Health-related quality of life of people attending screening for diabetic retinopathy within a trial setting CJ Sampson,1† M James,1 D Van Eker,2 D Szmyt,2 SP Harding3 †chris.sampson@nottingham.ac.uk 1University of Nottingham | 2Royal Liverpool University Hospital | 3University of Liverpool Introduction Background • DR associated with lower health-related quality of life (HRQoL) • Economic evaluations tend to base outcomes on visual acuity. Aims • Estimate generic HRQoL for a cross-section of attenders within the UK screening programme • Inform calculation of quality-adjusted life years (QALYs) for model-based economic evaluation. Methods: the sample ▶874 people from 7 screening centres in Liverpool, UK ▶Baseline trial data from the ISDR study ▶Matched screening outcome data R0 No retinopathy R1 Background retinopathy (in at least one eye) Methods: outcome measures ▶Two widely-used generic descriptors of HRQoL. ▶Both can be used to calculate QALYs. ▶Together provide 5 ways to measure HRQoL. EQ-5D-5L Dimensions 5 dimensions reported from 1 (no problems) to 5 (extreme problems) Index score Weighted score based on health state preferences elicited from the UK general public, used to calculate QALYs EQ-VAS A visual analogue scale from 0 (“The worst health you can imagine”) to 100 (“The best health you can imagine”) HUI3 Dimensions 8 dimensions (including ‘vision’) scored from 1 (no problems) to 5 or 6 (severe functional limitations) Index score Multi-attribute utility function, to calculate QALYs Results: full sample ▶840 (96%) fully completed EQ-5D-5L ▶738 (84%) fully completed HUI3 ▶Mean EQ-5D-5L index score was 0.777 ▶Mean HUI3 index score was 0.707 Table: EQ-5D-5L: distribution of responses 1 2 3 4 5 Mobility 52% 15% 17% 15% 0% Self-care 76% 10% 10% 4% 1% Usual activities 57% 15% 15% 10% 3% Pain/discomfort 43% 20% 20% 14% 4% Anxiety/depression 67% 14% 12% 5% 1% Table: HUI3: distribution of responses 1 2 3 4 5 6 Vision 31% 63% 3% 2% 2% 1% Hearing 78% 11% 7% 3% 1% 0% Speech 93% 4% 2% 0% 0% — Ambulation 63% 18% 11% 5% 2% 0% Dexterity 81% 14% 2% 2% 1% 0% Emotion 66% 21% 9% 3% 1% — Cognition 68% 8% 18% 4% 2% 0% Pain 40% 26% 15% 12% 7% — ▶Dimensions with ≥20% of responses are highlighted Results: R1 vs R0 ▶R1 screening outcome associated with lower HRQoL on average than R0 EQ-5D-5L 0.762 vs 0.776 HUI3 0.660 vs 0.713 (p=0.03) EQ-VAS: How do EASDec delegates compare? ▶The left side of the scale shows the distribution in our sample. ▶Place a sticker on the right according to how good or bad your health is TODAY. The best health you can imagine 100 0 The worst health you can imagine Discussion ▶HUI3 recognised as being more sensitive to visual impairment, but may require trade-off with data quality • Lower mean HUI3 index score may reflect inclusion of sensory domains ▶Economic modelling studies that treat R1 and R0 as homogeneous may give biased results ▶We cannot determine whether the difference in HRQoL between R1 and R0 is because of retinopathy level Conclusions ▶DR screening attendees have an impaired HRQoL compared with the general population ▶People with background retinopathy have lower health-related quality of life than people with no retinopathy • Statistically significant difference of 0.053 in mean HUI3 index score ▶HUI3 is associated with poorer completion rates • Greatest missingness on ‘vision’ domain ▶www.isdrproject.co.uk ▶Twitter @ISDRstudy Download this poster DOI: 10.6084/m9.figshare.3443705 This poster presents independent research funded by the NIHR under the Programme Grants for Applied Research programme (RP-PG-1210-12016). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Heath.


Altered Physiological Conditions Lead To Antibiotic Persistence In Vibrio Cholerae. Shridhar Paranjape*, Shashidhar R. Bhabha Atomic Research Centre, Mumbai, India. shridharsonda@gmail.com Introduction The physiological heterogeneity of a bacterial population is a complex phenomenon. The asymmetric cell division and asynchronous metabolic activities result in the population with age gradients. The persister cells are the transiently dormant cells which survive prolonged exposure to bactericidal antibiotics. We hypothesized that the changes in nutrient levels, which are common in the environment, can cause significant changes in tolerance to antibiotics. Here, an attempt has been made to disturb the cell physiology using different strategies to alter the antibiotic persistence. Methods • Antibiotics used: Ciprofloxacin, Ampicillin, Carbinicillin, Kanamycin, Erythromycin, Gentamycin and Chloramphenicol. Data 1. Mulcahy LR, Burns JL, Lory S, Lewis K. 2010 Dec;192(23):6191–9. 2. Harms A, Maisonneuve E, Gerdes K. Science. 2016 Dec 16;354(6318). pii: aaf4268. 3. Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. 2015 May 26;AAC.00864-15. 4. Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S. 2004 Sep 10;305(5690):1622– 5. 5. Fauvart, Maarten & De Groote, Valerie & Michiels, Jan. (2011). 60. 699-709. 10.1099/jmm.0.030932-0. Results 1. The V. cholerae forms persister subpopulations , when challenged with ampicillin and ciprofloxacin. (Fig. 1) 2. The persistence varies with the media type, in the order of decreasing persistence: TSB > LB > M9 > APW. (Table 1) 3. The reduced respiration is key to successful persistence. (Table 2) 4. The V. cholerae was sensitive to inhibition of protein synthesis with no persistence formation. (Table 3) • The present study reveals the complex responses of cell population under antibiotic treatment. • This research could be the beginning of phylogenic clad specific studies of persister cell formation with respect to cell physiology. • The persistence may represent a unique physiological state amongst the various physiological states in a bacterial population. – Single cell based studies may reveal more about the molecular mechanisms underlying persister physiological states. References Fig. 1.Effect of different antibiotics on exponential culture of V. cholerae Table 1. Persistence as a function of media type and nutrient. Table 2. Persistence as a function of respiration Table 3. Persistence as a function of protein synthesis Discussion Fauvart et al.(2011) 0 1 2 3 4 5 6 7 8 9 10 0 2 4 6 8 10 Log CFU ml-1 Time (hours) V. cholerae Ciprofloxacin Kanamycin Ampicillin Persister frequency Media V. Cholerae E. coli Luria Bertani broth 0.1 0.1 Tryptone soya broth 10 0.1 Alkaline peptone water 0.001 NA M9 minimal media 0.01 0.01 Antibiotic V. cholerae E. coli Aerobic An- aerobic ATP - uncoupler Aerobic An- aerobic ATP- uncoupler Ampicillin 1 10 10 0.01 100 100 Ciprofloxacin 0.1 100 10 0.01 10 100 Kanamycin 0 0.01 0 0.1 10 10 Antibiotic V. cholerae E. coli Kanamycin 0 0.1 Chloramphenicol 0 1.0 Erythromycin 0 0.1 Gentamycin 0 0.1


the problem methodology findings on the one hand 1st possible consequence To assess the evaluation process of professional doctorate proposals, three types of analysis were performed: Even though they were not clear before, CAPES had some expectations from proposals. From the evaluation reports of the 105 projects which were not approved, we see examples of such unfulﬁlled expectations: According to CAPES, without previously establishing the criteria and indicators for the accreditation of professional doctorates, they expected: In spite of the lack of pre-established criteria and indicators for the accreditation process, this research showed that CAPES’ evaluation was well conducted and that expectations for the approval of PrD courses are consistent throughout ﬁelds. Expectations Reality on the other hand • Without criteria or indicators for PrD, proposals were: • Too conservative and did not innovate from this “freedom”; • Inspired by academic doctorates (without the required professional nature) or professional master’s (not advanced enough). • Without ground-breaking proposals at hand, the accreditation process could only focus on the viability of the proposed courses, resulting in low approval rates. • The lack of pre-established criteria and indicators did not mean a lack of expectations. Several proposals were weakened because of that. André Brasil a.l.brasil@cwts.leidenuniv.nl Centre for Science and Technology Studies Leiden University, The Netherlands September, 2019 Accreditation of Graduate Courses in Brazil Analysing the Evaluation of the First Proposals of Professional Doctorates in the Country http://bit.ly/2Z6KqJp Approval rates are strikingly different between academic and professional proposals, with fewer accredited courses in the second modality. Proposals Approved Not approved 43.9% 60.0% 77.8% 78.2% Academic Doctorate (PhD) Academic Master’s Professional Doctorate (PrD) Professional Master’s 56,1% 40.0% 22.2% 21.8% Graduate education is responsible for over 80% of S&T research in Brazil Professional Master’s were authorised in 1998 and Doctorates in 2017/2018 135 professional doctorate (PrD) proposals were submitted in the ﬁrst evaluation cycle There are over 6500 graduate courses in the country today Course accreditation is compulsory, conducted by a federal agency (CAPES) No criteria or indicators were stablished before submissions Could an evaluation process without previously defined criteria and indicators work? NOT WITHOUT CONSEQUENCES! http://bit.ly/2M9awpk Get the full paper, this poster, and more at: Regulations and guideline documents related to the accreditation of graduate courses were investigated. Documental The evaluation results of 1404 accreditation proposals were analysed across distinct ﬁelds, levels and modalities. Statistical The reports on the assessment of the 135 professional doctorate proposals were individually analysed in order to identify the existence of coherent criteria and indicators. Qualitative 1 2 3 4 5 6 UNRESTRICTED Proponents would not be limited by pre-established concepts of what a professional doctorate should be. INNOVATION They would innovate, designing ground-breaking graduate programs, which could inspire evaluators. INSPIRATION Evaluation committees would build criteria and indicators based on proposals and previous experience. GUIDELINES The evaluation effort would lead to proper guideline documents to support future submissions. 1 2 3 4 INSTITUTIONAL SUPPORT Expected: projects should include evidence of integration with productive sector. Reality: most projects were successful in that, but some failed to show these partnerships. 73% positive PROPOSAL Expected: projects should have an applied science design at a doctoral level. Reality: most proposals were either too academic or were closer to a master’s level. FACULTY (Profile) Expected: faculty could include experienced professionals from the productive sector. Reality: faculty proﬁle was almost exclusively


Cuscuta campestris Cuscută mare Familia Convolvulaceae, Clasa Magnoliopsida Plantă erbacee anuală, parazită, lipsită de cloroﬁlă, fără frunze, cu tulpini volubile, foarte ramiﬁcate, galbene-portocalii, ce formează prin împletire și răsucire plase laxe ce se întind ca o pânză pe suprafețe de mai mulți metri pătrați. Florile sunt nemirositoare, dispuse câte 10-30 într-un glomerul. Corolă campanulată, cu lobii triunghiulari, acuți. Fructul este capsulă globuloasă, ușor turtită, cu 2-4 semințe brune, ovoidale, cu suprafața neregulată. Foto credit: https://www.invasive.org/search/action.cfm?q=cuscuta+campestris Flori Fruct 1 Semințe


SITool (v1.0) An evaluation tool for large-scale sea ice model simulation Xia Lin, François Massonnet, Thierry Fichefet, and Martin Vancoppenolle 1) Absolute errors at each grid cell (1980-2007) Mean: ->monthly mean over 12 months (Meandiff) Interannual variability/trend: monthly anomalies -> standard deviation (SDdiff)/linear regression (Trenddiff) 2) Average spatially weighted by grid cell areas 3) Scaled by typical errors (absolute difference between two observations) Meandiff = ∑!"# !"#$ ∑&"# &"' ()* !,& ,(#* !,& ×.& ∑&"# &"' .& × #! ∑!"# !"#$ #! (1) SDdiff = ∑&"# &"' $%(')&(')* & )($%('#&('#* & ) ×*& ∑&"# &"' *& (2) Trenddiff = ∑!"# !"$ "#$%&((%!)(%& ! ))"#$%&((#!)(#& ! ) ×,! ∑!"# !"$ ,! (3) 𝑛(months); 𝑖(grid cells); 𝐶/0, 𝐶10/ 𝐶/, 𝐶1(two monthly mean/monthly ice concentration); A (grid cell area); D (days in each month). Sea ice plays a fundamental role in the polar environment, by influencing air–ice and ice–sea exchange, atmospheric and oceanic processes, and climate change. Large inter-model spread exists in the performance of sea ice simulations. Systematic projections and evaluations on sea ice simulations are needed. Want to quantify the bias in sea ice simulations? Want to track performance across different model versions? Try SITool released on the GitHub (open-access): https://github.com/XiaLinUCL/Sea-Ice-Evaluation-Tool A performance metrics and diagnostics tool developed to evaluate the skill of Arctic and Antarctic model reconstructions of sea ice concentration, extent, edge location, drift, thickness, and snow depth. 1 The concept of the SITool 3 Application to CMIP6 OMIP 2 The methods in SITool Find more information on the sea ice edge location, drift, thickness and snow depth in Lin et al. (2021). Xia Lin, François Massonnet, Thierry Fichefet and Martin Vancoppenolle, SITool (v1.0) – a new evaluation tool for large-scale sea ice simulations: application to CMIP6 OMIP. Geosci. Model Dev., 14, 1–24, 2021. SITool provides metrics and diagnostic maps 3.1 Sea ice concentration 3.2 Sea ice extent Any comments/questions? Get in touch! xia.lin@uclouvain.be Metrics: Lower values -> better skill 1) Model errors >> observational uncertainty 2) Improved simulations from OMIP1 (CORE-II) to OMIP2 (JRA55-do) 3) Lower skill on the ice concentration variability Ice extent: total area of grid cells with the ice concentration above 15% -negative ice extent biases in the summer reduced in OMIP2 Model mean ice extent monthly anomalies; -large bias reduced under OMIP2 Diagnostic maps: Reduced negative bias of summer Arctic ice concentration in OMIP2


1) Background • Many people struggle to manage indulgences in our current ‘obesogenic’ environment (Kruger et al. 2004) • Results of our previous qualitative study showed that one of the strategies to reduce intake of tempting foods is to plan meals in advance (Gatzemeier et al. under review) • Planned indulgences increase motivation to continue with goal pursuit (e.g. following a diet to lose weight) (Coelho do Vale et al. 2016) • High restrained eating is associated with lower food intake (Olea López et al. 2016) Jennifer Gatzemeier, Menna Price, Laura Wilkinson, Michelle Lee Department of Psychology, Swansea University, UK. Rigid and flexible restraint moderates a relationship between a future eating prime and food intake Rigid and flexible restraint moderates a relationship between a future eating prime and food intake Coelho do Vale, R., et al. (2016). "The benefits of behaving badly on occasion: Successful regulation by planned hedonic deviations." Journal of Consumer Psychology 26(1): 17-28. Gatzemeier, J., et al. (2018). “Understanding everyday strategies used to manage indulgent food consumption: a mixed-methods design.” Manuscript submitted for publication. Kruger, J., et al. (2004). "Attempting to lose weight: Specific practices among U.S. adults." American Journal of Preventive Medicine 26(5): 402-406. Olea López, A. L. and L. Johnson (2016). "Associations between Restrained Eating and the Size and Frequency of Overall Intake, Meal, Snack and Drink Occasions in the UK Adult National Diet and Nutrition Survey." PLoS One 11(5): e0156320. Van Strien, T., et al. (1986). "The Dutch Eating Behavior Questionnaire (DEBQ) for Assessment of Restrained Emotional, and External Eating Behavior." International Journal of Eating Disorders 5(2): 295-315. Westenhoefer, J., et al. (1999). "Validation of the flexible and rigid control dimensions of dietary restraint." Int J Eat Disord 26(1): 53-64. 3) Methods 3) Methods • Procedure a) Priming: Intervention: writing down near future eating plans Control: writing down near future non-eating plans (e.g. going to the cinema) b) Presentation of taste test: c) Questionnaires: DEBQ (Van Strien, Frijters et al. 1986) Rigid and flexible restraint (Westenhoefer, Stunkard et al. 1999) Question about trait tendency to plan indulgences • Analysis: Moderation analysis with SPSS PROCESS macro • Registered at OSF (https://osf.io/pydvz) 5) Conclusions 5) Conclusions • Flexible and rigid restraint is indeed moderating the association between condition and intake: The intervention condition had a significantly higher consumption compared to the control condition, but only in low rigid and flexible restraint • For low restrained eaters thinking about future eating plans might have enhanced attention to the snacks and therefore increased wanting • High restraint eaters exert a high level of cognitive control to maintain restraint. This might have led to an insensitivity to the priming • Further research is needed to understand the underlying mechanism of the observed interactions and the difference between low and high restrained eaters 2) Research Questions 2) Research Questions • We hypothesis that the trait tendencies to plan indulgences moderate the association between a future eating prime and food intake. Participants with the trait tendencies to plan indulgences consume less after a future eating prime • We are interested if restraint is moderating the relationship between the priming and intake. Contact: Jennifer Gatzemeier jennifer.gatzemeier@swansea.ac.uk Department of Psychology, Swansea University, Singleton Park, Swansea, SA2 8PP, UK Tel: +44 (0) 1792 295279 Swansea Nutrition, Appetite and Cognition group a) Priming b) Taste test c) Questionnaires 1. Minstrels (Mars, UK) 2. Bitsa Wispa (Cadbury, Mondelez, Birmingham, UK) 3. Haribo Star Mix (HARIBO Dunhills, Pontefract, UK) 4. Pringles Original (Wimble Manufacturing Belgium, Mechelen, Belgium) 5. Salted Popcorn (Tesco Stores Ltd., Cheshunt, U


Reactor Neutrino Anomalies and Possible Solutions Yu-Feng Li* Institute of High Energy Physics, Beijing, China *corresponding author: liyufeng@ihep.ac.cn Reactor neutrinos (electron antineutrinos) are produced from beta decays of the neutron-rich fission products, and are detected via the inverse beta decay (IBD) process. Reactor experiments have shown anomalous results for both IBD rate (left plot) and spectrum (right plot) measurements Reactor rate anomaly: measured IBD yields are smaller than model predictions by around 6%. Reactor spectrum anomaly: there is a bump at around 5 MeV when comparing the measured and predicted spectra. How to solve these reactor anomalies is an intensively discussed topic in nuclear and particle physics community. 1. Reactor neutrino anomalies 3. Ab initial method Using the reactor rates data and fuel evolution data: 2. Data-driven method Reactor rates tend to favor equal suppression of the 235U and 239Pu fluxes (oscillation), while (DYB & RENO) fuel evolution data favor the suppression of 235U. Regarding all hybrid hypotheses: a) a deficit for the 235U flux is always obtained; b) oscillation-including hypothesis is favored over the oscillation-excluding one: moderately at 1-2σ 5. Conversion method Giunti et al., JHEP 10 (2017) 143 4. Beta decay at KATRIN 6. Conclusion Reactor rate/spectrum anomalies are interesting topics in particle and nuclear physics, and awaiting satisfactory solutions. Data-driven method always favors a suppression of the 235U flux, while KATRIN can provide independent tests. Both the ab initial and conversion calculations need to be improved in many aspects (database, fission yield and single spectrum, etc.). Accurate reactor rate and spectrum predictions are important for future reactor experiments (i.e., JUNO). Giunti et al., Phys. Rev.D 99 (2019) 073005 Ab initial model for the reactor neutrino flux: summation of each beta decay branches using the nuclear database for the fission and decay information Possible problems: the nuclear database (e.g., pandemonium effect), fission yield, single beta decay spectrum, etc. We discuss the effects of the single beta decay spectrum by using a fully numerical calculation of lepton wave functions, compared to previous ones using the famous Fermi function. Fang, et al., arXiv: 2001.01689 ENDF VIII.0, for fission yield data, and ENSDF for the decay data. 2% and 4% deviations for the neutrino and electron spectra. Beta decay is a model-independent way to probe the absolute neutrino masses. KATRIN published its first data in 2019, with a limit on the effective neutrino mass as mν< 1.1 eV (95% C.L.). We test the reactor rate anomaly using the beta decay data at KATRIN by assuming the 3+1 active-sterile mixing. KATRIN improves the exclusion of the large-Δm2 41 solution of the Huber-Muller reactor rate anomaly. RSR: the reactor spectra ratio data test a large part of the small-Δm2 41 region. Tritium: KATRIN + Mainz + Troitsk RSR and Tritium limits are complementary, and rule out most of the parameter space. Giunti et al., JHEP 05 (2020) 061 Conversion model for the reactor neutrino flux: using dozens of virtual beta decay branches to fit the aggregate electron spectra of 235U, 239Pu, and 241Pu at ILL. We propose a new realization of the conversion calculation by including the contribution of forbidden decay branches. Using data of ILL U235 beta spectrum Li, et. al., Phys. Rev. D 100 (2019), 053005 7. Reference [1] G. Mention et al., Phys. Rev. D 83 (2011) 073006. [2] T.A. Mueller et al., Phys. Rev. C 832011) 054615. [3] P. Huber, Phys. Rev. C 84 (2011) 024617. [4] KATRIN, Phys. Rev. Lett. 123 (2019) 221802. [5] C. Giunti et al., Phys. Rev. D 99 (2019) 073005. [6] Y.F. Li, D. Zhang, Phys. Rev. D 100 (2019) 053005. [7] D.L. Fang et al., arXiv: 2001.01689. [8] C. Giunti et al., JHEP 05 (2020) 061.


LATEX TikZposter ANALYTICAL HALO MODEL OF GALACTIC CONFORMITY Isha Pahwa and Aseem Paranjape Inter-University Centre for Astronomy and Astrophysics, Pune University Campus-Ganeshkhind, Pune - 411007 ipahwa@iucaa.in ANALYTICAL HALO MODEL OF GALACTIC CONFORMITY Isha Pahwa and Aseem Paranjape Inter-University Centre for Astronomy and Astrophysics, Pune University Campus-Ganeshkhind, Pune - 411007 ipahwa@iucaa.in Galactic Conformity is the observation that satellite galaxies in groups whose central galaxy is quenched (or red) are preferentially quenched, even when the groups are restricted to reside in dark matter halos of the same mass. We develop a model to include the effects of ‘Galactic conformity’ within halo occupation distribution (HOD) framework. This effect has been modelled via the correlation of galaxy colors in a group with the concentration of the common parent dark matter halo. Standard HOD Framework • fcen(> L|m) - The fraction of m-halos (i.e., halos with masses in the range (m, m + dm)) that have a central galaxy brighter than the luminosity threshold L. • Nsat(> L|m) - The number of satellites brighter than L in each m-halo with a central brighter than L (assumed to be Poisson distributed with mean). fcen(> L|m) = 1 2  1 + erf log(m/Mmin) σlog m  , Nsat(> L|m) = m −M0 M1 α , [Zehavi et al 2011] with {Mmin, σlog m, α, M1, M0} being functions of the threshold L. We deﬁne the following quantities that are ﬁxed by the HOD: Nsat(> L|m) ≡fcen(> L|m)¯Nsat(> L|m) ; fcen(L|m) ≡−∂fcen(> L|m)/∂L , Nsat(Lm) ≡−∂Nsat(> L|m)/∂L ; ¯Nsat(L|m) ≡Nsat(L|m)/fcen(> L|m) . Color-selcted HOD •Given p(red|Mr) = 0.423 −0.175 (Mr + 19.5) and [Paranjape et al 2015] p(red|sat, Mr) = 1.0 −0.33  1 + tanh Mr+20.25 2.1  , one can calculate p(red|cen) from equation p(red|L) = p(red|cen, L) ¯p(cen|L) + p(red|sat, L) ¯p(sat|L) , where ¯p(sat|L) = R dm n(m) Nsat(L|m) R dm n(m) [fcen(L|m) + Nsat(L|m)] • The HOD split by galaxy colour - frcen(L|m) ≡p(red|cen, L)fcen(L|m) , Nrsat(L|m) ≡p(red|sat, L)Nsat(L|m) , ¯Nrsat(L|m) ≡Nrsat(L|m)/fcen(> L|m) = p(red|sat, L)¯Nsat(L|m) . frcen(L|m)dL is the differential fraction of m-halos with red L-centrals and ¯Nrsat(L|m)dL is the mean differential number of red L-satellites in m-halos with centrals (of any colour) brighter than L. Red fractions as a function of luminosity −22.0 −21.5 −21.0 −20.5 −20.0 −19.5 −19.0 Mr 0.0 0.2 0.4 0.6 0.8 1.0 red fraction satellites all centrals psat HOD with galactic conformity • We introduce conformity between the central and satellite colors in a group using the model of Paranjape et al 2015 which correlates the red fraction of a given galaxy type with the parent halo concentration, i.e., a concentration-dependence of the red fraction of satel- lites/centrals at ﬁxed luminosity and halo mass by making galaxies in high (low) concentration halos preferentially red (blue). • Given the fact that distribution of halo concentration c at ﬁxed halo mass is approximately Lognormal with mean ¯c(m) ≡e⟨ln c|m ⟩and logarithmic scatter σln c, we deﬁne s ≡ln(c/¯c)/σln c . The distribution of s is approximately a standard Gaussian (zero mean and unit variance), independent of halo mass. The conditional red fraction now depends on the parent halo concentration and is given as p(red|sat/cen, s) = (1 −ρ) p(red|sat/cen) + ρ Θ(s −sr,sat/cen) , where sr,sat/cen gives the dividing line between high and low concentrations in each case as sr,sat/cen = √ 2 erfc−1 [2 p(red|sat/cen)] . • “group quenching efﬁciency", ρ ∈[0, 1]. • The color selected HOD with conformity - frcen(L|m, s) ≡p(red|cen, s)fcen(L|m) , Nrsat(L|m, s) ≡p(red|sat, s)Nsat(L|m) and ¯Nrsat(L|m, s) ≡Nrsat(L|m, s)/fcen(> L|m) = p(red|sat, s)¯Nsat(L|m) . 1-halo conformity • Difference in the red fractions of satellites with red and blue centrals of similar halo mass represented by red and blue colors. −22.0 −21.5 −21.0 −20.5 −20.0 −19.5 −19.0 Mr 0.0 0.2 0.4 0.6 0.8 1.0 satellite red fraction ½ =0:01 ½ =0:65 ½ =0:90 Correlation funct


A Key Actor in EMI METU English Proficiency Exam: Design, Implementation & Validation Aim The School of Foreign Languages (SFL) initiated a Program Evaluation and Renewal study to investigate the effectiveness of the English Language education curricula at its two departments based on a large scale needs analysis of all relevant stakeholders which involved the evaluation and validation of METU English Proficiency Exam, integral to EMI at METU. Design This research was designed as a mixed methods study. Our approach towards the qualitative / quantitative dilemma was pragmatic. Pragmatism views these two methods as compatible (Howe, 1988, in Teddlie & Tashakkori, 2009), and therefore finds it productive to combine these methods to study phenomena especially in social sciences. Hence, the pragmatic paradigm was the framework of this study. Needs Analysis Data Analysis English Proficiency Examination EPE Revisited- OPERATIONS Design Identifying Target Language Use tasks, task characteristics, theoretical constructs Operationalization Developing test task specifications & test blueprint Administration Alpha & Beta testing Piloting Field-testing Final revision First official version of new EPE Results: Communicative Needs of EMI students Benchmarking, Piloting & External Validity To validate EPE, an experimental pretest-posttest design (N=211) was used to compare EPE scores with an international standardized test, TOEFL IBT, a gatekeeper in many EMI universities. There was a significant positive correlation between EPE and the pretest (r = 0,89, n = 102, p = 0.070); between the two versions of the TOEFL IBT (r = 0,89, n = 102, p = 0.00); and between EPE and the posttest (r = 0.85, n = 115, p = 0.044). EPE cut scores were based on this study. Listening: Field, 2012 Reading: Urqhart & Weir, !998; Khalifa & Weir, 2009 Writing: Shaw & Weir, 2008 Reliability & Internal Validity Predictive Validity & Stakeholder Perception Stakeholders Qualitative / Quantitative Instr. 2612 DBE Ss Surveys / Focus- group interviews 2205 MLD Ss Surveys / Focus- group interviews 133 SFL Instructors Surveys / Interviews 66 Faculty Members Interviews 40 Graduates in 19 Firms Interviews 14 Employers in 12 Firms Interviews Document Analysis of student essays, exams, lab reports from all faculties Communicative Activity Required Skill Listening -listening in-class -assigned listening Very deep attention understanding instructions Medium to deep attention following lectures /discussions Reading -background reading -intensive reading search reading reading longer texts careful reading understanding instructions analytical/critical reading interpreting visuals Writing -writing in -class -assigned writing note-taking writing responses to exam projects, reports, papers fluency & coherence Speaking -spontaneous speech -planned speech communicating with instructors asking & answering Q’s delivering presentations fluency in speech Grammar & Vocabulary basic structures - wide range academic lexis • For quantitative data, descriptive and inferential statistics were employed. Depending on the results of tests of normality, either ANOVA/ t-Test or Kruskall- Wallis and Mann-Whitney U tests were used. • As for qualitative data, the recordings of interviews were analyzed by MaxQDA 11. Miles and Hubermann Qualitative Data Analysis Framework was used (1994). Theoretical Framework of Test Design Sociocognitive Framework, Weir, 2005 The relationship between, TOEFL Pre-and Po EPEsttests Reliability: Cronbach’s alpha, which measures the internal consistency of a group of items was found to be (α= .81). This alpha coefficient is high (≥70 ) in terms of testing. Item Discrimination: The Rpbi mean for the MC items was found to be Rpbi .33, meaning that the exam discriminated well between higher and lower proficiency levels. Items with Rpbi in the .30 - .49 range are considered strong discriminators. Item difficulty: P values for the scored items show a desired distribution of the P (.4


Figura 1. Intervalos para la Varianza aditiva estimada, para los grupos de años. Figura 2. Intervalos para la Heredabilidad estimada, para los grupos de años. 0.0021 0.0060 0.0054 0.0113 0.0000 0.0050 0.0100 0.0150 0 1 2 3 Grupos Va Ln 0.09 0.25 0.16 0.31 0.00 0.10 0.20 0.30 0.40 0 1 2 3 Grupos Heredabilidad Ln Figura 3. Intervalos para la Varianza aditiva estimada, para los grupos de años. Datos en Ln. Figura 4. Intervalos para la Heredabilidad estimada, para los grupos de años. Datos en Ln. Cva Cva Ln Grupo 1 0.055 0.023 Grupo 2 0.080 0.036 Cuadro 1. Coeficientes de variación aditivos para cada uno de los grupos de años, con datos originales y en LN. Evolución de la Variabilidad Genética para peso a edad comercial en una población seleccionada de camarón blanco del Pacífico [Penaeus (Litopenaeus) vannamei]. Cala N¹*, Montaldo HH¹, Castillo-Juárez H², Campos-Montes GR², Ruiz-López FJ³. Universidad Nacional Autónoma de México¹, Universidad Autónoma Metropolitana- Xochimilco², Centro Nacional de Investigación en Fisiología y Mejoramiento Animal, INIFAP³. necamo4@comunidad.unam.mx Introducción En una población de tamaño efectivo limitado bajo selección, se pueden producir cambios en las varianzas genéticas y ambientales a través de las generaciones, que pueden reflejarse en cambios en la variabilidad genética. Estos cambios manifiestan una disminución en la variación genética a través de las generaciones para la población en selección. Objetivo Estimar cambios los componentes de variabilidad genética y ambiental para P130 en 8 generaciones de una población núcleo de camarón blanco del Pacífico bajo selección. Material y Métodos Se usaron datos de ocho generaciones (2003-2010) de una población Mexicana de camarón blanco del Pacifico seleccionada para peso a los 130 días, con su respectivo pedigrí. Se analizaron 123,561 registros, procedentes de la progenie de 1043 madres y 746 padres. La estructura es por familias, provenientes de apareamientos de un macho con dos hembras mediante inseminación artificial. Se utilizó un modelo lineal mixto en ASReml. Los efectos fijos fueron año-estanque-sexo y los efectos lineal y cuadrático de la edad a la cosecha como covariables. Los efectos aleatorios, el efecto genético aditivo, el efecto de ambiente común de familia de hermanos y el error. En el modelo se consideraron varianzas heterogéneas por generación (año). Resultados y Discusión Los parámetros usados para evaluar los cambios fueron la heredabilidad “ ( )”, la varianza aditiva “ ” y el coeficiente de variación aditivo “ (√ ̂)”. Se estimaron las tendencias con las ecuaciones de regresión lineal y polinomiales de segundo y tercer orden para , y . Los resultados para la regresión lineal muestran una tendencia negativa P < 0.05, sin embargo el coeficiente de variación señala una tendencia positiva P < 0.05, lo que es contradictorio. También se realizaron análisis similares usando el logaritmo natural de P130. Posteriormente se dividió la base en dos grupos de años, uno del 2003 al 2006 y otro del 2007 al 2010, intentando buscar una tendencia en los estimados, se analizó la , y graficando los intervalos para , (Figuras 1, 2), de igual forma se analizaron los datos transformados a logaritmo natural (Figuras 3, 4). Los coeficientes de variación calculados para cada grupo se presentan en el cuadro 1. Conclusión Los resultados obtenidos de los análisis para y usando los datos originales y transformados a logaritmo natural de P130 no indican cambios significativos a través del tiempo para ninguno de los dos parámetros, lo que coincide con los resultados de y sugiere que hay efectos importantes de escala que deben tomarse en cuenta para analizar este tipo de datos , por lo cual no podemos afirmar estadísticamente que para los datos utilizados en éste estudio haya habido una pérdida significativa de la variabilidad genética aditiva en respuesta al proceso de selección en el transcurso de los años posteriores al 2005. Todavía otra posibilidad es qu


Data from OSM has been automatically categorised in several accessibility classes, in accordance with the national and regional legislation. Two different types of maps have been produced: current status, with footways, crossings, kerbs and obstacles represented, and project status, with modiﬁed elements included in the plan. 1000 kerbs mapped 400 crossings mapped 31% inaccessible kerbs 10000 images uploaded in Mapillary 60000 €/km costs estimated 155 buildings assessed 12 recurring situations 37 standard intervention typologies 10 meetings were organised in 10 different locations, corresponding to the 10 sub-departments of the city. The aim was to present the project and collaboratively decide the areas/paths to be mapped and where to assess accessibility during the following mappings events. 10 mapping events were organised with citizens and local organizations both as demonstration and training for the use of mapping tools (FieldPapers, Mapillary, OSMAnd), and for collection of local expertise on accessibility. Then expert mappers ﬁnalized the collection in information and the upload on OpenStreetMap. Various open tools have been used: FieldPapers during mapping events; OsmAnd during technical mapping; Mapillary for collection of street-level pictures; JOSM for editing OpenStreetMap data; QGIS for the production of ﬁnal cartographic maps of the ofﬁcial plan. PARTICIPATORY MEETINGS MAPPING The "PEBA - Piano per l'Eliminazione delle Barriere architettoniche" (Plan for the elimination of architectural barriers) is a legislative tool aiming at ensuring full accessibility of urban paths, spaces and buildings for all the people. The local administration of Padua ﬁnanced the creation of the PEBA of the city, with the brand "Padova + Accessibile" (Padua more accessible). More information at http://www.comune.padova.it/ peba. The two main criteria for the development of the plan have been a wide participatory vision and the use of open geospatial tools for analysis. OpenStreetMap has been selected as the core tool for mapping accessibility. elements. 10 meetings with citizens and associations 66 invited associations 40 km of footways/paths mapped 137 disabled designated parking spaces 370 geolocated +reports 229 obstacles observed 1.5 km of non-accessible sidewalks 17 km of sidewalks with limited accessibility OUTPUT MAPS CREDITS The local administration of Padua (Comune di Padova) funded the realization of the PEBA, including participatory meetings and mapping events and activities (contact person arch. Alberto Marescotti). Wikimedia Italia provided free patronage for mapping events; various Wikimedia Italia volunteers contributed to the mapping and editing activities. Image “Padova+accessibile” by arch. Alberto Marescotti. Font OpenDyslexic ®. Background image ©OpenStreetMap contributors. Project manager Elena De Toni. The PEBA (Plan for the elimination of architectural barriers) of the city of Padua has been the ﬁrst example in Italy of the direct use of OpenStreetMap as main tool to collect information and derive decisions for the characterization of accessibility of public areas and paths. In the area of Padua, data in OSM have been improved in relation to information on accessibility of public areas and path, especially for disabled people; in addition to this, through the involvement of citizens and local organizations, the use of open source technology and the revision and application of a tagging scheme for OpenStreetMap, accessibility information will be easily updated and extended in the future. CONCLUSIONS TAGGING SCHEME PEBA IN NUMBERS PEBA During the activities of the PEBA, a short guide on how to map parkings for people with disabilities was produced and then shared and promoted to a few associations working on disabilities. In 4 months the number of these parking spaces increased from 0 to ~140, allowing the production of a dynamic map that is being continuosly updated. PARKING SPACES This work is available at http:/


Are Physicians Ready to Take up Leadership Roles in Planetary Health? Suraj Bhattarai1,2; Omary Chillo3; Biljana Gjoneska4; Dipendra Khatiwada5; Jaifred Christian F. Lopez6; Atiya Mosam7; Juan Carlos Núñez Enríquez8; Duha Shellah9; Nora Grasselli10 1Global Health Research & Medical Interventions for Development, Nepal; 2London School of Hygiene & Tropical Medicine, UK; 3Muhimbili University of Health and Allied Sciences, Tanzania; 4Macedonian Academy of Sciences and Arts, North Macedonia; 5College of Medical Sciences, Nepal; 6Duke University, USA; 7Mayibuye Health and University of the Witwatersrand, South Africa; 8UMAE Hospital de Pediatría CMN Siglo XXI, IMSS, Mexico; 9Palestine Academy for Science & Technology, Palestine; 10European School of Management and Technology, Germany. INTRODUCTION • Physicians’ role is primarily thought to provide patient care. • They also contribute to improve healthcare systems & health indicators.a • However, their role in planetary health has not been established nor defined yet. • Young Physician Leaders Programme (YPL) is a flagship training programme of the InterAcademy Partnership (IAP) – the parent academy of 149 national science academies worldwide.b • IAP has a mission to “foster the next generation of research and science policy leaders” by strengthening critical capacities for leadership.b REFERENCES aInstitute of Medicine (US) Division of Health Sciences Policy. Medical Education and Societal Needs: A Planning Report for the Health Professions. National Academies Press (US); 1983. Chapter 4, The Physicians’ Role in a Changing Health Care System. bThe InterAcademy Partnership. www.interacademies.org cMyers SS, Potter T, Wagner J and Xie M. Clinicians for Planetary Health. One Earth; 2022. dMoser AM, Stigler FL and Haditsch B. Physicians’ responsibility for planetary health. The Lancet Planetary Health; 2017. METHODS • A semi-structured questionnaire was developed based on literature review and distributed electronically to the 10-year YPL cohorts (2011- 2022), with assistance from the IAP Secretariat. • The 8-member YPL Alumni Steering Committee coordinated the study, in collaboration with the ESMT. • EMST ethics committee provided ethical clearance to the survey. • Descriptive statistics was used to analyse the data. RESULTS • Out of 235 physicians approached, 77 (33%) completed the survey. • 51% were female. Majority (73%) represented LMICs. • 52% of the respondents were engaged in clinical practice, 60% in research, 29% in strategic and policymaking roles, 14% in bureaucracy. CONCLUSIONS • Physicians are extending their work area beyond curative medicine, embracing upstream approaches to impact population health. • Therefore, it is important to acknowledge physicians as key stakeholders of planetary health and engage them in global initiatives. OBJECTIVE To explore the engagement of YPL alumni in health sector in the context of emerging global discourse on planetary health. Young Physician Leaders (YPL) at a glance • YPL programme is running since 2011. • It has 21 new members and 231 Alumni across 5 continents. • Each year, national academies send their nominations to IAP and its expert medical panel selects the new cohort (~20 members). • World Health Summit, M8 Alliance and European School of Management and Technology (ESMT) are main programme partners, among others. • While 30% of the respondents worked from central or federal level, the majority (58%) worked from local level (district or community facilities). DISCUSSION • Physicians’ community represent highly educated and respected professionals and apt science communicators, so they could be the most suitable messengers/ debaters/ negotiators for planetary health.c • Next generation physicians should be educated to recognize planetary health as the foundation for any efforts to improve human health.d May 27-29, 2024 Geneva, Switzerland Contact: Dr. Suraj BHATTARAI Director and Investigator GLOHMED, Nepal E: surajbhattarai.m


X-ARAPUCA as photon detection system of SBND Ana Machado for SBND Collaboration NEUTRINO 2024 June 16-22, 2024 – Milan, Italy Three LArTPC detector to study short range neutrino oscillation • Neutrino-argon interactions at GeV energy scale. Millions of nµ and thousands of ne from two neutrino beams • Verify the “low-energy excess” anomaly Investigate the excess of ne observed by MiniBooNE experiments • Search for sterile neutrino Discover or exclusion of 1 eV-scale sterile neutrino mass region • Beyond Standard Model Physics 192 X-ARAPUCA 176 ARARA readout SensL - 3x3m2 SiPM. (C-series 30050-A1) 88 VUV OPTO 400nm PTP coating EJ286 88 Visible OPTO 450nm EJ280 16 APSAIA readout Hamamatsu - 6x6m2 SiPM. (S13360-6050 VE & HS) 8 VUV OPTO 400nm PTP coating Glass to Power 8 Visible OPTO 450nm Glass to Power FILTER (400nm cutoff) PTP (emission 350nm) SiPM WLS plate LAr scintillation light FILTER (450nm cutoff) SiPM WLS plate Visible light Photon Detection System Active elements: on the PD-BOX, behind the anode. • 120 8” Hamamatsu Cryogenic PMT’s (96 TPB coated + 24 uncoated) • 192 X-ARAPUCA (96 VIS + 96 VUV) Passive element: at the cathode. Wavelength-Shifting Reflective plates (TPB coated) 64 double-sided Short Baseline Near Detector TPC Cathode Plane at -100 kV divides the detector into 2 drift volumes. Drift distance is 2 m, drift time is 1.28ms Anode Plane on either side. Each consists of 3 planes of wires with 3 mm spacing and different angle per plane. Total of 11,260 wires Cold (89K) Electronics to pre-amplify and digitize signals Field Cage that wraps around the 2 LArTPCs to step down the voltage & ensure uniform electric field of 500 V/cm. Cosmic Ray Tagger (CRT) Scintillator strips with SiPM readout 142x32 channels X-TDB X-ASB All PCB boards were tested in cryogenic temperature 60 SiPMs was tested - 48 6050-VE (VBr = +53V @RT) - 12 6050-HS (VBr = +38V @RT) A total of 777 X-TDBs were tested at the LN2 temperatures and able to see light. 704 were required. Only 1 “bad” board was identified Digitized signal from the HS test – APSAIA – ARAPUCA POWER SUPPLY AND INPUT AMPLIFIER – ARARA – ARAPUCA ANALOG READOUT AMPLIFIER Readout Electronics The APSAIA will power the SiPMs and amplify their 32 output signals. It is hosted in the outer flange of SBND. Each board has 8 channels with input connectors. The power supplies are designed to meet the SiPMs' requirements, and the amplifiers process the SiPMs' output signals. Each channel has an MCX output connector. The power supply and serial port connector use a standard DB15 connector. The supply voltage for the SiPMs is remotely adjustable up to 60 V with a resolution of less than 100mV. The power supplies and amplifiers are controlled by a microcontroller connected to an RS232C port. RJ45 à DB37, cold side view The preamplifier board conditions and biases the signal between the X-ARAPUCA light collection hardware and the signal capture hardware The bias voltage must be programmed remotely using an RS232c. The power supply is available via a cable with a DSUB9 connector. The 352 signals for flange are inputs for ARARA board. Into the ARARA board the signals are ganged by 4. RAVANA board convert signals from the ARARA to the CAEN 1740 digitizers Single-channel prototype of the pre-amplifier by AGE scientific These preamp modules are: - Double width 6U VME cards in custom crate. - Powered by externally provided 8V DC - 64 input channels for 16 output channels - Compliant with FNAL Electrical Design Standards for Electronics The amplifier characteristics are as follows: - Minimum gain of 20, adjustable via microcontroller if other gain values are needed. - Sufficient bandwidth for processing 30 ns rise-time signals, DC-coupled. - Output impedance of 50 Ω. ASSEMBLY & INSTALLATION 1o step: The assembly of the mechanical and optical parts (dichroic filters and light guide) was done at Unicamp 2 o step : The PCB board installation in each X- ARAPUCA was carried out at Fermilab. Finally, 4 VUV X-A


Comparison of fatty acid composition in grass-fed and grain-fed horse meat Aidyn Igenbayev, Shyngys Amirkhanov, Muhtarbek Kakimov, Alida Kanabekova S. Seifullin Kazakh Agrotechnical University, Astana, Kazakhstan Reference: Igenbayev, A., Amirkhanov, S., Ospankulova, G., Kardenov, S., Baytukenova, S., & Ali Shariati, M. (2022). Determination of the fatty acid composition and fatty acids trans-isomers in the horse, stall horse, mutton, beef and pork meat. Potravinarstvo Slovak Journal of Food Sciences, 16, 800–809. https://doi.org/10.5219/1799 The objective of this research was to analyze the fatty acid composition of horse meat. The study involved the selection of two distinct groups of horses: 1) horses that were raised and fed in a pasture; 2) horses that were kept in stalls. For the analysis, pasture horse meat (Kazakh horse breed), and stall horse meat (Kazakh horse breed) were purchased from meat markets and supermarkets in Astana, Kazakhstan. Samples were obtained from four diﬀerent carcass muscles (back muscles, thigh muscles, rib muscles, neck muscles) of each animal, an average of 500 grams of sample. The samples obtained were stored at a temperature of - 18 ºC. Horse meat for pasture and stall keeping was supplied from farms engaged in horse breeding in an appropriate way of feeding. This analysis compares the fatty acid composition of grass-fed and grain-fed horse meat, speciﬁcally in the loin cut. The data shows that grain-fed horse meat has a higher percentage of saturated fatty acids (SFA) compared to grass-fed horse meat, with the content being 40.32% and 37.43% respectively. Conversely, grass-fed horse meat has a higher percentage of monounsaturated fatty acids (MUFA) compared to grain-fed horse meat, with the content being 48.12% and 40.36% r e s p e c t i v e l y. T h e p e r c e n t a g e o f polyunsaturated fatty acids (PUFA) is also higher in grain-fed horse meat compared to grass-fed horse meat, with the content being 19.31% and 14.44% respectively. Table 1. Fatty acid content in muscle lipid fraction of grass fed horse meat, % of total fatty acids Table 2. The fatty acid content in the muscle lipid fraction of grain-fed horse meat, % of total fatty acids This study reports the levels of trans fatty acids (TFAs) in diﬀerent cuts of grass-fed horsemeat, revealing that the TFA content varies across cuts with the highest level in loin (1.85%) and the lowest in round (1.66%). The levels of TFAs in rib (1.68%) and neck (1.70%) are similar to each other and fall in between the levels observed in loin and round. This study presents data on the levels of trans fatty acids (TFAs) in various cuts of grain-fed horsemeat, revealing that the TFA content is markedly higher in round (5.54%) and neck (5.52%) than in loin (2.75%) and rib (3.56%). These ﬁndings suggest that the TFA content in horsemeat can be inﬂuenced by the type of feed given to the animals. As high intake of TFAs has been linked to increased risk of cardiovascular disease, these results provide important information for assessing the potential health risks associated with the consumption of grain-fed horsemeat. This comparison suggests that the type of diet fed to horses can have a signiﬁcant impact on the fatty acid composition of their meat. The higher content of SFAs in grain-fed horse meat may increase the risk of cardiovascular disease, while the higher content of MUFAs in grass-fed horse meat may have potential health beneﬁts. The higher content of PUFAs in grain-fed horse meat may also be beneﬁcial, as PUFAs are essential fatty acids that have been linked to a reduced risk of cardiovascular disease. However, the speciﬁc types of PUFAs present in grain-fed horse meat should be taken into consideration, as some types of PUFAs may be more beneﬁcial than others. Further studies are needed to explore the health implications of consuming grass-fed vs. grain- This research is funded by the Ministry of Agriculture of the Republic of Kazakhstan (BR1076499


Analysis 大質量星 Telescope Resolution Reference !"CO(2 −1) ALMA 1.12” (53 pc) Leroy et al. (2021) Hα VLT 0.92” (44 pc) Emsellem et al. (2022) Giant molecular clouds and their Type classification in M74 Fumika Demachi 1, Yasuo Fukui 1, Kengo Tachihara 1, Rin Yamada 1, Kazuki Tokuda 2,3, Shinji Fujita 4, Masato Kobayashi 5 Kazuyuki Muraoka 6, Ayu Konishi 6, Tsuge Kisetsu 4, Toshikazu Onishi 6, Akiko Kawamura 3 (Nagoya university 1, Kyushu university 2, National Astronomical Observatory of Japan 3, University of Tokyo 4, University of Cologne5, Osaka Metropolitan university 6 ) 1. 3. Need to expand samples to establish a general picture of GMC evolution. [ The goal of this study ] Establish the method of Type classification based on 𝐿!" Suitable for resolving GMCs without contamination in a line of sight Distance: 9.7 Mpc (Anand et al. 2021) Inclination: 8.9° (Lang et al. 2020) 𝑀()*+ = 10,-./0𝑀⊙, 𝑀23 = 104.5-𝑀⊙ (Leroy et al. 2021) M74 Giant molecular clouds (GMCs) are the main star formation sites and their evolutions are important to understand galaxy evolution. In this poster, we discuss GMC evolution in nearby spiral galaxy M74 by using spatially resolved GMC samples. We classified GMCs into 3 types based on Hα luminosity (𝐿67) of HII regions with GMCs, and Type I (without star formation) are 58, Type II (with 𝐿67 < 10/5.8 erg s9,) are 202, and Type III (𝐿67 > 10/5.8 erg s9,) are 172, then obtained these results, (1) the young star clusters clearly associated with Type II and III GMCs, and 𝐿67 and cluster mass show tight correlation for Type III (2) massive Type I GMCs show the sign of embedded star formation and Type II GMCs are affected by extinction more than Type III, and (3) Type III are the most virialized state. For these results, we interpreted GMC Type classification as GMC evolutionary sequence from Type I to III with active star formation. In this study, Type classification are applied in grand design spiral galaxy out of the local group for the first time. 1. Identify GMC by PYCPROPS*1 and HII region by Astrodendro*2. 2. Determine the association between GMC and HII region if their boundaries are overlapped, and classify GMCs based on 𝐿2:. 3. Compare Type GMCs with clusters*3 obtained by HST and 21 µm emissions*4 obtained by JWST to check consistency with results of LMC and the effects of Hα extinction, respectively. → Classify GMCs based on Hα luminosity (𝐿67) 10/5.8 erg s9, of associated HII regions because Hα is more uniformly surveyed Results 4. We identified 58 Type I, 202 Type II, 172 Type III (Fig.1). The median of GMC mass and radius increase Type I<II<III. Type III GMCs are in the most virialized states (Fig.2). 1-4 Myr clusters are located closer to GMCs than typical GMCs separation (Fig. 3). GMC evolution 5. Fig.2 → Type III GMCs are most gravitationally relaxed. Conclusions 6Type classification base on 𝐿2: is useful method to distinguish different evolutionary phases as tested in M74, out of the Local group, for the first time. Extend into other galaxies to validate the universality and for the future work. Assume GMCs evolve steadily and the timescale of Type III is 4 Myr based on associated cluster age. Estimate the timescale of Type I and II by the ratio with Type III statistically → Type I: 1Myr, Type II: 5Myr, Type III: 4Myr [Problem] GMC [Type I ] No star formation [Type II ] With HII region (𝐿!" < 10#$.&) [Type III ] With HII region (𝐿!" > 10#$.&) HII region *1: Rosolowsky et al. 2021, *2: Rosolowsky et al. 2008, *3: Adamo et al. 2017, *4: Lee et al. 2023 Fig.3) Histogram of separation between nearest GMCs and clusters. The orange line indicates typical GMC-GMC separation. Fig.4) Scatter plot between total cluster mass and Hα luminosity associated common GMCs. The size of marker indicate the number of clusters with each GMC. The cluster mass increase with 𝐿2: especially for Type III (Fig. 4). 35% of Type I and more than 80% of Type II and III are associated with 21 µm emission. Correct Hα extinct lu


Ergebnisse • Diskriminanzfähigkeit zw. Bildern η2T1 = .28, η2T2 = .33 • Inter-Rater-Reliabilität ICCT1 = .81, ICCT2 = .84 • Test-Retest-Reliabilität r = .93 • Hauptkomponentenanalyse 8-Faktorenlösung • Tucker-Korrelationskoeffizient rT1 = |0.82|, rT2 |1.00| Empirische Bildanalyse Validierung von RizbA an bildnerischen Arbeiten erwachsener Lai*innen Schoch K.1,2 & Ostermann T.1 1 Universität Witten/Herdecke, Fakultät für Gesundheit, Department Psychologie und Psychotherapie 2 Hochschule für Künste im Sozialen, Ottersberg, Institut für Kunsttherapie und Forschung Hintergrund Literatur Epstein, C. (2019, 22. März). Bildlicher Ausdruck von Depression: Erprobung des Ratinginstruments RizbA an Bildstichproben aus dem klinischen Kunsttherapiesetting. Zenodo. https://doi.org/10.5281/zenodo.3365921 Janßen, B. (2018, 31. August). Erprobung des Ratinginstruments für zweidimensionale bildnerische Arbeiten (RizbA): Ansatz zu einer möglichen Untersuchung des bildnerischen Ausdrucks von Schmerz in gemalten Bildern von Menschen mit chronischer Schmerzsymptomatik. Zenodo. https://doi.org/10.5281/zenodo.3407808 Schoch, K., & Ostermann T. (under review). Psychometrics of art: Validation of RizbA, a quantitative rating instrument for pictorial expression. Psychology of Aesthetics, Creativity and the Arts. Schoch, K. (2018). Ratinginstrument für zweidimensionale bildnerische Arbeiten (RizbA): Fragebogen in deutscher Sprache. Zenodo. DOI:10.5281/zenodo.2530858 Schoch, K. (2018). Jenseits von gut und schön: Entwicklung eines quantitativen Ratinginstruments für zweidimensionale bildnerische Arbeiten (RizbA). Musik-, Tanz- und Kunsttherapie: Zeitschrift für Künstlerische Therapien im Bildungs-, Sozial- und Gesundheitswesen. 28(2), 131-138. https://doi.org/10.5281/zenodo.1479716 Schoch. K., Gruber. H., & Ostermann, T. (2017). Measuring art: Methodical development of a quantitative rating instrument measuring pictorial expression. The Arts in Psychotherapy, 55, 73-79. https://doi.org/10.5281/zenodo.1479694 Diskussion • Reliabel und generalisierbar auf Bildmaterial von Lai*innen • Praxisdokumentation, Grundlagen- und Anwendungsforschung Dokumentation und Analyse von Bildern und Prozessen Korrelationen mit anderen Konstrukten Gruppenvergleiche • Abgeschlossen Dritte Validierungsstudie an Gegenwartskunst • Durchgeführt Pilotstudien zu spezifischen Populationen Chronische Schmerzsymptomatik (Janßen, 2018) Rezidivierende Depression (Epstein, 2019) • In Entwicklung Manual • In Planung Machine Learning-Ansätze kerstin.schoch@hks-ottersberg.de www.kunsthochzwei.com/forschung Tab.1. Antwortformat: Sechsstufige Likert-Skala trifft überhaupt nicht zu trifft nicht zu trifft eher nicht zu trifft eher zu trifft zu trifft voll- kommen zu ✘ Limitierung Weitere Validierung Faktorenstruktur CFA, SEM Weitere Populationen Bildmaterial und Rater*innen Tab.2. Fragebogen: Items und deren Gütekriterien (T1) Nr. Itembeschreibung pi si2 𝛈2 ICC 1 Das Bild enthält zeichnerische Elemente .58 1.31 .52 .96 2 Das Bild enthält malerische Elemente .61 0.92 .41 .93 3 Die Darstellungsweise ist gegenständlich .43 1.67 .63 .97 4 Die Darstellungsweise ist abstrakt .61 1.19 .52 .96 5 Der Farbauftrag ist pastos .33 0.63 .31 .90 6 Die vorherrschende Farbgebung ist leuchtend .58 1.08 .52 .96 7 Im Bild befinden sich vorwiegend reine Farben .47 0.52 .28 .88 8 Im Bild befinden sich vorwiegend Mischfarben (Sekundärfarben) .50 0.72 .36 .92 9 Im Bild sind Komplementärkontraste vorhanden .51 1.34 .51 .96 10 Im Bild enthaltene Formen sind vorwiegend organisch .52 0.65 .34 .92 11 Im Bild enthaltene Formen sind vorwiegend geometrisch .39 0.98 .46 .94 12 Die Linienführung verläuft vorwiegend gebogen .55 1.07 .50 .95 13 Die Linienführung verläuft vorwiegend eckig .30 0.90 .49 .95 14 Das Bild enthält unbearbeitete Flächen .53 1.72 .51 .96 15 Das Bild wirkt tief .32 0.44 .29 .88 16 Das Bild ist perspektivisch .33 0.62 .34 .91 17 Das Bild ist frei von Perspektive (aperspektivisch) .60 0.71 .31 .90 18 Das Bil


El riesgo CV , se define como la probabilidad de un individuo de tener un evento cardiovascular en un período de tiempo determinado (por ejemplo, en los próximos 5 o 10 años). La ecuación de riesgo de Framinghan define como un primer evento CV al IAM, angina de pecho, ataque cerebral isquémico, enfermedad vascular periférica, insuficiencia cardíaca congestiva o una muerte cardiovascular. El objetivo de hacer una evaluación del riesgo CV es identificar los factores de riesgo, estimar el riesgo de hacer un evento CV y utilizar este cálculo para hacer un manejo terapéutico apropiado de aquellos factores. El presente estudio se llevo a efecto en los CS. San Lorenzo , Pile , El Aromo , Manantiales , San Mateo , con una población de 32 personas , de las cuales se evidencia que 27/32 presenta un RCV bajo , 2/32 presenta un riesgo MUY ALTO , por ser diabéticos , y de riesgo moderado 3/32. Lo que llamo la atención fue que de los 32 evaluados 22 presentan SOBREPESO y 4 con OBESIDAD , además que el 100% del grupo es SEDENTARIO . Al momento no se encuentra implementado un programa de salud preventiva en nuestro distrito de salud , cosa alarmante , por eso la pregunta ¿ Se preocupa la salud por nuestra salud?? Quien se preocupa por que los funcionarios tengan SALUD ¿?.Los múltiples requerimientos no solo en el trabajo clínico si no administrativo absorbe de forma casi total el tiempo de los trabajadores , dando lugar al desarrollo de patologías que silenciosamente evolucionan tanto en la salud cardiovascular como HTA, DM , DLP , OBESIDAD , Problemas de salud mental como trastornos ansiosos , depresión etc . Es necesario la implementación de medidas que nos protejan , asegurando bienestar SALUD a los trabajadores del área de la salud , en aras de mejor atención a nuestros usuarios y al mejoramiento de el sistema de salud del país. RIESGO CARDIOVASCULAR EN EL PERSONAL DEL DISTRITO DE SALUD NUMERO DOS SECTOR RURAL SCORE DE FRAMINGHAN UNIVERSIDAD DE PIURA MAESTRIA EN SALUD OCUPACIONAL ¿ Hay salud en la salud? Distribución del Personal de salud del área rural , distrito 2 BAJO 5% MODERADO 5-9% ALTO 10-19% MUY ALTO 20 o > 0 2 4 6 8 10 Serie1 0 5 10 15 20 25 SOBREPESO BIBLIOGRAFIA . 1.Programa de Salud Cardiovascular. Reorientación de los Programas de Hipertensión y Diabetes. Ministerio de Salud de Chile. 2002 . Prevención Primaria de Enfermedad Coronaria. Tablas de Framingham para la estimación de riesgo coronario a 10 años adaptadas a la población chilena. Programa de Investigación de Factores de Riesgo de Enfermedad Cardiovascular. 2007. Universidad de Talca. http://pifrecv.utalca.cl . Determinación y Prevalencia de Factores de Riesgo Cardiovascular en el Personal de la Brigada de Caballería Blindada No 11 Galápagos, Riobamba ELABORADO POR: DRA SUSANA JASMIN CABRERA MERO MANTA OCTUBRE 2014 RIESGO CARDIOVASCULAR 22 PCTES CON SOBREPESO 4 CON OBESIDAD


We wish to thank the Allen Institute founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. An integrated imaging and staining platform for cubic millimeter scale array tomography Forrest Collman, Robert Seraﬁn, Sarah Davis, Olga Gliko, Tom M Keenan, Kristy Parker, Linnaea E Ostroﬀ, Stephen J Smith Synapse Biology Department, Allen Institute for Brain Science, Seattle WA 98103 Array tomography (AT) involves reconstruction of images acquired from arrays of serial ultrathin sections, which can be imaged by fluorescence microscopy (FM-AT) for proteometric analysis, or by scanning electron microscopy (EM-AT) for higher resolution. Axial resolution is defined by the thickness of physical sections (50-200 nm); the lateral resolution of FM imaging is optimal given the direct adhesion of sections to an optical coverslip. However, the throughput of data acquisition is slowed by the image acquisition time, and the need for human intervention to stain and set up samples on the microscope. The first AT systems acquired data at a throughput of ~16 seconds per 4 channel image (Micheva 2007). Recent work incorporated a hardware-based autofocus technology that improved throughput to 5-12 sec per 4 channel image (Rah 2013), achieving 0.1 mm3 in 878 imaging hours with 200 nm-thick sections. Data acquisition throughput is further impaired by the overhead involved in staining and setting the sample up for imaging. As part of the Open Synaptome Project (http://opensynapto.me) effort to improve all aspects of ATomo based synaptic analysis, we are developing a next-generation system to achieve imaging throughput on the order of 0.2mm3 per day per microscope. We will describe the design of the imaging system, which include hardware-based autofocus, large format sCMOS sensors, motionless high intensity wide-field laser illumination, and a custom open-source software solution. We will also describe our efforts to construct a robofluidic staining solution fully integrated with the microscope. Our goal is to enable continual staining and imaging without human intervention, thus increasing both throughput and consistency of results ultrathin section onto coverglass IF stain IF imaging poststain FESEM elution ABSTRACT ARRAY TOMOGRAPHY IMAGING brain-map.org alleninstitute.org y (mm) 0 ul 50 ul 100 ul 150 ul 200 ul 250 ul 300ul Fluorescein Intensity (AU) 0 500 100 200 300 400 Wash In x (mm) y (mm) Wash Out 0 ul 50 ul 100 ul 150 ul 200 ul 250 ul 300ul Fluorescein Intensity (AU) 0 500 100 200 300 400 x (mm) 300ul 0 10 x (mm) >95% washin with 200-250ul >99% washout with 300 ul Non-saturating/quenching concentration of fluoroscein 10x air objective, median intensity of field, 50μl increments Fully automated pipetting and image acquisition across x,y grid Pipette In Pipette Out 1.5 mm 3.25 mm pipetting robot inverted microscope 96-well chiller tips 45 mm 3D printed mold PDMS (Sylgard) poured mold Passive pumping design allows simple unpowered flow-cell compatible with vertical pipetting robot (Walker 2002) PASSIVE PUMPING FLOW CELL PROTOTYPE MOSAIC PLANNER - OPEN SOURCE ARRAY TOMOGRAPHY SOFTWARE REFERENCES AND GRANT SUPPORT COVERSLIP FLATNESS LASER ILLUMINATION time per 4 channel frame (sec) auto-focus filter-change exposure stage move Standard Upright Automated Microscope Zeiss Observer Z.1, 4 filter cubes, x-cite mercury halide liquid light guide IMAGING SPEED IMPROVEMENTS Improvement 16.1 sec per 4 images 892 images/hour hardware auto-focus (Rah et al. 2015) 100-400ms focus time ~2000 images/hour Estimated Speed Increase ~10-50 ms change time ~4000 images/hour quad band dichroic illumination switching sCMOS field size 4.2 vs 1.4 megapixels effectively 2.9x faster laser illumination ~5x power density ~12,000 images/hour NET IMPROVEMENT ~40x faster net imaging 500 nm X Y XY PSF 500 nm Z Y YZ PSF 50 100 1 nm/μm across 200 μm 500μm μmanager Core API hardware agnostic microscope commands images/status Camera Illumination Stage Microsc


ZENTRUM Für nachhaltiges Forschungsdatenmanagement Literatur Huschka, Denis et al. (Hg.) (2013): Forschungsinfrastrukturen für die qualitative Sozialforschung. Berlin: Scivero. RatSWD (Hg.) (2018): Archivierung und Zugang zu qualitativen Daten. RatSWD Working Paper 267/2018. Berlin: Rat für Sozial- und Wirtschaftsdaten (RatSWD). https://doi.org/10.17620/02671.35 Steinhardt, Isabel et al. (2020): Das Öffnen und Teilen von Daten qualitativer Forschung. Ergebnisse eines Workshops der Forschungsgruppe „Digitalisierung der Wissenschaft“. Weizenbaum Series 6. Berlin: Weizenbaum Institute for the Networked Society. https://doi.org/10.34669/wi.ws/6 POSTER Möllenkamp, Andreas (2020): Öffnen und Teilen von Interviews. Ein Leitfaden. Zenodo. DOI: https://doi.org/10.5281/zenodo.3925304 Lizenz Dieses Werk ist lizensiert unter der Lizenz Creative Commons Attribution 4.0 International (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ PROJEKT Das Poster ist entstanden im Rahmen des Projekts Open Interviews. Auf dem Weg zur Öffnung qualitativer Interviewforschung. Weitere Informationen: https://w.wiki/Vkp Das Projekt wurde das 2018/2019 im Rahmen des Fellow-Programm Freies Wissen von Wikimedia Deutschland, dem Stifterverband für die Deutsche Wissenschaft und der VolkswagenStiftung gefördert. KONTAKT Andreas Möllenkamp Universität Hamburg Zentrum für nachhaltiges Forschungsdatenmanagement Monetastr. 4 20146 Hamburg Tel.: +49 40 42838-7231 andreas.moellenkamp@uni-hamburg.de www.fdm.uni-hamburg.de https://orcid.org/0000-0002-5750-0220 https://twitter.com/andreasmoellen21 Vorbereitung und Planung Bei Qualifikationsarbeiten: Sprechen Sie mit Ihren Betreuer*innen über das Archivieren, Öffnen und Teilen von Interviews. Einen Überblick über das Öffnen und Teilen von Daten qualitativer Forschung bietet Steinhardt et al. (2020). Reflektieren Sie, ob in Ihrem Projekt durch das Öffnen und Teilen ein Eingriff in den Forschungsprozess entstehen würde. Eine Beeinflussung der Interviewsituation können Sie umgehen, indem Sie Fragen der Archivierung und Zugänglichmachung erst nach dem Interview besprechen, beispielsweise auf Grundlage des Interviewtranskripts.3 ÖFFNEN und Teilen von Interviews Ein Leitfaden Informieren Sie sich über geeignete Forschungsdaten-Repositorien. Der Rat für Sozial- und Wirtschaftsdaten akkreditiert Forschungsdatenzentren: www.ratswd.de/forschungsdaten/fdz/ qualitativ Das Forschungsdatenzentrum Qualiservice hat sich auf die Archivierung und Bereitstellung von Interviews und anderen qualitativen Daten aus der Sozialforschung spezialisiert. Lassen Sie sich dort beraten und planen Sie Zeit und Kosten für die Archivierung ggf. in Ihrem Förderantrag mit ein. www.qualiservice.org/ Illustrationen: digitalbevaring.dk (CC-BY 2.5 DK) Durchführung Dokumentation und Kontextualisierung: Für eine gute Nachvollziehbarkeit und Nachnutzbarkeit ist eine möglichst umfassende und prozessbegleitende Dokumentation und Kontextualisierung Ihrer Interviews wichtig. Dazu gehören die Mitglieder Ihres Forschungsteams, die Erläuterung der Auswahl Ihrer Interviewpartner*innen, die Kommunikation vor dem Interview, der Kontext der Interviewsituation sowie die weiteren Bearbeitungs- und Auswertungsschritte. Datenschutz: Als Forscher*in sind Sie verpflichtet, verantwortungsvoll mit den personenbezogenen Daten Ihrer Interviewpartner*innen umzugehen. Nach der Datenschutz-Grundverordnung (DSGVO) dürfen personenbezogene Daten nur für festgelegte, eindeutige und legitime Zwecke erhoben und verarbeitet werden. Darüber hinaus sind die Landesdatenschutzgesetze für öffentliche Hochschulen in Deutschland einschlägig. Die Erhebung, Verarbeitung und Archivierung von personenbezogenen Daten bedarf daher der informierten Einwilligung Ihrer Interviewpartner*innen. Informierte Einwilligung: Die Einwilligungserklärung einer Interviewpartner*in setzt voraus, dass Sie sie über Ihre Forschungsabsicht, das Vorgehen, die konkrete Nutzung der Daten und die Rechte der beforscht


Collaborative Research: Elements: ROCCI: Integrated Cyberinfrastructure for In Situ Lossy Compression Optimization Based on Post Hoc Analysis Requirements PIs: Sheng Di1,2, Franck Cappello1,2, Dingwen Tao3 1University of Chicago, 2Argonne National Laboratory 3 Indiana University Motivation Libpressio Z-Checker/QCAT Objectives This project aims to develop a Requirement-Oriented Compression Cyber-Infrastructure (ROCCI) for data-intensive domains such as astrophysics and materials science. The core purpose is practicality, enabling scientists to efficiently assess and/or optimize the lossy compression quality based on their post hoc analysis requirements. This project advances knowledge with three key thrusts: • It builds an efficient layer to interoperate with different lossy compressors and diverse post hoc analysis requirements on data fidelity by leveraging our developed compression adaptor library (LibPressio) and compression assessment library (Z-checker). • It develops an efficient engine to determine the best compressor with automatically tuned optimized settings. • It develops a user-friendly infrastructure integrating compression optimization and execution via HDF5 dynamic filter mechanism. Acknowledgement Z-checker is a parallel framework for assessing lossy compression of scientific data efficiently. QCAT is the corresponding lightweight utility library and toolkit. This research is supported by NSF OAC # 2104023 and 2104024. We acknowledge the computing resources provided on Bebop (operated by Argonne Laboratory Computing Resource Center and on Theta and JLSE (operated by Argonne Leadership Computing Facility). Publications Estimation error and cost of SECRE for SZx: When using a large sampling stride such as 40 (sampling rate would be 1/41≈2.43%), the estimation error is still very low less than 1% in the worst case). System Architecture of ROCCI with improved & innovative modules. We are towards the end of the second year of the project. In the first two years, we have 20+ papers published in top conference/journal papers, including SC, ICDCS, ICDE, IPDPS, HPDC, ICS, VLDB, EuroSys, IJHPCA, HiPC, etc.. Major Accomplishments First year: We improved Libpressio to support 30+ compressors (both lossy and lossless, both CPU and GPU) and Z-checker/QCAT to support 40+ compression assessment metrics (including ratio, speed, max error, PSNR, SSIM, derivatives, distribution of errors, auto- correlation of errors, visualization, etc.) Second Year: We explored a series compression quality estimation methods, by leveraging machine learning (ML), statistical analysis, compression-principle analysis (surrogate), sampling method, etc. We also improved the performance for Libpressio, Z-checker/QCAT, SZ3, SZx, and developed new capabilities such as QoZ, FAZ. Libpressio-Predict Compression Ratio Estimation Evaluation using 4 real-world science datasets including climate simulation, cosmology research, large-eddy simulation, etc. LibPressio provides a productive interface for integrating compression. It eases experiment with new compressors with less code and complexity. Compression developers benefit from using a common implementation for a parallel compression; a CLI; Python, Rust, Julia, C, C++ bindings; and HDF5, ADIOS2, and other integrations that are complete and consistent with just 1 C++ class. 1 API 32+ compressors Builtin Provenance Support Optional Automatic Configuration and Optimization CPU Parallel and GPU Parallel Compressors Non-measurable overhead CLI, Python, Rust, Julia, C, and C++ bindings LibPressio addresses all these issues by providing a unifying interface with advanced engines for provenance and configuration optimization. LibPressio-predict integrates quite a few compression ratio and metric estimation algorithms for error-bounded lossy compression, including FXRZ, SECRE, Stats-based compresibility estimation method, etc. We have developed multiple efficient compression quality estimation methods and error-con


Innovative Research for a Sustainable Future www.epa.gov/research Keith Houck | houck.keith@epa.gov | 919-541-5519 Predicting Toxic and Therapeutic Mechanisms of the ToxCast Chemical Library by Phenotypic Screening Houck K1, Kleinstreuer N2, Yang J3, Berg E3, Knudsen T1, Richard A1, Martin M1, Reif D4, Judson R1, Polokoff M3 1 National Center for Computational Toxicology, Office of Research and Development, US EPA, Research Triangle Park, NC; 2ILS, Inc., Research Triangle Park, NC; 3BioSeek, a Division of DiscoveRx, South San Francisco, CA; 4NCSU, Raleigh, NC Abstract Summary Results The ToxCast Phase II library was screened in 8 complex cell culture systems measuring endpoints relevant to inflammatory signaling and vascular biology. Assays showed strong reproducibility across technical replicates and built-in test compounds. The BioMAP system identified potential targets, modes of action, and clinical side effects for compounds based on the reference database. Assays provided coverage of mechanisms/targets not directly represented in assay endpoints, e.g. AhR Phenotypic screening and computational analysis provides a unique opportunity to survey environmental chemicals for potential human bioactivity Methods Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing. However the quantity of chemicals needing assessment and challenges of species extrapolation require development of alternative approaches. Using 8 primary human cell systems (BioMAP), we screened in concentration-response format 776 chemicals from the ToxCast Phase II library (http://epa.gov/ncct/toxcast/chemicals.html) for perturbation of physiologically important pathways. Cell systems consisted of combinations of endothelial, peripheral blood mononuclear, bronchial epithelial and coronary artery smooth muscle cells; fibroblasts and keratinocytes. Chemical-response signatures from 87 endpoints covering molecular functions relevant to toxic and therapeutic pathways were generated. Assessment of profiling data by unsupervised clustering using Self Organizing Maps and supervised analysis using Support Vector Machine algorithms grouped chemical/concentration by potential mechanism class providing insight into polypharmacology and potential off-target effects of drugs. Clusters contained diverse mechanistic activity including kinase, TNFα, phosphodiesterase and Hsp90 inhibitors; Ah, estrogen and glucocorticoid receptor modulators; disruptors of mitochondrial and tubulin function; histamine antagonists; and statins. Novel associations identified included induction of tissue factor in endothelial cells by ER antagonists, AhR agonists and mTOR inhibitors, all chemical classes with susceptibility to venous thrombosis. Further, structure-based analysis demonstrated associations between chemical categories and mechanism class predictions. Our results yielded an extensive list of potential toxicological targets and biological pathways that we are incorporating into a chemical prioritization strategy for chemicals of concern to the Agency. Objective Use primary human cell phenotypic responses to classify and predict compound mechanisms of action and potential toxicities Primary Cell Systems Used SVM Models and Top Scoring Compounds • Compounds were tested at 4 (or 8) concentrations in duplicate, 200 mM high concentration with half-log dilutions. • Cells treated with compounds followed at one hr by stimulation of signaling pathways • Cells harvested at 24 hr and endpoints measured by ELISA or staining (SRB) • Data normalized to log10 Fold Change over DMSO controls • AC50 values calculated using 4-parameter Hill model • Compounds tested in blinded fashion and included internal replicates • Predictive models for 28 mechanism classes were built using a two class approach with SVM using R SVM package e1071 (Berg et al., JBS 18:1260, 2013). • Unsupervised clustering of all compounds at the individual concentration level was conducted


Key partners: Sewer Mining (SM) technology is a mobile wastewater treatment system in containers able to extract wastewater from local sewers, treat it directly and reuse at the point of demand in dense urban environments. The unit consists of a membrane bioreactor unit (MBR) and a UV disinfection component and produces high quality reclaimed water for irrigation and for aquifer recharge during the winter. The SM unit has an annual capacity of about 9.000 m3 of reclaimed water Treatment residuals are collected, treated locally in the site and are transformed to an eco-friendly fertilizer (compost), when merged with green waste from pruning. Implemented technology The technology has been tested for over 1.5 year. Sampling and analysis activities have been implemented at a weekly basis and the main results that are illustrated in the table and the diagrams are summarized below: • SM produces water of a quality that meets all national and international criteria for unrestricted irrigation and urban use • Achieves complete elimination of organic carbon and pathogenic content • Provides reduction of pathogens due to MBR filtration process (without addition of chemicals avoiding production of secondary pollutants) • UV disinfection unit showed great performance • System works automatically and is remotely monitored in terms of operation and quality performance. Parameters Influent Effluent after UV disinfection Legislation Limits TSS 253± 97 ≤ 2 for 80% of samples ≤2 for 80% of samples ≤10 for 80% of samples BOD5 216 ± 64 8,6 ± 2,4 3 ≤10 for 87% of samples ≤10 for 80% of samples COD 695 ± 97 24,2 ± 4,1 3 - TN 81 (average) 5,5 ± 1,4 3 ≤ 15 NH4-N 5 ± 3 0,2 ± 0,19 3 ≤ 2 TP 10 ± 1.4 1,57 (average) - Turbidity - 2 (median) ≤ 2 (median) Conductivity 1,109 ± 75 1,067 ± 0 - pH 7.1 ± 0,2 7.5 ± 0,3 - TC >10 2 for 80% of samples 9 for 95% of samples ≤2 for 80% of samples ≤20 for 95% of samples FC >10 ≤3 - EC >10 ≤ 3 for 95% of samples ≤5 for 80% of samples ≤50 for 95% of samples Sewer Mining (SM) technology as a Distributed Intervention for Water-Energy-Materials in the Circular Economy: A Real World Demonstration in the Athens Plant Nursery Klio Monokrousou1, Christos Makropoulos1, Konstantinos Tsimnadis2, Georgios Katsouras3, Nikolaos Tsalas3 1. Department of Water Resources and Environmental Engineering, School of Civil Engineering, National Technical University of Athens, Heroon Polytechneiou 5, Zografou, 15780, Greece, kmonokrousou@gmail.com; cmakro@mail.ntua.gr 2. City of Athens, Department of Greenery and Urban Fauna, 5 Panag. Kanellopoulou, 11525 Athens, Greece, tsimnad@yahoo.gr 3. Athens Water Supply and Sewerage Company S. A (E.YD.A.P.) – Research and Development – 156 Oropou 11 str., 11146, Galatsi, Athens, Greece, gekats@eydap.gr; ntsal@eydap.gr Methodology Results The sewerage is extracted through two pumps that work alternately, from about four meters below the surface to fill in a buffer tank. The process starts when filtered wastewater enters a denitrification tank, where anaerobic microorganisms turn nitrates to nitrogen gas which naturally leaves the system. The denitrification tank communicates with a nitrification or aeration tank, where aerobic microorganisms turn reduced nitrogen compounds to nitrates. Subsequently, the biologically treated wastewater is transferred to the membrane tank and then the permeate passes through the UV disinfection unit and the final disinfected product flows naturally toward a storage tank to be reused mainly for irrigation purposes. The whole process is fully monitored through sensors and is automated using pneumatic actuated valves controlled by a PLC unit. The excess sludge produced from the SM unit along with the green and wood waste of the urban green spaces that end up in the Nursery, goes through a rapid composting process to produce on-site fertiliser. A heat exchanger and heat pump system recovers thermal energy from the wastewater to be reused for the technological processes of the c


Ruta alternativa Barranco Jabalí Ruta alternativa Trincheras Sendero Acequias de Paulo y El Coto Usted está aquí Mapa propiedad del Instituto Geográfico Nacional El municipio alpujarreño de Pórtugos, ubicado en el macizo granadino de Sierra Nevada, destaca por sus diversas fuentes y manantiales que abastecen de agua una importante red de acequias históricas. Estos nacimientos de agua se enriquecen con los aportes nivales y permiten dotar al municipio de abundante agua. Estos sistemas de riego existen, al menos, desde época andalusí y han generado numerosos espacios de cultivo, pastos y han modelado el paisaje, haciendo de este, un espacio singular. En En el caso del sendero Acequias de Paulo y El Coto, podremos apreciar, transitando por el camino de servidumbre de paso de la acequia, parte de un sistema ancestral de manejo de agua. Estas acequias, toman las aguas del río Jabalí y recorren zonas de alta montaña, guiándola hasta puntos muy concretos donde se “carea”. Esto, signiöca la inöltración del agua en la tierra de manera artiöcial, para recogerla, en zonas más bajas, un tiempo después. A través de diferentes puntos de interés, podremos aprender sobre estos regadíos de alta montaña: la gestión y mantenimiento por parte de las comunidades de regantes, sus beneöcios ambientales, infraestructuras asociadas a estas y otros elementos con los que nos encontraremos a lo largo del recorrido (más información en el código QR). Visitaremos un espacio alterado por el ser humano tradicionalmente, pero que respeta de manera equilibrada y eöciente el medio en el que se encuentra. RECUERDE: Manténgase Evite hacer ruido Respete los bienes y Mantenga limpio No se permite No se permite la No se permite la No se permite la en los caminos propiedades privadas este entorno encender fuego recolección de plantas captura de animales recolección de fósiles 2 2 2 3 DATOS TÉCNICOS: Tipo de sendero: Semi-circular Distancia del recorrido: 7,3 km Desnivel acumulado de subida: 503 m Desnivel acumulado de bajada: 503 m Tiempo estimado del recorrido: 3 h y 10 min. Señalización de Sendero Local (SL) Acequia El Coto I Acequia de Paulo Panorámica de Pórtugos Sendero ACEQUIAS DE PAULO Y EL COTO (PÓRTUGOS) SL-A 386 Ayuntamiento de Pórtugos https://regadiohistorico.es


U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov ►Comparison of the HT-H295R screening data analyzed by ANOVA with the summary results available from the OECD validation study suggests that the HT-H295R assay predicted T and E2 effects well. ►The maxmMd is a reproducible and quantitative metric to determine the magnitude of chemical perturbation of steroidogenesis in HT-H295R, representing a data-driven option for evaluating lists of chemicals. ►The number of steroid hormone significantly perturbed in the HT-H295R assay does not indicate the magnitude of effect on steroidogenesis, whereas the maxmMd can differentiate strong and weak modulators of steroidogenesis. ►Selectivity scoring is a useful method to filter HT-H295R pathway positives for additional screening. ►Future work will include more comprehensive benchmarking of the maxmMd metric, and further adapting the HT- H295R kinetic model based on time-course experiments. We use Mahalanobis distance to quantify disruption of steroidogenesis across 11 steroid hormone measurements. Mahalanobis distance incorporates the effect size for each steroid hormone measure after adjusting for covariance between the steroid hormone measures. Evaluating Perturbation of In Vitro Steroidogenesis Using a High-throughput H295R Assay Derik E. Haggard1,2, Agnes L. Karmaus1,2,3, Matt T. Martin2,4, Richard S. Judson2, R. Woodrow Setzer2, Katie Paul Friedman2 1ORISE Postdoctoral Research Participant 2National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency 3Currently at Integrated Laboratory Systems, Inc 4Currently at Drug Safety Research and Development, Global Investigative Toxicology, Pfizer Derik E. Haggard l haggard.derik@epa.gov l 919-541-0745 Background: Endocrine disruption is a toxicity of both physiological and regulatory importance; as steroid hormones regulate reproduction, development, and other biological processes, it is a priority to identify chemicals that may interact with production of these hormones. A high-throughput H295R assay (HT-H295R) was developed as part of the U.S. EPA’s ToxCast program that includes measurement of 11 hormones across the steroid hormone biosynthesis pathway expressed in H295R cells, including progestagens, corticosteroids, androgens, and estrogens. HT-H295R Screening: 2012 chemicals in single concentration screening, 656 in concentration-response. Objectives: ►Demonstrate that the HT-H295R assay may be used to predict testosterone (T) and estradiol (E2) production via comparison of the 25 reference chemicals in the OECD-validated H295R assay. ►Develop a statistical analysis that integrates data from 11 steroid hormones into a single numeric value that indicates the magnitude of effect on steroidogenesis in the HT-H295R assay. ►Begin development of a pathway-based kinetic model of steroidogenesis in HT-H295R. This poster does not reflect US EPA policy. D.E.H. was supported by appointment to the Research Participation Program of the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. EPA. ►A total of 107 chemicals were replicated across multiple blocks; of these, 94 chemicals (87.9%) had concordant maxmMd pathway responses. ►maxmMd values were compared to the sum of steroid hormone hit counts, as measured by ANOVA. ►The maxmMd provides a quantitative indicator of activity that can distinguish chemicals that exert different magnitudes of effect on steroidogenesis but have the same hit count. Effect Sensitivity Specificity Accuracy Testosterone up 1.00 0.89 0.90 Testosterone dn 0.67 0.92 0.83 Estradiol up 0.75 0.83 0.80 Estradiol dn 0.80 1.00 0.95 Left: The residual covariances of many hormone measures in HT-H295R are highly correlated. Middle: Example of Euclidean distance for correlated


Towards cell-inspired particle-based microrobots: Optimisation of the encapsulation of microparticles in lipid membranes Eugenia De Remigis1, Gaia Petrucci1, Elisa Roberti1, Dario Cecchi1, Hilda Gomez Bernal1, Elisa L. Petrocelli2, Jyoti Sharma1 , Francesco Bianciardi1 and Stefano Palagi1 1) The Biorobotics Institute, Scuola Superiore Sant’Anna, Pontedera (Pisa), Italy 2) Sapienza University of Rome (Rome), Italy Confinement of active matter can lead to the emergence of peculiar collective behaviour and interaction with the confining structure1,2. Encapsulating microscale active particles in flexible vesicles can be the basis for artificial active systems to study or emulate complex biological phenomena. ERC project CELLOIDS aims to employ this concept to fabricate soft, deformable and intelligent microrobots for medical applications, inspired by the amoeboid migration strategy of human leukocytes. Particle density has been shown to be crucial for the emergence of collective behaviour3,4. 1. Song, S. et al., J. Am. Chem. Soc. 144, 2022. 2. Vutukuri, H. R. et al., Nature 586, 2020. 3. Bricard, A. et al., Nature 503, 2013. 4. Buttinoni, I. et al., Phys. Rev. Lett. 110, 2013. 5. Pautot, S. et al., Langmuir 19, 2003. 6. Moga, A. et al., ChemBioChem 20, 2019. 7. Ghellab, S. E. et al., Biophys Chem 253, 2019. 8. NIST/SEMATECH e-Handbook of Statistical Methods, http://www.itl.nist.gov/div898/handbook/, accessed April 11, 2023. 9. Sakamoto, R. et al., Proceedings of the National Academy of Sciences 119, 2022. Icons from: Bioicons - high quality science illustrations Data analysis: ImageJ, Rstudio References Acknowledgements This work has been supported by the European Research Council under Grant Agreement No. 948590, project “CELLOIDS”. Further information Do not hesitate to contact us! eugenia.deremigis@santannapisa.it PI: stefano.palagi@santannapisa.it @MicroRobotLab @microrobot.lab Microscale Robotics Laboratory Optimization of microparticle encapsulation Objective 1: obtain controllable particle density Goal: design a bioinspired strategy to employ active microparticles as a propulsion system for ultra-deformable, autonomous microrobots. flexible membrane active core gives ultra- deformability and responsiveness allows for self- propulsion Fabrication of particle-loaded, phospholipid-based giant unilamellar vesicles (GUVs) by inverted emulsion method5,6 Critical process parameters • particle concentration in inner suspension • centrifugation acceleration and time Major issue: polydispersity in vesicle size and particle density Future directions Analysis: response surfaces7,8 Phase-contrast microscopy Motility of amoeboid model systems derives from the interaction with a confining environment9. Fabrication of GUVs encapsulating PS@Pt Janus microparticles A B Infiltration of empty/full GUVs in restrictive chambers Particle-loaded GUVs in confinement Objective 2: verify activity and stability GUVs + PS@Pt Janus microparticles in unconfined environment GUVs in hypertonic solution form protrusions, where active particles can move. Confinement of the GUV in an asymmetric restrictive environment Functionalisation of membrane phospholipids and Janus microparticles to induce contraction-based propulsion How to obtain directional movement of the GUV by exploiting the spontaneous behaviour of Janus microparticles? Activity Stability & Deformability contraction-based extension-based Response parameters • vesicle size • particle density combined Conclusions Objective 1: Results suggest that high particle concentration in the inner suspension helps obtain bigger and fuller GUVs. Long centrifugation time and high acceleration seem necessary to maximise GUV dimension; on the other hand, very high acceleration values could prove counterproductive for an efficient encapsulation. The optimal trade-off point is likely still outside the tested domain. hypertonic glucose solution 3% H2O2 in hypertonic glucose solution GUV suspension 1 2 3 no confineme


• Internationale Konferenzen zu historischer Datenkritik • Blog "Historical method under digital conditions" • Epochenspezifische Lehrpläne • Buch "Historical Data Criticism and Sustainable RDM" • Rechtliche Empfehlungen • Informationsdienst zu technischen Trends und Normen in anderen Ländern • Empfehlungen zu Datenkritik und FDM • White Paper zu ethischen Dimensionen in den Area Histories im digitalen Raum The Future of the Past Task Area "Data Literacy" • Data Literacy Bedarfserhebung • Regional Training Centers • Virtueller Beratungsservice • Virtuelle Trainingskurse • Data Literacy Schulungskatalog • Modell Curriculum • Lernmodule & Schulungsmaterialien • Pilotprogramm für Multiplikator:innen • Governance-Modell für Data Literacy Material-Akkreditierung Unsere Arbeitsfelder Data Literacy Bedarfserhebung Start "von Büchern zu Bytes" Publikation Fragebogendesign Internationale Konferenz "Epistemic Virtues in Digital History and Humanities" Start der Blogreihe "Was Historiker:innen und historisch Arbeitende ihrem jüngeren Ich raten würden" Publikation „Digital Monolingualism, Archives at Risk, and Global Views on Open Access“ Bereitstellung Data Literacy Bibliographie Gründung AG "Regional Training Centers" Kooperationsworkshop zu OER Sammlung von Data Literacy Lern- und Lehrmaterialien Mitwirkung Konzeption NFDI-Workinggroup "Helpdesks" Publikation Umfragebericht Data Literacy Bedarfe Veröffentlichung Data Literacy Trainingskatalog Publikation Whitepaper Data Literacy Kompetenzprofil Gründung AG "Data Literacy in der Lehre" Roundtable auf der CrossArea-Tagung zum Thema "The Future of the Archive(s)" 4memory.de | @NFDI4memory | 4memory@ieg-mainz.de gefördert durch Projektnummer 501609550 Mailingliste: E-Mail: contact@4memory-dataliteracy.de Wir sind eng vernetzt Auf dem Laufenden bleiben Veröffentlichungen auf Zenodo "Von Büchern zu Bytes" Veranstaltungsreihe auf YouTube Data Literacy Data Literacy Ausbildung Ausbildung Historische Historische Quellenkritik Quellenkritik & FDM & FDM Digitale Area Digitale Area Histories Histories 2023 2024 Dienste für Dienste für digitale digitale Forschung Forschung Workshop & Publikation "Area Histories und die NFDI4Memory: Zur Rolle der FID"


1 Online supplement for integrated production-transportation planning for supply chain with perishable food and shared returnable transport items APPENDIX A: THE FRAMEWORK OF THE DIFFERENTIAL EVOLUTIONARY ALGORITHM The framework of the differential evolutionary algorithm (DEA) is shown in Fig 1. The basic iteration process of the DEA is similar to other evolutionary algorithms, such as genetic algorithms. It starts with a randomly generated population of candidate solutions and iteratively improves these solutions through mutation, crossover, and selection operations, aiming to converge toward the global optimal solution. The main steps of the DEA are as follows: first, we randomly generate enough individuals as an initial population; second, in mutation operation, two individuals are randomly selected from the current population. A weighted difference vector is calculated between these individuals and added to a third individual to create a new individual; third, the crossover operation crosses the original individual and the mutated individual to generate a new individual; then, in the selection operation, individuals with better fitness values are selected for the next-generation population. For more details on the DEA, please refer to Kumar et al. [1]. Population initialization Stopping condition is satisfied No Mutation Crossover Selection Output the best optimal solution Yes Fig. 1. The framework of differential evolutionary algorithm. APPENDIX B: THE FRAMEWORK OF THE COLUMN GENERATION The framework of the column generation (CG) algorithm is represented in Fig 2. To apply the CG to our problem P1, we reformulate it appropriately into a set partitioning model (master problem MP) and |M| subproblems. At the initial iteration of the CG, we solve a smaller-scale restricted master problem RMP (i.e., with fewer variables than the original problem MP). Then, we solve the relaxation of RMP, calculate the dual value (i.e., shadow price) for each constraint, and input dual values into subproblems. Subsequently, subproblems are solved to check the variables that are not currently considered in the RMP to see if there are any variables that can reduce the total cost (i.e., their reduced cost, denoted as RC, is less than zero). If such variables are found, we add them to the RMP and return to solve RMP. This process is repeated until no new variables can enter the RMP to reduce the total cost (i.e., the RC is non-negative). For more details on the CG, please refer to Tempelmeier [2].


ANÁLISE GEOESPACIAL E TEMPORAL DOS INDICADORES DE ALTA COMPLEXIDADE EM SAÚDE NO ESTADO DE SÃO PAULO Breno Bologna, Laura Lopes Amaral, Ana Paula Romani, Larissa Mayumi Yokoi, Tiago Ribeiro de Oliveira, Harki Tanaka, Priscyla Waleska Simões Curso de Engenharia Biomédica, Programa de Pós-Graduação em Engenharia Biomédica Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas Universidade Federal do ABC / Santo André, Brazil 1. INTRODUÇÃO Procedimentos de alta complexidade são destinados a situações específicas e mais raras, entretanto o impacto financeiro desse tipo de procedimento é alto. Assim, essa pesquisa visa apresentar a taxa de internações de alta complexidade no Estado de São Paulo de forma a prover informações importantes para a gestão de saúde pública. 2. METODOLOGIA Estudo descritivo que utilizou dados secundários do Sistema de Informações Hospitalares (SIH/SUS), extraídos do TabNet/DATASUS distinguindo entre as macrorregiões e microrregiões do Estado de São Paulo, e entre os municípios da microrregião de São Paulo. Foram obtidas as internações de alta complexidade de 2008 a 2016, por local de residência e por grupos de procedimentos. Além disso a população de cada uma dessas regiões foi extraída do IBGE. Determinou-se assim a taxa bruta de internações de alta complexidade a cada mil habitantes para cada região. A partir deste indicador foi estimada a média, o desvio padrão e foram realizadas análises da evolução histórica. Além disso foram realizados cálculos de regressão linear, e estimados o coeficiente angular, o nível de significância e o coeficiente de determinação. Em todas as análises, considerou-se como estatisticamente significativo p<0,05. 3. RESULTADOS A série histórica evidencia que a média do Estado de SP aumentou nesses últimos anos, e ao observar as microrregiões com maiores e menores taxas, Barretos e Franco da Rocha, nota-se que o aumento foi distribuído entre as regiões (Figura 1 e Figura 2). O procedimento que resultou em maiores taxas de internação de alta complexidade foi a Cirurgia, com taxa média bruta de 2,8 e aumento ao longo dos anos. Os procedimentos clínicos, transplantes e procedimentos com finalidade diagnóstica revelaram taxas de 0,6; 0,4 e 0,1 internações a cada 1.000 habitantes, respectivamente, com poucas oscilações no período. 4. CONCLUSÃO O presente estudo resultou em indicadores que servem de insumo para decisões dentro da gestão pública baseada em evidências principalmente quanto à distribuição espacial de quem usa esse tipo de serviço. Futuras pesquisas devem investigar os indicadores e estatísticas associadas. Figura 1. Evolução Temporal das Taxas de Internação por Microrregião/SP No período entre 2008 a 2016, foram realizadas 1.537.476 internações de alta complexidade no Estado de SP, o que equivale a uma taxa bruta média de 4,0 internações a cada 1.000 habitantes CONTATO Profa Dra Priscyla Waleska Simões - pritsimoes@gmail.com Curso de Engenharia Biomédica / Programa de Pós-Graduação em Engenharia Biomédica / Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas/ Universidade Federal do ABC / São Bernardo do Campo (SP) / Brasil Figura 2. Distribuição Geográfica das Taxas de Internação (p/ 1.000 hab) por Microrregião/SP (a) e Macrorregião/SP (b)