Ra Influence of Liquid/Gas ratio and alkalinity on photosynthetic biogas upgrading efficiency in an outdoors tubular photobioreactor David Marín1, Antonio Ortíz2, Enrica Uggetti2, Joan García2, Raquel Lebrero1, Raúl Muñoz1,* 1 Department of Chemical Engineering and Environmental Technology, Valladolid University. * mutora@iq.uva.es 2 GEMMA-Environmental Engineering and Environmental Group, Universitat Politècnica de Cataluña INTRODUCTION • Biogas from the anaerobic digestion of solid wastes constitutes an important energy source able to decrease the dependence on fossil energy in our current society. • The use of biogas as a substitute of natural gas or fuel in transportation requires an effective purification to levels set by international regulations. Biogas injection into natural gas grids typically requires concentrations of CH4 ≥95%, CO2 ≤2%, O2 ≤0.3% and negligible amounts of H2S. • Algal-bacterial processes have emerged as a cost effective and environmentally friendly alternative for biogas upgrading compared to conventional physical/chemical or biological technologies. • Bahr, M., Díaz, I., Dominguez, A., González Sánchez, A., Muñoz, R., 2014. Microalgal-biotechnology as a platform for an integral biogas upgrading and nutrient removal from anaerobic effluents. Environ. Sci. Technol. 48, 573–581. doi:10.1021/es403596m • Marín, D., Posadas, E., Cano, P., Pérez, V., Blanco, S., Lebrero, R., 2018. Seasonal variation of biogas upgrading coupled with digestate treatment in an outdoors pilot scale algal-bacterial photobioreactor. Bioresour. Technol. 263, 58–66. https://doi.org/10.1016/j.biortech.2018.04.117 • Muñoz R., Meier L., Díaz I. and Jeison D. (2015) A review on the state-of-the-art of physical/chemical and biological technologies for biogas upgrading. Rev. Environ. Sci. Biotechnol. 14:727–759 Aknowledgments: This work was supported by the project INCOVER. The project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the grant agreement No. 689242. MATERIALS AND METHODS RESULTS AND DISCUSSION CONCLUSIONS Microalgae BioFertilizer H2S CO2 BioCH4 SO4 2- O2 Solar Energy Digestate Organic Waste Anaerobic Digester Biogas CH4 CO2 H2S Aims of this study: • Study the influence of the liquid/gas ratio on the quality of the upgraded biogas. • Evaluate the influence of alkalinity on the absorption column. Two experimental series were conducted: • During the first experimental series, biogas was sparged into the absorption column (AC) under co-current flow operation in order to evaluate the influence of the liquid/gas ratio (L/G). • During the second experimental series, the influence of the alkalinity on the AC was studied. Biogas was sparged into the AC under co-current flow operation with an addition of a carbonate solution (NaHCO3 and Na2CO3) with a concentration of 16000 mg L-1 of inorganic carbon (IC) Experimental Set-up used for this study Evaluation of the liquid/gas ratio in the absorption column L/G Ratio Liquid Volume (L d-1) Biogas Volume (L d-1) 0.5 50 100 1.0 100 100 2.0 200 100 3.0 300 100 4.0 400 100 5.0 500 100 Evaluation of the influence of alkalinity on the absorption column L/G Ratio IC Concentration (mg L-1) Carbonate Solution (L d-1) 0.5 16000 0 1 2 3 5 The increase in the L/G ratio mediated a higher desorption of O2 and N2, which negatively impacted the final concentration of CH4 in the upgraded biogas. REFERENCES • To the best of our knowledge, this research constitutes the first evaluation of the use of microalgae for biogas upgrading under outdoors conditions at a pilot scale. • This research confirmed the key role of the liquid/gas ratio on the biogas upgrading efficiency. • The results herein obtained confirmed the key role of alkalinity on the biomethane quality. Evaluation of the liquid/gas ratio in the absorption column Evaluation of the influence of alkalinity on the absorption column Liquid Recirculation Pump Biogas Pump External Liquid Recirculat


COOL STARS 21, Toulouse, France New insights into the rotational evolution of near-solar age stars from M 67 David Gruner1,2, Sydney A. Barnes1,3, and Jörg Weingrill1 1 Leibniz-Institute for Astrophysics Potsdam, Germany 2 University of Potsdam, Germany 3 Space Science Institute, Boulder, CO, USA dgruner@aip.de CONTEXT AND MOTIVATION Gyrochronology allows the derivation of ages for cool main sequence stars based on their observed rotation periods and masses, or a suitable proxy for the latter. It is increasingly well-explored for young FGK stars in open clusters, but few calibrators are available for stars with ages over 1 Gyr, and virtually none for late-K or M-type stars. Our work is aimed at such extensions. LIGHTCURVES FROM THE K2 M 67 SUPERSTAMP Stellar open clusters provide the best environment for related work, because they offer well-defined samples of coeval stars of the same composition. Ac- cordingly, we investigated the hitherto unstudied superstamp created during the Kepler/K2 mission for the 4 Gyr-old benchmark open Cluster M 67. We con- structed a list of cluster stars based on Gaia DR2 and obtained aperture pho- tometry lightcurves for them (cf. panel (a) of Fig. 1). The infamous K2 lightcurve systematics are tamed using a flux correction that models the position depen- dency of the flux (transition to panel (b), same figure), and a Principal Com- ponent Analysis (transition to panel (c), same figure). In the set of lightcurves produced, we identify 39 main-sequence cluster members that exhibit periodic variations ascribed to stellar rotation. 0.96 0.98 1.0 1.02 1.04 Aperture photometry (a) 0.96 0.98 1.0 1.02 1.04 Normalized flux Flux corrected (b) Gaia DR2 604969267746267520 (G −RP)0 = 0.86 mag, G = 17.3 mag PCA 140 150 160 170 180 190 200 210 Time [BJD−2457100 d] 0.96 0.98 1.0 1.02 1.04 PCA corrected (c) One rotation, Prot = 26.0 Double dipping star Figure 1: Lightcurves of a sample star. Panel (a) shows the raw lightcurve from aperture photometry, panel (b) shows the lightcurve after a correction for the telescope jitter, and panel (c) shows the lightcurve after the application of a PCA-based trend correction. ROTATIONAL CLUSTER SEQUENCE OF M 67 We identified rotation periods in stars ranging from the turn-off point (G0) to mid-M stars (blue points in Fig. 2 ). Our data overlap in color range with the sample of Barnes et al. (2016) in the CMD and CPD, and extend it to much later type stars. We find that rotation periods for stars later than mid-K do not show the period increasing uniformly with color that is seen in younger clusters. They instead reach a minimum in period at late-K type before rising again towards the red. Figure 2: Color-Period diagram for M 67. Rotation periods from this work are in blue, while the ones from Barnes et al. (2016) are in orange. The highlighted star is the one shown in Fig. 1. THE BIGGER PICTURE Our M 67 results now confirm what was already suggested by an investigation of the 2.5 Gyr-old open cluster Ruprecht 147 (e.g., Gruner & Barnes 2020, Curtis et al. 2020). 2.5 – 4 Gyr-old stars later than early-K rotate faster than anticipated. This contradicts certain prior pre- dictions and suggests the involvement of a third distinct physical process for an accurate description of rotational evolution. However, our data confirm that cool stars continue to populate a single surface in rotation period-age-mass space until at least 4 Gyr. Furthermore, all three avail- able time steps for older stars (i.e., 1, 2.5, and 4 Gyr, Fig. 3 ) are clearly distinct in rotation period, an essential requirement for gyrochronology. 0.4 0.5 0.6 0.7 0.8 0.9 1.0 1.1 Color (G −RP)0 [mag] 15 15 20 20 25 25 30 30 35 35 Rotation period P [d] This work Barnes et al. 2016 G0 K0 K2 K5 K7 M0 M1 M3 Spectral type References Barnes, S. A., Weingrill, J., Fritzewski, D., et al. 2016, ApJ, 823, 16 Curtis, J. L., Agüeros, M. A., Douglas, S. T., & Meibom, S. 2019, ApJ, 879, 4 Curtis, J. L., Agüeros, M. A., Matt, S.


GEANT4 rendering of the EDELWEISS cryostat and the detectors. Experimen Due to their small size they have small hea The muon signals are very large and are affected by non-linearities of the TES We fit the muon pulse using a thermal model and extract thermal parameters that affect energy resolution. Development of transition-edge sensor based large area photon detectors for CUPID Vivek Singh, UC Berkeley Neutrino - 2020 (Poster # 97) CUPID: CUORE Upgrade with Particle ID Transition-edge sensors for photon detectors Next generation bolometric search for 0𝜈𝛽𝛽 experiment. CUPID pre-CDR (arXiv:1907.09376) Detector performance V Singh 1, W Armstrong 2, G Benato 1, 3, M Beretta 1, C L Chang 4,5 , B K Fujikawa 3, K Hafidi 2, E Hansen 1, R Huang 1, G Karapetrov 6, Yu Kolomensky 1, 3, M Lisovenko 7,8, L Marini 1, Z Meziani 2, J Pearson 7, T Polakovic 2,6, B Schmidt 3, V Novosad 2,7, K J Vetter 1, S Wagaarachchi 1, G Wang 4, B Welliver 3, V Yefremenko 4, J Zhang 4 1 Department of Physics, University of California, Berkeley, Berkeley, CA. 2 Physics Division, Argonne National Laboratory, Chicago, IL. 3 Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA. 4 High Energy Physics Division, Argonne National Laboratory, Chicago, IL. 5 Kavli Institute for Cosmological Physics, University of Chicago, Chicago, IL. 6 Department of Physics, Drexel University, Philadelphia, PA. 7 Materials Science Division, Argonne National Laboratory, Chicago, IL. 8Nanoelectronics Department, Sumy State University, Sumy, Ukraine • Increase sensitive mass by enrichment • Active background rejection through 𝛼 / (𝛽-𝛾) separation • Goal: ➡△EFWHM ≤ 5 keV @ 2615 keV ➡B = 0.1 c/ton/y in ROI ➡<m𝛽𝛽> ~ 10 meV discovery sensitivity (10 yrs of live time) •CUORE has successfully demonstrated that a ton scale bolometric experiment is feasible. •CUPID will build on the experience of CUORE and use its cryogenic infrastructure. •Li2MoO4 detectors recognized as baseline •Enrichment > 95% •~ 1500 crystals with ~ 250 kg of 100Mo •Demonstrated active background rejection. [see Poster ID 419. on the CUPID-Mo experiment by Benjamin Schmidt] Rendering of CUORE cryostat with 1500 crystals inside it •Dominant background is degraded alphas from surface contamination •Leverage energy loss mechanism in the crystal to tag particle type •Use auxiliary low temperature calorimeter to detect light. Should have High radiopurity Low heat capacity High photon collection efficiency Very low threshold (~ 100 eV) Excellent timing resolution to discriminate the 2𝜈𝛽𝛽 pile up events from 0𝜈𝛽𝛽 events. Particle ID •Low transition temperature with relatively fast fabrication time possible with “bilayers” •Negative electrothermal feedback keeps TES stable and decreases sensor time constant ; faster pulses •Iridium goes superconducting at ~ 140 mK. We use the proximity effect of a normal metal (like, Au and Pt) to reduce the Tc. Device specification: •2” Silicon wafer as optical photon absorber •Ir/Pt (100 nm/60nm) bilayer with Nb traces as electrical leads. •Transition temperature of ~ 37 mK •Sensor dimension 300 𝜇m x 300 𝜇m • We have deposited Au pads, coupling the TES to the wafer for better phonon collection efficiency • Tc relatively unchanged with addition of Au pads but signal-to-noise improves drastically. square Ir/Pt bilayer TES square Ir/Pt bilayer TES in the middle with Au pads on both sides IV characteristics • We can operate the detector down to 10 mK by choosing a suitable bias point. • Due to the steep slope in the biased region, the sensitivity of a TES is much larger than NTD- Ge thermistors (CUORE like sensors) Timing resolution • Generate a train of blue LED light pulse with known separation time >> decay time • Examine distribution of trigger time between the subsequent pulses in detector response • Timing resolution of 𝛥t ~ 5 𝜇s • Detector satisfies the criteria for rejecting 2𝜈𝛽𝛽 pile up events (top) Detector response to train of LED pulses of varying amplitude inj


Reactivity of oxidising radicals with functionalised surfaces Wolstenholme-Hogg, Amy;a Iqbal, Naeem;a and Chechik, Victora aDepartment of Chemistry, University of York, Heslington, York YO10 5DD U.K. 1 Background 3 Computational modelling 6 Conclusions 1. Ulman A. Formation and Structure of Self-Assembled Monolayers. Chemical Reviews. 1996;96(4):1533-54. 2. De Keer L, Van Steenberge P, Reyniers M-F, Gryn'ova G, Aitken HM, Coote ML. New mechanism for autoxidation of polyolefins: kinetic Monte Carlo modelling of the role of short-chain branches, molecular oxygen and unsaturated moieties. Polymer Chemistry. 2022;13(22):3304-14. 3. Smith LM, Aitken HM, Coote ML. The fate of the peroxyl radical in autoxidation: how does polymer degradation really occur? Accounts of chemical research. 2018;51(9):2006-13. • The studies using mixed monolayers with radical initiators have shown degradation of the neighbouring chains, suggesting autoxidation does occur in monolayer systems. • These findings counteract the kinetic model, which showed no alkane degradation should occur due to the rate of peroxyl radical termination being much higher than H-abstraction by a peroxyl radical. • However, the results support the statistical model which suggest the majority of peroxyl radicals would be too far away from each other to react. Therefore, they can only react with neighbouring organic chains or atmospheric molecules. Non-porous silica nanoparticles have been used as model substrates. Approx. 2.5 molecules/nm2 TGA 0 20 40 60 80 100 120 140 f1 (ppm) 0 50000 100000 150000 200000 250000 i6042c.1.fid AVIIIHD400WB Carbon-13 100MHZ 2.5mm i6042c Amy Wolstenholme-Hogg AWH-C8 20 Solid state 13C NMR Si O O O Silica NPs 10-20nm Radical generation within monolayers Oxidative cleavage of the molecules from the silica surface enables the analysis and quantification of the molecular structures after reactivity by 1H NMR and GC-MS. GC-MS 1H NMR Using 1H NMR and GC-MS, the degradation of neighbouring chains can be monitored to give an understanding of the extent to which radical reactions propagate throughout the monolayer systems after exposure to UV light. The critical step is whether the newly formed peroxyl radicals continue to abstract a H from a neighbouring chain and the propagation of radical reactions occurs or whether they undergo termination to form stable products. Radical propagation Peroxyl termination • Reaction of the sensor surface with an •OH can result in the oxidation of several molecules in the monolayer through autoxidation. • This could increase the sensor sensitivity but also reduce its lifetime. • The aim is to assess the degree of autoxidation – the spreading of radical reactions laterally in the monolayer. 1 2 a a b c c c c b a b c 1) Initiation 2) Reaction with O2 3) Peroxyl radical formation 4) Peroxyl radical termination 4) Radical propagation OR Silica surface 2 Project Aims Functionalisation of silica surfaces •OH 1.8 x10-9 L mol-1 s [2] Statistical model Kinetic model 4 Methodology Dissociation of molecules from silica surfaces Si O Si O Si MeO OMe O O NP surface UV radical initiator (Surface bound) Si O Si O Si MeO OMe N N N N N N N N Thermal radical initiator (Surface bound) Si O Si O Si MeO OMe N N N N N N N N N N N N Thermal radical initiator (Not surface bound) NP surface NP surface UV radical initiation Silica nanoparticles have been functionalised with mixed monolayers of an organic molecule with a radical initiator. Silica surface • Assume 10% of the molecules in a monolayer form active radicals at a given time. • Random generation of 10% points in a grid. Minimum distances plotted as distribution. • 5 molecules/nm2. • Distance between molecules 0.6 nm. • Length of monolayer chains ~0.6 nm • 46% ROO• are close enough to react. • 54% ROO• are more likely to propagate than terminate in monolayer systems. O O O O O O O O F F F F 5 F F F F F 5 F NP surface NP surface NP surface ether alkane perfluoro • Functionalised nanoparticles


Habitability conditions and radio emission under calm and extreme space weather conditions around Proxima b Luis Pe˜na-Mo˜nino1, Miguel P´erez-Torres1, Jacobo Varela2 & Philippe Zarka3 1CSIC, Instituto de Astrof´ısica de Andaluc´ıa, Granada, Spain 2 Institute for Fusion Studies, University of Texas, Austin, TX 78712, United States, 3 LESIA, Observatoire de Paris, CNRS, PSL, SU/UPD, Meudon, France We acknowledge support through the Severo Ochoa grant CEX2021-001131-S and the Spanish National grant PID2020-117404GB-C21, funded by MCIU/AEI/ 10.13039/501100011033. LPM also acknowledges funding through grant PRE2020-095421, funded by MCIU/AEI/10.13039/501100011033 and by FSE Investing in your future. We also acknowledge the Spanish Prototype of an SRC (SPSRC) service and support financed by the Spanish Ministry of Science, Innovation and Universities, by the Regional Government of Andalusia, by the European Regional Development Funds and by the European Union NextGenerationEU/PRTR. MOTIVATION and GOALS MOTIVATION: • Habitability of exoplanets hosted by M dwarfs drastically depends on space weather. • Main players: ram and magnetic pressure of stellar wind + magnetic field of exoplanet. • Most likely drive radio emission arising close to the planet. GOALS: ▶Characterize habitability of the Earth-like planet Proxima b using 3D MHD simulations. ▷Calm and extreme space weather conditions. ▷Study role of stellar wind and planetary magnetic field, and their mutual orientation. ▶Determine radio emission arising from interaction between the stellar wind of Proxima and the magnetosphere of its planet Proxima b. MHD simulations - We used PLUTO: open 3D magneto-hydrodynamic code Main parameters of the PLUTO simulations Parameter Calm space weather Extreme space weather Sub-Alfv´enic Super-Alfv´enic CME scenario scenario scenario nsw [cm−3] 50 50 250 |vsw| [× 107 cm s−1] 5 10 25 BIMF [mG] 3.2 1.6 16 BProxima [G] 1200 600 600 BProxima b [G] 0.16−1.28 0.16−1.28 0.16−0.64 i [degrees] [0 - 90] [0 - 90] [0 - 45] ▶Sub-Alfv´enic scenario: ρsw v 2 sw < B2 sw/(8 π) ▶Super-Alfv´enic scenario: ρsw v 2 sw > B2 sw/(8 π) (Bow shock is formed) ▶Coronal mass ejection: Super-Alfv´enic scenario, with both ρsw v 2 sw and B2 sw/(8 π) increased enormously for short time period. HABITABILITY - Magnetopause standoff distance as a proxy for planetary shielding - Life not that harsh in Proxima b! 0 20 40 60 80 Tilt(deg) 1 2 3 4 5 Rmp/RProxima b Sub-Alfvénic Standoff distance 0 20 40 60 80 Tilt(deg) 1 2 3 4 5 6 7 Rmp/RProxima b Super-Alfvénic Standoff distance 0 10 20 30 40 Tilt(deg) 1.5 2.0 2.5 3.0 3.5 Rmp/RProxima b CME Standoff distance 0.64G 0.32G 0.16G 0.2 0.4 0.6 0.8 1.0 1.2 BProxima b(G) 4 5 6 7 8 9 Rmp/RProxima b Sub-Alfvénic Standoff distance 23 deg 0 deg 0.2 0.4 0.6 0.8 1.0 1.2 BProxima b(G) 6 7 8 9 10 11 12 Rmp/RProxima b Super-Alfvénic Standoff distance 23 deg 0 deg 0.2 0.3 0.4 0.5 0.6 BProxima b(G) 1.5 2.0 2.5 3.0 3.5 Rmp/RProxima b CME Standoff distance 45 deg 23 deg 0 deg • Shielding decreases as tilt increases (top). • Shielding increases as intrinsic planetary magnetic field increases (bottom panels). ▶Calm space weather: If magnetic field of Proxima b similar to that of the Earth (Bp = B⊕≈0.32 G) or larger, magnetopause standoff distance is large enough to shield the surface from the stellar wind for essentially any planetary tilt. ▶Coronal mass ejection (CME): Proxima b well shielded if magnetosphere Earth-like (Bp≈B⊕), or tilt smaller than that of Earth (i ≈i⊕≈23.5 deg). RADIO EMISSION - Detection prospects - Radio emission very high under Super-Alfv´en and CME-like conditions. Caveat: Low frequency 0 20 40 60 80 Tilt(deg) 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 P(1019erg/s) Sub-Alfvénic Magnetopause 0 20 40 60 80 Tilt(deg) 0.2 0.4 0.6 0.8 1.0 P(1019erg/s) Super-Alfvénic Magnetopause 0 20 40 60 80 Tilt(deg) 2.4 2.5 2.6 2.7 2.8 P(1019erg/s) Super-Alfvénic Bow Shock 0 10 20 30 40 Tilt(deg) 2 4 6 8 10 12 P(1021erg/s) CME Total Emission 0.64G 0.32G 0.16G 0.2 0.


3D Climate Modelling of TRAPPIST-1 c with a Venus-like atmosphere: Large-scale circulation and observational prospects D. Quirino1,2, G. Gilli1,3, T. Navarro4,5, M. Turbet6, T. Fauchez7,8, P. Machado1,21.InstituteofAstrophysicsandSpaceSciences(IA),Lisbon,Portugal(dfquirino@fc.ul.pt);2.FacultyofSciences,UniversityofLisbon,Lisbon,Portugal;3.InstituteofAstrophysicsofAndalusia(IAA–CSIC),Granada,Spain(gilli@iaa.es);4.TheMcGillSpaceInstitute,Montréal,QC,Canada;5.SpaceScienceInstitute,Boulder,CO,UnitedStates;6.LaboratoiredeMétéorologieDynamique/IPSL,CNRS,SorbonneUniversité,ÉcoleNormaleSupérieure,PSLResearchUniversity,ÉcolePolytechnique,75005Paris,France;7.NASAGoddardSpaceFlightCenter,Greenbelt,MD,UnitedStates;8.AmericanUniversity,Washington,DC,UnitedStates . IntroductionThe population of close-in Earth-sized exoplanets orbiting late-type M-dwarf stars has increased in the recent years (e.g., [1, 2]), creating an unique opportunity: best targets for terrestrial planets atmospheric studies. Methods Thermal Structure TRAPPIST-1 c atmosphere is warmer than Venus’s at and above the cloud deck region. The substellar and nightside equatorial profiles are similar from the ground to p ~ 0.01-bar. Between ~20-bar and ~ 0.01-bar, the nightside equatorial region [22.5º N/S] is warmer than the remaining nightside hemisphere, suggesting that a day-night heat redistribution mechanism is present in the equatorial region and throughout a significant atmospheric region. Thermal phase curves & transmission spectra Objectives Large-scale circulation Fig. 3. (Above) Time-averaged (10 orbits) temperature profiles for different regions of TRAPPIST-1 c, compared to the Venus International Reference Atmosphere (VIRA) profile. The red (blue) cross depict the approximate level of sulphuric acid condensation (freezing) point on Venus. Fig. 4. (Left). Zonal and time-averaged zonal wind field. The solid thick (thin) black lines represent isotachs with a 50 m/s (25 m/s) interval.Zonal circulation: eastward equatorial superrotationjet peaking 300 m/s in the uppermost levels of the atmosphere with a clear signature at the cloud top (p~37-mbar). Meridional circulation: two large cells, one per hemisphere (north and south), crossing the pole and redistributing heat f rom dayside to nightside. Fig. 5. (Above). Zonal and time-averaged mass streamfunctions: (a) dayside and (b) nightside. The integration exclude the terminators. Positive (negative) values, i.e., in red (blue), correspond to clockwise (anti-clockwise) motion. Fig. 6. (Left). Relation between thermal phase curves, outgoing long-wavelength radiation (OLR) and temperature fields. In the subplot a the red/blue arrows indicate the longitude corresponding to the orbital phase of peak emission, while the two-head arrow indicate each phase curve amplitude. Orbital phase 0 corresponds to the secondary eclipse, while πis the planetary transit. In subplots (b) and (c) the red/blue cross marks the longitude of the maximum peak emission over the equator. All data is time-averaged for ten orbits of TRAPPIST- 1 c.Fig. 7. (Above) Transit transmission spectra of TRAPPIST-1 c for JWST NIRSpecPrism (0.6 –5.3 μm) andMIRI (5 –20 μm) for: Venus-likeclouds(blue) andclear-sky(black), simulatedwiththePlanetarySpectrumGenerator . Different atmospheric levels can be surveyed with different thermal spectral bands: o CO2 absorption bands will sound mesospheric levels (p ~1-mbar) o Continuum bands will sound the cloud top (p ~ 37-mbar) CO2 absorption bands: larger amplitudes and later peak emission Smaller eastward hotspot offsetVenus-like clouds will screen almost all but the strongest CO2absorption bands in the transmission spectra. The 4.8-μm CO2might become detectable, which could indicate the presence of a high-pressure CO2 a tmosphere. We use the Generic-PCM initially developed by the Laboratoire de Météorologie Dynamique (Paris, France) for exoplanet and paleoclimate studies [13 - 15]. The Generic-PCM includes a dynamic


KDAR Neutrino Measurements with JSNS2 Johnathon Jordan for the JSNS2 Collaboration University of Michigan Poster #482 Proton Beam Linear Accelerator RCS MLF MLF Beam Layout Mercury Target When charged kaons decay at rest, they can produce monoenergetic neu- trinos from the two-body decay: These known-energy kaon de- cay-at-rest (KDAR) neutrinos can be used to make a variety of interesting physics measurements. KDAR Neutrino Proton Neutron KDAR Neutrino Neutrino-induced Nuclear Excitations Neutrino-Nucleon Interactions *Cartoon KDAR Neutrino Basics The MLF Neutrino Source KDAR neutrinos offer a standard candle to benchmark neutrino interac- tion models relevant for future oscilla- tion experiments [1]. Their intermedi- ate energy allows them to probe the transition between neutrino-nucleus and neutrino-nucleon scattering [2]. KDAR neutrinos can also be used for a variety of other measurements [3,4]. The J-PARC Material and Life Science Experimental Facility (MLF) is a spall- ation neutron source in Japan. A high intensity proton beam is accelerated to 3 GeV by the Rapid Cycle Synchrotron (RCS) and delivered to a liquid mercury target in the MLF. In addition to provid- ing a world-class spallation neutron source, the mercury target is also an intense source of decay-at-rest (DAR) neutrinos. The MLF design beam power is 1 MW and the beam power has been steadily increasing (in June beam power has been ~610 kW). The 3 GeV beam energy is high enough for kaons to be produced in the target where they quickly slow down and decay at rest. This fact combined with the high beam intesnity makes the MLF the best place in the world to do physics with KDAR neutrinos. 104 105 106 107 Neutrino Flux (Arb. Units) µ π K −600 −400 −200 0 200 400 600 800 1000 Time (ns) 0 20 Current (A) ×25 Hz Beam Pulses 0 100 200 300 -8 10 -7 10 -6 10 -5 10 -4 10 -3 10 -2 10 -1 10 Energy (MeV) ν/POT/2 MeV The JSNS2 Experiment Neutrino Flux + Timing θ 2 2 sin 4 − 10 3 − 10 2 − 10 1 − 10 1 ] 4 /c 2 [eV 2 m Δ 2 − 10 1 − 10 1 10 2 10 90%C.L 2 JSNS LSND 99%C.L LSND 90%C.L OPERA(2013) 90%C.L 1 MW x 3 years exposure 1 detector (17 tons ﬁducial) Protons are delivered to the MLF at 25 Hz in two pulses. Neutrinos from kaon decays are produced in time with the beam due to the short kaon lifetime. The low duty factor of the beam re- duces beam-off backgrounds to KDAR neutrino measurements. Most neutrino parents decay at rest in the target and shielding, so the result- ing neutrino ﬂux largely consists of well-understood decay-at-rest compo- nents. Thus, decay-in-ﬂight (DIF) neu- trino backgrounds to KDAR neutrinos are small. The J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source (JSNS2) [5] is a short baseline neutrino oscillation experiment. JSNS2 is de- signed to search for oscillations with ∆m2 ~ 1 eV2 using the double coincidence signature of IDB (prompt positron, delayed neutron capture). JSNS2 has collected 10 days of initial data this month (expected to contain 200-400 KDAR events) and will continue operation in the fall. JSNS2 utilizes a liquid scintillator (LS) neutrino detector consisting of an inner volume ﬁlled with gadolini- um-doped LS and outer buffer and veto regions ﬁlled with undoped LS. Scintillation light is collected by 120 10-inch PMTs including 24 PMTs in the veto region used to reject activity origi- nating outside the detector. There is additional shielding under the detec- tor to reduce environmental gamma backgrounds produced in the concrete hatch the detector sits on. KDAR Signatures in JSNS2 References + Acknowledgements                   Other JSNS2 Posters JSNS2 is most sensitive to KDAR neutri- no charged current interactions. In most events, the expected event sig- nature is a double coincidence be- tween the initial neutrino interacion products and the subsequent muon decay (lifetime ~2.2 μs): In ~20% of interactions, the ﬁnal state is also expected to con


Team design for team science Emerging Methods and Tools for Sparking New Global Creative Networks COINs15 Tokyo – Jeff Horon, Consultant, Elsevier Research Intelligence – http://jeffhoron.com Emerging methods and tools are changing the ways participants in global creative networks become aware of each other and proceed to interact. Some web-based resources intended to spark new collaborations in creative networks have been plagued by dependence on fragmented or out-of-date information, having shallow recall (e.g. limited to a list of manually curated keywords), offering poor interconnectivity with other systems, and/or obtaining low end-user adoption. Increased availability of information about creative network participants' activities and outputs (e.g. completed sponsored research projects and published results, aggregated into global databases), coupled with advancement in information processing techniques like Natural Language Processing, enables new web-based technologies for discovering subject matter experts, facilities, and networks of current and potential collaborators. Large-scale data resources and NLP allow modern versions of these tools to avoid the problems of having sparse data and also provide for deep recall across many disciplinary vocabularies. These are "passive" technologies, from the perspective of the network participant, because the agent must undertake an action to use the information resources. Emerging "active" methods and tools utilize the same types of information and technologies, but actively intervene in the formation of the creative network by suggesting connections and arranging virtual or physical interactions. Active approaches can achieve very high end-user adoption rates. Both active and passive methods strive to use data-driven approaches to form better-than-chance awareness among networks of potential collaborators. Recent case studies suggest the existence of repeatable strategies for facilitating data-driven matching and better-than-chance interactions designed to spark new global creative networks. Abstract Active / Interventional Networking Methods Passive Networking Suggested casual interactions at physical events and These emerging methods and tools suggest the existence of repeatable strategies for facilitating data-driven matching and better- than-chance interactions designed to spark new global creative networks. As these methods become further systematized and see wider adoption, they are poised to influence larger numbers of creative networks and their participants. Conclusions scheduled interactions at physical events Identification via mining network structures Outcomes Identification via survey / self-identification Arrange researchers and concepts into a self-organizing bipartite network Eliminate matches that already collaborate The remainder are suggested matches… …. with suggested conceptual connections Participants specify interests, expertise, and needs (often discipline-specific) Score potential matches Issue recommendations


Polyolefin Family Polymers for Drug Delivery Applications CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has recently expanded its low PDI polymer portfolio and announces its new offering of Polyolefin Family polymers with a wide range of properties that make them well-suited for a variety of drug delivery applications. Low dispersion index polymers are polymeric compounds with low molecular weight dispersion. Typically, the structures of such polymers are designed to reduce their dispersion in solution, thereby improving their stability and controllability. They’re widely used as drug carriers mainly because of their ability to efficiently carry and release drug molecules, thereby improving drug bioavailability and therapeutic efficacy. The design of such drug carriers also helps to overcome some of the limitations of conventional drugs such as biostability, water solubility and drug distribution in the body. The Polyolefin family is a class of polymers derived from simple hydrocarbons with a wide range of promising drug delivery applications. These materials, which include polyethylene and polypropylene, have a number of unique properties suitable for various pharmaceutical applications. For example, Polyolefins' inertness, biocompatibility, and ability to be tailored to specific drug release profiles make them particularly attractive for the design of drug delivery systems. In addition, Polyolefin-based drug delivery systems offer excellent stability, ensuring that drug formulations remain intact over time. The biodegradability and minimal toxicity of Polyolefins also make them attractive for the development of sustained-release formulations. Moreover, the tunable properties of Polyolefins allow modulation of drug release kinetics, resulting in precise control of the therapeutic dose. This family of polymers has proven advantageous in improving the efficacy and safety of drug release and overcoming the challenges associated with conventional formulations. As research continues, the Polyolefin family will continue to attract the attention of scientists and pharmaceutical experts, demonstrating its potential to revolutionize drug delivery strategies and improve patient outcomes. CD Bioparticles recognizes the potential of the Polyolefin family for pharmaceutical applications and has developed innovative drug delivery systems using Polyolefins based on their inherent properties. The company is committed to working with partners on a number of research and development projects aimed at delivering a variety of drugs using Polyolefins and bringing these novel drug delivery systems to market. Furthermore, CD Bioparticles strives to make further groundbreaking contributions to the field of drug delivery and will continue to honor its commitment to innovation.


Is AD Leo entering a polarity reversal? Long-term monitoring of the large-scale magnetic field with ESPaDOnS, NARVAL and SPIRou Stefano Bellotti1,3, Julien Morin2, Lisa Lehmann1, Pascal Petit1, Gaitee Hussain3 and the SLS consortium 1: IRAP, Toulouse (FR), 2: LUPM, Montpellier (FR), 3: ESA/ESTEC, Noordwijk (NL) stefano.bellotti@irap.omp.eu Acknowledgements: Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii. The observations at the CFHT were performed with care and respect from the summit of Maunakea which is a significant cultural and historic site. We gratefully acknowledge the CFHT QSO observers who made this project possible. We acknowledge funding from ANR of France (SPlaSH), with PI Xavier Delfosse. Fig 1. Evolution of Bl. Left: optical (circles) and near-infrared (squares) time series between 2006 and 2020. Right: near-infrared time series phase-folded at the stellar rotation period. FWHM of Stokes I ●FWHM useful activity tracer sensitive to Zeeman eﬀect → high Landé factor (geﬀ) lines can reveal activity signal ●Full vs high-geﬀ mask [12]: all FWHM values are larger in the latter case ●Constant vs sine ﬁt: the variations of the 2020b epoch are better described by sinusoid ﬁt (22% decrease in residual RMS) Longitudinal magnetic ﬁeld ●Disk-integrated, line-of-sight component of the magnetic ﬁeld (Bl) ●Stellar north pole is dominated by negative dipole all the time ●Global decrease in ﬁeld strength over 14 years ●Reduced axisymmetry indicated by varying amplitude in the phase-folded time series Fig 2. Phase-folded FWHM curves using full and high-geff masks for near-infrared epochs: 2019a (top), 2019b2020a (middle), 2020b (bottom) ●Increased FWHM variations imply lower degree of axisymmetry ●FWHM phase variations are reﬂected by ZDI maps Principal Component Analysis ●Apply PCA to mean-subtracted near-infrared Stokes V (2019-2020) to infer details on non-axisymmetric ﬁeld [13, see also poster of L. T. Lehmann] Zeeman-Doppler Imaging ●Reconstruction of the large-scale magnetic ﬁeld topology by means of a maximum-entropy algorithm Stellar magnetic cycles With a long-term monitoring of the large-scale magnetic ﬁeld, we can search for temporal evolution of the topology and uncover stellar dynamo theories. The Sun is an important benchmark: the magnetic cycle is characterised by a 11-yr variation in sunspot number, size and latitude of emergence, and magnetic polarity reversal [1,2]. Spectropolarimetric observations revealed analogous polarity ﬂips also on other stars [3,4]. At the lower end of the main sequence, M dwarfs represent excellent laboratories to study non-solar dynamo mechanisms underlying the generation and preservation of magnetic ﬁelds. Conclusions ●Variations in the coeﬃcients are more sinusoidal and ampliﬁed → large-scale ﬁeld is dipolar and its axisymmetry decreases over time Fig 3. Evolution of PCA coefficients for the first three eigenvectors over the near-infrared epochs: 2019a (top), 2019b2020a (middle) and 2020b (bottom). ●First three eigenvectors have signals → on average ﬁeld is non-axisymmetric Fig 4. Evolution of ZDI map over near-infrared epochs: 2019a (left), 2019b2020a (middle) and 2020b (right). The magnetic maps are in flat polar view, with the north pole at the center and the equator marked by a solid line ●The geometry is poloidal (magnetic energy fraction >90%) and dipolar (>70%), as in 2006-2016 observations ●Axisymmetry decreases from >85% to 48% in 2020b and tilt angle increases from 15o to 56o accordingly ●Decreasing axisymmetry of the large-scale ﬁeld conﬁrmed by diﬀerent techniques ●Global evolution of the large-scale ﬁeld of AD Leo possibly suggesting a magnetic cycle, in the strong aligned dipole category ●Diﬀerence of longitudinal and ZDI ﬁeld streng


Wake Forest University School of Medicine is the academic core of Atrium Health. • EPIC used to identify all sterile culture sites which grew Serratia Marscens or Liquifascens in our system • Queried 8/1/2016 - 4/15/2022 Julia Cook, MD; Matthew B Anderson, MD; Erin Barnes, MD, MS, FASAM. Infectious Diseases at Atrium Health Wake Forest Baptist Health A Case Series of Serratia Marcescens Infectious Endocarditis in Persons Who Inject Drugs Demographics Age (years) 29.5 Race N (%) Black 2 (9) White 20 (91) Gender Male 6 (27) Female 16 (82) HCV exposed 19 (86) Background Results • Serratia marcescens is a gram-negative bacillus that is widespread in the environment • Rare cases of endocarditis caused by this organism have been reported • Atrium Health Wake Forest Baptist (AHWFB) in North Carolina has experienced an increasing number of severe infections with Serratia marcescens, particularly in persons who inject drugs Methods Characteristics Bacteremia Duration xxxxx Substances Used N (%) Opioid Injected 16 (73) Stimulant Injected 3 (14) Stimulant Without Route Stated 10 (45) Blood Culture Serratia Only 16 (73) Polymicrobial 6 (27) Prior IE Episode 9 (41) Prosthetic Valve Present 4 (18) 9% 35% 43% 13% Valves Involved Aortic Mitral Tricuspid Pulmonic Complications Emboli N (%) Lung 10 (45) Cerebral 7 (32) Major Arterial 5 (23) Other Epidural abscess 1 (5) Septic Arthritis or Osteomyelitis 4 (18) Endophthalmitis 1 (5) Surgery and Disposition Surgery N(%) Aspiration 2 (9) Valve Repair 16 (73) Valve Replacement 3 (14) Disposition Deceased 4 (18) Left AMA 4 (18) Remained in AHWFB Facility for Duration 16 (73) Other† 2 (9) †One was transferred to another facility and one was discharged for daily infusions administered in an infusion center through peripheral IVs placed each day 284 • 693 reports representing 293 individuals • 9 removed for age less than 18 96 • 188 without evidence of injection drug use 42 • 54 did not meet criteria for at least possible endocarditis by Modified Duke Criteria 22 • Serratia was secondary to line infection • Serratia was not targeted for endocarditis treatment • Serratia was secondary to separate process • Injection drug use timeline not clear Discussion 9% 45% 5% 41% Final Regimen Deceased Beta-Lactam Alone Fluoroquinolone Alone Beta-Lactam + Fluoroquinolone • AHWFB has a large number of Serratia IE cases in PWID, the largest number reported in the US since a 1969-1974 series in the San Francisco Bay Area • Likely sources include contaminated tap water used for drug mixing • Further study to determine if this a regional or national trend is warranted as is study on the ideal treatment regimen


BIBLIOGRAPHICAL DATA WORKING GROUP For decades bibliographical information has been among the most widely-used resources in the humanities. “Bibliographical Data” Working Group aims to foster cooperation between all the parties involved in bibliographic data life cycle in the humanities, especially between data creators, curators, researchers, developers, and theorists of documentation and bibliography. Data preparation for advanced research Facilitating international data-based cooperation Methodological issues Publishing bibliographies Processing bibliographic metadata Remediation of bibliographical information Development of user-oriented services IF YOU INTERESTED IN THE WG, PLEASE CONTACT US: Tomasz Umerle: tomasz.umerle@ibl.waw.pl Vojtěch Malínek: malinek@ucl.cas.cz @bibliodataWG Bibliographical Data Landscape Analysis Report data production and use analysis challenges and opportunities for public stakeholders crucial stakeholders public and private dimensions of the landscape Goals for 2020: MISSION STATEMENT: bibliodata software bibliodata in research bibliodata and scholarly primitives Bibliographical Data Workflows - Workshop advocating for a joint public stakeholders agenda bibliodata and LOD subject bibliographies Web archiving discovery platforms for bibliodata AREAS OF INTEREST 25th November 14:00 MORE INFORMATION ABOUT THE WORKSHOP AT: https://dariah-ae-2020.sciencesconf.org/309669


SWEET-cat: The cat is still sweeter! A catalog of stellar parameters for stars with planets Sérgio G. Sousa et al. Instituto de Astrofísica e Ciências do Espaço & Centro de Astrofísica da Universidade do Porto Abstract: This is a story of two cats that discover that astronomers have presented a sweet cat. What is this sweet cat? Are there cats in other worlds? Is there something more, something else? Top left: The metallicity distributions for two different populations classified according to the higher planetary mass in the system: low-mass planet hosts (LMPH: 99 planet hosts), and high-mass planet hosts (HMPH: 771 planet hosts) with homogeneous parameters from SWEET-Cat. The mass separation value is 30 earth masses. The very well known metallicity correlation is very clear for massive planet hosts, while stars hosting only low massive stars seems to be no different from the general population of stars. Top right: The updated version of SWEET-Cat contains accurate determination of surface gravities (orange points) which are computed using GAIA astrometry and photometry. For details, please see Sousa et al. 2021. Bottom right: Using the updated homogeneous spectroscopic parameters listed in SWEET-Cat we can still find a correlation in the metallicity-period-mass diagram hinting that the mass of planets increase with the period and the metallicity. This trend cannot be fully accounted by observational bias as demonstrated in Sousa et al. 2019. References: Sousa, S.~G., Adibekyan, V., Delgado-Mena, E., et al.; 2021; A&A, 656, A53. doi:10.1051/0004-6361/202141584 Sousa, S.~G., Adibekyan, V., Santos, N.~C., et al.; 2019; MNRAS, 485, 3981. doi:10.1093/mnras/stz664 Sousa, S.~G., Adibekyan, V., Delgado-Mena, E., et al.; 2018, A&A, 620, A58. doi:10.1051/0004-6361/201833350 Andreasen, D.~T., Sousa, S.~G., Tsantaki, M., et al.; 2017, A&A, 600, A69. doi:10.1051/0004-6361/201629967 Sousa, S.~G., Santos, N.~C., Mortier, A., et al.; 2015, A&A, 576, A94. doi:10.1051/0004-6361/201425227 Santos, N.~C., Sousa, S.~G., Mortier, A., et al.; 2013, A&A, 556, A150. doi:10.1051/0004-6361/201321286 Acknowledgments: Sérgio G. Sousa aknowledges the support from FCT through Investigador FCT contract nr. CEECIND/00826/2018 and POPH/FSE (EC). Check our last paper:


1 Georgia State University, 2 European Space Agency, 3 University of Hawaii Varun Chaturmutha1, Bernhard Fleck2, Stuart Jefferies1,3 Probing the Atmosphere of the Sun-As-A-Star Using Seismic Waves varun@astro.gsu.edu (2a) Layer Separation (2b) Sound Speed (2e) Sunspot Number (1a) Solar Surface-Resolved Data (8 hours) (1b) Sun-as-a-Star Data (1 Year) We use multi-height, line-of-sight Doppler velocity observations of the Sun, as if it were a distant star, to probe the properties the solar atmosphere via travel-time analysis of acoustic-gravity waves. Travel time data from surface-resolved observations of the Sun (1a) have been used historically to estimate atmospheric properties via wave models [1,2,3]. We transfer this technique to sun-as-a-star data (1b) to estimate separation between the observed layers (2a), sound speed (2b), radiative cooling time (2c), and the horizontal wavenumber (2d). (2c) Radiative Cooling Time (2d) Horizontal Wavenumber Website: astro.gsu.edu/~varun Linkedin: vchaturmutha Email: varun@astro.gsu.edu The atmospheric properties estimated using Sun-as-a-star data matches closely with surface-resolved observations of the Sun. The temporal evolution of atmospheric properties (2a, 2b, 2d), is strongly correlated with the solar cycle (2e) of the Sun. This suggests the potential of this technique to probe properties of stellar atmospheres and an alternate method to detect stellar cycle effect. The layer separation between multi-height spectra observations could enable astroseismic tomography of stellar atmospheres, radiative cooling times have implications for atmospheric heating, sound speed offers insights into the temperature structure, and horizontal wavenumber is related to the granular scales. Figure 1: Travel time spectra prepared using (a) surface resolved and (b) Sun-as-a-star, doppler velocities from Na D and Fe I spectral lines. Sun-as-a-star travel time in (b) is prepared by averaging 4 hours of data over 365 days. Figure 2: Temporal evolution of sin-as-a-star atmospheric properties: (a) separation between observing levels, (b) sound speed, (c) radiative cooling time, and (d) horizontal wavenumber. The Sunspot cycle evolution is shown in (e) as a proxy for magnetic activity on the sun. 1) Souffrin, P. 1972, A&A, 17, 458 2) Jefferies, S. M., Fleck, B., Murphy, N., & Berrilli, F. 2019, ApJL, 884, L8 3) Chaturmutha, V., Fleck, B., & Jefferies, S. M. 2024, ApJ, 966, 200 4) Pesnell, W. D., Thompson, B. J., & Chamberlin, P. C., 2012, SoPh, 275, 3 5) Scherrer, P. H., Schou, J., Bush, R. I., et al. 2012, SoPh, 275, 207 6) Forte, R. et al. 2018, in IAU Symp. 335, Space Weather of the Heliosphere: Processes and Forecasts, (Cambridge: Cambridge Univ. Press), 335 INTRODUCTION DISCUSSION DATA ANALYSIS R E S U L T S REFERENCES


ASSESSMENT OF LOOP-MEDIATED ISOTHERMAL AMPLIFICATION ASSAYS FOR ESCHERICHIA COLI DETECTION Mila Djisalov1, Ljiljana Šašić Zorić1, Ljiljana Janjušević1, Teodora Knežić1, Ivana Gadjanski1 1University of Novi Sad, BioSense Institute, Dr Zorana Đinđića 1, 21000 Novi Sad, Serbia Corresponding author: mila.djisalov@biosense.rs INTRODUCTION: As of lately, loop-mediated isothermal amplification (LAMP) has become a powerful alternative to the polymerase chain reaction (PCR) in the molecular diagnostic world, especially for pathogen detection in clinical and food samples. LAMP is a powerful and new method of nucleic acid amplification, with the ability to detect DNA at a very low level. In comparison to other molecular methods such as PCR and Real-Time PCR, LAMP eliminates the need for sophisticated thermal cyclers. High efficiency of DNA amplification by LAMP significantly shortens the whole amplification process. OBJECTIVES: This study aims to assess the efficacy of two different LAMP kits, WarmStart (Real-Time LAMP) and Colorimetric LAMP in detection of Escherichia coli. We tested and optimized the kits for the detection of E. coli ATCC® 25922 directly from bacterial suspension and indirectly using bacterial genomic DNA (gDNA). LAMP results were then compared with the results of E. coli detection using standard PCR methodology. METHOD / DESIGN: For use in LAMP detection of E. coli directly from the bacterial suspension, we prepared eight bacterial dilutions in concentrations ranging from 1.5x108 - 1.5x101 CFU/mL. All bacterial dilutions were then used for LAMP detection using WarmStart Colorimetric LAMP 2X Master Mix (New England BioLabs) for colorimetric LAMP and WarmStart LAMP Kit (New England BioLabs) for Real-Time LAMP. Real-Time LAMP reactions were done on the Genie® II, an instrument for isothermal nucleic acid amplification (Figure 1). LAMP primers (F3, B3, FIP, BIP, LF, BF) (Figure 2) for the malB gene are taken from the literature. For indirect detection we extracted genomic DNA from E. coli using GeneJET Genomic DNA Purification Kit (Thermo Scientific). Extracted gDNA with the concentration 50 ng/μl was used for preparation of ten-fold dilutions (10-1 - 10-4), and these dilutions were used in both Colorimetric and WarmStart LAMP assays in order to compare limits of detection with and without DNA extraction. Finally, we used E. coli genomic DNA serial dilutions for standard PCR, using F3 and B3 primers for malB gene. RESULTS: The results showed that both LAMP methods (WarmStart and Colorimetric LAMP) enabled the detection of E. coli directly, in suspension (without prior DNA isolation) for bacterial concentration of 1.5 x 108 CFU/mL (Figure 3, Chart 1). Additionally, the results of Colorimetric LAMP using serial dilutions of E. coli gDNA showed detection in all tested concentrations, except the lowest (10-4) (Figures 4-5). On the other hand, the WarmStart LAMP kit enabled E. coli gDNA detection in all tested gDNA dilutions (Chart 2, Figure 6). The conventional PCR methods failed to detect E. coli malB gene product for the lowest DNA concentration (Figure 7.). Additionally, DNA bends on agarose gels are more intensive in the LAMP products compared to those obtained with PCR products. CONCLUSIONS: Presented research showed the incredible power of the LAMP methodology (both, Colorimetric and Real-Time) to detect E. coli even without prior isolation of bacterial gDNA. Also, LAMP enabled E. coli detection even at an extremely low concentration of tested gDNA (50 x 10-4 ng/μl), while with conventional PCR that was not the case. PCR managed to detect bacterial gDNA up to a concentration of 50 x 10-3 ng/μl. Based on these results, LAMP was proved to be more sensitive than PCR, with a large capacity to be used in molecular diagnostics. Also, LAMP is easier to handle since it is more time-efficient and can be performed using portable small devices suitable for on Point-of- Care (POC) research. Figure 1. Genie® II instrument for Real-T


The Bering Sea Project Archive: a Prototype for Improved Discovery and Access Don Stott, Matthew S. Mayernik, Michael D. Daniels, James A. Moore, Steven F. Williams, and John Allison NCAR Earth Observing Laboratory, Boulder CO, USA, stott@ucar.edu Science-focused use case examples • Identify a geospatial region via data where certain parameters show specific features. • Ex. #1: Find the areas in a defined region where benthic biomass is high for walruses to feed • Ex. #2: Is the line between benthic and pelagic dominated ecosystem shifting? • Find information (data, publications, products) related to a geolocated event. • Ex. #1: Information related to a ship cruise • Ex. #2: Information relevant to under ice CTD data collected in the South Bering Strait vivo.eol.ucar.edu The Earth Observing Laboratory (EOL), as a partner in the NSF funded EarthCollab project, is using linked open data to support scientific collaboration and increase the discoverability and usability of scientific resources. The EOL proof-of-concept Arctic Data Connects web application interlinks datasets from the Bering Sea Project Archive at EOL across platforms and projects. It provides researchers the means to more easily find people, organizations, and resources that are relevant to their work, via semantic and linked data. The Bering Ecosystem Study (BEST) was an NSF sponsored program that provided researchers an opportunity to gain an improved understanding of the linkages between variations in Bering Sea ice cover and the biology of the waters and benthos beneath. A collaborating program, the Bering Sea Integrated Ecosystem Research Program (BSIERP), sponsored by the North Pacific Research Board, collected data in the same region at the same time in an effort to improve understanding and prediction of ecosystem changes related to anthropogenic and natural causes. Over the six-year period of the programs hundreds of multidisciplinary datasets from a variety of instrumentation and measurement platforms within thirty-one categories of research were processed and curated by the NCAR/EOL. The separate BEST and BSIERP data archives were brought together to form the Bering Sea Project Archive in 2010. The EOL organized and continues to maintain the Bering Sea Project Archive as the single source for all data from the combined efforts of the BEST and BSIERP programs. The Bering Sea Project Archive incorporating the BEST-BSIERP Data Archives http://beringsea.eol.ucar.edu Data Linkage with Derived Datasets NSF award numbers are used here to connect datasets and Principal Investigators. As more datasets receive DOIs (Digital Object Identifiers), the DOI will be utilized to link derived products. EarthCollab Data Structures Build ontology extensions for linking: • VIVO-ISF: People, organizations, publications • DCAT: data sets and catalogs • GCIS: Scientific instruments, platforms, projects • Local ontology development to fill gaps Yet to model: • Geospatial and temporal features • Parameters/variables • Use case specific features, e.g. ship tracks EarthCollab is funded by the US National Science Foundation EarthCube program, grants #1440293, 1440213, 1440181, PIs Matthew Mayernik, Mike Daniels, Dean Krafft, and Linda Rowan. Underlying Technology The heterogeneous products of oceanographic field programs such as the Bering Sea Project challenge the ability of researchers to identify which data sets, people, or tools might be relevant to their research, and to understand how certain data, instruments, or methods were used to produce particular results. Arctic Data Connects is employing the open-source semantic web software, VIVO, as the underlying technology to connect the people and resources of virtual research communities. VIVO is being leveraged to address connectivity gaps across distributed networks of researchers and resources and to identify relevant content, independent of location. http://vivoweb.org


Plataforma para la creación de servicios elásticos big data analytics en la nube Este proyecto ha sido financiado por IVACE y FEDER, a través de la convocatoria de ayudas dirigidas a centros tecnológicos de la CV para proyectos de I+D en cooperación con empresas 2017, 2018 Y 2019 (IMDEEA/2017/139, IMDEEA/2018/94 y IMDEEA/2019/77) Cada vez más empresas están adoptando soluciones de Big Data Analytics. Actualmente existen herramientas gratuitas y de código libre, pero la complejidad de las mismas requiere que sean servicios ofrecidos por centros especializados. Durante 2019, el proyecto Radiatus III continua los trabajos iniciados en 2017 y 2018, avanzando en la investigación, diseño y prototipado de servicios elásticos de Big Data Analytics (BDAaaS) en la nube sobre la plataforma ECloud - Platform as a Service (PaaS), para el tratamiento de datos en tiempo real (Streaming). El proyecto avanzará en soluciones al gran reto que plantea la complejidad de tratar y analizar grandes cantidades de datos recopilados a través de diferentes fuentes y adquiridos en tiempo real, el llamado Big Data Streaming Analytics. A través de estas soluciones las empresas podrán centrarse en el análisis de los datos sin perderse en la complejidad de la infraestructura Big Data necesaria para tal fin. Al finalizar el proyecto, se habrá creado un servicio de Big Data Streaming Analytics en el ecosistema de Radiatus al servicio de las empresas TIC de la Comunitat Valenciana Primera versión del orquestador de servicios con funcionalidades básicas, para el uso en modo "multitenant" del mismo Mejora de la arquitectura y servicios para mejorar su funcionalidad, tolerancia a fallos, rendimiento, seguridad y accesibilidad. Incorporación de nuevas tecnologías Desarrollo de un prototipo de servicio para la plataforma Ecloud , que permita el procesamiento distribuido de modelos de aprendizaje automático


DNA, the genetic blueprint of life, is targeted by a multitude of damaging species of both internal and external origin. This damage can result in the loss of genomic integrity and increase susceptibility to immunodeficiency, neurological disorders, and cancers. Sophisticated DNA repair mechanisms, such as base excision repair, have evolved to correct the damaged DNA and restore genomic integrity. However, errors within these repair mechanisms can result in mutagenic events. Base excision repair, initiates via the use of a DNA glycosylase. Overactivity of alkyladenine glycosylase (AAG), an example of a DNA glycosylase, can result in accumulation of toxic abasic sites that result in mutagenic events and cause cell death. The design and synthesis of a highly active inhibitor of AAG is required. Herein, the rationale behind the design of azanucleoside mimics of such an inhibitor is described, followed by their synthesis. Additionally, development, optimisation, and application of an AAG inhibitory bioassay will provide some of the key structural activity relationships to allow determination of the feasibility of using these inhibitors as therapeutic agents.


A major hypoxic blackwater event occurred in 2016 in response to large unregulated flood events in rivers of the southern Murray-Darling Basin.  Caused by extensive overbank floods inundate floodplains where large quan- tities of organic matter (e.g. leaf litter/grass) had accumulated.  Dissolved organic carbon (DOC) is leached from organic matter and a propor- tion of that DOC is consumed by bacteria which, at the same time also con- sume dissolved oxygen (DO).  During the 2016 floods, consumption of DO by bacteria resulted in severe oxygen depletion (hypoxia) in rivers throughout the river system. MMCP Collaboration Factors Contributing to the 2016 hypoxic blackwater event Centre for Freshwater Ecosystems Fact Sheet Management of future events  Identify those areas of the floodplain that are likely to make the greatest contribution to organic matter loads (and hence blackwater).  Implement more regular inundation of those areas to try and reduce organ- ic matter loads on a more regular basis.  Optimize strategies to mitigate impacts on biotic communities (e.g. fish, crayfish).  Providing environmental water at locations that provide refuge.  Timing of environmental water, to provide refuges for biota at appropriate locations in the Murray-Darling Basin. Contact Centre for Freshwater Ecosystems La Trobe University P: + 61 2 6024 9650 E: cfe@latrobe.edu.au W: latrobe.edu.au/freshwater-ecosystems Further information MMCP Collaboration (MMCP) is a project supported by the Joint State Governments and the Murray-Darling Basin Authority to generate and adopt freshwater ecological knowledge through collaboration, to maintain research capability and contribute supporting science to underpin the Basin-Wide Watering Strategy. Full report: doi.org/10.26181/5d199d3ce698a This synthesis paper is a response to a question poised by the Murray-Darling Basin Officials Committee (BOC) in 2017, in relation to a hypoxic blackwater event that occurred in 2016. The objectives of this theme within the MMCP is to help the BOC address specific questions as they arise. These question will have relevance to the on-going management of Basin Assets. Version 2, July 2019 This project is supported through the Murray-Darling Basin Joint Governments Project team Gavin Rees - CSIRO Land & Water, Albury NSW Causes of blackwater


ေလ့လာမ&'ပီးဆံ-းသွား'ပီးေနာက် ဘာြဖစ်မလဲ? (လ"ငယ်များအတွက်လမ်း./န်မ1တစ်ခ4) သင့်ရဲ့ပ(းေပါင်းပါဝင်မ.သည်စစ်ေဆးေမးြမန်းသ(ေတွအ ေနအားြဖင့်သင့်ဆီမ:သတင်းအချက်အလက်ေတွကိ@ ြပည့်ြပည့်စံ@စံ@ရB:ိသွားသည့်အချိန်မ:ာCပီးဆံ@းသွားမည် ြဖစ်သည်။ ေလ့လာမ.မ:ာတစ်စိတ်တစ်ပိ@င်းပါဝင်ေပးြခင်းအားြဖင့် ေကျးဇ(းတင်ပါသည်။သင်၏ပ(းေပါင်းပါဝင်မ.သည် အြခားေသာသ(များအတွက်က(ညီရာေရာက်ပါသည်။ MRCTCENTER.ORG/FOR-KIDS ေလ့လာမ&တွင်က,န်ေတာ်/က,န်ေတာ်မတိ/ ့၏ပါဝင် မ&4ပီးဆံ/းသွားသည့်ေနာက်ဘာေတွဆက်ြဖစ်မ?ာလဲ ? သင့်ကိ'မေမ့ပါဘ-း!သင်/0င့်ေလ့လာမ3လ'ပ်ငန်းစ6 တွင်ပါဝင်သည့်ဝန်ထမ်းများသည်ေနာက်ဆက်တွဲ ထွက်ေပ?ေလာမည့်ေမးခွန်းA0ိေသာ်အချင်းချင်း ဆက်သွယ်/ိ'င်ပါေသးသည်။ပံ'မ0န်ေဆးက'သမ3အ တွက်သင်ကိ'ယ်တိ'င်သင့်ဆရာဝန်/0င့်ေတွGရပါလိမ့် မည်။ ေလ့လာမ3ကအြခားေသာသ'ေတသနတွင်ပါဝင်သ- များအတွက်ဆက်လက်လ'ပ်ေဆာင်/ိ'င်ပါေသး သည်။စံ'စမ်းစစ်ေဆးသ-ေတွကသ-တိ' ့လိ'အပ်ေသာ အချက်အလက်အားလံ'းကိ'စ'ေဆာင်းသွားIပီးေသာ် ြငားလည်းသတင်းအချက်အလက်ေတွကိ'စ'စည်း Iပီးမည်သည့်အေKကာင်းအရင်းဆိ'လိ'ချက်အဓိ ပMာယ်ကိ'အေြဖA0ာမIပီးမချင်းေလ့လာမ3ကမIပီးဆံ'း ေသးပါ။


United States Environmental Protection Agency Office of Research and Development -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 2 0 0 h N O G - R O C K In h . - Y 2 7 6 3 2 -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - N o tc h In h . - D A P T % C o n C a s p a s e 3 /7 -G lo % C o n C e llT ite r-G lo -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - R O C K In h . - Y 2 7 6 3 2 -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - E R K 1 /2 In h . - S C H 7 7 2 9 8 4 -1 0 -9 -8 -7 -6 -5 -4 -3 0 5 0 1 0 0 1 5 0 2 0 0 A p o p to s is - P K C In h . - B IS -1 BMPR Notch EGFR Wnt PPAR-y COX-2 mTORC PDGFR PKC RHO EP1-4 CREB AKT ETC I EGFR NO-cGMP ROCK Protein HDAC PARP1 ERK/MAPK p38/MAPK hNP1 Apoptosis Active Selective hNP1 Proliferation Active/Cytotoxic h. Neurite Outgrowth Inactive r. Neurite Outgrowth Awaiting Data Cortical Synap. To be tested Network Formation 7 3 4 5 6 8 9 1 2 -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 2 0 0 2 5 0 1 5 1 1 6 M K -2 2 0 6 m T O R C In h . -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 rN O G - C O X -2 In h . - C e le c o x ib -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 rN O G - E R K 1 /2 In h . - S C H 7 7 2 9 8 4 P331 %control %control %control %control %control %control %control %control -1 0 -9 -8 -7 -6 -5 -4 0 5 0 1 0 0 1 5 0 rN O G - A K T A c t. - S C 7 9 • The DNT battery captures some important and highly conserved signaling pathways associated with various processes involved in neurodevelopment. • Specifically, we demonstrated that: • Wnt, mTORC, PKC, and PDGFR pathway modulators have selective effects on neurite outgrowth. • ERK1/2, AKT, and COX-2 pathway modulators demonstrated non-selective effects on neurite outgrowth. • To date, ROCK, NO-cGMP, and COX-2 do not seem to play a significant role in our assays. Future Directions: • Ten chemicals remain to be tested in the battery. • After all chemicals have been tested, a concentration-response analysis will be performed using the ToxCast pipeline. • If we find that developmentally relevant biology is not being adequately recapitulated in the battery, we may explore incorporating other assays that include these pathways. Preliminary ToxCast Analysis Discussion References • These results work in conjunction with the full OECD DNT battery developed in collaboration with global partners. • Our work expands upon previous in vitro DNT pathway characterizations especially when it comes to neurite outgrowth¹, demonstrating that our battery is sensitive to Wnt, PKC, PDGFR, and mTORC disruption. • A more robust characterization of the biology captured by our assays will aid in the interpretation of results gathered using the DNT battery. * The views expressed in this poster are those of the author(s) and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. • The current NOG data (15 chemicals) has been analyzed using ToxCast R package tcplfit2 (v0.1.6). The computed AC₅₀ for each chemical and endpoint are given in the figure below. • The color scale indicates selectivity, which is determined as the ratio between the cytotoxic AC₅₀ and the AC₅₀ for the endpoint of interest. • Eventually, the AC₅₀ for each chemical and endpoint in the DNT battery will be computed, showing which pathways are best covered by the DNT battery and where improvements are needed. rNOG Neuron count Neurite count per neuron Neurite length per neuron Branch points per neuron DAPT-Notch Inh. ODQ-NO-cGMP Inh. Pioglitazone-HCl PPAR-y IWP2-Wnt Inh. Y-27632 ROCK KG-501-CREB Inh. AG1478-EGFR Inh. Celecoxib-COX-2 Inh. SCH772984-ERK1/2 Inh. SC79-AKT Act. MK-2206-mTORC Inh. CP-673451-PDGFR Inh. MHY1485-mTORC Act. BIS-1/BIM-1-PKC Inh. CHIR99021-Wnt Act. Computed 𝑨𝑨𝑨𝑨𝟓𝟓𝟓𝟓 AC₅₀: Concentration (µM) at which 50% maximum activity is observed. Endpoint Selectivity Ratio Selective Non-selective 3 1 Conclusions Selectivity Ratio = 𝐴𝐴𝐴𝐴50𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶 𝐴𝐴𝐴𝐴50𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸𝐸 ≥ 3, Selective Effect 1. Masjosthusmann


Sourajit Dey Department of Agronomy, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, West Bengal - 741252, India. “I wish to double the income of farmers by 2022 when India will celebrate 75 years of its independence.” PM Narendra Modi while addressing farmers rally at Bareilly (Feb 28, 2016) “Over the last seven years, the Government of India has taken many initiatives for transforming agriculture. From better irrigation to more technology, more credit and markets to proper crop insurance, focus on soil health to eliminate middlemen, the efforts are all encompassing.” PM Narendra Modi addressing at the webinar on PM-Kisan’s 2nd anniversary (Feb 23, 2021) Not only the farm incomes (i.e. output or the income of the sector or the value added or GDP of agriculture sector) but also the income of farmers. REAL INCOME not NOMINAL INCOME Nominal income can be defined as the income expressed in monetary terms and measured in current currency (in India its Rupee). Real income can be stated as the income of individuals or nations after adjusting for inflation.Real income = Nominal income –Inflation Reduction in arable land. Lower crop yields. Low consumption of pesticides leading to increase in pest attack. Fig- 1 Yields of major crops (tons/ha), 2017 Fig 2- Per capita consumption of pesticides (kg/ha), 2016 Lack of short duration HYVs. Higher cost of production. Imbalance in application of chemical fertilizers. Low Farmers’ Income. Lower irrigation efficiency. Low storage and processing facilities. Lack of marketing facilities. Primitive way of farming. A huge marketing margin taken by middlemen. Fig-3 Percentage of Farm households below poverty line Boost Crop productivity through better technology & increased use of quality seed, fertilizer and irrigation and crop-protection chemicals Incentive structure in the form of remunerative prices of some crops and subsidies on farm inputs Public investments in agriculture Building institutions Crudely, increase in area and productivity can be two major options to increase the agricultural output. Quality seeds (Improving seed replacement rate). Focus on irrigation along with adequate resource building (‘Per Drop More Crop’). Soil-test based nutrient management (Distribution of soil health cards). Opting normal sowing (to take the advantage of the weather anomalies). Pulses as a candidate crop (Pulses in a crop rotation can scale the per unit productivity, diminish the cost of production). Adopting the recommended package of practices (region specific). Supplementing soil with micro-nutrients (like Mn, S, Zn and Fe; if deficient). Use of more bio-fertilizers, vermi-compost and FYM in addition to chemical fertilizers. Post-harvest crop losses (Large investments in warehousing and cold chains). Diversification towards high value crops (Introduction, adaptation and acceptance of new varieties as well as new and upcoming production technologies). Crop protection chemicals are used during both pre-sowing & sowing, post sowing stages of farming. Food crops must compete with 30,000 species of weeds, 3,000 species of nematodes and 10,000 species of plant-eating insects. We know that despite the use of modern crop protection products 20-40% of potential food production is still lost every year to pests. To increase crop yields, continuous improvement of agricultural technologies is required to minimize crop losses. INTEGRATED PEST MANAGEMENT (IPM) Prevention:- Prevention can be done through- Location of crops (best suited to climate, soil, topography) Selection of crop variety (choosing beneficial crop varieties) Crop planting and rotation Soil management Water management Monitoring:- Tools like- pheromone traps, diagnostics and forecasting systems can assist in monitoring. Geographic information systems and remote-sensing techniques can also assist in area wide management. Intervention:- Intervention can be done through- Cultural and physical methods Biolo


Problem statement Awareness raising seminars Organised by each partner (7 EU Member States), bringing together different stakeholders in the field of migration and child protection Objectives • Raising awareness of the challenges in the field of international family law, migration and refugee law • Collecting feedback and best practices Transnational roundtables Organised by Ghent University and one partner (Münster, Versailles and Milan) Objectives • Improving uniformity of procedures applied to migrant children within the EU, including guardianship decisions, child marriage and kafala • Creating and strengthening sustainable networks between migration law, private international law and (international) family law authorities and organisations in different EU Member States Bookon thechild’s best interest in cross-border civil cases International conference 24-25 June 2024, Brussels Buildingnetworks Collecting empirical data Main objectives Connecting International Family Law and Migration Law Enhancing the Child’s Best Interest in Cross-Border Cases More info: https://famimove.unimib.it/# Belgian partner FAMIMOVE: jinske.verhellen@ugent.be leontine.bruynen@ugent.be geertrui.daem@ugent.be ▪Deficits in the protection of children and family relationships in a cross-border context ▪Migration and asylum authorities, civil servants, judges, welfare services have too little knowledge of private international law instruments and their coordination with EU- and national migration law


Heracleum sosnowskyi Brânca ursului Familia Apiaceae, Clasa Magnoliopsida SPECII CU ASPECT SIMILAR Foto & illustration credit: Kus Veenvliet, J., P. Veenvliet, M. de Groot & L. Kutnar (eds.). 2019. A Field Guide to Invasive Alien Species in European Forests. Nova vas: Institute Symbioisis, so. e.; Ljubljana: The Silva Slovenica Publishing Centre,Slovenian Forestry Institute. https://species.biodiversityireland.ie/proﬁle.php?taxonId=187116 Frunze submerse Heracleum mantegazzianum 1-3 m Plantă bienală sau perenă, cu o înălțime de 100-300 cm. Tulpina este brăzdată cu pete purpurii și cu perișori. Frunzele, pe fața superioară sunt lipsite de perișori, iar pe fața inferioară prezintă perișori ﬁni. Marginile frunzelor au dinți scurți și rotunjiți. Frunzele inferioare sunt împărțite în trei segmente ușor divizate în părți ovale, scurt ascuțite. Florile sunt albe, uneori rozalii, organizate în umbele compuse, ușor convexe de 30-50 cm. Fructele au formă ovală, sunt dens păroase atunci când nu sunt coapte. Fructele mature sunt aripate, cu numeroși spini situați pe mici umﬂături sferice sau ovoidale Tulpina Fructe Heracleum mantegazzianum se distinge prin dimensiunea sa, ﬁind printre cele mai mari plante erbacee din Europa. Poate crește până la 4-5 m înălțime. Heracleum persicum are, în general, 1,5-2,5 m înălțime. În special frunzele și semințele au un miros asemănător anasonului. Heracleum persicum Specie de interes pentru UE


LO Feynman diagrams for the canonical single top production modes; a) s-channel, b) t-channel, c) tW. Single top quark production – Top quarks at the LHC are produced predominantly via QCD with t partner, – Can be produced singly via EW interactions. Why do we study them? – Direct probes of Vtb and therefore sensitive to new physics, – Background to many searches, – Can constrain PDFs, – Provides measurements of top quark properties. tW production Latest cross section measurements of the tW process at CMS Duncan Leggat Fudan University, Shanghai Dilepton channel Lepton plus jets channel LP2021 – January 22 Duncan Leggat (Fudan University) [1] Higher-order corrections for tW production at high-energy hadron colliders, N. Kidonakis and N. Yamanaka, JHEP 05 (2021) 278, arXiv:2102.11300. [2] Observation of associated production of a single top quark and a W boson, CMS Collaboration, arXiv:1401.2942v2. Inclusive cross section Differential cross sections Diagram Removal vs Diagram Subtraction – tW at NLO interferes with tt and makes simulation difficult, – DR (default scheme) removes diagrams from signal definition, – DS (treated as a systematic) subtracts a gauge invariant term. First observation of tW production [2] The associated production of a single top quark with a W boson Major backgrounds ● tt – shares diagrams with tW at NLO (see below), ● Drell-Yan (dilepton channel), ● QCD and W+jets (lepton + jets channel). Event signature ●2 leptons (muon/electron), ●Associated MET, ●1 jet from a b quark. Event signature ●1 lepton (muon or electron), ●Associated MET, ●3 jets, 1 from a b quark. Analysis strategy ●36 fb-1 pp collision data collected in 2016 by CMS at √s = 13 TeV, ●Data-driven estimation used for QCD background, ●BDT to discriminate between tW and tt background, ●Binned likelihood fit on BDT output to extract tW production cross section. Result Measured cross section: 89 ± 4 (stat) ± 12 (syst) pb First observation of tW in the l+jets channel Leading uncertainties: – JES, data-driven background estimations, tt simulation SM cross section (aN3LO): 79.5+1.9 -1.8 (scale) +2.0 -1.4 (PDF) [1] Analysis strategy ●36 fb-1 pp collision data collected in 2016 by CMS at √s = 13 TeV, ●Using most sensitive eμ channel, ●BDT to discriminate between tW and tt background in 1j1t and 2j1t regions, ●Binned likelihood fit on BDT output and subleading jet pt in 2j2b region to extract tW production cross section. Measured cross section: 63.1 ± 1.8 (stat) ± 6.4 (syst) ± 2.1 (lumi) pb Leading uncertainties: – JES/JER, – Object selection and reconstruction efficiencies, – tt simulation JHEP10(2018)117 CMS PAS TOP-19-003 - CDS record 2712818 JHEP11(2021)111 A fiducial region is defined enriched in tW signal to extract differential measurements. Selected events pre- and postfit Single top quark cross sections measured by CMS


(pronounced nm-archive) is a FAIR and Open,Consensus-Driven Nuclear Magnetic Resonance (NMR) Data Repository and Computational platform. https://nmrxiv.org Journal of Natural Products 2023 – New NMR Data Requirements recommends NMR data deposition in nmrXiv for new compounds reported in J. Nat. Prod. Articles. nmrXiv: A FAIR and Open, Consensus-Driven NMR Data Repository and Computational Platform V. Nainala, Jena/DE, N. Sharma, Jena/DE, N. Rayya, Jena/DE, S. Kuhn, Tartu/Estonia, J. Liermann Mainz/DE, S. Neumann, Halle/DE, O. Koepler, Hannover/DE, C. Steinbeck, Jena/DE Aims and Objectives Software development To develop a voluntarily FAIR, cloud-based infrastructure that uses freely shared source code and deployment methods. Apply industry-grade development practices to ensure platform reliability, safety, and efﬁcacy. Submission, Curation and Analysis Enable the FAIR Sharing of raw NMR data to enhance the quality of chemical research and dissemination. Also, to develop non-prescriptivist curation and analysis standards for data and metadata. Build standards with input and contributions from the community and make them compatible with existing and potential newly developed formats and approaches. Training To engage analytical chemistry researchers and adjacent communities through webinars, workshops, tutorials, and community calls to ensure that nmrXiv meets the researchers’ needs and implements adequate incentive mechanisms for data contributions and curation. Documentation https://docs.nmrxiv.org Data submissions https://nmrxiv.org Submission Process ~ https://nmrxiv.org Data Backups and RDM FAIR & Open Source Documentation nmrXiv aims to enable the FAIR Sharing of raw NMR data to enhance the quality of chemical research and dissemination. Also, to develop non-prescriptivist curation and analysis standards for data and metadata. Build standards with input and contributions from the community and make them compatible with existing and potential newly developed formats and approaches. NMRium is an open-source NMR spectra visualisation and processing tool and a key integral part of nmrXiv. ●Handles 1D & 2D Spectra. ●Smart Peak Picking. ●Supports various ﬁle formats such as JCAMP-dx, Bruker and JOEL output and NMRedata. ●Handles molecular structures. ●Open source - https://nmrium.org nmrXiv data is equipped with robust data backup plan to recover the data in case of disaster. helpdesk@nfdi4chem.de info@nmrxiv.org Data versioning and multi-site disaster recovery ensure data availability and facilitate recovery during server failures, accidental deletions, or security breaches. Why nmrXiv? nmrXiv is the ﬁrst FAIR and Open archive to preserve NMR data in its original instrument format. It promotes Open Data and Open Standards to maximize the long-term sustainability of the resource and the FAIRness of the archived data. Over the past few decades, several repositories have been developed to host literature-derived and experimental NMR data; however, these repositories do not meet the needs of all chemical communities (also natural products & metabolomics) in several ways. This includes a lack of experimental data, limited search capabilities, and more importantly, they are not FAIR compliant. SmartLab Repos 4Chem Ontologies 4Chem Community 4Chem Legal 4Chem Standards 4Chem Editors 4Chem RAW FILES PROCESSED FILES ~ STANDARD FORMATS LONG TERM ARCHIVAL Version 3.0 Version 2.0 Version 1.0 WEB API AI/ML tools CASE SEARCH ENGINES STEP 1: FILE UPLOAD ARCHIVAL / PUBLISHING STEP 2: ASSIGNMENTS & META-DATA STEP 3: VALIDATION nmrXiv follows a documentation-ﬁrst approach that allows developers & users to discuss proposed features and ensure that the implementations reflect the real use cases. DOCS: https://docs.nmrxiv.org Advanced Spectra Analysis Demo https://dev.nmrxiv.org Code repository https://github.com/NFDI4Che m/nmrxiv Submission steps* STEP 1: FILE UPLOAD STEP 2: ASSIGNMENT & META-DATA STEP 3: VALIDATION Drag and drop your raw ﬁles and


COLOUR, LIPID AND PROTEIN OXIDATION IN BREAST AND THIGH MEAT OF BROILERS RAISED IN FOUR PRODUCTION SYSTEMS IN BELGIUM Zeshan Ali*, Eline Kowalski and Stefaan De Smet Laboratory for Animal Nutrition and Animal Product Quality, Department of Animal Sciences and Aquatic Ecology, Ghent University, Belgium *Corresponding author email: Zeshan.Ali@ugent.be I. INTRODUCTION Worldwide, broilers are raised in different production systems from extensive to intensive, covering a range of genetics and management practices. Influence of the production system on the oxidative stability of meat has not been widely studied [1]. Oxidation of myoglobin, lipids and protein are major causes of quality deterioration in meat [2]. Differences in in vivo and postmortem muscle metabolism may affect the endogenous antioxidant defense system and the release of pro-oxidants and reactive oxygen species, resulting in potential differences in resistance against oxidation. The main objective of the present study was to compare oxidation in breast and thigh meat from broilers produced in four divergent production systems in Belgium. II. MATERIALS AND METHODS In this study, 4 broiler production systems with distinctive characteristics (Intensive, Better Chicken Commitment (BCC), Slow growth with outdoor access and Organic) were selected (Table 1). From each production system, 5 farms randomly distributed in the country were chosen, and 15 broilers (mixed sex; 3 broilers per farm) were slaughtered and sampled. On day 2 after slaughter, the meat from the thigh and breast muscles (skinless) was minced and approximately 40 g was placed in petri dishes. These petri dishes were covered with a foil to limit dehydration and exposed to light (1600-2200 lux) for 7 days in the fridge at 2-4 °C. Colour lightness (L*), redness (a*), and yellowness (b*) were measured daily in duplicate with a Hunterlab Miniscan colour meter (D65 light source, 10° standard observer, 45°/0° geometry, 1-inch light surface, white standard) to estimate colour stability. The difference (day1 – day7) in colour lightness (ΔL), redness (Δa), yellowness (Δb) and total colour difference ΔE (ΔE = [(ΔL)2 + (Δa)2 + (Δb)2]1/2) was calculated for this purpose. On day 7, the samples were vacuum packed and frozen at -80°C for analysis of lipid and protein oxidation. Lipid oxidation was assessed in duplicate, spectrophotometrically by the thiobarbituric acid reactive substances (TBARS) method based on Tarladgis et al. [3] and expressed as malondialdehyde (MDA) in µg per g meat. Protein oxidation was measured in duplicate through the formation of protein carbonyls compounds (PCC), according to the method of Oliver et al. [4] with some modifications by Ganhao et al. [5]. PCC were determined spectrophotometrically, following their covalent reaction with 2,4- dinitrophenylhydrazine (2,4-DNPH), and expressed in nmol carbonyls per mg protein. Table 1 Summary of production characteristics This data was summarized from 18 farms sampled so far (Intensive, Slow growth and Organic n=5 each, and BCC n=3) *Outdoor access was temporarily not possible due to avian flu. Intensive BCC Slow growth Organic Breed Ross 308 RedBroM Ja 757 Ruby XL (SASSO) Age at slaughter (days) 39-42 42-45 56 73-76 Live weight at slaughter (kg) 2.6-2.8 2.4-2.6 2.1-2.3 2.3-2.5 Stocking density (kg/m2) 42 30 27-33 21 Outdoor access No No Yes (limited)* Yes*


Measuring coastal upwelling using IMOS Himawari-8 and Multi-Sensor SST Helen Beggs, Christopher Griffin, Gary Brassington and Pallavi Govekar Bureau of Meteorology, Melbourne, Victoria, Australia Contact: helen.beggs@bom.gov.au www.imos.org.au IMOS is a national collaborative research infrastructure, supported by Australian Government. It is led by University of Tasmania in partnership with the Australian marine and climate science community. 8. Acknowledgements We acknowledge the provision of raw AVHRR data from ground-stations operated by the Bureau of Meteorology, Australian Institute of Marine Science, Western Australian Satellite Technology Applications Consortium, Geosciences Australia and Commonwealth Scientific and Industrial Research Organisation (CSIRO).We also acknowledge the provision of NPP VIIRS SSTskin retrievals from the National Oceanic and Atmospheric Administration (NOAA) and the provision of the Himawari-8 AHI L1b data from the Japanese Meteorological Agency (JMA) and Japanese Space Agency (JAXA). 1. Introduction The Australian Bureau of Meteorology (BoM) have since 24th March 2016 produced operational, real-time, sea surface temperatures (SST) from the Himawari-8 geostationary satellite every 10 minutes at ~2 km spatial resolution (at nadir) on the native satellite ("GEO") projection. For ease of use, and to reduce spatial data gaps due to cloud, these native resolution SST data have been composited to hourly and daily night-only mean SST files, projected onto the rectangular Integrated Marine Observing System (IMOS) grid at 0.02o x 0.02o. The compositing of the Himawari-8 data on the IMOS grid presents opportunities for use alongside operational IMOS "Multi-Sensor" SST products incorporating data from the Visible Infrared Imaging Radiometer Suite (VIIRS) and Advanced Very High-Resolution Radiometer (AVHRR) satellite sensors, to identify coastal upwelling events. The aim of this study is to determine if these new IMOS satellite products can be used to verify the efficacy of the Bureau's operational version 3.1 Ocean Modelling, Analysis and Prediction System (OceanMAPS) 10 km resolution model (BoM, 2017) in resolving and predicting coastal upwelling around the Australian coast. To assist the study, we also compare with an experimental Ensemble Optimal Interpolation (EnOI) 10 km resolution SST analysis ("GSAS") of the same satellite SST data assimilated into OceanMAPS, using the same Sakov (2014) assimilation system. 4. Coastal upwelling case studies • Himawari-8 Level 2 Pre-processed (L2P) SSTskin is produced by training Himawari- 8 brightness temperatures to NOAA's ACSPO Suomi-NPP VIIRS L2P bias corrected SSTsubskin on a single day in 2015, followed by subtracting 0.17oC • Quality level (QL) is derived for each SST value based on proximity to cloud, identified using GEOCAT method (http://cimss.ssec.wisc.edu/csppgeo/geocat.html), and size of estimated error, estimated on "local brightness temperature variability” • Possible quality levels are 0 to 5, with 5 identifying highest quality • 10 minute Himawari-8 L2P SSTs are composited to hourly Level 3 Collated (L3C) SST by selecting best quality, spatially and temporally consistent value • Hourly SSTs are composited to daily, night-time L3C SST by selecting best quality value, closest in time to local sunrise • Hourly or daily L3C data on GEO projection are mapped to IMOS 0.02o x 0.02o grid using sub-pixel area-weighted averaging of any overlapping pixels (Fig 1a-b) • Night-time Himawari-8 L3C QL ≥ 4 SST from 1 Nov 2017 to 30 Apr 2019 over IMOS domain biased -0.4oC with 0.9oC standard deviation compared with collocated drifting and tropical moored buoys (BoM fv01 SST Validation Web Page) • Himawari-8 L3C netCDF files from 1st October 2017 to present available on request 5. Conclusions We compared night-time 2 km composites of Himawari-8 and Multi-Sensor (AVHRR and VIIRS) SST data at ~0.2 m depth with the BoM operational OceanMAPS v3.1 SST analyses and forecast


DATA ANALYSIS WITH TOPIC MODELS FOR COMMUNICATIONS RESEARCHERS FREDERICK BOEHM (FRED.BOEHM@WISC.EDU), DEPARTMENT OF STATISTICS, UNIVERSITY OF WISCONSIN-MADISON ABSTRACT We introduce topic modeling as a tool when analyzing textual data. We illustrate our methods with analyses of New York Times transcripts and tweets from three days in March 2016. We argue that such analyses will be useful in mass communications and journalism research. These methods are especially useful for identifying topics, or themes, in large collections of texts, when reading each piece individually is impractical. INTRODUCTION Social media users ﬂood us with tweets, status updates, and blog posts. Data analysis with topic models enable re- searchers to identify themes, or topics, in a collection of texts. We present results from separate analyses of 1) New York Times articles from March 19, 20, and 21, 2016 and 2) a collection of tweets (from Twitter) from the same three days. Our manuscript contains computing code to repro- duce our ﬁndings. REFERENCES [1] David M Blei. Build, compute, critique, repeat: Data analysis with latent variable models. Annual Review of Statistics and Its Applica- tion, 1:203–232, 2014. METHODS 1. Fit latent Dirichlet allocation (LDA) models, sepa- rately, to 1) our collection of tweets and 2) our collec- tion of print media articles from the New York Times 2. Visualized the topic modeling results with word clouds 3. Assessed resulting topics for coherence RESULTS video music march song tonight live justin check listen album fly show reaction love night pm ft day bieber watch playlist nowplaying fans radio star today added movie official priceless book la playing np soundcloud stage drake dj de years rihanna house tour young talks feat batman coming band list Figure 1: Word cloud for one topic (from a 20-topic model) of tweets from March 19, 20, and 21, 2016. game city win league season man team leicester today goal points fans united play good back football mufc rashford manchester time half top games state st great year goals player lead players chelsea point penalty west basketball years won marchmadness match derby day big iowa demichelis final premier home live Figure 2: Word cloud for one topic (from a 20-topic model) of tweets from March 19, 20, and 21, 2016. music show film theater production movie song songs musical work director played dance ballet company album play movies set performance life role stage york star country broadway story williams band opera character festival love series sound altman works record shows orchestra plays films center season drama bowie concert dancing singer Figure 3: Word cloud for one topic (from a 20-topic model) of New York Times articles from March 19, 20, and 21, 2016. water baalsrud island men ship arctic boat ships cruise islands expedition sea kelen miles ocean small feet river franklin genz inuit crew story found trip hawaii cruises north food wind norwegian di head escape baalsruds huth snow open pacific frozen joel haug local van coast william lake deck cabin canoe Figure 4: Word cloud for one topic (from a 20-topic model) of New York Times articles from March 19, 20, and 21, 2016. DISCUSSION From the word clouds above, and those not shown, we ﬁnd differences between the topics of discussion on Twitter and the topics in the New York Times. For instance, we ﬁnd in the tweets an entire topic that deals with sports (with an emphasis on soccer) and another topic that involves music and entertainment. The New York Times analysis yields topics that match many of the newspaper sections. The two topics above might be called "Music" and "Travel & Adventure".


The BDF format was created based on EDF, but BDF supports 24-bit resolution. In this sense, if there is a need to convert a BDF file to a more widely used format such as the EDF, there may be loss of information. The GDF format allows several other formats to be converted to it without loss [7]. EDF yielded the best compression capability, and the GDF occupies the largest disk space. The XML-based formats (ecgML, HL7, OpenXDF) follow a pattern in which there is a hierarchical structure with attributes addressing the characteristics and configurations of the file, unlike the others, whose information is based on a sequence of data controlled by the positioning of the characters. It would be interesting to have a tool capable of providing information to manufacturers, developers, researchers of these formats, to keep their information and the characteristics updated, helping thus, future researches, problem corrections and better implementations. ACKNOWLEDGEMENTS REFERENCES DISCUSSION AND CONCLUSION 1Aluno pós-graduação, Faculdade de Engenharia Elétrica, Universidade Federal de Uberlândia - jpfolador@gmail.com INTRODUCTION The primary purpose of biomedical data acquisition is monitoring, diagnosis or research, and its recording depends on these goals [1]. Thus, monitoring of vital signs in a surgery requires immediate analysis and visualization, whereas data collection for research or diagnosis needs to store the data in the first place, dispensing real- time visualization [2]. These biomedical signals can be continuously measured in different ways depending on the underlying physiological phenomenon responsible for its generation. In any approach related to biomedical signal collection it is necessary to verify memory occupancy and the quality of stored information for avoiding data loss [1][2] A large amount of biomedical data is generated by the recording of time varying signals from different parts of the body, for instance, the electroencephalogram (EEG), electrocardiogram (ECG), electromyogram (EMG), electrooculogram (EOG) and inertial activity. In this context, over the years the medical industry and research consortiums have been addressing the issue of establishing the most suitable data format for the storage of biomedical time-series [3]. The search for standardization and its adoption can reduce costs, optimize joint work, and increase the quality of research results [4]. The first objective of this work was to identify the most used types of file formats employed for storage of time-series resulting from biomedical data. The second purpose was to compare distinct file formats by verifying data compression rates and suitability. MATERIALS AND METHODS In order to understand the file formats used in the recording of biomedical signals and their context today, some questions were raised: • What are the file formats used to collect biomedical signals? • What are the features and information available in these formats? • Is there a file format that is widely used and supports different biomedical signals? • Do commonly used files take up a lot of storage space? [1] Bronzino J. D. Medical Devices and Systems: The Biomedical Engineering Handbook, 3rd ed. CRC Press, Hartford, Connecticut, U.S.A (2006). [2] Penzel, T., Acquisition of biomedical signals databases. IEEE Eng Med Biol Mag 20:25–32. (2001). [3] Rubel, P., SCP: ECG V3.0: An enhanced Standard Communication Protocol for computer:assisted Electrocardiography. In: Computing in Cardiology Conference (CinC), 1–4 (2016). [4] Värri, A., Kemp, B., Penzel, T., Schlögl, A. Standards for biomedical signal databases. IEEE Eng Med Biol Mag 20:33–37 (2001). [5] Institute of Science and Technology: Scientific data formats. http://pub.ist.ac.at/~schloegl/matla b/eeg/. last accessed 2018/01/30. [6] Kemp, B., Olivan, J. European data format “plus” (EDF+), an EDF alike standard format for the exchange of physiological data. Clin Neurophysiol 114:1755–1761. (2003). [7] Schlögl, A. GDF


SPECTROSCOPIC ANALYSIS OF OB STARS IN THE CARINA NEBULA Simone Daﬂon 1, Wilton Santos 1,2, João Victor Sales Silva 1, and the Gaia-ESO Survey Team 1Observatório Nacional 2UESC Introduction Massive OB stars are luminous and young objects, being easily observed and located close to their place of birth, allowing the mapping of the present-day abundances of the Galaxy. OB stars are generally found in OB associations, one of them is Car OB, a large, very active star-forming region in the Carina- Sagittarius spiral arm. Its stellar population is split into several open clusters associated with the Carina Nebula. In this work, we present a detailed spectroscopic study for a sample of OB stars located in 8 open clusters in the Carina Nebula: Trumpler 14, Trumpler 15, Trumpler 16E/W, Collinder 228, Collinder 232, Bochum 11 and NGC 3293. Data This study is based on high-resolution spectra obtained with the FLAMES/GIRAFFE spectrograph coupled to the UT2 VLT 8 m telescope, in the context of the Gaia-ESO Public Spectroscopic Survey. The GIRAFFE conﬁgurations are optimized to detect important features in the spectra of early-type stars such as Hγ line, an important log g-indicator and some important lines for Teff diagnosis, as for example, C iii, O ii, Si iii, and Si iv lines. Projected rotational velocity We obtained the projected rotation velocity V sin i for a sample of 330 OB stars, probable members of 8 open clusters in the Carina Nebula, based on a calibration for the widths of two He i lines, at λ 4388 and 4471Å[2]. The V sin i distribution for the full sample represented by the blue histogram (Fig 1) is consistent with typical V sin i distributions for open clusters while the V sin i distributions for ﬁeld OB stars tend to peak at lower V sin i. Fig 2 presents the violin distributions for the 5 clusters of our sample with more than 40 studied stars: the average V sin i for individual clusters varies between 126±77 km s−1, for Collinder 228, and 180±84 km s−1, for NGC 3293. Stellar Parameters and Abundances We use a semi-automatic routine based on non-NLTE model atmospheres and synthetic spectra (TLUSTY/SYNPLOT) [1, 3] to perform a self-consistent analysis and determine the atmospheric parameters Teff, log g, V sin i, microturbulence and macroturbulence, as well as abundances of Silicon, Oxygen, Carbon and Nitrogen, for a subsample of 65 sharp-lined stars. The eﬀective temperature has been deﬁned from the ionization balance between Si ii, Si iii, and Si iv (Fig 3), while log g has been derived from the ﬁts of H wings (Fig 4). Results The stars in our sample are mainly on the main sequence, with Teff between 14,000 and 33,000 K and log g between 3.00 and 4.50 (Fig 5). In Fig 6 we present the violin distributions for the abundances of studied species. The average abundances of C, N, and O are consistent with the solar value while being slightly subsolar for Si. Our results suggest that the Carina Nebula is chemically homogeneous to within ∼ 0.10 dex and the average abundances of O and Si are consistent with its radial position in the Galactic disk (Fig 7), as expected by [1]. References [1]G. A. Bragança, S. Daﬂon, and et al. A&A, 625:A120, 2019. [2]S. Daﬂon, K. Cunha, F. X. de Araújo, S. Wolﬀ, and N. Przybilla. The Astronomical Journal, 134:1570–1578, 2007. [3]I. Hubeny and T. Lanz. arXiv:1706.01859, 2017. Acknowledgements W.S acknowledges ﬁnancial support from CAPES and FAPERJ for Ph.D. fellowships. S.D. acknowledges CNPq/MCTI for grant 306859/2022-0.