CancellationTools: All-in-One Software to Collect and Analyse Multi-Target Visual Search Data Edwin S. Dalmaijera, Stefan van der Stigchelb, Tanja C.W. Nijboerb,c, Tim H.W. Cornelissenb, & Masud Husaina,d a Experimental Psychology, University of Oxford, b Helmholtz Institute, Utrecht University, c Rudolf Magnus Institute & Rehabilitation Centre De Hoogstraat, University Medical Centre Utrecht, d Nuﬃeld Dept. of Clinical Neuroscience, University of Oxford open source high-quality data visualisation complete and automated analysis run all cancellation tasks download Customizable test properties: - input type (touch screen or mouse) - cancellation marking visibility - target and background colour - target and distractor properties Or scan your own task Scan the QR code, or visit our website: www.CancellationTools.org edwin.dalmaijer@psy.ox.ac.uk CancellationTools is released under the GNU General Public License, ensuring it will always be free and open to everyone. The source code is available from GitHub: https://github.com/esdalmaijer/CancellationTools partners and sponsors @esdalmaijer CancellationTools was developed at the University of Oxford, in collaboration with Utrecht University. It is supported through the Individualised Diagnostics & Rehabilitation of Attention Disorders (INDIREA) project, sponsored by the European Commission. For more information, please visit www.indirea.eu. neglect centre of cancellation omissions per half working memory immediate revisits delayed revisits search organisation inter-cancellation distance inter-cancellation angle path intersection rate best R performance inter-cancellation time search speed time-on-task Q score Analyse individual or group data with the click of a button. The fully automated process calculates almost every known index of cancellation performance (summarized below). The outcome is stored in an A4-sized PDF (useful for clinical testing) and a machine-readable text ﬁle (directly importable into spreadsheet editors, SPSS, or a programming language). Search organisation can be indexed by the standardised angle and the best R (correlation between horizontal/vertical position of a cancelled target and its cancellation rank number). Heatmap averages provide a visualisation of biases of spatial attention in a sample. Plot intensities are scaled to the theoretical task maximum, and comparable across individuals. healthy (N = 10) neglect (N = 10) cancellations omissions A cancellation path gives a full account of a patient's search behaviour. A superimposed heatplot (cancellations) reveals biases of spatial attention. best R = 0.88 std. angle = 1.00 std. distance = 1.00 M distance = 100 px best R = 0.88 std. angle = 1.00 std. distance = 1.00 M distance = 300 px We collected and devised indices that are independent of task properties, to allow for performance comparisons across tasks. supported platforms Currently, a standalone version is available for Windows, and a version for Android is on its way. We are also planning on creating versions for Mac OS X and Linux. If you can't wait for those, it is perfectly possible to run the CancellationTools code from source using Python. Additionally, you can run tasks from our website, www.cancellationtools.org, although you will still need a standalone version to analyse the data. Cancellation tests require participants to search for and cross out targets (circles with an opening on top, in the example below), while ignoring distractor stimuli.


Make your list, check it twice ✦ Erin Clary, Digital Research Alliance of Canada ✦ Beth Knazook, Digital Repository of Ireland ✦ Mikala Narlock, Data Curation Network Curatorial preservation checklist for repositories Introduction Generalist data repositories that accept a variety of dataset submissions will require comprehensive information about a dataset's creation, relevance, and long-term value to support informed preservation decisions. To enable structured and documented conversations between preservationists, depositors, and data curators, we have developed and refined a checklist to aid long-term preservation decisions. V2 published: doi.org/10.5281/zenodo.11371489 Checklist How to Use it Contact info Erin.Clary@alliancecan.ca b.knazook@ria.ie mnarlock@umn.edu iPRES 2024 Section 1: Preservation Intent Section 2: Ease of Preservation Researcher intent Cost Relevance to mission Rights and restrictions Value to communities Context: documentation Uniqueness Content: file formats Each ‘yes’ answer builds a more robust rationale for preservation. →There are no fixed number of ‘yes’ answers that make the decision.← At the end of the checklist, the curator makes a preservation recommendation: ❏ Yes / No These decisions can easily be reviewed in the future. Try it out! - What worked well? - What is missing? - Let us know what you think: forms.gle/5XUhRykdWCzj3Cqe7


Extensible and Community-Driven Thermodynamics, Transport, and Chemical Kinetics Modeling with Cantera: Expanding to Diverse Scientific Domains COLORADO SCHOOL OF Jongyoon Bae, Bang-Shiuh Chen, Steven DeCaluwe, Franklin Goldsmith, China Hagström, Gregory Jackson, Robert Kee, Gandhali Kogekar, Daniel Korff, Kyle Niemeyer, Sun Su, Raymond Speth, Anthony Walker, Bryan Weber, Richard West, Chao Xu, and Xinyu Zhao - Cantera objects/classes represent: - Phases of matter (solids, liquids, gases, interfaces) - Functions to calculate properties and rates - Solvers for chemical equilibrium, time-dependent 0-D systems (reactor networks), and steady-state 1-D reacting systems (flames) - Core library written in C++ with interfaces for user applications available in Python, C++, MATLAB, C, and Fortran 90 - Cantera’s object-oriented architecture enables efficient development of new models This work is supported by the National Science Foundation under Grant Nos. 1931584, 1931391, 1931539, 1931592, 1931397, and 1931389. New developments with NSF funding - YAML-based input file format - Provides easy access to user-defined data fields - YAML files can be generated from dynamically- generated/modified Cantera objects (serialization) - Enables efficient interoperability with other tools - Extensibility of Cantera C++ models using Python classes - Allows users to extend existing C++ models with Python code - Enables rapid prototyping and easy distribution of new scientific models - New reaction rate models - Blowers-Masel parameterization, which captures sensitivity to enthalpy of reaction - Plasma reactions with distinct electron and gas temperatures - New thermodynamic models: - Peng-Robinson equation of state for real gases - Plasma phases including calculation of the electron energy distribution function - Non-ideal surface phases with coverage-dependent thermo - Adaptive preconditioning - Accelerate integration of kinetic models with 1000s of species - New user interfaces being developed for Julia and .NET/C# - Implemented using source code generation to simplify maintenance of repetitive wrapper code - Simpler installation options - pip package for the Cantera Python module - Workshops & community engagement - Established Cantera Scientific Advisory Board with representatives from academia, industry, and government - National Combustion Meeting Workshop (May 2021, virtual) - Combustion Symposium Workshop (July 2022, Vancouver) - ACS National Meeting Workshop (August 2022, Chicago) Cantera is an open-source suite of tools for solving problems involving chemical kinetics, thermodynamics, and transport processes. Cantera Input File (YAML) Computational Model species: - name: CH3 composition: {C: 1, H: 3} thermo: model: NASA7 temperature-ranges: [300.0, 1000.0, 5000.0] data: - [1.051551, 0.0259919, 2.380054e-06, ...] - [7.702698, 0.0160442, -1.9609569e-08, ...] transport: ... - name: CH2O composition: {C: 1, H: 2, O: 1} ... reactions: - equation: H + CH3 (+M) <=> CH4 (+M) type: falloff low-P-rate-constant: {A: 2.6e+33, b: -4.8, Ea: 2440} high-P-rate-constant: {A: 1.4e+16, b: -0.5, Ea: 536} Troe: {A: 0.783, T3: 74.0, T1: 2941.0, T2: 6964.0} efficiencies: {H2: 2.0, H2O: 6.0, ...} - equation: O + CH3 <=> H + CH2O # Reaction 10 rate-constant: {A: 5.06e+13, b: 0.0, Ea: 0.0} - equation: H + CH2CO <=> CH3 + CO # Reaction 81 rate-constant: {A: 1.13e+13, b: 0.0, Ea: 3428.0} ... phases: - name: flamegas thermo: ideal-gas kinetics: gas transport: mixture-averaged Goals of this project Extend Cantera’s capabilities - Support scientific discovery and technology development in energy storage & conversion, chemical processing, and atmospheric chemistry Expand Cantera’s user base - Outreach to critical fields including electrochemistry, heterogeneous catalysis, and atmospheric chemistry Broaden participation in the software’s development and management - Improve Cantera’s sustainability and usability SUNDIALS (ODE solver) Eigen (linear algebra) libyaml-cpp (in


Supported by: Paper citation: Payne, L.J., Todeschini, T.C., Wu, Y., Perry, B.J., Ronson, C.W., Fineran, P.C., Nobrega, F.L., Jackson, S.A. (2021) Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types. Nucleic Acids Research, 49, 10868-10878. • We have developed PADLOC, a tool to identify many widespread defence systems, including recently discovered systems. • Using PADLOC, we have discovered additional proteins frequently associated with several known defence systems and classified these into new system subtypes. • We have identified several phages that are inhibited by these new defence systems. • PADLOC is available as a standalone package (https://github.com/padlocbio/ padloc) and as a webserver (https://padloc.otago.ac.nz), which allow analysis of user-supplied genomes. Summary • When expressed heterologously in E. coli, the new systems limit phage infection. • Several phages exhibited reduced ability to form plaques on bacterial lawns (efficiency of plaquing; EOP) and collapse of liquid culture was prevented at a multiplicity of infection (MOI) below 0.1. New systems provide defence against phage infection Clone defence system Transform into E. coli Infect with phage Measure infection efficency Control Zorya III Hachiman II Lamassu II EOP relative to control (%) Control Zorya III Hachiman II Lamassu II Phage T1 T3 T4 T7 LambdaVir PVP-SE1 0 20 40 60 80 100 120 *** * *** ** ** * ** * ** ********* 0 300 600 900 0.0 0.5 1.0 1.5 2.0 2.5 MOI = 0 OD600 0 300 600 900 MOI = 0.01 Time (min) 0 300 600 900 MOI = 0.1 strong weak Identify loci with at least two genes of the same system Cluster genes in the neighbourhood of defence loci Assess the frequency of association Genomes 1 2 3 n Select novel variants with frequently associated genes 36,395 loci 41,470 genomes 73,063 clusters 225,898 genes 6 variants + 1 new system 730,430 associations ThsA ThsB HamA HamB PtuA PtuB ZorA1 ZorB1 LmuA LmuB ThsC HamC LmuC DruE2 DruF2 PtuC ZorG ZorF DruL Canonical Associated Association frequency 0.5 0.75 1.0 • By analysing these associations, we discovered several new system subtypes and a novel system comprising a Helicase, Methylase and ATPase. • To demonstrate how PADLOC can be used to address biological questions, we systematically identified proteins frequently associated with known systems. Identification and classification of new defence systems • Shown is a subset of all defence systems identified with PADLOC in ~200,000 RefSeq genomes. • More than 100 types of defence systems can currently be identified using PADLOC, including CRISPR-Cas, Abi, and many recently discovered systems. 0 2.5 5 7.5 >10 Average percentage of genomes in each species encoding a system Bacteria Archaea 10 1 1 1 1 6 4 4 6 1 2 1 2 2 3 2 1 6 1 15 5 1 12 3 8 2 16 5 3 14 5 9 3 5 5 3 3 5 11 2 2 3 1 2 12 3 1 4 1 1 7 7 1 1 12 14 1 1 4 21 17 9 17 34 13 3 3 9 1 2 1 21 8 2 4 2 1 22 7 4 5 1 2 5 5 16 5 2 7 5 5 20 8 1 2 4 6 4 1 1 13 2 1 1 1 2 15 3 2 2 8 5 24 1 6 3 15 6 10 3 1 2 2 3 3 1 8 1 31 1 8 1 1 13 13 13 3 8 3 19 2 3 9 7 1 2 1 2 17 7 6 4 1 1 13 3 3 11 7 2 7 4 3 2 4 5 3 36 5 14 14 8 8 3 1 2 1 1 1 1 16 4 1 4 2 5 1 3 4 3 8 10 1 8 4 3 1 1 16 7 1 5 3 10 6 7 12 9 13 1 1 13 1 2 2 2 16 11 11 5 2 6 9 4 36 20 15 2 9 3 2 1 16 6 3 3 3 12 1 5 6 9 3 6 3 22 22 25 1 1 9 5 5 10 1 5 37 5 3 5 1 6 12 4 5 4 32 4 11 1 4 7 15 29 38 17 4 4 9 10 12 4 6 59 19 2 1 13 6 4 17 12 1 12 12 6 6 12 12 12 11 5 3 2 3 10 12 12 6 3 15 9 21 11 7 3 4 1 1 1 3 1 20 7 1 3 4 3 1 16 1 6 3 1 8 1 1 5 3 11 4 2 2 6 9 2 3 1 4 4 3 11 5 3 5 12 10 3 6 2 13 18 1 3 6 18 14 8 2 2 2 8 2 2 12 4 4 Thermoproteota Thermoplasmatota Methanobacteriota Halobacteriota Verrucomicrobiota_A Verrucomicrobiota Thermotogota Synergistota Spirochaetota Proteobacteria Planctomycetota Patescibacteria Nitrospirota Myxococcota Marinisomatota Fusobacteriota Firmicutes_F Firmicutes_E Firmicutes_C Firmicutes_B Firmicutes_A Firmicutes Fibrobacterota Desulfobacterota Deinococcota Deferr


Searching for Superhump-like variations on Cata- clysmic Variables using VVV and VVVx data Lagos, Denisse1 & Barría, Daniela. Bachelor’s Degree in Astronomy, Universidad Central, Coquimbo, Chile 1denisse.lagos@alumnos.ucentral.cl Abstract At this work, we explore the presence of Superhumps(SHs) and SHs-like variations at infrared (IR) wavelengths in cataclysmic variable stars (CVs), specifically in Dwarf Nova and Classical Nova types. SHs – periodic photometric oscillations that are slightly shifted from the orbital period (Po) – are usually seen during superoutbursts and are linked to instabilities in close binary systems’s accretion disks. Previous studies have mainly studied SHs in optical bands, so this study focuses on detecting them in the IR. Using light curves from the VVV/x project and the VIVA catalogue, 140 CV systems were identified, and 85 of them were analyzed so far, for frequency detection via periodogram analysis using Period04. Although significant frequencies were detected in the periodograms, none of them corresponds strictly with a SH period. However, at some systems, we have found SHs-like variations. Further studies using the PDM technique will be conducted in the near future. Introduction CVs are a type of close binary systems, where a white dwarf (WD-primary star) pulls ma- terial from a main-sequence companion (sec- ondary star) through an accretion disk (Fig.1 and Fig.2). This, driven by viscosity, loss orbital energy as gas spirals toward the WD, emitting radiation that contributes to the total luminos- ity of the system (Warner, 1995). Light curves reveal changes in a star’s brightness over time and for binary systems they often show dips due to the orbital motion. Additional photometric variabilities, known as superhumps (SHs), might appear in the light curves of CVs as a result of instabilities in the accretion disk (Bruch, et al. 2022, 2023). SHs come in two types: positive SHs, with a period slightly longer than the Po, and negative SHs, with a slightly shorter period. We used 85 CV light curves retrieved from the VVV Survey (Minniti et al. 2009) database at band Ks, to perform a time series analysis us- ing Period04a.To our knowledge, SHs have not been investigated in the IR and this is the main motivation of this work. awww.period04.net Data Analysis We used the VIVA catalogue (Ferreira Lopes et al. 2020) to select 140 CVs (Dwarf Nova and Nova systems) which have been previously studied at visible wavelengths. Ks band light curves for these targets, were downloaded from the VSA-VISTA Science Archivea. A time series analysis was carried out using the software Pe- riod04 in order to identify significant frequencies via periodograms. ahttp://vsa.roe.ac.uk/ Figures Fig.1: An schematic view of a CV system. Fig.2: An accretion disk illustration. Results System ID515472646464 The VVV/DR5 Ks light curve of this CV shows magni- tude fluctuations between 13.5 and 14.1, reflecting typi- cal brightness variations for such systems (see right up- per panel). In the periodogram (bottom panel), a signif- icant peak appears at a frequency of ∼7.1 d−1, with a SNR exceeding 4σ. This periodicity corresponds to the Po according to previous analysis (Ferreira Lopes et al. 2020). The table (right lower panel) list the significant frequencies, amplitudes and SNR found in Period04. System ID515600867128 This CV displays a Ks light curve with magnitude variations between 10.0 and 12.5, reflecting brightness changes typical for these systems. In the periodogram, a significant peak appears at a frequency of ∼1 d−1, with a SNR exceeding 4σ. This finding is slightly higher than the Po reported in the VIVA catalogue and thus we consider that this frequency corresponds to a SH-like variation. System ID515845503587 In this system, the light curve shows magnitude vari- ability between 11.5 and 14.5, reflecting the system’s in- trinsic orbital motion. The periodogram displays a sig- nificant peak at a frequency near 0.0015 d−1


ULRI As a leading independent safety science research organization with global reach, we explore both the benefits and risks of today’s technologies and pursue answers to socially relevant questions related to public safety. ULSE As a global, nonprofit standards development organization, we collaborate with experts around the world and translate scientific discoveries into standards and policies that have the power to make a systemic impact on public safety. Overview of current research locations On the development of a competency-based approach to research safety training Process Educational Influence Paulo Freire (1921 – 1997) was an influential educator and philosopher. Freire’s ideas challenged hierarchal education models, placing the student and teacher as equals rather than passive recipients. Freire’s concept of critical dialog emphasized the role of conversation in learner engagement, individual application, and empowerment. Freire’s theories help to find common ground and are easily adapted in health and safety management, independent of prior experience or existing knowledge. Further reading: Harris DB, Roter DL. Profound Love and Dialogue: Paulo Freire and Liberation Education. Health Lit Res Pract. 2024 Jul;8(3): e118-e120. doi: 10.3928/24748307-20240613-02. Epub 2024 Jul 5. PMID: 38979815; PMCID: PMC11230641. Outcomes • The delivery time is two to three hours, delivered over three to four sessions. • Standardized PPE, supplies, and services can be ordered directly through HSE, thus eliminating approval barriers and payment issues. • Teaching sessions were aligned with shipping large packages of safety supplies to each institute to help get everyone started. Evaluation • Administration of a single written knowledge test based on objectives • Observation of lab practices and peer-to-peer interaction. • Participant feedback, both formal and informal Evolution Transform classroom content into a multimedia course. Supplement online content with periodic in-service training. Remain focused on competencies in the lab and engagement in the hazard and risk assessment process. Presented at Working on Safety BUILDING A RESILIENT FUTURE Towards sustainable safety in a rapidly changing world 22 – 25 September 2024, Dresden, Germany ©2024 Underwriters Laboratories Inc. ©2024 ULSE Inc. Engage Scientists • Develop a conversational style focusing on processes, concepts, and critical facts. • Seek consensus on the role of safety in their work and discuss stop work authority. • Generate a syllabus of standard and specialized knowledge tied to course objectives. • Observe interactions of randomly assembled groups of participants during small-group exercises. Identify leaders. Define Expectations Four pillars to build upon, stated in behavioral terms, are woven into the culture and practices of each institute. Module I | Assessing Hazards & Determining Risks Goal: to develop common standards of care for laboratory safety at ULRI and engage in continuous improvement to protect individuals, one another, public health & the environment. After you participate in today’s program, you should be able to: • Outline the basic elements of risk management. • Define the essential elements in a hazard and risk assessment. • Identify so-called Y Factors that can exacerbate or mitigate the inherent hazards of a hazardous chemical in an experiment. • List the critical information found on a chemical container. • Name where you can find additional information when assessing potential hazards. • Describe the “Hierarchy of Controls” and the three most essential elements in research safety. • Given updated Safety Data Sheets and other suggested references, work in small groups to conduct a basic hazard and risk assessment for different classes of chemicals. Present and discuss your work with your colleagues to discuss. Module II | Controlling Outcomes & Preparing for Emergencies After you participate in today’s program, you should be able to: • List the


Introduction During the Covid-19 epidemic, one of the biggest common recurring global issues has been the ability to perform mass testing of populations, addressing both the dual needs of public health reporting (statistical) and private citizen privacy protection. Materials and methods Research was conducted to determine current methods of reporting and limitations of these current methods, application of new privacy enhancing technologies and self sovereign identity impact of self reporting and means of both authenticating self reporting and binding an identity to tests and subjects in a secure and privacy preserving manner. Results Conclusions Current centralized reporting addresses public health reporting. However, no easy way for citizen to share results with a third party and control who sees these results. Use of ”self sovereign” identity can enable a citizen to selectively share information to a third party. New forms of zero knowledge proofs that work with blockchains – ZKSnarks, can be used to both provide privacy protection and home testing validation. Stephen Holmes, PGR FEPS Computer Science, Surrey University s.a.holmes@surrey.ac.uk Citizen reporting and privacy protection in a post Covid-19 world Acknowledgments Thank you to Simons institute at UC Berkeley for enabling me to participate in Lattice cryptography bootcamp where I was introduced to the full capabilities of lattice-based cryptography. Zero Knowledge Proof conference – At home edition (5 weeks in May 2020) to enable participation in Zero Knowledge Proofs standardization activities. My PhD supervisor: Kaitai Liang, who has encouraged me to investigate what was a detour from my current research, applying this to the Covid testing challenges. Literature cited Short Non-interactive Zero-Knowledge Proofs, Jens Groth, University College London https://www.iacr.org/archive/asiacrypt2010/6477343/6477343.pdf Shafi Goldwasser, Silvio Micali, and Charles Rackoff. The knowledge complexity of interactive proofs. SIAM Journal of Computing, 18(1):186–208, 1989. Bitcoin: A Peer-to-Peer Electronic Cash System, Satoshi Nakamoto ZoKrates - Scalable Privacy-Preserving Off-Chain Computations July 2018 DOI: 10.1109/Cybermatics_2018.2018.00199 Distributed Auditing Proofs of Liabilities, Konstantinos Chalkias, 2020, https://eprint.iacr.org/2020/468.pdf , Further information The project is currently under active development with a view to commercialise this research. Currently in discussion to include this with other Covid reporting protocols and applications. Today Future Traditional health care systems with health care professionals involvement Data is recorded on blockchain/ or Distributed ledger. Result is off-chain so can be deleted Reporting not optimized for speed Multiple data stores to interrogate to get statistical snapshot Blockchain enables authorities to automatically collect statistical data Identity is explicit government issued identity Identities are pseudo anonymous Can be part of Self Sovereign identity. Citizen needs to request certificate from health care professionals. Citizen generates proof on request and shares proof with third party. Can specify expiry date and identity of receiving third party. Overview The starting point for this research was an investigation of how privacy may be enhanced through the application of zero knowledge proofs to address the issue of how to empower a citizen to be in control of their Covid19 test results. Given the ongoing research on immunity passports and the development of home testing kits, the biggest problem appeared to be – How do you prove that you took a test to a third party without compromising an individual’s privacy? What became apparent in the first stage of Investigation was that the home testing cassettes were designed to be mass produced an anonymous. However, without the involvement of a medical health professional there is no easy way to prove you took the test and prove what the results were to a thir


Development of a New Algorithm and Scoring Metric for the Evaluation of Scientific Conference Impact LAUDANO, JBA, HONG, SA, WEI, GA, SKIRBE, PA, MATHEIS, RB AMEDMEME LLC, NEW YORK, NY BCELGENE CORPORATION, SUMMIT, NJ The Authors would like to thank Mr. Won Kim, Mr. Siddhartha Naithani and Mr. Jonathan Kendall for the expert assistance in data collection and interpretation. We would also like thank Mr. Jeff DeGeorgia for his creative direction in the development of this poster. 1. Higgins C, Horner A, Wassef-Birosik L, D’Irio S. Integrating Measures of Journal Impact Provides dditional &nsihts in QcientiÚc 4iterature "ap nalÐses. Jresented at the ȀȂth nnual Meetin of &QMJJȫ MaÐ ȀȶȂȫ ȁǿȀȆȫ ;ational %arworȡ M. Joster ȥȈ. ȁ. "arÚeld . Vhe %istorÐ and Meanin of the Journal &¥pact !actor. JM. ȁǿǿȅȫȁȈȄȲȀȳȠȈǿȶȈȂ. Ȃ. okku Mȡ Qridharan 2ȡ MaeeÍ J. Manuscript Qtrenth !inder VoolȠ n id in eter¥inin Jotential Journal cceptance. Jresented at the ȀȀth nnual Meetin of &QMJJȫ pril ȁȆȶȁȈȡ ȁǿȀȄȫ rlintonȡ b. Joster ȥȀȈ. 4. %irsch J. n index to ·uantifÐ an indiÍidualɀs scientiÚc research output. Jroceedins of the ;ational cade¥Ð of Qciences of the Ynited Qtates of ¥erica. ȁǿǿȄȫȀǿȁȲȃȅȳȠȀȅȄȅȈȶȀȅȄȆȁ. Ȅ. Qan !rancisco eclaration on Mesearch ssess¥ent Ȳ@Mȳ. nnual Meetin of Vhe ¥erican QocietÐ for ell ioloÐ ȲQȳȡece¥wer Ȁȅȡ ȁǿȀȁȡ in Qan !ranciscoȡ . httpsȠȬȬsfdora.orȬ ȅ. Med¥e¥e atawase. JroprietarÐ datawase of puwlished ¥edical science. Ȇ. allawaÐ . Juwlishin elite turns aainst i¥pact factor. ;ature. ȁǿȀȅȫȄȂȄȠȁȀǿȵȁȀȀ. 8. Vi¥e to re¥odel the ournal i¥pact factor.Ȱditorialȱ.;ature.ȁǿȀȅȄȂȄȠȃȅȅ. Ȉ. Vhe uropean ssociation of Qcience ditors ȲQȳ Qtate¥ent on &nappropriate Yse of &¥pact !actors. MetrieÍed ȁǿȀȇȶǿȀȶȀȈ. Dr. Joseph B. Laudano, Dr. Saman Hong, Mr. George Wei and Mr. Paul Skirbe are employees of Medmeme LLC, New York, NY. Dr. Robert Matheis is an employee of Celgene Corporation, Summit, NJ. No animals were harmed in the production of this poster. Jresented at the ȁnd nnual Meetin of Vhe Medical ffairs Jrofessional QocietÐ ȲMJQȳ !ewruarÐ ȁȄȶȁȆȡ ȁǿȀȇȡ Mia¥i !loridaȡ YQ. Please address questions and requests for reprints to Dr. Joseph B. Laudano at J.Laudano@Medmeme.com QtudÐ !unded wÐ Med¥e¥e 44ȡ ;ew eorkȡ ;e. ACKNOWLEDGEMENTS REFERENCES AUTHOR DISCLOSURE CHALLENGE/PROBLEM • Selecting the best and most appropriate scientific conference for the submission of research continues to be challenging for Medical Affairs Professionals (MAPs). While useful Scientometrics for the submission of manuscripts to journals are well established, there currently are no formal metrics for the selection of scientific conferences. • Creation of a scientific conference impact assessment tool has the potential to heighten impact of dissemination of evidence in scientific medical forums • Traditionally, we assume that conferences with the highest attendance and the highest volume of poster presentations within a selected field are those held in higher esteem for abstract submission, potentially having more “weight” or “reach”.1 • For journal selection, MAPs typically make their decisions using a number of parameters: • Impact metrics (Impact Factor, Eigenfactor, SCImago Journal Rank Factor, etc.) are well established citation-based indicators of journal impact.2 • Targeting tools for journals focusing on several different Article- Level Metrics (ALMs) may also be used as a predictor for manuscript acceptance.3 • Author metrics which measure a scientist’s productivity and citation impact (h-index) are also generally employed for study/author selection and the calibre of journals.4 • Based on an unmet need for relevant, timely and accurate metrics for the selection of scientific conferences and a “call” for a shift toward assessment of journal impact based on up-to-date ALMs vs. publication metrics (citations)5, we decided to develop a new algorithm and ranking method for the evaluation of scientific conference i


Simulating Protoplanetary Disk Ices How to observe ices in disks. Absorption features in the continuum from the central star and warm inner disk. Only seen in edge-on disks. Absorption features in the continuum from a star behind the disk. Albedo features in scattered light from the disk surface. Emission features in the far-IR. Nick Ballering1, Ilse Cleeves1, and Dana Anderson2 1University of Virginia, 2Carnegie Earth and Planets Laboratory Why simulate ice features? Ices are distributed heterogeneously throughout a disk, and ice observations cannot uniformly probe all regions of a disk. Forward models can connect observable features to the underlying distribution of disk ices. Methodology Use a gas-grain chemical evolution model to derive the abundance distributions of H2O, CO, CO2, CH3OH, CH4, and NH3 ices in a disk. Group model cells into “zones” of similar ice composition using a k-means algorithm, then compute the opacity for each zone. Use the radiative transfer code RADMC-3D to simulate ice features. The vertical distribution of ices Spatially mapping disk ice features is possible with JWST IFUs. Initial chemical abundances and evolution CO2 ice shows variation with time. CH3OH ice discriminates between “inheritance” and “reset” chemistry. Acknowledgements We gratefully acknowledge support from NSF award AST #2205698 and from the Virginia Initiative for Cosmic Origins. Scan to read the full paper Ice features vs. disk inclination H2O seen at 75-90o. CO2 and CH3OH are more prominent at higher inclinations. Scattered light features Ices features are present in the outer disk.


A putative condensin loading factor that controls yeast chromosome III architecture Abstract Manikarna Dinda1, Ryan D. Fine1, Mingguang Li1,2, and Jeffrey S. Smith1 1Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908. 2Department of Laboratory Medicine, Jilin Medical University, 132013, China. Condensin plays an important and evolutionarily conserved role in mitotic chromosome condensation, three-dimensional genome organization and regulation of gene expression. Condensin is a multi-subunit complex that has natural affinity for the promoters of highly transcribed genes, and also associates with specific transcription factors. However, a general mechanism for functional loading of the complex onto chromatin remains elusive. Our lab previously demonstrated that in haploid MATa yeast cells, condensin and Sir2 (a histone deacetylase) both associate with the recombination enhancer (RE), a cis-acting element on chromosome III that directs donor preference of mating-type switching. Here, Sir2 locally regulates transcription of a small gene called RDT1, while condensin contributes to the 3-dimensional organization of chromosome III, as well as donor preference, indicating that the RDT1 promoter region acts as a locus control region (Li et al., 2019). We have now further characterized the mechanism of condensin recruitment to the RDT1 promoter LCR, and uncovered a critical role for a non-meiotic version of the monopolin complex, known as cohibin (Lrs4 and Csm1 subunits), analogous to its known role in recruiting condensin to the rDNA locus. To test if cohibin functions more generally in condensin loading, or as a condensin accessory factor, we have performed ChIP-seq for genome-wide condensin binding sites in WT and lrs4∆ strains. Numerous Brn1 peaks (including RDT1 and the rDNA) were eliminated or significantly reduced by lrs4∆, consistent with the condensin loader hypothesis. Micro-C XL was then used to characterize the general effects of defective condensin recruitment on genomic conformation in a lrs4∆mutant, or when the Brn1 condensin subunit was depleted using an auxin-inducible degron system. Alterations were observed on multiple chromosomes, though the most severe changes occurred on chromosome III, which had significant negative effects on the efficiency of mating-type switching, as well as donor preference. We therefore hypothesize that cohibin (Lrs4/Csm1) is indeed a condensin loader at the RDT1 promoter region, where it establishes chromosome III conformation, potentially through a loop extrusion mechanism. Evidence for direct recruitment of condensin by the cohibin complex at other genomic sites and any possible role for cohibin in chromosome condensation are currently under investigation. Dr. Chongzhi Zang, University of Virginia Dr. Zhenjia Wang, University of Virginia Supported by NIH GM075240 and GM127394 Aim Establish whether Lrs4 is a condensin loader at RDT1 promoter region RDT1 promoter region HIS4 promoter region 6. lrs4 Δ reduces condensin binding at the RDT1 promoter region Condensin Sir2 RDT1 Mcm1 minimum 700bp RE Mcm1 ARS304 100bp HML HMR MAT RDT1 promoter region CEN Condensin 11. Hypothetical loop extrusion model after binding of condensin to the RDT1 promoter • Lrs4 is the condensin loader at RDT1 promoter region. • Condensin is recruited to the RDT1 promoter and regulates mating type switching by maintaining the chromosome conformation. • Presumably, condensin by loop extrusion is facilitating the interaction of HML with MAT to repair DNA breaks in MAT a cells. 12. Conclusion 5. Proposed model of condensin and Sir2 recuitment to the RDT1 promoter by Lrs4 and Mcm1 1. Mechanism of mating type switching in budding yeast 10. Condensin depletion leads to loss of interaction between MATa-HMLα, HMLα- HMRa in ChrIII during mating type switching 7. Lrs4 helps to recruit condensin at RDT1 promoter in MATa cells MAT a cells MAT ! cells 4. A putative


Why investigating social and geographic factors ? In France and the Netherlands, which might have been less affected by urban shrinkage, or in a less spectacular way, than the American Rust Belt or eastern Germany for example, urban shrinkage has been an emergent theme from the end of the 2000s (Wolff, 2017). Monitoring social and geographic conditions of growth and decline in cities Solène Le Borgne (M.A.), University of Amsterdam s.f.leborgne@uva.nl Research design • Mixed-methods approach: quantitative analysis (survey?), qualitative analysis (interviews) • Comparative approach: France & the Netherlands • Possible case studies: Nevers in France (34 000 inhabitants), and Terneuzen, Winschoten, Den Helder, Delfzijl, or the Achterhoek region (Gelderland) in the Netherlands Conceptual problems and methodology questions • Focus: are we looking at the social drivers, or the social impact of shrinkage, or both? • How to integrate a quantitative analysis to the qualitative approach, in order to answer the main research question? Comments? Suggestions? Write it down! Photos: Left: Nevers, location (Google Earth, screenshot) Right: Nevers (credits: Daniel Villafruela) Urban shrinkage in medium sized cities The decline of former industrial regions, and especially important cities, has been well documented. Less is known about the processes encountered by medium sized cities, sometimes located in rural regions. Yet, in France and the Netherlands, these are particularly affected by shrinkage (Guéraut, 2018). It is thus relevant to deepen our understanding of how shrinkage occurs, with which logics and outcomes, in this kind of space. The social dimension of shrinkage The topic has been tackled mainly by economic geographers and planners, with a focus on demography, policy making and governance. The social dimension of shrinkage – social drivers and social impact of the phenomenon – has been less analysed. Yet, this phenomenon does affect the social structure as a whole and the residents at the individual level. The social dimension, both as a factor and an outcome, needs to be better considered and analysed. How do the residents’ sociospatial ties influence their migration patterns in and out of shrinking cities? 1. What is the impact of life course events on the residents’ mobility? 2. How can one’s social ties be an incentive to stay or to leave? 3. How do place attachment and sense of belonging influence the residents’ migrations ? 4. What is the role of social and localized capital in the stay or leave decision? 5. Why coming back to the hometown after a period of outmigration? 6. What is the role of social capital in the successful installation of newcomers ?


CMS Experiment At the CMS experiment, a hierarchical set of algorithms, called the trigger system, processes and filters the incoming data stream. The CMS trigger system is structured in two stages: - Level 1 Trigger (L1 Trigger) implemented on custom-designed electronics, reduces the 40 MHz input to a 100 kHz rate. L1 Trigger algorithms are implemented on Field Programmable Gate Arrays (FPGAs) and have 3.2 μs to decide whether to pass an event to the next step. - High-Level Trigger (HLT) is a collision reconstruction software running on a computing farm. It scales the 100 kHz stream from the L1 Trigger rate to 1 kHz in 100 ms. The trigger system throws away 99.9975% of events (99.75% at the L1 Trigger). The Large Hadron Collider (LHC) at CERN operates at a rate of 40M events per second. This enables physicists to search for rare and new interactions. Due to technological limitations (e.g. storage constraints and readout electronics), the experiments at the LHC are required to reduce the amount of recorded data. The Princeton group at CMS is developing CICADA (Calorimeter Image Convolutional Anomaly Detection Algorithm). - CICADA is a fully autonomous AI algorithm that can process LHC event data in real-time - CICADA independently picks out topologies that are different from the majority of currently recorded events. - CICADA operates close to the rawest recorded data, i.e. calorimeter energy deposits. In this manner, CICADA has as little human bias as possible. CICADA leverages deep learning-based anomaly detection and methods for efficient neural network deployment in hardware. Anomaly Detection with Machine Learning Neutrino Experiments Elements: RAD Discoveries for Fundamental Physics Collaborators: Georgia Karagiori, Akshay Malige (Columbia University), Isabel Ojalvo, Pallabi Das, Adrian Pol (Princeton University) Anomaly detection is challenging when dealing with non-linear data relationships, especially in particle detectors. Deep learning, particularly Convolutional Neural Networks, excels at learning from raw energy deposits in this context by uncovering hierarchical features. This eliminates manual feature engineering and adapts to various input natures, making it ideal for image- based anomaly detection in calorimeter data, where calorimeter cells are treated as pixels representing energy deposits after projecting and unwrapping. The groups propose to utilize methods for efficient model deployment to meet computing constraints, i.e. quantization, pruning and knowledge distillation. - Quantization involves assigning the model’s weights and activations to a lower bit-width representation. - Pruning deals with the problem of the optimal removal of parameters deemed unimportant via some heuristic. - Knowledge distillation is a method of training a smaller network, called a student using soft labels generated by a larger network, called a teacher. Motivated by the use case, the Columbia and Princeton groups will propose novel methods for compression and deployment that are directly transferable to a broader physics community. Machine Learning on Highly Constrained Systems Student-Teacher Knowledge Distillation The teacher network condenses data into a latent space and then reconstructs back into the detector space using two NN. It then calculates the Mean Square Error Loss (MSE) between the output and input The student network uses a single dense layer Neural Network to calculate the MSE directly. Overall Project Goals: Advance detector real-time monitoring: Initially, we will instantiate AI algorithms to ``re-discover'' known physics processes or known detector issues, e.g. known dead channels, or noisy channels in the detector. The goal will be to demonstrate unsupervised learning capability in flagging detector abnormalities within the data. As part of this effort, we will also focus on physics/label-informed data dimensionality reduction. Goal 1. Goal 2. Goal 3. Expand physics capability of near-future experiments: N


A psychological approach to evidence‐based architectural design in domes7c spaces Colin Ellard1, Deltcho Valtchanov1, Thomas Seebohm1, Jus;n Perdue2, Sarah Susanka3 1University of Waterloo, Waterloo, Ontario Canada, 2Stantec Architecture, Toronto, 3Susanka Studios, Raleigh, NC Introduc7on In this experiment, we demonstrate a principled method for assessing the comfort, usability, and aﬀec;ve proper;es of a series of domes;c spaces. We combine high‐level visualiza;on with immersive virtual reality, mo;on tracking and structured interviews to assess the quali;es of a variety of styles of domes;c spaces. This ini;al study is meant as a “proof of concept” for future studies in a variety of built seTngs ranging from ins;tu;onal and health care environments to the urban scale. Method 3d visualiza;ons of three exis;ng domes;c structures were constructed using 3d Studio Max and V‐ray. The structures were Frank Lloyd Wright’s Jacobs House, Sarah Susanka’s Milstein House, and a typical North American suburban house. Par;cipants were provided with immersive experiences of the models using head‐mounted displays, infrared mo;on tracking, and mobile compu;ng. The models were realized at actual size in a gymnasium. Par;cipants explored the spaces un;l they felt familiar with them, and then they were asked a series of ques;ons about their preferences for par;cular loca;ons. Figure 1. A screenshot of the Milstein House visualiza7on Results Par;cipants were asked about their overall preferences for certain aspects of each of the models. Results suggested that designers’ inten;ons were, to some extent, manifest in the opinions of par;cipants. For example, the Milstein House, which was designed to enhance both opportuni;es for socializing and privacy [1], appears to have met both of these objec;ves. Table 1. Mean responses of par7cipants to general ques7ons pertaining to aﬀec7ve proper7es of the three VR models. Par7cipants were asked to rank each of the three models on a scale of 1‐5 for the parameters listed in the table. The ﬁnal ques7on asked par7cipants how likely they would be to purchase each of the homes if they had the opportunity to do so. Using Ajanachara so]ware [2] the spa;al proper;es of the home designs were analyzed to determine such proper;es as isovist size (area of space observable from a given loca;on), and other higher order proper;es of spa;al shape. Analyses were converted to contour plots to visualize how spa;al proper;es varied between loca;ons in the space. The ﬁgure below shows an example of such a contour plot from the Jacobs House. Figure 2. Spa7al analysis of Jacobs House. Colour coding corresponds to size of visible region of space from each loca7on in the space. Light colours indicate large visible regions of space and dark colours indicate small visible regions of space. Figure 3. Par7cipants were asked: “If this were your house and you were having a party, where would you go to oversee Conclusions The ﬁndings described here, although very preliminary in nature suggest the viability of a method for assessing the aﬀec;ve proper;es of architectural spaces using a combina;on of immersive virtual reality, mo;on tracking, and tradi;onal structured interview methods of experimental psychology. In future work, we hope to add to these ﬁndings by including measurements of physiological reac;ons during explora;on of such spaces, including eye movements, heart rate, skin conductance and EEG. References [1] Susanka, S. (1998). The not so big house: A blueprint for the way we really live. Taunton Press: Newton CT. [2] Wiener, J.M., Franz, G., Rossmanith N., Reichelt A., Mallot H.A., & Bulthoﬀ H.H. (2007). Isovist analysis captures proper;es of space relevant for locomo;on and experience. Percep:on, 36(7), 1066‐1083. This work was supported by funding from the Social Sciences and Humani:es Research Council of Canada. The authors gratefully acknowledge the assistance of Gloria Sicuro. Ela Malkovsky, Hannah Masterman, Leanne Quig


Sentinel-3 SLSTR Cal/Val activities for sea surface temperature measurements I. Tomažić (1), A. O’Carroll(1), G. Corlett (2), J.F. Piolle(3), P. Dash(4) , C. Donlon(5), D. Smith(6), S. Dransfeld(7), T. Hewison(1), A. Burini(1), F. Montagner (1) , V. Santacesaria(1) (1)EUMETSAT, Darmstadt, Germany (2)The University of Leicester, Leicester, United Kingdom (3)IFREMER, Plouzane, France (4)NOAA affiliate, US (5)ESA/ESTEC, Noordwijk, The Netherlands (6)RAL Space, Rutherford Appleton Laboratory, Harwell Oxford, UK (7)ESA/ESRIN, Frascati, Italy Introduction Copernicus Sentinel-3 (S-3) satellite carries the Sea and Land Surface Temperature Radiometer (SLSTR) and is a follow on of AATSR instrument. It is employing along track dual view scanning and two on-board calibration targets to obtain improved Sea Surface Temperature (SST) measurement. The first satellite in the series (S-3A) was successfully launched in February 2016 and the next one (S-3B) was launched in April 2018 to complete the first operational Sentinel-3 mission constellation. The next S-3 mission constellation (consisting from S-3C and S-3D) will ensure SLSTR data continuation for Copernicus program at least up to 2030. Sentinel-3A: 16th Feb 2016 Sentinel-3B: 25th Apr 2018 Instrument monitoring Geolocation verification Radiometric intercomparison: SLSTR vs IASI SST is the main parameter obtained from SLSTR instrument and one of the key parameters in global climate monitoring. Therefore, there is a very stringent requirement on producing SST retrievals from SLSTR. Absolute accuracy should be better than 0.3 K and with a temporal stability of 0.1 K/decade. To enable and confirm such a stringent requirements, set of Cal/Val activities are implemented for Sentinel-3/SLSTR mission both on Level-1 and Level-2 products. The main one on Level-1 encompasses monitoring of geolocation accuracy and radiometric inter-comparisons of SLSTR infrared channels with Infrared Atmospheric Sounding Interferometer (IASI), while on Level-2 it covers SST bias characterisation by comparison with in situ measurements and inter-satellite and inter-algorithm comparisons against Level-4 SST analysis. SST Bias Characterisation: Inter-satellite and inter-algorithm comparisons • Satellite comparison with OSI-SAF and CMEMS products • Analysing individual algorithms and instrument characteristics • Global and regional routine analysis • Daily, monthly plots, maps, time-series, histograms, .... • METIS: http://metis.eumetsat.int/sst/ SST Bias Characterisation: Comparisons with in-situ measurements • Copernicus Coriolis in situ service: drifters on GTS, OceanSITES (Pirata, GTMBA, ...) , Argo GDAC, GTSPP • Routine and automatic collocations (felyx) of SLSTR L1/L2 over in situ measurements and ship mounted radiometers • OSI-SAF Federated Activity SLSTR MDB: drifters, Argos, moored, radiometers •Current status: NRT@OPE and NTC@REPRO with SL L1 IR channels •Upcoming changes: NTC@OPE and NTC@REPRO with SL L1 all channels •Results presented for cycle 30: 07.04.2018-04.05.2018 •Results based on newly implemented Bayesian cloudmask SST L3 analysis Acknowledgements We would like to acknowledge The European Commission Copernicus Programme; The European Space Agency; Scientists and Industry throughout Europe. Special thanks to EUMETSAT, ESA and MPC/ESL collegues and to EUMETSAT S3-OPIT team. References EUMETSAT Sentinel-3 Mission Performance Implementation Plan (EMPIP), 2016, Issue v1C, pp.100 Sentinel-3 Calibration and Validation Plan, 2014, Eumetsat/ESA, S3-PL-ESA-SY-0265, Issue 2, pp. 235. Donlon, et al, The Global Monitoring for Environment and Security (GMES) Sentinel-3 mission, RSE, 120 (2012) Radiometric intercomparisons of AATSR and IASI, 2013, C. Whyte, D. Moore, J. Remedios Detector temperatures for IR channels from Jan 2017 to May 2018. Small discontinuities occur due to the scheduled decontamination or following an anomaly. The vertical lines indicate the start and end of each decontamination cycle. • Geolo


Surviving Involuntary Displacement: Homeowners vs. Renters Michael Moreno, University of Illinois at Chicago Dr. Joseph K. Hoereth, Institute for Policy and Civic Engagement, University of Illinois at Chicago Introduction Findings Recommendations Methodology Purpose Conclusions • In the late 1950s there was an increase in Hispanic presence within the community of Chicago. The city accounts for about 803,476 Hispanics who reside within the city alone (2016 American Community survey). • There is an ongoing trend of residential displacement within Hispanic dominated communities, in part due to urban revitalization initiatives that ignore minorities who live in the neighborhood. • Gentrification contributes to the displacement of inhabitants in major Hispanic dominated Chicago communities such as the Lower West Side (Pilsen), South Lawndale (Little Village), Humboldt Park, and Brighton Park. • Hispanic population in Chicago is high, but the number of Hispanics who own homes remain low in the neighborhoods mentioned; most of these inhabitants are renters. • As a result of Pilsen’s gentrification process, its Latino population has fallen from 89% in 2000 to roughly 82% in 2010, while the White population has increased by about 28% (Anderson 2012). Little village & Humboldt Park have shown similar cases. • Homeownership cannot guarantee that a Hispanic household owner would not be displaced, but it can certainly be an effective buffer in slowing the progression of any potential displacement. • The Correlation between homeownership rates and the displacement occurrences are further explored. • Gentrification does not have to mean displacement—If circumstances are aligned correctly. • In low-income neighborhoods where a significant percentage of residents own their homes, gentrification can be a life changing event for some families; leading to wealth-building that can dramatically improve their economic mobility. • Hispanic home buyers are more than twice as likely (42.8%) to have an FHA loan than a conventional financing loan—meaning Hispanics have to pay more in insurance premiums. • At 66.3%, Hispanics have a higher labor force participation rate than non-Hispanic Whites (60.8%) or the U.S. overall average (60.9%). • In 2018, Hispanics achieved a net gain of 362,000 homeowners. This raised the Hispanic Homeownership rate from 46.2% in 2017 to 47.1% in 2018. Over the past decade, Hispanics have accounted for 62.7% of net U.S. homeownership gains. • Change the narrative around immigration by underscoring the economic case for immigration reform and support policies that strengthen economic stability for Latino families. • Increase and mandate the amount of inclusionary zoning areas which require that 10% of new or renovated residential apartment buildings be maintained as affordable housing. • Provide renters with the opportunity & financing to purchase their units; Preserve & expand public housing. • Establish a loan fund to help small business owners buy their buildings. • Establish community benefit agreements with investors in large projects to ensure that local residents benefit from the investments. The research on the effects of gentrification in Chicago neighborhoods has been driven by scholarly articles, Lower West Side (Pilsen) studies, South Lawndale (Little Village) studies, and Humboldt Park studies in order to fully analyze such discourse and propose possible policy recommendations. Analyze the impacts of gentrification in Chicago Hispanic neighborhoods and encourages a closer look at the gentrification issue when creating community development and planning policies. References Anderson, M. B., & Sternberg, C. (2013). “Non-white” gentrification in Chicago’s Bronzeville and Pilsen: Racial economy and the intra urban contingency of urban redevelopment. Urban Affairs Review, 49(3), 435- 467.doi:10.1177/1078087412465590 Betancur, J. (2011). Gentrification and community fabric in Chicago. Urban Studies, 48 (2), 383-406. doi:


Democratising and making sense out of heterogeneous scholarly content SciLake aims to leverage and extend Science Knowledge Graph (SKG) technologies as the foundation to establish the concept of the Scientiﬁc Lake: an ecosystem for creating, combining, and querying cross-domain and domain-speciﬁc SKGs. SciLake_project https://scilake.eu Smart impact-driven discovery service for ● Multi-perspective citation analysis ● Impact propagation to related research objects ● Publication ﬁeld classiﬁcation ● Research trend identiﬁcation Scientiﬁc Lake as a service for ● Data acquisition ● Creation and interlinking of SKGs ● Data lake search and navigation Smart reproducibility assistant service for ● Research object recognition in textual data ● Research object link recommendation ● Text segmentation ● Citation-context assisted replication Research community pilots for service evaluation and showcase: ● Neuroscience ● Cancer ● Transportation ● Energy


−2 0 2 4 6 SNR Kp=196.5 km/s −2 0 2 4 6 SNR Kp=232.2 km/s −200−150−100−50 0 50 100 150 200 vrest [km/s] −50 0 50 100 150 200 250 300 350 Kp [km/s] −2 0 2 4 6 Signal-to-noise ratio                                                                                ~                                                                                ¡                   ¢                                                                                £                                                                                ¢       10−6 10−5 10−4 10−3 Volume Mixing Ratio 10−8 10−6 10−4 10−2 100 102 Pressure [bar] H2O 1800 K 2200 K 2600 K 3000 K 10−6 10−5 10−4 Volume Mixing Ratio OH 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Wavelength [micron] 1.05 1.10 1.15 1.20 1.25 1.30 1.35 Transit depth [%] T=2700 K


High-resolution observations in T Cha: the ATCA and ALMA view Transitional protoplanetary disks are considered as the "missing link" between disks surrounding young stars and planetary systems. These disks show little or no excess emission at λ < 10 μm and a signi?icant excess at λ ≥ 10 μm. This lack of near-infrared excess was interpreted as a diagnostic of inner disk clearing possibly connected to the early stages of planet formation (e.g., Calvet et al. 2002). Dust clearing can be related with gaps or holes within the disks, which can be created by several mechanisms, such as a close companion, disk photoevaporation, or giant planet formation. Until recently, no planet had been detected around stars with transitional disks, but this has changed with the recent ?irst direct detection of a young accreting planet around LkCa 15 (Kraus & Ireland, 2012; Sallum et al. 2015) and a yet uncon?irmed substellar companion inside the gap of the transitional disk that surrounds T Chamaleontis (T Cha, hereafter; Huelamo et al. 2011). This opens a very interesting research line for studying in-situ formation of planets in transitional disks, being a unique opportunity to capture a key moment of on-going planetary formation. I. de Gregorio-Monsalvo1, N.Huelamo2, M. Ireland3,4, C. Pinte5, E. Macias6, P. Tuthill3, H. Bouy2, S. Lacour7, A. Kraus8 (1) ESO-ALMA (Chile), (2) LAEX-Astrobiology Center (INTA-CSIC) (Spain), (3) Macquarie U. (Australia), (4) Australian Astronomical Observatory (Australia), (5) UMI-FCA, CNRS/INSU, France , (6) IAA-CSIC (Spain), (7) Observatoire de Paris (France), (8) Hawaii U. (USA) REFERENCES: Calvet et al. 2002, ApJ, 568, 1008 Cieza et al. 2011, ApJL, 471, L25 De Gregorio-Monsalvo et al. 2013, A&A, 557, 133 Dullemond & Dominik, 2005, A&A, 434, 971 Huelamo et al. 2011, A&A, 528, L7 Huelamo et al. 2015, A&A, 575, L5 Kraus & Ireland, 2012, ApJ, 742, L5 Sallum et al. 2015, Nature 527, 324 Motivation Fig 2. ATCA map at 7 mm. The spatial resolution is 0.2”x 0.2“ The case of T Chamaleontis: T Cha is a young (~7 Myr) nearby (108 pc) T Tauri star with a Spectral Energy Distribution (SED) typical of a transitional disk. Huelamo et al. (2011) reported the presence of a substellar companion candidate within its gap (T Cha b). T Cha is surrounded by an outer disk whose main properties have been inferred from the modeling of its spectral energy distribution (Cieza et al. 2011). Those models are highly degenerate and can ?it the SED equally well either with a very compact (few AUs) outer disk or much wider tenuous disk with a very steep surface density pro?ile. To shed light on the peculiar disk properties of T Cha, we performed high angular resolution observations in the submillimeter, millimeter, and in the centimeter regimes. Unveiling the outer disk properties using ALMA High spatial resolution and high sensitivity ALMA observations in continuum and in CO(3-2) at 850 μm show T Cha is surrounded by a compact dusty disk and a three times larger gaseous disk (see Fig 1). Using the CO(3−2) image we derive an outer radius of the gaseous disk of 230 AU, an inclination of 67±5 degrees and a position angle of PA=113±6 degrees. The gas emission is in Keplerian rotation, and the estimated dynamical mass of the central object is 1.5±0.2 Msun, in good agreement with previous estimations based on evolutionary tracks. The dusty disk is resolved at 850 μm and it shows a similar inclination and P.A. to the gaseous disk. The continuum intensity pro?ile displays two emission bumps separated by 40 AU, suggesting for the ?irst time the presence of an inner dust gap as predicted by SED modeling, and an outer radius of ~80 AU. These data allow us to rule out both the very small and large Rout families predicted by SED models (Huelamo et al. 2015). Comparison with radiative transfer models We used the radiative transfer code MCFOST with a tapered exponential edge in the surface density distribution for reproducing simultaneously the gas and the dust


Expression Patterns in the Developing Zebrafish of Two Paralogs of Activating Transcription Factor 5 (atf5a and atf5b) Roberto Rodríguez-Morales1, Viveca Vélez-Negrón1, Aranza Torrado-Tapias1, Gaurav Varshney2 and Martine Behra1 1. Department of Anatomy and Neurobiology, University of Puerto Rico, Medical Sciences Campus , San Juan, PR 2. Oklahoma Medical Research Foundation (OMRF), Oklahoma City, USA The Activating Transcription Factor 5 (ATF5) is a basic Zipper (bZIP) transcription factor (TF) with a proposed stress-protective, anti-apoptotic and oncogenic role. In Atf5 KO-mice, olfactory sensory neurons (OSNs) are immature and instable, and the olfactory bulb (OB) to where they project axons, is smaller. In the ventricular zone (VZ), a neurogenic brain region, Atf5 is strongly expressed and restricted to neuroprogenitors suggesting that it is necessary for their proliferation. However, a more systematic expression analysis found abundant Atf5 expression in various mature neuron populations and surviving Atf5-/- homozygotes are smell defective, but also less territorial and display several anxiety-like behaviors, suggesting additional roles in the CNS for Atf5. Furthermore, it is also expressed in other organs (liver, bones) in which it promotes differentiation of progenitor cells. Taken together, Atf5 function appears strongly context-dependent and additional work in physiological environments is needed. ATF5 is well conserved with two highly identical paralogs in Zebrafish: atf5a and atf5b. Here, we present the developmental expression patterns for both genes from 6-hour post fertilization (hpf) to 5-day post-fertilization (dpf), established by whole-mount in-situ hybridization (WISH) and semi-quantitative retro-transcription PCR (RT-PCR). We found ubiquitous maternal expression for both genes. From 2dpf onward, we found both genes expressed in the sensory epithelia of the inner ear. However, only atf5a was strongly expressed in the olfactory placodes and pits, with a weak and transient expression in the lateral line (LL). On the contrary, atf5b was not expressed in the nose and strongly expressed in the LL. Discrete bilateral regions in the midbrain and hindbrain were stained and partially overlapping at later developmental stages, with an earlier onset and broader staining for atf5a. Our work will facilitate future functional analyses in a genetic tractable animal model. Fig.2. Expression of atf5a and atf5b in the sensory lateral line (LL). (A, B, C) atf5a antisense mRNA probe hybridization in lateral view of whole-larvae at 2, 3 and 5dpf, with high- magnification (D,E,F) of NM corresponding to each developmental stage. (G,H,I) atf5b antisense RNA probe hybridization in lateral view of whole-larvae at 2, 3 and 5dpf, with high magnification (J,K,L) of NM to the left. SB: A,G= 200um, D,E=15um. Conclusions and Perspectives  atf5a/atf5b mRNAs are maternally contributed at 6hpf. atf5a is strongly expressed in olfactory organs, specifically in OSNs, while weakly expressed in LL. atf5b is strongly expressed in LL while not found in olfactory organs. Both genes are expressed in the developing brain, presumably neurogenic areas. Single and double-knock outs will shed light into the function of each in tissues described here. Fig.3. atf5a/atf5b expression in developing inner ear. (A,B,C) atf5a antisense RNA hybridization in the three cristae and maculae of the inner ear. (D,E,F) atf5b antisense RNA hybridization. SB: O,P=40um Fig.5. atf5a/atf5b expression in developing brain. (A,B,C) atf5a antisense RNA hybridization in dorsal view of undissected (A) and dissected (B,C) larval brains. (D,E,F) Same for atf5b. SB: A,B, = 150um. We performed whole-mount in-situ hybridization using antisense RNA probes for both paralogous genes (atf5a and atf5b). Their expression profile in zebrafish larvae, starting at 2dpf, is described below. Fig.4. atf5a expression in olfactory organ. (A,B,C) atf5a antisense RNA hybridization in dorsal view o


ATYPICAL ASPECT OF EWING SARCOMA A RARE CASE REPORT Authors: Paul-Mihai Boarescu, Dan Gheban, Ioana Chirilă 1 ¹ Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca Introduction Bone sarcoma is a rare disease, with an incidence of approximately 8 cases per million/year. It occurs in all ages but has a characteristic bimodal distribution, with peak incidences for adolescents and elderly. Ewing Sarcoma (EWS) is a mesenchymal-derived tumor that generally arises in bone and soft tissue. Intensive research regarding the pathogenesis of EWS has been insufficient to pinpoint the early events of Ewing sarcomagenesis. Results An 11 years old male child was admitted to Children Hospital Cluj for evaluation. At the physical examination a poorly delimitated tumor in the anterolateral muscle lodge of the shin was found. Tumor was adherent to the fibular periosteum. Biopsy was taken from the lesion. Case presentation At macroscopic examination the tumor of 6/3/2cm had yellow color and strong elastic consistency. Histopathological examination reveals a malignant structure of the tumor with small and blue cells infiltrating the muscle and periosteum. Tumor cells are arranged in islands separated by a well-represented conjunctive vascular tissue. In patches islands have a compact aspect but there are also islands with intercellular spaces giving it an alveolar aspect , cells have a syncytial aspect. Focal ischemic necrosis and capillary vascular permeation images are seen. Margins of the tumor piece are positives. PAS stain was focally positive. Immunohistochemistry showed an intense and diffuse positive reaction for CD99, while DES and SMA remained negative on tumor cells. Also ACL was negative, while S100 stain showed some focal stains to isolated tumor cells. Conclusion The histological aspect of the tumor using HE resembles with alveolar rhabdomyosarcoma but immunohistochemistry clearly proves that it is a neuroectodermal tumor type, like Ewing Sarcoma. For a better differential diagnosis between the two entities, Actin staining for nonspecific muscle staining and / or Myogenin would be required. Key words pediatric patient, Ewing sarcoma, alveolar rhabdomyosarcoma, immunohistochemistry References Harms D, Leuschner I, Krams M, Pilgrim TB, Treuner J.Rhabdomyosarcoma and extraosseous Ewing's sarcoma. Verh Dtsch Ges Pathol. 1998;82:83-98. Goldblum JR,Weiss SW, Folpe AL. Enzinger and Weiss's Soft Tissue Tumors, 6th Edition, ed. Elsevier, 2013 Fletcher CDM. Diagnostic Histopathology of Tumors, 4th Edition , ed. Elsevier , 2013


Water depth m -137 -900 failure affecting both post-glacial sediment drifts and older deposits: pressure ridges & slide blocks failure affecting only the flanks of post-glacial sediment drift deposits: thin skinned mudflows 5 km HE106 MKR18 MKR12 MKR13 MSC01-424 MSC01-301 fault P7 P4 P3 P8 affected deposits of the last sea-level fall and low stand erosive surface (ES1) Mud flow deposit (8,5 Cal. ky BP) affected post-glacial sediment drifts and drapes (unconsolidated muds) Twin Slides (Late Holocene) Northern Slide: remolding of slope deposits (pressure ridges) Southern Slide: affected oklder consolidated (and faulted) deposits of last s.l. fall generating a blocky slide Large Slide during last-glacial low stand (ca. 25ky BP) post glacial sediment drift and drapes Post Slide deposits Phase I Phase II Phase III Phase IV Sicily Gela Basin Italy 0 340 Kilometers SUBMARINE SLIDES Exposed Buried -800 -850 -200 -450 -400 -700 -750 -600 -300 -650 -350 -250 -550 -200 -250 -200 2 km 75 m SE NW profile HE 106 Northern Twin Slide Southern Twin Slide fluid-escape structures stacked mass-transport deposits basin-wide mass-transport deposit (Father Slide - last glacial) fluid-escape structures CHIRP sonar profile MKR12 S N Thick debrite accumulation Frontally-emergent MTD Frontal ramp Basal shear surface 1000 m 30 m Shallow-seated headwall Undisturbed seafloor S N CHIRP sonar proflile MKR13 Disturbed seafloor sector Buried MTD Potential “horse” Frontally-confined MTD 1000 m 30 m Distal sector with disrupted stratigraphy Central sector with folds and preserved stratigraphy Blocky area Debrites Buried MTDs CHIRP sonar profile MKR18 SE NW Shelf Deep-seated headwall Blocky area Debrites Elongated ridges Debrites Sidewall 1000 m 100 m TWIN SLIDES Where older and more consolidated units are mobilised, they result in more blocky slides, while younger and shallower units generated mudflow and plastic deformation of seafloor sediment resulting in distinctive pressure ridges in the toe region. REFERENCES MINISINI D., TRINCARDI F., ASIOLI A., CANU M., FOGLINI F. (2007) - Morphologic variability if exposed mass-transport deposits on the Eastern slope of Gela Basin (Sicily Channel). Basin Research, 19: pp. 217-240. MINISINI D. & TRINCARDI F. (2009) - Very high frequency failure of the continental slope: the Gela Basin (Sicily Channel). Journal of Geophysical Research, Vol. 114, F03014, doi:10.1029/2008JF001037. TRINCARDI F. & ARGNANI A. ( 1990) - Gela submarine slide: a major basin-wide event in the Plio-Quaternary foredeep of Sicily. Geo-Marine Letters, 10: pp. 13-21. TRINCARDI F., CATTANEO A., CORREGGIARI A., RIDENTE D. (2004) - Evidence of soft-sediment deformation, fluid escape, sediment failure and regional weak layers within the late-Quaternary mud deposits of the Adriatic Sea. Marine Geology, 213: pp. 91-119. VERDICCHIO G. & TRINCARDI F. (2008) - Mediterranean shelf-edge muddy contourites: example from Gela and South Adriatic Basins. Geo-Marine Letters, 28: pp. 137-151. DOI 10.1007/s00367-007-0096-9. FAILURE RECURRENCE Basin-wide correlation of Father Slide (generated on the onset of the Last Glacial Maximum) allows definition of at least six younger failure events (black dots) during the last 24 ky. This evidence implies a remarkable recurrence interval of ca. 4 ky (Minisini & Trincardi, 2009). Mass-transport deposits are up to 30 m thick and appear either shallowly buried or exposed at the seafloor. In both cases individual mass-transport deposits mobilize relatively small sediment volumes (typically in the order of 0.1-1 km3) and display modest run outs: - high-resolution multibeam data reveal several coalescing shallowly buried or exposed slides - CHIRP sonar profiles document recurrent failure events since the last glacial (about 20-25 ky BP). The margins of Gela basin, a 1000-m-deep slope basin in the Sicily Channel (Central Mediterranean), show evidence of widespread and recurrent sediment failure during the late Quaternary. Where exposed a


1.Background and Goal of the present work Paper materials are mainly of vegetative origin and contain cellulose and lignin as major structural constituents. Due to the deterioration by acid catalyzed hydrolysis, degradation of lignin, microbial and insect attacks, the material becomes brittle, frag- ile and discoloured and hence reinforcement is required in order to preserve the ar- chaeological and cultural value as well as the knowledge contained. Out of numerous techniques developed for paper conservation, gamma radiation in- duced graft copolymerization technique developed by the British Library in 1980s, possessed unique features of the possibility of internal grafting by the high penetra- tion power of gamma radiation, no remaining toxic residues and suitability to bulk and routine applications. Since resins and monomers with reactive unsaturated bonds, predominate in radiation curing techniques, acrylic monomers and unsaturated poly- ester/styrene mixtures widely utilized in conservation of organic materials. The present study is focused on the potential of utilizing inexpensive and readily available commercial alkyd resin for the reinforcement of naturally aged paper by gamma radiation induced graft copolymerization. 2. Experimental procedure 2.1. Analysis of the alkyd resin Commercial grade resin with undisclosed composition was utilized for the study and so it was analyzed for: Fatty acid composition Unsaponifiable matter content – ISO 6744-3 Material identification by GC-MS and FT-IR Physical properties (Viscosity, hardness, gloss & drying time) - in compliance with the standards used in the paint industry 2.2 Treatment of naturally aged paper The naturally aged paper samples were treated with chemical formulations containing mixtures with variable concentrations of alkyd resin and methyl methacrylate (MMA) and mixtures with variable concentrations of alkyd resin and styrene, followed by irra- diation. Gamma radiation dose of 15 kGy (at a dose rate of 0.33 kGy/hr) was utilized for the study, in order to achieve complete polymerization with minimum radiation damage to paper material. 2.3 Characterization of treated paper In order to determine the effectiveness of treatment, the samples were subjected to: Gravimetric measurement - to determine the polymer deposition yield Visual examination – to identify the alterations Scanning Electron Microscopy (SEM) Tensile strength - ISO 1924-2: 2008 Tearing resistance - ISO 1974: 2012 Water Absorbency - Total immersion method 3. Results and Discussion 3.1. Alkyd resin composition Oleic acid (C18:1) and Linoleic acid (C18:2) were identified as the major unsaturated fatty acids and they account for 49.2% and 7.5% of mass of extracted oil fraction of alkyd resin respectively. The resin contained 4.9% (w/w) of unsaponifiable matter. Number of aromatic compounds including phthalic anhydride, O-xylene, naphtha- lenes and ethyl and methyl benzenes were identified from the GC-MS. FT-IR peaks were in consistence with that of typical alkyd resin. 3.2 Physical properties of alkyd resin 3.3. Characterization of treated paper A positive correlation was observed between the polymer deposition yield and the res- in concentration, irrespective of the type of monomer. Testing Parameter Results Viscosity 240 s Hardness Passed Gloss 20° 25.3 60° 66.3 Drying time Surface (hrs) 2 Hard (hrs) 24 Alteration to the appearance of the treated paper samples was observed for higher al- kyd resin concentrations (30% and 40%) in both monomer solutions and hence Resin concentration of 20% was adopted for physical property evaluation. Comparison of SEM images of the control with the treated (20% of alkyd resin in MMA - Normal atmosphere) paper sample has been illustrated below and morphological changes indicate the sucess of graft copolymerization process. Comparison of SEM images of the control (top) with the treated (20% of alkyd resin in MMA) (bottom) Compared to the control, significant improveme


Ein Brief – zwei Perspektiven Stellenkommentare in digitalen Briefeditionen über APIs austauschen Ausgangssituation Ein Brief kann in mehreren Editionen publiziert und kommentiert vorliegen. In so einem Fall entstehen zum einen Kommentierungen, die in beiden Editionen ähnlich vorgenommen werden. Zum anderen werden aber auch Erläuterungen vorgenommen, die aus der spezifischen Perspek tive der Edition entstehen – d.h. mit Fokus auf diejenige Person, deren Korrespondenz ediert wird. Dadurch entstehen zwei Annotationslayer, die sich im Idealfall ergänzen. Die Einzelstellen kommentierung aus der jeweils anderen Edition kann also u.U. äußerst wertvoll für einen Nutzer sein. In digitalen Briefeditionen besteht nun prinzi piell die Möglichkeit, Daten aus anderen digi talen Editionen zu integrieren. Anstelle einer einmaligen manuellen Übernahme dieser Daten ist deren automatisierter Abruf über ein Appli cation Programming Interface (API) zu favori sieren. Daten aus externen Quellen können so schneller aggregiert, aktualisiert und zusammen mit den edierten Briefen angeboten werden. Im Regelfall liegen Einzelstellenkommentare in digitalen Briefeditionen heutzutage als Be standteil der TEI-XML-Dokumente vor (etwa im Element <note>). Sollen diese Kommenta re allerdings über eine Schnittstelle zur freien Nachnutzung durch externe Editionen angebo ten werden, müssen sie deutlich mehr Informati onen tragen, als das Element <note> im Kontext der Edition, z.B. Autor des Kommentars, Bezug stext etc. (siehe Codebeispiele rechts). Austauschformat Sinnvoll erscheint daher ein Datenformat, dass dediziert für den Austausch und die Aggregati on von Kommentaren, also vorwiegend textu ell vorliegender Annotation, konzipiert ist. Zwar wäre es möglich ein solches Format in TEI-XML neu zu definieren, allerdings gibt es für diesen Bereich bereits einen Standard, der auch schon breite Anwendung findet: das Web Annotation Data Model (WADM). Es wurde vom W3C entwickelt und im Februar 2017 offiziell als Recommendation aufgenom men. Gegenüber TEI-XML hat es den Vorteil, dass es alle notwendigen Angaben zu einem (Einzel stellen-)Kommentar kompakt vereint, wie die beiden Codebeispiele oben zeigen. Das WADM ist prinzipiell in mehreren Serialisierungen denk bar, allerdings wird JSON vom W3C empfohlen. correspSearch.net <TEI xmlns="http://www.tei-c.org/ns/1.0" xml:id="S00193"> 1 <teiHeader> 2 <fileDesc> 3 <titleStmt> 4 <title>Von Alexander von Humboldt. Hamburg, 28. Januar und 20. Februar 1791</title> 5 <editor> 6 <persName ref="http://d-nb.info/gnd/121069060"> 7 <forename>Franz</forename> <surname>Dumont</surname> 8 </persName> 9 </editor> 10 </titleStmt> 11 <publicationStmt> 12 [5 lines] <sourceDesc> 18 <msDesc rend="manuscript"> 19 <msIdentifier> 20 <institution>Freies Deutsches Hochstift / Frankfurter Goethe-Museum, 21 Frankfurt am Main</institution> 22 <repository>Autographensammlung</repository> 23 <idno> 24 <idno type="shelfmark">5051</idno> 25 <idno type="uri">http://kalliope-verbund.info/DE-611-HS-461600</idno> 26 </idno> 27 </msIdentifier> 28 </msDesc> 29 <pb n="1r"/> 55 <div type="writingSession" n="1"> 56 <opener> 57 <dateline rend="align(right)">Hamburg, den 28.ten Jan<ex>uar</ex> 1791.</dateline> 58 </opener> 59 <p> 60 <seg> 61 <orig>Fünf volle Monathe sind nun schon verflossen, seitdem ich die 62 <placeName key="S0022585">Rheinufer</placeName> verließ.</orig> 63 <note type="editorial">Im Juli 1790, nach der gemeinsam mit Forster den 64 Rhein hinab unternommenen Reise nach Belgien, Holland, England und 65 Paris, die vom 25.3. bis zum 11.7.1790 gedauert hatte.</note> 66 </seg> Wenn 67 Sie aus der Art, wie ich mich damals an Sie drängte, aus der frohen Stimmung, in 68 die mich jede Aeußerung Ihres Vertrauens und Ihrer liebevollen Zuneigung 69 versezte, auf Wärme und Herzlichkeit des Charakters in 70 mir schlossen, so muß es Ihnen jezt um so räthselhafter sein, daß Sie seit fünf 71 { 1 "@context": "http://www.w3.org/ns/anno.jsonld", 2 "type


Flex- Maßnahme Prakt. Potenzial Maschine Flex- Maßnahme Abruf Unternehmensplattform Marktplattform Intermediär Markt Flexnehmer n Marktplattform Praktisches PotenzialWerk Unternehmensplattform Demonstrator Abbildung: Daten- und Energiefluss Maschine Strommarkt Unternehmensplattform Marktplattform Unternehmens- plattform 1 Unternehmens- plattform n Maschinen Maschinen Unternehmen Von der Maschine zum Energiemarkt Die Rolle der Informations- und Kommunikationstechnologie Das Konzept der Energiesynchronisationsplattform Anwendung zum automatisierten Energieflexibilitätshandel Die Unternehmensplattform als Enabler Automatisierter Energieflexibilitätshandel > Daten- und Informationsflüsse > Entscheidung über Vermarktung/Inanspruchnahme von Flexibilitäten > Steuerung und Überwachung aller notwendigen Aktionen im Unternehmen Harmonisierung und Standardisierung von Schnittstellen > Flexibilität der Anlage wird über ein Kennzahlenset beschrieben > Alle Kennzahlen können sich im Betrieb laufend ändern >> Zustandsabhängigkeit der Flexibilität Dennis Bauer, dennis.bauer@ipa.fraunhofer.de Tel.:+49 711 970 - 1355 Marktplattform Unternehmensplattform Maschinen Unternehmen Marktplattform Unternehmensplattform Maschinen Maschinen Unternehmen 1 Unternehmen n Dienstleister Use Cases „proaktiv“ „reaktiv“ Einzellast aggregierte Lasten Einzellast aggregierte Lasten Eigene Entscheidung über Inanspruchnahme der Flexibilität Fremde Entscheidung über Inanspruchnahme der Flexibilität Energiesynchronisationsplattform 1. Bekanntgabe € bei P, t Wo / Wie kann die Flexibilität optimal genutzt werden? 2. Meldung des Lastgangs P, t 1. Bekanntgabe aktueller ∆P, t und € 2. Bekanntgabe t (Abruf) nationaler Markt (eex) regionaler Markt (otc) Energie- versorger Übertragungs- netzbetreiber Verteilnetz- betreiber regionale Ver- teilnetzbetreiber Regelleistung Börse Unternehmensplattform Marktplattform 1 2 Unternehmensplattform Manufacturing Service Bus (MSB) IaaS Schnittstelle Schnittstelle Marktplattform Service i Plattform Services Service j Iaas Provider Marktplatz für Services (Company Portal) Maschine / SPS 1 Maschine / SPS n Smarter Konnektor Angebot von Flexibilität Energieverbrauch Nachfrage nach Flexibilität Energieversorgung Energiesynchronisationsplattform Prozess- daten Steuer- signale Inserat Anfrage Produkt Abruf Fabrik m Prozess- industrie Fabrik 1 Prozess- industrie Maschine 1 Maschine 2 Maschine n Service Broker Registries Platform Services Domain Specifics System Data Space Service Data Space Service Layer Registrierte Services Energie- börse Last- optimierung Preis- prognose Wetterdienst … Aggregatoren Fabrik Maschine Entscheider Smarter Konnektor Wärmespeicher + Heizstab Zeit in min Leistung in kW Geldstrom in €/kWh Legende: P = Leistung ∆ P = Leistungsdifferenz t = Zeit € = Kosten Druckgussmaschine Elektrische Leistung Füllstand Zeit Unternehmen i i i Legende: MSB = Manufacturing Service Bus SPS = Speicherprogrammierbare Steuerung IaaS= Infrastructure as a Service Die Unternehmensplattform ist der Befähiger zum automatisierten Energieflexibilitätshandel mit Angeboten auf der Marktplattform. … nimmt Prozessdaten auf und ermöglicht eine Aggregation der Energieflexibilitätsmaßnahmen im Unternehmen. … unterstützt verschiedene Betriebskonzepte, um den individuellen Anforderungen der Unternehmen gerecht zu werden. 4 … ermöglicht ein Management der Maßnahmen sowie Services zur Optimierung des Einsatzes der Energieflexibilität. … bietet die einheitliche Schnittstelle zu verschiedenen Energiehandelsangeboten auf der Marktplattform. 3 Die Unternehmensplattform… 1 2 3 4 Das Konzept der Energiesynchronisationsplattform bildet eine branchenübergreifende Lösung zum Energieflexibilitätshandel. ... bietet ein durchgängiges Konzept für den automatisierten Energieflexibilitätshandel von der Maschine bis zum Energiemarkt. … identifiziert zusätzliche Services für die Aggregation, Verarbeitung und den Austausch von Daten. … gliedert sich in die beiden Teilplattformen


H-band de Boer et al. 2016 Searching for accreting protoplanets in transitional disks: SPHERE/ZIMPOL observations N. Huélamo (CAB, Spain), G. Chauvin, A. Lagarrigue, M. Benisty (U. Chile/IPAG), H.M. Schmidt, S. Quanz (ETH Zurich), E. Whelan (Maynooth Univ., Ireland), J. M. Alcalá (INAF, Italy), D. Barrado, B. Montesinos, I. Mendigutía (CAB, Spain) The project: When planets formed, they are surrounded by circumplanetary disks (CPDs). Different theories predict that magnetospheric accretion can occur from the CPD onto the planet. We aim at detecting accreting protoplanets within the gaps of transitional disks, using the Hα emission line as an accretion tracer. To achieve our goals, we have performed spectral angular differential imaging (ASDI) observations with SPHERE/ZIMPOL at the VLT. In this poster, we show our results for two transitional objects: the Herbig Ae star MWC758, and the T Tauri star RXJ1615.3-3255. RXJ1615.3-3255 RXJ1615.3−3255 0 100 200 300 400 distance to the star (mas) 12 10 8 6 4 2 0 Contrast−5σ (mag) CntHa NHa Diff Figure 3 – Left: SPHERE/IRDIS H-band image of RXJ1615 from de Boer et al. 2016, where several rings (R) and arcs (A), a gap (G), and an internal disk (I1) are detected. Right: SPHERE/ZIMPOL images of RXJ1615 in two individual filters (NHa & CntHa) and the difference image (NHa-CntHa). Figure 4: SPHERE/ZIMPOL 5σ contrast curves obtained in the two individual filters NHa and CntHa in ADI, and in the NHa- CntHa difference in ASDI. Preliminary curves obtained using Classical ADI. RXJ1615.3-3255: This T Tauri star (TTS) has been imaged by SPHERE/IRDIS in the near-IR (de Boer et al. 2016, Figure 3, left), and shows a disk with several structures: arcs, rings and a clear gap at 0.5 arcsec (79 au@158 pc). Our ZIMPOL ASDI dataset does not show any source within a 1” radius from the central star. Note that our preliminary analysis shows a contrast of 6 mag at 50 mas (8 au) in the ASDI image, and 8 mag at 200 mas (32 au) using classical ADI (cADI). (Huélamo et al., in prep.) SPHERE/ZIMPOL optical images Contrast curves Separation (mas/au*) Contrast NHa (mag) log LHα (L⦿) log Lacc (L⦿) log Macc (M⦿) 50 / 8 5.0 -5.0 -4.0 -8.4 100 / 16 7.6 -6.1 -5.3 -9.7 200 / 32 8.2 -6.3 -5.6 -10.0 Table 2: SPHERE/ZIMPOL Hα contrast, line and accretion luminosity at different separations from the star. We have also estimated the accretion rates (Macc) for a 1 MJup planet with 1 RJup radius. MWC758: This Herbig Ae star is surrounded by a disk with several spiral arms. Reggiani et al. (2017) reported the detection in the L’-band of a planet companion candidate at 111 mas (see Fig. 1, left). We do not detect it in the SPHERE/ZIMPOL images. Note that we reach a contrast of ~8 mag at 111 mas (see Fig. 2) in the ASDI image. MWC758 (Huélamo et al. 2018) Figure 1 – Left: L’-band image of MWC758 from Reggiani et al. 2017. The spiral arms in the disk (S1, S2 and S3), together with the protoplanet candidate (b), are marked. Right: SPHERE/ZIMPOL images of MWC758 in two individual filters centered in the Hα line (BHa) and the adjacent continuum (ContHa), and the differential image (BHa-ContHa). The red circle shows the position of the L’ source detected by Reggiani et al. 2017. L’-band SPHERE/ZIMPOL optical images Reggiani et al. 2017 0 100 200 300 400 12 10 8 6 4 2 0 0 100 200 300 400 distance to the star (mas) 12 10 8 6 4 2 0 Contrast 5σ (mag) 0 100 200 300 400 distance to the star (mas) 12 10 8 6 4 2 0 Contrast 5σ (mag) CntHα BHα BHα−CntHα Figure 2: SPHERE/ZIMPOL 5σ contrast curves obtained in CntHa, BHa in ADI, and in BHa-CntHa in ASDI. The grey area shows the separation of the companion candidate detected in L’. Contrast curves planet candidate separation * distance ～158 pc (GAIA DR2) NHa -400 -200 0 200 400 ∆ RA (mas) -400 -200 0 200 400 ∆ DEC (mas) CntHa -400 -200 0 200 400 ∆ RA (mas) -400 -200 0 200 400 NHa - CntHa -400 -200 0 200 400 ∆ RA (mas) -400 -200 0 200 400 Separation (mas/au*) Contrast BHa (mag) log LHα (L⦿) log Lacc (L⦿)


Low high Radiation Phylum Javier Edo Varg, Pablo Burraco, Sergey Gaschack & Germán Orizaola Genus Abundance % Abundance % medium Low high Radiation medium Bacteria Unclassiﬁed Bacteroidetes 16S Library DNA Extraction MiSeq illumina Seq Chlamydiae Cyanobacteria Firmicutes Proteobacteria Tenericutes Environmental pollution can inﬂict biological damage to organisms aﬀecting their life histories. Here, we use the Eastern treefrogs (Hyla orientalis) as study model , to examine the consequences that living ir areas contaminated by radioactive material from the Chernobyl accident, occurred in 1986, had on the diversity and composition of gut microbiome. We collected 80 individuals in ﬁve localities inside the Chernobyl Exclusion Zone during the spring 2017, one locality under high radiation levels (> 11 microSv/h), two on mid radiation (2-4 microSv/h) , and two on low radiation levels (< 0.11 microSv/h). The long-term exposure to ionizing radiation on Chernobyl can give us information about negative eﬀects of the radiation, as well as insights into putative adaptation patterns in these organisms. The duodenum of the frogs was preserved for DNA extraction in situ. The region between 515F and 806R of the 16S rRNA was targeted and ampliﬁed through PCR. Speciﬁc Illumina barcodes i5 and i7 were used to make the Illumina libraries. The resulted amplicons were sequenced on an Illumina Miseq at the Science for Life laboratory (Uppsala University, Sweden) to estimate total microbial diversity. The sequencing resulted in 1382 ﬁltered Operational Taxonomic Units (OUTs). The OTUs were clustered at 97% of identity and showed a high percentage of Proteobacteria, Firmicutes, and unassigned bacteria. The composition of the gut microbiome in Hyla orientalis diﬀered between radioactive contamination levels. Further studies are needed to fully understand the implications of these diﬀerences, as well as their possible eﬀects on organismal ﬁtness. Effects of long term exposure to ionizng radiation on Chernobyl treefrogs gut microbiome Bacteria Unclassiﬁed Phylum Cyanobacteria Family Clostridiaceae Clostridium_sensu_stricto_1 Tyzzerella_3 Anaerotruncus Verticia Ralstonia Family Enterobacteriaceae Methods Results Conclusions C o l l e c t i n g https://www.resear- chgate.net/proﬁle/- Javier_Varg https://twitter.- com/jedovarg https://orcid.org/0000-0002-7895-4563 https://www.linke- din.com/in/ja- vier-edo-varg-varg- a9509b60/ https://www.insta- gram.com/javiere- dovarg/ #VargPhD The genus Tyzzerella is found only in frogs with a high level of radiation The phylum Firmicutes and Proteobacteria are signiﬁcantly diﬀerent between radiation levels Project still in progress Acknowledgement 16 65.3 16.6 7.3 81.8 10.2 7.9 15.4 76.6 5.2 9.1 42.7 25.8 10.7 7.9 13.5 6.3 13.9 49.7 8.9 61.7 5.3 15.9


COUNTRY/REGION KEY WORDS sustainability, technological in- novations, practices, small and medium-sized industry, rural areas DISCLAIMER This Practice Abstract reflects only the author’s view and the Branches project is not responsible for any use that may be made of the information it contains. 43 Specialty heartwood timber from oversized Scots pine logs Natural Scots pine heartwood is a valuable resource because of extractives, which make it moisture and decay resistant. The older and larger the tree gets, the more heartwood it contains. Most of the sawmills are unable to saw oversized logs rich in heartwood and thus the fate of the valuable logs would be in energy production as wood chips. Since 1994 the family owned business Finnstamm Oy has been specialized to saw extra large knot-less butt logs of Scots pine. According to the Scandinavian standards those logs are oversized for other sawmills. The logs come from PeFC-certified sources and are sawn to high quality heartwood timber for the woodworking and furniture industry. Dimensionally stable solid heartwood material without any adhesive layers is especially suitable for window and door frames. For the sawing, the butt logs with high heartwood proportion are selected and then guided through metal detector. The butt end is reduced and debarked and got through an extra large horizontal saw and circular saw. The saw may be used to radial cutting, which makes the timber more weatherproof and increases the durability. A customer specifies the drying method, which can be performed in a three-chamber hot air drying kiln or in open- air. The dry timber is guided to cut-off line and planing, if needed. After packaking the product is ready to be dispatched to the customer. Use of durable wood in constructions increases the storage time of carbon and provides foundation for the recovery of wooden building materials. Now that the era of hazardous super-effective wood preservatives is over, more benign solutions are searched for to attain optimal durability. Durability related characteristics of Scots pine heartwood have been studied in Natural Resources Institute Finland (Luke). DOWNLOAD www.branchesproject.eu AUTHORS Heikki Rytkönen (Finnstamm) Anni Harju (Luke) Martti Venäläinen (Luke)


VISUALIZING DIGITAL COLLECTIONS User-Friendly Search and Browse Tools Digital Archive International History Declassified The Wilson Center Digital Archive contains declassified historical documents drawn from archives all over the world. Founded in 1991 to encourage access to newly opened archives in Eastern Europe, the first version of the Digital Archive was focused on historians and expert researchers. 50,000 pages of documents 100 different archives 24 different languages In 2013, the website was redesigned to make it more accessible for new users and students. Previously users could only “browse” through a list of thematic collections. The timeline updates to show the number of documents over time and a list of common subjects. Events like the Cuban Missile Crisis appear as spikes on the timeline. A simple visual interface provides users with a broad overview of our collections, giving them context to begin exploring. Users can use the interactive map to select a region, country or city of interest. stefaner.eu Open source facet browser which displays the proportion of items in each metadata category and allows users to visually filter results. viewshare.org Free platform developed by the Library of Congress to create new “views” for interacting with digital collections. neatline.org Add-on tools for Omeka that can create interactive exhibits by plotting objects, documents, and ideas against interlinked maps, timelines, and narrative text. Documents above: Soviet telegram with handwritten instructions from Stalin, 1947 (RGASPI); Draft of telegram by Mao Zedong, 1950 (PRCFMA) Free and Open Source Tools Laura Deal Catalog Specialist Woodrow Wilson International Center for Scholars Once users have identified a region, date, or subject of interest, they can view a list of results that can be further refined with the advanced search bar. Visual Browse New tools are becoming available every day which build on top of existing metadata and collection management systems. Data visualizations give users new ways of thinking about and exploring existing digital collections. Providing users with context to explore before they search Viewshare Elastic Lists Neatline


CROSS-SECTIONS FOR THE SOLAR NEUTRINOS CAPTURE AND CHARGE-EXCHANGE RESONANCES Grigory Koroteev MIPT Email: koroteev@phystech.edu Phone: +79252279046 Contact 1. Yu. V. Gaponov, Yu. S. Lyutostanskii, JETP Lett. 15, 120 (1972). 2. J. N. Bahcall, A. M. Serenelli, and S. Basu, Astrophys. J. Lett. 621, L85 (2005) 3. N. Borzov, S. A. Fayans, E. L. Trykov. Nucl. Phys. A 584, p. 335 (1995). 4. Yu. S. Lutostansky JETP Lett. 106, 7 (2017). 5. A.A. Borovoi, Yu.S. Lutostansky, I.V. Panov, et. al., Pis’ma Zh.Eksp.Teor.Fiz. 45 №11, 521-523 6. Krofcheck D., et al. Phys. Rev. Lett. 1985. V.55. P. 1051; 7. Yu.S. Lutostansky, N.B. Shulgina. Phys. Rev. Lett., 1991, v. 67 8. Yu. Lutostansky. Physics of Atomic Nuclei, 2011, Vol. 74, No. 8, pp. 1176–1188 9. M. Palarczyk, et. al., Phis. Rev. 59 10. J. Rapaport, P. Welch, J. Bahcall, et al. Phys. Rev. Lett. 54, 2325 (1985) References Investigation of charge-exchange resonances is important for calculating neutrino capturing cross- sections σ(E) of nuclei that can be used in neutrino detectors. Analog resonance, Gamow-Teller resonance (GTR) and three pigmy resonances are selected. Calculations were performed using the self-consistent theory of finite Fermi systems for Ga-71, Mo-98 and I-127. Even not accounting GTR gives a decrease of the σ(E) value more than 25%. Numbers of events in the interaction of solar neutrinos with these three nuclei calculated. It is shown that boron neutrinos make the main contribution and it is important to take into account all resonances. Abstract Nuclear Resonances Theory - The are 3 types of the charge-exchange allowed resonances: Gamow–Teller and the analog resonances, and pygmy resonances. - They can be good described using microscopic theory and in model approximation. - The calculated values of the energies of Gamow–Teller and analog resonances, are in good agreement with their experimental data. - Pygmy resonances may be described using the same approach as for Gamow–Teller and analog resonances. - The role of pygmy resonances is very important in the charge-exchange reactions and in neutrino capturing and beta-delayed process. Conclusions Neutral ( ΔQ = 0 ) and charge ( ΔQ = 1 ) excitation branches of nuclei. Gamow–Teller resonance (GTR), analog resonance (AR), and three pygmy resonances (PR1, PR2, PR3) are indicated for the A(N-1,Z+1) nucleus. [1]    Q E e e e A dE E Z F E S E p c g E      0 4 3 . 2 ) , ( ) ( ) (  M2GTR ≈ 3 (N-Z) eq2 M2IAS ≈(N-Z) where Vpn and Vpn h are the effective fields of quasi- particles and holes, respectively; Vpn ω is an external charge-exchange field; dpn 1 and dpn 2 are effective vertex functions that describe change of the pairing gap Δ in an external field; Γω and Γξ are the amplitudes of the effective nucleon–nucleon interaction in, the particle–hole and the particle–particle channel; ρ, ρh, φ1 and φ2 are the corresponding transition densities. [3] Local nucleon–nucleon δ-interaction Γω in the Landau-Migdal form used: Г= С0 (f0′ + g0′ σ1σ2) τ1τ2 δ(r1- r2) where coupling constants of: f0′=1.35 – isospin- isospin and g0′=1.22 – spin-isospin quasi-particle interaction with L = 0. [4] Constants f0′ and g0′ are the phenomenological parameters.          n p n p p n np, pn q pn Г V e V    The Gamow–Teller resonances and other charge- exchange excitations of nuclei are described in Migdal TFFS-theory by the system of equations for the effective field:         n p h n p p n np, h pn Г V           n p n p p n np, pn Г d 1 1           n p n p p n np, pn Г d 2 2   Matrix elements MGT : where χλν – mathematical deductions           2 1 2 1 2 1 2 1 2 V A M GT   G -T values are normalized in FFST:    i q i Z N e M ) ( 3 2 2 Effective quasiparticle charge is the “quenching” parameter of the theory. 0.1 8.0 2   qe Yury Lutostansky1, Alexey Osipenko1, Victor Tikhonov1, Almaz Fazliakhmetov2,3, Grigory Koroteev2, Andrey Vyborov2,3 1National Research center ”Kurchatov Institute”, Russi