This work is licensed under a Creative Commons Attribution 4.0 International License. © 2019 Department for International Development Institutions Institutions A comparative assessment of Ethiopia, Ghana, Kenya, Nigeria, Rwanda, Tanzania and Uganda Research environment The number of universities is booming to satisfy demand for higher education but the eﬀects on research are limited. No country meets the African Union goal of 1% GDP invested in research and development.¹ Governments see research as part of the broader science, technology and innovation agenda: only two countries have a research policy, but six have an STI policy. In many countries there is an opportunity to create stronger national research institutions: four countries have neither a research ministry nor a national research funder. Foreign R&D contributions play a large role in many African countries, but evidence on their economic impact is limited.¹ Most African countries have relatively few researchers: there is a need to make research a more attractive career option.¹ This data comes from a needs assessment study of the research systems in seven African countries, produced for the UK Department for International Development. The full set of infographics and the underlying analysis is available at http://bit.ly/SRIA2020 National research policy National STI policy 2/7countries 6/7 countries National research/STI funder Ministry/dep’t for research 3/7countries 3/7countries 0.0% 1.0% Ethiopia Ghana Kenya Nigeria Rwanda Tanzania Uganda 0% 70% Ethiopia Ghana Kenya Nigeria Rwanda Tanzania Uganda R&D Funding 0 S. Afr. 2.5 Ethiopia Ghana Kenya Nigeria Rwanda Tanzania Uganda No. Universities R&D Int’l Funding 0 600 Ethiopia Ghana Kenya Nigeria Rwanda Tanzania Uganda S. Afr. No. Researchers 1 UNESCO, “UIS Statistics,” 2019: http://data.uis.unesco.org Researchers/million inhabitants Universities/million inhabitants % of total R&D funding % of GDP


Wohin mit… Sprachdaten? Bayerisches Archiv für Sprachsignale Repository Start Daten- management- plan? Dokumentieren Analysieren Sammeln Analysieren Sammeln ja nein §§§ Webdienst COALA • generiert CMDI Metadaten aus Tabellen • Ingest der Audio- und Annotationsdaten


Discussion: Examples of the time series are shown in Figure 2. Images of Active Galactic Nuclei (AGN) sources generally become more compact with increasing frequency, as shown in Figure 3. It has often been assumed that VLBI source positions, as determined by measuring the source’s VLBI phase center, should be more stable at higher frequencies. This is the assumption we are testing with these comparisons. But we find that these comparisons are difficult to make and interpret due to the different nature of the X/S and K sessions and the different networks used. The X/S and K VLBA astrometry sessions mostly look at different sources. The IVS X/S R1, R4 and RDV/RV sessions have larger networks than the VLBA, particularly with better North-South extent and with baselines crossing the equator, leading to smaller declination uncertainties and less asymmetry. However, the East- West coverage of the IVS networks vs the VLBA are not so different, and the data gives a slight edge to K band in right ascension in terms of WRMS scatter. There is no reason to expect that the true average source position variability would be systematically greater in declination than right ascension and there is also no reason to expect that the true average source position variability would increase from the northern to the southern part of the sky. Therefore we attribute the larger WRMS scatter for K band in declination to be a network effect and we believe the indication is that the true position variability is less at K band than at X/S band. Figure 3: Near-simultaneous images of NRAO140/J0336+3218 at S (2.3 GHz), X (8.6 GHz), K (24 GHz) and Q (43 GHz) bands from a study of VLBA observations of 453 ICRF sources from April - June 2021 (Hunt et al, 2022, de Witt et al, 2022), which shows that VLBI images of ICRF sources become more compact with increasing frequency. Note how the jet in this example fades with increasing frequency. The VLBA synthesized beam is shown as the grey ellipse in each sub-figure. Conclusion: Sources do appear to be more stable at K than X/S band, on average. However our ability to measure and quantify this is limited by network differences and the limited amount of overlapping source data at the two bands. Acknowledgements: The authors acknowledge use of the Very Long Baseline Array under the US Naval Observatory's time allocation. This work supports USNO's ongoing research into the celestial reference frame and geodesy. The VLBA is operated by the National Radio Astronomy Observatory, which is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. K vs X/S comparisons: Both the X/S and K band data required some additional editing to remove positions that were very noisy or where there were too few observations in the session. For a source to be used we required that it be in at least 10 sessions with at least 10 observations in each session and have uncertainties of no more than 1.0 milli-arc-second (mas) in each session. Then, two methods were used to estimate the scatter for each source in each band. In the first method, weighted root mean squares (WRMS’s) about the mean of each source’s position were computed in RA and declination using the RA and declination formal errors for weighting. The WRMS’s of 417 common sources were then compared. Itn this method, ~56% of the sources exhibit less scatter in RA, but only ~36% exhibit less scatter in declination at K band. In the second method, a more complicated procedure was used to compute WRMS’s about the means by using the full covariance matrix for each session, but the results are similar. In this method, ~60% of the sources show less scatter in RA but only ~34% show less scatter in declination at K band. We show this graphically in Figure 1 for the second method where the logarithm of the ratio of the WRMS’s at K vs X/S is plotted vs declination for each matched source. Values greater than zero indicate less scatter in


Jensen CL, Bibbo J, Rodriguez KE, O’Haire ME. The eﬀects of facility dogs on burnout, job-relatedwell-being, and mental health in paediatrichospitalprofessionals. Journal of Clinical Nursing. 2021 Maurice C, Engels C, Canouï-Poitrine F, Lemogne C, FromanKn I, Poitrine E. Dog ownership and mental health among community-dwelling older adults: A systemaKc review. Int J GeriatrPsychiatry. 2022 Ginex P, Montefusco M, Zecco G, Trocchia MaTessich N, Burns J, Hedal-Siegel J, Kopelman J, See Tan K. Animal-Facilitated Therapy Program: Outcomes from caring canines, a program for paKents and staﬀ on an in paKent Surgical oncology unit Clinical Journal of Oncology Nursing. 2018 Mueller MK, Gee N, Bures RM. Human-animal interacKon as a social determinant of health: descripKve ﬁndings from the health and reKrement study. BMC Public Health. 2018 SNOOPY the media)on dog at Ins)tut Curie: a team eﬀort Marguerite Nicodeme1, Maxime Cheron1, Elodie Labedade1, Hedi Chabanol1, Adeline Gigan;1, Philippe Mont1, Hind Baba Aïssa1, Caroline Gilbert2, Dörthe Nickel3, Isabelle Froman;n1, Virginie Bel3 1. Unité Recherche Plaies et Cicatrisa;on, Ensemble Hospitalier, Ins;tut Curie; 2. ENVA, UMR 7179 CNRS/MNHN; 3. Direc;on du Centre de Recherche, Ins;tut Curie To oﬀer to the project team and all Ins3tut Curie staﬀ a happy and friendly presence, in order to lighten the burden of busy days in terms of both work density and emo3onal load. REFERENCES EULIFE -Mee*ng June 6th, 2023 it’s &me for SNOOPYTHERAPY 2 MAIN OBJECTIVES Background situa.on High stress levels for medical professionals Suﬀering and lack of communica3on by pa3ents Post-Covid crisis – loss of social coherence METHODS hospital wai*ng room consulta)on room Interac3ons with pa3ents FIRST RESULTS a two-year-old English seFer who was adopted from the SPA animal rescue center in 2022 Experts team A vet and animal behaviour expert at Na3onal Veterinary School A occupa3onal therapist and lecturer at Univ. Paris Est Créteil A professional dog trainer A team of 5 specially trained nurses NOOPY ? WHO IS WORKING TOGETHER TO BEAT CANCER A"er Curietherapy and Immunotherapy NOOPY FAMILY Research Care Genera3on & Preserva3on of knowledge Ins3tut created by Marie Curie in 1909 CONTEXT Envisioning the research centres of the future Choice of the dog Not too big Floppy ears to avoid appearing aggressive Robust and healthy With a calm temperament and familiar with humans Balance of spirit Training period Posi3ve educa3onal model Hospital wai)ng room Evalua3on: Who ? Impacts ? Internal staﬀ and pa3ents Quality of work life, stress level First month of work with Cancer pa3ents, non communica3ve pa3ents, > 75 years old, adolescent cancer pa3ents Stressed clinicians Consulta3ons and wai3ng room Before stressful examina3ons Health and safety charter validated Many posi3ve surprises Countless smiles A canine project full of humanity More than a colleague on 4 paws Snoopy is a super doctor New links between Hospital and Research Center Animals can provide solu.ons, they Encourage communica3on and interac3on Bring posi3ve distrac3on Reduce anxiety + many Snoopy volunteers 3 employees on 3 sites 3,700 missions Improve project management Mi3gate limi3ng factors Reﬂexion about a second dog? Possibility of replica3ng the project: other Curie sites, the Research Center 🐶, other establishments in France and beyond. PERSPECTIVES FOR THE FUTURE CONCLUSION To provide Snoopy 3me on request to pa3ents for whom the presence of a dog could be beneﬁcial: non-communica3ve or very anxious pa3ents, in oncogeriatrics, adolescent consulta3ons. virginie.bel@curie.fr - maxime.cheron@curie.fr


A flare is visible in Transit 1 and may contaminate any planetary signal that would otherwise have been observable. Integrated AU Mic b, or not AU Mic b: the question of the young exoplanet's escaping atmosphere Do young Hot Neptunes exhibit atmospheric escape in Lyman-alpha spectra? There are a handful of detections of Hot Neptune transits with Lyman-alpha, as well as non-detections. Detections indicate the presence of escaping neutral hydrogen. We expect low density, close-in planets to be losing some or all of their atmospheres due to their irradiation. K2-25b is a young, close-in, Neptune-sized planet that did not indicate the presence of escaping neutral hydrogen (Rockcliffe, et al., 2021). Keighley Rockcliffe, Elisabeth Newton, Allison Youngblood, Peter Gao, Peter Plavchan, Eric Lopez HST/STIS Lyman-alpha transits of AU Mic b AU Mic b is another young, close-in planet that can provide more insight into atmospheric escape. Transit 1 of HST shows no significant transit of an escaping neutral hydrogen atmosphere, similar to K2-25b. keigh.rockcliffe@gmail.com kerockcliffe.com Transit 2 of HST complicates the picture, showing a potential planetary or stellar signature. The timescale of this steady increase in Lyman-alpha flux is too long to be attributed to the documented "breathing" effect. The increase is also offset in time from where an escaping neutral hydrogen tail is expected (after mid- transit). Scan for more info The timescale for AU Mic to photoionize any neutral hydrogen escaping AU Mic b is about 0.7 hours. K2- 25b has a similarly short timescale of about 2.5 hours. It may be that these planets have ionized hydrogen outflows that would not be observable at Lyman-alpha (Owen, et al., 2021). This work was done at Dartmouth College, which resides on unceded Abenaki land. ISM ISM


ANÁLISE DO ESFORÇO MUSCULAR DURANTE A EXECUÇÃO DOS MOVIMENTOS DE FLEXÃO E EXTENSÃO DE PUNHO EM PACIENTES COM DOENÇA DE PARKINSON - UM ESTUDO PILOTO Samila Costa*, Amanda Rabelo*, Luiza Luiz*, Luciane de Souza**, Nayara Faustino*, Marcus Vieira*** e Adriano Andrade* *UFU, **UFTM, ***UFG 1. INTRODUÇÃO A ergonomia de qualquer solução ortótica é vital para a sua adoção efetiva na fisioterapia relacionada à DP. Nesse sentido, trabalhos realizados anteriormente no Núcleo de Inovação e Avaliação Tecnológica em Saúde (NIATS) destinaram-se ao estudo de variáveis ergonômicas que devem ser levadas em consideração para o uso de uma órtese ativa de punho, na prática clínica, a fim de prover dados necessários ao aprimoramento do dispositivo disponível. Um dos estudos realizados avaliou o esforço muscular dos flexores e extensores de punho, no plano sagital eixo latero lateral, com e sem o uso do dispositivo ortótico. Os resultados mostraram que o esforço muscular exigido do flexor de punho era menor durante o uso do dispositivo ortótico, concluindo que o peso da órtese combinado com a força gravitacional facilita o movimento de flexão. Diante do exposto, este estudo tem como objetivo avaliar a influência da mudança de plano e eixo no esforço muscular durante a execução dos movimentos de flexão e extensão de punho em pacientes com DP. Optou-se pela realização de um piloto para verificar o esforço muscular dos flexores e extensores de punho no plano transversal eixo longitudinal o qual sofre uma menor influência da força gravitacional. 3. RESULTADOS O Gráfico 1. mostra a análise, baseada na média da porcentagem de ativação muscular (% CVM) dos Sujeitos. Os dados utilizados para o cálculo da média foram obtidos durante os movimentos de flexão-extensão do punho, no plano sagital, eixo latero lateral, em seguida o mesmo protocolo foi realizado no plano transversal eixo longitudinal. Gráfico 1. Comparação entre o % MVC para os músculos flexores e extensores nas posições vertical e Horizontal. 2. MATERIAIS E MÉTODOS Participaram deste estudo dois indivíduos diagnosticados com a Doença de Parkinson, um homem e uma mulher, com respectivamente 62 e 56 anos, classificados pela escala Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS), em grau moderado. O protocolo experimental foi explicado detalhadamente para cada voluntário. Para quantificar a atividade muscular máxima dos sujeitos, a Contração Voluntária Máxima (CVM) foi adquirida e analisada. Os dados da CVM foram utilizados como valores de referência para comparação dos dados resultantes da tarefa proposta. A Figura 1. mostra a posição do antebraço e punho durante a realização das tarefas. Os sinais de EMG foram coletados simultaneamente dos músculos flexores e extensores do punho. 4. DISCUSSÃO Este estudo concentrou-se em analisar e comparar esforço muscular durante a realização dos movimentos e flexão e extensão de punho, no plano sagital eixo latero lateral, com o mesmo protocolo realizado no plano transversal eixo longitudinal. No movimento de flexão esse aumento chega a aproximadamente 46,57% e ocorre, pois, quando realizado no plano sagital, o peso do punho e da mão, combinado com a força gravitacional, favorece o movimento exigindo um menor esforço muscular. Desta forma ao se repetir o mesmo movimento no plano transversal, onde a força gravitacional tem menor influência e não favorece o movimento, o %CVM do flexor aumenta. Para o movimento de extensão esse aumento não é tão expressivo, cerca de 11%. Estes resultados preliminares permitem concluir que estudos que avaliam esforço muscular utilizado o músculo flexor de punho, devem ter cuidado ao definir o protocolo, uma vez que o movimento realizado no plano sagital eixo latero-lateral, sofre com influência da força gravitacional, o que interfere de forma significativa no esforço muscular avaliado. O que não acontece de forma tão expressiva com os extensores. Figura 1. A e B, respectivamente, extensão e flexão


Flanders Bio Imaging – towards efficient centralized research data management and analysis of bioimaging data Sebastian Munck1,2,9, Christopher Cawthorne1,3,9, Tatiana Woller1,2,4,9, Benjamin Pavie1,2,9,10, Alexander Botzki4,5,9, Frank Vernaillen6, Raf De Coster7,9, Paul Borgermans8,9, Ingrid Barcena Roig 8,9, , Mariana Montes8,9 To make modern data management and analysis that is committed to FAIR principles and improved reproducibility a reality, Flanders BioImaging in a team effort with the Flemish supercomputing center (Vlaams Supercomputer Centrum, VSC) and KU Leuven’s central IT infrastructure, is exploring new models for data management, metadata handling, and image analysis. Research data management (RDM) Versatile HPC for users with distinct needs Due to the diversity in microscopes, biological images are heterogenous, leading to a plethora of distinct analyses. Hence, image analysts require a flexible and powerful environment to carry out their work. In the OnDemand server at the VSC, users can select virtual desktops with dedicated software (Band, Neurodesk), cluster desktop or web-based interactive environments (Jupyter Lab, R Studio server)… Conclusion and prospects Thanks to this collaboration, we aim at: 1. FAIR RDM and analysis by design 2. Single point of access to enhance reproducible analysis 3. A platform for collaboration on bioimage analysis Affiliations 1.Flanders Bio Imaging 2.Bioimaging core, VIB 3.Molecular Small Animal Imaging Center, KU Leuven 4.Elixir Belgium 5. Technology training core, VIB 6. Spatial Catalyst, VIB 7. Center for Brain and Diseases Research, VIB 8. Flemish supercomputer center (VSC) 9. KU Leuven 10. UGent Globus Data deposition Automatic extraction metadata Automatic transfer from instruments Use of ontologies with schemas Policies, automation, data discovery Bio -Formats REMBI MITI MIAPE ISO Schema manager In general, RDM is often postponed until it becomes crucial. However, there is an increasing number of editors and funding agencies requiring open or findable accessible interoperable reusable (FAIR) data. While going through the data-lifecycle, we attempted to find a golden mean between FAIR data and the time invested by researchers to achieve FAIR data. Hence, we automatized each step, where possible, of the data lifecycle. With ManGO data is stored and annotated, with metadata to contextualize and make it findable. Data workflows are automated helping to reduce manual work and mistakes. All this via different user interfaces making ManGO accessible for everybody and from everywhere. Rstudio server Jupyter Lab Bioimage analysis desktop HPC Institutional repositories Neurodesk


WOMEN INCLUSION IN HUMAN CAPACITY DEVELOPMENT; THE SUB-SAHARAN NUCLEAR INDUSTRY Keziah Garba, Ahmadu Bello University, Nigeria Research Question To what extent can human capacity development improve gender equality in the sub-Saharan nuclear industry? Background • Gender equality is pivotal to creating a thriving work environment. • However, women comprise barely 25% of the global nuclear workforce. • In sub-Saharan Africa, the challenges women face in the nuclear sector has affected their workforce participation and ability to access key decision- making positions. • Without initiatives in place to tackle these issues, they threaten the potential of the nuclear industry growth in sub- Saharan Africa Why Sub-Saharan Africa? • Sub-Saharan women experience the highest levels of inequality globally. The main challenges include: • Socio-cultural barriers • Lack of funding • Restricted educational opportunities • Lack of advocacy Methodology • Case studies based on successful initiatives implemented on similar challenges in STEM fields. • Analysis of the specific challenges. • Particular focus on the impact of capacity development. Conclusion • Given the history of economic and social injustices excluding sub-Saharan women from contributing to the nuclear field, human capacity development is essential to improving their competencies. • Governments and international nuclear organizations can play key roles in capacity development through: • Education • Mentorship • By empowering Sub-Saharan women in the nuclear industry, we can foster a more inclusive and gender-balanced sector, enhancing prowess within the field. Recommendations • International nuclear organizations and governments should implement capacity development initiatives tailored toward improving the gender pipeline in the sub- Saharan nuclear sector. • Scholarships for women studying nuclear and related fields at the university. • Encourage the participation of women in nuclear fields through advocacy and empowerment. • Provide capacity building opportunities such as trainings and workshops. Case studies • Regional Scholarship and Innovation Fund (est. 2015) 103343% of total Female PhD Scholars so far • Sciences et Technologies au féminin (Kenya, 2023) • Africa Centre for Excellence (est. 2014) Scan to Connect


Innovative Research for a Sustainable Future www.epa.gov/research Logan J. Everett l everett.logan@epa.gov l 919-541-2495 Overview Screen Design & Analysis Scalable Quality Control Differential Gene Expression Analysis Summary & References High-Throughput Chemical Safety Screening Using Targeted RNA-seq Logan J. Everett, Joshua A. Harrill, Derik Haggard, Joseph Bundy, Beena Vallanat, Imran Shah, Richard Judson U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology & Exposure Research Triangle Park, North Carolina, U.S.A. • U.S. EPA has proposed a tiered testing strategy using New Approach Methodologies (NAMs) to identify hazards from chemical exposure and characterize their dose-response relationships. The first tier of testing will utilize NAMs that are high-throughput and provide broad biological coverage [1]. • Targeted RNA-seq of cultured human cells provides a platform for high-throughput transcriptomics (HTTr) screening that covers >20,000 genes and a wide array of biological responses and pathways [2]. • We successfully piloted the targeted RNA-seq approach for HTTr to predict biological pathway altering concentrations (BPACs) [3] and have now scaled this approach to screen over 1,200 chemicals in three distinct cell types. • We have developed rigorous quality control procedures to remove aberrant samples that are scalable to tens of thousands of sequencing libraries per study. • Differential expression models [4] reveal dose-responsive accumulation of transcriptional changes across cell types and chemicals tested, and signature-based analysis is used to derive potency and mechanism of action information for each chemical. Figure 1. Design and analysis of large-scale high-throughput transcriptomic screens. Left: Dose plates are prepared with ~40 test chemical samples at 8 concentrations (half log10 spacing, single replicates) and a standard set of reference chemicals for each cell type. Cells are grown on the test plate, then treated with chemical samples from the dose plate. Positions of each chemical treatment are randomized on every plate by an automated liquid handling system. Each test plate is generated in triplicate using the same test chemicals, but with separate cell culture batches. QC reference standards are manually added to each test plate before transcriptomic profiling. Right: Raw data from targeted RNA-seq samples is rapidly aligned to known probe sequences producing counts of uniquely aligned reads for each probe in each sample. Probe counts are used to derive QC metrics and are stored in a database layer. Subsequent analysis is performed independently for each chemical. Count data for all concentrations, replicates, and plate-matched vehicle controls are extracted. DESeq2 [4] is used to compute moderated fold-changes, which are then input to a novel method for modeling concentration-responsive activity for a catalog of known gene signatures. Figure 3. Quality control failure rates by sample and cell type. Individual HTTr profiles were excluded from further analysis due to errors in acoustic dispensing of chemicals (red), >50% cell death indicated by cell viability assay (green), or abnormal parameters from a battery of bioinformatic checks applied to sequencing data results (blue, see Figure 2). Greater than 98% of samples pass all QC filters, demonstrating the ability to reliably scale this workflow to studies encompassing thousands of chemicals and samples. Acoustic dispenser logs identify problems with chemical handling Apoptosis/cell viability assays identify cytotoxic concentrations (>50% cell death) Bioinformatic QC checks remove: • Low read depth samples • High rate of alignment failure • Samples with low gene coverage • Samples with irregular count distributions N = 2,509 41,952 36,208 35,559 The views expressed are those of the presenter and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. 1. Th


NASA’s GMAT: a software tool-kit for general space-mission design and space-craft trajectory analysis Nikolaj F. Eriksen1, Tobias C. Hinse1, Jose L. Alvarellos2 and Mads T. Frandsen1 1University of Southern Denmark, SDU-Galaxy, FKF, Denmark 2Private address, California, USA Annual Danish Astronomy Meeting (ADAM) 2024 – 22 - 23 May 2024 -- Comwell Hotel Roskilde, Denmark Abstract: We introduce and raise awareness of NASA’s GMAT (General Mission-design and Analysis Tool) software system tool for spacecraft trajectory optimization and mission design, navigation and orbit analysis. GMAT is developed by NASA Goddard Space Flight Center (GSFC) in collaboration with private industry, public developers and various national space agencies. The tool has applications in all orbital regimes (mission to libration points, LEOs, landing scenarios, gravity-assist fly-by’s). GMAT is fully tested and certified for operational use and was chosen as the primary operational tool for NASA’s ACE (Advanced Composition Explorer) mission for maneuver planning, orbit determination. Various spacecraft models (various thruster models, impulse burn, etc), numerical propagators (Prince-Dormand, Adams-Bashford) and force models (atmospheric drag, solar pressure, etc.) are implemented. GMAT was selected as the primary mission design tool for NASA’s TESS space telescope mission and was used for mission design for the James Webb Space Telescope. At SDU/SDU-Galaxy we have embarked on weekly workshop-like meetings to gradually gain experience with this tool aiming to apply gained knowledge to the Århus University-led “STEP-A” space telescope mission (2025/2026) and optimal geolocation-planning of ground stations (based on predicted TLE’s) for effective Earth-spacecraft communication and data telemetry. This tool can also be used for science communication, STEM outreach activities raising awareness of space science, spacecraft control and astrodynamics. High-level key architecture components of GMAT and their interaction to solve a satellite / space- craft mission design problem. GMAT is highly complex. Each set of components are grouped into functional packages that interact with each other in the process of message passing, information exchange and data flow. The Program Interface component is the top-level interface between user input and the GMAT engine. The interaction with GMAT can either be via a GUI or at scripting level. At engine level we have the core simulation engine controlling the model of the flight dynamics problem in GMAT. Model elements are used to simulate a particular spacecraft mission. For example a model component could be an atmosphere model for Earth or Mars. We have worked out a number of worked tutorials which will be described below for their functionality and purpose. Hohmann Transfer: Going from one circular orbit to another in the same orbital plane is a common maneuver in space missions. This is used in many situations: raising LEO satellites that has degraded because of atmospheric drag, moving a satellite from LEO to GEO or even going to Mars. The Hohmann transfer is a sequence of maneuvers that can do exactly that. The transfer consists of two maneuvers: going to an elliptic orbit with apoapsis in the altitude of the desired orbit then circularize the orbit at the right altitude. Mission to Mars & Mars B-plane: This tutorial focuses on designing a mission to Mars, demonstrating GMAT functions. It starts with an outgoing hyperbolic trajectory from Earth, then performs a Trajectory Correction Maneuver (TCM) to target Mars' B-Plane. Upon approaching Mars, the tutorial adjusts the maneuver to achieve Mars Orbit Insertion (MOI) and places the spacecraft in an elliptical orbit with a 90-degree inclination. Two targeting sequences are created: First Target Sequence: This uses maneuvers in Earth-based Velocity (V), Normal (N), and Bi-normal (B) directions, comprising four propagation sequences. The maneuvers target the BdotT and BdotR c


 Baboons can compensate for foraging costs of low rank  BUT only in low competition environments Rank influences foraging performance? vs   Social bonds mediate rank- related foraging aggression? vs low contribution to social bonds = circles and solid lines, high contribution = squares and dotted lines   2 x environments LOW vs HIGH Foraging Competition Social effects on individual foraging behaviour and performance depend on local environmental conditions Harry H. Marshall1,2,5, Alecia J. Carter1,3,4, Alexandra Ashford1,2, J. Marcus Rowcliffe1 & Guy Cowlishaw1 1Institute of Zoology, Zoological Society of London, U.K. 2 Division of Ecology and Evolution, Imperial College London, U.K. 3The Fenner School of Environment and Society, The Australian National University, Australia 4Current address: Department of Zoology, University of Cambridge, U.K. 5Correspondence address: Centre for Ecology and Conservation, University of Exeter, U.K. h.marshall@exeter.ac.uk Funding: Natural Environment Research Council (NERC) CASE Studentship, Fenner School of Environment and Society Studentship, Leakey Foundation, Animal Behavior Society (USA), International Primatological Society, and The Explorers Club


BAR PATTERN SPEEDS IN CALIFA GALAXIES ULTRAFAST BARS OR TOO LONG BARS? ABSTRACT More than 10% of barred galaxies with a direct measurement of the bar pattern speed host an ultrafast bar. These bars challenge our understanding of the orbital structure of barred galaxies. We analyse the ultrafast bars detected in CALIFA and revise previous analysis. We found that nearly all the sample galaxies are spirals with an inner ring or pseudo-ring and/or strong spiral arms, which falsed previous measurements of bar radius: ultrafast bars are no longer observed when the correct measurement of the bar radius is adopted. V. Cuomo1, Y.H. Lee2, C. Buttitta3, J. A. L. Aguerri4,5, E.M. Corsini3,6, L. Morelli1 1Universidad de Atacama (Chile), 2Korea Astronomy and Space Science Institute (Korea), 3Università di Padova (Italy), 4Istituto de Astrofìsica de Canarias (Spain), 5Universidad de La Laguna (Spain), 6INAF-Osservatorio di Padova (Italy) INTRODUCTION During the evolution of barred galaxies, the rotation of the bar rules the redistribution of mass and angular momentum in the disc. The bar is slowed through the exchange of angular momentum: studing the bar pattern speed Ωbar becomes desiderable (Athanassoula 2003, MNRAS, 341, 1179). The bar rotation rate R=Rcr/Rbar= (Vcirc/Ωbar)/Rbar parametrises Ωbar. This is the ratio between the bar corotation Rcr and bar Rbar radii and allows to distinguish fast (1 ≤ R ≤ 1.4) from slow bars (R > 1.4, Athanassoula 1992, MNRAS, 259, 328). If R < 1 the bars are termed ultrafast (Buta & Zhang 2009, ApJS, 182, 559) but they are unstable (Contopoulos, 1981, A&A, 102, 265). The Tremaine-Weinberg method (TW, Tremaine & Weinberg 1984, ApJ, 282, L5) allows to get Ωbar. It consists in directly measuring the mean velocity and position of a tracer satisying the continuity equation, along slits parallel to the disc major axis. More than 100 galaxies have been analysed with the TW method (Cuomo et al. 2020, A&A, 641, A111): 10% of them hosts ultrafast bars. It is unclear ∼ whether they are the consequence of an erroneous measure or a new class of bars. SAMPLE: ANALYSIS AND MORPHOLOGY We considered the 31 barred galaxies from CALIFA studied with the TW method (Aguerri et al. 2015, A&A, 576, A102; Cuomo et al. 2019A&A, 632, A51): 12 of them host an ultrafast bar. We revised their morphology: most of them hosts an inner ring or pseudo-ring and/or strong spiral arms. These structures make the application of the TW method more difficult. Nevertheless, its applicability to spiral galaxies was demonstrated by both theoretical (Zou et al. 2019, ApJ, 884, 23) and observational studies involving integral-field data (Garma-Oehmichen et al. 2020, MNRAS, 491, 3655). We verified that the TW method was correcty applied to our sample galaxies. Fig. 1 (a): i-band SDSS image of NGC5406. (b): Deprojected image of the galaxy. The red and blue crosses show the peaks from QT(RQb) and QT (Rmean) azimuthal profiles. (c): Ratio map QT(r, φ). The vertical lines indicate the location of RQb (blue) and Rmean (red). (d): Radial profile of <QT>. (e): Azimuthal profile of QT (RQb) and local maxima (asterisks). (f ): Same as (e) but for QT(Rmean). Fig. 2 Comparison between Rmean and RQb. (RE)MEASURING THE BAR RADIUS The values of Rbar used to get R, Rmean, is the mean result of various photometric methods (Guo et al. 2019, MNRAS, 482, 1733). To test the reliability of Rmean, we built the map tracing the transverse-to-radial force ratio QT(r, φ) of the galaxy, following Lee et al. (2020, ApJ, 899, 84). This requires the calculation of the gravitational potential of the galaxy. In turn, it provides an independent estimate of Rbar, RQb, and allows to test whether Rmean matches the bar region. The ratio map QT(r, φ) of a barred galaxy presents four thick slabs and the corresponding peaks mark the four corners of the bar. The location of a peak or a plateau in the radial profile <QT> provides RQb. At this radius, four peaks appear in the azimuthal profile Q


Der Psychologe Abraham Maslow (1908–1970) unterscheidet in seiner Bedürfnis- hierarchie zwischen physiologischen und psychologischen Bedürfnissen. Diese ordnet er in einer hierarchischen Anordnung an. Welches Bedürfnis bedient dein Produkt am ehesten? Die doppelte Entkopplung zeigt, dass wir Effizienz, Konsistenz und Suffizienz zusammen denken sollten. So kann der materiell-ökonomische Wohlstand vom Naturver- brauch gelöst werden und Lebensstile gefunden werden, die uns – unabhängig vom Naturverbrauch – eine wachsende Lebensqualität ermöglichen. Positioniere die Spielfigur wie ein Regler an die Stelle, an der du dein Produkt verorten würdest. Markiere hinterher die gewählte Position mit dem Stift. Gehe die Strategien durch und schreibe zu jeder R-Strategie einen Ansatz, auch wenn es bedeutet, das Produkt von Grund auf neu zu denken. Positioniere die Spielfigur wie einen Regler an die Stelle, an der du dein weiteres Vorgehen verorten würdest. Markiere die gewählte Position mit dem Stift. Beschreibe vier schnelle Ideen, die sich in dem Möglichkeitsraum verorten. Selbstverwirklichung Individualbedürfnisse Soziale Bedürfnisse Sicherheitsbedürfnisse Physiologische Bedürfnisse Welche Umweltwirkungen erzeugt dein Produkt im Laufe seines Lebens- wegs? Mit einer Hot Spot Analyse kann identifiziert werden, wo besonders viel oder besonders wenig Umweltwirkung entsteht. Dann geht es jetzt los mit einer schnellen Reise quer durch die Welt der Kreislaufwirtschaft. Welches Produkt gestaltest du? Dann ist das Spiel hier zu Ende Das Wesen deines Produktes/Vorhabens. Sammlung: Detailarbeit Konzeptionsarbeit angewandt analog angewandt digital spekulativ analog spekulativ digital Aufbereitung: Rohstoff: Produktion: Nutzung: Lebensqualität Naturverbrauch materiell- ökonomischer Wohlstand Reparatur: Beseitigung: Status quo deines Produktes: Grobe Idee schwebt im Raum Mitten im Prozess Redesign Produkt ist schon fertig Produkt soll auf Nachhaltigkeits- potentiale und Kreislauffähigkeit überprüft werden Mit dem Eindruck davon, wie der Lebensweg des Produktes aussieht, können wir mit der MIPS-Bewertung Material und Service in Bezug setzen. Mit Material Input pro Serviceeinheit wird der ökologische Rucksack, also die Menge an Rohmaterialien, die ein Produkt benötigt, berechnet und durch seinen Service geteilt. Keine Zeit für solche Späße Ja! Im Jahr 2015 haben die Vereinten Nationen mit der Agenda 2030 die Sustainable Development Goals (SDGs) für eine globale nachhaltige Ent- wicklung verabschiedet. Ihre Umsetzung soll die Lebensbedingungen von Menschen weltweit und den Zustand des globalen Ökosystems verbessern. Die R-Strategien sind Taktiken mit steigendem Zirkulari- tätslevel, die die Kreislaufführung von Produkten und Materialien unterstützen. Ein und dieselbe Produktart kann in der Umsetzung völlig unterschiedlich auftreten, z.B. indem es eher analog oder digital, spekulativ oder angewandt gedacht wurde. Wie sähe dein Produkt aus, wenn du es in diesem Möglichkeitsraum verortest? Bevor sich der Kreis schließt, nimm dir kurz Zeit für eine Reflexion. Wie geht es jetzt weiter? Gehst du eher in die Detailarbeit und optimierst dein Produkt, oder denkst nochmal über das große Ganze nach und feilst an der Konzeption? An welcher Stelle des Spiels würdest du gerne tiefer eintauchen? Welche Zielkonflikte siehst du? Wo würdest du jetzt anpacken? Recover Lässt sich dein Produkt sortenreiner trennen als Vergleichsprodukte? Wie sieht die Aufbereitung eines exemplarischen Materials deines Produktes aus? Welches Material lässt sich in deinem Produkt nicht stofflich recyceln? Schreibe selbst, wo du stehst. Was ist der wichtigste Rohstoff deines Produktes? Wo wird dein Produkt produziert? Thermische Verwertung – Verbrennung mit Energierückgewinnung. Recycle Repurpose Remanu- facture Refurbish Repair Reuse Reduce Rethink Refuse Recyceln – Materialien verarbeiten, um die gleiche oder eine niedrigere Qualität zu erhalten. Wiederverwendung – Verwendung ausrangierter (Te


OPEN ACCESS UniGe supports green and gold Open Access through the IRIS UniGe institutional archive, the “Policy on open access to the scientific literature”, the activity of Genova University Press and the 7 transformative agreements signed by the University Library System since July 2020. OPEN CONNECTIONS transformative actions forward Open Science at Genoa University Anna Maria Pastorini on behalf of UniGe Open Science Group OPEN DATA OPENSCIENCE.UNIGE.IT GENOA WEEK OPEN SCIENCE GROUP It is the newborn project in UniGe! The Open data repository will be unveiled during next GenOA week 2021. The UniGe Open Science Group is preparing the right environment for the FAIR handling of research data and to support UniGe researchers in the data management plan. The purpose of the openscience.unige.it project is to become a vehicle for collaborative learning and so all academic actors - teachers, researchers, support staff, students and librarians - are involved. It was designed by analyzing the Open Science topics and matching them with the UniGe skills and activities. GenOA week, now in its 3. edition, is an event to support the challenges of Open Science. Organized by the UniGe Open Science Group, it gathers all the Open Science advocacy initiatives of the Ligurian scientific institutions (northwestern Italy). The UniGe Open Science Group represents the synergy between the University Library System and the Research Area staff. Created to promote Open Access, now it deals with the support, and advocacy of all the Open Science topics. CITE AS: AM Pastorini, Open connections: transformative actions forward Open Science at Genoa University, B15 Conference 2021 , doi: 10.5281/zenodo.5497421 REFERENCES - AM Pastorini, GenOA week 2020: i bibliotecari e la sfida dell’ accesso aperto, 2020 [CC-BY] - M Rognoni, AM Pastorini, Islands and bridges: academic librarians towards Open Innovation and the Internet of Things, 2019 [CC-BY]


References: Conclusions: Results: Methods: Introduction: Worrying changes in adolescent e-cigarette use 2014-2019: A secondary analysis of five Irish health datasets J Hanafin, S Sunday, S Keogan, L Clancy TobaccoFree Research Institute Ireland Irish Thoracic Society ASM Virtual 3-4 Dec 2020 • E-cigarette use is increasing worldwide. Concerns about adolescent use include harms (known and unknown), nicotine addiction, and as a “gateway” drug. • Secondary analysis was carried out on five Irish health datasets, with questions on adolescent e-cigarette, all stratified random samples in school-based settings: ECIGS- TFRI 2014 (N=817), ESPAD-TFRI 2015 (N=1508), SILNE-R-TFRI 2016 (N=2051), GUI 2017 (N=6216), ESPAD-TFRI 2019 (N=3556). We report on 16 and 17 year olds. • Descriptive statistical techniques were used to estimate changes in prevalence, reasons for trying e-cigarettes, and relationship with tobacco at first use. Prevalence of ever-use increased from 23% in 2014 to 39% in 2019, representing a rapid increase, particularly since 2016. Curiosity (66%) and friends (29%) are now the two main reasons adolescents use e-cigarettes. Those saying they had never used tobacco when they first tried e- cigarettes increased from 32% in 2015 to 68% in 2019. E-cigarette use has risen rapidly among adolescents in Ireland since 2014. E-cigarettes are not used by adolescents for smoking cessation. Majority of adolescents who use e- cigarettes were not smokers when they started using e-cigarettes, pointing to a worrying new route into nicotine addiction. Current tobacco control regulations for young people should be extended to include e-cigarettes. • Electronic cigarette use among Irish youth: A cross sectional study of prevalence and associated factors. Babineau K, Taylor K, Clancy L (2015). PLoS ONE 10(5): e0126419. doi: 10.1371/journal.pone.0126419 • E-cigarettes: effective cessation tools or public health threat? Clancy L and Babineau K (2016). QJM: An International Journal of Medicine, 109(2): Funding: RCDHT Grant No. 184 Next


The growth-predation risk trade-off in bivalves and fish Daniel van Denderen, Jelle Zandveld, Joost van den Heuvel Introduction Bivalves and teleost fish produce offspring of a constant size. This implies that individuals at early life stages in each group share the same prey and predators, whereas mature individuals may vary in size and ecological niche. Previous work has shown that fish growth is largely invariable of adult size, whereas bivalves show a strong increase in somatic growth with adult size. The reason for this difference between species groups is unclear. In this study, we develop a generic life- history optimization model to examine how growth variation with adult size may originate. THE UNIVERSITY Of RHODE ISLAND GRADUATE SCHOOL OF OCEANOGEAPHY pdvd@aqua.dtu.dk Adapted from Denechere et al. 2022 Hypothesis The size- and feeding-dependent mortality risk of predation varies between teleost fish and bivalves. Large bivalve species will tend to prioritize growth to reach large sizes quickly and outgrow a high predation mortality. Consumption of prey Losses Growth (g) Reproduction (1-g) pEW0.75 – kW1 M = mb + mcWms ∙ p Background mortality Size-based mortality Scalar of energy acquisition Generic life-history optimization model. Using dynamic programming, we determine which allocation pattern and feeding rate maximizes lifetime reproduction. Parameter g and p are optimized. k, mc and ms are varied. E is set to 1. pE is equal to growth coefficient A [g1/4yr-1] Method Mortality Results The exponent that describes size-based predation shifts the relation between the growth coefficient A and adult size. The “red” strategy increases investments in feeding with adult size. The “blue” strategy keeps the investments in feeding more constant with adult size. Juvenile mortality is highest for the “blue” strategy. Conclusion The results confirm the hypothesis that size- and feeding- dependent mortality risk may be the driver of variation of growth coefficient A with adult size between fish and bivalves. Contrary to expectations, large bivalve species have less opportunity to outgrow predation mortality than fish.


Literature Review Laura Mercado Vocational Table 1: Description of the 4 schools selected with SAIs School Name Botijas Laura Mercado ESEVA Berwind Starting Year 2000 2012 2015 2017 Municipality Orocovis San Germán Corozal San Juan Rural/ Urban Rural Rural Rural Urban School type Non-vocational Vocational Vocational Traditional Farm acre(s) 2 32 5 1 Grade level K-8th 6th-12th 9th-12th 6th-8th Expanding Agroecology in Puerto Rico’s K-12 Public Schools: Indicators for Sustainable Continuation Carol E. Ramos-Gerena University at Buffalo, SUNY carolram@buffalo.edu • In 2017, and just a few weeks after Hurricane María hit Puerto Rico (PR), administrators and leaders of the Berwind Middle School faced the risk of being permanently closed. The school was characterized as underachieving and had high violence rates. Leaning on innovation to make a compelling case for their permanence, the school developed a school garden project. • The school garden initiative at Berwind Middle School, “Proyecto Agroecológico Urbano Intermedia Berwind (PAUIB),” provided a model for agroecological integration in other public schools in PR. • Carol Ramos was invited to support a research project involving Berwind Middle School (before Hurricane María) and asked to support parent and community participation in the school. • Through a stakeholder-driven research design process, a study was set out to assess “how do we ensure the long-term continuation of PAUIB?”. The results of this study motivated a broader assessment of the agricultural education offering in PR. • Since 1932, agricultural education (AE) in PR has been included in K-12 schools, but the number of school-based agroecological initiatives (SAIs) are limited. • SAIs exist in the schools that voluntarily integrate agroecology, since there is no legal or regulatory framework, nor institutional support from the Department of Education of PR (DEPR) to promote agroecology. Between 2017-20, a total of 103 schools (of all 812 public schools in PR) were in the AE program of the DEPR. This study found that teachers and school directors voluntarily developed SAIs in both agricultural (vocational and non-vocational) and traditional schools. There is no database available for all the schools with SAIs, therefore these results are limited to the interviewed sample. In the study sample, we observed diverse characteristics for SAIs, as shown below: • SAIs are a relatively inexpensive solution to foster the critical awareness, skills, knowledge and attitudes necessary for future generations to develop the capacity to question and transform the inequities within the colonial and capitalist food system in Puerto Rico 1,2,5,6 and to configure, in the long-term, the agricultural landscape of the country. • A critical component of SAIs program sustainability³ is the commitment, conviction, and leadership of local champions—specifically, teachers and school directors. Their vision and commitment to scale agroecology and overcome the challenges of managing both a school and a farm surpasses the lack of institutional support. Supporting their work through the 10 Factors could help them address their SAIs sustainability challenges. • Schools are highly capable of expanding agroecology horizontally through knowledge exchange⁴, but the organizational sustainability of school gardens3,8 should be addressed for agroecological up-scaling9,10,11 and long-term continuation of SAIs to occur. • SAIs comprise the management and planning of all components in the food system⁷ at the school scale. From food production, cultivation, packaging, distribution (to their home and/or school kitchen), acquisition (selling their production in school agriculture fairs or neighborhood businesses), consumption and waste management (composting organic waste). • Agroecological school planning requires a fundamentally different vision of food systems: through multi-actor cooperation, collective resource management, equitable gender roles and bot


Geobites: Down-to-Earth summaries of new geoscience research for a broad audience Charles M. Shobe (cshobe@gfz-potsdam.de)1, Kristina T. Vrouwenvelder2, Margaret Moerchen3, and Matthew Giampoala3 1. GFZ German Research Centre for Geosciences, 2. University of Colorado Boulder, 3. American Geophysical Union Site visit statistics: the first month Geobites is supported by AGU. most-viewed post published Twitter promotion by AGU new post published •Visitors are primarily from the U.S. and Europe. •Views are driven almost exclusively by social media promotion. •One problem we face is that only 20% of page views are of science posts; we have a high "bounce rate" from the homepage. Geobites is seeking volunteer writers. Please visit www.geobites.org to get in touch. We currently write in English, but are looking to add Spanish as well. Write for Geobites! Follow us on Twitter @_geobites: Geobites is a new grassroots #scicomm blog where geoscientists write about new research for a broad audience. Geobites is one of a family of "bites" sites, where scientists write about new developments in their field for a non-specialist audience. Geobites has three primary purposes: 1.To keep the interested public–especially undergraduates who might be interested in science careers–up to date with new research, 2.To generate attention for new work that traditional science media outlets might miss, and 3.To allow geoscientists to improve their science writing skills, which will improve communication and trust between scientists and the general public. M A R C H 2 6 , 2 0 2 0 B Y C H A R L I E S H O B E What Caused the Flood that (Possibly)Gave Rise to an Empire? Featured image:The YellowRiver Breaches its Course by Ma Yuan,Public Domain Paper: Uraniumisotopic constraints on the nature of the prehistoricflood at the Lajia site, China Authors: Le Li, Jun Chen,David William Hedding,Yuanhe Fu,Maolin Ye,Gaojun Li A smallsand deposit might holdthe key to dating the rise of Chinaʼsfirst dynasty. Chinese legend holdsthat the leaders who worked to control a giant flood on the Yellow River (knowninChinaas the Great Flood)also foundedthe Xia Dynasty–the first centralizedstate inChinese history– about 4,000 years ago.Proving that the Great Flood actually happened would lend weight to ancient historicalaccounts of the foundingof the dynasty,but the evidence is stillup for debate. Some geologists argue that an earthquake caused the Great Flood.The story goes that the earthquake triggered landslidesthat dammed the Yellow River untilthe dam finally broke,releasing about 16cubic kilometers (four millionOlympic-sizedswimming pools) of water virtuallyallat once. Sediments thought to have been carried downriver by the outburst flood have been found infissures—cracks inthe groundcaused by the earthquake—atan ancient human settlement that the earthquake destroyed.Humanremainsfrom the site have been dated to about 3,900 years old.Proponents of the earthquake-causedGreat Flood theory say that the sediment-filledfissures linkthe earthquake and the flood,thereby givingus the birthdayof the centralizedChinese state. But some of the evidence for the theory that the earthquakeand floodare related is controversial.Opponents argue that the timingof the earthquake (andtherefore the dates on the humanremains)canʼt be directly linkedto the flood because the sands in the earthquake fissures might not be sediments from a giant flood.Instead, they say, the sand might have just washed down from nearby gullies. A new paper now argues that the sand inthe earthquake fissures can be chemically linkedto sources up the Yellow River,providinga strong linkbetween the earthquake and the Great Flood. Le Li and coauthors used a new geochemical techniqueto test whether the sand came from nearby gullies,or from upstream inthe Yellow River.They measured the ratio of two different isotopes of uranium(uranium-234to uranium-238)in the sand;this ratio decreases with the time since the sediments were broke


Figure 2. Procedure for generating synthetic EGG time series. Image is adopted from the preprint (Miljković et al., 2023) and shared under the CC BY 4.0 DEED. iFFT stands for inverse Fast Fourier Transform. Research Activities in the Biosignal Measurement & Analysis Research Group Ilija Tanasković1,2, Nenad B. Popović1, Đorđe D. Nešković1,3, Smilja Stokanović1, Mijat Paunović1, Nadica Miljković1,4 1University of Belgrade – School of Electrical Engineering, Belgrade, Serbia 2Institute for Artificial Intelligence R&D, Serbia 3Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade 4Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia About BMA Research Group The Biosignal Measurement & Analysis (BMA) group is an informal research group at the University of Belgrade – School of Electrical Engineering (ETF). The group consists of four PhD students and one alumnus led by Associate Professor Nadica Miljković. Main research focus of the BMA group from ETF is in biomedical and clinical engineering, signal and image processing, as well as in application of Machine Learning (ML). Specifically, the BMA research is related to the measurement and analysis of electromyograms (EMG), electrogastrograms (EGG), electrocardiograms (ECG), impedance cardiograms (ICG), electrodermal activity (EDA), eye tracker data, and other signals in healthy subjects and in patients. This poster highlights selected research topics from the BMA group performed in cooperation with other institutions. Peak Detection and Biometric Identification Novel peak detection algorithm tailored for enhancing the extraction of information of interest in noisy biomedical signals has been developed. The algorithm can be applied on abdominal electrocardiogram (ECG) and eye tracker data (Tanasković & Miljković, 2023; Tanasković et al., 2023a). In the case of abdominal ECG, proposed approach allows fetal heart rate monitoring during the pregnancy, which is the key indicator of prenatal well-being. Furthermore, we combined our knowledge in signal processing and ML to create a biometric identification system using ECG and impedance cardiogram (ICG) data. Our research also digs into the influence of varying emotional states during the interaction with the system, paving the way for further research into human-computer interaction. Nonlinear Dynamics in Heart Rhythm Аnalysis Tools used in the analysis of nonlinear dynamic systems (such as Poincaré plots) are developed and adapted with the aim to uncover the complex mechanisms that govern heart rate variability. Integrating these techniques into routine clinical practice and wearable technology may lead to improvement of patients' monitoring and health outcomes. (Paunović et al., 2024) Figure 1. The comparative analysis of four ML models performance when emotional state of individual differs during the enrolment and evaluation phase. Random Forest (RF), Support Vector Machine (SVM), Linear Discriminant Analysis (LDA), Gaussian Naïve Bayes (GNB). The image is modification of image taken from (Tanasković et al., 2023b) and the image is distributed under Creative Commons Attribution License CC-BY. Feature Extraction and ML for Topographic Maps Currently, we are focusing on the analysis of topographic pressure maps obtained from the matrix-arranged pressure sensors to classify lying postures. The study is oriented towards a thorough examination of the most relevant features and on the most appropriate hyperparameters of machine learning algorithms for successful recognition of lying postures (supine, left lateral, and right lateral subjects' positions). (Nešković & Miljković, 2023) Figure 5. Image shows a Poincaré plot that represents the heart rate dynamics of a sample subject with normal sinus rhythm, sourced from the PhysioNet Normal Sinus Rhythm RR Interval Database. ML for Missing Data Imputation The BMA group research delves into the impact of missing data o


gvv Projet pilote dans les centres de santé urbains Les changements physiques et émotionnels pendant la grossesse  L’importance des consultations prénatales  L’alimentation  Le mode de vie sain  Les signes de danger pendant la grossesse Le baby blues  L’importance de se protéger du VIH Déroulement de l’accouchement L’allaitement au sein  La planification familiale après l’accouchement Prendre soin des nouveau-nés et des femmes après l’accouchement Après une session de respiration et gymnastique du périnée, les sages-femmes échangent avec les futures mamans sur les pratiques qui favorisent la santé et sur le recours aux soins de routine et d’urgence. L’échange se fait sur la base d’un guide d’animation qui présente le déroulement des sessions PAN de façon simple et participative. Fianakaviana Sambatrafisa (FISA) https://fisamada.org  District sanitaire et CSBU* d’Ambanja (Région de Diana)  District sanitaire de Antananarivo Nord et CSBU (Région de Analamanga) *CSBU: Centre de santé à base urbain Terre Innovative Healthcare  https://www.terreinnovative.com/ ©Enfants du Monde e MADAGASCAR PARTENAIRES Les femmes enceintes, les femmes en post-partum et les nouveau-nés sont plus vulnérables face au dérèglement climatique : Des facteurs physiologiques/cliniques font que les femmes enceintes sont plus exposées aux infections, en particulier aux maladies à transmission vectorielle, ce qui entraîne une morbidité et une mortalité maternelles et des résultats défavorables pour le fœtus e Les nouveau-nés ont une capacité limitée de thermorégulation e L'insécurité alimentaire pendant la grossesse est un facteur de risque de morbidité sur la femme et le fœtus e Les températures élevées peuvent avoir des eeffets néfastes sur la santé maternelle, du fœtu s et du nouveau-né Cours de préparation à la naissance en réponse aux effets du dérèglement climatique à Madagascar Cours de préparation à la naissance au CSBU* d’Ambanja Extrait d’une fiche du cours sur la préparation à la naissance e en malgache Aurore Raveloson , Nutsa Chikvaidze , Adhelia Tsizandry , Giovanna Stancanelli , Voahirana Rabakomahefa , Manjary Paulin Ramasy , Hasina Rasolondraibe , Cecilia Capello , Emma Vogel , Fabienne Tringa Fianakaviana Sambatrafisa (FISA), Enfants du Monde, Terre Innovative Healthcare, Ministère de la santé Publique 1 2 3 3 1 4 4 2 2 2 1 2 3 4 Encourager les femmes à adopte r un comporteme nt favorable pour l eur santé pendan t la grossesse et après l’accouch ement afin de rédu ire les e ffets du dé règlement climatiqu e sur leur santé et celle de leurs nouveau-nés Cours de préparation à la naissance pour les femmes enceintes :  Plus de dix séances d’approfondissemen t sur différents thèm es de santé, qui ont l ieu après la visite prénatale. e Ces séances se déroulent en peti t groupe (5-8 femmes) Un flyer avec les informations clefs es t donné aux femmes Plus informées, les femmes : S’alimentent mieux Vont d’avantage aux consultations prénatales Accouchent dans un centre de santé Réagissent de manière adéquate en cas de signe s alarmants Prennent soin de leur bébé de manière adaptée  Dès lors, les femmes sont mieux prises en charge et les risques sur la santé de la femme, du fœtus, du nouveau-né liés au dérèglement climatique sont mitigés. PROBLÈMES OBJECTIFS SOLUTIONS RÉSULTATS ©Terre innovative GROUPE D’ÉCHANGE AVEC LES SAGES-FEMMES LES SUJETS TRAITÉS LORS DU COURS DE PRÉPARATION À LA NAISSANCE Enfants du Monde https://edm.ch


BACKGROUND Health care systems are aware of the importance of being responsive to citizens’ expectations and needs. There are many efforts across Europe to measure the progress of health care systems’ responsiveness. One measure that could inform on how successfully we are closing the gap between citizens’ expectations of care and the actual health care provided is that of a patient’s assessment of their consultation with a doctor. However, there are yet many shortcomings on the linkages between patients’ perception of the quality of a consultation and their experiences of care, and these may vary with patients’ characteristics. OBJECTIVE To explore determinants of patients’ overall perception of the quality of an outpatient consultation in Hungary, with special focus on health status and measures of the care experience. METHODS § Cross-sectional online survey among a representative sample (n=1000) of Hungary’s adult population. Focus on a subsample (n=732) that have had an outpatient consultation in the past 12 months. § Overall perception of the quality of the consultation was measured with a 5-item scale (very poor/poor/good/very good/excellent). For regression purposes, the bottom two categories were merged. § Respondents’ characteristics, self-reported health (very bad/bad/fair/good/very good), EQ-5D-5L (the value set for England was used), EQ VAS, and type of provider (GP/specialist/allied health professional; public/private) were recorded. § Patient-reported experience measures (PREMs) recommended by the OECD (a doctor spending enough time in consultation, providing easy to understand explanation, giving opportunity to ask questions, patient involvement in decision making, and waiting times) were applied. § Ordinal logistic regression was used to explore associations between overall perception of the quality of an outpatient consultation and PREMs, health measures and respondents’ characteristics. RESULTS § The median rating for the quality of the consultation was very good (average: 3.8, SD: 1.1). § Based on the ordinal logistic regression results (Table 1), respondents with fair or bad/very bad health were 26% and 20% less likely to rate the consultation as excellent, compared to those that have reported a very good health. § Those who have reported positive care experiences with 1) the doctor spending enough time in consultation (25%), 2) involvement in decision making (23%), 3) opportunity to ask questions (21%), and 4) provide easy to understand explanations (17%) were more likely to rate the consultation as excellent. § Waiting time at a doctor’s office was a significant predictor of poorer ratings (e.g. odds ratio = 0.4 for a waiting period between 30 – 60 minutes). Specialist consultations at private facilities were significantly more likely to receive better ratings. IMPLICATIONS Respondents’ self-reported health status and experiences of care were found to be important determinants of the overall perception of the quality of an outpatient consultation, in Hungary. Positive experiences of care with the time a doctor spends in the consultation and the extent to which patients are involved in decision making contributed most to the overall perception of the quality of the consultation. Conversely, waiting time at a doctors office had a significant negative effect on patients’ perception of the quality of the consultation. These aspects deserve priority when planning interventions to improve quality of care, within a value-based health care framework. Patients’ perception of the quality of consultations modelled by patient-reported experience and health-related quality of life measures Monday, Nov 4, 2019 Research Poster Session 1 (10:30 – 14:00) PNS397 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 765141. Innovative Training Network for Healthcare Performance Intelligence Professionals Covariate OR CI Sociodemographic Sex (1: Wo


TOI-1135: Sub-Saturns are Universally Misaligned Emma Dugan, Xian-Yu Wang, Songhu Wang Indiana University, Bloomington, IN Introduction The Solar System exhibits several planets well aligned with their host star, however studies of hot and warm Jupiters (HJs and WJs) have shown that exoplanets can sometimes be misaligned. From analyses HJs and WJs, it has been shown that HJs are more likely to be misaligned than WJs.1 Studying the obliquities of sub–Saturns will provide further insights as to which properties, such as stellar temperature, planet-to-star mass ratio, and stellar age affect the alignment of stellar systems. TOI-1135 is a hot sub-Saturn orbiting a hot, young star and is an excellent candidate for probing the question of how planetary mass affects a planet’s likelihood of being misaligned. Observations Photometric observations of TOI-1135 were conducted using the Transiting Exoplanet Survey Satellite (TESS) in sectors 14, 19, 20, 26, 40, 47,53, 59, and 74.2 17 total spectroscopic measurements of TOI-1135 were collected using the High-Resolution mode (R ∼ 110, 000) of the NEID spectrograph. on the WIYN 3.5m telescope at Kitt Peak National Observatory.3 Top Figure: RM measurements and model residuals. Best-ﬁtted model is shown by red-dashed line, and uncertainty is represented by gray shadow. Left Figure: Stellar effective temperature vs projected spin-orbit misalignment for both isolated sub-Saturns and sub-Saturns in compact multi-planet systems, as well as Jupiters. Analysis To derive the sky-projected spin-orbit angle, we used allesfitter4 to perform a simultaneous global ﬁt to the Rossiter-McLaughlin (RM) measurements from the NEID spectrograph, radial velocity (RV) measurements from the CARMENES spectrograph at the Calar Alto Observatory5, and the light curves obtained from TESS. From this analysis we determine the sky-projected spin-orbit angle for TOI-1135 is λ = 67.9+18.1 °. We performed a periodogram analysis on the TESS light curves for this system with transit data masked out to derive the stellar spin velocity and constrain the spin-orbit angle along the line-of-sight.6 This analysis obtained a stellar rotation rate of 5.13土0.5 days, which resulted in an obliquity of Ѱ = 70.01+12.67°. References 1Albrecht et al. 2022 2Ricker et al. 2014 3Detailed information available at https://neid.ipac.caltech.edu/docs/NEID -DRP/ 4Günther& Daylan 2019, 2021 5Mallorquín et al. 2024 6Masuda & Winn 2020 Discussion TOI-1135 is a hot sub-Saturn which is misaligned relative to its stellar host. Since there are far fewer obliquity measurements for sub-Saturns than there are for HJs and WJs, every measurement of sub-Saturns provides valuable information regarding which factors encourage misalignment. As shown in the lower left plot, sub-Saturns exhibit misalignment across a wide range of stellar effective temperatures. This correlation with stellar temperature provides a piece of the puzzle that is vital for evidence of tidal realignment. From this obliquity measurement of TOI-1135, we ﬁnd further evidence that isolated planets are more likely to be misaligned than compact multis, as well as less massive planets are more likely to be misaligned than more massive planets, regardless of stellar temperature. -13.2 -16.5 My Website


Myriophyllum aquaticum Penița apei Familia Haloragaceae, Clasa Magnoliopsida Plantă perenă acvatică care formează mase dense de tulpini maronii (rizomi) împletite în apă. Rizomii funcționează ca o structură de sprijin pentru rădăcinile adventive și asigură ﬂotabilitate pentru creșterea emergentă din timpul verii. Tulpinile și frunzele emergente se extind de la câțiva zeci de centimetri deasupra suprafeței apelor. Tulpina are 40-90 cm lungime, ﬂexibilă, cilindrică, fără perișori și de culoare verde. Frunzele submerse sunt rotunjite la vârf, iar frunzele emergente sunt glauce și cu vârf scurt apiculat. Florile sunt situate în axilele frunzelor emergente superioare; sunt unisexuate. Florile bărbă- tești la început sunt sesile, iar în anteză au pediceli de până la 4 mm lungime; petalele sunt în număr de patru, de culoare galbenă, stamine în număr de 8. Florile femeiești au patru sepale albe, patru stile cu stigmate albe, dens ﬁmbriate și un ovar piriform (Arshid et al. 2016). De obicei, înﬂorește primăvara, dar unele plante pot înﬂori și toamna. Foto credit: https://www.web.forumacvarist.ro/myriophyllum-aquaticum/ ; https://garden.org/plants/view/77877/Parrot-Feather-Myriophyllum-aquaticum/ Flori Specie de interes pentru UE


In silico cholinergic pathway analysis indicates possible role for exogenous choline in modulating sensory processing in autism spectrum disorder Audrey Olson1,2, MS; Fuquan Zhang3, PhD; Hongbao Cao1,4, PhD; Ancha Baranova1, PhD; Margaret Slavin2, PhD, RDN 1Department of Bioinformatics and Computational Biology, School of Systems Biology, College of Science, George Mason University, Manassas, VA; 2Department of Nutrition and Food Studies, College of Health and Human Services, George Mason University, Fairfax VA; 3Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China; 4Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, China 1. Ashburner et al. Gene ontology: tool for the unification of biology. Nat Genet. May 2000; 25(1):25-9. http://geneontology.org/ 2. The Gene Ontology Consortium. The Gene Ontology Resource: 20 years and still GOing strong. Nucleic Acids Res. Jan 2019; 47(D1):D330-D338. http://geneontology.org/ 3. Liu, S., Rao, S., Xu, Y. et al. Identifying common genome-wide risk genes for major psychiatric traits. Hum Genet 139, 185–198 (2020). https://doi- org.mutex.gmu.edu/10.1007/s00439-019-02096-4 4. Molecular Signatures Database, MSig-DB, https://www.gsea-msigdb.org/gsea/msigdb 5. Elsevier’s Pathway Studio https://www.elsevier.com/solutions/pathway-studio-biological-research 6. Oliveros, J.C. (2007-2015) Venny. An interactive tool for comparing lists with Venn's diagrams. https://bioinfogp.cnb.csic.es/tools/venny/index.html o Sensory processing dysfunction is common in ASD. o Sensory processing relies upon sensory gating – ligand-activated, ion-channel- mediated pathways built upon cholinergic signals. o Acetylcholine plays roles in sensory processing, including auditory signal pathways, as well as cognitive function, memory, and learning. o Gene set enrichment analysis was conducted to identify Gene Ontology database1,2 pathways shared between MSig-DB curated cholinergic pathway gene sets (345 genes total) and a set of 53 autism genes identified by meta-analysis of genome- wide association studies3,4. o Ontologies associated with both the autism GWAS set and the MSig-DB functional pathway sets were identified using gene ontology association analysis within Pathway Studio (Elsevier)5. The lists of ontologies assigned to each of these gene sets were trimmed at approximately the lowest 100 p-values (p <0.01), while using a shift in p-value order of magnitude as the final determinant in list cutoff. o The gene ontology lists’ respective areas of overlap were identified using Venny6. o Associated pathways and ontologies were integrated graphically, using Pathway Studio to both illustrate and model the potential influence of dietary choline deficiency sensory pathways affected in autism. o To investigate a potential role of dietary choline intake as a means for bolstering sensory processing function, through use of scientific literature analysis using natural language processing (NLP) as a means for assessing potential gene ontological overlap between autism spectrum disorder (ASD) associated genes and cholinergic signaling pathways. o Because acetylcholine has long been identified as a modulator of ion transport throughout the body, the findings highlight a potential use for adequate dietary choline intake as a means to bolster acetylcholine supply, and therefore, ion transport related functionality across sensory domains. o Future study of sensory processing associated with autism should not only include identified genetic components, but also associated sensory processing pathway components, including acetylcholine, and its exogenous precursor, dietary choline. This project was funded by a research grant from the American Egg Board / Egg Nutrition Center. OBJECTIVES BACKGROUND METHODS RESULTS CONCLUSIONS ACKNOWLEDGEMENTS REFERENCES Figure 3. Subsequent analysis was conducted within Pathway Studio


●Scans should follow Library of Congress standards optimized for text and image extraction ●PDF with correct metadata and OCR quality should be provided before enhancing the annotation for a semantic publication. Contact Rainer Krug University of Zurich, Zürich, Switzerland rainer.krug@ieu.uzh.ch CC-BY - Plazi/Berlin, June 16, 2024 312848 308454 Semantic publications “Provide a way for computers to understand the structure and even the meaning of the published information, making information search and data integration more efficient” Wikipedia * All icons used in this poster are made available online for open use through an assortment of CC licenses SEMANTICALLY ENRICHED PUBLICATIONS - THE WHAT, HOW, AND HOW IT CHANGES RESEARCH D. Agosti1, R.M. Krug2, L. Bénichou3, F. Rinaldi4, P. Ruch5, R. Waterhouse6 1Plazi, Bern, Switzerland; 2University of Zurich, Department of Evolutionary Biology and Environmental Studies, Zürich, Switzerland; 3Museum National d'Histoire Naturelle, Science Press, Paris, France; 4Dalle Molle Institute for Artificial Intelligence, Lugano-Viganello, Switzerland; 5SIB Swiss Institute of Bioinformatics, SIBiLS, Carouge 6 SIB Swiss Institute of BioinformaticsEnvironmental Bioinformatics Group, Lausanne, Switzerland. How does it change research? Access to repositories including full text machine actionable articles and data allows analyses of Millions of documents at once, as seen in BiodiversityPMC and BiotXplorer. Introduction Publications are published, apart from promoting the authors career, to disseminate knowledge. In classic models, the publication consists of the text itself plus very limited metadata. Finding publications is usually done by metadata, keyword and full text searches (e.g. using OpenAlex). This produces many false positive results. Semantically (enriched) publishing adds additional context to the paper and therefore makes it easier and more accurate to find publications in a given topic, taxon, location, etc. This makes existing approaches to literature review more accurate and additional approaches possible. 190 SCICOM_15.1_637 Publications should include semantic tagging and persistent unique identifiers, allowing the creation of FAIR data for treatments, material citations, gene sequences, and other named entities of value for biodiversity research. Taxonomic concept and taxon name usages should be presented in a format that can be automatically harvested by the Catalogue of Life, GBIF or other indexers to contribute building an authoritative list of the world’s species. Printed Publication Printed Publication with Metadata Scan-Based PDF with Metadata Text-based PDF with Metadata ASCI-Standard Structured XML with Metadata ASCI-XML with Semantic Enhancements and Metadata, FAIR data ASCI-XML with Semantic Enhancements, Attributes and Metadata Legacy Publications Prospective Publications ●Should be machine readable by being published in highly structured and semantically enriched XML. How to create semantically enhanced publications? Semantic enhanced publications can be produced during the publishing process using reference schemas and vocabularies (e.g. JATS, or Darwin Core) demonstrated by Pensoft and European Journal of Taxonomy) or conversion of legacy, printed or PDF publications. Recommendations DOI: 10.5281/zenodo.11802785 DOI DOI DOI <tp:taxon-treatment> <tp:nomenclature> <tp:taxon-name> <tp:taxon-name-part taxon-name-part-type="genus" reg="Sinoluperus"> Sinoluperus</tp:taxon-name-part> <tp:taxon-name-part taxon-name-part-type="species" reg="subcostatus"> subcostatus</tp:taxon-name-part> </tp:taxon-name> </tp:nomenclature> </tp:taxon-treatment> Reference vocabulary (Taxpub) Annotation Attribute FAIRitization of data in publications Provide data in publications, such as treatments, figures, recommendations, conclusion as FAIR data. See for example publications in the Biodiversity Literature Repository. CC-BY-SA https://pt.m.wikipedia.org/wiki/Ficheiro:FAIR_data_principles.jpg


ATEE Spring Conference 2024 – May 29ᵗʰ - June 1ˢᵗ, Bergamo Using Mixed reality applications for learning Math Mosè Colangelo & Sara Bagossi Università degli studi di Torino - Department of Mathematics Function Virtuality Function Virtuality is a Mixed Reality (MR) prototype designed as a dynamic learning environment , operational in both virtual and augmented reality. It has been designed to facilitate the exploration and understanding of two-variable mathemat ical functions through immersive visual representatio ns of surfaces. This tool enables users to interact di rectly with the virtual environment using hand ge stures, eliminating the need for traditional controllers. Such a prototype has been developed within the European Project TransEET - Transforming Education with Emerging Technologies. e A preview of Function Virtuality can be seen by scanning this QR code: Main design features Visualization The prototype offers a robust feature for visualizing mathematical functions, allowing users to input their ow n formulas or choose from a selection of pre-existi ng examples. It supports both parametric and explicit forms of function eequations, providing flexibility in displaying a variety o f mathematical expressions. Users can adjust parameters and domain ranges of the functions using real-time sliders and interactive dots , allowing them to observe the impact of these changes on the surfaces. Interaction Function Virtuality includes interactive print docks, where users can "print" surfaces and manipulate them within the virtual space. These manipulations include scaling, rotating, and repositioning the surfaces. e Music mode A music mode feature is integrated into the prototype, where the visualization of functions dynamically respond s to music frequencies and harmonies. Artificial Intelligence (AI) Users can generate specific surfaces within the virtual space using natural language voice commands. The artificial intelligence interprets these commands and creates the desired surfaces in real-time, simplifying the exploration of complex mathematical functions. e Research objectives Various studies on the use of Mixed Reality in Mathematics Education have demonstrated that this emerging technology can boost student engagement and interest, as well as enhance visualization and spatial abilities (Bulut & Borromeo Ferri, 2023; Lei et al., 2018).s This prototype has been developed to explore the potentialities of mixed reality for eenhancing the understanding and visualization of mathematical functions. The primary objectives include: Investigating how immersive environments can support the understanding of complex mathematical concepts; Assessing the effectiveness of interactive and dynamic visualizations in facilitating learning; Exploring the integration of AI and natural language processing to simplify user interaction with mathematical tools. References Bulut, M., & Borromeo Ferri, R. (2023). A systematic literature review on augmented reality in Mathematics Education. European Journal of Science and Mathematics Education, 556–572. https://doi.org/10.30935/scimath/13124 Colangelo, M., Ghersi, A. & Soldano, C. (2024). Function Virtuality: a prototype of a learning environment on two variable functions. Workshop presented at CIEAEM 75 Restricted Meeting 22-24 April 2024. Torino, Italy. Lei, X., Zhang, A., Wang, B., & Rau, P.-L. P. (2018). Can Virtual Reality help children learn mathematics better? The application of VR headset in children’s discipline education. In P.-L. P. Rau (Ed.), Cross-Cultural Design. Applications in Cultural Heritage, Creativit y and Social Development. Springer International Publishing. https://doi.org/10.1007/978-3-319-92252-25 Trigueros, M., Orozco-Santiago, J., & Martinez-Planell, R. (2023). Learning two-variable functions using 3D dynamic geometry. Fourth conference of the International Network for Didactic Research in University Mathematics, Leibniz Universität Hannover. Acknowledgements This stu


Decision Context Approach Results Impacts Read-across is a popular data gap filling technique within category and analogue approaches for regulatory purposes. Acceptance of read-across remains a challenge with several efforts underway for identifying and addressing uncertainties. To date, these approaches have been qualitative in nature. Here, an algorithmic approach to facilitate read-across using ToxCast in vitro bioactivity data in conjunction with chemical descriptor information to predict in vivo outcomes in guideline (and guideline-like) testing studies from ToxRefDB is demonstrated. The read-across prediction for a given chemical is based on the similarity weighted endpoint outcomes of its nearest neighbors, calculated using in vitro bioactivity and chemical structure descriptors, called Generalized Read-across (GenRA). GenRA is a first step in systemizing read-across by providing performance metrics and enabling the scientific confidence of a prediction to be objectively assessed. References Disruptive Innovation in Chemical Evaluation Generalized Read-across (GenRA) prediction using chemical and biological information Imran Shah,1 Jie Liu,1,2,3 Richard S. Judson,1 Russell S. Thomas,1 Grace Patlewicz1* 1NCCT/ORD/US EPA, 2ORISE, 3UALR epa.gov/research CSS BoSC Meeting 2016 Presenting author: orcid.org/0000-0003-3863-9689| Grace Patlewicz l email: patlewicz.grace@epa.gov l I. Data 1,778 Chemicals 3,239 Structure descriptors (chm) 820 Bioactivity assays (bio) ToxCast 574 Apical outcomes (tox) ToxRefDB II. Define Local neighborhoods Use K-means analysis to group chemicals by similarity Use cluster stability analysis ~ 100 local neighborhoods III. GenRA Use GenRA to predict apical outcomes in local neighbor hoods Evaluate impact descriptors (chm, bio, bc) on prediction Quantify uncertainty Read-across acceptance is based on a subjective expert judgement assessment No objective means of assessing performance of a read-across Critical need for an objective measure of uncertainty in read-across prediction Data – Representing chemicals 1,778 Chemicals from ToxCast Phases I, II, III Each chemical represented by binary chemical (chm), bioactivity (bio) and toxicity (tox) vectors: 3,239 binary chemical structure descriptors (RDKit): Morgan fingerprints, Molecular Access System (MACCS) keys, and topological torsion fingerprints. Presence of structural feature denoted as “1” 820 binary bioactivity descriptors from ToxCast: If chemical is active in an assay then “1” else “0” 574 apical outcomes from ToxRefDB aggregated at the level of guideline study and target organ. If there is a significant effect at target site “1” else “0” Data –in vivo toxicity information from ToxRefDB Local neighborhoods (Clusters) α ij k j β j α ij k j α β, i s Σ x s Σ = y ghbours nearestnei = k Jaccard similarity: Impacts GenRA – performance in each cluster Use GenRA to predict the similarity weighted toxicity scores for each Toxicity type (𝛽𝛽) Descriptor ={chm,bio,bc} (α ) No. of nearest neighbours (𝑘𝑘) Similarity score threshold ( 𝑠𝑠𝑖𝑖𝑖𝑖 𝛼𝛼) Calculate performance by comparing predicted 𝑦𝑦𝑡𝑡𝑡𝑡𝑡𝑡and true 𝑥𝑥𝑡𝑡𝑡𝑡𝑡𝑡for all chemicals using area under ROC curve (AUC) Analyzing local neighborhood of a target chemical Comparing the read-across performance between different toxicity effects and their chemical representations Assessing the impact of the number of neighbors and the similarity threshold on the read-across prediction Bioactivity descriptors were often found to be more predictive of in vivo toxicity outcomes than chemical descriptors. Predictions were still context dependent on the endpoint and the chemical neighborhood under study. GenRA provides a first step in a tiered approach of investigating the utility of bioactivity data in concert with chemical structural information to make read-across predictions, and for systematically evaluating the uncertainty in those predictions. Next steps in progress: • Use of other chemical descriptor sets that encode


Innovative Research for a Sustainable Future www.epa.gov/research Concept Methods Results Additional Sources of Error Conclusion Replication of PBTK Models for Bisphenol A with High-Throughput TK Models Deep Compartment Clearance Compartment Chemical In Chemical Out Qhepatic Lung Blood Qcardiac Qliver Qgut Qrichly perfused Richly Perfused Blood Gut Blood Gut Lumen QGFR Richly Perfused Tissue Liver Blood Liver Tissue Qkidney Lung Tissue CLmetabolism Tissue Blood Kidney Tissue Qgut Arterial Blood Venous Blood Gut Tissue kgutabs Poorly Perfused Tissue Poorly Perfused Blood Doerge i.v. 0.1 mg/kg 1 comp. 2 comp pbtk Yang 2013 pbtk with Yang CL AFE 2.8 2.7 2.7 1.5 2.3 RMSE (nM) 27 24 24 53 22 • High-throughput toxicokinetics can inform the regulation of thousands of untested chemicals currently in use as a new alternative method to animal testing. • Several physiologically-based toxicokinetic (PBTK) models have been developed for Bisphenol A in human and rat. • These models involve extra-hepatic metabolism and contain additional compartments and clearances relative to a basic TK model with parameters fit to in vivo data. • In a high-throughput context, using minimal in vitro and in silico data, models such as these are not practical because of the inability to determine the necessary parameters for many chemicals. • Here we evaluate the performance of various levels of model complexity in the prediction of BPA TK. Chemical Out Compartment Chemical In • Three models from the R package ‘httk’, a PBTK, 2 compartment, and 1 compartment model, were compared against 2 human and 3 rat models from the literature, all evaluated against in vivo data. • Three of the rat studies used iv dosing, one simulating steady-state. The rest of the studies used oral dosing and single doses. • Literature models were translated to code and simulated where possible. • Root-mean-square-error (RMSE, the square root of the average squared difference in measured and predicted concentrations) and average fold error (AFE, the geometric mean of the quotient of the measured and predicted concentrations when the dividend is larger than the divisor) were used as metrics in the evaluation. • Non-restrictive clearance was used, where the total rather than free concentration is subject to clearance. • In the majority of cases, all ‘httk’ models predicted the in vivo data within an order of magnitude, with neither of the 2 compartment and pbtk models performing significantly better than the 1 compartment. Using the Yang et al. 2015 clearance value in rats, the pbtk model predicted the majority of data within a factor of 3. • In rats, the pbtk model predicted as well as the model in Yang et al. 2013 when using the same flow-limited clearance, both having AFE of 5.1, although in vivo measurements sometimes differed by more than a factor of 10 at the same time point. • A limited number of models were available for comparison due to poor reproducibility. • Depending on the necessary level of accuracy, simpler TK models successfully make predictions using limited in vitro and in silico data, with the advantage of greater reproducibility and fewer sources for error. • Enterohepatic recirculation is likely responsible for the changes in the effective elimination rate of the literature models, especially noticeable in rat. This requires additional modeling of the metabolites. • Models were not fully reproducible, due to lack of information or other problems. Many other BPA models could not be included in the analysis for this reason. Additionally, parameters were used in reproduced models not mentioned in the corresponding paper. • Compounds with very abnormal behavior such as PFOS and PFOA cannot be accurately predicted with high- throughput models. This poster dose not necessarily reflect EPA policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. 3201/P841 Human Evaluation Rat Steady State Evaluation Rat Single Dose Eva


Looking above the cloud deck of GJ 3470b Spandan Dash1, Matteo Brogi1,2 and Siddharth Gandhi3 1. Department of Physics, University of Warwick, Coventry, UK, CV47AL 2. Department of Physics, University of Turin, 1-10125 Torino, Italy 3. Leiden Observatory, Leiden University, Neils Bohrweg 2, 2333 CA, The Netherlands INTRODUCTION METHODOLOGY RESULTS and DISCUSSION REFERENCES GJ 3470b Properties • Neptune sized but slightly less massive (14 ME < 17.2 ME for Neptune) [4] • P = 3.88 days, Transit time = 1.918 hours [4] • Eccentric orbit – values of e vary quite a lot in literature – can go from slightly eccentric 0.017 to quite eccentric 0.114! [4] • Orbits an M-dwarf [4] but in a polar orbit [5] • Equilibrium temperature 600 K – Hence, warm Neptune – with evidence of clouds [1]. H2O detection but CH4 depletion[1] Fall due to Mie scattering? [1] High Resolution spectroscopy can look above a higher layer of clouds which proves difficult for low res! Figure reproduced from [2]. Figure reproduced from [1]. Spectra (time) Wavelength (pixel) Order 3D flux cuboid for each night Best fit H2O model to low resolution data Model Selection on a grid • ‘Goodness’ of a night is determined by whether we can detect 1x of an artificial exoplanet signal injected into the data. Possible using both nights of CARMENES by processing data between the ingress and egress phases. • Our best fit model to low res observations using just H2O and a cloud cover at 10-2.3 bar shows a detection (>5σ for Panel (e)) by combining both nights of observations with 1 times the best fit model injected in them. • In comparison, raw observations show no direct detection (Panel (f)) and prominent telluric contamination away from the exoplanet position. • Repeating the previous analysis for a grid of models will provide an estimate of how well a group of models are selected against the entire grid. Performing this on an isothermal grid with varying H2O abundances and cloud deck pressures results in both nights (Panels (e) and (f)) giving mostly consistent plots in terms of parameter selection. Combining nights strengthens the choice of selection to a strip of degenerate models, not all of which are in line with the finding in [1]. Combining 2 nights of observations with CARMENES does not show any direct detection of H2O above the cloud deck in the atmosphere of GJ 3470b. However, more good nights are necessary to conclude anything definite. A strong residual telluric feature also suggests the need for more aggressive detrending. Model Selection on an isothermal grid with varying H2O abundances and cloud deck pressures suggests a preference for a set of degenerate models with similar variances from the continuum which is wider than the finding from low resolution HST+Spitzer data. However, the grid assumed is not the same as previous studies and a more accurate grid of models with possible inclusion of two other molecules (CH4 and NH3) can be a potential solution to this non-conformity. This is currently being investigated. [1] Benneke, B., Knutson, H.A., Lothringer, J. et al. A sub-Neptune exoplanet with a low-metallicity methane-depleted atmosphere and Mie-scattering clouds. Nat Astron 3, 813–821 (2019). https://doi.org/10.1038/s41550-019-0800-5 [2] Siddharth Gandhi, Matteo Brogi, Rebecca K Webb, Seeing above the clouds with high-resolution spectroscopy, Monthly Notices of the Royal Astronomical Society, Volume 498, Issue 1, October 2020, Pages 194–204, https://doi.org/10.1093/mnras/staa2424 [3] Matteo Brogi and Michael R. Line 2019 AJ 157 114, https://doi.org/10.3847/1538-3881/aaffd3 [4] NASA Exoplanet Archive: https://exoplanetarchive.ipac.caltech.edu/overview/gj%203470b [5] Stefànsson, Guđmundur, et al. "The Warm Neptune GJ 3470b Has a Polar Orbit." The Astrophysical Journal Letters 931.2 (2022): L15 The figure above shows that detection of molecules with high res spectroscopy becomes much easier even at high cloud decks because the cores of molecular lines at high res


RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com OBJECTIVE The narrative perspective: The methods of empirical studies: Paired Samples Test before and after being exposed to HT narratives; Sample: 38 Ukrainian humanity students representing the youth as a vulnerable category (gender 87% of females); Case study: 35 media stories highlighted by anti- trafficking campaigns were analysed; respondents were exposed to 4 stories in the survey Hypothesis and variables: HT-stories transmit supportive and encouraging messages to victims that 1) survival is possible; 2) it is worth of struggling if anyone gets into slavery conditions; 3) social reintegration is possible. These variables are measured statistically. MATERIAL AND METHODS Results are significant for “social reintegration is possible” variable (Pair 5 and Pair 6): p<0.29; p<0.015 RESULTS CONCLUSIONS - No “happy-end” beliefs; no strong evidence for “survival is possible”, no confidence that it is worth struggling; + high level of tolerance manifesting in acceptance that social reintegration of victims is positive. KEY WORDS: human trafficking, media storytelling, monomyth, empirical study, survival stories To verify whether audiences believe in the happy end of survival stories on the human trafficking situation. Borys Grinchenko Kyiv University, Ukraine Elina Paliichuk ONCE UPON A TIME… : IS THERE A HAPPY END IN A HUMAN TRAFFICKING MEDIA STORY? Before After A. Narrative features of HT media stories: 1) simple narrative monomyth structure; 2) reiterated cyclic construal; 3) the 1st person narrative perspective; 4) connotative and figurative language passive voice for showing dependent state of victims. B. Reading perceptions: tone of stories C. Paired Samples Statistics D. “Which fragment impressed you most of all?” Fragment 1 I knew that if I didn’t leave now, I would not be able to keep my son safe. My life meant nothing to me but his life meant everything. I was 20 years old and pregnant by my pimp. The further I got along in my pregnancy, the less I was able to “work” (sell sex) and the more violent he became. At around 7 months, he beat me so severely I was taken to the hospital. It was clear I had experienced violence of some kind. My teeth had been kicked in and my face was bruised and bloody. Despite my visible injuries, I wasn’t sure what to say to the hospital staff when they asked me if I needed help. I knew the consequences of outing my pimp for what he was and I was scared of what would happen if I told them the truth. So instead, dropping my head to avoid eye contact, I just told them that I was fine and didn’t need help. I want other survivors who may be considering leaving but are not sure where to turn or who may be afraid to call the hotline to know this: Making that first call is scary but nothing changes if you don’t change something yourself. Fragment 2 After six long years trapped in the human trafficking networks that brought me to the United States – thanks to God – I got out alive. With the help of a good Samaritan, I’m now free from that world, where I was forced to sell my body. It wasn’t easy to leave. I tried to commit suicide several times, thinking that was my only way out. I wasn’t going to give my traffickers the pleasure of killing me – I would rather have done that myself. But my attempts were never successful, and only God knows why. One day, a stranger approached me in a public place and struck up a conversation. I ignored her at first because I was afraid to even speak to anyone. I felt like I was being watched by my traffickers at all times, no matter where I went, but this time that woman would change my life for the better. My story doesn’t end there. I’d survived human trafficking, but the emotional trauma buried me deep, and I needed psychiatric help to get out. However, I was able to recover and find the will and strength to go on living. As part of the process, I also had to overcome my fear of trusting people.