Abstract The GAPDH locus is attractive for recombinant protein expression according to knockdown and transcriptomic data as it is the 3rd most expressed gene in HEK293. DHFR KO cells growing exclusively in media supplemented in hypoxanthine and thymidine (HT). Integration of exogenous DHFR alongside the gene of interest in DHFR KO cells effectively rescues cells allowing selection simply using media without HT supplementation. CRISPR-Cas9 is an efficient gene-editing technology that allows scientists to effectively remove, insert and modify DNA in cells Introduction This proposed methodology aims to optimize recombinant protein production in HEK293 cells to improve their efficacy, lower the potential of immunogenicity and increase the industrial potential of human derived cell hosts. Significance Methods Results Conclusions Fig. 1 Bienzymatic (EcoRV & BbsI) Digestion of cloned PX330 CRISPR plasmids confirms successful guide integration Successful integration results in one band whereas unsuccessful integration results in 2 bands. For each guide, 2 clones were tested via this method and sequenced. At least one clone for each guide was successfully integrated (C, control (undigested) & D, digested) Fig. 2 PCR Screening Confirms homozygous DHFR1 Knockout Genomic DNA from single cell clones was isolated and a PCR reaction was run using primers designed outside of the determined target sites to test for a reduction in the produced fragment. All clones except clone 20 exhibit successful DHFR1 homozygous knockout. Fig. 3 Fluorescent Microscopy Confirms Stable integration of eGFP and Puromycin in HEK293 cells HEK293 WT cells were transfected with the Cas9-AAVS1 construct and the HDR-AAVS1. Cells underwent selection for 10 days using 1.5ug/ml of puromycin followed by single cell cloning to confirm stable integration of the HDR template into the AAVS1 site All CRISPR-Cas9 constructs were successfully cloned into the PX330 plasmid as confirmed by digestion using EcoRV and BbsI restriction enzymes and sequencing PCR screening shows successful isolation of monoclonal populations with desired homozygous DHFR1 knockout as evidenced by the reduction in the product size eGFP-Puro-AAVS1 cell line was successfully created as cells were selectable using puromycin and maintained eGFP expression for over 18 days post transfection Generate DHFR2 KO cells using successful DHFR1 KO clones followed by partial integration of DHFR and finally eGFP and the remaining portion of DHFR to create the complete experimental cell line. eGFP expression to be compared to that of the eGFP-Puro-AAVS1 Control Cell line using Western Blot and Flow Cytometry Confirm site specific integration of eGFP and puromycin genes in the eGFP-Puro-AAVS1 cell line by screening single cell clones using PCR and sequencing Adapt this system to produce a therapeutic recombinant protein (e.g. EPO) by cloning in the gene into the position of eGFP in the HDR-GAPDH2 plasmid Future Directions Acknowledgments I would like to thank Dr. Ihab Younis, Dr. Ravichandra Bachu and Dr. Mazen Sidani for their mentorship throughout this project. I would also like to thank Dr. Simon Faulkner and Dr. Mohamed Bouaouina for their useful insight. Finally, I would like to thank Maya Kamaldean, Bernadette Bernales and Maria Navarro for their support in the lab. References Establishing a Stable Recombinant Protein Production Cell Line Using CRISPR- Cas9 Mediated Genome Editing of HEK293 Cells Martin Sikhondze | Dr. Ravichandra Bachu | Dr. Ihab Younis | Dr. Mazen Sidani Biological Sciences Program | Carnegie Mellon University Qatar Recombinant proteins are biopharmaceuticals used in the treatment of various diseases including cancer and diabetes. Current methods to produce these therapeutics are dependent on bacterial & CHO cells however these cell hosts have non-identical post transcriptional and translation modifications increasing the likelihood of ineffective protein products in addition to possible immunoge


European Conference on Crop Diversification September 18-21 September 2019, Budapest, Hungary Evaluation of the Land Equivalent Ratio index in barley-pea and bread wheat-faba bean intercropping Tavoletti S*±1. F. Straccia1, A. Merletti1, L. Iommarini1 1 Dipartimento di Scienza Agrarie, Alimentari ed Ambientali, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona – Italy ∗ Speaker ± Corresponding author: s.tavoletti@univpm.it 1 Introduction To improve agricultural sustainability, a valuable strategy could be the increase of biodiversity of cultivated fields through intercropping (Bedoussac et al., 2015; Brooker et al., 2015; Yu et al., 2016). Cereal-legume intercropping exploits the complementarity between these two groups of crops. In 2017, a field trial showed that the Mix1(50-50) was not effective because barley was too much competitive against pea, and faba bean plant density could have been increased. In the present research, new barley-pea and bread wheat-faba bean combinations were evaluated to increase the Land Equivalent Ratio (LER) and to reduce weed competition in mixed vs sole legume crops. 2 Materials and Methods 2.1 Trial 1- WP2 Barley-Pea trial: conventional farming – no herbicide treatments. At the UNIVPM Experimental Station a split-plot design (4 replicates, sub-plot size 9x1.2m2) was performed including one barley (Tea) and two pea (Hardy, Astronaute) varieties as sole crops and mixed crops: Mix1(50-50), Mix2(33-67), Mix3(25-75), Mix4(20-80). Nitrogen fertilization (whole-plots) was applied as shown in Table 1, amount of N in mixed crops being proportional to the barley seed density. The trial was sown on February 1st, 2018, and harvested on July 3rd, 2018. Table 1. Trial 1: Nitrogen fertilization plan (N kg/ha). Pea sole Barley sole Mix1 (50:50) Mix2 (33-67) Mix3 (25-75) Mix4 (20-80) High N 20.0 80.0 40.0 26.4 20.0 16.8 Low N 0.0 40.0 20.0 13.2 10.0 8.4 2.2 Trials 2 and 3 –WP4 Barley-Pea trials: organic farming – no nitrogen fertilization. Two trials were performed with participatory farmers at 2 locations: Monte San Martino – MC (Trial 2) and Sterpeti - PU (Trial 3). At each site, a randomized complete block (4 replicates) was applied (Plot size: 50x4.5m2 for Trial 1 and 50x4.2m2 for Trial 2. One barley (Tea) and one pea (Hardy) varieties were included as sole crops and as Mix2(33-67) and Mix3(25-75). Trials were sown on Jannuary 26th, 2018 (Trial2) and March 28th, 2018 (Trial3), and harvested on July 3rd, 2018 (Trial2) and July 9th, 2018 (Trial3). 2.3 Trial 4 – WP4 bread wheat-faba bean trial: organic farming. The trial was performed at Rocca Priora – AN as a randomized complete block design (3 replicates, plot size 10x1.2m2). Three bread wheat (ACA320, Bologna, Marcopolo) and two faba bean (Chiaro di Torre Lama, Prothabat69) varieties were evaluated as sole crops and as Mix1(50-50), Mix2(50-65), Mix3(50-80), Mix4(33-75) and Mix5(33-80). The trial was sown on January 31st, 2018 and harvested on July 19th, 2018. 3 Results 3.1 Trial 1: Barley-Pea In mixed crops, LERbarley was always much higher and LERpea was always much lower than expected (Table 2). Even though LERtotal was always higher than 1, Mix1 showed the highest values because of the high yielding ability of barley in mixed crop combinations. As frequently observed in mixed cropping trials, the LERtotal values were higher at low than at high nitrogen fertilization levels.


Estudio sobre la tecnología y cómo te ves a vos mismo En este estudio, nos interesaba en cómo el uso de las redes sociales y la tecnología podía influir en cómo te ves. Teníamos una entrevista con preguntas sobre qué tecnología y redes sociales usas, y encontramos unas respuestas muy interesantes. ¡Gracias por charlar con nosotros durante nuestro tiempo en Namqom! La tecnología …de la gente dice que usa estos aparatos. • 49% de la gente usa un celular una o más veces al día. • La televisión es muy popular. Programas de television como Elif y Lazos de Sangre y películas como Rapido y Furioso se ven con frecuencia. 69% de la gente de Namqom mira a la televisión una o más veces al día. • Sin embargo, muchas personas hablaban de la adicción a los celulares, especialmente los jóvenes. • La adicción a los teléfonos celulares es un gran problema mundial, que se asociaba con disturbios de sueño, depresión y ansiedad. Las redes sociales • Mucha gente en Namqom disfruta las redes sociales, especialmente Facebook y WhatsApp. De hecho, 80% de la gente usa las redes sociales. • La razón principal para usar las redes sociales es para comunicarse con familia y amigos. • Sin embargo, es importante que tengamos cuidado con el uso excesivo de estas aplicaciones. Las aplicaciones como Facebook se crean para fomentar un uso repetitivo. …de la gente dice que usa estas aplicaciones. Ideales de cuerpo y cómo te ves La exposición repetida a imágenes de ciertos tipos de cuerpos en las redes sociales puede no solo cambiar lo que ves, sino también cómo te ves a vos mismo. Te preguntamos cómo te ves a vos mismo, qué cuerpo es el más saludable y cuál es el más atractivo para ver si tu uso de las redes sociales cambió de alguna manera tu preferencia por el tipo de cuerpo. • La mayoría de los hombres dicen que el cuerpo N°6 es cómo se ven y que el cuerpo N°4 es el más sano o saludable. • En 2009, los hombres dijeron que el cuerpo N°5 fue el más sano o saludable. Había un cambio cultural. • La mayoría de las mujeres dice que el cuerpo N°5 es cómo se ven y que el cuerpo N°4 es el más sano o saludable. • En 2009, las mujeres dijeron que el cuerpo N°6 fue el más sano o saludable. Había un cambio cultural. La conexión: Las redes sociales y cómo te ves • 52% de la gente ha tratado de adelgazar en su vida. • 12% de la gente ha tratado de engordar en su vida. • 27% de la gente no se siente bien con su cuerpo. • A la mayoría (55%) de las mujeres le gustaría adelgazar. • A la mayoría (38%) de los hombres le gustaría adelgazar. • Sin embargo, 71% de la gente dice que les gustan sus cuerpos. • Los sitios de redes sociales se introdujeron en el mundo muy recientemente. • El uso de ellos y la tecnología puede influir cómo te ves y cómo te sientes con tu cuerpo. • Por eso, ten cuidado con las redes sociales. ¡Pueden afectarte más de lo que piensas! • La religión también influye mucho cómo la gente se ve. Algunas personas dicen que le gustan sus cuerpos porque Dios se los dio. Datos internacionales Medir tu peso y altura nos ayudó mucho en calcular tu índice de masa corporal (IMC). El IMC nos indica el estado nutricional: si está por debajo del peso apropiado, en el peso normal, con sobrepeso o con obesidad. Cuando eligieron una silueta–una que se parece a vos o una que le parece la más saludable– se observó que prefirieron siluetas que corresponden a diferentes estados nutricional. 97% 89% 17% 80% La tecnología Las redes sociales Ideales de cuerpo y cómo te ves La conexión: Las redes sociales y cómo te ves Porque medimos tu peso y altura 70% 68% 58% 52%


Towards HPC-Friendly Quantum Programming Models Mateusz Meller Supervisors: Dr. Oliver Thomson Brown1, Dr. Joseph Lee1, Vendel Szeremi2 1. EPCC, University of Edinburgh 2. Hartree Centre, STFC, UKRI Introduction Even though quantum computing promises advantage on some of the applications, such as quantum hamiltonian simulation, current devices are prone to errors and have short coherence times. Most research focuses on circuit-oriented programming model. While this model provides universal computation, it is inefﬁcient. On the other hand, analog quantum computers, can solve some of the problems by leveraging native hardware controls, providing shorter time-to-solution, thus enabling us to study larger problems. However, this is an under-explored territory, especially from the point of view of HPC. No satisfactory tools exist for the integration of classical HPC with analog QC. The goal of this project is to develop such tools. Figure 1. There are two general schemes for implementing Quantum Simulation on a quantum computer. In a circuit-oriented scheme we apply sequence of unitaries, known as gates. In Hamiltonian-oriented scheme we synthesise Hamiltonian terms which evolve in time. Figures taken from [1]. Analog Quantum Simulation On-machine instructions Programming Model Figure 2. Gate-based quantum circuit code written using CUDA Quantum [2]. User speciﬁes the quantum kernel as a sequence of gates applied to the quantum register. Figure 3. Hamiltonian-oriented code written using SimuQ - framework for programming quantum simulation on analog devices [1]. Figure 6. Resulting pulse schedule generated by the circuit-based Qiskit compiler [3]. Figure taken from [1]. Figure 7. Resulting pulse schedule generated by SimuQ compiler targeting analog machines. Figure taken from [1]. Figure 8. General outline of the project. Having stated the problem, the project will consist of 4 phases: Setup, Prototyping, Development and Validation. Project goals Problem: Design HPC friendly programming model for analog quantum computing Port Quake MLIR Dialect to XDSL Develop dialect for analog QC in XDSL Explore mappings between dialects and underlying constructs Understand target ISA by collaborating with Strathclyde Develop hardware-aware QIR lowering, with optimal instruction selection Validate solutions on QC simulator (Tensor Networks / Statevector) Identify higher-level abstractions mapping well to Dialects Benchmark on a real quantum device Setup Prototyping Validation Develop DSL which leverages ﬁndings Development Results Compilation process C++ Clang AST to LLVM MLIR Quake Dialect QIR (quantum extended LLVM IR) Device code registration Link-time override (CUDAQ func to MLIR func) Link Opt Exe Figure 4. Compilation process for the CUDA Quantum framework. CUDAQ kernel constructs are mapped to Quake MLIR dialect, which is further lowered to Quantum Intermediete Representation (QIR). Figure 5. Compilation process for the SimuQ Quantum Analog framework. The steps involved focus on the correct resource and instruction scheduling. py Instruction Schedule Conﬂict Resolver Hamiltonian Synthesizer Block Schedule Scheduler Signal Line Schedule Pulse Translator Pulse Schedule Exe References [1] Peng, Yuxiang, Jacob Young, Pengyu Liu, and Xiaodi Wu. ‘SimuQ: A Framework for Programming Quantum Hamiltonian Simulation with Analog Compilation’. Proceedings of the ACM on Programming Languages 8, no. POPL (5 January 2024): 2425–55. [2] Kim, Jin-Sung, Alex McCaskey, Bettina Heim, Manish Modani, Sam Stanwyck, and Timothy Costa. ‘CUDA Quantum: The Platform for Integrated Quantum- Classical Computing’. In 2023 60th ACM/IEEE Design Automation Conference (DAC), 1–4, 2023. [3] Aleksandrowicz, Gadi, Thomas Alexander, Panagiotis Barkoutsos, Luciano Bello, Yael Ben-Haim, David Bucher, Francisco Jose Cabrera-Hernández, et al. ‘Qiskit: An Open-Source Framework for Quantum Computing’. Zenodo, 23 January 2019. Quantum Circuit


FREEZE! A manifesto for safeguarding and preserving born-digital heritage Aims. Finding ways to preserve born-digital heritage has become a matter of urgency and growing concern. Websites, games and interactive documentaries each bring specific challenges that need to be addressed. It takes three to tango: Ensuring that our digital lives and digital creativity are not lost to future generations requires a joint effort by the principal players: creators, heritage professionals and policy makers. This manifesto lays out the actions they need to take today to safeguard born-digital heritage. Creators. Digital products are at risk of being lost from the moment they are created. Creators are therefore part of the preservation process - whether by writing code, editing digital content or by creating some other form of digital expression. We encourage creators as follows: • Invest time to describe your work carefully, whatever platform you use to store and manage your work. Provide at least a minimal set of metadata (who, what, where, when). Always include versioning data and information about the rights status of the work. • Document your work as copiously as possible. Documentation enables future users to understand and reuse your work more easily. Describe the technical specifications of your work, for example the hardware and software used to create the work. • If possible, assign open licenses (such as Creative Commons) to your work. This enables content to be reused. Reuse will help to ensure the longevity of your work. • Where possible, use open-source software and open-source hardware. Your work will withstand the test of time better, since open means: independent of proprietary technology and vendor lock-in, and transparent availability of the source code and building blocks of your work. Heritage Professionals. Digital material presents several challenges for heritage professionals. For instance, the sheer amount of material created, dispersed among diverse platforms, hardware and domains makes selection a daunting task. There is little standardization of file formats and environments that supports these. Norms for describing and managing this complexity are inadequately developed. The tasks involved in collecting, preserving and making digital materials accessible fall into three categories. We encourage heritage professionals as follows: Policy • Identify vulnerable digital heritage in your area of activity and find out which forms of digital heritage your organisation develops, manages or intends to manage (in line with collection policy plans). Create a convergent digital landscape by harmonising collection policies with other institutions. To ensure success, avoid overlaps and gaps in the combined collections. • Develop policies for acquiring and keeping born-digital material accessible sustainably. Use existing models, as described in the ‘DIY Handbook of Web Archaeology’. • Obtain legal advice regarding storage and reuse. Act responsibly when using, managing and making personal data or information accessible. Implementation: • Where possible, cooperate with (fellow) institutions and industrial partners to find collective solutions. Choose robust –preferably open - technical infrastructures and operating systems. • Assume that your current technology will need to be updated regularly. So prepare your exit strategy: can you move data from system A to system B easily? • Use well-documented, open standards, e.g. for storage formats and exchange protocols. Non- dependence on suppliers ensures your archive material remains interchangeable in the future. • Agree clear guidelines for delivery of acquired and transferred born-digital material: when, why and under what terms. Outline the rights and obligations before and after material is transferred. If accessibility is an objective, organise this when the acquisition is realised: lay down terms for accessing the collections. • Ensure copious metadata records are kept of digi


A cross-institutional, FAIR VIVO for Metabolomics Michael Conlon, Kevin S. Hanson, Taeber Rapczak, Naomi Braun, Christopher P. Barnes, University of Florida, Gainesville, Florida, USA Metabolomics Data The Metabolomics Workbench (MWB) (https://metabolomicsworkbench.org) is the National Metabolomics Data Repository of the US National Institutes of Health (NIH). Anyone can deposit data to the MWB. As of August 28, 2019, the workbench provides data from 982 publicly available studies. Another 205 studies are currently embargoed and will be available subject to their embargo dates. MWB develops and uses RefMet (http://bit.ly/2PkxY5p), a nomenclature for representing metabolites found using mass spectroscopy (MS) and nuclear magnetic resonance (NMR) techniques. Investigators upload study data to the workbench and provide metadata regarding themselves and their work. The MWB provides an API that can be used to access metadata about studies and investigators. MWB metadata has been mapped to an ontology developed by the authors to represent it as RDF and load it to VIVO. PubMed (http://pubmed.gov) is an open access index to literature in metabolomics. Its API can be used to find and retrieve publication data regarding metabolomics investigators. Many groups use PubMed data in VIVO. PubMed data has been mapped to the VIVO Ontology (http://vivoweb.org/ontology/core) Data regarding software used in metabolomics studies has been difficult to find. An index to such software will be created and curated by a group at the University of Colorado Anschutz Medical Campus funded by the NIH. This data will be in the form of a spreadsheet. The authors will use the Software Ontology (SWO) (http://www.obofoundry.org/ontology/swo.html) to represent the data as RDF and load the data into VIVO. Metabolomics Metabolomics is the scientific study of metabolites present within an organism, cell, or tissue. Human metabolites are small molecules found in human tissue that occur naturally as a result of human metabolism, or are present as a result of drugs, food components, or exposure to environmental conditions. Along with genomics (the study of DNA), transcriptomics (RNA), proteomics (proteins), metabolomics provides information regarding biochemical compounds and processes in cells, leading to a better understanding of cellular biology. “Metabolic profiling can give an instantaneous snapshot of the physiology of a cell, and thus, metabolomics provides a direct "functional readout of the physiological state" of an organism.” (Wikipedia http://bit.ly/2Pg06X3) Such profiles can be used to distinguish tissue types, disease states, and health status of individuals. Understanding the changes in profiles over time can lead to improved understanding of diseases such as cancer and diabetes, leading to potential treatments. Over 450,000 human metabolites have been identified to date. Metabolomics is considered an emerging field. Technical challenges in compound identification and data analysis are significant. The NIH Common Fund Metabolomics consortium originated in 2013 to help address these and other challenges. Fourteen investigators across the US are supported to advance metabolomics. Five are engaged in compound identification, seven in software tools and data analysis. The group at UCSD supports the Metabolomics Workbench, a data repository. The group at the University of Florida provides overall coordination for the consortium. FAIR Data Principles The FAIR Data Principles (Wilkinson, et. al https://www.nature.com/articles/sdata201618) provide a framework for creating data that can be used by groups beyond the group that created the data. The principles are difficult to achieve in practice and much has been written about implementation. VIVO supports the principles naturally, it is designed to share data. • Findable – data should be found using search engines on the Internet • Accessible – the data can be accessed without technical, legal or operational barr


Humulus scandens Hamei japonez Familia Cannabaceae, Clasa Magnoliopsida Plantă anuală, volubilă, cățărătoare. Frunzele sunt palmate, opuse, de 5-13 cm lungime, cu 5-9 lobi, cu marginea dințată. Florile sunt verzi palid – gălbui, cu cinci petale. Florile bărbăteşti și femeieşti apar pe plante separate (plante dioice). SPECII CU ASPECT SIMILAR Humulus lupulus Fructul este o achenă ovoidală, galben-maronie. Semințele mici sunt răspândite de vânt și apă . Foto credit: https://www.discoverlife.org/20/q?search=Humulus+japonicus Floare cu fruct semințe 5-13 cm Floare Parthenocissus quinquefolia Floare Frunze mai mari, cu 3-5 lobi; Fructele seamănă cu un con. Frunze compuse din 5-7 foliole mai mici, zimțate, care toamna capătă o culoare roșie intensă; fructele sunt sub formă de bobițe (bacă), violet închis. CUM ÎL RECUNOAȘTEM? Specie de interes pentru UE


INTRODUCTION Our research is focused on the study of FIR images (1.5°, 100px) of the region around WD GD 61 located at R.A. (J2000) 04h 38m 39.37s and Dec. (J2000) 41o 09’ 32.34” using Improved Reprocessing of the IRAS (IRIS) and AKARI surveys from SkyView Virtual Observatory along with SIMBAD Astronomical Database and Gaia Archive of ESA. a) b) Figure 1: Isolated Dust Structure Contour Around WD GD 61 a) in IRIS 100 μm (major axis = 1.093o, minor axis = 33.62’) and b) in AKARI 90 μm Pre-processed Using Aladin v10.0 (Tag 0 Represents the Pixel with Minimum Relative Flux Density). METHOD AND TECHNICAL DETAILS From various white dwarf candidate catalogues, clearly isolated dust structures around the white dwarfs are selected in IRIS and AKARI surveys using SkyView Virtual Observatory followed by cross-validation using Simbad Astronomical Database. Then .fits extension files of the selected region are downloaded to pre-process in Aladin v10.0. After contouring of isolated structure, major and minor axes are determined to calculated inclination angle (Holmber, 1946). The pixel extraction is done for accessing relative flux density values of each pixels. The data is then processed to calculate the dust properties such as flux distribution, dust color map and temperature distribution (Schnee et al., 2005) subsequently visualized using python. For the distance calculation, parallax data is accessed from the Gaia Archive of ESA. The calculated distance is then used to estimated the mass of the structure (Young et al., 1993). a) b) Figure 2: Dust Color Map of IRIS Relative Flux Density Distribution at a) 60 μm and b) 100 μm a) b) Figure 3: Dust Color Map of AKARI Relative Flux Density Distribution at a) 90 μm and b) 140 μm RESULTS The size of the cavity within the region is 23.18 pc × 11.97 pc with an inclination angle of 61.53°. With the IRIS data, the temperature of the whole region was found between a maximum value 24.39 ± 0.61 K to a minimum value 22.53 ± 0.31 K with an offset of 1.86 K and an average temperature of 23.16 ± 18.55×10−3 K. Similarly, using AKARI data, the temperature was found between a maximum of 14.48 ± 0.37 K and a minimum of 13.38 ± 0.18 K with an offset of 1.12 K and an average temperature of 13.75 ± 1.10×10-3 K. Distribution of the temperature in both the surveys was found to be Gaussian. a) b) Figure 5: Gaussian Fit of the Temperature Distribution in a) IRIS and b) AKARI data STUDY OF DUST PROPERTIES AROUND THE WHITE DWARF GD 61 IN IRIS AND AKARI MAPS Sanjay Rijal1, Madhu Sudan Paudel2 1,2Tri-Chandra Multiple Campus, Institute of Science and Technology, Tribhuvan University, Nepal sanjay1.745401@trc.tu.edu.np1, mspaudel27@gmail.com2 ANALYSIS The inclination angle of the cavity indicates that it is neither a face-on (i→0o) nor an edge-on (i→90o) object. Very low offset temperatures (< 5K) suggest that the cavity might be evolving independently with less disruption from background radiation sources. Also, the Gaussian distribution of the temperature in both the surveys implies that the region might be in a local thermodynamic equilibrium. REFERENCES Holmberg, E. (1946). Investigations of the systematic errors in the apparent diameters of the nebulae. 117. Schnee, S. L., Ridge, N. A., Goodman, A. A., & Li, J. G. (2005). A complete look at the use of iras emission maps to estimate extinction and dust temperature. The Astrophysical Journal, 634 (1), 442. Young, K., Phillips, T., & Knapp, G. (1993). Circumstellar shells resolved in iras survey data. ii-analysis. The Astrophysical Journal, 409, 725–738.


Data enrichment & indexation Link to Simbad, VizieR, data producer,... Positional indexation Photometry Data description Catalogs/tables/columns description Abstract Aknowledgments, copyrights... fits fits fits images Tabular data SQL-like script Tabular data ReadMe Awk script METAdata Origin ; author, date... Keywords : mission, wavelength, astronomical words Acronym or usual name Media contents : images, spectrum, cube meta-data (tex) FTP Spectrum output An intuitive web application using « widgets » result of a SQL-like query script. It includes capabilities as zoom, scaling,... The SED output The VizieR web application A big data collection ●~14,000 catalogs coming from the most popular astronomical journals : A&A, ApJ, AJ, MNRAS,.. ●Large surveys catalogs : ESA, NASA,.. ➔2MASS (~450,000,000 records) ➔SDSS (~800,000,000 records) ➔GAIA simulation catalog (2,000,000,000 records) ➔... ●~400 catalogs containing spectra ●~1150 catalogs containing time-serie (CoRoT ~300,000 timeseries) ●~130 catalogs containing images A close collaboration between documentalists, astronomers and computer scientists The VizieR ingestion pipeline is operated by documentalists and astronomers for the catalogs coming from journals. The big catalogs coming from large surveys are ingested by computer scientists and astronomers. Added value The documentalists add relevant information like URL links to external applications, links to the Simbad database or to object from other VizieR catalogs. The documentalists add visualization output for associated data like the spectrum or incorporate images in the VizieR result page (ex CoRoT, Herschel). Catalog management at CDS ~ project support ~ VizieR provides access to the most complete library of published astronomical catalogs (data tables and associated data) available on line and organized in a self-documented database (12359 catalogs in may 2014). The VizieR search engine uses indexation based on several criteria which requires the expertise of scientists and documentalists to ingest each catalog. These meta-data go with an efficient position search engine adapted to big data. G. Landais, T. Boch, M. Brouty, S. Guehenneux, F. Genova, F. Ochsenbein, P. Ocvirk, E. Perret, FX. Pineau, AC. Simon, P. Vannier, S. Lesteven Observatoire Astronomique de Strasbourg, Université de Strasbourg/CNRS, UMR 7550 Catalog entry Catalog archived A data storage adapted to big surveys VizieR is involved in data dissemination coming from missions. The VizieR positional indexation is adapted to big volumetry : VizieR provides currently data coming from mission like 2MASS, SDSS, WISE which produces big volumetry. This efficient data access including crossmatching capabilities with other VizieR catalogs or with SIMBAD put the CDS as a partner of major projects like GAIA . VO dissemination The VOTable is a standard output available in VizieR and is recognized by VO-softwares like the Aladin image viewer (CDS) or the spreadsheet TOPcat (University of Bristol). The VOTable output is a XML format includind standardized definitions (UCD) which are included in the VizieR meta-data. The VizieR data and VizieR search capabilities (like to search by position in all VizieR) are fully accessible throught the VO. VizieR collaborations with space missions : VizieR is present in different steps of a mission : ●Collaboration with the Gaia project providing simulation GAIA catalog with all CDS capabilities. ●Collaboration with CoRoT to publish a catalog containing >300,000 time-series of exoplanets ●Provide a set of catalogs used by the XMM pipeline Take advantage of meta-data to compute photometry plots among ~2400 catalogs ~1000 filters This widget integrates three linked views: a zoomable plot with photometry points, a sky chart and the VizieR tabular data. The VizieR web application contains facillity like the all-sky viewer « Aladin Lite », links to external applications or easy tools (SAMP) to put data in a VO-application


Developing Metrics for Assessing the Impact of Open Science Services Huajin Wang, Melanie Gainey, Patrick Campbell, Katie Behrman, Sarah Young University Libraries, Carnegie Mellon University, Pittsburgh, PA, USA Summary Preliminary results Methods Logic Model Metrics framework development Program overview Future assessment development Research Data Management DMP Tool Open Science Symposium AIDR Collaborative Bioinformatics Hackathon dataCoLab protocols.io Open Science Framework KiltHub R Python OpenRefine Citizen Science LabArchives APC Fund Open Educational Resources ●Usage and attendance data were collected from vendors and dashboards for the following tools and platforms: KiltHub (Institutional Repository), Open Science Framework, LabArchives, protocols.io, OSDC Newsletter, open science-themed workshops, Carpentries workshops, Open Science Symposium, and AIDR. ●The KiltHub dashboard includes departmental affiliation for all staff, faculty, and graduate students at CMU. We used that dataset to determine the departmental affiliation for users and attendees of all other platforms and events. Since undergraduates are not included in the KiltHub dashboard, we did not include their departmental affiliation and they are represented in our data as “undergraduates”. ●Data collected between January and April 2021 for each platform or event was used to generate summary data on departmental and institutional affiliation of users. ●Platform usage over time data for KiltHub, LabArchives, and protocols.io were collected in December 2021. University Libraries’ Open Science and Data Collaborations (OSDC) Program at Carnegie Mellon University (CMU) was created in 2018 to meet the growing needs and interest from researchers in making data and other research products publicly available and reproducible. The program offers five categories of support from librarians and staff with expertise in research and data sharing: tools, trainings, events, assessment, and collaboration. Our services provide end-to-end support throughout the research lifecycle. After three years of building the program, we are currently assessing the success of our initiatives with the development of a logic model and usage metrics. Development of metrics will allow us to take the scattered usage or attendance data from each platform and event and integrate them into a single dataset. We can then answer questions about who is using our services, how they are using them, and what impact the services are having on research workflows. Preliminary data suggest that users come from a broad swath of disciplines with researchers from Heinz College of Information Systems and Public Policy being the heaviest users of program services. The department with the highest number of public items on KiltHub was the Software Engineering Institute, but these deposits represented many users that each have a low number of uploads. Superusers (users with a high number of public items) came from other departments such as Psychology, Computer Science, and Materials Science Engineering. Platform usage for KiltHub, LabArchives, and protocols.io has increased each year since 2019 when we licensed protocols.io and LabArchives. Metrics data and feedback from the Advisory Group will be used to design targeted surveys. Advisory group from top users (2021) User data Targeted surveys & interviews ●How much time / money are we saving researchers ●How many grant awards / publications / career opportunities are we helping researchers to obtain ●How many communities are we helping to adopt open science ●How much are we contributing to the cultural shift ●Who uses our tools and participates our activities? ●Who are our top users? ●Which disciplines are the most engaged? ●How do people use our tools or activities? ●Why do people use our tools or activities? ●What impact are we making? Integrated user data Scattered data from each service Questions 5 Ws and 1 H Metric Variable(s) Source of Data Who User affilia


© 2022 California Institute of Technology. Government sponsorship acknowledged. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not constitute or imply its endorsements by the United States Government or the Jet Propulsion Laboratory, California Institute of Technology. National Aeronautics and Space Administration Jet Propulsion Laboratory California Institute of Technology Pasadena, California Federated Digital Twins for Flood Prediction and Analysis NASA AIST IDEAS: Thomas Huang1, Cedric David1, Gary Doran1, Jason Kang1, Grace Llewellyn1, Kevin Marlis1, Miles Milosevich (intern)1, Stepheny Perez1, Wai (William) Phyo1, Joe T. Roberts1, Catalina M. Oaida Taglialatela1 | Sujay V. Kumar2, Nishan Biswas2 | Paul Stackhouse3, David Borges3, Madison P. Broddle3, Bradley MacPhserson3 SCO FloodDAM DT: Raquel Rodriguez Suquet4, Simon Baillarin4, Frederic Bretar4,5, Gwendoline Blanchet4, Peter Kettig4 | Sophie Ricci6, Andrea Piacentini6, Thanh-Huy Nguyen6 | Guillaume Valladeau7, Jean-Christophe Poisson7 | Alice Froidevaux8, Antoine Guiot8, Romane Raynal8, Huynh Thanh-long8, Christophe Fatras9, Sylvain Brunato9, Eric Guzzonato9 [1] NASA Jet Propulsion Laboratory, Caltech Institute of Technology; [2] NASA Goddard Space Flight Center; [3] NASA Langley Research Center; [4] Centre National d’Etudes Spatiales; [5] Space Climate Observatory; [6] CECI, CERFACS/UMR5318-CNRS; [7] Vortex.IO; [8] QuantCube; [9] Collecte Localization Satellites Abstract Water resource science is multidisciplinary in nature, and it not only assesses the impact from our changing climate using measurements and modeling, but it also offers science-guided, data-driven decision support. An Earth System Digital Twin (ESDT) is a dynamic, interactive, digital replica of the state and temporal evolution of Earth systems. It integrates multiple models along with observational data, and connects them with analysis, AI, and visualization tools. Together, these enable users to explore the current state of the Earth system, predict future conditions, and run hypothetical scenarios to understand how the system would evolve under various assumptions. NASA’s Advanced Information Systems Technology (AIST) Integrated Digital Earth Analysis System (IDEAS) project partners together with the France’s Science for Climate Observatory (SCO) FloodDAM Digital Twin effort is to establish an extensible architectural solution to develop digital twins of our physical environment for Earth Science. The joint effort delivers a formal system architecture with mechanisms for the outputs of one model to feed into others; for driving models with observation data; and for harmonizing observation data and model outputs for analysis. The work presents a multi-agency joint effort to deﬁne and develop digital twin for Earth system that includes continuous integration and harmonization of the latest measurements, assimilates model simulations, AI-driven scenario-based actionable predictions, and dynamic integration of the most recent, relevant observations, here with an initial focus on water resources and ﬂood analysis case studies for proof of concept. Automate Access to Many Repositories and Services Acquire Observation and Analysis Decision Support and Science Planning Forecast and Prediction Assimilation and Numerical Models AI-based Analysis Harmonize Observation and Model Data Access and Analysis FloodDAM FloodDAM NASA Advanced Information Systems Technology IDEAS: Integrated Digital Earth Analysis System got ideas? Data-Driven Community-Driven Professional Open-Source Analysis-Driven New Observing Strategies Analytic Collaborative Frameworks Latest Observations Numerical Models Actionable Predictions Federated Architecture Multi-Agency Multi-Center Multi-Computing On-demand Product Generation Clearance: CL#23-3441 Mississippi River 2019-03 - 2019-08 Garonne River 2022–01-01 - 2022-01-31 Observations & Analysis Apache


A User-centric Approach to Trust Management in Wi-Fi Networks Carlos Ballester (University of Geneva), Jean-Marc Seigneur (University of Geneva), Paolo di Francesco (Level7), Valentin Moreno (FON), Rute Soﬁa (SITILabs, University Lusófona), Waldir Moreira (SITILabs, University Lusófona), Alessandro Bogliolo (University of Urbino), Nuno Martins (Caixa Mágica Software) Abstract—This technological demonstration goes over a new trust management framework which can assist in achieving secure connections in wireless networks, without necessarily implying the use of strong security associations. The demonstration is based on open-source software, and has been developed to run on OpenWRT as well as on Android. I. INTRODUCTION The EU ULOOP project [1] is investigating and imple- menting technology to overcome the limitation of today’s broadband access technologies, expanding the backbone in- frastructure by means of low-cost wireless technologies that embody a multi-operator model, i.e., a local-loop based upon what a speciﬁc community of individuals (end-users) is willing to share, backed up by speciﬁc cooperation incentives and “good behaviour” rules. This represents a paradigm shift in the Internet evolution, as the user may be in control of parts of the network, in a way that is acknowledged (or not) by Internet stakeholders. In such scenarios where several strangers are expected to interact for the sake of robust data transmission, trust is of vital importance as it establishes a way for the nodes involved in the system to communicate with each other in a safe manner, to share services and information, and above all, to form communities that assist in sustaining robust connectivity models. This technological demonstration goes over the trust man- agement framework provided in ULOOP, which has been currently developed to run both in open-source Access Points (OpenWRT) and in Android. The demo shall assist in ex- plaining how ULOOP envisions trust management to achieve security in a ﬂexible way, without necessarily implying the use of strong security associations. II. TRUST MANAGEMENT IN ULOOP In ULOOP, trust management and cooperation incentives are related to the understanding of how to deﬁne and build circles of trust on-the-ﬂy. Such circles of trust aim of sustain- ing an environment for allowing devices to share resources to support the dynamic behavior of user-centric networks. Trust management is based on reputation mechanisms able to identify end-user misbehavior and to address social aspects, e.g., the different levels of trust users may have in different communities (e.g., family, afﬁliation). In situations where the created network of trust is not enough to allow resources to be shared, ULOOP devices are able to use a cooperation incentive scheme that allows a node to gain credits in an amount directly proportional to the amount of shared resources: such credits can then be used to gain access to other resources. Hence, trust management and cooperation incentives aspects are split into three main blocks: i) Trust management; ii) Cooperation Incentives; iii) Identity management. From a ULOOP software suite perspective and as has been explained [2], there are modules which are activated if a ULOOP element plays the role of a regular node, or of a gateway. A ULOOP gateway is a role (software functionality) that reﬂects an operational behavior making a ULOOP node capable of acting as a mediator between ULOOP systems and non-ULOOP systems – the outside world. This gateway role may or may not be owned and controlled by a ULOOP user, it may also be controlled by an access operator. The key differentiating factor of the role of gateway, in contrast to a regular ULOOP node, is the operational intelligence and mediation capability. Similarly to ULOOP nodes, the ULOOP gateway functionality may reside in the user-equipment, in Access Points, or even in the access network. Hence, they exhibit a feature that is key in user-centric envi


ENTRE O POLÍTICO E O FAMILIAR: DISCURSOS DE ÓDIO E ATRAVESSAMENTOS CONJUNTURAIS Victória Rosa da Silva. Universidade Federal Fluminense. Niterói - Rio de Janeiro. Waldenilson Teixeira Ramos. Fundação de Empreendimentos Científicos e Tecnológicos (FINATEC). Niterói - Rio de Janeiro. Objetivo: Este trabalho se apresenta enquanto um relato de pesquisa que se endereça a refletir sobre a atual conjuntura política no Brasil e as dinâmicas de adoecimento que podem ser provocadas por esta no meio familiar. Metodologia: Parte-se de uma Psicologia Social Crítica, instrumentalizada através das contribuições de pensamentos dos intelectuais: Michel Foucault (2021), Gilles Deleuze e Félix Guattari (2011). Com o auxílio paralelo de notícias brasileiras que informam sobre os acontecimentos de violência no contexto familiar e suas repercussões no âmbito da saúde mental, principalmente nos períodos eleitorais do país. Resultados e Discussão: Em 9 de julho de 2022, Marcelo Arruda foi morto em meio a comemoração familiar de seu aniversário devido a dissonâncias políticas. Ocorreu uma troca de tiros em que, no fim, o assassino de Marcelo foi chutado pelos familiares presentes enquanto estava baleado no chão. A cena choca não só pelas violências presentes, mas pelas profundas feridas psíquicas nos membros familiares que acompanharam o desenrolar do acontecimento. Tal cenário ajuda a ilustrar certa alegoria da realidade vivida por algumas familia brasileiras, o que desvela um quadro sintomático em tempos de polarização extrema do cenário político do país, em que uma discordância entre partidos políticos têm a potencialidade de instigar comportamentos agressivos, violências sem precedentes e adoecimento mental. Não obstante, se evidencia na atual conjuntura brasileira a insurgência da propagação do discurso de ódio, que se apresenta como potencializador desse adoecimento intrafamiliar. Referências: DELEUZE, Gilles & GUATTARI, Félix. Mil platôs: capitalismo e esquizofrenia, 2. ed. Rio de Janeiro: Editora 34, 2011. FOUCAULT, Michel. Microfísica do Poder. 13. ed. São Paulo: Editora Paz e Terra; 2021. INFOGRÁFICO: ENTENDA ORDEM DOS ACONTECIMENTOS NO DIA DO ASSASSINATO DE PETISTA EM FESTA DE ANIVERSÁRIO, SEGUNDO A POLÍCIA. Site G1 - Oeste e Sudoeste. Disponível em: <https://g1.globo.com/pr/oeste-sudoeste/noticia/2022/07/16/infografico-entenda-ordem-dos-acontecimentos-no-dia-d o-assassinato-de-petista-em-festa-de-aniversario-segundo-a-policia.ghtml> . Último acesso em 24 de maio de 2023. MENDES, Sandy. PETISTA É ASSASSINADO POR BOLSONARISTA EM FESTA DE ANIVERSÁRIO NA QUAL HOMENAGEAVA LULA. Site do OUL: Congresso em Foco. Disponível em: <https://congressoemfoco.uol.com.br/area/pais/homem-e-morto-por-bolsonarista-em-aniversario-com-tematica-do- pt/>. Último acesso em 24 de maio de 2023.


Structural and Effective Pathways to the Amygdala involved in Spatial Frequency and Emotion Processing Jessica McFadyen1,6, Martial Mermillod2,3, Veronika Halász1,4, Jason B. Mattingley4,5,6, & Marta Garrido1,4,6 1 Centre for Advanced Imaging, University of Queensland, St Lucia, QLD, Australia | 2 University Grenoble Alpes, Grenoble, France | 3 Institut Universitaire de France, Paris, France 4 Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia | 5 School of Psychology, University of Queensland, St Lucia, QLD, Australia 6 Australian Research Centre of Excellence for Integrative Brain Function, Australia Method Participants N = 26, 50% female, 18-32 years (M = 22.69) Design Duration = 200ms, ISI = 750-1500ms, Viewing angle = 22.8° Technique = Magnetoencephalography (MEG) Task = Report the gender of the face Spatiotemporal Results References 1 Garvert, M. M., Friston, K. J., Dolan, R. J., & Garrido, M. I. (2014). Subcortical amygdala pathways enable rapid face processing. NeuroImage, 102, 309-316. 2 Tamietto, M., & De Gelder, B. (2010). Neural bases of the non-conscious perception of emotional signals. Nature Reviews Neuroscience, 11(10), 697-709. 3 Pessoa, L., & Adolphs, R. (2010). Emotion processing and the amygdala: from a ‘low road’ to ‘many roads’ of evaluating biological significance. Nature Reviews Neuroscience, 11(11), 773-783. Lateral Geniculate Nucleus (LGN) Pulvinar (PUL) Primary Visual Cortex (V1) Amygdala (AMY) Subcortical Medial Cortical [ 3780 ] 0 15 5 Latency Advantage for Low SF (ms) 10 fT/mm -4 -3 -2 -1 0 1 2 3 0 100 200 300 400 500 600 Lag = 13ms Time (ms) BSF LSF HSF Fearful Neutral Research Question Is there a functional subcortical route to the amygdala that bypasses the visual cortex and, if so, what spatial frequency and emotional content does it carry? Cortical Hypothesis3: Transmission of visual information to the amygdala is via the cortex: • Just as fast • Used for all information • Any pulvinar influence is due to cortical input Background Dual Hypothesis2: There is a colliculo-pulvinar pathway to the amygdala: • Fast • Direct • Used for low spatial frequencies and emotional information Conclusions Using statistical parametric mapping (SPM) and dynamic causal modelling (DCM) we found: 1. A dual model explained the data better than other plausible anatomical models1. 2. Simulated amygdala activity was influenced by the subcortical route as early as 70ms. 3. Low spatial frequency modulated neural activity earlier than high spatial frequency. 4. The subcortical route was not modulated by spatial frequency, while the cortical route conveyed primarily high spatial frequencies. p < .05 FWE -0.8 -0.4 0 0.4 0.8 0 100 200 300 400 500 600 Lag = 12ms Time (ms) Latency Cross-Correlation Analysis 10 20 30Left Right 0 10 20Posterior Anterior 30 600 450 300 150 0 Time (ms) Difference in Field Intensity (fT/mm) -1.6 0.8 0 1.6 -0.8 Low High 10 20 30Left Right 0 10 20Posterior Anterior 30 0 300 200 100 0 400 Neutral vs. Fearful Emotional Expressions Field Intensity (fT/mm) -0.4 0.2 0 0.4 -0.2 Fearful Neutral 470ms 310ms 175ms 150ms 370ms Statistical Parametric Mapping Low vs. High Spatial Frequency Dynamic Causal Modelling Anatomical Models V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT Cortical Dual Medial All = included in some models = included in all models 0 5 10 15 20 Exceedance Probability (%) Models 1 36 18 9 27 V1 AMY LGN PUL INPUT Model 21 V1 AMY LGN PUL INPUT Model 29 Cortical Dual All Medial 0 10 20 30 40 50 60 70 80 90 100 Exceedance Probability (%) 1 14 28 Models V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT V1 AMY LGN PUL INPUT = modulation by either: 1. Spatial Frequency (Low vs. High) 2. Emotional Expression (Neutral vs. Fearful) 3. Spatial Frequency & Emotional Expression V1 AMY LGN PUL INPUT


Convection in M-type dwarfs: predictions from 3D hydrodynamical model atmospheres J. Klevas1, A. Kučinskas1, H.-G. Ludwig2 1 Astronomical Observatory of Vilnius University, Saulėtekio al. 3, Vilnius 10257, Lithuania (email: jonas.klevas@tfai.vu.lt) 2 Zentrum für Astronomie der Universität Heidelberg, Landessternwarte, Königstuhl 12, 69117 Heidelberg, Germany Although convection plays an important both in the atmospheres and interiors of M-type dwarfs, its impact on the atmospheric structures and observable properties of these stars is still relatively poorly understood. In particular, standard 1D model atmospheres that are used in the analysis of M-type dwarfs rely on the calibration of convection by using mixing length parameter, MLT. As a rule, 1D model atmospheres of M- type dwarfs are computed using a fixed MLT value while in reality it may vary considerably in stellar parameter space (Magic 2015, Sonoi 2019). With the aid of 3D hydrodynamical model atmospheres, we investigate how the mixing length parameter, MLT, changes with effective temperature, gravity and metallicity typical to those observed in Galactic M-type dwarfs. We also provide a grid of MLT values that could be used with the 1D classical model atmospheres. To study convective properties of M-type dwarfs we used a new grid of 3D hydrodynamic model atmospheres (Klevas et al., in prep.) computed with CO5BOLD code (Freytag et al. 2012). The models were calculated using opacities that were grouped into 14 opacity bins based on continuum formation depth. All model had the same resolution of 140x140x160 which roughly corresponded to 1000 x 1000 x 400 km, and covered atmospheric layers in the range of -6 < log Ross <4. To investigate how convection works in M-type dwarfs, for comparison we used 1D hydrostatic models computed with LHD code using the same equation of state and opacities as the 3D hydrodynamical CO5BOLD models. This allows direct differential comparison with CO5BOLD models, thus leaving 1D hydrostatic nature and parametrization of convection as the only source of differences from the 3D hydrodynamic model atmospheres. The LHD model atmospheres were computed using the mixing length theory (Mihalas 1978), for a set of different values of MLT . Fig. 1. The mixing length parameter, MLT, obtained as the best fit of 1D model atmosphere entropy profile to that of the corresponding mean 3D model. Models in each column have identical Teff and log g values but differ in their metallicities ([M/H]) and best-fitted MLT. Grey dots are M-dwarfs observed by Kepler and TESS space missions. We present new results aimed at calibrating MLT parameter for use with the 1D hydrostatic model atmospheres of M-type dwarfs. In the range of atmospheric parameters typical to M- type dwarfs, the obtained MLT estimates vary in the range of MLT = 1.6 to 2.2 depending on the model effective temperature, gravity and metallicity, with [M/H] having the largest impact on MLT. The effect of Teff and log g are smaller and lead to changes of D MLT <0.3 and < 0.2 over the intervals of DTeff =1000K and Dlog g = 0.5, respectively. While the 1D MLT models may be used to represent optically thick layers in M-type dwarfs reasonably well, there significant deviations in the entropy profiles predicted by the 1D MLT and averaged 3D hydrodynamical model atmospheres in the outer atmospheric layers. This happens because the overshooting of convective flow into layers beyond the optical surface and subsequent adiabatic cooling are not accounted for in the 1D models. These differences can not be neglected, especially in more metal-poor stars where cooling of these layers is more efficient (Fig. 3). Extra caution is advised when layers outside of overshooting zone are of interest (log Ross < -2) because of this cooling. As shown in Fig. 1, MLT does vary significantly along the atmospheric parameter space. In particular, it is very sensitive to metallicity where the difference in MLT in model


Isophote Shapes of Early-Type Galaxies in Massive Clusters at z ~ 1 and 0 ● Dependance of a4 parameter on mass and size Kazuma Mitsuda(1), Mamoru Doi(1), Tomoki Morokuma(1), Nao Suzuki(1), Naoki Yasuda(1), Saul Perlmutter(2), Greg Aldering(2), Josh Meyers(3) GALAXY EVOLUTION ACROSS TIME, Paris, June 12-16, 2017 ① Introduction ● Size evolution of the ETG samples ● Measuring a4 parameter Refereces ● Evolution of FR fraction: fFR [写真] Dynamics of early-type galaxies (ETGs), whether they are supported by rotation or dispersion, is a clue to understand their assembly history. We compare the isophote shape parameter a4 between z ∼ 1 and 0 as a proxy for dynamics to investigate the epoch at which the dynamical properties are established. We create cluster ETG samples with stellar masses of log(M✽/M⦿) ≥ 10.5 with spectroscopic redshifts. We have 130 ETGs from the Hubble Space Telescope Cluster Supernova Survey for z ∼ 1 and 355 ETGs from the Sloan Digital Sky Survey for z ∼ 0. We ﬁnd similar dependence of the a4 parameter on the mass at z ∼ 1 and 0; the main population changes from disky (a4 > 0) to boxy (a4 ≤ 0) at a critical mass of log(M✽/M⦿) ~ 11.5 with the massive end dominated by boxy ETGs. The disky ETG fraction is consistent between these redshifts. Although uncertainties are large, the results suggest that the isophote shapes and probably dynamical properties of cluster ETGs are already in place at z > 1 and do not signiﬁcantly evolve in z < 1, despite signiﬁcant size evolution. The constant disky fraction imply that the processes responsible for the size evolution is not enough violent to convert the dynamical properties of ETGs. Slow rotators (SRs) Massive: log(M✽/M⦿) > 11.3-5 Tend to be boxy: a4 < 0 Fast rotators (FRs) Less massive: log(M✽/M⦿) < 11.3-5) Tend to be disky: a4 > 0 Dispersion Rotation Slow Rotators Fast Rotators Late-type galaxy Sab Scd Boxy E (a4<0) Disky E (a4>0) S0 (a4>0) Early-type galaxy (ETG) Spin parameter λ SRs FRs Stellar Mass MJAM [M⦿] Eﬀective radius Re[kpc] ● Dynamics and shapes of early-type galaxies (ETGs) ●Illustris Simulation (Penoyre+17) ⇒ Increase of fFR from z ~ 1 to 0 FRs at z~1 SRs at z~0 major mergers etc… z=0 z=1 We investigate evolution of disky (a4 > 0) fraction as a proxy for fFR. ➦ z = 1: HST Cluster Supernova Survey ● z ~ 1 and 0 Cluster ETG Samples z = 0: Sloan Digital Sky Survey z ~ 1 : HST z850 image, z ~ 0 : SDSS g image ② Fit ellipses with Fourier deviation ① Determine isophote contours ③ Get mean a4 value from radial proﬁle Luminosity weighted mean within 2 rPSF < r < 2 rh z=1.2 disky 2 rpsf 2 rh radial proﬁle of a4 z=1.2 boxy 2 rpsf 2 rh radial proﬁle of a4 (Right figures: example of z = 1.2 galaxies) Radial profiles of a4 parameter etc… are derived. 100x a4/a FR SR Disky Boxy log (V / σ) ● Disky ETG fraction (fdisky) at z ~ 0 and 1 Massive end (log(M✽/M⦿)≳11.5) is dominated by boxy ETGs both for z ~ 0 and 1. Disky Boxy For less massive ETGs, smaller galaxies tend to be more disky with larger a4 value both for z ~ 0 and 1. ⬇Averaged a4 value color coded on the size-mass plane ▹ ▹ z ~ 0 sample has galaxies with large sizes (σ ~ 50 - 100 km/s). → recently (z < 1) quenched galaxies? ▹ Disky fraction is consistent between z ~ 0 and 1 within uncertainty taking account of Eddington bias (no significant evolution in z < 1). ▹ z = 0 simulation: fFR z=1 simulation: fFR : z ~ 1 cluster ETGs corrected for Eddington bias Boxy shapes of massive ETGs are already in place at z > 1. ▹ Isophote shapes (boxy/disky) may not reﬂect dynamical states (SR/FR), taking account of the discrepancy between fdisky in observation and fFR in simulation at z = 0. ✻ ⬇Size-mass relation and normalized size distribution of boxy/disky ETGs ✻ normalized size log(re, M11/kpc) = log(re/kpc) - 0.57 ∙ {log(M✽/M⦿)-11} Signiﬁcant size evolution from z ~ 0 to 1 (both in boxy and disky) ⇒ ▹ Cappellari+13 Kormendy & Bender 96 Emsellem+11 K. Mitsuda et al., 2017, ApJ, 834, 109; E. Emsellem et al., 2011, MNRAS, 414, 888; M


In Europe, salmonellosis remains the second most common foodborne disease1, while hepatitis E virus (HEV) prevalence in humans has increased significantly during recent decades.2 Studies proved that pigs are common hosts of Salmonella and HEV. Hence, pork products classify as a risk factor for these zoonotic diseases. Costs of selected biosecurity measures (11) along the PPC BSM-specific calculations Country-specific values used if available Costs evaluated per sow, slaughter pig or farm conditioned by the BSM Published data, national guidelines, experts Salmonella Hepatitis E Pork production chain Consumer Biosecurity measures BSM-effect considered in QMRA QMRA OUTPUT Output translated to monetary benefits BENEFITS COSTS Economic analysis Cost-benefit analysis conducted for each of the pathogens Disease Output = change in the number of human cases due to selected biosecurity measures along the PPC Pork production chain associated incidences To assess the cost-effectiveness of the considered biosecurity measures Introduction 1 Concept and methods applied 2 Development of an economic model to assess the cost-effectiveness of biosecurity measures to reduce the burden of Salmonella and hepatitis E virus in the pork production chain Bester C.1, Marschik T. 1, Schmoll F. 2, Käsbohrer A. 1,3 1Unit of Veterinary Public Health and Epidemiology, University of Veterinary Medicine Vienna 2 Division for Animal Health, Austrian Agency for Health and Food Safety (AGES) Moedling, Austria 3 Unit Epidemiology, Zoonoses and Antimicrobial Resistance, German Federal Institute for Risk Assessment, Berlin, Germany ►Specific effective BSMs collated within BIOPIGEE will be evaluated in the pathogen-specific quantitative microbial risk assessment models (QMRA), parameterized for selected countries. The output, namely reduced human cases and prevalence in pigs, will be translated into monetary terms. In a cost-benefit analysis, the disease-specific associated costs and costs of BSMs will be evaluated against the monetary benefits of the reduced incidences and prevalence. The calculations are based on country-specific data on disease rates, cost of disease, and cost for the implementation of specific BSMs, as well as information on national pig farming structure and pork production statistics. Cost of illness Pathogen-specific methodology applied Salmonella3* Hepatitis E4,5 Country Cost per human case, 2019 Average across pathogen-specific severity outcomes AT € 980.4 € 408.2 UK € 1,217.2 € 424.3 DE € 959.6 € 414.1 FR € 771.9 € 410.2 Biosecurity measures 3 (1) EFSA, Zoonosis Report, 2020 (4) Anckorn et al., 2020 (2) Adlhoch et al., 2016 (5) Mangen et al., 2014 (3) FCC Consortium, 2010 (6) Pires et al., 2011 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No 773830. * Consideration of an underreporting factor (7.3)1 and a region specific source attribution factor6 Flow of processes Effect Risk BSM-specific risk ratio Reductions of human cases as well as prevalence reduction in pigs and associated monetary benefits will be considered provided sufficient data is available. Disease-associated economic effects play an important role in decision- making processes. Significant economic consequences have been identified as a result of pork-attributable human salmonellosis cases (approximately € 90 million annually in the European Union).3 In contrast, the monetary impact of HEV cases has not yet been determined. ►The present analysis evaluates the cost-effectiveness of specific BSMs proven to reduce the prevalence of Salmonella or HEV at specific stages along the pig production chain (PPC). The following demonstrates the concept behind the analysis. Effective biosecurity measures (BSM) along the production chain can reduce this impact. Therefore, the cost-effectiveness of applicable BSMs must be evaluated to support the establishment of national disease control programmes. The


The SwE Toolbox: a Toolbox for the Analysis of Longitudinal and Repeated Measures Neuroimaging Data Bryan Guillaume1,2, Xue Hua3, Paul M. Thompson3, Lourens Waldorp4, Thomas E. Nichols1 and the Alzheimer’s Disease Neuroimaging Initiative 1University of Warwick, Coventry, United Kingdom, 2University of Li`ege, Li`ege, Belgium, 3University of California, Los Angeles, USA, 4University of Amsterdam, Amsterdam, Netherlands. Introduction Neuroimaging software packages like SPM and FSL currently model longi- tudinal and repeated measures neuroimaging data using restrictive assump- tions. In particular, SPM assumes a common covariance structure for all the voxels in the brain and FSL assumes Compound Symmetry (CS), the state of all equal variances and all equal covariances. While more accurate meth- ods have been recently proposed to analyse such data [1,2,4,5,7,8], there remain few easy-to-use implementations of these methods. Here, we present an SPM toolbox allowing the use of the Sandwich Estimator (SwE) method, a fast, non-iterative tool for longitudinal and repeated measures data [5], and illustrate its use on data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Methods The SwE toolbox estimates parameters of interest using an Ordinary Least Squares (OLS) model and their variances/covariances using the so-called Sandwich Estimator [5]. The toolbox consists of a set of Matlab scripts de- signed to work in conjunction with the most recent versions of SPM (i.e. SPM8 or SPM12). The toolbox offers a user interface (Figure 1) allowing an easy speciﬁcation of the design and data, and a display of results similar to stan- dard SPM analyses. The use of the toolbox can be divided into 3 stages: the model setup, the model estimation and the display of results. The setup stage calls the Matlab batch system (Figure 1, top left) with a dedicated module for the SwE toolbox, which can be used to easily specify the data and design of the analysis. The second stage estimates the model. Finally, the third stage allows the speciﬁcation of contrasts of interest to make inference and display results (Figure 1, middle and right) in a similar way as standard SPM analy- ses. Regarding the inferences, the current release version of the toolbox only allows for the use of parametric uncorrected and voxel-wise False Discovery Rate (FDR) inferences based on results in [5]; methods for non-parametric uncorrected, FDR, and Family-Wise Error (FWE) inferences based on a Wild Bootstrap [9] resampling method are forthcoming. Here, we demonstrate the toolbox on a highly unbalanced longitudinal dataset (i.e. with many missing visits) consisting of Tensor Base Morphometry images obtained from the ADNI project, where 229 healthy elderly Normal control, 400 Mild Cognitive Impairment (MCI) and 188 Alzheimer’s Disease (AD) sub- jects were scanned up to 6 times over a period of 3 years [6]. As comparison, we also analyse the same dataset using 2 alternative methods: the Naive- OLS (N-OLS) method which includes subject dummy variables in an OLS model and assumes, by construction, Compound Symmetry (CS), and the Summary Statistic OLS (SS-OLS) method which ﬁrst ﬁts a regression model for each subject to obtain subject-speciﬁc estimates of the parameters of in- terest, and then computes a simple model on these summary measures. In addition, we conducted a Box’s test of CS [3] on the largest subset of the ADNI dataset without missing data to check the validity of the CS assumption. Results Figure 2 shows the Box’s test F-score image (centred at the anterior com- missure) thresholded at 5% after using a Bonferroni correction. 56% of the in-mask voxels survived the thresholding, indicating a strong evidence of non- Compound Symmetry in the brain and challenging the validity of the N-OLS method. Figure 3 and 4 show a comparison of thresholded t-score images (centred at the anterior commissure) obtained with the N-OLS, SS-OLS and SwE meth- ods on the difference in (lon


ceuci Desenvolvimento [urbano] baseado n o conhecimento, alinhado ao modelo "Triple Bottom Line" “Knowledge Cities”; Estratégia de gestão para áreas urbanas, baseada na Tripl a Hélice: desenvolvimen to econômico, social e ambiental Desenvolvimento econômico, social e espacial-urbano; Análise da atração e administração de indústrias e trabalhadores d o conhecimento, espaços urban os de alta qualidade Quádrupla e Quíntupla Hélice: participação da sociedade e sustentabilidade ambiental; KBUD permite que as cidades promovam desenvolvimento, inovação e qualidade d e vida através da colaboração universidad e-indústria-governo-sociedade 1995 “Three pillars of KBUD” Velibeyoğlu e Yigitcanlar 2000 2005 2010 2010 2013 Econômico Economia Baseada em conhecimento; Indústria de serviço; Indústria criativa; Indústria Verde ; Capacidade de Inovação; Empreendedorism o; Competitividade; Capital Financeiro Sociocultural Diversidade urbana; Tolerância; Coesão Social; Transparência e Responsabilidade; Qualidade d e Vida; Capital Humano e social; Capital Intelectual Urbano Desenvolvimento urbano sustentável; Infraestrutura urbana; Sistema de transport e inteligente; Sustentabilidade ecológica; Morad ia Social; Qualidade dos espaços; Identidade Urbana Institucional Planejamento Estratégico; Gestão da Infraestrutura; Gestão de Sistemas de Capital ; Gestão do Setor Público; Engajamento da comunidade; Participação Pública O ESTADO DA ARTE DO KNOWLEDGE-BASED URBAN DEVELOPMENT (KBUD): ANÁLISE DE QUADROS CONCEITUAIS (FRAMEWORKS) Bruno Borelli Liza, Silvia Stuchi, Marcela Noronha, Milena Pavan Serafim, Processo Fapesp nº 23/01212-3 No século XXI, transformações socioeconômicas, ambientais e tecnológicas têm impactado a vida urbana. Consequentemente, surgiram necessidades de novos mecanismos para promover o desenvolvimento urbano sustentável, tornando as cidades resilientes a tais transformações. O Knowledge-Based Urban Development (KBUD) é uma estratégia crucial neste contexto, partindo do princípio que a geração de conhecimento é vital para o desenvolvimento urbano sustentável e a competitividade econômica. Este trabalho visa identificar o estado da arte da literatura do KBUD, focando na análise de quadros conceituais (frameworks). INTRODUÇÃO MATERIAIS E MÉTODOS A metodologia envolve um mapeamento sistemático da literatura, uma revisão sistematizada e uma análise cronológica de quadros conceituais para identificar o estado da arte do KBUD. As etapas do protocolo de pesquisa incluem: pesquisa em bases de dados acadêmicos; snowballing da literatura; catalogação, filtragem e seleção final dos textos; fichamento, revisão e análise crítica. O mapeamento incluiu as bases Web of Science, Periódicos CAPES, Scopus e Google Scholar. Os frameworks mais relevantes para o tema das publicações foram extraídos, permitindo revisar as abordagens principais, notar mudanças nas perspectivas teóricas e práticas e identificar conceitos no campo do KBUD. Por fim, foi elaborado um estudo cronológico a partir dos principais quadros e abordagens identificadas na literatura do KBUD. A revisão cronológica das publicações permitiu identificar a evolução da pesquisa e prática do KBUD e dos frameworks, estruturas que organizam suas principais dimensões e indicadores. A interconexão entre tecnologia, inovação, economia, meio ambiente, governança e participação comunitária indica a necessidade de abordagens unidas e colaborativas para o desenvolvimento urbano sustentável. Inicialmente, o KBUD era visto como parte de uma estratégia de desenvolvimento econômico e sustentável (alinhado ao modelo "Triple Bottom Line"). Com a inclusão de novos conceitos e atores (em linha com os modelos de inovação de Quádrupla e Quíntupla Hélice), ele se expandiu para uma abordagem integrada e multidimensional. Finalmente, seus objetivos incluem: desenvolvimento econômico, sócio-cultural, espacial, ambiental e institucional, gerando prosperidade, equidade e sustentabilidade ambiental em uma cidade projetada


Knowing Unknowns in an Age of Incomplete Information Saurabh Khanna 1,  @saurabhk2701  saurabh.khanna@uva.nl Olga Eisele, Chei Billedo, Britta Brugman, Sandra Jacobs, Lauren Taylor, Marina Tulin, Marieke van Hoof 1 Amsterdam School of Communication Research, University of Amsterdam 🕯[In]visible The Internet has revolutionized our lives but also brought the challenge of invisible information — essential knowledge we miss out on. As algorithms prioritize content for maximizing consumption, we engage with only a fraction of relevant information. We intend to understand, quantify, and boost this hidden knowledge. 📸 PictoPercept PictoPercept is a visual survey tool that uncovers hidden preferences through rapid forced-choice tasks, revealing subconscious attitudes often masked by social desirability. 🗣 Lost Without Translation The Internet is a very unfair representation of human linguistic diversity. Lost Without Translation is an attempt to make these stark inequalities visible by quantifying and boosting online visibility for all living languages scripted by humans. 👁🗨 Shadowbans Shadowbans examines how shadow banning — hiding or de-emphasizing content without users’ knowledge — affects online information visibility and shapes digital interactions. 🦋 Beyond Words A majority of knowledge visible to us is built on communication among humans. Could we make the invisible visible by developing ways to communicate information effectively beyond our species? Beyond Words is an attempt to answer this challenging question. 🌍 32.5% humans still lack internet access 🤖 Information curated by for us to maximize understanding consumption 🙎♂ We are consistently consuming the tip of the information iceberg What can we do? 👉


Gut microbiota composition in Iberian pigs fed with olive oil by-products during the growing period M. Muñoz1,2, J.M. García-Casco1,2, G. Lemonnier3, D. Jardet3, O. Bouchez4, M.A. Fernández- Barroso1,2, F.R. Massacci3, A.I. Fernández1, A. López-García1,2, C. Caraballo1,2, E. González- Sánchez5, C. Óvilo1 and J. Estellé3 1INIA, Mejora Genética Animal, Crta. de la Coruña, km 7,5, 28040 Madrid, Spain, 2Centro de I+D en Cerdo Ibérico INIA-Zafra, Ctra Ex-101, km 4.7, 06300 Zafra, Spain, 3INRA, UMR1313 GABI, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France, 4INRA, US 1426 GeT-PlaGe, Genotoul, Castanet-Tolosan, France, 5Universidad de Extremadura, Escuela de Ingenierías Agrarias, Avda. Adolfo Suárez, s/n, 06007 Badajoz, Spain; mariamm@inia.es The traditional Iberian pig production system is characterized by a final open-air fattening period (montanera), in which the animals are fed acorns and grass, preceded by a growing period where the feeding is restricted to avoid undesirable weight gain. New growing diets based on olive agro-industrial by-products could be an alternative to avoid this restriction. The objective of the current study (of TREASURE project) was to analyse the effect of two growing alternative diets on the gut microbiota composition from faecal samples collected before and after montanera. Three diets, one incorporating dry olive pulp in the feed (DD), one incorporating olive cake in wet form (WD) and a control diet (CD) were supplied to 45 animals (15 per diet) during the growing period (45 to 95 kg of body weight). The gut microbiota composition of each individual was evaluated at two time points: before transition to montanera (95 kg) and at slaughter (160 kg). Microbiota analyses were performed by re-sequencing the bacterial 16S gene (V3-V4) in an Illumina MiSeq. Bioinformatics analyses were performed by using Qiime’s open-reference subsampled OTU calling approach. The effect of diets on microbiota composition and diversity was evaluated using the Vegan package in R. Bray-Curtis distances, NMDS and PERMANOVA analyses showed significant effects on microbiota composition. WD caused an increase in microbiota diversity. In the second sampling point, differences in composition and diversity could be also observed after acorn supplementation. Funded by European Union’s H2020 RIA program (Grant agreement no. 634476).


The HOOP project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement N°101000836. Technology #4 Insect larvae farmed on biowaste or agri-food by-products Innovation keys for the environment • Combination of larval rearing and waste management (potentially lucrative business). • Proteins production with a up to 10 times lower land use than meat proteins. (1) • Lauric acid produced from an alternative source to coco and palm seeds. • Alternative fertiliser as side-stream. Process flowchart Animal-free agrifood by-products Larvae   HoReCa Food waste(2) Pre-treatment  Larvae fattening biowaste reduction  Larvae sieving  Hygenization Drying Dried larvae  solid digestate    OFMSW(2) Sieving Fractioning Grinding   Protein hydrolizate  AD digestate(2)  Dewatering Frass  Lipids Larve meal (feed)  Chitin / Chitosan Legend: Biowaste feedstock Process input Process step Bioproduct Description Some insects can be safely included in feed and food formulations. Species like Tenebrio Molitor (yellow mealworm) and Hermetia Illucensis (black soldier fly - BSF) are farmed with different substrates, including residual streams of human food. Their bodies provide high-quality nutrients and chitin with a much lower environmental impact than traditional value chain processes. Moreover, their excreta (frass) is a valuable and marketable fertiliser. Biowaste feedstocks • Agri-food by-products • Brewery by-products • Market leftovers (animal free) • Households or HORECA food waste (2) • Digestate from anaerobic digestion (2) Market price [EUR] Business 2 Business or Business to customer Bioproduct(s) Market sector Market price Larval meal (grinded larvae) feed for domestic and exotic animal 10 €/kg for BSF [B2C] Livestock feed (cattle, aquaculture) 1.5-2 € / kg [B2B] Frass (larvae excreta) agriculture 30 € / ton [B2B] Hidrolised Insect Protein Livestock and pet feed 6’500 € / ton dry matter [B2B] Chitosan (from chitin) Agrochemicals, water treatment 40’000 – 50'000 € / ton [B2B] Fats / oils 1’600 € / ton [B2B] Lauric Acid Cosmetic 1'900 – 2'100 € / ton [B2B] Live larvae feed for domestic and exotic animal 7-8 €/kg [B2C]


Faculteit / departement Echoes of Yesterday An Exploration of Vintage Postcards Visit the project website The data Metadata ●Named entity tagging ●Geographic coordinates retrieval Image processing ●Image clustering ●Visual semantic search Website ●Visual semantic search engine ●Interactive map ●Exploratory analysis ●Tourism analysis Constrained by time, this project also acknowledges that the dataset has a lot to offer for future research. The analysis of dates on the postcards indicated that the majority of them date to a period between 1889 and 1922, but what would a detailed analysis of those dates bring? What would it say of the location as it stands today? Were the monuments and architecture on it destroyed in the World Wars? Is it protected as heritage today? An analysis of stamps on the postcards could perhaps offer an insight into changes in postal stamps over time, they could track tourism trends, locations, and people as they (postcards and persons) travel through Belgium. The existing images could also be used for creation of new images through the use of AI and Machine Learning models. Future research The team Tim Van de Cruys Benoît Cruciﬁx Ina Lamllari Lucia Allende Garrido Iva Stojevic Ivania Nadine Donoso Guzmán Yining Zhu Peiyang Huo Dawn Zhuang The Poststars team worked on the Postcards dataset, a collection of 19th and 20th century Belgian postcards. We analyzed 35,000 of the postcards, selected based on copyright restrictions. The postcards were collected in Belgium and depict various aspects of daily life, including places, monuments, and villages from that era. Echoes of Yesterday: an Exploration of Vintage Postcards is the webpage that created for this project. It features an interactive map that showcases the various locations represented on the postcards, along with an exploratory analysis on their publication and distribution. Additionally, there is a tourism analysis based on image clustering. What's particularly intriguing is that users are able to search through the postcard collections using keywords via the search engine on the website. Methodology The dataset consists of image ﬁles and metadata for each individual postcard. Uniform titles in the metadata were tagged with wikineural named entity tagging model, as the index for geographic coordinates retrieval from openstreetmap data. CLIP (Contrastive Language Image Pre-Training) is a pre-trained neural model that learns to recognize the relationship between language and images. By encoding our dataset as CLIP embeddings, we can use the model for visual semantic search.


Introduction Young-Woo Seo1, Won-Jae Lee1, Young-Joo Kim1, Sun-Ok Chung1*, Young-Kyun Jang2, Seung-Ho Jang2 , Im-Sung Bae3 , College of Agriculture and Life Sciences, Chungnam National University, Republic of Korea1, Shinan Green-Tech Co., Ltd, Suncheon, Cheonnam 58027, Republic of Korea2, Green Control System Co., Ltd, Gwangju 61027, Republic of Korea3 Temperature/humidity in greenhouse Automatic or manual control in set value Real-time, visible at a glance Low error rate, responsible Materials and Methods Results and discussion Conclusions System block diagram • Sensor node : Sensors + ZigBee • Control node : ATmega128 + ZigBee + Relay Design and Construction of a Remote Monitoring and Control System for a Dehumidifier combined with a Heating Module Block diagram of monitoring and control system Developed sensor and control interface monitoring program Review of the results  Average error = 0.28 ˚C in the target temperature  Average error = 0.99% in the target humidity Temperature(left) and humidity(right) control experiment graph Target Temperature Average and Standard deviation 30 ˚C 29.9±0.28 ˚C 30.51±1.05 ˚C Target Humidity Average and Standard deviation 70% 70.7±0.99% 69.9±1.25% Average and standard deviation on temperature control experiment Average and standard deviation on humidity control experiment Acknowledgement Developed sensor and control interface module(Left), Location of the sensor nodes used in the experiment(Right) This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries(IPET) through Advanced Production Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA)(Project No. 316082-03) Control Systems Receive data in real-time Auto/manual control Save files in .xls or .txt format Dehumidifier Control Schematic of the main control system Improvement factors  More and various sensors input in need  Further test under crop growing conditions  Control algorithm


Comment faire partie de l’EOSC ? Il existe de nombreux points d’accès vers l’environnement EOSC, couvrant un large spectre de communautés de recherche thématiques ou régionales, ainsi que diﬀérentes façons de s’impliquer dans la gouvernance de l’EOSC. C’est le cas de l’EOSC Association, au sein de laquelle les organisations de recherche en Europe peuvent s’impliquer: eosc.eu. Qu’est-ce que l’EOSC? L’EOSC est une démarche visant à construire un environnement virtuel pour les infrastructures de données scientiﬁques existantes. L’objectif est de rendre les données de recherche, les outils et les services associés plus faciles à trouver, à accéder et à réutiliser. L’EOSC vise également à interconnecter et combiner les jeux de données entre disciplines et au-delà des frontières, aﬁn de rendre possible des découvertes inattendues. Comment les chercheurs peuvent-ils en proﬁter? Un premier bénéﬁce pour les chercheurs est l’accès facilité aux données, publications, outils et services. Vous pouvez également tirer avantage des données réutilisables, d’une plus grande visibilité pour votre recherche, et d’un accès aux services dédiés à la recherche mis à disposition par les meilleurs fournisseurs de service Européens à travers le portail EOSC: eosc-portal.eu. Comment les chercheurs peuvent-ils s’impliquer? Rendez vos données trouvable, accessibles, interopérables et réutilisables (FAIR). Utilisez les outils et données à travers l’EOSC pour augmenter sa visibilité. Impliquez-vous dans la gestion des données de recherche. Rejoignez le programme des ambassadeurs EOSC: eosc-pillar.eu/ambassadors-programme! Connecting Research Across Europe and Beyond Ambassadors Programme L’EOSC (European Open Science Cloud, Cloud Fédéré Européen pour la Science Ouverte) a un rôle important à jouer dans la façon dont travaillent les chercheurs en Europe. En facilitant le partage et la réutilisation des résultats de recherche et des données, l’EOSC a un impact positif non seulement sur la science, mais sur l’ensemble de la société. Etes-vous prêts à soutenir votre réseau et votre institution dans leur implication dans l’EOSC? Contribuez au Cloud Fédéré Européen pour la Science Ouverte Etes-vous intéressés par la science ouverte ? Faites connaitre l’European Open Science Cloud (EOSC) – et montrez aux chercheurs, étudiants et décideurs de votre institution comment proﬁter de l’EOSC et comment s’impliquer ! Si vous souhaitez plus d’informations sur le programme d’ambassadeurs EOSC-Pillar, EOSC-Pillar has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 857650. contactez-nous


Das Text+-Langzeitarchiv: Eine generische Lösung für den nachhaltigen Erhalt von Daten in den Geisteswissenschaften George Dogaru Gesellschaft für wiss. Datenverarbeitung mbH Göttingen (GWDG) • Das Text+-Langzeitarchiv soll 2023 an den Start gehen. Es wird im Rahmen der Measure 2 in der Text+ Task Area Infrastructure/Operations durch die GWDG, die SUB Göttingen und die DNB realisiert. • Es adressiert den grundlegenden Bedarf nach einer Infrastruktur für den langfristigen und sicheren Erhalt von Daten mit geisteswissenschaftlichem Bezug. • Es wird das unkomplizierte Archivieren ermöglichen, ohne Einschränkung des Datenformats. • Es wird bitstream preservation bieten sowie PIDs. • Sowohl offene als auch geschützte Archivbereiche werden möglich sein. Das Text+-Langzeitarchiv (provisorischer Name) Spezialisierung Daten mit geisteswissen- schaftlichem Bezug Modalität Alle (keine Einschränkung) Akzeptierte Datenformate Alle (keine Einschränkung) Ansprech- person(en) George Dogaru (george.dogaru@gwdg.de) Das NFDI-Konsortium Text+ wird gefördert durch die Deutsche Forschungsgemeinschaft (DFG) unter der Projektnummer 460033370. CDSTAR § Repository-Software § die Interaktion mit dem Langzeitarchiv erfolgt ausschließlich über CDSTAR § bedienbar über eine REST-API, § sowie über eine einfache eigene Web-basierte GUI mit komfortablen Möglichkeiten zum § Hochladen § Vergeben von Metadaten § Suchen § Herunterladen § kann die Daten ins Langzeitarchiv übertragen und vom Archiv holen § aber auch die Daten bereithalten, wie ein Repository § es lassen sich sowohl offene als auch geschützte Archivbereiche realisieren CDSTAR-Koala-Connector § aktuell in Entwicklung § übersetzt zwischen dem internen CDSTAR- und dem internen Koala-Format § übergibt die Daten von CDSTAR an Koala und umgekehrt Koala § Software für Langzeitarchivierung § sorgt für die effiziente und sichere Übertragung der Daten aus dem/in den Storage, für die dauerhafte Integrität der Daten § die Langzeitarchivierungslösung der Deutschen National- bibliothek basiert auf Koala Architektur, Features, Bedienung Langzeitarchiv vs. Repository Anders als Repositories, die ihre Daten für die sofortige Nutzung bereithalten, dient ein Langzeitarchiv der langfristigen Aufbewah- rung von Daten, die möglicherweise nicht häufig abgerufen oder aktiv genutzt werden. Eine doppelte Nutzung des Text+-Langzeit- archivs als Archiv und als Repository wäre technisch möglich. CDSTAR- Koala- Connector Text+ could help facilitate the work of OPERAS [...] as a service that stores sensitive data [...] Most urgently needed would be a reliable central and long-term storage of the conducted data […]. This would not only facilitate the work of all project partners as they would not need to think about how to store this data, it would also be centrally available to everyone with access rights throughout the project and after if the project’s grant agreements require it. https://www.text-plus.org/en/research-data/user-story-311/ OPERAS – open scholarly communication in the european research area for social sciences and humanities Text+ could provide a repository for long term archiving of the data. https://www.text-plus.org/en/research- data/user-story-334/ The history of the “Deutschland-Institut” in Beijing (1932–1950): an example for Sino-German academic collaboration Getting researchers to get their valuable research data to a long-term archive is hard, so we need to lower the barrier to archive/publish research data. https://www.text-plus.org/en/research- data/user-story-351/ Data Archiving Support Creating an institution for securing and making available our research data for the long term is a matter of existential importance for the future of our discipline. The information we generate (and which should be saved for the long term) could be interconnected with databases of other German institutions, which otherwise might get lost. https://www.text-plus.org/en/research-data/user- story-342/ Epigraphy at the BBAW


Calibrating the lithium-age relation and its dependence with rotation, activity and metallicity using open clusters and associations Acknowledgments: Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme focus ID 188.B- 3002. These data have been obtained from the GES Data Archive. This work has made use of data from the European Space Agency (ESA) mission Gaia. We acknowledge financial support from the Universidad Complutense de Madrid (UCM) and by the Spanish Ministerio de Ciencia, Innovación y Universidades, Ministerio de Economía y Competitividad, from project AYA2016-79425-C3-1-P and PID2019-109522GB-C5[4]/AEI/10.13039/501100011033. Preliminary results: dependence with rotation, activity and metallicity. Li-age relation Candidate members for each cluster are selected from the Gaia-ESO Survey (GES) (Gilmore et al. 2012) iDR6 data based on the following criteria: RVs, Gaia astrometry (proper motions and parallaxes), gravity indicators - Kiel (logg vs Teff) and 𝛾index diagrams, [Fe/H] metallicity, and the position in the EW(Li) vs Teff diagram. As an example we show here the case of IC 2602 (RV, PMs, CMD, EW(Li) vs Teff and 𝛾index) and NGC 6705 (Kiel diagram and [Fe/H] histogram): Selection criteria and cluster membership Abstract EW(Li) vs Teff: Plotting the lithium envelopes of IC 2602 (35 Myr), the Pleiades (78-125 Myr), and the Hyades (750 Myr) in a EW(Li) vs Teff figure, we can estimate age ranges and verify probable members (see Montes et al. 2001). Kinematic selection: We studied the RV distribution of each cluster by applying a 2-sigma clipping procedure and adopting a 2σ limit about the cluster mean yielded by the Gaussian fit to identify the most likely RV members. The Kiel diagram enables us to discard giant outliers (logg < 3.5) – some of them Li-rich giants (A(Li) > 1.5) – and other field contaminants. We used the PARSEC isochrones (Bressan et al. 2012), with Z = 0.019 and ages ranging from 1 Myr to 7 Gyr. For young clusters, we used the gravity indicator gamma (see γ index vs Teff diagram above) to discard giant contaminants before applying any kinematic and astrometric criteria,. Star Clusters: The Gaia Revolution MW Gaia WG 1/2 online workshop 5-7 October 2021 [Fe/H] histograms also help rule out stars with metallicities too far away from the mean for each cluster. M.L. Gutiérrez Albarrán1, D. Montes1 , H.M. Tabernero1,2, J.I. González Hernández3,4, A. Frasca5, A.C. Lanzafame5, R. Smiljanic6, A.J. Korn7, S. Randich8, G. Gilmore9, et al. & GES Survey Builders 1Departamento de Física de la Tierra y Astrofísica and IPARCOS-UCM, Facultad de Ciencias Físicas, Universidad Complutense de Madrid, E-28040, Madrid, Spain; 2 CAB; 3 IAC; 4 Universidad de la Laguna, Tenerife; 5 INAF Catania; 6 Nicolaus Copernicus Astronomical Center; 7 Department of Physics and Astronomy, Uppsala University; 8 INAF Arcetri; 9 Institute of Astronomy, University of Cambridge In this work we use a series of open clusters and associations observed by the Gaia-ESO Survey (GES) to study the use of lithium abundances (Li I spectral line at 6708 Å) as an age indicator for pre- and main-sequence FGKM late-type stars. Previous studies of open clusters have shown that lithium depletion is not only strongly age dependent, but also shows a complex pattern with several other parameters, such as rotation, chromospheric activity and metallicity. Using the available data from both GES iDR6 and Gaia EDR3, we performed a thorough membership analysis and obtained lists of candidate members for 41 open clusters, ranging in age from 1-3 Myr to 5 Gyr. We then conducted a comparative study that allowed us to quantify the observable lithium dispersion in each cluster and study influence of rotation, activity and metallicity in the lithium dispersion of the selected candidates. All this allows us to calibrate a Li-age relation and create empirical lithium envelopes for several clusters in our sample.


1. Radio relics Relics are elongated Mpc-size radio sources located in the outskirts of merging galaxy clusters. These radio relics trace merger shocks where particles are accelerated to relativistic energies, causing them to emit at radio wavelengths. It is still being debated by which physical mechanism these particles are accelerated. Reinout van Weeren, Felipe Andrade-Santos, Christine Jones, William Forman, Georgiana Ogrean Harvard-Smithsonian Center for Astrophysics Probing the Physics of Particle Acceleration at ICM Shocks Subaru gri 150 MHz LOFAR radio 0.5 – 4.0 keV Chandra 2. Shock Mach number Particle acceleration models make predictions about the relation between shock Mach number and the observed radio spectral index. However, existing X-ray observations lack the sensitivity to measure the Mach numbers at large cluster centric radii with high- accuracy to test these models. 3. A case study A textbook example of a radio relic is the one in the cluster RXJ0603.3+4214 (z=0.225). In a 240 ks Chandra observation a hint of a weak M~1.4 shock is found at the location of the relic, by measuring the X-ray surface brightness jump. No useful constraint could be obtained on the pre- shock temperature. 5. Conclusion X-ray Surveyor observations will enable precise measurements of low-Mach number shocks in cluster outskirts both via the density and temperature jump, crucial for testing particle acceleration models. X-ray Surveyor simulated (hdxi, 100 ks) Chandra observed (ACIS-I, 240 ks) Radio Relic pre-shock region post-shock region 4. X-ray Surveyor simulations Based on the Chandra count rate and measured ICM properties, we simulated an X-ray Surveyor observation of a Mach = 1.4 shock with, a post-shock temperature of 9 keV. We determine the shock Mach number from the surface brightness profile and via measurements of the pre- and post-shock temperatures. References: van Weeren et al. (2010, Science, 330, 337); van Weeren et al. 2012 (A&A, 546, 124); van Weeren et al. 2015 (ApJ, submitted); Dawson et al. (in prep); Eckert et al. (2011, A&A, 526, 79); Ogrean et al. (2013, MNRAS, 433, 812) 900 kpc 4 arcmin 0.5-4.0 keV 0.5-4.0 keV X-ray Surveyor simulated pre- and post-shock spectra (calorimeter, 100ks) Tpre-shock = 5.9 ± 0.3 keV (model T=6.4 keV) Tpost-shock = 8.8 ± 0.2 keV (model T=9.0 keV) Mach number = 1.5 ± 0.1 (model M=1.4) Mach number = 1.38 ± 0.03 (model M=1.4) Mach number = 1.4 ± 0.3 (observed) Observed and simulated surface brightness profiles across the relic RX J0603.3+4214 Redshift (0.225) and Abundance (0.25) were frozen in the fit, nH was left as a free parameter. Double power-law projected density profile fit with a jump Subaru image: William Dawson, Nathan Golovich


. Discovery of Low-ionization Envelopes in the Planetary Nebula NGC 5189 Spatially-resolved Diagnostics from HST Observations Ashkbiz Danehkar, Margarita Karovska, W. Peter Maksym, and Rodolfo Montez Jr. Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138, USA The planetary nebula NGC 5189 shows one of the most spectacular morphology among planetary nebulae. Using high-resolution HST/WFC3 imaging, we discovered the low-ionization structures within 0.3pc × 0.2pc around the central binary system. We used Hα, [O III] , and [S II] emission line images to construct line-ratio diagnostic maps, which allowed us to spatially resolve two distinct low-ionization envelopes within the inner regions. Our diagnostic maps show that highly-ionized gas surrounds these low-ionization envelopes. These envelopes could be a result of a powerful outburst from the central interacting binary, when one of the companions (now a [WO] star) was in its AGB evolutionary stage. Dense material ejected from the progenitor AGB star is likely heated up as propagating along a symmetric axis into the previously expelled material. Our diagnostic mapping using high-resolution imaging can provide a novel approach to detection of low-ionization regions in other planetary nebulae and in other objects including symbiotic systems and expanding envelopes of novae. References Baldwin, Phillips, Terlevich, 1981, PASP, 93, 5 Danehkar et al. 2018, ApJ, [arXiv:1711.11111] Garcia-Rojas et al. 2012, A&A, 538, A54 Kewley et al. 2006, MNRAS, 372, 961 Acknowledgment E-mail: ashkbiz.danehkar@cfa.harvard.edu Spatially-resolved Flux Ratio Maps Resolved Diagnostic Mapping [S II]/Hα flux ratio: high in low-excitation regions [O III]/Hα flux ratio: high in high-excitation regions FIG 1. Image with specific colors of fluorescing sulfur, hydrogen, and oxygen. Credit: NASA/ESA Hubble Space Telescope (Dec 18, 2012). FIG 4. Spatially-resolved diagnostic map of the inner region of NGC 5189. Red and green pixels correspond to low-ionization and photo-ionized regions, respectively. FIG 5. Excitation diagnostic diagram and BPT diagram produced from the 120" × 90" region of NGC 5189 to disentangle fast LISs from photoionized regions. Solid black lines: LINER-like and Seyfert-like boundaries (Kewley+2006), solid red line: nebular photon-shock dividing line (Raga + 2008), star (∗): the mean flux ratios, cross (×): Garcıa-Rojas+2012, and plus (+): Kingsburgh & Barlow (1994). Kingsburgh & Barlow 1994, MNRAS, 271, 257 Maksym et al. 2016, ApJ, 829, 46 Raga et al. 2008, A&A, 489, 1141 Sabin et al. 2012, RMxAA, 48, 165 Main Findings and Future Prospects Two low-ionization envelopes within the inner, ionized gaseous environment, extending over 0.15pc from the central star. Both appear to be expanding along a NE to SW axis. The SW envelope appears smaller than its NE counterpart. These low-ionization envelopes are surrounded by the highly ionized, low-density gas. Our diagnostic methodology is a powerful tool for identifying low-ionization structures in other objects, e.g. complex planetary nebulae, expanding nebulae around symbiotic systems and expanding shells of novae (e.g. V445 Puppis). Diagnostic diagrams based on [O III]/Hα vs. [S II]/Hα ratios Dividing Shock-ionized and Photoionized regions (Raga + 2008) Similar to LINER and Seyfert regions (e.g. Maksym + 2016) in BPT diagrams (Baldwin, Phillips & Terlevich 1981; Kewley + 2006) Shock-ionized Structures within Photoionized Nebula FIG 3. Logarithmic flux [S II]/Hα ratio map of the 120" × 90" region chosen from the HST observations. Two main morphological structures are labelled 120 ” 90” FIG 2. Logarithmic flux [O III]/Hα ratio map of the 120" × 90" region chosen from the HST observations. The contour lines show the boundaries of photo-ionized and low-ionization regions. Two main morphological structures are labelled. We are grateful to Mr. Zoltan Levay and the Hubble Heritage Team who have obtained the NGC5189 HST da