of the study population were mainly male dominated (94.8%) and Malays (73.7%). This was consistent with the current demographics of smokers in Malaysia. The mean ages of the smokers were similar in both the monotherapy and combination therapy arms, mainly aged above 40 years old. Treatment Outcome Analysis Treatment outcome was assessed by the number of successful smoking cessation as defined by smoke free for at least six months Treatment modalities and treatment outcome (N=213) Successful Not Successful Monotherapy 31 58 Combination Therapy 92 32 Total 123 90 Out of the 213 registered patients on pharmacotherapy, approximately two third of the patients have at least one comorbidity. Over one-third of them had either hypertension or diabetes with merely 3% of them have tuberculosis. Nevertheless, descriptive characteristics of the study population that was reported cessation outcome showed that none of the baseline characteristics have a clear-cut implication on success rate of smoking cessation. From the dataset, presence of different types of comorbidities did not statistically change the proportion of quit rate. Further ana


In the Wild Fast!! Real-time plotting + interactivity Pure python: Native Python data structures & NumPy arrays, no C++ required Extensive: Supports images, scatterplots, lines, 3D graphs, meshes, colormaps, parameter configs, custom graphics, and more Integratable: Seamlessly fits into any PyQt/PySide application Summary Legend • Non-linear transformations • Multiple vertical and horizontal scales/axes on the same plot • More CuPy & Numba integration • Support being a plot backend for Pandas Future Work PyQtGraph - High Performance Visualization for All Platforms Ognyan Moore, Nathan Jessurun, Martin Chase, Nils Nemitz, Luke Campagnola SciPy 2023 A – Antenna Array Analysis – https://github.com/rookiepeng/antenna-array-analysis B – argos – https://github.com/titusjan/argos C – ndscope – https://git.ligo.org/cds/software/ndscope D – iris – https://github.com/LaurentRDC/iris-ued E – barney – https://github.com/j9ac9k/barney F – SO2 – Alaska Volcano Observatory G – S3A – https://gitlab.com/s3a/s3a H – neurotic – https://neurotic.readthedocs.io I – xrayrecon – https://gitlab.com/ficsresearch/xrayrecon J – EnMAP-Box – https://enmap-box.readthedocs.io K – joulescope – www.joulescope.com/ L – ephyviewer – https://ephyviewer.readthedocs.io See more at https://github.com/pyqtgraph/pyqtgraph#used-by PyQtGraph is a plotting library that integrates NumPy and the Qt framework, allowing users to develop scientific applications where high performance, interactivity, and cross-platform compatibility are a given. It is:


Applicability of breast cancer 313 Polygenic Risk Score (PRS313) in the Spanish region of Navarra Edurne Urrutia-Lafuente1, Ane Miren Sagardia Fernández1, Maria Miranda Pérez1, David Cobos Hermosa1, Óscar Teijido1, David Gómez-Cabrero1#, Ángel Alonso1,2#. 1. Navarrabiomed - IdiSNA - HUN, Genomic Medicine Unit, Pamplona, Spain. 2. Hospital Universitario De Navarra, Genetics Department, Pamplona, Spain. AIM METHODS 2. Individual assessment: · Exploratory analysis · Differential expression · Functional enrichment 1. Systematic review of public repositories and selection of transcriptomic studies: RNA-seq and microarrays. 3. Meta-analysis and functional enrichment 3.1. Synthesis of the functional enrichment The aim of this study was to identify and understand the molecular mechanisms underlying sex-based differences in RA. SCREENING INCLUDED SEARCH #1: GEO 172 records 200 records after removing duplicates 41 full-text articles assessed for eligibility 6 STUDIES INCLUDED in the individual assessment 5 STUDIES INCLUDED in the meta-analysis Figure 1. PRISMA diagram that represents the workflow of the systematic review. Meta-analysis and functional enrichment 10 genes, 90 biological processes and 11 KEGG pathways were identified as significantly sex- dependent. The enrichment results suggest a higher immune system activity and a larger presence of energy precursors in female RA patients, among others. Male RA patients, in contrast, showed an overrepresentation of terms related to protein biosynthesis and negative regulation of osteoblasts (Figures 2, 3). Data analysis workflow Comparison GOslim terms Figure 2. Pyramid of GOslim terms. The horizontal axis shows the number of GO terms associated to each GOslim term. Terms overrepresented in males are displayed in red, and those overrepresented in females, in blue. RA - CONTROL VS RA - CONTROL SEARCH #2: ArrayExpress 78 records Polygenic risk scores (PRS) have demonstrated their potential to predict the probability of developing cancer. This allows risk stratification and thus improved screening programmes. Among them, PRS313 is the best-performing breast cancer PRS for European-ancestry women.1 The NAGENMx project aims to provide the necessary evidence to implement a personalized breast cancer-screening program in Navarra based on this PRS. Therefore, prior validation in our population is essential to ensure an accurate stratification. The goal of this study was to evaluate the applicability of breast cancer PRS313 in the Spanish region of Navarre. METHODS REFERENCES 1. Mavaddat, et al. (2019). Polygenic risk scores for prediction of breast cancer and breast cancer subtypes. The American Journal of Human Genetics, 104(1), 21-34. 2. Collister, J. A., Liu, X., & Clifton, L. (2022). Calculating polygenic risk scores (PRS) in UK Biobank: a practical guide for epidemiologists. Frontiers in Genetics, 13, 105. 3. Choi, S. W., Mak, T. S. H., & O’Reilly, P. F. (2020). Tutorial: a guide to performing polygenic risk score analyses. Nature protocols, 15(9), 2759-2772. CONCLUSIONS Samples Data analysis workflow 1. Sample selection: 2. Exploratory data analysis (EDA): High risk (Hereditary breast cancer criteria) 3. PRS evaluation2,3 INTRODUCTION RESULTS RESULTS • Missing SNPs pose a major limitation when applying existing PRSs to new populations. • The greater separation between the control and moderate-risk groups might suggest a higher polygenic burden in the latter, while the high-risk group with strong family history could be explained by rare mutations not included in the PRS313. However, further exploration is still needed. • Ultimately, applying existing PRSs in different populations is challenging and requires standard guidelines for their evaluation and for dealing with missing data. AIM Moderate risk (Family history) Population risk 3.2. Model selection 1. How many samples were included in the study? 3. 1 How did we address these missing SNPs? 3.1 Missing SNPs Women Navarre Figure 3. Dens


U.S. Environmental Protection Agency Office of Research and Development Applying EcoToxChips to identify Potential Gene Expression Markers of Exposure to Glucocorticoid Receptor Agonists 1 ORISE Fellow, US EPA, Office of Research and Development, Great Lakes Toxicology and Ecology Division, Duluth, MN 2 US EPA, Great Lakes Toxicology and Ecology Division, Duluth, MN Introduction Principal Component Plot Conclusion Identification of Novel Transcriptomic Markers References • Among 375 genes evaluated, six genes were differentially expressed across more than one treatment and identified as biomarker candidates for GR-agonism. • The up-regulated genes were acsl5, scd, odc1, and gadd45ga. • The down-regulated genes were slc27a6 and dgat2. • These genes were all found to be sensitive at an environmentally relevant concentration of dexamethasone (40ng/L) and responded in the same direction across all treatments of dexamethasone and BDP. Furthermore, the magnitude of induction and/or down-regulation following dexamethasone was dose-dependent. • Results of this study provide additional candidate genes to consider as potential markers of in vivo exposure to GR-agonists in field studies employing caged fish. Jacob Collins1, Jenna Cavallin2, Alex Cole1, Kathleen Jensen2, Michael Kahl2, Kelvin Santana Rodriguez1, Ashley Kittelson1, Dan Villeneuve2 Glucocorticoid-mediated bioactivity has been detected in North American surface waters1. However, the bioavailability and in vivo potency of glucocorticoid receptor (GR) agonists in environmental mixtures remains undefined. • Dexamethasone (DEX) and Beclomethasone dipropionate (BDP) were used as positive controls related to glucocorticoid receptor (GR) agonism, • 40ng/L DEX was used an environmentally relevant concentration. • 18 µg/L of BDP was used as a positive control for glucocorticoid receptor agonism. • Initial selection of gene expression endpoints were based on mammalian genes known to be regulated by GR signaling: sgk1, nr3c1, nfkbiaa. Potential transcriptomic markers of GR activation were identified by the direction and magnitude of their Log2 fold change (FC). Targets that were determined to be viable were those that demonstrated a dose-dependent response. Preliminary Results 96 Hour Adult Fathead Minnow Study Test Conditions • 5-6 month old male fathead minnows (FHM) were distributed amongst 15 tanks with 3 replicate tanks per treatment. • Filtered and UV-treated Lake Superior Water (LSW) was utilized as control water. • A continuous flow through system of approximately 45mL/min was utilized. • The photoperiod was 16:8; light:dark. • Water temperature was kept at 25.3 ± 0.3°C. • FHM were fed bring shrimp twice daily. • Water conditions (temperature, pH, dissolved oxygen, conductivity, flow-rate, and survival) were monitored over the course of the test. Treatment Groups • LSW Control • Dex 40ng/L (0.1 nM) • Dex 0.40mg/L (1uM) • Dex 4.0mg/L (10uM) • BDP 17.8ug/L (34.2 nM) 1. Cavallin JE, Battaglin WA, Beihoffer J, Blackwell BR, Bradley PM, Cole AR, Ekman DR, Hofer RN, Kinsey J, Keteles K, Weissinger R, Winkelman DL, Villeneuve DL. Effects-Based Monitoring of Bioactive Chemicals Discharged to the Colorado River before and after a Municipal Wastewater Treatment Plant Replacement. Environ Sci Technol. 2021 Jan 19;55(2):974-984. doi: 10.1021/acs.est.0c05269. Epub 2020 Dec 29. PMID: 33373525; PMCID: PMC8135223. 2. Basu N, Crump D, Head J, Hickey G, Hogan N, Maguire S, Xia J, Hecker M. EcoToxChip: A next-generation toxicogenomics tool for chemical prioritization and environmental management. Environ Toxicol Chem. 2019 Feb;38(2):279-288. doi: 10.1002/etc.4309. PMID: 30693572. EcoToxChip Assay Procedure • RNA samples were converted to cDNA and combined with nuclease-free water and PCR master mix before distribution across a 96 well qPCR plate. • Samples from the 96 well plate were then transferred to a 384 well EcotoxxChip plate utilizing the Beckmen Coulter Biomek i5 • PCR analysis was perfor


INTRODUCCIÓN 6 de noviembre de 2021-actualidad: La paciente mejora progresivamente, persistiendo algunos meses ciertos olvidos puntuales y conductas infantiles, hasta la práctica desaparición de sintomatología psicótica o disociativa con recuperación completa de funcionalidad personal y en sociedad. Su tratamiento de mantenimiento es: Lamotrigina 100mg. 1-0-1/2, Litio 400mg. 1/4-0-1/2, Olanzapina 2.5mg. si ansiedad o insomnio, Escitalopram 20mg. 1-0-0 A PROPÓSITO DE UN CASO INCIERTO Fombellida Velasco, C. (Licenciada Especialista en Psiquiatría); Domínguez Álvarez, E. (Licenciada Especialista en Psiquiatría); Sánchez Chillón, A. (MIR de Psiquiatría); Beltrán Mercado, C.E. (MIR de Psiquiatría) REUNIÓN 2024 EN PALENCIA DE LA 24 de mayo de 2021, Urgencias Acude por insomnio de una semana. Vacunado para SARS-COV2 recientemente. • Exp. psicop.: ansiedad ideica, discurso adecuado pero monosilábico, no clínica psicótica, insomnio. • Diagnóstico: insomnio • Plan y tratamiento: alta a domicilio con Escitalopram 10mg 1-0-0 (preeescrito por ORL privada), Trazodona 100mg. 0-0-1/2. Control por M.A.P. 11-28 de junio de 2021, Urgencias e ingreso en agudos: Dos días tras su alta, regresa a Urgencias con mutismo, ideación de culpta y ruina y tapándose la boca resistiendo la reinstauración de antipsicótico (Risperidona). • Sedimentos de orina: infección de orina Se decide ingreso: hipotimia y sensación de “ser una carga para su hijo”. Presenta picos hipertensivos alternando con hipotensión y fiebre junto a desorganización mental y conductual compatible con sdr. confusional. Buena evolución y posterior traslado a Unidad de Convalecencia. • Diagnóstico: síndrome ansioso-depresivo y disautonómico/ confusional en contexto de ITU 25 de mayo-8 de junio de 2021, ingreso en agudos: Durante su estancia en planta, la paciente está mutista y escasamente reactiva, no es posible toma de medicamento precisando adiministración i.m. mostrando mejoría significativa al día siguiente. Posteriormente gracias a tto. con Venlafaxina, Clonazepam y Risperidona mejoría gradual de sintomatología disociativa, percepciones y quejas somáticas y posibles síntomas psicóticos. Durante su estancia refirió “estar más preocupada por la pandemia, “esta no es mi voz” y “huelo mal”, “mi piel se está pudriendo” y “mi familia ha venido aquí porque estoy muerta y este es mi funeral”. • Diagnóstico: trastorno disociativo • Plan y tto.: alta con Venlafaxina 5mg. 1-0-0, Clonazepam 0.5mg. Octubre de 1987, ingreso en agudos • Ingreso breve por mutismo y obnubilación que cede con Haloperidol, Tioridazina y Flunitrazepam. • Diagnóstico: trastorno disociativo vs. psicótico (menos probable) Septiembre de 1988, ingreso en agudos: • Episodio maniaco con síntomas psicóticos y desorganización conductual severa con agitación. • Tratamiento: Haloperidol, Flunitrazepam y Valpromida, Litio • Diagnóstico: episodio maniaco con síntomas psicóticos en trastorno bipolar tipo I 25 de mayo de 2021, Urgencias Regresa acompañada de su hijo refiriendo que habla menos, casi mutismo y persiste insomnio. Sin quejas somáticas. La nota más rara desde que toma el Escitalopram por lo que lo retira. Desde hace diez días está preocupada por un posible cáncer al notar prurito laríngeo, que ha consultado con ORL privada diagnosticando reflujo gastroesofágico. • Exp. psicop.: poco colaboradora, ligera resistencia física a entrar en consulta que cede, ansiedad ideica moderada, cierta inquietud psicomotriz, mutista, insomnio. • Interconsulta a Neurología: no patología neurológica urgente • Diagnóstico: trastorno depresivo vs. disociativo a estudio • Plan: ingreso en Unidad de Hospitalización de Agudos. 28 de junio-22 de octubre de 2021, ingreso en Convalecencia Al principio miedo a comer/tragar, mostrándose insegura y no relacionándose, con clínica depresiva y episodios compatibles con cuadros disociativos que ceden con benzodiacepinas y neurolépticos sedantes. Persiste miedo a enfrentarse al exterior. Ante falta de remisión


Barriers of Mental Health in Undocumented Latinos Ashley Perez, University of Illinois at Chicago Dr. Joseph Hoereth, Institute for Policy & Civic Engagement, University of Illinois at Chicago Research Objective As the rates of mental health illness continue to grow in the United States, this study aims to review what is being said when it comes to mental illness and undocumented Latino immigrants. Taking the opportunity to peer into what is being said in the subpopulations within the undocumented Latino immigrants: women, men, and youth. The question that is being explored is: What are the barriers to accessing mental health services for undocumented Latino immigrants in the United States? The purpose of this study is to encourage researchers to ensure they are acutely aware of the subpopulations of undocumented Latinos that need to be included in studies that focus on mental health and to encourage policymakers to include undocumented Latino immigrants in public policy to increase access to mental health services. Methodology (Literature review: 1985 to 2022) Journals: J. of Consulting & Clinical Psychology, Hispanic Health Care Intern., Intern. J. Of Geriatric Psychiatry, American Psychiatric Association, American Psychiatric Nurses Association, Advances In Nursing Science, Medical Care, Psychiatric Services, Social Science & Medicine, Hein Law J., American Association of Nurse Practitioners, Social Science & Medicine, Health Politics Policy Law, J Immigrant Minority Health. Latinos in General Undocumented Latinos in General Undocumented Latina Women & Depression Undocumented Latino Men & Emotionality • Depression in Latina women is more prevalent with only 13.8% of Latinas receiving any type of mental health support in 2008 (Shatell, 2008). • In 2016, 10% of undocumented Latina immi- grants received mental health care when 45% met the criteria for depression (Derr, 2016). • Latina women are more likely to have higher rates of post-partum depression with 60% of undocumented Latina immigrants showing sig- nificant PPD that could lead to suicidal think- ing, according to a study conducted in 2013 (Shellman, 2013). • Latino men have higher rates of successful suicide than Latina women, four times the rate in 2018 (CDC, 2021). • Undocumented Latino men are more likely to experience restrictive emotionality and depression due to the cultural values of being the breadwinners of their families. • The stress to support their families in addition to other stressors such as experiencing racism, expectations based on their gender, physical strains due to work could ultimately lead to men feeling overwhelmed, burnout, and experiencing symptoms of depression. Undocumented Latino Youth & Immigration Trauma Policy Recommendations Findings • Undocumented Latino youth who experiences traumatic events in their home countries had higher levels of depression, anxiety, post-traumatic stress disorder due to the journey of immigration and acculturation. • Where two-third of youth out of a 104-youth study (69.3%) that was surveyed had experienced at least one traumatic event that deeply influenced the mental health of the youth (Cleary, 2018). • As of 2022, there are no healthcare policies within federal or state levels that include undocumented immigrants within their framework. • “Undocumented immigrants are explicitly excluded from the Patient Protection and Affordable Care Act’s (ACA) health insurance exchanges, cost-sharing reductions, health insurance mandate, tax credits, and the expansion of Medicaid’s traditional provisions.” (Ortega, 2018). • Undocumented Youth who are DACA (Deferred Action for Childhood Arrivals ) recipients reported “Majority reported not being offered coverage. As they are disqualified for coverage through the Affordable Care Act (ACA)” (Siemons, 2017). • Improvements and revisions to the policies around government healthcare programs such as Medicaid, Medicare & Affordable Care Act to be inclusive of the entire popul


SFB 1391 Andere Ästhetik Gastvortrag Dr. Grace Stafford (Universität Wien) Women’s Patronage and Visual Culture in Late Antiquity: From Honorific Statuary to Donor Portraits Mittwoch, 29. Mai 2024, 18 Uhr c.t. Ernst von Sieglin Hörsaal (Raum 165), Schloss Hohentübingen, Burgsteige 11, 72070 Tübingen Alle Interessierten sind herzlich willkommen! Der Vortrag findet statt im Rahmen des Teilprojekts A1: Ästhetik der Ämter: Repräsentation spätrömischer Reichsbeamter (4.–6. Jh.) Prof. Dr. Cristina Murer, Prof. Dr. Sebastian Schmidt-Hofner, PD Dr. Martin Kovacs


Material Normalised RMS (mV/g-1s) Lactose 200M 121 ± 15% Avicel PH102 30 ± 3% Avicel PH101 23 ± 8% Maize Starch 12 ± 7% Lactose #316 Fast Flo 4 ± 7% Feasibility study on the in-line measurement of pharmaceutical powder mass flow rate and charging characteristics using an electrostatic powder flow sensor (EPFS). Hill-Izani, N.Y., Smith, G., Armitage. D.A., Polygalov, E. Pharmaceutical Technologies, School of Pharmacy, De Montfort University, Leicester LE1 9BH Results 16.548 33 21.998 62 26.308 28 30.601 90 R² = 0.88 0 5 10 15 20 25 30 35 40 0 1 2 3 4 5 6 7 8 9 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 160 rpm 140 rpm 380.82 116 521.37 139 572.27024 673.21 304 R² = 0.96 0 200 400 600 800 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm 38.974 25 51.094 51 60.149 30 65.85456 R² = 0.92 0 20 40 60 80 100 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm 60.377 08 55.837 13 60.326 07 63.922 40 R² = -7.16 0 20 40 60 80 100 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm 74.520 38 81.850 41 75.881 74 76.844 03 R² = -15.13 0 50 100 150 200 0 1 2 3 4 5 6 7 Mean RMS (mV) Mean mass flow rate (g/s) 100 rpm 120 rpm 140 rpm 160 rpm Lactose #316 Fast Flo Lactose 200M Maize starch Avicel PH101 Avicel PH102 Powder mass flow rate vs RMS signal Fig. 5. Mean powder mass flow rate and mean RMS signal correlation, recorded for five pharmaceutical powders conveyed using the twin screw feeder across a range of screw speeds. Powder mass flow rate vs powder velocity Conclusions Table 3. Ranking in the normalised charges recorded for five pharmaceutical powders conveyed at 100rpm. Introduction Materials & Methods Fig. 2. EPFS and measurement electronics principle of operation. References DAQ PC Balance - + - e- + + Charge output Inverting input of Op. Amp. Flow of current Summing point (virtual ground) EPFS Charged particle Flow direction Induced charge • Electrostatic induction sensors are widely used to measure in-line particle flow parameters in pneumatic conveying processes [1], but are rarely utilised in pharmaceutical flow regimes. • Triboelectrification may result in powder adhesion to processing equipment [2]. Material charging differences are typically measured using tribo-series and Faraday Cup [3]. However, tribo-series only qualitatively ranks charging behaviour specific to the conditions at which the measurements were performed, whereas the Faraday Cup cannot be integrated into processes. • In this study, an electrostatic powder flow sensor (EPFS) was developed to directly measure in-line flow parameters and charging behaviour of powders conveyed in a pharmaceutical process. EPFS Volumetric twin screw feeder (T20, K-Tron) Solid-state balance Fig. 3. Lean phase conveying system, (measurement electronics not shown). • Electrostatic and gravimetric measurements were recorded for five “as received” powders and one oven-dried powder, which were conveyed using a twin screw feeder. • Particle velocity was obtained via cross-correlation algorithm (1), using the upstream and downstream electrostatic signals. • RMS signal was calculated by averaging values across consecutive 0.05s (20Hz) intervals over the entire electrostatic dataset. • Charging behaviour was analysed by normalising the RMS of the electrostatic signal against the mass flow rate. Fig. 4. Powder deposition behaviour for a) Avicel PH102; b) Lactose #316 Fast Flo; c) Avicel PH101; d) Lactose 200M and e) maize starch. • Particle velocity was independent of the screw speed (Table 1). • Differences in the particle velocities were thought to be influenced by powder deposition sizes (Fig. 4), which resulted from differences in the cohesivity of the entrained powder. • Similar rankings were shown between particle velocity and the cohesivity dependant FT4 parameters (Table 2). • Reasonable correlation was shown (R2 > 0.88) between the mass flow rate and RMS obtained


No-code machine learning workflows and data exploration: nanoHUB’s efforts on FAIR data Juan C. Verduzco School of Materials Engineering Purdue University West Lafayette, IN, USA jverduzc@purdue.edu Daniel Mejia Network for Computational Nanotechnology Purdue University West Lafayette, IN, USA denphi@denphi.com Steven Clark San Diego Supercomputer Center University of California San Diego San Diego, CA, USA smclark@sdsc.edu Alejandro Strachan School of Materials Engineering Purdue University West Lafayette, IN, USA strachan@purdue.edu Abstract— Predictive models based on machine learning algorithms have been widely adopted across the quantitative sciences. Access barriers to advanced simulation and data tools and specialized hardware hinder progress in most scientific and engineering disciplines. While there have been advances in making research data findable, accessible, interoperable, and reusable (FAIR), scientific workflows (for machine learning, simulations, and experimental analysis) remain poorly documented and are often not accessible. Together with the need for advanced scientific computing tools and appropriate educational materials to train the next generation workforce, application of the FAIR principles on such workflows are crucial for the community’s efforts to ensure scientific reproducibility of results. nanoHUB’s mission to make scientific software useful to the research community has been evidenced in many of the platform’s efforts to remove such barriers. For example, the introduction of Sim2Ls, a novel library that allows researchers to develop and disseminate end-to-end workflows with verified and documented inputs and outputs. Making use of nanoHUB’s Sim2Ls, tool developers can document their scientific workflows, and make them available for online simulations by publishing in nanoHUB. Many journals incentivize researchers to share scripts necessary for their analysis through repositories. Using nanoHUB’s tools, developers can not only achieve that, but also create containerized versions of their environments so potential reviewers and future researchers have access to a functional ready-to-run version of their work. The contribution discussed in this presentation describes ongoing efforts in nanoHUB.org towards making scientific workflows and the data generate FAIR, as well as making data science tools available to non-experts. No-code machine learning (no-code ML) allows non-experts to model data and make predictions using advanced ML tools and algorithms though an intuitive graphical user interface available through a web-browser. Thus, users with little to no experience in code development can access predictive algorithms from their preprocessed data. Using a no-code ML approach both ensures that the ML pipeline contains all necessary steps for adequate testing and that it avoids many methodological pitfalls that can compromise reproducibility. Additionally, the use of nanoHUB’s Sim2Ls also makes the workflow and the data generated more accessible as all inputs, outputs, and results are automatically indexed and cached in nanoHUB’s ResultsDB. The ResultsDB allow for efficient caching, storage, exploration, and visualization of simulation results. Scientific workflows stored in the ResultsDB may also include metadata and details about code execution. Importantly, all data generated can be queried using simple python commands to make data accessible to the community and, at the same time, allow for further investigation in different areas of interest. Keywords—machine learning, cyberinfrastructure, scientific workflows "Presented at Gateways 2022, San Diego, USA, October 18--20, 2022. https://zenodo.org/communities/gateways2022"


The authors gratefully acknowledge the EPSRC (Engineering and Physical Sciences Research Council, UK) and Westinghouse Electric Company for their financial support. - <a> loops were present from 0.1 dpa but were not aligned along the basal planes. - Sn is known to repel <a> loops. With low Sn alloying additions in w13, Sn bands were low in concentration. Perhaps this allowed <a> loops to diffuse throughout the microstructure. - In alloys with higher Sn content such as Low Tin ZIRLO and Zircaloy-2, loop alignment becomes progressively stronger. - Discrepancies between XRD- LPA and TEM densities may be due to small <a> loops forming that were not resolvable in TEM. With increasing dose these loops grew to resolvable sizes, decreasing XRD-LPA density with no effect on TEM. - <c> loops were first observed at 12.1 dpa. They increased in density to 33.5 dpa alongside breakaway IIG. - It is proposed that <c> loops form from the transformation of larger vacancy-type <a> loops. - Cu segregated to <c> loops. Cu may diffuse to vacancies, creating Cu-vacancy pairs which later exchange with SIAs. This may help to reduce loop growth rates, delaying breakaway IIG. The effect of Cu on irradiation-induced growth mechanisms in Zr alloys following neutron irradiation C. Andrew (1), W. Zhang (2), A. Carruthers (1), R. Thomas (1), X. Liang (1), Ö. Koç (1), J. Partezana (3), M. Limbäck (3), Z. Shah (3), M. Maric (1), R. W. Harrison (1), P. Frankel (1). (1) - University of Manchester (2) - University of Oxford (3) – Westinghouse Electric Company W13 alloy composition Element Atomic Percent (at.%) Zr 98.49 Nb 0.97 Sn 0.23 Cu 0.23 Fe 0.08 Figure 1: IIG profile of neutron irradiated Zircaloy-2, Low Tin ZIRLO™ and W13 alloys SPP formation in W13 SPP type Mean Diameter (nm) Area fraction (%) Zr2Cu 277 (± 119) 0.55 β-Nb 51 (± 36) 3.40 Zr(Nb, Fe)2 117 (± 71) 1.11 2. Baseline Microstructure Characterisation 3. Irradiated Microstructure Characterisation 4. Dislocation Loop Evolution - The matrix was depleted in Cu, Nb and Fe, and enriched with Sn. - Zr2Cu, β-Nb and Zr(Nb, Fe)2 Laves phase SPPs formed in 1 µm thick bands. Zr2Cu SPPs were coarse but sparsely distributed within the bands. This SPP distribution may have affected the IIG rate of W13. Figure 3: STEM-EDS map of SPP dispersion in the W13 alloy - Zr2Cu SPPs depleted in Cu content, forming a shell from the core to the interface. - Full dissolution of Zr2Cu SPPs was observed at 33.5 dpa. - Cu formed bands along the basal planes of grains, alongside Fe and Sn. Irradiation-induced Nb SPPs formed along the basal planes as well. - Cu likely diffused along the c-axis of grains to sinks on the basal planes to create this banding structure. - Cu banding was strongest near Zr2Cu SPPs. Cu was co-segregated with Fe and anti-segregated with Sn, forming an alternating banding structure. - Segregation between Sn and Cu/Fe bands was not as strong in the matrix. This may be because of the low alloying concentrations of Sn and Fe in the W13 alloy. Additionally, as a β- stabilizer, Cu was confined to the vicinity of SPPs and was not dispersed throughout the matrix. Figure 5: STEM-EDS map of a dissolved Zr2Cu SPP at 33.5 dpa, highlighted by a blue circle Figure 10: Cu segregation to <c> loops (dotted line) at 33.5 dpa Figure 8: <c> loop evolution in the W13 alloy observed through TEM Figure 7: <a> loop evolution in the W13 alloy observed through TEM Acronyms APT – Atom probe tomography DPA – Displacements per atom SIA – Self-interstitial atom SPP – Second phase particle References (1) – R. Konings, R.E. Stoller, Comprehensive Nuclear Materials, Elsevier, 2020. (2) – P.M. Kelly, R.G. Blake, The Characterization of Dislocation Loops in Neutron l Irradiated Zirconium, Philos. Mag. 28 (1973) 415–426. (3) – G. Pan, et al. Advantages gained by Optimized ZIRLO and AXIOM PWR cladding l l materials. ANS, 2016 Figure 2: The texture of the W13 alloy via electron backscatter diffraction analysis Irradiation information Irradiation


How to represent materials knowledge? Ontology CSSI Element: Nanocomposites to Metamaterials: A Knowledge Graph Framework PI: L. C. Brinson,1 Co-PIs: C. Rudin,1 W. Chen,2 D. McGuinness,3 C. Daraio,4 L. Schadler5 Institutions: 1Duke University, 2Northwestern, 3Rensselaer Polytech. Inst., 4Caltech, 5Univ. Vermont Award #: OAC-1835677 NSF CSSI PI Meeting, Alexandria, VA, July 25-26, 2022 MaterialsMine enables materials discovery and design via an extensible digital toolkit for sharing and visualizing materials research data. Take a picture to download the full poster Nanocomposites to Metamaterials: A Knowledge Graph Framework ● Capture data “from the wild” and apply metadata that make datasets searchable and interoperable ● As of July 13th, 244 papers from the literature and 2568 total experimental samples ● MS Excel-based template contains all parameters within XML schema ● Custom-configured Excel templates facilitate entry of many samples ● Conversion tool maps data from Excel templates into corresponding fields in XML database ● Excel template and data uploader are extensible and have been shared with NIST for use in other data resources How to ingest data? Data Curation Nanomine Data Demonstrated the interpretation of the model by modifying the inputs and correlated the learning with physical understanding What can be learned from the data? NanoMine Data Case Study New insights about the interplay of interphase, volume fraction and dispersion, explaining tan d trend in experimental data within NanoMine Microstructure Characterization & Reconstruction (MCR) This work aims to produce an organized, searchable, extensible repository of data on polymer nanocomposites and structural meta- materials complete with a suite of analytical and predictive tools to help spur the discovery of new materials. Metadata include materials information, composition, processing, measured properties, microstructure, and data provenance. Data generation over a wide range of shapes & properties Data-driven metamaterials design MetaMine Data Case Study Machine learning structure-property models 88,000 2D unit cells 8,000 3D unit cells Deep learning latent shape space Intelligent Characterization Statistical Reconstruction Help users select the appropriate MCR technique and achieve microstructure information following the NanoMine schema NanoMine For Polymer Nanocomposites MetaMine For Metamaterials NLP-driven Data Curation Future work Improve the Ease of Use By the Community! Future work We are building a Natural Language Processing (NLP) pipeline with two tasks to achieve (semi-)automated curation of archival polymer nanocomposites data in journal papers. ● Preliminary work achieves a micro-averaged F1 score of 0.87 on Named Entity Recognition (NER) task. ● Collected a polymer composite corpus of 23k+ papers. ● Annotated 1896 figure captions for NER and Relation Extraction (RE) task. NLP-Driven Data Curation ● To identify samples and properties being measured to populate the structure of a Schema ● Automatic population of the schema with user verification Modification of the ontology / Knowledge Graph from a user friendly interface Materials-Information Twin Tetrahedra (MITT) The paradigm shift toward data-intensive scientific research relies on collaboration between numerous disciplines and stakeholders. ● MITT is the nexus joining materials and information science, adapted from the concept of a “digital twin” ● Provides stakeholders with a platform to contextualize, translate, and direct efforts for next generation materials science advances QR Code Here Glass transition temperature (Tg) is tunable by changing the chemistry of the interface between the nanoparticles and polymer matrix. A case study using NanoMine and the Polymerizer web tool to investigate the relationship of the shift in Tg and parameters such as nanoparticle volume fraction and surface energies showed: ● Machine Learning could be used to show a quantitative relationship between s


Seasonal prediction in northern Atlantic Ocean and Norwegian Seas Noel Keenlyside1,2,3, Sunil Pariyar1,3, Ingo Bethke1,3, Yiguo Wang2,3, and Francois Counillon2,3 1University of Bergen, Geophysical Institute, Bergen, Norway, 2Nansen Environmental and Remote Sensing Center, Bergen, Norway, 3Bjerknes Centre for Climate Research, Bergen, Norway 1. Main research question: What are the sources of seasonal SST prediction skill of NorCPM over the North Atlantic? 2. Model and data Norwegian Climate Prediction Model version 1 with Ensemble Kalman Filter data assimilation method  Historical simulation: 30 ensemble members  Hindcasts: decadal hindcast starting in 15 October (10 ensemble members)  NOAA OI-SST (1982-2018) 3. SST prediction skill 4. Contribution from low (>5-years) frequency variability 4. Contribution from external forcing and internal variability 5. Role of Ocean (Annual ocean heat budget) Fig. 1. Monthly anomaly correlation coefficients between NorCPM hindcasts and NOAA-OI SST from 1982 to 2018 Fig. 2. Monthly anomaly correlation coefficients between NorCPM hindcasts and NOAA-OI SST from 1982 to 2018 based on 5 years lowpass filtered data Fig. 4. Annual SST tendency variance explained (%) by column integrated heat divergence and net surface heat flux Fig. 3. Monthly anomaly correlation coefficients between NorCPM hindcasts and NOAA-OI SST from 1982 to 2018. The total skill is separated into internal variability (top panel) and external forcing (bottom panel).


Analysis of Herbal Dietary Supplements Gwyndolyn Jones, Katie Wiley, Morgan Shirley, Reed Eisenhart, Tom Linz, Robert Dunn Department of Chemistry, The University of Kansas The use of herbal supplements is a growing trend in the United States. Americans spent over 22 billion dollars on herbal supplements alone in 2006. Under the 1994 Dietary Health Act, only prescription and over-the-counter drugs are regulated and require FDA approval, so there are no mandatory requirements for safety or quality testing of herbal supplements. Some manufacturers adulterate their products with pharmaceuticals or other synthetic compounds to enhance their effects without any clear remark on the ingredient table. This research speciﬁcally investigated male sexual enhancement drugs, and weight loss pills claiming to contain “Hoodia”, a cactus extract thought to suppress appetite. For the male sexual enhancement drugs, our concern was whether the manufacturers illegally adulterated their products with prescription drugs, such as sildenaﬁl [Viagra®], tadalaﬁl [Cialis®], and vardenaﬁl [Levitra®]. Using HPLC-MS and UV-Vis, we have identiﬁed and quantiﬁed the presence of those compounds in the pills. For the weight loss products claiming to contain “Hoodia,” our concern was whether manufacturers adulterated their products with synthetic compounds known to increase metabolism and suppress appetite, such as caffeine and chromium. We have identiﬁed and quantiﬁed the presence of caffeine, chromium, and the active ingredient in Hoodia, steroidal glycoside P57, using HPLC-MS and graphite-furnace AAS. ! Abstract Background: Herbal Supplement Study 1: Male Enhancement Pills Acknowledgement Robert Dunn Tom Linz • Under the 1994 Dietary Health Act, only prescription and over-the-counter drugs are regulated and require FDA approval • Over $40 billion is spent each year on herbal supplements in U.S. • FDA is responsible for taking action against any unsafe dietary supplement product, however they can only investigate products after they reach the market • Last year, FDA investigated 80 dietary supplement marketers recalling illegal products resulting from mislabeling Problems with Herbal Supplement • Prescription pharmaceuticals have been found in herbal supplements, creating problems for the consumer • interactions with medication • allergic reactions • side effects • If Viagra is taken with certain other drugs, the effects of either could be altered • Erythromycin (E-Mycin, Ery-Tab, PCE) • Itraconazole (Sporanox) • Nitrates such as Isordil, Nitro-Bid, and Nitro-Dur Rifampin (Rifadin, Rimactane) • Overdose of chromium can cause several effects stomach, liver, kidney, and lung damage • irregular, fasten heart rhythm • inhibits insulin Objectives • Male enhancement supplements: This group will focus on the contamination of herbal supplements with pharmaceuticals, speciﬁcally male performance supplements that have been adulterated with sildenaﬁl citrate (Viagra®), vardenaﬁl (Levitra®) and tadalaﬁl (Cialis®) • Weight loss supplements: This group will focus on the use of Hoodia in weight loss pills to determine if the active ingredient P57 is in the actual pill and if the pill has been contaminated with other known appetite suppressants Study 2: Weight Loss Pills Male Enhancement Pills 100% Natural and Herbal Extract Pills that we tested Research of Interests Research of Interests Sildernafil Quantification Tadalnafil and Vardenafil Conclusion Chromium Quantification Caffeine Quantification Conclusion P57 Identification Sildenaﬁl Viagra® Vardenaﬁl Levitra® Tadalaﬁl Cialis® • Synthetic molecules not found in nature • Prescription medicine • Warning is required if you are taking nitrates that might lower blood pressure leading to a heart attack. More reports are linking Tadalaﬁl to stokes. • Pills were dissolved in methanol • Calibration curve was ﬁrst constructed • HPLC-UV/MS, UV-Vis were used • LOQ and LOD were determined as 15 ng and 3 ng for MS selected ions • Minim


Compact, Quality-Preserving Energy Booster for Intense Laser-Plasma Ion Sources M. Garten, S.S. Bulanov, S. Hakimi, L. Obst-Huebl, C.E. Mitchell, C. B. Schroeder, E. Esarey, C.G.R. Geddes, J.L. Vay and A. Huebl Lawrence Berkeley National Laboratory, Berkeley, CA, USA This material is based upon work supported by the Defense Advanced Research Projects Agency via Northrop Grumman Corporation. Partly supported by the U.S. DOE FES Postdoctoral Research Program, administered by ORISE under contract DE-SC0014664, the U.S. DOE Office of Science Offices of ASCR, HEP and FES (incl. LaserNetUS) under Contract No. DE-AC02-05CH11231, the Scientific Discovery through Advanced Computing (SciDAC) program, and the Exascale Computing Project (17-SC-20-SC). This research used resources of the Oak Ridge Leadership Computing Facility at the ORNL (DE-AC05-00OR22725, ALCC program) and the National Energy Research Scientific Computing Center (DE-AC02-05CH11231, FES-ERCAP0024250). We thank R.T. Sandberg, D. Terzani, R. Lehe and J. Qiang for helpful discussions. Simulations used the open source particle-in-cell code WarpX in version 23.01. We acknowledge all WarpX contributors. DOI:10.5281/zenodo.11217273 Laser-Plasma Ion Sources unique, pulsed, ultra-intense TE Cowan et al., PRL 92 (2004) F Wagner et al., PRL 116 (2016) A Higginson et al., Nat. Comm. 9 (2018) M Rehwald et al., Nat. Comm. 14 (2023) T Ziegler et al., Nat. Phys. (2024) First Quality-Preserving Plasma Staging Concept for Ultra-Intense Ion Bunches M Garten et al., "Laser-Plasma Ion Beam Booster Based on Hollow-Channel Magnetic Vortex Acceleration", under review, arXiv:2308.04745 (2024) ✓open-source development ✓scalable multi/manycore CPUs/GPUs from laptop to ExaFlop/s supercomputer ✓multi-platform Linux, macOS, Windows ✓multi-disciplinary ✓extensive documentation ✓large & active community Full 3D Simulations show robustness & capture efficiency WarpX is part of the Beam, Plasma & Accelerator Simulation Toolkit Electromagnetic particle-in-cell modeling of laser-plasma physics includes all relevant relativistic and kinetic effects from first principles. WarpX is developed by leveraging expertise in physics, applied math & HPC in collaboration with US and international collaborators. We organize in Open Governance and join the: Created in laser-plasma interaction, driven by laser intensities ≈1023 W/cm2 ●ultra-low emittance (≪ 20 nm) ●very high charge (≫ 100 pC) ●large current (> kA) ●ultra-short (10s of fs) ●TV/m fields for compact acceleration length (≈ few μm). With current short-pulse Petawatt laser facilities, laser-ion acceleration remains an indirect process due to the high mass of ions compared to plasma electrons. Experiments demonstrated 150 MeV / u. Maximum proton energy for selected laser-ion acceleration mechanisms. Ref.: S Hakimi et al., PoP 29 (2022) Temporal & Spatial Tolerance energy boost and capture efficiency are within experimentally achievable tolerances & source parameters Magnetic-Vortex-Acceleration combines strong ●accelerating and ●focusing fields with 10s of MV/μm. At BELLA iP2, first experimental campaigns that explore MVA as a source are underway. Now, a plasma ion accelerator will need booster elements, too! We propose a new concept & self-consistent numerical proof: plasma staging of sub- to fully relativistic ion beams. Modified MVA stage with a pre-formed hole supresses low-energy ion injection – instead boosts a well-timed, external ion beam. Self-consistent 3D modeling, boosting a space-charge dominated 200 pC proton beam (35 kA, dƐ=5%). Quality-preserving: ✓charge (perfect) ✓emittance (+3.5nm) ✓energy spread (+2%) Outlook pivotal applications, realization in current or near-term laser facilities, interstage transport L Obst-Huebl et al., SPIE (2023) AD Piazza et al., MP3 workshop report (2022) S Busold et al., TUME030, IPAC14 and NiMA 740 (2014) and Sci. Rep. 5 (2015) Could boost laser-ion beams relevant to fundamental research & applications, e.g., futu


Data-Depositing in der Task Area Collections Ein zentraler Baustein des NFDI-Konsortiums Text+ ist die Entwicklung einer Infrastruktur für die langfristige Bereitstellung und Archivierung von nachnutzbaren text- und sprachbasierten Forschungsdaten. An der verteilten Infrastruktur von Text+ beteiligen sich verschiedene Daten- und Kompetenzzentren mit ihrer je eigenen Expertise zu bestimmten Datentypen. Die elf Zentren der Task Area Collections gliedern sich in drei Cluster: gegenwartssprachliche Daten, historische Texte und unstrukturierte Texte. Zur Datenhaltung nutzen sie zertifizierte Repositorien. Durch die Aufnahme von Daten in eine der an Text+ beteiligten Einrichtungen wird eine nachhaltige Datenhaltung (gemäß FAIR/CARE) sichergestellt und die Nachnutzbarkeit (z.B. über LRS, Geo-Browser) sowie die Auffindbarkeit über zentrale Nachweissysteme erhöht. Wohin damit? Wir geben Ihren Daten ein Zuhause Collections Lexical Resources Editions Infrastructure/ Operations The NFDI consortium Text+ is funded by Deutsche Forschungsgemeinschaft (DFG), project number 460033370. Text+ is part of https://www.text-plus.org Beteiligte Daten-/Kompetenzzentren Christoph Draxler (LMU München), Philippe Genêt (Deutsche Nationalbibliothek), Marius Hug (Berlin-Brandenburgische Akademie der Wissenschaften), Timm Lehmberg (Akademie der Wissenschaften in Hamburg), Thorsten Trippel (IDS Mannheim, Universität Tübingen) Datenzentrum Spezialisierung Berlin-Brandenburgische Akademie der Wissenschaften (BBAW): Deutsches Textarchiv ●deutschsprachige Texte (ca. 1600–1920) ●hochwertige Transkriptionen/Metadaten ●strukturiertes Textformat und offene Lizenz Deutsche Nationalbibliothek (DNB) ●in Deutschland erschienene Publikationen und Tonträger ●Werke, die in deutscher Sprache erstellt wurden oder einen Bezug zu Deutschland haben Gesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen (GWDG): Text+ Langzeitarchiv ●alle Daten mit geisteswissenschaftlichem Bezug Leibniz-Institut für Deutsche Sprache (IDS) ●geschriebene und gesprochene neuhochdeutsche Sprache ●linguistisch annotierte Korpora ●Deutsch in nicht-primär deutschsprachigen Ländern Ludwig-Maximilians-Universität München: Bayerisches Archiv für Sprachsignale Repository (BAS) ●gesprochene Sprache mit zeitalignierter Annotation ●Repository und sprachtechnologische Webdienste für Grundlagenforschung und Technologieentwicklung Niedersächsische Staats- und Universitätsbibliothek Göttingen (SUB): DARIAH-DE Repository; TextGrid Repository ●geistes- und kulturwissenschaftliche Forschungsdaten aller Typen ●Fokus auf XML TEI-kodierte Texte und Bilder Universität des Saarlandes (SLUni): Repositorium für Sprachressourcen ●annotierte Korpora geschriebener Sprache ●fremdsprachliche und multilinguale Sprachkorpora (parallele und vergleichbare Korpora) ●registerspezifische Korpora Universität Duisburg-Essen (UniDUE): Kompetenzzentrum für parlamentarische Sprachdaten ●Aufbereitung, Bereitstellung und Analyse von parlamentarischen Sprachdaten ●Verknüpfung (Data Linkage) Universität Hamburg (UniHH): Hamburger Zentrum für Sprachkorpora (HZSK), Akademie der Wissenschaften in Hamburg ●Interdisziplinarität und linguistische Diversität ●Korpora gesprochener Sprache Universität Tübingen (UniTÜ): Tübingen Archive of Language Resources (TALAR) ●Baumbanken/Treebanks ●Wortnetze ●Word-Embeddings Universität zu Köln (UniK): Data Center for the Humanities Köln ●Audiovisuelle Sprachkorpora, Oral Literature Sammlungen ●Datenarchivierung (Dark & Cold Archiving) ●Automatisierte Datenpublikation via Zenodo Gegenwartssprachliche Daten ●soziolinguistische Interviewdaten ●Dokumentation des Sprachwandels ●Anwendungsorientierte Sprachdaten ●... Historische Texte ●Novellen aus dem 19. Jahrhundert ●Briefkorpus (1745–1872) ●Pesttraktate (1473–1700) ●... Unstrukturierte Texte ●Online-Hochschulschriften ●E-Journals ●E-Books ●... Daten mit geisteswissenschaftlichem Bezug ●Projektergebnisse (PDF, TEI, METS, IIIF etc.) und sonstige Projektda


Secure sharing of molecules and bioactivity data using mobile apps. The technologies already exist that enable the scientist to securely share molecule structures or structure-activity relationship (SAR) tables for multiple molecules with one or more other scientists (perhaps even a group). This can be done for a very small investment. We now describe how just 2 commercial cheminformatics apps can enable such sharing at very reasonable cost ($25). SAR Table: A specialized editor for building tables containing an homologous series of scaffolds and substituents, creating composite structures, and providing activity data. Can be used to prepare figures for manuscripts, or to recreate data from the literature. MolSync: A chemistry-aware client for remotely stored files hosted by Dropbox. Provides viewing and editing capabilities, as well as serving as an intermediary for sharing content with other apps. It can also be used to explicitly synchronize data with other apps. Molecules can be sketched in SAR Table and then shared via MolSync. MolSync enables files to be readily deposited in DropBox folders. This cloud-based storage facility provides a free capability to share (securely) limited amounts of data with selected individuals. This approach represents a very cost effective way to enable secure chemistry and bioactivity data sharing. When data is ready to be shared openly a third mobile app can be used. The Open Drug Discovery Teams (ODDT) project uses a free mobile app as the user entry point http://tinyurl.com/6l9qy4f. The app has a magazine-like interface, and server-side infrastructure for hosting chemistry-related data as well as value added services. The project is open to participation from anyone and provides the ability for users to make annotations and assertions, thereby contributing to the collective value of the data to the engaged community. The infrastructure for the app is currently based upon the Twitter API and uses Google Alerts RSS feeds as a useful proof of concept for a real time source of publicly generated content. Using Twitter, users can easily push data from SAR Table or MolSync into ODDT. Secure Sharing with Mobile Cheminformatics Apps Followed by Open Publication When Ready Sean Ekins1 and Alex M. Clark2 1 Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay Varina, NC 27526, U.S.A., 2 Molecular Materials Informatics, Montreal, Quebec, Canada H3J 2S1. B http://collabchem.com User tweets with #leishmaniasis The App Content from web Links to papers, blogs, websites Get ODDT here for free When ready for public sharing push to ODDT Showing molecule and bioactivity data export to Molsync Showing data in Dropbox and how its limited access Showing how when ready, a subset or all data can be tweeted to ODDT


1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic; 2 Department of Statistical Modelling, The Czech Academy of Science, Czech Republic; 3 Department of Geriatrics and Gerontology, 1st Faculty of Medicine, Charles University, Czech Republic Correspondence: jovanabrkic37@gmail.com; gajdosp1@faf.cuni.cz; veronika.kubikova11@gmail.com; jreissigova@seznam.cz; fialovad@faf.cuni.cz Jovana Brkić1, Petra Gajdošová1, Veronika Kubíková1 , Jindra Reissigová2 , Daniela Fialová1,3 Introduction Potentially inappropriate prescribing, including prescribing potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), is highly prevalent in older adults.1-7 The aim of our study was to determine the prevalence of cardiovascular (CV) PIM use in older patients admitted to acute care in the Czech Republic. This poster presents preliminary results of in-progress research within Horizon 2020 EuroAgeism project (10 countries, 4500 patients) and relates also to the scientific work of the European INOMED project. Analyses of potentially inappropriate cardiovascular medication use in acutely hospitalized older patients in the Czech Republic Methods The data for this preliminary analysis were collected at two acute care geriatric departments in two bigger cities in the Czech Republic (Brno and Hradec Kralové) from August 2018 to January 2019. Patients admitted to geriatric wards were assessed, excluding subjects severely cognitively impaired (Mini-Mental State Examination, MMSE <10), terminally ill or admitted to the intensive care unit. Data were collected from medical records and interviews with healthcare professionals and patients using a comprehensive instrument. Several scales of interRAI Organization were used for assessment of functional status, namely Depression Rating Scale (DRS), Cognitive Performance Scale (CPS) and ADL and IADL hierarchy scales. Also, other information related to diseases, symptoms, medication use, utilization of healthcare services, and satisfaction with care provision were collected. CV PIM use was assessed by trained researchers using several consensus‐based explicit criteria, namely Screening Tool of Older Person’s Prescriptions (STOPP)3, Screening Tool to Alert doctors to the Right Treatment (START)3, EU(7)-PIM list4 and Beers criteria 20195. In total, 99 individual criteria were applied. The study was approved by the Ethical Committee of the Charles University, Faculty of Pharmacy and by Ethical Committees of participating acute care hospitals. Results Of the 288 patients assessed, 57 % (164) were women. The patient age distribution was as follows: 35.8 % were 65-74 years, 35.4 % were 75-84 years, 27.1 % were 85-94 years and 1.7 % were 95 years and older. Overall, 77.6 % of patients were exposed to CV PIMs. The highest prevalence of CV PIMs was identified by START criteria (63.2 % of older patients), followed by EU(7)-PIM list (31 %). The lowest prevalence was documented using Beers criteria 2019 (16.1 %). (see Tables 1,2,3) Conclusion The use of CVS PIMs is highly prevalent in older hospitalized patients in the Czech Republic. The results varied according to different criteria and the highest prevalence was identified by START criteria. We intend to conduct further analyses using data of the whole Horizon EuroAgeism H2020 project when data collection is finalized in December 2020. For more information on Horizon 2020 EuroAgeism and INOMED projects visit websites:https://portal.faf.cuni.cz/Projects/Euroageism-Project/; https://portal.faf.cuni.cz/Careers/InoMed- Researcher-201910/ Tables 1) Prevalence of patients with 1+ CV PIM 2) Prevalence of patients using 0,1,2,3,3+ CV PIMs 3)Top 3 most often used CV PIMs Literature cited 1.O’Connor et al. Drugs Aging. 2012. 2. Fialová et al. Eur J Clin Pharmacol. 2019. 3. Fialová et al. J Am Med Assoc. 2005. 4. Gallagher et al. Eur J Clin Pharmacol. 2011. 5. Morin et al. J Am Med Dir Ass


Design of the TUMBLE chamber’s turbulence generator • The chamber TUMBLE studied by Le Dortz [2] was modified in order to be able to control the turbulence intensities and the turbulent length scales. • Based on literature review [3], a set of 3 perforated plates were chosen. Introduction IWPD and ICVDCW 2022 August 15-19, 2022 Berlin, Germany Experimental characterization of ignition events in CVC like conditions M. C. de Jesus Vieira, J. Sotton, M. Bellenoue, C. Strozzi maria-clara.de-jesus-vieira@ensma.fr Institut Pprime, CNRS, Université de Poitiers, ISAE-ENSMA, F-86962 Futuroscope Chasseneuil, France Concepts and project overview Concepts and project overview Conclusion and perspectives • Since early development, the thermodynamic cycle used in gas turbines has undergone little change. Over the last decades, an effort has been put into increasing efficiency by reducing losses and raising the overall pressure ratio and peak temperature. One of the most promising new types of cycles is the case where a pressure rise across the combustion process is allowed (CVC). In this case, an ignition in each cycle will be considered and also diluted mixtures with high mean velocities and turbulent flows. The main objective of this work is to experimentally investigate the different phenomena involved in the ignition stage in a CVC application, such as the effect of the dilution by a residual burned gas (RBG), the turbulence intensity, and turbulence length scales. • For this purpose, a lab-scale facility was developed to generate turbulent flow and to allow electrical energy measurements. The setup will allow a well-controlled flow, with the possibility to vary the mean velocity and turbulent scales. The ignition system's energy and power effects on the ignition process will be studied. Definition of RBG composition • In order to define the composition of the synthetic RBG, the main flame properties were analyzed (𝑇𝑏, 𝑆𝐿, 𝛿) • Mixture: Propane/air - 𝜙= 0,7, P = 1 bar and 2 bar and ambient temperature. • The calculations were made using Cantera with the San Diego chemical mechanism [1]. • The mixture chosen was so that the heat release from the RBG produced would be the same. • Synthetic RBG dilution mixture chosen: 5% He + 95% N2 (without H2O). • A mixture of 5% He + 95% N2 is adequate and behaves as a residual burned gas. • The perforated plate design describes the desired turbulence intensity profile. • Optical diagnostics will be made to characterize the turbulence and ignition in the chamber. • MIE [1] measurements will be performed for a propane/air mixture with synthetic RBG dilution. with the new turbulence generator. • For spark duration lower than 0.4 ms, a smaller calorimetry chamber could be used. References [1] Chemical - Kinetic Mechanisms for Combustion Applications, San Diego Mechanism web page, Mechanical and Aerospace Engineering (Combustion Research), University of California at San Diego. http://combustion.ucsd.edu [2] R. le Dortz, “Détermination des caractéristiques fondamentales de combustion de pré-mélange air-kérosène, de l’allumage à la vitesse de flamme : représentativité de surrogates mono et multi-composants.” Thesis. Ecole nationale supérieure de mécanique et d'aérotechnique. [3] N. Mazellier, L. Danaila, and B. Renou, “Multi-scale energy injection: A new tool to generate intense homogeneous and isotropic turbulence for premixed combustion,” Journal of Turbulence, vol. 11, pp. 1–30, 2010, doi: 10.1080/14685248.2010.519708. [4] C. C. Huang, S. S. Shy, C. C. Liu, and Y. Y. Yan, "A transition on minimum ignition energy for lean turbulent methane combustion in flamelet and distributed regimes," Proceedings of the Combustion Institute, vol. 31 I, no. 1, pp. 1401–1409, 2007, doi: 10.1016/j.proci.2006.08.024. [5] C. J. BENITO PAREJO. “Experimental Characterization of Electrical Discharges and Formation of the Ignition Kernel. Application to the Study of Performances of Aeronautical Igniters”. 2019. Thesis. Ecole n


1Biomedical Center, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany; 2John Curtis School of Medical Research, Australian National University, Canberra, Australia.3Center for Integrated Protein Science Munich, Department of Chemistry, Munich, Germany Splicing factor Scaf6/CHERP regulates muscle development in Drosophila Shao-Yen Kao1, Keshika Ravichandran1, Rippei Hayashi2, and Maria Spletter1,3 2. Scaf6/DmCHERP is conserved among species D. melanogaster SCAF6 D. rerio CHERP M. musculus CHERP H. sapiens CHERP SWAP RPR RS domain G-parch 3. Scaf6 is expressed in ﬂy ﬂight muscle (IFM) and neuron nucleus 500 400 1000 1500 RC RA RE 30hr APF 72hr APF 1d Adult Age: Scaf6-PA Scaf6-PE Scaf6-PC RT-PCR in IFM Actin, DAPI, Myc-Scaf6 30hr APF 72hr APF 1d Adult RT-PCR in Neuron Elav, DAPI, Myc-Scaf6 Overexpression in neuron Overexpression in IFM 0 10 20 30 40 50 60 70 80 90 100 Survival Righting reflex Climbing Flight Grooming Performance percentage WT Scaf6 Mutant Mef2> Scaf6-IR Elav> Scaf6-IR Mef2, Elav>Scaf6-IR Actin5C>Scaf6-IR Tublin>Scaf6-IR 4. Tissue-type selectivity of Scaf6 function in ﬂy Lethal in pupa stage WT Scaf6 Mutant Mef2> scaf6-IR WT Scaf6 Mutant Mef2> scaf6-IR 0 1 2 3 4 Micron Sarcomere length 48hr APF 72hr APF WT Scaf6 MT Mef2> IR Flight muscle 48hr 72hr WT Scaf6 MT Mef2>IR *** p=0.06 5. Scaf6 is necessary for ﬂight muscle b. Scaf6 regulates myoﬁbril development a. Scaf6 knockdown in myoblast loss muscle ﬁbers (Nikonova and Kao, 2019) 1. RNA binding proteins in muscle 6. Scaf6 regulates splicing in IFM muscle Selected GO enrichments a. Scaf6 regulates alternative splicing Mhc Mhc WT Mutant Mef2> W- Mef2>scaf6-IR Zasp66 WT Mutant 0 36 73 110 146 Zasp66 Mef2> W- Mef2>scaf6-IR Intron retention Exon usage changes c. Selected target gene expression at protein level in Scaf6 mutant b. Spliced junction changes in Scaf6 mutant Novel spliced event Sls WT Mutant RT-PCR of veriﬁcation Sls novel event 500bp 100bp DNA control WT Scaf6 Mutant Thorax Thorax Head Head • Scaf6 plays functional roles in muscle and nervous system in selective perspectives • Scaf6 functions in myoblast and myofibril development • Scaf6 regulates RNA splicing dynamic in developing IFM and repress intron retention • Tell me know what your thought!! Contact me: shao-yen.kao@bmc.med.lmu.de Conclusion: 7. LOF of Scaf6 impaired developing muscle contraction WT Scaf6 Mutant 48hr APF time 0.0s time +1.2s no movement n=27 WT Scaf6 Mutant % Muscle twitch n=18 0 10 20 30 40 50 60 70 80 90 100 WT Scaf6 Mutant Mef2>IR 1151>IR Him>IR Salm>Scaf6-IR # of muscle ﬁber 6 5 4 3 (%) 1151, Him: Myoblast speciﬁc; Salm: after 24hr APF (Muscle driver) (Neuron driver) APF: After puparium formation Whole body (Muslce+Neuron?) Neuron Neuron Neuron>Muscle Muscle>Neuron


Getting streamlined elaboration of feature tables with separated quality controls, advanced statistics such as linear model with mixed effects, and more: presenting the “GetFeatistics” R-package Gianfranco Frigerio1,2,3 1 Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, Italy 2 Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg 3 Department of Clinical Sciences and Community Health, University of Milan, and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy 20th Annual Conference of the Metabolomics Society – METABOLOMICS 2024 – Osaka, Japan, 16th -20th June 2024 The package is on GitHub: https://github.com/FrigerioGianfranco/GetFeatistics I acknowledge Albina Rastoder for helping with the testing of some functions, during her 2 months internship at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg. I also acknowledge Prof. Dr. Emma Schymanski for the support and suggestions and the entire Environmental Cheminformatics group of the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg for the help and feedback. I acknowledge funding support from the Luxembourg National Research Fund (FNR) for project A18/BM/12341006. frigerio.gianfranco@hsr.it Any questions? Write me!!! ☺ Gianfranco Frigerio @gianfrancofrig1 Gianfranco Frigerio Within the metabolomics community, tools such as MS-DIAL and R-based algorithms as XCMS are widely implemented to convert raw data to feature tables. As demonstrated in a previous work, while conducting non-targeted metabolomics studies with defined groups of subjects assessing variations of molecules present at low concentrations (such as metabolites of exogenous compounds) the use of separated pooled quality control (QC) samples can be a promising strategy to both improve the quality of the dataset and preserving potential features deriving from low concentrated molecules. Moreover, in observational epidemiologic studies, controlling for confounding factors is crucial to assess the association of metabolite variations with the biological question of interest; also, for longitudinal studies, linear models with mixed effects are a great statistical approach. Targeted analyses Non-targeted analyses featTable featINFO get_feat_info_from_MSDial • featTable: table with feature intensities • featINFO: table with rt, m/z and potential annotations get_targeted_elaboration Given a tables containing data from targeted analyses, including a calibration curve and internal standards, it calculates the concentrations in unknown samples. test_normality_density_plot test_normality_q_q_plot test_normality_saphiro_table transf_data To replace missing values, log-transform, and/or scale the data. gentab_P.1wayANOVA_posthocTurkeyHSD It performs one-way ANOVA, with also TurkeyHSD posthoc tests for between-groups comparison, to each desired variable and creates a new table with the p-values gentab_P.2wayANOVA_posthocTurkeyHSD It performs 2-way ANOVA, with also TurkeyHSD posthoc tests for between groups comparison, to each desired variable and creates a new table with the p-values addINFO_to_table Given a table containing data related to features (for example the output of a statistical analyses) and the related featINFO table, it combines everything in a single table. It removes special characters from a character vector Given a dataframe and a set of dependent and independent variables from that dataframe, it generates a linear regression model for each single dependent variable and creates a new table with all slopes and p-values. plot_calibration_curves It creates plots of the calibration curves from a targeted elaboration. Statistical analyses Functions to test normality, by producing density plot, q-q-plot and performing Shapiro test get_feat_info_from_patRoon get_feat_table_from_MSDial get_feat_table_from_patRoon From MS-DIAL output or from patRoon output, it


Public Health, Markets and Law Call for abstracts COMPHACRISIS is pleased to announce the Public Health, Markets and Law workshop, which will be held on Friday, 29 September 2023, at UCD Sutherland School of Law, Dublin. This workshop aims to bring together experts from different disciplines, including economics, law, marketing, political economy, public health and sociology, to discuss and share their perspectives and insights on public health, markets and law. Keynote: Ms Anna Vernet (EU Commission Head of Unit, Antitrust, Pharma and Health Services) Confirmed Speakers and Chairs: • Professor Susie Geiger (UCD College of Business) • Dr Łukasz Grzejdziak (University of Strathclyde) • Dr Cliona Kelly (UCD Sutherland School of Law) • Professor Cecily Kelleher (UCD College of Health and Agricultural Sciences) • Dr Mary Catherine Lucey (UCD Sutherland School of Law) • Professor Aisling McMahon (Maynooth University) • Dr Enrique Sanjuán y Muñoz (Court of Appeal of Málaga)) • Dr Carmen de Vivero de Porras (Universidad de Málaga) • Professor Helen Roche (UCD Vice President for Research, Innovation and Impact ) Organisers: Dr Mina Hosseini and Professor Imelda Maher We invite submissions that address the following themes: • Competition law and health markets • Exploring the EU pharmaceutical sector through a multidisciplinary lens • Intellectual property law and public health • Legal and regulatory responses to the COVID-19 Pandemic • Future of health markets • A multidisciplinary perspective on the pharmaceutical strategy for Europe or any other research issue in this area Papers should be original, not previously published or under consideration for publication elsewhere. We welcome abstracts from researchers at all stages of their careers, including early career researchers and PhD students.


What Came First: The Paper or the Data? Measuring data reuse and metadata re-curation is important for understanding and finding examples of repository behaviors. Comparing connected article and dataset publication dates may provide helpful measures and visualizations. These connection timelines are for repositories holding datasets that are connected to articles that acknowledge funding by NSF. They provide a limited view that may not be representative of the entire repository. Data retrieval and processing are described here. Reuse occurs when data exists before articles referencing it are published. In these cases the connection median difference (y-axis) is above 0. Curation occurs when data and articles are published at the same time. In these cases the connection median difference (y-axis) is 0. Re-Curation occurs when articles exist before the data they reference gets a DOI. In these cases the connection median difference (y-axis) is below 0. Data from CHORUS (https://www.chorusaccess.org) Funded by the U.S. National Science Foundation, award 2134956 Ted Habermann, Erin Robinson, Metadata Game Changers


The analysis of 3C 47 has resolved a longstanding conundrum dating back to the 1990s: the CIVλ1549 broad- line profile in the UV spectra of radio galaxies often appeared as narrow as or narrower than the Hβ line. The interpretation provided by 3C 47, involving an accretion disk and a failed wind, offers an explanation. In many cases, the disk contribution could be completely masked. The “double-peakers,” which are most frequently found at the extremum of the Eddington ratio (minimum radiative output per unit mass) on the quasar main sequence, may all be due to the trimming of the emitting region by a second black hole. Accretion disk and wind emission in the Population B, jetted quasar 3C 47 Paola Marziani1, Shimeles Terefe Mengistue2,3,4, A. del Olmo5, M. Povic5,6, J. Perea5, and A. Deconto Machado5 1National Inst. for Astrophysics (INAF), Oss. Astron. di Padova, Padova, Italy; 2Space Science and Geospatial Inst. (SSGI), Addis Ababa, Ethiopia; 3Addis Ababa Univ., Addis Ababa, Ethiopia; 4Jimma Univ., Jimma, Ethiopia; 5IAA (CSIC), Granada Spain; 6Mbarara Univ. of Science and Technology (MUST), Mbarara, Uganda An optically thick, geometrically thin accretion disk around a supermassive black hole might contribute to broad line emission in type-1 active galactic nuclei (AGN). We show that the double-peaked profiles of the strongest low-ionization lines (LILs) in the 3C 47 optical spectrum can be explained by a relativistic Keplerian accretion disk model. The profiles of prototypical high ionization lines (HILs) such as CIVλ1549 were also modeled by the contribution of the accretion disk, but required an additional component, possibly due to a failed wind. The observations of 3C 47 suggest an intriguing hypothesis for the origin of the “double-peakers,” sources found at the low end of radiative power per unit black hole mass along the quasar main sequence. Intriguing profile variability Conclusion A binary black hole, after all? Relativistic accretion disk plus a failed wind? 𝛺 𝛺 30 kpc Orbital plane of the secondary Equatorial plane of the primary Reference 3C47 The double-peaked profile of Balmer lines is modeled using a relativistic AD emission profile, following the approach of Chen & Halpern (1989, ApJ, 344, 115), and using a fully Bayesian technique. The single-peaked CIVλ1549 profile can be attributed to the AD plus a strong central feature. The flat spectral energy distribution of 3C 47, dominated by synchrotron and synchrotron-self-Compton emission, results in the over-ionization of the gas. This over-ionization leads to a lower force multiplier, which may contribute to the formation of a failed wind. Force multiplier 3C 47 Typical AGN The available observations, though sparse, reveal intriguing variability patterns and changes in peak shift amplitude. The periods inferred from these shift variations suggest masses exceeding that of the primary black hole. The hypothesis that the double-peaked structure is due to two black holes, each with its own broad line region giving rise to an almost Gaussian component, is not favored. The VLA radio map (Fernini et al. 1991, ApJ, 381, 63) shows an intriguing misalignment between the hot spot and the lobe- counter-lobe axis. The geodetic precession period can be shorter than, or comparable to, the dynamical timescale of the radio source, if precession is induced by a second, smaller- mass black hole between the outer disk edge (r ~ 103 rg) and the torus inner edge(r ~ 104 rg), with an orbital plane inclined by 15o with respect to the equatorial plane of the primary. AD AD+failed wind Ionization structure MBH ~ 7 109 M⦿ tdyn ~ 6 107yr


Helping researchers get started with Patient Engagement (PE) Observation  Implementation Increases the quality, patient relevance and societal acceptance of research and its results Empowers patients and therefore impacts their well-being Potentially increases eligibility for a funding grant To help researchers get started with PE a special “Starter Pack” compiled One central place for all researchers’ PE needs Already existing information is curated and organised in an easy-to-find way Feedback from researchers is that it’s difficult to understand where to begin Multitude of resources out there is overwhelming and makes it complicated to navigate the subject Resources out there exist in silos and are fragmented patient-engagement.eu Ask a question Submit a resource Help us disseminate Watch video stories Patient Engagement Resource Centre (PERC) is developed with the funding from EATRIS-Plus Project (GA No 871096). It has been developed jointly between the European Infrastructure for Translational Medicine (EATRIS), the European Patients’ Forum (EPF) and the European AIDS Treatment Group (EATG). The PERC is intended as guidance and should be considered as advice only. Video Stories Get involved PE in basic science of lung fibrosis developed workshops to improve bilateral understanding PE in rare progressive liver disease (PSC) organised workshops on knowledge sharing & manuscript co- developed PE in rare ovarian tumours fundamental collaboration in bridging the gap in understanding and triggering scientific breakthroughs Why Patient Engagement? Resources This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 871096 Developed by


This project has received funding from the European Union‘s Horizon 2020 research and innovation programme under grant agreement No731031. operas-eu.org pierre.mounier@openedition.org Created by Elisabeth Heinemann Digital Humanities Officer at Max Weber Stiftung OPERAS Communication Officer 300 geistes- & sozialwissenschaftl. Verlage 20 000 wisenschaftliche BloggerInnen 1 200 geistes- & sozialwissenschaftl. Journals OPERAS ist eine Forschungsinfra- struktur für offene Wissenschafts praxis in den Sozial- und Geistes wissenschaften in Europa. OPERAS bringt 38 Organisationen aus 15 Ländern zusammen und wird von 9 Core Group-Partnern koordiniert. Die Leitung liegt bei OpenEdition und Huma Num (FR). © infographics: Laetitia Martin Pierre Mounier Associate Director at OpenEdition Coordinator of OPERAS Creative Commons Attribution 4.0 International CC BY 4.0 Die europäische Publikationslandschaft wird von vielen Einzelakteuren ohne Koordination gestaltet. Ein großer Teil der Forschungszeit in den Geistes- und Sozialwissenschaften widmet sich dem Lesen, Annotieren und Schreiben wissenschaftlicher Literatur. OPERAS bringt WissenschaftlerInnen, Bibliotheken und Verlage zusammen, um eine gemeinsame pan-europäische Forschungsinfrastruktur aufzubauen und so die Publikationslandschaft und den wissenschaftlichen Austausch für Forschende zu verbessern. Netherlands Hypothesis Linguistics in Open Access – LingOA OAPEN Quality Open Access Market – QOAM August 2018 United Kingdom KU Research Open Books Publishers Open Library of Humanities – OLH Ubiquity Press UCL Press France Huma Num OpenEdition Core Group Greece National Documentation Centre – EKT/NHRF Croatia University of Zadar University of Zagreb, University Computing Centre – SRCE Poland Institute of Literary Research of the Polish Academy of Sciences – IBL PAN Germany Georg-August-University Göttingen – UGOE Knowledge Unlatched – KU Max Weber Stiftung – MWS Scientific Electronic Library Online – SciELO Luxembourg Luxembourg Centre for Contemporary and Digital History – C²DH Association of European Uni versity Presses – AEUP Belgium University of Liège Italy Associazione Italiana per la promozione della scienza aperta – AISA Conference of Italian University Rectors – CRUI Italian National Research Council – CNR Lexis Compagnia Editoriale Napoli University Federico II Roma Tre University University Ca‘Foscari Venice University of Milan University of Turin – UniTo Portugal NOVA School of Social Sciences and Hu manities University of Coimbra University Institute of Lisbon – ISCTE-IUL Slovenia The Research Center of the Slovenian Academy of Sciences and Arts – ZRC SAZU University of Ljubljana, Faculty of Arts Sweden Stockholm University Library Norway UiT The Arctic University of Norway


Towards a neurocomputational model of the actor-strategy in language comprehension Phillip Alday Matthias Schlesewsky Ina Bornkessel-Schlesewsky Live code at https://bitbucket.org/palday/ginnungagap-code Motivation: The Actor Heuristic Neurophysiological data from typologically diverse languages provide evidence for an actor-based interpretation strategy in language comprehension[1]. The search for an actor depends on a number of prominence scales: person, case, animacy, position, number and deﬁniteness. Actor Space The two arguments in a transitive construction are “pulled” toward or “pushed” away from actorhood by the weight of the individual features. Distinctness between arguments corresponds to distance in the actor space. Argument Prominence prominence distorts the space into attractor basins prominence distorts the space into respulsor hills actorhood follows prominence Weighting Inﬂuences Each prominence scale is subject to a language-speciﬁc weighting. This weighting serves to distort the actor space, increasing or decreasing the relative inﬂuence of speciﬁc prominence features. For example, case is stronger in German than word order, while in English the weight of word order is so extreme that the other scales are largely irrelevant. Aims Here, we sought to quantify the relative weights of the prominence scales and compare this against various proposed metrics in actor space. We used linear mixed models to examine the predictive power of each metric for ﬁxed factors (prominence scales) for human EEG while compensating for subject and item (lexical) variation. Computational Model We implemented an initial quantiﬁcation of the actor heuristic. Weights were estimated with the help of existing research[2]. There are three metrics for measuring distinctness, or diﬀerence in prominence. metric formula description dist P i |NP2i −NP1i| Manhattan distance (feature overlap) signdist P i (NP2i −NP1i) pairwise diﬀerence (signed, unweighted diﬀerence) sdiﬀ ⃗w · ⃗ NP2 −⃗w · ⃗ NP1 scalar diﬀerence of weighted prominences Prominence Hierarchies Feature Hierarchy Person: First = 1 > Other = 0 Case: Nominative = 1 > Accusative = -1 Animacy: Animate = 1 > Inanimate = 0 Position: Early = 1 > Late = 0 Number: Singular = 1 > Plural = 0 Deﬁniteness: Deﬁnite = 1 > Indeﬁnite = 0 Materials and Design 2x2x2x2 design with 60 lexical items; every condition appeared for each lexical item. Word Order Ambiguity NP1-Type NP2-Type Subject ﬁrst × Ambiguous × Noun × Noun Object ﬁrst Unambiguous Pronoun Pronoun 25 Ag/AgCl electrodes @ 250 Hz 37 German native speakers (20 women) 400ms for single words, 500ms for phrases, 100 ms ISI EEG Data NP2 noun NP2 pronoun FCZ CPZ PZ N400 P600 FCZ CPZ PZ N400 P600 0.5 1.0 −4 4 s µV Grand average ERPs triggered at the on- set of NP2 for the ambiguous condition. Blue = subject (actor) initial, Red = object ini- tial; solid = noun, dashed = pronoun for NP1. Model Data dist signdist sdiﬀ N400 P600 Mean EEG (restricted to the left posterior ROI) in each time window as a function of the diﬀerent metrics (centered) and its interaction with ambiguity. The colors indicate the “height”, i.e., a range of (predicted) values of the mean EEG. More color indicates more variation. Metric Performance Likelihood ratio test for models in the N400 time window with NP1 ambiguous. A linear mixed model of the form mean ~ c.(metric) + (1 | item) + (1 | subj), was calculated with lme4[3]. Df AIC logLik Chisq Chi Df Pr(Chisq) dist: 5 197812 -98901.48 signdist: 5 197740 -98865.21 0.00 0 1 sdiﬀ: 5 197596 -98793.06 216.84 0 <2.2e-16*** Discussion All three metrics show some potential; however, sdiff performs signiﬁcantly better than signdist (which performs better than dist). The signedness of signdist allows for conditional prediction — hence the diﬀerent color scale in the ambiguity condition above. The gradience of sdiff allows for much more precise predictions, which is reﬂected in the subtlety present in the respective color scale. Sample


Calibration Strategy of JUNO Junting Huang for the JUNO Collaboration School of Physics and Astronomy, Shanghai Jiao Tong University junting@sjtu.edu.cn JUNO Experiment Liquid Scintillator Non-Linearity Calibration Calibration System liquid scintillator non-linearity: Birks’ law, Cherenkov light gamma calibration sources at different energies treat a gamma event as a collection of e- and e+ using Geant4 build a non-linearity model for e-/e+, fit to calibration data predict the non-linearity for e+ constraint from continuous spectra from cosmogenic B12 and C11 Jiangmen Underground Neutrino Experiment (JUNO) neutrino mass ordering measurement precision measurement of |∆𝑚ଷଵ ଶ|, ∆𝑚ଶଵ ଶand 𝜃ଵଶ calibration goal: for uniformly distributed e+ events better than 1% energy calibration precision better than 3% energy resolution at 1 MeV 17612 20-inch PMTs, 25600 3-inch PMTs, 78 % photocathode coverage Non-Uniformity Calibration 20-inch PMT Calibration Automatic Calibration Unit Cable Loop System Guide Tube Calibration System Remotely Operated Vehicle dark noise, time alignment, gain calibration first hit time vs. charge relative photon detection efficiency 20-inch PMT non-linearity: electronics, waveform reconstruction use 266 nm laser to inject light on a Teflon ball at detector center 3-inch PMTs working in digital mode: fired or non-fired Poisson-zero method: use the number of non-fired 3-inch PMTs to calibrate laser intensity source type energy 137Cs 𝛾 0.662 MeV 54Mn 𝛾 0.835 MeV 60Co 𝛾 1.173 + 1.333 MeV 40K 𝛾 1.461 MeV 68Ge 𝛾 0.511 + 0.511 MeV 241Am-Be n, 𝛾 n + 4.43 MeV (12C*) 241Am-13C n, 𝛾 n + 6.13 MeV (16O*) (𝑛, 𝛾)𝑝 𝛾 2.22 MeV (𝑛, 𝛾) C ଵଶ 𝛾 4.94 MeV or 3.68 + 1.26 MeV detector non-uniformity: PMT acceptance, light attenuation, total internal reflection at the acrylic-water interface calibration sources deployed by the calibration system at different positions in the detector cosmogenic neutrons, about 1 M / week develop reconstruction algorithms that use these calibration data as input to largely remove the detector non-uniformity Positron Energy Resolution Calibration use the e+/e- nonlinearity model to predict resolution curve for e+ further parametrize the resolution curve with 𝜎/𝐸= 𝑎ଶ/𝐸+ 𝑏ଶ+ 𝑐ଶ/𝐸ଶ contributing factors: a: Poisson, b: non-uniformity and Cherenkov, c: mainly dark current and e+ annihilation References: JHEP 03 (2021) 004, F. Zhang PhD thesis (2021), Chin.Phys.C 46 (2022) 12, 123001, arXiv:2405.18008 + low energy sources: 226Rn, 241Am, etc.