em530 channel (GFP) detected protein/TF, bound by anti-GFP background subtraction Integrating Gene Synthesis and Microﬂuidics for MC Blackburn, E Petrova, SJ Maerkl Institute of Bioengineering, School of Engineering, EPFL, Lausanne, Switzerland Literature 1) de Raad M, et al. A solid-phase platform for combinatorial and scarless multipart gene assembly. ACS Syn Bio 2013. 2) Lunqvist M, et al. Solid-phase cloning for hight- throughput assmebly of single and multiple DNA parts. NAR Vol 43(7), 2015. 3) Wolfe SA, et al. DNA Recognition by Cys2His2 zinc ﬁnger proteins. Annu. Rev. Biophys. Biomol. Struct., 1999. 4) Beerli RR, et al. Engineering polydactyl sinc-ﬁnger transcription factors. Nature Biotech, Vol 20, 2002. 5) Khalil AS, et al. A synthetic biology framework for programming eukaryotic transcription functions. Cell Vol 150, 2012. 6) Persikov AV, et al. Deep sequencing of large library selections allows computational discovery of diverse sets of zinc ﬁngers that bind common targets. NAR Vol 42 (3), 2014. 7) Persikov AV, et al. A systematic survey of the Cys2His2 zinc ﬁnger DNA-binding landscape. NAR, Vol 43(3), 2015. 8) Najafabadi H, et al. C2H2 zinc ﬁnger proteins greatly expand the human regulatory lexicon. Nature Biotech, 2015. 9) Fordyce PM, et al. De novo identiﬁcation and biophysical characterization of transcription-factor binding sites with microﬂuidic afﬁnity analysis. Nature Biotech Vol 28 (9), 2010. 10) Maerkl SJ, et al. A systems approach to measuring the binding energy landscapes of transcription factors. Science Vol 315, 2007. Introduction Projects ZF Modular Combinatorics ZF Speciﬁcity Engineering Methods Objective Engineering synthetic proteins with desired functions is difﬁcult. It can require multiple rounds of computational design, gene construction, expression and functional characterization to produce a new protein which consistently behaves in a novel, expected manner. Traditionally, these time and resource-consuming cycles involve gene synthesis via ligation or PCR-based assembly of DNA parts, cloning, and sequencing to ensure the gene coding for a given engineered protein is error-free1. This is followed by an assay to determine if the protein folds correctly and how effective the protein is at performing its intended function. A ligation/plasmid/cloning-free gene synthesis technique (detailed below) for rapidly constructing genes from synthetic DNA parts was coupled with a 1024- chamber MITOMI device for in vitro characterization of engineered zinc ﬁnger transcription factors. DNA parts were designed such that single ﬁnger modules could be interchanged with others, enabling the combinatorial construction of many different proteins from a small DNA pool. Engineering the binding speciﬁcity of individual zinc ﬁnger arrays through controlled amino acid substitutions was examined as a proof-of-concept for protein design. Solution Conceive of and build a platform for rapidly building genes from short, synthetic DNA oligomers (under 90 nt), examine the error rate of synthesis, and generate many ‘prototypes’ of proteins for a high-throughput functional screen. Apply this technique to several rounds of design > synthesis > expression > characterization to evolve a protein for a desired application. Zinc ﬁnger modules from zif268 and previously characterized5 arrays 37-12, 92-1 and 158-2 were used to generate novel zinc ﬁnger arrays. All ﬁngers in each position were interchanged and tested against a target library containing the expected consensus were each ZF behaving independently of the others in the same array. Zif268 (wt) N C ﬁnger 1 ﬁnger 2 ﬁnger 3 RSDELTR RSDHLTT RSDERKR C N RKREDSR TTLHDSR RTLEDSR 5'- aGCG TGG GCGt 6 5 4 3 2 1 -1 6 5 4 3 2 1 -1 6 5 4 3 2 1 -1 37-12 N C ﬁnger 1 ﬁnger 2 ﬁnger 3 RNFILQR DRANLRR RHDQLTR C N RTLQDHR RRLNARD RQLIFNR 5'- tGAG GAC GTGt 6 5 4 3 2 1 -1 6 5 4 3 2 1 -1 6 5 4 3 2 1 -1 158-2 N C ﬁnger 1 ﬁnger 2 ﬁnger 3 DKTKLRV VRHNLTR QSTSLQR C N RQLSTSQ RTLNHRV VRLKTKD 5'- tGTA GAT


CEDAR CENTER FOR EXPANDED DATA ANNOTATION AND RETRIEVAL SAP – a CEDAR-based pipeline for semantic annotation of biomedical metadata Ravi D. Shankar, Marcos Martinez-Romero, Martin J. O’ Connor, John Graybeal, Purvesh Khatri, Mark A. Musen Stanford University, Stanford, CA 94305, U.S.A. metadatacenter.org CEDAR is supported by grant U54 AI117925 awarded by the National Institute of Allergy and Infectious Diseases through funds provided by the trans-NIH Big Data to Knowledge (BD2K) initiative (www.bd2k.nih.gov) 11/2016 Under the umbrella of CEDAR metadata enrichment effort, we are building the Semantic Annotation Pipeline (SAP) that automates the semantic annotation of biomedical data stored in community data repositories. The pipeline has two major segments: 1) transform the metadata stored in the community data repository to CEDAR JSON-LD format, and 2) add semantic annotations to the CEDAR-formatted metadata. Annotated Metadata in CEDAR Repository Metadata in CEDAR Repository Metadata in Community Repository CEDAR Community Template NCBO BioPortal Ontologies MESH LOINC NCIT RXNORM CPT ICD10 PATO SNOMEDCT MEDDRA NCBITAXON DOID UO At the core of the Annotator is the Apache UIMA ConceptMapper, a named- entity recognition tool. The Annotator annotates metadata with ontology terms as speciﬁed in the template. The ontology terms are served by the NCBO BioPortal. The Ingestor transforms the metadata in the community repository to instances of a JSON- encoded CEDAR community template. The CEDAR Community Template encapsulates the metadata speciﬁc to that community. The template includes ontological information on value restrictions on speciﬁc metadata elements. Ingestor Annotator }, "sampleID": { "@value": "GSM1169960" }, "description": { "@value": "IPF" }, "tissue": { "@type": "http://ncicb.nci.nih.gov/ xml/owl/EVS/Thesaurus.owl#C12801", “@value": "Lung" }, "disease": { "@type": "http://ncicb.nci.nih.gov/ xml/owl/EVS/Thesaurus.owl#C7057", “@value": null }, ^SAMPLE = GSM1169960 !Sample_title = IPF23lung !Sample_type = RNA !Sample_source_name_ch1 = IPF !Sample_organism_ch1 = Homo sapiens !Sample_characteristics_ch1 = tissue: Lung !Sample_molecule_ch1 = total RNA !Sample_label_ch1 = biotin !Sample_description = IPF !Sample_label_protocol_ch1 = Biotinylated cRNA were prepared with the Ambion MessageAmp kit for Illumina arrays Ingestor Annotator An Illustration of SAP: Semantic Annotation of GEO Sample Metadata CEDAR GEO Sample Template GEO Sample Metadata in GEO Repository GEO Sample Metadata in CEDAR JSON-LD format Value Restrictions in CEDAR GEO Sample Template Semantically Annotated GEO Sample Metadata in CEDAR JSON-LD format }, "sampleID": { "@value": "GSM1169960" }, "description": { "@value": "IPF" }, "tissue": { "@type": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12801", "_valueLabel": "Lung Tissue", "@id": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33024" }, "disease": { "@type": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057", "_valueLabel": "Idiopathic Pulmonary Fibrosis", "@id": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35716" },


RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com Bell's palsy is a rapid unilateral facial nerve paresis (weakness) or paralysis (complete loss of movement) of unknown cause. The condition leads to the partial or complete inability to voluntarily move facial muscles on the affected side of the face. Although typically self-limited, the facial paresis/paralysis that occurs in Bell's palsy may cause significant temporary oral incompetence and an inability to close the eyelid, leading to potential eye injury. Additional long-term poor outcomes do occur and can be devastating to the patient.1 Immune, infective and ischaemic mechanisms are all potential contributors to the development of Bell's palsy, but the precise cause remains unclear.2 The aims of treatment in the acute phase of Bell's palsy include strategies to speed recovery and to prevent corneal complications. Eye care includes eye patching and lubrication. Strategies to speed recovery include physical therapy, corticosteroids and antiviral agents.3 Inactivated vaccines against SARS-CoV-2 are being developed by several vaccine manufacturers. The inactivated COVID-19 vaccine Sinovac CoronaVac was developed by Sinovac. CoronaVac has been authorized as a 2-dose vaccine for individuals aged 18 years and older. Systemic adverse effects include: fatigue, fever, myalgia, diarrhoea, headache, cough, nausea, and vomiting. Local side effects include: pain, pruritus, swelling, redness, and induration.4 INTRODUCTION METHOD REFERENCES 1) Reginald F. Baugh et al. Clinical Practice Guideline: Bell’s Palsy. American Academy of Otolaryngology—Head and Neck Surgery Foundation. 2013; 149(3S) Pg1. 2) Eviston TJ, et al. Bell's palsy: aetiology, clinical features and multidisciplinary care J Neurol Neurosurg Psychiatry. 2015 86: Pg1356-1361. 3) J. M. K. Murthy et al. Bell's palsy: Treatment guidelines. Ann Indian Acad Neurol. 2011 Jul; 14(Suppl1): S70–S72. 4) World Health Organisation. Background document on the inactivated vaccine Sinovac-CoronaVac against COVID-19. 2021: Pg 21. 5) Bin-Yan Yu et al. Bell’s palsy after inactivated COVID-19 vaccination in a patient with history of recurrent Bell’s palsy: A case report. World J Clin Cases. 2021 Sep 26; 9(27): Pg8274–8279. The above image to the left shows loss of nasolabial fold and drooping of the left mouth corner. The image to the right was taken after full recovery of Bell’s Palsy. Ophthalmology Department, Hospital Kuala Lumpur Thivakar S (MD), Fatin S (MS Opthal) Bell’s Palsy Post Administration of COVID-19 Inactivated Vaccine DISCUSSION CONCLUSION To report a case of Bell’s Palsy occurring post vaccination. AIM CASE REPORT Case report. A 23 years old Malay lady presented with left sided facial weakness over the past 2 weeks associated with occasional tearing over the left eye. She had no comorbids. Upon further questioning, it was noted that patient was administered her first dose of COVID- 19 vaccination 3 weeks ago, which was 1 week prior to her presentation to the Ophthalmology clinic. Upon general examination of the patient, it was noted that there was lagophthalmos over the left eye with poor Bell’s phenomenon. There was also loss of nasolabial fold over the left side of her face. Loss of frontal wrinkling as well as drooping of the left mouth corner was also noted. However there were no other cranial nerve involvement. Patient had no peripheral neurological deficits. Upon ocular examination, it was noted that right eye vision was 6/9 and her left eye vision was 6/24. No RAPD. Anterior segment of her right eye was unremarkable. Left eye anterior segment examination shows minimal superficial punctate keratopathy inferiorly at the cornea. Both eyes’ intraocular pressure was normal. Dilated fundus examination of both eye was unremarkable. As patient was referred from the ENT Department for the above complaints, patient was already started on Oral Mecobalamin and a tapering dose of Oral Prednisolone to be taken over


(http://dh2016.adho.org) DH Home (http://www.dh2016.adho.org) / Abstracts (/abstracts/) / 86 (/abstracts/86) Title: EVI-LINHD. A Virtual Research Environment for the Spanish-speaking Community Authors: Gimena del Rio Riande, Elena González-Blanco García, Clara Martínez Cantón, Juan José Escribano Category: Paper:Poster Keywords: Virtual Research Environment, Virtual Research Community, Digital Scholarly Edition, Spanish-speaking Community, DH Center Although Digital Humanities have been defined from a discipline perspective in many ways, it is surely a field still looking for its own objects, practices and methodologies. Their development in the Spanish-speaking countries is no exception to this process and, even it is complex to trace a unique genealogy to give account for the evolving field in Spain and Latin America (Gonzalez-Blanco, 2013; Spence and Gonzalez-Blanco, 2014; Rio Riande 2014a, 2014b), the emergence of various associations in Mexico (RedDH), Spain (HDH) and Argentina (AAHD) that seek for a constant dialogue (Galina, González-Blanco and Rio Riande, 2015), and academic lab and DH center initiatives such as LINHD (Spain and Argentina), GRINUGR (Spain), Medialab USAL, LABTEC (Argentina), TadeoLab (Colombia), Elabora HD (Mexico), among others, make it clear that research has become increasingly “global, multipolar and networked” (Llewellyn Smith, et al., 2011) and that the academic field is looking for a global outreach and aims to open spaces of shared virtual work. Virtual Research Communities (VRCs) are a consequence of these changes. Virtual Research Environments (VREs) have become central objects for digital humanist community, as they help global, interdisciplinary and networked research taking of profit of the changes in “data production, curation and (re‐)use, by new scientific methods, by changes in technology supply” (Voss and Procter, 2009: 174-90). DH Centers, labs or less formal structures such as associations benefit from many kind of VREs, as they facilitate researchers and users a place to develop, store, share and preserve their work, making it more visible. The focus and implementation of each of these VREs is different, as Carusi and Reimer (2010) show in their comparative analysis, but there are some common guidelines, philosophy and standards that are generally shared (as an example, see the Centernet map and guidelines of TGIR Huma-Num, 2015). This poster presents the structure and design of the VRE of LINHD, the Digital Innovation Lab at UNED ( http://linhd.uned.es (http://linhd.uned.es)), and the first Digital Humanities Center in Spain. This VRE focuses on the possibilities of a collaborative environment for (profane or advanced) Spanish-speakers scholarly digital editors. Taking into account the language barrier that English may suppose for a Spanish-speakers scholar or student and the distance they may encounter with the data and organization of the interface (in terms of computational knowledge) while facing a scholarly digital edition or collection, LINHD’s VRE comes as a solution for the VRC interested in scholarly digital work. Moreover, it will make it possible to add an apply tools that contribute to improve Spanish-English applications or tools developed locally, such as Contawords, by Iula-UPF http://contawords.iula.upf.edu/executions (http://contawords.iula.upf.edu/executions). Opening such an environment to the Spanish speaking world will make it possible to reach different kinds of communities, whose profile and training in digital humanities differ from the typical users of DH tools and environment. Testing all these tools in this new environment will, for sure, draw interesting project results. In this sense, our project dialogues and aims to join the landscape of other VREs devoted to digital edition, such as Textgrid, e-laborate, etc. and, in a further stage, to build a complete virtual environment to collect and classify data, tools and projects, work and publish them and s


Task/Result Queues ML-based drug screening Real-time crystallography You request a function be executed on endpoint A and B Federated Function as a Service ●Modern computing environments are distributed and heterogeneous; modern workloads require specialized hardware, rapid responses, and remote processing (e.g., near data) ●FaaS provides an intuitive interface for users to register and invoke programming functions without regard for underlying infrastructure ●Federated FaaS enables functions to be dispatched to remote endpoints chosen for data locality, security, or other concerns ●funcX allows users to execute Python functions (which may invoke executables, MPI programs, etc.) on arbitrary resources (e.g., CPUs, GPUs) from short to long run times from funcx.sdk.client import FuncXClient fxc = FuncXClient() Instantiate a funcX client Register Python function with input args Execute a function by specifying endpoint and input arguments Fire-and-forget execution Outsource the challenging aspects of remote execution funcX manages authentication, serialization of functions and data, reliable execution optionally in containers, and delivery of results back to requesting users Transform resources into FaaS endpoints Easily manage execution across distributed resources The funcX endpoint software can be deployed on laptops, clouds, clusters, and supercomputers. It provisions resources elastically based on workload. High performance Launch millions of tasks funcX supports batch submission and monitoring, asynchronous callbacks, container warming, automated resource scaling, fault tolerance, prefetching, and memoization Portable serverless computing to enable scalable data science def hello_world(): return "Hello World!" func_uuid = fxc.register_function(hello_world) ep_id = '4b116d3c-1703-4f8f-9f6f-39921e5864df' result = fxc.run(endpoint_id=ep_id, function_id=func_uuid) fxc.get_result(result) Retrieve results (and exceptions) asynchronously $ pip install funcx_endpoint $ funcx-endpoint configure $ funcx-endpoint start <ENDPOINT_NAME> Install and conﬁgure a funcX endpoint def compute(args): # do something return results (1) Registration (function + container) F(ep1,1) F(ep1, 2) F(ep1, 3) F(ep1, 4) F(ep1, 5) F(ep1, 6) (2) Execution (function, endpoint, args) A A 1 3 2 funcX manages the reliable and secure execution on those endpoints funcX notifies you when the function is complete funcX development has been supported by NSF 2004894/2004932 and an Argonne Lab Directed Research and Development award Try on Binder https://funcx.org/binder HEP fitting as a service Application examples Functions Endpoints Yadu Babuji*, Josh Bryan*⚑, Kyle Chard*⚑, Ryan Chard*⚑, Ben Clifford*, Ian Foster*⚑, Ben Galewsky°, Daniel S. Katz°, Kevin Hunter Kesling*, Zhuozhao Li*, Kirill Nagairtsev*, Stephen Rosen*, Tyler Skluzacek* *University of Chicago & Argonne National Laboratory; ⚑Globus; °National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign


<Fußzeile> 1 Das NFDI-Konsortium Text+ wird gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 460033370 www.text-plus.org Ressourcen Corpus Reader Natural Language Processing Pipeline MINE Modes of Narration and Attribution Event Tagger (Vauth, u. a. 2021) Comment Tagger (Weimer u. a., im Erscheinen) Generalization Tagger (Gödeke, im Erscheinen) Entity Linker (Barth u. a., 2022) Attribution Tagger (Dönicke u. a., 2022) Sprecher/Rede, Koreferenzresolution Speech Tagger (Brunner u. a. 2022) Speaker Extractor (Dönicke, u. a. 2022) Coref (Krug, u. a.; Dönicke, u. a. 2022) Semantische Analyse Temponym Tagger (Strötgen und Gertz, 2010 / 2015) Emotions Tagger (Mohammad und Turney, 2010; Dönicke, u. a. 2022) Morphosyntaktische Analyse Sentencizer (spaCy / NLTK) Dependency Parser (spaCy) Clausizer (Dönicke, 2020) Analyzer (Altinok, 2018) TenseTagger (Dönicke, 2020) Preprocessing Tokenizer (spaCy) Tagger (spaCy) Lemmatizer (spaCy) NER (spaCy) Normalizer (Dönicke, u. a. 2022) NLP-Pipeline MONAPipe (Dönicke u. a. 2022): • entwickelt im Projekt Modes of Narration and Attribution (MONA) innerhalb des Göttingen Centre for Digital Humanities (GCDH) • basierend auf spaCy 2 (Honnibal und Montani, 2017) • Standardkomponenten und Custom-Komponenten (Re- Implementierungen / Wrapper bestehender Systeme sowie Eigenentwicklungen) Anreicherung textinterner Strukturinformationen, u. a.: • linguistische Strukturen (Zeitformen, Zeitausdrücke, Sprachnormalisierung, Satz-/Teilsatzsplitting) • Named Entities (inkl. Koreferenzen sowie Entity Linking) • narrative Phänomene (Redewiedergabe, Sprechererkennung und -attribution, Ereignisse, Reflexionen) Florian Barth (SUB Göttingen / Göttingen Centre for Digital Humanities), José Calvo Tello (SUB Göttingen), Stefan Funk (SUB Göttingen), Mathias Göbel (SUB Göttingen), Daniel Kurzawe (SUB Göttingen), Nanette Rißler-Pipka (Gesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen), Ubbo Veentjer (SUB Göttingen) Sammlungen an der SUB Göttingen • das TextGrid Repository beinhaltet u. a. literarische Korpora (Digitale Bibliothek), digitale Editionen (Architrave, Bibliothek der Neologie) oder Digitalisate (Virtuelles Skriptorium St. Matthias) • DARIAH-DE Repository und Portal DiscussData als Plattformen für geisteswissenschaftliche Forschungsdaten • DigiZeitschriften, das deutsche digitale Zeitschriftenarchiv, umfasst wissenschaftliche Zeitschriftenbestände aus dem geisteswissenschaftlichen Bereich • im Verzeichnis deutschsprachiger Drucke des 17. sowie des 18. Jahrhunderts (VD17, VD18) werden vom Göttinger Digitalisierungszentrum und nationalen Partnern alle Druckwerke der entsprechenden Jahrhunderte digitalisiert VD17 VD18 Unstrukturierter Text Unterschiedlicher Stand der Digitalisierung und textinternen Anreicherung in SUB-Ressourcen: • Texte mit umfassenden Strukturinformationen • Plain-Texte mit schwankender OCR-Qualität • als Bilddateien digitalisierte Faksimiles (VD17, VD18) Ziele • Erzeugung qualitativ hochwertiger Plain-Texte für Ressourcen mit Bilddateien in Zusammenarbeit mit dem OCR-D-Projekt • Text-Mining-Verfahren zur Anreicherung mit textinterner Struktur • Bereitstellung abgeleiteter Textformate (Schöch u. a. 2020) Import • Ingest kompletter Sammlungen (Text und Metadaten) • Support für spezifische Daten- und Metadatenformate, z. B. TEI-XML- Varianten von Community- relevanten Korpora Anreicherung • Data Reconciliation: Überprüfung, Vervollständigung und Erweiterung der Metadaten • Enrichment: Verknüpfung der Metadaten mit Normdaten und Knowledge Bases Export • Serialisierung angereicherter Metadaten in gewünschtes Format (Eingangsformat oder Neuformat) KOLIMO VIAF • Data Warehouse normalisierte Einbindung distinkter Ressourcen • Elastic Search Repository-übergreifende Suche für Text und Metadaten • Knowledge Graph (neo4j) Ressourcen-übergreifende Verknüpfung von Informationen auf Dokumentebene und textinternen Anreicherungen Task Area Collections Text-Mining-Pipelines fü


Field plots were established in Knoxville, TN (latitude 35.971438, longitude -83.854094) on the East TN Research and Education Center, Holston River Unit. Differing levels of weed populations were created in a 4.5 ha field by herbicide application in year 1. Primary weeds were Xanthium strumarium and Urochloa platyphylla Variable rate applications (VRAs) of atrazine preemergence (PRE) followed by dicamba postemergence (POST) were investigated for the reduction of herbicide inputs and their resulting impact on weed control and corn yield. VRAs of atrazine were on the basis of weed density data collected in Year 1. VRAs of dicamba (Banvel) were based upon common cocklebur density evaluations within the field. Technical support provided by John B Wilkerson and William E Hart was appreciated. This research was conducted on research farms associated with the Tennessee Agricultural Experiment Station, a division of the University of Tennessee Institute of Agriculture. 1.Compared with conventional applications, atrazine usage was decreased by 43 and 32% in the site-specific application treatments in Year 2 and Year 3, respectively. 2.VRAs of dicamba reduced herbicide inputs by greater than 45% for Year 2 and Year 3. 3.Corn yields were similar for the conventional and site- specific treatments in both years. This research compared site- specific weed control using variable rate herbicide dosing to broadcast applications under field conditions in a maize production field in Tennessee, USA. On the basis of these data, site- specific herbicide applications have the greatest potential and least risk for managing weeds when POST or PRE + POST variable rate herbicide applications are used. Yields in site-specific plots were equal to using broadcast sprays. Site-specific weed management can increase crop production efficiency by minimizing herbicide input costs without compromising crop yields. A reduction in herbicide inputs resulting from site-specific weed management may also decrease the probability of nonpoint pollution compared with conventional herbicide applications.


Plasticrusts and pyroplastic: two novel plastic debris types detected in Giglio island, Italy Julius A. Ellrich1 & Sonja M. Ehlers2,3 1Julius_Ellrich@web.de; Independent Researcher, Sankt-Josef-Straße 25, 56068 Koblenz, Germany 2Ehlers@bafg.de; Department of Animal Ecology, Federal Institute of Hydrology, Am Mainzer Tor 1, 56068 Koblenz, Germany 3Institute for Integrated Natural Sciences, University of Koblenz-Landau, 56070 Koblenz, Germany www.juliusaellrich.weebly.com, www.sonjamehlers.weebly.com REFERENCES: Ehlers SM & Ellrich JA 2020. First record of plasticrusts and pyroplastic from the Mediteranean Sea. Marine Pollution Bulletin 151: 110845. Doi: 10.1016/jmarpolbul. 2019.110845 INTRODUCTION: Fig.1A)LocationofGiglioislandintheTyrrhenianSea.B)Locationsofthefivesurveyed habitats (H1-H5) in Giglio. H2 and H3 were adjacent habitats and, thus, depicted by a singledot.C)Thewave-exposedrockyshore(H1).D)Thewave-shelteredbeach(H2). METHODS: Inthefield,wemeasuredplasticrustdensity,areaandpercentcoverusing quadrats(10 cm x 10 cm). At the lab, we determined plasticrust thickness using a digital microscope and pyroplastic size using digital calipers. Furthermore, we identified the plasticrust and pyroplastic materials (i.e., polymer types) with Fourier-transform infrared spectroscopy (FTIR, Fig. 2). We conducted our FTIR measurements in attenuated total reflectance (ATR) mode in a wavenumber range between 4000 and 370 cm−1with 8 co- added scans and a spectral resolution of 4 cm−1. Then, we compared the obtained spectrawiththeBrukerspectrallibraryinOpus7.5software. Plasticrusts and pyroplastic are novel plastic debris types that have only recently been reported for the first time from Madeira island (Atlantic Ocean, Gestoso et al. 2019) and the southern United Kingdom, respectively (Turner et al. 2019). While plasticrusts result from plastic debris being wave-swept across rugose rocks, pyroplastics derive from burnt plastic waste. During field surveys in Giglio island (Tyrrhenian Sea, Italy), we detected plasticrusts on a wave-exposed rocky shore and pyroplasticonawave-shelteredsandybeach(Ehlers&Ellrich2020,Fig.1). Fig. 2 Sonja M. Ehlers identifying polymer types using FTIR (Vertex 70, Bruker, Ettlingen, Germany) at the Federal Institute of Hydrology in Koblenz, Germany. C D Plasticrust (Fig. 3A) density was 3.25 ± 1.65 plasticrusts/dm2 (mean ± SE; n= 4 quadrats). Plasticrust area was 0.46 ± 0.08 mm2 (n= 13 plasticrusts). Plasticrust cover was 0.02 ± 0.01 % (n= 4 quadrats). Plasticrust thickness ranged between 0.5 and 0.7 mm. FTIR analyses revealed the plasticrust material as polyethylene (PE, Fig. 3B). We didnotdetectanyplasticrustsonthewave-shelteredrockyshores(H3-H5,Fig.1B). ACKNOWLEDGEMENTS: We thank Professor Dr Jochen H. E. Koop for letting us use the FTIR spectrometer at the Federal Institute of Hydrology in Koblenz, Germany. RESULTS: Fig. 3 A) The detected blue plasticrusts consisted of (B) PE material. Fig. 4 A) The detected pyroplastic with blue inclusions. B) Pyroplastic close-up. C) The FTIR spectrum that revealed PET as the pyroplastic material. D) PET bottle found on the beach (H2, Fig. 1B). E) The FTIR spectrum that confirmed PET as the bottle material. The pyroplastic had a stone-like appearance (Fig. 4A) with blue inclusions (Fig. 4B). Pyroplastic size was approximately 2 cm × 1.4 cm × 0.5 cm (length x width x height). FTIR analyses showed that the pyroplastic material was polyethylene terephthalate (PET, Fig. 4C). On the beach, we detected burnt charcoal near the pyroplastic. Finally, wefoundseveralPETbeveragebottles(Fig.4D, E)ineachhabitat(H1-H5,Fig.1B). DISCUSSION: A B Absorbance units Wavenumber (cm-1) FTIR measurement spectrum Bruker library spectrum A B D E Wavenumber (cm-1) C Absorbance units Absorbance units Wavenumber (cm-1) FTIR measurement spectrum Bruker library spectrum FTIR measurement spectrum Bruker library spectrum Our results from Giglio resemble findings from Madeira and the United Kingdom indicating


日本語における対のある自他動詞の習得 ―中国人学習者の場合― 王冠亮（南山大学大学院生）・坂本正（南山大学） 従来の対のある自他動詞に関す る習得研究の結論の一つは、学習 者にとって自動詞の習得が難しく、 特に結果状態が注目される自動詞 文の習得が難しいということである （守屋1994;小林･直井1996;小林 1996;王2012;伊藤2012; ）。 はじめに 先行研究の問題点 1 結果状態が注目される自動詞 文に関する問題項目が少ない。 2 パーセンテージ（％）が主な手 法で、結果は一般化しにくい。信頼性がどれぐらいある？母集団については？ 本研究の研究課題 結果状態が注目される自動詞文 の習得は果たして難しいか 本研究の研究仮説先行研究の結果を検証しなおす とともに、三つの仮説を立てる H1 動作主特定･非特定は自他 動詞の選択に影響がある。 H2 文の肯定・否定は学習者の 自他動詞の選択に影響があ る。 H3 自他の３つの派生パターン は自他動詞の選択に影響が ある。 H1を立てる理由 守屋（1994）と杉村（2013）などの 研究において，対のある自他動詞 の習得難易度には，「動作主の特 定・不特定」が一つの目安、要因と して取り上げられている。 H2を立てる理由 部分の研究は対のある自動詞で 成り立つ「結果（無標）可能表現」が 学習者に難しいと主張している。 しかし、これらの研究で使われる 調査問題は100％否定文である。 H3を立てる理由 一般的に日本語の自他交替を自 動化・他動化・両極化が取り上げら れてきたが，自他交替に三つのパ ターンがあることが学習者の習得 に影響を及ぼすのか。これ、本当？肯定文、やさしい？検証する！ 調査 調査の実施 調査期間：2016年4月25日—29日・ 9月26日—10月07日 調査場所：中国安徽省にあるS大学 とN大学，並びに，日本南山大学 調査対象： S大学三年生（S3）26人 N大学二年生（N2）31人 N大学三年生（N3）35人，計92人 （回収有効調査票は85部） 日本人大学生（JP）30人 調査の設計 1 学習者の既習語彙を使用 2 研究課題と仮説を中心に24問を 用意 3 五つの選択肢のある多肢選択問 題を使う 4 文脈情報を学習者の母語で提供 グループ 平均正答率 mean 標準偏差 sd S3 62.86 19.74 N2 56.95 20.94 N3 52.34 16.53 JP 94.86 10.36 調査の結果（記述統計量） 各組の正答率の箱ひげ図 結論 研究課題 Kruskal-Wallis検定で4群を比べる。 H(3)=62.04,η2=.54,p＝2.152e-13 四群に有意差があり、 続いて多重比較 学習者の間に有意差がない。 JP－S3: r=.74, p=4.0e-08 JP－N2: r=.73, p=7.7e-09 JP－N3: r=.82, p=6.5e-11 結果状態が注目される自動詞文が難しい！ 研究仮説１ N2:t(29)=0.57, d=.10 ,p=.57 N3: V=212.5, r=.03 , p=.84→ノンパラ S3: t(22)=0.32, d=.07 , p=.75 三群いずれも有意差が見られな かったので、動作主特定･不特定が 学習者に影響を与えるとは言えない！ 研究仮説２ N2:t(29)=.84,d=.16, p=.40 N3: t(31)=.90,d=.16,p=.37 S3: V=130,r=.01,p=.92→ノンパラ 三群いずれも有意差が見られな かったので、文の肯定･否定が学習 者に影響を与えるとは言えない！ 研究仮説３ N2:F(2,87)=0.285,MS=178.8 η2＝.01 ,p=.75, N3: χ2（2）＝0.39,p=.82→ノンパラ S3: χ2（2）＝4.963,p=.08→ノンパラ 三群いずれも有意差が見られな かったので、派生パターンが学習者 に影響を与えるとは言えない！ 第27回第二言語習得研究会全国大会 2016年12月18日於九州大学 参考文献（予稿集にない部分） （1）伊藤秀明（2012b）「相対自動詞･他動詞選択判断の要因―中国人大学生の場合―」『国際交流基金日本語教 育紀要』8,7-21.独立行政法人国際交流基金. （2）大友賢二･中村洋一（2002）『テストで言語能力は測れるか－言語テストデータ分析入門－』桐原書店 （3）奥津敬一郎（1967）「自動化・他動化および両極化転形―自・他動詞の対応―」須賀一好・早津恵美子［編］ （1995）『動詞の自他』ひつじ書房 （4）王冠华（2012）「中国日语学习者有对自动词习得状况的实证研究」『日语学习与研究』5，86-94,对外 经济贸易大学. （5）王恰韓（2012）「中国人学習者における日本語無標可能表現の習得に関する研究: この役はあの新人俳優 にはつとまらない」『日本語研究』32，1-14,首都大学東京・東京都立大学日本語・日本語教育研究会. （6）関承（2014）『中国語母語話者における日本語自・他動詞の習得研究―中国語で可能標識が使われる表現を 中心に―』広島大学未公刊博士学位論文 （7）小林典子（1996）「相対自動詞による結果・状態表現―日本語学習者の習得状況― 」 『文芸言語研究・言語篇』29, 41-56,筑波大学. （8）封小芹（2007）「可能の意味を含む有対自動詞の受容能力の習得について- 中国人日 本語学習者の場合- 」『ククロス:国際コミュニケーション論集』4，49-63,名古屋大学. （9）張威（1992）「『可能表現の本質』考：無標の可能表現へのアプローチ」『中京大学教養 論叢』32(4)，1351-1373, 中京大学.


Shifting Terms and Concepts: From Defence to (Human) Security Introduction Over the last two decades, the concepts of defence and security have overlapped to the point where the former is merged with the latter. Since jihadist terrorism broke out at the dawn of the millennium, governments have been forced to review the classic paradigm according to which the military is employed in overseas operations—or the defence of the homeland from external enemies—and police and law enforcement agencies are tasked with internal security. In such a context, the military has taken on an increasing role in national security matters, although security itself is an umbrella concept under development that currently includes such cross- cutting topics as terrorism, cyber threats, health, food, energy, the economy, poverty, climate change, information technology, social security, job security, just to mention a few. The inclination to replace the idea of defence with security has contributed to the expansion of the idea of security itself. This way, defence activities abroad, such as military assistance to Ukraine in the context of the ongoing conflict with Russia, are presented to the public as "security" operations. Data analysis The author of this work has checked the multi-sectoral approach to security outlined by the UN and the NATO against commonly accepted versions of human security through a comparative study of the definitions provided by well-established and reputable dictionaries such as Merriam-Webster, Britannica, Collins, Oxford, Cambridge, Longman, and Macmillan. Such dictionaries provide similar definitions of the term "security": safety; safety from attack, harm, or damage; freedom from danger or threat; freedom from fear or anxiety; being safe and free from worry; being protected or safe from harm. Security is the protection from, or resilience against, the potential harm caused by others by restricting one's freedom to act. Conclusions The human security approach broadens the scope of security analysis and policy from the traditional notion of national security to the security of people and their complex social and economic interactions. The term "defence", is given as a synonym of "security" by the majority of these dictionaries (Merriam-Webster, Cambridge, Oxford, Collins), even though Britannica and Macmillan continue to be anchored to the dichotomy of defence/external and security/internal, respectively, by providing the words "national security" and "internal security", is evidence of this trend. The evolving concept of security must be scrutinised, with special attention paid to the notion of human security, boosted by UN General Assembly resolution 66/290 and the NATO Strategic Concept 2022, and currently under investigation by the Exploratory Team of the NATO Science and Technology Organization. So far, the meaning of “human security” remains unclear. References 1. United Nations Development Programme (UNDP), Human Development Report 1994: New Dimensions of Human Security, New York, UN, 1994. 2. UN General Assembly (UNGA), Follow-up to paragraph 143 on human security of the 2005 World Summit Outcome, resolution adopted on 25 Oct. 2012, A/RES/66/290, in GAOR, 66th sess., Suppl. no. 49. 3. NATO Heads of State and Government, Warsaw Summit Communiqué, 9 July 2016, Press Release (2016) 100. 4. NATO Heads of State and Government, London Declaration, 4 dec. 2019, Press Release (2019) 115. 5. NATO Heads of State and Government, Brussels Summit Communiqué, 14 June 2021, Press Release (2021) 086. 6. NATO Heads of State and Government, Madrid Summit Declaration, 29 June 2022, Press Release (2022) 095. 7. NATO Strategic Concept 2022, adopted at the Madrid Summit, 28-29 June 2022. 8. NATO, Human Security: Approach and Guiding Principles, https://www.nato.int/cps/en/natohq/official_texts_208515.htm?s electedLocale=en. 9. Marsili, Marco, The Role of the Armed Forces in Homeland Security, in Book of Abstracts of the XI Portuguese Con


Mitglied im Netzwerk von Contact: CFCI / Müller-Reichert Lab Silke Tulok / Dr. Gunar Fabig Silke Tulok¹, Gunar Fabig¹, Andy Vogelsang¹, Thomas Kugel², Thomas Müller-Reichert¹ ¹TU Dresden, Faculty of Medicine Carl Gustav Carus, Core Facility Cellular Imaging, ²TU Dresden, Faculty of Medicine Carl Gustav Carus, Divisional Management, IT Department ¹TU Dresden, Faculty of Medicine Carl Gustav Carus, Core Facility Cellular Imaging Abstract The FAIR concept (Findability, Accessibility, Interoperability, Reproducibility) of data management is of relevance for all current areas of research. For imaging data obtained from both light and electron microscopy, data management is associated with a number of challenges related to the size, complexity, dimensionality, visualization and quantitative analysis of the acquired data. We have started to use the Python-based and open-source image data management software OMERO. This software package has been introduced by the Open Microscopy Environment developers of the University of Dundee. OMERO is an encouraging option to manage microscopy data. It is installed on a virtual machine and connected to a central data server to manage the storage of images in a multi-user environment. In addition to long-term data storage, it provides possibilities for saving important metadata in an efficient manner, thus avoiding multiple copies of data. It can also handle open source-based processing tools for image analysis, thereby allowing effective image analysis workflows. The Core Facility Cellular Imaging (CFCI) at the Faculty of Medicine Carl Gustav Carus (TU Dresden) is currently running a pilot project for testing the use and handling of the OMERO software. This is done together with interested users of the imaging facility and a research group. Currently, we are pushing forward this pilot study on a small scale without any data steward. Our experiences argue so far for giving data management issues into the hands of dedicated personnel not fully involved in research projects. As funding agencies will ask for higher and higher standards for implementing FAIR- data principles in the future, this will be a relevant topic for the whole research community. We want to introduce a convenient solution, which could be applicable for many users within the DRESDEN-concept research alliance and demonstrate how to establish and manage OMERO in a facility context. 2020 March TiM conference: first introduction to OMERO 2020 October Letter of support for the I3D:bio grant application 2022 February First local meeting with IT to start a pilot project (10 TB server space) 2022 March Support by RDM4mic for setting up the OMERO server 2022 May Cooperation agreement with I3D:bio for support during pilot project 2022 May IT infrastructure (storage & virtual machine & staff) ready to start 2022 July OMERO setup finished, test environment at IT department 2022 September OMERO login (only for members of the Faculty of Medicine) 2022 October Preliminary teaching materials provided by I3D:bio team 2022 November Start uploading of data (light-sheet microscopy, live-cell imaging, slide scanner) 2023 March TiM conference - First hands-on training with I3D:bio team (tagging, data structure) 2023 April OMERO open for all TU members, web access from all over the world 2023 April Start to implement analysis workflow in OMERO environment 2023 August Second hands-on meeting with I3D:bio team (scripting, key value templates) 2023 August Meeting with local IT for future expansion (IT resources, personnel resources) 2023 September Pilot implementation for medical education (parallel data access for >300 students) RDM4mic OMERO Research Data Management for Microscopy Swedlow et al. developed OME-TIFF DFG funds German BioImaging Network Funding for NFDI4BIOIMAGE by DFG Funding for I3D:bio by DFG 2000 2012 2019 2023 2022 - 2024 2023 - 2028 Information Infrastructure for BioImage Data https://www.i3dbio.de TiM Conference First hand-on meeting


2.6 P′ 2.9 1.1 0.1 0.4 2.5 2.3 13 9.4 1.4 0.7 +1.9 1.5 +1.0 0.8 -0.9 P K K′ (x 3.4) (x 3) (x 4) (x 2.4) (x 3.3) (x 4) (x 3.3) (x 4) 7.7 P′ 3.7 3.5 4.2 0.5 3.3 6.1 30.0 24.0 1.4 0.3 +1.8 4.0 +0.3 3.65 -1.5 P K K′ (x 1.3) (x 1.8) (x 1.4) (x 9.5) (x 7.7) (x 3.7) (x 2) Anatomy of energy pathways in the subtropical gyre of the North Atlantic Pauline Tedesco1, Jonathan Gula2,3, Ali Mashayek1 1University of Cambridge, Earth Sciences, United Kingdom, 2University of Western Brittany, Laboratory of Ocean Physics and Satellite remote sensing (LOPS), France; 3Institut Universitaire de France, France pfmt2@cam.ac.uk Our energy analysis uses the concept of energy separation in a time-mean ( ) and time-varying ( ) component: with the horizontal velocity components, the reference density, a 4-year average, and deviation from this average. The steady-state balance of and reservoirs is analyzed with a regional formulation of the Lorenz Energy Cycle (Lorenz, 1955): K K′ K = 1 2 ρ0(u2 + v2) and K′￼= 1 2 ρ0(u′￼2 + v′￼2) (u, v) ρ0 ( . ) ( . )′ K K′ 2. Theory P′ P K K′ Swind(K) Sb. drag(K) Ssubgrid diss(K) T(K) −C(K, P) C(K′ , P′ ) Ssubgrid diss(K′ ) Sb. drag(K′ ) Swind(K′ ) T(K′ ) −TV(K, K′ ) −TH(K, K′ ) −CV(K, K′ ) −CH(K, K′ ) CH(K′ , K) +CV(K′ , K) Energy rates of change related to: • : wind stress, bottom drag, subgrid dissipation. • : non-local effects being spatial redistribution due to pressure work and advection. • : conversion between energy reservoirs. • : local and non-local eddy-mean energy conversions. • : energy conversions related to buoyancy flux. S( . ) T( . ) C( . , . ) −C(K, K′￼); C(K′￼, K) C(K, P); C(K′￼, P′￼) Scheme of ocean energy pathways as described by the Lorenz Energy Cycle (Lorenz, 1955). Dashed arrows denote non-local effects. Terms are defined positive in the direction of the arrow. Adapted from Capo et al., (2018). 1. Context What is the leading-order energy balance of the subtropical gyre of the North Atlantic? Which flows does it rely on, and how does it vary in space? • The North Atlantic is a key region in the global ocean circulation and plays a central role in regulating our climate (Ganachaud and Wunsch, 2000). • Its response to climate change is constrained by energy transfers between basin-scale time-averaged currents and smaller-scale (hundreds to the order of a kilometer) time-varying currents, including low- frequency mesoscale and submesoscale currents and high-frequency internal waves. • Although understanding the energy pathways of North Atlantic’s subtropical gyre is crucial for accurately representing its role in climate models, we lack (1) a description of energy pathways at the basin-scale (2) based on a dataset simultaneously resolving the different time-varying flows. Snapshots of surface (right) temperature and (left) normalised relative vorticity. (Right) Streamlines show 4-year averaged surface currents. Black square denotes the subtropical gyre region. 4. (time-mean) and (time-varying) budgets for tidal scenario K K′ (Top) Vertically-integrated averaged over a 4-year period. The four sub-regions: Coastal Gulf Stream and separation, Gulf stream’s extension, Interior and Eastern boundary are shown as squared areas. Streamlines show 4-year averaged surface currents. (Left and right) Frequency-wavenumber spectra and scheme of ocean energy pathways for the four sub-regions. In the schemes, amounts have been computed from time-averaged and vertically-integrated terms and then horizontally-averaged [10-3 m3 s-2]. K + K′ K′ : main energy balances : weak energy pathways (x <.>): ratio between net contributions in tidal and non-tidal scenarios Subtropical gyre’s interior • is larger than the reservoir by a factor of 6 and is dominated by submesoscale currents and internal waves. • and budgets are insensitive to tidal forcing. • budget follows a Sverdrup-like balance: only region with a net export provided by the wind. • reservoir is mainly energised by wind and tides. K′ K K K′ K K K′ • State-of-the-art


Rotational Evolution and Radii of Young Sun-like Stars in NGC 2264 Laurin M. Gray & Katherine L. Rhode Indiana University, Bloomington, IN (USA) Background & Motivation • Understanding the origin and evolution of the Solar System and other Sun-like stars and planetary systems is a primary goal of modern astrophysics. • Studying T Tauri stars provides insight into the early interactions between Sun-like stars and their protoplanetary disks, and the time scales governing disk dissipation and planet formation. • NGC 2264 is a well-studied, nearby (~760 pc) open cluster with an age of ~3 Myr and a large T Tauri star population. The wealth of literature data make it an ideal target for developing our methods. Observations & Methods • The WIYN 3.5-m telescope and Hydra multi-object spectrograph were used to obtain high-dispersion (R ~ 21,500) spectra of stars in NGC 2264 and measure the stars’ projected rotation velocity (v sin(i)) values. • Our final NGC 2264 sample includes ~250 T Tauri stars. Roughly 30 are likely spectroscopic binaries; we excluded these stars from some analysis because they can yield overestimated v sin(i) values. • We use cross-correlation to measure v sin(i) and can measure values down to ~11 km/s. Our cross-correlation template stars have a range of temperatures matching those of our sample stars. We also observed v sin(i) standard stars to check our measurement accuracy. Future Work Open Cluster IC 5070 NGC 2264 IC 348 Upper Sco h Persei Age (Myr) 1-3 2-3 2-6 8-10 ~14 Distance (pc) 795 760 315 140 2100 References Baraffe et al. 2015, A&A, 577, A42 Jackson et al. 2018, MNRAS, 476, 3245 Somers et al. 2020, ApJ, 891:29 Acknowledgements We thank Catrina Hamilton-Drager and Luisa Rebull for sharing data and helping us design the project. We also thank the IU Astronomy Department and IU College of Arts & Sciences for providing funding. We have selected four additional clusters (see table), ranging from 1-14 Myr in age, for similar analysis. This will allow us to investigate the rotational evolution of low-mass stars during the timescale when protoplanetary disks dissipate. HR diagram of NGC 2264 stars used in the model comparison, with isochrones (yellow dashed lines) and mass tracks (black dotted lines) from the starspot-free Baraffe et al. 2015 model (left) and Somers et al. 2020 model with 51% starspot coverage (right). The main sequence is approximated at 100 Myr by the solid orange line. The measured v sin(i) values of the stars are indicated by the color bar, and open symbols mark stars with v sin(i) below our 11 km/s resolution limit. Vertical gray lines mark temperature-based subgroups used in the model comparison. At the age of NGC 2264 (~3 Myr), the model with starspots fits the data better than the starspot-free model. Spectra of a K2 cross-correlation template star (top) and three NGC 2264 stars (bottom three), with our v sin(i) values marked. The absorption lines broaden as v sin(i) increases. Stars with Accreting Disks May Rotate Slower Stars in Binary Systems May Rotate Faster Starspots Are Needed to Match Measured Radii Questions? Contact me at: grayla@iu.edu • A 2-sample K-S statistical test finds that the v sin(i) distributions do not have a statistically significant difference (p=0.126), but the large fraction of stars that lie below our resolution limit could mask a genuine difference in the two samples. • The fact that a higher proportion of CTTSs have low v sin(i) values compared to WTTSs seems to imply that stars with accreting disks may rotate more slowly than stars without active accretion. • 59% (49/83) of disked, CTTS stars have v sin(i) <11 km/s, while only 36% (47/130) of WTTS stars have v sin(i) below this limit. • Binarity can cause overly wide CCF peaks, resulting in overestimated v sin(i) values; this analysis only includes binaries with clearly resolved CCF peaks or single-lined binaries identified by differing radial velocities at different epochs. Stars identified as “single sy


What's the problem we are addressing ? Why is it important? Sub-Saharan African communities face multiple livelihood challenges, including agri-food systems that are under pressure to sustain a growing population, in the context of environmental change, including climate change, and rising fuel and food prices due to global conflict and other global market prices shocks, e.g. the Covid-19 pandemic For the more than 60% of sub-Saharan Africans who are smallholder farmers, agri-food systems are not just sources of income. They are vital for sustainable livelihoods, including food security, sanitation, and access to education and healthcare, and can drive inclusive, locally-led sustainable development within rural communities. What is our approach to solving the problem? BIO4Africa will empower smallholder farmers to generate new sources of income by creating value from locally available biomass, utilising agricultural and food processing residues in a circular, bio-based approach to economic development. Our focus is on developing simple, small-scale and robust bio-based technologies adapted to local needs and contexts, including biomass types. These will support farmers and local businesses to sustainably produce a variety of higher value bio-based products from agriculture and food processing residues (animal feed, fertiliser, pollutant absorbents, construction materials, packaging, solid fuel for cooking and catalysts for biogas production). Products developed through this project will further contribute to sustainable local community development, by addressing food production, household energy, and health needs, e.g. bio-based soil improvement, cooking fuel, and water filtration products. Circular bioeconomy approaches offer opportunities for income generation from agricultural and food processing residues, e.g. corn cobs, while also guiding fossil fuel-free pathways for sustainable community development, e.g. reducing waste directly and over the product life cycle, displacing fossil-based products such as plastics with bio-based alternatives, and developing novel products, e.g. forage-based protein extracts. Developing and strengthening circular bio-based value chains in sub-Saharan Africa can support rural communities to access ecologically and socially sustainable economic opportunities. Project Team and Key Collaborators Côte d’Ivoire: Institut National Polytechnique Félix Houphouet- Boigny (INP-HB) Denmark: Food and Bio-Cluster Denmark France: RAGT Energie SAS & Centre de coopération Internationale en Recherche Agronomique pour le Développement Ireland: Celignis Ltd. & Munster Technological University Ghana: Savannah Young Famers Network (SavaNet), 0km Nomads, Agri-Business Innovation Hub Greece: Q-Plan International Advisors PC, Draxis Environmental SA Kenya: Eastern Africa Farmers’ Federation Society Netherlands: Stichting IHE Delft Institute for Water Education, Grassa BV Senegal: Université Assane Seck De Ziguinchor (UASZ), SCPL SA, Association d’Appui aux Initiatives de Paix et de Développement, Energeco Afrique, GIE Country Farm Spain: Barcelona Plataforma Empresarial SL, Fundacion Corporacion Tecnologica de Andalucia, Sustainable Innovations Europe SL Uganda: Kabarole Research and Resource Centre (KRC), African Forum for Agricultural Advisory Services United Kingdom: African Agricultural Technology Foundation We aim to support the deployment of the bioeconomy in rural areas in four sub-Saharan African countries: Senegal, Ghana, Uganda and Côte d’Ivoire, through the development of bio-based solutions and value chains with a circular approach to drive the cascading use of local resources and diversify the income of farmers. During the four-year term of the project: small-scale bio-based technologies will be adapted to local needs and context, and piloted in the target regions, technology pilot cases will be supported by laboratory analysis and field trials of the resulting bio-based products with the target consume


Magnetic Coriolis darkening in cool stars Charly Pinçon - Institut d’Astrophysique Spatiale, OSUPS, Observatoire de Paris with the collaboration of L. Petitdemange, R. Raynaud, L. Garcia, A. Guseva, E. Alecian, and M. Rieutord 8th TESS/15th Kepler Asteroseismic Science Consortium Workshop 15-19 July 2024, Porto, Portugal Introduction Modeling the surface brightness distribution of stars is of prime importance to interpret the large amount of available interferometric, spectropolarimetric, or photometric observations. Beyond stellar physics, this is also a prerequisite to characterize exoplanets or our Galaxy. Stellar rotation is known to be a key physical ingredient in this regard. In rapidly rotating, hot massive stars with a stably stratified radiative envelope, the centrifugal flattening can make the poles hotter and brighter than the equator; this so-called gravity darkening is today well constrained (e.g., von Zeipel 1924, Bouchaud et al. 2020). In contrast, for low-mass cool stars, the picture remains uncertain as it requires one to model the MHD turbulence that develops in their convective envelopes. In this poster, we present the results by Raynaud et al. (2018) and Pinçon et al. (2024) who studied the effect of the Coriolis force on the surface luminosity distribution of thick convective envelopes, as well as the effect of potential dynamo magnetic fields. MHD simulations - MagIC and Parody codes: solve anelastic MHD Navier-Stokes equations. - Rotating convective envelopes in [ ri , ro ]. - Parametric study: about 100 simulations. - Density contrast between 20 – 400. - Entropy jump to force convection. - Stress-free and insulating boundaries. - Thick shell: representative of a 0.35 ∼ Msun dwarf or a PMS star Fig. 3: Spherical representation of the mean luminosity distribution (measured by the Nusselt number Nu) for the nonmagnetized model and the most magnetized dynamo model (i.e., the highest value of Pm) represented in Fig. 1. Radial velocity fluctuations Results Rosurf > 1 → Turbulent homogeneization of the surface. Rosurf < 1 →Complex interplay between rotation and self-sustained magnetic fields. - Rotation-constrained turbulence can generate a strong equatorial jet (Fig. 2) : Radial heat flux inhibited, dark equatorial band (Fig. 1). - With magnetic dynamo, Pm ↗ → B ↗ : Lorentz force quenches the equatorial jet (Fig. 2) and the luminosity profile flattens (Fig. 1). In conclusion, in rapidly-rotating cool stars, an equatorial darkening may occur, whose contrast depends on the rotation rate and the magnetic field intensity (see Fig. 3). Fig. 1: Surface heat flux (measured by the Nusselt number Nu) as a function of the colatitude, and for different values of the magnetic Prandtl number Pm. These profiles are mean values computed over azimuth and time. N.B: The parameters of the models are Ek=3 10-4, Pr=1, Ra~ 107, Nρ=6. Fig. 2: Same as in Fig.1 but for the mean profile of the azimuthal velocity (inside the rotating frame of rotation rate Ω). Fig. 4: Schematic transit of an exoplanet occulting a star with an equatorial jet dimmer than the rest of its photosphere. The bottom plot shows the occultation light curve (black line), the differential flux measured for the six times shown above (points), as well as the transit signal that would be observed for a uniform limb- darkened star (gray). Surface Rossby number Magnetic Prandtl number Prospects Such a magnetic Coriolis darkening can have an impact on not only the stellar luminosity estimate, but also on planet transit retrievals, in the same way as limb and gravity darkening effects. These predictions will have to be tested in the future, either in a direct way through high resolution interferometry or indirectly through misaligned transits (Fig.4).


2. Access to technology is not obvious 2. Fluorescence Fluctuation-based Super-Resolution Microscopy (FF-SRM) napari-superres an open-source implementation of methods for Fluorescence Fluctuation-based Super-Resolution Microscopy (FF-SRM) 3. Superres plugin 4. Conclusions Rocco D’Antuono1,2, Raúl Pinto Cámara3,4, Paul Hernández-Herrera4, Esley Torres García3,4, Alejandro Linares4, Haydee Hernández5, Adán Guerrero4 1 Crick Advanced Light Microscopy STP, The Francis Crick Institute, London, United Kingdom 2 Biomedical Engineering, School of Biological Sciences, University of Reading, Reading, United Kingdom 3 Centro de Investigación en Ciencias, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México 4 Laboratorio Nacional de Microscopía Avanzada, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México 5 Posgrado en ciencias e ingeniería de la computación Universidad Nacional Autónoma de México, Ciudad de México, México Acknowledgements We are grateful to Kurt Anderson (CALM head, The Francis Crick Institute) for supporting and encouraging the project and the professional development of the CALM staff. We thank Dr. Chris Wood (LNMA) for critical reading of the grant proposal. RD’A works at the Francis Crick Institute which receives its core funding from Cancer Research United Kingdom (CC0199), the United Kingdom Medical Research Council (CC0199), and the Wellcome Trust (CC0199). This project is entirely based on the use of open-source software that makes science easier, a huge thank you to the developers of: numpy, matplotlib, pandas, JupyterLab, napari, etc. The future software development will be supported by the napari Plugin Foundation award (Chan-Zuckerberg Initiative). References 1. Alva, Alma, Eduardo Brito-Alarcón, Alejandro Linares, Esley Torres-García, Haydee O. Hernández, Raúl Pinto-Cámara, Damián Martínez, et al. 2022. “Fluorescence Fluctuation-Based Super-Resolution Microscopy: Basic Concepts for an Easy Start.” Journal of Microscopy, August. https://doi.org/10.1111/jmi.13135. 2. Agarwal, Krishna, and Radek Macháň. 2016. “Multiple Signal Classification Algorithm for Super-Resolution Fluorescence Microscopy.” Nature Communications 7 (1): 13752. https://doi.org/10.1038/ncomms13752. 3. Miao, Yuting, Shimon Weiss, and Xiyu Yi. 2022. “PySOFI: An Open Source Python Package for SOFI.” Biophysical Reports 2 (2): 100052. https://doi.org/10.1016/j.bpr.2022.100052. 4. Yahiatene, Idir, Simon Hennig, Marcel Müller, and Thomas Huser. 2015. “Entropy-Based Super-Resolution Imaging (ESI): From Disorder to Fine Detail.” ACS Photonics 2 (8): 1049–56. https://doi.org/10.1021/acsphotonics.5b00307. 5. Cox, Susan, Edward Rosten, James Monypenny, Tijana Jovanovic-Talisman, Dylan T. Burnette, Jennifer Lippincott-Schwartz, Gareth E. Jones, and Rainer Heintzmann. 2012. “Bayesian Localization Microscopy Reveals Nanoscale Podosome Dynamics.” Nature Methods 9 (2): 195–200. https://doi.org/10.1038/nmeth.1812. 6. Gustafsson, Nils, Siân Culley, George Ashdown, Dylan M. Owen, Pedro Matos Pereira, and Ricardo Henriques. 2016. "Fast live-cell conventional fluorophore nanoscopy with ImageJ through super-resolution radial fluctuations." Nature communications 7 (1): 1-9. https://doi.org/10.1038/ncomms12471 7. García, Esley Torres, Raúl Pinto Cámara, Alejandro Linares, Damián Martínez, Víctor Abonza, Eduardo Brito-Alarcón, Carlos Calcines-Cruz, et al. 2021. “Nanoscopic Resolution within a Single Imaging Frame.” BioRxiv, October, 2021.10.17.464398. https://doi.org/10.1101/2021.10.17.464398. 8. https://github.com/RoccoDAnt/napari-superres 5. Future developments • Fluorescence microscopy is a well-developed imaging modality that is used in life sciences to study tissues, organoids, and cells. The inspection on the microscopic scale is limited by the resolving power of the used optical system, but more specialized techniques for Super-Resolutio


104 105 106 107 108 Modified mean [-] 104 105 106 107 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Total volume eroded [m 3 ] 100 101 102 103 Modified mean [-] 100 101 102 103 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Final max. elevation [m] 100 101 102 103 104 Modified mean [-] 100 101 102 103 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Final mean elevation [m] 10-1 100 101 102 Modified mean [-] 100 101 102 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Final stdev elevation [m] 10-1 100 101 102 Modified mean [-] 10-1 100 101 102 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Final max. slope [-] 10-3 10-2 10-1 100 Modified mean [-] 10-3 10-2 10-1 100 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Final mean slope [-] 10-2 10-1 100 101 Modified mean [-] 10-2 10-1 100 101 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Final stdev slope [-] 103 104 105 Modified mean [-] 103 104 105 106 Standard deviation [-] γ D Kbed Kblock Tr z0 τc ∆z τcb Total blocks delivered [# ] 1) CIRES and Dept. of Geological Sciences, CU Boulder 2) EarthLab, CU Boulder 0.0 0.2 0.4 0.6 0.8 1.0 x / L 0.0 0.5 1.0 1 f c 0.0 0.5 1.0 0.0 0.2 0.4 0.6 0.8 1.0 x / L 0.0 0.5 1.0 1 f c 0.0 0.5 1.0 0.0 0.2 0.4 0.6 0.8 1.0 x / L 0.0 0.2 0.4 0.6 0.8 1.0 Elevation / total baselevel lowering 0.0 0.2 0.4 0.6 0.8 1.0 x / L 0.0 0.2 0.4 0.6 0.8 1.0 Elevation / total baselevel lowering 0.0 0.2 0.4 0.6 0.8 1.0 x / L 0.0 0.2 0.4 0.6 0.8 1.0 Elevation / total baselevel lowering A B1 C1 B2 C2 Legend Constant normalized elevations of 0.2, 0.4, and 0.6 1-fc Fraction of bed exposed at 400 ky τ* Ratio of bed shear stress to total shear stress at 400 ky mean τ* = 0.63 mean 1-fc = 0.95 mean τ* = 0.45 mean 1-fc = 0.89 τ* τ* γ = 0 m-2 γ = 0.2 m-2 γ = 1.0 m-2 γ = 0.2 m-2 γ = 1.0 m-2 1 2 3 4 5 6 10-5 10-4 10-3 10-2 Baselevel lowering rate [m/yr] 1 2 3 4 5 6 10-5 10-4 10-3 10-2 Baselevel lowering rate [m/yr] γ = 5 m −2 γ = 4 m −2 γ = 3 m −2 γ = 2 m −2 γ = 1 m −2 γ = 0.5 m −2 γ = 0.2 m −2 γ = 0.1 m −2 c= 1.5 c= 1.0 c= 0.5 c= 0.25 Slope exponent n [-] 10-4 10-3 10-2 10-1 100 Steady State Mean Slope [-] y = 1401.8x1.3613, R2 = 0.99 No blocks, constant τc = 100 Pa Blocks, γ = 5 m −2 No blocks, variable τc fit No blocks, constant τc = 0 Pa 10-5 10-4 10-3 10-2 Baselevel Lowering Rate [m/yr] 10-4 10-3 10-2 10-1 100 Steady State Mean Slope [-] y = 1401.8x1.3613, R2 = 0.99 Blocks, γ = 5 m −2 No blocks, τc = 300000E + 40 Pa Blocks, γ = 2 m −2 No blocks, τc = 120000E + 30 Pa Blocks, γ = 0.5 m −2 No blocks, τc = 70000E + 5 Pa No blocks, constant τc = 0 Pa 0.0 0.2 0.4 0.6 0.8 1.0 ∆Z = 0.00001 m/yr 0.0 0.2 0.4 0.6 0.8 1.0 x / L 0.0 0.2 0.4 0.6 0.8 1.0 ∆Z = 0.001 m/yr 0.0 0.2 0.4 0.6 0.8 1.0 x / L Elevation / total baselevel lowering Block model Threshold model Block model Threshold model 0.6 0.8 1.0 1.2 1.4 Steady state φ 10-5 10-4 10-3 10-2 Baselevel lowering rate [m/yr] 0.6 0.8 1.0 1.2 1.4 Steady state φ 10-5 10-4 10-3 10-2 Baselevel lowering rate [m/yr] τc fit to γ = 0 m −2 τc fit to γ = 0.5 m −2 τc fit to γ = 2 m −2 τc fit to γ = 5 m −2 c= 1.5 c= 1.0 c= 0.5 c= 0.25 D0 dy dx qb q high fc low fc 10-4 10-3 10-2 10-1 100 y = 998.9x1.3615, R2 = 0.99 y = 1072x1.3617, R2 = 0.99 10-5 10-4 10-3 10-2 Baselevel lowering rate [m/yr] 10-4 10-3 10-2 10-1 100 y = 1401x1.3613, R2 = 0.99 10-5 10-4 10-3 10-2 Baselevel lowering rate [m/yr] y = 2543x1.3514, R2 = 0.99 γ = 5 m −2 γ = 4 m −2 γ = 3 m −2 γ = 2 m −2 γ = 1 m −2 γ = 0.5 m −2 γ = 0.2 m −2 γ = 0.1 m −2 γ = 0 m −2 c= 1.5 c= 1.0 c= 0.5 c= 0.25 Steady state mean slope [-] 1) The interaction between blocks, discharge variability, and slope adjustment sets channel response to block delivery. 2) Blocks significantly alter topographic scaling at channel slopes below the critical slope for block transport. 3) The "n" exponent values depend on block effects and proximity to the critical block transport slope. 4) The complex influence of blocks on bed cover and form drag is well-described by an erosion th


Read Between the Lines: Closing Gaps of Materials and Methods to Build Workflow from the Publication Tazro Ohta1, Osamu Ogasawara2, Yoshinobu Masatani3, Shigetoshi Yokoyama3, Kento Aida3 1. Database Center for Life Science, Chiba, Japan 2. DNA DataBank of Japan, Shizuoka, Japan, 3. National Institute of Informatics, Tokyo, Japan Background Increasing cost of translation from text to executable scripts Galaxy as an inter-laboratory workﬂow sharing platform workflow runs on any galaxy, and the galaxy runs anywhere Fig. 1. FANTOM5 (http://fantom.gsc.riken.jp/5/) data processing protocol descriptions. (a) Description of data processing in the main paper of FANTOM 5 project. (b) Online protocol published by FANTOM 5 project. Though this is helpful, it is still not enough to reproduce the exact same results. (c) A script we made with a help by members of FANTOM 5 project. There are some missing informations from materials and methods or online protocols. a b c Application: Community ‘Pitagora’ Galaxy VM Platform: ‘Overlay Cloud’ datacenters We have been trying to develop the system that we are able to share community’s workflows developed and used in the various studies which deal with NGS data, such as Exome-Seq, RNA-Seq, ChIP-Seq, or Bisulfite-Seq. We developed Virtual appliance that includes workflows and some tools to help execution of the workflows, and the Virtualbox image and Amazon Machine Image are distributed. We also maintain public server for the test use, and documents and test data are hosted on our project website. Challenges “Overlay Cloud” project led by National Institute of Informatics (Tokyo, Japan) is building large scale cloud computing infrastructure that can distribute computing tasks via their high-speed network system “sinet”. We are testing to build galaxy environment on their cloud system, which runs all the process or application as a docker container. Apache Mesos running over the nodes and datacenter is managing computing resource, and galaxy runs on it as a container, then run tools as a docker container. We have build some tool.conf and job runner for containerized tools and are still being tested and under the benchmarking. Fig. 2. Community Galaxy VM and Galaxty Community Japan. We have been organizing Japanese local community of the galaxy developers and users. The community is sharing the tools and workflows that are used in their labs. Workflows are implemented and fully documented online with the test data. Automated test of the workflow is being developed. Packed VM is distributed as a normal Virtualbox image and Amazon Machine Image via Amazon Web Service. The community is also hosting public server (listed on the page of galaxy project ‘virtual appliance’). 🐳! Mesos Master 🐳 Mesos Slave Node Node Node 🐳! Galaxy 🐳 Mesos Slave 🐳 BWA 🐳 samtools 🐳! CLI- manager 🐳! Marathon 🐳! SCS 🐳! NFS 🐳Mesos! Master 🐳 Mesos Slave Node Node Node 🐳! Galaxy 🐳 Aurora 🐳 Mesos Slave 🐳 BWA 🐳 samtools 🐳! CLI- manager 🐳! Chronos L2VPN 🐳 Docker Container • Performance Comparison and benchmarking • Connecting published workflows to the publication •Toolshed or other data repository • Standard description or annotation of workflows • Data transfer via internet • burst buffer like cloud volume? Fig. 3. Overlay cloud system and container-based galaxy and galaxy tools. (top-left) Current system which is fully containerized computing infrastructure for the galaxy. Each application runs as a container and connected by L2VPN. Data are stored in the NFS mounted on each node. (bottom-right) Current idea of ver. 2.0 system. Apache mesos and marathon container are detached from the network of the containers of galaxy and galaxy tools which are attached to the NFS via L2VPN. This enables more portability to the running system. Publishing and sharing data analysis workflow using the galaxy platform has spectacularly reduced the cost of reproducing one's research, but following the description of data analysis which had been performed


§ Expanded Illinois Natural History Survey host database with additional records from 2010-2020 from Google Scholar literature search § Compiled host database into usable data § Wrote R script to generate summary data for various measures, using t-tests to compare 2 groups and ANOVA for over two Methods § Both the IUCN and federal status rankings showed that, on average, mussels listed as endangered used significantly fewer host families than non-threatened mussels (IUCN, 1.94 and 3.25 respectively; p<.01. Federal, 2.00 and 3.21 respectively; p<.01). § Anodontini was significantly different in host family numbers compared to Quadrulini(p<.01), Pleuroblemini (p<.001), and Lampsilini (p < .001) Mussels are commonly thought of as distinct groups of host-specialists and host-generalists (Haag, 2012). However, this research supports the idea that this division is less of a dichotomy and more of a continuum (Fig. 1). The mussels that fall into the threatened categories of the conservation assessments tended to be more specialized than those that were non-threatened (Fig. 2). Some taxa also display more specialized host use than others (Fig. 3). These insights provide predictive power that can be used to help prioritize taxon-based conservation efforts. Many thanks to the Smithsonian Institution and the National Museum of Natural History, especially to Elizabeth Cottrell, Gene Hunt, and Virginia Power. Also, a thank you to Sarah Douglass and all others involved in the creation & maintenance of the Illinois Natural History Survey Freshwater Mussel Host Database. Funding provided by the NSF. Photo by Robert Aguilar, Smithsonian Environmental Research Center. Haag, W.R., 2012. North American freshwater mussels: natural history, ecology, and conservation. Cambridge University Press Results Conclusion Acknowledgements Using Freshwater Mussel Host Use to Examine Conservation-Relevant Factors David H. Nichols1,2, John Pfeiffer1 1Smithsonian National Museum of Natural History, Department of Invertebrate Zoology, 2Hendrix College Background Freshwater mussels are some of the most endangered animals in the US (Haag, 2012). Federal and state conservation efforts are complicated by a complex life history that requires parasitizing a host. While some freshwater mussel species can parasitize a broad range of host fish species, other mussels can only complete their life cycle by parasitizing a single species. Understanding more about how these factors influence their conservation status is an essential part of influencing their conservation going forward. Big Questions § Does host number impact the level of endangerment for a mussel species? § Do different taxa of mussels have different trends in host numbers? § Based on this information, where should we focus conservation efforts in the future? Fig. 1. Frequency distribution of host number by taxon Fig. 3. Plots showing the number of host families for species across different taxa Fig. 2. Distribution of host number between mussels of various conservation status


2.Energy Response Model of Detector Global Fitting result Potential of geo-neutrino measurements at JUNO and the Local 3D model Ran Han On behalf of the JUNO collaboration (Poster no.) The Local Crust Geochemical Model Poster Wall #204 The Jiangmen Underground Neutrino Observatory （JUNO） 20 kton LS detector 3%/sqrt（E）energy resolution A multiple-purpose neutrino experiment: Reactor neutrinos, Supernova neutrinos,Geo-neutrinos, Solar neutrinos, Sterile neutrinos, Atmospheric neutrinos, Exotic searches Taishan NPP Guang Zhou Daya Bay Hong Kong JUNO JUNO Location Geo-neutrinos: a new probe of Earth's interior Open questions about natural radioactivity in the Earth 1 - What is the radiogenic contribution to terrestrial heat production? 2 - How much U and Th are in the crust and particularly in the mantle? 3 – A global check of the standard geochemical model (BSE)? 4 - What is hidden in the Earth’s core? (geo-reactor, 40K, …) Geo-neutrinos: anti-neutrinos from the Earth. U Th and 40K in the Earth release heat together with anti-neutrinos in a well fixed ratio. They bring to Earth’s surface information about the chemical composition of the whole planet. Geo-neutrino Spectrum Earth’s surface heat flow JUNO Potential in Measuring Geo-neutrinos • 400events/year, much larger than existing experiments • With 10 years: total uncertainty reach 5%（2TNU) • Comparison of the global reference model (18% crust) and a benchmark accuracy of the local model(8% crust) The energy spectrum geoneutrino signal vs radiogenic heat the precision of the geo-neutrino measurement The chi2 distribution of Mantle geo JUNO JUNO Data collection (U & Th abundances),3000 points Preliminary surface model (0.5º x 0.5º) Preliminary vertical model (4 layers) The Local Crust Geophysical Model Why Local 3D model The 3D density distribution （one line） The crust thickness around JUNO. Results from the inversion of Bouguer gravity anomalies, constraint by the seismic sounding The 3D Vs structure R. Han, Y.F.Li et al.Chin.Phys.C(2016) Zhi-Wei LI (IGGWH, CAS) Ruo-Han GAO (CUGB) • Near continental margin, affected by the geology evolution of South China Block and the South China Sea • Paleogeographic evolution of South China fold belt during Permian-Jurassic time and proposed flat-slab subduction model for propagating • Local geology, including the geometry of strata, distribution rocks play important role in geo-ν flux estimation What’s the special of JUNO Geology Significant uncertainties exist in current global models. High-resolution local crust model are needed Global CRUST1.0 model has low resolution (1°× 1°) Global abundance model has no spatial resolution and large uncertainties Continuous Seismic Waveforms, from 450 Stations in South China Geophysical data source Local Neutrino Geo-Science Working Group


Iván Muñoz Rodríguez1,2, Antonis Georgakakis1, Francesco Shankar2 et al. (submitted); e-mail:ivan.rodriguez@noa.gr 1National Observatory of Athens, 2University of Southampton Diﬀerenal evoluon of AGN in clusters Comparisson with observations: We calculate the fraction of X-ray AGN in a cluster parent sample deﬁned as in observations. We compare the results of the models with the observations of Matini et al. (2009, 2013). We select galaxies and AGN in the cluster sample following selection eﬀects as deﬁned in observations. Only galaxies/AGN within the virial radius, brighter than a magnitud limit and within a velocity dispersion are consider a members. The impact of selection eﬀects is illustrated in the ﬁgure on the left. The number of AGN represent the ﬁeld expectation by model construction. Results are shown in the ﬁgure on the right. The model underpredicts the number of AGN at z~1.2 respect the observations. At z~0.75 model prediction is consistent with observations. Finally, at low redshift, z~0.2, the model seems to overproduce AGN respect cluster observations, although ﬁrm conclusions cannot be made since observations only place a lower limit. References: Aird et al. (2018); Behroozi et al. (2019); Georgakakis et al. (2017, 2019); Klypin et al. (2016); Martini et al. (2009, 2013); Peluso et al. (2022) Motivation and semi-empirical model construction: The role of diﬀerent AGN triggering mechanisms remains as one of the open questions in Astrophysics. We studied the inﬂuence of small-scale environment (<1 Mpc) into the AGN triggering mechanism. We developed a novel semi-empirical model (SEM) to construct AGN mock catalogues based on state-of-the-art observations. A graphical workﬂow of this model is shown in the ﬁgure on the left. The starting point are dark matter N-body simulations (MDP2, Klypin et al. 2016), that are populated with galaxies using abundance matching techniques (UNIVERSEMACHINE, Behroozi et al. 2019). Then AGN are painted on this galaxies constrained by the latest observations of AGN populations. The latter step is done under the explicit assumption that accretion events are independent of the environment (i.e halo mass). The ﬁgure shows a 10 Mpc/h slice of a box from MDP2 cosmological simulation with 1000 Mpc/h side size at the snapshot z=0.75. The dots represent the positions of dark matter haloes (top panel), galaxies within these dark matter haloes (middle panel) and AGN within the same dark matter haloes (bottom panel). The key feature of this approach is the reproduction by construction of the predictions and observables (e.g. HMF, SMF and XLF). The key parameter to populate galaxies with AGNs is the speciﬁc accretion rate deﬁned as λ=Lx/M★. It is related with two observables that have been well characterized in the last years thanks to multi-wavelength observations in extragalactic survey ﬁelds. This has allowed to infer its probability distribution P(λ). It describes the probability of a galaxy with mass M★ of hosting an AGN with luminosity Lx. For each galaxy in the catalog we randomly pick a λ from the distribution. This eﬀectively associate an AGN X-ray luminosity to all galaxies. AGN incidence and physical interpretation: Field expectation cannot reproduce the observations. We ﬁnd a diﬀerential evolution of the incidence of AGN in clusters respect to ﬁeld. AGN activity is enhanced at high redshift and suppressed at low redshift in massive clusters respect to ﬁeld. This point to a diﬀerent eﬃciency of AGN triggering mechanisms depending on their small-scale environment (<1 Mpc) that evolves with cosmic time. This could be explained by the diﬀerent physical processes happening in clusters respect low dense environments such as ram-pressure or galaxy interactions. This eﬀects are expected to be stronger in the outskirts of the cluster. Galaxy-Halo connection UNIVERSEMACHINE (Behroozi et al. +19) AGN-Galaxy connection Count galaxies and AGN in the cluster sample Projection of a cluster into sk


Life Cycle Phases (rows) Being part of a military command and having familiarity with the field of intelligence, the authors reviewed the U.S. Intelligence Cycle for applicability. Following the review, the authors decided to adopt this model for use within their framework. The life cycle consists of the following phases: • Planning and Direction – Establish the consumer’s intelligence requirements and plan intelligence activities accordingly. • Collection – Gather the raw data required to produce the finished product. • Processing and Exploitation – Convert the raw data into a comprehensible format that is usable for production of the finished product. • Analysis and Production – Integrate, evaluate, analyze, and prepare the processed information for inclusion in the finished product. • Dissemination – Deliver the finished product to the consumer that requested it and to others as applicable. • Evaluation – Continually acquire feedback during the Intelligence Cycle and evaluate that feedback to refine each individual step and the cycle as a whole. Project Background The Readiness Integration Center (RIC) is a Department of Defense (DoD) science gateway purpose built to provide data analysis and decision support capabilities to the Naval Aviation community with a primary emphasis on aircraft readiness and safety. The RIC ingests data from a variety of DoD authoritative sources (i.e., the systems of record charged with being the official data store), including: aircraft sensor data related to heat, vibration, built-in-test results, and fault identification; flight logs; aircraft status; maintenance records; repair manuals; supply status; and engineering data. RIC users come from several communities such as maintenance, supply, training, and engineering. These users have access to dozens of custom-built, automated and manual analysis tools as well as source data, processed data, and high-performance computing resources. Problem & Solution Recognizing that “garbage in” leads to “garbage out,” many organizations focus their efforts on pursuing a zero- defect data ingestion process. While these efforts are critical for reducing quality-related risks, the authors wanted to ensure their science gateway not only had procedures for managing quality-related risks at ingestion but also for managing such risks during subsequent analysis and reporting. By having published procedures in place before an incident, teams could better mitigate the cascade of risks that could occur if poor quality data, despite best efforts, made its way into the science gateway. For example, erroneous data could inadvertently be used during modeling and simulation activities. Then, the results of the modeling and simulation activities that were based on erroneous data could be used as evidence for a written report. That written report, based on the results of modeling and simulation activities that were based on erroneous data, could then be used as a basis for critical decisions. To ensure the science gateway had procedures for managing quality-related risks such as those in the example above, the authors developed a quality risk management framework covering 36 unique areas where quality risks could arise. This framework is intended to be used, as it was by the authors, to evaluate a science gateway’s readiness to manage quality issues arising at data ingestion and subsequent phases such as analysis and dissemination. Results In the case of the authors’ science gateway, use of the framework provided critical insights. Specifically, quality risk management procedures were written and published for only 15 of the 36 areas identified by the matrix, quality risk management procedures were written but not published for 14 of the 36 areas, and 7 of the 36 areas had no associated quality risk management procedures. Based on these findings, the authors worked with other team members to ensure the missing quality risk management procedures were written and/or publishe


Cyber Training: Pilot -- Breaking the Compute Barrier, Upskilling Agri-Food Researchers to Utilize HPC Resources Kevin Silverstein, Benjamin Lynch, Alison Joglekar NSF Award Number: 2320769 MOTIVATION The era of “Big Data in Agriculture” is rapidly moving well beyond genomics data to encompass environmental, management and socio-economic data sourced from satellites, unmanned aerial vehicles (UAV), stationary and robot-enabled ground-based sensors, and ever more data-enabled agri-food machinery (Kamilaris et al. 2017; Shekhar et al. 2017). Leveraging high-performance computing (HPC) assets into the agri-food domain space is key to realizing a big data revolution in agriculture (EU 2018; Georgiou et al. 2020). However, there is a dearth of scientists with expertise in the agri-food and natural resource domains that have compute-to-scale capabilities enabled by HPC environments. Low adoption of HPC capabilities among agri-food researchers can be largely attributed to the real (or perceived) complexity of using HPC. OBJECTIVE Onboard and upskill the agri-food workforce so they can eﬀectively and eﬃciently tap the analytical horsepower of cyberinfrastructure (CI), speciﬁcally HPC, via the creation of a tiered multi-module learning curriculum tailored to CI-applications in the agri-food sciences. CURRICULUM HPC and Cloud Concepts 05 ● Divide and conquer ● Parallelization ● Containerization ● Storage types Computer Science for the Agri-Food Researcher 04 ● Algorithm design ● Data structures ● Computational complexity (Big-O) ● Proﬁling Expanding HPC Skills 03 ● Machine Learning primer ● Data leakage ● Overtraining HPC Basics 02 ● UNIX primer ● Working remotely and scheduling jobs using SLURM ● Syncing your work with the community Computer Hardware and Resources 06 ● Processor types ● Memory ● Networking speed Future trends 07 ● GPUs continue to soar in usage ● Generative AI models are rapidly increasing in complexity 01 ● Agricultural research ● Computers in agricultural research Intro to HPC Computing for Ag Researchers COURSE MATERIAL EXAMPLES Easy-to-Learn Jupyter Notebooks Easy-to-Navigate Canvas-Based Materials CHECK OUT OUR NEXT OFFERINGS Fall 2024 – Free (U of Minnesota Aﬃliates Only) Spring 2025 – Free for Everyone Tomato Image Source: https://aeroponic.gr/en/knowledge/post/diataraches-t hrepsis-futon-trofopenies-toxikotites1.html


Visual and Chemosensory Guidance of Predatory Behavior in the California Two-Spot Octopus (Octopus bimaculoides) Dana Callahan Biology Department & Program In Neuroscience. Middlebury College. Middlebury Vermont We assessed the effects of vision and chemosensation on predatory behavior in Octopus bimaculoides.. Octopuses underwent three trials: visual stimulus only, chemical stimulus only, and visuochemical stimulus. The behavioral paradigm required octopuses to attack live prey in a clear glass tube. Predatory behaviors were quantified, and results were compared across trials. Data collection for the first 5 subjects was completed on 4/16/13, and the next 6 subjects are arriving for testing on 4/17/13. For this reason, the observations presented below are based on preliminary qualitative observations of trials. Preliminary observations suggest that the chemical stimulus alone decreased latency to attack, relative to the visual stimulus alone or the visuochemical stimulus. Preliminary observations suggest that the chemical stimulus may have increased total time spent in contact with the stimulus, suggesting that chemosensation increased perseverance in predation. Interindividual variation in basal activity level, curiosity, and prey preference may have confounded our results, as suggested by previous studies (Ambrose 1982; Byrne et al., 2001). Preliminary comparisons across trials suggest that the order in which octopuses underwent the three trials did not significantly affect predatory behavior. This suggests that learning and/or desensitization to the stimulus did not occur. Vision is primary sensory trigger for predatory behavior. Chemical stimuli are significantly less effective than visual stimuli at inducing predatory behavior., but chemical stimuli may increase predatory perseverance (e.g. frequency of attacks and time spent in contact with the stimulus). This research is still underway, and we hope to strengthen our findings as we collect data on the next group of animals. Further development of this study warrants examination of the effects of a variety of chemical stimuli on predatory behavior. Octopuses (Phylum Mollusca, Class Cephalopoda) are proven models for the neurobiology of behavior (Messenger, 1998). However, neurobiologists have not achieved a complete understanding of sensory processing in the octopus (D’Aniello et al., 2005; D’Este et al., 2008). While recent studies have demonstrated visual guidance of behavior (Byrne et al., 2001; Fiorito et al., 2005) and chemosensory abilities in cephalopods(Lee, 1992; Darmaillacq et al., 2004; Fry, 2011), the biological relevance of these sensory capabilities continues to be examined. Octopuses are active predators, preying on fish, crustaceans (e.g. shrimps, crabs), and mollusks (Ambrose, 1982; Byrne et al., 2001). Octopus predatory behavior varies among individuals and depends on prey type (Dickel et al., 2001; Cartron et al., 2013). Such complex predatory behavior requires highly effective sensorimotor integration. Octopuses use vision to guide their initial approach to prey (Young, 1965). In addition, findings that octopuses demonstrate positive chemotaxis to chemical stimuli related to prey (Lee, 1992; Fry, 2011) suggest that predatory behavior may also be influenced by chemosensation. The present study seeks to clarify the ecological relevance of octopus chemosensation by studying how vision and chemosensation interact to guide predatory behavior in the California two-spot octopus (Octopus bimaculoides). We presented octopuses with visual stimuli, chemical stimuli, or visuochemical stimuli and quantified the resulting predatory behaviors. Based on previous research, we hypothesized that vision would be the primary initiator of predatory behavior, but that the effects of vision and chemosensation on predatory behavior would be additive. In other words, we hypothesized that predatory behavior would be stimulated most strongly by visual and chemical cues


En los últimos años, España, y Asturias, se han convertido en un país receptor neto de inmigrantes. Esta migración no suele afectar en muchos casos en mejoras del nivel de salud de los. Inmigrantes. En este estudio pretendemos a partir de los datos de la Encuesta de Salud de Asturias, 2008 (ESA-08) conocer el grado de salud de la población inmigrante en Asturias. Los datos provienen de la ESA-08 (n=2500) en Asturias. Se analizan las variables de salud incluidas en la encuesta en relación al origen de la persona y se comparan con las obtenidas en la población autóctona. CCasi todas las variables de resultados de salud son mejores en inmigrantes que en población autóctona si bien muchas de esas diferencias se deben a su mayor juventud. Algunos de estos resultados son concordantes con los datos disponibles en la literatura. ANTECEDENTES Y OBJETIVO La salud en personas inmigrantes en el Principado de Asturias, 2008 Mario Margolles (1), Ignacio Donate (1), P. Margolles (2) (1) Consejería de Sanidad. Gobierno del Principado de Asturias, (2) Facultad de Medicina y Ciencias de la salud. Universidad de Oviedo MÉTODO RESULTADOS N. 640 Inmigración y salud CONCLUSIONES Declaración de conflicto de intereses: No existe ningún conflicto de intereses Situación de salud de la población inmigrante: (Encuesta de Salud. Asturias, 2008) Grupo de referencia: personas nacidas fuera de España vs personas autóctonas. Total: 2.500. Personas inmigrantes: 158. Entre paréntesis IC 95%. Autovaloración de estado de salud: Buen o muy buena OR: 1,92 (1,4-2,7); regular o mala, OR: 0,32 (0,2-0,6) incluso controlando por edad. Autovaloración estado de felicidad: NS. En cambio, SI hay diferencias en jóvenes (16-29 años): poco o nada felices, OR: 9,3 (3,4-25,6) Calidad de Vida Relacionada con la salud: diferencias significativas en las 5 dimensiones de EUROQOL-5D. Controlando por edad, las diferencias se mantienen entre los 30-64 años de edad: mejor CVRS en inmigrantes y las diferencias se ahondan con la edad (gráfico 1) Valoración de vida sexual: muy o bastante satisfactoria, OR: 1,6 (1,1-2,3). Peor valoración en mujeres inmigrantes vs hombres inmigrantes OR: 2,9 (1,3-6,6) No tener personas con las que se puede hablar (confidente): OR: 2,3 (1,1-4,9). Peor valoración en hombres inmigrantes vs mujeres inmigrantes OR: 3,1 (1,1-9,3) Morbilidad crónica: menor frecuencia OR: 0,54 (0,4-0,7). NS tras controlar por edad salvo en grupo de 45-64 años OR: 0,4 (0,2-0,8) En todas las patologías hay menor frecuencia significativa en población inmigrante que desparece controlando la edad, salvo: Ansiedad: OR: 3,2 (1,1-10,4) En el análisis por sexo aparece que las mujeres inmigrantes tienen más riesgo que las autóctonas de ansiedad OR: 46,0 (15-139) Accidentalidad: diferencias NS Autovaloración de vida social: diferencias NS Ayuda para el cuidado de menores o dependientes: OR: 1,1 (NS) Sueño: duermen menos las personas inmigrantes (en especial los hombres) pero descansan mejor: OR: 1,5 (1,1-2,3). Satisfacción con el trabajo: visión dual: buena o muy buena valoraciòn más frecuente en inmigrantes (en especial en mujeres), OR: 2,3 (1,6-3,5). Pérdida de empleo, bastante más preocupados por perder su trabajo en inmigrantes en especial las mujeres. Accesibilidad al sistema sanitario: diferencias considerables con la población autóctona. Mejor valoración de la geográfica OR: 1,5 (1,1-2,2). Muy mala percepción en la horaria OR: 1,7 (1,1-2,5), en especial en hombres inmigrantes. Necesidad de atención médica NO cubierta: mayor frecuencia OR: 2,7 (1,1-6,9), debido sobre todo a la imposibilidad de ir al médico por no poder dejar el trabajo. Frecuentación servicios sanitarios: Usan más los servicios de MF OR: 1,8 (1,1-2,4) y ginecologia OR: 1,8 (1,1-2,9). Usan menos los de enfermería. Casi la totalidad de la atención sanitaria ha sido financiada públicamente. En cuanto a la hospitalización es NS si bien si hay diferencias en motivo de ingreso: la población inmigrante ingresa menos en cirugía


Investigating Galaxy Quenching with the SDSS: Stellar Metallicities as a Tracer of Quenching Mechanisms J. Trussler1,2,*, R. Maiolino1,2, D. Goddard3, C. Maraston3, D. Thomas3, Y. Peng4 1Cavendish Laboratory, University of Cambridge, 2Kavli Institute for Cosmology, University of Cambridge 3University of Portsmouth, 4Peking University *jaat2@cam.ac.uk Local galaxies can be split up into two main classes: gas-rich star-forming galaxies and gas-poor passive galaxies. However, it is still unclear which mechanisms are primarily responsible for quenching star formation in galaxies. Peng et al. [1] analysed stellar metallicities of 26,000 SDSS galaxies and found that galaxies with stellar masses below 1011 M are primarily quenched due to the halting of the supply of cold gas (strangulation). We take this analysis further by making use of the much larger spectroscopic sample in SDSS DR7, analysing the stellar metallicities of 70,000 local galaxies. We study the systematic difference in stellar metallicity between star-forming and passive galaxies (see Fig. 1) to put constraints on the possible quenching mechanisms and timescales. We analyse the light-weighted stellar metallicities of 70,000 SDSS galaxies, obtained using the spectral fitting code FIREFLY [2]. The bimodality in the star formation rate – stellar mass plane is used to divide galaxies into star-forming, green valley and passive. We compare the observed metallicity differences between star-forming and passive galaxies with the predictions of simple closed-box models, to determine whether local galaxies quench primarily through strangulation. Galaxy group catalogues [3] are used to further split the galaxy population into centrals and satellites to investigate the dependence of galaxy quenching on environment. The observed average stellar metallicity difference between star-forming and quenched galaxies is well matched by the predictions of a closed-box model for galaxy evolution (Fig. 2), indicating that local galaxies quench primarily through strangulation. We find that the typical quenching timescale is 2 Gyr and is roughly independent of stellar mass. The sample is further divided into central and satellite galaxies and again we determine the average stellar metallicity difference between star-forming and passive galaxies. We find that the metallicity differences are similar for both central and satellite galaxies, except at intermediate stellar masses, where the stellar metallicity enhancement of centrals is slightly larger (~0.1 dex) than that of satellites. Figure 1. The stellar mass-stellar metallicity relation for star-forming galaxies (blue curve), green valley galaxies (green curve) and passive galaxies (red curve) with 0.02 < z < 0.085. Galaxies are binned in 0.1 dex stellar mass bins and the median stellar metallicity in each bin is plotted. Error bars correspond to the 1σ error on the mean value. Figure 2. The observed average stellar metallicity difference between star-forming and passive galaxies is shown by the black curve. Error bars represent the 1σ error on the metallicity difference. The coloured lines show the stellar metallicity difference predicted by a simple closed-box model at different times after strangulation. We find that the typical quenching timescale is 2 Gyr. Figure 3. The blue curve shows the average stellar metallicity difference between star-forming central and passive central galaxies. The red curve shows the average stellar metallicity difference between star- forming satellite and passive satellite galaxies. We also investigate the dependence of the strangulation signal on the local overdensity (overdensity data taken from [4]). Fig. 4 shows that the metallicity difference for central galaxies depends very weakly on the local overdensity, even over an overdensity range of 2 dex. Satellite galaxies also show a weak dependence on overdensity, except in the smallest overdensity bin, where an excess metallicity difference is observed at


FORK-TO-FARM AGENT-BASED SIMULATION TOOL AUGMENTING BIODIVERSITY IN THE AGRI-FOOD VALUE CHAIN This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101000499 The BIOVALUE tool is a dynamic, and modular agent-based simulation tool of the agri-food value chain with the aim to analyse experimentally the introduction of marginal traditional varieties starting with novel food dish recipes and processed food products and closing the value chain with an extensive breeding program throughout Europe. The proposed tool will be applied to real-world decision-making to extract and augment the value of so far underutilised and genetically diverse crops in Europe. Furthermore, environmental impacts of future water availability and climate change scenarios will be incorporated modularly into the BIOVALUE tool. The main aim of the BIOVALUE project is to develop a dynamic and customisable tool that will analyse the link among biodiversity, the agri-food value chain, the environment and consumer’s preferences and health. To this end, a demand driven approach (fork-to-farm) is adopted. The ultimate outcome of the research are novel food dish recipes and processed food products from the underutilised, genetically diverse crops resulting from the extensive breeding programme foreseen within the project. BioValue is divided into 11 Work Packages, 3 devoted to the ethical aspects (WP1), the dissemination & exploitation activities (WP10) and the management (WP11), and 8 core research Work Packages (WP2-9), ensuring that scientific excellence is accomplished throughout the project (Figure 2). www.biovalue-project.eu info@biovalue-project.eu # B I O V A L U E © COPYRIGHT AXIA Innovation Figure 2: BioValue’s Research related WPs Figure 1: BioValue’s Concept