U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov < Proportions of categories observed in LC and GC. GC workflow: Katherine Phillips, Alice Yau (Southwest Labs) LC workflow: Alex Chao, Jon Sobus, Barbara Wetmore Risa R. Sayre1,2, John F. Wambaugh1, Katherine Phillips3, Antony Williams1, Christopher M. Grulke1 1) U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, RTP NC 2) Oak Ridge Institute of Science and Education (ORISE) Research Participant 3) U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Computational Exposure Division, RTP NC 1) Background 2) Method: Categorizing chemical origin 5) Method: Supporting NTA identification 6) Discussion Risa R. Sayre l ORCID 0000-0002-6173-8020 l sayre.risa@epa.gov A public database supporting evidence-based exposomics To support identification of likely sources of chemicals found in biological media through non- targeted/suspect screening analysis (SSA/NTA), this work-in- progress annotates chemicals with likely origin categories and adds empirically-validated substance relationships between chemicals and their in vivo transformation products to the CompTox Chemicals Dashboard1. We identify five categories of chemical origin (based on Rappaport et al 20142) of small molecules found in human blood biomonitoring samples: 1) endogenous metabolome, 2a) exogenous nutrients, 2b) markers of exposure to exogenous nutrients, 3a) xenobiotics (pharmaceuticals, pesticides, and others), and 3b) markers of exposure to xenobiotics. 1) Williams AJ, et al. The CompTox Chemistry Dashboard: a community data resource for environmental chemistry. J Cheminform. 2017 Nov 28;9(1):61. 2) Rappaport SM, Barupal DK, Wishart D, Vineis P, Scalbert A. The Blood Exposome and Its Role in Discovering Causes of Disease. Environ Health Perspect. 2014 Aug; 122(8). 3) U.S. Food & Drug Administration. Substances Added to Food (formerly EAFUS). www.accessdata.fda.gov/scripts/fdcc/?set=FoodSubstances 4) U.S. EPA Office of Pesticide Programs. Pesticide Chemical Search. iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:1 5) U.S. EPA TSCA Chemical Substance Inventory. www.epa.gov/tsca-inventory/how-access-tsca-inventory 6) Sobus JR, et al. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA. J Expo Sci Environ Epidemiol. 2017 Dec 29. 7) Richard AM, Williams CR. Distributed structure-searchable toxicity (DSSTox) public database network: a proposal. Mutat Res. 2002 Jan 29;499(1):27-52. 8) U.S. EPA High Production Volume Information System. http://iaspub.epa.gov/oppthpv/hpv_hc_characterization.get_report?doctype=2 9) McEachran AD, Sobus JR, Williams AJ. Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard. Anal Bioanal Chem. 2017 Mar;409(7):1729-1735. This project was supported in part by an appointment to the Internship/Research Participation Program at the National Center for Computational Toxicology, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. 7) References Over 10,000 mappings of xenobiotic transformation relationships are being added to DSSTox, many of which are not currently registered in any metabolomics database. Developing methods to improve identification of these substances measured in human blood and their source categories supports active Agency research projects (e.g. for PFAS chemicals). Registration of xenobiotics and observed transformation products based on dose levels demonstrated to yield a detectable (by a known method) amount of product in a particular species and medium in a chemical library • allows development of exposure estimates • identifies candidate substances and pathways to inform future high- throughput assay research to identify


The older the diabetes, the less regular is the consultation in ophthalmology & One out of 4 diabetics will already have proliferative diabetic retinopathy at their ophthalmological consultation. Abstract citation ID: ckad160.1150 Increasing incidence of non-Hodgkin lymphoma in England, 1985–2019 Anjum Memon M Bawa1, Y Salari1, E Taylor-Gallardo1, A Memon1 1Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, UK Contact: a.memon@bsms.ac.uk Background: In the UK, non-Hodgkin lymphoma (NHL) is the most common hematological malignancy and 6th most common cancer overall - accounting for about 14,200 new cases and 4,900 deaths each year. After rising rapidly from the 1980s onwards, the incidence rates of NHL have broadly stabilised in several European and North American countries since the late 1990s. We conducted a retrospective population-based cohort study to examine whether similar changes in the incidence of NHL have also occurred in England from 1985-2019. Methods: Individual-level data for patients diagnosed with NHL, and the corresponding national population (denominator) data were obtained from ONS/PHE. Average annual incidence rates (AAIR) were calculated by sex, three age categories (0-34, 35- 64 and 65+ years) and seven five-year time periods (1985-89 to 2015-19). Results: During the 35-year study period, a total of 304,994 new cases of NHL were registered in England (54% males, 46% females). In young people aged 0-34 years, the AAIRs increased by 33% in males and 60% in females (from 1.8/100,000 in 1985-89 to 2.4/100,000 in 2015-19 in males, and from 1.0/100,000 in 1985-89 to 1.6/100,000 in 2015-19 in females). In middle age (35-64 years), the AAIRs increased by 54% in males and 57% in females (from 13.3 to 20.5 in males, and from 9.6 to 15.1 in females). At older ages (65+ years), the AAIRs increased by 108% in males and 102% in females (from 47.6 to 99.1 in males, and from 34.1 to 68.7 in females). In both sexes and all age categories, the disease was most frequently diagnosed at the advanced Stage 4. With regards to the socioeconomic status, the disease was relatively more commonly diagnosed in the most deprived groups. Conclusions: In contrast with many European and North American countries, there has been a steady and substantial increase in the incidence of NHL in England over the past four decades. Overall, the highest increase was observed in males (115%) and those aged 65+ years (109%). Key messages:  The reasons behind this continued increase in incidence in England, which is in contrast with most European/North American populations, remain elusive and need further etiological investigation.  Considering that the large majority of cases were diagnosed at the advanced Stage 4, there is an urgent need for clinical guidance to facilitate early diagnosis of NHL. Abstract citation ID: ckad160.1151 Suicidal ideation in coronary heart disease patients: the role of ethnicity and lifestyle factors Vladimı´ra Timkova´ V Timkova´ 1, A Husivargova1, L Kundratova1, I Nagyova1 1Department of Social and Behavioural Medicine, Faculty of Medicine, P.J. Safarik University in Kosice, Slovakia, Kosˇice, Slovakia Contact: vladimira.timkova@upjs.sk Background: Suicidal ideation (SI) is more prevalent in people with coronary heart disease (CHD) when compared to the general population. However, studies on protective factors against SI in people with cardiovascular diseases are still lacking. Moreover, there is less known about risk factors, such as ethnicity or lifestyle factors in SI and suicidal behavior. Thus, we aimed to examine the associations between ethnicity, lifestyle factors and SI in people with CHD when controlled for sociodemographic and clinical variables. Methods: We included 878 patients (60.0% male; 86.0% non-Roma; mean age 57.817.59 years; BMI 29.7810.39 kg/m2) with CHD. All participants completed the 36-Item Short Form Survey, Food Frequency Questionnaire, Physical Act


DIVERSIDAD DE MACROINVERTEBRADOS BENTÓNICOS EN ECORREGIONES DE ALTURA DE JUJUY (NORTE ARGENTINO) Vargas Rodríguez, Nelly Nicolaza María 2; Pereyra, Laura Cecilia 1 ; Torrejon, Silvia Elena 1,2 (1) Instituto de Ecorregiones Andinas (INECOA), CONICET, Universidad Nacional de Jujuy (Jujuy – Argentina) (2) Laboratorio de Limnología y Ecología Acuática, Cátedra de Ecología. Facultad de Ciencias Agrarias - Universidad Nacional de Jujuy. Correo electrónico: torrejonelena@gmail.com Los estudios de diversidad acuática plantean una declinación del número de taxones en relación al incremento altitudinal debido a la baja presión de oxígeno, descenso de las precipitaciones y la temperatura o a cierta homogeneidad del hábitat, entre otros. Estos trabajos se han realizado en un amplio gradiente que va desde pocos metros hasta las altas montañas. En las zonas de altura del Noroeste argentino (NOA), sobre los 3200 msnm, se han realizado algunos trabajos en humedales (vegas y ríos), generalmente a una escala local o en un hábitat particular, subestimando la gran heterogeneidad ambiental que caracteriza a estos ambientes a pesar del aspecto desértico e inhóspito de estas vastas extensiones. Determinar el patrón espacial de la diversidad de macroinvertebrados acuáticos en las ecorregiones de Puna y Altos Andes de la provincia de Jujuy, analizando los componentes alfa y beta de la diversidad de ensambles de invertebrados bentónicos entre distintas cuencas a una escala regional y considerando el aparente estrecho gradiente altitudinal (1000 m) entre sitios. OBJETIVOS INTRODUCCIÓN MATERIALES Y METODOS CONCLUSIONES A escala regional se reconocen los factores ambientales que actúan como un filtro de selección natural para las especies de la Puna y Altos Andes de la región NOA. Los grupos bioclimáticos agrupan a las cuencas en concordancia con la propuesta para la tipología bioclimática de la provincia de Jujuy (Entrocassi et al., 2014) Existe un gradiente altitudinal que aún en 1000 metros define patrones espaciales de distribución en ensambles de invertebrados bentónicos, donde se observa un incremento de la riqueza y la diversidad verdadera, con el incremento de la altitud. Los cambios en la diversidad se pueden observar a diferentes escalas, incluso cuando esta no presenta una gran amplitud. Contrariamente a lo esperado, los sitios más altos en la ecorregión de Altos Andes, presentan los mayores valores de riqueza y diversidad verdadera. RESULTADOS Se realizó un diseño a escala regional, con 19 sitios distribuidos en seis cuencas, para las ecorregiones de Puna (3200 – 4200) y Altos Andes (4500 – 4600 msnm) de la provincia de Jujuy, durante la primavera de 2015. Los sitios seleccionados representan la variedad de hábitats que se encuentran en esta región: ríos y arroyos con sedimentos finos o rocosos, aguas termales, arroyos de vegas o bofedales, vegetación sumergida y una amplitud de valores de conductividad. Las muestras se tomaron con red Surber modificada y se procesaron siguiendo la metodología estándar. Se realizó un análisis de cluster para clasificar los sitios en grupos con similitudes ambientales (temperatura media anual, precipitación media anual y altitud fueron significativos). Se comparó el resultado de los grupos bioclimáticos con la tipología bioclimática propuesta para la provincia de Jujuy (Entrocassi et al., 2014). Se comparó la diversidad alfa media entre los grupos bioclimáticos resultantes mediante un modelo lineal generalizado. Se utilizó el método de partición aditiva de la diversidad beta propuesto por Baselga (2010) y se obtuvo la diversidad beta total y sus componentes ( beta de anidamiento y beta de recambio de especies). Se revisaron 19 muestras donde se determinaron 45 taxones, contabilizando 63.260 individuos. Los sitios se ordenaron (Fig. 1) en 3 grupos bioclimáticos: 1) Río Grande – Yavi – Miraflores, 2) Olaroz – Tuzgle, y 3) Vilama, esta clasificación explica el 99 % de la variabilidad y define a la temperatura medi


OPEN ACCESS AN DER TECHNISCHEN UNIVERSITÄT BERLIN www.ub.tu-berlin.de/oa BY Lizenziert unter CC BY 4.0 | https://creativecommons.org/licenses/by/4.0 SERVICES DER BIBLIOTHEK BERATUNG Wir beraten Sie unter anderem zu • Rechten von Autorinnen und Autoren • Modellen des Open-Access-Publizierens • Möglichkeiten der Zweitveröffentlichung • Creative-Commons-Lizenzen Kontakt • openaccess@ub.tu-berlin.de • https://www.ub.tu-berlin.de/oa • https://blogs.ub.tu-berlin.de/openaccess ZWEITVERÖFFENTLICHUNGEN Viele Wege machen eine Open-Access- Zweitveröffentlichung möglich: • gesetzliches Zweitverwertungsrecht • allgemeine Richtlinien der Verlage • Sonderkonditionen für TU-Angehörige • individuelle Genehmigungen der Verlage Für TU-Angehörige prüfen wir auf Wunsch die rechtlichen Voraussetzungen und unterstützen bei der Veröffentlichung auf dem Open-Access- Repositorium der TU. HOSTING FÜR OA-ZEITSCHRIFTEN Unsere Angebote für TU-Angehörige, die selbst Open-Access-Zeitschriften gründen bzw. bestehende Zeitschriften in ein Open-Access-Modell überführen wollen: • Hosting auf der Basis der Publikationsplattform „Open Journal Systems“ (OJS) • Universitätsverlag berät und unterstützt für noch höhere Sichtbarkeit und Verbreitung der Inhalte WORKSHOPS Gern stellen wir das Themenfeld Open Access in Arbeitsgruppen oder Fachgebieten vor. Unsere Kernthemen sind • urheberrechtliche Grundlagen des wissenschaftlichen Publizierens • Open Access auf dem Goldenen und Grünen Weg • Creative-Commons-Lizenzen Bei Länge und inhaltlicher Ausrichtung richten wir uns nach den individuellen Bedürfnissen. Materialien früherer Open- Access-Workshops finden Sie im Slideshare-Konto der UB.


No 68 Attainment of Therapeutic Vancomycin Trough Serum Concentrations With Empiric Dosing In Neonates Lee Choy Ee, Suhaida Shukor, Sarah Diyana Shafie, Seah Yin Kuan Hospital Kajang NMRR-17-3080-39364 INTRODUCTION Vancomycin is commonly used to treat neonatal late-onset sepsis. It is the first-line antibiotic for treatment of infections caused by coagulase-negative staphylococci (CoNS) and methicillin-resistant Staphylococcus aureus (MRSA). However, data for dosing and monitoring of vancomycin in the local neonatal population is lacking. This study aimed to assess the percentage of neonates achieving a serum trough concentration between 10 to 20 mcg/mL with empiric vancomycin dosing. MATERIALS AND METHODS RESULTS • Of the 51 patients included, only 41% achieved target trough with empiric dosing. 22% of trough concentrations were sub-therapeutic whereas 37% were supra-therapeutic. • The mean GA was 31.8 weeks whereas mean PMA was 35.3 weeks. • On average, patients were started on vancomycin at weight of 1922.5 grams for 6.7 days. • All the supra-therapeutic trough concentrations were from the preterm group when compared to term neonates (45.2% vs 0%, p <0.05). • From this preterm group, 73% were contributed by the very preterm neonates (GA<32 weeks). The percentage decreased when gestational age increased. Similar trend of distribution was also observed in PMA category. • The occurrence of nephrotoxicity is low with only one incidence reported (defined as a doubling of serum creatinine from baseline). DISCUSSION/ CONCLUSION • Our study revealed that higher percentage of trough concentrations were supra-therapeutic (37%) compared to sub-therapeutic concentrations (22%). This was in contrary to studies conducted by Ringenberg et al. and Vandendriessche et al. which reported higher proportion of sub-therapeutic trough concentrations, 71.9% and 76.2% respectively1,2. Both were using Neofax® as dosing regimen. • This could be explained by the significant reduction of clearance in premature neonates due to diminished glomerular filtration rate in early days of life. There is marked increase in renal function which occurs over the first few weeks of life3. • We found that our premature neonatal population required lower dosages than the current recommendation. A local study conducted by Lo et al showed that the clearance of vancomycin was lower than that estimated in the Caucasian patients. Hence, it is important to consider the pharmacokinetic variability among these population4. • In conclusion, our preterm neonatal population experienced much higher occurrence of supra- therapeutic trough levels. Further studies are required to evaluate the optimal dosing regimen to achieve therapeutic trough concentrations in this patient population. Figure 1: Percentage attainment of vancomycin trough concentrations and distribution according to GA and PMA. GA= gestational age; PMA= postmenstrual age; w= week REFERENCES 1. Ringenberg T, Robinson C, Meyers R, Degnan L, Shah P, Siu A, et al. Achievement of Therapeutic Vancomycin Trough Serum Concentrations with Empiric Dosing in Neonatal Intensive Care Unit Patients. Pediatr Infect Dis J. 2015 Jul;34(7):742–7. 2. Vandendriessche A, Allegaert K, Cossey V, Naulaers G, Saegeman V, Smits A. Prospective validation of neonatal vancomycin dosing regimens is urgently needed. Curr Ther Res. 2014;76:51–7. 3. Leroux S, Jacqz-Aigrain E, Biran V, Lopez E, Madeleneau D, Wallon C, et al. Clinical utility and safety of a model-based patient- tailored dose of vancomycin in neonates. Antimicrob Agents Chemother. 2016;60(4):2039–42. 4. Lo YL, Van Hasselt JGC, Heng SC, Lim CT, Lee TC, Charles BG. Population pharmacokinetics of vancomycin in premature malaysian neonates: Identification of predictors for dosing determination. Antimicrob Agents Chemother. 2010;54(6):2626–32. GA<32w GA≥32w PMA <37w PMA ≥37w <10 mcg/mL 10–20 mcg/mL >20 mcg/mL


OSSDIP: Open Source Secure Data Infrastructure and Processes Platform that Supports Data Visiting Martin Weise 1 Tobias Grantner 1 Lukas Mahler 1 Andreas Rauber 1 Problem Description In an increasing number of settings, both researchers in academia as well as stakeholders in industry need to safe- guard access to highly sensitive data. Analyst-VM (Compute) Desktop-VM (Access) Owner-VM (Ingest) Data Owner Analyst want share data want access data provide data work requires Figure 1: Social architecture (highlight) While data sharing is being proclaimed as the future in open science, many settings do not allow for such ap- proaches due to e.g. confidentiality concerns. Methodology Based on the UK HDRA Trusted Research Environments (TRE) definition and experience of operating DEXHELPP for almost ten years. Provide highly controlled and moni- tored data visiting services, without disseminating an ac- tual copy: • Components of data anonymization and fingerprinting • Extensive logging and monitoring • Defined processes and contractual frameworks Secure Data Infrastructure The overall concept is centered around the principle of never providing access to the data node where all data is being held. For each individual analysis request: • Specific subset of the data required is extracted from the data node, and • Copied onto a dedicated Analyst-VM, together with the tools required to perform the analysis Proposal RQs, Tools, etc. Desktop-VM (Access) Proposal RQs, Tools, etc. Monitoring Logs, etc. Analyst-VM (Compute) Subset RStudio (Data Science) KNIME (Analytics) Data Node (Sensitive Data) Jupyter (Data Science) Figure 2: Data access workflow (highlight) Access to this Analyst-VM is granted to the analyst working on the task at hand – however, never directly, but only via a dedicated Remote Desktop-VM to introduce a media break and avoid any data flowing off via e.g. a tunnel. Research Activities via Data Visiting A dedicated Remote Desktop-VM is created to provide the sole access to the Analyst-VM. The Analyst then can ana- lyze the data as long as the time-out is not reached. Figure 3: Working with the raw data in Jupyter, RStudio and KNIME Our reference implementation supports open-source tools by default: • Data science: Jupyter Notebooks, RStudio, KNIME • Text processing: Libreoffice, LATEX • Programming: Python, Java, R It can be extended to support commercial software as well in the configuration files Conclusions The current state of the secure data infrastructure allows a Data Owner to invite experts (e.g. Analyst) to visit sensi- tive data on a trusted meeting point (Analyst-VM). OSS- DIP requires at least three (optimally nine) physical ma- chines on trusted hardware. Contact Technical lead Projektass. Dipl.-Ing. Martin Weise looks forward for your e-mail: martin.weise@tuwien.ac.at References [1] Project Website. https://ossdip.at/. [2] M. Weise, F. Kovacevic, N. Popper, and A. Rauber. OSS- DIP: Open Source Secure Data Infrastructure and Pro- cesses Supporting Data Visiting. Data Science Journal, 21:4, 2022. doi:10.5334/dsj-2022-004. [3] M. Weise and A. Rauber. A Data-Visiting Infrastruc- ture for Providing Access to Preserved Databases that Cannot be Shared or Made Publicly Accessible. In Pro- ceedings of the 17th International Conference on Digital Preservation, 2021. doi:10.17605/OSF.IO/VKN4R. 1Vienna University of Technology


20 Ed Baker1,2, Ben W. Price1 1Department of Life Sciences, Natural History Museum, London, SW7 5BD, UK 2Department of Electronic Engineering, University of York, York, Introduction The Natural History Museum (London) collection of recorded wildlife sound comprises mainly of field and laboratory recordings made between the 1970s and 1990s by David Ragge and Jim Reyn olds. The recordings underpin historic acoustic studies on the European Orthoptera (e.g. Ragge & Reynolds, 1998) and the taxonomy of the frogs of Mulu National Park (e.g. Dring, 1984). Where possible BioAcoustica makes links between sound recordings and preserved specimens, and the collecting of appropriate voucher specimens is encouraged for those submitting recordings. The majority of specimens for which recordings are held (including a number of holotypes) are depos ited in the Natural History Museum, London. Depositing specimens in other collections is also en couraged, and several projects will also be depositing material in the National Museums of Scotland, Edinburgh. Linking recordings to published works is also facilitated, allowing the recordings that underpin re search to be easily identified and faciliating reproducability in bioacoustic research. A description of the project canbe found in Baker et al (2015). Current Work The value of sound recordings in taxonomy is highlighted by the recent description (Heller & Baker, 2017) of a new species of the Orthopteran genus Horatosphaga that was initially uncovered by an unusual sound recording that did not match other members of the genus. The linkage of sound re cordings to museum specimens allowed the status of the new species to be confirmed. Several publications (e.g. Marshall et al, 2016) have specified BioAcoustica as a repository for sound recordings underpinning research findings, and others (e.g. Milach et al, 2015) have contributed re cordings that are linked to publictions after the original publication. Future Plans Recordings in BioAcoustica underpin the Leverhulme Trust funded Automated Acoustic Observa tories project. This project aims to use a new supertree of Orthoptera, bioacoustic analysis, and oth er trait data to create a step change in acoustic monitoring of species. References Baker E, Price BW, Rycroft SD, Hill J, Smith VS. 2015. BioAcoustica: a free and open repository and analysis platform for bio acoustics. Database 2015:bav054. Dring JC. 1984. Some new frogs from Sarawak. Amphibia-Reptilia 4(2):103 - 115. Heller K-G, Baker E. 2017. From an old sound recording to a new species in the genus Horatosphaga (Orthoptera: Tettigo nioidea: Phaneropterinae: Acrometopini). Zootaxa 4323(3):430-434. Marshall DC, Hill KBR, Moulds M, et al. 2016. Inflation of Molecular Clock Rates and Dates: Molecular Phylogenetics, Bio geography, and Diversification of a Global Cicada Radiation from Australasia (Hemiptera: Cicadidae: Cicadettini). System atic Biology 65(1):16-34. Milach EM, Martins L de P, Da Costa MKM, et al. (2015) A new species of tree crickets Oecanthus (Orthoptera, Gryllidae, Oecanthinae) in tobacco plantation from Southern Brazil, with body color variation. Zootaxa 4018(2):266. Ragge DR, Reynolds WJ. 1998. The Songs of the Grasshoppers and Crickets of Western Europe. Colchester, Essex: Harley Books; Horatosphaga raggei Heller & Baker, 2017: a new species of bush cricket first discovered from a sound recording on BioAcoustica Data linkages in BioAcoustica An online annotation tool allows for sections of voice introduction (blue), extraneous noise (red) and clear calls (green) to be identified, facilitating automatic analysis. Recordings linked to a publication (Marshall et al, 2016) on BioAcoustica.


10 12 14 16 18 20 0 40 80 120 160 t-Butanol/O2/N2, =1.0, PC = 15 bar 800 K 811 K 822 K 828 K 838 K 853 K Non- Reactive Pressure, bar Time, ms TC Validation of Kinetic Models of the Butanol Isomers at High Pressure using a Rapid Compression Machine Bryan W. Weber*, Chih-Jen Sung Department of Mechanical Engineering University of Connecticut Storrs, CT, 06269, USA Introduction and Objectives: Rapid Compression Machine: • Single, retractable, piston • Piston is pneumatically driven and hydraulically stopped • Piston is machined with crevices to control the roll-up vortex effect • Pressure and temperature from TDC reported as compressed conditions • The RCM has the ability to vary compressed temperature and compressed pressure independently • Compressed Temperature Range: 680-860 K • Compressed Pressure Range: 15 and 30 bar • Equivalence Ratio: 𝜙= 1.0, 𝑂2: 𝑁2 = 1 ∶3.76 Experimental Conditions: Experimental Analysis: • Ignition is defined by the local maximum of the time derivative of the post-compression pressure • Compressed temperature is computed using a non-reactive run, where oxygen in the mixture is replaced by nitrogen to eliminate reactions while maintaining a similar specific heat ratio Modeling Results: References: [1] Hansen, N., Harper, M.R., and Green, W.H., 7th US National Combustion Meeting, Georgia Institute of Technology, Atlanta, GA, March 20-23, 2011, paper 1B09 [2] Weber, B.W., Kumar, K., Zhang, Y., and Sung, C.J., Combustion and Flame, Volume 158, Issue 5, Pages 809- 819 doi:10.1016/j.combustflame.2011.02.005 [3] Weber, B.W. and Sung, C.J., 7th US National Combustion Meeting, Georgia Institute of Technology, Atlanta, GA, March 20-23, 2011, paper RK13 * bryan.weber@uconn.edu • Energy security and climate change are driving development of fuels from many new sources, particularly renewable bio-sources • Accurate kinetic models are required to enable design of new engine technologies to optimize operation towards emerging non-petroleum derived fuels • The butanol system is the smallest system with primary, secondary, and tertiary alcohols groups • Goal is to provide validation data using a heated rapid compression machine (RCM) at high pressures and low to intermediate temperatures Acknowledgements: This material is based upon work supported as part of the Combustion Energy Frontier Research Center, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Award Number DE-SC0001198 0 10 20 30 40 0 20 40 60 s-Butanol/O2/N2, =1.0, PC=15 bar, TC=827 K P(t), bar P'(t), bar/ms P(t), Non-Reactive Pressure, bar Time Derivative of Pressure, bar/ms Time, ms Ignition Delay,  End of Compression Maximum of P'(t) P'(t) P(t) -10 P(t), Non-Reactive 10 100 1.15 1.2 1.25 1.3 1.35 1.4 Butanol/O2/N2, PC = 15 bar,  = 1.0 s-Butanol i-Butanol n-Butanol t-Butanol Ignition Delay, ms 1000/TC, 1/K O2 : N2 = 1 : 3.76 10 100 1.15 1.2 1.25 1.3 1.35 1.4 1.45 1.5 Butanol/O2/N2, PC = 30 bar,  = 1.0 n-Butanol s-Butanol t-Butanol i-Butanol Ignition Delay, ms 1000/TC, 1/K O2 : N2 = 1 : 3.76 Experimental Results: • Arrhenius plots of the ignition delay show a clear dependence on compressed pressure • The order of reactivity of the isomers changes at higher pressure, from 𝑛−BuOH > 𝑠−BuOH ≈𝑖−BuOH > 𝑡−BuOH at 15 bar to 𝑛−BuOH > 𝑡−BuOH > 𝑠−BuOH > 𝑖−BuOH at 30 bar • There does not appear to be a negative temperature dependence region in these data • Pressure traces from the RCM do not show two-stage ignition for any of the isomers, in either pressure range • However, there is significant pre-ignition heat release for 𝑡−butanol and 𝑛−butanol, but not as much for the other isomers • Constant volume, adiabatic simulations were performed using one recent mechanism from Hansen et al.1 • Simulations do not capture the pressure dependence of 𝑛−butanol ignition delays, under predicting at lower pressure and over predicting at higher pressure • The deviations from experiments for 𝑖−


Stone inscriptions represent irreplaceable sources of information on the ancient world, as they are often the only textual evidence preserved from the past. This is surely linked to the high durability of the stone support, which survived the test of time, although often fragmentary or corroded. It appears nevertheless that the support has been disregarded and not included in the historical interpretation of such texts. Within the ERC funded project "CROSSREADS - Text, materiality and multiculturalism at the crossroads of the ancient Mediterranean", inscriptions from Ancient Sicily are also considered from the materials point of view. Non-invasive approaches for the screening of stone supports in Sicilian epigraphy Alessia Coccato1, Germana Barone2, Paolo Mazzoleni2, Jonathan Prag1 1Faculty of Classics, University of Oxford, United Kingdom 2University of Catania, Department of Biological, Geological and Environmental Sciences, University of Catania Introduction and aims This research is supported by the ERC-funded project "CROSSREADS - Text, materiality and multiculturalism at the crossroads of the ancient Mediterranean" (Grant agreement No. 885040). The authors thank the director of the Salinas museum, C. Greco, and the staff of the museum, especially S. Ruvituso for supporting the ongoing research. In order to assess the provenance of the used lithotypes, a multi-level approach has been devised. A first screening is carried out completely non-invasively in situ by means of portable X-rays fluorescence (pXRF) and digital microscopy with infrared, visible and ultraviolet light sources, at different magnifications. The systematic acquisition of chemical data and micro-photographs is accompanied by a limited sampling on a selected set of objects, in order to perform the traditional minero-petrographic thin-section observations, additional laboratory tests (X-rays diffraction, vibrational spectroscopies), and in the case of crystalline marbles, also isotopic analyses. Methodological approach The acquisition of extensive chemical datasets, as well as of microscopic images on the inscriptions (without taking a sample) is a challenging task in itself. The data processing of the numerous pXRF spectra that are currently being acquired on inscriptions on different materials across Sicily leads to multiple options for data interpretation: semi-quantitative data (major and trace elements) will be treated with well-established multivariate analyses to evaluate chemical differences and for comparisons with reference materials. Moreover, these approaches are also being tested on the raw spectra and will be compared with the results of compositional analyses. On the other hand, the petrographic information obtainable non-invasively with DinoLite will be compared with that from thin sections (on selected samples), in order to establish their usefulness in the characterisation of both Sicilian and exotic lithotypes. conclusions and perspectives X-rays fluorescence Digital microscopy A Bruker Tracer IV-SD is used with two different settings for 60s livetime acquisitions: • 15kV, 35A, with vacuum for major elements; • 40kV, 17A for the traces. For each stone, at least 3 measurements are acquired with each setting. Adapted configuration files are created for semi- quantification in PyMCA. The Spectroscopy package of Orange Data Mining is used for multivariate analyses of the spectra. A DinoLite AM7915MZTL digital microscope with 8 adjustable white LEDs is used. Images are acquired on well-preserved surfaces of inscriptions on display, and with consistent magnifications (ca. 30-35× and 70×). Additionally, a separate set of images with 100× magnification has been moreover acquired in the laboratory on the bulk samples, for further comparisons with the conventional thin sections. It appears that both local and imported stones were used in Sicily for different types of inscriptions (public works and accounts, religious dedications, funerary texts,


BACKGROUND The fungi, Metarhizium spp., are well known as pathogens of CRB (Oryctes rhinoceros), but natural infection in the field is relatively low. Infection levels can be increased by the application of laboratory- produced Metarhizium spores into breeding sites. Artificial breeding sites (ABS) can be constructed from decomposing palm logs and associated plant waste and treated with fungus. Female CRB are attracted to the decomposing material to lay eggs, commercial aggregation pheromones can be used to increase attraction. Immature stages of CRB will become infected and die, but infected emerging adults will spread the fungus. In this study, a locally isolated strain of Metarhizium majus was tested by applying to ABS. The impact of the application on CRB population and fungus dispersal was determined. METHODS • Isolate F717 (S4) isolated from one adult CRB cadaver found in an oil palm plantation at Tetere, Guadalcanal. • Conidia production Conidia were produced on rice grains (Figure 1) using solid fermentation (Nelson and Glare 1996). • Field trial M. majus was tested by applying nil, low (100g/ABS), moderate (200g/ABS) and high (400g/ABS) doses of sporulated rice (Figure 1) to four 2 x 2m ABS arranged in a grid (Figure 2). 50 CRB larvae were added to each ABS. This design was repeated at three oil palm blocks in Guadalcanal (Solomon Islands): Tetere, Mberande and Nekama. CRB numbers (adults and larvae) inside the ABS were assessed every 2 months for 6 months. Before applying the fungus, soil samples were taken at 10m, 50m and 100m from each ABS. The soil samples were ‘baited' with CRB larvae to detect Metarhizium sp. Soil baiting was repeated at 2-monthly intervals. DISCUSSION Results showed that isolate F717 (S4) is pathogenic to CRB larvae and adults in the ABS. Soil baiting showed that M. majus spread up to 100m from treated ABS and persist for at least 6 months at some sites. M. majus may contribute to CRB control if high levels of inoculum can persist in breeding sites under field conditions. Paul Gende1, Simon Chris1, Sean Marshall2, Sarah Mansfield2, Trevor Jackson2, Laura Villamizar 2 1Papua New Guinea Oil Palm Research Association, New Britain Palm Oil, Guadalcanal Plains, Honiara, Solomon Islands 2AgResearch Ltd. Lincoln Research Centre, Christchurch, New Zealand Address for correspondence: laura.villamizar@agresearch.co.nz Performance of Metarhizium majus applied in artificial breeding sites to control larvae of coconut rhinoceros beetle (CRB) in Solomon Islands Metarhizium majus applied as sporulated rice in artificial breeding sites can spread from the treated area and persist in the field for up to 6 months RESULTS Less than 32 CRB larvae/ABS were found during the 2-monthly evaluations at Tetere and Mberande. At Nekama, between 48 and 62 CRB larvae were found in the ABS from the control treatment after 2 and 6 months while less than 35 CRB larvae were found in fungus- applied ABS at all evaluation times. CRB cadavers showing green sporulation consistent with infection by M. majus were found inside ABS and pheromone traps. Metarhizium sp. was detected in Tetere soil samples from all distances/treatments before and after the inoculation of the ABS (Figure 3), suggesting the fungus was already established in this block after a commercial product with M. majus was applied in 2017. In contrast, Metarhizium sp. was not detected in soil samples collected from Mberande and Nekama before ABS inoculation, but the fungus was detected later in soil samples from all treatments, even at 100m away from the site. Figure 1. CRB larva infected with M. majus (A), M. majus grown on agar (B) and rice (C) A A B C Figure 3. Detection of M. majus spread from the ABS using the soil baiting method Control Low rate Medium rate High rate Figure 2. Experimental plot design for assessment of M. majus performance in ABS under field conditions Artificial Breeding Sites (ABS) Pheromone traps Sampling points


API Chiara De Bastiani - chiara.debastiani@unive.it Giulia Fabbris - giulia.fabbris@unive.it


References [1]Sherry,Justine,etal."Blindbox:Deeppacketinspectionoverencryptedtraffic."ACMSIGCOMMComputerCommunicationReview45.4(2015):213-226. [2]Symantec’sEncryptedTrafficManagement(ETM).https://www.symantec.com/products/encrypted-traffic-management. [3]Conti,Mauro,etal."Analyzingandroidencryptednetworktraffictoidentifyuseractions."IEEETransactionsonInformationForensicsandSecurity11.1(2016):114-125. [4]Papadogiannaki,Eva,etal."OTTer:AScalableHigh-ResolutionEncryptedTrafficIdentificationEngine."InternationalSymposiumonResearchinAttacks,Intrusions,andDefenses.Springer,Cham,2018. [5]Cisco’sEncryptedTrafficAnalytics(ETA).https://www.cisco.com/c/en/us/solutions/enterprise-networks/enterprise-network-security/eta.html. [6]Rizzo,Luigi."Netmap:anovelframeworkforfastpacketI/O."21stUSENIXSecuritySymposium(USENIXSecurity12).2012. By 2019, 80% of all network traffic will be encrypted. Are we prepared for handling fully encrypted network traffic? 80% 2019 Encrypted Unencrypted 90% 2020 Encrypted Unencrypted 70% 2018 Encrypted Unencrypted High performance encrypted network traffic inspection using hardware accelerators Eva Papadogiannaki Giorgos Vasiliadis Sotiris Ioannidis FORTH-ICS FORTH-ICS FORTH-ICS This work has been partially supported by the European Commission under the Horizon 2020 Program through the I-BiDaaS project under Grant Agreement 780787. Example applications based on DPI Application domain Firewall, Antivirus Network security Intrusion detection and prevention system Network security Network usage characterization Network analytics Traffic monitoring and classification Network analytics Network optimization Network performance Use of GPUs • Thousands of cores • Highly parallelhardwarearchitecture • Low power consumption • Up to 11GBGDDR6memory • High memorybandwidth (upto 616GB/s) • Inexpensivecommodityhardware Background Internet traffic analysis is commonly based on techniques like deep packet inspection (DPI). The core of traditional DPI implementations is based on pattern matching, that enables searching for specific strings or regular expressions inside the packet content. With the widespread adoption of network encryption, DPI tools that rely on plain text pattern matching become less effective, demanding the development of more sophisticated techniques. Traditional DPI implementations can only extract very coarse grained information for themajority of such traffic. State of the art • Trafficdecryption andinspection • BlindBox [1],Symantec’sETM [2] • Could causeprivacy violations/ Expensiveprocessing • Traffic classification using ML techniques that examine accuracy focusing on packet metadata(e.g. packetsizes, timestamps,direction). • Contietal. [3] • Noreal implementation • Realimplementationof encryptednetworkinspectionsystemsusing packetmetadata. • OTTer [4],Cisco’sETA[5] • Proprietarysource code Our solution Motivation A framework that offers the functionality of a pattern matching engine tailored for packet metadata, such as packet sizes. This framework can be used to build different network related applications, such as firewalls, L7 filtering, or an Intrusion Detection System. The signatures are processed into an automaton. The generation of the automaton is based on the Aho- Corasick algorithm that offers simultaneous multi- pattern matching. The implementation of the automaton is DFA-based and refactored to search for integers. Why Aho-Corasick? • Preprocesses patterns to build a state machine • Simultaneousmultipattern searching • Processes theinputin asingle pass • Pattern searching can be transferred to GPU to achieve high throughput and real timeresults A high-level overview Packet processing and parallelization • Assign one network traffic flow to one thread • Packet batching to hide expensive transfers throughPCIe • Flow hashing to avoidpacketreordering • Filter outpacketretransmissions • Avoid costly packet copies and context switches with the netmap [6] module that operates in the user space (sing


Survey of pathotypes of Globodera pallida occurring in Europe Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 51 300 Picture 1 Picture 1 Picture 1 Goals Globodera pallida and G. rostochiensis represent a threat for potato growing countries and as such they are quarantine pests. Deployment of the H1 resistance gene has been highly effective in controlling G. rostochiensis. However, this has led to strong selection of G. pallida, which has subsequently increased in prevalence in potato fields. Different G. pallida pathotypes exist which differ in their ability to overcome various sources of resistance. The focus of this project is to gain insights into the distribution and occurrence of G. pallida pathotypes in Europe and to compare and align the standard test populations in European countries. Research consortium AU (DK), INIAV (PT), Fera Science Ltd (GB), SASA (GB), NAK (NL), UoC (PT) Contact information Project coordinator: Mogens Nicolaisen mn@agro.au.dk Key outputs and results A mini symposium will be organised at the end of the project. The event will allow to share the results and knowledge produced in the framework of the project with official laboratories and national authorities Objectives During the project, information will be shared in order to: • share information on the presence and distribution of G. pallida in the partner countries over time • use DNA markers for the molecular characterization of the collected material • improve knowledge on G. pallida collections across the partner countries and to collect reference material • compare the standard test populations in the partner countries for official resistance testing and determine how they differ in virulence 06/2021-05/2024


Methods Processing: Characterization: INFLUENCE OF THE VISCOSITY ON THE DEGRADATION DURING PROCESSING OF PETG CENTRE FOR POLYMERS AND MATERIAL TECHNOLOGIES (CPMT) Hannelore Ohnmacht, Lynn Trossaert, Mariya Edeleva, Dagmar R. D’hooge and Ludwig Cardon Introduction During processing, polymers are often subjected to high temperatures and high shear rates during the (long) residence times inside the machine. This can cause the material to degrade, leading to structural changes in the polymer chain and thus an overall change of material properties. The main sorts of degradation that occur for (co)polyesters include thermal, oxidative, and hydrolytic degradation, which can lead to discoloration due to functional groups formation, crosslinking, or chain scission. Chain scission, being the main degradation mechanism for PET, refers to the rupture of polymer chains and can be induced by the presence of oxygen, water, or high temperatures. It results in smaller polymer chains, leading to a decrease of molecular weight of the polymer and consequently deterioration of material properties. This contribution examines the influence of three different viscosity grades on the degradation during processing of PETG. By analyzing the inherent viscosity and melt flow index of the material before and after processing, changes in the flow behaviour can be determined. Materials • 1,4-cyclohexylene dimethanol-modified polyethylene terephtalate (PETG) = TPA + EG + CHDM (≤ 50%) • 3 viscosity grades: • Low Viscosity (LV) • Medium Viscosity (MV) • High Viscosity (HV) Results Determination of processing parameters: Filament extrusion + FFF Injection Moulding Conclusion • Higher processing temperature needed for the HV grade due to incomplete filling of the mould • MFI and IhV confirm that chain scission is the main degradation mechanism • For 3DP parts, stepwise increase in MFI after every processing step • ~ degradation for LV and MV grades after FFF and IM • HV IM grade higher degradation after IM shear causes mechanochemical chain scission + higher T and shear heating might cause additional thermal degradation Contact hannelore.ohnmacht@ugent.be www.ugent.be/ea/match/cpmt/en Universiteit Gent @ugent Ghent University Drying of the pellets 65°C – 6h as Tg = ±80°C 1. Filament extrusion Brabender 19 single screw 2. FFF Brabender 19 single screw Injection Moulding Engel e-victory 28T Melt flow index measurements: • MFI ~ 1/η and η ~ Mw • After every processing step (FE and FFF) stepwise MFI increase of ± 2 • ~ degradation for FFF + IM parts for LV and MV • HV parts underwent significant degradation during injection moulding Inherent viscosity measurements: • To evaluate the quality of the material • Losses between 0 - 5 % well dried and processed • IM HV grade, the IhV loss is 17% significant degradation confirm MFI results due to shear ( mechanochemical chain scission) + shear heating (thermal degradation) IM FFF Melt flow index (MFI) Davenport 10 ISO 1133-A (240°C – 2,16 kg) Inherent Viscosity (IhV) Viscotek Y501C differential viscometer


Analyse des Status Quo[1] Standortspezifische Bestands- und Bedarfserhebung[2] Identifikation FDM-bezogener Communities Strategie- entwicklung Governance- Modelle Selbstevaluation mit RISE-DE3: Feststellung des Ist-Zustands im FDM bzw. der Reifegrade der vier Einrichtungen Ermittlung der Anforderungen von Forschenden, EXCs, SFBs und anderen Verbundvorhaben Themen- und fachspezifische Workshops Empfehlungen für FDM-Services, -Tools und Infrastrukturen Evaluation verschiedener Governance- Modelle METHODEN UND MASSNAHMEN ZIELE Konzeptentwicklung zum bedarfsorientierten Aufbau übergreifend nutzbarer Kompetenz, Expertise und Ressourcen zum Handlungsfeld FDM für Forschende und Multiplikator*innen Auf- und Ausbau nachhaltiger, institutionsübergreifender FDM-Services WEB PUBLIKATIONEN Ariza de Schellenberger, A., Bobrov, E., Helbig, K., Jäckel, D., Kuberek, M., Orozco Prado, L.-S., Schlagberger, E. M., Söring, S., & Steinke, B. (2022). Bestands- und Bedarfserhebung zum Forschungsdatenmanagement an den BUA-Einrichtungen (Version 1). Zenodo. https://doi.org/10.5281/zenodo.7060446 Ariza de Schellenberger, Bobrov, E., Helbig, K., Jäckel, D., Kuberek, M., Orozco Prado, L.-S., Schlagberger, E. M., Söring, S., & Steinke, B.: Stärkung von FDM- Services im Verbund – Ergebnisse einer Bedarfserhebung, in Heuveline, Vincent, Bisheh, Nina und Kling, Philipp (Hrsg.): E-Science-Tage 2023: Empower Your Research – Preserve Your Data, Heidelberg: heiBOOKS, 2023, S. 270–275. https://doi.org/10.11588/heibooks.1288.c18087 Förderkennzeichen: 501_CRDMS Referenzen [1] Ariza de Schellenberger et al., 2023, DOI: 10.17192/bfdm.2023.1.8551 [2] Ariza de Schellenberger et al., 2022, DOI: 10.5281/zenodo.7060446 [3] ] Hartmann et al., 2019, DOI: 10.5281/zenodo.3585556 Auf- und Ausbau von FDM-Services in der Berlin University Alliance Concept Development for Collaborative Research Data Management Services (BUA-FDM) Collaboratively Advancing Research Data Support (CARDS) 03.2021 – 06.2023 05.2024 – 10.2026 FAIR-konformes Datenmanagement an den BUA-Einrichtungen Vereinfachte Planung und Durchführung forschungsdatenbasierter Vorhaben in Verbund- und/oder Projektkontexten der BUA Kompetenzausbau im Handlungsfeld FDM bei den Forschenden der BUA Breite Verankerung von FDM im Verbund BUA Customised Research Data Management Organiser (RDMO) (TU) Data Stewardship in Exzellenzclustern (Charité) FDM-Kompetenz- entwicklung (FU) BUA-spezifische Erweiterungen für RDMO; Erleichterung der DMP-Erstellung für BUA-Forschende Professionalisierung des Datenmanagements in Exzellenzclustern, Steigerung der Datenqualität und - nachnutzbarkeit Ausbau übergreifender, u.a. aggregierter FDM- Schulungs- und Trainingsangebote; Kooperationen mit regionalen und nationalen Initiativen KONTAKT bua-fdm@lists.fu-berlin.de https://www.berlin-university- alliance.de/commitments/sharing-resources/fdm Einsatz von elektronischen Laborbüchern (HU) Konzeption, Architektur- und Betriebsmodell für die BUA-übergreifende Einführung von ELN-Systemen ZIELE https://www.berlin-university-alliance.de/commitments/sharing-resources/fdm/


Teaching with eXtended Reality – Evaluating the MirageXR Authoring Tool What is this pilot about? Pilot 4 aims to accelerate the uptake of AR in e d u c a t i o n , by providing an authoring tool and learning management system to teachers. We believe that introduction at scale requires to put tailored authoring tools in the hands of teachers to support the production of bespoke AR learning experiences for the mainstream as well as for the Long Tail. The MirageXR platform is user-friendly and does not require any prior AR experience. Participation is on a voluntary basis, as a choice under free will. Target Group We are looking for teachers who: • • have a good level of English language (B2 in Reading and B1 in Writing + Speaking) • • are pre-service or in-service teachers • • are willing to participate • • have an AR-compatible iOS2 or Android3 phone or tablet The Outcome With this pilot study (ARETE Pilot 4), we seek to evaluate quantitatively and qualitatively, in which ways and how well our authoring toolkit supports teachers in designing XR learning experiences. ARETE PILOT 4


EmulsiﬁersfromNaturalResources: TheRoleof LecithininEmulsionFormationfromMolecular Dynamics Dinais Alvarez1, Deisy Giraldo2, Cristian Blanco2, Marianny Combariza2 and Aldo Combariza1 1Grupo Investigación Modelamiento Molecular y Simulación Computacional in silico, Departamento Biología y Química, Universidad de Sucre; 2Grupo Investigación Fisicoquímica Teórica y Experimental GIFTEX, Escuela de Química, Universidad Industrial de Santander, Colombia Motivation Molecular Dynamics simulations can be applied to the study of physico-chemical parameters as interfacial tension of emulsions, e. g., a water-in-oil interface.[1] • Amphiphilic compounds as lecithins, are used as emulsi- ﬁers • Lecithins are a mix of Phospholipids (PLs), Triacylglicery- des (TAGs), and others compounds a. Phosphatidylcholine (POPC) as the commonness in lecithins., b. Di-oleoyl-linoleoyl-glycerol OOL as TAG. Computational Approximation From ensembles (Eqn. 1) < V >= ZZ V (pN, rN)ρ(pN, rN)dpNdrN (1) Using forceﬁelds: Charmm 36 FF to model intramolecular inter- actions (Eqn. 5). V ( ˆR) = X bonds Kb(b −b0)2 + X angles Kθ(θ −θ0)2 (2) + X dihedrals X j Kϕj(1 + cos(njϕ −δj)) (3) + X non−bonded−pairs−ij εij[( Rmin,ij rij )12 −( Rmin,ij rij )6] (4) + X non−bonded−pairs−ij qiqj εDrij (5) Surface tension can be measured applying the Kirkwood-Buff ex- pression (Eqn. 6) γKB = L 2 ⟨P⊥−P∥⟩ (6) All minimization and production runs were carried up using the INKARI High Performance Computational Scientiﬁc Cluster lo- cated at the Universidad Nacional de San Agustín (UNSA), Are- quipa, Perú, which features a Silicon Graphics U-Racked Cluster with Head Node SGI 2x AMD-Opteron processors, twelve-core, 2.4 GHz, 64 GB of RAM memory DDR3 1600 MHz 4 Discs of 2TB SATA 7200 RPM, 12 Server Nodes (9x SGI), each Node server with 2 AMD Opteron twelve-core processors, 2.4GHz, 64 GB of RAM memory DDR3 1600 MHz 3 SATA 2TB Disks 7200 RPM. All simulations were set-up using the GROMACS V. 2019 Molecular Dynamics code. System Deﬁnition and Details Based on an emulsion model with 80:20 volume proportion (80 mL TAG and 20 mL water) we calculated the number of molecules. Compound %Vol Vol (mL) Molar mass (g/mol) # Moles Molecules Ratio Total TAG 80 80 885.000 8.28E-02 4.98E+22 1 100 a Water 20 20 18.0150 1.11E+00 6.67E+23 13.4 1337 Compound % Mass Mass (g) Molar mass (g/mol) # Moles Molecules Ratio Total PPL 20 20 760 2.63E-02 1.58E+22 3.18E-01 34 The Volume Guesser extension from Packmol ofﬁcial webpage was used to estimate the volume of the system considering a volume per molecule as a proportion of its molar mass. Compound Molecules Density (g / mL) Molar Mass (g / mol) System Volume (Å3) Box Sides (Å) Water 1340 0.999 18.015 40117.12 34.26 OOL 100 0.9156 885 160508.02 54.35 PPLb 34 0.917 760 44040.6 35.31 The estimated volume of each PPL, TAG and WATER interface in the Z dimension is shown. According to this proportions, Packmol software was used to construct and pack all interfaces. Phase/Compound Vol. Å3 Box of side Å Size on X Size on Y Size on Z. Water 40117.12 34.26 47 47 26 OOL 160508.02 54.35 47 47 67 PPL 44040.63 35.31 47 47 28 aDensity of TAG was obtained from experimental density value of sunﬂower oil. bDensity for PPL was obtained from experimental density of soybean oil Framework Simulations and Dynamics Cell with parameters: A, B and C = 6.04350, 5.94580, 15.97680, respectively and a cubic box with al- pha=beta=gamma=90, resulting in a box of 574,10 Å. Water phase with 1337 molecules 34 molecules of POPC with polar heads oriented towards the water OOL interface of 100 molecules interacting with the POPC tails POPC interface with 34 molecules Another water interface of 1337 molecules First step: Energy Minimization • Steepest descendent optimization for 50000 steps • Electrostatic interactions were established by the Particle Mesh Ewald PME algorithm with a cut-off of 1.2 and a Van der Waals cut-off distance of 1.2. • Periodic boundary conditions PBC were applied in all direction


Motivation ArXiv:1909.04044, Miguel Escudero[a] and Sam Witte[b] [a] King's College London, [b] Instituto de Física Corpuscular Conclusions and Outlook References [1] Riess et. al. 1903.07603. Astrophys. J. 876 (2019) 85. [2] Planck Collaboration, 2018 Cosmological Parameters, 1807.06209. [3] The Hubble Hunter's Guide, L. Knox and M. Millea, 1908.03663. [4] Y. Chikashige, R. N. Mohapatra & R. D. Peccei, Phys. Lett B98 (1981) 265-268. [5] Z. Chacko, L. J. Hall, T. Okui & S.J. Oliver, PRD 70 (2004) 085008, hep-ph/0312267. [6] M. Escudero, JCAP 1902 (2019) 007, 1812.05605, 2001.04466. [7] M. Escudero & S. J. Witte 1909.04044. Corresponding Author: miguel.escudero@kcl.ac.uk NuPhys2019: Prospects in Neutrino Physics (London) Could the Hubble Tension be Pointing Towards the Neutrino Mass Mechanism? m⌫6= 0 ⌫e ! ⌫µ ¯⌫ ⌫ φ H0 The Hubble Tension Neutrino Masses The Scenario Physics beyond ΛCDM? Physics beyond the SM 4.4σ discrepancy between the local determination of the Hubble constant [1] as measured using Cepheids and type-Ia SN to the value inferred from Planck CMB observations within ΛCDM [2]. Planck data has been exhaustively checked against systematics and CMB systematics cannot be responsible for the tension. Several groups have reanalysed the local measurements and so far there is no known systematic capable of substantially ameliorating the tension. Strong lensing measurements of H0 are in agreement with local determinations while Baryon Acoustic Oscillations agree with the CMB. Neutrinos oscillate and at least two of them have a mass. Neutrino masses are the only laboratory evidence of physics beyond the Standard Model, since mνSM = 0. Viable solutions to the tension require an enhanced expansion history close and prior to recombination. However, simply enhancing Neff does not work [2,3]. Furthermore, BBN constraints typically apply. The Majoron: a Neutrinophilic pseudo-Goldstone boson from the seesaw mechanism with Global Lepton number Neutrino masses via the type-I seesaw mechanism But heavy neutrino Majorana masses should come from somewhere. Here, via the spontaneous symmetry breaking of U(1)L. Majoron Properties Cosmological Implications Main Results If Lepton number is a global symmetry (as in the SM) then a physical pseudo-Goldstone boson appears in the spectrum: the Majoron [4]. Very feeble interactions with neutrinos λ ' 10−13 m⌫ 0.05 eV 1 TeV vL Extremely weak interactions with matter λφee ' 10−20 Gravity breaks all global symmetries. Dim-5 Planck suppressed operators: Lint = iλ φ ¯⌫γ5 ⌫ ¯⌫ ⌫ φ Performed a full MCMC ﬁt to Planck2018 data and found very strong constraints ⚑. Ruling out masses compatible with dim-5 Planck suppressed operators ⚑ and testing couplings as small as λ ~ 10-13 and scales of lepton number breaking up to 1 TeV. Γφ ≥H(T⌫= mφ/3) Neutrino-Majoron interactions lead to [5]: Non-standard expansion history between BBN and recombination. Erase of the Neutrino anisotropic stress. provided We account [7] for these effects by solving the background evolution using [6] and by implementing in the Boltzmann code CLASS the non- standard expansion history and the impact on the neutrino perturbations. λ ⌧1 equivalently λ > 4 ⇥10−12 r mφ 1 keV Impact on the CMB Γe↵= ✓ λ 4 ⇥10−12 ◆2 ✓1 keV mφ ◆ Non-standard expansion history Leads to a contribution of across wide regions of parameter space. ∆Ne↵' 0.11 Modiﬁcation to the neutrino perturbations Leads to a suppression of the neutrino anisotropic stress that has very important implications for the CMB spectra. ˙δ⌫φ = −4 3✓⌫φ −2 3 ˙h , ˙✓⌫φ = k2 ✓1 4δ⌫φ −σ⌫φ ◆ , ˙F⌫φ2 = 2 ˙σ⌫φ = 8 15✓⌫φ −3 5kF⌫φ 3 + 4 15 ˙h + 8 5 ˙⌘−2aΓσ⌫φ , ˙F⌫φ ` = k 2` + 1 ⇥ ` F⌫φ (`−1) −(` + 1)F⌫φ (`+1) ⇤ −aΓF⌫φ ` , ` ≥3 . Γ = Γφ 2 m2 φ T 2⌫ e µ⌫ T⌫K1 ✓mφ T⌫ ◆ Γφ ' λ2 16⇡mφ Since , the only relevant processes are Majoron decays and inverse neutrino decays: The Majoron leads to across wide regions of parameter space ⚑ and hence ameliorates the Hubble tension without suffering from BBN constraints


[1] Matteucci, F. 2008, in Massive Stars as Cosmic Engines, ed. F. Bresolin, P. A. Crowther, & J. Puls, Vol. 250, 391–400; [2] Hopkins, P. F., Kereš, D., Oñorbe, J., et al. 2014, MNRAS, 445, 581; [3] Garcia-Segura, G., Mac Low, M. M., & Langer, N. 1996, A&A, 305, 229; [4] Krause, M., Fierlinger, K., Diehl, R., et al. 2013, A&A, 550, A49; [5] Kudritzki, R.-P. & Puls, J. 2000, ARA&A, 38, 613; [6] Kudritzki, R. P., Bresolin, F., & Przybilla, N. 2003, ApJL, 582, L83; [7] Bromm, V., Kudritzki, R. P., & Loeb, A. 2001, ApJ, 552, 46; [8] Heckman, T. M., Borthakur, S., Overzier, R., et al. 2011, ApJ, 730, 5; [9] Belczynski, K., Holz, D. E., Bulik, T., & O’Shaughnessy, R. 2016, Nature, 534, 512; [10] Marchant, P., Langer, N., Podsiadlowski, P., Tauris, T. M., & Moriya, T. J. 2016, A&A, 588, A50; [11] Dalton, G., Trager, S., Abrams, D. C., et al. 2020, SPIE Conf. Ser., 11447, 1144714; [12] Jin, S., Trager, S. C., Dalton, G. B., et al. 2024a, MNRAS, 530, 2688; [13] Monguió M., et al., 2020, A&A, 638, A18; [14] Pantaleoni González, et al., in prep.; [15] Pantaleoni González, M., Maíz Apellániz, J., Barbá, R. H., & Reed, B. C. 2021, MNRAS, 504, 2968; [16] Bailer-Jones, C. A. L., Rybizki, J., Fouesneau, M., Demleitner, M., & Andrae, R. 2021, AJ, 161, 147; [17] Simón-Díaz, S., Pérez Prieto, J. A., Holgado, G., de Burgos, A., & Iacob Team. 2020, in XIV.0 Scientiﬁc Meeting (virtual) of the Spanish Astronomical Society, 187 An up-scaled endeavor for exploring OB stars in the Milky Way within the WEAVE-SCIP survey A. de Burgos(1,2), S. Simón-Díaz(1,2), J. Drew(3,4), M. Monguió(3,5), S. R. Berlanas(1,2), A. Herrero(1,2), the WEAVE-SCIP collaboration Context and motivation The study of massive OB stars signiﬁcantly contributes to our comprehension of galaxies [1,2]. Despite their importance, OB stars gather many open questions concerning both their evolution and physical properties that remain unanswered. In this context, the Milky Way is a perfectly suited laboratory to study them. Spectroscopic observations of statistically signiﬁcant samples of these stars are needed to address those questions. In this regard, the WEAVE-SCIP [11,12] Low-Resolution (LR; R=5000) survey aims at building the largest and most homogeneous spectroscopic sample of OB stars up to date, covering most of the Northern Galactic disk. (1) Instituto de Astrofísica de Canarias (Spain), (2) University of La Laguna (Spain), (3) University of Hertfordshire (U.K.), (4) University College London (U.K.), (5) Universitat de Barcelona (Spain), Ph.D. Student IAC Progenitors of gravitational wave emitters[9,10] Tracers of star-forming regions Feedback to the interstellar medium[3,4] Chemo- dynamical evolution of galaxies[1] Reionization of the Universe[7,8] Extragalactic tools[5,6] Building the catalog for the survey IPHAS (Hα, Sloan r, i) + UVEX (URGO, Sloan g, r) |b| < 5° and 29° < l < 215° Bad sources ❌ Saturated sources ❌ Missing photometry ❌ 10.0 < gUVEX < 17.5 ❌ Data retrieval from IGAPS[13] Initial ﬁlter U,g,r Selection ﬁlter Additional ﬁlters For each IGAPS ﬁeld, a U-g / g-r diagram with a U-band correction was initially used to select 54.000 sources earlier than B3V star. 2MASS J,H,K and Gaia DR3 were used to remove unwanted sources. Using ALS III and Gaia DR3 Additional ~4000 targets from the Alma Luminous Star III (ALS III)[14,15] of OBA-type stars were added. Gaia DR3 photometry and distances from Bailer-Jones et al. (2021)[16] were used to ﬁlter out ~25.000 sources located below the extinction line of a 7M⊙ star. Very different reddenings → The OB candidates of the WEAVE-SCIP LR survey ● Magnitudes: 10 < G [mag] < 16 ● Distances: 2000 < d [pc] < 8000 ● A total of 410 pointings distributed in the Galactic plane. ● A maximum of 150 ﬁbers per pointing. ● Different priorities are assigned based on the location of the targets in the different diagrams. ● About 5000 targets have the highest priority and they lie above the 15M⊙ extinction line. Conclusions The U-band correction The


Poster template by ResearchPosters.co.za Mode-cleaning in Non-Hermitian Fibers and Waveguides M. N. Akhter1, R. Herrero1, M. Botey1 and K. Staliunas1, 2 1Departament de Fisica, Universitat Politecnica de Catalunya (UPC), Rambla Sant Nebridi 22, 08222, Terrassa, • Barcelona, Catalonia, Spain 2Institucio Catalana de Recerca i Estudis Avancats (ICREA), Passeig Llus Companys 23, E-08010, Barcelona, Spain Abstract Motivation Non-Hermitian GRIN MMF GRIN MMF 𝜙index modulation gain/loss modulation core radius Unidirectionality (2+1)D Linear Schrödinger Equation [5] 𝜕𝐴 𝜕𝑧= 𝑖1 2 𝛻2𝐴−𝑖∆ 𝑟𝑐 2 (𝑥2+𝑦2)𝐴+ 𝑖𝒎𝒓𝒆𝒄𝒐𝒔𝒒𝒛+ 𝒊𝒎𝒊𝒎𝒄𝒐𝒔𝒒𝒛+ 𝝓𝑽(𝒙, 𝒚)𝐴 𝜙 index modulation gain/loss modulation index modulation • Non-Hermitian potential: index and gain /loss modulation • Unidirectional, asymmetric, mode coupling • 𝑽(𝒛) ∝𝒄𝒐𝒔𝒒𝒛−𝒊𝒔𝒊𝒏(𝒒𝒛) = 𝒆𝒙𝒑−𝒊𝒒𝒛 • Couples any mode 𝑘𝑧with 𝑘𝑧−𝑞only • Hermitian potential [4]: only index modulation • Bidirectional, symmetric, mode coupling 𝑽𝒛𝒄𝒐𝒔𝒒𝒛= 𝟏 𝟐{𝒆𝒙𝒑𝒊𝒒𝒛+ 𝒆𝒙𝒑−𝒊𝒒𝒛} • Couples any mode 𝑘𝑧with 𝑘𝑧+ 𝑞and 𝑘𝑧−𝑞 Results: Antisymmetrically modulated non-Hermitian potential Conclusions Non-Hermitian potential controls the mode dynamics in parabolic multimode waveguides. Depending on the spatial delay between the real and imaginary part, higher or lower order modes are favored. Mode cascading towards lower order modes leads to effective all-optical spatial mode-cleaning. Different geometries of the potential leads to different mode coupling in 2D case. 1. J. Medina Pardell, et al. Opt. Exp. 29, 23997-24009 (2021). 2. S. Benadouda Ivars, et al. Phys. Rev. A 105, 033510 (2022). 3. K. Krupa, et al. Nature Photon 11, 237–241 (2017). 4. C. Mas Arabí, et al. Phys. Rev. A 97, 023803 ( 2018). 5. M. N. Akhter et al. Phys. Rev. Lett. 131, 043604 (2023). References This Project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 861152. https://mefista.astonphotonics.uk/ [3]. 𝜕𝐴 𝜕𝑧= 𝑖𝑑𝛻2𝐴−𝑖𝑐𝑥2𝐴+ 𝑖𝒎𝒓𝒆𝒄𝒐𝒔𝒒𝒛+ 𝒊𝒎𝒊𝒎𝒄𝒐𝒔𝒒𝒛+ 𝝓 𝒙 𝒙𝟎 𝒆 −𝒙𝟐 𝒙𝟎 𝟐 𝐴 𝐴𝑥, 𝑧= ෍ 𝑛 𝑎𝑛𝐻𝑛𝑥𝑒−𝑖𝑛𝑞𝑧 ∂𝑎𝑚 ∂𝑧= 𝑎𝑚𝑖𝛽𝑚+ 𝑖𝑚𝑞+ 𝑖𝑚+𝐶𝑚+1,𝑚𝑎𝑚+1 + 𝑖𝑚−𝐶𝑚−1,𝑚𝑎𝑚−1 𝑖Δ𝑞1 𝑖𝑚+𝐶21 0 ⋯ 0 𝑖𝑚−𝐶12 𝑖Δ𝑞2 𝑖𝑚+𝐶32 ⋯ 0 0 𝑖𝑚−𝐶23 ⋱ ⋮ ⋮ ⋮ ⋮ ⋮ ⋱ 𝑖𝑚+𝐶𝑛,𝑛−1 0 0 ⋯ 𝑖𝑚−𝐶𝑛−1,𝑛 𝑖Δ𝑞𝑛 One dimensional waveguide Two dimensional fiber 𝐈 𝑽𝒙, 𝒚, 𝒛= 𝑽𝒛𝑽𝒙, 𝒚= 𝑽(𝒛) 𝒙 𝒓𝟎 𝒆 −𝒙𝟐+𝒚𝟐 𝒓𝟎 𝟐 𝐈𝐈 𝑽(𝒙, 𝒚, 𝒛) = 𝑽(𝒛) 𝒙+ 𝒚 𝒓𝟎 𝒆 −𝒙𝟐+𝒚𝟐 𝒓𝟎 𝟐 (1+1)D Linear Schrödinger Equation index modulation gain/loss modulation index modulation gain/loss modulation We propose an all-optical control of the mode dynamics in multimode waveguides, by simultaneous modulation of the refractive index and of the gain/loss coefficient. The induced unidirectional mode-coupling, yields to the enhancement or reduction of the excitation of higher order transverse modes, depending on the modulation parameters [1, 2]. In the latter case, the all-optical mode-cleaning is observed. We analytically predict the effect on a coupled mode theory for 1D waveguides, which is numerically proven solving the wave propagation equation. The proposal is generalized to the more involved case of 2D waveguides for different geometrics. Analytics Eigenmodes as a function of the spatial delay (𝝓) Numerical Maps in Parameter space One dimensional mode-cleaning Different geometries of the potential Δ𝑞𝑚= 𝛽𝑚+𝑚𝑞 𝑂𝐼𝑛= ׭ 𝐴× 𝐻𝑛𝑑𝑥 2 ׭ 𝐴2 𝑑𝑥× ׭ 𝐻𝑛2 𝑑𝑥 𝑚𝑟𝑒= 𝑚𝑖𝑚= 1.5 × 10−4, 𝜙= 𝜋, 𝑞= 0.9 Δ𝑘𝑧 𝐶𝑛𝑚= ׬ 𝐻𝑛𝐻𝑚 𝑥 𝑥0 𝑒 −𝑥2 𝑥02 𝑑𝑥.


Mesa OpenEye OpenBabel CDK UNM Division of Biocomputing public web applications: Computational tools for cheminformatics and molecular discovery Jeremy Yang, Division of Biocomputing, University of New Mexico, Albuqueruqe, New Mexico, USA ChemAxon US User Group Meeting, Boston, September 13-15, 2010 ● Public web applications ● To benefit and engage the scientific community ● Cheminformatics and biomolecular discovery ● http://pasilla.health.unm.edu ● Employs diverse set of commercial, open- source and community-based components ● Limited bandwidth; etiquette essential WWW reigns! Now superpowered. Over the roughly 15 year history of the world wide web (WWW) the prevalence and usefulness of web applications has increased continuously. The “Web OS” paradigm is increasingly a reality, given tools such as GoogleDocs and Microsoft Office Web Apps, web services and cloud computing. Although web apps are not new per se, greatly enhanced capabilities are available via web apps now due to continual and dramatic improvements in (1) network bandwidth, (2) processor power, (3) web software development methods and (4) online data resources. In short, each year we can in practice do things with web apps we could not the year prior. What has not changed is the primary motivation for adoption of web apps: Deploying functionality via web apps is efficient and reliable for users, developers and managers. In addition and importantly (and this has changed somewhat as web UIs have become more complex), by virtue of their common features, web apps are generally easy to use. Web apps in cheminformatics In cheminformatics, the emergence of high quality programming toolkits, both commercial and community-based, has facilitated web app development with highly diverse aims and methods. Major software providers such as Daylight, Accelrys, ChemAxon and Chemical Computing Group have embraced web technologies, understanding their advantages and broad appeal. Web apps can vary from large scale enterprise tools (e.g. database access) to special purpose rapid prototypes for researching new algorithms. Diverse areas of research have been addressed with web apps, from toxicology prediction to 3D macromolecular visualization to quantum chemistry. Science enabled via WWW Web apps can also amount to a sort of scientific publishing. Whereas a journal article on computational methodology can leave many questions, and just as a picture can be “worth 1000 words”, arguably a functioning program might be worth 1000 pictures. In addition, agencies funding public research (such as NIH), where outcomes include computational methodology, quite reasonably and wisely require that such methodology and software be disseminated in effective, extensible, sustainable ways. Web apps developed with modern software engineering standards can well achieve these goals. Recently our app smartsfilter was used for a tuberculosis study1. ChemTattoo: colorized commonalities4 UNM Division of Biocomputing The UNM Division of Biocomputing is a multi-disciplinary research group within the Dept. of Biochemistry and Molecular Biology, in the UNM School of Medicine. Research areas include drug discovery, drug informatics, cheminformatics, bioinformatics, machine learning, QSAR, lead and probe identification. A major effort of the group is providing biomolecular screening informatics support for the UNM Center for Molecular Discovery (UNMCMD), an NIH Roadmap Molecular Libraries Programming screening center. As with UNMCMD, a long-term collaboration with Givaudan Flavors S&T has involved web apps and contributed to their development. These activities, and various other projects with collaborators who are geographically diverse, have motivated extensive use of web apps. ●Tudor I. Oprea (chief) ●Cristian Bologa ●Stephen Mathias ●Jerome Abear ●Oleg Ursu ●Gergely Zahoransky-Kohalmi ●Jeremy Yang Division of Biocomputing Personnel: Rapid prototyping enables research For scientific research web apps provide


MTLH is AFPT‘s solution for fast and reliable tape laying processes. It was built specifically for reinforcing metal sheets, thermoplastic parts or producing composite laminates. It allows the flexibility to lay 2“ wide tapes or 3 x ½“ tapes, thus increasing productivity & quality. Multi Tape Laying Head (MTLH) Technical Features • Flexibility in tape width and number of tapes • Individual control of multiple tapes • Usage of diode laser or VCSEL • Integration on industrial robot or CNC/gantry control of choice Sectorial Applications Sheet production or local reinforcement in: • Hybrid structures (metal reinforcement) • Preform or laminate production • Reinforcement of injection molded parts www.communionproject.eu FOR MORE INFORMATION CONTACT US: AFPT GmbH sales@afpt.de; www.afpt.de +49 6747 950 185 0 Trinkbornstraße 10 56281 Dörth, Germany This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 680567. The dissemination of results herein reflects only the author’s view and the Commission is not responsible for any use that may be made of the information it contains


Daniele Finazzia,b, Ruben Sevenoisa,b, Wim Van Paepegema a Department of Materials, Textiles and Chemical Engineering, Ghent University, Technologiepark 46, 9052 Zwijnaarde, Belgium b SIM M3 Program, Technologiepark 48, 9052 Zwijnaarde, Belgium The partners of ProPeL M3 research project, coordinated by Siemens (Siemens Digital Industries Software, Belgium), gratefully acknowledge the support of SIM (Strategic Initiative Materials in Flanders) and VLAIO (Flemish government agency Flanders Innovation & Entrepreneurship). ProPeL – PROCESS AND PERFORMANCE SIMULATION OF LIGHTWEIGHT STRUCTURES M3-Project Characterisation of short fibre composites for automotive applications injection THERMAL + MECHANICAL LOADS (proximity to engine, exhaust,…) SHELL SHELL CORE 200 µm “sandwich” microstructure: - SHELL (~90%): fibres aligned with injection direction - CORE (~10%): fibres at ~90° to injection direction MATERIAL APPLICATION Short fibre Glass/PA6 (injection moulding) Automotive parts SYNC CALIB. digital image correlation (DIC) infrared (IR) Self-heating in pure PA6? Self-heating in Glass/PA6? RESEARCH QUESTIONS METHOD (LOCAL) PLASTIC DEFORMATION (LOCAL) DEFORMATION RATE SELF- HEATING 𝜀 ሶ𝜀 𝑇 ሶ𝜀≥ሶ𝜀𝑐𝑟𝑖𝑡 Full-field strain and temperature measurements Strain Strain rate Temperature Tensile tests at room temperature 1. 2. Thermomechanical coupling CHALLENGES Thermoplastic PA6 matrix ENVIRONMENTAL CONDITIONS (temperature, humidity) PLASTIC DEFORMATION HEAT GENERATION ⇒ HEAT GENERATION RATE HEAT LOSS RATE SELF- HEATING ⇒ > 1.E+02 1.E+03 1.E+04 -100 -50 0 50 100 150 200 Temperature Modulus [MPa] 𝑇𝑔 ⇕ 0.36 mm/min ⇕ 36 mm/min ⇕ 360 mm/min x 𝑇 𝜀 ሶ𝜀 humidity decreases transition temperature temperature decreases properties x y z ⇕ 360 mm/min Effect of test speed (same displacement = 52.4 mm) PA6 (50%RH) GLASS/PA6 (50%RH) • Limited, local plastic deformation • Strain rate field not homogeneous • Negligible self-heating, regardless of test speed main fibre orientation thickness cross-section 𝜀 ሶ𝜀 𝑇 • Strain rate field not homogeneous • Temperature field matches strain rate field • Self-heating depending on test speed ⇕ 36 mm/min 90° x ⇕ 0.36 mm/min ⇕ 36 mm/min ⇕ 360 mm/min max +1°C max +4°C max +2°C Effect of test speed (frame before breakage) α 90° 45° 0° PA6 (unfilled) PA6 (unfilled) Polymer matrix composites have been used extensively in the automotive industry, thanks to a unique combination of high performance and light weight. Thermoplastic composites offer advantages in terms of recyclability and cost reduction compared to traditional thermoset composites. However, they are more sensitive to operating conditions. Understanding their coupled thermo-mechanical behaviour is essential to exploiting the full range of applications. I will be happy to discuss with you! Questions? Daniele.Finazzi@ugent.be Daniele Finazzi Test specimens


Data Output Type 1_Experimental Level. Each evaluation question will have ONE response per experiment, making a fixed total of questions equivilant to the number experiments Category Study Quality Evaluation Question Evaluation Result Test compound and controls Is the chemical name, ID, or CAS number of the test compound (s) provided? Fulfilled Test compound and controls Is the purity of the test compound stated or able to be determind by the information provided? Fulfilled Test compound and controls Is the solubility of test chemicals in the assay system described? Fulfilled Test compound and controls Negative, untreated or vehicle control was included? Fulfilled Test compound and controls Concentration of vehicle was provided? Fulfilled Test compound and controls It was stated that a reference compound or positive control was included? Fulfilled Test compound and controls Information on assay reagents (Product name, supplier and lot) was provided? Fulfilled Total 7 Test System The tests and/or methods used were sufficiently described to allow for evaluation of reliability of results? Fulfilled Test System Conditions (Inclubation temperature, humidity, CO2 concentration, etc.) was described? Fulfilled Test System The androgen receptor source and characteristics(recombinant, native, etc. was described? Not fulfilled Test System The cell system was described? Fulfilled Test System The number of cell passages for the cell line used and the number of cells (density) used during the treatment was described? Not fulfilled Test System The composition of media (use of serum, antibiotics, etc.) was described? Fulfilled Test System The species in which the cell line/test system originiated from is stated or able to be determind by description provided? Fulfilled Test System The test system (cell line/tissue/etc., whole-cell vs. cell-free) was described? Partially fulfilled Test System Were the methods either described in detail or in another publication to which a clear reference is made? Fulfilled Total 9 Funding and competing interests The funding sources for the study were stated? Fulfilled Funding and competing interests Any competing interests were disclosed or it was explicitly stated that the authors did not have any competing interests. Fulfilled Total 2 Administration of test compound Duration of treatment period was provided? Fulfilled Data Output Type 2_Outcome Level. Each evaluation question will have ONE response per experiment-chemical, making a variable total of questions per relevant experiment. Category Evaluation criteria Evaluation Result Administration of test compound It was stated that the effect of the test compound on cytotoxicity was measured? Fulfilled Administration of test compound The administered dose levels or concentration of treatment chemical was stated? Fulfilled Administration of test compound Were all test chemicals tested over a multiple concentrations? Fulfilled Administration of test compound The number of replicates per dose/concentration used or number of times the experiment was repeated was stated? Fulfilled Total 5 Data collection and analysis Acceptability and data interpretation criteria were provided? Fulfilled Data collection and analysis Do the author or reviewer report any concerns with the data reported? Fulfilled Data collection and analysis Measures of variability between replicates of a treatment group is reported (e.g. SD, SE, %CV, 95% CI, etc.)? Not applicable Data collection and analysis The time points for data collection were stated? Fulfilled Total 4 Background Literature Searching & Screening Development of a Curated, Cross-Species Androgen Receptor Database aU.S. EPA, ORD/CCTE/SCDCD, Duluth, Minnesota; bU.S. EPA, OCSPP/OPP, Washington, DC; cU.S. EPA, ORD/CCTE/GLTED, Duluth, Minnesota Sara M.F. Vliet a, Kristan J. Markey b, Scott G. Lynn b, Carlie A. LaLone c • The US Environmental Protection Agency (EPA) is tasked with assessing chemicals for their potential to adversely im


Raw LC Cleaned LC Iterative prewhitening PU Learning Smoothed LC P: Known Hybrids U: A/F Stars PU Classifier 1.0015 1.001 0 1.00 05 1.0000 0.9995 0.999 0 0.99 85 0.9980 Normalized Flux 1.0015 1.0010 1.0005 1.0000 0.9995 0.9990 0.9985 Final LC Smoothed LC Normalized Flux Positive Unlabelled Learning to Discover Hybrid Pulsating Stars in the TESS Catalogue Mykyta Kliapets (1), Pablo Huijse Heise (1), Andrew Tkachenko (1), Conny Aerts (1, 2, 3) (1) Institute of Astronomy, KU Leuven, Celestijnenlaan 200D, 3001, Leuven, Belgium (2) Department of Astrophysics, IMAPP, Radboud University Nijmegen, PO Box 9010, 6500 GL Nijmegen, The Netherlands (3) Max Planck Institute for Astronomy, Königstuhl 17, 69117 Heidelberg, Germany Correspondence email: nik.kliapets@gmail.com Problem Statement Data: TESS Light Curves (LCs) Methodology Results & Future Work δ Sct / γ Dor hybrid pulsating stars oscillating in both p- and g-modes are crucial for stella r astrophysics, yet not many of them are known. Large volumes of astronomical surveys (Kepler, TESS) make manual search impractical. Machine learning can help increase the available pool of hybrids with automated detection b y leveraging known ones. Known hybrids: 5,017 LCs of 522 known hybrid pulsators from 3 catalogues: Bowman et al (2016) , Li et al (2020), Skarka et al (2022). 1. Unlabelled stars: 122,137 LCs of A/F class stars from TESS Sectors 27 and 40 (Kunimoto et al 2021). 2. Labelled non-hybrids: 2,005 LCs of variable stars in 6 variability classes (Audenaert et al 2021). 3. Some hidden hybrids receive lower probabilities due to noisy data, requiring a cleaner training set (manual inspection of labelled LCs). Sources: Bowman, DM. et al. (2016). “Amplitude modulation in δ Sct stars: statistics from an ensemble study of Kepler targets”. In: Monthly Notices of the Royal Astronomical Society 460.2, pp. 1970–1989. Li, G. et al. (2020). “Gravity-mode period spacings and near-core rotation rates of 611 γ Doradus stars with Kepler”. In: Monthly Notices of the Royal Astronomical Society 491.3, pp. 3586–3605. Skarka, M. et al. (2022). “Periodic variable AF spectral type stars in the northern TESS continuous viewing zone-I. Identification and classification”. In: Astronomy & Astrophysics 666, A142. Kunimoto, M. et al. (2021). “Quick-look pipeline lightcurves for 9.1 million stars observed over the first year of the TESS Extended Mission”. In: Research Notes of the AAS 5.10, p. 234. Audenaert, J. et al. (2021). “TESS data for asteroseismology (T’DA) stellar variability classification pipeline: setup and application to the Kepler Q9 data”. In: The Astronomical Journal 162.5, p. 209. Bekker, J. and Davis, J. (2020). “Learning from positive and unlabeled data: a survey”. In: Machine Learning 109.4, pp. 719–760. New hybrid candidates: 112 LCs from TESS Sectors 27 and 40 with probabilities in [0.98, 1]. Acknowledgement: This Master’s Thesis research was funded with the 2023 Kavli Scholarship in machine learning for astrophysics, given by the Kavli Foundation. Each TESS LC is a separate training example. Using TESS quality flags and removing outliers. Subtracting the moving average to remove instrumental trend. Extracting up to 5 periods in both p- and g-mode regimes with an SNR check. Bagging ensemble outputs a probability of each unlabelled LC being a hybrid pulsator. We are only using extended mission data. Hundreds of millions of stars observed by space telescopes TESS Sectors 27 & 40. Remaining TESS Sectors (and Kepler data) contain hybrid pulsators and other variable phenomena waiting to be detected with PU Learning. 350 300 250 200 150 100 50 0 0 10 60 70 Periodogram p-mode g-mode 20 30 40 50 Frequency [1/d] Power [ppm] 1200 1000 800 600 400 200 0 0 10 20 30 40 Frequency [1/d] 50 Periodogram p-mode g-mode 60 70 Power [ppm] 1.0 0.8 2770 2775 2780 2790 2795 2785 Normalized Flux 0.9 0.7 0.6 Time [d] 2770 2775 2780 2790 2795 2785 Time [d] 2770 2775 2780 2790 2795 2785 Time [d] 10^4 10^3 10^2 10^1 10^0 0


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The N-terminal MADA motif in the CC-NLR immune receptors is functionally conserved across distantly related plant species ●Hiroaki Adachi1, Mauricio Contreras1, Adeline Harant1, Chih-hang Wu1, Lida Derevnina1, Toshiyuki Sakai1, Cian Duggan2, Eleonora Moratto2, Tolga O Bozkurt2, Abbas Maqbool1, Joe Win1, Sophien Kamoun1 1The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich NR4 7UH, UK. 2Imperial College London, Department of Life Sciences, London, UK. 1. Plant CC-NLRs form resistosome “death switch” 9. ACKNOWLEDGMENTS Model of NLR network for effector recognition. NRC, NLR required for cell death. modified from Wu et al. (2017) PNAS Wang et al. (2019) Science 2. NLRs form a receptor network composed of functionally specialized “sensor” and “helper” NLRs In vitro transposon insertion Truncation library in Agrobacterium Functional validation in N. benthamiana Premature STOP codons NRC4DV MuA D478V V 0 100 200 300 400 500 600 700 800 900 HR - HR + 1 145 504 881 9 CC NB-ARC LRR Amino acid position 3. Transposon-based truncation mutagenesis reveals 29 amino-acid region sufficient for NRC4-mediated cell death NRC41-29-YFP NRC4DV-YFP NRC4WT-YFP YFP TRIBE-MCL LRR NB-ARC CC 0 50 100 150 200 250 Number of proteins 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 59 RPM1, MLA10, Sr33, Sr50, Pik-1, Pik-2, RGA4, RGA5 Hero, Mi1.2, Rpi-blb2, Sw-5b R1 RPS5 Bs2 Prf Gpa2, Rx ADR1 NRG1 N-terminal domain tribes NRC2, NRC3, NRC4, ZAR1, RPP8, RPP13, R2, Rpi-vnt1 R3a Dicot Monocot 4. The MADA motif is conserved at the N-terminus of NRC4 and ZAR1 Dataset: 988 CC/CCR-NLRs from Arabidopsis, sugar beet, tomato, N. benthamiana, rice and barley. NRC4 MADA motif 1 21 0 1 2 3 4 bits 1 E R A L VM 2 G Y T L VA 3 A N S T G ED 4 I G T V E SA 5 G T I A F L V 6 M T LIV 7 D K G A E T NS 8 N T Y P S K L VF 9 S F V G L A 10 A T LIV 11 D G N S KQE 12 L Q A R S I W NK 13 V Y T A IL 14 Q S A M K L W G 15 H T K G E S N Q D 16 Q T W Y I V FL 17 E M V I AL 18 A E R T L V S I 19 K N S Y H R D E Q 20 H K Q NE 21 W G Y C I S A V 1 MADAVVNFLVENLLQLLTDNV 21 1 MVDAVVTVFLEKTLNILEEKG 21 NRC4 ZAR1 LRR NB-ARC CC NRC41-29 NRC4DV A B A, Clustering N-terminal domain of CC-NLRs by Tribe-MCL analysis. B, The consensus sequence pattern of the MADA motif identified by MEME. NRC-S without NTD NRC-H family NRC-S with NTD 0.1 NRC superclade Mi-1.2 Rpi-blb2 Hero Sw5b R1 Prf Bs2 Gpa2 Rx NRC4 NRC2 NRC3 Tree scale: 0.2 ZAR1 RPP13 R2 RPP8 RPi-vnt1 Pik-2 Tree scale: 0.2 Other NLRs MADA-CC-NLRs Bootstrap value > 0.7 6. NRC sensors do not have the MADA motif NRC-H: NRC helpers, NRC-S: NRC dependent sensors, NTD: N-terminal extension domain 0 5 10 15 20 25 30 35 40 Rice Barley Arabidposis Sugar beet Tomato N. benthamiana 0 5 10 15 20 25 30 35 40 Rice Barley Arabidposis Sugar beet Tomato N. benthamiana Frequency (%) MADA-CC-NLR MADAL-CC-NLR 15/371 4/229 25/72 14/88 32/133 14/81 72/371 36/229 1/72 4/88 5/133 13/81 5. The MADA motif is present in ~20% of CC-NLRs MADA HMM LRR NB-ARC CC Dataset: 988 CC/CCR-NLRs from Arabidopsis, sugar beet, tomato, N. benthamiana, rice and barley. Occurrence of MADA-CC-NLRs in monocots and dicots. MADAL-CC-NLR: MADA-like CC-NLR Pathogen Effector(s) Singleton NLR NLR network NLR pair Sensor NLR Helper NLR Time Specialization Diversification ▶ Degenerated MADA motif ▶ N-terminal domain integration ▶ Conserved MADA motif ▶ Conserved MADA position Sensor NLR Helper NLR Convergent downstream Hypersensitive cell death and disease resistance AvrBs2 CP AvrPto/ AvrPtoB AVR1 NSm Avr8 Avrblb2 Unknown protein Unknown protein RBP-1 NRC2 NRC3 NRC4 Gpa2 Rx Bs2 Prf R1 Sw5b R8 Rpi-blb2 Mi A B C A, Overview of the strategy for transposon-based C-terminal random truncation of NRC4 proteins. B, NRC41-29::Mu-STOP triggers cell death in N. benthamiana leaves. C, NRC41-29-YFP induces cell death in N. benthamiana leaves. The phylogenetic trees of the 988 CC-NLRs (Left) and the NRC superclade (right). NRC4WT NRC4DV NRC21-17


Stakeholder bei Open Access Publikationen in den Geistes- wissenschaften Open-Access- Projekte Repositorien Scholar-led Verlage Open-Access- Dienstleister Autor:innen Großverlage Universitäts- verlage Kleine/mittlere Fachverlage Infrastruktur- Plattformen Fachgesell- schaften Forschende Lehrende Gesellschaft und Wirtschaft Medien Stiftungen NGOs Öffentliche Forschungs- förderung Politik Leser:innen Verlage Weitere Akteur:innen Was passiert im Forschungsprojekt AuROA? Wir entwickeln Musterverträge und arbeiten für mehr Kooperation und Standardisierung bei Open- Access-Buchpublikationen. Stakeholder-Workshops stellen sicher, dass die Perspektiven aller am Publikationsablauf beteiligten Akteur:innen in die Musterverträge eingehen. Ein aufgabenzentrierter Leistungskatalog über die Bedarfe und Optionen bei einer Open-Access- Publikation soll den Ablauf einer Veröffentlichung transparenter und einfacher gestalten. Kernziel des Verbundprojekts AuROA ist die Entwicklung von rechtssicheren, vielfältig einsetzbaren Musterverträgen. Diese decken Themen ab wie wissenschaftliche sowie technische Qualitätssicherung, vereinbarte Dienstleistungen, Nutzungsrechte und freie Lizenzen. Die Verträge sollen den hohen Standards wissenschaftlicher Publikationen einen rechtssicheren Rahmen geben und Unsicherheiten sowie Vorbehalte gegenüber Open Access bei allen Beteiligten abbauen. Universitäts- bibliotheken Weitere Rollen von Autor:innen (Teil-)Funktionen von Universitätsbibliotheken „Wo sehen Sie Handlungsbedarf?“ Befragung Stakeholder-Workshop 01.07.2021 (n=14, Mehrfachnennung möglich) Privatwirtschaftlich Öffentlich finanziert Unterschiedlich finanziert Wissenschaft www.projekt-auroa.de Projektlaufzeit: Februar 2021 – Januar 2023 Yuliya Fadeeva, Universität Duisburg-Essen yuliya.fadeeva@uni-due.de Matthias Laugwitz, IST-Hochschule für Management mlaugwitz@ist-hochschule.de Veröffentlicht unter CC BY 4.0


INTRODUCTION NUMERICAL EXPERIMENTS RESULTS DISCUSSION AND CONCLUSION A Geodynamic Modeling Investigation of Plume-Lithosphere Interactions Beneath the East African Rift Tahiry Rajaonarison, Sarah Stamps, John Naliboﬀ, Andrew Nyblade Virginia Tech (dstamps@vt.edu), New Mexico Tech, Penn State University 1 1 3 1 2 REFERENCES Alejano, L. R., and A. Bobet. Drucker–prager criterion (2012), in The ISRM Suggested Methods for Rock Characterization, Testing and Monitoring: 2007-2014, pp. 247–252, Springer . Amante, C., & Eakins, B. W. ETOPO1 arc-minute global relief model: procedures, data sources and analysis (2009). Arndt D. , W. Bangerth, T. C. Clevenger, D. Davydov, M. Fehling, D. Garcia-Sanchez, G. Harper, T. Heister, L. Heltai, M. Kronbichler, R. M. Kynch, M. Maier, J.-P. Pelteret, B. Turcksin, D. Wells (2019), The deal.II Library, Version 9.1, Journal of Numerical Mathematics, Volume 27, Issue 4, Pages 203-213. Bagley, B., and A. A. Nyblade (2013), Seismic anisotropy in eastern africa, mantle ﬂow, and the african superplume, Geophysical Research Letters , 40 (8), 1500–1505, doi:10.1002/grl.50315. Bangerth, W., T. Heister, et al. (2015), ASPECT: Advanced solver for problems in Earth’s convection, Computational Infrastructure for Geodynamics. Bangerth, W., J. Dannberg, R. Gassmoeller, T. Heister, et al. ASPECT v2.2.0 [software] (2019). Bassin, Chantal (200), "The current limits of resolution for surface wave tomography in North America." EOS Trans. AGU. 81: Fall Meet. Suppl., Abstract. Chapman, D. (1986) Thermal gradients in the continental crust, Geological Society, London, Special Publications , 24 (1), 63–70. cal Research: Solid Earth, 86(B4), 2825-2852. Kronbichler, M., T. Heister, and W. Bangerth (2012), High accuracy mantle convection simulation through modern numerical methods, Geophysical Journal International, 191(1), 12–29, doi: 10.1111/j.1365-246X.2012.05609.x. 2 3 GOVERNING EQUATIONS MODEL ASSUMPTIONS AND CHARACTERISTIC WORK IN PROGRESS TESTING THE ROLE OF MULTIPLE PLUMES OR SUPERPLUME Coblentz, D. D., and M. Sandiford (1994), Tectonic stresses in the african plate: Constraints on the ambient lithospheric stress state, Geology , 22 (9), 831–834Dziewonski, A. M., Chou, T. A., & Woodhouse, J. H. (1981), Determination of earthquake source parameters from waveform data for studies of global and regional seismicity. Journal of Geophysical Research: Solid Earth, 86(B4), 2825-2852. Edwards, M. O. 1989, "Global gridded elevation and bathymetry (ETOPO5)." Digital raster data on a 5. Ekström, G., M. Nettles, and A. Dziewonski (2012), The global cmt project 2004–2010: Centroid-moment tensors for 13,017 earthquakes, Physics of the Earth and Planetary Interiors , 200, 1–9. Emry, E. L., Shen, Y., Nyblade, A. A., Flinders, A., & Bao, X. (2019), Upper mantle earth structure in Africa from full‐wave ambient noise tomography. Geochemistry, Geophysics, Geosystems, 20(1), 120-147, doi:10.1029/2018GC007Glerum, A., Brune, S., Stamps, D. S., & Strecker, M. R. (2020), Victoria continental microplate dynamics controlled by the lithospheric strength distribution of the East African Rift. Nature Communications, 11(1), 1-15. Kronbichler, M., T. Heister, and W. Bangerth (2012), High accuracy mantle convection simulation through modern numerical methods, Geophysical Journal International, 191(1), 12–29, doi: 10.1111/j.1365-246X.2012.05609.x. Pasyanos, M. E. (2013), A lithospheric attenuation model of North America. Bulletin of the Seismological Society of America, 103(6), 3321-3333, doi:10.1785/0120130122. Saria, E., E. Calais, D. Stamps, D. Delvaux, and C. Hartnady. Present-day kinematics of the east african rift, Journal of Geophysical Research: Solid Earth, 119(4), 3584–3600 (2014). Stamps, D. S., Saria, E., & Kreemer, C. A geodetic strain rate model for the East African Rift System. Scientiﬁc Reports, 8(1), 1-8 (2018). Stamps, D., L. Flesch, E. Calais, and A. Ghosh. Current kinematics and dynamics of africa and the east african rift system, Jou


BURDEN OF TUBERCULOSIS IN MALAYSIA: AN OVERVIEW FOR 2015 Nur Hamizah Nasaruddin1, Shubash Shander Ganapathy1, Mohd Azahadi Omar2, Mohamad Fuad Mohamad Anuar1, LeeAnn Tan1, Nazirah Alias1 1INSTITUTE FOR PUBLIC HEALTH, NATIONAL INSTITUTES OF HEALTH, SHAH ALAM, MALAYSIA 2SECTOR FOR BIOSTATISTICS AND DATA REPOSITORY, NATIONAL INSTITUTES OF HEALTH, SHAH ALAM, MALAYSIA P-10 NMRR-18-609-41165 INTRODUCTION RESULTS Tuberculosis caused in Malaysia for the year 2015. MATERIALS AND METHODS The calculation of burden of disease in terms of DALY was done using the methodology used in the Global Burden of Disease Study2. The DALYs for tuberculosis were calculated by summing the Years of Life Lost (YLL) with the Years Lived with Disability (YLD). The YLLs were calculated using the mortality and life expectancy data obtained from Malaysia’s Department of Statistics. The YLDs were produced using prevalence derived from DISMOD-II software based on incidence data provided by Malaysia’s disease notification system. YLL YLD One DALY can be thought of as ONE LOST YEAR OF HEALTHY LIFE for the entire population2. DALY DALY is a health gap2. Tuberculosis is a preventable disease but still remains a public health concern. This study aims to describe Malaysia’s burden of tuberculosis for the year 2015 in terms of Disability Adjusted Life Years (DALYs). The World Health Organization (WHO) estimated that nearly ONE QUARTER OF THE WORLD population are at risk of progression to tuberculosis disease1. YLL (71.2%) YLD (28.8) (mortality component) (morbidity component) The MORTALITY COMPONENT was higher than the morbidity component. The RATE of tuberculosis burden increases with age and was highest among those AGED 65 YEARS AND OLDER. 0-14 15–24 25-54 55-64 65+ 419 336 208 68 10 AGE GROUP (YEARS) DALY PER 100,000 POPULATION The reduction of tuberculosis morbidity and mortality among MALES can potentially reduce a large number of tuberculosis burden in Malaysia. Stronger approaches towards lowering the number of non-communicable diseases could help lessen Malaysian ELDERLY’s risk of tuberculosis progression and deaths. CONCLUSION The authors would like to thank the Director General of Health Malaysia for his permission to publish this article. REFERENCES 1. World Health Organization. Global tuberculosis report 2019. 2. Colin M et al. National burden of disease studies: A practical guide. Global program on evidence for health policy. Geneva: World Health Organization. 2001. 3. Suchunya A et al. Decreasing the burden of infectious disease in Thailand. The Lancet 2013; 381 S11. 4. Pamela Nogueira Silva V et al. Burden of tuberculosis trends in a Brazilian southern state. Rev bras epidemiol 2018. 5. Horton KC et al. Sex differences in tuberculosis burden and notifications in low- and middle-income countries: A systematic review and meta- analysis. PLoS Med 2016; 13 1-23. Population aged between 25- 54 YEARS OLD caused the highest tuberculosis burden. AGE GROUP (YEARS) % OF DALY 1.7% 57.4% 16.2% 16.0% 8.7% 65 + 55 - 64 25 - 54 15 – 24 0 - 14 MALES contributed more DALYs compared to females. 63.3% 30.7% 4 7 , 7 3 6 D A L Y s Malaysia’s burden of tuberculosis accounted for 0.9% of the overall DALYs in 2015, which is much lower compared to those observed in other countries such as Thailand (1.4% of overall DALYs in 2009) and Brazil (2% of overall DALYs in 2010)3,4. Timely detection and prompt treatment should be emphasized to prevent early deaths and subsequently reduce the high tuberculosis mortality burden. Reducing the tuberculosis burden among males could be done most efficiently by improving access for tuberculosis care for males, providing counseling sessions as well as lost of wages compensation5. Mass media campaigns on tuberculosis awareness programs, targeting age-specific groups could help reach those within the high tuberculosis burden categories. DISCUSSION