M. Ponzelli1, R. Moreno1, I. Etxeberria2, A. Artola2, A. Barrio2, N. Mattar3, W. Pitacco4, L. Staccioli5, O. Reyes5, J. Gallego5, C. Pagella6, I. Deligkiozi1 This project has received funding from the Bio-based Industries Joint Undertaking (JU) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101023342. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the Bio-based Industries Consortium. BIO-BASED SUSTAINABLE COATINGS WITH LIGNIN RESINS FOR ENHANCED PERFORMANCE AND ENVIRONMENTAL IMPACT 1 AXIA Innovation GmbH, Fritz-Hommel-Weg 4, 80805, Munich, Germany 2 TECNALIA, Mikeletegi Pasealekua 2 Parque Científico y Tecnológico de Gipuzkoa, 20009 Donostia-San Sebastian, Gipuzkoa, Spain 3 ECOAT, ZI Des Bois De Grasse, 1 avenue Louison Bobet, 06130, Grasse, France 4 AEP Polymers SRL, AREA Science Park, Strada Statale 14, km 163.5, 34149 Basovizza, Trieste, Italy 5 ARDITEC Association, 7 Av. De Fabron, 06200, Nice, France 6 IRIS Coatings SRL, Via Novi 42, 15060, Basaluzzo (AL), Italy @LIGNICOAT BBI Project @LIGNICOAT BBI Project www.lignicoat.eu info@lignicoat.eu Sustainable coatings based on lignin resins and bio-additives with improved fire, corrosion and biological resistance Materials and Methods Introduction and Background Coatings play a crucial role in our daily existence by offering protection, enhancing aesthetics, and providing functionality to different surfaces. Nevertheless, the environmental repercussions associated with coatings derived nowadays from fossil fuels and the emission of volatile organic compounds (VOCs) have prompted concerns. Towards the road of defossilization and the creation of a sustainable bioeconomy, the LIGNICOAT project is developing innovative lignin-based resins and coatings. Lignin, a by-product of lignocellulosic biomass, is a natural polymer that can be used as a building block for producing biobased resins. LIGNICOAT particularly targets biobased coating with enhanced properties in terms of fire, corrosion, and antimicrobial resistance. 1 Materials: The development of biocoatings includes: • Bio-PUD resins, synthesized from lignin polyols *. • Phosphorous-based flame-retardant additives. FR water-borne biocoatings are applied on wood substrates as an FR alternative to market solvent-borne coating (CHAR18, IRIS Coatings). Methods: • Hardness by Persoz Pendulum. • Transparency and colour by colorimetry. • Fire performance evaluation by cone calorimeter on particleboard (PB) at a heat flux of 35 kW/m2. INTERMEDIATES LIGNIN RESINS COATINGS • Kraft Lignin • Organosolv Lignin Fire protection Anti-corrosion Anti-microbial, anti-viral & VOCs degradation • Lignin Polyols • Lignin Polyacids • Epoxidized Lignin • Polyurethane • Alkyd • Epoxy • Wood • Metal • Bio-PUD coatings without any FR additives (Bio_1 and Bio_2) showed even worse fire resistance behaviour than the PB without coating. • FR additives (P or Cl) significantly improved the fire performance of Bio-PUD coatings (Bio+FR_1, Bio+FR_2, and Bio+FR_3). • The developed FR water-borne biocoatings have similar fire performance to the market benchmark in terms of heat release. • The biocoating Bio+FR_3 could be a suitable candidate for replacing fossil-based ones as a 26%, and 38% improvement of the maximum average rate of heat emission (MARHE) was noticed compared to the market reference and the PB with no coating, respectively. Coating Composition NCO % Bio- based tIGNITION (s) HRR Peak (kW/m2) MARHE (kW/m2) TSP (m2) Persoz Hardness (s) Colour dE*ab (D65) No coating - - - 67 208 89 2.3 - - Market Solvent-borne PU 2K (10% Cl) HNCO 0% 67 176 75 3.5 115 2.4 Bio_1 Bio_PUD - 46% 43 197 95 3.4 55 17.4 Bio_2 Bio_PUD HNCO 42% 45 214 94 2.5 62 17.2 Bio+FR_1 Bio_PUD + 15%P + 3%Cl HNCO 47% 35 179 67 2.4 29 12.6 Bio+FR_2 Bio_PUD + 15%P + 3%Cl Bio- HNCO 50% 38 186 73 2.9 19 17.8 Bio+FR_3 Bio_PUD + 20%P + 1%Cl HNCO 47% 41 137 55 2.3 26 16.5 0,00 1,00 2,00 3,00 4,00


RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com Electronic Health Records (EHR) provide a rich source of population data that can be used to systematically understand multimorbidity. Robust measures of association are hypothesis-generating if their co-occurrence is higher than expected. However, prevalent methodological framework are unstable when evidence is limited. Associations between conditions canbe assembled into a network of multimorbidity, where network analysis can be used to understand the role of diseases, ﬁnd clusters, or study disease progression. The effects of unreliable association measures get aggregated and intensified when performing network analysis. These problems affect particularly to minorities (small but important subgroups), for which there is less data available. We have developed a Bayesian inference framework that is robust to sparse data in the analysis of multimorbidity patterns. The framework also has the following benefits: - Explicit estimation of uncertainty - Robust to decisions in the methodology - Robust to noise in rare conditions Background and motivation Methods Retrospective cross-sectional study of a representative dataset of primary care patients in Scotland as of March 2007. We included 40 long-term conditions and studied their associations in 12,009 individuals aged 90 and older, stratiﬁed by sex (3039 men, 8970 women) We analysed associations obtained with Relative Risk (RR), a standard measure in the literature, and compared them with our proposed measure, Associations Beyond Chance (ABC). To enable a broad exploration of interactions between long-term conditions, we built networks of association and assessed differences in their analysis when associations are estimated by RR or ABC. Results Our Bayesian framework was appropriately more cautious in attributing association when evidence is lacking, particularly in uncommon conditions. This caution in reporting association was also present in reporting differences in associations between sex and affected the aggregated measures of multimorbidity and network representations. Incorporating uncertainty into multimorbidity research is crucial to avoid misleading ﬁndings when evidence is limited, a problem that particularly affects small but important subgroups. Our proposed framework improves the reliability of estimations of associations and, more in general, of research into disease mechanisms and multimorbidity. Multimorbidity analysis with low condition counts: A robust Bayesian approach for small but important subgroups Guillermo Romero Moreno, Valerio Restocchi, Jacques Fleuriot, Atul Anand, Steward Mercer, Bruce Guthrie Conclusion Reference Romero Moreno G., Restocchi V., Fleuriot J., Anand A., Mercer S., Guthrie B., “Multimorbidity analysis with low condition counts: A robust Bayesian approach for small but important subgroups”, eBioMedicine, Volume 102, 2024, 105081, https://www.sciencedirect.com/science/article/pii/S2352396424001166 This study/project is funded by the NIHR under the AI for Multiple Long-Term Conditions (AIM) programme, NIHR202639. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Model This model of multimorbidity generation assumes: i) hypothetical risk factors affecting the appearance of each LTC independent of the others, ii) hypothetical common mechanisms that simultaneously affect a pair of LTCs and lead to their co-appearance, e.g. common risk factors or one LTC increasing the risk of acquiring the other. ABC reflects the ratio of generation by common mechanisms as compared to independent factors: ABC = 1 + fij / fi fj These are then embedded in a fully Bayesian framework: Priors Code The code for implementing our framework is publicly available at https://github.com/Juillermo/ABC. It has also be published as an easily installable python package, via pip install abc-network ( https://pypi.org/pro


TITULO CONDRODISPLASIA PUNTEADA DE TIPO DOMINANTE, LIGADA AL CROMOSOMA X. (SINDROME DE CONRADI-HUNERMANN). CASO CLINICO Autores: Dra. Idarmis Jiménez, genética clínica; Dra. Nelly Báez, neonatóloga; Dra. Susy Ampudia, pediatra; Dra. Audrey García, pediatra; Dr. Alejandro Montes, médico ocupacional. INTRODUCCIÓN El síndrome de condrodisplasia punteada descrito por Conradi y por Hunerman, se caracteriza por deficiencia del crecimiento entre leve y moderada, dismorfias faciales como puente nasal deprimido, cara plana, hipoplasia de las eminencias malares con fisuras palpebrales descendentes. Orejas displásicas, alteraciones oculares como nistagmos y catarata. Presenta además calcificaciones traqueales con estenosis asociada de la tráquea, acortamiento asimétrico relacionado con áreas de mineralización punteada en las epífisis, contracturas articulares variables, escoliosis relacionada con áreas de mineralización punteada y calcificaciones paraespinales. En piel puede encontrarse escamas adherentes gruesas, atrofodermia folicular variable, con poros grandes, ictiosis y alopecia. Luxación de rotula y defectos cardiacos. CASO CLÍNICO Recién nacido por cesárea producto de 4ta gestas, le anteceden 3 abortos espontáneos, madre de 31 años con antecedentes prenatales por ecografía de ausencia de hueso nasal y huesos largos cortos, por lo que se realiza estudio citogenético molecular mediante sonda FISH en líquido amniótico y no se encontró alteración numéricas de los cromosomas estudiados 13, 18, 21, X, Y. Nace con un peso de 2914 g y talla 36,5 cm, leve acortamiento risomélico de huesos largos, cuello corto y tórax corto con teletelia. Facies grotesca, puente nasal muy plano, hipoplasia del tercio medio de la cara, nariz pequeña, macroglosia y dificultad respiratoria, por lo que necesitó oxígeno hasta los 2 meses de vida. Pie con camptodactilia del 4to dedo e hipoplasia ungueal, además de soplo cardiaco sistólico grado II/VI. BIBLIOGRAFÍAS 1-SMITH. Patrones Reconocibles de Malformaciones Humanas, ElSEVIER España; 2007; 6e ed. en español. 2-CRUZ HERNANDEZ/ BOSCH HUGAS, Atlas de Síndromes Pediátricos. ESPAXS, España; 1998; 01 ed. DISCUSIÓN La Condrodisplasia Punteada puede encontrarse en un sinnúmero de diferentes enfermedades genéticas. Puede ser adquirida intrautero por exposición de la madre o con patrón de herencia autosómica dominante, autosómica recesiva, ligada al sexo recesiva y dominante. La mineralización punteada temprana y poros cutáneos grandes durante la primera infancia, producen un fallo de medro e infecciones. Regularmente es letal en el hombre y muchos fallecen en etapa neonatal, si el paciente sobrevive durante los primeros meses, el pronóstico es bueno. El punteado de las epífisis de los huesos largos se suele resolver hacia los 9 meses, son frecuentes los problemas ortopédicos y hay riesgo alto de cataratas. Existen unas 15 mutaciones de un gen ligado al cromosoma X como deleciones, translocaciones y puntuales localizados en (Xp22.3). El diagnóstico más probable de nuestro paciente es el síndrome de Conradi-Hunerman y se realizó por la clínica, estudio de imágenes y antecedentes maternos de 3 abortos con diferente pareja pudiera sugerirlo también. En Rx de cráneo y cara huesos propios de la nariz: protuberancia frontal, ausencia de hueso nasal. Rx de tórax: se observa calcificaciones punteadas a nivel de los cartílagos en toda la columna dorso-lumbar y calcificaciones punteadas en articulación acromio-clavicular y glenohumeral. Ecocardiograma: PCA, CIA tipo os. CONCLUSIONES El estudio molecular es el diagnóstico definitivo de las enfermedades genéticas de origen génico. Debido a la heterogeneidad genética del síndrome, la orientación genética debe ser el pilar de prevención de este síndrome. El tratamiento es sintomático y aun no existe uno específico. PRIMERA JORNADA MÉDICA ACADÉMICA DE BIENESTAR MATERNO-NEONATAL Y GINECOLÓGICO “HGOIA”


Re-Executability Assessment of the Recent Autism Literature David Kennedy, Christian Haselgrove, Steve Hodge, Leah Honor, Jean Frazier University of Massachusetts Medical School, Worcester, MA, USA Introduction: There is concern about the stats of reproducibility in science in general and neuroimaging neuroscience in particular (Gorgolewski and Poldrack 2016; Button et al. 2013). A particularly germain concern was expressed by Insel and colleagues in lamenting: “a profusion of statistically significant, but minimally differentiating, biological findings; ‘approximate replications’ of these findings in a way that neither confirms nor refutes them” (Kapur, Phillips, and Insel 2012). The replication of a specific finding (or reproducibility of a specific analysis), as reflected in a publication, has many details and nuances to it (Kennedy et al. 2019). Often, we are searching for the ‘generalizability’ of a finding: does the finding hold true when using ‘similar’ data and a ‘similar’ analysis. In this poster, we: 1) develop a specification for what constitutes an assessment of the re-executability for a given publication, in each of the domains of: data, software, execution environment, statistics and results; 2) codify this assessment in survey form; and 3) apply the survey to a subset of the autism neuroimaging literature published recently (~2018). From the results of this survey, we can begin to generalize the state of the re-executability of the recent autism neuroimaging literature, in order to identify trends and opportunities for the enhancement of the re-executability status in support of greater overall generalizability (and hence reproducibility) of the literature. Methods Survey Development: In order to assess the prospects of re-execution of a given paper, we assess 1) the availability of the starting data, 2) the precision of the analysis description (both data processing and statistical assessment), and 3) the availability of the detailed complete results (in order to verify accuracy of re-execution). Regarding the ‘availability of the starting data’, we assess if the publication indicates how someone (other than the authors themselves) could appropriately access the data. The ‘precision of the analysis description’ ultimately asks if a reader who is reasonably skilled in the necessary domains, could precisely carry out the prescribed analysis steps. Specifically, are the software versions, operating system and complete parameters somehow made available to the reader? The ‘detailed complete results’ assesses if the publication indicates how to obtain the complete results, in order to both verify that the re-execution generates the same result and to overcome the limitations of selected summary only being presented, which impedes a more complete meta analysis of the literature. Literature Identification: On January 23, 2019, the following pubmed query was executed: (("autistic disorder"[MeSH Terms] OR ("autistic"[All Fields] AND "disorder"[All Fields]) OR "autistic disorder"[All Fields] OR "autism"[All Fields]) AND ("magnetic resonance imaging"[MeSH Terms] OR ("magnetic"[All Fields] AND "resonance"[All Fields] AND "imaging"[All Fields]) OR "magnetic resonance imaging"[All Fields] OR "mri"[All Fields])) AND ("2014/01/25"[PDat] : "2019/01/23"[PDat] AND "humans"[MeSH Terms]) This is the expansion of the general query for ‘autism AND MRI, qualified to select publications between 1/25/2014 - 1/23/2019 and where the MeSH term includes ‘human’. This query generated 811 resultant publications at the time of the query. Figure 1: Overview of the survey design. Data Availability: Sixteen of the 50 (32%) publications make reference to the availability of the data used in the publication. However, publications that indicate availability are reusing data from the large repositories, whereas the publications that do not indicate data availability are principally locally conducted studies. Thus, this indicates that a large fraction


Model Annotation The figure below presents some of the information with which we have enriched a cohort of kidney models meta-data in the form of semantic annotations available in the Physiome Model Repository (PMR). In particular, we extracted each of the mathematical variables from the models and associated them with a biologically meaningful knowledge. Model Discovery Utilizing these biological annotations, we are able to frame queries to PMR using biologically relevant terms. Our prototype web interface presents the search results obtained from querying the PMR services with the biological context; including models of similar biology and a recommender system. Background Model Composition Once a user is satisfied with the model built and graphically edited using our platform, they will then be able to generate a novel model meeting their requirements. Utilizing the modularity and reuse capabilities of CellML, we are able to create a new CellML model by directly reusing and customizing the existing models discovered by the user. Model Verification For testing purpose, we have begun implementing a verification system which allows users to discover simulation experiments which match the features of the novel models users create. By executing these simulation experiments with the novel models and comparing to previous model predictions and/or experimental or clinical observations we are able to provide the user with some measure of verification that their model matches, or doesn’t match, existing knowledge captured in the various repositories utilized. Epithelial Modelling Platform: A Tool for Investigating Hypotheses through Discovery and Assembly of Computational Models of Epithelial Transport Dewan M Sarwar (dsar941@aucklanduni.ac.nz), Koray Atalag, Peter J Hunter, David P Nickerson (d.nickerson@auckland.ac.nz) Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand Acknowledgements This poster at Scientists often leverage computational models of biological systems to investigate hypotheses which are difficult or prohibitively expensive to achieve experimentally. Such investigations are best achieved by utilizing suitable computational models, reusing existing validated models where possible and creating novel models consistently as needed. This requires tools which enable the discovery and exploration of existing models matched with assistance in constructing and testing new models. Enabling biomedical engineers to use such a tool by allowing them to describe their requirements in a manner familiar to them greatly improves the utility of the tool. This tool is not quite ready for pure biologists or clinicians to use. We have developed a web-based tool, the Epithelial Modelling Platform, for discovery of relevant models and assemble them into a novel model customized for investigating their hypotheses. While our tool specifically focuses on epithelial transport, by utilizing relevant community standards and publicly accessible knowledge repositories, it is extensible to other areas of application. The platform abstracts underlying mathematics of the computational models and provides a visual environment which mimics biophysical phenomena of an epithelial cell. Presented below is an overview of our knowledge management platform being developed and utilized in this work. Modeling Platform Presented on the top-right column is the web-based epithelial modelling platform to discover, explore and assemble models where users would be able to create and verify new epithelial models. This platform allows users to drag and drop models between apical and basolateral membranes. Solutes, e.g. sodium, potassium, will be floating in specific compartments. Modelers and clinicians can use this platform to build models to help investigate specific research questions and hypotheses. https://github.com/dewancse/model-discovery-tool https://github.com/dewancse/epithelial-modelling-platform


Benchmarking New Hardware for Machine Learning for Particle Physics Cavendish Laboratory, Department of High Energy Physics, University of Cambridge Stefano Vergani 4. Specs of Different PUs For this study, three different types of PUs will be used. They have different specifics, prices, and energy consumption and all of them must be taken into account when choosing the right one. 1. LArTPC Detectors • Liquid argon time projection chamber (LArTPC) detectors measure ionisation tracks produced by charged particles inside a cryostat filled with liquid argon. • The ionisation electrons drift in an electric field towards wire planes, where their charge is collected and measured. • For this work, a fictitious LArTPC detector has been simulated with GEANT4. 5. Neural Networks 2. Processing Units A Processing Unit (PU) is a circuit which performs operations. There are several of them: • Central Processing Unit (CPU): processes the basic instructions that drive a computer • Graphics Processing Unit (GPU): used in graphic rendering software and in video games. In recent years, it has been used also to perform matrix calculations for Deep Learning (DL) • Neural Processing Unit (NPU): a special groups of PUs designed specifically to perform matrix calculations for DL References: • [1] MicroBooNE Collaboration, JINST 12, P02017 (2017), ArXiv: 1612.05824v2 • [2] https://coral.withgoogle.com/products/accelerator Notes: *There is currently a known issue in the quantization of TF Lite models meaning that the accuracy of inference on the Edge TPU is not representative, and is hence not given here at this stage. The accuracy is expected to be identical between the CPU, GPU (as demonstrated) and Edge TPU, and this will be verified in the near future Only a certain subset of possible Neural Networks (NNs) can run on an Edge TPU. Among them, Residual Network 50 (ResNet-50) V2 and DenseNet-169 have been identified as the most promising. They have been trained with 10k images equally divided between neutrino Neutral Current (NC), νμ Charged Current (numu CC), and ν𝒆Charged Current (nue CC) events. Validation has been done with another set of 2k images equally divided between NC, numu CC, and nue CC events. Training and validation have been done using the popular TensorFlow software. 3. Tensor Processing Unit Tensor Processing Units (TPUs) are a subset of NPUs designed by Google to do tensor calculations. Edge TPU has portable sizes (65 mm x 30 mm). They have a very low power consumption and come at a cheap price (~80 USD). Figure 2: Picture of an Edge TPU compared to the size of a clip. Taken from [2]. 6. TensorFlow Lite 7. Results and Future Work The TensorFlow (TF) trained models have been subsequently converted to all the available TF Lite optimizations to test their speed and accuracy on CPU, GPU, and Edge TPU. The idea behind TF Lite is to make a lighter and faster model using quantization, that is converting weights and/or activations into 8 bits or float 16. This could lead to some accuracy loss. Edge TPU works only with quantized models. Table 2 presents a comparison between different versions of TensorFlow Lite. Table 2: Comparison between features of different TF Lite Optimizations. • TensorFlow Lite appears to be particularly useful for users with limited RAM on the CPU/GPU. • Edge TPU could be an interesting solution for users who cannot afford a GPU. Research centers could equip each workstation with one. Interesting for future R&D in edge computing for particle physics. • Future plans comprehend testing more NNs and a publication. Figure 1: On the left, sketch of a LArTPC taken from [1]. On the right, ionisation 𝑒− collected in the three different wire planes, from a fictitious LArTPC simulation. Processor Type CPU GPU EDGE TPU Model Intel ® Core ™ i7- 8550U @ 1.8 GHz NVIDIA Tesla P100 16 GB Coral Edge TPU TDP* (in w) 15 250 2 Commercial Price 99 USD 7500 USD 80 USD Table 1: Specifics of all the PUs used for this study. * Thermal Design


2763/ P229. Quantifying the DARTable Genome for Prediction of Teratogenic Doses - a case study using retinoic acid pathway-induced developmental toxicity R. A. Currie1, N. Principato2, T. B. Knudsen3, A. R. Kaczor4, L. Yu5, A. Letamendia6, A. H. Piersma7, and S. Mitchell-Ryan8. 1 Syngenta International Research Centre, United Kingdom; 2 Syngenta Crop Protection, Greensboro, NC; 3 EPA, Research Triangle Park, NC; 4 Merck & Co., Inc., West Point, PA, USA; 5 NCTR, FDA, Jefferson, AR; 6 Bayer Crop Science, Sophia Antipolis, France; 7 RIVM, Bilthoven, Netherlands; and 8 HESI, Washington, DC. In vitro assay potency: databases, patents, regulatory documents Pharmacokinetic data at N/LOEL: literature, TK elements of toxicity reports, regulatory documents In vivo toxicity: toxicology study reports, literature, regulatory documents Calculate Threshold Ratio using potency, PK and toxicity data This poster does not reflect EPA or FDA policy. • The goal of the HESI DARTable Genome Working Group is to build a compendium of quantitative molecular initiating events (MIEs) and key event biomarkers for teratogenicity prediction. • Our initial case study focused on an AOP framework linking adverse developmental outcome(s) to perturbation of each of the three retinoic acid receptor isotypes: alpha (RARa) , beta (RARb) and gamma (RARg). • This investigation focused on the relationship(s) between chemical potency on RAR targets and the quantitative threshold of maternal systemic exposure necessary to produce a teratogenic outcome. 2. Building a quantitative model for the DARTable genome: all-trans retinoic acid (ATRA) signaling. 1. Introduction This model can be used to calculate a Threshold Ratio of exposure below (or above) which the likelihood of a chemical causing a toxicity by that AOP is low (or high). 3. Reference Compounds. • For 20 compounds with known retinoid agonist or antagonist activity we compiled RAR potency for each RAR-isotype, including pharmacokinetic and toxicology information for rat and rabbits. • Here, we present results for 3 retinoids that had complete data in the rat, and 2 of which also had suitable rabbit data. 4. Results of Threshold Ratio visualization on 3 retinoid case examples. • We calculated Threshold Ratios for each RAR isotype utilizing the estimated dam or doe steady- state blood concentration at the NOEL and LOEL. • Model returns a Threshold Ratio for exposure- biological potency driving developmental toxicity at each RAR isotype. • An exposure-potency threshold > 2 for RARa or RARg best characterized LOELs for retinoid developmental toxicity; RARb did not fit the pattern. 5. Conclusions, lessons learned and next steps • The model derived DART-predictive exposure-potency Threshold Ratios to predict developmental toxicity; PK data was the largest missing data type. • Toxic responses considered as thresholds were driven by RARa or RARg from public data sources; however, RARb did not fit the pattern. • Relevant data overall can be unstructured or incomplete and difficult to find, access, or compile into a computable model. • ‘FAIR’ data principles are vital to enable sharing of the toxicity, potency and pharmacokinetic data for predictive toxicology. • It will be informative to determine if patterns for retinoid-based RAR target ratios generalize to chemicals that alter ATRA metabolism. • The next case study selected for the DARTable genome will focus on Thalidomide-like compounds. NOEL LOEL NOEL LOEL RARa 1.3 2.9 nd 1.91 RARb 0.10 0.22 nd 0.14 RARg 0.29 0.65 nd 0.43 RARa 0.01 0.03 0.002 0.02 RARb 0.04 0.12 0.008 0.06 RARg 0.69 2.1 0.126 1.04 RARa 0.65 13 nd nd RARb 2.8 57 nd nd RARg 0.65 13 nd nd Rabbit ratio compound receptor alitretinoin tazarotene trifarotene Rat ratio


These were drawn from theories of Visual Cognition and from requirements gathered from our experimental trials. ROBOTS WITH COMMON SENSE Improving Sensemaking in Service Robotics NAIVE PHYSICS LEARNING MODEL BUILDING FAST PERCEPTION We derived a set of "ingredients", i.e., required knowledge capabilities, for robots to exhibit human-like performance on sensemaking tasks. We identified the types of common sense knowledge which enable these capabilities. Hypothesis: the integration of common sense knowledge and knowledge-based reasoning with Machine Learning improves a robot's sensemaking capabilities. COMPOSITIONALITY INGREDIENTS OF VISUAL INTELLIGENCE Infants can already grasp basic principles of Physics before 6 months of age. Hence, large amounts of background knowledge are needed to help a robot to correctly interpret the observed scenario. The shiny object is NEXT TO a keyboard GENERIC 2D VIEWS MOTION VISION MACHINE READING Service robots assist humans by performing tasks in a variety of scenarios, including shops, restaurants, healthcare, delivering parcels, accessing hazardous environments, and others. PhD Student: Agnese Chiatti Supervisors: Enrico Motta Enrico Daga Our visual perception is extremely fast and we can learn to recognize new objects even from our very first exposure to them. The ability to read text from images is essential to recognize labelled items and signs. We categorise objects and actions differently based on the perceived movement (or lack thereof). FOCUS ON VISUAL INTELLIGENCE RESEARCH PROBLEM PROPOSED APPROACH The images cast at the back of our eye are 2-dimensional. We construct the 3D mentally. MEET HANS! Web: https://robots.kmi.open.ac.uk Methods based on Machine Learning have shown promising results. Nonetheless, machine Visual Intelligence is still inferior to human Visual Intelligence in many ways. The human eye identifies the different objects parts and the different nearby objects separately. Our hypothesis is being tested in the case of HanS, the Health & Safety robot inspector currently under development at KMi. Service robots need to make sense of complex and fast-evolving environments. They do so by using their perceptual sensors (e.g., vision, depth, touch) to identify the objects around them. However, different objects can look very similar to a robot (e.g., in certain light conditions the shiny surface of a radiator may look like a screen to a robot) It is a monitor, not a radiator. Our work focuses on the robot’s capability to use its vision system, reasoning components and background knowledge to make sense of its environment. Photo credits: Enrico Motta, Agnese Chiatti


References Funder, D. C., & West, S. G. (1993). Consensus, self-other agreement, and accuracy in personality judgment: An introduction. Journal of Personality, 61(4), 457-476. Retrieved from http://ezproxy.middlebury.edu/login?url=http://search.proquest.com/d ocview/618476264?accountid=12447 Lindová, J., Hrušková, M., Pivoňková, V., Kuběna, A., & Flegr, J. (2008). Digit ratio (2D:4D) and cattell's personality traits. European Journal of Personality, 22(4), 347-356. doi: http://dx.doi.org/10.1002/per.664 Lutchmaya, S., Baron-Cohen, S., Raggatt, P., Knickmeyer, R., & Manning, J. T. (2004). 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Human Development, 77(1-2), 23-28. doi: http://dx.doi.org/10.1016/j.earlhumdev.2003.12.002 Sellers, J. G., Mehl, M. R., & Josephs, R. A. (2007). Hormones and personality: Testosterone as a marker of individual differences. Journal of Research in Personality, 41(1), 126-138. doi: http://dx.doi.org/10.1016/j.jrp.2006.02.004 http://www.handresearch.com/news/five-fingers-relate-to-evolution- sports-behavior-disease-sex.htm http://www.epa.govt.nz:80/about-us/have-your-say/Pages/default.aspx Prenatal Testosterone and Self-Report Predicts Others’ Perceptions of Leadership Behaviors Kristina Conroy, Scarlett Kirk, Madeline Brooks, and Jennifer Guinn Sellers Abstract INTRODUCTION: Past research has demonstrated a relationship between the 2D: 4D ratio and prenatal testosterone exposure. (Lutchmaya et al., 2004) The 2D:4D ratio is calculated by dividing the length of the pointer finger (2D) by the length of the ring finger (4D) of the right hand. Individuals with a lower 2D: 4D ratio are thought to have experienced higher testosterone in utero. Relatedly, circulating testosterone has been found to influence certain personality characteristics such as dominance. The present study investigated the relationship between the 2D:4D ratio and leadership as a personality variable while looking at self report and informant reports of leadership. METHOD: 141 female undergraduate students at Middlebury College were recruited. Participants were asked to complete the experiment with a close friend or teammate. They were asked to have their right hand scanned, to answer a series of questions about their own leadership tendencies, and to answer a series of questions about the person with whom they completed the experiment. RESULTS: A 2x2 ANOVA revealed that finger length and self-report of leadership independently indicated informant report of leadership. Participants with a lower ratio who reported themselves as high on leadership scored the highest on informant leadership. DISCUSSION: Our findings indicate that testosterone exposure lies outside the individual’s awareness, but is perceived by close friends and acquaintances. This research shows the potential of testosterone and the 2D: 4D ratio to add to our understanding of personality and personality assessment. Discussion Consistent with predictions, those with lower finger ratio scored higher on the informant report of leadership, and those with higher self-report of leadership also scored higher on informant measures of leadership. The lack of significance in comparing solely the self-report leadership and finger ratio shows that the influence of testosterone exposure lies outside the individual’s awareness, but is perceived by close friends and acquaintances. Limitations: Most participants were recruited via convenience. Additional research should likewise change the operationalization of leadership. Future Research: These findings have the potential to be useful in a number of divisions of psychology. Most significantly, the study strengthens research on the 2D: 4D ratio and its ability to provide alternative ways in measuring testosterone. The results also further our understanding of hormones’ influence over personality, and that informant reports of hormonal markers can add new insights. The findings also indicate that informant reports to pre


(Halperin et al., 2018) CyDIVE: Targeted hypermutation system for cyanobacteri> I Active module from EvolvR (Halperin et al., 2018 I Dynamic expression by rhamnose inducible promoter (Kelly et al., 2018 I Extra repression by theophylline riboswitch (inspired by Liu et al., 2020 I Multiplexed gRNA array & counter selection by MazF (Cengic et al., 2022 I Broad host RSF1010 backbone In vivo directed evolution platform development In vitro variant library generation & directed evolution In silico: D1 structural modelling to identify potential engineering target 832 D1 sequences inc. Eukaryotic D1s Structure prediction by AlphaFold2 Global structural alignment by mTM-Align Literature survey on D1 mutagenesis study “Common core” Main variable regions AA222-267 “D-E loop” AA295-317 24 representative D1s structural alignment Evolutionary engineering of Photosystem II: by far, by nature (Oliver et al., 2023) Photosystem II: Ever evolving enzymq I Great knowledge on how standard PS II works, but less on divergent typed I Functional diversity of PS II shaped by natural evolution is reflected in reaction centre protein D1 subunit diversity: Modular tuning mechanism_ I Std D1, D1’ (microoxic), rD1 (?), srD1 (Chl f synthase I Harnessing evolution as an engineering tool: Focusing on D1 as primary target, directed evolution is applied to engineer PS II beyond its known functional horizon Department of Life Sciences, Imperial College London, London, United Kingdom tom.kim@imperial.ac.uk Tom Dongmin Kim§, Daniella Pretorius, Wenxin Li, Francesca Levi & Tanai Cardona Directed evolution of Photosystem II: Status update and structural modelling for targeted engineering


FLORE CLAUS PHD RESEARCH (2020-2026) DEPARTMENT OF CRIMINOLOGY, CRIMINAL LAW AND SOCIAL LAW INDIVIDUAL & COLLECTIVE INTERNATIONAL & NATIONAL W H Y ? Lifelong learning contains all learning activities from the moment you’re born until you die. However, not everyone gets an opportunity to learn throughout their life. Some vulnerable groups are left behind based on who they are (low-skilled, old or disabled) or where they work (sector, seize of the company). Unlike socio-economic (inter)national studies on lifelong learning, little attention is paid to the legal perspective. This doctoral research draws attention to how lifelong learning is integrated in the employment relationship through several regulations, more specifically the legal bottlenecks and possible changes in order to promote lifelong learning for vulnerable groups. Lifelong learning contains all learning activities from the moment you’re born until you die. However, not everyone gets an opportunity to learn throughout their life. Some vulnerable groups are left behind based on who they are (low-skilled, old or disabled) or where they work (sector, seize of the company). Unlike socio-economic (inter)national studies on lifelong learning, little attention is paid to the legal perspective. This doctoral research draws attention to how lifelong learning is integrated in the employment relationship through several regulations, more specifically the legal bottlenecks and possible changes in order to promote lifelong learning for vulnerable groups. NATIONAL & REGIONAL SEMI-STRUCTURED EXPERT INTERVIEWS VIGNETTE METHOD LEGAL ANALYSIS VIGNETTE METHOD LEGAL ANALYSIS LEGAL ANALYSIS LEGAL ANALYSIS L E T ' S T A L K ! Are you intrigued after exploring this topic? Feel free to scan this QR code and share your thoughts, I'm eager to learn from your insights! Interested in some of my findings? Scan this QR-code for my recent research paper (work in progress). Are you intrigued after exploring this topic? Feel free to scan this QR code and share your thoughts, I'm eager to learn from your insights! Interested in some of my findings? Scan this QR-code for my recent research paper (work in progress). W H A T ? Regulation of lifelong learning is scattered at different levels. This unique legal perspective does not focus on one particular regulatory level (national, international...) but includes different policy levels and how they are intertwined. The focus will be on three areas of regulatory tension. Two research questions are central. First, the right to lifelong learning in international context has to be delineated to understand the impact on the regulatory discretion of the national and sub-state levels. The second and main research question, tangles the right to lifelong learning from a bottom-up case study analysis. To align legal findings with real-life experiences of lifelong learning in the workplace, a triangulation of methods will be used. The experiences from five micro-enterprises of three sectors (hospitality, construction and trade) in the Flemish Region will be gathered using the vignette method. Regulation of lifelong learning is scattered at different levels. This unique legal perspective does not focus on one particular regulatory level (national, international...) but includes different policy levels and how they are intertwined. The focus will be on three areas of regulatory tension. Two research questions are central. First, the right to lifelong learning in international context has to be delineated to understand the impact on the regulatory discretion of the national and sub-state levels. The second and main research question, tangles the right to lifelong learning from a bottom-up case study analysis. To align legal findings with real-life experiences of lifelong learning in the workplace, a triangulation of methods will be used. The experiences from five micro-enterprises of three sectors (hospitality, construction and trade) in the Flemish Region will be g


Characterization of Actinobacteriophage LittleTokyo Reveals Variable Diversity Within Cluster AS ●Phages possess incredible genetic diversity; however, there is a very small number of sequenced phages (Pope et al., 2017) ○Many phages are poorly characterized due to a lack of information ○There is limited information on Arthrobacter phages, as only 270 are currently sequenced ●One of the ways in which phages are classified is by placing them into clusters ○Clusters are groups of phages that have high nucleotide sequence similarities, shared life styles, and shared unique genes ●This project sequenced and classified a novel Arthrobacter phage, LittleTokyo ○LittleTokyo belongs to cluster AS ■Has three subclusters: AS1, AS2, and AS3 ■Formed in 2018, when phage Galaxy was found to be sufficiently similar to Abidatro (Klyczek et al., 2018) ●LittleTokyo is a temperate Arthrobacter globiformis phage ●TEM revealed LittleTokyo is a member of the Siphoviridae family through its icosahedral head diameter and tail length ●39.73% of genes were not assigned a function ●ANI heatmap and SplitsTree analyses show LittleTokyo is distinct from the AS2 subcluster ●Full genome Phamerator comparison reveals similarity between LittleTokyo and Kuleana that sets them apart from the AS2 subcluster ●Lysin A and Tape Measure Protein revealed inconsistent evolutionary origins ○In Lysin A, AS1 phages formed the outgroup from AS2 ○In TMP, AS1 phages were more closely related to the rest of the AS2 phages than LittleTokyo or Kuleana ●Evidence of horizontal gene transfer within the genome due to the presence of unique genes ○PAPS reductase-like domain ●Ackermann, HW. Bacteriophages: Methods in Molecular Biology, vol. 501, 2009, pp. 127-140. ●Dereeper, A. et al. Nucleic Acids Res, vol. 36, no. 2, 2008, pp. 465-469. ●Huson, DH. Bioinformatics, vol. 14, no. 1, 1998, pp. 68-73. ●Klyczek, KK. et al. Genome Announc, vol. 6, no. 5, 2018, pp. 1474-1517. ●Krumsiek, J. et al. Bioinformatics, vol. 23, no. 8, 2007, pp. 1026-1028. ●Papadopoulos, JS. and Agarwala, R. COBALT Bioinformatics, vol. 23, no. 9, 2007, pp. 1073-1079. ●Pope, WH. et al. mBio, vol. 8, no. 4, 2017, pp. 1069-1117. ●Savage, H. et al. Cell, 1997, vol. 5, pp. 865-906. ●Yoon, SH. et al. Antonie van Leeuwenhoek, vol. 110, 2017, pp. 1281-1286. Figure 1. LittleTokyo Genome Map A gene map of LittleTokyo was made using Inkscape and LittleTokyo’s genome from Phamerator. Highlighted genes represent genes of interest that were examined later in this project. The genome is 38969 base pairs long with 73 genes, 44 of which were assigned functions and 29 of which could not be assigned a function. Gene product functions were determined through Phamerator, PhagesDB, HHpred, the NCBI Basic Local Alignment Search Tool (BLAST), and the NCBI Conserved Domains Database (CDD). Annotated Genome of LittleTokyo Figure 2. TEM of LittleTokyo Transmission electron microscopy of LittleTokyo. Tail morphology was indicative of the Siphoviridae family. The tail was approximated to be 130 ± 2 nm and the head diameter was estimated to be 50 ± 2 nm. LittleTokyo Morphology Figure 3. Phamerator Genome Comparison Alignment of LittleTokyo’s genome with AS2 phages created through Phamerator and Inkscape. Comparison of LittleTokyo’s whole genome sequence to AS2 phages reveals higher synteny between LittleTokyo with Kuleana and slightly lower synteny compared to the other phages in the AS2 subcluster. (A) (B) Genome Comparison of Cluster AS2 Phages LittleTokyo is Distinct From Other Phages in Subcluster AS2 Figure 4. Phylogenetic Relationships of Cluster AS A Nexus file containing the shared gene content of the cluster AS and AZ phages was created using PhamNexus, which was used to create a SplitsTree diagram (Huson & Bryant, 2006). The AZ phages were included as an intercluster reference. In the tree, LittleTokyo and Kuleana are located on separate branches from the rest of AS2. The tree shows that LittleTokyo and Kuleana branch separately from o


Method and data treatment Reanalysis of Titan INMS mass spectra Results About the homopause References Titan’s ionosphere was sampled by the mass spectrometer of the Cassini spacecraft many times during the course of the mission. Mass spectrometer analysis can be complicated, and identifying in which way a specie contribute to a mass peak is challenging. It is easier to fit the most abundant species, and trace species are often left unanalysed. Here we focus our work for now on 3 major species (N2,CH4, H2) and 1 trace specie (Ar). Consequences and prospectives Maélie Coutelier1, Thomas Gautier1, Koyena Das1, Joseph Serigano2 : maelie.coutelier@latmos.ipsl.fr 1 : LATMOS/IPSL, CNRS, Sorbonne Université, UVSQ, Guyancourt 2 : Morton K. Blaustein Department of Earth and Planetary Sciences, Baltimore 1: Cui, Jun, et al. "Analysis of Titan's neutral upper atmosphere from Cassini Ion Neutral Mass Spectrometer measurements." Icarus 200.2 (2009): 581-615. 2: Cui, J., et al. "The CH4 structure in Titan's upper atmosphere revisited." Journal of Geophysical Research: Planets 117.E11 (2012) 3: Mandt, Kathleen E., et al. "Ion densities and composition of Titan's upper atmosphere derived from the Cassini Ion Neutral Mass Spectrometer: Analysis methods and comparison of measured ion densities to photochemical model simulations." Journal of Geophysical Research: Planets 117.E10 (2012). 4: Magee, Brian A., et al. "INMS-derived composition of Titan's upper atmosphere: analysis methods and model comparison." Planetary and Space Science 57.14-15 (2009): 1895-1916. 5: Teolis, B. D., et al. "A revised sensitivity model for Cassini INMS: Results at Titan." Space Science Reviews 190.1 (2015): 47-84. 6: Gautier, Thomas, et al. "Decomposition of electron ionization mass spectra for space application using a Monte‐Carlo approach." Rapid Communications in Mass Spectrometry 34.8 (2020): e8684. Aknowledgment The funding for this research was provided by ANR (ANR “TOMTA”- ANR-20-CE49-0004-01) and PNP ●Calibration of INMS data using recommendations from previous works1,2,3,4,5 ●MS deconvolution code6 → Randomisation of the species fragmentation patterns between the allowed incertitudes → Monte-Carlo simulation. The code then try to fit at once all m/q peaks using the species in our database. → 100000 simulations → Allowed incertitude of 5% for the major species, and 30% for Argon. → Mean of the 5% best simulations. Global scale temporal variation clearly visible → Steady decrease of N2 mixing ratio and density until the vernal equinox. It increases until 2014 then decreases again. → Nightside/Dayside and Latitude/Longitude effects on the global scale variation are minor. Influence of the solar flux → N2 mixing ratio and density increase with periods of intense solar flux. → CH4 density increases with periods of intense solar flux, but proportionally less than N2. N2 → Isotope ratio 14N/15N = 197 ± 1.3 constant over the years. → Mixing ratio decreases when altitude increase. → molecular density changes with time. Figure 3: Nitrogen density (cm-3) as a function of altitude and time. The gray line is the solar F10.7 cm flux in solar flux units. N2 molecular density (cm-3) Vernal equinox 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 Figure 2: Mixing ratios of Nitrogen, Methane, Argon and Hydrogen as a function of time and altitude. Vernal equinox 9.03 AU Increasing Saturn-Sun distance 10.04 AU Figure 1: 100000 simulations of gases mixing ratio results for flyby T126 at each altitude (low to high altitudes represented as a colour variation from yellow to blue). Figure 4: Mixing ratios of Nitrogen for flyby T27, T43, T59, and T83 used in our analysis. The gray area represents the altitude of the homopause graphically determined. Figure 5: Homopause altitude as a function of time. →Homompause altitude globally decreases over the years. → The altitude variations of the homopause follow the mixing ratio variations between each flyby. How to determine


` ESA space debris studies: hypervelocity impact sample Photo Published on Twitter 12/4/21 Recent Experiments by European Space Agency Highlight Importance of Hydrocode Modeling PISALE simulations of off-normal impact of steel projectile on Al capture full 3D affects ABSTRACT: The solution of partial differential equations (PDEs) on modern HPC platforms is essential to the continued success of research and modeling for a wide variety of areas, especially groundwater flow and transport modeling in Pacific islands. The project implements an innovative combination of advanced mathematical techniques of Arbitrary Lagrangian Eulerian (ALE) methods with Adaptive Mesh Refinement (AMR), including parallel software tools to dynamically adapt the grids and special Lagrangian-flow methods that allow for the simulation of complex regional groundwater flow with dynamic freshwater and seawater interaction in heterogeneous volcanic rocks. The PISALE (Pacific Island Structured-AMR with ALE) software aims at a publicly available sustainable branch of the software and will provide accurate and scalable simulations of complex groundwater flow processes in the Hawaiian islands. The status of our ongoing project will be presented with student involvement, course development, and future plans. Other applications of PISALE are discussed as well. Student Involvement, Broader Impact, and Future Plans Course Development UH CEE 696-003 “Advanced Modeling in Groundwater Engineering” was offered in Fall 2022. The course delivered the concept/theory of ALE-AMR with a few PISALE applications. Future Plans • Flow module will be added and coupled with solute transport equations • The accuracy and scalability for island-scale freshwater-seawater interaction application will be tested Groundwater Flow and Transport Application in Hawaiian Aquifers Preliminary Results Motivation Kona, HI from NSF ‘Ike Wai project Rotzoll et al., 2010 Groundwater is the major source for public supply in Hawaiʻi. Groundwater resources exist as freshwater lens floated on top of seawater. However, groundwater availability is limited by recharge/precipitation and seawater intrusion. Current drought conditions and future sea level rise will impact the freshwater resources in Hawaiʻi. The PISALE project will support island-scale numerical simulation of density-driven flow and transport : 1. to evaluate groundwater availability 2. to design sustainable water use planning 3. to understand the effect of climate change and sea level rise on island water resources Mathematical Model for Density-Driven Flow Groundwater Flow head h(ρ), velocity v (LLNL’s MFEM) Salt Transport c(v) Methodology Flow and Transport with Heterogeneous Hydraulic Conductivity Field t = 0 [yr] t = 12.6 [yr] t = 25.2 [yr] PI Koniges hosted a PISALE workshop for researchers from U of Minnesota during ICCFD11 (left). Outreach efforts on Maui where PI Koniges and colleagues show current and old HPC hardware to local students (Right) Additional and Proposed PISALE Applications Seeded by NSF Funding • As a direct result of our NSF CSSI funded project we now have new application areas using the PISALE Framework: ALE (Arbitrary Lagrangian Eulerian) dynamics and structured AMR (Adaptive Mesh Refinement) Experiment Workshop & Outreach: Acknowledgement We would like to thank many additional members of the PISALE team. The PISALE code applications are supported by the National Science Foundation, under Office of Advanced Cyber Infrastructure Award Number 2005259, the U.S. Department of Energy, Office of Science, under Fusion Energy Sciences Research Division Award Number DE-SC0021374, and the Office of Naval Research, under ONR MURI Award Number N00014- 20-1-2682. This research used resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility located at Lawrence Berkeley National Laboratory, operated under Contract No. DE-AC02-05CH11231 using NERSC awar


RESEARCH POSTER PRESENTATION DESIGN © 2019 www.PosterPresentations.com Project Description To: Project Framework Methodology Anticipated Results University of Pretoria, u17367311@tuks.co.za Tendai Mataranyika SA Universities Institutional Repositories Publications Mapping and UNSDGs Classification Nexus Open Repositories Conference 2023, Cape Town, South Africa Research Output Clustering OpenAIRE Repository Data Sources SDG Classification Service This project still in its early stages seeks to map Institutional Repositories of selected South African universities through clustering and classification using the SDG classification service. This mapping will provide insight on which SDG research themes have been worked on by which universities. Information derived from this project will feed other research consuming communities and policy makers interested in understanding how Higher education contribute to development initiatives.


Use of barcoding, from theory to practice (PRACTIBAR) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 207 000 Picture 1 Picture 1 Picture 1 Goals The main goal of the project is to raise awareness on barcoding as a generic method for pest identification and to train experts of the competent organisations, as highlighted at the end of the Euphresco project and as recommended by the EPPO Panel on Diagnostics and Quality Assurance in 2016-01- 19/21. Workshops and proficiency tests (PT) will be organised and training material developed. Research consortium EPPO (INT), AGES (AT), ILVO (BE), CFIA (CA), AU (DK), ANSES (FR), JKI (DE), SASA (GB), VAAD (LV), NVWA (NL), INIAV (PT), APHIS (US), UG (CA), FA (RS) Contact information Project coordinator: Françoise Petter fp@eppo.int Baldissera Giovani bg@eppo.int Objectives and key outputs Workshops will be organised in the framework of the project that will allow participants to be informed of the most recent advancements on the method and to receive training on a number of tools for data analysis: sequencing analysis softwares that allow assembly of raw sequence data (e.g. Geneious), online databases (Q- bank, NCBI, BOLD). Raw sequence data will cover examples from arthropods, bacteria, fungi, invasive plants, nematodes, phytoplasmas, viruses and viroids, depending on the needs and wishes of the workshops’ participants. A proficiency test will be organised at the conclusion of the workshops to determine the performance of individual laboratories. 05/2017-04/2019


Chair of Waste Processing Technology and Waste Management (AVAW) Department of Environmental and Energy Process Engineering Montanuniversität Leoben (MUL) Franz-Josef-Strasse 18, 8700 Leoben, Austria E-Mail: avaw@unileoben.ac.at, Homepage: avaw.unileoben.ac.at DTU Sustain Department of Environmental and Resource Engineering Danmarks Tekniske Universitet (DTU) Bygningstorvet, Building 115, 2800 Kgs. Lyngby, Denmark Homepage: sustain.dtu.dk/en/om-os Consumers confused: Where to throw the compostable plastic? Namrata Mhaddolkar (MUL & DTU), Alexia Tischberger-Aldrian (MUL) The project C-PlaNeT has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska Curie grant agreement No. 859885. Background: • Starting 1st January 2020, plastic bags were banned in Austria; except for biodegradable bags. • According to Austrian compost ordinance, certified compostable dustbin bags could be thrown along with the biowaste. • Waste sorting guidelines instruct: compostable plastic packaging & bags to be disposed in lightweight packaging or residual waste bin. Visual identification method: Research question: What kind of compostable plastics were found in the lightweight packaging, organic, & residual waste in Austria? Lightweight packaging waste: Residual waste: Obtaining samples: • 27 samples from reject material from plastic waste sorting facility. • Samples collected from falling conveyer belt. Items found: • Supermarket carrier bags (majority), packaging for carrots, packaging nets from wood-fibre for onions, and dustbin bags. • No PLA material was found. • Some bags without proper labelling were found. Organic waste: Obtaining samples : • 27 samples from input material to composting facility. • The compost pile was divided into three parts based on length, and samples were taken from each section. Items found: • Dustbin bags (majority), packaging for carrots, and supermarket carrier bags. • No PLA material was found. • Some bags without proper labelling were found. Obtaining samples : • 27 samples from input material to residual waste handling facility. • Samples collected via quartering method. Items found: • Supermarket carrier bags (majority), packaging nets from wood-fibre for onions, dustbin bags, and take-away food packaging from PLA material. • Some bags without proper labelling were found. References: • Altstoff Recycling Austria AG. (2022). PACKSTOFFE AUF BIOLOGISCHER BASIS [Press release]. Wien. https://www.ara.at/uploads/Dokumente/Info- Merkbl%C3%A4tter/ARA-IB-Packstoffe-auf-biologischer-Basis-2022.pdf • Verordnung des Bundesministers für Land- und Forstwirtschaft, Umwelt und Wasserwirtschaft über Qualitätsanforderungen an Komposte aus Abfällen (2001). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnorm en&Gesetzesnummer=20001486 • Federal Ministry Republic of Austria. (2020). Plastic bag ban in Austria as from 2020. Federal Ministry Republic of Austria - Climate Action, Environment, Energy, Mobility, Innovation and Technology. https://www.bmk.gv.at/en/topics/climate-environment/waste- resource-management/waste-prevention/plastic-bag.html • Sametinger, S. (2017). Entsorgung von Bioplastik. ichbinsoplastikfrei. https://www.ichbinsoplastikfrei.at/grosse-unsicherheit-bei-der- entsorgung-von-bioplastik/ • COMMUNICATION FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT, THE COUNCIL, THE EUROPEAN ECONOMIC AND SOCIAL COMMITTEE AND THE COMMITTEE OF THE REGIONS (2022). https://environment.ec.europa.eu/publications/communication-eu- policy-framework-biobased-biodegradable-and-compostable- plastics_en • Image Sources: www.european-bioplastics.org; www.tuv-at.be; www.dincertco.de; www.showsbee.com Namrata Mhaddolkar namrata.mhaddolkar@unileoben.ac.at; namha@dtu.dk Webseite: LinkedIn (Scan the QR Code) Conclusion: • Similar kinds of compostable plastics were found in all three waste streams, although the quantities differed. • Even with labeling, consumers found confused w


Age-Associated Changes in Urothelium-Dependent ATP Release Advancing Understanding of Overactive Bladder Syndrome (OAB) Pathophysiology Ayse Gurpinar, Maxwell Roberts, Lisiane Meira, Patrizia Camelliti and Changhao Wu Department of Biochemistry, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH,UK Normal bladder function relies on release of ATP from the urothelium (epithelial lining of bladder) [1]. This ATP communicates the degree of bladder fullness to the central nervous system. As a key regulator of urinary bladder sensation, disturbed release of this ATP is believed to contribute to pathophysiology of OAB [1]. Introduction Documented Key Evidence Prevalence increase with age for both sexes [1] Affects 30% of people over 65 years worldwide [2] Costs the NHS nearly £2 billion every year [3] Patients exhibit increased stretch-induced urothelial ATP release [4] Patients exhibit increased urothelial secretion of neuropeptides associated with inflammation [4] Methodology Hypothesis: Inflammatory mediators can modulate urothelial function via specific pathways during bladder ageing, contributing to aetiology of OAB. Animal model: Young (12-33 weeks) and aged (>80weeks) male C57BL/6 wild type mice. 1. Longitudinal full-thickness tissue strips were prepared via microdissection and fixed within organ bath with continuous perfusion 2. Superfusate samples were collected at specific times and tested for ATP content via Luciferin-Luciferase assay 3. Interventions used: Substance P (SP: inflammatory neuropeptide), Interleukin- 1α (IL-1α: pro-inflammatory cytokine), Thapsigargin (TG: raises intracellular Ca2+) and Staurosporine (STS: Protein kinase C (PKC) inhibitor) Results  Aged bladders exhibit variations in some pathways  Inflammation (IL-1α and SP) can induce urothelial ATP release in both young and aged bladders  PKC signalling dysfunction (STS) can be associated with augmented ATP release in aged bladders  Aged bladders might be associated with dysregulation of intracellular Ca2+ (TG) for ATP release Conclusions 1. Silva-Ramos⁎, M., Silva⁎, I., Oliveira, O., Ferreira, S., Reis, M., Oliveira, J. and Correia-de-Sá, P., 2013. Overactive bladder syndrome: Evidence that urinary ATP is a dynamic biomarker of detrusor overactivity. Autonomic Neuroscience, 177(1), pp.21- 22. 2. Puckering, G., Walker, D., Xu, L., Congdon, P. and Gooch, K., 2019. The Prevalence and Forecast Prevalence of Overactive Bladder in the Medicare Population. Clinical Medicine Insights: Urology, 12, p.117956111984746. 3. Ganz ML, Smalarz AM, Krupski TL, Anger JT, Hu JC, Wittrup- Jensen KU, et al. Economic Costs of Overactive Bladder in the United Kingdom. Urology [Internet]. 2010 Mar [cited 2020 May 5];75(3):526–32, 532-18. 4. Nässel, D., Zandawala, M., Kawada, T. and Satake, H., 2019. Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic. Frontiers in Neuroscience, 13. References Acknowledgements This study is University of Surrey, NIH [1R01AG049321- 01A1] and BBSRC [BB/P004695/1] supported. All the experiments mentioned above fulfil the ethical requirements. Figure 2.Illustrates the experimental set up. The arrow indicates orientation of the tissue strip in the organ bath. Figure 1. Depicts OAB phenomena [1]. Young Wild Type Figure 3. Data are expressed as median±interquartile range and tested by Wilcoxon’s. (SP[n=10]: con - 8[5,19] SP - 11[7,27] *p<0.05, IL-1α[n=14]: con- 12[5,26] IL-1α- 14[6,43] **p≤0.01,TG[n=13]: con- 11[8,14] TG- 15[7,20] * p<0.05, STS[n=15]: con- 11[6,19] STS - 13[6,26] NS p>0.05). Aged Wild Type Figure 4. Data are expressed as median±interquartile range and tested by Wilcoxon’s. (SP[n=9]: con - 6[4,19] SP - 15[8,39] **p≤0.01, IL-1α[12]: con- 6[4,15] IL-1α- 18[4,31] *p<0.05,TG [n=11] con-12[4,15] TG-9[6,20] NS p>0.05, STS[n=14]: con- 7[4,10] STS- 12[6,14] *p≤0.05). SHAPING FUTURES : This is the first project to compare the effect of inflammation on ATP release in


KARMA.edu 1 - :مقدمــــــــة توفرKarma. edu لإلرشاد األكاديمي مجموعة متنوعة من األساليب التعليمية والخدمات والموارد المقدمة للطالب في محاولة لمساعدتهم على تسريع تقدمهم في التعلم و اللحاق بأقرانهم و تلبية معايير التعلم في الجامعة . 2 - ـ ال رؤيــــــــــا : تمكين الطالب من أن يكونوا متعلمين نشطين ومسؤولين يستفيدون بشكل كامل من العديد من الفرص التي توفرها الجامعة في كل من البيئات األكاديمية والمشاركة المجتمعية . 3 - :المهـمــــــة من خالل الشراكات المهنية الداعمة والتعاونية مع ،الطالب يكرس المستشارون األكاديميون جهودهم لتعليم الطالب كيفية الوصول إلى المعلومات األساسية واكتساب المهارات الالزمة التخاذ قرارات مستنيرة تؤدي إلى تحقيق أهدافهم التعليمية والوظيفية والحياتية. 4 - :القيـــــم يلتزم المستشارون األكاديميون بتقديم خدمات استشارية عالية الجودة وشاملة تلبي االحتياجات الفريدة لكل ،طالب ويكرس طاقم اإلرشاد األكاديمي جهوده لتهيئة بيئة تدعم متطلبات الطالب. 5 - :األهــــــداف • دعم ثقة الط الب بأنفس هم ومساعدته م كذلك اكتشاف قدراته م وا مكانياته م الدراسية وتطوير مهاراتهم لل تكيف مع بيئته م الدراسية واالجتماعية والعلمية والتغلب على أية صعوبات قد تعترض مساره م الدراسي. • تنمية وتطوير مهارة التخطيط لدى الطلبة ليطبقوا الخطة الدراسية المالءمة والمناسبة لهم. • تنمية وتطوير قدرة الطلبة على تحديد أهدافهم واختيار التخصص الذي يتالءم وقدراتهم وميولهم. • تنمية مهارات تنظيم واستثمار الوقت.


, Our infrastructure automates ﬁtting, allowing force ﬁeld science and driving innovation Open Force Field: Improving the accuracy and applicability of open molecular models OpenFF partners with industry to build accurate, pre-competitive force ﬁelds for general use OpenFF 2.0.0 (Sage) is a leading public small molecule force ﬁeld OpenFF Toolkit Interchange External components BespokeFit Topology SMIRNOFF force ﬁeld (.offxml) Chemical structure ﬁle(s) (SMILES, .PDB, .SDF, etc.) Plugins ForceField SMIRNOFF: Assign parameters directly to chemistry Use of industry-standard SMARTS/SMIRKS chemical perception greatly simpliﬁes tooling for parameter assignment while solving issues with extensibility and ﬂexibility Protein parameters Rosemary OpenFF-3.0.0 Sage OpenFF-2.2.0 Parsley OpenFF-1.2.0 Parsley OpenFF-1.3.0 Sage OpenFF-2.1.0 Water model and ion parameters Rosemary OpenFF-3.1.0 Neural network charges Automated chemical perception General polarisability General neural network force ﬁeld Surrogate modelling Parsley OpenFF-1.1.0 Parsley OpenFF-1.0.0 First OpenFF force ﬁeld Sage OpenFF-2.0.0 Re-trained van der Waals’ 2019 – 2022 2023 2024 Thyme OpenFF-4.0.0 Virtual sites and BCCs Alternate functional forms Jeffrey Wagner, Open Force Field ACADEMIC INDUSTRY AbbVie Amgen Bayer Cresset Eli Lilly Janssen John Chodera (MSKCC) Michael Gilson (UC San Diego) David Mobley (UC Irvine) Michael Shirts (CU Boulder) OpenEye Pﬁzer Redesign Roche Ventus Vertex … and others Afﬁliates Simon Boothroyd (Psivant) Chapin Cavender (UCSD) Connor Davel (CU Boulder) Danny Cole (Newcastle) Lorenzo D’Amore (Janssen) Dennis Della Corte (BYU) PROJECT STAFF Lily Wang - Science Lead Jeff Wagner - Technical Lead Matt Thompson - Software Scientist David Dotson - Software Scientist Alexandra McIsaac - Staff Scientist Brent Westbrook - Staff Scientist Josh Mitchell - Scientiﬁc Communicator James Eastwood - Project Manager Trevor Gokey (UCI) David Hahn (Janssen) Josh Horton (Newcastle) Tobias Hüfner (UCSD) Meghan Osato (UCI) Ben Pritchard (MolSSI) Willa Wang (UCSD) Jeffry Setiadi (UCSD) Lee-Ping Wang (UCD) Yuanqing Wang (NYU) Marcus Weider (MSKCC) Prototype now available (*not the most up-to-date model!) OpenFF NAGL will use ML models to rapidly assign partial charges, even to large molecules Fitting self-consistent parameters for proteins and small molecules Null model: trained with extra data, no additional parameters Speciﬁc model: trained with extra data with additional parameters Performance equivalent to Sage Proﬁle shape mismatch Virtual sites are now a top priority for small molecule improvement HF/6-31G* Sage With virtual sites RMSD (A) length=1.469 A k=467.3 kcal/mol/A**2 The OpenFF community shares insights, experiences, code and workﬂows. More than a dozen industry partners participate. Contact: info@openforceﬁeld.org The OpenFF Software Ecosystem Where we’ve been and where we’re going Software and standards in the OpenFF ecosystem How to join OpenFF as an industrial partner Gapsys et al. JCIM 2022 Boothroyd et al. JCTC 2023 D’Amore et al. JCIM 2022 2023 OpenFF Keynote The SMIRNOFF speciﬁcation OpenFF-2.1.0 our most recent FF Notebook using NAGL prototype New wayﬁnding documentation


I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 EMG-based decoding of motor tasks in amputees using a minimal set of EMG electrodes. F. Barberi* f.barberi@sant annapisa.it F. Aprigliano* f.aprigliano@san tannapisa.it E. Gruppioni° e.gruppioni@i nail.it A. Davalli° a.davalli@inail .it R. Sacchetti° r.sacchetti@in ail.it A. Mazzoni* a.mazzoni@sa ntannapisa.it S. Micera* s.micera@sant annapisa.it *The BioRobotics Institute, Scuola Superiore Sant’Anna, Pisa, Italy °INAIL Prosthesis Center Vigorso di Budrio (BO), Italy Abstract— Lower-limb powered prostheses have been widely studied and optimized over the years to help amputees improving their life quality and their walking performances during different motor tasks. Prostheses control can rely on various kinds of sensors, like inertial sensors and accelerometers. Among these, electromyographic (EMG) - control of powered prostheses seems to be a promising approach. In this study, we recorded EMG signals from four muscles (i.e. Adductor, Tensor Fasciae Latae, Rectus Femoris and Biceps Femoris) of the stump of thirteen transfemoral amputee patients while they were performing five motor tasks: ground level walking, stairs ascending, stairs descending, ramp ascending and ramp descending. Recorded signals were processed and the mean absolute value (MAV) was extracted over a 20ms moving window. Post-processed signals were then used as input of a Support Vector Machine-based algorithm to classify the motor tasks. The algorithm followed two steps of decoding of motor tasks, classifying ground level walking tasks first, and trying to identify stairs ascending, stairs descending, ramp ascending and ramp descending afterwards. Results showed that it was possible to identify motor tasks with one single muscle, with an accuracy ranging between 70% and 83%. Increasing the number of muscles used for the classification led to higher performances: combining EMG from three or four muscles resulted in performances above 90%. These results proved that it is possible to reliably decode motor tasks with a EMG-based algorithm relying on as little as three recording sites, ensuring a minimum discomfort of the system for the users. Keywords — EMG, classifier, prosthesis, decoder, lower limb I. INTRODUCTION Lower-limb amputees experience a general low confidence while using their prostheses, expecially during challenging motor tasks. This leads to a bad distribution of their weight and asymmetric walking patterns, increasing the chances of suffering from back pain and joint degeneration [1]. Prostheses differ in the degree of assistance that they provide to the users. Passive prostheses do not actively assist the users and are used just as a physical support. Semi-active prostheses provide assistance adapting the stiffness of their joints based on the gait modality. Powered prostheses actively participate in the movement, changing the position of the prosthetic joints based on the performed activity. The actuation of these prostheses can be based on information exctracted from sensors like gyroscopes, accelerometers, goniometers, electromyographic (EMG) electrodes etc [2]. Using EMG signals can allow high degrees of voluntary control of the prosthesis. EMG signals were widely used to control ankle-foot prostheses in transtibial amputees [3]. EMG-controlled powered knee prostheses is still an open challenge, and many studies investigated this kind of control by using both EMG signals alone or in combination with other sensors [4]. Many studies used high number of EMG electrodes [5]. This can be in some cases difficult to implement, depending on the type and length of the amputation. In this study, a new decoding algorithm was implemented and tested on electromyographic signals collected from 13 transfemoral amputees. We investigated which was the minimum number of EMG electrodes that could guarantee high performances of the classification algorithm while maintaining minimum discomfort i


Oliver Hahn E-Mail: o.hahn@zbw.eu Steffen Lemke E-Mail: s.lemke@zbw.eu An Exploration of Scientific Press Releases in the Context of Altmetrics Address: Düsternbrooker Weg 120, 24105 Kiel, Germany Introduction Dataset & Methods Press releases are published by organizations to bring attention to achievements they have reached. In the scientific domain, for example research institutions, funders, and academic publishers make use of press releases to advertise newly published papers and particularly promising scientific results. For altmetrics research, which analyzes the presence of scientific objects in various public domains like for instance social media, news, or policy documents, so far press releases have been an almost unregarded albeit promising source of data (Bowman & Hassan, 2019). Also, previous studies have shown a strong association between a journal article receiving promotion in a press release and its later citations and altmetrics (Lemke, 2020), further warranting a precise look at this communication format’s characteristics. We set out to explore two large samples of science press releases to gain further insights on their contents, creators, and role in the communication of research. Our data consists of two samples of press releases published over one year between April 2016 and March 2017. Two randomly chosen subsamples of 100 press releases each were used for content analysis by two independent raters.  1,856 press releases from IDW-Online  average length of press release: 724 words Subjects Disciplines assigned to press releases by IDW -Online. Frequent occurrences: Biology (13.67%), Medicine (11.13%), Environment and Ecology (7.76%), Chemistry (6.57%), Physics (incl. Astronomy) (6.35%). Topics The 50 most frequent word stems in the titles of press releases. The Porter Stemming Algorithm was used. Content Analysis — Press Release Texts From each dataset, 100 random press releases were examined for mentions of… … or if they did not mention any specific study at all (No Research). … featured studies‘ Methods, … their Limitations, Content Analysis — Releasing Institutions Oliver Hahn & Steffen Lemke ZBW — Leibniz Information Centre for Economics  founded in 1996 by the American Association for the Advancement of Sciences  14,000+ registered journalists from 90+ countries (de Vrieze, 2018)  founded in 1995 by a coalition of press officers from German universities  8,000+ registered journalists (likely predominantly German-speaking) EurekAlert! IDW-Online Portals for publication of science news– and press releases.  26,358 press releases from EurekAlert!  average length of press release: 755 words EurekAlert! IDW-Online Disciplines based on Scopus subjects of 10,483 journal articles promoted in the press releases. Frequent occurrences: Life Sciences (13.95%), Health Sciences (12.79%), Medicine (12.59%), Biochemistry (9.27%), Genetics and Molecular Biology (9.27%), Physical Sciences (7.55%), Agricultural and Biological Sciences (5.20%). EurekAlert! & IDW-Online … the findings‘ immediate practical Implications, … other studies, researchers or institutions not directly involved in the featured study (References), EurekAlert! IDW-Online Conclusion & Future Work  Press releases on both EurekAlert! and IDW-Online are dominated by life sciences, followed by physical sciences; other subjects are rare  They frequently describe featured studies’ methodologies and often also practical implications, descriptions of limitations or references to other research are less typical  Structurally, press releases seem to be a comparatively homogeneous format of external science communication, e.g. compared to news articles  Regarding the institutions submitting press releases, our analysis suggests substantial differences between both platforms: while universities account for large shares of the submissions to both portals, EurekAlert! seems to be shaped more by publishers and journals, while IDW-Online features many c


POŠKOZENÍ LANGERHANSOVÝCH OSTRŮVKŮ MIKROPORACÍ S siRNA A BEZ siRNA Tomšovská V. 1,4, Fábryová E.1,4, Leontovyč L.1, Plecitá-Hlavatá L.3, Holendová B.3, Špitálníková Veřtátová M.1, Girman P 2. Berková Z 1, Kříž J 2. 1Laboratoř Langerhansových ostrůvků, CEM, IKEM, Praha 2Centrum diabetologie, IKEM, Praha 3Laboratoř pro výzkum pankreatických ostrůvků, Fyziologický ústav AVČR, Praha 41.Lékařská fakulta, UK, Praha Úvod: Mikroporace je jednou z transfekčních metod využívajících elektrické pulzy. Lze ji použít pro zavedení nukleových kyselin (NK) do buněk. Pomocí krátkých elektrických pulzů se vytvoří mikropóry v buněčné membráně, kterými NK mohou vstoupit do buněk. Testovali jsme potenciální škodlivé účinky této metody pro transfekci siRNA do buněk Langerhansových ostrůvků (LO). Metody: Mikroporace je jednou z transfekčních metod využívajících elektrické pulzy. Lze ji použít pro zavedení nukleových kyselin (NK) do buněk. Pomocí krátkých elektrických pulzů se vytvoří mikropóry v buněčné membráně, kterými NK mohou vstoupit do buněk. Testovali jsme potenciální škodlivé účinky této metody pro transfekci siRNA do buněk Langerhansových ostrůvků (LO). Výsledky: Všechny provedené testy ukázaly neporušenou funkci beta buněk bez rozdílu mezi mikroporovanými a kontrolními LO. Schopnost uvolňování inzulinu během perifuzního testu a rychlost spotřeby kyslíku nebyly porušeny. Při použití fluorescenčního testu integrity membrán bylo procento mrtvých buněk v LO: 15,9 % u mikroporace s siRNA, 13,7 % u mikroporace a 10,6 % u kontroly. qRT-PCR analýza produkce zánětlivých faktorů rovněž neprokázala rozdíly mezi vzorky. Závěr: Mikroporace nepoškozuje Langerhansovy ostrůvky a zdá se být bezpečnou technikou pro transfekci siRNA do buněk Langerhansových ostrůvků. Podpořeno projektem Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Program EXCELES, ID: LX22NPO5104) – Financováno Evropskou unií – Next Generation EU. Podpořeno MZ ČR – RVO („Institut klinické a experimentální medicíny – IKEM, IČ 00023001“)


Aidin Niamir and Joy Kumagai Senckenberg Society for Nature Research Rainer M. Krug University of Zurich IPBES goes FAIR & CARE! Data and Knowledge Management Policy Adapted For further enquiries on IPBES data and knowledge management policy contact tsu.data@ipbes.net Since December 2019, Senckenberg Society for Nature Research has hosted a technical support unit for data, which supports the task force on knowledge and data with matters relevant to data management at IPBES. Two years have passed since the Multidisciplinary Expert Panel and the Bureau of the Intergovernmental Science‐ Policy Platform on Biodiversity and Ecosystem Services (IPBES) approved the IPBES Data Management Policy. Since then, the policy has been implemented within the Platform and revised to explicitly include considerations of the handling of indigenous and local knowledge. Inclusivity and collective benefit as it relates to open science are now recognized as guiding principles in the policy. To inform implementation, the CARE principles for Indigenous Data Governance now compliments the FAIR principles for scientific data management and stewardship. With the inclusion of these concepts and responsibilities, the IPBES data management policy has been renamed to the IPBES data and knowledge management policy. The IPBES data and knowledge management policy aims to improve the accessibility of products, transparency of the underlying processes to create them, and the CAREful handling of Indigenous and local knowledge within IPBES. https://doi.org/10.5281/zenodo.3551078 Data and Information Management Plan Approved IPBES 3 January 2015 Knowledge and Data Task Force decides to draft a data management policy March 2019 Data Management Policy v 1.0 Approved 14th Meetings MEP/Bureau January 2020 Data Management Policy v 1.1 Approved 15th Meetings MEP/Bureau November 2020 Plenary takes note of Data Management Policy v 1.0 IPBES 8 June 2021 Data and Knowledge Management Policy draft v 2.0 Reviewed 17th Meetings MEP/Bureau November 2021 Data and Knowledge Management Policy v 2.0 Approved 18th Meetings MEP/Bureau February 2022 History of the policy Annexes of the policy 1. Definitions Glossary of the key terms used 2. Implementation Resources • Series of Technical Guidelines https://ict.ipbes.net/data‐ management/technical‐guidelines • Policy tutorials https://ipbes.net/dmp/tutorials • Delivery protocol of the assessment drafts https://doi.org/10.5281/zenodo.5509137 Grounded in: ACCESSIBILITY & OPEN‐SCIENCE • FAIR principles for scientific data management and stewardship https://www.go‐fair.org/fair‐principles • CARE principles of indigenous data governance https://www.gida‐global.org/care


Measurement of the Neutron Total Cross section on Argon in Energy Range of 30-70 keV Jingbo Wang on behalf of the ARTIE collaboration University of California, Davis The Argon Resonant Transport Interaction Experiment (ARTIE) was recently performed at the Time-of-Flight neutron beam at Los Alamos National Laboratory (LANL). ARTIE makes a new measurement of the total cross-section of neutrons on natural argon between 30-70 keV. This measurement is crucial for the Deep Underground Neutrino Experiment (DUNE) as it determines the feasibility of the neutron-based detector calibration technique and provides a deeper understanding of signals and backgrounds for the low energy physics programs. Abstract Neutron Total Cross Section Summary Motivation This work is supported by the Department of Energy, Office of Science and the National Nuclear Security Administration Acknowledgements The Deep Underground Neutrino Experiment (DUNE) is an upcoming US-based international long-baseline experiment for neutrino science. Screen Shot 2020-06-10 at 11.04.11 AM Design of Liquid Argon Target References [1] http://www.dunescience.org [2] R.R Winters, et al., Phys. Rev. C 43 492 (1991) [3] https://lansce.lanl.gov DUNE is the future flagship experiment of the Department of Energy. It will send a neutrino beam from Fermilab in Illinois to Sanford Underground Research Facility in South Dakota [1] The neutron transport in liquid argon is important: 1. Detector calibration: Can we use an external pulsed neutron source to calibrate the far detector? Neutron capture signal could be used as a standard candle energy. 2. Neutron shielding: How much shielding material is needed for suppressing the neutron backgrounds in supernova and solar neutrino programs. 3. Neutrino Physics: Are nearby neutrons useful to achieve better energy resolution during the reconstruction of the supernova neutrinos? ENDF vs Previous Measurement The Lujan Center at the Los Alamos Neutron Science Center (LANSCE) Experimental Setup at LANL Energy [eV] 20000 40000 60000 80000 Cross-section [barn] 1 - 10 1 10 ENDF Ar-nat Winters ARTIE’s target density is 3.5 atoms/barn: blind to high cross sections but sensitive to low-cross sections at 30-70 keV • 168 cm long, 1” OD stainless steel tube • Sealed by Kapton foil windows allowing neutrons to go through • Dry-nitrogen gas-flow-caps used to prevent ice formation on Kapton windows • Liquid level monitored by video cameras and temperature sensors • Thermal insulation provided by Polyurethane foam Need good understanding of neutron total cross section in the range of 30-70 keV • The ENDF prediction of the neutron total cross section on natural argon is ∼0.01 barn at 57 keV, which disagrees with a previous measurement of ~0.1 barn [2]. • Previous Measurement by Winters: o Neutron Transmission Measurement 2.216-meter long gaseous target with a density of 0.211 atoms/barn o Not sensitive to low cross section at energy range of 30-70 keV Liquid Argon Target Foam Insulation Liquid Argon fill Dewar Liquid Argon vent Dewar Gas Cap Gas Flow Gas Flow Gas Cap • Neutron energy determined using the Time-of-Flight technique • The total cross section is measured through neutron transmission TOF neutron detector Vacuum pipe Vacuum pipe Liquid argon target Neutron beam 𝜎! = − " #∗ln 𝑇! = − ! "∗ln #"#$%"# #$%&$%$%& 𝜎!: total cross section at energy bin i 𝑛∗: effective column density of the target 𝑇": transmission coefficient at energy bin i 𝐶"#: 𝑇𝑜𝑡𝑎𝑙𝑛𝑒𝑢𝑡𝑟𝑜𝑛𝑐𝑜𝑢𝑛𝑡for target-in run 𝐵"#: Background count for target-in run 𝐶$%&: 𝑇𝑜𝑡𝑎𝑙𝑛𝑒𝑢𝑡𝑟𝑜𝑛𝑐𝑜𝑢𝑛𝑡for target-out run 𝐵$%&: Background count for target-out run • Neutron beam: Flight Path 13 at Lujan Center at the Los Alamos Neutron Science Center (LANSCE) [3] Proton Target Liquid Argon Target At 30 meter Li-glass Neutron Detector at 65 m Target area at FP13 Measurement Strategy Transmission Measurements: • “Target-out” run with the target tube flushed by gaseous argon • “Target-in” run with the target tube filled with


1 2 3 4 5 6 7 8 9 10 0 2 4 6 8 C O Cu Intensity Energy (keV) Spec 1 Spec 2 Ag Eapp = 0V, tapp = 5 min 1 2 3 8 0 1 2 70 71 72 73 74 75 Ag S Cu Cu O Intensity (a.u) Energy (keV) C Low-power electrically-polarized nanoscale metallic surfaces composed of cupric salt and silver metal exhibited effective deactivation against a broad range of microbes. Six log reduction of five different bacteria – both gram-positive and gram-negative, was observed with electrically-polarized ENM devices. ENM devices were also effective against one viral particle and two medically-relevant fungi tested in the studies. In-situ hydrogen peroxide in micromolar concentration was produced through the oxygen reduction reaction mediated by cuprous ions. The electrochemical steady concentration of cuprous ions in molar concentration over ten days is key to a sustainable production of highly reactive hydroxyl radicals in the solution. These studies add a new toolbox to producing highly reactive oxygenated species by utilizing an external power battery to electrically-polarizing the nanoscale metallic films. 0 10 20 30 40 50 0.0 0.5 1.0 [AA]/[AA]o tapp (min) Control Ag, 0V Ag, 3V ENM, 0V ENM, 3V 350 400 450 500 550 600 0 100 200 300 non-ENM, Eapp= 0V 0 h 48 h 96 h 120 h Intensity (au) Wavelength (nm) 0 60 120 0 1 2 3 4 5 non-ENM 0V ENM 3V [OH.] nanomoles/cm2 tapp (hr) 0.0 0.1 5 10 15 0 8 16 24 32 ENM, 3V non-ENM, 0V Ag, 0V Ag, 3V [Cu(I)] M/cm2 tapp ( 1000 min) 𝐂𝐮+ Accelerated deactivation of broad-range microbes via in-situ generation of reactive oxygenated species M. Aswad Ali1a, Annie Y. Vargas-Lizarazo1a, Tyler Sons2, Michelle Garnett2, Jose Vargas2, Michael Olson3, Philip Jensik4, Scott Hamilton- Brehm2, Punit Kohli1 1Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, USA; 2Department of Microbiology, Southern Illinois University, Carbondale, Illinois 62901, USA; 3Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA; 4Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA; aEqual contributors Abstract Development of new strategies that are effective against a broad range of microbes is a crucial area of research because of dwindling new antibiotics and emergence of antibiotic-resistant microbes. Here, we report on implementing electrically-polarized nanoscale metallic coatings (ENM) that deactivate a broadband microbes including Gram-negative and Gram-positive bacteria with six log reduction, within five minutes of treatment. ENM devices were also effective in the deactivation of a virus and a fungus with high efficiency. Highly damaging in-situ reactive oxygenated species (ROS), including hydrogen peroxide and hydroxyl radicals, were produced by electrically-polarized metallic coatings. A sustainable micromolar ROS concentration was observed for about three days in ENM devices allowing effective antimicrobial surfaces for long-term usages. ENM represents a non-conventional tool providing a highly effective antimicrobial mode of deactivation through the production of highly damaging ROS to microbes. Fabrication of ENM Characterization Conclusion Acknowledgement Microbe Droplet on ENM Deactivation through ROS/Free radical mediated processes triggered by electrical polarization 2. Soaking in Cu2+ 3. Sputtering Ag O2, H2O 𝐞− 𝐂𝐮𝟐+ Battery ENM Method - Deactivation of Microbes by ENM Cu Ka1 & Ag La1 mix Results – Deactivation of Microbes 𝐂𝐮𝟐+/𝐂𝐮+couple mediates formation of ROS by ENM through 𝐂𝐮+diffusion into bulk SEM Mix Map and EDS Confirmation of the Species Present in ENM Water Static Contact Angle Measurements = 118o ± 8o AFM Determination of Thickness Ag Coating and Particle Size Distribution 20 µm 20 µm Non-homogeneity in the Junction of the Fibers-Two Electrode Equivalency Junction of overlapping fibers does not have Ag coating – Prevents shorting Spec 1 Spec


This project has received funding from the Circular Bio-based Joint Undertaking (CBE JU) under the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101112581 APPROACH Waste Characterization and Selection Samples from various pulp and paper industr y processes and organic waste were analysed f or differe nt parameter s. Sampl es wi th t he m ost promising acidification results were selected for further analysis. Various physical and chemical pre-treatments were tested to enhance volatile fatty acid (VFA ) yield . Combinin g multipl e pre-treatment s d id not significantly improve the results. Fermentation tests assessed VFA production efficiency under different pH conditions. Th e predominan t VFA s include d acetic , propioni c, and butyric acids. PRELIMINARY RESULTS The project started in May 2023 and is funded by Circular Bio-Based Europe Joint Undertaking under G.A. No 101112581 . During the first year, significant progress was made in optimising the production of volatile fatty acids (VFAs) from the waste streams. The consortium focused on characterising and selecting suitable waste samples, optimising pre-treatment methods and conducting acidogenic fermentation tests. ELLIPSE project transforms industrial waste into valuable bioproducts by co-processing heterogeneous waste streams. This approach addresses waste from slaughterhouses, the pulp and paper industry, dairy industry sludge, and glycerol, converting them into polyhydroxyalkanoates (PHAs) and bio-based fertilisers (BBFs) for agricultural and personal care applications. INTRODUCTION Optimising fermentation parameters exploring downstream concentration techniques t o enhance VFA production and PHA quality Pilot scale trials that involve scaling up the lab trials to 1 cubic meter, using various mixtures o f dairy waste, bellygrass, and/or waste glycerin e, wi th t he a im to produ ce VFA-ri ch materi al for project partners to utilize. End of life alternative of validated products will be studied to confirm their recyclability an d biodegradability. NEXT STEPS Rafael Jiménez Lorenzo (rajimenez@aimplas.es), Pablo Ferrero (AIMPLAS); Stephen Nolan (Green Generation); Nicola Frison, Chiara Bastianelli (University of Verona); Marco de la Feld, Antonietta Pizza, Martina Calò (ENCO); Ana Lúcia Carolas, Bruno Sommer Ferreira (Biotrend), Patrizio Salice, Sara Guerrini (Novamont); Nydia Badillo, Kim van der Heul (Helian Polymers); Bernhard Drosg, Lisa Bauer, Richard Pummer (BEST Research); Lidia Garrote, Dolores Hidalgo (CARTIF); Laurens De Brauwer (BBEPP), Filip Miketa (BIO-MI) AUTHORS EFFICIENT AND NOVEL WASTE STREAMS CO- PROCESSING TO OBTAIN BIO-BASED SOLUTIONS FOR PACKAGING AND AGRICULTURAL SECTORS Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or CBE JU. Neither the European Union nor the CBE JU can be held responsible for them.


Holocene sea level change drives different fates of two Asian horseshoe crab species Qian TANG1, Prashant SHINGATE2, Yusli WARDIATNO3, Akbar JOHN4, Boon Hui TAY2, Laura-Marie YAP5, Jasmin LIM5, Hor Yee TONG6, Karenne TUN6, Byrappa VENKATESH2, Frank RHEINDT1 1National University of Singapore, Singapore; 2Institute of Molecular and Cell Biology, Singapore; 3Institute Pertanian Bogor, Indonesia; 4International Islamic University Malaysia, Malaysia; 5Republic Polytechnic, Singapore; 6National Parks Board, Singapore Overlapping distribution range but different habitat preference Different genetic diversity as evolutionary response The coastal horseshoe crab Tachypleus gigas Study area Bintan, Indonesia Changi Beach, Singapore Preferred habitats: Mangroves, mudflats Preferred habitats: Sandy beaches The mangrove horseshoe crab Carcinoscorpius rotundicauda -0.1 0 0.1 Correlation coefficient Spatial autocorrelation analysis (GenAlEx3) within 200km: CR disperses within 35km TG disperses beyond study area PCA plot: Spatial-genetic correlation in CR Panmixia in TG ADMIXTURE4 bar plots: Subdivision along the SS in CR F coefficient: Relatively low genetic diversity in CR, especially ones at south of SS Effective population size (LinkNe5) over Holocene indicates: Sea level rise and maintain at high level disconnection among habitats CR decline Rapid sea level rise coastal area increase TG increase Sea level maintain rapid mangrove formation in coastal area TG decline Conclusions Capability of population genomic analyses at small spatio-temporal scale may redirect conservation measures. Dispersal capability and habitat preference determine species’ evolutionary response to climate change. Further decline in CR with impending sea level rise, whereas TG may increase but subject to habitat dynamics and human disturbance. Methods ~300 individuals across the Singapore Strait (SS) Hundreds of thousand genomic SNPs using double-digest RADseq Dispersal capability was examined using spatial autocorrelation and resistance mapping. Genetic diversity was examined by calculating heterozygosity and effective population size CR hereafter TG hereafter 35km Upper and lower 95% confidence limits of null spatial structure models are illustrated with red dash lines. Mapping of resistance to dispersal (DResD2) indicates depth- limited dispersal of CR No significant resistance to dispersal of TG (data not displayed) References 1. Sekiguchi (1988). Biology of horseshoe crabs. 2. Keis et al. (2013). Journal of Biogeography 40, 915-927. 3. Smouse & Peakall (1999). Heredity 82, 561-573. 4. Giri et al. (2011). Global Ecology and Biogeography 20, 154-159. 5. Hollenbeck et al. (2016). Heredity 117, 207-216. 6. Bird et al. (2010). Geology 38, 803-806. Introduction Two of four extant horseshoe crab species, widely distributed across Southeast Asia1 Ecological & commercial values Conservation status is still under evaluation Sea level fluctuation (dashed line) and carbon isotope composition (dotted line) in the Singapore Strait during the Holocene6. Mangrove distribution4 is illustrated as blackish coastal areas. Acknowledgement This research is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its Marine Science Research and Development programme (Award No. MSRDP-P19). Field work is supported by the Ah Meng Memorial Conservation Fund. CR CR CR TG TG TG Both Different dispersal capability


SFA & IRD - 40 years of research partnerships J. Lebranchu, C. Violette, L. Dagorn, P. Guillotreau (IRD/MARBEC) I. Context IRD’s principal mission is to generate science centred on the intertropical and Mediterranean zone and founded on equitable scientiﬁc partnership with the higher education and research commu- nities (ESR) of the countries and regions concerned. This mission has a dual purpose: • Contributing to advances in scientiﬁc knowledge in matters of sustainable development • Helping to give development policies a better grounding in science. IRD is present in Seychelles since 1980 (Port of Victo- ria in 1982 in front of the three of four French purse seiner). IRD has structured his research around SDG imple- mentation and Seychelles priorities, especially on preserving biodiversity and sustainable management of ocean resources. IRD has been working on diﬀerent domains: - the history of Seychelles (published in 1983), - a botanical inventory of the Seychelles' ﬂora in the 1980s and a book published in 2014 - but IRD has mainly worked on ﬁsheries and their impacts in collaboration with SFA (i.e "The Seychelles's blue gold", 2014). An overview of some studies are presented below. II. Fisheries studies A. FADIO (2003 - 2006) - 10 partners (IRD, SFA,…) from 6 countries i. FADIO (2003 - 2006) - 10 partners (IRD, SFA,…) from 6 countries FADIO (Fish Aggregating Devices as instrumented Observatories of pelagic ecosys- tems) is a project funded by the EU with two mains goals : - Objective 1: Development of prototypes: new electronic tags and instrumented buoys to observe ﬁsh aggregations around FADS - Objective 2: Improving knowledge on on pelagic ﬁsh around FADs Three main achievements: • Contributed to the development and successfully tested the ﬁrst satellite-linked acoustic re- ceiver (listening station) that allows remote, real-time monitoring of open ocean ﬁsh implanted with sonic transmitters • Obtained ﬁrst scientiﬁc descriptions of the species that comprise the community of animals associated with drifting FADs. • Obtained ﬁrst measurements of residence times and swimming depths of tuna and other pelagic ﬁsh around drifting FADs. Estimated the orientation distance of dolphinﬁsh on FADs using an experimental approach. B. MADE (2008 - 2012) - 13 partners (IRD, SFA,…) from 8 countries ii. MADE (2008 - 2012) - 13 partners (IRD, SFA,…) from 8 countries MADE (Mitigating ADverse Ecological impacts of open ocean ﬁsheries) aims at proposing mea- sures: • To reduce by-catch of sharks and juvenile swordﬁsh by pelagic longliners. • To reduce by-catch of sharks and turtles, and juvenile tunas by tuna purse seiners. • To assess the eﬀects of FADs on ﬁsh ecology (to assess how much the release of FADs modi- ﬁes the habitat and aﬀects the ecology of ﬁsh). The project follows a multidisciplinary and integrated approach to achieve its objectives: • Behavioural studies, electronic tags (pop-up archival and acoustic tags) on sharks, juvenile swordﬁsh and tuna. • Biological studies, trophodynamism, growth of sharks. • Socio-economical studies, economic eﬃciency indicators.  FOCUS: Results to reduce the shark mortality • Two independent methods have shown the extent of the issue of entanglement of sharks in nets of FADs in the Indian Ocean ==> future design of FADs should not have any netting • Guide of good practices to reduce the mortality of sharks and rays III. Data management for pelagic fisheries (from 1984) During the 1980s and 1990s, IRD and SFA scientists have developed diﬀerent ﬁsheries monitoring systems in Seychelles. Since 2000, IRD and SFA have collaborated to develop a shared informa- tion system focused on large pelagic monitoring. Figure 1: Example of collected data and associated data ﬂow IV. Biology studies IRD and SFA have conducted many studies to better understand the biology and the food web of the pelagic species, like in 2014 with the EMOTION project on tuna reproductive cycle. Figure 2: Female tuna reproductive