Double-Active Membranes for a sustainable CO2 cycle DAM4CO₂ develops a novel membrane technology for the simultaneous CO₂ separation and its photocatalytic conversion to C4-C9 molecules, as renewable fuels. The project will deliver a prototype, designed using the design-build-test-learn approach, for a proof-of-concept validation that will be tested in lab-conditions. The DBTL approach is inherent in each scientific/technological WP of the project. Our objective: Partners: This project has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101115488. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Innovation Council and SMEs Executive Agency (EISMEA). Neither the European Union nor the granting authority can be held responsible for them. WP1: Coordination & Management WP2: Materials Synthesis WP3: Materials Characterization WP4: Membrane preparation & Characterization WP5: Capture with Membranes WP6: Conversion with Membranes WP7: Multiscale Modelling & Life Cycle Assessment WP8: Dissemination & Communication & Exploitation WP9: Portfolio Activities Contacts PROJECT COORDINATOR Dr. Alessio Fuoco, CNR – ITM E-mail: alessio.fuoco@cnr.it Website: www.dam4co2.eu E-mail: dam4co2@itm.cnr.it Project number: 101115488 Project title: Double-Active Membranes for a sustainable CO2 cycle Project Acronym: DAM4CO2 Granting authority: EISMEA and UKRI Start date: 01/11/2023 Duration: 36 months EU Contribution: 2 975 275.00 € UK Contribution: 823 176.00 £ • Use of non-critical raw materials at any stage of the project • Greener material and protocols for membrane production • Development of the next generation membranes for CO2 capture using advanced polymers and MOFs • Development of photocatalytic membranes using mono and bi-functional catalysts for CO2 conversion into C4-C9 molecules • Integration of the CO2 management and valorisation processes into a single device • Design of novel membrane modules CNR (IT) INSTM (IT) ME-SEP (PL) UEdin (UK) PRIMALCHIT (ES) UPV-ITQ (ES) USwan (UK) DAM4CO₂, responding to the call "EIC Pathfinder Challenge: Carbon dioxide and nitrogen management and valorisation", aims at changing the existing paradigm within separation and utilization of CO₂ by coupling membrane and catalytic technologies. https://www.instagram.com/dam4co2/ https://www.linkedin.com/company/dam4co2 https://www.youtube.com/@DAM4CO2_EIC https://twitter.com/dam4co2


Introduction • Radiation oncology physicists spend a lot of time performing and analysing pre- treatment patient-specific QA checks. Given this, we should ensure that our processes are fit for purpose. • Statistical control methods are suggested best practice for establishing, monitoring and retrospective review of QA processes and results1. These include histograms, control charts and control limits. • Our department used the installation of two new systems (the Varian Edge & Accuray Radixact) as an opportunity to reflect on and plan our future patient- specific QA processes, with control charts. Data SPC-derived control limit Modality points 2%/2mm 3%/2mm 3%/3mm VMAT (per beam) 61 93.3% 96.9% 99.1% VMAT (composite) 60 95.6% 98.4% 99.5% Tomotherapy 30 84.7% 96.0% 99.0% Radixact 35 98.1% 99.5% 99.8% Application of statistical process control methods in the retrospective review and design of patient-specific quality assurance processes Scott Crowe,1,2,3 Liting Yu,1,3 Samuel Peet,1,2,3 Tanya Kairn,1,2,3 1Royal Brisbane & Women’s Hospital; 2University of Queensland; 3Queensland University of Technology Conclusions • Control charts allow quantitative review of historical QA data and allow departments to determine tolerance limits specific to their planning, treatment and QA processes. This recommended by TG-2181 as best practice. • Consider how you record QA data and associated plan and dose information, to facilitate review, and in the future, potentially allow that data to be processed by machine- learning QA prediction tools. • Specificity and sensitivity testing in detection of simulated errors will be used to identify appropriate action limits. 90 92 94 96 98 100 0 10 20 30 40 50 60 2%/2mm gamma pass rate Quality assurance test case Individual control chart for VMAT QA results Background • Control charts are used to plot individual QA data points or differences between consecutive data (MR, moving range). • Control limits can be calculated from the QA data: Control limit = തx −2.66 MR • Typically calculated for a build phase, e.g., initial 30 results. • Control limits are tolerance limits and describe expected system performance. QA results beyond limits are assumed to have an assignable cause. Tolerances are distinct from action limits, which are defined by potential clinical impact. References 1.Miften M, et al. Med Phys. 2018;45:53–83. 10.1002/mp.12810 Disclosures The authors have nothing to disclose. The study was exempted from ethical review (EX/2021/QRBW/82062). scott.crowe@health.qld.gov.au Poster presented at EPSM 2022. Questions? Ask me! Calculated limit of 95.6% Out of control QA results Average result of 99.1% Methods Results • Build phase data was not entirely in control for some data, suggesting that there are assignable causes for QA failure. • For simplicity and conformity between modalities, tolerance limits of 95% (and action level of 90%) using 2%/2mm gamma criteria were preferred by the physics team for future VMAT composite and Radixact QA evaluations. • Process performance metrics indicate that our planning, dose calculation, delivery and QA processes should reliably produce plans that are able to meet these tolerance limits. Octavius 1500 data collected for 30+ VMAT, Tomo & Radixact plans. Pass rates calculated for multiple sets of gamma criteria pairs. Charts, limits, and process performance characterised for calculated data. Results and plans for ongoing QA discussed in physics team meeting.


IN VITRO REGENERATION PROTOCOLS FROM IMMATURE MALE FLOWER BUDS OF BANANA CV. KARPURA CHAKKARAKELI (AAB) AND ASSESSMENT OF GENETIC FIDELITY WITH SSR & ISSR MARKERS M. Viswanath 1* B. V. K. Bhagavan2 K. Ravindra Kumar3 P. Subbaramamma4 M. GirijaRani5 *1 Ph.D Scholar, Department of Fruit Science, College of Horticulture, V.R. Gudem, 2 Principal scientist & Head, 3Scientist, 4Associate professor, 5Senior Scientist & Head Dr. Y.S.R. Horticultural University, Venkataramannagudem – 534101, Andhra Pradesh, India. *Corresponding author’s email:viswahorti123@gmail.com An efficient in vitro propagation protocol has been developed for the first time on direct differentiation of shoot buds from immature male flower buds of banana cv. Karpura Chakkarakeli (AAB). MS media supplemented with 1.0 mgL-1 TDZ + 0.5 mgL-1 IAA + 2 mgL-1 CH was found optimal for per -cent cauliflower-like bodies (CLBs) formation (75.04%), maximum number of CLBs (15.01) explant-1 and minimum number of days (43.54d) taken for CLBs induction. The highest per cent (75.37%) and maximum number (12.78) of shoots proliferated explant-1 within 120 days after culture initiation. The regenerated plantlets rooted better in half MS media supplemented with 0.5 mgL-1 IBA and hardened with 97% survival rate. SSR & ISSR markers were employed to assess the genetic stability of in vitro regenerated and multiplied plantlets of banana cv. Karpura Chakkarakeli (AAB) recorded 100% monomorphic across all the regenerated plants with the mother plant. Plate 1. Different stages of in vitro regeneration in banana cv. Karpura Chakkarakeli (AAB). a Mother plant bearing fruits and male flower bud. b Excised male flower bud. c Reduced male floral bud (6-7cm). d A group of male flowers (hands) used for culture. e Floral explants initiated on MS basal medium supplemented with 1 mgL-1 TDZ + 0.5 mgL-1 IAA + 2 CH. f Clusters of Cauliflower-like-bodies (CLBs). g CLBs converting to shoots. h In vitro shoot clusters i Plantlets ready for hardening. Secondary hardened plantlets. . ur s Plate 2. Morphogenic responses from the immature male flower explants of banana cv Karpura Chakkarakeli (AAB) in T14 treatment A. Responded explant (7 DAI) B. Green colo swollen base (15 DAI) C. Perianth necrosis (20 DAI) D. Formation of Cauliflower-like-bodie (CLBs) (30 DAI) E. Formation of shoot buds (60 DAI) F. Shoot clusters(90 DAI). Murashige and Skoog’s (MS) media supplemented with 1.0 mgL-1 TDZ + 0.5 mgL-1 IAA + 2 mgL-1 casein hydrolysate was found optimal for per cent cauliflower- like bodies (CLBs) formation (75.04%), maximum number of CLBs (15.01) explant-1 and minimum number of days (43.54d) taken for CLBs induction. The highest per cent (75.37%) and maximum number (12.78) of shoots proliferated explant-1 within 120 days after culture initiation.The regenerated plantlets rooted better in half MS media supplemented with 0.5 mgL-1 IBA and hardened with 97% survival rate. SSR & ISSR amplified products were 100% monomorphic across all the regenerated plants and mother plant. RESULTS & DISCUSSION MS media supplemented with 1.0 mgL-1 TDZ + 0.5 mgL-1 IAA + 2 mgL-1 CH in 0.25% gel-rite was found optimum for mass production of this commercially important banana cv. Karpura Chakkarakeli (AAB) from IMF buds. CONCLUSION Amplification with SSR & ISSR primers A) Ma-SSR-230 B) UBC 868 300 bp B ABSTRACT INTRODUCTION Karpura Chakkarakeli (AAB), the choicest table cultivar of banana belongs to Mysore subgroup commercially grown in the coastal districts of Andhra Pradesh. Due to its highly recalcitrant nature, excessive phenol compounds, biotic contamination and poor multiplication rate causing the major hindrances for its commercial multiplication through shoot tip explants. Keeping in this view, this study was aimed to examine the potential of male flower explants as an alternate source material for culture establishment, morphogenetic responses and direct organogenesis with different combinations and concentrations of plant


support IL layer metal particle/center Improved electrochemical perfor- mance of Fe-N-C catalysts through ionic liquid modification in alkaline media Thomas Wolker, Ioanna Martinaiou, Ali Shahraei, Gui-Rong Zhang, A. Janßen, Stephan Wagner, Natascha Weidler, Robert W. Stark, Bastian J.M. Etzold*, Ulrike I. Kramm Electrochemistry 2018, 24.-26.09.2018, Ulm correspondence: Prof. Dr.-Ing. B.J.M. Etzold email: etzold@tu-darmstadt.de Ernst-Berl-Institut phone: +49 (0) 6151 / 16-29984 Alarich-Weiss-Str. 8 fax: +49 (0) 6151 / 16-29982 D-64287 Darmstadt http: www.etzoldlab.de literature: [1] Y. Nie, L. Li, Z. Wei, Chem. Soc. Rev. 44 (2015) [2] G.R. Zhang, M. Munoz, B.J.M. Etzold, ACS Appl. Mater. Interfaces 7 (2015) [3] G.R. Zhang, M. Munoz, B.J.M. Etzold, Angew. Chem. Int. Ed. 55 (2016) [4] I. Martinaiou, T. Wolker, B.J.M. Etzold, et al., J. Power Sources 375 (2018) Highly active oxygen reduction reaction (ORR) electrocatalysts that are stable under operating conditions are needed in order to enable a widespread commercialization of the fuel cell technology. State-of-the-art ORR catalysts are mostly based on platinum. Due to their high price noble-metal-free alternatives are highly desirable [1]. Carbon-based materials emerge as one of the promising candidates due to their remarkable advantages of low cost, abundant structural variety, tailorable surface chemistry, and good conductivity. Transition metal-nitrogen-carbon catalysts (e.g. Fe-N-C) are considered as one of the most promising representatives of this catalyst class. However, these systems often show a poor stability during electrochemical cycling and therefore still need to be improved in order to replace state-of-the- art noble metal catalysts. Quite recently we have demonstrated that filling the pores of Pt/C catalysts by a minor amount of Ionic Liquid ([BMIM][NTf2], [MTBD][NTf2]) would significantly boost the catalytic activity of Pt/C for ORR [2,3]. This was explained by the fact that the modification led to a new microenvironment around active centers that would prevent the poisoning with oxygenated species. Inspired by this work, herein we transfer this strategy to the Fe-N-C catalysts [4]. § Fe-N-C catalysts with and without sulfur were prepared § Sulfur addition led to a slightly increased micropore volume § Modification of sulfur free catalysts with [BMMIM][NTf2] increased the catalytic ORR- activity in a similar range as sulfur addition § The different behavior of the sulfur containing catalyst could be explained by pore blocking effects § IL modification could thus be an interesting way to obtain highly active and stable noble- metal free electrocatalysts for fuel cell aplications Introduction Oxygen Reduction Reaction Solid Catalysts with Ionic Liquid Layer (SCILL concept) α = 0 α = 10% α: pore filling degree α = VIL/Vpore,0 The pores of a catalyst are partially filled with Ionic Liquid to create a new microenvironment around active centers Highly active catalyst needed to overcome sluggish kinetics Selectivity towards 4 e- - pathway desired Conclusions O2 OH- HO2- O2 OH- HO2- 2e- 2e- 4e- O2 H2O H2O2 2e- 2e- 4e- Alkaline Acidic Dicyandiamide Iron acetate Phenanthroline Thermal decomposition 800 °C Acid leaching 2nd heat treatment Fe-(S)-N-C Sulfur ( ) ( ) Catalyst Synthesis and Modification Fe-(S)-N-C-SCILL Unreactive species Textural Characterization SBET /m2 g-1 SMicropore /m2 g-1 SMesopore /m2 g-1 VPore /cm3 g-1 -S 416 218 201 0.49 +S 442 299 165 0.44 Nitrogen sorption revealed similar textural properties Electrocatalytic Performance IL Modification can cause similar boosting as sulfur Stability can also be improved by IL addition [BMMIM][NTf2] TW, GRZ and BE acknowledge funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement n° 681719) Acknowledgment + IL


CO-CREATING EXERGAMES WITH PARKINSON’S DISEASE PATIENTS T. Savvidis*, E. Konstantinidis*, S. Dias**, V. Zilidou*, E. Romanopoulou*, L. Hadjileontiadis***, P. Bamidis* *Lab of Medical Physics, School of Health Sciences, Aristotle University of Thessaloniki **Faculdade de Motricidade Humana Universidade de Lisboa Lisbon, Portugal ***Faculty of Technology, Aristotle University of Thessaloniki teo.savvidi@gmail.com, evdokimosk@gmail.com, sbalula@fmh.ulisboa.pt, vickyzilidou@gmail.com, evangeliaromanopoulou@gmail.com, leontios@auth.gr, pdbamidis@gmail.com Introduction In this study, the Minimum Viable Product (MVP) model was applied with regards to “Measure-develop- learn” circle along with its impact on the decision for the development tools and technologies. An example of designing exergames for Parkinson’s disease (PD) patients by considering their valuable feedback [1] and how this influenced low-level technical decisions (changing game engine from 2D Exergames to 3D) are thoroughly discussed. PD Patients feedback Develop Learn/Design Methodology The designing procedure inluded the ivolvement of PD patients in a discussion in which a draft version of the games was presented through storyboards (Figure 1) [1] and followed by a questionnaire. The feedback collected through this process led the developers to design the first game in 2D as part of the wFitForAll web based platform [2][3]. The first 2D prototype game (Figure 2) was presented to the PD patients in an open discussion and a questionnaire has been utilised for the feedback acquisition. The most remarkable point was that although in the design thinking phase the PD patients had reported that they would prefer 2D simple graphics, they were not so enthusiastic but prefered more realistic 3D games. Results The results from the first MVP circle showed that 7/10 patients asked about storyboards/2D would like the abstract/animated design. The second MVP circle leaded to the creation of the Unity 3D prototype. The third MVP circle showed that 3/4 patients asked about the 3D prototype, they liked it more from the 2D. The evaluation process of the second 3D prototype lead us to create more games, 14 in total. Conclusion Using the MVP circles in a spiral way helped us to understand the needs of the PD patients regarding the exergames and develop them more efficiently. The 14 games will be evaluated again in the future during the pilot tests. References 1.S. B. Dias, E. Konstantinidis, J. A. Diniz, P. Bamidis et al., On supporting Parkinson's Disease patients: The i-PROGNOSIS Personalized Game Suite design approach. Computer-Based Medical Systems - IEEE CBMS, Thessaloniki Greece, 2017 2.WebFitForAll platform (www.fitforall.gr). 3.Konstantinidis E, Bamparopoulos G and Bamidis P. Moving Real Exergaming Engines on the Web: The webFitForAll case study in an active and healthy ageing living lab environment, IEEE Journal of Biomedical and Health Informatics, 2016 Acknowledgement The work has been partially supported by the EU H2020-PHC21-2015 ‘i-PROGNOSIS’ Project (N° 690494), as well as, the LLM Care (www.llmcare.gr) self-funded initiative that emerged as the business exploitation of the Long Lasting Memories Project originally funded by the ICT-CIP-PSP programme. We thank Parkinson’s disease association (Thessaloniki, Greece) for their support and their contribution on this study. Figure 1. Storyboard Using the Unity3D, the game was re-developed in 3D with realistic graphics and physics in high resolution (Figure 3) . The realistic physics and the high resolution graphics couldn’t be supported by the Android depth sensor, while the “Low Poly” design adopted, which offers faster rendering because of the small amount of polygons of the model. The final 3D prototype (Figure 4) developed following this new and modern style and improves the Frame per second (FPS) and the gameplay. Figure 2. 2D Prototype Figure 3. First 3D Realistic Graphics Figure 4. Final 3D Design Figure 5. Three out of f


ORIENTACIÓN Y DECORACIONES ASTRONÓMICAS DE HÓRREOS DEL SUR DE GALICIA Las poblaciones de Beade y Vilaboa Cintia Cabada (1,2), Marta González (1,3), Ana Ulla-Miguel (1,2), Fátima Braña (1), Esther Pérez (1,4), Beatriz Martínez (1,5) 1: Grupo de Astronomía, Astrofísica, Antropología Cultura y Educación (A3CE - Universidade de Vigo), 2: Centro de Investigación Mariña (CIM – GEOMA, Universidade de Vigo), 3: Universidad Internacional Valenciana, 4: IES de Beade, Vigo 5: CPI O Toural de Vilaboa e-mail: marta.gonzalezg@professor.universidadviu.com 5- AGRADECIMIENTOS: Un especial agradecimiento al alumnado colaborador del colegio CIP O Toural de Vilaboa y el instituto IES Beade de Vigo. También agradecemos el apoyo del Servicio Público de Empleo Estatal (SEPE) y de la Universidad de Vigo, bajo el contrato E-36-2023-0072917 1- RESUMEN: Los hórreos son construcciones elevadas para conservar el grano características del Norte de España. Actualmente, su interés trasciende su objetivo original y están considerados bienes de interés cultural en Galicia. Esto ha supuesto su protección e inclusión en catálogos oficiales, lo que permite recabar información para su estudio. Por desgracia, los catálogos están dispersos en diferentes entidades, y presentan formatos que dificultan un tratamiento automatizado y robusto de los datos. Este trabajo extiende estudios etnoastronómicos previos de dos parroquias del Concello de Vilaboa. Se presentan muestras consistentes, obtenidas in situ y enfocadas a la decoración astronómica, en las parroquias de Vilaboa y Beade, además de una muestra limpia y homogénea de más de 200 hórreos en la parroquia de Beade procedente del catálogo del Concello de Vigo. En ambas poblaciones, podemos encontrar hórreos que presentan decoración astronómica tanto en adornos sobre el tejado (relojes de sol) como tallados en las paredes de piedra (lunas y estrellas). Por ello, además de caracterizar los datos, se comparan ambas poblaciones desde la perspectiva de la astronomía cultural. 3- METODOLOGIA: 2- OBJETIVOS: ❖Actualizar el registro de los hórreos en dos ubicaciones diferentes (ayuntamiento Vilaboa y parroquia Beade, Vigo). ❖Comparar caracteres cuantitativos y cualitativos entre ambas poblaciones con un enfoque etnoastronómico. ❖Buscar si existe alguna relación entre alguno de los caracteres (principalmente el azimut) y la presencia de decoración con motivos astronómicos. Figura 2 - Hórreos del ayuntamiento de Vilaboa: a- Hórreo de piedra con una estrella de cinco puntas tallada. b- Decoración tallada en piedra de dos rosas hexapétalas. c- Estrella decorativa de cuatro puntas. d- Hórreo de piedra con 3 estrellas de cuatro puntas talladas y un “respiradero” en forma de media luna. Figura 4 - Histogramas de azimut, medidos entre 0 y 180 grados: a- Ayuntamiento de Vilaboa b- Parroquia de Beade Figura 6 - Diagramas sectoriales para los caracteres cualitativos estudiados: a- Parroquia de Beade. b- Ayuntamiento de Vilaboa. 4- CONCLUSIONES: ❖Este estudio ha permitido crear una base de datos de los hórreos en las poblaciones estudiadas y el registro de sus ubicaciones en mapas. ❖La prueba de Kolmogorov-Smirnov (a un 5% de significación) no rechaza la hipótesis nula de que ambas muestras provengan de la misma distribución de azimuts o anchos, pero sí en longitudes. ❖La pequeña concentración en longitudes bajas en la muestra de Beade no está presente en la de Vilaboa, donde ambas dimensiones muestran distribuciones más uniformes. ❖La mayoría (~3/4) de los hórreos en Beade están compuestos de materiales mixtos, mientras que la mayoría (>50%) de los hórreos en Vilaboa están hechos de piedra. ❖La mayoría de las muestras en Vilaboa muestran decoraciones en las paredes, en comparación con ~15% en Beade. En ambos casos, la mayoría tiene motivos astronómicos. Si incluimos relojes de sol, casi un tercio de los hórreos de Beade tienen un elemento astronómico. ❖El uso actual de los hórreos puede haberse visto alterado desde la fecha de recogida


Introduction Discussion Selected references Rayner (1998). Psych Bull, 124(3), 372–422. Vitu (2011). In : The Oxford handbook of eye movements (pp. 731–749). Rayner (1979). Perception, 8(1), 21–30. McConkie et al. (1989). Percept Psychophys, 46(3), 245– 253. Vitu et al. (2001). Vis Res, 41(25-26), 3513–3531. Henderson (1993). Can J Exp Psychol, 47(1), 79-98. van der Linden et al. (2015). J Vis, 15(5), 1–18. van der Linden et al. (2015). Att Percept Psychophys, 1– 16. Nazir et al., (1991). Bull Psychon Soc, 29(2), 171–174. Nuthmann et al. (2007). Vis Res, 47(7), 990–1002. Vitu et al. (1995). Percept Psychophys, 57(3), 352–364. Adeli et al., (2015), VSS. [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] Away from center Away from center Away from center Away from center 3° 5° PVL eﬀects Away from center Away from center versus PVL OVP I-OVP PVL OVP I-OVP Real objects Meaningless non-objects Methods + 3° + + + + Stimulus type (between blocks) Eccentricity (within blocks) 3° 5° 5° Manipulations Real objects Stimuli Non-objects Hemera objects Width 0.85-2.10° Normalized on px Texture synthesis Width constant 0.85° Normalized on px + Task Saccade towards the object as fast as possible Landing positions Normalized x coordinates -0.5 0 0.5 on-object oﬀ-object oﬀ-object -1 1 Laboratoire de Psychologie Cognitive Lotje van der Linden1, Gregory J. Zelinsky2 and Françoise Vitu1 Aix Marseille université cnrs l.vanderlinden@cogsci.nl www.cogsci.nl/lvanderlinden 1. Aix Marseille Université, CNRS, Laboratoire de Psychologie Cognitive UMR 7290, Marseille, France 2. Department of Psychology, Stony Brook University, New York, United States Viewing-position eﬀects in meaningless object viewing PVL OVP vêtements vêtements vêtements I-OVP Frequency Reﬁxation probability Initial-ﬁxation duration Eye movements during object viewing → same regularities [6-8] The center of a stimulus is optimal for visual extraction [9] 20° 10° 0° 10° 20° 40° 60° 0.0 0.2 0.4 0.6 0.8 1.0 Fovea Relative visual acuity vêtements Degrees from fovea Eye movements during reading → regularities [1, 2] Eyes land near the center of words → preferred viewing location (PVL) eﬀect [3] Central landing positions result in less reﬁxations → optimal viewing position (OVP) eﬀect [4] and longer initial ﬁxation durations → inverted OVP (I-OVP) eﬀect[5] We know that... Several nocturnal animals were observed. Normal condition Zzzzzzz zzzzzzzzz zzzzzzz zzzz zzzzzzzz. Z-reading condition versus Diﬀerences → cognitive processing Similarities → visuomotor processing Real objects Meaningless non-objects versus Are PVL, OVP and I-OVP eﬀects Directly caused by these visual-processing advantages? e.g. PVL = strategy to aim at center to optimize visual-information uptake All eﬀects generalize to mindless reading e.g. 10, 11] Is the same true for mindless object viewing? Or are they visuomotor processes? e.g. PVL = automatic center-of-gravity eﬀect Research question: Regularities during reading reﬂect visuomotor constraints PVL, OVP and I-OVP generalized → The eyes prefer to land at, and stay at, the center of stimuli We found that... regardless of stimulus content This suggests that... PVL, OVP and I-OVP eﬀects reﬂect low-level visuomotor processing and not higher-level ongoing processing such as object recognition This is important for... models on eye guidance in scenes increased predictive power whenimplementing visuomotor constraints [12] Results


GND in a Nutshell Ein Normdatensatz beschreibt regel- basiert eine bestimmte Entität. Die Datensätze enthalten Informationen, die die entsprechende Entitäten ex- plizit charakterisieren und so identifizieren. Die Gemeinsame Normdatei (GND) ist ein Dienst, um Normdaten kooperativ nutzen und verwalten zu können. Diese Normdaten reprä- sentieren und beschreiben Entitäten, wie Personen, Körperschaften, Kon- ferenzen, Geografika, Sachbegriffe und Werke, die in Bezug zu Kulturgut sowie kulturellen und wissenschaft- lichen Sammlungen stehen. Anforderungen sammeln Auf der Grundlage vorliegender Erfahrungen aus der Text+ Community, die zum Beispiel über die zahlreich eingereichten User Stories gesammelt wurden, werden Bedarfe an eine GND- Agentur ermittelt. Diese Aufgabe führen wir im Rahmen verschiedener Formate wie dem GND-Forum weiter, wobei ein Ergebnisbericht zum Dezember 2023 vorliegen wird. In Case Studies überführen Die ermittelten Bedarfe werden in Case Studies überführt. In der Datendomäne Editions schauen wir anhand von drei Editions- projekten an der SUB Göttingen, wie die Bedarfe an GND-Norm- datensätzen in konkreten Work- flows umgesetzt werden können. Ähnlich werden wir für die Datendomänen Collections und Lexical Resources verfahren. Die Workflows aus den Case Studies sollen in allgemeine, skalierbare Workflows bis April 2024 übertragen werden. Prototypische Strukturen testen Wir möchten die bereits vorhandenen und in Planung befindlichen Strukturen testen. Damit wollen wir gewährleisten, dass die technischen, administrativen und daten- theoretischen Strukturen der Agentur für die Text+ Community adäquat sind. Die Produktivnahme ist zum Juni 2025 geplant. Das NFDI-Konsortium Text+ wird gefördert durch die Deutsche Forschungsgemeinschaft (DFG) unter der Projektnummer 460033370. Text+ ist Teil der Hintergrund: „Frankfurt am Main“ im GND-Explorer. DNB 2022. CC BY-SA 3.0 Icon Nutshell: Tatyana. Noun Project. Icon Road: Sergey Krivoy. Noun Project. beide CC BY 3.0 https://gnd.network/Webs/gnd/DE/UeberGND/FAQ/faq_node.html Agenturaufgabenbaum. Jürgen Kett, DNB, Mai 2022. CC BY-SA 3.0 Task Area Infrastructure/Operations Ein Baum in der Roadmap Kontakt: gnd-info@dnb.de Poster: „Ein Baum in der GND – Gemeinsame Normdatei“ Inhalt: Text+ Infrastructure/Operations Verantwortlich: Marie Annisius , Barbara Fischer , Alexander Steckel Event: Text+ Plenary, 12-13. September 2022, Mannheim


An Exploration of <object> using Antarctic Artifacts Suzanne Raybuck and Sarah Stanley Problem The recent inclusion of <object> to the TEI has been a long-awaited addition to the language that was adapted from the msdescription module. With this project, we set out to test the effectiveness of the <physDesc> element within <object> and the effectiveness of the current concept of describing general objects. Methodology To test the effectiveness of <physDesc>, we selected six objects from FSU Special Collections. These objects demonstrated a variety of physical characteristics we wanted to capture. We then described these objects in as much detail as possible through observation then took the resulting document and converted it into descriptive markup in the TEI. While marking up our descriptions, we paid special attention to which current child elements of <physDesc> were applicable to the object. We also tested how the current content model restricts accurate description and markup. Based on this markup we then created an ODD file to add elements that would address the observations and questions we had while initially describing the objects. Result and Discussion We produced six descriptions of our objects to test the utility of <physDesc> and its child elements <objectDesc>, <decoDesc>, and <typeDesc>. Each object presented a different challenge to describe and resulted in a number of questions about the current version of <physDesc>, such as: • What is the difference between <physDesc> and <objectDesc> when describing objects and not manuscripts? • Are the current child elements from the msdescription module still applicable to general objects? • How do we subdivide objects into parts that can be described within <physDesc>? Based on our observations, we decided to create two models for segmenting objects for description: one that was meant to segment the descriptions themselves, and another that segmented the objects and linked these segments to their descriptions. Figure 7. Model of a United States Navy Icebreaker. Figure 3. U.S. Naval Mobile Construction Battalion Plaque. Figure 1. Ceramic Penguin Figurine. Customization #1 – <objectSector> • Creates an <objectSector> element within <object> which lays out segments of the object • Assigns an @xml:id for linking to corresponding prose in <objectDesc> • Considers the segmentation of the object information about the object itself Figure 5. Navy Icebreaker description using <sectorDesc>. Customization #2 - <sectorDesc> • Creates a <sectorDesc> within <objectDesc> element • Provides the user a way of being more precise by segmenting the description of the object • Considers segmentation a feature of the description, rather than the object Both Customizations • Created subdivisions of objects for more nuanced description • Allow for the use of @place to segment the objects • Utilize custom att.3Dcoordinates which allows the user to define a box-like space that encloses the area being described. Ideally these coordinates will map onto some 3D model of the object Figure 4. Navy Icebreaker description using <objectSector>. Figure 6. Schema for our att.3dcoordinates attribute class. View all our files for this project in our GitHub repository at https://github.com/sraybuck/AntarcticObject Figure 2. Emergency Lantern.


libEnsemble: New capabilities for coordinating dynamic ensembles of calculations Stephen Hudson Jeffrey Larson John-Luke Navarro Stefan M. Wild Overview libEnsemble is a Python toolkit for coordinating dynamic, asynchronous ensembles of calculations on massively parallel resources. Worker processes launch simulation and generator functions. libEnsem- ble also provides: • Ad-hoc task generation • Dynamic Resource management • Application monitoring • Portability and ﬂexibility • Coordinating data-ﬂow between tasks • Low startup cost: pip install libensemble • Conﬁgure via Python scripts or yaml/toml/json Cross-System Ensembles libEnsemble can submit remote apps and user functions via the Balsam and funcX platforms. With Balsam: Remote applications With funcX: Remote simulation functions Multiﬁdelity optimization of a WarpX laser-plasma simulation Multi-ﬁdelity simulations have demon- strated 10x speedup over single ﬁdelity equivalents. Progress from ten replications of libEnsem- ble+WarpX with two multiﬁdelity meth- ods and a single (highest) ﬁdelity method. Objective value is computed from the highest ﬁdelity simulation. Variable Resource Management libEnsemble’s Resource Manager now divides resources into resource sets that can be assigned (and dynamically reas- signed) to workers. This enables easy support of multi-ﬁdelity simulations. Community Examples and Integrations The libEnsemble repository includes many simple exam- ple functions. Users can also now contribute to a separate growing library of functions and complete workﬂows, encouraging maximum code re-use. Example genera- tors include optimization, calibration, machine learn- ing, and many others. Libensemble/libe-community-examples All Workﬂows are Portable • Summit • Polaris • ThetaGPU • Perlmutter A New Pythonic Interface Download or Contribute Available through pip: pip install libensemble conda through conda-forge channel: conda install -c conda-forge libensemble Spack: spack install py-libensemble GitHub: http://github.com/Libensemble/libensemble Read the Docs: https://libensemble.readthedocs.io


Primary cilium remodelling mediates a cell signalling switch in differentiating neurons Gabriela Toro-Tapia1 and Raman M. Das1. 1Division of Molecular and Cellular Function, Faculty of Biology Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. INTRODUCTION • Neurons are amongst the most highly polarised cell types [1,2]. • Cells undergoing neuronal differentiation shed their apical membrane via the regulated process of apical abscission [3], leading to acute loss of cell polarity and delamination from the neuroepithelium (A,B). • Apical abscission also results in disassembly of the apical primary cilium, leading to curtailment of Shh signalling and onset of cell cycle exit (C). • Newborn neurons repolarise in response to extracellular signals, leading to extension of a nascent axon in the correct orientation. Figure 1: A) Cartoon represents a two-day-old chick embryo. The transverse section of the spinal cord shows the apicobasal polarity of neural progenitors and the sequence of events leading to neuronal differentiation. B) The primary cilium and centrosome are located at the apical pole of cells in the early stages of neuronal differentiation. C) Apical abscission leads to acute loss of apical polarity and primary cilium dis-assembly. B C RESULTS CONCLUSIONS References: [1] Takano, T., et al. (2015). "Neuronal polarization." Development 142(12): 2088-2093;[2] Barnes, A. P. and F. Polleux (2009). "Establishment of axon-dendrite polarity in developing neurons." Annu Rev Neurosci 32: 347-381;[3] Das, R. M. and K. G. Storey (2014). "Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis." Science 343(6167): 200-204. A I) The primary cilium is dynamically disassembled and remodelled during neuronal differentiation II) Intraflagellar trafficking is inactive in the Arl13b+ particle and reactivated during apical process retraction • Cells delaminating from the neuroepithelium undergo primary cilium dis-assembly and inherit a small Arl13b+ particle, leading to acute cessation of canonical Shh signalling. • Arl13b+ particle elongates and progressively initiates intraflagellar trafficking (IFT) as it transits towards the cell body, indicating primary cilium remodelling. • Ciliary accumulation of the Shh transducer Smoothened (Smo) is gradually restored during cilium remodelling in the absence of Gli transcriptional activity. • The remodelled primary cilium directs neuron polarisation and subsequent axonogenesis via a non-canonical Shh signalling. • This work indicates that cilium remodelling provides differentiating neurons the opportunity to configure a new signalling centre to facilitate a qualitatively different response to the common signalling environment. Apical process { Figure 2:. A) Time-lapse sequence showing Arl13b+ particle retention following apical abscission. White arrow indicates apical abscission, white arrowhead the retained Arl13b+ particle and yellow arrowhead the abscised primary cilium. Dashed magenta lines indicate ventricular surface. Scale bar: 10µm. Boxed regions are enlarged in right-hand panels. Primary cilium is highlighted by dashed white lines. Scale bar: 0.7µm. B) Time-lapse sequence of a cell undergoing primary cilium reassembly during apical process retraction. Dashed cyan lines demarcate cell body of differentiating neuron and white arrowhead the reassembling primary cilium. Boxed regions are enlarged in right-hand panels. Scale bar: 5µm and 0.7µm (enlarged region). C) Cell undergoing axonogenesis transfected with Arl13b-GFP to label the ciliary membrane (green), mKate2-GPI to label cell membrane (red), and Ngn2-GFP (green), Scale bar: 5µm. D) Representation of differentiating neurons at different stages of apical process retraction and early stages of axonogenesis. E) Immunostaining to detect Tuj1+ cells (green) and endogenous Arl13b (red) at different stages of apical process retraction. Scale bar: 5µm an


System Development for Potato Crop Growth Management Tao Zheng, Meng Cheng, Hong Sun *, Minzan Li, Wei Yang, Lihua Zheng, Man Zhang Key Laboratory of Modern Precision Agriculture System Integration Research Ministry of Education Key Laboratory of Modern Precision Agriculture System Integration Research, Ministry of Education, China Agricultural University, Beijing 100083, China. sunhong@cau.edu.cn A large number of data on the growth of potato crops and environmental parameters were collected through the sensor during the growth of the potato crop. In order to improve management efficiency and provide production decisions, a system for potato crop growth management was developed. The system can store, retrieve, manage and make decision on potato crop growth, and provide guidance for real-time monitoring and optimization of crop growth process. The system is a convenient, fast, efficient and low-cost agricultural management system. Introduction The system selected the current mainstream J2EE architecture, SSH framework, the database using MySQL, and the application of Eclipse for system development, forming a clear framework to improve the reusability of t Methods Non-destructive detection of chlorophyll content of potato crop leaves can indicate crop growth and guide field management. The hyper-spectral images of 65 potato leaves were collected and divided into 400 regions of interesting (ROI) Meanwhile the SPAD values of these 400 ROI Experiment and Discussion , g g y Fig. 1 SSH framework components. (ROI). Meanwhile, the SPAD values of these 400 ROI samples were measured. All of the data mentioned above could be managed by the system. After long-term operation, the software system ran normally. Moreover, the data could achieve the correct load and output. In the future, the system could be optimised and used to connect with the farmland information collection device. Wh th t i th fi ld Th i d t Th t i di id d i t f d l i f ti When the sensors were set up in the field. The sensing data could be collected data every 5 minutes and sent it to the server. The software system then retrieved the data from the server for management and subsequent processing. The system is divided into four modules information platform and auxiliary functions. i. Common operation module related to the management for farmland data and user data. ii. System management module viewed the data collected in the experiment and spectral data analysis results. iii. Information platform module mainly aimed at the function of agriculture warning. iv. Auxiliary functions module had a very strong expansibility, and viewed the mapping analysis and so on. Fig. 3 The system operating result The system reduced a large number of system requirements analysis and system development costs, and provided Fig. 2 The structure of software system effective information support for special users with specific needs. The system makes it easy for people to search and query information about growing potato crops. 1. The system considered the optimal allocation of environmental resources, cultivated land resources, Conclusions and Acknowledgements varieties and chemical fertilizers, such as light and warm water produced by potato crop. 2. The system realized the data synchronization between the server and the browser. Users could make real- time use of information to make timely agricultural decision-making. 3. This study was supported by Research on Rapid Diagnosis Method and Mechanism of Nitrogen Nutrition of Dry-planted Potato Crops Supported by the National Natural Science Foundation of China (31501219). 照片 Tao Zheng


Neutrino quantum decoherence in supernovae explosions Vasily I. Bokov1, Konstantin L. Stankevich1, Alexander I. Studenikin1,2 1. Faculty of Physics, Lomonosov Moscow State University, Moscow 119991, Russia 2. Joint Institute for Nuclear Research, Dubna 141980, Moscow Region, Russia Correspondence: kl.stankevich@physics.msu.ru; studenik@srd.sinp.msu.ru 1 Introduction We study the inﬂuence of the neutrino quantum decoherence (see [1–4] and references therein) on collective neutrino oscillations. Collective neutrino oscillations is a phenomenon engendered by neutrino-neutrino interaction. It is signiﬁcant in different astro- physical environments where the neutrino density is extremely high. Examples of such environments are the early universe, su- pernovae explosions, binary neutron stars, accretion discs of black holes. The effect of collective neutrino oscillations attracts the growing interest in sight of appearance of multi-messenger astron- omy and constructing of new large-volume neutrino detectors that will be highly efﬁcient for observing neutrino ﬂuxes from super- novae explosions. Previously, it was shown that neutrino quantum decoherence can signiﬁcantly modify the neutrino ﬂuxes from reactors and the sun. Here below we study the inﬂuence of the neutrino quantum de- coherence on supernovae neutrino ﬂuxes. The peculiarity of the supernovae ﬂuxes is that one of the main modes of neutrino oscil- lations in supernovae is engendered by the collective effects. We note, that previous works dedicated to collective neutrino oscilla- tions (see [5] and references therein) accounted only for the kine- matical decoherence. 2 Equations of motion Consider the two-ﬂavor neutrino mixing scenarios, i.e. the mixing between νe and νx states where νx stands for νµ or ντ. Here below we focus on the derivation of the neutrino oscillation probability and highlight the interplay between collective neutrino oscillations and neutrino quantum decoherence. We use the simpliﬁed model of supernova neutrinos that was considered in [6, 7]. In such a model neutrinos are produced and emitted with a single energy and a single emission angle. The neutrino evolution in supernovae environment that accounts for neutrino quantum decoherence is determined by the following equation idρf dt = [H, ρf] + D[ρf] , id¯ρf dt = [ ¯H, ¯ρf] + D[¯ρf], (1) where ρf (¯ρf) is the density matrix for neutrino (antineutrino) in the ﬂavour basis and H ( ¯H) are total neutrino (antineutrino) Hamiltonian. Neutrino quantum decoherence is described by the dissipation term D[ρ] that we deﬁne in the next section. Hamiltonian H contains the three terms H = Hvac + HM + Hνν, (2) where Hvac is the vacuum Hamiltonian, HM and Hνν are Hamil- tonians that describe matter potential and neutrino-neutrino inter- action correspondingly. In the ﬂavour basis they are given by Hvac = δm2 4E −cos(2θ) sin(2θ) sin(2θ) cos(2θ)  , (3) HM = √ 2 2 GFne 1 0 0 −1  , (4) Hνν = √ 2GFnν (1 + β)ρf −α(1 + ¯β)¯ρf  , (5) where β represents the initial asymmetry between the electron and x-type neutrinos, and ¯β the asymmetry between electron and x- type antineutrinos, α is the ratio of electron antineutrinos relative to electron neutrinos, ne and nν describe the electron and neutrino density proﬁles. 3 Neutrino quantum decoherence In our previous studies [1–4] we developed a new theoretical framework that enabled one to consider a concrete process of parti- cles interactions as a source of the decoherence. In particular, in [1] a new mechanism of neutrino quantum decoherence engendered by the neutrino radiative decay. In parallel, another framework was developed [8, 9] for the description of the neutrino quantum decoherence due to the non-forward neutrino scattering processes. Both mechanisms are described by the Lindblad master equation in form [10,11]. In this paper we are are not interested in a speciﬁc mechanism of neutrino quantum decoherence. Therefore, we use the Lindblad master equation for the descr


DATABASE OF COPYRIGHT AND OPEN ACCESS SELF-ARCHIVING POLICIES OF POLISH SCIENTIFIC JOURNALS About: Only 79 publishers from Poland and only 319 policies of Polish journals are registered in the Sherpa/RoMEO database which shows copyright and Open Access self-archiving policies. At the same time, there are over 4,500 journals published in Poland. Not only do Polish authors have problems ﬁnding information about the policies of the other journals. This is often a big challenge for foreign authors. Lack of information or diﬃculty in accessing it also present problems for librarians who manage institutional repositories. Hence the idea of creating Database of Copyright and Open Access Self-Archiving Policies of Polish Scientiﬁc Journals which is to serve as a tool for authors and librarians. The database is also to supply the Sherpa/RoMEO database with current data. Self-Archiving Policies of Polish Scientific Journals Database Open Science Competence Center - Gdansk University of Technology Library Bridge of Knowledge Open Access resources Open Research Data Repository Virtual Microscope Open Access Journals Publishing Service PROJECT a an at a D ly t g ic i s B Our Team · 18 team members from GUT Library (diﬀerent disciplines and specializations) How do we do it? · Checking a journal's websites and databases (e.g. DOAJ,SHERPA/RoMEO) · Contacting with the journals' publishers · Gathering information in our institutional CRIS, which is called My GUT · Providing public access to the content of the database on Bridge of Knowledge Platform · The database is a support for scientists who apply for research funding · It is a guide which shows relevant and veriﬁed information · It is a reliable source for information about how to select the most suitable journal for publication of an article · It shows diﬀerent Open Access options dr Anna Wałek anna.walek@pg.edu.pl Beneﬁts for libraries Our greatest challenges GUT LIBRARY The database is currently in the phase of development and will eventually be a part of the Bridge of Knowledge platform dedicated to Open Science Kamila Kokot kamila.kokot@pg.edu.pl authors: www.mostwiedzy.pl The Bridge of Data is co-ﬁnanced by the European Regional Development Fund within the the framework of an Operational Programme Digital Poland for 2014-2020 · Checking the publishing policy · Selecting and verifying of information · Collecting data · Training and promoting of Open Science The role of Library's team Project in numbers · Starting point – October 2018 · Total number of Polish scientiﬁc journals: 4500 · Checked policies until June 2020: 1 376 · Veriﬁed policies: 950 · Open Access policies: 838 Beneﬁts for researchers · The database is a convenient tool for librarians to support researchers It is a quick way to ﬁnd relevant information from various sources · It is adapted to the new requirements set out by the most important · funding institutions in Poland (eg. National Science Centre, Ministry of Science and Higher Education) · Lack of information or incomplete information about the licenses and self-archiving policies on publishers' websites · Unobtainable websites and broken links · Lack of knowledge about Open Access aspects (problems with basic deﬁnitions, unawareness on topics dealing with copyright and CC licenses) · Lack of contact, or trouble contacting publishers https://orcid.org/0000-0002-3355-5198 https://orcid.org/0000-0001-8782-013X graphic design: Tytus Caban https://orcid.org/0000-0002-4391-7009 This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) Since the 2016 Gdańsk University of Technology implements a project called Multidisciplinary Open System Transferring Knowledge - the Bridge of Knowledge (pol. MOST Wiedzy). An essential part of the platform is the open repository of scientiﬁc publications, currently being developed towards a research data repository, as a part of the second stage of the project called The Bridge of Data. As part of the proj


Poster nr.: 421.08 −10 −5 0 5 10 value −10 −5 0 5 10 value -5 8 Natural History Placebo Video instructions and practice phase Placebo+Conditioning Standard task General Questionnaires Electrode preparation Waiting (10 min) Expectation Questionnaire 1 Standard task Manipulated task Experience Questionnaire 1 Sham tACS Expectation Questionnaire 2 Standard task Experience Questionnaire 2 Sham tACS Task 1 Task 2 Task 3 Block 2 Block 3 Anticipated (before) Experienced (after) decrease neutral improve decrease neutral improve 0 10 20 30 0 10 20 30 n Group NHG Placebo Placebo+Conditioning Expected and experienced changes in performance (forced choice) ● ● ● ● ● ● ● ● ● ● ● ● Anticipated (before) Experienced (after) 2 3 2 3 10 20 30 40 task value Group ● ● ● NHG Placebo Placebo+Conditioning Expected and experienced changes in performance (estimate) ● ● ● ● ● ● ● ● ● Total reward 1 2 3 200 300 400 task Reward Group ● ● ● NHG Placebo Placebo+Conditioning ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● alpha beta w NHG Placebo Placebo+conditioning −2 0 2 4 0.00 0.25 0.50 0.75 −0.5 0.0 0.5 1.0 1 2 3 1 2 3 1 2 3 val Task Task effects ● ● ●● ● ● ● ● ● ● 0.25 0.50 0.75 1.00 beta 0.25 0.50 0.75 1.00 alpha ● ● ●● ● ● ● ● ● ● 0.25 0.50 0.75 1.00 w 0.25 0.50 0.75 1.00 alpha ● ● ● ● ● ● ● ● ● ● 0.25 0.50 0.75 1.00 w 0.25 0.50 0.75 1.00 beta group 100 200 300 Expected Reward NHG Placebo Placebo+ Conditioning ● ● ● ● ● ● ● ● ● ● 0.1 0.2 0.3 0.4 beta 0.85 0.90 0.95 1.00 alpha ● ●● ● ● ● ● ● ● 0.3 0.4 0.5 0.6 0.7 w 0.85 0.90 0.95 1.00 alpha ● ● ● ● ● ● ● ● ● 0.4 0.5 0.6 0.7 w 0.1 0.2 0.3 0.4 beta q


@ F A C EITArcti c @ F A C EITArcti c @ fa c e _i t_arc tic @ The F A C E -IT Pro j e ct www.face-it-project.eu FACE-IT has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 869154. The Porsangerfjord in Northern Norway is a sub-arctic fjord with an inner arctic part and face an invasion by the red king crab Paralithodes camtschaticus since the end of the 1990’s. This offers the opportunity to study the dynamics of an Arctic ecosystem facing multiple stressors, i.e., climate change and invasive species. The Inner Fjord as a Refugium In the Porsangerfjord, fish species respond to climate change while bottom-living (= benthic) invertebrates are more threatened by invasive species such as the king crab. Fish diversity increases towards the inner fjord due to Arctic cold-adapted assemblages overlapping with newly arriving warm-adapted species. This effect was not observed in bottom- living invertebrates, yet the refuge function of the inner fjord might be unbalanced due to the red king crab’s predation on Arctic species. Red King Crab Paralithodes camtschaticus Climate Change Response in a Sub-Arctic Fjord: Fishes and Invertebrates Respond DifferentlyLaurène Mérillet1,2, Morten D. Skogen1,2, Frode Vikebø1,2, Lis LindalJørgensen3 1Institute of Marine Research, Bergen, Norway 2Bjerknes Centre for Climate Research, Bergen, Norway 3Institute of Marine Research, Tromsø, Norway Berengere.Husson@hi.no The main environmental changes in the fjord were: • freshening of the water • increase of the seabed current • decrease of the maximum sea ice extent. Species richness and diversity of fishes significantly increased into the fjord, due to the arrival of warm-water species over time that overlapped with cold-water species that have seen their biomass significantly reduced. No significant decrease in the biomass of the cold-water benthic (= sea floor associated) species was visible, which could indicate an efficient refugee effect of the inner fjord. Sampling areas between 2007 and 2019 Examples of bottom-living invertebrates Get Mérillet et al. 2022


Department of Computer Science, University of Helsinki Tommi Meskanen and Valtteri Niemi (tommi.meskanen@helsinki.fi, valtteri.niemi@helsinki.fi) Trust, Security and Privacy for HELIOS HELIOS is an EU Horizon 2020 project • duration of 3 years • budget 5 million euros • 15 partners around Europe, both industrial and academic HELIOS is a social media platform that is • modular • peer-to-peer • open-source • open for developers to build their apps on One of the main concepts of HELIOS platform is Trust. • Trust level is automatically calculated for other users the ego connects to. • Trust level is calculated based on the frequency and level of interactions between the ego and other users. No central authority. Security is based on encryption and authentication using the public keys that every user has and that are shared to their friends. For Privacy • all communication between users is end-to-end encrypted • all files on the users’ devices are encrypted HELIOS is able to identify the Context the user (Ego) is in. Based ot the context HELIOS decides which friends (Alters) or activities should have priority. The HELIOS platform enables users to create Ad Hoc groups • users can join and leave. • all communication in the group is again encrypted • people outside the group cannot read it


A Finite Element Study on the Biomechanics of Intracorneal Implants in Keratoconus Corneal Models Shima Bahramizadeh Sajadi1, Hamid Reza Katoozian2, Philippe Büchler3 1,2Department of Biomedical Engineering, Polytechnic of Tehran, Tehran, Iran 1,3Computational Bioengineering, ARTORG Center for Biomedical Engineering Research Introduction • Keratoconus (KC) is a progressive corneal disease characterized by thinning, weakening and steepening of the cornea. • KC progression is manifested by corneal protrusion, irregular astigmatism and severe unilateral and bilateral myopia. • The prevalence is 0.05% in Western countries but higher in the Middle East and Asia (0.76% - 3.30%). • KC-associated anatomical deviations strongly impact the patient’s vision and quality of life. • The etiology of KC is not well understood and there is no cure. • Corneal geometric alterations affect ophthalmic surgical plans. • Intracorneal ring segment (ICRS) implantation proved to be a clinically effective approach in retrieving the corneal curvature in more advanced stages of the disease. • Empirical nomograms are used by clinicians to define the surgical planning. Nomograms provide a homogenized view of the treatment. GOALS → Ring implant simulations in prediction of post-surgical deformation and internal stresses → To investigate geometrical features of ICRS surgeries to propose personalized sets of segments based on each patient’s corneal topographic maps Results and Discussion • Generic models Methods • A round, central KC cornea was modeled with physiological intraocular pressure. • Combination sets of ICRS implants were considered. References [1]. Flecha-Lescún, et al., Biomech Model Mechanobiol, 2018: pp. 1-16. [2]. Ariza-Gracia, 2020. Transl. Vis. Sci. Technol., 9(11), pp.26-26. [3]. Kling, S. and Marcos, S., Invest Ophthalmol Vis Sci, 2013. 54(1): pp. 881-889. [4]. nkcf.org, National Keratoconus Foundation Gallery. Ongoing/Future Work • Patient-specific models • Characterizing mechanical properties of corneas


NuSTAR results + conclusions Methods Motivations Mathematisch- Naturwissenschaftliche Fakultät Using Vela X-1 to understand accretion and wind structure in High-Mass X-ray binaries (HMXBs) 60 58 56 54 52 50 48 12 10 8 6 4 2 35 30 25 20 ECRSF,H [keV] Luminosity [1036erg s−1] ECRSF,F [keV] 1 0.8 0.6 0.4 0.2 0 100 80 60 40 20 0 CF NH,1 [1022cm−2] • Vela X-1: convenient physical parameters (close distance, high inclination, small orbital separation) which facilitate the observation and analysis of the system • Two observations taken on January (NuSTAR) and May 2019 (simultaneous NuSTAR+XMM-Newton) at orbital phases ~0.68–0.78 and ~0.36–0.52, respectively 0.6 0.4 0.2 0.0 0.8 0.6 1400 1200 1000 800 600 400 200 0 Rate [mCrab] Phase single-absorption model best-ﬁt model without 10 keV feature best-ﬁt model without CRSF best-ﬁt model 1 0.1 0.01 10-3 a) 0 b) 1 0.5 c) 1.2 1 d) 70 50 30 20 15 10 7 5 4 3 1.2 1 Counts s−1 keV−1 χ Ratio Ratio Energy (keV) Ratio References XMM-Newton PN analysis • Preliminary XMM-Newton results showing a strong variation of the absorption column density of the stellar wind along the orbital phase when the wakes are passing through the line of sight • drops after flaring episodes, which can be explained by accretion of clumps thus reducing the density of the material. NH,1 [1] C.M. Diez, V. Grinberg, et al. 2022, Continuum, cyclotron line, and absorption variability in the high-mass X-ray binary Vela X-1, A&A 660, A19 [2] El Mellah, et al. 2018, Accretion from a clumpy massive-star wind in supergiant X- ray binaries, MNRAS 475, 3240–3252 [3] Mushtukov, et al. 2014, On the origin of cyclotron lines in the spectra of X-ray pulsars, EPJ Web of Conferences 64, 02005 [4] Fürst, F., Pottschmidt, K., Wilms, J., et al. 2014, NuSTAR discovery of a luminosity dependent cyclotron line energy in Vela X-1, ApJ, 780, 133 [5] C.M. Diez, V. Grinberg, I. El Mellah, et al., paper in prep. [3] [1] Fig. 6: Spectral parameter as function of the 3-79 keV luminosity based on our orbit-by-orbit spectroscopy results ( for observation I, for observation IIa, and for observation IIb) together with ks-integrated spectral fits from Fig. 7 in [4] ( ). Upper panel: photon index . The black dot-dashed line is a linear regression through all data points, meant to guide the eye. Middle panel: energy of the harmonic cyclotron line . The black solid line is the theoretical prediction for = 1, = 30 keV and = 1.9 . The above and below dot-dashed lines are for = 1.7 and = 2.1 respectively. Lower panel: energy of the fundamental line . Γ ECRSF,H Λ ENS MNS M⊙ MNS M⊙ MNS M⊙ ECRSF,F Fig. 5: Stellar wind absorption as function of the covering fraction based on our orbit-by-orbit and pulse-by-pulse spectroscopy results. are the results of the orbit-by-orbit analysis and of the pulse- by-pulse analysis both for observation I, are the results of the orbit-by- orbit spectroscopy and of the pulse-by-pulse spectroscopy both for observation IIa, are the results of the orbit-by-orbit spectroscopy and X of the pulse-by-pulse spectroscopy both for observation IIb. NH,1 CF Fig. 4: NuSTAR 3–79 keV flux for observation I (red) on January 2019 and observation II on May 2019 (blue) and Swift/BAT 15—50 keV flux averaged over all data since 2005 (black solid line) plotted over the neutron star’s orbital phase where 0 is defined with T90. Fig. 3: Time-averaged spectrum for observation I. FPMA data in red and FPMB data in blue, models for both focal plane modules are shown in the same color and are hardly distinguishable with the naked eye. The first panel shows the count spectrum. Top-down description of the residual panels: a) best-fit model (black), b) best-fit model with CRSFs (yellow) turned off but not fitted again, c) best-fit model with 10-keV feature (green) turned off but not fitted again, d) single-absorption model (magenta). C. M. Diez1, V. Grinberg1,2, F. Fürst3, E. Sokolova-Lapa4,5, A. Santangelo1, J. Wilms4, K. Pottschmidt6,7, S. Martínez-Núñez8, C. Malacar


A High Resolution H- and K-Band Spectroscopic Sequence of Ultracool Dwarfs Jennifer J. Greco1,2,3, Michael C. Cushing3 1. Uppsala University, 2. The Swedish Collegium for Advanced Study, 3. University of Toledo To see the full online interactive version of this poster scan this QR code or go to: http://astro1.panet.utoledo.edu/~jgreco/posters/cs20p5 •Ultracool dwarfs have been studied extensively using photometry and low- and moderate-resolution spectroscopy, but rarely using high-resolution spectroscopy. •We have assembled the first high-resolution H- and K-band spectroscopic sequence of ultracool dwarfs. Our sample contains 31 objects with spectral types ranging from M1.5V to T6, and also contains low-gravity objects at five spectral types (M9, L0, L1, L2, L3, L5). •All spectra were obtained using the Immersion GRating INfrared Spectrometer (IGRINS) on the 4.3 meter Lowell Discovery Telescope at a resolving power of R~45,000. • We compared 22 of our objects to synthetic spectra created from the atmospheric models of Saumon & Marley 2008. •We fit both the whole K-band (2.05-2.35𝜇m) and the CO band (2.27-2.35𝜇m), to obtain estimates of Teff, logg, vsini, fsed for our objects. • Shown here as an example are the CO band and K-band fits for the T2.5 dwarf SIMP0136+09. The best fitting model for each is shown in cyan. • We find that our Teff values (shown in blue) are high when compared to those calculated using photometry by Filippazzo et al 2015 (shown in black) but agree well with those found using the same models at moderate resolution by Cushing et al 2008 (shown in red). •We also find that the Teff values obtained in the CO band are all greater than or equal to those obtained in the K-band. •We find similar systematic differences between the values of logg, vsini, and fsed from the K-band and CO band fits (see online version of poster for more information). •We are still investigating the cause of these systematic differences. If you have any questions please email jennifer.greco@physics.uu.se


0 1 2 3 4 5 10 15 20 25 0 1.6875 3.375 6.75 12.5 25 50 100 Generation Crossed to Domestic % Bengalness Theoritical Asian Leopard Cats BxL LxD BxD Random Bengal Breed cats % Bengalness 0 25 50 75 100 ALC LxD BEN ACURL BOM BUR CREX EGY MANEE PERM MCOON MUNCH ORI PBALD RBLUE SREX SIR SPH VAN BxL BxD ABY BIR BSH CHR DREX JBOB KOR LYK MANX NFC PER RAG SFOLD SIA SOM TREX WIR Findings: 1) Department of Biological Science, Kuwait University, Kuwait 2) College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 3) Department of Population Health & Reproduction, University of California - Davis, Davis, CA Degree of Bengalness: A measure of the measure of genomic contribution of Asian Leopard Cats into Bengal breed cats Mona Abdi1, H. Alhaddad1, B. Gandolfi2 R. Grahn3, and L. A. Lyons2 Dataset & Analysis: The idea & Significance • The Bengal breed cats result from hybridizing domestic cats (DOM) and Asian Leopard Cats (ALC). • First generation hybrids can be further crossed to domestic cats and still be considered Bengal cats as long as phenotypic and behavioral characteristics retained (see cat below). • The ALC genomic contribution into registered Bengal cats is usually unknown and likely variable. • Significance of the study: 1. Develop a panel of diagnostic markers to measure ALC genomic contribution in Bengal cats (degree of Bengalness). 2. The panel can be used to study the genetics of the Asian Leopard cat and the ALC-DOM introgression zones in the wild. Dataset: • A total of 2161 cats (from 48 breeds/populations) genotyped using the 63K Feline SNP array were used. • ALC (N = 9) and domestic cats (N = 1765). • Calculate the allele frequency for each marker in each group independently. • Select the markers that are fixed with allele 1 (A1) in ALC and absent in domestic cats or have a minor allele frequency < 0.05. • Evaluate the positions of the selected markers. • Select a subset of the identified markers with near uniform inter-marker distances. Objective 1: Identify diagnostic markers that are fixed for different alleles in the two groups (ALC & DOM) 1. 674 markers were identified as diagnostic markers and they were distributed in all 19 cat chromosomes (Fig. 1a). 2. To avoid markers being in linkage disequilibrium, 287 were selected with an inter-marker distance ~ 5 Mb (Fig. 1b). Fig.1: Distribution of ALC specific markers along cat chromosomes. (a) Relative positions of all markers identified. Many markers are close to one another and may be in linkage disequilibrium. (b) Relative position of a subset of markers from (a) where markers are ~ 5Mb apart. SNP Relative Position (Mb) A1 A2 A3 B1 B2 B3 B4 C1 C2 D1 D2 D3 D4 E1 E2 E3 F1 F2 X 0 25 50 75 100 125 150 175 200 225 250 a. SNP Relative Position (Mb) b. 0 25 50 75 100 125 150 175 200 225 250 Objective 2: Estimate the genomic contribution of ALC in: (1) known pedigree, (2) Bengal breed, (3) Other cat breed Dataset & Analysis: • Diagnostic panel (All: 287 markers, Auto: 262 markers). • ALC-DOM pedigree (N = 98), random Bengal cat (N = 98), and 33 cat breeds (N = 1452). • Calculate % of ALC alleles (% bengalness) in each individual using autosomal markers only. • Using known pedigree samples, estimate range of % bengalness and validate the estimates using pedigree information. Fig. 2: Genomic contribution of ALC. (a). Known pedigree crosses of ALC-DOM. LxD: first generation hybrid. BxL: backcross to ALC. BxD: backcross to DOM. BEN: Bengal cat unknown pedigree (b). Percent bengalness in known pedigree, random bengal cats, and other cat breeds. ALC DOM LxD BxL BxD BEN a. b. Findings: 1. Known ALC-DOM pedigree (Fig. 2a) provides information about theoretical % bengalness. In pedigree samples, theoretical and observed are similar (Fig. 2b, Table 1). 2. Random Bengal cats on average have ~ 7% benglness whereas other cat breeds, combined, exhibit ~ 1% with some variations (Table 1). 3. Proportion of ALC into Bengal cats is unmatched by any of the other breeds with the


4TH PRESS RELEASE 2ND Annual Meeting of A.I.M.S. Cluster The A.I.M.S. Cluster takes its name by its 4 founding projects: Algae4IBD, InnCoCells, MARBLES and SECRETed, which are funded under the same EU topic: FNR-11-2020: Prospecting aquatic and terrestrial natural biological resources for biologically active compounds. The A.I.M.S. Cluster aims to bridge the gaps among the 4 projects by sharing knowledge about common challenges and identifying complementary activities. The projects also effectively cooperate in terms of dissemination activities (social media, conferences and scientific publications) enlarging their audiences’ volume. Sustainable Exploitation of bio-based Compounds Revealed and Engineered from naTural sources COPYRIGHT© Algae-based bio compounds for prevention & treatment of inflammatory bowel disease Bioactive cosmetic ingredients based on underutilized engineered plant resources Marine microbes for drug discovery and sustainable production of fish and crops Engineered strains for industry-driven biosurfactants and siderophores production The SECRETed project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Grant Agreement No. 10100079. This publication reflects only the author’s views and the European Union is not liable for any use that may be made of the information contained therein.


iAtlas Tour of Modules Immune Checkpoint Inhibitor Trials Meet the Team CRI iAtlas is made possible through collaboration between the Cancer Research Institute (cancerresearch.org), Sage Bionetworks (sagebionetworks.org), the Institute for Systems Biology (isbscience.org), and the Vincent Lab (unclineberger.org/vincentlab) at the UNC Lineberger Comprehensive Cancer Center. Our team combines expertise in software design and engineering, bioinformatics, computational biology, immuno-oncology and immunogenomics. David L. Gibbs, Carolina Heimann, Andrew E. Lamb, Dante Bortone, Thomas Yu, Brad Macdonald, Milen Nikolov, Adam J. Taylor, Amy Heiser, Steven P. Vensko II, Susheel Varma, Vesteinn Thorsson, Benjamin G. Vincent Accelerating cancer immunotherapy research with the CRI iAtlas data resource and web portal New IO Data Types CRI iAtlas is grateful for support from the Cancer Research Institute. All references cited here are listed, along with a PDF version of this poster, in Figshare at https://doi.org/10.6084/m9.ﬁgshare.26932027 Immune Landscape of Cancer Amy Heiser Milen Nikolov Thomas Yu Immuno-oncology (IO) is one of the most promising areas of cancer research, with IO-based treatments demonstrating high efﬁcacy within certain cancer types and subsets of patients. The Cancer Research Institute (CRI) iAtlas1 (cri-iatlas.org) is a platform for interactive IO data exploration and discovery, originating in a pan-cancer working group study by the Cancer Genome Atlas (TCGA)2, exploring the relationship between tumors and the immune microenvironment and its impact on patient outcomes. iAtlas provides topic-oriented analysis modules using the R/Shiny4 framework, each generating visualizations and statistics for studying interactions between tumors and the immune microenvironment. Using single cell data we have three new modules, UMAP, Immune Features, and Immunomodulators. Vésteinn Þórsson David Gibbs Carolina Heimann Andrew Lamb Benjamin Vincent We continue to expand the breadth of data in iAtlas, including newly published ICI trials with accompanying outcome data, as well as large-scale cancer -omics datasets such as the Human Tumor Atlas Network11. Dante Bortone Steven Vensko Models and notebooks We aim to make iAtlas a platform that both democratizes analysis for IO researchers and enables contributions from tool developers or data scientists. Everything we build is intended to follow FAIR principles, to advance and accelerate discovery in combating cancer. Expanding iAtlas functionality. Examples of newer modules include (above) a Cytoscape6-powered module showing how receptor-ligand interactions mediate interactions among tumor and immune cells and right iAtlas development has been generously supported by CRI since 2017 iAtlas analysis modules. (left) Interactivity enables users to explore different views or “drill down” into results. (right) List for either large-scale genomics datasets or harmonized ICI study data are driven by ﬂexible features for cohort selection. iAtlas is working hard to ramp up new data ingestion! Among the various data types we host, we've added single cell RNA-seq, with a focus on immuno-oncology studies. In our beta version (in test now), we have six new data sets that come from the Human Tumor Atlas Network (HTAN) and other public resources. Acknowledgement, References & Contact (Above) For ICI datasets with DNA- and RNA-seq data available, the Vincent Lab has developed a workﬂow (using Nextﬂow DSL2) to predict tumor antigens derived from a comprehensive set of genomic sources. The Landscape of Effective Neoantigens Software (LENS)21 workﬂow provides a portable and reproducible process for deriving these data for use in translational applications. In the TCGA study3, we identiﬁed six immune subtypes—associated with differences in somatic aberrations, microenvironment, and survival—that span cancer types and molecular subtypes. For each sample, we characterized the tumor microenvironment in terms of


KEY ART-RESEARCH-EXHIBITION PROJECT • IMAGES OF IDENTITY (2020–21) This project combined the visual arts with interdisciplinary research in the humanities and social sciences, focusing on the question of ‘identity’. To explore this theme, the conference was divided into five thematic panels, each presenting the creative perspectives of five artists exhibiting at the BPA. The exhibition and the accompanying conference ‘Our Everyday Identity’ were part of the interdisciplinary research project ‘The Question of ‘Identity’ in an Interdisciplinary Approach’. Organised by BPA, PUNO and the University of the National Commission in Krakow (UP, Poland). Side events: guided tours of the exhibition with curators, artists’ talks, an international conference and the publication of selected artworks and texts in an academic journal. VIRTUAL GALLERY A Nexus of Artistic Practice and Research Authors: Dr Justyna Gorzkowicz, Email: justyna.gorzkowicz@puno.ac.uk, ORCID: 0000-0003-1139-2137 MA Jarosław Solecki, Email: jaroslaw.solecki@puno.ac.uk, ORCID: 0000-0002-5929-2023 DARIAH Annual Event 2024, Lisbon, Portugal KEY ART PROJECTS • THE DYSTOPIA OF IMITATION (series of artworks by Jarosław Solecki, 2021–23) Supported by Arts Council England, this project evolves from a virtual installation to augmented reality (AR). It features an animated 3D sculpture inspired by Johannes Vermeer’s ‘The Milkmaid’, blending traditional sculptural techniques with digital methods to create a generative AR art object. This project demonstrates the potential of virtual galleries and AR to broaden access to art, foster global collaboration, and democratise the art process. Side events: guided tour of the exhibition with the curator, artistic talk, e-book. • CYPRIAN NORWID’S SKETCHES (2021–23) Featuring sketches by Polish poet and artist Cyprian Norwid, this exhibition underlines the gallery’s commitment to non-commercial activities and its role as a nexus of artistic practice and research. Developed as part of the larger project ‘Norwid in Great Britain’ by PUNO, the Union of Polish Writers Abroad in London, and the University of Warsaw. Side events: guided tour of the exhibition with curators and e-book launch, research element: international conference and post-conference monograph; educational component: online lectures with young students, including presentation of a virtual exhibition, series of short documentary films tracing Norwid’s footsteps in London, telling the story of the poet’s emigrant legacy, closing symposium. INTRODUCTION Blue Point Art Gallery London (BPA) places the arts and humanities at the heart of a technologically evolving society. Our mission is to bridge the gap between artists and researchers, promoting open and accessible knowledge about culture and society. BPA brings together a diverse team skilled in the visual arts, digital technologies and humanities, enabling us to create innovative and interactive projects that engage audiences. Our expertise includes theoretical and methodological research, providing artistic and cultural anthropological context to contemporary activities, and publishing scholarly work. We see digital technology as a powerful tool for exploration and development, tailoring our projects to meet the specific needs of each initiative. This approach values the diversity of research ecosystems and artistic activities, enriching the wider research community. Our gallery serves as a small experimental platform for knowledge exchange, fostering a collaborative and inclusive environment. While our focus is on Polish culture, we aim to provide broad access to knowledge about heritage in an international context. Our practices have the potential for significant impact, advancing the scholarly, artistic and cultural heritage for the public interest. BPA projects are divided into three main types: artistic projects, research- exhibition projects and art-research-exhibition projects. • WAKE-UP CALL (winning posters from the 11


Evaluation of the Types of Farms and Their Effects on the Development of Asthma and Allergies INTRODUCTION The purpose of this study is to determine the factors that are significantly involved in reducing asthma risk in farm environments. CONCLUSION FUTURE IMPLICATIONS Meram Alamoudi1, Shandra Bellinger1, Armando Marull1, Melany Santana1, Felix E. Rivera-Mariani, PhD1 1College of Biomedical Sciences, Larkin University According to the WHO, asthma is the most common non- communicable disease among children with approximately 235 million people suffering worldwide. It has skyrocketed in recent decades, specifically in urban and modernized environments globally. Epidemiological studies have demonstrated that children who grew up in rural areas have less asthma than those in urban environments. This study aims to discuss the various factors that are instrumental in reducing the susceptibility of asthma and allergies in children that were exposed to living on farms in the United States. There have been limited studies comparing asthma risks in children who grew up in farm environments in the U.S. as there aren’t many that have been done nationally in every single state. This poses a problem in attempting to produce a more accurate depiction of the patterns associated with lower asthma rates in children and farm exposure. Figure 2 Showcases the asthma rates of the states with the highest number of farms (Texas), lowest number of farms (Alaska), and a state in the middle (Louisiana). More studies need to be conducted to determine accurate comparisons of asthma-reduction effects with difference types of farms (in example, agricultural farms versus traditional farms). Does the climate the farms are in matter in asthma prevalence? • All research articles reviewed in this study suggest that farms have a positive effect on the development of both allergies and asthma in children. • The Hygiene Hypothesis is a theory suggesting that an environment that is too clean will not expose those in it to enough allergens needed to build their immune system. • The endotoxin that is in farm dust and produced by bacteria is present in most types of farms; allowing farms to act as protective environments against allergy development. • The types of farms reviewed are dairy farms, poultry farms and crop farms, and in all settings, children exposed were less likely to develop allergies as adults. • Data suggest that the exposure to animals on the farm (dairy and poultry farms) help to reduce the risk of allergy and asthma development. • The location (by state) of the farm does not seem to influence the effectiveness of the farm dust as protection, as each study reviewed farms in different states. • Industrialized and traditional farming practices displayed consistent findings however traditional farms had a greater impact. • Asthma rates per state reported by the CDC were compared against the number of farms reported per state; Texas had the most amount of farms and lowest percent with current asthma • Childhood exposure to farms will help decrease the occurrence of allergies and asthma. Figure 1 Figure 2 The following are differences that were present in the various studies reviewed but the relationship between farming and decreased risk of developing Asthma and Allergies is consistent: • Dairy, poultry and crop farms • Location of the farm (different states) • Industrialized vs. traditional farming practices • Exposure to animals on a farm These findings indicate that there is no significance in the type of farm the child is exposed to or the location of the farm. The results denote that the farm dust present will act as protection against the development of asthma and allergies when the child is exposed at a young age. PURPOSE METHODS RESULTS DATA LIMITATIONS Figure 1 Showcases the states with the highest number of farms (Texas), lowest number of farms (Alaska), and a state in the middle (Louisiana).


A Milestone-Based Approach to Monitoring Disease Progression in Parkinson’s Disease Michael C. Brumm,1 Andrew Siderowf,2 Tanya Simuni,3 Elliot Burghardt,1 Chelsea Caspell-Garcia,1 Arthur W. Toga,4 Douglas Galasko,5 Brit Mollenhauer,6,7 Lana M. Chahine,8 Tatiana Foroud,9 Vanessa Arnedo,10 Mark Frasier,10 Alyssa Reimer,10 Caroline Tanner,11 Kathleen Poston,12 Daniel Weintraub,2,13 Samantha J. Hutten,10 Karl Kieburtz,14 Kenneth Marek,15 and Christopher S. Coffey1 1University of Iowa, Iowa City, IA, USA; 2University of Pennsylvania, Philadelphia, PA, USA; 3Northwestern University, Chicago, IL, USA; 4University of Southern California, Los Angeles, CA, USA; 5University of California, San Diego, CA, USA; 6University Medical Center Goettingen, Goettingen, Germany; 7Paracelsus-Elena-Klinik, Kassel, Germany; 8University of Pittsburgh, Pittsburgh, PA, USA; 9Indiana University, Indianapolis, IN, USA; 10The Michael J. Fox Foundation for Parkinson’s Research, New York, NY, USA; 11University of California, San Francisco, CA, USA; 12Stanford University, Stanford, CA, USA; 13Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; 14University of Rochester, Rochester, NY, USA; 15Institute for Neurodegenerative Disorders, New Haven, CT, USA OBJECTIVE RESULTS DESIGN/METHODS Clinical features at baseline that predicted reaching at least one milestone included increasing age (p<0.0001), greater MDS-UPDRS total score (p<0.0001) and greater depression score on the GDS-15 (p=0.0341). Biomarker predictors of reaching a milestone included decreasing DAT SPECT binding (p=0.0043) and CSF lower total alpha-synuclein (p=0.0033). Dopaminergic treatment was not significantly associated with the endpoint (p=0.1639). To assess the frequency of progression to clinically meaningful disease milestones and examine baseline predictors of reaching these milestones in early Parkinson’s disease (PD) using Parkinson Progression Marker Initiative (PPMI) data. CONCLUSIONS Clinically relevant milestones occur frequently within five years of follow-up even in early PD, and are associated with baseline clinical and biological markers, but not significantly associated with dopaminergic treatment. The results of this analysis are relevant for patient selection and outcome assessment in clinical trials. Funding agencies: PPMI – a public-private partnership – is funded by the Michael J. Fox Foundation for Parkinson’s Research funding partners 4D Pharma, Abbvie, Acurex Therapeutics, Allergan, Amathus Therapeutics, ASAP, Avid Radiopharmaceuticals, Bial Biotech, Biogen, BioLegend, Bristol-Myers Squibb, Calico, Celgene, Dacapo Brain Science, Denali, The Edmond J. Safra Foundaiton, GE Healthcare, Genentech, GlaxoSmithKline, Golub Capital, Handl Therapeutics, Insitro, Janssen Neuroscience, Lilly, Lundbeck, Merck, Meso Scale Discovery, Neurocrine Biosciences, Pfizer, Piramal, Prevail, Roche, Sanofi Genzyme, Servier, Takeda, Teva, UCB, Verily, and Voyager Therapeutics. BACKGROUND  Assessment of time to clinically relevant milestones could serve as a composite endpoint in clinical trials and be implemented in trials including patients receiving dopaminergic treatment. We measured 25 milestones across six domains: “walking and balance”; “motor complications”; “cognitive”; “autonomic”; “functional independence”; and “activities of daily living.” Milestones reflected severe manifestations of a given problem (e.g., a score ≥ 3 on relevant MDS-UPDRS items). Progression Milestone Assessment(s) Criteria Walking and Balance Domain Walking and Balance MDS-UPDRS Item 2.12 Response ≥ 3 Freezing MDS-UPDRS Item 2.13 Response ≥ 3 Gait MDS-UPDRS Item 3.10 Response ≥ 3 (ON or OFF) Freezing of Gait MDS-UPDRS Item 3.11 Response = 4 (ON or OFF) Postural Stability MDS-UPDRS Item 3.12 Response ≥ 3 (ON or OFF) Hoehn and Yahr Stage Hoehn and Yahr Stage Response ≥ 4 (ON or OFF) Motor Complications Domain Dyskinesias MDS-UPDRS Items 4.1 and 4.2 Response ≥ 3 (on BOTH) Fluctuations (Functiona


Result 4 – PS-Eu affects surfactant secretion/production and boosts metabolic activity in Sub and ALI samples, while changing cell morphology (TEM) in ALI (increased authophagy and protein aggregation, reduced Mitochondria/ER contacts and lamellar bodies). Sub samples ultrastructure is still under evaluation. No effect on barrier integrity, PS-Eu translocation or cytotoxicity was found. Result 2 – PS-Eu affect acidic organelle activity (NRU) in a dose-dependent manner and are uptaken by A549 grown under standard submerged conditions (culture method A). 600nm * N LD * PS-Eu 50 µg/ml PS-Eu 100 µg/ml 200nm Control LB * PS-Eu 25 µg/ml 200nm 600nm Particle uptake (TEM) Impact of Polystyrene Nanoparticles on Lung Epithelial Barrier Formation and Functionality Sara Michelini, Neža Repar, Ema Kurešepi, Katarina Šimunović, Francesco Barbero, Martin Schicht, Katharina Jüngert, Victor Ganin, Ivana Fenoglio, Friedrich Paulsen, Andreja Erman, Barbara Šetina Batić, Ines Mandič-Mulec, Anita Jemec Kokalj, Damjana Drobne. Background: Micro- and nanoplastics (MNPs) are one of the most widespread pollutants of our time. They can be manufactured in specific sizes for a specific purpose or be released into the environment through the degradation of plastic products. Humans are generally exposed to MNPs via two main routes: food ingestion or inhalation of air. In the latter case, it has already been reported that airborne particles can enter and accumulate in the lower respiratory tract, leading to occupational diseases. This study aims to assess the impact of 274 nm europium-doped polystyrene (PS-Eu) particles on the integrity and functionality of the lung barrier, especially in terms of surfactant production. The presented results were produced both on A549 cells grown in “standard” submerged (Sub) conditions as well as by performing the assays in Air-liquid interface conditions (ALI) using transwells which resemble more closely the real-life settings. Result 3 – Model characterization. Epithelial barrier forms 10 days post seeding. After 17 days ALI-grown A549 produce more surfactants, and have more microvilli than Sub cells. hello@plasticsfate.eu www.plasticsfate.eu plasticsfate Linkedin.com/groups/12519441 PlasticsFatE has received funding from the European Union’s Horizon 2020 Research and Innovation programme, under the Grant Agreement number 965367 Conclusion and outlook: PS-Eu has been found able to increase acidic organelle activity and, in cells grown on transwells, also surfactant production and metabolic activity. Additionally in ALI, which is a more physiological model, TEM analysis revealed that PS-Eu caused a dose-dependent reduction of both LB and mitochondria-ER contacts (structures known to be critically involved in surfactant production/secretion), possibly by inducing autophagy upon uptake. Many LB were in fact found in autophagic vacuoles. Taken together these results may indicate that PS-Eu, upon uptake, are able to affect LB trafficking, vesicle acidification and mitochondria/ER activity causing a dose-dependent reduction of intracellular surfactant production which possibly will affect, at later timepoints, the extracellular surfactant pool, which is up to now not drastically affected with the exception of SP-D and SP-D. Sub samples ultrastructural analysis might shed more light on the mechanisms underlying the shown effects. Acknowledgements: Method images were created with BioRender.com. Figure 2: Impact of different concentrations of PS-Eu on A549 cells in terms of A) cytotoxicity (LDH assay), B) metabolic activity (Resazurin assay), C) protein content (CBB assay) and D) acidic organelles activity (Neutral Red Uptake assay). Particle uptake was confirmed via TEM E). LB, lamellar body; N, nucleus; LD, lipid droplet; asterisk, PS-Eu. Figure 3: Model characterization. A) OT permeability and TEER of A549 cells grown in ALI or submerged conditions on transwells (culture method B). B) Confocal microscopy showing OT barrier for


Betreuung: Prof. Dr.-Ing. Nils Jensen & Prof. Dr. rer. nat. habil. Torsten Sander Vorhaben einer Masterarbeit im Online-Masterstudiengang Medieninformatik Jens Gäbeler Fakultät Informatik ENTWICKLUNG EINER STEUERUNGSKOMPONENTE ZUR PRIORISIERUNG VON AUFTRÄGEN FÜR VERTEILTE WEBCRAWLS Motivation Mithilfe des Open Web Index (OWI) möchte die Open Search Foundation eine europäische Alternative zu den kommerziellen Webindizes der Firmen Google, Microsoft, Baidu und Yandex schaffen. Dieser Index als öffentliche Infrastruktur soll von europäischen Organisationen genutzt werden können, um vielfältige Dienste erstellen und anbieten zu können. Die geplante modulare Bauweise des OWI (siehe Abbildung 1) ermöglicht die Konzentration auf einzelne Aspekte, wie zum Beispiel das in der Masterthesis zu bearbeitende Thema der Priorisierung und Verteilung von Crawlaufträgen. Fragestellung Vor der Erstellung einer Steuerungskomponente zur Priorisierung entstehen die folgenden wissenschaftlichen Fragen: Vorgehensweise Die Masterthesis durchläuft geplant 5 Phasen (siehe Tabelle 1). Davon finden die ersten beiden Phasen parallel statt, die weiteren Phasen laufen konsekutiv. Zeitplanung Der Beginn der Masterarbeit ist der 19.09.2019. Das späteste Abgabedatum ist der 23.07.2020. Dies entspricht einer Bearbeitungszeit von 44 Wochen in Teilzeit. In Abbildung 3 sind die geplanten Arbeitspakete und deren Zeiten dargestellt. Stand der Arbeit Organisatorisch Die Literaturrecherche erweist sich als umfangreicher als während der initialen Planung gedacht. Daher wurde der Zeitplan für die ersten beiden Phasen um zwei Wochen verlängert. Im Gegenzug wird der zeitliche Rahmen der Realisierung gekürzt. Abbildung 3 zeigt die aktuelle Version. Wissenschaftliche Erkenntnisse (Phase 1) Mit der Methode SLR (Systematic Literature Review) werden zu den Forschungsfragen passende wissenschaftliche Arbeiten gesucht, kategorisiert und ausgewertet. Zum aktuellen Stand wurden die folgenden relevanten Arbeiten identifiziert: Des Weiteren wurden die folgenden Grundlagenwerke zur umgebenden Recherche des Themas ermittelt: Technische Bereitstellung (Phase 2) Die OWI Architektur wurde analysiert und folgender Einhängepunkt der zu entwickelnden Steuerungskomponente identifiziert: Für die Realisierung wird Python und das Microframework Flask verwendet. Python eignet sich durch die umfangreichen Funktionen seiner Standardbibliothek und durch eine Vielzahl an Bibliotheken zur Berechnung (z.B. Numpy, SciPy), Datenhaltung (z.B. Pandas) und bei Bedarf Künstlicher Intelligenz (z.B. SciKit, Keras, TensorFlow). Das Microframework Flask eignet sich sehr für die Erstellung einer Anwendung, die über eine REST API zur Verfügung gestellt wird. Phase Methode Ziel 1. Akademische Analyse SLR & Kriterienaufnahme Katalog mögl. Priorisierungs- und Evaluationstechniken 2. Techn. Vorbereitung Bereitstellung der techn. Umgebung Erstellung einer Minimalversion 3. Entwurf Umsetzung auf Basis von 1) Funktionsentwurf & Prozessentwurf 4. Realisierung Umsetzung auf Basis von 3) Prototyp 5. Evaluation Vergleich Ranking [1] Huss, N.; Lewandowski, D.; Sander-Beuermann Wolfgang; Ude, A.: Proposal for an Open Web Index, Hannover 2017. https://openwebindex.eu/wp-content/uploads/2019/01/Open_Web_Index_proposal.pdf, abgerufen am 09. August 2019 Quelle Abbildung 1: Modularer Aufbau der Dienste des OWI [1] 1. Welche Arten der Priorisierung von Crawler-Warteschlangen gibt es? 4. Welche Vergleiche gibt es und wie erfolgt die Evaluation? 2. Gibt es Priorisierungstechniken explizit für verteilte Crawler? 3. Welche geotopologische Ansätze gibt es bereits? Abbildung 2: Forschungsfragen Tabelle 1: Phasen der Masterthesis Jul 20 Okt 19 Nov 19 Dez 19 Jan 20 Feb 20 Mrz 20 Start Abgabe Apr 20 Mai 20 Jun 20 Sep 19 4. Realisierung 5. Evaluation 6. Schriftl. Ausarbeitung 7. Projektmanagement 1. Analyse 3. Entwurf 2. Admin. Vorbereitung Puffer M3 M4 M5 M1 M2 OSS Abbildung 3: Zeitplanung der Masterthesis Abbildung 4: Verortung der Steuerun


OCL 2.0 Reference Card Author: Fernando Brito e Abreu (fba@iscte-iul.pt) Affiliation: ISTAR-IUL / ISCTE-IUL Collection type operations Set Bag OrderedSet Sequence Description collection->size(): Integer V V V V Number of elements in the self collection collection->isEmpty(): Boolean V V V V True if the self collection is empty collection->notEmpty(): Boolean V V V V True if the self collection is not empty collection1 = collection2 : Boolean V V V V True if the first collection is equal to the second collection collection1 <> collection2 : Boolean V V V V True if the first collection is different to the second collection collection->isUnique(expr: T): Boolean V V V V True if the argument expression is unique within the self collection collection->select(expr: Boolean): Collection(T) V V V V Elements of the self collection that match the argument condition collection->reject(expr: Boolean): Collection(T) V V V V Elements of the self collection that do not match the argument condition collection->sortedBy(OclBasicType): Sequence(T) V V V V Elements of the self collection sorted by the argument expression collection->collect(expr: T): Collection(T) V V V V Flattened collection of expression values obtained from the self collection members collection->collectNested(expr: T): Collection(T) V V V V Nested collection of expression values obtained from the self collection members collection->iterate(x:I [; acc:J=init]|expr: T|Collection(T)): T|Collection(T) V V V V Iterator that allows defining its logic collection->forAll(expr: Boolean): Boolean V V V V True if the argument expression holds for all members of the self collection collection->exists(expr: Boolean): Boolean V V V V True if the argument holds for at least one member of the self collection collection->one(expr: Boolean): Boolean V V V V True if the argument holds for only one member of the self collection collection->includes(element: T): Boolean V V V V True if the argument is part of the self collection collection->excludes(element: T): Boolean V V V V True if the argument is not part of the self collection collection->includesAll(collection: Collection(T)): Boolean V V V V True if all members of the argument collection belong to the self collection collection->excludesAll(collection: Collection(T)): Boolean V V V V True if none of the members of the argument collection belong to the self collection collection->including(element: T): Collection(T) V V V V The self collection with the argument added to it collection->excluding(element: T): Collection(T) V V V V The self collection with the argument removed from it collection->union(collection: Collection(T)): Collection(T) V V V V The union of the self collection with the argument collection collection->intersection(collection: Set(T) | Bag(T)): Set(T) | Bag(T) V V The intersection of the self collection with the argument collection collection1 - collection2: Set(T) V The first set excluding all elements of the second set collection->symmetricDifference(collection: Set(T)): Set(T) V Union of the self collection with the argument collection, minus their intersection collection->prepend(element: T): OrderedSet(T) | Sequence(T) V V The self (ordered) collection prepended with the argument collection->insertAt(pos:Integer,element:T):OrderedSet(T)|Sequence(T) V V The self (ordered) collection with the argument inserted at the position collection->reverse(): OrderedSet(T) | Sequence(T) V V The self (ordered) collection in reverse order collection->append(element: T): OrderedSet(T) | Sequence(T) V V The self (ordered) collection appended with the argument collection->flatten(): Collection(T) V V V V The self collection flattened; only produces effect if the self collection is nested collection->sum(): Integer | Real V V V V The addition of all elements of an Integer or Real collection collection->max(): Integer | Real V V V V The largest element of an Integer or Real collection collection->min(): Integer | Real V V V V The smal


Amphipods Crabs Barnacles Brine shrimp Copepods Amphipods Antennae Head Thorax Telson Abdomen They are considered "bees of the sea" for pollinating the seagrass ﬂowers Design & illustration: Alberto Guerra Content consulting: María Muciño Carlos Paz In the world there are: and in Mexico: from the greek “amphi”: both sides of and “podos”: foot (Feet on both sides) Coordinación: Diana Ugalde and Nuno Simões ±10,000 species The largest is 29 cm The ﬁrst 4 feet facing backward The last 3 feet facing forward They parasitize dolphins and whales Intertidal zone Beaches Buoys Seaweeds Boat hulls Sand or mud tubes Inside burrows live on the water bottom (marine or freshwater) Seagrasses Sea stars Sponges Tunicates Hydrozoans Vertical migration in the water column 1 mm You can ﬁnd them in the deepest place on the earth: The Mariana Trench They live in: Crustaceans Gammarids Feeding: Caprellids Hyperiids Talitrids Cyamids 0 m ±11,000 m Are the prey of: they are essential in the food chains of ﬁsh, mollusks, and birds Some adhere to ﬁsh gills to get food. Seaweeds Detritivores and Scavengers Filter-feeders Herbivores ±950 species The female has a "ventral brood pouch" where the eggs develop. Female caprellids protect hatched juveniles on their bodies and gammarids in burrows. (skeleton shrimp) (sand ﬂeas) Fish Shrimp Polychaetes and nemerteans worms They are the favorite food of seahorses! ♀ ♂ Life cycle Corales Corals