Efficient Approaches for Online Training of Gaussian Process Models in Multi-objective Coastal Groundwater Management Weijiang Yu1, Domenico Ba𝐮̀ 1, Alex S., Mayer2, Mohammadali Geranmehr1 1Department of Civil and Structural Engineering, University of Sheffield, UK. 2Department of Civil Engineering, University of Texas at El Paso, USA. Abstract: In coastal groundwater management, data-driven surrogate models constitute attractive tools for replacing complex groundwater simulators, providing aquifer response to pumping at a fraction of the computational costs. For simulation-optimization assisted management, building an “online” trained surrogate involves updating it at each iteration by incorporating newly identified optimal pumping patterns into the training set, enabling the derived optimal pumping solutions to gradually converge towards the ones that would be found when using full-scale simulators. This approach, however, it may be computationally challenging in multi-objective management scenarios that involve multiple non-dominated solutions. This study aims to explore efficient sampling strategies for online training of surrogates. To this end, a two-objective pumping optimization problem is initially formulated based on hydrogeological conditions observed on San Salvador Island, Bahamas. Gaussian Process (GP) techniques are employed to construct model surrogates, and four online sampling strategies are proposed. For any given pumping scheme, GP models are used emulate management objectives and constraints, alongside quantifying associated uncertainties. By conducting repeated stochastic simulations using these fast GP models, it becomes possible to ascertain the probability of Pareto-optimality for each pumping scheme. Performance assessment of each training strategy involves determining the average probability of Pareto- optimality and evaluating the correlation between predictions. Findings of this study reveal a most suitable online sampling strategy for GP models among those proposed. Keywords: groundwater management, seawater intrusion (SWI) control, optimal pumping strategies, offline training, Gaussian process (GP) model


Electronic properties of vacancy ordered double perovskites B. Cucco1, G. Bouder1, M. Kepenekian1, J. Even2, L. Pedesseau2, C. Katan1, G. Volonakis1 1Univ Rennes, INSA Rennes, Institut des sciences chimiques de Rennes, CNRS, France 2Univ Rennes, INSA Rennes, CNRS, Institut FOTON - UMR 6082, Rennes, France 1C. E. Patrick and F. Giustino, J. Phys. Condens. Matter 24, 202201 (2012) 2M. G. Ju, ACS Energy Lett., 3, 2, 297–304 (2018) Structure Splitting of the d-states Stability Optics ABX3 A = +1 (Cs) B = +2 (Pb) X= -1 (Cl, Br, I) A2BB’X6 A = +1 (Cs) B = +3 (In) B’= +1 (Ag) X = -1 (Cl, Br, I) A2BX6 A = +1 (Cs) B = +4 (Ti, Zr) X = -1 (Cl, Br, I) Electronic Properties • Cs2TiBr6 : 1.57 eV • Cs2ZrI6 : 1.65 eV DFT@GGA J. Phys. Chem. Lett. 2017, 8, 4, 772–778 Without SOC 3.87 eV 2.68 eV Band Gap (eV) DFT@PBE DFT@HSE06 Cs2TiBr6 1.57(1.64) 2.68(2.74) Cs2ZrI6 1.65(1.67) 2.58(2.59) • GoWo@HSE06 • Auto-consistent GoWo@DFT+U1 Quasi-particle corrections 2Experimental gap ~ 1.8 eV Summary • Investigation of the Ti/Zr-based VODP • The Cs2ZrI6 exhibit smaller band gap and effective masses, better stability and similar optical properties when compared to the reference Cs2TiBr6 Band structure and symmetry Charge density distribution Effective masses and its origins Quasi-particle corrections Chemical and dynamical stabilities Optical properties Acknowledgements This project has received funding from the European Union’s Horizon 2020 research and in- novation Programme under the grant agreement No 862656. The information and views set out in the abstracts and presentations are those of the authors and do not necessarily reflect the official opinion of the European Union. Neither the European Union institutions and bodies nor any person acting on their behalf may be held responsible for the use which may be made of the information contained herein. Figure extracted from ref. 1


Lehrstuhl für Abfallverwertungstechnik und Abfallwirtschaft (AVAW) Department für Umwelt- & Energieverfahrenstechnik Montanuniversität Leoben Franz-Josef-Straße 18, 8700 Leoben, Österreich Telefon: +43 (0) 3842 / 402-5101, Fax: -5102 E-Mail: avaw@unileoben.ac.at, Homepage: avaw.unileoben.ac.at Equipment used: NIR Sorter in MUL Conclusion: • PHB has a distinct spectra & was sorted out from mixed plastic fraction for all the 10 trials. • Present research contributes to the field of Group 1 bioplastics waste management through NIR sensor- based sorting. Results: A B C D E F Spectra after pre-processing (1st derivative, smoothing and normalization) Bibliography: 1. Briassoulis, D., Pikasi, A., & Hiskakis, M. (2019). End-of-waste life: Inventory of alternative end-of-use recirculation routes of bio-based plastics in the European Union context. https://doi.org/10.1080/10643389.2019.1591867 2. Briassoulis, D., Pikasi, A., & Hiskakis, M. (2020). Recirculation potential of post-consumer /industrial bio-based plastics through mechanical recycling - Techno-economic sustainability criteria and indicators. Polymer Degradation and Stability, 109217. https://doi.org/10.1016/j.polymdegradstab.2020.109217 3. European Bioplastics. (2020). FREQUENTLY ASKED QUESTIONS ON BIOPLASTICS. European Bioplastics. https://docs.european- bioplastics.org/publications/EUBP_FAQ_on_bioplastics.pdf 4. Helena Wedin, C. Gupta, Pailak Mzikian, F. Englund, R. Hornbuckle, Vittoria Troppenz, Lucijan Kobal, M. Costi, D. Ellams, & S. Olsson (2017). Title : Can automated NIR technology be a way to improve the sorting quality of textile waste ? In 5. Lorber, K., Kreindl, G., Erdin, E., & Sarptaş, H. (2015). Waste Management Options for Biobased Polymeric Composites. In 6. Zhu, S., Chen, H., Wang, M., Guo, X., Lei, Y., & Jin, G. (2019). Plastic solid waste identification system based on near infrared spectroscopy in combination with support vector machine. Advanced Industrial and Engineering Polymer Research, 2(2), 77–81. https://doi.org/10.1016/j.aiepr.2019.04.001 Introduction: • Near-infrared (NIR) spectroscopy technology vastly used in waste sorting4,6. • Bioplastics market share increasing gradually1,2,3. • Currently, Group 1 bioplastics are incinerated1,3,5. • No present research on sorting of PHB using NIR sorter. • Research Question: Whether the NIR spectrum of polyhydroxybutyrate (PHB) coincide with the spectra of polylactic acid (PLA) and the 6 selected conventional plastics, and whether they could be sorted out from the mixed plastic fraction? Summary: • ESR 7 of Circular Plastics Network for Training (C-PlaNeT) project. • Research is focused on improving capture of Group 1 bioplastics via waste collection and sorting. 3 Bioplastic Groups Source: European Bioplastics Group 1 Group 2 Group 3 Evaluation of a near-infrared sorting system for bio-based and biodegradable plastics Namrata Mhaddolkar, Daniel Vollprecht Montanuniversität Leoben, Franz-Josef-Str. 18, A-8700 Leoben The project C-PlaNeT has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska Curie grant agreement No. 859885. Namrata Mhaddolkar namrata.mhaddolkar@unileoben.ac.at Samples used: PHB


Beamed super-Eddington emission from a weakly magnetized neutron star - an ultraluminous X-ray source (ULX) David Abarca⋆1, Kyle Parfrey2 & Włodek Kluźniak1 1Nicolaus Copernicus Astronomical Center, Polish Academy of Sciences 2School of Mathematics, Trinity College Dublin, Dublin 2, Ireland ⋆dabarca@camk.edu.pl Abstract We model an ultraluminous X-ray source using a global 2D axisymmetric general relativistic radiation magnetohydrodynamic simulation of super-Eddington accretion onto a neutron star with a 10 billion Gauss dipolar magnetic ﬁeld. We found that the magnetic conﬁnement of the gas into accretion columns along with the interaction of the gas with the neutron star surface produce a total luminosity of a few times the Eddington limit. Furthermore, this radiation is beamed by outﬂows from the accretion disk causing the apparent isotropic luminosity to exceed 1040 erg s−1, showing that low-magnetic ﬁeld neutron stars can be good candidates for the central engines of ULXs. Neutron stars power ULXs What is a ULX? • Bright, extragalactic object with X-ray luminosities L ≳1039 erg s−1. • Not observed in the central region of galaxies, i.e., not an active galactic nucleus/supermassive black hole. The Eddington luminosity LEdd = 4πGMmpc σT , for a 1 M⊙object is approximately 1040 erg s−1. Bachetti et al. (2014) observed a ULX along with ∼1 s coherent pulsations, indicating a neutron star accretor with a super-Eddington luminosity. About a dozen such objects have been found, and there is evidence that even non-pulsating ULXs may be powered by neutron stars (King et al. 2017; Wiktorowicz et al. 2017). GRRMHD simulations Super-Eddington accreting neutron stars are excellent systems for applying general-relativistic radiation magne- tohydrodynamics (GRRMHD). • Strong gravity from the neutron star requires general relativity. • Super-Eddington accretion mean radiation pressure becomes dynamically important which requires radiation hydrodynamics. • Accretion is inherently a magnetoturbulent phenomenon, which requires magnetohydrodynamics to describe properly. GRRMHD Equations ∇µ(ρuµ) = 0 Conservation of mass ∇µT µν = Gν Conservation of matter momentum-energy ∇µRµν = −Gν Conservation of radiation momentum-energy ∇µF ∗µν = 0 Source-free Maxwell’s equations 20 10 0 10 20 r[GM/c2] 14 15 16 17 18 19 log10 c E, [ergcm−3] 5 4 3 2 1 log10 ρ[gcm−3] Figure: Snapshot (upper) and time-averaged (lower) plots of the radiation energy density, left, and the gas rest-mass density, right. We plot equispaced contours of Aφ, the φ component of the vector potential, which correspond to poloidal ﬁeld lines due to the axisymmetric nature of the problem. A bold contour shows the remnant of a torus loop which had just reconnected with the neutron star’s dipole. Simulation details • We run the simulation using the Koral code (Sądowski et al., 2013, 2015) which solves the GRRMHD equations on a static grid for a ﬁxed metric. • Radiation is evolved using the M1 closure scheme (Levermore 1984). • We implement the method from Parfrey & Tchekhovskoy (2017) in order to handle large magnetizations. • We use a 2D axisymmetric grid with resolution in r and θ corresponding to [512, 510] cells. • We initialize the simulation from an equilibrium torus threaded by a weak magnetic ﬁeld. The neutron star magnetic ﬁeld is initialized to a dipole with a maximum ﬁeld strength of 2 × 1010 G. • The boundary condition is set to return a fraction (75%) of the inﬂowing energy as outﬂowing radiation. • The simulation is run for 80,000 GMc−3. Simulation Result As the simulation evolves, the magnetorotational instabil- ity develops in the disk driving accretion. The infalling gas hits the neutron star magnetic ﬁeld and is forced to accrete along magnetic ﬁeld lines, forming accretion columns. Gas hits the the neutron star surface and becomes shocked. Ra- diation escapes through the sides of the accretion column and reaches the observer through the optically thin funnel regions along t


Book of Abstracts of the 75th Annual Meeting of the European Federation of Animal Science Book of Abstracts No. 34 (2024) Florence, Italy 1-5 September, 2024


Delirios de Falsa Identificación: Diversidad clínica y de significación pronostica AUTORES: Zaida Gutierrez Hervás1, Maria E García-Llamas1,Sara Vega-García1, Michael C. Osorio Hualpa1, Eva Mª Romero Gomez1, Elena Martín Gil1, Yolanda Zapico Merayo1 José María Pelayo-Terán* 1, 2,3,4 FILIACIÓN: 1: Servicio de Psiquiatría y Salud Mental, Hospital El Bierzo. Gerencia de Asistencia Sanitaria del Bierzo (GASBI). SACYL, Ponferrada. 2: Unidad de Calidad y Seguridad del Paciente, Hospital El Bierzo. Gerencia de Asistencia Sanitaria del Bierzo (GASBI). SACYL, Ponferrada. 3: Área de Medicina Preventiva y Salud Pública. Departamento de Ciencias Biomédicas, Universidad de León, León. 4: Grupo CB07/09/2001, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid. INTRODUCCIÓN Y OBJETIVOS: Los delirios de falsa identificación, incluyen el delirio de Capgras y el de Fregoli, asociados tradicionalmente a la esquizofrenia. Objetivos: investigar la presentación de delirios de identificación en la práctica clínica en distintas patologías DESCRIPCIÓN DEL CASO - EXPLORACIÓN Y PRUEBAS COMPLEMENTARIAS  Caso 1: Mujer, 46 años, trastorno esquizoafectivo, delirios de Capgras, creyendo ser varias celebridades. Mejoró parcialmente con risperidona y olanzapina; a los 7 meses, está asintomática.  Caso 2: Hombre, 25 años, esquizofrenia y TEA, mostró delirio de intermetamorfosis, creyendo que era y se intercambiaba con su compañero de habitación. La respuesta a risperidona y litio fue insatisfactorias, por lo que se inicio clozapina, que fue suspendido por rechazo de paciente y familia. Mantiene clínica resistente y gran aislamiento.  Caso 3: Mujer, 64 años, esquizofrenia, delirio de capgras, convencida de que su psiquiatra había sido reemplazado por otras personas. Tratada con clozapina, mostró mejoría completa al alta.  Caso 4: Mujer, 31 años, hiperémesis cannabinoide, presentó delirios de Capgras e intermetamorfosis. Tras la resolución del desequilibrio electrolítico, los síntomas persistieron dos días más.  Caso 5: Mujer de 29 años, trastorno bipolar, delirio de Capgras, pensaba que sus padres eran suplantados por otras personas. Recibe tratamiento con AILP y permanece asintomática, realizando tratamiento intensivo en hospital de día y actualmente embarazada. DIAGNÓSTICO DIFERENCIAL Y TRATAMIENTO: Los delirios de identificación son complejos, presentes en el 10-15% de los pacientes con esquizofrenia, y también pueden aparecer en síndromes afectivos, neurológicos y orgánicos. Se


Acknowledgements This work has been supported in part by the National Library of Medicine Grant# T15LM007124 and National Center for Advancing Translational Sciences of the National Institutes of Health Award# UL1TR001067. Contact Information Jianyin Shao jianyin.shao@utah.edu Flow of Information Discussion • On the 4x4 curated criteria sets, HCB with Dice yields the best performance with relatively high intra-set similarity and relatively low inter-set similarity. • HCB can provide similarities that match human expert cognition. • Pre-processing CUIs improves the similarity comparison, especially filtering out CUIs that are too common or general. • Other approaches can be used to refine concepts, such as using UMLS concept semantic types. • For matching patient records, metadata of the EHR can be used to select appropriate semantic types of the CUIs for similarity comparison. Introduction • Evidence-base medicine relies on well- designed and performed reproducible research. • Clinical trials are the gold standard of experimental design for examining effects of clinical intervention on patients or populations. • Current clinical trial cohort recruitment approaches may not promote reproducible research due to • Ambiguous cohort definition and varied interpretation by clinical trial coordinators. • Biases of selection of cases and controls. • Formal semantic matching patient medical record with appropriate trial eligibility criteria could improve the reproducibility of the clinical trials. Jianyin Shao, PhD1, Ramkiran Gouripeddi, MBBS, MS1,2, Julio C. Facelli, PhD1,2 Improving Clinical Trial Cohort Definition Criteria and Enrollment with Distributional Semantic Matching 1Department of Biomedical Informatics, 2Center for Clinical and Translational Science, University of Utah, Salt Lake City, Utah, USA Method • Concept Bag: clinical trial eligibility criteria and/or patient medical records can be represented by a set of UMLS concepts. • Hierarchical Concept Bag: trial criteria and medical records can be represented by a set of UMLS concepts and their ancestors. • Concepts extracted by MetaMap. • Similarity metrics: Jaccard, Dice, Cosine. Results References 1. Bradshaw RL. Concept Bag: A New Method for Computing Similarity. Ph. D. Dissertation, University of Utah; 2015. 2. Aronson a R. Effective mapping of biomedical text to the UMLS Metathesaurus: the MetaMap program. Proc AMIA Symp. 2001;17–21. 3. Wilcox A, Natarajan K, Weng C. Using Personal Health Records for Automated Clinical Trials Recruitment: the ePaIRing Model. Summit Transl Bioinforma. 2009;2009:136–40. Trial Criteria Extract concepts Filter out common CUIs Filter out improper POS Expand Hierarchical CUIs Pair-wise similarity for 4 sets of 4 trial eligibility criteria using different pre-processing and metrics All CUIs Retention of CUIs of specific POS* Removal of common CUIs** * Retained noun, verb, adjective, adverb and numerical cardinal CUIs. ** A common CUI list of 1648 CUIs was compiled by manual review of 195 randomly selected trial eligibility criteria (all trials ending with “000”) EHR documents or notes Extract concepts Filter out common CUIs Filter out improper POS Expand Hierarchical CUIs Match bags Score > threshold Prompt for trial notification Point of care Clinic Manager Trial Coordinator PHR


10. M-COU in light of ΔR (Table on the left) Consider M-COU in the context of differences between R-V and R-COU. 7. Is it appropriate to use the model aspects listed in Step 4 to make predictions about R-COU? Provide rationale, evidence, or discussion. Assume that these model aspects are appropriate for R-V (or refer to the validation results) and then consider each of the differences in DR (listed in Step 6). If the validation comparison is deemed adequate, can we be confident that the aspects that are the same in M-V and M-COU, as listed in Step 4, are appropriate for the COU? Differences between R-V and R-COU, listed in Step 6, might mean that this is not so. For each aspect listed in Step 4, provide rationale, evidence or discussion on whether the model aspect is appropriate for the COU, Use the Table on right, and for each entry, ask: “is it acceptable to use this model aspect (associated column) for making predictions about R-COU, given this difference (row)?” 5. Describe ∆M Describe the aspects of the model that are different between M-V and M-COU • Phantom → virtual human • Path of device lead • … 3. Describe primary validation evidence Provide details on both the validation setting and the model for the validation setting. R-V: A saline-filled phantom implanted with the new device was placed inside an RF coil; temperature changes were measured… M-V: A geometrical model of the phantom was used with the embedded device with one RF coil. The EM/thermal model was used to compute temperature change… 1.Describe COU Provide details on both the ‘reality’ to be modelled and the model that will simulate ‘reality’. For example: R-COU: Estimate the worst-case temperature change in the tissue around the implant that might occur during MRI across a wide-array of parameters… M-COU: Solve an electromagnetic model and a thermal model using a human body anatomical model containing the device, to determine the maximum temperature change under simulated MRI conditions for a range of parameters that closely represent the clinical setting… 2. Sources of validation evidence Describe the different types of validation results and sources of evidence. Denote one as the primary validation evidence 1. Primary validation evidence: Phantom validation experiments using the new device. 2. Animal validation experiments using a previous version of the device. 3. All historical validation evidence regarding similar models with different devices. 4. Literature regarding electromagnetic simulations using human anatomical models 6. Describe ∆R Describe the relevant differences between R-V and R-COU • Phantom → human (both sexes, range of ages and BMIs) • Path of device lead • MR system present in R-COU, only RF coil in R-V • … Applicability Analysis for Biomedical Computational Models Pras Pathmanathan, PhD, Richard Gray, PhD, Leonardo Angelone, PhD and Tina Morrison, PhD APPLICABILITY ANALYSIS • Computational modelling has the potential to revolutionise 21st Century healthcare • However, despite decades of research, progress in translating computational models to clinical care has been limited. • One major challenge is demonstrating the reliability of predictions from in silico approaches Excellence in Regulatory Science Office of Science and Engineering Laboratories Model as used in context-of-use M-COU Reality being modelled R-COU ? Model as used in validation simulations M-V Validation comparator R-V Directly comparable Primary validation results Other COU-based validation results General validation results Subject matter expertise Historical data Established theory M-COU R-COU R-V M-V ΔM ΔR 4. Describe model aspects common between M-V and M-COU The model that was ‘validated’ using the primary validation evidence will likely vary from the model that is used for the context of use. However, there will be many aspects of the model that remain the same. Therefore, describe the aspects of the model that are equivalent between M-COU and M-V: • Maxwell’s eq


KARIOS : A fast & efficient open source tool for geometric deformation analysis. Sébastien Saunier(1), P. Canonici(1), V. Debaecker, J. Louis(1), A. Beaton(2), C. Albinet(3) (1)Telespazio France - A Leonardo / Thales Company, 26 Av. JF Champollion, 31023 Toulouse Cedex 1 (France), Phone: +33 534357501, Email: sebastien.saunier@telespazio.com (2) Telespazio UK (3) European Space Agency, ESRIN The Earthnet Data Assessment Project (EDAP+) continues the work of its predecessor (EDAP 2018 – 2021) and is responsible for assessing the quality and suitability of candidate missions being considered for ESA’s Earthnet Programme as Third Party Missions (TPM). Early data assessments are publicly disclosed to the community ([RD-1]). Based on its own infrastructure ([RD-2]), Telespazio is responsible for the analysis of Very High Resolution optical data, including assessment on geometry, radiometry and image quality ([RD-3]). In most cases, inherited from design tradeoffs in the new space domain, the geometry remains a critical aspect. Main outcomes from various workshops ([RD-4]) point out the needs regarding openly available reference data and openly available data assessment processing tools. In this context, a new tool dedicated to geometric assessment has been created: Kanade Lucas Tomassi (KLT) based Algorithm for Registration of Images from Observing System’ (KARIOS) Functionalities Activities funded by the ESA / Earthnet Programme Algorithms The main driver of KARIOS initiative is to support operator for following quality control assessments • Multi temporal geolocation to evaluate the geolocation stability of the mission, • Absolute geolocation to evaluate the geolocation accuracy of an input image grid against a well-controlled absolute reference image,. • Band-to band registration to evaluate co-registration between image band grids, all within a same product. The KARIOS tool has been designed to compare two image grids (matching) and output consistent mapping accuracy analysis statistics, Results Conclusions and Future Plans Multi temporal analysis KARIOS can be orchestrated to perform multi temporal analysis over large dataset. Small changes in Processing Baseline can be easily detected, notably systematic shifts between Landsat and Sentinel 2 products and improvements (end of the period) as show in right figure (upper graphics). KARIOS is also used to validate Sen2Like processing results (right figure (lower graphics)). Validation L1C processing (before Sen2Like (left / after (left) registration S1 / S2 Image grid comparison [RD-1] ESA/EDAP VHR, HR and MR Optical Missions Webpages, https://earth.esa.int/eogateway/activities/edap/vhr-hr-mr-optical-missions [RD-2] Saunier, S.: Reference Data and Methods for Validation of Very High Resolution Optical Data Within ESA / EDAP Project, EGU General Assembly 2021, online, 19–30 Apr 2021, EGU21-15501, https://doi.org/10.5194/egusphere-egu21-15501 [RD-3] Saunier, S.; Karakas, G.; Yalcin, I.; Done, F.; Mannan, R.; Albinet, C.; Goryl, P.; Kocaman, S. SkySat Data Quality Assessment within the EDAP Framework. Remote Sens. 2022, 14, 1646. https://doi.org/10.3390/rs14071646 [RD-4] The Very High-resolution Radar & Optical Data Assessment (VH-RODA) Workshop https://earth.esa.int/eogateway/events/vh-roda [RD-5] Kocaman, S., Debaecker, V., Bas, S., Saunier, S., Garcia, K., Just, D., 2022. A Comprehensive Geometric Quality Assessment Approach for MSG SEVIRI Imagery. Advances in Space Research. https://doi.org/10.1016/j.asr.2021.11.018 [RD-6] Shi, J., Tomasi, C., 1994. Good features to track. In IEEE Computer Society Conference on Computer Vision and Pattern Recognition Seattle, WA, USA, 21–23 June, pp. 593-600 [RD-7] Lucas, B. D., & Kanade, T., 1981. An iterative image registration technique with an application to stereo vision. International Joint Conference on Artificial Intelligence, 674–679 [RD-8] Saunier, S.; Pflug, B.; Lobos, I.M.; Franch, B.; Louis, J.; De Los Reyes, R.; Debaecker


Technische Universität Braunschweig Institut für Informationssysteme http://www.ifis.cs.tu-bs.de ESSENCE facilitates hot topic detection by visualizing the novelty of author’s keywords relative to a query over time. User satisfaction Especially in the context of exploratory search ESSENCE achieves remarkable results encouraging use to continue research in this direction. Exploratory search remains one of the major problems for scientific literature search in digital libraries. Faceted search GUIs for digital libraries enable filtering results for a well-defined user need. However, they fail to deliver an overview when familiarizing oneself with a new scientific topic. How do scientists approach a new subject area? User study: 15 computer scientists were asked to describe their approaches on performing literature search on a new subject. We identified two major ones: • Reading survey papers • Studying the evolution of authors’ keywords to identify hot topics over time ESSENCE – Time-Based Exploratory Search in Scientific Literature Silviu Homoceanu, Sascha Tönnies, Philipp Wille, and Wolf-Tilo Balke {silviu, wille, balke}@ifis.cs.tu-bs.de, toennies@l3s.de


Observations: q¹ Eri’s Disc is asymmetric Continuum emission: significantly detected Detailed exploration of the Band 7 image reveals the structure of this disc with a broad, inclined belt from ~23- 161 au, with a peak brightness radius at ~82au consistent in all directions from the star. Further, it is found inside this radius, i.e., on the inner edge, that the SW inner edge is closer to the star than the NE, and that this SW side of the disc has a higher integrated flux than the NE. Given the resolved nature of the disc and due to its inclination, we were able to observationally estimate the vertical aspect ratio at the few per cent level. CO J = 3-2 line emission: upper limit CO mass found Spectro-spatial filtering (Matrà et al. 2017) of the CO J=3-2 line was performed to investigate if any CO gas is present. A CO gas mass above 𝟒× 𝟏𝟎−𝟔𝑴Earth is ruled out. J. B. Lovell, S. Marino, M. C. Wyatt, M. A. MacGregor, K. Stapelfeldt, G. M. Kennedy, B. Dent, Q. Kral, J. Krist, L. Matrà, O. Pani'c, T. Pearce, D. Wilner References What lies beyond Exo-Jupiters? A High Resolution study of q¹ Eridani Abstract ALMA Band 6 (~1250μm) and 7 (~856 μm) observations of the >1Gyr F9V star q¹ Eri (HD 10647, HR 506) are presented, a system with a known ~2 au radial velocity planet (Butler et al. 2006) and debris disc. These resolve the broad, inclined debris disc, with a maximum brightness on both ansae at ~82au. The emission is asymmetric; the integrated flux is higher in the SW than the NE and the star is closer to the SW inner edge than the NE. HST data (Stapelfeldt et al. 2007) however have demonstrated that the scattered light is more radially extended in the NE direction. We modelled the disc, constraining its overall morphology and the origin of these disc asymmetries. We show that this is broadly consistent with a clump on the inner edge of the disc’s SW ansa. The inner edge clump is shown to be consistent with perturbations from a planet having trapped planetesimals following a period of migration, or due to a recent massive collision. Further, we constrain the vertical aspect ratio as h~5%, and show that if this is due to dynamical interactions in the disc, then this requires perturbers in the belt with sizes ~0.5 RPluto, consistent with the lower limit we set on the maximum planetesimal size (>km-sized). Conclusions 1: q¹ Eri has been imaged by HST, and ALMA in Bands 6 and 7. Our combined analysis of this planetary system’s data demonstrates that there is a broad, bright, inclined debris disk, with significant asymmetric features. 2: Modelling of the disc shows that these asymmetries can be explained by a clump in the SW of the disc, likely due to planetesimal collisions and/or planet-disc interactions. We detail this further in Lovell+ 2021 (in prep). Butler R. P., et al. 2006 ApJ, 646, 505 // Matrà L., et al. 2017 ApJ, 842, 9 // Stapelfeldt et al. 2007 Please note that this work, J. B. Lovell, et al. 2021, is still in preparation. Consequently numerical values and analysis may differ from those presented here. Joshua B. Lovell PhD Candidate, Institute of Astronomy, University of Cambridge JL638@cam.ac.uk Other work: available here Figure 1: Band 7 Image Figure 2: Models (top) & residual images (bottom) Institute of Astronomy, University of Cambridge, UK Disc Modelling: A Clump in the South-West Our observational analysis drives all scenarios considered in our sub-mm disc modelling, in which we consider a symmetric disc, an eccentric disc, and variants of these including a clump in the SW (see upper panel, Fig.2). We find the best fit to our data and our residual images is the symmetric disc with a clump (“CL”), given that this model: - fits the inner edge offset asymmetry; - fits the integrated flux asymmetry; - results in no residuals >3σ coincident with the disc. A recent collision or planet perturbations? We explore two possibilities: that the belt asymmetry is produced by either a large recent planetesimal collision, or via inter


PRIMERA JORNADA MÉDICA ACADÉMICA DE BIENESTAR MATERNO-NEONATAL Y GINECOLÓGICO “HGOIA” ANOMALÍAS PLACENTARIAS, IMPORTANCIA DEL CONTROL ECOGRAFICO PRENATAL: CASO CLÍNICO Md. Santiago Nolasco , Md. Gissela Tashiguano Hospital Gineco-Obstétrico Isidro Ayora INTRODUCCIÓN: Las anomalías de la inserción placentaria como placenta previa y acretismo placentario se asocian con hemorragias durante el segundo trimestre del embarazo; aumentan el riesgo de morbimortalidad materno-fetal en hasta el 7% sin el tratamiento adecuado. Se estima que 1 de cada 200 embarazos presenta placenta previa y 1 de cada 533 acretismo placentario. El principal factor de riesgo es el antecedente quirúrgico: cesárea, legrado, otros; la combinación de cicatriz uterina anterior y la placenta previa aumenta de 10-20 veces el riesgo de acretismo (figura 1). Las complicaciones más frecuentes son la hemorragia grave que requiere transfusiones, histerectomía, coagulación intravascular diseminada, lesión de órganos adyacentes y muerte. OBJETIVO: Exponer la presentación atípica de un caso de placenta previa y percretismo placentario y la importancia de los controles ecográficos prenatales para prevenir y tratar patologías como las anomalías de la implantación placentaria CASO CLINICO: Paciente de 27 años, secundigesta, con antecedente de cesárea anterior, cursa embarazo de 36.2 semanas, niega sangrado, en ecografía obstétrica se evidencia placenta previa oclusiva total con disco placentario mayor ubicado en segmento uterino inferior, ausencia de membrana de Nitabuch. Al Doppler: Hipervascularización úterovesical, subplacentario, vasos puente, lagunas vasculares en su espesor. Grosor placentario de 6 cm, no distinguible adecuadamente la interfaz entre segmento uterino anterior y pared vesical. Placenta acreta índex de 3.5. (figura 2.). Se categorizó como un embarazo de alto riesgo con placenta previa oclusiva total, con signos de acretismo placentario con alto riesgo de percretismo hacia vejiga. Se programó cesárea con equipo multidisciplinario: Ginecologia, Urología, Anestesiología y Unidad de Cuidados Intensivos Maternos (UCIM). Se obtubo el consentimiento informado de la paciente: Si RESULTADOS: Durante la cesárea se evidencia útero gestante, infiltrado con vascularización de grueso calibre, patrón de “cabeza de medusa” que toma toda la pared anterior del uréter, paramétrios, vejiga hacia cérvix y perdida de la anatomía uterina. (figura 3.). Extracción de recién nacido, masculino, APGAR 7-8. Se realiza histerectomía total. Complicaciones: Lesión incidental de uréter izquierdo, reparado en el transquirúrgico por Urología. Sangrado de difícil control por percretismo placentario, que progresa a choque hipovolémico grado IV, el mismo que amerita transfusión masiva, soporte vasoactivo y ventilación mecánica invasiva, permanece en UCIM los primeros 5 días. Paciente permanece 11 días hospitalizada, a su alta médica paciente estable junto con recién nacido. Tablas / gráficos Figura 1. Fuente: PROTOCOLS MEDICINA MATERNOFETAL HOSPITAL CLÍNIC- HOSPITAL SANT JOAN DE DÉU-UNIVERSITAT DE BARCELONA www.medicinafetalbarcelona.org Figura 2. Fuente: Hospital Gineco-Obstétrico Isidro Ayora, Unidad de Diagnostico fetal. Figura 3. Fuente: Elaboración propia. DISCUSIÓN: Las anomalías de la implantación placentaria son la principal causa de hemorragia en el segundo trimestre del embarazo. Los controles ecográficos prenatales recomendados por la guía de práctica clínica del MSP son el 1er control a las 11-14 semanas, 2do a las 18-24 semanas, 3ero a las 30-36 semanas siendo de suma importancia la ecografía del tercer trimestre para el diagnóstico de anomalías placentarias, aunque podemos encontrar signos ecográficos sugestivos desde el primer trimestre de la gestación. La atención prenatal con adecuado seguimiento ecográfico permite determinar el nivel de complejidad del embarazo y derivar oportunamente a centros especializados (tercer nivel) donde se cuenta con el personal experimentado para


POSTER PRESENTATION Open Access Transient dynamics between displaced fixed points: an alternate nonlinear dynamical framework for olfaction Christopher L Buckley*, Thomas Nowotny* From Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011 It is now widely accepted that insects encode odor iden- tity in terms of the stimulus specific rate patterning observed in the projection neurons of the antennal lobe (AL). Several studies have explored nonlinear dynamical frameworks in order to gain general insights into the mechanisms underlying the observed dynamical phenom- ena. The currently most popular framework is the het- eroclinic orbit (HO) developed by Rabinovich and collaborators [1-3]. This framework can account for both the dynamics observed in the locust AL [4] and several desirable computational properties of the AL and the brain in general [2]. Despite its obvious appeal there has been little work on applying the HO framework to more detailed conductance based models of olfactory dynamics even though it is in principle possible to obtain HO dynamics from biologi- cally plausible neurons [5]. However, obtaining proper HO dynamics with conductance based Hodgkin-Huxley neu- rons in this work required non-standard assumptions for the synapses [5]. Furthermore, recent experimental evidence has indicated another possible concern about the original HO interpretation. The HO framework assumes that the presence of an odor re-parameterises the connec- tivity of the AL through input to local neurons (LNs). The mathematical image of this change is a bifurcation from a regime with a single stable fixed point (FP) to a regime with a stable HO. The system approaches the stable HO (or a limit cycle close to it, in the presence of noise) as long as the odor stimulation continues. The HO then loses stability and the system returns to the resting state FP when the odor stimulus subsides. Recent experiments involving long periods of odor stimulation have revealed that the dynamics of the AL appears to settle into a stable fixed point well before the odor subsides [6]. One explana- tion for this observation is the so called heteroclinic chan- nel (HC) introduced in [2] in which the HO ends in a stable FP. Here we describe an alternate nonlinear dynamical fra- mework which provides an appealing account of both the origin and function of rate patterning dynamics. We start by analytically reducing a biologically plausible conduc- tance based model of the AL to a quantitatively equivalent rate model and construct conditions such that the rate dynamics are well described by a single globally stable fixed point. We then straightforwardly describe the AL’s response to an odor stimulus as rich transient trajectories between this stable baseline state and an odor specific fixed point. We show how this framework can account for a disinhibitory period observed immediately after the stimulus is removed, for the qualitative differences between the dynamics in the presence and the absence of odor and for the invariance of odor identity to both the duration and intensity of an odor stimulus, as reported in [7]. We compare and contrast this framework with the popular nonlinear dynamical framework of ‘winnerless competition’ which describes AL dynamics in terms of a HO. Published: 18 July 2011 References 1. Rabinovich M, Huerta R, Laurent G: Neuroscience - Transient dynamics for neural processing. Science 2008, 321(5885):48-50. 2. Rabinovich MI, Huerta R, Varona P, Afraimovich VS: Transient cognitive dynamics, metastability, and decision making. PLOS Comp. Biol 2008, 4(5). 3. Varona , Rabinovich M, Selverston A, Arshavsky Y: Winnerless competition between sensory neurons generates chaos: A possible mechanism for molluscan hunting behavior. Chaos 2002, 12(3):672-677. * Correspondence: c.l.buckley@sussex.ac.uk CCNR, Informatics, University of Sussex, Falmer, BN1 9QJ, UK Buckley and Nowotny BMC Neuroscience 2011, 12(Suppl


9.2 30.4 6.3 5.0 1.0 12.5 17.5 10.0 8.1 Relative importance (calibration-based formulation) [%] Datalogger Calibration uncertainty Non-stability Non-linearity Temperature response Maintenance zero off-set a zero off-set b Directional response EVALUATION OF UNCERTAINTY SOURCES AND PROPAGATION FROM IRRADIANCE SENSORS TO PV YIELD Francesco Mariottini*, Jiang Zhu, Thomas R. Betts, Ralph Gottschalg Centre for Renewable Energy Systems Technology (CREST), Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leicestershire, LE11 3TU, United Kingdom, *Corresponding author: f.mariottini@lboro.ac.uk, +44(0) 01509 635353 AIM HOW (3): directional response and temperature dependency WHY HOW Energy production uncertainty affects financial costs and bankability 1) Reducing uncertainty of (global) irradiance measurements through pyranometers. 2) Assessing impact of reduced expanded uncertainty on the evaluation of PV performance in a solar farm 1) Data quality management 2) almost clear-sky days sampling for uncertainty assessment. 3) Use of calibration data for point- based directional response and temperature dependency of uncertainty. Better understanding and evaluation of systematic and random effects needed. Including (and not limited to): • Physically possible and extreme rare limits (BSRN checks). • Exclusion of days with disconnections checked against sunrise and sunset paths HOW (1): data quality RESULTS SUBJECTS Incoherencies on uncertainty: from 4.7% to 25.3% for solar data but from 3% to 12% on measurements & modelling HOW (2): almost-clear sky days CREST: calibrated ventilated Kipp & Zonen CMP21 pyranometers with Pt-100 temperature sensor COM: fielded pyranometer, CMP21 assumed (datasheet specifications) Relevance of clear sky conditions for energy production and thermal offset in irradiance measurements (ISO 9060) but rare in UK. Almost clear sky days, closest to: • Diffuse fraction of 0.2 • Pearson coefficient r (against Perez’s clear sky model) of 0.95 • Irradiance deviation of 5% Interpolated values (based on calibration certification) filled into the formulation of uncertainty from JCGM 100:2008. Calibration-based formulation reduces relative importance of directional and temperature uncertainties Relative importance: 𝑢𝑖∗𝑐𝑖 𝑢 σ𝑖 𝑢𝑖∗𝑐𝑖 𝑢 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 721452. MAIN CONCLUSIONS By applying a few calibration-based information, irradiance uncertainty is reduced by about 40%. Input data Time resolution [s] Percentage deviation [%] Average expanded uncertainty [W/m2] COM datasheet- based 60 ± 2.87 13.83 3600 ± 3.07 13.83 CREST calibration- based 60 ± 2.01 7.93 3600 ± 2.18 7.94 CREST datasheet- based 60 ± 3.51 13.84 3600 ± 3.79 13.84 Calculation of uncertainty for the 20 selected almost-clear sky days identified between the 3/6/2015 and 3/1/2016. Identification of an almost-clear sky day. Monitored data against calculation through Perez’s model based on Linke Turbidity from Meteonorm and EU project SODA. 6062 6116 6420 6367 6050 6100 6150 6200 6250 6300 6350 6400 6450 Yearly AC energy production (COM datasheet-based) [MWh] Yearly AC energy production (CREST calibration-based) [MWh] Annual energy production (minute average) Effects of uncertainty on estimation of yearly performance (10/8/15- 10/8/16) of a PV solar farm (7389 kWp) based on found deviations. Future independent calibrations will better estimate uncertainty dependency on environmental parameters in irradiance measurements. 70.10 70.69 74.12 73.53 70.00 70.50 71.00 71.50 72.00 72.50 73.00 73.50 74.00 74.50 Performance Ratio (COM datasheet- based) [%] Performance Ratio (CREST calibration- based) [%] Performance Ratio (minute average) Example of identification of “suspect” disconnections against sunrise and sunset paths for a CREST pyranometer. FUTURE STEPS 5.0 18.4 3.8 3.0 15.2 7.6 10.6 6


Assessment of the impact of aerosol from heated tobacco compared with cigarette smoke on experimental rheumatoid arthritis Cintia Scucuglia Heluany1; Pablo Scharf1; Ayda Henriques Schneider2; Paula Barbim Donate2; Fernando Queiroz Cunha2; Sandra Helena Poliselli Farsky1* 1Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil; 2Department of Pharmacology, Faculty of Pharmaceutical Sciences, Ribeirão Preto Medical School, University of São Paulo, Brazil c.heluany@surrey.ac.uk Rheumatoid arthritis (RA) is chronic autoimmune disease which is aggravated in smokers. Alternative modified-risk tobacco products are being developed to provide substitute products for smokers who are unable or unwilling to quit. Among then, heat- not-burn tobacco (HNBT) products generate reduced yields of toxicants compared with cigarettes and hold great potential for reducing the harms associated with tobacco. We aimed to investigate and compare the effects of CS exposure and the aerosol from HNBT on an experimental RA model. Male adults C57BL/6 mice were exposed to air, HNBT or commercial cigarettes in smoking chambers, following the Canada regimen, for 1 hour, twice a day, during the developmental phase of antigen-induced arthritis (AIA), between days 14 to 20. Mice were injected s.c. on day 0 with 500 μg of mBSA in an emulsion of saline and CFA, and boosted on days 7 and 14 with the same preparation in IFA. Intra-articular challenge was carried out on day 21 and after 24 h clinical symptoms were evaluated. Data obtained showed CS-exposed mice presented higher levels of blood carboxihemoglobin, higher articular hyperalgesia and edema, higher amount of NETs and MCP-1 in the synovia and higher number of granulocytes in the bone marrow than their counterparts. HNBT-exposed mice presented similar picture of the disease than air-exposed mice, except by reduced influx of cells in the synovial fluid. Nevertheless, such CS or HNBT exposures reduced the amount of IL-10 in the synovia and number of splenocytes and cells in the DLNs. Moreover, CS delivered higher amounts of toxic metals into exposure chambers, and lungs of CS-exposed mice showed higher histopathological score than other groups. Our data highlight HNBT exposure does not worse the local and systemic AIA symptomatology as CS exposure does, providing novel evidence surrounding the HNBT as a possible alternative to reduce the smoking-related health risks, mainly in chronic diseases. CONCLUSION METHODS Financial support Financial support: *Ethics Local Committee (Protocol CEUA/FCF -USP #563) Male C57BL/6 mice were exposed, 1 hour, 2 times/day, using a smoking chamber, to synthetic air (control) or heated tobacco (48 Heatsticks/day) or commercial cigarettes (24 cigarettes/day) during the developmental phase of antigen-induced arthritis (AIA), as shown in the scheme below. On day 21, mice were challenged by i.a injection of mBSA (30 µg) into the knee joint and after 24h, animals were euthanized and clinical parameters were assessed. Day 0 Day 7 Day 14 Day 21 Booster mBSA + IFA s.c. Booster mBSA + IFA s.c Immunization mBSA + CFA Intra-articular challenge + 24h: Euthanasia Day 20 Air Heated tobacco Cigarette smoke 1 hour (2x/day) (between days 14-20) AIM Investigate and compare the effects of cigarette smoke exposure and the aerosol from heated tobacco on an experimental rheumatoid arthritis (RA) model. Cigarette smoke (CS): major environmental risk factor involved with the induction and aggravation of rheumatoid arthritis (RA) Alternative modified-risk tobacco products are being developed to provide substitute products for smokers who are unable or unwilling to quit. Among then: heat-not-burn tobacco products generate reduced yields of toxicants compared with cigarettes and hold great potential for reducing the harms associated with cigarette use. RESULTS INTRODUCTION 2) CS increased the neutrophil influx into the joints and the product


Product Deﬁnition Technology Develop- ment Quality Manage- ment Risk & Safety Assessment Regulatory Support Upscaling Sustain- ability Training Marketing Product Develop- ment PHOENIX project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 953110. OUR TEAM The PHOENIX team consists of 12 international partners distributed across 6 coun- tries. The partners are from the following countries: Austria, Croatia, Germany, Lux- embourg, Netherlands and Spain. All partners contribute actively to the project to establish the service portfolio of PHOENIX to cover the whole supply chain leading to GMP manufacturing of nanopharmaceuticals. 4 PHOENIX-OITB SERVICE PORTFOLIO The PHOENIX-OITB service portfolio is divided into 5 different categories. Each category includes a list of services, all of which together cover the different topics needed for the development of nano-pharmaceuticals from early stage to entry into clinical trials. 1 HOW IT WORKS PHOENIX concept & service strategies PHOENIX offers solutions to overcome the biggest hurdle in the translation process of most nano-pharmaceuticals – the so-called “innovation valley of death”. To learn more visit: www.phoenix-oitb.eu GET IN TOUCH info@phoenix-oitb.eu PHOENIX-OITB – A single entry point to develop and upgrade innovative nanopharmaceuticals The Single Entry Point of the PHOENIX-OITB provides access to a consolidated net- work of facilities, technologies, services and expertise for all technology trans- fer aspects from characterization, testing, verification up to scale up, GMP compliant manufacturing and regulatory guidance. The OITB services include production and characterisation under GMP con- ditions, safety evaluation, regula- tory compliance and commercia- lisation boost. METHODS The PHOENIX-OITB has been structurally conceived, designed and officially registered under the legal non-profit company, PHOENIX gGmbH. To test the operative capacity of PHOENIX-OITB, five demo-cases of different NP types, manufacturing methods and administration routes will be employed. Additionally, two pro bono demo-cases will be launched and granted to external users to test the services at relevant and operational environment. ABSTRACT The PHOENIX Open Innovation Test Bed (PHOENIX-OITB) is focused on overcoming the challenges of production of novel and innovative nanopharmaceuticals (NPs) from lab scale to GMP quality and production, maximising bioavailability, stability and manufacturing to allow their implementation in the medicine field. PHOENIX-OITB is a non-profit, open and self-sustaining legal entity that works as a Single-Entry-Point (SEP) providing its end-users transparent processes and proce- dures as well as easy access to services and expertise needed to bridge the gap bet- ween the bench and the bedside, i.e., providing them with high-quality services, capable of Quality-Efficacy and Safety (QES) evaluation and production of nanophar- maceuticals at large scales, meeting the regulatory and GMP requirements. RESULTS Process transfer and method development for all five demo-cases are ongoing while GMP production area is being constructed. The Pharmaceutical Quality Management System (PQMS) is being established and all exploitation activities are being managed and can be seen through: www.phoenix-oitb.eu. Furthermore, PHOENIX-OITB Open Call for the granting of two pro bono demo-cases to external end-users has been launched and applications are under evaluation. Johanna K. Scheper,1,12,* Alba Cordoba,2 Ariadna Padrós,3 Nora Ventosa,4 Jesus M. De la Fuente,4 Ivana Vinković Vrček,5 Hannes Bauer,6 Mangala Srinivas,7 Sabine Fleischer,8 Robert Holzer,9 Tommaso Serchi,10 Nazende Günday-Türeli11 1 BioNanoNet Forschungsgesellschaft mbH, Graz, Austria, 2 Nanomol Technologies S.L, Barcelona, Spain, 3 Leanbio S.L, Barcelona, Spain, 4 Consejo Superior de Investigaciones Cientificas (CSIC), Spain, 5 Ins- titute for Medical R


Human Structural Connectomes are Heritable Jaewon Chung 1 Benjamin D. Pedigo 1 Carey E. Priebe 2 Joshua T. Vogelstein 1 1Department of Biomedical Engineering, Johns Hopkins University 2Department of Applied Mathematics and Statistics, Johns Hopkins University Summary Understanding how brain connectivity is influenced by genetics can improve our understanding of brain function and diseases. Existing methods ignore spatial arrangement of the brain or are not statistically justified. Our random graph theory and statistical approach enable formulation and testing of different models of connectome heritability. We show that brain connectivity is more similar in monozygotic twins compared to those of dizigotic twins and siblings. Other frameworks (e.g. joint graph embeddings) can be used for vertex level analysis. Data and Preprocessing Human Connectome Project Young Adult study (HCP1200) [4]. Zygosity Monozygotic Dizygotic Non-Twin siblings N 250 259 476 Sex 167 F, 83 M 140 F, 119 M 223 F, 248 M Age 29.6 (3.3) 28.9 (3.4) 28.3 (3.9) Age range 22-36 22-36 22-37 Table 1. HCP 1200 Participants and their demographics Figure 1. Outline of the ndmg (https://ndmg.neurodata.io) pipeline. Image taken from [2]. Estimating Heritability Figure 2. Outline of heritability estimation process. For semiparametric testing, we consider the three test cases: Equality up to rotation: H0 : X = WY against Ha : X ̸= WY where W ∈Rn×n and WW T = I Equality up to scaling: H0 : X = cWY for some c > 0 against Ha : X ̸= cWY for any c > 0 Equality up to diagonal transformation: H0 : X = DWY for some diagonal D against Ha : X ̸= WDY for any D Two-Sample Semiparametric Test Results Figure 3. Kernel density estimates (KDEs) of the test statistics is shown on the left column, and the empirical cumulative distribution (eCDF) of associated p-value give by null-distribution is shown on the right column. 1. Kernel density estimates (KDEs) for monozygotic twins is different from those of dizygotic twins, sibling, and unrelated. 2. Distribution of test statistics for monozygotic twins is more positively skewed compared to others. 3. Empirical cumulative distribution function (eCDF) for monozygotic twins is more concentrated near 1 compared to others. 4. This empirical finding is validated through six statistical models and tested via two sample Kolmogrov-Smirnoff test (Table 2 and 3). Two-Sample Kolmogrov-Smirnov (KS) Test Results Null hypothesis is that the two samples are drawn from the same distribution. Alternate Hypothesis Test Cases Rotation Scalar Diagonal Monozygotic < Dizygotic < .001 *** < .001 *** < .001 *** Monozygotic < Sibling < .001 *** < .001 *** < .001 *** Monozygotic < Unrelated < .001 *** < .001 *** < .001 *** Dizygotic ̸= Sibling 0.353 0.337 0.750 Dizygotic ̸= Unrelated 0.009 ** 0.009 ** 0.169 Sibling ̸= Unrelated < .001 *** < .001 *** 0.100 Table 2. P-values for KS tests on distributions of test statistics from semiparametric tests. Alternate Hypothesis Test Cases Rotation Scalar Diagonal Monozygotic > Dizygotic < .001 *** < .001 *** 0.0012 ** Monozygotic > Sibling < .001 *** < .001 *** < .001 *** Monozygotic > Unrelated < .001 *** < .001 *** < .001 *** Dizygotic ̸= Sibling 0.120 0.109 0.199 Dizygotic ̸= Unrelated < .001 *** < .001 *** 0.154 Sibling ̸=Unrelated < .001 *** < .001 *** 0.025 * Table 3. P-values for KS tests on distributions of p-values from semiparametric tests. Significance levels are marked with * (p < .05), ** (p < .01), and *** (p < .001). What's Next? 1. Vertex importance - which vertex confers the most heritability? 2. Edge importance - which edges are important? Code and Data Allanalysiswasperformedusinganopen-sourcepackageGrasPy(https://graspy.neu- rodata.io). AlldMRIimagesareopen-sourceandprovidedbytheHumanConnectome Project (https://www.humanconnectome.org/study/hcp-young-adult/overview). References [1] Avanti Athreya, Donniell E. Fishkind, Minh Tang, Carey E. Priebe, Youngser Park, Joshua T. Vogelstein, Keith Levin, Vince Lyzin


The Order of the Octopus Macy Huston1,2 & Sofia Sheikh3 1Penn State Astronomy & Astrophysics, 2Penn State Extraterrestrial Intelligence Center, 3SETI Institute Who We Are The Order of the Octopus is a community of early-career researchers doing technosignature-related work. The group was founded by Dr. Sofia Sheikh in March 2020, to offset some of the specific difficulties in getting into SETI research, which were only exacerbated by the COVID-19 pandemic. Early-career researchers in SETI not only have to face the standard challenges of pursuing a degree or research project in STEM, but also must contend with uncertain federal funding, discouraging comments from researchers who are SETI skeptics, and often being the only person at an institution who is both early-career and pursuing technosignature science. This lack of support, evidenced in the preceding ways and in others, is uniquely challenging, and having a community to provide guidance is particularly important. Thus, the Order of the Octopus was founded to combat these challenges. The Order’s name comes from the “Order of the Dolphin,” a name adopted by attendees of the first SETI conference in Green Bank, WV in the 1960s. The members were enthralled by John Lilly’s presentation about the potential for understanding extraterrestrial languages through studying dolphin communication. The quirkiness of the name and its connection to the history of SETI research led us to adopt the name for this event. We quickly learned, however, that John Lilly’s research included unethical practices, and we did not want to keep the name due to that historic harm. To retain the camaraderie and wonder for non-human intelligences that the original name meant to us, we adopted “The Order of the Octopus,” divorcing ourselves from the dark history of the association with dolphins, and recognizing a perhaps even more interesting model for non-human intelligence on Earth! The Order of the Octopus currently manifests in a few different ways: 1) An online forum (currently on the Discord platform) with over 20 current members, hosting conversations about research, conferences, grants, and other opportunities 2) A conference organized by the group and supported by the PSETI Center: The 2021 Assembly of the Order of the Octopus (described below), with the intention of hosting similar events in the future 3) In-person meetups at other conferences, such as the 2022 PSETI Symposium. Members Our group is made up of about 22 early career researchers in SETI. Here we feature 6 members who are attending the SETI Symposium: The 2021 Assembly of the Order of the Octopus In the Summer of 2021, the OotO held a virtual conference for early-career researchers in SETI. The organizing committee members were Dr. Sofia Sheikh, Macy Huston, Nick Tusay, Tessa Fisher, and Evan Sneed, and the event was sponsored by the Penn State Extraterrestrial Intelligence Center. Our goal was to to provide networking and community-building for early-career folks in SETI by providing a venue for participants to present talks and posters, perhaps even their first talks and posters, in a safe and supportive environment. Dr. Sofia Sheikh is an NSF-ASCEND Postdoctoral Fellow working on radio technosignature searches with the Allen Telescope Array through the SETI Institute. She founded OotO in Spring 2020, and is thrilled to see how much the community has grown since! George Profitiliotis is a Postdoctoral Researcher within the Department of Humanities, Social Sciences, and Law of the National Technical University of Athens, Greece, investigating the pertinence of anticipation to the search for extraterrestrial life; he is mainly interested in the science-policy-society interface of the search, including technosignatures, and particularly in using insights from futures studies and prospective cognition to inform the governance of the search. Tessa Fisher's research includes investigating if atmospheric chemical reaction network topology c


• V1.0 was released in 2009 • SQUAM analyzes bias of global satellite L2/L3 SSTs w.r.t. 2 types of reference SSTs - (1) in situ (from the NOAA iQuam system) ; and (2) global gap-free L4 SST analyses. - L4 analyses offer global coverage (“instantaneous look”) and greater uniformity in space & time - The global distributions of the ΔTs are expected to be centered at ~0 and close to Gaussian • Plots: Maps, Histograms, Time Series, Dependencies, and Hovmöller Diagrams • SQUAM is a GHRSST resource for near real-time monitoring and validation of major global satellite & blended SST products produced by the SST community • Updated to V2.0 in 2017 - Focus on NOAA & partners products (can add other products by data users/ producers request) - Polar page: Selection of ACSPO VIIRS, ACSPO AVHRR GAC, and AVHRR FRAC (ACSPO & OSI SAF) - New Geo page created: H08 AHI; option to display vs. GMT and Local Time - L4 page: reduced list of products (NOAA partners; most informative for SQUAM analyses) - New features: SSES bias correction, time aggregation, etc. - Interface redesign • Replaced the ACSPO development products with operational products • NOAA-20 provisioned (pending ACSPO 2.50 operational deployment) • Added ACSPO G16 ABI; G17 ABI provisioned (currently disabled) • Full line of ACSPO L3U provisioned (pending ACSPO 2.50 operational deployment) SQUAM Background Structure (Newly added) Geo: G16 1. NOAA/NESDIS/STAR 2. Global Science and Technology, Inc 3.Colorado State University/CIRA Kai He1,2, Xinjia Zhou1,3, Sasha Ignatov1, Olafur Jonasson1,2 Update to SST Quality Monitor (SQUAM) Polar: GAC L2P vs. L3U Comparison between Metop-A GAC L2P and L3U • Global statistics are comparable between L2P and L3U GHRSST XIX Meeting, Darmstadt, Germany, 4 - 8 June 2018 SQUAM v2.1: https://www.star.nesdis.noaa.gov/sod/sst/squam/ What’s new in v2.1 Polar L2/L3 Geo L2/L3 Analysis L4 High Resolution S-NPP VIIRS (N20 coming soon) ACSPO L2P/L3U AVHRR FRAC ACSPO L2P OSISAF L2P H08 AHI ACSPO L2P/L3U G16 ABI ACSPO L2P/L3U MUR (JPL) Low Resolution AVHRR GAC ACSPO OPR L2P ACSPO RAN L2P/L3U CMC (Environment Canada) OSTIA (Met Office) OSTIA RAN (Met Office) GMPE (Met Office) Geo Polar Blended (NOAA) Reynolds (NOAA) GAMSSA (BoM) • Operational product (ACSPO 2.50) • L2P/3U - Subsampled to 1 image per hour - Planning to move to L2C/3C (hourly collated) • UTC based (default) - For monitoring sensor performance • Local solar time based - For scientific analysis, such as diurnal cycle effect G16 ABI: L2P vs. L3U • Mean and SD Statistics of (ABI SST – CMC) are comparable between L2P and L3U L4 Analyses L4 SSTs: CMC, OSTIA, GMPE, Reynolds, GAMSSA, MUR, OSTIA RAN, GPB • Added by Request of the NOAA Coral Reef Watch Team • OSTIA Reanalysis (RAN): Jan 1985 – Dec 2007 • NOAA Geo-Polar Blended (GPB): Sep 2002 - present SD(L4 SST – in situ) Summary • SQUAM v2.1 has been expanded to include several new products • Only operational products are now displayed in SQUAM • Back-end processing has been rewritten and highly optimized • Data access page is added Future work - ACSPO G16 ABI - A consistent line of L3U - OSTIA RAN and GPB L4 - G17 and N20 buttons provisioned Alex.Ignatov@noaa.gov Acknowledgments • This work is supported by the JPSS and GOES-R Program Offices, and the NOAA Ocean Remote Sensing (ORS) Program. • The views, opinions, and findings in this report are those of the authors and should not be construed as an official NOAA or U.S. government position or policy Night L3U SD(SST – CMC), day SD(SST – in situ), day SD(SST – CMC), night SD(SST – in situ), night Day L3U Night L2P Day L2P Mean(SST – CMC) SD(SST – CMC) G16 ABI: L2C & L3C • SD reduced by up to ~0.3K (in RMS sense) in L2C/3C • NOBS and clear-sky ratio remarkably boosted (~2M more valid SSTs) Mean(SST – CMC) SD(SST – CMC) Matchup(SST – CMC) Clear%(SST – CMC) - Add N20 VIIRS and G17 ABI - Two ACSPO lines: OPR + RAN - For ABI/AHI, switch from L2P/3U to L2/3C - Add Metop-C SST when launched in Sep 2018


Cryogenic system deployed at TUM's (Munich, Germany) shallow underground laboratory Source Ambient Gammas 3.937 Atmospheric Muons 0.019/1.4 0.0134/5 Flux [s-1 cm -2] Atmospheric Neutrons (dominant after vetoing) Searching for Coherent Elastic Neutrino-Nucleus Scattering (CEvNS) with the NUCLEUS detectors Author: Marco Giammei on behalf of the NUCLEUS collaboration Marco Giammei - Ph.D. Candidate - Università di Roma "Tor Vergata" - marco.giammei@roma2.infn.it Coherent Elastic Neutrino Nucleus Scattering (CEvNS) The Experimental Site: VNS at Chooz Nuclear Power Plant Sensitivity and Simulations Interesting Measurements and future plans Active Vetos and Shielding Cryogenic Target Detectors Cryogenic System Very Near Site (VNS): - 24 m2 basement room (~3 m.w.e. overburden) - 30% Muon Attenuation, factor 5 neutron attenuation - Two 4.25 GWth reactors - Anti-Neutrino Flux: ɸ𝜈=1.7×1012 𝜈/cm/s A precision measurement of the CEvNS cross-section oﬀers a unique way to study many neutrino properties and to search for new physics beyond the Standard Model. Direct calibration of nuclear recoils - Neutron absorption followed by de-excitation with high energy 𝛾 emission and nuclear recoil. - Nuclear recoil on CaWO4 expected at 112 eV - Seen with 3σ signiﬁcance using 55Fe calibration Known Backgrounds: - Expected CEvNS rate: • ~30 counts/kg/day in the 10eV-1keV recoil energy range - Targeted Signal/Background ≥ 1 - With 100 dru ﬂat background and full setup: • 5σ signiﬁcance in few weeks of live-time • 10% uncertainty on CEvNS Inner Veto: - Instrumented holder for target detectors: • Sub-keV cryogenic detector with TES readout - Vetos against • Mechanical stress events • "EXCESS" • Surface contamination Muon Veto (MV) : - 5 cm thick plastic scintillator plates - SiPMs & WLS-ﬁber readout - 4π coverage with cryogenic muon veto - Threshold ~ 5 MeV External Shielding: - Lead and Polyethylene Inner Shielding: - Lead, Copper, PE, B4C - Shielding against neutrons and ambient gammas Cryogenic Outer Veto (COV): - Active ionization detectors - Reduction of external ɣ - 4 kg of 2.5 cm thickness in 6 HPGe crystals (4π coverage) - Threshold <10 keV Unknown Background "Low energy EXCESS": - Unexplained exponential rise of counting rate at low energies (similar to reactor CEvNS) - With "EXCESS" competitive limits can be set on new physics models (light mediators or neutrino EM properties) NUCLEUS status and future developments: - Experimental setup being deployed at TUM (Munich, Germany) in shallow underground laboratory for ﬁnal testing and background validation - 2025: setup deployment at Chooz Neutrino Energy Weak Charge Nuclear Form- Factor "Dry" Dilution refrigerator to avoid handling of cryogenic liquids. The base temperature reached is below 7mK. Model: BlueFors LD400 cryogen-free dilution refrigerator Cooling Power: >500 μW at 100mK ✓ Custom Vibration decoupling system deployed and in use (patent protected) ○ Installation of read-out electronics under commissioning ○ Installation of calibration electronics under commissioning Gram-scale cryogenic calorimeters equipped with thin-ﬁlm tungsten transition-edge sensors as highly sensitive thermometers. Optimized to measure energies under a few keV. Two 3x3 matrices of target detectors. Multi-target approach: - Al2O3: for background measurement - CaWO4: high CEvNS rate Transition-Edge Sensor (TES): superconductive ﬁlm operated on the onset of the transition (operated at ~10mK) First combined operation of vetos with target detectors - Muon Veto + One COV crystal + One Al2O3+TES crystal cube - For ~40h of data expected 3-fold coincidences in low background environment (~15 m.w.e): • few direct muons and accidentals (very few in CEvNS's R.O.I) Absorber crystal cube coupled with Source Sum Preliminary 25.8±2.2 55.4±2.1 311.8±9.4 Ambient 𝛾s 3.937 0.019/1.4 0.0134/5.0 (sum) < 1.2 < 7.9 20.9±0.6 0.91±0.18 3.2±1.3 <3.6 39.4±0.9 11.47±0.65 51.4±8.4 10.5±3.5 116.1±1.5 133.8±2.21 Atmospheric muons Atmospheric neutro


NAMA : IRMAWATI NIM : 90100121074 KELAS : EKIS .C TUGAS : PKN A. Contoh pelanggaran sila ketiga 1. Bersikap egois dan ingin menag sendiri


Technology is Fun, i promise Below I will highlight the importance of technological developement in South Africa. Yes, you read that right! Just recently news broke out that Microsoft cloud services are expanding its data centers in South Africa (Microsoft News Center, 2022). This is great for South Africa because not only is it growing the tech industry it's also creating job opportunities and people to be able to see tech close by and not something of first world countries. The tech industry is growing in South africa To get an idea on how important and beneficial technology could be for South Africa here are a few pointers: It could help with enhancing and creating better systems in the departments of South Africa. For example integrating technology in the department of health. It could help better the data capturing in public hospitals and clinic which would help by sending SMS's informing them that their medication is ready for collection or informing them about peak and off-peak hours in the hospital. Another point could be technology helping the country become a safer country. For example the police force being able to get their hands on the top of the range GPS systems where they could be able to track the crime hotspots in the countries and be able to patrol that area. What could technology do for south africa ? WE ALMOST THERE... Software Engineer Software Developer Data Engineer Data Scientist Data Analyst Web Developer Computer Engineer Technical Support Cybersecurity Engineer The different jobs you can get in tech: In the tech industry the pay can range from +- R29 000 to +- R100 00 per month (BusinessTechSA, 2022). OK THE EXICTING PART Reference list BusinessTechSA (2022). The most in-demand tech jobs for South Africans right now – including pay. [online] Businesstech.co.za. Available at: https://businesstech.co.za/news/technology/578586/most-in- demand-tech-jobs-for-south-africans-right-now-including-pay/ [Accessed 23 Aug. 2023]. Microsoft News Center (2022). Microsoft expands cloud services in South African data centres to drive growth and competitiveness – Middle East & Africa News Center. [online] news.microsoft.com. Available at: https://news.microsoft.com/en- xm/2022/11/01/microsoft-expands-cloud-services-in-south-african- data-centres-to-drive-growth-and-competitiveness/ [Accessed 23 Aug. 2023]. Van Wyk, C. (2012). SURVEY OF ICT IN SCHOOLS IN SOUTH- AFRICA ___________________________________________________________________________ Public Expenditure Analysis for the Department of Basic Education: Report 8. [online] Available at: https://www.education.gov.za/Portals/0/Documents/Reports/Resea rch%20Repository/LTSM/Survey%20of%20ICT%20in%20schools%2 0in%20SA.pdf?ver=2019-09-09-102208-963 [Accessed 23 Aug. 2023]. The education system in South Africa requires improvement but the Department of Basic Education has been trying to implement ICT in schools as a subject. But the only thing hindering their efforts is that there are not enough public schools in SA that have access to working computers (Van Wyk, 2012). This could be an issue that could easily solved if schools had the help of big corporate companies that would be able to donate computers to schools or sponsor schools. The fact that the issue is acknowledged is a step in the right direction. Information & communications Technology Keep That Gold Shining jcp@keepthatgoldshining.org www.keepthatgoldshining.org 39 Block PP1 Soshanguve, 0152


Detangling the mystery of the intriguing odor of dermatophytes Lenka Machova1,2, Michaela Svarcova1,2, Andrej Jasica1,2, Sandra Awokunle Holla1,2, Alena Grasserova2,3, Jaroslav Semerad2,3, Adela Cmokova2, Vit Hubka2, Miroslav Kolarik2 References 1. Weitzman, I., & Summerbell, R. C. (1995). The dermatophytes. Clinical Microbiology Reviews, 8(2), 240–259. 2. Semerád, J., Moeder, M., Filip, J., Pivokonský, M., Filipová, A., & Cajthaml, T. (2019). Oxidative stress in microbes after exposure to iron nanoparticles: analysis of aldehydes as oxidative damage products of lipids and proteins. Environmental Science and Pollution Research, 26(32), 33670–33682. https://doi.org/10.1007/s11356-019-06370-w. First volatome analysis of dermatophytes shows unique spectra of volatile organic compounds found in isolates of human mycoses. • Dermatophytes = common fungal skin pathogens of mammals, producing variety of secondary metabolites 1 • Volatile organic compounds (VOCs) = a group of secondary metabolites 1. Introduction Fig. 1 (a) classic cultivation of the dermatophyte; (b) cultivation of dermatophytes with sheep wool in vial; (c) analysing of the sample with Gas-Chromatography Mass Spectrometry; (d) prediction of molecular structure • cultivation →SPME/GC-MS →prediction of molecular structure (Fig. 1) 2 • Spectra specific for isolates • Molecular biology – comparison of phylogeny with chemotaxonomy 2. Methods • 40 strains, 15 taxa = 80 identified features • terpenoids, ethers, aromatic compounds, compounds with sulphur, anisols, amines etc. • compounds specific for dermatophytic group • in one case, the compound was specific for a species • terbinafine resistants cluster separately from non-resistants • phylogeny and chemotaxonomy are not consistent 3. Results • We propose selected compounds as putative markers of dermatophyte infection (for future application of electronic nose etc). • A new approach for distinguishing between dermatophytic species and terbinafine resistant species. 4. Discussion Fig. 2 (a) PCA of strains divided by the species - E. floccosum (EF), M. canis (MC), N. gypsea (NG), T. benhamiae var. benhamiae (TB), T. erinacei (TER), T. europaeum (TEUR), T. interdigitale (TI), T. indotineae (TIND), T. japonicum (TJ), T. benhamiae var. luteum (TL), T. persicum (TP), T. quinckeanum (TQ), T. rubrum, (TR),T. tonsurans (TT), T. verrucosum (TV).; (b) occurrence of detected VOCs in all dermatophyte and non- dermatophyte species; (c) Agglomerative hierarchical clustering of the representatives of resistant and non- resistant strains; TR = T. rubrum, TRR = T. rubrum resistant to terbinafine, TI = T. interdigitale, TIND = T. indotineae; (d) Multilocus tree of the ITS, tubb and tef1α loci (on left), Agglomerative hierarchical clustering by the Ward’s method with the Euclidean distances (on right) Contact me. Msc. Lenka Machova Msc. Michaela Svarcova Lenka.machovka@seznam.cz Svarcova.michaela92@gmail.com Laboratory of fungal genetics and metabolism - IM CAS (a) (b) (c) (d) 1Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vinicna 5, 128 44, Prague 2, Czech Republic 2Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic 3Institute for Environmental Studies, Faculty of Science, Charles University in Prague, Benatska 2, 128 01, Prague 2, Czech Republic (a) (b) (c) (d) This research also benefitted from funding by the European Union’s Horizon 2020 research and innovation program (RISE) under the Marie Skłodowska-Curie grant agreement No. 101008129, project acronym “Mycobiomics”


W. VOGT-KAUTE, S. FITTJE Naturland e.V., Kleinhaderner Weg 1, 82166 Gräfelfing w.vogt-kaute@naturland.de, www.naturland.de ECOBREED project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 771367. The content of this paper reflects only the author‘s view and the European Union Agency is not responsible for any use that may be made of the information it contains. Kältetoleranz von Soja in Feld und Klimakammer Abbildung 1: Korrelation des Feldaufganges der Jahre 2022 und 2023, sowie Feldaufgang 2022 mit Klimakammerversuchen 2022 1 1 2 2 3 3 Einleitung und Zielsetzung Kältetoleranz ist ein wichtiges Merkmal in der Züchtung von Soja für den Anbau in Europa (V. Hahn, 2019), wenn in weiter nördlich gelegenen Regionen Sojabohnen angebaut werden sollen. Dabei ist Kaltetoleranz während der Keimung, der Jugendentwicklung und während der Blüte relevant. Im Projekt ECOBREED wurden Sorten der beteiligten Züchter und bekannte zugelassene Sorten auf die Kältetoleranz während der Keimung und der Blüte verglichen. Methoden In Dittlofsroda, einem klimatischen Grenzstandort mit lehmigem Sand, wurden 40 Sojasorten zu 3 Saatzeitpunkten über 2 Jahre Mitte April, Anfang Mai und Mitte Mai in einer randomisierten Blockanlage in 3 Wiederholungen angebaut. Die Sommermonate beider Jahre waren sehr warm und trocken. 2022 wurden alle Sorten zusätzlich einem Test in einer Klimakammer unterzogen. Das Saatgut wurde oberflächlich sterilisiert und in Petrischalen mit feuchtem Filterpapier plaziert (20 Körner). Nach 15-stündiger Quellzeit verblieb die Kontrolle bei Zimmertemperatur, während eine weitere Schale für 7 Tage in einer Klimakammer bei 6°C lagerte. Die Keimung wurde 24 Stunden und 5 Tage nach Auslagerung der Schalen bonitiert. Ergebnisse und Diskussion Die alte Sorte Strengs Weihenstephaner (1) zeigte in beiden Jahren im Feld mit 23 und 60% die besten Ergebnisse (Abb.1). Im Jahr 2022 schnitten zur Bonitur zudem Paprika, GL Susanna (2), Sonali (3) (19%) und Salsa (18%) vergleichsweise gut ab. Im Jahr 2023 liefen Sonali (56%) und EZG 22655 (52%) am besten auf. Xonia und Altona zeigten in beiden Jahren sehr geringe Feldaufgänge (2-4%), neben Merlin und Xena, bei denen sie nur in einem Jahr sehr niedrig waren. In beiden Jahren reiften die Bestände gut ab, 2022 schon bis Anfang September. In beiden Jahren war der Feldaufgang beim zweiten und dritten Aussaatterminen deutlich niedriger, 2023 bei nahezu null. Das in der Klimakammer gelagerte Saatgut keimte während der Kältephase nicht. Die meisten Sorten trieben nach Auslagerung jedoch noch aus. 24 Stunden nach Auslagerung waren 8 Sorten schon zu mindestens 80% gekeimt (Mittel: 44%) und nach 5 Tagen waren 16 Sorten zu mindestens 90% gekeimt (Mittel: 71%). GL Susanna, Caloria and Kristian schnitten sowohl im Feld als auch in der Klimakammer vergleichsweise gut ab. Nicht alle Sorten zeigten gleiche Reaktionen im Feld und in der Klimakammer (Abb.2). Strengs Weihenstephaner, Alicia und VM 18.184 waren besser im Feld, während 19177012, Lenka und Angelica besser in der Klimakammer abschnitten. Schlußfolgerungen Es konnten Sortenunterschiede festgestellt werden. Die Sorten Strengs Weihenstephaner, GL Susanna und Sonali fielen wiederholt besonders positiv auf. Bei Frühjahrstrockenheit können späte Aussaaten ein Risiko auf diesem Standort darstellen. Klimakammerversuche zeigten, dass die meisten Genotypen auch nach Quellung kurzfristig kalte Temperaturen tolerieren können und danach weiter austreiben. Danksagung Wir bedanken uns herzlich bei Herrn Dr. Schweizer und Frau Dr. Schwertfirm (Inst. f. Pflanzenbau u. Pflanzenzüchtung 1b, LfL Freising) für die Durchführung der Versuche in der Klimakammer. Literatur Hahn V., Schmid K., Vögele R. & Balko C. (2019) Genomik-basierte Verbesserung des heimischen Sojazuchtmaterials und Etablierung eines molekularen Screeningsystems für Soja-Pathogene. Abschlussbericht, online verfügbar unter https://orgprints.org/i


Toothed Aquatic Baleen Aquatic BM1 BMS OU1 OUM OUMV OUMA OUMVA Afrotheria 0.00 0.03 0.00 0.00 0.29 0.00 0.44 Artiodactyla 0.00 0.00 0.00 0.09 0.31 0.23 0.13 Caniformia [- Lutrinae] 0.02 0.15 0.01 0.04 0.34 0.02 0.41 Musteloidea 0.15 0.27 0.06 0.04 0.06 0.12 0.21 1. Introduction Most mammal species live on land, but the largest mammals live in the oceans. Aquatic and terrestrial habitats clearly impose differing selective pressures on body size. However, the quantitative study of body size evolution in mammals and other major animal clades typically focuses on either terrestrial or marine clades independently, thus failing to capture the dynamics of size evolution associated with the transition between land and water. Consequently, the extent to which the rate, magnitude, and outcome of size change associated with habitat transitions are shared among clades remains unknown, leaving open the question of whether the apparently common phenomenon of size increase associated with the acquisition of an aquatic lifestyle reflects idiosyncratic responses of individual clades versus a common response to universal constraints. The evolution of aquatic mammals toward a nearly universal large size? Evidence from phylogenetics and fossils 2. Materials and Methods William Gearty1,*, Craig R. McClain2, and Jonathan L. Payne1 1Department of Geological Sciences, Stanford University; 2Louisiana Universities Marine Consortium *wgearty@stanford.edu 3. Results 4. Conclusions • 3 out of 4 mammal groups living in aquatic environments have larger optimal body sizes than their terrestrial counterparts. • Results suggest the existence of a body size attractor (~500 kg) that has been discovered independently by these three aquatic clades, coupled with shared relatively rapid selection toward, and limited deviation from, this attractor (not shown here). • Some groups may still be getting larger, although analyses suggest there may be an upper limit without help from key innovations (e.g. baleen). • The sustained small size of aquatic mustelids could indicate the presence of a second attractor at a smaller size or competitive exclusion from the 500 kg attractor. • Analyses of the fossil record find indistinguishable optima (with large error), but produce different model support. References Beaulieu JM, et al. Evolution. 2012 Aug;66(8):2369–83. Bininda-Emonds ORP, et al. Nature. 2007 Mar 29;446(7135):507–12. Butler M, King A. Am Nat. 2004;164(6):683–95. Fortelius M. New and Old Worlds Database of Fossil Mammals. 2015. Heim NA, et al. Science. 2015 Feb 20;347(6224):867–70. Hunt G. Paleobiology. 2006 Dec;32(4):578–601. Jones KE, et al. PanTHERIA. Ecology. 2009 Sep 17;90(9):2648–2648. Smith FA, et al. MOM. Ecology. 2003 Dec 11;84(12):3403. The Global Biodiversity Information Facility. 2015. (gbif.org) Tomiya S. Am Nat. 2013 Dec 14;182(6):E196–214. Silhouettes from phylopic.org Figure 3.2: Comparison of results of phylogenetic and fossil analyses. Overlay of Ornstein-Uhlenbeck processes using average parameters as estimated by OUwie phylogenetic and paleoTS fossil analyses for individual clades. Points and error bars within paleoTS results represent average raw data and variance, respectively, per Myr time bin. Error bars associated with the OUwie curve origins indicate the extents of branches associated with aquatic transitions. Note the differences between the results of the phylogenetic and fossil analyses of Sirenia and Pinnipedia. General Equation of an OU Model: 𝒅𝑿𝒕= 𝜶𝜽−𝑳(𝒕) 𝒅𝒕+ 𝝈𝒅𝑩(𝒕) 𝐿(𝑡): initial body size 𝛂: strength of selection 𝑑𝑋𝑡: change in body size 𝛔: intensity of random drift 𝑑𝐵(𝑡): random variation 𝛉: body size optimum Session 163—Booth #308 Figure 2.1: Habitat reconstruction for the four clades of interest. Tip and node labels indicate terrestrial, toothed aquatic, and baleen aquatic species. Figure 3.1: Body size optima. Model-averaged median optima (θ) as estimated by OUwie analyses (circles) and mean modern body sizes (triangles) separated


SciPy 2024, Tacoma, WA Workflow scalable pythonic likelihood fitting Errors Minimize Model Data Loss Loss Simultaneous Constraints Minimization Fit result Fitting something more complicated than a normal distribution or a fit is too slow? zfit allows to build multidimensional, composed models of arbitrary shaped PDFs. The backend uses speedup-techniques from TensorFlow to speedup and run on GPUs Used in High Energy Physics with large data & complicated PDFs General likelihood fitting ● Wraps minimizer libraries ● Minuit, Scipy, Ipyopt, NLOpt ●Convenient BaseClass available ●Common convergence criterion ●Automatic gradient available ● Access results ●Calculate errors ●Store results res_dilled = zfit.dill.dumps(result) res_loaded = zfit.dill.loads(res_dilled) Jonas Eschle (jonas.eschle@cern.ch) for the zfit team Compositions Mixture (plot), Convolutions, Products Parameter Data Build arbitrary compositions ● Multiple formats supported ● Full capability of Pandas DataFrames Model building Composition Custom model Product 2-D (dims defined by observables) Variety of losses Binned,unbinned, chi2, extended Fast likelihood model fitting in pure Python for complicated distributions. It allows to connect with many other libraries for a seamless workflow. Conclusion hepstats library Confidence Interval, limits, sWeights,... Inference


Study of multiplicity-dependent charmonia production in p+p collisions at PHENIX Jongho Oh and Sanghoon Lim for the PHENIX collaboration Motivation PHENIX muon spectroscopy Charmonia measurement Results Multiplicity-dependent 𝐽/𝜓production Comparison with other results ‣ Forward Silicon Vertex Tracker - 4 stations of silicon strip detector - precise measurement of the radial direction of track trajectory at forward rapidity - charged particle multiplicity ‣ Muon Tracker - 3 stations of cathode strip chamber - momentum measurements of charged tracks ‣ Muon Identifier - 5 layers of 2 planes of Iraocci tube chambers and steel absorber - hadron/muon separation PHENIX muon arms are composed of Forward Silicon Vertex Tracker, Muon Tracker, and Muon Identifiers to measure hadron/muon tracks at forward rapidity region • At least one MuTr-FVTX matching is required to separate 𝐽/𝜓and 𝜓(2𝑆) • Signal shape: Crystal ball function and 2nd Gaussian function • Combinatorial background: Mixed events normalized with like-sign • Correlated background: Modified Hagedorn function based on the measurements of correlated dimuons Phys. Rev. D 99, 072003 (2019) • 𝐽/𝜓and multiplicity at mid-rapidity èA similar multiplicity dependence is observed in 200 GeV and 13 TeV Tracks from 𝐽/𝜓are included in both results, but more significant impact in 200 GeV due to smaller multiplicity (𝑑𝑁!"/𝑑𝜂in 13 TeV is about x3 larger than 200 GeV) • PHENIX results without subtraction of muons from 𝐽/𝜓 èA similar multiplicity dependence with the LHC results • After the subtraction of muons from 𝐽/𝜓 èSignificantly lower multiplicity dependence than STAR results (same collision energy without subtraction) ALICE results (higher collision energy without subtraction) • At 200 GeV where 𝑑𝑁!"/𝑑𝜂is comparable with 2 (tracks from 𝐽/𝜓), considering the muon contribution is very important to interpret the multiplicity dependence • Multiparton interaction is important for 𝐽/𝜓production for both energies collective behavior arXiv:1906.09928 South arm −2.2 < 𝜂< −1.2 North arm 1.2 < 𝜂< 2.4 Phys. Rev. C 105, 065912 (2022) Phys. Lett. B 810 (2020) 135758 Phys. Lett. B 786 (2018) 87 • 𝐽/𝜓at forward rapidity and multiplicity at mid-rapidity èIncreasing yield as charged particle multiplicity becomes larger • 𝐽/𝜓at forward rapidity and multiplicity at backward rapidity èA similar trend in the results with the multiplicity at mid-rapidity • 𝐽/𝜓and multiplicity at the same rapidity (forward rapidity) Multiplicity without subtraction of muons from 𝐽/𝜓 èMore steeply increasing than other results Multiplicity with subtraction of muons from 𝐽/𝜓 èWeaker multiplicity-dependence and similar trend with other results • Comparison with PYTHIA8 A better agreement with the Detroit tune for RHIC energies than the Monash tune Monash Tune Detroit Tune Phys. Rev. D 105, 016011 (2022) Outlook • Multiplicity-dependent 𝐽/𝜓and 𝜓(2𝑆) ratio is ongoing to study final-state effects in p+p collisions • Two PYTHIA tunes show different multiplicity dependence in the 𝐽/𝜓and 𝜓(2𝑆) ratio èAnother check of the underlying event description • Inclusive 𝐽/𝜓yield increases with particle multiplicity in p+p collisions at 13 TeV and 200 GeV èSimilar multiplicity dependence at two energies èMultiparton interaction is important for 𝐽/𝜓production in both energies 𝐽/𝜓and charged particle multiplicity at mid-rapidity èCharged tracks of the decay product are included in the charged particle multiplicity èMultiplicity dependence is possibly affected depending on 𝑑𝑁!"/𝑑𝜂values • In PHENIX, multiplicity can be measured in various regions èDetailed correlation between 𝐽/𝜓production and underlying events can be investigated Phys. Rev. C 95, 034904 (2017) • Relative suppression of 𝜓(2𝑆) than 𝐽/𝜓 becomes stronger as the multiplicity density increases in p/3He+A collisions èFinal-state effects • The study can be extended even in p+p collisions èThe system size is small but almost independent of the multiplicity


Use of L1 phonotactics in initial foreign-language speech segmentation Katie Von Holzen, Sophia Wulfert & Holger Hopp Technische Universität Braunschweig, Germany | English and American Studies k.vonholzen@tu-braunschweig.de Speech Segmentation ■Identification of words in incoming speech stream ■Segmentation strategies are learned and language specific1 References 1. Cutler A. Listening to a second language through the ears of a first. Int J Res Pract Interpret. 2001;5(1):1-23. doi:10.1075/intp.5.1.02cut 2. Hu, C. F. (2014). Extracting phonological patterns for L2 word learning: The effect of poor phonological awareness. Journal of Psycholinguistic Research, 43(5), 569–585. doi: 10.1007/s10936-013-9269-z 3. Earle, F. S., & Arthur, D. T. (2017). Native phonological processing abilities predict post-consolidation nonnative contrast learning in adults. The Journal of the Acoustical Society of America, 142(6), EL525–EL531. doi: 10.1121/1.5013141 4. Finn AS, Hudson Kam CL. The curse of knowledge: First language knowledge impairs adult learners’ use of novel statistics for word segmentation. Cognition. 2008;108(2):477-499. doi:10.1016/j.cognition.2008.04.002 5. Weber A, Cutler A. First-language phonotactics in second-language listening. J Acoust Soc Am. 2006;119(1):597-607. doi:10.1121/1.2141003 6. Graf Estes, K., Gluck, S. C.-W., & Grimm, K. J. (2016). Finding patterns and learning words: Infant phonotactic knowledge is associated with vocabulary size. Journal of Experimental Child Psychology, 146, 34–49. doi: 10.1016/j.jecp.2016.01.012 7. Haman, E., Miller, A., Wodniecka, Z., Koegler, H., & Łuniewska, M. (2017). Crosslinguistic Lexical Tasks: American English version (CLT-AM-EN). A part of LITMUS COST IS0804 Battery. Unpublished material. 8. Weber, J., Marx, P., & Schneider, W. (2007). Die Prävention von Lese-Rechtschreibschwierigkeiten bei Kindern …. Zeitschrift für Pädagogische Psychologie, 21(1), 65–75 9. Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis-Kaplan Executive Function System (D-KEFS). doi: 10.1037/t15082-000 Phonotactic Cues ■Probability that certain sequences of phones align with word boundaries ■Advanced adult L2 learners continue to apply L1 phonotactic cues when segmenting speech in their L24,5 Participants ■n = 114; 1st and 2nd graders in Germany Age M = 7;6; SD = 0;9; range = 6-10 years ■Language Background: 83 L1 German 31 German + Lx (Arabic, Bulgarian, Chinese, French, Italian, Catalan, Polish, Portuguese, Russian, Serbian, Spanish, Turkish, Urdu) ■English experience: < 10% passive exposure and unable to complete Production CLT in English7 L1 Skills ■Young children‘s L1 skills influence their processing of novel phonotactic forms6 Paradigm We searched for the merse nart profoundly. nart nuttiff Sentence: Word: % word acceptance The lies about my doon roshaf persist (Target) (Lure) Stimuli Speech Segmentation L1 skills Clear Boundary: doon_roshaf Clear L1 phonotactic cue to word boundary Length: Short: roshaf Long: nroshaf Ambiguous Boundary: dook_roshaf Ambiguous L1 phonotactic cue to word boundary Length: Short: roshaf Long: kroshaf Phonological Awareness RQ2: Do pre-EFL students use phonotactic cues from their L1 German to segment words from English? RQ3: Is pre-EFL students’ ability to segment words from English speech influenced by their phonological awareness skills? Phonological Awareness ■Ability to reflect on and manipulate phonemic segments ■Support learning of L2 phonological contrasts and words2,3 RQ4: Is pre-EFL students’ use of phonotactic cues from their L1 German to segment words from English influenced by their L1 skills?  Word Status Effect: Word acceptance greater for short Target compared with short Lure words RQ1: Pre-EFL students can segment words from English, before receiving instruction in English  Interaction between Word Status and Phoneme Manipulation Score8: Word Status Effect increases with higher phoneme manipulation scores Phonotactic Cues  Length Effect: Word accepta


L Carr1,2, C Palego2, D Arnaud-Cormos1, P Leveque1 1) Univ. Limoges, CNRS, XLIM, UMR 7252, F-87000 Limoges, France 2) School of Electronic Engineering, Bangor University, UK Influence of pulse duration on intracellular calcium concentration for sub-10 ns pulses Introduction This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 737164 SUMCASTEC. Calcium ions (Ca2+) play a key role in a wide range of cellular processes. Intracellular calcium concentrations [Ca2+]i are known to increase following nanosecond pulsed electric field (nsPEF) exposure [1]. This increase is caused by Ca2+ entering the cell from the extracellular media and/or being released from intracellular calcium stores, such as the E.R. [2]. In both cases membrane poration is believed to be critical for the movement of Ca2+. In this study we characterise changes in [Ca2+]i following the application of single sub-10 ns pulses. We also attempt to identify the source of calcium involved in the post-pulse increase. 1. Batista Napotnik 2016, Bioelectrochemistry 110: 1– 12; 2. Semenov I 2013 Biochim Biophys Acta 1828:981–9; 3. Charuk 1990, Analytical Biochemistry, 188(1), 123–131. Results Amplitude of [Ca2+]i increase is dependent on pulse duration Figure 3. A: Change in fluorescence over time plot, from live cell imaging, for U87 cells loaded with 0.5 µM FLUO-4 exposed to a single 250 kV/cm pulse of durations varying between 2-10 ns. Each line shows average fluorescence change from at least 20 cells from a minimum of 5 separate experiments. Error bars show SE. B: Representative live cell images of U87 cells loaded with 0.5 µM FLUO-4 before and after exposure to a single 2 or 10 ns, 250 kV/cm pulse. Cells have been pseudo coloured for clarity and scale shows fluorescence in arbitrary units. -5000 0 5000 10000 15000 20000 25000 0 20 40 60 80 100 120 140 Fluorescence change (arbitrary units) Time (seconds) Pulse 10 ns 4 ns 6 ns 8 ns 2 ns 0 ns A. Time post pulse Pre pulse 3 s 32 s 100 s 10 ns 2 ns B. • Immediate increase in [Ca2+]i following pulse • The amplitude of this increase is dependent on pulse length • Return towards baseline within 60 seconds of pulse Both extracellular and intracellular calcium sources contribute to [Ca2+]i increase -500 0 500 1000 1500 2000 2500 0 20 40 60 80 100 120 140 Fluorescence change (arbitrary units) Time (seconds) Pulse 10 ns 4 ns 6 ns 8 ns 2 ns 0 ns -5000 0 5000 10000 15000 20000 25000 0 20 40 60 80 100 120 140 Fluorescence change (arbitrary units) Time (seconds) Buffer with Ca2+ Buffer without Ca2+ 10 ns pulse Figure 4. Change in fluorescence over time plot for U87 cells loaded with 0.5 µM FLUO-4 and pulsed in a Ca2+ free buffer. Cells were exposed to a single 250 kV/cm pulse of durations varying between 2- 10 ns. Each line shows average fluorescence change from at least 20 cells from a minimum of 5 separate experiments. Error bars show SE. • Pulses of 4 ns and longer result in a release of intracellular calcium stores • Similar maximum fluorescence for 4, 6 and 8 ns pulses, but different kinetics • Extracellular calcium is the dominant source of the [Ca2+]i increase To see if intracellular calcium stores contribute to the [Ca2+]i increase, cells were pulsed in a calcium free extracellular buffer. Figure 5. Comparison of the FLUO-4 response for cells exposed to a single 10 ns, 250 kV/cm pulse in the presence or absence of extracellular calcium. Each line shows average fluorescence change from at least 20 cells from a minimum of 5 separate experiments. Error bars show SE. Nanopores may not be the only way Ca2+ passes through the plasma membrane -500 0 500 1000 1500 2000 2500 3000 3500 4000 0 20 40 60 80 100 120 140 160 180 Fluorescence change (arbitrary units) Time (seconds) 10 ns 4 ns 6 ns 8 ns 2 ns 0 ns Pulse 2 ns + 50 µM RR 2 ns Pulse -5000 0 5000 10000 15000 20000 25000 0 20 40 60 80 100 120 140 Fluorescence change (arbitrary units) Time (seconds) 10 ns 10


Setting the scene for co-creating Citizen Science Hubs V.G. Psomiadis, A. Bakousi, I. Tavantzis, K. Karatzas, A. Vakali, A. Mazaris, E. Stylianidis Aristotle University of Thessaloniki, Thessaloniki, Greece This work has received funding from the European Union’s Horizon 2020 research and innovation programme under Grand Agreement no. 101005330. The content of this poster reflects only the authors' view and the Commission is not responsible for any use that may be made of the information it contains. Visit the INCENTIVE project website for more information Browse the INCENTIVE Citizen Science Digital Toolkit web app Virtual & Physical Presence Costly Wasted resources Gender and social inequalities Large carbon footprint Risk of disease transmission Lower costs No commuting Environmental friendly Social and gender equity Access across time zones Opportunities and networking Face-to-face interactions Social connections & companionship Disconnection Inefficiencies Potentially lack of trust Impersonal Faceless Prone to technical glitches PROS CONS Engagement Activities Considerations • Citizens groups • Level of stakeholders' influence on the activities • Openness to the changeability of collaboration arrangements by the involved stakeholders • Informal communication paths • Types of engagement of the various stakeholders’ determination • Available tools • Awareness of local community • Community’s needs and expectations • Data policy Targets • Stakeholder & new researchers' engagement • Partnerships • Scientists’ capacity-building • Literacy enhancing • Knowledge exchange • Networking • Mobilizing the CSH community Citizen Science Hubs CITIZEN SCIENCE HUBS Methodological Guide Create a checklist of essential CSH components Step 1 Case study catalogue: good practices and activities proven to be successful Step 2 Pilot phase for running the CSH Step 3 Evaluation of steps 1-3 Step 4 Improve, enrich, alter steps 1-3 Step 5 Technical Implementation • Establishment procedures • Ethics & diversity aspects • Funding aspects • Administration support • Main objectives • Physical & virtual presence Activities • Research • Awareness-raising & engagement • Mutual learning and networking • Capacity-building • Monitoring and evaluation A step-by-step checklist to facilitate in the set- up and implementation phase of CSHs A case study catalogue to draw inspiration from for the set-up and running of future CSHs A virtual asynchronous discussion space for serving the needs of CSHs and empowering CS stakeholders A crowdsourced online observatory for raising awareness and inspiring grass-rooted invention and creativity An open directory for easy access to publicly available CS resources Achievements & Expectations RESEARCH • Good practices for CSH • Integration of RRI keys to the processes of the CSH • Scientific outcomes CITIZENS • Number of activities that have affected the scientific skills and knowledge of the citizens • Increasing number of actively involved citizens • Researcher-Citizen cooperation assessment • More citizen involvement per research stage HUBS • Efficient support for the establishment and further growth of a CSH • Attract, engage and sustain stakeholders around the Hubs ecosystems Open Challenges Engagement “Speaking the same language” as the citizens involved Active involvement and commitment of the policymakers Maintain quality and impact Improve openness and transparency Strengthen learning and creativity Optimize organization, communication, and sustainability Establish suitable credits and rewards Develop ethical and legal procedures Balance between society and researchers Respond to needs of citizen scientists Operation Secure funding for CS projects Choose the right technical infrastructure and tools Activities Citizen Science Hubs discussion forum An open environment for exchanging good practices, mutual learning and nurturing novel ideas and solutions Digital library of Citizen Science resources A repository of pu