Characterizing pathways of exposure for risk-based chemical prioritization Data streams Large public inventories, reporting chemical use and/or occurrence: • ACToR USEdb [3]: manually-curated pathways database (2015) • CompTox Chemicals Dashboard (CCD) chemical lists [4] (https://comptox.epa.gov/dashboard/chemical-lists) • Chemical Data Reporting 2016-2020 [5] • CPDat (Chemical & Products Database) [6-11] via ChemExpo (see poster P284/abstract 3795) • Chemical-Product Composition data • Functional Use categories • Chemical List Presence (curated tags) Data streams include 62,692 unique DSSTox Substance IDs Figure 2. Data streams for food-only chemicals. Left panels: Specific CCD lists. Upper/lower panels: Chemicals with multiple/single data streams. Many chemicals have info only from CCD lists of food volatiles or food contact substances. https://comptox.epa.gov /dashboard/chemical- lists Case Study: Food-Only Chemicals For references or copy of poster: Scan QR code or https://github.com/carolinering/pathwaysSOT2023 Contact: ring.caroline@epa.gov Caroline L. Ring1; Paul M. Kruse1,2; John F. Wambaugh1; Kristin K. Isaacs1 1 US EPA Center for Computational Toxicology and Exposure (Research Triangle Park, NC, USA) 2 Oak Ridge Institute for Science and Education (Oak Ridge, TN, USA) Pathway classifications Figure 1. Heatmap of pathway classifications (left panel) and data stream sources (right panel) for 62,692 unique DTXSIDs. Overview Manual mapping of chemical exposure data to broad exposure pathway categories to categorize 62,692 chemicals by exposure pathway Methods Scientific Impact & Potential Applications • Pathways can be used to inform rapid exposure models for use in risk-based chemical prioritization [1], e.g.: • as a training set for automated read-across of exposure pathways based on chemical structure • as features (predictor variables) for machine-learning models of exposure [2] Consumer o Fragrance o Personal care o Cosmetic Pesticide o active o inert Industrial Pharmaceutical Food/Dietary Other o Flame retardant o Tobacco o Colorant o Commercial o Agricultural  Fertilizer o Biocide  Herbicide  Antimicrobial Chemical may be positive, negative, or unclassified (no data, NA) for each pathway. Negative = ChemExpo Chemical List Presence tags "prohibited", "restricted", "not used", "non_food_use", "nondetect" Classifications from each data stream may disagree. Here: • Any positive = positive overall. • No positive & any negative = negative overall. • All NA = NA overall. 6583 chemicals positive for the Food pathway and negative or NA for all other pathways Case Study Summary • Transparent, granular sourcing for pathway categorization • Majority of food-only chemicals rely on data from 1-2 lists • Food-only chemical classes are consistent with source lists (e.g. flavors) Figure 3. ClassyFire classifications for food-only chemicals. Colored rings: # of food-only chemicals in each superclass (inner ring) and class (outer ring, labels). Most frequent classes: Prenol lipids; Fatty acyls; Organooxygen compounds. Visualized using ClassyFire [12] & treecompareR package (see poster P160/abstract 3675). Fatty acyls Prenol lipids Organooxygen cpds.


Understanding Lithium Extraction Through Social Life Cycle Assessment in the American Context: A Critical Review Megan Jermak, Sarah Cribb, Joseph Bozeman III, PhD CEM Georgia Institute of Technology | Social Equity and Environmental Engineering Lab Benoît, C. et al. (2021). Guidelines for Social Life Cycle Assessment of Products and Organizations 2020. Life Cycle Initiative. United Nations Environmental Programme. www.lifecycleinitiative.org/wp-content/uploads/2021/01/Guidelines-for-Social-Life-Cycle-Assessment-of-Products-and- Organizations-2020-22.1.21sml.pdf. Benoît, C. et al. (2009). The Guidelines for Social Life Cycle Assessment of products: Just in time! The International Journal of Life Cycle Assessment, vol. 15, no. 2, 21 Jan. 2010, pp. 156–16., https://doi.org/10.1007/s11367-009-0147-8. Riofrancos, T. (2022). The Security–Sustainability Nexus: Lithium Onshoring in the Global North. Global Environmental Politics, 23(1), 1–22. https://doi.org/10.1162/glep_a_00668 Jaskula, B. W. (2024). Lithium. In U.S. Geological Survey mineral commodity summaries 2024. U.S. Geological Survey. https://pubs.usgs.gov/periodicals/mcs2024/mcs2024-lithium.pdf Mancini, L., & Sala, S. (2018). Social impact assessment in the mining sector: Review and comparison of indicators frameworks. Resources Policy, 57(57), 98–111. ScienceDirect. https://doi.org/10.1016/j.resourpol.2018.02.002 Chhipi-Shrestha, G. K., Hewage, K., & Sadiq, R. (2014). “Socializing” sustainability: a critical review on current development status of social life cycle impact assessment method. Clean Technologies and Environmental Policy, 17(3), 579–596. https://doi.org/10.1007/s10098-014-0841-5 Grubert, E. (2016). Rigor in social life cycle assessment: improving the scientific grounding of SLCA. The International Journal of Life Cycle Assessment, 23(3), 481– 491. https://doi.org/10.1007/s11367-016-1117-6 Ramirez, P. K. S., Petti, L., Haberland, N. T., & Ugaya, C. M. L. (2014). Subcategory assessment method for social life cycle assessment. Part 1: methodological framework. The International Journal of Life Cycle Assessment, 19(8), 1515–1523. https://doi.org/10.1007/s11367-014-0761-y Bozeman, J. et al. (2022). A path toward systemic equity in life cycle assessment and decision-making: Standardizing sociodemographic data practices. Environmental Engineering Science, vol. 39, no. 9, 1 pp. 759–769. https://doi.org/10.1089/ees.2021.0375. Social Life Cycle Application Conclusion and Recommendations Acknowledgements In this critical review, lithium mining is examined under the context of its extraction phase, examining how social and environmental outcomes in foreign mining projects may be echoed in new American mining endeavors. Industrial ecology tools, such as Social Life Cycle Assessments (SLCAs), can be utilized to draw comparisons of unit operations across varying countries and contexts. As part of the guidelines established by the United Nations Environmental Programme (UNEP) for implementing SLCAs, two Life Cycle Inventories (LCI) were conducted analyzing the social impacts of lithium mining operations. One LCI addressed lithium mines currently operating within South America (SA), while the other LCI investigated data on a Thacker Pass, a proposed mine within the United States (US). Social Life Cycle Assessment (SLCA) is a tool developed by the United Nations Environment Programme/Society for Environmental Toxicology and Chemistry (UNEP/SETAC) for the analysis of social impacts associated with a product’s life cycle from cradle to grave (UNEP, 2009). Although SLCA has evolved significantly in recent years, limited standardization of procedures has restricted its use in the US. Meanwhile, the U.S. is rapidly expanding its lithium mining industry to meet electric vehicle (EV) demand and stabilize lithium supply chains (Riofrancos, 2022). While US mining companies posit American mines as safer and more sustainable than those in the global South, storied negative social implicati


Capabilities, contents, and use cases of the Outer Planets Unified Search (OPUS) from the PDS RMS Node Megan R.K. Seritan, M.S. Tiscareno, R.S. French, M.R. Showalter, M.K. Gordon, Y.-J. Chang, D.J. Stopp, J.N. Spitale, M.J.T. Mace, E.R. Simpson | SETI Institute—Mountain View, CA The Planetary Data System (PDS) is NASA’s scientifically-guided archive for planetary science: The Ring-Moon Systems (RMS) Node is a PDS Discipline Node located at the SETI Institute in Mountain View, CA: The Outer Planets Unified Search (OPUS) is a cross- mission, cross-instrument data search tool: What is PDS? What is RMS? What is OPUS? OPUS Support of Cross-Discipline, Cross-Instrument Search What’s New! • Users can now search using detailed geometric metadata for all Galileo SSI images Example 2 of RMS-generated metadata: Geometric metadata Galileo SSI metadata Cassini UVIS HDAC Cassini UVIS HSP Cassini UVIS EUV Cassini CIRS Cassini CIRS Cassini ISS Different Filters Cassini VIMS New Horizons MVIC OPUS provides rich, consistent metadata • OPUS now includes New Horizons LORRI and MVIC data through the end of 2020 New Horizons new data • New previews and diagrams are available for browsing and downloading • These provide at-a-glance identification info for these non-image observations • Four different Voyager instruments are supported: PPS, UVS, and RSS (occultation) & ISS (reflectance) Previews show the occultation profile itself… …while diagrams show the source’s path through the field of view. • OPUS now supports PDS4 datasets! • Metadata still consistent and accurate! Related concepts with different names, such as “volume” (PDS3) and “bundle” (PDS4), are combined • Earth-based Uranus ring & atmosphere stellar occultations from 1977-2002 is the first PDS4-only data set in OPUS Support for PDS4 OPUS geometric search categories 0.5 0.6 0.7 0.8 Hubble WCF3 F689M Galileo SSI Red Voyager ISS Orange Cassini ISS Red 0.65-0.72 μm 0.62-0.73 μm 0.59-0.64 μm 0.57-0.72 μm wavelength (μm) Example 1 of RMS-generated metadata: Consistent wavelength information Example 3 of RMS-generated metadata: Information-rich search results • Archival datasets, especially in PDS3, were not designed with cross-discipline, cross- instrument search as a goal • Because of this, the metadata in these archival datasets that would make cross- discipline, cross-instrument search possible is usually incomplete or missing, at no fault of the data provider • The major benefit of OPUS is that RMS creates consistent supplemental metadata fields to facilitate cross-mission, cross-discipline search • See the following examples of RMS-generated metadata that allow cross-discipline, cross- instrument search: • OPUS makes wavelength into a standardized attribute • This feature addresses the issue of filters covering similar, but not identical, wavelength ranges and having various names • For example: • When wavelength is a standardized attribute, users can find related observations that may not have been found when looking at archived metadata alone • OPUS geometric metadata identifies every body and ring inside the field of view of an image • This metadata is derived by densely sampling the field of view and reporting the full range of values for each geometric parameter • These attributes are available in a consistent way for every supported dataset • RMS-generated thumbnails are a visual type of metadata to make cross-discipline, cross- instrument search easier • Some sets of thumbnails use color-coding to indicate wavelength/filter type: • A federated structure of six discipline-specific nodes and two support nodes • Run by scientists who bridge the data community and the research community • Provides expert curation and peer review of datasets • The Node’s emphasis is on datasets in which rings, moons, and/or their primary bodies are viewed as a system • We focus on placing individual data products in context • In practice, this works out to: o Jupiter, Saturn, Uranus, Neptune, Pluto, &


Management and Uncertainties of Severe Accidents L.E. Herranz (CIEMAT), S. Paci (UNIPI) MUSA was founded in HORIZON 2020 EURATOM NFRP-2018 call on “Safety assessments to improve Accident Management strategies for Generation II and III reactors” On June 15th, 2018 MUSA obtains the NUGENIA label that recognizes the excellence of the project Numerical tools are widely used to assess the Nuclear Power Plants (NPP) behaviour during postulated Severe Accidents (SA). Considering the complexity of the processes taking place during a SA and the inherent nature of numerical codes (numerics, spatial discretization, etc.), it is mandatory to quantify their embedded uncertainties taking into account the latest developments in methods and algorithms as well as the availability of computing resources. Mathematical tools for quantification of code uncertainties and sensitivities have been under development for many years, with a huge accumulated experience in performing Uncertainty Quantifications (UQ) with Best Estimate (BE) system codes, partly because of new requirements in regulations of some countries as part of the NPPs licensing processes. This is so far not the case for SA codes and only a few investigations have been focused on SA and UQ. MUSA has an “innovative research agenda” in order to move beyond the state-of-the-art regarding the predictive capability of SA analysis codes by combining them with the best available or improved UQ tools. By doing so, not only the prediction of timing for the failure of safety barriers and of radiological Source Term (ST) will be possible, but also the quantification of the uncertainty bands of selected analysis results, considering any relevant source of uncertainty, will be provided. Objective of the MUSA project Assess the capability of SA codes when modelling reactor/ SFP accident scenarios of GEN II, GEN III designs Identification of UQ methodologies to be employed, with emphasis on the effect of both existing and innovative SAM measures on the accident progression, particularly those related to the ST mitigation Determination of the state-of-the-art prediction capability of SA codes regarding the ST that potentially may be released to the external environment, and to the quantification of the associated code’s uncertainties applied to SA sequences in NPPs and SFPs MUSA Work Packages WP WP MUSA COordination (MUCO), coordinated by CIEMAT WP2 Identification & Quantification of Uncertainty Sources (IQUS), coordinated by GRS WP3 Review of Uncertainty Quantification Methods (RUQM), coordinated by KIT WP4 Application of Uncertainty Quantification Methods against Integral Experiments (AUQMIE) by ENEA WP5 Uncertainty Quantification in the Analysis and Management of Reactor Accidents (UQAMRA) by JRC WP6 Uncertainty Quantification and Innovative Management of SFP Accidents (IMSFP) by IRSN WP7 COmmunication & REsults DISsemination (COREDIS) coordinated by UNIPI Dissemination of Knowledge Special attention for knowledge transfer towards young researchers and Masters/PhD students Production of public learning modules to be published in the MUSA open website. Mobility programme under which university students and young researchers go to internship programmes Production of a lecture on “Uncertainty Quantification in Severe Accident Analyses” for the different international Courses that might be given on Severe Accidents and/or on "uncertainties" MUSA Education activities will be carried out in a close collaboration with the ENEN Network Perspectives MUSA will mean a better exploitation of research previously performed within the EU framework Over the years, reliable and experienced teams of modellers and analytical teams have been built-up, and MUSA is an unique opportunity to achieve real feedback among them In addition, MUSA encourages cooperation in research, innovation and young generation’s formation Finally, MUSA will be an open results project for its importance on forthcoming SA analyses CONTACT: Pr


Urban Growth: Effects on urban green spaces and implications for planning and policy Marta Vallejo, MACS, Heriot-Watt University Supervisor: David W. Corne How to apply a Genetic Algorithm to a Sequential Planning Problem GREEN AREAS GENETIC ALGORITHM STATISTICAL DATA Metric: POPULATION SATISFACTION PROBLEM MODEL PROCEDURE RESULTS Agent-Based Modelling – Cellular Automata POLICIES & GUIDELINES Description: Cellular Automata model a city and its surroundings. Each cell has an ecological random value. The city growth has a negative effect on these values. The city is populated with a set of agents which represent families and are modelled by the use of an Agent-Based approach. E-mail: mv59@hw.ac.uk PGR Student Poster Day - 23rd August 2012 Objective: Distributing a set of green areas throughout the city and achieving the maximum satisfaction from the inhabitants of the city. An agent is satisficed if it lives close enough of one of these areas. GA should deal with future uncertainty: need the support of external tools (Statistical Data) Experiments still in progress. Preliminary data indicates a positive improvement in the satisfaction of the population using a GA-Statistical approach. Next steps: · Include new metrics like preserve most valuable ecological areas · Increase the complexity of the model to get closer to real-world scenarios · Validate the strategy followed by the comparison with other approaches commonly used for sequential planning problems like Reinforcement Learning.


Innovative Research for a Sustainable Future www.epa.gov/research ORCID: 0000-0002-4024-534X John Wambaugh l wambaugh.john@epa.gov l 919-451-5400 Product Deformulation to Identify Exposure Pathways for ToxCast Chemicals John Wambaugh1, Alice Yau2, Katherine Phillips3,4, Kristin A. Favela2, Chantel Nicolas1,4, Derya Biryol3,4, Christopher Grulke1,5, Ann M. Richard1, Paul Price3, Antony Williams1, Kristin Isaacs3, Russell Thomas1 National Center for Computational Toxicology1 and National Exposure Research Laboratory3, U.S. Environmental Protection Agency, Office of Research and Development Southwest Research Institute2, Oak Ridge Institute for Science and Education4, Lockheed Martin5 Abstract Introduction Results Estrogen Actives and Flame Retardants Summary High throughput screening (HTS) data that characterize chemically induced biological activity have been generated for thousands of chemicals by the US interagency Tox21 and the US EPA ToxCast programs. In many cases there are no data available for comparing bioactivity from HTS with relevant human exposures. The EPA’s ExpoCast program is developing high-throughput approaches to generate the needed exposure estimates using existing databases and new, high-throughput measurements. The exposure pathway (i.e., the route of chemical from manufacture to human intake) significantly impacts the level of exposure. The presence, concentration, and formulation of chemicals in consumer products and articles of commerce (e.g., clothing) can therefore provide critical information for estimating risk. We have found that there are only limited data available on the chemical constituents (e.g., flame retardants, plasticizers) within most articles of commerce. Furthermore, the presence of some chemicals in otherwise well characterized products may be due to product packaging. We are analyzing sample consumer products using 2D gas chromatograph (GC) x GC Time of Flight Mass Spectrometry (GCxGCTOF/MS), which is suited for forensic investigation of chemicals in complex matrices (including toys, cleaners, and food). In parallel, we are working to create a reference library of retention times and spectral information for the entire Tox21 chemical library. In an examination of five plastic children’s toys, as many as 114 and as few as 56 chemicals were identified in each toy, with between 0 and 40 unidentified chemicals in each. Putative endocrine disrupter, Bisphenol A (BPA), was identified as present in a product marked “BPA free”. Information on chemical constituents of products, while only a prerequisite to actual exposure, provides heuristics for estimating likely human exposure pathways for thousands of chemicals. Methods Example: Chromatograms for Baby Toys [solvent tail] is is is is is s s s s s s s is [solvent tail] is is is is is s s s s s s s is [Column bleed] [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s [solvent tail] [Column bleed] is is is is is is s s s s s s s is = internal standard s = surrogate Product 1 Product 2 Product 3 Product 4 Product 5 Retention Time First Dimension (s) Retention Time Second Dimension (s) 100x 10x 1x DCM Dilution • Southwest Research Institute conducted analytical chemistry screening for large numbers of chemicals in consumer products and articles of commerce • Five sample products were arbitrarily selected from each of twenty different categories • Products were analyzed using two dimensional gas chromatograph (GC) x GC Time of Flight Mass Spectrometry


Kelle Cruz (CUNY, NY, USA), William J. Cooper (U. of Hertfordshire, UK), David R. Rodriguez (STScI, MD, USA), Sherelyn Alejandro (CUNY, NY, USA), Ella Hort (Pomona College, CA, USA), Clémence Fontanive (U. of Bern, Switz.), Niall Whiteford (American Museum of Natural History, NY, USA) The SIMPLE Archive project — the Substellar and IMaged PLanet Explorer Archive of Complex Objects — is an endeavor to create a collaboratively maintained database of low-mass stars, brown dwarfs, and directly-imaged planetary mass objects using GitHub, Python, and SQL. Contribute The vision for SIMPLE is that anyone can contribute data using a typical GitHub workflow. The chart below illustrates the workflow from inserting new data to a local database instance via Python, review of database modifications in GitHub, and then publishing them to the website. Please join the #simple-db-dev channel in the Astropy Slack workspace for data contribution and development discussion. Develop •Work on local instance •Export to JSON •Commit to branch Review •Issue pull request •Run validation tests •Merge changes Publish •Run GitHub actions •Load DB from JSON •Deploy to website The SIMPLE Archive http://simple-bd-archive.org/ A collaboratively-curated database and website of low mass stars, brown dwarfs, and exoplanets Holdings The SIMPLE Archive currently contains over 3,000 sources, including directly imaged planets and UCDs with spectral types M7 and later. SIMPLE-AstroDB/SIMPLE-db/ SIMPLE-AstroDB/SIMPLE-web/ #simple-db-dev on astropy.slack.com/ http://joinslack.astropy.org/ Explore and Search • Website: search by object name, coordinates, or full text. • Python: SQL searches using astrodbkit2. This material is based upon work supported by the National Science Foundation under Grant No. AST-1909837. • DBBrowser: Browse data using a GUI and/or SQL. For these 3,000 sources, it contains: • 11,638 photometry measurements • 4,897 proper motion measurements • 2,628 parallax measurements • 1,404 spectra


https://zarr.dev zarr-developers @zarr_dev bioimaging distributed and cloud storage geospatial chunked storage allows parallelized access and computation data science built-in compression The Zarr specification and implementations are governed by an open process. Specification changes are suggested via Zarr enhancement proposals (ZEP). Those are reviewed and voted on by the Zarr Implementors Council (ZIC) and Zarr Steering Council (ZSC). https://zarr.dev/zeps Governance process Broad Compatibility, based on a Common Specification Funding provided by the Zarr is a Sponsored Project of Confocal imaging of mouse blastocysts Skin Layers Dermis and Epidermis Neuroglancer Napari webKnossos Atmospheric Conditions from the Coupled Model Intercomparison Project Phase 6 (CMIP6) Usage Examples Example of a Bioimaging Dataset Streamed with Zarr Chunking and Compression compatible with NEUROGLANCER INTERACTIVE NOTEBOOK https://bit.ly/3QsmI1M compatible with Chunked, Compressed N-Dimensional Arrays Josh Moore German BioImaging e.V. (NFDI4BIOIMAGE) @notjustmoore josh@openmicroscopy.org


a School of Civil, Environmental and Mining Engineering, University of Adelaide, SA, Australia b Hydrology and Atmospheric Sciences, University of Arizona, Arizona, USAFenner School of Environment, Australian National University, Canberra, SA, Australia d College of Science and Engineering, Flinders University, SA, Australia e Bren School of Environmental Science & Management, UC Santa Barbara, CA, USA Virtual Hydrological Laboratories: Developing the next generation of conceptual models to support decision-making under change Mark Thyer (a), Hoshin Gupta (b), Seth Westra(a), David McInerney(a), Holger Maier(a), Dmitri Kavetski(a), Tony Jakeman(c), Barry Croke(c), Craig Simmons(d), Margaret Shanafield(d) , Daniel Partington(d), Christina Tague(e) Lead Author Email: mark.thyer@adelaide.edu.au Presenting Author Email: Tony.Jakeman@anu.edu.au 1. Conceptual models commonly used in practice, but may provide poor predictions of future hydrological change J4. Hydrologic non-stationarity and extrapolating models to predict the future • Conceptual models (see Figure 1) are the most common type of surface hydrological model used for decision-making (Peel and McMahon, 2020) • Due to suitable predictive performance, ease of use and computational speed which facilitates scenario/sensitivity/uncertainty analysis • They have significant limitations in their ability to capture the wide range of hydrological changes (see Figure 2) (Partington et al, 2022, Fowler, et al, 2022) Figure 1: ‘End-Member’ types on the spectrum of hydrological models 2. Developing next generation of conceputal models: Hydrological Lines of Evidence (HLE) Figure 2: Range of Drivers of Hydrological Change Robustness in terms of (1) Predictive Ability: accurate predictions of observations (2) Hydrological Fidelity: Capture key processes under change 3. Emerging HLE: Virtual Hydrological Laboratory 4. Evaluation of hydrological lines of evidence to provide conceptual models robust to future change Key Question(s): Can the HLE evaluate for “robustness” for 1. Catchments of practically relevant size (100’s to 10,000’s km2) 2. Catchments with diverse range of different properties 3. Wide range of process/predictions (not just streamflow, but also ET, soil moisture etc) 4. Using real observed data 5. Robustness to “Significant” Change – see Table 1 (below) for different approaches to evaluating change 5. Unique Strengths of Virtual Hydrological Laboratory to Accelerate Development of Conceptual Models 1. Conceptual model development informed by wide range of processes In a virtual catchment all hydrological components can be observed (albeit virtually), and conceptual models can be subjected to a higher level of scrutiny than current observational datasets allow. 2. Enables the use of controlled hydrological change experiments Ability to systematically change climate and land cover/use characteristics provides opportunity to undertake hydrological change experiments and pro-actively evaluate CMs on a wide range of future hydrological change scenarios that are outside the envelope of observations. 3. Integrate Multiple Hydrological Lines of Evidence A VHL provides the opportunity to integrate multiple lines of evidence (Figure 4) thereby overcoming their respective strengths and weaknesses to build the next generation of conceptual models 6. Call to Action Predictive skill in hydrology is confronted by rapid and multi-faceted change. Our current suite of conceptual models have limited ability to deal with change. New thinking will be needed as hydrological systems are being pushed outside the envelope of historical experience “Virtual Hydrological Laboratories” provide a unique opportunity to 1. Undertake “controlled experiments” to evaluate robustness to future change 2. Complement (and integrate) existing “Hydrological Lines of Evidence” 3. Lead to new generation of conceptual models that are (i) Robust to change (ii) Embody best science (iii) Workhorse for practical decisio


Presenter: Dr Dawn C. Rose Parkinson’s is an incurable brain condition that affects people’s movement and mood. As the disease progresses, more care is required impacting on the caregivers quality of life. Research Question: Does participating in activities together improve quality of life for caregivers of people with Parkinson’s? Mixed methods: focus group (n=4), interviews (n=8) and survey (n=75, 16 male). Results 63% Parkinson’s caregivers jointly participated in a large variety of activities Impact seemed gendered: Male caregivers reported better levels of personal care, and less anxiety, depression and stress in general. Significantly higher levels of stress revealed for females not participating in activities with the person they care for. Type of activity did not seem to impact quality of life. Authors: Lia Prado (MSc.) Rebecca Hadley (PhD.) University of Hertfordshire, UK, Dawn C. Rose (PhD.) Lucerne University of Applied Sciences and Arts, Switzerland Acknowledgments: The Parkinson’s Advisory Team (University of Hertfordshire), and caregivers of people with Parkinson’s who took part in this study. Taking Time: Carer Participation and Quality of Life APA Ref: Prado, L., Hadley, R., & Rose, D. (2020). Taking time: a mixed methods study of Parkinson’s disease caregiver participation in activities in relation to their wellbeing. Parkinson’s Disease, 2020. https://doi.org/10.1155/2020/7370810 Reasons Against… Working Taking time for self Seeing other friends Prefers other activities Promoting independence (both) Reasons For… Exercise Socialising Together Time Not enough time Empathetic Safe Space Qualitative Evidence “I just need to think about myself a bit and not always be worrying, so now when she goes out I feel that I can just relax… So to just have a morning that I don’t have to think about that it is actually quite nice. It sounds very selfish.” “I think the interesting thing is that you lose a lot of friends, because actually they don’t understand it at all.” “We both go to Parkinson’s UK. I also committed to the support group because we got Parkinson’s. It is something that we both need to cope with and we need people who understand what we are going through” 0 20 40 60 80 Physical Social Home-based entertainment Daily acitvities Types of Activities and % Participation Male Carers Female Carers 0 20 40 60 Personal and Social Activities Anxiety and Depression Self-care Stress Factors of Wellbeing and % Quality of Life Compromised Male Carers Female Carers


Latest Results of Reactor Antineutrino Flux and Spectrum at Daya Bay - Antineutrino detected by inverse beta reaction (IBD) in Gd-loaded liquid scintillator • Prompt e+ signal : 1-10 MeV, determined by antineutrino energy • Delayed neutron capture signal: 8 MeV @ Gd • Time correlation: capture time is about 28 μs in 0.1% Gd-LS XXVIII International Conference on Neutrino Physics and Astrophysics, Heidelberg, 4-9 June 2018 Liang Zhan, Institute of High Energy Physics, Beijing on behalf of the Daya Bay Collaboration Reactor Antineutrinos at Daya Bay • Six reactors with a total thermal power of 17.4 GW • Antineutrino flux produced by fissions of isotopes: 235U, 238U, 239Pu , and 241Pu • Reactor operator provides generated thermal power (Wth) and fission fraction (fi /F) • ei : Energy release per fission for isotope i • Si(E): Antineutrino energy spectrum for each isotope • αi : fission fraction Abstract The latest measurement of the reactor antineutrino flux and energy spectrum by the Daya Bay reactor neutrino experiment is reported. The antineutrinos were generated by six 2.9 GWth nuclear reactors and detected by eight antineutrino detectors deployed in two near (500 m and 600 m flux-weighted baselines) and one far (1600 m flux-weighted baseline) underground experimental halls. An improvement on the neutron detection efficiency determination was performed using a new neutron calibration campaign and dedicated data-simulation comparison. With a 1230-day data set, the IBD yield was measured to be (5.91±0.09)x10-43cm2/fission. The ratio between the measured to predicted reactor antineutrino yield is 0.952±0.014(exp.)±0.023(model). The comparison of the measured IBD positron energy spectrum with the predictions is also reported with a previous 621-day data set. A reactor antineutrino spectrum weighted by the IBD cross section is extracted for model-independent predictions. Reactor Antineutrino Detection S: antineutrino flux from reactors σ: cross section of inverse beta decay. L: baseline, surveyed with a precision of 28 mm. Psur : antineutrino survival probability, including the fit parameter sin22θ13 Np: number of target protons, determined by target mass. Є: detection efficiency - Antineutrino spectrum of IBD reactions An improvement on the determination of the neutron detection efficiency was performed compared with previous publication Reactor Antineutrino Flux Measurement - Determination of the neutron detection efficiency was improved using a new neutron calibration campaign and dedicated data-simulation comparison. - An extensive neutron calibration campaign was carried out in Daya Bay at the end of 2016. Two types of neutron sources ( 241Am-13C and 241Am-9Be) were deployed vertically in three calibration axis and the data in 59 different combinations of sources and locations was collected. - A benchmark quantity was defined on the neutron capture energy spectrum. - Good agreement between calibration data and simulation on the energy spectrum and F. - The neutron detection efficiency was determined to be (81.48%±0.60%) with a reduction in the uncertainty by 56%. - A new measurement on the reactor antineutrino yield was performed using the 1230-day data which has average fission fractions of (0.571, 0.076, 0.299, and 0.054) for (235U, 238U, 239Pu , and 241Pu) Reactor Antineutrino Spectrum Measurement - Measured IBD prompt energy spectrum vs. prediction after normalization - Obvious discrepancy between data and prediction, significance was evaluated. - 3 σ for the whole spectrum - 4.4 σ for a 2-MeV energy window around 5 MeV - Uncertainty of the prompt energy spectrum - An antineutrino spectrum of IBD reactions is provided as an input for reactor neutrino experiments after unfolding the IBD prompt energy spectrum to antineutrino energy. - Consistent results by two unfolding methods: singular value decomposition (SVD) and Bayesian iteration Reactors: D1, D2, L1, L2, L3, and L4 Detectors: AD1, AD2, …, AD8 - A variety of simulati


I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 Adaptive admittance control for a safe and efﬁcient human-robot interaction Federica Ferraguti, Chiara Talignani Landi, Lorenzo Sabattini, Marcello Bonf`e, Cesare Fantuzzi and Cristian Secchi Abstract— The possibility of adapting online the way a robot interacts with the environment is becoming more and more important. Nevertheless, stability problems arise when the environment (e.g. the human) the robot is interacting with gets too stiff. In this work, we present a strategy for handling the stability issues related to a change of stiffness of the human arm during the interaction with an admittance-controlled robot. I. INTRODUCTION One of the most revolutionary and challenging features of the new generation of robots is physical human-robot interaction (pHRI). In pHRI tasks, robots are designed to coexist and cooperate with humans in applications such as assisted industrial manipulation, collaborative assembly, domestic work, entertainment, rehabilitation or medical ap- plications. In these contexts, due to the desired coexistence of robotic systems and humans in the same workspace, main concerns are related to safety and dependability. A widely used approach consists in implementing interaction control strategies that guarantee a compliant behavior of the robot. In particular, admittance control is typically utilized for controlling industrial robots, that are generally characterized by a stiff and non-backdrivable mechanical structure [1]. For example, admittance control has been used to imple- ment robot manual guidance in [2] and [3], by means of the “walk-through programming” where the human operator becomes the teacher that physically guides the robot through- out the desired trajectory. When using admittance-controlled robots, instability can arise when interacting with stiff envi- ronments. Since humans are dynamic systems characterized by a time-varying impedance, they can behave in a stiff way and, consequently, give rise to instability when interacting with admittance-controlled robot. Instability induces, among other undesired effects, a deviation of the robot from the desired admittance behavior. Furthermore, it produces high amplitude oscillations of the end-effector, undermining the user safety during the interaction. The deviations have to be ﬁrst promptly detected and then canceled (or reduced) to restore the stability of the system. The adaptation of the parameters of the admittance control is a common strategy for recovering the stability of the interaction as shown, e.g., in [4], [5] and [6]. In this work we show a novel strategy F. Ferraguti, C. Talignani Landi, L. Sabattini, C. Fantuzzi and C. Secchi are with the Department of Sciences and Methods for Engineering (DISMI), University of Modena and Reggio Emilia, Italy {name.surname}@unimore.it M. Bonf`e is with the Engineering Department, University of Ferrara, Italy marcello.bonfe@unife.it for detecting the rise of oscillations during the interaction between a human and an admittance-controlled robot and a parametric adaptation of the admittance for restoring a stable behavior. The proposed adaptation allows to keep the adaptive dynamics similar to the nominal one in order to avoid unbalancing effects and to increase the usability of the system. Preliminary results have been presented in [7] and [8], while in [9] a method for automatically setting the detection threshold using a thorough statistical analysis has been introduced. Moreover, a weighted energy allocation strategy has been proposed in order to consider separately translations and rotations. In this work we present the overall framework and we show the experimental validation of the control architecture. II. ADAPTIVE ADMITTANCE CONTROL The goal of the admittance control is to force the robot to behave in a desired way when interacting with the en- vironment. In this paper, we address the case of a robotic manipulator manuall


GALAXY CLUSTERS IN THE CFHTLS SARRON F. MARTINET N. ADAMI C. DURRET F. INSTITUT D’ASTROPHYSIQUE DE PARIS (IAP) ARGELANDER-INSTITUT FÜR ASTRONOMIE, BONN LABORATOIRE D’ASTROPHYSIQUE DE MARSEILLE (LAM) INSTITUT D’ASTROPHYSIQUE DE PARIS (IAP) Florian Sarron PhD student IAP (Paris) GALAXY EVOLUTION ACROSS TIME 12-16 JUNE 2017 There is a degeneracy between mass and redshift : only most massive clusters are detected at high redshift. Figure 6 shows the ETGs and LTGs fraction as a function of redshift for different cluster masses. The evolution in redshift for the full mass range is dominated by low mass clusters - the size of our sample enables us to study dependence on both parameters simultaneously. Fraction of ETGs and LTGs 0 0.2 0.4 0.6 0.8 1 0.2 0.4 0.6 Galaxy type proportion mean cluster redshift all M200 0.2 0.4 0.6 mean cluster redshift 1013.5 < M200 < 1014 Msun 0.2 0.4 0.6 mean cluster redshift 1014 < M200 < 1014.5 Msun 0.2 0.4 0.6 mean cluster redshift M200 > 1014.5 Msun NEXT : BREAKING THE REDSHIFT-MASS DEGENERACY Figure 6 There is some disagreement in the literature concerning the evolution with redshift of the galaxy luminosity function (GLF) in galaxy clusters. It is unclear whether the red sequence (RS) is enriched by efﬁcient quenching of blue late-type galaxies inside the cluster from z~1, or if this RS is built at higher redshift. To explore this issue, we apply our new version of the Adami and MAzure Cluster FInder (AMACFI) to the Canada France Hawaii Telescope Legacy Survey (CFHTLS) W1 ﬁeld. Figure 3 Schechter t parameters evolution for ETGs -1 -0.5 0.3 0.6 α zclus -23 -22.5 0.3 0.6 M* zclus passive evolution - BC03 -1 -0.5 13.5 14 14.5 15 α log(M200/Msun) -23 -22.5 13.5 14 14.5 15 M* log(M200/Msun) RESULT : ETGs GLFs faint end shows a mild decrease with redshift at 4.8 - meaning galaxies in clusters are efﬁciently quenched from z ~ 0.7. From the mass dependance we can infer that quenching is more efﬁcient in denser environments. σ 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.79 ± 0.02 M*early=−22.64 ± 0.07 Galaxies / deg2 Mabs(i) 142 clusters at <z>= 0.22 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.80 ± 0.03 M*early=−22.82 ± 0.06 Galaxies / deg2 Mabs(i) 264 clusters at <z>= 0.30 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.74 ± 0.03 M*early=−22.78 ± 0.05 Galaxies / deg2 Mabs(i) 327 clusters at <z>= 0.40 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.61 ± 0.03 M*early=−22.63 ± 0.05 Galaxies / deg2 Mabs(i) 366 clusters at <z>= 0.49 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.55 ± 0.04 M*early=−22.60 ± 0.05 Galaxies / deg2 Mabs(i) 370 clusters at <z>= 0.60 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.58 ± 0.05 M*early=−22.69 ± 0.06 Galaxies / deg2 Mabs(i) 344 clusters at <z>= 0.68 Figure 5 - Same as Figure 4 for stacks in bins of redshift of cluster GLFs. 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.62 ± 0.06 M*early=−22.76 ± 0.07 Galaxies / deg2 Mabs(i) 453 clusters at <M200>= 6.74E+13 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.90 ± 0.07 M*early=−22.79 ± 0.10 Galaxies / deg2 Mabs(i) 91 clusters at <M200>= 4.50E+14 1 10 100 1000 10000 −28 −26 −24 −22 −20 −18 −16 αearly=−0.87 ± 0.03 M*early=−22.89 ± 0.05 Galaxies / deg2 Mabs(i) 622 clusters at <M200>= 1.71E+14 Figure 4 - Stacks in bins of mass of cluster GLFs. Best fit of Schechter parameters of ETGs is indicated. Vertical line is the 90% completeness limit of the sample - corresponding to i=23 in apparent magnitude. Composite GLFs of cluster candidates 0 0.2 0.4 0.6 0.8 1 0.3 0.6 0.9 Completeness zhalo Completeness for M200 > 1014 Msun 0 0.2 0.4 0.6 0.8 1 1 2 3 4 5 6 Completeness M200,halo [1014 Msun] Completeness for M200 > 1014 Msun 0.6 0.8 1.0 0.3 0.6 0.9 Purity zphot Purity for M200 > 1013 Msun S/N > 3 S/N > 4 S/N > 5 13.0 13.5 14.0 14.5 15.0 0.3 0.6 0.9 log(M200/Msun) zphot SN > 4 13.0 13.5 14.0 14.5 15.0 0.3 0.6 0.9 0 0.2 0.4 0.6 0.8 1 We apply AMACFI to


Databases and web-based software tools for HR-pyPopStar models and MEGASTAR library Mollá Lorente, M. 1 ; García-Vargas, M. 2; Carrasco Licea, E. 3; Mujica Álvarez, E. 2 & Millán-Irigoyen, I. 1 1CIEMAT (Madrid, Spain), 2FRACTAL S.L.N.E. (Madrid, Spain), 3INAOE (Puebla, Mexico) MEGASTAR is a stellar spectral atlas for MEGARA (Multi Espectrógrafo en GTC de Alta Resolución para Astronomía). MEGARA is an optical (3650 – 9750 Å), fiber- fed, medium-high spectral resolution (R = 6000, 12000, 20000) instrument in operation on the GTC 10.4m telescope. The scientific exploitation of MEGARA demanded a stellar-spectra library to interpret galaxy data and to estimate the contribution of the stellar populations. MEGASTAR atlas is focused on the highest resolution setups, HR-R and HR-I, and already has almost 1000 stars (twice spectra) thanks to the filler-type OpenTime obtained up to now in 7 semesters. We have developed a web- based tool and a database that allow working in the project (for MEGASTAR team) and making the observations and products available to the scientific community. MEGASTAR WebApp Functionalities: § Visualization and search of the sources involved in the project (link to the SIMBAD database). § Visualization, search, download and plot the data product files (by using a java tool) of the observations. § Paint a graph of the stars grouped by three ranges of [Fe/H] as follows: all stars of the library, the observed stars of the library or the user stars uploaded by a file. § Download the releases of the reduced star spectra. § Download the statistics files: observations statistics by VPH and by stellar physical parameters. MEGASTAR WebApp Technologies: § Web Servers: Apache and Tomcat § Database: MySQL § Languages: Java, Java Servlets, HTML and JavaScript § Libraries: JFreeChart, Plotly and nom.tam FITS HR-pyPopStar WebApp Functionalities: § Detailed description of the HR-pyPopStar models. § Models Download. § Plot spectra from the HR-pyPopStar Library. § Plot synthetic properties resulting from SSP SEDs. § Combine spectra from the HR-pyPopStar Library. HR-pyPopStar WebApp Technologies: § Web Servers: Apache and Tomcat. § Database: MySQL. § Framework: Google Web Toolkit (GWT). § Languages: Java, Java Servlets, HTML and JavaScript. § Libraries: JFreeChart and nom.tam FITS. HR-pyPopStar model provides a complete set of high resolution (HR) Spectral Energy Distributions (SEDs) of Single Stellar Populations. The model uses the most recent high wavelength-resolution theoretical atmosphere libraries for main sequence, post-AGB/planetary nebulae and Wolf-Rayet stars. The SEDs are given for more than a hundred ages ranging from 0.1 Myr to 13.8 Gyr, four different values of the metallicity (Z = 0.004, 0.008, 0.02 and 0.05), and four different IMFs. We have developed a public web-based software tools and a database to manage HR-pyPopStar models and to make this available to the users community. References: García-Vargas et al. , 2020, MNRAS, 493, 871. DOI: 10.1093/mnras/staa126; Carrasco et al., 2021, MNRAS, 501, 3568. DOI: 10.1093/mnras/staa3704; Mollá et al. 2022, submitted. References: Millán-Irigoyen et al. (2021), MNRAS, 506, 4781. https://doi.org/10.1093/mnras/stab1969


SCHOOL OF ROCK 2016 UN’INSEGNANTE ITALIANA SULLA JOIDES RESOLUTION Cicconi A. 1,2 1. Liceo Scientifico “G. Marinelli”, Udine; 2. School of Science and Technology, University of Camerino, Camerino COSA TROVERETE IN QUESTO POSTER Lo scopo di questo poster è raccontare l’esperienza della prima insegnante italiana a bordo della Joides Resolution per partecipare ad un corso di formazione per docenti di Scienze: School of Rock. Attività sulla Joides Resolution LEZIONI IN AULA Ogni giorno sono state svolte diverse ore di lezione teorica al fine di costruire le basi per la comprensione di complicati articoli scientifici sulla paleoclimatologia delle carote di sedimento oceanico. A TU PER TU CON LE CAROTE Ricercatori esperti nel settore ci hanno mostrato come vengono analizzate le carote di sedimento raccolte dalla Joides Resolution. VETRINI…VETRINI…E ANCORA VETRINI … JOIDES RESOLUTION La Joides Resolution è una nave oceanografica per carotaggi sul fondale marino. La nave è proprietà della società Siem Offshore AS ma lavora per IODP (International Ocean Discovery Program). Gli scienziati che lavorano sulla JR vengono da tutto il mondo. In ogni spedizione, sulla nave, è presente un docente di scienze che si occupa della divulgazione. … IODP L’International Ocean Discovery Program è un programma di ricerca che vede la collaborazione di 25 Nazioni. Lo scopo è quello di studiare la storia e la dinamica della Terra a partire dallo studio dei fondali oceanici. Il piano scientifico 2013-2023 ha un titolo più che significativo: «Illuminating Earth’s Past, Present and Future» Sponsor principali di questo programma sono: la National Science Foundation (USA), Il Ministero dell’Educazione, Cultura, Sport, Scienza e Tecnologia (JAPAN) e l’ ECORD (European Consortium for Ocean Research Drilling). … SCHOOL OF ROCK School of Rock è un corso di formazione per docenti organizzato da IODP con lo scopo di divulgare, creando dei docenti esperti, le attività di ricerca che si svolgono sulla JR. Nel 2016 sono stati selezionati 16 docenti di cui 14 Statunitensi, una docente Francese e per la prima volta una docente Italiana. … DOCENTI E RICERCATORI INSIEME! La caratteristica di School of Rock che ne fa un corso di aggiornamento per docenti di elevato valore formativo sia dal punto di vista didattico ma anche scientifico è la presenza, come formatori, di ricercatori attivamente coinvolti nelle spedizioni di Joides Resolution. Gli insegnanti li hanno affiancati nell’analisi delle carote di sedimento e nella lettura dei dati proprio come dei veri ricercatori. CONNESSI CON IL RESTO DEL MONDO Ogni giorno i docenti hanno gestito un Blog sulle attività svolte sulla nave o all’esterno nonché aggiornato la pagina Facebook e Twitter. Inoltre sono stati organizzati collegamenti con scuole dei propri Paesi. FACCIAMO LA CONOSCENZA CON… Nella foto a sinistra il ricercatore Larry Krissek della Ohio State University ed io che lo intervisto e trasmetto con un tablet ad una classe collegata dall’Italia (foto a destra). SCHOOL OF ROCK 2016 DOVE All’interno della Joides Resolution ancorata al porto di Cape Town (Sud Africa). QUANDO Dal 29 Maggio al 6 Giugno 2016. CHI 16 docenti di scienze di cui 14 Statunitensi, una docente Francese ed una docente Italiana. COSA Exploring Ocean Cores and Climate Connections: From Antarctica Across the Southern Ocean. L’Antartide è stato sempre coperto dai ghiacci? L’estensione del ghiaccio marino è stata sempre la stessa? Quali informazioni si ricavano dalle carote di sedimento oceaniche estratte nell’Oceano Meridionale? Come si interpretano i dati relativi ai fossili presenti nelle carote? Come è cambiato il clima nel passato della Terra? Questi sono stati alcuni degli interrogativi a cui si è cercato di dare una risposta esclusivamente utilizzando i dati ricavati dalle carote (Data Driven Education) utilizzando quindi lo stesso procedimento di indagine usato dagli scienziati. Le escursioni sono state guidate da docenti dell’Università di


2D Two-Temperature Model Numerical Study Of Formation Mechanisms Of Periodic Surface Structures Induced On Silicon Under Femtosecond Laser Irradiation T. JY. Derrien1, R. Torres1, T. Sarnet1, M. Sentis1, T. E. Itina2 1 Lasers, Plasmas and Photonic Processes Laboratory (LP3 UMR 6182 CNRS), 163 av. de Luminy, Case 917, 13288 Marseille, France 2 Hubert Curien laboratory, UMR CNRS 5516/Université Jean Monnet, 18 rue du Professeur Benoit Lauras, 42000, Saint Etienne, France Contacts PhD std: thibault.derrien@lp3.univ-mrs.fr CNRS researcher: tatiana.itina@univ-st-etienne.fr Surface wave investigations Context Lifetime of a fs interference in Si Does melting occur under fs pulse on Si ? CINES computational center and French Ministry of Research PhD support are gratefully acknowledged. Additional thanks to D. Grojo, I. Bogatyrev, and A. Nikitin. « Spikes » Black silicon. « Agregation » Amplification Increasing number of 100 fs, 1 kHz shots « Ripples » LIPSS « Beads » Saturation Problem: Formation mechanisms are not well-known. -- Objective: Identify the mechanisms of : 1. Periodic modification of the electron-hole plasma created by femtosecond laser irradiation 2. Transmission of the pattern from electrons to lattice 3. Change of order and amplification of the nanostructures Interplay between Electron-lattice coupling and Diffusion of Electrons Conclusion Fusion Resolidification Recrystallisation References. - ~45 nm melted and resolidifcated depth (0.42 J/cm2, 130 fs) [J. Bonse, Applied Surface Science 221, 215 (2004)] - Melting occurs from 0.2-0.5 J/cm2 [NM Bulgakova, Physical Review B 69, 054102 (2004)], [DP Korfiatis, Journal of Physics D 40, 6803 (2007)] Bulk silicon Melting starts at ~0.4 J/cm². ~115 nm melted at 0.5 J/cm². Laser fluence (J/cm²) Electron temperature Free – carrier density Lattice temp. Melting Critical density Model includes: •Electron and Lattice temperatures (heating, coupling, diffusion, cooling). •Free-electron and hole density (1-2 photon ionization, electronic avalanche, convection, recombination) •Fresnel formulas of reflectivity and inverse Bremmstrahlung absorption •Drude model (EM behaviour) •Electron-phonon and electron-electron collisions are considered. EM plasmonic interference is modeled and the possibility of printing the pattern from electrons to lattice is checked. Result is : for high fluence, convection-diffusion is dominant on electron-lattice coupling, for low-fluence, it is possible to observe a priodic modification in lattice temperature profile. On these figures, F=500 mJ/cm². Calculated free-electron density, electron and lattice temperature are presented for a 500 mJ/cm² laser fluence, 800 nm NIR wavelength, and 100 fs pulse duration (FWHM). It has been reported that c-Si (100) melts from 0.2 J/cm² under ~100 fs laser irradiation. Our calculations based on a melting temperature criterium showed that, if melting occurs, resolidifcation front velocities are higher than maximum speed of recrystallisation, thus should be observed. However, calculations based on fusion enthalpy showed that no melting occurs. Our experimental measurements show that no melting/recrystallisation front is observable on Transverse Electron Microscopy pictures of the Si-protection layer interface. - Calculations showed that thermal processes (melting, evaporation, …) are not the mechanisms responsible for pattern transmission from electron to the lattice. Ablation may occur, but an ultrafast mechanism of ablation (~200 fs at 500 mJ/cm²) is required to support the interference hypothesis. - Calculations confirm the possibility of the surface electromagnetic wave (plasmon) to be responsible for ripple formation under fs laser irradiation, through the modification of absorption provided by a seed (defects, roughness, nanoparticle) under our conditions. - Calculations and experiments show that no melting occurs during ripple formation. - Experiments show that mechanism of ripple-to-beads transition occurs in a crysta


Snip – User Centric Collaborative ELN Markus Osterhoff, Sebastian B. Mohr, Sarah Köster Georg-August-Universität Göttingen Röntgenphysik | CIDAS | SFB 1456 internet server analysis catalogue sample DB CONTROL meta data raw data experiment discussion users discussing with colleagues mobile access …! …? …!? …? conﬁg positions, parameters images, links data decisions feedback User Centric Paradigm – Documenting Non-Linear Discussions and Experiments Examples Creative, Collaborative Collage ► ►computer-generated contents (API) ► ►handcrafted annotations (pen entry) ► ►real-time communication (web based) Curated Lab Book ► ►putting the experimental state into context ► ►via API: parameters, images, URLs ► ►via pen & text: highlights, thoughts, sketches ► ►bringing machine-readable snips into perspective Closing the Loop ► ►Experiment ⇒ Thoughts ⇒ Decisions ⇒ Experiment Acknowledgements We thank Jan Goeman for outstanding technical support. Funding by Deutsche Forschungsgemeinschaft (SFB 1456), DAPHNE4NFDI and the Göttingen Campus Institute Data Science is gratefully acknowledged. API / Data Ingestion ► ►interoperable with other software: instruments send their state, users discuss and comment ► ►public JSON-endpoint accepts standardised snips: API tokens per book for authentication ► ►custom snip types: hierarchical namepaces prevent conflicts between groups Single / dual page layout Upload / place new snips Doodle tool Hyperlinks Permission system Creative collage JSON snip sci.photos/ QR/FDM24 snip. roentgen. physik.uni- goettingen. de Current Status & Outlook Client/server architecture ► ►React in TypeScript, serviced by node.js ► ►extensible and modular, custom snips and render functions In production @ GINIX X-ray microscope (DESY, Hamburg) ► ►macros send content to lab book ► ►integration into other beamlines under development In production @ IRP ► ►lab experiments, personal ELNs; shared experiments ► ►150 books, > 20k pages; ~ 30k snips, ~ 500k doodles Feature Status live update, working collaboratively yes free-form input; pen entry, sketches; images yes machine-readable data, data ingestion via API yes; namespaces and schemas permissions (r/w; API token; r/o token) yes; user-defined groups searching and filtering yes tagging system (table of contents, flags) under discussion hyperlinks to external systems yes federated login, SSO work in progress removing contents during grace period automatic creation of lab book could be implemented Snip types ► ►Basic types: image, text, doodle URLs linking to SciCat, Sample DB, PID services etc. ► ►Array: composite snips ► ►User defined types: timestamp, motor positions, macro, log, measurement, Jupyter analysis, … Book browser MariaDB page -, book -, user data, ... Render service Preview storage trigger server side rendering preview images signup pw reset Email service real time updates Websocket trigger updates static client ﬁles API requests fetch data


The characterization of the water vapor vertical distribution on Mars is currently a very active research topic. Until this last decade, the water cycle has been studied mainly with the analysis of column density abundances. The recent possibility of solar occultation (SO) observations has opened a new path towards a better understanding of the Martian climate [1]. The Mars we observe today is a dry and cold planet although there are abundant evidences suggesting a warmer and wetter environment in the past [2]. Despite being a minor species in the current Martian atmosphere (~0.03%), water vapor has a large variability throughout the year, resulting in a very complex hydrological cycle involving sublimation and condensation processes affected by dust and atmospheric transport [1]. Global Dust Storm Data analysis Supersaturation and water ice Seasonal variation Contact: adrianbm@iaa.es WATER VAPOR VERTICAL DISTRIBUTION ON MARS DURING 5 YEARS OF EXOMARSTGO/NOMAD OBSERVATIONS A. Brines1, M. A. LópezValverde1, A. Stolzenbach1, A. Modak1, B. Funke1, F. G. Galindo1, S. Aoki2,3, G. L. Villanueva4, G. Liuzzi4,5, I. R. Thomas2, J. T. Erwin2, U. Grabowski6, F. Forget7, J.J. LopezMoreno1, J. RodriguezGomez1, F. Daerden2, L. Trompet2, B. Ristic2, M. R. Patel8, G. Bellucci9 and A. C. Vandaele2 1Instituto de Astrofísica de Andalucía (IAA/CSIC), Spain; 2Royal Belgian Institute for Space Aeronomy, Belgium; 3Department of Complexity Science and Engineering, University of Tokyo, Japan; 4NASA Goddard Space Flight Center, USA 5American University, Washington DC, USA; 6Karlsruhe Institute of Technology, Karlsruhe, Germany; 7Laboratoire de Météorologie Dynamique, IPSL, Paris, France; 8Open University, UK; 9Istituto di Astrofisica e Planetologia, Italy VII Reunión de Ciencias Planetarias y Exploración del Sistema Solar Valladolid 11, 12 y 13 de julio de 2023 Here we present a summary of results about the characterization of the water vapor in the Martian atmosphere. We study its seasonal variability during 3 Martian Years (MY) analyzing almost 5 years (April 2018 to December 2022) of NOMAD SO observations. We present a detailed insight of specific periods showing the effects of dust storms and detections of supersaturation. NOMAD is an infrared spectrometer covering the spectral range between 0.2 to 4.3 µm. Its SO uses an echelle grating with with an AcoustoOptical Tunable Filter (AOTF) to select different diffraction orders to be used during the observations. The spectral resolution of the SO channel is λ/∆λ = 20,000. The sampling allows a vertical resolution of 1 km. Also, the AOTF permits probing the atmosphere at a given altitude through 6 different diffraction orders [7]. For this study, we use Level 1 SO calibrated transmittances [8] of diffraction orders 134 (30113035 cm1), 136 (30563081 cm1) for the lower atmosphere and 168 (37753806 cm1), 169 (37983828 cm1) for the upper atmosphere. We have developed preprocessing tools to identify and eliminate residual artifacts in the spectra (bending, spectral shift) using the linebyline radiative transfer algorithm KOPRA [9]. For the inversions, we use the latest calibration of the NOMAD AOTF and its instrumental line  shape (ILS) [10]. The retrievals are done combining the spectra of low altitude orders (134,136) with spectra of high altitude orders (168,169) up to 120 km for occultations where those orders where observed simultaneously. The bottom panels show two examples of typical NOMAD spectra (black) after its bending and spectral shift corrections for diffraction orders 136 (panel A) and 169 (panel B) at 30 and 100 km respectively. We also show the fitting after the retrieval (red). For optimization purposes, we only fit the data at certain spectral windows where the strongest H2O absorption lines are located. The panel on the right shows a typical retrieved H2O vertical profile (blue) and the GCM a priori used during its inversion. For this example, we are not fitting the data


References Ran E, et al. (2013) Alternative cleavage and polyadenylation: extent, regulation and function. Nature Reviews Genetics 14, 496-506. Simpson JT, et al. (2009) ABySS: a parallel assembler for short read sequence data. Genome Research 19, 1117-1123. Robertson G. et al. (2010) De novo assembly and analysis of RNA-seq data. Nature Methods 7, 909-912. Trapnell C, et al. (2010) Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nature Biotechnology 28, 511-515. Grabherr MG, et al. (2011) Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nature Biotechnology 29, 644-652. Djebali S, et al. (2012) Landscape of transcription in human cells. Nature 489, 101-108. Abreviations 3’-end – Downstream end 5’-end – Upstream end ABySS – Assembly by short sequences APA – Alternative polyadenylation CDS – Coding DNA sequence CS – Cleavage site DNA – Deoxyribonucleic acid ENCODE – Encyclopedia of DNA elements EST – Expressed sequence tag FDR – False discovery rate PET – Paired-end tag Poly(A) – Polyadenylation PPV – Positive predictive value RNA – Ribonucleic acid RNA-Seq – Whole transcriptome shotgun sequencing ROC – Receiver operator characteristic SPAT – Searching for poly(A) tails TPR – True positive rate Trans-ABySS – Transcriptome ABySS UTR – Untranslated region WIG – Wiggle format 1. Overview Acknowledgements In cancers, alternative splicing and polyadenylation (APA) can affect transcript stability, transport and translation, and can change a transcript’s translated sequence. APA can be characterized with short-read sequencing using specialized library construction methods. For large-scale disease studies, however, it is desirable to characterize splicing and APA from a single library construction and sequencing run. In the work reported here, we describe SPAT, an analysis tool that uses de novo assembly of RNA-Seq data to Search for Poly(A) Tails. SPAT is designed to accept contigs from a range of de novo transcriptome assemblers. When used with Trans- ABySS, the overall pipeline reports fusions and rearrangements, indels, alternative splicing, and a range of types of APA. SPAT: Searching for Poly(A) Tails in RNA-Seq de novo Assemblies Raymond AGJ, Robertson AG, Chiu R, Mungall K, Nip KM, Kreitzman M, Jackman SD, Karsan A and Birol I 2. RNA-Seq Assembly and Poly(A) Tail Detection RNA-PET Clusters Using data supplied by ENCODE for cell line A459, we first thresholded peaks in RNA-PET coverage tracks, then clustered peaks that occurred within 100bp of each other. We used the resulting clusters as ‘true’ events for validations and ROC-like curves. ROC-Like Curve true positive | An RNA-PET cluster with at least one CS call within 100bp. false positive | A CS call that is not within 100bp of an RNA-PET cluster. true negative | Cannot be defined. false negative | An RNA-PET cluster with no CS call within 100bp. 3. Comparing Cleavage Site Calls RNA-Seq Tools Trans-ABySS/SPAT | Assemble with Trans-ABySS and process with SPAT. Trinity/SPAT | Assemble with Trinity and process with SPAT. Cufflinks | Assemble with Cufflinks and call CSs at transcript ends. ROC-like curves, which were insensitive to thresholds for RNA-PET peak detection and clustering, show that SPAT works with other assemblers, and performs better than a method that uses annotations to determine ends of expressed 3’ UTRs. SPAT has a PPV of 90% when we require an RNA-PET coverage of 3 and 2 bridging reads supporting a CS call. Validation Counts Venn diagrams were generated with the true positives from each tool set. Increasing RNA-PET stringency reduces the number of true positives by 6% for Trans-ABySS/SPAT and 27% for Cufflinks. We thank the ENCODE consortium for supplying the resources that made this analysis possible. We gratefully acknowledge funding from Genome BC, Genome Canada, and the BC Cancer Foundation. Trans-ABySS Assembly Assembly involves constructing


KNOW W HAT YOU EAT GET THE MOBILE APP Fish supply chain traceability at your ﬁngertips, for an informed and conscious choice. NOVAFOODIES GET THE APP SCAN QR CODE DISCOVER This project has received funding from the European Union under Grant Agreement N° 101084180. © All registered trademarks and logos mentioned in this document are the property of their respective owners. Co-funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reﬂect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.


The ESCAPE project is working toward the implementation of FAIR principles for Astrophysics ESFRI by using IVOA standards in the context of connecting the Virtual Observatory framework to the European Open Science Cloud. The scientists, software engineers, and data experts from the different facilities are addressing the ‘data stewardship’ challenges for a wide range of different data products and services. The recent ESCAPE Technology Forum event identified a number of important topics in the different domains from Radio Astronomy to Solar Physics: Connecting to the European Open Science Cloud Data stewardship of next-generation data products and services related to ESFRI and other astrophysics infrastructures M. Allen1, S. Amodeo1, F. Bonnarel1, M. Molinaro2, F. Genova1, M. Romaniello3, H. Heinl1 , A. Schaaff1, S. Lesteven1 Application of IVOA standards for solar physics data: § Metadata for the semantics of the content (Unified Content Descriptors ‘UCD’ standard) § Table Access Protocol for finding and using tabular data Solar Physics Standards: § Data Provenance implementations – “Allowing users to access quality and reliability information.” § Application of IVOA Data Models § Support for multi-messenger approach (VO events, schedules, alerts) High Energy Astrophysics First steps for neutrino data in VO : § Publication of Tables § Publication of Events § Integration into multi-messenger astrophysics systems § Data provenance standards § Using VO tools (e.g. TOPCAT, Aladin) § Complementarity with the services of the KM3NeT Open Data Center Neutrino Astrophysics Standards: § Standards for discovery of interferometric data – “Make the data easy to find!” § Data provenance – “What happened to these data?” § Data models – “What metadata is needed for discovery and interoperability?” Accessing and using radio astronomy data: § Zoomable interactive access to large simulations on the sky (HiPS standard) § Access to VO services for radio data from python Radio and millimetre Astronomy § Standards and tools for GW follow-ups: § Sky coverage standards § Indexing the sky in space and time (HIPS, MOC 2.0) § See- A full presentation by G. Greco Gravitational Wave astronomy ACRONYMS ESCAPE: European Science Cluster of Astronomy & Particle Physics ESFRI Research Infrastructures ESFRI: European Strategy Forum on Research Infrastructures FAIR: Findable, Accessible, Interoperable, Reusable HiPS: Hierarchical Progressive Survey IVOA: International Virtual Observatory Alliance MOC: Multi-Order Coverage Deep learning for adding value to the ESO archive data – ”let the data speak” § e.g. search for similar spectra § See -- Sedaghat et al. 2021 Optical/UV/IR Astronomy VO standards in the ESO archive for: § linking data (Datalink standard) § image cutouts (SODA standard) § Large-scale imaging (HiPS standard) See -- Romaniello et al. 2018 ESCAPE - The European Science Cluster of Astronomy & Particle Physics ESFRI Research Infrastructures has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement no. 824064. 1 CNRS, Observatoire astronomique de Strasbourg, France 2 INAF, Osservatorio Astronomico di Trieste, Italy 3 ESO – European Southern Observatory


Accuracy assessment of MERRA-2 temperature and humidity profiles over the tropical ocean using AEROSE observations and ECMWF analysis Bingkun Luo1, Peter J Minnett1, Goshka Szczodrak1, Nicholas R. Nalli2 •Reanalysis model output is extensively used in atmospheric research to complement the satellite and in situ data. NASA's Goddard Earth Sciences Modern-Era Retrospective analysis for Research and Applications v 2 (MERRA-2) assimilates measurements from different sources to minimize bias errors. The model data must be rigorously evaluated to assess their suitability to study a variety of questions. Here, Sea Surface Temperature (SST) and profiles of temperature and humidity through the marine atmosphere from MERRA-2 are compared to independent ship-based measurements of radiosondes, and retrievals from the ship-based Marine-Atmosphere Emitted Radiance Interferometer (M-AERI), and also the analyses fields of the European Center for Medium - Range Weather Forecasting (ECMWF). The ship measurements include those from Aerosol and Ocean Science Expedition (AEROSE) cruises of the NOAA Ship Ronald H. Brown in the tropical North Atlantic Ocean, focusing on the representation of the spatial and temporal variability. The results reveal that temperature and water vapor profiles from the MERRA-2 are in good agreement with the in situ measurements. For part of the cruises, the atmosphere included a mid-level dry layer emanating from North Africa, the Saharan Air Layer (SAL). With respect to difference, MERRA-2 humidity profiles shows a big difference (40%) with RAOBs at high altitude (pressure level < 300 hPa). These results support the use of MERRA-2 fields in a variety of research applications, including those directed at improving the accuracies of satellite-derived SSTskin retrievals. Abstract The MERRA-2 SST agrees well with M-AERI, and it has a mean bias of 0.125 K and have the potential to provide a satisfactory contribution to studies involving SST. The SST difference distribution between them shows there is negative bias near equatorial region, effort is still required to provide better data especially some water vapor-contaminated data. Table: Statistics of errors of MERRA-2 SST vs M-AERI 2. SST Validation MERRA-2 datasets: The NASA MERRA-2 reanalysis data were generated using the Goddard Earth Observing System data assimilation system by NASA's Global Modeling and Assimilation Office Data Assimilation System V5.12.4. Covering the earth observation data from 1980 to present. MERRA-2 analysis data are computed on a latitude– longitude-altitude cubed sphere grid at the same spatial resolution as the 3DVAR algorithm atmospheric model based on the Grid-point Statistical Interpolation. AEROSE: • A series of intensive field campaigns on the NOAA ship Ronald H. Brown in the Atlantic Ocean. • AEROSE data include complementary measurements to study the transport of aerosols from the African continent across the Atlantic Ocean, including: –Microphysical evolution and regional impacts –Regional atmospheric chemistry and marine meteorology AEROSE tracks, color indicates the days since departure. Independent Validation data: •Radiosonde (RAOB): Balloon-based instrument to make direct in situ measurements of air temperature, humidity, and pressure to about 30 km height. • ECMWF: Contains a set of atmospheric variables on a spatial horizontal grid of 0.5ox 0.5 o at 60 vertical levels. The ECMWF analysis is produced daily for 00, 06, 12 and 18 UTC. The four analyses per day are obtained by four- dimensional variational analysis (4DVAR) schemes. • M-AERI: An accurate, self- calibrating, Fourier transform IR spectroradiometer that measures emission spectra from the sea and atmosphere. (Minnett et al. 2001). 1. Data 19th International GHRSST Science Team Meeting 4th-8th June 2018, EUMETSAT, Darmstadt, Germany Relative Humidity and temperature layer properties of RAOB, MERRA-2 and ECMWF during 2015 AEROSE cruise, color indicates RH and temperat


Holocene sea-level changes in Southeast Asia 1 2 3 4 5 1 M. Bender , T. Mann ,D. Kneer , P. Stocchi , J. Jompa , A. Rovere Sea Level & Coastal Changes SLCC Acknowedgments: This work is supported through the grant SEASchange from the Deutsche Förderungsgemeinschaft (DFG) as part of the Special Priority Program (SPP) 1889 Regional Sea Level Change and Society“ (SeaLevel). The Sea Level and Coastal Changes group research is supported by the Institutional Strategy of the University of Bremen, funded by the German Excellence Initiative [ABPZuK-03/2014] and by ZMT, the Leibniz Centre for Tropical Marine Research 1: MARUM – Center for Marine Environmental Sciences, University of Bremen, Bremen, Germany 2: ZMT – Leibniz Centre for Tropical Marine Research, Bremen, Germany 3: Alfred-Wegener-Institut, Bremerhaven, Germany 4: NIOZ Royal Netherlands Institute for Sea Research, Den Burg, Texel, Netherlands 5: Universitas Hasanuddin - Department of Marine Science Indonesia - Makassar RSL results from fossil microatolls in the Spermonde Archipelago, Indonesia, SE Asia Affiliations References modern microatoll fossil microatoll In this study we surveyed fossil microatolls on ﬁve new islands and living microatolls and compared the relative sea level (RSL) estimates with previous data provided by Mann et al., 2016. Figure 1) the locations and close- ups of the surveyed islands. Panel a-b) provide overview of study areas, sorted by letters as indicated in b). The islands Panambungan (g) and Barrang Lompo (i) were surveyed by Mann et al., 2016. The red S. indicates a third island from Mann et al., 2016 where only living microatolls are found. This island is not shown here (see ﬁgure 3 for LMA elevations). Figure 2) All related RSL curves derived from fossil microatolls and their modern counterparts. Panel a) the positions of the islands are indicated by letters and colors and correlate to RSL graphs. All islands show comparable RSL results except the data set from Barrang Lompo, which shows a noticeable low RSL curve. The two studies from De Klerk, 1982 and Tjia et al.1972 show RSL results up to 6 meter above the present sea level, whereas the new data and the data by Mann et al., 2016 show RSL results of less than one meter above today. One possible explanation is that the earlier RSL results reﬂect extreme storm or tsunami events. Additionally, the GIA predictions mismatch the data and therefore,we propose to explore diﬀerent ice models e.g. ICE-6G by Peltier et al., 2015 or ANICE ( De Boer et al., 2014). Figure 4) RSL indicator points for the Spermonde Archipelago and the ICE-5G GIA model (Peltier, 2004) and ﬁve diﬀerent mantle viscosities for the same area. The gray band indicates the lowest and highest GIA prediction for this region. Shown are two marine limiting points from Tjia et al.,1972, 16 marine and two terrestrial limiting and one index point by De Klerk,1982, 21 sea-level index points from Mann et al.,2016 and the 24 newly surveyed data points. Comparison with data from literature -0.4 -1 -0.8 -0.6 -0.2 0 Elevation [m] Sanane -1 Sanrobengi Barrang Lompo Panambungan Tambakulu n=24 n=23 n=20 n=17 n=51 Our results for the living microatoll surveys show a clear geographic trend in the HLC. The highest HLC was measured on Sanrobengi. This island is placed only one km from the coast of Southwest Sulawesi. The HLC from Sanane, Panambungan and Barrang Lompo diﬀer slighty from each other but they are within a comparable range. These islands are located in the middle of the Archipelaho. On Tambakulu the HLC signal is the lowest. It is placed at the outer part of Spermonde ~70 km from the coast of the mainland. This trend might be based on diﬀerences in the local mean sea level or partial tides from the coast to open ocean due to a deepening bathymetry. Figure 3) a boxplot of the average HLC (Height of Living Coral) of living microatolls on all surveyed locations. n= the amount of surveyed individuals. Living Microatoll survey and HLC averages


FILM SERIES “The Human Dimensions of Climate Change” Sponsored by: Fogler Library, the Climate Change Institute, Anthropology, Communication & Journalism & Political Science. The University of Maine does not discriminate on the grounds of race color, religion, sex, sexual orientation, including transgender status and gender expression, national origin, citizenship status, age, disability, genetic information or veteran’s status in employment, education, and all other programs and activities. The following person has been designated to handle inquiries regarding nondiscrimination policies: Director, Office of Equal Opportunity, 101 North Stevens Hall, 207.581.1226. Discussant Dr. Robert Glover Assistant Professor of Political Science & Honors, Cooperating Faculty Margaret Chase Smith Policy Center This Changes Everything MARCH 29 @ 6PM Library Classroom, Fogler Library Merchants of Doubt MARCH 22 @ 6PM Library Classroom, Fogler Library Discussant Dr. Laura Rickard Assistant Professor of Communication and Journalism Discussant Dr. Daniel Dixon Research Assistant Professor, Climate Change Institute UMaine Sustainability In The Path of Resistance APRIL 5 @ 6PM Library Classroom, Fogler Library


CODATA-RDA Escuelas de Ciencia de Datos para la Investigación Marcela Alfaro Córdoba, Louise Bezuidenhout, Raphael Cóbe, Sara El jadid, Bianca Peterson, Rob Quick, Hugh Shanahan, Shanmugasun- daram Venkataraman Objetivos y Alcance • Crear una cultura dentro de las instituciones de investigación de los países de ingresos bajos y medios, que se comprometa plenamente con la era de los Datos Digitales. • Escuelas regionales para enseñar habilidades fundamentales de Ciencia de Datos, diseñadas para crear comunidades de personas investigadoras que inician su carrera en países de ingresos bajos y medios, que tienen interés en practicar la Ciencia Abierta. • Plan de estudios distribuido en dos semanas de clases. • Egresados incluyen más de 500 estudiantes de más 45 países. • Planes para futuras sesiones de formación de formadores. Convocatoria abierta a ayudantes e instruc- tores para futuras escuelas regionales. Incorporación de la Ciencia Abierta • Evitamos dar recetas. • Preparamos para la realidad en casa. • Promovemos el debate reflexivo. • Proveemos ejercicios éticos integrados en cada sesión. • Mezclamos teoría con ejercicios prácticos. Currículo Incorporamos la práctica de la Ciencia Abierta en la formación en CienciadeDatos. Tome una fotografía para visitar nuestra página web Línea de Tiempo ↑ Julio 2016 • dataTrieste16 • ICTP Trieste, Italy Julio 2017 • dataTrieste17 • ICTP Trieste, Italy Diciembre 2017 • dataSaoPaulo17 • ICTP-SAIFR Sao Paulo, Brazil Julio 2018 • dataTrieste18 • ICTP Trieste, Italy Octubre 2018 • dataKigali18 • ICTP-EAIFR Kigali, Rwanda Diciembre 2018 • dataSaoPaulo18 • ICTP-SAIFR Sao Paulo, Brazil Junio 2019 • dataAddis19 • Addis Ababa University, Ethiopia Julio 2019 • dataTrieste19 and Data Stewards • ICTP Trieste, Italy Diciembre 2019 • dataSanJose19 • CeNAT San José, Costa Rica Enero 2020 • dataPretoria20 • University of Pretoria South Africa Julio 2020 • dataTrieste20 • alumni meeting Online Enero 2021 • dataPretoria21 • University of Pretoria Online Septiembre 2021 • dataTrieste21 • ICTP, Trieste Online Mayo 2022 • dataPretoriaSaoPaulo22 • Pretoria and Sao Paulo Online Julio 2022 • dataTrieste22 • ICTP Trieste, Italy •


The Heliocentric Model of Open Science Documentation Understanding Scientific Information Stewardship Top-Down and Bottom-Up v6 29NOV2024 Monica Gonzalez-Marquez, et al*, Open Science Advocate mg246@cornell.edu DOI: 10.5281/zenodo.14242541 1. Do away with a paper-centric model of documentation 2. Return to first principles and allow Scientific Questions and their constraints to guide documentation structure. 3. For optimal communication, allow the labor of the scientific process to determine: a. What needs to be documented b. How it should be documented Golden Rule: Documentation is for communication with humans The documentation tools we build are meant to serve the components of the scientific process, not exist independently: Data without its context is meaningless. Credit: T Šimko. METHODS METHODS *paper with collaborators forthcoming Scientific documentation should not be constrained by the limits of the out-of-date research article. Scientific information takes make shapes and model media should be used to accommodate it. The purpose of documentation is to Communicate our science to current and Future generations. Science is a verb, it is labor. RDM should be grounded in preserving Information about the labor that produced the data, as well as the data itself. Instead of allowing the paper and publishing constraints to dictate what information is documented for posterity and how, Helio positions the research question at the helm of record-keeping. It is in turn, constrained by the resources needed to ask the question. These two layers are constrained by the communicative drive: science that is not communicated in usable fashion, may as well not exist. It is also a complete waste of resources, and thus not sustainable. The methods satellite below shows some of the labor involved in completing the methods component of a human science study. These details are indispensable to understanding how to interpret and potentially reproduce a study. They are also indispensable to accurate peer review. Current documentation practices either grossly under-describe or completely omit these needed details. Helio provides needed structure to Open Science efforts by helping map tools, infrastructure and other resources directly to components of the scientific process, thus reframing them as being directly at the service of documenting complete research processes for posterity. Helio uses labor as the basic unit to breakdown scientific processes for documentation. These satellites are not mapped to sections in a paper but to components of scientific processes, as instantiations of the scientific method, and as the labor needed to complete them. This presupposes that scientific processes and their components will vary according to discipline. This model is an analogy of the original planetary model transition process. Just as it was an error to position the Earth at the center, it has been an error to place the paper at the helm of scientific documentation. It doesn’t matter how sophisticated a machine learning algorithm might be or what A.I. can do, the ultimate interpreters of scientific information will always be people. Hence, we must document so that information is usable and understandable by people. ©Inês Silva for all figures unless otherwise noted The paper is demoted to become the narrative. In this way it assumes the role it has in practice which is to function as an extended abstract with links to detailed, usable descriptions of the labor and labor products of the scientific process.


Centro Universitário Euroamericano - UNIEURO / Curso de Medicina Humanidades Médicas REDUÇÃO DE DANOS: USO DE PSICOESTIMULANTES POR ESTUDANTES DE MEDICINA 1Autores: MARIANA DIAS TEIXEIRA; NATÁLIA FERNANDES CAVALCANTI; NICOLE COSTA DE HOLANDA; VALENTINA DINIZ CATHOUD; PEDRO AUGUSTO M FERREIRA ; WESLEY RIBEIRO DE CASTRO 2 Orientadoras: VANESSA TEREZINHA ALVES TENTES; PROFª MS DIANA ARISTOTELIS ROCHA DE SÁ INTRODUÇÃO O uso de psicoestimulantes, como o metilfenidato, tem se tornado comum entre estudantes de medicina, que recorrem a esses medicamentos para melhorar o desempenho acadêmico, principalmente em situações de alta pressão. No entanto, o uso indiscriminado sem prescrição médica levanta preocupações sérias sobre os efeitos colaterais e o risco de dependência. Diante disso, a abordagem de redução de danos emerge como uma estratégia fundamental para minimizar os impactos negativos dessa prática, promovendo um uso mais seguro e informado dos medicamentos. OBJETIVO Este artigo busca discutir a aplicação de estratégias de redução de danos relacionadas ao uso de metilfenidato por estudantes de medicina, com foco em minimizar os riscos à saúde física e mental, além de fornecer suporte educacional e psicológico para esses indivíduos. MÉTODO RESULTADOS A revisão revelou que aproximadamente 23,3% dos estudantes de medicina recorrem a substâncias psicoestimulantes, como o Venvanse e o Ritalina, para superar a fadiga e melhorar o desempenho acadêmico. Notavelmente, 57,1% desses indivíduos utilizam tais medicamentos sem prescrição médica ou diagnóstico formal, obtendo-os de forma ilícita através de amigos, parentes ou receitas falsas. O uso de metilfenidato sem prescrição entre estudantes de medicina é uma questão crítica que exige intervenção imediata. As estratégias de redução de danos, quando aplicadas de forma eficaz, podem diminuir os riscos à saúde e promover o bem-estar geral dos estudantes. É essencial que as instituições de ensino médico implementem programas educacionais e de suporte que abordem as causas subjacentes ao uso desses medicamentos, proporcionando um ambiente acadêmico mais saudável e seguro. REFERÊNCIAS Lopes, J. V. et al. (2024). Metilfenidato e Venvanse: o impacto na qualidade de vida dos estudantes de Medicina. Brazilian Journal of Implantology and Health Sciences, 6(8), 1891- 1906 Amaral, N. A. et al. (2022). Precisamos falar sobre uso de Metilfenidato por estudantes de medicina - revisão da literatura. Revista Brasileira de Educação Médica, 46(2), e060 Santos, M. E. B. V. et al. (2022). Uso de metilfenidato e lisdexanfetamina por universitários da área da saúde: uma revisão bibliográfica. Revista Corpus Hippocraticum, 2(1) CONSIDERAÇÕES FINAIS Foi realizada uma revisão de literatura em bases de dados como PubMed, Scielo e LILACS, com foco em estudos sobre o uso de metilfenidato entre estudantes de medicina sem diagnóstico de TDAH (Transtorno de Déficit de Atenção e Hiperatividade). Foram analisadas pesquisas publicadas nos últimos cinco anos, que abordam tanto os efeitos do uso quanto as estratégias de mitigação dos danos associados ao uso não supervisionado de psicoestimulantes A rotina dos estudantes de medicina é marcada por alta carga de trabalho, longas horas de estudo, estágios e preparação para exames. Com isso, muitos estudantes recorrem a estimulantes como o Venvanse e a Ritalina, com a expectativa de melhorar a capacidade de concentração, aumentar a produtividade e diminuir a fadiga mental e física.Esses psicoestimulantes agem inibindo a receptação dos neurotransmissores, resultando em um aumento da concentração extracelular de dopamina e norepinefrina. Contribuindo para a melhora dos sintomas associados ao TDAH, como a desatenção, hiperatividade e impulsividadeApesar dos benefícios percebidos, a eficácia real desses medicamentos para indivíduos saudáveis, sem diagnóstico clínico, é questionada, com evidências sugerindo que o efeito placebo pode desempenhar um papel significativo na percepção de mel


www.dtls.nl • https//www.helisacademy.com/en • A three year project targeting the Life Science & Health sector • Aim: Improve skills for both new staff and existing staff (lifelong learning) on identified gaps, by developing tailored training • Helis themes identified: Good manufacturing practices (GMP), Clinical testing, Business development, Product & process design, Data Analysis & Stewardship • Contact: celia.van.gelder@dtls.nl • https://zenodo.org/communities/nl-ds-pd-ls/ • Aim: professionalise the data steward function within the life-sciences domain, with a special focus on implementation of the FAIR principles and endorsed by all stakeholders in NL • First deliverable: Life Science Data Steward Function Matrix v1.1, for 2 levels of Data Stewards and 9 knowledge areas: https://zenodo.org/record/2561723 • Upcoming: defining competences and building training • Contact: celia.van.gelder@dtls.nl FAIR Data Training and Community Building activities in the Netherlands Mateusz Kuzak, Christine Staiger and Celia W. G. van Gelder (DTL/ELIXIR-NL) Interoperability, FAIR data stewardship and training researchers and data experts are themes that are core to the remit of DTL and ELIXIR Netherlands. In line with these focal points, a significant part of our DTL Learning/ELIXIR- NL training activities can be categorized as “FAIR Data Training & Community Building”. They are set up with and by the DTL and ELIXIR-NL Community in the Netherlands, and in close collaboration with the DTL Data and DTL Technologies programmes. A number of highlights are shown here, more information can be found at https://www.dtls.nl/fair-data/fair-data-training/. Community Building – The Data Stewards Interest Group Defining the Data Steward profession & Curriculum Building • https://ds-wizard.org/ • The Data Stewardship Wizard (DSW) is a web-based application for preparing smart Data Management Plans. It connects to additional learning resources and helps raise awareness about DS challenges. It can be customised by Data Stewards or Funders to meet more specific needs. • Contact: rob.hooft@dtls.nl Training in Data Analysis & Stewardship • https://www.dtls.nl/community/interest-groups/data- stewards-interest-group/ • A community hub for Data Stewardship that enables informal and inclusive knowledge and experience exchange. • Ca. 90 members (NL, BE, LU, UK, SE, FR, DE) • Mission: • Providing a platform for Data Stewards and like-minded in the Netherlands (and abroad) to share the experience • Fostering the national implementation of Data Stewardship • Joining efforts to produce hands-on solutions • Contact: Jasmin Böhmer (chair), j.k.bohmer@umcutrecht.nl Contact Celia van Gelder Programme Manager DTL Learning/ELIXIR-NL Training, celia.van.gelder@dtls.nl Mateusz Kuzak Scientific Community Manager DTL, mateusz.kuzak@dtls.nl Christine Staiger Data Steward DTL, christine.staiger@dtls.nl The ELIXIR Data Stewardship Wizard


ABSTRACT Hepatitis E virus (HEV) is a lesser-known hepatitis virus, but its worldwide spread is doubtless and has increased recent years. Zoonotic spread of HEV, mainly due to genotype (gt) 3, has emerged in developed countries in the past decade. The current study has shown for the first time that domestic pigs in Bulgaria are widely infected with HEV. There is a need for a method for the cost-effective detection of the HEV infection and production of HEV immunogenic proteins that can be used as diagnostic antigens for the serological tests. Also, in this study we have compared the results from a commercial ELISA and an in-house ELISA test based on HEV open reading frame (ORF) 2 protein produced in planta, the sensitivity and the specify of the tests were evaluated. The development of a HEV diagnostic kit based on plant-derived ORF2 capsid protein is our goal and this will help to reduce the cost of such a kit and to enable diagnoses of HEV in developing countries. Serological diagnostics of hepatitis E virus infection in pigs based on capsid protein (ORF2 genotype 3) expressed in planta – sensitivity and specificity Katerina Takova 1, Tsvetoslav Koynarski 2, Valentina Toneva 1, 3, Gergana Zahmanova 1, 4 Acknowledgements In total, 433 swine blood samples were collected from 19 different pig farms and 1 slaughterhouse, located in eleven districts across Bulgaria—Pazardzhik, Plovdiv, Stara Zagora, Yambol, Ruse, Razgrad, Silistra, Shumen, Varna, Dobrich, and Burgas district. The samples were collected during 2017 (n = 75), 2018 (n = 158), and 2019 (n = 200). In 2018 samples were taken from two age-groups, 6- month-old pigs that weighed around 80–100 kg (n = 78), and approximately 3- month-old pigs that weighed around 30 kg (n = 80). The samples taken in 2017 and 2019 are all from 6-month-old pigs. In addition, 32 meat chunks from wild boar were collected for meat juice extraction. The samples were collected from animals hunted in Stara Zagora, Vratsa, Montana, and Dobrich districts during the official hunting season. CONCLUSION: This study confirmed that plant-derived HEV diagnostic antigen could provide a cost-effective and scalable alternative of the commercially available coating protein. This research was funded by the Research Fund at the University of Plovdiv, competition “Young Scientists and Doctoral Students” MU21-BF-02, the Bulgarian National Fund, Project DNTC/Russia 02-6, Project PlantaSYST. PlantaSYST has received funding from the European Union’s Horizon 2020 research and innovation programme (SGA-CSA No 664621 and No 739582 under FPA No. 664620) Figure 1. The map of Bulgaria represents the districts of origin of the farming pigs tested in grey - Pazardzhik, Plovdiv, Stara Zagora, Yambol, Ruse, Razgrad, Silistra, Shumen, Varna, Dobrich, and Burgas district. The origins of the wild boar’s testes are marked with red circles. Wild boar samples originated from Stara Zagora, Dobrich, Vratsa and Montana district. Figure 4. Determination of the optimal antigen concentration (recombinant capsid protein) for the developed ELISA. A two-fold dilution series of the recombinant capsid protein was performed to identify the optimum working concentration, and a titration experiment was performed using pig sera already with known serostatus. Results of the checkerboard titration analysis demonstrated that the most optimal and reliable results were obtained with coating protein concentration of 2 ng/ul. Figure 2. A A high HEV seroprevalence at all farms in 2019 – [98% (95% Cl 96.4 to 99.9)] compared to 2017 – [45.33% (95% CI 2.7 to 87.3)] and 2018 – [38.46% (95% CI 29.1 to 49.7) is observed. A significant year effect (2019) was found, p-value < 0.01 (Table 2). The chi-square statistic is 149.0211. The p-value is < 0.00001. The result is significant at p < 0.01. B Distribution of the observed within the farm seroprevalence of HEV among the slaughter-aged pigs (17 farms and 1 slaughterhouse with 30 % 2017- 2020, Bulgaria). The chart r


Potential Cost-saving for Liquid-to-Solid Medicines among Paediatric Patients Wei Chern Ang1,2, Mohamad Syafuan Fadzil2*, Chian Khie Lim2, Nur Inani Mohamad Nasir2, Muhammad Asyraf Amir2 1 Clinical Research Centre, Hospital Tuanku Fauziah, Ministry of Health Malaysia 2 Department of Pharmacy, Hospital Tuanku Fauziah, Ministry of Health Malaysia BR-08 NMRR-18-2790-44206 Introduction The World Health Organisation (WHO) recommends that children be treated with oral solid medicines for drugs, especially those require a precise dose titration.1 Problem statement: Factors that can affect a child’s success in swallowing pills include developmental stage, fear, anxiety, intolerance of unpleasant flavors and failure to appreciate the risks associated with the non- compliance. Inadequate dosing flexibility without the need of tablet crushing explained the lack of usage of solid oral formulation in pediatrics.2 The current practices only based on preference of prescribers and patient’s parent/care. Justification of Study: •There are still lack of evidence regarding the solid oral formulation suitability in Malaysia • There is no published study in Malaysia that analyses the cost differences when oral liquid medications were changed to oral solid medications in a hospital outpatient setting. Objective: 1. To examine the association of demographic and solid dosage suitability. 2. To investigate factors affecting prescribing of solid oral dosage dorms. 3. To examine the potential cost savings if patient were prescribed with solid over liquid preparations. Methods This cross-sectional study conducted from October 2018 to March 2019 among patients visiting Paediatric Clinic, Hospital Tuanku Fauziah (HTF), Kangar, Malaysia. Discussions/Conclusions 1. WHO (2008). Report of the informal expert meeting on dosage forms of medicines for children. Geneva, Switzerland.15-6. 2. Patel A et al. (2014). J Pediatr. 135;183 3. EMA (2011) Guideline on Pharmaceutical Dev. of Medicines for Paediatric Use. 4. Lajoinie A et al. (2014). Br J Clin Pharmacol. 78(5); 1080-1089. 5. Jacobsen, L et al.(2016) Tablet/capsule size variation among the most commonly prescribed medication for children in the USA; 65-73. Variable Solid Dosage Suitability p-value Yes No Age (years) 2-5 6-11 >12 Weight (kg, adjusted by age) <13 >13.01 Race Malay Non-Malay Disease condition Acute Chronic Gender Male Female 107 (47.6) 50 (42.0) 10 (37.0) 97 (50.8) 70 (38.9) 162 (45) 5 (45.5) 153 (46.8) 14 (31.8) 96 (46.8) 71 (42.8) 118 (52.4) 69 (58.0) 17 (63.0) 94 (49.2) 110 (61.1) 198 (55) 6 (54.5) 174 (53.2) 30 (68.2) 109 (53.2) 95 (57.2) 0.425* 0.021* 0.976** 0.075** 0.463** References Variable Crude OR (95%CI) p-value Age (years) 2-5 6-11 >12 Weight (kg) Disease condition Acute Chronic Gender Male Female 1.00(ref.) 1.25(0.80,1.96) 1.54(0.67,3.51) 1.04 (1.01,1.07) 1.00 (ref.) 0.53 (0.27,1.04) 1.00 (ref.) 1.18(0.78, 1.78) 0.327 0.303 0.004 0.064 0.435 In conclusion, conversion of liquid to suitable oral solid medications is cost-saving and feasible to be practised. • Most tablets prescribed were in the range of 5-10mm (62.5%) which are only suitable for 6-11 years old.3 However, there is no significance difference between age group and solid dosage suitability (p>0.05). • Most of prescribed medication for paediatrics varied widely in size e.g. paracetamol 500mg tablets ranged from 5 to 22mm, with a median of 15mm. The common paediatric antibiotics were larger with a median diameter of 17mm).5 • Most of our paediatric patients were 2-5 years old (60.6%). However, only a fraction (15.1%) of tablet with size of 3-5mm were only suitable for this age group. Liquid formulation will still be suitable for this group of patients. In our setting, parents/carers may still be afraid for patients to take solid dosage medication in this age. • Suitability of oral solid dosage forms based on size from the EMA3 may not be suitable for Asian population. To the best of our knowledge, there is no consensus or g