The goal § Accessible (and inclusive) availability of the three runic inscriptions and their metadata according to the FAIR principles 1. The state of the art § Damaged writing support § Progressive difficulty in reading the inscriptions § No ontological description of the texts and of the metadata available to date 3. The Method § Texts: TEI- EpiDoc XML (v. 9.5) and CRMtex (2.0 model) § Metadata: CRMtex (2.0 model) 4. Example: the inscription on the right shoulder vRunic texts: TEI-EpiDoc XML (v. 9.5) vMetadata: CRMtex (2.0 model) 5. Next Steps ØRTI-Dome ØLemmatization ØLinking ontological description to the 3D model Runes in Venice. Ontological description of the runic inscriptions on the Piraeus Lion (Venetian Arsenal) Paola Peratello Università Ca’ Foscari Venezia paola.peratello@unive.it DH Benelux 2024, Leuven: Breaking Silos, Connecting Data: Advancing Integration and Collaboration in Digital Humanities <div type="textpart" subtype="fragment" n="1"> <ab> <lb n="1"/>ᛅ<unclear>ᛍᛘ</unclear>ᚢᚾ<unclear>ᛐ</unclear>ᚱ᛭ᚱᛁ<unclear>ᛍᛐ</unclear>ᛁ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="1" unit="char"></gap><unclear>ᚾ</unclear>ᚱᚦᛁᛍᛅᚱ᛭ᚦᛅᛁᚱ᛭ᛁᛍ<unclear>ᚴ</unclear> <lb n="2"/><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚦ<unclear>ᚢ</unclear>ᚱᛚᛁᚠ<unclear>ᚱ</unclear><gap reason="lost" quantity="4" unit="char"></gap>ᛅᚢᚴ᛭<gap reason="lost" quantity="1" unit="char"></gap>ᚢ/ᚱ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="1" unit="char"></gap>ᚬ<gap reason="lost" quantity="1" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="5" unit="char"></gap><unclear>ᛐ</unclear><gap reason="lost" quantity="1" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage> <lb n="3"/><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚢᚠᚱᚢ<unclear>ᚴ</unclear><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚱ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><unclear>ᛋ</unclear><gap reason="lost" quantity="2" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="2" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚢᛅᚾᚠ<unclear>ᛅᚱᚾ</unclear>᛭ </ab> </div> TEI/EpiDoc XML Photos by Paola Peratello, 2023, on concession of the Comune di Venezia and of the Arsenale di Venezia. 1. Nᛍᛘunᛐᚱ᛭ᚱᛁᛍᛐᛁ…-nᚱᚦᛁᛍNᚱ᛭ᚦNᛁᚱ᛭ᛁᛍᚴ 2. …ᚦuᚱᛚᛁᚠᚱ----Nuᚴ᛭-u/ᚱ…-ᚬ-…-----ᛐ-… 3. …uᚠᚱuᚴ…ᚱ…ᛋ--…--…uNnᚠNᚱn᛭ Check the bibliography here Transrunification from Snædal 2016 Ontological description according to CIDOC-CRM and CRMtext Check the project here


Figure 8. Crystal structure of both a type II inhibitor, ima7nib, and a type IV inhbitor, GNF-‐2, bound to the kinase domain of c-‐ Abl (3K5V.pdb). GNF-‐2 is a fully allosteric inhibitor of WT Abl and rescues type I/II inhibitor eﬃcacy against T315I both in vitro and in vivo. Gly250 Tyr253 Glu255 Met351 Phe359 Thr315 In addi7on to playing an essen7al role in cellular energe7cs, kinases and their associated signaling pathways regulate a plethora of intracellular processes. When aberrantly expressed or controlled, kinases can cause cellular dysregula7on and contribute to the onset of several diseases, including cancer. Based on the fundamental understanding of kinase dysregula7on in cancer biology, the discovery of small organic molecules to alter kinase func7on has culminated in the development of targeted cancer therapy. However, limited selec7vity and the emergence of drug resistance remain fundamental challenges for current modern medicinal chemistry eﬀorts aimed at the development of kinase inhibitors that are both safe and eﬀec7ve as long-‐term treatments. Muta7ons resistant to classical ATP-‐compe77ve (Type I/II) kinase inhibitors emerged at a rapid pace and oTen limit the success of newly available targeted cancer therapies. At present, there are more than 70 individual muta7ons at more than 50 muta7on sites conferring diﬀerent levels of ima7nib resistance found within CML pa7ents. Recently, a number of Type IV kinase inhibitors that func7on via a fully allosteric mechanism of ac7on have demonstrated promise toward addressing muta7on dependent drug resistance. BINDING STUDIES OF TYPE I, II, AND IV KINASE INHIBITORS AGAINST ABL KINASE USING BACK-‐SCATTERING INTERFEROMETRY MOA FOR ALLOSTERIC INHIBITORS THAT OVERCOME DRUG RESISTANCE Fei Shen, Nathaniel Gilbert, Robert R. Lavieri, Richard J. Isaacs, Scot R. Weinberger Molecular Sensing, Inc. Back-‐scaNering Interferometry The Back-‐scaYering device is a micro-‐scale interferometer (see ﬁgure 4). The BSI device consists of a HeNe laser, a microchip, and a CCD camera. The microchip receives light from the laser and illuminates the sample containing channel. As light passes into the channel, interference fringe paYerns arise and a camera images the fringes (Figure 4). When molecules bind, the resultant complex causes a change in molecular mean polarizability that is measured as a fringe paYern shiT. Monitoring the change in fringe phase as a func7on of ligand concentra7on allows equilibrium dissocia7on constant (Kd) measurements to be performed. SeRng up the BSI assay BSI Kd determina7ons are performed in end-‐point fashion, with target and ligand pre-‐incubated to establish equilibrium. Target and ligand concentra7ons are chosen to ini7ate pseudo-‐ﬁrst order binding condi7ons, for which the target is typically held at a sparing concentra7on and the ligand is present in excess to avoid ligand deple7on during the binding process. Back-‐scaNering Interferometry Kinase inhibitor binding analysis and BSI data validaTon References Materials and Methods www.molsense.com Sample Reference Figure 11. Prepara7on of kinase Inhibitors. Ima7nib, dasa7nib, nilo7nib and GNF-‐5 were prepared as 50 mM working stocks in 100% DMSO. Dose response series were created by dilu7ng each working stock with MOPS buﬀer to establish the appropriate target concentra7on range for each binding system using a 12-‐point doubling dilu7on (range: 50 pM – 125 μM). DasaTnib (nM) NiloTnib (nM) ImaTnib (nM) c-‐Abl Kinase IC50 KD IC50 KD IC50 KD Wild-‐type 1.83 1.08 17.69 13.3 527 472 M351T 1.61 0.42 7.8 2.7 926 1086 Q252H 5.6 5.49 46.7 47.6 733 961 H396P 1.95 0.7 42.6 32.6 1280 1228 T315I 137 86.5 696 761 9221 4050 Figure 9. 9A. The Kd of ATP for both WT and T315I Abl is about 4-‐5 micromolar. 9B. The Kd values for GNF-‐5 vs. WT and T315I Abl are about 510 nM and 130 nM respec7vely. 9C. Interes7ngly, in the presence of a satura7ng amount of GNF-‐5 (50 μM) the binding curve for ATP is right-‐shiTe


SUBUrB Software zur Unterstützung von Bibliotheken bei urheberrechtlichen Bewertungen • Problem: Bestandslücken bei Bibliotheken • Fehlende Bücher müssen beschafft werden • Prüfung des Urheberrechts • Gemeinfreie Bücher können ausgeliehen und kopiert werden • Geschützte Bücher müssen (wenn verfügbar) gekauft werden • Prüfungen sehr aufwendig • Bisher manuell erledigt Literatursoftware SUBUrB • Prüfungen lassen sich automatisieren • Urheberrecht folgt klaren Regeln • Autoren seit über 70 Jahren tot: Werk gemeinfrei • Sonst: Werk geschützt • Software recherchiert Todesdaten • Beurteilung je nach Informationsstand Idee • Nutzer können Bücherlisten anlegen • Software sucht nach Daten in Katalogen • Deutsche Nationalbibliothek • Landesbibliotheken • … • Ergänzung fehlender Daten • Urheberrechtliche Beurteilung wird erstellt • Triviale Fälle können auch bei fehlenden Daten abgehandelt werden • Buch älter als 180 Jahre • Buch jünger als 70 Jahre • Ergebnisse werden übersichtlich dargestellt Funktionsumfang • Implementierung eines Prototypen • Vorstellung der Idee+Prototyp auf dem IRIS 2015 • 2. Platz beim Best Paper Award Aktueller Stand • Kooperation mit der Europäischen EDV-Akademie des Rechts (EEAR) • Suche nach Partnern (Bibliotheken) • Anpassung an Bedürfnisse der (späteren) Kunden • Erweiterungen für Digitalisierungsprojekte • Verwaiste und vergriffene Werke Entwicklung juris-Stiftungsprofessur für Rechtsinformatik Prof. Dr.-Ing. Christoph Sorge Cand. iur. Stefan Hessel Frederik Möllers, M.Sc. Übersicht über verwaltete Bücher (Screenshot des Prototypen). Verwaltung einzelner Werke (Screenshot des Prototypen). Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz.


Draft Simulation studies for the ATLAS track-counting luminosity measurement Giulia Ripellino on behalf of the ATLAS Collaboration Abstract A precise measurement of the luminosity is a key component of the ATLAS physics programme. ATLAS uses several detectors and algorithms to determine the luminosity. The absolute calibration of these algorithms is carried out in LHC runs with special beam conditions at low luminosity. The track-counting luminosity measurement is used to determine the calibration transfer from the low-luminosity regime to the high-luminosity conditions typical of standard physics data taking, and to monitor the long term stability of the default luminosity method. The track-counting method works by counting the number of reconstructed tracks from charged particles inside the Inner Detector. The average number of charged particles in randomly-triggered events is proportional to the average number of inelastic collisions per event and can therefore be used to compute the luminosity. This poster presents simulation studies for the ATLAS track-counting luminosity measurement. A toy simulation model is used to study the underlying distribution of the number of tracks and to illustrate the linearity between the average number of tracks and the luminosity. Full ATLAS MC simulation is used to assess effects related to the reconstruction of the tracks and their effect on the linearity. Method The LHC bunch luminosity is given by Lb = µfr σinel (1) where µ is the average number of inelastic pp collisions per event, fr the LHC revolution fre- quency, and σinel the pp inelastic cross-section. • The track-counting measurement uses the av- erage number of charged tracks of randomly triggered events to measure the luminosity. • The visible interaction rate is given by µvis = ⟨Ntracks⟩= Nevents P i=1 N i tracks Nevents ∝µ. (2) • Two different track selections are explored Selection |η| N Pixel Holes |d0/σd0| pT 2016 < 2.5 0 < 7 > 0.9 GeV 2017 < 1.0 ≤1 Track selections for the track-counting measurement, based on the TightPrimary selection defined in Ref. [1]. Track-multiplicity pdf in MC Normalized track distributions in a Pythia8 A3 minimum bias MC sample with exactly one pp interaction per event. The distributions can be interpreted as the track-multiplicity probability density functions (pdfs) for each track selection. Linearity in toy simulation The linearity between µvis and µ illus- trated in a toy simulation model. For each event, the number of interactions is determined from a Poisson distribution with mean µ. The number of tracks per interaction is then sam- pled from the track-multiplicity pdf. The result- ing track distribution is used to determine the mean number of tracks per event for the spe- cific value of µ. The proportionality constant between µvis and µ corresponds to the mean of the track-multiplicity pdf. Linearity in full simulation Relation between µvis and µ in full simula- tion. A Z →µµ MC sample with overlaid mini- mum bias events as pileup is used for the study. Tracks from the hard scatter interaction are ex- cluded in the number of reconstructed tracks. The µ-dependence is parameterised by a first- order polynomial, fitted in the range µ<40. The non-linearity results from the effects of track reconstruction efficiency and fake tracks. The higher non-linearity in the 2017 selection is likely due to the looser track-selection requirements. Track-multiplicity pdf in data The 2017 track selection MC pdf is compared to data in order to assess the modelling of the track multiplicity. The data track-multiplicity pdf is derived from the distribution of the number of tracks per event in data with ⟨µ⟩≪1 (left), selected for the purpose of eliminating events with more than one pp interaction. Events with zero tracks can arise either from bunch crossings where no pp interaction occurred (“empty crossings”), or from bunch crossings with one pp interaction in which no track satisfied the track-selection criter


NF Research Tools Database: An experimental resource database for the neurofibromatosis community 1 Sage Bionetworks , Seattle, WA, USA 2 Gilbert Family Foundation, Detroit, MI, USA Correspondence: nf-osi@sagebionetworks.org Brynn Zalmanek, MLIS1, Robert Allaway, PhD1, James Goss, PhD2, Ashley Clayton, MS1, James Eddy, PhD1, Kaitlin Throgmorton, MLIS1, Jineta Banerjee, PhD1, Kalyan Vinnakota, PhD2, Caroline Morin, BS2, YooRi Kim, MS2, Justin Guinney, PhD1 Approach Highlights ●We are developing a centralized resource database for NF1 research tools, including animal models, cell lines, antibodies, genetic reagents, and biobanks. ●The research community will be able to contribute feedback, usage notes, and other observations about these tools to the database. ●We are recruiting testers to participate in an upcoming evaluative design study to ensure that this resource is useful for the research community. Background & Introduction ●When the Gilbert Family Foundation (GFF) started to fund investigators with little or no prior experience in NF1 research, it became evident that research progress was impacted by the challenge of identifying, evaluating, obtaining, and/or creating the tools required for their research. ●While a variety of databases exist for investigators to find useful research tools these databases are usually: ○Specific to the type of resource, ○Too broad in scope, and/or ○Do not include newly developed or unpublished models ●To accelerate NF research, we are building the NF Research Tools Database, a database and companion web application to store and explore information about model resources specifically relevant to the NF community. ●The database will include key attributes for each resource and contributed observational data from publications and the research community. ●The database development consists of three phases (Figure 1): ○Design (current phase): Generation of a prototype database website. ○Pilot: Visitors can search and explore the contents of the database through the website. ○Long-term Development: Members of the NF community will be able to submit resource attributes or observations through a user friendly submission process. Acknowledgements The project team would like to thank Ljubomir Bradic, Stockard Simon, Bruce Hoff, Jay Hodgson, Kevin Boske, and Ryan Luce for helpful discussions regarding the design and development of this application. Icons made by Eucalyp from www.flaticon.com. This work is supported by the Gilbert Family Foundation. Conclusions & Future Directions ●GFF and Sage Bionetworks have made significant progress in developing a prototype tools database and companion web application for NF1 research resources. This resource could be a one-stop-shop for learning about the various experimental tools that have been generated by the NF1 research community ●After the prototype phase, we plan to expand the scope of this database to include NF2 and schwannomatosis-related resources ●We encourage feedback from the research community, particularly: ○What NF1-relevant animal models, cell lines, antibodies, genetic reagents, and biobanks you would like to see listed in the database. ○What types of research resource attributes you consider when, for example, selecting a cell line for an experiment. ○Whether you would be likely to contribute observational information about a research resource to a database like this. ●We are recruiting testers to participate in an upcoming evaluative design study. Please contact nf-osi@sagebionetworks.org if you are interested in participating in this study (Q4 2021) or contributing information about an NF1 research resource! Evaluating External Data Sources & Prior Work Designing a Data Model Identifying Use-Cases Prototype Design & Evaluation ●GFF developed an alpha version of the database, incorporating tools utilized within GFF research programs and soliciting feedback from their awardees on how to best classify and characterize each tool. ●Sage then condu


In Situ Origins of Hot Jupiter Isolation Brandon Radzom1, Songhu Wang1, Bonan Pu2 1Indiana University, 2Cornell University • Outstanding issue: Hot Jupiters are more observed to be more isolated than warm Jupiters • Context: • Widespread prevalence of super-Earths in compact multiple-planet systems • Super-Earth pairs packed near the boundary of Hill instability (Pu & Wu 2015) • Most exhibit “peas in a pod” structure (Weiss et al. 2018) • Many are sufficiently massive to trigger runaway accretion (Lee et al. 2014; Batygin et al. 2016) • Our work: Use N-body simulations of mass-boosted super-Earths to demonstrate that in situ formation naturally produces observationally isolated hot Jupiters and warm Jupiters with nearby low-mass companions Introduction N-body Simulation Set-up References: Batygin, K., Bodenheimer, P. H., & Laughlin, G. P. 2016, ApJ, 829, 114; Lee, E. J., Chiang, E., & Ormel, C. W. 2014, ApJ, 797, 95; Millholland, S. C., He, M. Y., & Zink, J. K. 2022, arXiv e-prints, arXiv:2207.10068.; Pu, B., & Wu, Y. 2015, ApJ, 807, 44; Weiss, L. M., Marcy, G.W., Petigura, E. A., et al. 2018, AJ, 155, 48, Main Results Our final systems exhibit three key properties (Figure 1): 1. Hot Jupiter Isolation. Period ratios of our hottest Jupiters (𝑃< 5 days) relative to their nearest companions are typically larger than those of warm Jupiters (by a factor of ~2). Thus, a large fraction of hot Jupiters' companions would not yet be detectable through transit timing variations or transit searches. 2. Dynamical Sweet Spot. Inner companions rarely survive for the hottest Jupiters but are seldom destroyed for hot Jupiters in the dynamical “sweet spot” (5 < 𝑃< 7 days). This sweet spot marks a dramatic drop in the average period ratio and a transition to inner companion configurations. 3. Mirrored Architectures. Our hot and warm Jupiter systems mirror each other— inner companion period ratios steadily increase with giant period while outer ratios tend to decrease. Step 1: Generate Stable Peas-in-a-Pod Systems We generate 200 peas-in-a pod systems, each with eight super-Earths orbiting a solar mass star. We then boost the mass of one planet per system to 1 Jupiter mass (MJ), driving instability, and integrate to 𝑡= 10 Myr. Step 2: Provide Mass Boost Dynamics: The giant’s position chiefly determines the final configuration since companion-companion collisions dominate (Figure 2). Hot Jupiter Isolation Dynamical Sweet Spot Mirrored Architectures Figure 2. Fraction of companions that avoid collisions & ejections (black squares; left axes) and average timescale for such events (blue shading; right axes) as a function of planet position, stacked for each giant’s position. Giant positions are shown schematically at the top of each panel (large black circles). Figure 1. Final giant period ratios with their nearest neighbor as a function of giant period, with orientations indicated (red rightward and blue leftward triangles). The mirror effect between our red and blue triangles may be astrophysical so long as peas-in-a-pod systems become truncated (see Millholland et al. 2022). A long planet chain exists outside the hot Jupiter, resulting in collisional cascade once two adjacent planets reach 𝑒≈𝑒𝑐/2. The hot Jupiter also merges with its nearest inner companion, leaving it isolated. The hot Jupiter has two inner companions which quickly merge and are then Hill stable for all time, since the Jupiter will “filter” 𝑒excitation. The number of companions on either side of the giant dictates the system’s fate, causing a mirrored effect for hot and warm Jupiter configurations. Sweet spot Innermost period @ 3-day pile- up Orbital eccentricities are bound by orbit-crossing value 𝑒𝑐 25 simulations run for each planet boosting position (25 × 8 = 200) Spacing based on the Equal Mutual Separation scheme— pairs initially Hill stable but pushed near 𝐾= 3.5 threshold after mass-boosting 𝑃~6 d 𝑃~4 d 𝑃~30 d


sdfsafdsa Using digital tools and methods for a systematic literature review Representing social media interactions and meanings as knowledge graphs Creating a curation-enabled social media research archive The Connective project A three-year EU-funded research project (2020-2023) aiming to: Reveal how memory practices on social network sites inside and outside Lithuania, mediated by contested heritage, enable the construction of multiple collective identities. Advance digital curation approaches to social media data and its future preservation and access for research. 2. Based on the ontology, we established a property graph schema using the Cypher query language to design and implement a Neo4j database of social media conversations on Lithuanian heritage, memory and identity. We adopted Open Archives Information System (OAIS) definitions of Submission, Archival, and Dissemination Information Packages, to ensure integrity and authenticity of research data collected from social media platforms, while also ensuring their intelligibility in the research process. Digital resources, methods and tools in the research lifecycle The Connective Digital Memory in the Borderlands project We used the Publish or Perish reference collection software to conduct 20 faceted queries on Google Scholar, based on combinations of Boolean query expressions for difficult heritage and social media platforms. The queries yielded 1,201 documents. Costis Dallas, Ingrida Kelpšienė, Rimvydas Laužikas Connective Research Group, Faculty of Communication, Vilnius University This poster reports on research conducted as part of “Connective digital memory in borderlands: a mixed-methods study of cultural identity, heritage communication and digital curation on social networks”. The Connective project was funded by the European Social Fund under grant agreement 09.3.3-LMT-K-712-17-0027 with the Research Council of Lithuania (LMT-LT). 11 researchers 9 themes 72 topics 4 languages 25,455 Facebook threads 264,954 messages 93,551 users 75 interviews Investigating the semiotic circulation of agency through knowledge graphs Extending nexus theory to show how attitudes on Soviet heritage move across social media, users and references to the dissonant past Investigating propagation across Neo4j person and message nodes Analyzing digital memories and perceptions of the past through qualitative content analysis Examining how Lithuanian everyday life and culture during the 1990s is represented on social media through identifications and memes Using MaxQDA and Neo4j for content and critical discourse analysis Comparing discourse constructs in actual and ChatGPT-produced social media content Investigating the use of ChatGPT to analyze and produce speculative SNS conversations on Lithuanian contested heritage Kelpšienė, Ingrida, Donata Armakauskaitė, Viktor Denisenko, Kęstas Kirtiklis, Rimvydas Laužikas, Renata Stonytė, Lina Murinienė, and Costis Dallas. 2023. ‘Difficult Heritage on Social Network Sites: An Integrative Review’. New Media & Society 25 (11): 3137–64. https://doi.org/10.1177/14614448221122186. Kirtiklis, Kęstas, Rimvydas Laužikas, Ingrida Kelpšienė, and Costis Dallas. 2023. ‘An Ontology of Semiotic Activity and Epistemic Figuration of Heritage, Memory and Identity Practices on Social Network Sites’. SAGE Open 13 (3): 1–25. https://doi.org/10.1177/21582440231187367. Laužikas, Rimvydas, and Costis Dallas. 2024. ‘The Message Is the Agent: Nexus and Semiosphere in Social Media Communication’. In Semiotics and Visual Communication IV: Myths of Today, edited by Evripides Zantides and Sonia Andreou. Cambridge: Cambridge Scholars Publishing. Publications https://doi.org/10.5281/zenodo.10886535 Entities Relationships Deposit Thread Message Agent Topic PART_OF SHARED_FROM RESPONDED_TO FOLLOWED_BY REACTED_TO POSTED DISPLAYS CONNECTED_AS IN_CONTEXT REFERS_TO 1. We built a theory-laden CIDOC CRM-compatible ontology to represent how social media users belonging


An Analysis of Disabled Accessibility Transportation in the City of Chicago Manuel Luna Jr, Industrial Design, University of Illinois Chicago Dr. Joseph Hoereth, UIC — Institute for Policy & Civic Engagement (IPCE) According to the Regional Transportation Authority (RTA), all CTA and Pace buses are 100 percent accessible (RTA, 2023). The Americans with Disabilities Act holds these transportation systems to provide accessible features such as wheelchair securement areas, ramps, priority seating, and visual displays. In reality, 76% of stations are actually functional. The city of Chicago is constantly expanding their stations, not focusing this effort on the already established stations. Funding is going towards new station projects when some of the funding should be used for fixing the old stations that need it. Chicago Accessibility Compliance Program (CACP): The CACP focuses on ensuring that public spaces, transportation systems, and municipal buildings comply with accessibility standards outlined in the Americans with Disabilities Act (ADA). This initiative involves conducting audits, implementing necessary renovations, and providing resources to enhance accessibility for individuals with disabilities throughout the city. Chicago Business Leadership Network (CBLN): The CBLN collaborates with local businesses to promote inclusive hiring practices and provide support to employees with disabilities. Through education, training, and advocacy, the CBLN aims to increase workforce diversity and create employment opportunities for individuals with disabilities. Home Accessibility Program: This program provides financial assistance and incentives to property owners for retrofitting existing housing units to meet accessibility standards. By offering grants and resources, the city encourages the creation of accessible living environments for individuals with disabilities, thereby enhancing housing options and accommodation. These policies and initiatives reflect the City of Chicago's commitment to promoting inclusivity, accessibility, and empowerment for individuals with disabilities. By addressing various aspects such as infrastructure, employment, housing, and community support, Chicago strives to create a more inclusive and equitable environment for all its residents. BACKGROUND POLICY INITATIVES RECOMMENDATIONS RESEARCH OBJECTIVE METHODOLOGY FINDINGS • Increased funding for advocacy efforts from disability rights groups would significantly enhance their capacity to promote accessibility and inclusivity for individuals with disabilities. This funding could support initiatives such as grassroots organizing, public awareness campaigns, legal advocacy, and lobbying efforts aimed at influencing policymakers and stakeholders. • Implementing and upholding inclusive design standards and infrastructure would greatly bolster advocacy efforts for accessibility from disability rights groups. By ensuring that public spaces, buildings, transportation systems, and digital platforms are universally accessible, these standards not only remove physical barriers but also validate the rights and dignity of individuals with disabilities. This research seeks to examine the way the City of Chicago addresses issues of accessibility when it comes to people with disabilities and means of transportation. By analyzing existing policies, infrastructure improvements, and community engagement initiatives, this study aims to shed light on the effectiveness of current strategies in enhancing mobility and inclusivity for individuals with disabilities within the city's transportation network. Additionally, it seeks to identify potential areas for improvement and recommendations for fostering a more accessible and equitable transportation system for all residents of Chicago, regardless of ability. Introduction: The rights and well-being of individuals with disabilities have increasingly gained attention in policy circles and societal discourse. In urban environments


www.postersession.com g Remote sensing has been used in many environmental studies because of its capacity to provide information rapidly on large and hard-to-reach areas. Recently, many programmes such as ASTER, Landsat and Copernicus Sentinels have provided satellite imagery of both high temporal and spatial resolutions free of charge. These data, combined with fieldworks and geophysical measurement , can lead to the finding of solutions for modern challenges such as climate change, natural hazards and increasing population growth. We used these technologies in a region which is both sensitive to and vulnerable to these phenomena, the karst environment of the Tabular Middle Atlas (TMA) of Morocco, in order to study the vulnerability of its natural water reserves . The TMA of Morocco contains an important water reservoir, located in Liassic carbonate rocks (dolomite and limestone), and used for everyday activities in cities such as Agourai, Fez, El Hajeb, Ifrane and Meknes. Because of its importance and the value it holds in the economy of the region it has been described as château d’eau. The most recent studies conducted in this region show that water quality is deteriorating due to anthropologic activities and natural processes. The present study proposes the use of earth observation, geophysical methods and free available data to map various forms of karst (avens, dolines, poljes...) and fault systems; these are the most fragile hotspots where the water reservoir can be easily penetrated in this karst system, with pollutants infiltrating and reaching groundwater and eventually identify most vulnerable areas. We intend to answer the question related to the part played by each fracture system, in order to find out which one is responsible for the infiltration of surface water and consequently is contributing to the development of sinkholes, and also to find out which system is draining water from the Causse to the basin. The aim of this study is to enhance the understanding of the hydrogeological system of the TMA, to improve the fracture database, to explore the profitability of new methodology combining space technology, applied geophysics and ground-based field work, and to establish a complete picture of vulnerable areas where sinkholes and human activities are degrading the quality of groundwater. There are three priority questions to be answered: -What is the direction of the fault systems involved in water infiltration, and probably led to the development of different karst landforms? -What is the predominant location of the sinkholes responsible for the turbidity and chemicals observed in water springs? -Where are water-soluble substances such as fertilizers, pesticides and herbicides accelerating carbonate dissolution due to human activities? Methods and materials Conclusions A.Muzirafuti1, M. Boualoul 1, G.Randazzo 2 , A. Allaoui1, S. Lanza 2, H. El Ouardi3, H. Habibi3, H. Ouhaddach3 1 Team of applied geophysics, Nat Ress. and Heritage, Dept. of Geology, Fac. of Sciences, University of Moualy Ismail, BP. 11201 Zitoune, Meknes, Morocco 2 Section of Earth Sciences, Dept. of Math and Computer Science, Physical Sciences and Earth Sciences, Univ. of Messina. Via F. Stagno d'Alcontres, 31 98166 - Sant'Agata di Messina, Messina, Italy – 3 Team of tec mapping, Dept. of Geology, Fac. of Sciences, University of Moualy Ismail, BP. 11201 Zitoune, Meknes, Morocco - Synthetic map of various karst landform location Fieldworks conducted in numerous locations around major faults, water springs and on different karst landforms helped us validate remote sensing results. We noticed that a big number of sinkholes are located in fractured carbonate rocks in low laying areas, some of them were identified in agricultural areas filled with basalts or clay sediments. Structural study conducted on carbonate fractures revealed that 37 % represent NE-SW fault system while 22% and 30 % represent Sub-meridian and NW-SE Fault faults systems resp


SST CCI Phase-II Requirements for Sea Surface Temperature data sets for Climate Research and Services Nick Rayner, Met Office Hadley Centre, UK SST information is needed by almost all applications in climate research and by many climate service activities. The needs of these diverse fields are varied and can seem confusing without undertaking a systematic user requirements gathering exercise. The ESA Climate Change Initiative SST project has recently reviewed requirements for climate SST data sets from a wide range of applications in climate science and services; this updates its assessment undertaken over five years ago. Responses were received from scientists in 20 countries in North and South America, Europe, Asia, Africa and Australasia. A selected, preliminary analysis of responses is presented here; the final analysis will be presented in the updated User Requirements Document (see http://www.esa-sst-cci.org/ over the coming months). On what kind of grid would you like the data? Other here included: cubed sphere; ORCA (NEMO) grid; and equal area. Please classify this application into one or more of the following applications/interests. Other here included: climate feedbacks; Combined historical, near real-time, and seasonal applications; air quality modelling; comparison with in-situ; interpretation and analysis of hydrographic data; fisheries; for assessing processes; atmospheric chemistry; analysis of relationship between SST and crop productivity and drought; responses of marine top predators to climate change; global numerical weather prediction and high-resolution numerical weather prediction; climate impact model evaluation; ocean heat content comparison; and calibration of proxy data. On what data level does the application require observations? For your application, is it more useful to have all SSTs for the same local time or the same universal time? What spatial coverage is required? What is the temporal coverage needed for your application? How quickly you need data: Is the concept of an interim climate record important to your application? Here respondents gave responses between less than one day and 30 days. SST depth. Providers of satellite SST products variously aim to report temperatures for either the radiometric skin depth they observe or for sub-suface depths. For your application, which type(s) of SST is (are) most relevant? Other included SST1m. The SST CCI project will make Level 2 and Level 3C products available in a flexible format containing information enabling users to derive the SST and its uncertainty adjusted to different depths and times appropriate to their needs. We also propose to make available a standard product file which provides information in a simpler-to-use form. This standard file would contain SSTskin at the observation time, plus one other adjusted SST If you would use this, which combination of adjustments is most relevant to your application? Other here gave no specific alternatives Is your application sensitive to locally-correlated errors (correlated within synoptic scales and uncorrelated beyond)? If SST uncertainty information were to be provided as a parametrised covariance matrix, would you use this? If SST uncertainty information were to be represented by an ensemble (a set of plausible realizations of each SST field which span the uncertainties in the data), what size of ensemble would you need for your application (how many members)? not applicable 3 to 10 10 to 50 50 to 100 100 need guidance How would you like quality/confidence information to be communicated? Other here included requests for uncertainty information or an ensemble only and not to include flags as well. What information would you like to be within the data files? Other here included: gap filled or no gap filled / how?; info on anomalously cold data; data points that may contain extreme upwelling; and information about difference w.r.t. adjacent pixels. What other ancillary data from external sources


www.rethinkaction.eu This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101037104 A platform to support local land-use decision making. Objective The main objective of RethinkAction is to engage citizens and decision-makers to participate in the energy transition and actively support climate adaptation and mitigation. Six representative case studies form the backbone of the RethinkAction project, covering the main regional differences related to climate change. Together with our End-User-Community we create an Integrated Assessment Platform. The user-friendly platform will empower citizens, stakeholders, and decision-makers to analyse climate change and incorporate climate action into the decisions that will affect our lives in the coming decades. Analysis at EU / global level Analysis at local level Land use-based Adaptation and Mitigation Solutions (LAMS) catalogue High-resolution climate data and land use maps. Climate change impacts and risks in each case study Land use-based Adaptation and Mitigation Solutions catalogued at local, EU and global scales Multiscale evaluation framework: 1) Future scenarios consistent across scales 2) Local system dynamic mo- dels for the integrated assessment of solutions 3) An upscaling function for solutions to EU and global scales (WILIAM IAM). • • • 1 Diagnosis 2 LAMS feasibility 3 Simulati on Interested? Engage! Help to make high-level information on land-use and climate change more accessible to people’s lives. Join our End-User-Community: Help to shape the direction in which RethinkAction is to be further developed. Expand and internationalise your professional network. Receive exclusive invitations to work meetings, training sessions and conferences organised by the project consortium. • • • What would happen if the LAMS assessed at local level…. …would be applied at EU / global level in all feasible locations? Upscaling solutions Simulati on with system dynamics integrated assessment model [WILIAM] An impression of the platform


1 INTRODUCTION Depuis des décennies, la Station Biologique de Roscoff suit la diversité de s communauté s planctonique s a u larg e de Roscoff, avec des prélèvements bimensuels sur les si tes "Estaca de" et "SOMLIT-Asta n" , au Nord -Es t de l 'Îl e de B atz. Plusi eurs mét hodes sont utilisées pour dénombrer les cellules , d ont la micro scopie o ptiqu e po ur les e sp èc es > 20 µm , et la cyt omé trie en fl ux p our les esp èces <20 µm*. La cy tom étrie en flu x permet de distinguer les groupes fonctionnels suivants : (i) les cyanobactéries du genre Synechococcus, (ii) les picoeucaryotes photosynthétiques, (iii) les nanoeucaryotes photosynthétiques (iv) les algues Cryptophytes (v) les bactéries et (vi) les virus marins Les données de diversité phytoplanctonique de Roscoff obtenues par microscopie optique on t déjà été bien étudiées par le laboratoire et ont m is en éviden ce u ne dynamiq ue saisonniè re t rès marquée avec des successions d’espèces au c ours de l’année (Caracciolo et al. 2022). Ce projet, focalisé sur les données obtenues par cytométrie en flux avait pour objectif : (1) d e fair e u n inventair e de s donnée s disponible s et d es protocol es utilis és po ur l es collecte r, ( 2) de détermi ner les dynamiq ues saisonniè res des principaux groupes fonctionnels distingués po ur le site SOMLIT- Ast an e t ( 3) de déter min er si les blooms saiso nni ers de Synecho coccus avaient changé de date au cours des deux dernières 20 ans de données Échantillonnage et analyse de la mer à la cellule Actuel Protocole 2 Anciens FACSCanto, FACSCan Flash frozen Sans Pluronic + Glutaraldéhyde (fixateur) + Pluronic (surfactant) Echantillonnage (Neomysis) Congélation (-20°C) Congélation (-80°C) Conservation Niskin bottle Picoeucaryotes Analyse des abondance s des group es taxonomiques Cytogramme Fluorescence Side Scatter (SSC) Synechococcus Bactéries Nanoeucaryotes + 5µl billes Polysciences fluoresbrite® Analyse (laboratoire) Microgouttelette chargée contenan t 1 seule cellule FACSort Détecteur et photomultiplicateur SSC : taille Fluorescence : naturelle ou fluorochrome Cytométrie en flux : Dynamique saisonnière au site SOMLIT-Astan 7 Trait de filet (eau de Roscoff) diatomées Synechococcus ? nanoeucaryotes photosynthétiques ? picoeucaryote photosynthétique ? © SBR 6 Cyanophage et Synechoccocus infectée © Sophie Le Panse, Plateforme MERIMAGE (SBR) 48°46'40.1"N 3°56'15.0"W 48°43'55.9"N 3°58'58.0"W 3 4 OUI Fig. 5. Variations saisonnières des abondances des 5 groupes fonctionnels sur la période d u 12/01/200 7 a u 18/12/201 9 (1 2 an s e t 1 1 mois ). Donné es issu es de la ba se PELAGO S, s ite SOMLIT-Astan surface. (d) Picoeucaryotes (e) Nanoeucaryotes (b) Bactéries (c) Cryptophytes (a) Synechococcus Pico : 0.2-2 µm Nano : 2 – 20 µm Micro : 20-200 µm *Phytoplancton → diversité de taille : 500 nm 5 8 Fig. 9. Variations saisonnières des abondances de virus HNA (2013- 2020), site SOMLIT-Astan surface. Intéractions virales Abondance virale (cellules/mL) Synechococcus est la cible de certains virus marins. Au site Astan, en surface, l'abondance des virus HNA (High Nucleic Acid content) qui ciblent Synechococcus, mais aussi des picoeucaryote s photosynthétiqu es (communicati on personnel le de AC Baudo ux) va rie de f açon saisonni ère, ave c un pi c en juin-juil let, pér iod e de développ ement des pico- et nanoeucaryotes. 500 nm 200 nm LIMITES & PERSPECTIVES → Biais potentiels dus au changement de protocole des données PELAGOS → Série temporelle courte : description possible, mais conclusions limitées → Échantillonnage tous les 15 jours insuffisant pour suivre les blooms d’organismes unicellulaires à cycle de vie court (de quelques heures à quelque s jours) De nombreuses pistes sont possibles pour explorer davantage cette communauté. Par exemple, des données de fluorescence et de PA R (Rayonnemen t Photosynthétiquemen t Actif ) son t disponible s su r l a ba se SOMLIT. Ces données pourraient révéler des changements physiologiques c hez


Resolving Surface Features on M Dwarfs that Host Transient Corotating Material Ben Tofflemire1,†, Adam Kraus1, Andrew Mann2, Greg Mace1 1The University of Texas at Austin, 2UNC Chapel Hill †51 Pegasi b Fellow RIK 12 Toy Model Complex Periodic Variables Complex periodic variables (CPVs) exhibit narrow dimming events with variable morphologies and depths that are periodic with the stellar rotation. Dimming events emerge and disappear stochastically. CPVs are predominantly young (<~200 Myr), low- mass (M<0.4 M⨀), and rapidly rotating (P<1 d). The most likely explanation for this behavior is magnetically confined material orbiting in co-rotation with the star [1,2,3]. Monitoring with IGRINS We have monitored four CPVs in Upper Sco using the IGRINS spectrograph ([4,5], simultaneous H and K at R~45,000). Here, we showcase the results for RIK 12 ([6], M2.5 SpT, 5-10 Myr, Prot = 0.49 d, G mag = 13.8, K mag = 9.7) We reconstruct the stellar absorption profiles by computing spectral-line broadening functions using the saphires package [7]. We find: • Large rotational velocities (vsini>150 km/s), consistent with edge on viewing angles • Evidence for large and evolving spot features • No significant radial-velocity variability Modeling Surface Features The cadence and baseline of our observations do not allow for a full surface reconstruction. Still, we can use a toy model to investigate characteristics of surface features that are consistent with our observations. We find the amplitude of the line-profile deviations are challenging to reproduce with typical spot- photosphere surface brightness ratios in the NIR (~0.5). The depth and bread of the deviations are improved when incorporating polar spots. Our most extreme cases likely require obscuring dust. In summary, our spectra suggest the presence of: • Large, high-contrast (dark) spots near equator • Large polar spots • Potentially, obscuring dust Our sparsely sampled spectra highlight CPVs as prime candidates for future Doppler tomographic studies to fully reconstruct the stellar surface, and to measure the orientation and size of the transiting material. Resolution Element Rotational Phase Rotation Periods since K2 Signature of Dark Spots (or Obscuring Material) No evidence for RV variability Flux compared to a homogeneous surface Typical Residual Depth vsini Acknowledgements & References BMT acknowledges the Heising-Simons Foundation, and TESS Cycle 3 & 4 Guest Investigator Grants (80NSSC21K0780, 80NSSC22K0302) [1] – Bouma et al. 2024, AJ, 167, 38 [2] – Stauffer et al. 2017, AJ, 151,60 [3] – Zhan et al. 2019, ApJ 876, 127 [4] – Mace et al. 2016, SPIE, Vol. 9908 [5] – Mace et al. 2018, SPIE, Vol. 10702 [6] – Rizzuto et al. 2015 MNRAS,448, 2737 [7] – Tofflemire et al. 2019, AJ, 148, 245


1 2 3 4 5 6 7 8 BTSA** 1 et 2 Licence de biologie générale 2 et 3 Master 1 et 2 en Microbiologie Doctorat Nutrition animale, parasitisme et environnement BTSA** 1 et 2 Classe préparatoire ATS* École d’ingénieur Agroalimentaire- Agronomie Doctorat Nutrition animale et qualité des produits laitiers Doctorat Microbiologie et santé animale Doctorat Nutrition animale et qualité des produits laitiers École d’ingénieur en Agriculture avec classes préparatoires intégrées Master 1 et 2 en Sciences Animales Licence de biologie générale 1, 2 et 3 Master 1 et 2 en Microbiologie Doctorat Sélection génétique et santé animale École d’ingénieur en Agriculture avec classes préparatoires intégrées Lucie Laurianne Valentin Blandine Des parcours variés vers le doctorat (bac+8), à toi de créer le tien ! Bac *ATS : Adaptation de Technicien Supérieur **BTSA : Brevet de Technicien Supérieu r Agricole Clément Centre Auvergne Rhône Alpes - Theix Route de Theix 63122 Saint-Genès-Champanelle, France Tel.: +33 (0)4 73 62 40 00


Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation in Saccharomyces cerevisiae Faeze Saatchi1*, Ann L. Kirchmaier1 1 Department of Biochemistry and Purdue Center for Cancer Research , Purdue University, West Lafayette, IN 47907 *Current address: Department of Internal Medicine, Kidney Cancer Research Program, UT Southwestern Medical Center, Dallas, TX 75235 Abstract Conclusions Introduction me me Ku70/80 me me FH Ku70/80 H2A H2A H2A.Z H2A.ZH3K36H3K36 FH H2A H2A.Z H2A H2A.Z Malate Fumarate KDM2B Malate Fumarate Figure 1. Upon DNA damage, fumarase (FH) is recruited to sites of double stranded break (DSB) through interaction with the histone variant H2A.Z. Fumarate generated by DSB-associated FH acts as an inhibitor of α- ketoglutarate-dependent histone demethylase KDM2B causing an increase of H3 K36 methylation at DSBs. This, in turn, promotes binding of Ku70/80 to DSB ends and enhances DSB repair by NHEJ. Sensitivity of htz1Δ mutants to DNA replication stress caused by HU is suppressed by high cellular levels of the metabolite fumarate (achieved by addition of exogenous fumarate or deletion of Fumarase, Fum1p) Figure 3. Cells with genotypes as indicated were grown overnight in rich (YPD) medium, then 3 ul of 10-fold serial dilutions were spotted onto YPD medium containing the indicated concentrations of fumarate and/or HU, and incubated at 30°C for 2 days prior to imaging. Loss of JmjC domain-containing histone demethylase Jhd2p suppresses the sensitivity to DNA replication stress of htz1Δ mutants. Results Our study uncovers links between the metabolic enzyme fumarase plus the metabolite fumarate and chromatin modifications during DNA damage response in Saccharomyces cerevisiae. In mammalian cells, fumarase becomes enriched at sites of double stranded break (DSB) through interaction with the histone variant H2A.Z. At DSBs, fumarase promotes DNA repair by nonhomologous end joining (NHEJ) by local production of fumarate which in turn acts as an inhibitor of KDM2B, a H3 K36-specific histone demethylase. We have demonstrated that treatment with hydroxyurea (HU), which creates stalled replication forks by depletion of nucleotides, leads to upregulation as well as nuclear enrichment of Fum1p. We have also shown that increased cellular levels of fumarate (upon deletion of FUM1 or addition of exogenous fumarate) suppresses the sensitivity to HU in htz1Δ mutants in a manner that is independent of modulating nucleotide levels. In fact, fumarate confers resistance to HU in htz1Δ mutants by inhibition of the H3 K4-specific histone demethylase Jhd2p, and increasing H3 K4 methylation levels. Sensors and mediators of the DNA replication checkpoint were required for fumarate- dependent resistance to HU in htz1Δ whereas factors involved in processing of regressed replication forks were dispensable. Together, our findings imply that high cellular levels of fumarate support processing of replicative intermediates by regulation of histone methylation, thereby promoting genome integrity. Fumarase is induced and becomes enriched in the nuclear fraction upon exposure to hydroxyurea (HU) Fumarate modulates levels of JDH2-dependent H3 K4 methylation. Figure 4. Strains with indicated genotypes were analyzed in serial dilution growth assays as described in Figure 3 YKu70p is not required for suppression of sensitivity of htz1Δ mutants to DNA replication stress by fumarate. Figure 2. Yeast expressing Fum1-GFPp were incubated in the absence or presence of 200 mM HU at 30°C for 3 hr. Whole cell extracts (A), or nuclear fractions (B) were analyzed by immunoblotting using anti-GFP, and anti-PCNA antibodies. A representative immunoblot and fold enrichment of Fum1p from two independent experiments is shown. Levels of Fum1-GFPp were normalized to levels of PCNA (loading control), then expressed relative to signal that was observed in the absence of HU, which was set to 1. Figure 5. (A) Enhancing histone methyl


NuSTARConstrainstheOriginofGammaRays inRSOph Marina Orio1,2, G. Juan M. Luna3 1. U Wisconsin and INAF-Padova, 2. orio@astro.wisc.edu, 3. CONICET, Buenos Aires and Hurlingham Universities Introduction RS Oph is arguably the best known recurrent symbiotic nova. Classical and recurrent novae occur in white dwarf binaries. The outbursts are attributed to a thermonuclear runaway on the surface of the WD, that has accreted ma- terial from the binary companion. A radiation- driven wind follows, depleting the accreted enve- lope [1, 2]. The designation “recurrent” implies that the outburst is observed more than once over human life timescales, and in RS Oph case outbursts were recorded in 1898, 1933, 1958, 1967, 1985, and 2006. RS Oph is also a sym- biotic system, hosting a red giant M0-2 III mass donor companion [3, 4] in a binary with a 453.6 day orbital period [5]. The NuSTAR observation We obtained a Director Discretionary Time NuSTAR 40 ks exposure in the 3-79 keV range on 2021 August 17, day 10 of the outburst ( it was impossible to schedule the exposure earlier, when the source may have been harder). The X-ray ﬂux was expected from colliding winds, presumably the high velocity ejecta impacting the slow red giant wind. One of the most in- teresting facts of this phase is the gamma-ray ﬂux, measured with Fermi in the GeV range and with HESS up to tens of GeV [6]. During the NuSTAR observation, several short exposures were done with NICER. Most important, for the ﬁrst time, a nova was observed at the same time also in gamma rays with Fermi and with Cherenkov telescopes [6]. References [1] S. Starrﬁeld, F. X. Timmes, C. Iliadis, W. R. Hix, W. D. Arnett, C. Meakin, and W. M. Sparks. Hy- drodynamic Studies of the Evolution of Recurrent, Symbiotic and Dwarf Novae: the White Dwarf Com- ponents are Growing in Mass. Baltic Astronomy, 21:76–87, January 2012. [2] William M. Wolf, Lars Bildsten, Jared Brooks, and Bill Paxton. Hydrogen Burning on Accreting White Dwarfs: Stability, Recurrent Novae, and the Post- nova Supersoft Phase. ApJ, 777(2):136, November 2013. [3] Danuta Dobrzycka, Scott J. Kenyon, Daniel Proga, Joanna Mikolajewska, and Richard A. Wade. The Hot Component of RS Ophiuchi. AJ, 111:2090, May 1996. [4] G. C. Anupama and J. Mikołajewska. Recurrent no- vae at quiescence: systems with giant secondaries. A&A, 344:177–187, April 1999. [5] E. Brandi, C. Quiroga, J. Mikołajewska, O. E. Ferrer, and L. G. García. Spectroscopic orbits and variations of RS Ophiuchi. A&A, 497(3):815–825, April 2009. [6] H. E. S. S. Collaboration. Time-resolved hadronic particle acceleration in the recurrent nova RS Ophi- uchi. Science, 376(6588):77–80, April 2022. [7] Indrek Vurm and Brian D. Metzger. High-energy Emission from Nonrelativistic Radiative Shocks: Ap- plication to Gamma-Ray Novae. ApJ, 852(1):62, Jan- uary 2018. [8] Gary Wegner, Joseph P. Cassinelli, and George Wallerstein. Shockwave Models for the Outburst of the Repeating Nova, RS Ophiuchi. In Bulletin of the American Astronomical Society, volume 1, page 209, March 1969. [9] S. Orlando, J. J. Drake, and J. M. Laming. Three- dimensional modeling of the asymmetric blast wave from the 2006 outburst of RS Ophiuchi: Early X-ray emission. ApJ, 493(3):1049–1059, January 2009. Conclusions The low maximum temperature measured with NICER rules out that the site of the X-ray emission is the same as the site of the gamma-ray emission. In fact, the energetics of novae are such that the shock temperature may be in the hard X-ray range, but gamma rays due either to inverse Compton eﬀect (leptonic mechanism) or to particle acceleration in the shock (causing pion decay; hadronic mechanism) are only associated with a very hard X-ray spectrum, with conspicuous ﬂux up to 80 keV. The site of the gamma-ray emission was thus optically thick even to very hard X-rays. In the 40-79 keV range, we have upper limits of 3 ×10−4 cts s−1 in NuSTAR. Assuming an initial X-ray ﬂux above 10−9 erg cm−2, consistent with Fermi


RESEARCH POSTER PRESENTATION DESIGN © 2012 www.PosterPresentations.com In developing countries, Clinical Research is considered a luxurious interest with lower priority. Ongoing studies show considerable gap in responses between developed countries where most research is conducted and developing countries where most of needy population is located. Background and Significance Purpose This process proved effective and necessitated developing tools for providing more comprehensive treatment roadmaps and tracking patients’ treatment milestones. Another advantage of applying the system is the improvement of medical team conduct knowing that their performance is being reviewed in what’s known as Hawthorne Effect. With the establishment of first research informatics unit in the region Monitoring process became live web-based activity where performance and survival can be monitored instantaneously. Method Within five years we’ve developed a model example for developing countries to improve clinical practice through integrating research methods and informatics. Dealing with all treatment regimens as research protocol with the integration of audit and feedback approach in the treatment process definitely improves treatment outcome most specifically at poorly established settings. Conclusion We demonstrate a case where practice was improved in a multi-disciplinary cancer center through setting the institution vision and objectives to be patient centered, research focused and outcome oriented. Research Clinical 2008 • Starting Protocol development and Monitoring Unit • Data collection using MS Excel 2008-2009 • Access databases (local) • Databases shared over network. 2009 • In-House development of Web-based application for electronic data capture. Each protocol is digitized. 2010 • Development of Web-based plug-in for mobile / handheld devices and real-time analysis. • Task manager • Cancer Registry 2011 • Violation Reporting / Patient safety 2012 • Joining RedCap open source Consortium • IRB submission and review online system • Research Online Training Management System. • Research and Clinical Pharmacy eLearning module 2007 • RIS: Radiology Information System. • PACS: Picture archiving and communicatio n system • LIS: Lab Information System 2007-2009 • Paper based patient charts. 2009 • Implementing Electronic medical Record System. Research Department, Children's Cancer Hospital 57357 - Egypt. Research Department, Children's Cancer Hospital 57357 - Egypt. A.S. Alfaar, M. Kamal, O. Hassanain, M. Sabry, S. Ezzat, S. Abouelnaga Advancing Clinical Oncology Practice in Developing Countries: Integrating Research Informatics for Continuous Process Improvement. Advancing Clinical Oncology Practice in Developing Countries: Integrating Research Informatics for Continuous Process Improvement. Since the development of the Protocol Monitoring unit and the Research Department, a monitoring process has been established which identified violations and deviations from the developed clinical protocols with a continuous feedback to the attending treatment and research teams i.e. treating each treatment regimen as a research protocol. 2008 Paper File 2011 Electronic research systems Pictures are graphically manipulated for protecting patients’ privacy No Conflict Of Interest To Be Declared By Authors Telemedicine Live Stat’s The customized treatment protocols were developed through identifying key evidence-based practices, integrating it with research questions and local clinical expertise. Cooperation with international centers like St. Jude Children’s Research hospital and Dana Farber Cancer Institute as well as Children’s Hospital-Boston has supported our transition into an international center through benchmarking and training. Acknowledgement This Poster is Supported by Travel Grant From ESMO Contact Us: mohamedkamalpharm@gmail.com asamir@57357research.com msabrybakry@gmail.com N.B. The team is all MDs and Pharmacists No IT members. Portal Dashboar


Eingangsformel Der Parlamentarische Rat hat am 23. Mai 1949 in Bonn am Rhein in öffentlicher Sitzung festgestellt, daß das am 8. Mai des Jahres 1949 vom Parlamentarischen Rat beschlossene Grundgesetz für die Bundesrepublik Deutschland in der Woche vom 16. bis 22. Mai 1949 durch die Volksvertretungen von mehr als Zweidritteln der beteiligten deutschen Länder angenommen worden ist. Auf Grund dieser Feststellung hat der Parlamentarische Rat, vertreten durch seine Präsidenten, das Grundgesetz ausgefertigt und verkündet. Das Grundgesetz wird hiermit gemäß Artikel 145 Abs. 3 im Bundesgesetzblatt veröffentlicht: Präambel Im Bewußtsein seiner Verantwortung vor Gott und den Menschen, von dem Willen beseelt, seine nationale und staatliche Einheit zu wahren und als gleichberechtigtes Glied in einem vereinten Europa dem Frieden der Welt zu dienen, hat sich das Deutsche Volk in den Ländern Baden, Bayern, Bremen, Hamburg, Hessen, Niedersachsen, Nordrhein-Westfalen, Rheinland-Pfalz, Schleswig-Holstein, Württem- berg-Baden und Württemberg-Hohenzollern, um dem staatlichen Leben für eine Übergangs- zeit eine neue Ordnung zu geben, kraft seiner verfassungsgebenden Gewalt dieses Grund- gesetz der Bundesrepublik Deutschland beschlossen. gegeben. Es hat auch für jene Deutschen gehandelt, denen mitzuwirken versagt war. Das gesamte Deutsche Volk bleibt aufgefordert, Die Deutschen in den Ländern Baden- Württemberg, Bayern, Berlin, Brandenburg, Bremen, Hamburg, Hessen, Mecklenburg- Vorpommern, Niedersachsen, Nordrhein- Westfalen, Rheinland-Pfalz, Saarland, Sachsen, Sachsen-Anhalt, Schleswig-Holstein und Thüringen haben in freier Selbstbestimmung die Einheit und Freiheit Deutschlands zu vollenden vollendet. Damit gilt dieses Grundgesetz für das gesamte Deutsche Volk. I. Die Grundrechte Artikel 1 (1) Die Würde des Menschen ist unantastbar. Sie zu achten und zu schützen ist Verpflichtung aller staatlichen Gewalt. (2) Das Deutsche Volk bekennt sich darum zu unverletzlichen und unveräußerlichen Men- schenrechten als Grundlage jeder menschlichen Gemeinschaft, des Friedens und der Gerech- tigkeit in der Welt. (3) Die nachfolgenden Grundrechte binden Gesetzgebung, Verwaltung vollziehende Gewalt und Rechtsprechung als unmittelbar geltendes Recht. Artikel 2 (1) Jeder hat das Recht auf die freie Entfaltung seiner Persönlichkeit, soweit er nicht die Rechte anderer verletzt und nicht gegen die verfassungs- mäßige Ordnung oder das Sittengesetz verstößt. (2) Jeder hat das Recht auf Leben und körperliche Unversehrtheit. Die Freiheit der Person ist unverletzlich. In diese Rechte darf nur auf Grund eines Gesetzes eingegriffen werden. Artikel 3 (1) Alle Menschen sind vor dem Gesetz gleich. (2) Männer und Frauen sind gleichberechtigt. Der Staat fördert die tatsächliche Durchsetzung der Gleichberechtigung von Frauen und Män- nern und wirkt auf die Beseitigung bestehender Nachteile hin. (3) Niemand darf wegen seines Geschlechtes, seiner Abstammung, seiner Rasse, seiner Sprache, seiner Heimat und Herkunft, seines Glaubens, seiner religiösen oder politischen An- schauungen benachteiligt oder bevorzugt wer- den. Niemand darf wegen seiner Behinderung benachteiligt werden. Artikel 4 (1) Die Freiheit des Glaubens, des Gewissens und die Freiheit des religiösen und weltan- schaulichen Bekenntnisses sind unverletzlich. (2) Die ungestörte Religionsausübung wird ge- währleistet. (3) Niemand darf gegen sein Gewissen zum Kriegsdienst mit der Waffe gezwungen werden. Das Nähere regelt ein Bundesgesetz. Artikel 5 (1) Jeder hat das Recht, seine Meinung in Wort, Schrift und Bild frei zu äußern und zu verbreiten und sich aus allgemein zugänglichen Quellen ungehindert zu unterrichten. Die Pressefreiheit und die Freiheit der Berichterstattung durch Rundfunk und Film werden gewährleistet. Eine Zensur findet nicht statt. (2) Diese Rechte finden ihre Schranken in den Vorschriften der allgemeinen Gesetze, den gesetzlichen Bestimmungen zum Schutze der Jugend und in dem Recht der persönlichen Ehre. (


DIE STORY IN DEN DATEN Robert Köpke IfL Leipzig Unser Use Case Im Projekt arbeitet das IfL an der Entwicklung von Visualisierungsformaten und der kritischen Analyse von Biodiversitätsdatensätzen. Das IfL entwickelt (raumbezogene) Visualisierungen sowie Methoden des visuellen Storytellings, um komplexe Datensätze verständlich darzustellen und unterschiedleiche Zielgruppen zu adressieren. Girlitz im Blick Seit vielen Jahren führt der DDA das Monitoring häufiger Brutvögel durch, unterstützt von zahlreichen geschulten Freiwilligen. Diese Story beleuchtet, wie die gesammelten Daten verarbeitet werden und welche Schlüsse daraus gezogen werden können, insbesondere im Hinblick auf den rückläufigen Brutbestand des Girlitz. Sie erzählt von den langfristigen Erkenntnissen aus Jahrzehnten der Datenerhebung und zeigt, wie Technik die Arbeit erleichtert. Von Ruf und Realität Die Süßwasserfische Brachse und Äsche, obwohl häufig vorkommend, erleben einen Bestandsrückgang. Die länderübergreifende Auswertung von Bestandsdaten, wie sie das Projekt NFDI4Biodiversity vornimmt, ermöglicht es, solche Entwicklungen frühzeitig zu erkennen und Schutzmaßnahmen einzuleiten. Diese Story zeigt am Beispiel dieser Fischarten das Potenzial der einheitlichen Datenverarbeitung für den Biodiversitätsschutz. DATENGRUNDLAGE - Harmonisierter Fischmonitoring- Datensatz ZIELGRUPPE - Wissenschaftler :innen - Fachpublikum FORSCHUNGSFRAGE Kartographische Methoden zur Visua- lisierung von Unsi- cherheiten in Vorkom- mensdaten und deren Einfluss auf Interpretation und Entscheidungsfindung. DATENGRUNDLAGE - Testflächen Monitoring häufiger Brutvögel ZIELGRUPPE - Ausgebildete Helfer:innen - Breite Öffentlichkeit FORSCHUNGSFRAGE Wie können räumliche Analysemethoden ein- gesetzt werden, um Muster und Trends zu identifizieren? Data Storys Die Verwendung von digitalem Storytelling, das Karten, Infografiken und Bilder einsetzt, ist eine effektive Methode, um Inhalte für verschiedene Zielgruppen ansprechend zu gestalten. Möglichkeiten Verbesserte Entscheidungsfindung: Erleichtern das Verständnis komplexer Daten, unterstützen so umweltpolitische und wissenschaftliche Entscheidungen. Interaktive Lernerfahrung: Multimedia-Elemente wie Videos, interaktiven Karten und Animationen können Nutzer die Daten erfahren lassen. Forschung und wissenschaftliche Analyse: Kann neue Muster und Zusammenhänge in Biodiversitätsdaten kommunizieren. Herausforderungen Zeitliche Dynamik: Darstellung von zeitlichen Veränderungen und Aktualität Interdisziplinäre Integration: Zusammenführung von Expertenwissen Darstellung von Unsicherheiten: Um Fehlinterpretationen zu vermeiden und ein realistisches Bild zu vermitteln. Dateninterpretation und -verfügbarkeit: Sicherstellung der Genauigkeit, Aktualität und Vollständigkeit der Daten.


Seminar für Ägyptologie und Koptologie (Re-)Konstruktion der Lübecker Aegyptiaca – Didaktische Perspektiven auf gegenständliche Quellen in der Ägyptologie Nina Wagenknecht, M.A. E-Mail: nina.wagenknecht@stud.uni-goettingen.de Erstbetreuung: apl. Prof. Dr. Heike Sternberg-el Hotabi, Seminar für Ägyptologie und Koptologie Zweitbetreuung: Prof. Dr. Michael Sauer, Seminar für Mittlere und Neuere Geschichte •Thema und Zielgruppe festlegen •Vermittlungsziele des Themas formulieren •Objekte auf Basis des Themas auswählen Thema und Zielgruppe der Ausstellung •Kontextualisierung von Verwendungsweisen und Datierung der Objekte •Rekonstruktion der Erwerbsumstände der Objekte Fachwissenschaftliche Sachanalyse •Erarbeitung der Umsetzungsformate unter Einbezug von Medienwahl, - wechsel und Barrierefreiheit •Ausarbeitung der digitalen Präsentation der Objekte in Microsoft Access Didaktische Analyse Methodisches Vorgehen Thema und Ziele der Arbeit Im Rahmen des Dissertationsvorhabens wird ein Online- Vermittlungskonzept für die nicht physisch ausgestellten Aegyptiaca der Völkerkundesammlung der Lübecker Museen erarbeitet. Zentrale Ziele dabei sind: • Die Übertragung methodischer Schritte zur Vermittlung gegenständlicher Quellen aus der Geschichtsdidaktik zur Erarbeitung zusammenhängender Lernmaterialien. • Erstellung eines Vermittlungskonzeptes thematisch ausgewählter Aegyptiaca unter Einbezug einer kritischen Reflexion der Sammlungsgeschichte. Materialbasis Inhalt der Sammlung: 338 Aegyptiaca (415 Objekte einschließlich Verluste). Erwartete Ergebnisse 1. Inhaltliches Ergebnis: Ein Online-Konzept, das einen ausgewählten Teil des Bestandes der Lübecker Aegyptiaca der Öffentlichkeit thematisch aufbereitet zugänglich macht und dabei die Verbindung der Objekte zur Sammlungsgeschichte der Völkerkundesammlung kritisch einordnet. 2. Methodisches Ergebnis: Systematische Erschließung neuer Formate der Wissensvermittlung auf Basis der Struktur von Bestandskatalogen, die auf weitere Sammlungen übertragen werden kann. Zeitphase Anzahl Beispiele für Objekte Paläolithische Zeit 49 Flint- und Hornsteinobjekte Prädynastische Zeit 40 Tonkrüge, Haarnadel, Schminkpalette Frühdynastische Zeit 9 Flintwerkzeuge Altes Reich 8 Modell-Opferteller Mittleres Reich 3 Koḥl-Gefäß Neues Reich 11 Grabziegel, Umschlagtuch, Wandbruchstück Spätzeit 96 Gewichtsteine, Kaurischnecken, Figur-Sockel Ptolemäische Zeit 20 Amulette, Öllampen, Ostrakon, Vogelmumie Römische Zeit 61 Würfel, Spinnwirtel, Schreibtafel, Brotstempel Frühislamische Zeit 6 Koptische Textilien Unklare Datierung 12 Skarabäen, Torso einer Königs-Statuette 19./20./21. Jahrhundert 23 Fälschungen, Repliken Literatur Falck, Martin von. 2011. „Museologischer Anspruch und museumsägyptologische Wirklichkeit“. In: Verbovsek, Alexandra, Burkhard Backes und Catherine Jones, Hrsgg. Methodik und Didaktik in der Ägyptologie. Herausforderungen eines kulturwissenschaftlichen Paradigmenwechsels in den Altertumswissenschaften. Ägyptologie und Kulturwissenschaft IV. München: Fink, 405–422. Germer, Renate. 2018. Die altägyptischen Objekte der Völkerkundesammlung der Hansestadt Lübeck: Ein Kurzkatalog zusammengestellt von Renate Germer, <https://vks.die-luebecker-museen.de/file/die_altaegyptischen_objekte__kompl_zusammengefasst.pdf> (Zugriff: Juli 2020). Röttele, Hannah. 2020. „Objektbegegnungen“ im historischen Museum: eine empirische Studie zum Wahrnehmungs- und Rezeptionsverhalten von Schüler_innen. München: kopaed.


APPROACH The textile sector is undergoing a set of transformations to shift to a circular model. Within the framework of the TRICK project, an innovative approach to traceability and sustainability in textile supply chains has been developed. BACKGROUND OUTCOMES INDUSTRIAL PILOTS – CIRCULAR APPROACH The data model validation has been done through two pilots, one for the classical fashion segment and the other for the technical work-wear segment aiming to get the necessary data from a fragmented supply chain. The pilots began with the production of the goods made from virgin raw materials; the obtained garments, which usage was simulated, then were mechanically recycled. The obtained secondary raw materials include a percentage of the recycled goods; they were used to obtain garments of the same model whose characteristics were analyzed. The pilots started by an initial data gathering from the industrial users' internal system, a data validation and the mapping to the data model for its refinement. Then traceability reports were created by modeling data and reporting the product’s history. The collected data was also used to perform a PEF study across the whole supply chain. CONCLUSIONS AND NEXT STEPS The holistic approach to data collection covering traceability and sustainability data allows to easily meet the requirements from new normative: it is the case of ESPR and Digital Product Passport (DPP) enforcing a sustainable approach to production and, in parallel, more efficacy of the market surveillance authorities. The next steps will be to validate TRICK efficacy in collecting faithful data to fuel the creation of digital product passport contents from the fragmented textile supply chains. On this purpose a CEN Workshop process will be launched to share and improve such contents and contribute with a public pre- standardization activity to the establishment of a framework for collecting faithful data to support the DPP statements of the fashion firms. A Traceability Report for the data collections on the events is the TRICK response to the requirements emerged from the pilot supply chains to overcome the barriers, criticalities and needs highlighted by industrial partners involved in the project. In respect of the EPCGlobal EPCIS and UNECE event models, its Enriched Event-based Model: - offers a plurality of product and lot identification methods and a more detailed process step description with a shared taxonomy of manufacturing operations - supports the collection of the events from a wide range of heterogeneous systems, covering the many tiers of the supply chain - enforces a triangle of synergies among usual daily operations, blockchain technology and business services of a traceability platform and its disclosure policies. Enhancing Traceability and Faithfulness of Sustainability Data in the Textile and Clothing Supply Chain through Blockchain and a Standard Based Enriched Event Model Gessica Ciaccio (1), Carla Fité Galan (2), Piero De Sabbata (1), Arianna Brutti (1) (1) Italian National Agency for New Technology, Energy and Sustainable Economic Development, ENEA, TERIN-SEN-CROSS Laboratory, via dei Mille 21, 40121, Bologna, Italy (2) Polytechnic University of Catalonia (UPC), Systems and Processes lab of the Textile Research Institute of Terrassa (INTEXTER), Carrer Colom 15, 08222, Terrassa, Spain This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 958352 Fig. 5 Representation of a circular approach of the textile pilots in the TRICK project CONTACTS Gessica Ciaccio, gessica.ciaccio@gmail.com Carla Fité Galan, Carla.fite@upc.edu Piero De Sabbata, piero.desabbata@gmail.com In parallel the Transparency and Sustainability Report is the core of the Transparency and Sustainability data collection. It collects all the available non- operational data about Product and Organization and shares the data groups related to sustainability with specific


Protect Bees, Save the Future I. Madaleno1, S. Branco1, students from 10th Grade Mechatronics1 1Externato Cooperativo da Benedita, Benedita, Portugal Abstract In this project students built a hive by adapting remote control systems for its internal environment (temperature and humidity) and external environment (door, fire, location). The solution was aimed at beekeepers, and anyone interested in getting started in the beekeeping industry. The main goals of the project were to facilitate the work of beekeepers and to improve the management, control and monitoring of hives. The solution created is feasible and satisfies the project's objectives. Keywords Automation; bees; electronics; robotics; sustainability.


Direct Dark Matter Search with the CRESST-III Experiment Michael Willers on behalf of the CRESST collaboration Physik-Department and Excellence Cluster Universe, Technische Universität München, 85748 Garching The CRESST-III Experiment The CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) [1, 2] experiment aims for the direct detection of Dark Matter (DM) particles via elastic scattering off nuclei in CaWO4. CRESST-III, the current stage of the experiment, searches for low-mass (M ≲10 GeV/c2) DM particles and ultimately aims to probe the parameter space down to the neutrino ﬂoor. The experiment is located in the Gran Sasso National Laboratory (LNGS), Italy, shielded against cosmic rays by ∼3600 m.w.e. of rock overburden. CRESST uses a multi-element target: scintillating CaWO4 single crystals operated as cryogenic detectors. Requirements for probing low-mass DM particles: • sub-keV energy threshold due to low momentum transfer to target crystal. • Low background rate in region of interest and good background suppression capabilities. CaWO4 target crystal: • Block-shaped CaWO4 crystal (20 × 20 × 10) mm3, Mass 25g. • Sensitivity gain due to reduced heat capacity and adapted TES design. Silicon-On-Sapphire light detector: simultaneous measurement of phonon- and light-signal enables particle identiﬁcation and background suppression. plain CaWO4 stick holding light detector Copper housing with reﬂective and scintillating inner surface (3M® Vikuiti foil [3]). Tungsten (W) TES Instrumented CaWO4 sticks (iStick) holding the CaWO4 target crystal: • events within the CaWO4 sticks are a potential back- ground for low-mass DM search. • instrumentation enables ef- ﬁcient veto of these events. • 3 iStick per module (1 read- out channel). Recent results from CRESST III phase 1 CRESST-III phase 1 started in summer of 2016 with an initial campaign to set-up and calibrate the detectors. The physics run of phase 1 started in September of 2016. • 10 detector modules installed. • 8 modules with TUM-grown crystals, 2 with commercial crystals. • 5 modules reached / exceeded design goal of 100eV nu- clear recoil energy threshold. • Detector A has lowest threshold in CRESST-III phase 1. First analysis of detector A • Data taking period: Oct. 2016 - May 2017 • Gross exposure (before cuts): 2.39 kg days • Blind analysis with non-blind training set (20% randomly selected, excluded from DM data set). Training set data used to deﬁne cuts. • Conservative analysis threshold of 100 eV. • Data quality (rate, stability, unphysical events) and coincidence (µ- veto and iStick) cuts applied. 79.5% survival probability at 100eV. • Limit on DM-nucleon cross-section calculated using Yellin’s optimal interval method [4] →sensitivity extended to lower DM masses (lim- ited by non-ﬂat background at low energies). The analysis of the full dataset as well as a low-threshold analysis are currently ongoing. Furthermore, the application of optimum ﬁltering to a stream of continuously acquired data is investigated with the goal of improving the trigger threshold of the detectors [5]. Data taken with detector A in the light yield - energy plane e−/γ-band recoils off oxygen recoils off tungsten dark matter acceptance region Low-energy spectrum of all events recorded with detector A CaWO4 crystal growth at TUM A high radio-purity of the CaWO4 crystals is es- sential for CRESST. In order to have full control of all crystal growth parameters, TUM has estab- lished a complete in-house CaWO4 crystal growth process [6]: • Powder production via solid state reaction or precipitation including chemical puriﬁcation (net reaction: CaCO3 + WO3 →CaWO4 + CO2). • Crystal growth in dedicated Czochralski fur- nace. • Annealing of grown ingots in pure O2 atmo- sphere. • Cutting and polishing of target crystals. In addition, recrystallisation of grown crystals is investigated as a measure to further improve the radio-purity of the CaWO4 crystals [7, 8]. Czochralski Furnace & raw


Are You Catching Cosmic Rays or Just Checking Messages? Towards an Extremely Distributed Mobile Phone Cosmic Ray Observatory Carlyn Lee and Harvey Newman Division of Physics, Mathematics and Astronomy, California Institute of Technology, CA, USA Contact: Carlyn Lee Email: cblee@caltech.edu https://github.com/carlynlee/credo-api-tools/tree/playground/ References 1. Martın Abadi, et al., TensorFlow: Large-scale machine learning on heterogeneous systems, 2015. Software available from tensorflow.org. 2. Piotr Homola, et al., Cosmic-ray extremely dis- tributed observatory. Symmetry, 2020. 3. Jennifer Ngadiuba, et al., Compressing deep neural networks on fpgas to binary and ternary precision with hls4ml. Machine Learning: Science and Technology, 2(1):015001, Dec 2020. 4. Daniel Whiteson, et al., Searching for ultra-high energy cosmic rays with smartphones, Astroparticle Physics, Volume 79, 2016, Pages 1-9, ISSN 0927-6505. This project aims to design an architecture for applying Federated Learning (FL) to the analysis of cosmic ray event data collected through the Cosmic Ray Extremely Distributed Observatory (CREDO) project. CREDO gathers data from a global network of smartphones, enabling a large-scale citizen science initiative to study cosmic rays. The traditional approach of centralizing this data raises concerns about privacy and data ownership. We explore as a potential solution, allowing decentralized training of machine learning models directly on participants’ devices. We explore how FL can accommodate CREDO's requirements, such as handling heterogeneous data and robust model aggregation. We present our initial steps in designing an FL architecture tailored to the needs of the CREDO project, outline our architectural proposal, and discussing the potential benefits and the technical challenges. This sets the stage for future implementation and evaluation, aiming to enhance accountability and collaboration in scientific data analysis. Abstract Cluster Identification: Identified and visualized ten distinct clusters, each representing different events triggering the CREDO app. Device Comparison: Analysis reveals variance in detection patterns across devices, possibly indicating differences in device sensitivity or environmental conditions. Data Retrieval: Elasticsearch for query and image retrieval. Data stored as base64 encoded strings, corresponding to different devices and time frames. Image Processing: Decoded images from base64 format and resized to uniform dimensions for consistent analysis. Performed clustering based on extracted features using a pre-trained model, adapted to identify distinct patterns within the data. Cluster Visualization: Python scripts to compute and display the mean image for each cluster across multiple devices, enhancing interpretability of clustering results. Tools: Python (NumPy, Matplotlib, Pillow), ResNet50 deep learning model. q Visual analysis leveraged clustering and image processing techniques to dissect cosmic ray detection data. This approach highlighted variations across different devices and conditions, revealing possible patterns through visual data exploration. Such insights can be critical for refining detection strategies and enhancing the overall understanding of cosmic ray distributions. Future Work q Enhance Model Accuracy: Improve machine learning models and clustering precision. q Dataset Expansion: Enlarge dataset scope and integrate real-time data analysis for dynamic insights. q Federated Learning Implementation: q Local Model Training: Enable devices to train locally, sharing only model updates to minimize bandwidth use and enhance privacy. q Scalability: Use federated learning to keep data on local devices, addressing privacy concerns and managing large data volumes. q Collaborative Advancements: Combine insights across diverse devices, enhancing detection pattern accuracy and variety. q Managing asynchronous updates to models Discussion and Conclusions Objective: To analy


RESULTS REFERENCES Geiser, E., Walker, K. M., & Bendor, D. (2014). Global timing: a conceptual framework to investigate the neural basis of rhythm perception in humans and non-human species. Front Psychol, 5. Gorgolewski, K., Burns, C. D., Madison, C., Clark, D., Halchenko, Y. O., Waskom, M. L., & Ghosh, S. S. (2011). Nipype: a flexible, lightweight and extensible neuroimaging data processing framework in python. Front Neuroinform, 5(3). Hanke, M., Halchenko, Y. O., Sederberg, P. B., Olivetti, E., Fründ, I., Rieger, J. W., ... & Pollmann, S. (2015). PyMVPA: a unifying approach to the analysis of neuroscientific data. Python in Neuroscience, 157. Kriegeskorte, N., Goebel, R., & Bandettini, P. (2006). Information-based functional brain mapping. Proc Natl Acad Sci USA, 103(10), 3863-3868. Stelzer, J., Chen, Y., & Turner, R. (2013). Statistical inference and multiple testing correction in classification-based multi-voxel pattern analysis (MVPA): random permutations and cluster size control. Neuroimage, 65, 69-82. INTRODUCTION • Humans are able to recognize a familiar rhythm, for example the rhythm of a song, independently of the tempo at which it is played. This is exemplary of the fact that auditory experiences comprise percepts of auditory Gestalt based on the rhythmic structure of sounds. • The pattern resulting from the relative temporal relationship between acoustic events is the basis for the perceptual emergence of temporal Gestalt. This Gestalt percept is invariant to the absolute temporal relationship between constituent acoustic events (Hulse et al. 1992). • It is unknown, where in the brain percepts of temporal Gestalt are generated. • A linear support vector machine (SVM) classifier was trained to differentiate activation patterns in functional Magnetic Resonance Imaging (fMRI) data to two different percepts, across different sensory constituents. • A searchlight analysis localized activation patterns specific to the temporal Gestalt. CONCLUSIONS →Based on brain activation patterns, a linear SVM classifier identified which relative temporal pattern had been presented. The classifier was trained across absolute temporal patterns (tempi) of sequences. -> The classifier had identified the neural activation pattern associated with the Gestalt percept. →Based on a searchlight analysis, activation patterns in the temporo-parietal junction (TPJ) (left and right hemisphere) and the inferior frontal gyrus (right hemisphere) discriminated between the two different temporally grouped percepts of temporal Gestalt. →Our findings reveal for the first time that both sensory and higher cortical areas encode temporal Gestalt. →The study provides an example of how we can tackle the neural basis of perceptual invariance using neuroimaging. METHODS EXPERIMENTAL SETUP • 19 volunteers underwent functional neuroimaging (fMRI). Where the rhythm plays: Machine learning decodes rhythm-sensitive cortices Michael P. Notter1,2, Michael Hanke3, Micah M. Murray1,2,4,5, Eveline Geiser1,6 1The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology and Department of Clinical Neurosciences, Vaudois University Hospital Center and University of Lausanne, Lausanne, Switzerland 2Electroencephalography Brain Mapping Core, Center for Biomedical Imaging of Lausanne and Geneva, Switzerland 3Psychoinformatics lab, Institute of Psychology II, Otto-von-Guericke-University and the Center for Behavioral Brain Sciences, Magdeburg, Germany 4Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland 5Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA 6McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA SCANNER SETUP • 3T Siemens scanner; 64-channel head coil (coverage shown on the right) • TR of 2s; 365 volumes x 5 sessions; 33 slices (ascending order) PREPROCESSING • Pre-processing was done with Nipype (Gorgolewski et al., 2011): despiking (A


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Materials and Methods Sarah K . Morris1†*; Oscar A. Pérez-Escobar1,2†*; Bente B. Klitgård1; Alexandre Antonelli1,2; Alejandro Zuluaga3; Monica Carlsen4; Eve J. Lucas1; Simon Mayo1; Anna Haigh1; Steven Dodsworth5; Olivier Maurin1; Grace Brewer1; Robyn Cowan1; Ilia J. Leitch1; Felix Forest1; William J. Baker1 The origin and diversification of the hyper-diverse flora in the Chocó biogeographic region Objectives Anthurium obtusilobum Silica-gel dried leaf fragments 13 outgroup 27 Anthurium DNA extraction, shearing, library preparation, pooling, hybridization and sequencing as described in Johnson et al. (2018) with Angiosperm353 bait kit HybPiper v 1.3.1 (with Spathiphyllum kochii reference) skimmed plastid genome data (39 Anthurium) multiple sequence alignment use full genomic alignment to constrain combined alignment for Maximum Likelihood tree Secondary calibration age of Pothoideae13 Petrocardium cerrejonense (55.8 Myr)8 divergence time estimation with BEAST v2.0 geographic occurrence data from GBIF ancestral range estimation comparing biogeographical models with R-package BioGeoBEARS v0.2.1 1Royal Botanic Gardens, Kew. TW9 3AE, London, UK 2Gothenburg Global Biodiversity Centre, Sweden 3Universidad del Valle, Colombia 4Missouri Botanical Garden, USA 5University of Bedfordshire, Luton, UK †these authors contributed equally to this study *corresponding authors: o.perez-escobar@kew.org, s.morris@kew.org Alwyn H. Gentry (Annals of the Missouri Botanical Garden, 1996) Geographic extension of the Chocó biogeographical region in Central and South America12 and its compound geological origin14 Extract loci from genomic alignments that match Sanger sequences from Carlsen & Croat (2013) Angiosperm 353 kit successfully enriched 50-333 nuclear genes (& recovered 93 plastid genes) species-tree coalescence analyses revealed extensive incongruence near the MRCA of Anthurium the timing and origin of the MRCA of Anthurium remains unclear multiple migrations into Chocó: 3 at ~9 Mya from Central America 1 at ~5 Mya from Amazonia multiple recent migrations within 1 My from Central America and northern Andes Were Gentry’s ideas about the mode and tempo of plant evolution into the Chocó correct? Chocoan flora is likely older than Gentry assumed (perhaps late Miocene) migrations occurred after rapid mountain building had begun in the northern Andes allopatric speciation due to Andean uplift unlikely origin of Chocoan flora from Central America and northern Andes is supported migrations split between 9 Mya and < 1 Mya, suggesting a burst of migration after the closure of the CAS and again more recently Gentry believed the habit type, dispersal system and pollination syndrome of the Chocoan flora allowed for rapid speciation of endemics7: shorter generation time of shrubby and herbaceous groups bird and mammal (more localized) dispersal specific pollinator relationships To investigate these biotic factors, we are conducting similar genomic studies of other representative groups, including Blakea (Melastomataceae) and Neotropical orchids14 key geologic events in mid-late Miocene: 1. accretion of the Chocó Block4 2. Northern Andean orogeny9 3. closure of the Central American Seaway (CAS)10 The Chocó Introduction Gentry from available floristic, geological and palynological data in the 80s: Chocoan flora originated in the mid- Pleistocene from Amazonian lineages which migrated around the northern Andes, through southern Central America 6 “the historical accident of the Andean uplift, with the concomitant opportunity for explosive speciation among certain taxa … may largely explain the “excess” plant species diversity of the Neotropics” 5 Test Gentry’s hypothesis with genomic data of Anthurium using phylogeny reconstruction, molecular dating and ancestral area estimation We expect to see: a MRCA for the Anthurium lineage in Amazonia a MRCA of Chocoan clades in the northern Andes and Central America migration into the Chocó in the Pleis


State-independent wind Wind-related features Observing a black hole transient Javier Sánchez-Sierras E-mail: javisansie@gmail.com Instituto de Astrofísica de Canarias Wind-type outflows from the black hole X-ray binary MAXI J1820+070: the near infrared view SOFT HARD X-ray winds (expected) Optical winds Near-infrared winds MAXI J1820+070 is a low-mass X-ray binary (LMXB) with a black hole of ~8M☉located very nearby, at only 3kpc. It was discovered during a bright outburst of the source in 2018, which showed a standard evolution in the Hardness-Intensity Diagram (see image below), passing through the main accretion states: hard and soft. THE SPECTRA We obtained 8 spectra using VLT/X-shooter, a spectrograph with a wide spectral range from optical to near-infrared (3000 Å – 24750 Å). These observations cover the different accretion states (soft, red; intermediate, green; hard, blue). Optical winds have been observed during the bright-hard state, which is consistent with previous studies in other LMXBs, such as V404Cyg, V4641Sgr or GRS 1716-249. The optical winds discovered during the hard state were observed in some optical lines, such as Ha or HeI-5876Å. The wind-related features observed include P-Cygni profiles and broad emission line wings, and they showed velocities of 1200-1800 km/s. NEAR-INFRARED SPECTRAL RANGE We analysed several near-infrared lines during the hard state and found wind-related features such as blue- shifted absorptions and broad emission line wings (see image above). These features showed similar kinetic properties to the optical ones. During the soft state, these wind features disappear in optical lines but remain visible in the near-infrared spectra. The presence of wind-related features in near-infrared lines during both hard and soft accretion states, with similar kinetic properties to the hard state optical ones, suggests that they are tracing the same wind. This state-independent wind changes its visibility depending on the conditions of the material (i.e. temperature, ionization level, ...). This idea can be seen in the sketch above, which shows the presence of the wind during the 2018 outburst of MAXI J1820+070. This represents one more step to complete the picture of winds in X-ray binary outbursts. Sánchez-Sierras J. 1,2, Muñoz-Darias T. 1,2 1 Instituto de Astrofísica de Canarias (Tenerife, Spain), 2 Universidad de La Laguna (Tenerife, Spain) Based on paper: Sánchez-Sierras & Muñoz-Darias, 2020, A&A 640 L3


SAW 2024 – Seeing and AcƟng Workshop: FuncƟonal and Neural PerspecƟves Poster Session 1 — September 27, Friday 1 – Visually guided acƟons survive bilateral lesions of the occipitotemporal cortex: evidence from behavioural and tractography Authors: Ana C. Torres Cresto, Marine Keime, Alessandro Vinciarelli, Melvyn A Goodale, Jody C. Culham, Cassandra Sampaio-BapƟsta, Monika Harvey 2 – EvoluƟonary approaches for audio-visual associaƟons Authors: Ana Rodrigues, Amílcar Cardoso, Penousal Machado 3 – Seeing speech: Probing the cerebral mechanisms of Cued Speech percepƟon Authors: Annahita Sarré, Laurent Cohen 4 – Using ultra-high resoluƟon MRI to uncover the underlying microstructural mechanisms of structural plasƟcity in blind humans Authors: Anna-Lena Stroh, Daniel Haenelt, Luke J. Edwards, Fakhereh Movahedian AƩar, Kerrin J. Pine, Robert Trampel, Marcin Szwed, Nikolaus Weiskopf 5 – DiﬀerenƟal modulaƟon of serial dependence by acƟon percepƟon integraƟon in auƟsm spectrum traits in a dynamic VR task Authors: Antonella Pomè, Michael Wiesing, Rebecca Süther, Eckart Zimmermann 6 – Does Observing Bodily Movement Contribute to Developing Goal Comprehension? Authors: Ben-Ami Shlomit, Verma Dhun, Lall Naviya, Ganesh Suma Ralekar Chetan, Gilad- Gutnick Sharon, Sinha Pawan 7 – Touch localizaƟon aŌer nerve repair: Longitudinal measures reveal high individual variability Authors: Benjamin Govier, MarƟn Weber, Andrew Marshall, Obi Onyekwelu, Louise Booth, Edwin Jesudason, Vivien Lees, Ken Valyear 8 – FuncƟonal organisaƟon of sensorimotor regions in people with congenital facial paralysis (Moebius Syndrome) Authors: Ceren BaƩal, Emmanuelle Bellot, Benoit Herman, Iqra Shahzad, Moritz Wurm, Olivier Collignon, Gilles Vannuscorps 9 – Can the dimensionality crossing phenomenon partly explain the large sex diﬀerence in the mental rotaƟon test? Authors: Daniela E. Aguilar Ramirez, Stephanie Chu, Claudia L. Gonzalez 10 – Reach adjustment and target selecƟon begin within 80ms Authors: David Y. Mekhaiel, Melvyn A. Goodale, Brian D. Corneil 11 – Comparing object topography in visual cortex and arƟﬁcial neural networks Authors: Davide CorƟnovis, Bracci Stefania 12 – Reward as a facet of word meaning Authors: Doina-Irina Giurgea, Penny M. Pexman, Richard J. Binney 13 – Distributed high-level processing supports the emoƟonal assessment of complex social scenes (human brain and AI) Authors: Elahe Yargholi, Laurent Mertens, Joost Vennekens, Jan Van den Stock, Hans Op de Beeck 14 – Changes in connecƟvity between ‘higher order’ perceptual areas in apraxia aŌer stroke Authors: Elisabeth Rounis Zuo Zhang, Ajay Halai, Gloria Pizzamiglio, MaƩ Lambon Ralph 15 – Localising touch on the hand: Revealing systemaƟc variaƟons in performance and context-dependent direcƟonal biases. Authors: Elsie Harvey Pearce, Ronan Timircan, MarƟn Weber, Kenneth Valyear 16 – InvesƟgaƟng the funcƟons underlying short-term memory conjuncƟve binding through the study of aphantasia Authors: Emma Delhaye, Pauline Fritz, CharloƩe MarƟal, ChrisƟne BasƟn 17 – TesƟng humans and machines on the animate-inanimate disƟncƟon for ambiguous visual objects Authors: Farzad Rostami-Ghahfarokhi, Céline Spriet, Hans Op De Beeck, Jean-Remy Hochmann, Liuba Papeo 18 – AƩenƟon to AcƟons Authors: Federica Danaj, Lena Gessele, Jens Schwarzbach, Paul Downing, Angelika Lingnau 19 – ConnecƟng the dots: similar visual reading acquisiƟon for Braille or line juncƟons Authors: Filippo Cerpelloni, Olivier Collignon, Hans Op de Beeck 20 – ReweighƟng of Visual Depth Cues through Dynamic InteracƟon with ConﬂicƟng SƟmuli Authors: Francesca Peveri, Andrea Canessa, Silvio P. SabaƟni 21 – Does unisensory object categorisaƟon improve following mulƟsensory category training? Authors: Grace A. Gabriel, Fiona N. Newell 22 – InteracƟons of Visual and Motor PlasƟcity in Adults Authors: Izel D. Sari, Claudia Lunghi 23 – A specialized mental resource for intuiƟve physics Authors: Jason Fischer, Alex Mitko 24 – Ultrafast RS fMRI unveils