Objective: The Strategic CMO drives clinical and product development strategy supporting commercialization and impacting corporate valuation through key internal and external stakeholder and investor interactions. Clinical Development designs and maintains currency of all studies; works cross‐functionally to incorporate and balance regulatory requirements, payer data needs, and operational constraints in study designs. Clinical Operations operationalizes study designs for data generation to support registrational submissions. Medical Affairs focuses on data analysis, distillation, and dissemination so all stakeholders get the most current and accurate information on safety, efficacy, method of action, and differentiation of the company’s products. Challenge/problem: An experienced medical professional becomes CMO at a pre‐IPO gene therapy company – an exciting opportunity with challenges. How does the CMO remain strategic and prevent relegation – addressing urgent operational issues instead of building out a well thought‐through medical office? The CMO leveraged external partners focused on Medical Affairs, Pharmacovigilance and Clinical Development to help build the function and execute the strategy. Solution: Start Lean. Build a scalable framework. Expand with triggers. Outcome: Hire effectively to focus on value generating pieces. Leverage contractors and consultants for short‐term SME needs. Develop growth plans, models, and strategic frameworks. Identify potential new hires in advance to prepare for growth. Driven by corporate, regulatory, and competitive factors, expand the medical organization accordingly. Switch contractors and consultants to FTE’s once the role is proven valuable and needed. Benefits: One of the most successful newly launched companies, on its way towards becoming a leading gene therapy company. The Strategic CMO drives product research and development strategy and provides key support in external stakeholder and investor interactions Data / Evidence Generation Confidence Generation Clin Dev Clin Ops Med Affairs Traditional Functions Bridge Roles Strategic Outcomes Pre‐clinical • Site Setup • CRO Management • GCP • Medical Writing • KOL Management • Patient Advocacy Engagement • Clinician Education / Pubs • Scientific Exchange • HEOR • Clinical <‐‐> Investor Relations/CEO • Clinical <‐‐> Commercial • Study Design • Clinical Research • Biostats Phases 1‐3 Pre‐Launch Submission & Approval Launch IND Expansion • Robust and flexible clinical development plan • Strong patient advocacy based on science • Compliant sites and operations • Scientific <‐‐> Commercial • Patient/Site/Clinician <‐‐> Company • Readiness against competitive factors • Key contributions to investment community stakeholders • Strong demand for company success from investor community – based on the data    Clinical Development designs and maintains currency of all studies; works with Clinical Ops, Regulatory and Commercial operations to incorporate any operational constraints and feasibility aspects Clinical Development Study Design Creation Biostatistics Clinical Research Operational Collateral Review Scientific Data Review Pre‐clinical to Medical Bridge Study Design Education • Study synopsis • Study protocol • Statistical Analysis Plan • Scenario planning based on external factors • Regulatory submissions • Competitor analysis Clinical Operations operationalizes the study design and is responsible for data generation to support registrational data submissions Clinical Operations Study Design Input Site Activation CRO Manage‐ ment Supporting Vendor Management Compliance and Assurance Data Manage‐ ment Contrac‐ ting Coordina‐ tion • SOPs and procedural documentation • Trial‐related collateral • Clinical data sets • Execution of studies based on timelines Medical Affairs focuses on data analysis, distillation, and dissemination to ensure external stakeholders get the most up to date and accurate information on the safety, efficacy, m


Activity You will need a door that separates a warm room and a colder room. It could be the front door if it’s cold outside. Make a thin strip of tissue. Open the door a tiny bit. Hold your tissue down low in the draft of air - which way is the air moving? The draft happens because cold dense air is moving into the warmer, thinner air. We experience the weather directly ourselves. We can investigate and understand the world around us. We can apply our knowledge to make our lives better and to help others and our natural world. As we learn more about how the weather works, we can become better at managing its impacts and more insightful about our impact on our world. INVESTIGATING Flood defences help protect our homes - for when it rains a lot! Some countries experience hurricanes – people know to minimise damage by boarding up their windows. Does thunder and lightning scare you or excite you?! How do we How do we make sense of the make sense of the weather? weather? Have you ever leant into a really strong wind and felt its force?


SCIENCE 2.0 & OPEN SCIENCE IN HIGHER EDUCATION PROJEKT IM FORSCHUNGSVERBUND INA BLÜMEL, TIB // TAMARA HECK, HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF // CHRISTIAN HEISE, OKFN // ISABELLA PETERS, ANSGAR SCHERP, ZBW // LUZIAN WEISEL, FIZ KARLSRUHE CHECKLIST – HOW CAN A LECTURER CONTRIBUTE TO OPEN LEARNING? Results from the OER Workshop, Feb. 2016, Berlin // CHALLENGES // REQUIREMENTS / FIRST STEPS // PERSPECTIVES / YOUR IDEAS OPEN COLLABORATIVE TOOLS: Wikis, discussion platforms, learning platforms OPEN COMMUNICATION: discussions and comment options, feedback options OPEN EDUCATIONAL RESOURCES: literature, presentations, learning material, exercises OPEN MUTUAL ENGAGEMENT: common goals, respect, open for diverse opinions, open for criticism Make yourself aware of how COLLABORATION and EXCHANGE qualitatively improve your lectures and those of others, e.g. referring to networking, visibility and reputation. Use Wikis, Etherpads and other COLLABORATIVE TOOLS REGULARLY in your lectures to be able to get student feedback concerning the tools’ usefulness and to encourage students to edit seminar material. Consider your teaching materials as “LIVING SLIDES” or “living handouts”. Establish a collaborative teaching process a) Try to INCLUDE EXTERNAL PARTNERS (universities, companies, ...) in your conception of team work to train realistic and hands-on project situations. b) Go along with the team work process and PAY ATTENTION to a well-balanced roles in the student teams. c) ASSESS collaborative student contribution (e.g. extra credits) Let your students know that collaborative work is an ESSENTIAL SKILL and important for their future profession because they will have to solve complex tasks and therefore need other peers to support them. Let your students EXPERIENCE REALISTIC and hands-on examples. Make them aware of the different roles that are essential in collaborative working (e.g. moderator, reviewer) and that are homogeneous and complementary. Show your students that collaborative working requires COMMUNICATION and COMPREHENSION about working processes, feedback processes as well as the future usage of collaborative content. ENCOURAGE THEM to use collaborative results for their studies. Establish exchange and communication about collaborative teaching and learning among your colleagues: a) CAMPAIGN FOR SUPPORT to foster collaboration and exchange as criteria for high-quality education. b) TELL YOUR COLLEAGUES, who might have objections against more openess, about your positive experiences like achieving higher learning satisfaction with open teaching scenarios. Mention chances that come with open teaching and communicate them to foster exchange among your colleagues. c) Let your colleages know that digital communication and collaboration (with and among students and also with colleagues) SAVES TIME AND WORK in the long run. OER Camp: http://bit.ly/OERcamp2016 Blogpost: http://bit.ly/OERcamp_workshop Please join the discussion: https://pad.okfn.org/p/science20_in_der_lehre_checklist Literature: Bocconi, S.; Kampylis, P.; Punie, Y. (2012). Innovating Learning: Key Elements for Developing Creative Classrooms in Europe. JRC Scientific and Policy Reports. Luxembourg: Publication Office of the European Union. http://ipts.jrc.ec.europa.eu/publications/pub.cfm?id=5181 McAleese et al. (2014). Report to the European Commission on New Modes of Learning and Teaching in Higher Education. Luxembourg: Publications Office of the European Union. OECD (2012). The next strand of the Innovative Learning Environments (ILE) project. Implementation and change. Retrieved Apr 26, 2016 from http://www.oecd.org/edu/ceri/49800333.pdf


We explore the complementarity between LHC searches and neutrino experiments in probing neutrino non- standard interactions. Our study [1] spans the theoretical frameworks of effective field theory, simplified model and an illustrative UV completion, highlighting the synergies and distinctive features in all cases. We show that besides constraining the allowed NSI parameter space, the LHC data can break important degeneracies present in oscillation experiments such as DUNE, while the latter play an important role in probing light and weakly coupled physics undetectable at the LHC. Neutrino Non-Standard Interactions: Complementarities Between LHC and Oscillation Experiments Sudip Jana Max-Planck-Institut für Kernphysik, Heidelberg, Germany 1. K.S. Babu, Dorival Gonçalves, Sudip Jana and Pedro A. N. Machado, arXiv: 2003.03383 [hep-ph]AbstractNeutrino NSI from EFTs to Simplified ModelsComplementarity between LHC and neutrino experimentsTowards a UV complete scenarioConclusionsBibliography We have explored the complementarity between neutrino experiments and LHC searches in probing neutrino NSI. It covers the full span of theory frameworks: effective field theories, simplified models, and an illustrative UV completion. The LHC sensitivities to NSIs display relevant synergies to oscillation results. Namely, (i) the breakdown of degeneracies among NSI and oscillation parameters, (ii) sensitivity to new phenomenological signatures at the LHC. As a by-product of our analysis, we have shown that the use of EFT at the LHC in estimating sensitivity to NSIs is not generally theoretically consistent. Any UV complete model of neutrino NSI is expected to provide a more extensive phenomenology, especially since neutrinos are in the same SU(2)L doublet as charged leptons. In this UV completion the B − L number is gauged, but only for the third family. Heavy mediators are strongly constrained by LHC data. Low mediators constrained by low-energy experiments. Low energy constraints, dedicated LHC searches, and missing energy signatures provide strong constraints for different masses of the mediator. For masses below about 10 GeV, low energy observables tend to dominate. In the intermediate regime 10 − 100 GeV, dedicated searches for visible signatures at the LHC become more relevant. Finally, from 0.1 − 1 TeV LHC mono-jet searches, low energy observables and electroweak precision observables (up to the T parameter model dependence) play the leading role. This makes manifest the complementarities among collider data, oscillation measurements, and other low energy observables. Differently from the LHC, the effects of NSIs in neutrino oscillations strongly depend on the flavor structure of the NSI and the oscillation channel being studied. The effects of different NSIs and/or variations of the standard oscillation parameters can, in some cases, compensate each other and lead to well known degeneracies. Disentangling those is a difficult task at neutrino facilities. In contrast, the mono-jet signal at the LHC, does not distinguish between different choices of flavors i.e., they all lead to the same observables. Besides constraining the currently allowed NSI parameter space, this feature can be further exploited to break relevant degeneracies. The LHC sensitivity displays a strong dependence on the mediator mass, but it is free of parameter degeneracies. Neutrino oscillation measurements, on the other hand, exhibit the opposite behavior: significant degeneracies and no mediator mass dependence. The matter potential induced when neutrinos travel through a medium is not affected by a diagonal, universal contribution (as this just induces an overall phase shift on the neutrino state). On the other hand, LHC data is sensitive to each and all NSI parameters independently. Neutrino oscillations are not sensitive to axial interactions, while LHC data is sensitive to both vector and axial new physics contributions. All these features s


A Case of Racial Discrimination: Azeglio Bemporad, astronomer poet Angela Mangano INAF- Catania Astrophysical Observatory, Italy The stories from our archives do not only speak of scientific progress, tools and data, but also of the events of the astronomers as men, and the intertwining of their work and private, political and social life. In the case of Azeglio Bemporad, who worked at Catania Astrophysical Observatory until 1938, year of purge against Jews in Italy, the painful history of Fascism enters fully our scientific institutions, changing the life of a person who had never dealt with politics. Documents: Doc. 1: Letter n. 751 dated 17 June 1938/XVI, sent from Azeglio Bemporad to Minister for National Education, in: Historical Archive of Astrophysical Observatory in Catania, Correspondence Series, B. 5, f. 6 Doc. 2: Circular Letter n. 12336 dated 9 August 1938/XVI, sent from the Cabinet of the Minister for National Education Giuseppe Bottai, regarding: “Census of the staff of Jewish origin”, in: Historical Archive of Astrophysical Observatory in Catania,Correspondence Series, B. 5, f. 6 Doc. 3: Letter n. 845 dated 11 February 1939/XVII, sent from the Ministry for National Education, regarding: Handing over of the Osservatorio Astrofisico from prof. Azeglio Bemporad to Dr Luigi Taffara, in: Historical Archive of Astrophysical Observatory in Catania,Correspondence Series, B. 5, f. 7 In December 1938/XVI, Azeglio Bemporad, after having been forced to abide by all the provisions passed by the Government with regard to Jews, had to abandon his work, studies and ambitions as astronomer, handing everything over to Luigi Taffara (1881-1966), as Director-in-charge. Also the proposal which he had submitted to the ministry for completing work on the Astro-photographic Catalogue, completing its volumes totally free of charge, was rejected, and the assignment was transferred to Giuseppe Alessandro Favaro through the following letter: From: MINISTRY OF NATIONAL EDUCATION Rome, February 11th 1939/XVII No. 845 SUBJECT: Catania Astrophysical Observatory Delivery made by Prof. Bemporad Azeglio to dr. Luigi Taffara I have read the Observatory delivery report by prof. Azeglio Bemporad. Please communicate to Prof. Bemporad that I entrusted the completion of the astrographic catalogue to prof. Giuseppe Alessandro Favaro, who was appointed by me to go there and detect all the data, and if necessary, all the material related to the catalogue. Then you will want to communicate to prof. Bemporad that no later than the end of the current month he must leave the accommodation currently occupied by him in the Observatory. I look forward to an assurance of performance. (see doc. 3) It was a tremendous blow to see the work on the Catalogue taken away from him, to which he had devoted such passionate and constant effort throughout his lifetime and for which he had received recognition at international level. Indeed, during the International Astronomical Union Congress in Paris in 1935, he had been officially praised for making so much progress as regards the calculation and publishing work of the volumes in the Catania area, compared to other observatories. In the early months of 1939, he was forced to leave his quarters at the Observatory where he lived with his family. Other painful events followed this adversity: he moved to Adrano, at the foot of Mount Etna, and in 1943 his wife Annita Cingoli (1873-1943) died of a serious illness; then his house was burnt down by a fire caused by bombing during an air raid, which he miraculously escaped as did his son Guido and daughter Bice. At last, on the 28th of December 1943, the allied forces invaded the island; he was reinstated in his capacity as Director, but he was no longer able to conduct any scientific work due to ill health. He died in Catania on the 11th of February, 1945. Azeglio Bemporad, born in Siena on March 19th 1875, attended the Liceo Classico Forteguerri in Pistoia, and the humanities rem


Exploring New Physics with PandaX-4T Low Energy Electronic Recoil Data Xinning Zeng PhD Student on behalf of PandaX xinningzeng@sjtu.edu.cn Dual Phase Liquid Xenon TPC Why LXe TPC? 1. Large A: large cross section & self-shielding; 2. 3D reconstruction and fiducialization; 3. Scalable; 4. Discrimination power. Detector Response 1. The detector response of low energy electronic recoil events is modelled by NEST ( Noble Element Simulation Technique); 2. Detector parameters (e.g. recombination rate, photon detection efficiency) are fit to Rn calibration data using unbinned likelihood fitting with emcee; 3. Calibrated NEST also fits well with sliced calibration data. The PandaX-4T experiment operates a dual-phase liquid xenon time projection chamber (LXe TPC) that is located in China Jinping Underground Laboratory. Energy release in xenon will produce prompt scintillation photon signals (S1) and ionized electrons. Electrons drift up under the inﬂuence of a downward electric field in the SV, and the delayed electroluminescence signals (S2) are generated in the gaseous xenon region with a much stronger electric field. Background Level Sensitivity to New Physics • Tritium spectrum identified in the data, which is likely originated from the tritium calibration at the end of PandaX-II; Tritium estimation comes from pre-fit of S1 spectrum, since no extra experimental constraints; • Beta events from 214Pb/212Pb is monitored by (5.5/8.8 MeV) 𝜶of 222Rn/220Rn. The activity of 214Pb is estimated to be 4.50 ± 0.20 µBq/kg (Run 0) and 5.52 ± 0.25 µBq/kg(Run 1), and 212Pb is estimated to be 0.28 ± 0.08 µBq/kg; • Beta events from 85Kr based on the delayed 𝛽−𝛾coincidence events of meta-stable state 85mRb, the activity of 85Kr is estimated to be 0.52 ± 0.27 ± 0.01 ppt and 0.94 ± 0.28 ± 0.02 ppt for Run 0 and Run 1; • Radioactivity of materials of the detector are estimated from high- purity Germanium counting-station and detailed fit of 0.44 - 2.6 MeV spectrum. • Long lived xenon isotopes, including 136Xe and 124Xe are calculated based on the measured half-life; L-captures (5.2 keV) of cosmogenically activated 127Xe in Run 0 is fitted from K-capture (408 keV); • Solar neutrinos are calculated using Standard solar models and the standard model anomalous magnetic moment; • Accidental backgrounds, resulting from the random pairing of S1 and S2 signals are estimated to be 7.6 ± 2.4 (Run 0) and 7.1 ± 2.3 (Run 1). Axions and Neutrinos from Sun 1. Axion production in the sun: Atomic recombination and deexcitation (ARD), Bremsstrahlung, and Compton (ABC); Primakoff effect; M1 nuclear transition of 57Fe (14.4 keV). 2. Neutrinos may have abnormally large magnetic moment due to the Majorana nature or exotic new physics beyond the Standard Model. Detection in PandaX-4T: 1. axio-electric effect; 2. inverse Primakoff effect; 3. neutrino-electron scattering. XXXI International Conference on Neutrino Physics and Astrophysics June 16-22, 2024 Milan, Italy Data and Bestfit A background-only fit is applied to check the consistency of data and background model. 1. Region of interest: qS1 > 2PE, E < 30 keV and above the ER 99.5% quantile; 2. 1D binned likelihood fit is used based on HistFitter; 3. Systematics including error of detection efficiencies and light/charge yield are added to fit; 4. The data are consistent with the background-only hypothesis: 𝜒!/NDF = 32.0/24. Based on CLs+b technique, model-independent sensitivities with 90% confidence level (C.L.) of axion couplings (gAe,gAegAN,gAγ), and neutrino magnetic moment µν are derived. 182 preliminary preliminary Details can be found in https://doi.org/10.48550/arXiv.2403.04239 Acknowledgement: Thanks for the mentioned theoretical works and the photographer Shibo Zhang preliminary preliminary preliminary preliminary


2. Collecting wild-type accessions of Marchantia (and Lunularia). David J. Hoey1,2., George Greiff1., Ed Harris1,2., Karima El Mahboubi3., Santiago Farias1., Philip Carella1,4., SLCU Outreach Consortium1., Pierre-Marc Delaux3., Sebastian Schornack1,2. 1.Sainsbury Laboratory, University of Cambridge, United Kingdom; 2.Department of Plant Sciences, University of Cambridge, United Kingdom; 3.Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, Centre National de la Recherche Scientifique, Université Paul Sabatier, INP Toulouse, France; 4.John Innes Centre, Norwich, United Kingdom. Natural variation in oomycete infection of Marchantia polymorpha 6. qPCR quantification of Phytophthora infection across accessions is in progress, with a goal of a linear assembly of this trait. 7. Future steps: genome wide association studies will reveal novel factors of resistance/susceptibility in this model pathosystem. 1. Introduction • Liverwort and angiosperm lineages diverged around 450 million years ago. • Infection of Marchantia polymorpha has been established as a model pathosystem for macroevolutionary studies in oomycetes, fungus, and bacteria. • Phytophthora palmivora is a hemi-biotrophic broad-host, and infects through air chambers and colonises the upper photosynthetic layer. • Most studies of Marchantia are on a small number of accessions, and the genomic resources which are available for other more established model organisms are not currently available. • Our aim is to establish these genetic resources, and our working hypothesis is that variation in the infection of natural accessions of Marchantia is caused by variable genetic elements. We have so far collected 92 accessions of Marchantia polymorpha: some through our citizen science project, and some by us and collaborators on field trips or holidays! Male and female accessions were determined by amplification of PCR markers. Summary & Conclusions: • Marchantia polymorpha and Phytophthora palmivora are a model pathosystem for macroevolutionary studies. • However, as a relatively new model system the genetic resources which are available for other systems are not yet established. • We are working to establish these resources for the community by collecting and sequencing accessions. • Most accessions display intermediate symptoms, though some are very resistant and some are very susceptible. • None of the accessions tested so far are completely resistant to the pathogen. • We plan to use the Marchantia-Phytophthora pathosystem as a quantitative trait for future genome-wide association studies. Initial proof-of-concept experiment. qPCR data showing 2 susceptible, 2 intermediate, and 2 resistant accessions collected at a single time point. N=4, each data point performed in triplicate. Each sample contains 3 individual plants. Statistical groupings from Tukey's HSD post-hoc analysis. In meta-analysis of separate infection experiments, we will use TAK1 (susceptible) and TAK2 (resistant) as baselines for pathogen biomass. Acknowledgements: Thanks to all of the Schornack group for useful discussions and contributions. Thank you to Elisa Mogollon-Perez for regular maintenance of these lines. Thank you to the SLCU Events team for their coordination of the outreach events. This project was funded by the Gatsby Foundation. The members of the SLCU Outreach Consortium who contributed to the Great British Liverwort Hunt project are as follows: David Hoey, Sebastian Schornack, Edwige Moyroud, Alan Wanke, Alessandra Bonfanti, Stefano Gatti, Lauren Gardiner, Martin Balcerowicz, Alexander Summers, Elisabeth Burmeister, Kathy Grube, Andreea Alexa, Nataliia Kuksa, Jemma Salmon, Bryony Yates, Lucie Riglet, Elena Salvi, Ian Burrow, David G. Hill, The Roberts Family, Peter & Theresa Rooney, Jennie Showers, Anthea Wilson, and 59 anonymous contributors from the British public. Email/crsID: djh248@cam.ac.uk Twitter: @DavidJHoey Infected Marchantia polymorpha (5dpi) 3. WT accessions of Mar


Exploring the Interaction between Phytophthora palmivora and Oil Palm through Gene Co-expression Network Analysis Mariandrea García-Gaona1, David Botero-Rozo 1, Leonardo Araque1, Hernán Mauricio Romero 1,2 1Biology and Breeding Program, Colombian OiI Palm Research Center, Cenipalma. 2Biology Department, Universidad Nacional de Colombia Created with BioRender Poster Builder INTRODUCTION Phytophthora palmivora, the causal agent of Bud Rot (BR) in oil palm (Elaeis guineensis Jacq.), is responsible for significant crop losses in Colombia, affecting over 145,000 hectares in the last decade. Recent advancements have improved our understanding of P. palmivora's virulence mechanisms and host resistance. However, several unknown aspects remain, particularly concerning the oil palm host. In a transcriptomic study by Avila-Mendez et al. (2019), the interaction between P. palmivora and oil palm was investigated through a transcriptomic approach, with a focus on susceptible (Clon57) and resistant (Clon34) oil palm genotypes. Using RNAseq data from this study, we aimed to construct gene co-expression networks for both the pathogen and oil palm during compatible and incompatible interactions. Through this approach, we identified co- expressed gene hubs in P. palmivora that may play important roles during oil palm infection. Additionally, we observed signs of pathogen manipulation in susceptible oil palm materials, triggering an exaggerated response and compromising the phenylpropanoid pathway. In contrast, resistant oil palm materials demonstrated control over their response through putative Heat Shock Proteins (HSP), maintaining a balance between primary metabolism and biotic defense. Overall, this study provides insights into the molecular mechanisms underlying the interaction between oil palm and P. palmivora, which can contribute to the effective control of Bud Rot. METHODS RESULTS 1. P. palmivora gene networks exhibited distinct behaviors in response to Oil palm Clon34 and Clon57 P. palmivora-Clon34 grouped 251 differentially expressed genes of P. palmivora, and P. palmivora-Clon57 grouped 265 genes. The size of the nodes indicates their hub score, and the background colors correspond to modules or co-expressed groups. 3. Oil palm Clon34 and Clon57 exhibited different responses to P. palmivora GCN of Clon34 grouped 649 genes out of 1486 DEGs, with a correlation greater than 0.8 distributed in 27 modules, while GCN of Clon 57 grouped 1327 genes, distributed in 35 modules. 2. Biological Process GO terms enriched by P. palmivora in Clon57 Bar graph of P. palmivora . Graph shows the top 10 Biological process significantly enriched terms (p-value < 0.05) in interaction with oil palm. 4. Biological Process GO terms enriched by oil palm in response to P. palmivora. Bar graph of Oil Palm GO term enrichment analysis. Graph shows the top 20 Biological process significantly enriched terms (p-value < 0.05) in response to P. palmivora infection 5.Trends of gene expression for central genes during P. palmivora infection and oil palm defense Heatmap depicting gene expression patterns of central genes obtained form the GCNs.The color scale indicates relative expression levels, with red representing higher expression and blue representing lower expression. Row clustering was performed using correlation analysis. Row names correspond to gene annotations, and column names indicate the three time points (24, 72, and 120 hpi) for Clon34 and Clon57. CONCLUSIONS The co-expression networks of P. palmivora during successful infection in Clon57 showed that central or hubs were linked to genes associated with oxidative processes, NADH dehydrogenase, sulfur transporters, cytoplasmatic effectors, as well as elicitins and hydrolases. In the susceptible Clon57 genotype, there was enrichment and positive expression of genes related to abiotic stress, which can be attributed to the influence of P. palmivora during its infection process. The co-expression networks of th


MÉTODO DATOS BRUTOS Y MATERIAL SUPLEMENTARIO EN PUBLICACIONES SOBRE CIENCIAS DE LA EDUCACIÓN RESULTADOS DISCUSIÓN/CONCLUSIONES REFERENCIAS Autores: Martínez-Córdoba, C., Alonso-Arroyo, A., Chiva-Sanchis, I., Aleixandre-Benavent, R. y Valderrama-Zurián, J.C. Universitat de València INTRODUCCIÓN Compartir datos aumenta la velocidad de la investigación y ahorra tiempo y recursos, además de garantizar la transparencia y la reproducibilidad. En las ciencias de la educación, la puesta en común y la reutilización son cruciales, ya que la educación es la base del progreso socioeconómico. OBJETIVOS Describir el estado del intercambio de datos en el área de ciencias de la educación. UNIDADES DE ANÁLISIS Se descargaron 513 registros con datos asociados en categorías temáticas educativas de Web of Science entre 2021-2022. VARIABLES E INSTRUMENTOS Tipo de datos asociados, de formatos utilizados para registrar dichos datos y repositorios depositados que contenían los artículos recuperados. Se usaron Access y Excel para el análisis de las mismas. PROCEDIMIENTO Se descargaron artículos indexados en categorías temáticas educativas de WoS entre 2021-2022 que contenían datos asociados y se analizaron las variables señaladas, así como su relación con la categoría temática y la calidad de las revistas. ANÁLISIS DE DATOS Los datos se importaron al software propio Bibliométricos para realizar las consultas y obtener los resultados y, posteriormente, se trasladaron a Excel para poder elaborar las gráficas y agrupar los datos de acuerdo a las variables de interés. WoS incluyó 78.859 registros, de los cuales 513 (0,7%) incluían datos complementarios: el 55,4% (284) era material suplementario y el 29,4% (151) eran datos asociados. Los repositorios más utilizados fueron Open Science Framework (23), Dataverse e IRIS (7). Los 513 trabajos se publicaron en 241 revistas, destacando Frontiers in Education (38) y Education Sciences (13). Existen hasta 18 tipos de formatos en los registros con material suplementario, predominando pdf (177 registros) y doc/docx (75) (figura 1). Hay hasta 39 tipos de formatos diferentes en los registros con ficheros de datos asociados (figura 2). Los porcentajes de artículos con datos asociados son bajos y predominan los formatos propietarios sobre los libres y reutilizables. La promoción de políticas de intercambio de datos en el área de ciencias de la educación es esencial y necesaria para investigadores/as, autoridades académicas, gestores de investigación y especialistas en información. • Logan JAR, Hart SA, Schatschneider, C. Data sharing in Education science. AERA Open, 7(1): Article Number: 23328584211006475. DOI: 10.1177/23328584211006475 • Makel MC; Hodges J; Cook BG; Plucker JA. Both questionable and open research practices bare prevalent in Education research. Educational Researcher, 50(8): 493-504. DOI10.3102/0013189X211006440 Project TED2021-131057B-I00 funded by: Figura 1. Formatos material suplementario Figura 2. Formatos datos asociados


A novel in situ method for characterizing catheter-associated biofilm formation Elliott W. Welker, Tanner J. Barnharst, Bridget E. Eklund, and Nathan A. Fisher North Dakota State University, Department of Veterinary and Microbiological Sciences, Fargo, ND Isolate Information Isolate ATCC Source Acinetobacter baumannii 19606 Urine Acinetobacter baumannii BAA-‐747 Ear Pus Acinetobacter species 49139 Clinical Isolate Enterobacter cloacae 35030 Quality Control Strain Enterobacter cloacae 13047 Spinal Fluid Enterobacter cloacae 23355 None Speciﬁed Klebsiella pneumoniae 33495 Human Urinary Tract Klebsiella pneumoniae 700603 Urine Klebsiella pneumoniae 35657 Qualty Control Strain Pseudomonas aeruginosa 19429 Urine Pseudomonas aeruginosa 35554 Qualty Control Strain Pseudomonas aeruginosa 27853 Blood Culture Stenotrophomonas maltophilia K279a Blood Stenotrophomonas maltophilia D457R Branchial aspirate Stenotrophomonas maltophilia 2004-‐24-‐121 PaNent Table 1 The isolates were obtained from the American Type Culture Collection (ATCC). Isolates were selected based on their ability to form varying strengths of biofilms. Methods A panel of gram negative nosocomial bacteria were streaked for isolation onto Luria Bertani (LB) agar plates. Broth cultures were created in tryptic soy broth (TSB). 24G x ¾“ intravenous catheters were submerged in overnight broth cultures for two hours to facilitate attachment. Catheters were implanted inside the abdomen of the Blaptica dubia cockroach and incubated for 24 hours at 37°C for the in situ assay . Catheters were incubated in TSB broth at 37°C for 24 hours for the in vitro assay. The catheters were then removed or extracted from their respective incubation locations then washed with a saline solution. The catheters were placed in a solution of crystal violet for 15 minutes, washed with saline, then solubilized in ethanol. Aliquots were transferred to microplate and read at 600 nm. Fig. 4 Site of catheter insertion Fig. 3 Teflon intravenous catheter components Our research goal is to compare biofilm growth of several nosocomial isolates on intravenous catheters using a Blaptica dubia cockroach as a host. This novel method will also be compared to biofilm growth on the catheter using an in vitro model. Crystal violet stain will be used as a method to quantitatively asses biofilm growth. We hypothesize that the physiology of biofilm formation varies in an in vivo environment compared to in vitro due to immunological pressures. Fig. 2 Representative MicroCT images of a i n t r a v e n o u s c a t h e t e r i m p l a n t e d i n t o t h e abdominal cavity of Blaptica d u b i a . I m a g e s w e r e captured using the GE v (tome) x 240 kV microfocus X-ray computer topography system at the NDSU electron microscopy center. Panel A and B show lateral and longitudinal sections respectively. Panel C shows a computer 3-D model. Together these images show that the implanted catheters (the arrow) are positioned directly beneath the roach epidermis and that internal organs are not punctured during the implantation process. Fig. 1 Representative SEM images of intravenous catheters colonized by Stenotrophomonas maltophilia in the roach in situ model. Images were captured using a JOEL JSM-7600F scanning electron microscope at the NDSU electron microscopy center. Panel A shows biofilm accumulation (arrowhead) on the internal and external walls of the catheter. Panels B and C show the structure of biofilms including bacterial cells embedded within the extracellular polymeric substance (EPS), complex columnar architecture (COL), and association with insect immune cells, termed hemocytes (HE). Results & Discussion Fig. 5 results of Stenotrophomonas maltophilia in vitro and in vivo catheter biofilm formation The Stenotrophomonas maltophilia strains (Fig. 5) form statistically different amounts of biofilm in the in vitro and in vivo environments and in one strain (Sm 2004-24-121), the in vivo growth was markedly increased.


Temperature increases cause transposon-associated DNA damage specifically in spermatocytes Nicole A. Kurhanewicz, Devin Dinwiddie, Zachary D. Bush, and Diana E. Libuda University of Oregon, Institute of Molecular Biology, Department of Biology Sexually-reproducing organisms use meiosis to generate haploid gametes, such as sperm and eggs, to transmit their genome to the next generation. All tissues are susceptible to dramatic increases in temperature; however, developing sperm in the testes are unusually sensitive to small temperature fluctuations. Failure to thermoregulate spermatogenetic tissue and prolonged exposure to elevated temperatures are linked to male infertility. Further, temperature increases are known to cause DNA damage in spermatocytes, but the molecular mechanisms underlying this damage are unclear. Here we show that upon a brief heat-shock, the spermatocytes (but not oocytes) of Caenorhabditis elegans exhibit an increase in double strand DNA breaks (DSBs), that these temperature-induced DSBs occur via a SPO-11 independent pathway, and occur concurrent with impaired male fertility and temperature-induced transposon activity within the genome. Introduction Double strand DNA break (DSB) formation in Meiosis Figure 2. SPO-11 is a conserved endonuclease that induces double strand DNA breaks (DSBs) during meiosis. Soon after a DSB is formed, the recombinase RAD-51 binds to the 3’ DNA overhangs surrounding the DSB site. RAD-51 is required for DSB repair during meiosis and serves as a marker for meiotic DSB formation. A subset of DSBs are repaired as crossover recombination events, which are required to form the chiasma between homologous chromosomes necessary for proper chromosome segregation during the meiosis I division. Acute exposure to elevated temperature induces DSBs specifically in C. elegans spermatocytes Figure 3. (A) Immunofluorescence for the recombinase RAD-51 (green) and DNA/DAPI (blue) reveals that a two-hour 34°C heat shock causes a dramatic increase in RAD-51 foci (green) per nucleus (DNA in blue) specifically in wild type spermatocytes throughout the meiotic region of the male germ line. (B) Wild type oocytes do not exhibit any temperature-induced RAD-51 foci in any part of the meiotic prophase I. Temperature-induced DSBs progress with repair less than 3 hours after formation in spermatocytes Figure 7. The appearance and disappearance of a RAD-51 focus indicate the initiation and subsequent progression of a DSB through a repair pathway. Measurement of RAD-51 foci counts before heat shock and at 1-hour time points following heat shock reveal that most, if not all, of the temperature-induced DSBs have unloaded RAD-51 and progressed down a repair pathway by 3 hours following heat shock. Funding Sources Increase in Tc1 transposon expression and insertion sites correspond with temperature-induced DSBs Figure 9. Quantitative PCR for Tc1a and Tc3 transposase expression reveals that Tc1a transposase expression and not Tc3 transposase is increased significantly following heat shock. Expression levels were all normalized to act-1 expression levels. 1. Increased temperatures cause RAD-51 marked DNA damage specific to spermatocytes during meiotic prophase I. 2. Temperature-induced DNA damage forms SPO-11 independent double strand DNA breaks that have the capacity to repaired as crossover recombination events. 3. Temperature-induced DNA damage during meiotic prophase I correlates with reduced male fertility 4. Tc1 transposons excise and insert into the genome upon temperature increases in wild-type spermatocytes. Summary Tc1 transposon positions in the spermatocyte genome become altered following temperature increases Figure 10. Tc1 mobility was assessed globally and across individual chromosomes. (A) Inverse PCR paired with amplicon sequencing was used to identify Tc1 locations genome-wide. Representative plots for Chromosome II from adult males and hermaphrodite populations are shown. (B) To evaluate transposo


Wind Prominence References [1] Jardine +, MNRAS, 482(3), 2019 [2] Ferreira, MNRAS 316(3), 2000 [3] Wood +, ApJ, 628(2), L143, 2005 The distribution of prominence mass around a star is dependent on the tilt of the dipole axis. Bistable stars The exceptions are the bistable (very low mass) stars which show lower than expected Ms. This is due to their weak and complex magnetic field structure, that are not able to support significant prominence mass. Typically, prominence mass loss rate increases with decreasing stellar mass. Predicting the mass loss rates of Mdwarfs Rose F.P. Waugh and Moira M. Jardine rw47@st-andrews.ac.uk Prominences can be used as ‘wind gauges’ to predict the wind M/A (mass loss rate per unit area) [1]. Prominence material is likely supplied in the same way as the wind - blowing up the field lines. . . University of St Andrews, Scotland 0. Introduction 1. Method 2. Results 2.2 Prominence mass loss rates with stellar mass 2.1 The prominence mass distribution around these stars 2.3 comparing prominence and wind mass loss rates Dipole axis is perpendicular to rotation axis Dipole axis is aligned with rotation axis * AD Leo has been shifted 1 degree right and GJ494 has been shifted 4 degrees left, as the distributions overlap. . . . .. Highly tilted dipoles support material at high latitudes More aligned dipole fields supports material at only low latitudes, but the distribution is much smoother. . . Top panel: Plotting prominence M/A against X-ray flux (Fx) as Wood 2005 [3] we find a line of best fit (blue dashed line): M/A Fx Use ZDI maps for a subset of Mdwarfs Construct coronal magnetic field assuming a potential field Find mechanical equilibria from force balance Check stability using Ferreira’s condition [2] Calculate mass loss rates, assuming all possible formation sites are filled 1.32 . . M* Visible prominence mass loss rates True prominence mass loss rates Comparing to literature wind values Stellar wind mass loss rates (M) can be diﬀicult to measure for low mass stars due to their low densities. Considering the prominence mass that would be visible, it becomes apparent that the Ms would be underestimated, though the scatter remains. . . . 3. Conclusions Most prominence mass is not visible to us Our modelling has yielded a similar relation for M/A as a function of Fx for prominences as for stellar winds. 1 2 1 2 .. . Prominence 1 will cross the stellar disc (be visible), but 2 will not. Side on view: Head on view:


Cut marks 373 NISP 7.2 %NISP Burnt bones 1110 21.6 Fracture marks 1621 31.6 Digestions 58 1.1 Non-anthropic 2 0.04 Cut marks 45 NISP 4.8 %NISP Burnt bones 463 51.3 Fracture marks 10 1.1 Digestions 2 0.2 Non-anthropic 0 0 YOUNG 10% SUBADULT 5% ADULT 85% SUBADULT ADULT 35% YOUNG 8% 57% INDET. 45.8% MIXED 3.5% DRY 25.9% FRESH 24.8% INDET. 27.4% MIXED 11.1% FRESH 61.5% Complete = 20.2% Fragmented = 79.8% Non-anthropic Complete = 47.6% Fragmented = 52.4% LEPORID EXPLOITATION BY IBERIAN MEDITERRANEAN GRAVETTIAN GROUPS INSIGHTS FROM COVA DE LES CENDRES (ALICANTE, SPAIN) Abel Martínez, Cristina Real, Valentín Villaverde Dept. Prehistoria, Arqueología e Historia Antigua, Universidad de Valencia COVA DE LES CENDRES GRAVETTIAN LEVELS LEVEL XVIA CONCLUSIONS FURTHER STEPS ... ANATOMY OBJECTIVES AGE-AT-DEATH FRACTURES MODIFICATIONS ANATOMY AGE-AT-DEATH NISP = 5150 MNI= 80 NISP = 903 MNI= 12 FRACTURES MODIFICATIONS LEVEL XVIB The Gravettian human occupation at Cova de les Cendres has been key to understand the consolidation of human settlement in the Iberian Mediterranean region. Gravettian human diet in the area is based on medium sized ungulates (mainly red deer or Iberian ibex), but also on large sized ungulates, carnivores and small prey. Nevertheless, small prey such as leporids were the most represented specie. General faunal data from level XVIA was published in Villaverde et al. (2019), and rabbit data from level XVIA was published in Pérez Ripoll (2005) and Sanchis et al. (2016). However, these papers are focused only on a sample. The analysis of the whole assemblage still in progress. Karstic cave located in Alicante (Spain) at 60 m.a.s.l. Excavated area: 22 m² STRATIGRAPHIC LEVELS: XVID, XVIC (Aurignacian); XV, XVIB, XVIA (Gravettian); XIV, XIII (Solutrean); XII, XI, IX (Magdalenian) Cendres and other Gravettian sites. The purchase of the two samples allows us to conclude that both have an anthropic origin, although some non-human marks of level XVIA. The transport is complete as would be expected from their size and as shown by the anatomical representation. However, there are also significant differences. In level XVIA, adults predominate, whereas in XVIB, sub-adults are the most represented. Furthermore, fresh fractures are much more numerous in XVIA. The percentage of burnt bones is higher in XVIB, while the number of cut and fracture marks is greater in XVIA. These differences may be attributed to variations in hunting (method, season) and consumption patterns, perhaps related to differences in the occupation system of the site. However, it should be noted that the sample from level XVIB is relatively smaller in size, and that the results require further verification through additional study. Proyect "La dieta de neandertales y sapiens. Evaluación experimental del procesado de los conejos y su calidad alimenticia (LEO23-2-9659)", supported by a 2023 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation. The BBVA Foundation accepts no responsibility for the opinions, statements and contents included in the project and/or the results thereof, which are entirely the responsibility of the authors. Pérez Ripoll, M. 2005. Caracterización de las fracturas antrópicas y sus tipologías en huesos de conejo procedentes de los niveles gravetienses de la Cova de les Cendres (Alicante), Munibe 57, 239-254. Sanchis, A. et al. 2016. El conejo en la subsistencia humana del Paleolítico superior inicial en la zona central del Mediterráneo ibérico, What bones tell us/ El que ens expliquen els ossos (L. Lloveras, C. Rissech, J. Nadal, J. M. Fullola, coords.), Barcelona, 145-156. Villaverde, V. et al. 2019. The early Upper Palaeolithic of Cova de les Cendres (Alicante, Spain), Quat. Int. 515, 92-124. - The study sample will be expanded in order to ascertain the representativeness of the results at each level. - A comparison will be made between these taphonomic results and the data from the experimentation on rabbit being carried ou


AUTOMATIC SPRAY DESINFECTANT CHICKEN WITH ANDROID BASED ON ARDUINO UNO 1. Background The role of technology facilitates human work in solving every problem. 2. Chicken farms are found various problems both from the object and its management 3. To keep the chicken coop clean and sterile from disease 4. Automatic spray disinfecting chicken coop with Android based Arduino Uno. 2. Aim The aim of making the automatic control system spray disinfectant chicken coop with an Android-based Arduino Uno is to make it easier and give a sense of security to officers when spraying disinfecting chicken coops. Reference Bill, R. G. J., Ferron, R., Braga, A., Bill Jr., R. G., Ferron, R., Braga, A., Braga, A. (2000). Water mist (fine spray) fire protection in light hazard occupancies. Journal of Fire Protection Engineering, 10(3), 1 22. NA. (1997). LED Application Notes - LED Basics. Retrieved from Meng, W., & Jin, W. (2017). The optimal design of wheeled robot tracking system. In 2016 2nd IEEE International Conference on Computer and Communications, ICCC 2016 - Proceedings (pp. 900 5. Conclusions From each stage that has been done in testing can be concluded. 1. By using hardware in the form of a microcontroller circuit (Arduino Uno) and Android application to control disinfecting spray automatically and can work at a maximum distance of 10 meters through Bluetooth communication. 2. Testing is done directly using the Bluetooth module HC-05 as a communication media for Android smartphones with Arduino Uno and a 12 VDC diaphragm pump, 80 psi as a disinfecting spray, while the spray drive motor using a DC 5V motor works with the program that has been created, so that can simplify and provide security to farmers when spraying disinfectants on chicken coops. 4. Testing Results The table. Automatic Testing Results for Disinfecting Spray Chicken Coop With Android Based on Arduino Uno No. Distance Motor rotates (Yes/No) LED Lamp (On/Off) Diaphragm pump spinning (Yes/No) Average Results Testing Right Left 1. 2 1 1 1 1 2. 4 1 1 1 1 3. 6 1 1 1 1 4. 8 1 1 1 1 5. 10 1 1 1 1 From the data table, the results of automated testing spray disinfectant chicken coops with Arduino UNO-based Android. The whole series of automatic spray disinfectant chicken coops with Arduino UNO-based Android can work correctly according to the program created 3. System Development The process of working on the system in processing data sent by smartphones and data received by Arduino uno microcontrollers via Bluetooth. a) Android smartphone gives commands to HC-05 sending data to Arduino Uno. b) Arduino receives and processes data received from HC-05 to run the disinfecting spray automation system that has been programmed in the arduino sketch. c) Arduino sends a low signal to the low trigger relay module. d) The low trigger relay module receives a command to run the pump motor disinfectant. e) The pump motor is disinfected and works according to the time specified in the programming. f) Arduino microcontroller gives a signal / command to the L298N motor drive as a rotary DC motor drive g) DC motor rotate right / left alternately.


Design details for an apron slab and drainage For further information visit: http://wedc-knowledge.lboro.ac.uk/ A A Connecting rod 480-500 Spout aligned to apron centerline Circular shaped apron slab Flat stone set into apron to prevent erosion India MkII handpump Borehole casing pipe Slab foundation 2% slope 2% slope Apron diameter 1700 (min) 2% slope 2% slope Excavated earth heaped to protect soakpit from surface water 150 All dimensions shown in millimeters 1000 150 Spout aligned to apron centerline Operators platform Radius Soakpit Soakpit filled with large stones with smaller stones on top (An alternative is a pit lined with bricks and covered with a concrete slab) Drain at least 6000 in length with good slope (2% min) and stone foundation with surface plaster of cement mortar 2% slope 150 150 150 100 100 2000 150 Drainage channel 6000 (min) 250 250 250 2000 400 1000 400 250 Section on A-A © WEDC Developing knowledge and capacity in water and sanitation Poster 58


First results of the virome of Scaphoideus titanus, Frankliniella occidentalis and Thrips tabaci Abbà, Simona1; Chiapello, Marco1; Ottati, Sara1; Galetto, Luciana1; Tavella, Luciana2; Turina, Massimo1; Marzachì, Cristina1 1Institute for Sustainable Plant Protection of the National Research Council of Italy, IPSP-CNR, Turin, Italy 2Dipartimento di Scienze Agrarie, Forestali ed Alimentari DISAFA, Università degli Studi di Torino, Grugliasco, Italy Corresponding author: simona.abba@ipsp.cnr.it IT FR CH HU 2 3 2 1 3 1 2 2 Gland Saint−Nexans Corgoloin Gomba Asti Verona Togliano Vacri Iflaviridae Parvoviridae unclassified USA 6 1 0 0 % 33% 17% 33% 17% Muncie (IL) Virus families Peribunyaviridae Nodaviridae unclassified Reoviridae Number of different virus species Virus families Number of different virus species Native to North America, it was introduced by accident to Europe 8 sampling sites on 5 plant species: pepper, strawberry, watermelon, tomato, Dimorphoteca 4 sampling sites on 2 plant species: leek, onion Viroplant has received funding from the European Union’s Horizon H2020 Research and Innovation Programme. Grant Agreement N. 773567 69% 31% 25% 6% Sampled insects: 32 Gland (CH) 44% 56% 8% 8% 40% Sampled insects: 18 Saint−Nexans (FR) 20% 80% 49% 31% Sampled insects: 20 Corgoloin (FR) 42% 58% 58% Sampled insects: 38 Gomba (CH) 61% 39% 15% 5% 19% Sampled insects: 36 Asti (IT) 67% 33% 33% Sampled insects: 12 Verona (IT) 78% 22% 13% 9% Sampled insects: 46 Togliano (IT) 50% 50% 33% 17% Sampled insects: 12 Vacri (IT) Muncie(Illinois) Sampled insects: 3 % insects with viruses % insects with no viruses % insects with viruses Virus prevalence Sampling sites and viral species Sampling sites and viral species Scaphoideus titanus virome Thrips tabaci (OT) and Frankliniella occidentalis (WFT) viromes Flaviviridae Iflaviridae Lispiviridae Mesoniviridae Parvoviridae Peribunyaviridae Reoviridae Rhabdoviridae unclassified Number of different virus species A drastic reduction in the use of chemicals and pesticides in agriculture requires new sustainable biocontrol strategies to restrain pathogen multiplication and virulence in plants. VIROPLANT is a EU-funded research project whose primary objective is to propose viruses as potential biocontrol agents of some speciﬁc plant diseases spread in Europe. RNAseq was applied to characterize the virosphere of Scaphoideus titanus (Fam. Cicalinae), vector of Flavescence dorée phytoplasma in Europe, Frankliniella occidentalis (Fam. Thripidae) and Thrips tabaci (Fam. Thripidae), vectors of Tomato spotted wilt virus and Onion yellow spot virus, respectively. The identiﬁed viral species were all conﬁrmed by RT-PCR. All insects were collected on Vitis Vinifera. The three viral species identiﬁed in Europe are similar to: Psammotettix alienus iﬂavirus 1 (41.6% identity), Spissistilus festinus virus 1 (54.0% identity) and Diatraea saccharalis densovirus (35.1% identity). Virus families Insects were collected on diﬀerent plant species, which are represented alongside the sampling sites OT WFT Work Package 4 tasks are: i) analyse viromes of exemplary agronomical insect vectors and pests; ii) test the pathogenic potential of some newly found viruses. IT


Isabel Rebollido1, Marshall Perrin1, Christine Chen1, Chris Stark2, Paul Kalas3, Laurent Pueyo1, Julien Girard1 1Space Telescope Science Institute, Baltimore, MD, USA, 2NASA Goddard Space Flight Center, Greenbelt, MD, USA 3Astronomy Department, University of California, Berkeley, CA, USA irebollido@stsci.edu Why β Pic? The star, β Pic, (A6V with an estimated age ~20 Myr) is nearby (~19 pc) and bright (V=3.8 mag). High angular resolution scattered light and thermal emission images have revealed a spectacular edge-on disk including a main belt (diameter ~1800 au) and an inner belt (6.4 au) . β Pic also hosts two Jovian-mass planets, β Pic b and β Pic c, with semi-major axes of 9 and 2.8 au respectively. Finally, we have had evidence of dynamical activity in the system for over 30 years, when exocomets were first discovered around β Pic. Observations with HST What do we see in the data? Takeaway message! During the past 25 years, HST has visited beta Pic repeatedly to image its archetypal disk in scattered light. These observations span visible (STIS, ACS) to near-infrared light (NICMOS, WFC3). We present here unpublished WFC3 F160W observations for the first time and an improved reduction of F110W. Although many of the individual observations have been analyzed in detail, the complete set of scattered light images has never been studied self- consistently. We plan to analyze these observations in conjunction with high angular resolution thermal emission images and planned JWST Cycle 1 GTO observations (PID 1411), to study the dust spatial distribution, shape and composition in detail. • Both the SW (a) and the NE (b) sides of the disk have a blue color at distances great than 50 au. • The Disk Flux/Stellar Flux (c) and the Disk Flux/Stellar Flux time the stellar offset squared (d) indicate the presence of a density enhancement at ~100 au. • The disk is asymmetric (e) with the SW side being brighter than the NE. The disk appears more asymmetric at longer wavelengths (~100) au and more asymmetric at shorter wavelengths (~85 au). • We have analyzed HST β Pic images from 3 different instruments: ACS, STIS and WFC3. • We find a density enhancement in the disk at 50-100 au (d). • We find that the asymmetry of the disk (e) is more pronounced and further from the star in the WFC3 data when compared to ACS and STIS. • We plan to self-consistently analyze the scattered light and thermal emission from the β Pic disk to better constrain the overall disk geometry and the properties of the constituent grains (e.g. size, composition). JWST Cycle 1 science observations coming soon, so stay tuned! Images of β Pic observations used in this analysis. Title indicates the instrument and filter (ACS, WFC), or instrument and observation program (STIS). The central wavelength of the filters is shown in the upper right, and the date in the upper left. Images are scaled to show comparable fields of view. a b c d e I have another poster! We detected CO gas in a young debris disk @102.201 IMAGES OF THE β PIC DISK WITH HST RADIAL PROFILES OF THE DISK Some References: Larwood & Kalas, 2001; Okamoto 2004;Lagrange+2008; Apai+2015; Ballering+2016; Lagrange+2019 01-Oct-2003 01-Oct-2003 01-Oct-2003 17-Sep-1997 06-Mar-2012 23-Sep-2013 21-Nov-2009 21-Nov-2009 We are for the first time gathering all Hubble coronagraphy of the famous β Pic debris disk for a joint analysis of the disk as seen in multiple wavelengths and over time


Institute of Environmental Physics Im Neuenheimer Feld 229, D-69120 Heidelberg www.iup.uni-heidelberg.de Heidelberg Collaboratory for Image Processing Speyerer Straße 4, D-69115 Heidelberg hci.iwr.uni-heidelberg.de [1] Cox, C. and Munk, W. (1954). Measurements of the Roughness of the Sea Surface from Photographs of the Sun‘s Glitter, J. Opt. Soc. Am. 44(11), pp. 838-850. [2] Kiefhaber, D. (2011). Improved optical instrument for the measurement of water wave statistics in the field, In Komori et al. (eds.): Gas Transfer at Water Surfaces, Kyoto Univ. Press, pp. 358-367 [3] Kiefhaber, D. (2014). Optical measurement of short wind waves – from the laboratory to the field, Dissertation, Universität Heidelberg, Germany [4] Caulliez, G. (2011). Unpublished data from laser slope gauge measurements in the large Marseille Pytheas wind-wave facility, kindly provided by personal communication References:Correspondingauthor: Daniel Kiefhaberdaniel.kiefhaber@iup.uni-heidelberg.deWind wave statistics from specular reflectionsWind wave statistics from specular reflections D. Kiefhaber1), C.J. Zappa2), and B. Jähne1) 1) Institute of Environmental Physics and Heidelberg Collaboratory for Image Processing, Univ. Heidelberg, Germany 2) Lamont-Doherty Earth Observatory, Columbia University, Palisades, NYReflection-based wave measurementsSlope measurementcameras(stereo)FOV:4.2°x3.4°cameraFOV:20°x15°LEDlightsources •brightness of individual reflections is linked to small scale surface curvature •Curvature is very sensitive to changes in environmental conditions •Left: Ship is entering area with surface slick at t = 150 s, curvature decreases, reflection brightness increases •Below: Reflection brightness also has a strong dependence on wind speedCurvature measurement clean rough surface slick smooth surfaceStereo image pair with reflections of the instrument‘s light sources (see right)Heightstereo disparitySlopereflection distributionCurvaturereflection brightnessConclusion and Outlook •New reflection-based instrument capable of measuring slope probability distribution and slick sensitive curvature parameters •Easy to deploy and operate •Robust measurements, day and night •Provides important information on wave field in air-sea interaction experiments •Slope measurement: Like Cox & Munk (CM) sun glitter measurements [1], but with artificial light source! •Area of water surface is illuminated, but reflections are only visible when surface normal points to camera/light source •Surface slope at points of reflection can be computed from position in image uand focal length of lens f: tan α= u/f •Average distribution of reflections = slopeprobabilitydensityfunction! [2]Mean square slope in the field •Fit Gram-Charliermodel to data; similar to CM (left) extract mean square slope σ² •Lab comparison to laser slope gauge [4]: works fine at lower wind speeds •high wind speeds and very limited fetch: Gram-Charliermodel not adequate, leading to an overestimation of mss OSM 2012 / [3]Reflection brightness decreases strongly with wind speed, large variability due to surfactants.Data from Meteor M91, SOLAS-Peru cruise to the upwelling regions off the Peruvian coast. Example reflection images, grayscale inverted for visibility Mean square slope measurements from Peru experiment. Large variability of conditions due to changing presence of surfactants. Data points mostly lie between the CM parameterizations for clean water (solid) and slick (dashed).PDF? •4 week experiment off the coast of Peru •Ship motion correction applied to wave data •Moderate wind speeds, changing presence of surfactants •Changes in surface roughness possible on small spatial scales, < 100 m •Surfactants will likely have big impact on air-sea gas exchange ratesGram-Charliermodel not adequate for high wind speed, very limited fetchvery good agreement for lower wind speedsMeasured 2D slope probability distributionCrosswind profile of 2D slope pdf (along white line)Laboratory validationPDF measu


Objectives The “Pilot Line for Micro-Transfer-Printing of Functional Components on Wafer Level” project (MICROPRINCE) is focused on creation of a pilot line for micro-transfer-print ing (µTP) of functional components like processed III/V devices, optical filters, and special sensors. Several EU and national research activities demonstrated successfully the feasibility of µTP technology in a scientific and laboratory environment. The MI CROPRINCE consortia has the goal to set up the first worldwide open access foundry pilot for heterogeneous integration by µTP and to demonstrate its capability on five defined target application scenarios:  µTP for special magnetic sensors,  µTP of optical filters on photosensitive sensors,  µTP for LED devices and,  µTP for photonic-based life science applications. Relevance and Impact The consortia consisting of 12 industrial and scientific partners from four different countries combine their expertise along the value chain from materials and equipment, technology and semiconductor processing, integrated circuit and system design, test and application to create a new industrial smart system manufacturing capability in Europe. MICROPRINCE is an excellent project to bridge the gap between research activities and industrial exploitation for innovative smart system integration for future key applications and markets in different sectors. This contributes significantly to the continued development of a strong and competitive electronic component and systems (ECS) industry in the European Union. MICROPRINCE will improve the competitiveness of industrial small, medium and large enterprises and strengthen the position of research institutes. This will influence the long- and medium-term position in key markets leading to economic and employment growth in the European Union. The MICROPRINCE pilot line is acting as a regional and nationwide competence cluster for a novel technology with European dimensions for heterogeneous system integration and supports the ECS industry to reach leadership in key technologies. Project Coordinator Sebastian Wicht Institution X-FAB MEMS FOUNDRY GMBH Email sebastian.wicht@xfab.com Website www.microprince.eu Start Duration 1-4-2017 36 months Total investment €M 14.5 Participating organisations 12 Number of countries 4 Technical Innovation The working principle of the micro-transfer-printing technology is to use a micro- structured elastomer stamp to transfer microscale functional components from their native substrates (e.g. III/V materials) onto non-native substrates (e.g. silicon wafers). The lateral dimensions of the functional components can range from a few microns to a few hundreds of microns with thicknesses of only a few microns. A post- processing is required to electrically connect the printed components with the silicon wafer underneath. This Micro-Transfer-Printing technology enables cost-effective combination of various materials by a massive parallelization reducing the processing time and production costs. Chiplet test designs (100 x 100 um) and confocal microscopy image of release-etched chiplets. Precise device transfer: from dense to dispersed arrays Printed optical filter on top of a silicon photodiode. Printed LED with gold pads on source wafer for wire bonding. MICROPRINCE Micro-Transfer-Printing of Functional Components on Wafer Level Germany X-FAB MEMS FOUNDRY GMBH X-FAB SEMICONDUCTOR FOUNDRIES AG MELEXIS GMBH OPTICS BALZERS JENA GMBH FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DRESDEN UNIVERSITY OF TECHNOLOGY Switzerland MELEXIS TECHNOLOGIES SA Belgium MELEXIS TECHNOLOGIES MELEXIS NV IMEC Ireland X-CELEPRINT LTD. UCC-TYNDALL


Schools: The postdoc on a genomic research project wants to involve local schools in their research project by holding a tournament for the best solution to one of the project’s research questions. They will have to organise the competition themselves, using time allocated to the research project. They feel it will promote the project in the community and make school children more interested in science. 1. What challenges will this postdoc face to make this a reality? 2. What other benefits could this activity have? 3. Do you think these kind of activities area good use of researchers’ time? Data: Jane has done several experiments which have had negative results and do not help progress her overall project further. However, she feels the results, protocol, and data are still interesting. She does not want to just shelve the work but she is not sure what to do with it. A friend says she should keep it private in case she can use it for publications later. 1. Do you think the friend is right? 2. Is there another solution that is more ‘open’? What else could be done with the data? 3. Would you like to see more negative results published? Why/why not? 4. Would you like to have access to other researchers’ protocols and data? Publishing: John has been trying to publish some exciting results from his work. However, one journal has rejected the paper and another has not gotten back to him. He hears that another lab is also preparing to publish findings in a similar area. Another researcher suggests that he publish the paper as a preprint so that it would be out first, but his PI is a bit unsure if this is a good idea. 1. Do you think he should use preprints? 2. What are the advantages or disadvantages of this approach? 3. Have you ever used preprints? What do you think about them?


A multi-robot platform to study the collective adaptive mechanisms in mixed societies F. Bonnet1, A. Gribovskiy1, L. Cazenille2, Y. Chemtob2, J. Halloy2 and F. Mondada1 1 Laboratory of Robotic Systems, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 2 Laboratory of Tomorrows Energies, Université Paris Diderot, Paris, France Introduction This work was supported by the EU-ICT project ASSISIbf, No. 601074. AMAM2017 Framework Adaptation Multi-level control Future work Social animals are one of the most fascinating example of collective adaptive systems, for which complex collective behaviors can arise from social interaction that leads to self-organization of the group. In the past few years, we designed a system to investigate the fish collective behaviors, by having robotic agents inserted among the fish societies. • Different levels of controllers have been implemented in order to automatically control the robots so that they can reproduce the fish collective behavior, and also adapt to it. • A software running in a computer retrieves the position of the agents in real-time using visual tracking • Models of zebrafish shoaling based on the vision of zebrafish are implemented to generate fish-like trajectories for the mobile robots. • Control commands are then sent to the robots so that they reach these trajectories, using specific low-level controllers that mimic the locomotion of the fish. • Thanks to the framework set in place, the study of collective adaptive behavior can be investigated with a mixed group composed of several robots and animals. • Evolutionary algorithms and optimization methods can be used to produce appropriate decentralized controllers for the robotic agents, that adapt in real-time in experiments with mixed groups of animal and robots • This allows the robots to better adapt to the animals and better integrate fish shoals. The system designed allows the collective adaptation of behaviors for two different societies, an artificial one composed of robotic agents, and a group of animals. Thanks to the adaptive mechanisms, some parameters of the robots’ controllers can be automatically adapt according to the animals, which offers perspectives for learning more on the adaptive mechanisms in social animals. • Wheeled mobile robots are moving underneath a tank and steer fish-lures inside the tank using magnets • The lures are equipped with an actuated tail that can beat with different amplitudes and frequencies, so that they can send signals that are relevant for zebrafish social behaviors • The robots are controlled in a closed-loop using visual tracking, that retrieves the individual positions of the robots as well as the positions of the fish in real-time. • The wheeled mobile robots are continuously powered so that we can study the adaptive mechanisms of the agents during long duration experiments.


Martin Šefl1 ,2, Václav Štěpán3,2, Kateřina Pachnerová Brabcová4,2, Iva Ambrožová2, Ondřej Ploc2, Mathieu Karamitros3, Sébastien Incerti3, Marie Davídková1 ,2 1 Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Prague, Czech Republic. 2 Department of Radiation Dosimetry, Nuclear Physics Institute of the ASCR, Prague, Czech Republic. 3 Université Bordeaux, CNRS/IN2P3, Centre d’Etudes Nucléaires de Bordeaux Gradignan, CENBG, Gradignan, France. 4 Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden. Calculation of solid-state track-etched detectors response in 290 MeV/u and 400 MeV/u C-1 2 ion beams using Geant4 Abstract Solid-state track-etched detectors (TED) can be applied as linear energy transfer (LET) spectrometers of charged particles. Monte Carlo simulations are helpful to identify particle types in the LET spectra and estimate their importance outside the detection range of TEDs. We have applied the Geant4 Monte Carlo simulation toolkit version 9.6p01 [1 ,2] to reproduce the beamline geometry [3] and experimental setup used for the measurements of LET spectra of 290 MeV/u and 400 MeV/u carbon ion beams at Heavy Ion Medical Accelerator in Chiba, Japan. The spectra were measured with track-etched detector TD1 (Japan Fukuvi Chemical Industry Co. Ltd), which is under our evaluation conditions sensitive to charged particles of LET between 9.46 and 500 keV/µm. The dose and LET spectra of the beam attenuated by several thicknesses of PMMA filters were calculated in water and compared with the experimental data. Calculations and measurements [4, 5] were in a good agreement within the sensitivity range of the detectors. Track etched detectors Heavily ionizing particles cause damage in the track etched detector (TED) material―a latent track. The latent track can be developed by etching in NaOH (70°C). The etched tracks are visible under an optical microscope (Figure 1 ). TED can work as spectrometers of LET. TED were exposed with C-1 2 beam 290 and 400 MeV/u in HIMAC-BIO room in Japan. TEDs do not detect particles with LET below the certain threshold (9.46 keV/µm for the TD1 by Japan Fukuvi Chemical Industry Co. Ltd). Methods The geometry description of the HIMAC-BIO beamline and the experimental set-up was based on on-site measurements. The upper view of the geometry can be seen in the Figures 2a, b, c. The beam was attenuated with the given combination of the Binary PMMA filters. The particles were scored inside a 0.1 mm thick layer. TED were calibrated to unrestricted LET in water, hence water was assigned to the detector volume TD1 . The LET of each particle was calculated as the fraction of the total energy loss and the total track length in the scoring volume. Electrons are not included in the LET spectra, since TED do not detect electrons. We used Geant4 version 9.6p01 , physics list FTF_BIC 2.0 and production threshold was set to 5 µm. Results The spectra of unrestricted LET in water behind PMMA shielding of various thickness were calculated using 2x1 05 primary C-1 2 ions and depth dose distributions in water phantom were calculated with 1 05 primary particles. Acknowledgements The work was supported by the Ministry of Education, Youth and Sports of the Czech Republic project n. LG1 3031 . The access to computing and storage facilities owned by parties and projects contributing to the National Grid Infrastructure MetaCentrum, provided under the programme “Projects of Large Infrastructure for Research, Development, and Innovations” (LM201 0005) is highly appreciated. Thanks belongs to the Czech Technical University and Nuclear Physics Institute of the Academy of Sciences of the Czech Republic for funding the attendance at this workshop. We thank to HIMAC staff for data from the reference measurements. References [1 ] J. Allison et al. IEEE Transactions on Nuclear Science, 53 (2006) 270–278. [2] S. Agostinelli et al. Nuclear Instruments and Methods in P


Motivation Inconsistent Flux in Different Sectors Conclusion TESS CROWDSAP Errors from White Dwarf Observations Pipeline vs Estimated CROWDSAP The graph compares pipeline CROWDSAP values to our estimates for white dwarf stars. We obtain our CROWDSAP estimates by recalibrating the light curves to achieve average fluxes that match the estimated TESS magnitudes from the TESS Input Catalog (TIC) [3]. Since white dwarfs should be constant in brightness on average, the estimates based on the TIC for these stars should be reliable (perhaps not for any contaminant stars). Nikoo Hosseininezhad1; Keaton J. Bell1; Swan Yi Htet1; Isabel L. Colman2 1 Queens College and the Graduate Center, City University of New York, New York, NY 2 American Museum of Natural History, New York, NY CROWDSAP is a metric within the TESS analysis pipeline, the fraction of light in the aperture estimated to come from the targeted star. This study specifically targets the TESS light curves of White Dwarfs observed across various sectors, with the goal of evaluating the uncertainties associated with CROWDSAP values. White dwarfs, characterized by their stable luminosity [1], theoretically should display uniform flux readings across observational sectors. TESS observations of WDs offer a unique opportunity to assess CROWDSAP errors. CROWDSAP inaccuracies will cause systematic errors in critical measurements such as transit depth and signal amplitude. The graph shows the flux measured by TESS in different sectors for WD 1856+534 (TIC 267574918, average CROWDSAP = 0.038) that was first discovered by [2] to have a giant plant transiting it. The average flux measured for this white dwarf is inconsistent in different sectors. The actual flux should be constant, so these differences represent errors in calibration of the TESS light curves. [1] Hermes, J.J., Gänsicke, B.T., Gentile Fusillo, N.P., et al. 2017, MNRAS, 468, 1946 [2] Vanderburg, A., Rappaport, S. A., Xu, S., et al. 2020, Nature, 585, 363 [3] Stassun, K.G., Oelkers, R.J., Paegert, M., et al. 2019, AJ, 158, 138 The differences between the pipeline and estimated CROWDSAP values give a sense of uncertainty of light curve calibrations. This is part of an ongoing effort to characterize sources on uncertainty in TESS data which includes modeling the distribution of flux from different sources in the TESS pixel data.


H5N1 Antibodies and Antigens for Research Applications Creative Diagnostics, a leading manufacturer and supplier of antibodies, antigens and assay kits, is excited to announce the launch of its new line of H5N1 Antibodies and Antigens to support cutting-edge research on this highly pathogenic influenza A virus subtype. These innovative products offer researchers and scientists invaluable tools for studying and combating the H5N1 influenza virus. Influenza A virus is a genus of virus in the family Orthomyxoviridae and causes influenza in birds and some mammals. Influenza A virus strains of all subtypes have been isolated from wild birds, but disease is rare. Some isolated influenza A viruses cause severe disease in poultry and, in rare cases, in humans. Sometimes the virus is transmitted from wild waterfowl to poultry, which can lead to outbreaks or cause human influenza pandemics. H5N1 is a subtype of influenza A virus and belongs to the genus Alpha influenza virus in the family Orthomyxoviridae. The genome of this RNA virus is segmented and consists of eight negative-sense single-stranded RNAs, abbreviated as PB2, PB1, PA, HA, NP, NA, MP, and NS. The major glycoproteins on the surface of the virus are hemagglutinin (H) and neuraminidase (N). H5N1 refers to the fact that the virus has a type 5 hemagglutinin protein and a type 1 neuraminidase protein. These proteins are antigenic when the virus infects host cells and are the primary targets of antibodies and antiviral drugs. Highly pathogenic avian influenza H5N1 viruses were first detected in domesticated waterfowl in southern China in 1996. Since 2020-2021, H5N1 2.3.4.4b clade viruses have become widespread in wild birds worldwide, leading to outbreaks in poultry and other animals. In the spring of 2024, H5N1 2.3.4.4b clade viruses have also been detected in milk samples from cows and in raw milk in several states in the United States, causing significant global concern due to their serious impact on poultry and wildlife populations and potential risk to human health. Influenza A viruses contain multiple subtypes and strains that frequently undergo genetic drift and transformation, posing a threat to human and animal health and life worldwide. Creative Diagnostics offers a wide range of high-quality antibody and antigen products related to the H5N1 influenza virus that are validated for use in a variety of assays, including Inactivated IAV H5N1 Native Antigens, Recombinant IAV H5N1 Antigens, and IAV H5N1 Antibodies. Creative Diagnostics is committed to providing researchers with the tools they need to drive scientific discovery. By offering a comprehensive portfolio of H5N1 Antibodies and Antigens, the company is supporting the global effort to develop effective strategies for preventing and treating H5N1 infections. To learn more about these antibodies and other research tools, please visit


Introduction Web Portal Digital Public Archaeology References The ArchaeoTrail App Opening a window into the past Luise Loges1, Stephanie Döpper2, Matthias Ludwig3, Deng-Xin Ken Oehler3, Iwan Gurjanow3 1 University of Glasgow, School of Humanities, Department of Archaeology 2 Goethe University Frankfurt, Institute for Archaeological Sciences 3 Goethe University Frankfurt, Institute for Mathematics and Computer Science Education www.archaeotrail.org @ArchaeoTrail Archaeological sites offer valuable insights into the past. Wi- thout good presentation, however, it is difficult to communicate this knowledge to the general public. The newly developed ArchaeoTrail App does just this and offers the opportunity for visitors to discover the archaeologi- cal sites on their own. This is realized by a two-folded system consisting of a web portal and the ArchaeoTrail app for smartphones. The web portal (www.archaeotrail.org) provides archaeolo- gists and other people responsible for archaeological sites with the technical toolkit to create"trails", i.e., informative tours of their site for visitors. For each trail, several stations at the archaeological site can be generated and filled with infor- mational texts, images as well as short audio and video files and different types of quizzes, especially targeted at younger visitors. Each station is geo-referenced simply by clicking on the correct position at the map. In a second step, these sta- tions are joined in a trail and a suggested path can be crea- ted. Translations of the trail in various languages can be added. To make the trail publicly available, it has to undergo a review process by a designated reviewer board. This is to assure that only trails containing relevant archaeological in- formation are uploaded and that they do not violate a general code of conduct. Select a trail Check what trails are available in your region of interest Follow the trail using GPS Get information for each station The goals of the ArchaeoTrail project are diverse and rely on different levels of engagement of members of the public. On the one hand, it is a classical outreach project, disseminating information to a larger audience, i.e. visitors of the archaeological sites featured in the app, by means of a largely one-way communication (Bollwerk 2015). This nevertheless, contributes to a general awareness of the economic, social and political importance of cultural heritage and thus generates an interest and motivation for its protection (Smith 2006). On the other hand, it has a participatory aspect when the public is involved in creating the trails, e.g., through public discussions with different stakeholders to encourage dialogue and implement their say on the content of the trails. Additionally, online feedback forms at the end of some trails help to further ensure that the interpretative content of the trails draws from multiple perspectives instead of relying on a single authoritative explanation (Bollwerk 2015: 228). Regarding the web portal, the ArchaeoTrail project provides a collaborative form of Digital Public Archaeology in a way that was labelled by Bonacchi (2017: 69) as “hosted participation”. An institution (here: the ArchaeoTrail project) provides space, expertise and infra- structure to facilitate a project undertaken by members of the public, i.e., the creation of a trail. As this involves volunteer work for setting up a trail, the question for the benefits of the volunteers involved is pressing (Walker 2014: 87). At best, such projects allow participants to develop their own skills, encourage self-realization and creativity, stimulate reflection, create a sense of be- longing and community cohesion, offer participants the opportunity to have an impact on archaeological research and make a meaningful contribution to the common good, and generally enrich their lives (Merriman 2004: 7, Owens 2013). It must be added, however, that it is expected that most contributors to trails will be t


Calculate properties of molecules using computers Goal: predict how molecules react • Where are the electrons in a molecule? • How much energy is needed to break bonds? • How do molecules move? • How do molecules interact with light? CyberTraining: Implementation: Medium: ChemCompute: Computational Chemistry for Undergraduate Education and Research NSF Award #2417553 Kristina Closser, Mark Perri Department of Chemistry and Biochemistry, California State University Fresno; Department of Chemistry, Sonoma State University NSF Cybertraining Award #2417553 NSF ACCESS Allocation TG-CDA170003 SSU RSCAP (2011 Equipment and 2018 Summer) SSU SST Faculty Development Funds Educational Experience Enhancement Award Science & Technology Innovation and Strategic Priorities Science Gateway Community Institute Koret Foundation Abstract Acknowledgements References ChemCompute (chemcompute.org) offers free cloud-based computational resources to undergraduate chemistry students allowing computational experiments in quantum mechanics and molecular dynamics, and offers Jupyter Notebook-based data analysis. Since 2014 over 650,000 computational chemistry jobs have been performed using NSF-provided supercomputer resources through ChemCompute. This work improves website accessibility, expands capabilities for research, develops new curriculum, and creates a faculty community. Course-based undergraduate research experiences are developed where undergraduate students conduct novel research on computational chemistry projects or projects combining experiment and theory. Data is collected assessing student engagement and confidence in using computers to solve chemical problems. Faculty workshops will contribute to the development of new teaching materials and the creation of a user community. Dissemination of website capabilities through workshops and partner organizations, focusing on minority serving institutions, exposes more students to computational chemistry research. Through this project, students develop computational skills valued in graduate studies and in the workforce. Supercomputer Resources Train Faculty to use ChemCompute Web Interface to Free Software Provides Accessibility to Undergraduates • Free • Run from any computer • No installation required • Quantum chemistry (GAMESS and Psi4) • Molecular Mechanics (Tinker, NAMD, OpenMM) • Jupyter simulations and notebooks Barriers to Computational Chemistry 1. High price of computational chemistry packages 2. Hardware to run computations 3. Expertise to setup and maintain hardware and software Spartan ($1,200 ea) GAMESS (Free) 2024 - 2025 Allocation Expanse (San Diego) 165,000 CPU-hours Bridges2 (Pittsburgh) 165,000 CPU-hours Jetstream2 (Indiana) 550,000 CPU-hours ACCESS = Advanced Cyberinfrastructure Coordination Ecosystem: Services and Support NSF funded collection of super computers located around the country Improve Accessibility and Site Capabilities 1. Schmidt, M. W. et. al General atomic and molecular electronic structure system. J. Comput. Chem. 1993. 2. Ponder, J.; Richards, F., TINKER molecular modeling package. J. Comput. Chem 1987. 3. Perri, M. J.; Weber, S. H., Web-Based Job Submission Interface for the GAMESS Computational Chemistry Program. J. Chem. Educ. 2014. 4. Towns, J. et al. XSEDE: accelerating scientific discovery. Computing in Science & Engineering 2014. 5. Perri, M. J.; Akinmurele, M.; Haynie, M., Chem Compute Science Gateway: An Online Computational Chemistry Tool. Using Computational Methods to Teach Chemical Principles. ACS Symposium Series 2019. ChemCompute Usage Create Resources for Education and Research 39,500 users in 2023-2024 • Ensure compliance with WCAG AA guidelines • Expand research capabilities (file organization, job customization) Develop course-based undergraduate research (CURE) materials • Train students to in computational chemistry • Stand-alone computational course and blended experimental/computational course • Distribute materials through site to o


Modelling stellar transition regions of F-G stars with advanced ionisation equilibrium Evangelia Deliporanidou and Dr. Giulio Del Zanna Department of Applied Mathematics and Theoretical Physics, University of Cambridge Abstract We employed advanced ionisation equilibrium models developed by Dufresne et al. [5], which include charge transfer and density effects to study stellar irradiances in the EUV and UV for a sample of stars. Our sample includes ε Eridani (K2 V), α Centauri A (G2 V), Procyon (F5 V), and Proxima Centauri (M5.5 Ve). We remeasured the line fluxes from STIS datasets and used O IV and O V as a density diagnostic to measure the formation pressure of ions in the transition region (TR). Our findings indicate significant improvements in modelling anomalous ions, such as Si IV, C IV and N V, from Li- and Na- like sequences, which produce the strongest lines in UV. We obtained first-time reliable estimates of some stellar chemical abundances in the TR, using a Differential Emission Measure (DEM) modelling. We also obtained significant improvements in the calculated-to-observed flux ratios. These results are compared with available photospheric abundances, demonstrating the effectiveness of our approach to look for evidence of the First Ionisation Potential (FIP) effect, in the TR of our stellar sample. Finally, we compared our results with an analysis of solar TR irradiances in the EUV. New Ion Balances We call ”anomalous” the ions of the Li- and Na-like sequences, as they are under-predicted by sig- nificant factors compared to other ions, forming at similar temperatures and densities, assuming zero density ionisation equilibrium, the standard in Astrophysics. This problem was observed on the Sun and Del Zanna et al. [2] combined EUV and UV observational data and showed for the first time that the anomalous ions are also under-predicted in stellar atmospheres. Sim and Jordan [10] developed an approximate method for ϵ Eridani, which is a K2 V dwarf star, to resolve the main discrepancies by including density and charge transfer effects. In Dufresne et al. [5], we developed advanced ionisation equilibrium models that include these effects and found significant improvements for a solar plage ob- servation in the UV. The main difference between the advanced models and the coronal approximation used in the previous CHIANTI versions [1, 3], is that the anomalous ions have increased intensities by factors of 2-5. Also, they shift the ion formation towards lower temperatures. Figure 1. Silicon ion balance at a constant electron pressure of 7×1015 cm−3 K, with charge transfer included using the Fontenla 2014 Facula model atmosphere. We also show the advanced models without charge transfer and the CHIANTI v.10.1 coronal approximation model. Dufresne et al. [5] FIP Effect Our stellar sample was chosen to investigate the First Ionisation Potential (FIP) effect [6, 8] in stellar TR. This effect, first identified in the active solar corona, is characterised by an overabundance of low-FIP elements, such as Fe, Mg, and Si compared to high-FIP elements, such as H, He and O. Many studies of stellar coronae found that the FIP and Inverse FIP (IFIP) effects are prevalent among active stars and vary with stellar activity, see the review by Seli et al. [9]. Both FIP and IFIP are explained by models from Laming [6]. Method We remeasured line fluxes from Space Telescope Imaging Spectrograph (STIS) selecting the datasets with the longer exposure time, an E140H or E140M grating within a wavelength range of 1100 < λ < 1700. We used O IV and O V as a density diagnostic and assumed a constant pressure for the ions in the stellar TR. We used a pressure of 1016 cm−3 K for ϵ Eridani, Proxima Centauri and Procyon and a pressure of 1015 cm−3 K for α Centauri A. We eventually evaluated the improvements in modelling anomalous ions and derived reliable estimates of stellar abundances via a DEM modelling. We adjusted the log DEM based on the scaling fact


> STRUCTURE ET CONTENU DE INTERVENTION DE E-APPRENTISSAGE EN ENTRETIEN MOTIVATIONNEL Une application informatique incluant deux éléments : 1) L’ALGORITHME ÉVALUATIF ALEGRO (Paradis, Cossette et Heppell, 2010) permettant de cibler à quel stade de changement et de motivation (point de jonction entre ces deux évaluations) se situe le patient à l’égard de la réduction des facteurs de risque; 2) 13 CAPSULES VIDÉO de 1 à 2 minutes mettant en vedette une infirmière praticienne spécialisée qui illustre par des jeux de rôles les interventions à appliquer en EM selon chaque point de jonction (motivation x stade de changement →Permet de fournir un soutien motivationnel adapté au stade de changement : DEVIS Pré-expérimental avant-après à groupe unique Les méthodes d’apprentissage électroniques pour la construction des compétences cliniques en entretien motivationnel : un protocole de recherche GUILLAUME FONTAINE, INF., B.SC., ÉTUDIANT M.SC. + SYLVIE COSSETTE, INF., PH.D. + MARIE-FRANCE OUIMETTE, INF., M.SC. + SONIA HEPPELL, INF., M.SC., IPSC PROBLÉMATIQUE Le soutien motivationnel offert par les infirmières lors de l’hospitalisation est essentiel à la réduction des facteurs de risque après un événement cardiaque. Toutefois, l’utilisation des techniques d’entretien motivationnel nécessitent des compétences spécifiques acquises actuellement chez un nombre limité d’infirmières via des formations longues et couteuses. Les méthodes d’apprentissage électroniques (e-apprentissage) sont en plein essor en pédagogie de la santé pour faciliter la construction de ces compétences cliniques. BUT Cette étude pilote vise à évaluer la faisabilité, l’acceptabilité et l’impact sur les compétences cliniques perçues d’une méthode d’apprentissage électronique en entretien motivationnel chez des infirmières en soins critiques cardiovasculaires. MÉTHODE Une étude pilote de faisabilité et d’acceptabilité avec devis avant-après à l’unité coronarienne (UC) de l’Institut de Cardiologie de Montréal. Le cadre théorique de l’intervention de e- learning est le Technology Acceptance Model (TAM) développé par Davis (1989) et le modèle de recherche a été conçu selon les travaux de Cheng (2012). • Cheng, Y. M. (2012). The Effects of Information Systems Quality on Nurses’ Acceptance of the Electronic Learning System. Journal of Nursing Research, 20(1), 19-30. • Cole, J. A., Smith, S. M., Hart, N., & Cupples, M. E. (2013). Do practitioners and friends support patients with coronary heart disease in lifestyle change ? A qualitative study. BMC Family Practice, 14(126). • Kala, S., Isaramalai, S. A., & Pohthong, A. (2010). Electronic learning and constructivism : A model for nursing education. Nurse Education Today, 30(1), 61-66. • Noordman, J., De Vet, E., Van Der Weijden, T., & Van Dulmen, S. (2013). Motivational interviewing within the different stages of change : An analysis of practice nurse-patient consultations aimed at promoting a healthier lifestyle. Social Science & Medicine, 87, 60-67. • Paradis, V., Cossette, S., Frasure-Smith, N., Heppell, S., & Guertin, M. C. (2010). The Efficacy of a Motivational Nursing Intervention Based on the Stages of Change on Self-care in Heart Failure Patients. Journal of Cardiovascular Nursing, 25(2), 130-141. • Söderlund, L. L., Madson, M. B., Rubak, S., & Nilsen, P. (2011). A systematic review of motivational interviewing training for general health care practitioners. Patient Education and Counseling, 84(1), 6-26. • Van der Heijden, H. (2004). User acceptance of hedonic information systems. MIS Quarterly, 28(4), 695-704. > RÉSUMÉ > PROBLÉMATIQUE ↓ des facteurs de risque chez les PATIENTS CARDIAQUES après un évènement cardiovasculaire grâce à l’entretien motivationnel : → Prévient les récidives → Améliore la qualité de vie (Söderlund et al., 2011; Cole et al., 2013; Noordman et al., 2013) Cependant, dans un contexte où les ressources financières et pédagogiques ↓ et que les formations actuelles en ENTRETIEN MOTIVATIONNEL sont caractérisé


Jorge C. S. Cardoso CITAR -‐ Portuguese Catholic University jorgecardoso@ieee.org The PuReWidgets toolkit for interac6ve public display applica6ons University of Minho School of Engineering Algoritmi Research Centre Portuguese Catholic University School of Arts Research Centre for Science and Technology of the Arts Rui José Algoritmi – University of Minho rui@dsi.uminho.pt 1. PuReWidgets toolkit PuReWidgets is a widget toolkit for web-‐based interacJve public display applicaJons that provides: • MulJple, extensible, controls; • MulJple interacJon mechanisms; • AutomaJc graphical interface generaJon; • Concurrent interacJon; • Asynchronous events; 2. Mul6ple, extensible, controls • AcJon buOon -‐ trigger an acJon in the applicaJon, e.g., play a video; • OpJon selecJon -‐ selects among a set of opJons, e.g., to vote; • Text entry -‐ sends text to the applicaJon, e.g., a comment, tag, search keyword; • Download -‐ receives a media ﬁle from the applicaJon, e.g., download poster; • Upload -‐ uploads a media ﬁle to the applicaJon, e.g., a photo to be displayed; • Check-‐in -‐ says “I’m here”. 3. Mul6ple interac6on mechanisms PuReWidgets abstracts the details of various interacJon mechanisms • SMS, Bluetooth naming, OBEX; • Rich, automaJcally generated, graphical interfaces; • QR codes. 4. Automa6c graphical interface genera6on PuReWidgets provides rich graphical interfaces for desktop and mobile devices, and also QR codes for individual widgets: Desktop & Mobile PuReWidgets generates a webpage which lists the applicaJons available in a locaJon, and provides a web interface to each applicaJon: This work is ﬁnanced by FEDER funds through the “Programa Operacional Fatores de CompeJJvidade – COMPETE” and by NaJonal Funds through the FCT – Fundação para a Ciência e Tecnologia within the project: FCOMP-‐01-‐0124-‐FEDER-‐022674 Jorge C. S. Cardoso is also funded by FCT training grant SFRH/BD/47354/2008 5. Concurrent interac6on Allows various users to interact at the same Jme, while providing applicaJons with idenJty informaJon that allows them to diﬀerenJate users. • Every input event carries a user id (if available). 6. Asynchronous events Allows applicaJons to receive input events that were generated when the applicaJon was not listening. • PuReWidgets provides a persistent input queue for each applicaJon; • ApplicaJons can request past input at any Jme. 7. Architecture QR codes PuReWidgets provides display owners the possibility of prinJng QR codes for individual widgets in use by applicaJons: I/O Infrastructure • Provides low-‐level data-‐based interacJon; • Handles data from interacJon mechanisms such as SMS, email, Bluetooth naming, etc.; • Provides a command-‐based interface to the PuReWidgets service. PuReWidgets service • Keeps informaJon about every widget; • Generates graphical interfaces for desktop, mobile, touch plaoorms; • Generates QR codes for every widget; • Generates unique reference codes for data-‐based interacJons (SMS, BT naming, OBEX, etc.). PuReWidgets library • Provides a widget-‐based interacJon abstracJon; • Provides opJonal graphical representaJons for widgets and for input feedback on the public display; • Provides client and server applicaJon models; • Hides communicaJon details with the PuReWidgets service. 8. Implementa6on PuReWidgets is implemented using Google’s App Engine plaoorm and Google’s Web Toolkit (GWT) . • The library is a GWT module that can be included in their projects; • The service is an App Engine applicaJon that exposes a REST API; • The graphical components take advantage of the standard GWT HTML widgets; • hOp://purewidgets.googlecode.com