Walker Institute for Climate System Research www.walker-institute.ac.uk Model configuration ● FAMOUS-CI is an Earth System Model based on the HadCM3 atmosphere-ocean general circulation model ● It has optional representations of the marine and land carbon cycles, along with two-way coupling to an ice- sheet model ● FAMOUS can integrate ~100 model years per day on high performance computing resources, and has also been installed on desktop machines FAMOUS-CI a fast Earth System GCM Robin S. Smith¹, Annette Osprey¹, Oli Browne¹ and Jonathan Gregory¹׳² (r.s.smith@reading.ac.uk) ¹NCAS-Climate, University of Reading, ²Hadley Centre, UK Met Office FAMOUS-CI is an Earth System model, based on HadCM3, that has been de- veloped in the UK jointly by NCAS, the Hadley Centre, Bristol University and the QUEST and RAPID programmes. It has roughly half the spatial resolution of HadCM3, but retains all the complex processes that are represented in an AOGCM. FAMOUS-CI includes some processes not modelled in HadCM3; the fully coupled carbon cycle and ice-sheet models allow it to be applied to a wide variety of climate problems. HadAM3 HadOM3 MOSES GLIMMER HadOCC TRIFFID Atmosphere: 5.0˚x7.5˚, 11 levels Ocean: 2.5˚x3.75˚, 20 levels Dynamic Vegetation Land Surface Grounded Ice Sheets NPZD biogeochemistry www.famous.ac.uk For more information on FAMOUS, please visit our website. Here you’ll find information about getting and running FAMOUS, as well as access to our mailing list, links to the different projects in the FAMOUS community and announcments of new developments. FAMOUS Climatology Climate Simulations Classifying the preindustrial climate simulated by FAMOUS into the Köppen-Geiger climate zones shows that FAMOUS does a good job of simulating both the mean climate and seasonal variability of a modern cli- mate. Accelerated transient runs through the last glacial cycle are being used to in- vestigate the influences of different forcing factors on the climate and at- mospheric CO2 further demonstrate that the climate sensitivity in FAMOUS is realistic. FAMOUS has also been coupled to the Glimmer ice-sheet model, and has been used to investigate icesheet- climate feedbacks during glacial in- ception. Main climate - A: equatorial; B: arid; C: warm temperate; D: snow; E: polar. Precipitation - W: desert; S: Steppe; f: fully humid; s: summer dry; w: winter dry; m: monsoonal. Temperature - h: hot arid; k: cold arid; a: hot summer; b: warm summer; c: cool summer; d: extremely continental; F: polar frost; T: polar tundra The relatively low spatial resolution of FAMOUS means that it has lower computational requirements that most climate GCMs. FAMOUS can simulate around 100 model years per day using 8 processors of a high performance cluster, making millennial-scale transients and ensemble runs feasible. Like HadCM3, FAMOUS-CI does not require flux adjustments to produce a stable, reasonable simulation of modern climate. The global climate sensitivity to CO2 forcing is also very similar to that of HadCM3. Developing the common “Atlantic hosing” experiment further, an ensemble run of FAMOUS has been used to investi- gate the sensitivity of the Atlantic meridi- onal overturning circulation (AMOC) to the location of an applied freshwater flux. 0.5Sv of freshwater were applied to either the east (E) or west (W) side of the basin at a given latitude, with a second group of experiments where both east and west were hosed simultaneously (A). The AMOC weakens differently dependent on the location of the hosing, with corre- sponding differences in surface tempera- ture change. These results closely mirror the model-dependent response of the AMOC in intercomparisons, suggesting that the geography of the deepwater for- mation in the models is an important dif- ference. Some local warming was also observed to result from the AMOC de- cline. In some experiments central Green- land temperatures were found to warm whilst the wider North Atlantic cools. FAMOUS runs:


RESEARCH POSTER PRESENTATION DESIGN © 2012 www.PosterPresentations.com PERCEPTION TOWARDS PREPAREDNESS FOR DISASTER MANAGEMENT AMONG COMMUNITY HEALTH NURSES Nor Marini Mohamed, Lailatul Hazzliza Musa, Fatimah Sham, Norjah Othman, Nurul Liana Roslan Emergency And Trauma Department, Hospital Kuala Lumpur. Disasters are defined as extraordinary events which occur abruptly, bringing great damage or harm, loss, and destruction to people and the environment. Nurses may have a more conflict and difficulties in disaster decision making where the victim condition need to be treated in disaster place. Nurses play a key role in hospital as a leaders and managers in the disaster operation and command center but limited data shows that the nurses experience in disaster management. INTRODUCTION OBJECTIVE A descriptive cross-sectional study was conducted in 27 government clinics in one of the states in Malaysia with a convenient sampling, 260 participants are selected. The questionnaire consisted of three sections; socio-demographic characteristics, the perception of knowledge and skill towards preparedness for disaster management rated on a Likert scale. In the effort to collect the intended data, a self-report questionnaire adapted and modified from Disaster Preparedness Evaluation Tool (DPET) was implemented (Alrazeeni, 2015). Inclusion criteria: • Nurses who are working in Community Health Clinic in JKWPKL. • Agreed to participate in this study Exclusion criteria: • Disagreed to participate in this study This study was registered under National Medical Research Register for Medical Research (NMRR-16-2626-33093) and approved by the UiTM Research Ethics Committee (600-RMI (5/1/6), Community Research Centre (CRC) Hospital Kuala Lumpur (HKL/CRC/SL/06) and Medical Research Ethics Committee (MREC); (5) KKM/NIHSEC/P17-560 METHODOLOGY RESULTS (DEMOGRAPHIC CHARACTERISTICS) REFERENCES Ahayalimudin, N. A., & Osman, N. N. S. (2016). Disaster management: Emergency nursing and medical personnel’s knowledge, attitude and practices of the East Coast region hospitals of Malaysia. Australasian Emergency Nursing Journal, 19(4), 203–209. Al Thobaity, A., Plummer, V., Innes, K., & Copnell, B. (2015). Perceptions of knowledge of disaster management among military and civilian nurses in Saudi Arabia. Australasian Emergency Nursing Journal, 18(3), 156–164 . Alrazeeni, D. (2015). Saudi EMS Students’ Perception of and Attitudes toward their Preparedness for Disaster Management, 6(35), 110–116. Diab, G. M., & Mabrouk, S. M. (2015). The effect of guidance booklet on knowledge and attitudes of nurses regarding disaster preparedness at hospitals. Journal of Nursing Education and Practice, 5(9), 17–31. Hammad, K. S., Arbon, P., Gebbie, K., & Hutton, A. (2012). Nursing in the emergency department (ED) during a disaster: A review of the current literature. Australasian Emergency Nursing Journal, 15(4), 235–244. Ismail, A., Ghazi, H. F., & Unit, C. M. (2016). Disaster Management : Identifying Knowledge of Emergency Nurses and Community Health Nurses and Its Predictors in, 16(3), 66–74 Magnaye, B., M, M. S. M. L., Ann, F. M. M., Gilbert, V. M. R., & Heather, M. J. (2011). the Role , Preparedness and Management of Nurses During Disasters. E-International Scientific Research Journal, III(4), 294 . We would like to anknowledgement and appreciate those individual that were so helpful in assisting us to reach our goal. ACKNOWLEDGEMENTS 3.43 3.23 3.74 3.47 3.66 3.44 4.04 3.42 3.6 3.52 3.51 3.55 3.86 3.76 3.65 3.42 0.87 0.9 0.7 0.87 0.73 0.78 0.71 0.8 0.71 0.65 0.67 0.7 0.67 0.67 0.69 0.76 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8 Q9 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Figure 5 : The Perception of Knowledge Towards Preparedness for Disaster Management S2 MEAN S2 SD 3.7 3.32 3.06 3.89 3.48 3.68 3.8 3.78 3.74 3.73 3.79 3.26 3.93 3.7 3.78 3.88 3.48 3.12 3.47 3.65 0.69 0.77 0.92 0.69 0.67 0.7 0.64 0.65 0.65 0.7 0.61 0.71 0.58 0.69 0.62 0.61 0.85 0.81 0.68 0.64 0 0.5 1 1.5 2 2.5


TÍTULO: Rompiendo el ciclo: Abordaje integral en la recuperación de trastornos disociativos y dependencia emocional AUTORES: Patricia Gil Delgado1, Sara Mayo González2, Antonia María Nogales Raedo3, Patricia Menéndez Trillo4, Manuela María Rodríguez Rincón5, Andrea Blanco Pericacho6, Laura Andrea Orozco Quiroz7, Miguel Andía Díez8. FILIACIÓN: 1: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 2: Psiquiatra, Médico Adjunto Especialista en Hospital Fuente Bermeja. Complejo Asistencial Universitario de Burgos. 3: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 4: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 5: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 6: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 7: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 8: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. INTRODUCCIÓN Y OBJETIVOS: Los trastornos disociativos y de conversión, frecuentemente asociados a conductas autolesivas y crisis emocionales, pueden generar disfunción progresiva en diversas áreas de la vida del paciente. El manejo terapéutico integral, con enfoque multidisciplinario, es esencial para lograr la estabilización psicopatológica y promover la autonomía. Revisamos, a propósito de un caso, la importancia del abordaje integral en un dispositivo de rehabilitación como medio para la recuperación.


r.rafia@sheffield.ac.uk Exploratory psychometric analysis of the EQ-5D in a Myelofibrosis population Rachid Rafia, Clara Mukuria, ScHARR, University of Sheffield www.facebook.com/scharrsheffield School Of Health And Related Research INTRODUCTION The EQ-5D is a generic preference-based measure of health-related quality of life (HRQoL) applicable to a wide range of health conditions and treatments.1 Myelofibrosis (MF) is a rare but serious bone-marrow cancer in which the proliferation of an abnormal type of bone marrow stem cell results in fibrosis, or the replacement of the marrow with collagenous connective tissue fibres. Massive spleen enlargement is a consequence of the resulting extra-medullary haematopoiesis and can cause symptoms (typically abdominal pain, early satiety and difficulty in breathing); and can lead to complications such as portal hypertension, splenic infarction and vascular events. Patients commonly have symptoms such as fever, night sweats, and weight loss. There is no evidence about the appropriateness of the EQ-5D in MF; thus, this study aimed to provide psychometric evidence of its appropriateness. • This exploratory analysis suggests that the EQ-5D preference based and health dimensions had poor association with key symptoms in MF, except for the ‘pain/discomfort’ and ‘anxiety/depression’ health dimensions in some respect. • Although the EQ-5D captured some changes, these changes were much smaller than when assessed using the MF-SAF. • This exploratory analysis suggests that the EQ-5D measures’ ability to capture the effect of key symptoms in MF is limited to pain rather than the specific MF symptoms such as night sweat, itchiness. • However, results of this analysis need to be interpreted with caution due to the small number of patients and the potentially non-representative nature of the sample. METHODS The psychometric performance of the EQ-5D was assessed relative to that of a condition-specific measure, the modified MF Symptom Assessment Form (MF-SAF) version 2.0 using data from the ROBUST UK study. The ROBUST UK2 study collected data on both EQ-5D (5 levels) and modified MF-SAF v2.0 in a small sample of UK patients (n=48) with MF, post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia myelofibrosis (PET-MF) with repeated measurement over 48 weeks (baseline, week 4, 12, 24 and 48 weeks). • The EQ-5D (5 levels) classification consists of five dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), each with five levels of response (no problems, slight problems, moderate problems, severe problems, and extreme problems). A single summary score is generated and range from 1 to -0.594 with 1 representing full health and 0 for dead. • The MF-SAF v2.03 has seven symptoms (abdominal discomfort, pain under left ribs, early satiety, night sweats, itching, bone or muscle pain and inactivity) each scored from 0 (absent) to 10 (worst imaginable). A total symptom score (TSS) is generated from the first 6 symptoms. In order for the EQ-5D to be appropriate, the measure should be associated with key symptoms in MF captured by the MF-SAF, at both baseline and over time. Analysis consisted of: • Convergent validity. Convergent validity was assessed by examining how well the EQ-5D preference-based measure and health state classification dimensions were associated with the MF-SAF total score and individual symptoms. Pearson’s correlations were used for continuous variables (e.g preference based and total clinical score); whilst spearman rank correlation was used for dimensions. Correlations were analysed using data at baseline only. The following cut-offs are used to determine the strength of the association: very strong >|0.6|, strong: <|0.6 to ≥ 0.5|, moderate: <|0.5 to ≥ 0.3| and weak:< |0.3|. Given the small sample size, further assessment of convergent validity was undertaken using data from all the time points. To account for repeated measures from t


Innovative Research for a Sustainable Future www.epa.gov/research Denise MacMillan l macmillan.denise@epa.gov l 919-397-8038 Introduction 5-Day In Vivo Repeat Exposure Study Results Conclusions Non-targeted Analysis for Identification of PFAS Biotransformation Products in Rat Plasma D. K. MacMillan,1 A. Renyer,2 M. DeVito,1 M. F. Hughes,1 and L. C. Wehmas1 1: U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Durham, NC 2: Oak Ridge Institute for Science and Education, Durham, NC Per- and polyfluorinated substances (PFAS) are dispersed throughout the environment due to widespread commercial use, which leads to exposure and the potential for adverse health effects. Toxicological data are available for only a few of the nearly 10,000 currently known PFAS. The USEPA is using short term PFAS exposure studies to: o generate interim risk assessment data for priority chemicals concern to states and EPA Regions, o explore possible biotransformations in mammals, o and further understanding of the biological responses to exposure. Biotransformations of PFAS telomers have been observed in microbes and fish, but few other PFAS or species have been studied. Here we present results of non-targeted analysis (NTA) to identify potential biotransformation products (PBTPs) in plasma from rats exposed over five days to perfluoro(2,5,8-trimethyl-3,6,9-trioxadodecanoic) acid (PF-TODoA), a perfluoroether carboxylic acid oligomer of GenX, and begin to investigate biological response. PF-TODoA dose formulation o Sprague-Dawley, male/female o 8-10 weeks o n=4/sex/dose-level Day 1 2 3 4 5 6 * * * * * X * = Oral gavage. X = Rats euthanized. o Control + 8 Dose-levels o Vehicle = Water o Range: 0.3 – 335.2 mg/kg/day ~1/2 log10 spacing o Plasma (25 µL) prepared by protein precipitation with acidified acetonitrile • Chromatography: Phenomenex Kinetex XB-C18 (100 x 2.1 mm) • A: 95:5 H2O:MeOH and B: 95:5 MeOH:H2O, both containing 4 mM ammonium formate o NTA acquired with Sciex X500R QTOF • Negative ion electrospray ionization (-ESI) • Information Dependent Acquisition (IDA) and Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH) scanning Data processing, library searching (NIST 17, Sciex Fluorochemical, and in-house libraries), formula finding, peak picking and alignment, normalization, and statistical analysis were performed using Sciex OS 2.1.0 and MarkerView 1.3.1. Features were filtered by log fold change, p < 0.05, negative mass defect, and abundance. A screening list of PBTPs was generated using Biotransformer 3.0.1 MetFrag2 was used to generate in-silico spectra of potential candidates. Statistical Analysis NTA data from plasma of male and female rats exposed to 17 mg/kg/day PF-TODoA were normalized and analyzed by supervised principal component analysis (PCA-DA). The scores plot showed separation of the data for exposed samples from study controls. Data from male and female rats clustered apart from controls and distinct from each other. Differences in normalized responses of selected significant ions between groups are Control Male Female 0 -500 D1 Score -1000 500 D2 Score -600 0 600 PF-TODoA CASRN: 65294-16-8 DTXSID70191136 Data were screened for predicted PBTPs. Exact masses observed in MS scans suggested several predicted PBTPs were present, but only the ion of m/z 516.9542 gave an MS/MS spectrum. The fragment ions observed at m/z 350.9 and m/z 184.9 are characteristic of PF-TODoA and consistent with sequential cleavages of C3F6O. An in- silico spectrum generated for PubChem CID 13244841 (ion structure shown) with MetFrag matched all experimental fragment ions. The data suggest O-dealkylation of PF-TODoA to yield an alcohol with the formula C9HF19O3. F F F F F F F F F F F F F F F F F F F F F F F O O O O H O MS/MS of m/z 516.9542 F F F F F F F O – Predicted PBTPs The MS/MS spectrum of the in- source fragment of PF-TODoA, also known as HPFO-TeA, shows character


Evaluating hyper-resolution global hydrology by comparing spatial and temporal resolutions Jerom Aerts1 (J.P.M.Aerts@tudelft.nl), Rolf Hut1, Nick van de Giesen1, Niels Drost2, Ben van Werkhoven2, Berend Weel2, Inti Pelupessy2, Martine de Vos2, Yifat Dzigan2, Stefan Verhoeven2, Gijs van den Oord2, Ronald van Haren2, Janneke van der Zwaan2 , Maarten van Meersbergen2, Willem van Verseveld3 and Albrecht Weerts3,4 1Delft University of Technology 2Netherlands eScience Center, 3Deltares, 4Wageningen University Global hydrological models have transitioned from global scale to hyper-resolution (5 arc minutes or less). Benefits: • Greater applicability for stakeholders (e.g., comprehensive flood prediction) • Better understanding of hydrological system Challenges1,2,3,5 • Scaling issues that require explicit spatial modelling and parameterized processes • Require lateral connections between compartments of the hydrological system • Increased uncertainty from insufficient parameter data quality Guiding Question How is the hydrological model Wflow SBM impacted by changes in spatiotemporal resolutions? Project Goal Evaluate hyper-resolution global hydrology using the Wflow SBM model4 and the eWaterCycle II platform Why Wflow SBM? • Physically based distributed hydrological model • Can run with any time step • Spatial distribution within the hyper-resolution domain • No calibration required Introduction Intra-Model Comparison Setup Wflow SBM References: 1Beven and Cloke ,2012: Comment on “Hyperresolution global land surface modeling: Meeting a grand challenge for monitoring Earth's terrestrial water” by Eric F. Wood et al. 2Bierkens et al., 2015: Hyper-resolution global hydrological modelling: what is next? 3Melsen et al., 2016: HESS Opinions: The need for process-based evaluation of large-domain hyper-resolution models 4Samaniego et al., 2017: Toward seamless hydrologic predictions across spatial scales 5Wood et al., 2011 : Hyperresolution global land surface modeling: Meeting a grand challenge for monitoring Earth's terrestrial water Going Forward Analyses Input Model Runs Output Streamflow Validation (USGS) and statistics: State Comparison : Total of time series : Total of basin grid cells : Sum of coarse resolution grid cells : Sum of high resolution grid cells Next steps: • Include: soil moisture and snow pack validation, global basin, multiple global hydrological models • Perform benchmark testing • Compare the effect of different precipitation products Share your thoughts on: • Explicit spatial hydrological modelling on high spatial resolutions • Effects of higher temporal resolutions on comparison variables


Survey responses • Most responses were from Open Science Framework (OSF) supported preprint servers which allow users to link preprints to an OSF project where any output can be recorded. • One (csarven.ca) is a site used by one author for personal preprints. • None have a written policy requiring availability of research data. • The Berkeley Initiative for Transparency in the Social Sciences (BITSS), perhaps unsurprisingly, reports the highest values, along with csarven.ca. • Not all categories were appropriate for all fields and there was a great deal of variation between disciplines. • Only one response disclosed future plans to improve linking options. Submission systems and usage by authors Results for selected preprint servers. Numbers are the % of papers or authors with the given option shown on the abstract page. No number: this option is not available. The submission site for ChinaXiv could not be checked. * indicates that information entered during submission is not displayed directly on the abstract page. • Most older preprint servers (pre-2010) had fewer linking options. • Relatively low use of options from authors was found. Supplementary data files in life sciences were an exception. • No examples of externally linked data or software code were found for the preprints checked. • Humanities and social science servers offer better options for linking to author-specific data, such as websites or social media accounts. Martyn Rittman, Ph.D. Director, Preprints.org; Publishing Services Manager, MDPI AG St Alban-Anlage 66, 4052 Basel, Switzerland rittman@preprints.org, rittman@mdpi.com, @martynrittman Preprints Servers as a Hub for Early-Stage Research Outputs What can preprint servers offer authors and readers? By posting a preprint, authors have the potential to provide a single point of access to all of information relevant to the research project and explain how each part contributes. In other words, preprints can be a focal point for disparate early-stage research outcomes such as data, code, websites, and analysis plans. Linking these outputs can greatly increase transparency and reproducibility, benefiting the wider research community. We investigated the current status of preprints servers to link other outputs (or report as supplementary data), in particular: (i) Which options for linking and reporting are available in submission systems? (ii) What is displayed on preprint abstract pages? (iii) How often do users make use of available features? Information sources 1. Preprint submission systems were checked to see which linking and reporting options are available. 2. Preprints (25 or 50 for selected servers) abstract pages were checked to see if authors make use of available options. 3. Operators of preprint servers were surveyed about linking and reporting options, policies and future plans. Conclusions • Linking and reporting is integrated to some extent in most preprint servers, however linking to external sources is less common. Zenodo is an exception; OSF project linking offer a unique paradigm. • There is variation between disciplines due to the different kinds of early-stage outputs generated. Norms in the field may also be a factor. • Open science is not a primary goal of most preprint servers. If preprints are to be a hub for early-stage reporting, preprint servers need to plan better linking and reporting options and encourage authors to make use of them. What is your overall impression of how often authors use the linking options?


INTRODUÇÃO OBJETIVOS CONSIDERAÇÕES FINAIS REFERÊNCIAS MÉTODOS O conto “A terceira margem do rio” é um dos 21 contos que faz parte do livro “Primeiras estórias” publicado, em 1962, pelo escritor e médico João Guimarães Rosa. A obra é composta pelos personagens: pai, mãe, filho, irmão e irmã - que não são nomeados. A história é narrada pelo filho que, no decorrer do conto, revela os perfis psicológicos de cada membro da família, o que é importante para compreender o modo como a decisão do pai de construir uma canoa e viver isolado no meio do rio afetou a todos (ROSA, 2001). A Terceira Margem do Rio: O enfrentamento do luto na prática médica JÚLIA L. MATTOS¹, JULIANA A. NASCIMENTO E SILVA ¹, LAURA P. TAVARES¹, MATHEUS DIAS¹ , MARIA JULIA DA S. MENDES¹, MANUELA MARIA A. DE MORAIS E SILVA¹, SAMILY S. FRANÇA¹, ZAIRA NICOLLE F. PEREIRA¹ , RODRIGO RAMON F. GOMEZ² e PROCOPIO M. DOS SANTOS² O presente trabalho tem como finalidade discutir a temática dos assuntos ligados à saúde mental, bem como sua aplicação na prática médica frente a pacientes que estão enfrentando o luto familiar, a partir das reflexões presentes no conto “A Terceira Margem do Rio”. Estudo de caráter qualitativo e interpretativo baseado na análise descritiva do conto “A terceira margem do rio”, de João Guimarães Rosa. Foi realizada busca bibliográfica na base de dados Google Acadêmico, utilizando os descritores “luto familiar”, “morte”, “luto”. RESULTADOS E DISCUSSÃO seus enigmas e o fluir constante das águas que ecoam as complexidades da condição humana. Dessa forma, o isolamento do pai no meio do rio pode ser simbólico do processo de luto, onde uma pessoa enlutada se sente isolada e distante do mundo cotidiano. O rio pode representar o fluxo da vida, e a terceira margem, o espaço entre a vida e a morte. A ausência de uma explicação clara por parte do pai também pode refletir a complexidade e a falta de compreensão muitas vezes associadas ao luto (BUHLER, 2006). Associado ao exposto, a morte está presente de forma constante no contexto de trabalho do profissional de saúde. No entanto, é de essencial importância o preparo emocional desses profissionais na vivência do processo do luto e da morte, além do conhecimento das fases desse processo e das condutas que devem apresentar, tendo em vista a morte com o paciente e a família (COSTA et al, 2005). A narrativa de "A Terceira Margem do Rio" evoca uma sensação de ambiguidade, indicando que o luto não é um processo linear ou facilmente compreensível. Assim como o rio flui, a experiência do luto também pode ser fluida e desafiadora de entendimento. O tema morte é um assunto que as pessoas estão sempre tentando evitar em razão da dificuldade de discutir as suas significações que estão relacionadas com a finitude do ser, pois, o homem tem a probabilidade de evitar temas que lhe provocam angústias e, na tentativa de não sofrer, ele nega a morte, porém não abandona o tormento de sua presença (FREUD, 2011). Ao explorar o curso misterioso do rio e a permanência peculiar do pai na canoa, o autor oferece uma reflexão poética sobre a vida, BUHLER A. As margens do devaneio: uma análise do conto “ A terceira margem do rio”, de João Guimarães Rosa. João Pessoa, v.8, n. 1, jan/jul de 2006. COSTA C., LIMA G. Luto de equipe: Revelações dos profissionais de enfermagem sobre o cuidado à criança/adolescente no processo de morte e morrer, Revista Latino-Americana de Enfermagem, Ribeirão Preto, v. 13, n. 2, mar./abr. 2005. FREUD, S. Luto e melancolia. São Paulo: Cosac Naify, 2011. ROSA, J. A Terceira Margem do Rio. In: Primeiras Estórias. Rio de Janeiro: Nova Fronteira, 2001. Área temática: Reflexão de perda e luto 1 - Acadêmicos do 1º semestre de medicina do UNIEURO. 2 - Professores de Humanidades médicas do UNIEURO. João Guimarães Rosa - A Terceira Margem do Rio


Expedition 360: SWIR Lower Crust and Moho A. Sanfilippo & R. Tribuzio Dipartimento Scienze Terra e Ambiente, Università di Pavia, Via Ferrata 1, 27100, Pavia, Italy The project “SloMo, The nature of the lower crust and Moho at slower spreading ridges” is a multi- expedition project aimed at drilling the Mohorovičić seismic discontinuity to verify the hypothesis that the Moho corresponds to an ‘alteration front’ 2. IODP Expedition 360 3. Post-cruise meeting (Sicily, Italy) The post-cruise meeting was yield in Siracusa (May 14-17, 2017) partly supported by IODP-Italia where 40 participants preliminary results of post cruise studies and set up long standng colleborations 4. Magmatic processes at the accretion of the lower crust 5. Water-magma interaction Petrological data were combined with in-situ isotopes to discover to what extent magma interacts with and seawater during the cooling and exhumation of this lower crustal sequence 5. Peer-reviewed publications • Ferrando C., Tribuzio R., Lissenberg C.J., France L., MacLeod C.J., Basch V., Villeneuve J., Deloule E., Sanfilippo A. (2022) Brown Amphibole as Tracer of Tectono-Magmatic Evolution of the Atlantis Bank Oceanic Core Complex (IODP Hole U1473A). Journal of Petrology 63 1-27 • Ferrando C., France L., Basch V., Sanfilippo A., Tribuzio R., Boulanger M. (2021) Grain Size Variations Record Segregation of Residual Melts in Slow-Spreading Oceanic Crust (Atlantis Bank, 57°E Southwest Indian Ridge). Journal of Geophysical Research: Solid Earth 126 e2020JB020997 • Boulanger, M; France, L; Ferrando, C; Ildefonse, Benoit; Ghosh, B; Sanfilippo, A; Liu, C‐Z; Morishita, T; Koepke, J; Bruguier, O; (2021). Magma‐Mush Interactions in the Lower Oceanic Crust: Insights From Atlantis Bank Layered Series (Southwest Indian Ridge). Journal of Geophysical Research: Solid Earth, 126, 9, e2021JB022331. • Ferrando, C; Basch. V, Ildefonse. B, Deans, J., Sanfilippo, A; Barou, F., France, L. (2021). Role of compaction in melt extraction and accumulation at a slow spreading center: Microstructures of olivine gabbros from the Atlantis Bank (IODP Hole U1473A, SWIR)",Tectonophysics,815,,229001 • Sanfilippo A., MacLeod C.J., Tribuzio R., Lissenberg C.J., Zanetti A. (2020) Early-Stage Melt-Rock Reaction in a Cooling Crystal Mush Beneath a Slow-Spreading Mid-Ocean Ridge (IODP Hole U1473A, Atlantis Bank, Southwest Indian Ridge). Frontiers in Earth Science 8 579138 • Nozaka T., Akitoua T., Abe N., Tribuzio R. (2019) Biotite in olivine gabbros from Atlantis Bank: Evidence for amphibolite-facies metasomatic alteration of the lower oceanic crust. Lithos 348-349 105176 • Nguyen D., Morishita T., Soda Y., Tamura A., Ghosh B., Harigane Y., France L., Liu CZ, Natland J., Sanfilippo A., MacLeod C., Blum P., Dick H.J.B. (2018). Occurrence of Felsic Rocks in Oceanic Gabbros from IODP Hole U1473A: Implications for Evolved Melt Migration in the Lower Oceanic Crust. Minerals, 8: 583; https://doi.org/10.3390/min8120583 • Dick, H.J.B., MacLeod, C.J., Blum, P., Abe, N., Blackman, D.K., Bowles, J.A., Cheadle, M.J., Cho, K., Ciążela, J., Deans, J.R., Edgcomb, V.P., Ferrando, C., France, L., Ghosh, B., Ildefonse, B., John, B., Kendrick, M.A., Koepke, J.H., Leong, J.A.M., Liu, C., Ma, Q., Morishita, T., Morris, A., Natland, J.H., Nozaka, T., Pluemper, O., Sanfilippo, A., Sylvan, J.B., Tivey, M.A., Tribuzio, R. & Viegas, G., (2019). Dynamic accretion beneath a slow spreading ridge segment: IODP Hole U1473A and the Atlantis Bank Oceanic Core Complex. J. Geophys. Res. Solid Earth. 1. SloMo Project – Leg 1 Microtexture and mineral chemistry showed evidence for process of magma extraction within the studied gabbros From December 2015 to January 2016 the IODP Expedition 360 drilled 800 mbsf of basement rocks at the Atlantis Bank Oceanic Core Complex, Southwest Indian ridge. Hole U1473A respresents thrid longest perforation in the lower oceanic crust, the first in a single leg expedition. Atlantis Bank OCC Petrological studies and detailed


I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 Towards the Design of Robotic Drivers for Full-Scale Self-Driving Racing Cars Danilo Caporale∗,†, Alessandro Settimi†, Federico Massa†, Luca Bonamini‡, Manuel G. Catalano‡‡, Antonio Bicchi†,‡,‡‡ and Lucia Pallottino†,‡ Abstract— We report on the development of a planning and control framework for an electric full scale autonomous racing car. We describe the whole control system architecture including the mapping and localization methods employed. We also report on novel experimental results obtained within the Roborace Localization challenge, whose ﬁrst edition took place in Zala Zone1 track in August 2019, related to an informed version of Adaptive Monte Carlo Localization developed for the racing scenario. I. AUTONOMOUS RACING SYSTEMS Challenges are one of the main drives of robotics devel- opment, that call for integration of recent research results in real world applications. In the particular case of self-driving cars, the DARPA Grand Challenge and Urban Challenge have pushed the robotics community to develop autonomous cars meant to drive in unstructured or urban environments. Following the encouraging results of these challenges, car producers have started developing self-driving technologies, which are foreseen to become a disruptive reality in the next decade and possibly the ﬁrst widespread Artiﬁcial Intelligence (AI) applications in robotics. From deploying single vehicles to the consumer market to ﬂeets of shared vehicles to be used as a service, there is a strong interest in the development of level 4 and 5 autonomous behaviors for these cars. Of course, to achieve that, human safety is one of the main concerns. In fact, one of the expected results of the mass adoption of these systems is a sensible reduction of the rate of accidents, especially those due to the errors of human drivers. Despite this being a reasonable outcome, at the moment of writing this paper it is not yet clear where we stand with respect to this goal, and extensive testing would be necessary to conﬁrm that this goal is within reach. In this work, we focus on the particular scenario of a racing track environment, which allows driverless vehicles testing in extreme conditions (high accelerations that trigger the nonlinear behavior of vehicles) without jeopardizing human safety. The interest in this application is justiﬁed by the recent creation of racing challenges for full scale (Roborace2), middle scale (Formula SAE3), and small scale ∗Corresponding author: d.caporale@centropiaggio.unipi.it † Centro di Ricerca E. Piaggio - Universit`a di Pisa - Pisa, Italy ‡ Universit`a di Pisa - Pisa, Italy ‡‡ Istituto Italiano di Tecnologia - Genova, Italy 1https://zalazone.hu/en/ 2https://roborace.com/ 3https://www.fsaeonline.com/ Fig. 1. Roborace DevBot during the ﬁrst Localisation Challenge - Zala Zone (Hungary) 2019. (F1Tenth4) vehicles. Autonomous racing capabilities for non- electric vehicles have been demonstrated but big challenges remain open in improving the self-driving capabilities of full scale electric racing cars. The experimental results we present were obtained on a Roborace’s DevBot, the development version of Robocar (see Fig. 1). The car can be driven either by a human pilot or by an autonomous system. The control architecture of the vehicle is hierarchical and it includes, at low-level, fast response control-loops implemented by the manufacturer, ensuring closed loop control of the actuators and raw input processing from the on-board sensors, while exposing at higher level an open platform for the implementation of user-deﬁned control strategies and perception schemes, see Fig. 2. This key feature ﬁrst enables rapid development and testing of full-stack autonomous driving control solutions, in which the designer can focus on driverless technology. It also seamlessly allow for the implementation of learning-based approaches in which the human or autonomous driver can


U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov Introduction Methods Conclusions Brett Blackwell l blackwell.brett@epa.gov l 218-529-5078 Empirical measurement of PFAS dosing within in vivo aquatic high throughput assays B. Blackwell1, E. Stacy1, K. Bush2, K. Flynn1, J. Hoang2, M. Le2, D. Villeneuve1 1USEPA Great Lakes Toxicology and Ecology Division, Duluth, MN; 2Oak Ridge Institute for Science and Education (ORISE), Duluth, MN • Understanding per- and polyfluoroalkyl substances (PFAS) toxicity is a priority of the US EPA, and high- throughput testing (HTT) has been developed as a rapid, low-cost alternative to traditional in vivo toxicity testing. • The unique physicochemical properties of PFAS preclude accurately modeling free chemical concentrations using current in vitro disposition models. • Characterizing chemical behavior and partitioning in HTT format is critical for comparison of HTT- derived points of departure with those from traditional aquatic toxicity assays. • Here, 22 individual PFAS (Table 1) were screened for toxicity to juvenile Daphnia magna (see poster 4.21.P-Th175) or Pimephales promelas (poster 2.14.P-We058) following 24 h exposure in 96 well format. • Final concentration of each PFAS in exposure media was empirically measured by LC-MS to accurately assess exposure conditions. Chemical Exposures • PFAS (Table 1) were acquired from EvoTec (South San Francisco, CA) solubilized in DMSO at a nominal concentration of 30 mM and 9.5 mM. Subsequent concentrations were made in a log dilution series from these two solutions for a total of 9 concentrations at ½ log steps. Nominal exposure concentrations ranged 0.03 – 100 μM for each PFAS. • Organisms were exposed to 8 concentrations of each chemical (plus a control) in 1mL polypropylene 96-well plates (n=5 individuals per concentration) in a total volume of 700 µL Lake Superior water spiked with working stock (concentration of DMSO<0.33%). • Working stocks were saved in 1:1 acetonitrile:media or 3:1 acetonitrile:media for chemical analysis. • Exposures were performed for 24 hours at 20 °C (D. magna) or 25°C (P. promelas) with a 16:8 light:dark cycle. Following this, media was transfered from exposure plates into a clean well plate, diluted 1:1 or 3:1 with acetonitrile, and stored at -20°C. • Three replicates per concentration were analyzed for each individual PFAS. For P. promelas, individual replicate wells from one exposure plate were measured while for D. magna, 5 replicate wells per concentration were pooled within 3 replicate exposure plates. The lowest concentration of each PFAS was not measured due to concentrations consistently below or near detection limits (n = 14-21 wells per chemical). Effluent Discharge *Contents of this poster neither constitute, nor necessarily reflect, official US EPA policy. Use or mention of trade names trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government* Chemical Verification • Chemical stocks used to prepare exposure plates and media from post-exposure plates were analyzed by LC-MS using a Vanquish LC system coupled to a TSQ Altis tandem MS. • One method based on EPA Method 1633 (method details given below) was used for quantification of most target analytes. Individual methods were developed for 6:1 FTOH, PFPB, and PFTP. • A stable mass labeled internal standard was used where possible to account for potential matrix effects and analyte loss during sample preparation. • For compounds without a matched internal standard, a stable labeled surrogate with the nearest retention time was used for quantification. Thermo Scientific Vanquish LC system • Column: StableBond C18, 2.1 x 50mm, 1.8μm • Column Temp: 40°C • Injection volume: 5 μL • Mobile phase: A = H2O+5mM ammonium acetate B = MeOH Flow rate: 0.4 mL/min • Gradient: 10% B to 55% B at 2.5 min, to 90% B at 9 min, to 100% B at 9.5 min, held for 2 min, return to 10% B. • Total


www.nanorigo.eu @EU_NANORIGO www.linkedin.com/groups/12232026 NANORIGO has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the grant agreement No. 814530 Knowledge Readiness Level (KaRL) approach for nanorisk governance and beyond MORE INFORMATION: Project Coordinator: Aarhus University, Janeck James Scott-Fordsmand (jsf@bios.au.dk) Scientific Coordinator: Environmental Assessments, Rudolf Reuther (rudolf.reuther@enas-online.com) Background Regulatory decisions require reliable data and knowledge One form of knowledge is an actionable document Actionable document is a piece of grey literature prepared from operational data of high technical quality, ready to be used for an action (dossiers, public opinions, proposal, meta-analysis, scoping reviews) Usually, actionable documents are prepared by the third party, e.g. consultancies NANORIGO solution – KaRL approach A 9-level scale in analogy to TRL (technology readiness level), the KaRL (Knowledge, Data and Information Readiness Level) allows assessment of knowledge readiness for decision making and provides guidance on how to enhance the readiness level KaRL addresses SEIN principles, circular economy A specialized nanorisk governance council (being in development, NANORIGO) could perform quality check of an actionable document KaRL guarantees traceability of knowledge before its use in decision making transparency Dmitri Ciornii1,* Damjana Drobne2,* Sara Novak2, Eva Kranjc2, Nils Bohmer3, Vasile-Dan Hodoroaba1 1Federal Institute for Materials Research and Testing (BAM), Division 6.1 Surface Analysis and Interfacial Chemistry, 12200 Berlin, Germany 2Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana, Slovenia 3Society for Chemical Engineering and Biotechnology (DECHEMA), Theodor-Heuss-Allee 25, 60486 Frankfurt am Main, Germany E-mail: Dmitri.ciornii@bam.de; Damjana.Drobne@bf.uni-lj.si Challenges in Nanorisk Governance Actionable document‘s quality is argued among stakeholders, consensus on what is reliable document is missing Public is not involved in decision making lack of trust in nanotechnology Decisions on nanorisk are not transparent Inefficient knowledge transfer/sharing, usability Sustainability and circularity are not poperly addressed by policy Fig. 1 KaRL approach in the framework of nanorisk governance Different stakeholders provide data to the specialized nanorisk governance council (NRGC). KaRL1-9 system could be used by NRGC for assessment of data and knowledge readiness. The readiness (maturity) progresses with each level (right hand-side, green boxes): the data, information and knowledge become more reliable and trustful, traceable and ready for the regulatory use.


DISSEMINATING OPEN SCIENCE: from librarians’ watch to in-house expertise / Originality and strengths The group’s success is based on the diverse background of the participants and the sharing of various skills around open science! A deep knowledge of the needs of the French librarians and communication skills are the key factors of the group • Working and communicating widely to raise awareness on emerging themes and trends • Making surveys and analyzing outputs • Organizing free webinars or workshops, and providing handy reference material dedicated to the community • Delivering concise and accurate information to Higher Education and Research institutions Sharing intelligence to foster negotiations: • Expertise on the French Digital Republic bill, on Text and Data Mining, on Plan S. • The group is working on identifying the terms of each current and future global agreements and trying to elaborate evolving scenarios to determine what would be a successful negotiation. • Given the success of the NegOA group, there are some ongoing reflections about the way to involve data and legal specialists into negotiations / Couperin missions Couperin is a consortium for electronic resources negotiations in France. Couperin missions To build and develop a national network of skills and exchange in the field of electronic resources. To evaluate, negotiate and organize the purchase of digital documentary contents at the best price for its members. Couperin aims to : • Help clarify and develop contractual relations with publishers • Contribute to the development of a French-language digital content offering • Promote access to electronic resources for people with disabilities • Produce and support studies on the use of electronic resources. • Promote national, European and international cooperation in the field of Scientific and Technical Information. • Promote open science Consortium unifié des établissements universitaires et de recherche pour l'accès aux publications numériques CONTACT Jacqueline Gillet jacqueline.gillet@inria.fr Cédric Mercier cedric.mercier@universite-paris-saclay.fr https://gtso.couperin.org / How the group works The group supports the open science community in France. Today OSWG is organized into 4 subgroups: • Research Data Subgroup Its goal is to propose an operational approach to research data management in the context of open science. • Open Access Negotiations Subgroup Its goal is to address the need for a better understanding of the open access components of the negotiations in the context of French research. • Legal SubGroup The group investigates legal issues related to open science. • Interoperability and Networks group The group is working to assess the interoperability issues between the different open science databases, tools and services. digital identity academic visibility databases repositories read and publish agreements advices for negotiators monitor international practice sharing best practices communicate plan s – rss – tdm surveys community resources for researchers tools for research support services training sessions


Meal Pattern and Obesity Sector for Biostatistics & Repository Data, NIH, MOH among Adolescents in urban area 18.5% 11.3% P-81 ACKNOWLEDGEMENT ACKNOWLEDGEMENT 85% OBESITY CHARACTERICTICS Referrence: Abarca-Gómez L, Abdeen Z.A, Hamid Z.A, Abu-Rmeileh N.M, Acosta-Cazares B, Acuin C, Adams R.J, Aekplakorn W, Afsana K, Aguilar-Salinas C.A. (2017). Worldwide trends in body- mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet, 390: 2627–2642. Appannah G, Pot G.K, Oddy W.H, Jebb S.A, Ambrosini G.L.(2017). Determinants of a dietary pattern linked with greater metabolic risk and its tracking during adolescence. J. Hum. Nutr. Diet. 31, 218–227. Institute for Public Health Institute for Public Health (IPH), National Institutes of Health, Ministry of Health Malaysia. 2018. National Health and Morbidity Survey (NHMS) 2017: Adolescents Health Survey 2017. Yunsheng Ma, Elizabeth R. Bertone,Edward J. Stanek III, et al. Association between eating patterns and obesity in free-living US adult population. American Journal of Epidemiology 2003; Vol. 158, No.1. Bellisle F, McDevitt R, Prentice A. Meal frequency and energy balance. Br J Nutr 1997;77 (supply 1):S57-70.surement studies in 128.9 million children, adolescents, and adults. Lancet, 390: 2627–2642. 1. 2. 3. 4. 5. INTRODUCTION INTRODUCTION Obesity was found to be higher among males and Bumiputera Sarawak. DISCUSSION AND CONCLUSION DISCUSSION AND CONCLUSION This study showed that the prevalence of obesity among Malaysian urban adolescents was quite high with estimating of 1 in every 7 adolescents found to become obese. The study has limitations since it concentrated on the relationship between obesity and food intake effects without taking into account other possible causes. Awareness programmes and activities on obesity and healthy meal pattern need to be improved especially among primary and secondary students. OBESE 15% The prevalence of obesity may have reached a plateau in some developed countries and become more complex and intractable in many developing countries. Poor diet patterns are found to be prospectively associated with an increased risk of adolescent obesity. The aim of this study is to determine the association of having frequent meals towards obesity among Malaysian school-going adolescents in urban areas. 1 2 METHODOLOGY METHODOLOGY This study used the data from National Health Morbidity Survey (NHMS) 2017, a nationwide cross- sectional survey that implemented a two-stage stratified random sampling design. Total of 23,463 adolescent age between 10 to 17 years old from the urban area were involved. Complex samples logistic regression analyses were then performed to estimate the odds of being obese according to the meal type using the SPSS software version 25. Meal patterns are used to describe individuals' eating patterns at a different level of a meal including of breakfast, lunch, dinner, or a smaller-sized meal like supper or snack in a week. 2,103 with male adolescents 187,471 were obese estimated population 1,393 adolescents with f e m a l e 109,990 were obese estimated population Classification table 85%, Nagelkerke R square: 3.3% Others RESULT RESULT Farahdila H, Anita A, Zamtira S, Rozita MY, Azahadi O NMMR-16-698-30042 The author would like to thank the Director of Health Malaysia for permission to present this poster. Appreciation is also dedicated to all individuals who contributed to the success of this study. NOT OBESE 297,462 estimated population of adolescents were o b e s e in urban Malaysia 15% 85% male unadjusted odds ratio 95% ci p-value multivariat adjusted 1.776 1.000 0.942 0.948 0.933 0.963 1.851 1.000 0.973 0.986 0.944 0.949 1.578-1.998 reference p<0.001 0.016 0.344 p<0.001 p<0.001 female breakfast lunch dinner supper 0.942-0.981 0.923-0.974 0.908-0.959 0.943-0.983 p<0.001 odds ratio 95% ci p-value 0.952-0.995 0.957


FSC-A SSC-A 0 65536 131072 196608 26214 101 102 103 104 105 Propidium Iodide: Permeabilized Cells Propidium Iodide: Non-permeabilized Cells Abstract Abstract Separation of Epithelial Cell Mixtures Using Fluorescently Labeled Antibodies and Flow Cytometry Cristina E. Stanciu, BS*, Ye Jin Kwon, MS, Sarah R. Ingram, BS, Eduardo E. Bustamante, BS, Jamie Sturgill, PhD, Sarah J. Seashols, PhD, Tracey Dawson Cruz, PhD, Christopher J. Ehrhardt, PhD, Virginia Commonwealth University, Department of Forensic Science, 1015 Floyd Avenue, Rm 2015, Richmond, VA 23284 During this presentation, attendees will be introduced to a novel molecular technique that utilizes fluorescent antibody probes that target antigens within the Major Histocompatability Complex (MHC) on epithelial cell surfaces. Attendees will also learn how antibody hybridization can be coupled to flow cytometry to provide rapid separation of targeted cell populations from a forensic mixture. This research will impact the forensic science community by introducing a high throughput, nondestructive method for generating single source DNA profiles corresponding to each contributor of an epithelial cell mixture. The technique can assist forensic caseworking units by providing an alternative to complex profile interpretation procedures, thereby reducing analytical bottlenecks and loss of evidence. Previous research has shown the application of flow cytometry coupled to antibody probes targeting the Human Leukocyte Antigen system for selectively isolating individual cell populations from a blood mixture to generate single source STR profiles. Our goal with this research was to test this technique against various types of epithelial cell mixtures for resolving individual contributor profiles. Due to its efficacy in earlier studies, we chose an antibody probe complementary to the A*02 allele for all experiments. Hybridization experiments were conducted on both buccal cell mixtures and contact epithelial cell mixtures. Results from buccal cell mixture hybridization showed that this cell type has intrinsically high levels of fluorescence which can interfere with the signal originating from specific probe-antigen interactions on the cell surface. However, detailed statistical analysis of fluorescence histograms did indicate greater shifts in cell fluorescence when donor cell populations were either heterozygous or homozygous for the A02 allele. This suggests that separation of labeled cell populations is still possible even if antibody reactivity is not strictly a function of HLA genotype. In the second experiment, hybridization of the A02 probe was tested against contact epithelial cells. Cells were sampled from the stratum corneum of the epidermal layer from 4 different individuals representing a range of HLA types. Hybridization results showed little to no interaction with the cell surface across all donors tested. This suggests that HLA antibody probes have the potential to resolve complex mixtures containing different sources of epithelial cells (buccal cells from skin) which may aid in the analysis of certain types of forensic cases. Other signatures of epithelial cells have been analyzed by flow cytometry, leading to an enrichment of DNA from one contributor in a mixture. Intrinsic fluorescence intensities of keratinized cells from different donors have been observed in the far red wavelengths, which suggests that environmental factors may affect the autofluorescence of their cells. Shedder status may facilitate mixture separation through area side-scatter and forward-scatter profiles. Corneocytes on the surface of our skin may be more abundant as fragments or as large intact cells, depending on the individual, and their membrane permeability status along with different DNA content may provide new avenues for discriminating contributors in a mixture. Key words: epithelial, mixture, FACS Flow Cytometry: Buccal and Contact Epithelial Cells Flow Cytometry: Buccal and Contact Epithelial


Information Classification: General Research Citations Building Trust in Wikipedia Kath Burton Survey Design What did the survey reveal about trust in Wikipedia citations? Survey Responses • • • • • • • • • • • • • • • • • Objective Introduction Response analysis • 46% • 28% • 6.7/10 • 4.4%


Two exceptions: (a) Lottery Tickets (LTs) and, (b) Dynamic Sparse Training (DST). Q: What makes DST and LTs the exceptions? We observe poor gradient flow at initialization and during training - even for LTs! Gradient Flow in Sparse Neural Networks and How Lottery Tickets Win Utku Evci1, Yani Ioannou2, Cem Keskin3, Yann Dauphin1 1Google, 2University of Calgary, 3Meta 1. Motivation: Unstructured Sparse NN Training results in poor generalization 2. Poor Gradient Flow at Init.: We propose a Sparsity-aware Initialization 3. Poor Gradient Flow during Training: DST Improves gradient flow during training 4. Lottery Tickets Relearn the Pruning Solution: LTs are easier to train because they initialized within the same solution basin as the pruned solution, and effectively relearn the pruning solution dense initialization dense solution good pruned solution good pruning mask only (scratch) sparse initialization LT or scratch training ϴt=T ϴt=0 training ϴ0<t≪ T early snapshot LT initialization (revised) LT initialization (original) sparse solution LT: good, scratch: bad MDS Embedding Sparse NN training use dense initialization, but sparse NN have different fan-in/fan-out! Our sparsity-aware initialization accounts for fan-in/fan-out of unstructured sparse neurons giving: (a) better gradient flow at init. and, (b) better generalization a weight mask _ 1 _ _ 2 2 fan in 0 a 0 0 b c b c We investigate LT solns to pruned solns: (a) LTs start close and move towards to the pruning solution. (b) LT solutions are in the same basin as the pruning solutions. (c) high function similarity and poor LT ensemble performance


For further information visit: http://wedc-knowledge.lboro.ac.uk/ There will be times when it is not feasible to dig a deep pit. For example, when: • the water table is very close to the surface; • it is very difficult to dig more than 1.0 to 1.5 metres below water in a confined space; • there is hard rock close to the surface; and • the ground in which the pit is to be dug is so soft that it keeps collapsing before an adequate depth can be reached. In such circumstances it is often easier to dig two shallow pits than one deep one. The pits are usually connected to the toilet by short pipes that converge at an inspection chamber. The inspection chamber must have an air-tight cover to prevent flies and mosquitoes entering and odours escaping. Twin-pit latrines 1 Using a twin-pit latrine • Before use, the inspection chamber is opened and the outlet to one of the pits is blocked with a large stone or a block of wood. This forces all wastes from the toilet to pass into only one of the pits. • The first pit fills after about two years. The inspection chamber is reopened and the stone or wooden block is moved to cover the pipe leading to the full pit. The inspection chamber is closed again and the latrine returned to use. Wastes will now collect in the second pit. • When the second pit is full, the contents of the first pit will have been standing for at least two years and virtually all of the pathogenic organisms will have died. At this point, it will be safe to remove the pit cover slab and dig out the contents. By this time the pit contents will have broken down to leave an odourless material which can be safely spread on the ground to help improve the quality of soil. • After the first pit has been emptied the cover is replaced, the blockage in the inspection chamber is moved again and the first pit reused. • From then on, a pit is emptied every two years. Side view Handles for both pits and the chamber access cover © WEDC Top view (Distance between pits (a) = width of one pit) (a) (a) (a) Pit 1 (in use) Pit 2 (not in use) Inspection chamber with stone or block of wood for blocking secondary pipe © WEDC For additional information about twin pits refer to Poster 14. Developing knowledge and capacity in water and sanitation POSTER 13


Methods This study is using a multiphase mixed methods design. This means that both qualitative methods (such as interviews) and quantitative methods (such as statistical analysis) are being used. The results of the earlier phases will feed into the later phases. Rationale Students frequently find physics difficult and teachers often do not know why. The teacher can give the student all the information they think the student needs and the student still does not understand it. This research project is investigating how students develop an understanding of these particularly tricky physics topics with the aim of producing some useful teaching resources. Students’ ideas about science are complex and interconnected. They often have their own incorrect theories about the way the world works (called ‘alternative conceptions’). A single alternative conception can lead to multiple misconceptions: Findings So Far The interviews with physics teachers for Phase One have been completed and analysed. The tricky physics topics identified for further research in Phase Two are: Electricity, Forces and Radioactivity. Electricity and forces have often been identified by past research as tricky topics for students to learn, but there has not currently been much research into students’ understanding of radioactivity, so this is an interesting finding. Even though teachers from two different schools were interviewed, their students have similar issues and the same misconceptions (such as confusing the nucleus or a plant/animal cell with the nucleus of an atom and thinking an atom has DNA). (Mis)Understanding Physics Katherine Langford, Psychology, FASS What Makes Physics Difficult? Research, including this study, indicates that students often find physics difficult because: Physics concepts (e.g. forces) are often abstract so you cannot see or touch them. Our everyday experiences sometimes conflict with scientific theory. Students frequently struggle with maths, such as equations. Students pick up bad science from everyday sources such as movies or even past teaching. For example, most of us only experience gravity on Earth, so students sometimes think that gravity on other planets must be exactly the same. In fact, gravity is stronger on bigger planets and weaker on smaller ones. Frankenstein Thinking Motivated ReasoningOnce a student has a misconception, it’s really difficult to get rid of it because ofmotivated reasoning.This is when people apply their reasoning in a one-sided manner that supports and rationalises their beliefs while rejecting information that doesn’t fit in with their beliefs.Intelligence is influenced by more than DNA.DNAMotivationHealthEducationUpbringingNutritionThere seems to be a link between students enjoying a subject and them being motivated to learn about it.Note: Having fun is therefore important!!! Lots of people think this character is called Frankenstein, but it’s actually Frankenstein’s monster. A lot of research just lists students’ misconceptions, which isn’t enough. We need to look for the causes of misconceptions. Teachers and researchers often assumme that misconceptions like this are easy to fix by simply giving students the correct information, but it often doesn’t work like this with science as students simply reject what their teachers tell them. Dr Frankenstein is the one who created the monster. Refusing to believe in climate change despite the scientific evidence is a good example of motivated reasoning. Scientists are also more likely to accept results which fit in with their own beliefs.EXAMPLES How do Secondary School Students Develop an Understanding of Tricky Physics Topics?


Xiaomin Ye1,2*, Jianqiang Liu1,2, Mingsen Lin1,2 , Bin Zou1,2, Jing Ding1,2 , Qingjun Song1,2, Yue Teng1,2 1National Satellite Ocean Application Service, Ministry of Natural Resources, Beijing, China; 2Key Laboratory of Space Ocean Remote Sensing and Application, MNR, Beijing, China *E-mail: yexiaomin2011@foxmail.com；ORCID: 0000-0003-1044-0125 Introduction of HY-1C and HY-1D satellites The Chinese Haiyang-1C (HY-1C) and Haiyang-1D (HY-1D) satellites, the follow-on mission to the HY-1A and HY- 1B satellites, was launched in September 2018 and June 2020, respectively. This satellites are both equipped with the COCTS and a coastal zone imager (CZI), as well as an ultraviolet imager (UVI), a satellite calibration spectrometer (SCS) and a satellite-based automatic identification system (AIS) receiver. The orbit altitude and tilting angle are 782 km and 98.5 degrees, respectively. The overpass times are10:30 AM±30 min local time at the descending node for HY-1C and are 1:30 PM±30 min local time at the ascending node for HY-1D, respectively. The joint observations of HY-1C and HY-1D increase the observation time and improve the global coverage. The COCTS instruments on the two satellites can detect the global ocean and land four times every day and provide daily ocean color and daytime and nighttime SST data. The COCTS is a moderate-resolution imaging scanner with a nadir spatial resolution of 1.1 km and a viewing swath width of more than 2900 km. The satellite measures signals in 8 visible and near-infrared (VNIR) bands and 2 thermal infrared (TIR) bands (10.3~11.3μm，11.5~12.5μm). Evaluation of sea surface temperatures derived from the HY-1C and HY-1D satellites Global SST have been detecting by the COCTS instruments since September 2018. The BTs (Level-1 data) and SST products (Level-2 and Level-3 data) of SST can be distributed to public for free. Examples of data products are shown in Fig.1 to Fig.4. Level-3 SST data are the gridded products with a grid resolution of 4 km and 9 km(see Fig.4). Fig.1 Global quasi true-color image from COCTS on HY-1C (acquired on October 8, 2019) A nonlinear SST algorithm (NLSST) is applied to derive SSTs from the brightness temperatures (BTs) of the two COCTS thermal infrared bands at 10.8 and 12.0 μm. The SST retrieval results from the multichannel SST algorithm (MCSST) are used as the first guess for the input of the NLSST algorithm. The coefficients of both the MCSST and NLSST algorithms are regressed from the matchup datasets of the COCTS BT observations and the measurements from the in situ Quality Monitor system (iQuam). The algorithm coefficients of HY-1C and HY-1D can be found in Ye et al (2021) and Ye et al (2022). ___________________________________ Acknowledgements The authors would like to thank the NASA Goddard Space Flight Center, Ocean Ecology Laboratory, and Ocean Biology Processing Group (OBPG) for providing access to the MODIS and VIIRS SST data, as well as the Center for STAR and NOAA National Environmental Satellite, Data, and Information Service (NESDIS) for providing access to the in situ iQuam data for validation in our study. References [1] X. Ye,, J. Liu, M. Lin, J. Ding, B. Zou，Q. Song, and Y. Teng, "Evaluation of Sea Surface Temperatures Derived From the HY-1D Satellite," in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, vol. 15, pp. 654-665, 2022, DOI: 10.1109/JSTARS.2021.3137230. [2] X. Ye, J. Liu, M. Lin, J. Ding, B. Zou and Q. Song, "Sea Surface Temperatures Derived From COCTS Onboard the HY-1C Satellite," in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, vol. 14, pp. 1038-1047, 2021, DOI: 10.1109/JSTARS.2020.3033317. Fig.4 (a) Daily gridded nighttime SST of HY-1C satellite on October 8, 2019 and (b) Monthly gridded daytime SST of HY-1D satellite in June 2021. Fig5. Validation results of SST from COCTS against in situ measurements from iQuam during (a) daytime and (b) nighttime in the period from Ja


Neutrino Energy Estimation Techniques in NOvA Nitish Nayak University of California, Irvine (For the NOvA Collaboration) 2. Detection Principle • Upgraded NuMI muon neutrino beam at Fermilab (700 kW design) • Longest baseline in operation (810 km), large matter effect (±30%), sensitive to mass hierarchy • Far/Near detector sited 14 mrad off-axis, narrow-band beam around oscillation maximum 1. NuMI Off-Axis νe Appearance Experiment [2]. P. Baldi, J. Bian, L. Hertel, L. Li Phys. Rev. D 99, 012011 • Tracking Calorimeter with Low-Z scintillator (mineral oil- based) • Finely segmented • Good separation • Radiation Length ~ 6 cell depths -> Good energy resolution WLS Fiber Readout at APDs CC νµ CC νe NC e−/µ−/⇡0 3. νe Energy Reconstruction • Identify EM and hadronic clusters using a context-enriched CNN [1] • Takes into account e/h detector response 5. νµ Energy Reconstruction • Muon hits grouped by a kalman tracking algorithm • Energy highly correlated with track length, resolution ~ 3% • Hadronic energy estimated from visible hadronic activity using a spline-based fit • Includes hadronic activity overlapping with muon track • Takes into account different regions of phase space in the underlying interaction model • Energy resolution ~ 26% • E(νµ) = Emuon + Ehadron with overall resolution ~ 6% 0 5 10 15 20 Reco Muon Track Length (m) 0 1 2 3 4 5 True Muon Energy (GeV) 2 − 10 1 − 10 1 NOvA Simulation Neutrino Beam 0 0.5 1 1.5 2 Visible Hadronic E (GeV) 0 1 2 3 4 5 True Neutrino E - Reco Muon E (GeV) 2 − 10 1 − 10 1 NOvA Simulation Neutrino Beam • Individual calorimetric energies are fit to true neutrino energy • E(νe) = A*EEM + B*EHAD + C*EEM 2 + D*EHAD2 • Helps to keep resolution bias flat vs true energy • Overall neutrino energy resolution ~ 11% 4. νe Energy - Further Improvements • Use images of the νe CC interaction directly and feed it into a regression based CNN • Minimal reconstruction dependence • Flattened input true neutrino energy distribution to control bias • Significantly better performance! [2] • Better control over systematic uncertainties 6. νµ Energy - Further Improvements • Tracking is more relevant for muons than calorimetry • Makes more sense to use physics- related reconstructed quantities as input • Feed track lengths, track energies etc into a LSTM-based RNN • Useful when number of inputs not known apriori • Similar unbiased training yields very promising improvements too! [1]. F. Psihas, E. Niner, M. Groh et al. Phys. Rev. D 100, 073005 A. Back, M. Groh - ML applications in NOvA (Poster) sequential output sequential input


Mass-spectrometry data analysis & web-platform development. Interplay between proteins and disease states. New tools I’m interested in:


Als Linked Open Data wird die direkte Vernetzung von frei verfügba ren Daten im Internet bezeichnet. Aufgrund der ständig wachsenden Datenmenge ergeben sich für die Wissenschaften daraus ganz neue Erkenntnismöglichkeiten. Dieses Wissensnetzwerk kämpft unter anderem mit dem Problem von nicht eindeutigen Begrifflichkeiten. Der natürliche Wortlaut ei nes Begriffs genügt datenverarbeitenden Systemen oftmals nicht, um sich dessen exakte Bedeutung zu erschließen. Eine maschinen lesbare Definition beinhaltet daher neben natürlichsprachlicher Er läuterungen auch Verknüpfungen zu anderen Datenquellen, um den korrekten Begriffskontext sicherzustellen. Labeling System ist eine Web-App, die an dieser Stelle ansetzt und mittels einer leicht bedienbaren Nutzeroberfläche das Erstellen von Begriffen und deren maschinenlesbarer Definitionen ermöglicht. Wissenschaftler*innen haben so die Möglichkeit, ihr Wissen als ”Lin ked Open Data“ zur Verfügung zu stellen und somit die Qualität der Forschungsdaten in ihrem Arbeitsgebiet zu verbessern. labeling system #Linked Data #Web-App #Usability #Publizieren im Netz #Metadaten Florian Thiery Axel Kunz Matthias Dufner Features • Leicht zu bedienender Web-Editor • Suchfunktion für Referenzthesauri wie Getty oder Wikidata • Erstellen, Definieren, Bearbeiten und Publizieren von digitalen Begriffen • Offener Zugriff auf das erstellte Wissens netz Hochschule Mainz – University of Applied Sciences – Lucy-Hillebrand-Straße 2 –55128 Mainz – mainzed.org Mainzer Zentrum für Digitalität in den Geistes- und Kulturwissenschaften


Fig.4 Botryosphaeria dothidea cultivated on MEA medium. Growth of the mycelium after 5 days (a), 10 days (b) and 1 month (c) Barbora Zelinková - zelinkobar@natur.cuni.cz 1 - P. schultei 2 - A. echii 3 - L. arundinis (B) 4 - L. arundinis (A) 5 - L. arundinis (C) 6 - L. artemisiiae 7 - B. reticulatus . Fig.5 * PYSZKO, Petr, Hana ŠIGUTOVÁ, Miroslav KOLAŘÍK, Martin KOSTOVČÍK, Jan ŠEVČÍÍ K, Martin ŠIGUT, Denisa VIŠŇOVSKÁ and Pavel DROZD, 2024. Mycobiomes of two distinct cla des of ambro sia g all mid ges (Dipte ra: Cecidomyiid ae) are species-speci fic in lar vae but simi la r in nutritive mycelia. Microbiology Spectrum [online]. Available at: doi:10.1128/spectrum.02830-23 a b c Ambrosia gall midges (AGMs) are specialized Dipteran insects known for inducing galls, mostly on specific kind of host plants. These galls serve as intricate habitats where AGMs cultivate fungal symbionts in an ambrosia layer, a probable source of their nutrition. Additionally, AGMs may engage in phytomycetophagy, a unique feeding behaviour involving the consumption both of plant biomass and mycelium. The most commonly identified fungal species from mycelial layer is Botryosphaeria dothidea (Ascomycota: Dothideomycetes), which is known as a worldwide endophytic and pathogenic species threatening agricultural crops - currently Vitis vinifera. However, despite its frequent occurrence, B. dothidea has not been the subject of many studies on the significance of its secondary metabolites and their effect on the host plant, the insect larvae, or their possible involvement in gall initiation. Fig.1 - Asphondylia sarothamni on Cytisus Fig.2 - Opened gall of Asphondylia echii with pupa on Echium vulgare Fig.3 - Different stages of B. dothidea Fig.4 - Mycobiomes - Pyszko et al. (2024)* Fig.5 - Stable isotope compositions (preliminary data) To gain a better understanding of the interactions between fungi, larvae, and host plants, our next steps include determining the diversity and taxonomy of gall symbionts using metabarcoding (ITS for fungi, 16S for bacteria) followed by multilocus approach (TUB2, TEF1a) for problematic taxa. We will also explore the secondary metabolites, particularly those produced by Botryosphaeria dothidea, and their role in gall formation, insect development, and coexistence with other symbiotic fungi. Research on gall-associated fungi has primarily relied on cultivation methods, often neglecting potential larval endosymbionts. We used ITS2 rRNA metabarcoding to analyse the mycobiomes within different gall compartments (gall surface, gall interior, and larva) across six species from two phylogenetically distinct tribes (Asphondyliini and Lasiopterini) - Fig.4. The mycobiome of the gall interior was primarily dominated by Botryosphaeria dothidea (except in Lasioptera arundinis), confirming the long-standing hypothesis of its significant evolutionary association with AGMs. Feeding strategy of young Cecidomyiidaes is unknown for each particular species. The stable isotope compositions of carbon-13 (δ^13C) and nitrogen-15 (δ^15N) in Cecidomyiidae larvae (Asphondylia echii, Lasioptera artemisiiae, and Lasioptera arundinis) compared with those of strict phytophagous (Peruphasma schultei) and strict mycophagous (Bolitophagus reticulatus) species (Fig.5) distingues if their diet is leaning closer to phytophagous or mycophagous. ¹ Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic ² Department of Zoology, Faculty of Science, Palacký University, Olomouc, Czech Republic ³ Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic Fig.1 Fig.3 Petr Pyszko¹, Hana Šigutová¹'², Miroslav Kolařík³, Martin Kostovčík³, Jan Ševčík¹, Martin Šigut¹'³, Denisa Višňovská¹'³, Pavel Drozd¹, Eva Stodůlková³, Lenka Machová³, Barbora Zelinková³ Sincere thanks to the Czech Science Fund (GA23-07026S) for funding this project and Strategie AV21 project “VP33 MycoLife – the world of fungi” of


GATE-Time: Extraction of Temporal Expressions -and Events! Leon Derczynski Jannik Strötgen Diana Maynard Mark A. Greenwood Manuel Jung Time is critical to language • required to discuss past events, change, or plans • most information bounded in time: the sky isn’t always blue, George W Bush did not reign forever TimeML is an ISO standard for annotating time in language GATE is an established NLP platform We annotate time in language using GATE and following TimeML Temporal expressions are things like dates, times, and durations We find these using HeidelTime It marks up the times in the text .. e.g. “Can we reschedule for the Tuesday after next please” .. and links them to a calendar. We find events by upgrading an older system (Evita) The SVM/UM learns to find event words by exploiting the fact that most words aren’t events This gives us fast, flexible, state of the art performance Also, because GATE applications are modular, other Applications can be added * TIMEN * TimeNorm * Temporal co-reference GATE-Time is an open, modular, and supported tool for temporal information processing. Use it! PHEME


Workflow of sequential rotor blade fatigue test and post-fatigue static test procedure — Full scale Fatigue tests are an important part in the certification process of new wind turbine rotor blade designs. As the blades are designed longer and closer to material limits, the fatigue tests are more time-consuming, and high overloading is more critical. By splitting the fatigue test into multiple test sequences on specific sections of the blade and accumulating the fatigue damage, the overloading can be reduced drastically, and a lot of time can be saved. Introduction Modern wind turbines have a higher rated power and longer more slender rotor blades compared to earlier designs. Thus, facilities performing full scale blade tests for certification need to be upgraded for static and fatigue testing to introduce larger loads and deal with larger tip deflections. Also, the test methods need to be adapted to avoid high overloads and reduce testing time. The most time-consuming part of the test campaign is the fatigue testing according to the current standards [1]. To introduce a damage equivalent load of a lifetime of 20-25 years rotor blades are subjected to cyclic loading with resonant excitation. Due to the lower natural frequencies of larger blades the conventional fatigue tests take even longer. Also, to sufficiently test the whole region of interest, high local overloads must often be accepted, possibly leading to premature damages, which need to be repaired mid-test. To reduce the peak loads, higher cycle numbers are required further prolonging the test. By cutting the blade into two segments (root and tip) and testing both segments simultaneously at higher natural frequencies as described by Ha et al. [2], the test duration can be reduced, but the mid-section around the cutting position cannot be tested sufficiently, which could also be overcome by using overlapping segments from two rotor blades. However, here an alternative method is proposed requiring only one rotor blade. Methodology In the proposed approach called “sequential testing”, the damage is introduced by multiple tests, each of which contributes to the resulting fatigue damage by linear damage accumulation. In the first test, the whole blade is tested with a similar setup as during a conventional test. The root and tip areas are not fully tested during the first test, which reduces the overloading in higher loaded areas. then the blade is cut into two (or more) segments, which are then tested simultaneously in separate test setups, at higher frequencies to accelerate the overall test. These setups are chosen to introduce the remaining fatigue damage in the previously undertested areas of the blade. The fatigue damage of all tests is accumulated to achieve the target damage in the whole region of interest, while drastically reducing overloads compared to conventional tests. The resulting reduction in local peak load allows for a higher load level overall reducing the required load cycles and therefore the testing time. The post-fatigue static tests also need to be executed in separate tests for each target region as shown in the workflow figure (left). The different test setups need to be attuned to one another. To find a good set of suitable test setups, including cutting position, additional masses and excitation, a numeric optimization is required. This was done based on a FE-Beam model and the simulation method by Melcher et al [3]. Furthermore, a quality measure for damage conformity was introduced. See the full paper for further details. Example As it is generally more difficult to reduce overloading in lead-lag fatigue testing than in flapwise fatigue testing, the proposed method is applied here by way of example to the lead-lag test of a current offshore rotor blade design of over 110 m in length with a region of interest between 7% and 90% blade length. A set of setups for sequential testing and a conventional test setup for comparison were designed


Acknowledgements: Contact email: schakdar@holycross.edu This research work is supported by the College of the Holy Cross’s Bachelor Ford Summer Fellowship 2020 References: 1. P.Q Hung, Phys. Lett. B649 (2007) 275279, arXiv: 0612004 2. S. Chakdar, K. Ghosh, V. Hoang, P. Q. Hung and S. Nandi, Phys. Rev. D95 no. 1, (2017) 015014, arXiv:1606.08502 3. S. Chakdar, K. Ghosh, V. Hoang, P.Q Hung and S. Nandi, Phys.Rev.D 93 (2016) 3, 035007, arXiv: 1508.07318 Particle Content Prospect of singlet scalar DM candidate in the EW scale-!" model Shreyashi Chakdar1, Dilip Ghosh2, P. Q. Hung 3, and Najimuddin Khan2, 1 College of the Holy Cross, 2Indian Association for the Cultivation of Science, 3University of Virginia Neutrino mass is the only evidence of BSM Physics so far! • Neutrino (ν) masses → popular “Seesaw mechanism” • In general Seesaw Mechanism: #$ →&' 2 )×' 1 , singlet • RH neutrino mass at GUT scale! NOT directly testable at LHC • Stand scenes: L-R : mD ~ Λ EW , MR ~MWR , GUT: MR ~ Λ GUT #$’s are Sterile in standard scenarios • What if MR ~ Λ EW? Can #$ ’s be non-sterile? Solution: • SM + Mirror Fermions + extended scalar sector Gauge Group : SU(3)c x SU(2)W x U(1)Y • . = 0 12 3 14 3 5678 92= 1 (custodial global symmetry SU(2)) • #1~ : (Λ=>) →A “large” triplet vev spoils . = 1 at Tree level • To restore the Custodial symmetry, a triplet Higgs scalar @ = (3, , 8 = 0) is added to the scalar sector such that • The Higgs potential has a global &' 2 ) × &' 2 $ symmetry →&' 2 D • The nature of EW symmetry breaking is intrinsically linked to Majorana mass of the non-sterile RH E • Physical scalars are grouped into Custodial SU(2)D states: 18 physical scalars grouped 5 + 3 + 3 + 3 + 3 + 1 Quintet →FG ±±, FG ±, FG I Triplet →FJ ±, FJ I, F′J ±, F′J I, F1 ±, F1 I , F1 L±, F1 LI Real Singlet →FM I, F′M I, FM1 I , FM1 LI , FMI, FM NI Complex Singlet →ON I Singlet States: Vev’s satisfy: • 6 mass eigenstates are denoted by P FQ, P F, RF’, RF’’, RF’’’, RF’’’’ • P FN →lightest (DM), next heavier ones are RF’, RF’’, RF’’’, with heaviest state RF’’’’ and RF →125 GeV • The pseudo singlet scalar is the DM candidate (Mev-GeV mass range) • The main contribution to the DM effective annihilation cross-section comes from annihilation channel ONI ONI →SM SM, (diagrams below) • Relic density related to annihilation cross-section and decay lifetime • Framework has Majorana and new mirror fermion masses within the reach of the current colliders • Complete scalar sector spectrum including heavier triplets, doublets and singlet Higgs states in conjunction with the current 125-GeV LHC data is analyzed • Prospect of the singlet scalar fulfilling the role of the DM candidate is investigated wrt the current bounds • EWE$ scenario links neutrino mass, DM studies and Long-lived Particles (LLP) searches at the Collider Extended Scalar sector Singlet Scalar • ONI = \∅NI^ , the complex singlet is investigated to be DM candidate in this analysis • At tree level, the mass of the complex singlet scalar ON I= \∅N I^ is given by • In gen, RFNI, F8 I, FM1 I , F81 I , FNI and FM I_ components can mix through • Two doublets in each sector, coupling to up and down components • Yukawa part of the Lagrangian is given by: Benchmark Points and experimental data Summary Dark Matter Model and Framework TABLE I: Branching Ratios for SM-like Higgs (`a ~ 125 GeV) decaying through various SM and BSM channels for a model Benchmark Point TABLE II: Signal Strengths for the Higgs-like Boson for the benchmark point examined in Table I MAs 0 <Mh/2 3 band in DMh2=0.1198±0.0026 MAs 0= 85 c (v1 + v2) (v1 M + v2 M) 1 0 As 0As 0 coupling: 4 a v1+2 5 c (v1 M+v2 M) 2 0 As 0As 0 coupling: 4 a v1+2 5 c (v1 M+v2 M) Allowed from Direct detection (Xenon 1T) 20 50 100 200 500 10-4 0.01 1 100 Mass of the Dark Matter MAs 0 (GeV) As 0h2 Fig: Plot shows variation of relic density (Ωℎ8) vs Dark matter mass. The red line signifies bounds coming from the recent direct detection xenon 1T data. The blue band


Shifting Terms and Concepts: From Defence to (Human) Security Introduction Over the last two decades, the concepts of defence and security have overlapped to the point where the former is merged with the latter. Since jihadist terrorism broke out at the dawn of the millennium, governments have been forced to review the classic paradigm according to which the military is employed in overseas operations—or the defence of the homeland from external enemies—and police and law enforcement agencies are tasked with internal security. In such a context, the military has taken on an increasing role in national security matters, although security itself is an umbrella concept under development that currently includes such cross- cutting topics as terrorism, cyber threats, health, food, energy, the economy, poverty, climate change, information technology, social security, job security, just to mention a few. The inclination to replace the idea of defence with security has contributed to the expansion of the idea of security itself. This way, defence activities abroad, such as military assistance to Ukraine in the context of the ongoing conflict with Russia, are presented to the public as "security" operations. Data analysis The author of this work has checked the multi-sectoral approach to security outlined by the UN and the NATO against commonly accepted versions of human security through a comparative study of the definitions provided by well-established and reputable dictionaries such as Merriam-Webster, Britannica, Collins, Oxford, Cambridge, Longman, and Macmillan. Such dictionaries provide similar definitions of the term "security": safety; safety from attack, harm, or damage; freedom from danger or threat; freedom from fear or anxiety; being safe and free from worry; being protected or safe from harm. Security is the protection from, or resilience against, the potential harm caused by others by restricting one's freedom to act. Conclusions The human security approach broadens the scope of security analysis and policy from the traditional notion of national security to the security of people and their complex social and economic interactions. The term "defence", is given as a synonym of "security" by the majority of these dictionaries (Merriam-Webster, Cambridge, Oxford, Collins), even though Britannica and Macmillan continue to be anchored to the dichotomy of defence/external and security/internal, respectively, by providing the words "national security" and "internal security", is evidence of this trend. The evolving concept of security must be scrutinised, with special attention paid to the notion of human security, boosted by UN General Assembly resolution 66/290 and the NATO Strategic Concept 2022, and currently under investigation by the Exploratory Team of the NATO Science and Technology Organization. So far, the meaning of “human security” remains unclear. References 1. United Nations Development Programme (UNDP), Human Development Report 1994: New Dimensions of Human Security, New York, UN, 1994. 2. UN General Assembly (UNGA), Follow-up to paragraph 143 on human security of the 2005 World Summit Outcome, resolution adopted on 25 Oct. 2012, A/RES/66/290, in GAOR, 66th sess., Suppl. no. 49. 3. NATO Heads of State and Government, Warsaw Summit Communiqué, 9 July 2016, Press Release (2016) 100. 4. NATO Heads of State and Government, London Declaration, 4 dec. 2019, Press Release (2019) 115. 5. NATO Heads of State and Government, Brussels Summit Communiqué, 14 June 2021, Press Release (2021) 086. 6. NATO Heads of State and Government, Madrid Summit Declaration, 29 June 2022, Press Release (2022) 095. 7. NATO Strategic Concept 2022, adopted at the Madrid Summit, 28-29 June 2022. 8. NATO, Human Security: Approach and Guiding Principles, https://www.nato.int/cps/en/natohq/official_texts_208515.htm?s electedLocale=en. 9. Marsili, Marco, The Role of the Armed Forces in Homeland Security, in Book of Abstracts of the XI Portuguese Con


Current Work Contribution Role Ontology (CRO) The CRO, shown in the diagram at the right, was developed by the FORCE11 Attribution Working Group. This ontology extends the publication author roles in the Contributor Role Taxonomy (CRediT) based on an in-depth investigation of activities and outputs and requirements evaluation, in order to create a contributorship model that not only covers a diversity of contribution types beyond publications, but also covers a variety of research fields and is specific enough to meaningfully describe contribution. https://github.com/openrif/contribution-ontology SciENcv Alignment This work aims to align the US Federal Science Experts Network Curriculum Vitae XML Schema, which is used to create biographical sketches for federal funding applications, with the VIVO-ISF ontology. Goals include expanding the role of SciENcv in data exchange, widening the set of data sources used in research profiling analytics, and broadening the definition of researcher impact by facilitating the emergence of new standards relating to the contribution and attribution of researchers to a variety of scholarly products. This work is supported by NIH/NCATS Award 3 UL1 TR000128-10S1. https://github.com/openrif/sciencv-integration VIVO for Historical Persons (VIVO4HP) VIVO4HP is a project to extend the VIVO-ISF ontology to accommodate historical persons, using early Stuart diplomats. Current extensions address modeling diplomatic missions and historical dates. https://github.com/openrif/vivo4hp Who we are and what we contribute: The Open Research Information Framework as a means to understand scholarship Marijane White1, Shahim Essaid1, Matthew Brush1, Karen Gutzman3, Alexandre Rademaker4, Tenille Johnson5, Muhammad Javed6, Jon Corson-Rikert6, George Chacko7, Mike Conlon8, Alex Viggo9, Thea Lindquist9, Kristi Holmes3, Melissa Haendel1,3, Violeta Ilik3 1Ontology Development Group, Library, 2Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR; 3Galter Health Sciences Library, Northwestern University, Chicago, IL; 4IBM Research, Rio de Janerio, Brazil; 5Harvard Medical School, Boston, MA; 6Cornell University, Ithaca, NY; 7NET Esolutions Corporation, McLean, VA;8Duraspace, 9University of Colorado Boulder, Boulder, CO Follow Us! @OpenRIF http://www.openrif.org openrif-community@googlegroups.com Contribute! http://www.github.com/openrif openrif-dev@googlegroups.com What OpenRIF OpenRIF, the Open Research Information Framework, is an open source community devoted to representing the expertise ecosystem — all the things we do and all the things we contribute — by developing and promoting interoperable and extensible semantic infrastructure. Semantic Frameworks • VIVO Integrated Semantic Framework (VIVO-ISF), which represents people, works, and the relationships between them • Federated databases modeled on PARDI, the Portfolio Analysis and Reporting Data Infrastructure, for research impact and evaluation • eagle-i, which aims to make discoverable research resources and their relationships to scholarly activities. Alignment Opportunities OpenRIF seeks to align with other knowledge representation efforts: Future Work Implement Ontology Change Management • Formalize process for versioned ontology changes • Learn from the success of the Schema.org community Modularize the VIVO-ISF Ontology • Create external ontology modules • Create sub-graph ontology modules • Allow VIVO instances to use only the ontology they need Develop New Modules Research Outputs Ontology Academic Degrees Taxonomy Grants Taxonomy Expand Domain Coverage Beyond academic research and scholarship: • Industry Research • Open Source Software Contributions Align with Schema.org • Facilitate Search Engine Optimization (SEO) for web applications using VIVO-ISF Join the OBO Foundry Library • Increase exposure and usage of VIVO-ISF OpenRIF: Representing Expertise Ecosystems Why • Improve academic reporting by


Syntheঞc Natural Xenobiology Syntheঞc Biology Geneঞc Firewall Classic Gene Technology Alternaঞve Genomes Refactored Genomes Syntheঞc Genomes Syntheঞc Alleles Transgenic Variants Directed Mutaঞons Random Mutaঞons Natural Isolaঞons


CARTE: Pretraining and Transfer for Tabular Learning Myung Jun Kim, Léo Grinsztajn, Gaël Varoquaux Pretrain Models for Tabular Learning Context-Aware Representation of Table Entries Schema Matching Not Required for CARTE Key Ingredients from CARTE GitHub Datasets Paper ▪Generalization of table entries with graph representation ✓No schema or entity matching across tables ▪Pretrain from large knowledgebases (knowledge graphs) ✓Train over 18.1 million triplets of 6.3 million entities in YAGO ▪Graph-attentional network that leverage context in tabular data Three key components of CARTE: Background information to downstream tasks Finetuning Strategies of CARTE CARTE Markedly Outperforms the Alternatives Entity Matching Not Required for CARTE More than LLMs: modeling numbers Toward tabular foundation models [Graph Representation] [Pretrain] [Graph-Attentional Network] ▪Finetune CARTE for single-tables and multi-tables ▪Bagging strategy on train/validation splits ▪Limit the number of layers 51 datasets representative of modern data science applications [Regression] [Classification] Extensive comparison over 42 baselines for tabular learning Preprocessing Methods TableVectorizer (TabVec) Target Encoder (TarEnc) Sentence-LLM (S-LLM) FastText Embeddings (FT) LLM Embeddings (LLM) Estimators CARTE CatBoost XGBoost (XGB) HistGradBoosting (HGB) RandomForests (RF) Linear (Ridge / Logistic) NN Models (ResNet / MLP) TabPFN Abundant but heterogenous tabular data ▪Manual entity matching of the entries to their corresponding YAGO entity ▪Knowledge graph embeddings (KEN) require entity matching to have good performance ▪CARTE is robust to entity variants Results over four datasets with manual entity matching: ▪Tables with meaningful columns and discrete entries Groups covering the same general topic but from different sources ▪12 topics - 125 cases for two-tables and 245 cases for multiple-tables [Comparison on Two-Tables] [CARTE Across Multiple-Tables] CARTE provides consistent improvements without column matching CARTE further benefits from additional source tables Performance boosting architecture ① “George Bush”? 41st or 43rd president? ② ‘Term’ and ‘Incumbency’ are they same columns? ③ ‘London’ and ‘Londres ’ are they same entities? Ambiguity in schema and entity resolution Different table specifications ✓Number of columns, inference tasks Out of vocabularies


All Errors Are not the Same: Different Memory Profiles between Aging, Alzheimer's Disease and Semantic Dementia from a New Memory Test G.T. Vallet1,2, M. Simard2,4, J. Macoir3,4, C. Hudon2,4, N. Bier5,6, & R. Versace1 1 Laboratoire EMC, Lyon 2 University, Lyon, France 4 CRUSMQ, Quebec City, Canada 2 School of Psychology, Laval University, Quebec City, Canada 5 École de Réadaptation, Université de Montréal, Montréal, Canada 3 Département de Réadaptation, Université Laval, Quebec City, Canada 6 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada Memory Group Age Education Gender (M/F) MMSE (/30) Young (n=55) 24 (3.7) 16 (2.6) 15/40 30 (0.3) Elderly (n=36) 73 (6.9) 14 (5.1) 8/25 29 (1) Alzheimer's Disease (n=16) 76 (7.8) 14 (4.3) 5/11 24 (2.6) Semantic Dementia (n=3) 66 (11) 14 (1.2) 3/0 27 (2.1) Episodic Semantic Young OK OK Elderly +/- OK Alzheimer's Disease OUT +/- Semantic Dementia +/- OUT Memory Errors? Elderly False memories → Alzheimer False memories & intrusions → Semantic dementia Semantic errors → How to differentiate clinical populations? Few clinical tests rely on a qualitative approach Populations Episodic/Semantic Memory Test Adaptation of the Pyramid and Palm Trees Test Learning phase Test phase Material 32 cards with 3 line-drawing items: (1) reference (2) good match (3) distractor 64 cards: - 32 good matches - 16 distractors - 16 new items Tasks Matching task Learn the correct match Free recall Recognition task Delayed free recall Naming task Learning phase Errors qualification Reference Good match Item to learn Distractor Distinct Memory Profiles Conclusions Distinct profiles: Semantic Dementia (/others) ←→ Semantic errors Aging (/young) ←→ Confusions Alzheimer's Disease (/others) ←→ Intrusions HIT CONFUSION OR INTRUSION PPTT / Buschke Encoding Sum Free Recall Sum Cued Recall Delayed Free Recall Matching -0.14 0.22 0.12 -0.14 Free Recall 0.17 0.60* 0.46* 0.42* Free Recall – Conf 0.1 0.03 0.11 0.01 Delayed Free Recall 0.1 0.50* 0.25 0.35* Delayed Free Recall – Conf 0.09 -0.43* -0.39* -0.26 Recognition -0.01 0.34* 0.21 0.1 Recognition – Conf -0.07 0.08 -0.05 -0.11 Naming -0.05 0.14 0.18 -0.19 A validated memory test Notes. Correlations between the PPTT adapted and the Buschke memory test. Conf = confusions; * = p<0.05; Intrusions not included due to lack of variance. A valid memory test? - episodic memory test (correlations) - semantic memory test (remain to be assessed) Use a qualitative approach of memory errors Young


Contact Sören Tholen (PhD student) Jolien Linckens (PhD) Stuctural Geology Goethe University Frankfurt tholen@geo.uni-frankfurt.de linckens@em.uni-frankfurt.de +49 (0) 69 798 40194 - R e c r y s t a l l i z a t i o n m e c h a n i s m , m i x i n g i n t e n s i t y a n d n e o b l a s t a s s e m b l a g e d e p e n d e n t o n r e c r y s t a l l i z e d p h a s e a n d i t s m i c r o s t r u c t u r a l p o s i t i o n . - P h a s e m i x i n g i s s i m u l t a n o u s t o r e c r y s t a l l i z a t i o n o f o p x a n d c p x p o r p h y r o c l a s t s i n c o n t a c t t o o l - m a t r i x . - O l p o r p h y r o c l a s t s r e c r y s t a l l i z e b y d y n a m i c r e c r y s t a l l i z a t i o n w i t h m i n o r a m o u n t s o f m i x i n g b y G B S . - T h i s s t u d y h i g h l i g h t s t h e i m p o r t a n c e o f n e o b l a s t n u c l e a t i o n f o r p h a s e m i x i n g ; M e c h a n i c a l m i x i n g s o l e l y b y g r a i n b o u n d a r y s l i d i n g i s n e g l e c t a b l e i n t h e i n v e s t i g a t e d L a n z o s h e a r z o n e . C o n c l u s i o n :                                                                                ¡                                             ¢ C l i n o p y r o x e n e p o r p h y r o c l a s t s r e c r y s t a l l i z e f r o m p o r p h y r o c l a s t i c t e x t u r e s o n w a r d s f o r m i n g a n i n s t a n t m i x o f c p x ( ~ 6 1 a r e a % , ~ 2 1 µ m ) a n d o l ( ~ 3 1 a r e a % , ~ 1 8 µ m ) i n m y l o n i t e s ( 1 ) . C p x g e n e r a l l y d i s p l a y s b i g g e r g r a i n s i z e s a n d h i g h e r a b u n d a n c e s t h a n o p x i n o l + o p x a s s e m b l a g e s . M i x i n g i n t e n s i t i e s a r e e x p l i c i t l y h i g h ( 6 6 % p h a s e b o u n d a r i e s ) . R e c r y s t a l l i z a t i o n s i d e s i s o l a t e d f r o m t h e o l - b e a r i n g m a t r i x s h o w a s i g n i f i c a n t l o w e r a m o u n t o f p h a s e m i x i n g ( 2 ) . C l i n o p y r o x e n e R e c r y s t a l l i z e d c p x p o r p h y r o c l a s t s i s o l a t e d f r o m o l - b e a r i n g m a t r i x R e c r y s t a l l i z e d c p x p o r p h y r o c l a s t s i n c o n t a c t t o o l - b e a r i n g m a t r i x U p t o m y l o n i t i c t e x t u r e s o r t h o p y r o x e n e o c c u r s a s ± e q u i a x i a l p o r p h y r o c l a s t s a n d b a n d s . I n m y l o n i t e s b o t h r e c r y s t a l l i z e , f o r m i n g a n i n s t a n t f i n e - g r a i n e d m i x t u r e o f o l ( ~ 5 6 a r e a % , ~ 1 3 µ m ) a n d o p x n e o b l a s t s ( ~ 3 7 a r e a % , ~ 1 4 µ m ) ( 1 ) . T h e p h a s e m i x i n g i n t e n s i t y i s e x c e p t i o n a l l y h