I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 Design of a parallel device for neurorehabilitation Jawad Yamine∗, Alessio Prini†, Tito Dinon†, Hermes Giberti‡ and Matteo Malosio† ∗Dipartimento di Meccanica, Politecnico di Milano, via La Masa 1, 20156 Milano, Italia Email: jawad.yamine@mail.polimi.it †Istituto di Sistemi e Tecnologie Industriali per il Manifatturiero Avanzato, Consiglio Nazionale delle Ricerche via Alfonso Corti, 12, 20133 Milano, Italia Email: alessio.prini@stiima.cnr.it, tito.dinon@stiima.cnr.it, matteo.malosio@cnr.it ‡Dipartimento di Ingegneria Industriale e dell’Informazione, Universit`a di Pavia, Via A. Ferrata 5, 27100 Pavia, Italia Email: hermes.giberti@unipv.it Abstract—This paper presents the mechanical architecture and the design of a 2DOF parallel device for upper-limb neurorehabil- itation. Geometric parameters have been obtained by optimizing kinematic performances. The prototype has been designed so that it can be bound on one side of a table with a clamp. The structure embeds two single-point load cells to measure the force exchanged with the patient, and to allow the execution of assist-as-needed therapies. Index Terms—Parallel kinematic architecture; kinematic op- timization; rehabilitation robotics; assist-as-needed control algo- rithms. I. INTRODUCTION Stroke is one of the main causes of long-term disability in the world and the most common in Western countries [1]. The number of patients having difﬁculties in performing activities of daily livings due to physical disabilities is constantly increasing while the number of therapists and caregivers is increasingly inadequate, creating an unmet market need. Robotic devices for neurorehabilitation have been widely investigated, developed and introduced to the market to offer an alternative to conventional therapy and meet a portion of the created need [2], [3]. Since the invention of the MIT-Manus [4], robot-assistance, force-feedback and force-based control are stat-of-the-art features of neurorehabilitation devices [5], enabling them to sense and react to patient interactions with the robot and adapt the level of physical assistance provided to the patient. Most of the proposed robots are technically advanced, but relatively expensive and designed for clinical settings, which makes it hard for patients to afford such treatment. On the other side, and focusing on upper-limb rehabilitation, a number of low-cost rehabilitation devices are currently available, but they are typically passive or passively gravity-balanced [6]. The lack of actuation and of an assist- as-needed support precludes them to be effectively used by patients with low-medium motion capabilities. Therefore, there is still a signiﬁcant need to develop home- based devices that provide similar or better functionality for a reduced cost. From there, rises the idea of our project that consists of designing and implementing a planar and relatively This work was partially funded by Fondazione Cariplo within the EMPA- TIA@Lecco project, Rif. 2016-1428 Decreto Regione Lombardia 6363 del 30/05/2017. affordable home-based upper-limb rehabilitation device that offers assist-as-needed functionalities to give the patient the best rehabilitation experience. Focusing on planar robotic devices for neurorehabilitation, two of them stand out in literature: the MIT-Manus [4] and the Braccio di Ferro [7]. A negative aspect of their structure is that both of them are characterized by a distribution of the inertia ellipses which are not symmetric, with respect to the sagittal plane of the patient. Zollo et al. faced this issues by developing a planar orthogonal device, characterized by an isotropic behavior throughout the whole workspace [8]. Nevertheless, in the opinion of the authors, such architecture is relatively cumbersome and complex to allow an effective commercial exploitation, especially in the domestic environment. For these reasons, a new device, namely PLANarm2, b


DDI 4 Class Library (301 classes) as XMI R6Class source code R functions source code DDI2 to DDI4 mapping table DDI 4 Prototype is implemented as a model. This translates well into objected‐oriented software like Integrating Lifecycle Metadata into the R workflow – Implementing DDI4 in R Capturing, reporting on, and computing on metadata at the source Initial Work – Developing the Infrastructure User Interface not available yet, will be next step IASSIST Conference 2019, Sydney, Australia, May 27‐31, 2019. Joachim Wackerow, GESIS ‐ Leibniz Institute for the Social Sciences; Larry Hoyle IPSR, University of Kansas This work is licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0). ‐ Email: joachim.wackerow@gesis.org; larryhoyle@ku.edu XSD OWL/RDF‐S XML RDF Discovery and interoperability Transformation to DDI Alliance default syntax representations Purpose Exchange and preservation DDI4_Code. A type of Designation that relates a representation expressed as a string with or without meaningful white space to a specific classification Description Implementation of the DDI4 class Code Definition ============ A type of Designation that relates a representation expressed as a string with or without meaningful white space to a specific classification. For use in a Code List. The representation property (Value) is expressed as it would be found in a data file. Multiple representations may relate to the same Category but should be expressed as separate Codes. Help in R ‐ ?DDI4_Code Transparency and replication are crucial for open science • Capture metadata at the earliest point possible • Building this into the scientific workflow • means making tools available in the platforms people use • Attach the metadata to the data to travel together • Especially important for tables and variables • Example: unit of measurement, scale, precision • When a variable is created, this has to be known. Attach it to the variable. • Operating on Metadata • Harmonization procedures Metadata in the Statistical Package Workflow Transformation by program DDI4Contents.equal(CodeListA, CodeListB) DDI4R code fragment for comparing two Codelists on equality of content Documentation In the UML Model Classes in the UML Model of DDI4 • Built‐in validation of imported metadata • Capturing correct metadata on the fly • Fetching remote DDI resources • Functions for comparison and harmonization of metadata Features in DDI4R Classes in R str(DDI4_Code) Class 'R6ClassGenerator' <DDI4_Code> object generator Inherits from: <DDI4_Designation> categoryDescription <- DDI4_InternationalStructuredString$new(languageSpecificStructuredString=  list(DDI4_LanguageSpecificStructuredStringType$new(content="Male"))) myCategory <- DDI4_Category$new(descriptiveText=list(categoryDescription )) myCode <- DDI4_Code$new(denotes=myCategory$DdiUrn,  representation=list(DDI4_ValueString$new(content="M"))) Category="Male" Code="M" DDI4R code fragment for: R package DDI4R A class is a template for an object.


Niki Messini1,2, Joel Roca-Martínez3, Nitin Kachariya1,2, Paola Redeghieri4, Anahí Higuera5,6, Francisco Morales4, Mireille Dumoulin4, Wolfgang Kaiser6, Wim Vranken3, Michael Sattler1,2 1 Bayerisches NMR Zentrum, Technical University of Munich, Garching, Germany 2 Institute of Structural Biology, Helmholtz Zentrum Munich, Neuherberg, Germany 4 Center of Protein Engineering, University of Liege, Belgium 3 Vrije University of Brussels, Belgium 5 Physics Department, Technical University of Munich, 85748 Garching, Germany 6 Dynamic Biosensors GmbH, Lochhamer Str. 15, 82152 Martinsried, Germany [1] J. Hennig, Nature 2014. [4] Y. Shamoo, Nucleic Acids Research 1995. Understanding and designing RNA binding specificity of the RRM domain The RNA recognition motif (RRM) is the largest family of RNA binding domains, and fulfills crucial roles in gene regulation. The canonical RRM fold has a β-α-β-β-α-β-β secondary structure, harboring two conserved ribonucleoprotein (RNP) sequence motifs, RNP1 and RNP2, in β3 and β1, respectively. Canonical RNA binding usually involves the RRM β-sheet, but many variations of RRM-RNA interactions are seen. Although numerous three-dimensional structures of RRM domains in complex with RNA are known, the RNA recognition code of RRM domains remains poorly understood. We combine computational approaches with experimental methods to identify key residues and their role for defining RNA binding specificity. The Sex-lethal protein (Sxl) from Drosophila Melanogaster is used as a model system, to redesign the RNA binding specificity of one of its two RRM domains. Binding kinetics and thermodynamic features are analyzed by NMR, ITC and switchSENSE® experiments, which show distinct on- and off-rate binding kinetics for the Sxl RRM domains, and significant binding preference for RNA over DNA. Computationally, a carefully curated multiple structure-based sequence alignment was analyzed to reveal residue-nucleotide preferences on a set of RRM-RNA complexes. This information is translated into a score to predict RNA binding preferences for millions of theoretical mutants. To enhance the scoring and improve its accuracy, phage display selection from a large combinatorial library of RRMs is used as an experimental validation of the approach, with the results validated by Bio-Layer Interferometry, NMR and further biophysical techniques. 1:00 1:0.25 1:0.5 1:0.75 1:1.0 1:2.0 Molar ratio Sxl RRMs show binding preference for RNA over DNA Distinct RNA binding preference and kinetics for RRM1 and RRM2 9 9 9 9 9 9 9 9 1 2 3 4 5 6 7 8 9aa mutations for 8 positions 89 mutants Designing novel RRMs by random mutagenesis and computational predictors Computational predictors • Expression of the synthetic DNA library with large number of RRM1 mutants at the surface of phages and selection of those specific of the target RNA by panning N Q D E R H K S T X01 (N) 7% 2% 27% 59% 2% 0% 0% 0% 2% X02 (N) 24% 17% 0% 5% 17% 2% 29% 5% 0% X03 (T) 2% 2% 2% 0% 7% 20% 51% 12% 2% X04 (R) 17% 2% 0% 2% 10% 27% 34% 0% 7% X05 (D) 54% 2% 12% 7% 17% 0% 5% 2% 0% X06 (K) 0% 15% 0% 0% 12% 20% 51% 0% 2% X07 (S) 7% 10% 22% 0% 15% 7% 17% 22% 0% X08 (R) 5% 37% 0% 10% 15% 7% 24% 2% 0% WT1: GUU GUU (4x) WT2: UUU UUU (4x) CCC CCC (4x) AAA AAA (4x) UUAGGA(4x) strong binder strong binder no/weak binder strong binder strong binder RRM1 +GUUGUU (4x) WT1: GUU GUU (4x) WT2: UUU UUU (4x) CCC CCC (4x) AAA AAA (4x) UUAGGA(4x) strong binder moderate binder no binder weak binder no/weak binder Computational predictors RRM2 RNA Anchor RRM1 Novel RRM • Design and modulate RRM-RNA binding preference • Sxl RRM1-RRM2 as a model system • RNA specificity of individual domains • Identify key positions in the RRM fold that mediate RNA binding specificity using 1) computational analysis and 2) random mutagenesis of key positions in RRM1, using RRM2 as “anchor” • Phage display selection of specific binders for RNA targets Novel RRMs • SXL RRM1,2 binds with higher affinity to RNA compared to


Convertio Measure 3.2: Agrosystem Templates for Easy Data Management Plan Creation Data Management Plans Budget planning Benefits Project management Challenges ●Requires know how on Research Data Management topics ●Costs resources DFG Horizon Europe Other funders Customized agrosystem templates ●Answer options ●Help texts ●Links to other FAIRagro services ●Available via RDMO (DMP tool) ●What are your requirements towards DMPs? ●How can we improve the templates? We need your feedback! Follow the QR code and let us know what you need Antonia Leidel1, Gabriel Schneider2 1 - Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), 2 - Information Centre for Life Sciences (ZB MED) ...


Courses, Events and Workshops Plazi analysts have been giving a number of training courses over the recent years. The training courses are tailored to the audience and their general objectives for data to be liberated and made available. Synospecies A linked open data based service to leverage taxonomic names, its synonyms and its justification through access to the respective taxonomic treatment. eBioDiv Matching Service The crowdsourcing tool allows users to match material citations contained in the academic literature to the respective specimens in natural history collections (in GBIF). Helpdesk Users can interact with the helpdesk service by creating issues on Plazi’s Community Github repo and find answers to FAQs. TreatmentBank Plazi’s service to liberate taxonomic information and provide access to all the liberated data and links. How to contribute to liberate taxonomic data from scientific publications, make them FAIR, and widely available Taxonomic publications contribute to a continually updated corpus of over 500 million pages of research results and the best expert curated datasets, including the entire history of taxonomic names. To harness its power, the data needs to be liberated, that is, converted into digitally accessible knowledge. Donat Agosti President agosti@plazi.org Bern, Switzerland ORCID: 0000-0001-9286-1200 CC0-DA/Bern, July 18, 2024 312848 308454 Training course at the University of Pretoria, South Africa, 2023 Jonas Castro Data Quality Analyst castro@plazi.org Porto Alegre, Brazil ORCID: 0000-0002-7403-409X Plazi Workflow images refs </> metadata tables Taxonomic treatments Biodiversity PMC Provides information retrieval across life science literature (MEDLINE, PMC), biodiversity publications and treatments. LIBERATING DATA IMPRISONED IN TAXONOMIC PUBLICATIONS Minimally, this includes machine actionable, semantically enhanced taxonomic treatments, taxonomic names, treatment citations, figures, tables, material citations and bibliographic references as Findable, Accessible, Interoperable, and Reusable (FAIR) data. Plazi provides a workflow to annotate and extract case by case or fully automated data from target or corpora of publications respectively. VISUALIZATION OF DATA IN PUBLICATIONS Plazi Verein and Plazi GmbH form the Swiss based nonprofit organization Plazi, supporting and promoting the development of persistent and openly accessible digital taxonomic literature. Our production facility at Porto Alegre, Brazil, runs all aspects of processing publications, development of learning tools and dashboards creation. MAKING TAXONOMIC DATA FINDABLE AND ACCESSIBLE AT SCALE: TREATMENTBANK ACCESS TO LIBERATED DATA AND LINKS SERVICES REUSING LIBERATED DATA Global Biodiversity Information Facility (GBIF) GBIF is including in its aggregation process taxonomic articles as datasets, taxonomic treatments, taxonomic names and materials citations. Ocellus A frontend to search liberated figures in BLR World Flora Online WFO is linking taxonomic names to treatments, using TreatmentBank and soon on an automated service to add to new incoming treatments. 15 years of discovering known biodiversity PLAZI Biodiversity Literature Repository (BLR) In collaboration with Zenodo, BLR allows FAIRization of treatments and figures by minting DataCite DOIs, and long term storage and preservation of the data. Annotated and FAIRized data can be used to evaluate a botanist's contribution to science, the scope or reach of a scientific journal, the biodiversity present in a given area, among various other practical applications. HOW TO PARTICIPATE IN DATA LIBERATION Visualization of Jocélia Grazia’s contribution to taxonomy Introduction to data annotation and FAIRization An introduction and learning material is provided leading to a certification enabling contributing to growing FAIR data using the Plazi workflow. Statistics for 2024-07-18 Poster #229 DOI:10.5281/zenodo.12764847 European Nucleotide Archive Notebooks related with bio


Brea Tessaria absinthioides Los humedales son uno de los ambientes con mayor diversidad biológica y productividad en el mundo. A través de esta guía te invitamos a descubrir y apreciar algunas de las fascinantes especies de flora y fauna que habitan en los cercanos y valiosos humedales y cuencas de la bahía de Coquimbo. De norte a sur, se localizan la Laguna Saladita de Punta Teatinos, el humedal desembocadura río Elqui, el humedal Quebrada de Peñuelas y el humedal Estero El Culebrón. Además, encontrarás información sobre las contribuciones de los humedales al bienestar humano, sus principales amenazas, hitos en la protección de estos ecosistemas en Chile, junto con información sobre el turismo sustentable y acciones para proteger los humedales. Aquí se presenta información resumida de 112 especies que puedes encontrar en estos humedales y sus cuencas, con 6 grandes grupos de flora y fauna: 11 especies de flora, 20 de artrópodos, 11 de mamíferos, 9 de reptiles, 2 de anfibios y 59 de aves*. Esta guía fue co-producida entre múltiples organizaciones, instituciones y personas voluntarias que aportaron con información, fotografías e ideas. Esperamos que este material contribuya a mejorar tu experiencia durante la visita a los humedales de la bahía de Coquimbo y a profundizar tu vínculo con estos ecosistemas. FLO RA AVES AR TRÓ PODOS ANFIBIOS/ REPTILES MA MÍ FEROS Orden: Araneae Familia: Araneidae Orden: Diptera Familia: Ulidiidae Orden: Asterales Familia: Asteraceae Orden: Charadriiformes Familia: Charadriidae Orden: Charadriiformes Familia: Laridae Orden: Charadriiformes Familia: Laridae Orden: Charadriiformes Familia: Haematopodidae Orden: Charadriiformes Familia: Scolopacidae Orden: Charadriiformes Familia: Laridae Orden: Charadriiformes Familia: Laridae Orden: Charadriiformes Familia: Charadriidae Orden: Charadriiformes Familia: Charadriidae Orden: Charadriiformes Familia: Scolopacidae Orden: Charadriiformes Familia: Scolopacidae Orden: Charadriiformes Familia: Laridae Orden: Falconiformes Familia: Falconidae Orden: Gruiformes Familia: Rallidae Orden: Gruiformes Familia: Rallidae Orden: Gruiformes Familia: Rallidae Orden: Gruiformes Familia: Rallidae Orden: Charadriiformes Familia: Scolopacidae Orden: Charadriiformes Familia: Scolopacidae Orden: Passeriformes Familia: Furnariidae Orden: Passeriformes Familia: Icteridae Orden: Passeriformes Familia: Thraupidae Orden: Passeriformes Familia: Tyrannidae Orden: Passeriformes Familia: Hirundinidae Orden: Pelecaniformes Familia: Ardeidae Orden: Pelecaniformes Familia: Ardeidae Orden: Pelecaniformes Familia: Pelecanidae Orden: Podicipediformes Familia: Podicipedidae Orden: Strigiformes Familia: Strigidae Orden: Pelecaniformes Familia: Ardeidae Orden: Pelecaniformes Familia: Ardeidae Orden: Pelecaniformes Familia: Ardeidae Orden: Pelecaniformes Familia: Ardeidae Orden: Anseriformes Familia: Anatidae Orden: Anseriformes Familia: Anatidae Orden: Cathartiformes Familia: Cathartidae Orden: Cathartiformes Familia: Cathartidae Orden: Apodiformes Familia: Trochilidae Orden: Anseriformes Familia: Anatidae Orden Orden: Myrtales Familia: Onagraceae Duraznillo de agua Ludwigia peploides Flor del pato Azolla filiculoides Araña bandeada Argiope trifasciata Hormigón dorado Camponotus chilensis Orden: Didelphimorphia Familia: Didelphidae Yaca común Thylamys elegans Avispa cazadora de arañas Entypus unifasciatus Orden: Orthoptera Familia: Acrididae Saltamontes Dichroplus elongatus Orden: Araneae Familia: Araneidae Araña verde Molinaranea magellanica Camarón de río del norte Cryphiops caementarius Orden: Diptera Familia: Culicidae Mosquito charquero o Zancudo Aedes albifasciatus Mosca de alas pintadas Pterotaenia fasciata Orden: Caryophyllales Familia: Amaranthaceae Sosa Salicornia neei Batro o Trome Schoenoplectus californicus Junquillo o Junco espinoso Juncus acutus Totora Typha angustifolia Roseta de los pantanos Goodenia radicans Hierba de la plata Hydrocotyle ranunculoides Chorlo de collar Anarhync


An Imaging Search for Circumstellar Companions of Sirius B Miles Lucas1, Michael Bottom1, Garreth Ruane2, Sam Ragland3 Why study Sirius B? • Little is known about planetary systems around evolved hosts; we are interested in looking for second-generation companions that form or migrate after the violent RGB and AGB phases • Sirius B is close, which lets us probe sub-AU regions without coronagraphy. It is relatively dim from white dwarf cooling, decreasing the contrast required to image a giant planet. Lastly, it is young (225 Myr), which means giant planets will still be bright from their latent formation heat. • Sirius B is well-characterized: especially its mass, age, and astrometry- reducing uncertainties of companion properties Observations • We took direct images over three epochs in 2020 using Keck/NIRC2 in L’-band (3.776 µm) and narrow FOV (10”x10”) • Sirius A is so bright that diffraction was present in the Sirius B FOV, stalling the AO loop and ruining the coronagraphic pointing algorithm (QACITS) • We were able to close the AO loop by targeting Sirius A using a narrow (~10 nm) laser-line filter in front of the WFS to avoid saturation. We then guided off-axis to Sirius B • We set the field rotator to track the pupil, enabling angular differential imaging (ADI) 0 200 400 x 0 100 200 300 400 500 y 1500 1000 500 0 500 1000 1500 1500 1000 500 0 500 1000 1500 spider diffraction spike from Sirius A 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 projected separation [AU] 2 4 6 8 10 12 14 companion mass [MJ] mean uncertainty from age dynamical stability limit 0.1 0.2 0.3 0.4 0.5 0.6 0.7 separation [arcsec] 2020-02-04 2020-11-21 2020-11-28 model mass limit 0.1 0.2 0.3 0.4 0.5 0.6 0.7 separation [arcsec] Sensitivity Analysis ADI Analysis -2.0 -1.0 0.0 1.0 2.0 -2.0 -1.0 0.0 1.0 2.0 y [AU] median Epoch 2020-02-04 -2.0 -1.0 0.0 1.0 2.0 x [AU] median Epoch 2020-11-21 -2.0 -1.0 0.0 1.0 2.0 annular PCA(2) Epoch 2020-11-28 Results & Discussion • Consistent with previous results, we do not detect any companions around Sirius B • We improve on the sensitivity limits of Sirius B by reaching an average sensitivity of ~2 MJ in the speckle-limited regime (< 1 AU) down to 0.4 MJ in the background-limited regime (> 1 AU). • These sensitivities are the deepest and closest, yet, and only have ~0.1 MJ uncertainty due to Sirius B’s precise age • Future space-based observations can improve the mass sensitivities (if the challenges presented by Sirius A can be overcome), but would be limited by current planetary grid models Acknowledgements The data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. The authors wish to recognize and acknowledge the very significant cultural role and reverence that the summit of Maunakea has always had within the indigenous Hawaiian community. We are most fortunate to have the opportunity to conduct observations from this mountain. 1. Repeatedly inject fake companions at different seperations with a fixed S/N (100) 2. Reduce the injected cube for each ADI algorithm and measure the S/N of the companion in the residual frame 3. Compute the 5σ detection limit in terms of contrast. Dashed curves correct for small-sample statistics 4. Convert the contrast curves to planetary masses using grid models (AMES/COND) 1. Pre-process data with typical ADI workflow: calibration, co-registration, cropping, and parallactic angle calculation 2. Using the following ADI algorithms (median, PCA, NMF, GreeDS), model the stellar PSF and subtract it from the data 3. Derotate and collapse the residual cube using a weighted sum 4. Calculate detection probability using S/N and STIM map; calculate sensitivity using contrast curves 5. Residuals from the best algorithm for each ep


Counting analysis of Borexino Phase-III data for the detection of CNO solar neutrinos Riccardo Biondi on behalf of Borexino Collaboration 1Laboratori Nazionali del Gran Sasso Abstract An accurate measurement of the Solar Neutrino Flux from CNO cycle can shed light on the so called “solar abundance problem“: new determinations of the photospheric abundances of heavy elements indicates that the Sun metallicity is lower than previously assumed, however Solar Models incorporating lower abundances are no more able to reproduce the helioseismic results. We propose a method for detecting the CNO interaction in the Borexino detector from a counting analysis in a Region of Interest determined maximizing a Figure of Merit and using both analytical and Monte Carlo modeling of the detector response. In such a way we can keep under control all systematics and avoid unwanted sources of uncertainties. The procedure itself is inspired by a CNO sensitivity[1] study pointing out that the sensitivity to CNO is basically given by the knowledge of the background from Bi210 and pep neutrinos, being the other backgrounds negligible or constrainable. Mini-abstract: CNO interaction rate in the Borexino detector from counting analysis Poster Id: 93 Contact: riccardo.biondi@lngs.infn.it Motivation and Strategy We want to use counting analysis to determine CNO neutrinos interac- tion rate in Borex- ino detector[2]. Muon PMTs Stainless Steel Sphere Internal PMTs Water Tank Nylon Vessels Scintillator Non-scintillating Buffer Motivation: Complementary to a full spectral study[3] without the uncertainty of background and de- tector response modeling. Systematics can be reliably evaluated. This method could give high sensitivity[1]. Strategy: Choose an energy Region of Interest (ROI) where the expected discovery signiﬁcance of CNO neutrinos is maximized(Figure of Merit). Count the events in ROI Subtract all identiﬁed background events Proﬁle parameters to estimate uncertainties Results obtained with analytical response of the de- tector and Number of Photo-Electrons (Npe) as en- ergy estimator will be shown in this poster. Figure of Merit Figure of Merit is deﬁned as: F = NCNO σCNO (Sys.⊕Stat.) Major contributions of systematics comes from 210Bi and detector response parameters such as 11C quenching and Light Yeld 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 Tot σ / iσ Relative contribution of Systematics Bi 210 C Qch 11 LY C 11 (pep) ν Be) 7( ν Others Relative contribution of Systematics 200 250 300 350 400 450 500 550 600 min Npe 200 250 300 350 400 450 500 550 600 max Npe 0 1 2 3 4 5 Figure of Merit 200 300 400 500 600 700 800 900 1000 Npe 1 − 10 1 10 2 10 3 10 4 10 events / Npe Data (CNO) ν Bi 210 (pep) ν C 11 Be) 7 ( ν Others Selected Energy Range Optimum Range: [375 - 429] Npe Region of Interest Species (Si) Events Fraction N 823 ± 28.7 210Bi 261.5 ± 29.6 0.31 ν(pep) 171.7 ± 2.4 0.21 ν(7Be) 86.8 ± 2.6 0.10 11C 57.9 ± 5.8 0.07 Others 15.6 ± 1.6 0.02 P i Si 593.5 ± 30.4 0.71 In the selected ROI we have a total of 823 ± 28.7 events. The expected values and errors on number of events for each species is calculated according to bounds coming from independent studies[4][5][6] and using a reference response model of the Detector. If we subract the sum of the species Si from the to- tal N we are left with the sought after signal: NCNO = N −P i Si = 229.5 ± 41.8 events Systematics Systematics are obtained as the width of the distri- bution of CNO rate after varying parameters on 104 Toy-MC realizations where we determine the num- ber of CNO events subtracting all the other species from the total events in the ROI. Parameters are varied according to: 210Bi: independent determination[4]. ν(pep) Luminosity constraint [5]. ν(7Be) rate according to Solar Models[6]. Light Yeld: generated according to its correla- tion with ν(7Be) rate, adding a 0.7 % smearing. All the other species and detector response parame- ters are varied in a conservative way with respect to the reference


William Kent:The Many Forms of a Single Fact* Data sharing and integration properties A simple fact Example of a simple fact: Certain salesmen serve certain territories. Some data design options Why the "many forms" of solutions matters Representations of data items Interpretations of Transformations between structural organizations Different data types Field lengths Units of measure Precision Etc. Meaning of some terms Measurement qualities Reconciliation of quantities Relational, hierarchical, & network models Various file formats Implementations of lists, vectors, arrays, object models, etc. A simple connection between two things A relationship or an attribute A semantic web assertion Does NOT always map onto a pair of fields Each salesman has one territory Each territory has one salesman Many salesmen in many territories: many-to-many Many-to-few Usually many-to-one Salesmen without territories Several connections Data interchange: accommodate variations in semantics Data documentation (dictionaries): facts in a database do not always correspond to data elements in simple and direct ways Data design competence Design tools and methods: number of options large; heuristics and expert system support needed Data sharing by new apps Redundancy management Data integration High-level queries: distributed data: heterogeneity can exist between databases containing the same information in the same type of data structure Entity-relationship theory: data design choices need to be based on data processing concerns Conceptual schema: a logical data model is not a data-independent model of the enterprise Kent, W. "The Many Forms of a Single Fact", IEEE Compcon, 1989, DOI: 10.1109/CMPCON.1989.301972 W.L. Anderson, 2013, CC-BY


Lea Sophie Singson (FIZ Karlsruhe); Constantin Breß (FIZ Karlsruhe) Don‘t be scared of the big bad wolf: a call to improve licensing landscapes in agro science repositories The need: Science loves open data. But science also loves to be attributed. How do we ﬁx this? We license our work! A call to action: We have two options: ●Use dedicated data licenses with attribution, e.g. Datenlizenz Deutschland. Caveat: Depends on access and is relative ●Trust the GWP. Binding use of the GWP is spreading in research institutions and includes attribution Repositories should take a leading role and inform users The FAIRagro DSSC can provide support (https://fairagro.net/helpdesk/) The practise: On the hunt for the perfect attribution mark, we found the CreativeCommons licenses. And they seem perfect! They are well known, easily understandable and they do exactly what I need. But do they? The Problem: The CreativeCommons are licenses speciﬁcally created to license copyright protected work. This is a discrepancy with the scientiﬁc data mostly published in agricultural science! To be protected under copyright, a work has to reach a threshold of originality -> the effect of using CC-licenses incorrectly What is a threshold of originality? -> a certain reﬂection of the authors personal touch -> the work must not only consist of content and structure deﬁned by the speciﬁc domain Using CC-Licenses incorrectly: no security for creator to be cited; creates legal uncertainty regarding the validity of the CC-License


The Metallicity-Inclination Relation: Higher Metallicity, Higher Mutual Inclination Xinyan Hua (huaxinyan1996@gmail.com), Sharon Xuesong Wang, Songhu Wang, Dongsheng An, Wei Zhu, Fei Dai, Dichang Chen, Jiwei Xie vAbstract vSample Selection Ø Kepler & K2 samples from Dai et al. 2018 Ø TESS samples from this work Innermost 2 planets R < 4 [Earth Radii] + Innermost planet a/Rs < 12 vMain Results Ø A postive trend with metallicity: Higher matallicity, higher mutual inclination Ø Not significant with mass vDiscussion Ø Unlikely to be caused by USPs Ø Metal-rich systems tend to be dynamically hotter REFERENCES: Dai, F., Masuda, K., & Winn, J. N. 2018, ApJL, 864, L38, doi: 10.3847/2041-8213/aadd4f Brewer, J. M., Wang, S., Fischer, D. A., & Foreman-Mackey, D. 2018, ApJL, 867, L3, doi: 10.3847/2041-8213/aae71 Ø Need more followups to constrain giants Winn, J. N., Sanchis-Ojeda, R., Rogers, L., et al. 2017, AJ, 154, 60, doi: 10.3847/1538-3881/aa7b7c Ultra-short-period planets [Fe/H] ∆𝑖 Winn+ 2017 Dai+ 2018 This Work Stellar metallicity is very often found to correlate strongly with occurrence of certain types of planets or planetary system properties. For instance, Jupiter analogs are more common around metal-rich stars, while compact multis tend to be metal- poor. In this study, we present a correlation between the stellar metallicities and the mutual inclinations of multi-planet systems, suggesting that metal rich stars host planetary systems that are dynamically hotter. After investigating ~100 targets with measured mutual inclinations from photometry analysis, we observed that planets orbiting metal-rich stars tend to exhibit more dispersed mutual inclinations. Moreover, there is no clear evidence linking the high mutual inclination of these inner small planets with the existence of outer gas giants, though more data are needed to draw any definitive conclusion. We also observed a similar trend in the stellar mass - mutual inclination space, which is not as significant as with stellar matellicity. We hypothesize that such systems accumulate more material within their proto-planetary disks, leading to a more intensive dynamical evolution process that can perturb the planets into misaligned orbits, resulting in higher mutual inclinations. Planet formation and population synthesis models tracking evolution of mutual inclinations would be needed to provide explanation for this correlation.


The ALMA Program Management Group (PMG) is responsible for the day-to-day management of observation execution, tracking of the status of ALMA programs, data quality control, and coordination of these activities with staff at the three ALMA Regional Centers (ARCs). It consists of a Program Manager and eight Data Analyst, with the support of about thirty Astronomer on Duties (AoD) to carry out the ALMA observation executions, in service mode, at the ALMA Control rooms at the Operations Support Facility (OSF) and Santiago Central Offices (SCO). Here, we present the mission, core operational tasks, deliverables, and activities of the ALMA Program Management Group, as well as, a description of the entire ALMA Data Acquisition Process, and its last cycles performance based in the ALMA Key Performance Indicators (KPI). The ALMA Program Management Group and the ALMA Data Acquisition Process Juan R. Cortés1,2, Matías Radiszcz1, Celia Verdugo1, Cristián López1, Gabriel Marinello1, Jorge Morgado1, Priscilla Nowajewski1 & Kurt Plarre1. 1Joint ALMA Observatory, Santiago Central Offices, Alonso de Córdova 3107, Vitacura, Santiago, Chile 2National Radio Astronomy Observatory, Alonso de Córdova 2860, of. 702, Vitacura, Santiago, Chile Contact E-mail: juan.cortes@alma.cl Program Management Group Mission The ALMA Program Management Group (PMG) has the following Mission: To carry out Efficient and Effective, ALMA program management and quality assured data Acquisition. i.e. its responsibilities are –ALMA Program Management: • Tracking of ALMA programs. To know exactly what is the status of every ALMA Project, and SchedBlock (SB). • Ensure that Projects/SBs must be in the right status. SBs shouldn’t get stuck for any reason in data acquisition workflow. –Data acquisition: • Take the best possible data (effectiveness, QA0) • Making the best use of ALMA Observing time (Efficiency) • Ensure data acquisition –Antenna readiness for Science. –Data calibrations: Calibration Surveys, etc. PMG Operational Tasks Core Deliverables What PMG delivers: –Full Deliverables: »Calibratable Fully Observed MOUS/SBs »QA0 Pass EBs »Suitable calibrators candidates (BP, Phase, Flux, Check Sources, TP-off) »Key data for data processing: Calibration sources flux ingestion, Antenna Position. »Complete follow up of Data Acquisition workflow. »Reports on completion of Projects SB »Data Acquisition Metrics and KPI »Tools that allows accurate tracking of projects, SBs. »Management and Coordination of Data Acquisition activities. –Partial Deliverables: Calibratable Observing Timed Out MOUS/SBs. ALMA Data Acquisition Process ALMA Data taking and Reduction Processes can be divided in four stages: • Data Request: PI proposal approval and Phase 2 preparation (SBs) • Data Acquisition: Data taking itself. • Data Processing: Data reduction and analysis. • Data Delivery: Archive Ingestion and Delivery to PI Data Acquisition Metrics and KPIs Data Acquisition Workflow Fig. 4. Data Acquisition Workflow. Data acquisition starts with SB Generation by P2G. Antenna array are prepared and calibrated (Delay, and Focus). SB is observed using the Dynamical Scheduling Algorithm based on raking, observing conditions, etc. Execution is quality assured and once the SBs reach required rms is declared Fully Observed and goes to data processing. In parallel, calibration observations are done (Cal. Survey, TP-off, Cone-searches), and antennas are integrated to the array. Cycle 9 Performance Contact Information Fig. 5. Accumulated QA0 Pass time. Upper panel: 12m-Array. Data acquisition affected by Cyberattack. We reached 3362 hours. Lower panel: 7m-Array. We reached 3466 hours, almost all our allocated observations. TP-array (not shown) reached 2369 hours, a record in ALMA history for TP array. PMG Level 1 KPIs. • Operations Efficiency (target ≥ 90%): 88% • Remaining Time (≤ 290 hours): 281 hours. • QA0 failures + QA0 semi-pass time (≤ 200 hours). 233 hours. Fig 1. PMG Core Operational Tasks. These are th


Development projects: complex endeavors, that not only re- quire the coordination of a multitude of stakeholders, but the continued support by key decision-makers. Research gap: present project management frameworks tend to disregard the role end-users can play in the project implemen- tation phases, relegating their impact on project success primari- ly to the adoption of project outputs. Research question: Cape Verde, an insular African nation located in the Atlantic Ocean, as a climatic pattern off prolonged dry seasons with very brief monsoons. Water scarcity is a major limiting factor of food production, and dramatically conditions food security. In 2010 the government launched a ten year plan, calling for the construction of irrigation reservoirs. One these reservoirs was the Figueira Gorda reservoir, which although completed in 2014 the irrigation network was never built. Project success can be a contentious issue (Ika & Pinto, 2022), however, regardless of the specific success criteria, the absence of an irrigation network renders the Figueira Gorda a failure. Despite the project's top-down abandonment, local small farm- ers, the end-users, creatively utilized the water made availa- ble by the reservoir within their water-constrained environment to cultivate irrigated crops. We applied an abductive research design (Sætre & Van De Ven, 2024), starting with an exploratory case study analysis (Yin, 1994), focusing on the Figueira Gorda due to its extreme nature (Flyvbjerg, 2006), characterized by a distinct top-down abandon- ment of the project, juxtaposed with evident end-user-driven pro- ject success. Utilizing an inductive qualitative approach, we triangulated findings from various data sources (Denzin & Lincoln, 2018), in- cluding farmer surveys, subject-matter expert interviews, pub- licly available news, and satellite imagery. We sincerely thank Luís Brites Pereira of Nova School of Business and Economics, Miguel Lino Ferreira of the Graduate School of Business at the University of Cape Town, and Arlindo Fortes of the Universidade de Cabo Verde for their support and guidance throughout this project. Their insights and inputs have been invaluable in shaping this research. Bricolage, defined as 'making do by applying resources at hand to new problems' (Busch & Barkema, 2021, p. 741), encap- sulates the actions of small-farmers at the Figueira Gorda reser- voir. Following the project's construction, and despite its failure, the small-farmers became bricoleurs, ingeniously utilizing the limiting resource just made available. Our study demonstrates that when failed or abandoned pro- jects offers access to the limiting resource, end-users can de- velop a bricolage repertoire to extract value from it, fostering a virtuous cycle that leads to project success. Busch, C., & Barkema, H. (2021). From necessity to opportunity: Scaling bricolage across resource- constrained environments. Strategic Management Journal, 42(4), 741-773. doi.org/10.1002/ smj.3237 Denzin, N., & Lincoln Y. (2018). The SAGE Handbook of Qualitative Research (6th ed.). SAGE Publica- tions, Inc Flyvbjerg, B. (2006). Five misunderstandings about case-study research. Qualitative Inquiry, 12(2), 219-245. doi.org/10.1177/1077800405284363 Ika, L. A., & Pinto, J. K. (2022). The “re-meaning” of project success: Updating and recalibrating for a modern project management. International Journal of Project Management, 40(7), 835-848. doi.org/10.1016/j.ijproman.2022.08.001 Sætre, A. S., & Van De Ven, A. (2024). Abductive Theorizing Is More Than Idea Generation: Disciplined Imagination and a Prepared Mind. Academy of Management Review, amr.2021.0317. https:// doi.org/10.5465/amr.2021.0317 Yin, R. K. (1994). Discovering the future of the case study. Method in evaluation research. American Journal of Evaluation, 15(3), 283-290. https://doi.org/10.1177/109821409401500309 Cape VerdeSantiago IslandFigueira Gorda reservoirPhD thesis tutor:María Concepción López-Fernández Univ


AÑOS (OBRAS) MÁS FRECUENTES EN LA HISTORIOGRAFÍA LINGÜÍSTICA HISPÁNICA 1492 1771 1847 1726 1555 1870 1495 FUENTE: "BiTe_Corpus" Battaner, Elena & Herranz, Cristina & Segovia, Ana (2022). "BiTe_Corpus" (Version 01) [Data set]. doi.org/10.5281/zenodo.6828326) Elena Battaner Moro, Universidad Rey Juan Carlos (@BattanerElena) I Congreso Iberoamericano de Ciencia abierta 2022 Gramática castellana Antonio de Nebrija Gramática de la lengua castellana compuesta por la Real Academia Española (Primera GRAE) Gramática de la lengua castellana, destinada al uso de los americanos Andrés Bello Diccionario de la lengua castellana, en que se explica el verdadero sentido de las voces [...] (Diccionario de Autoridades) Vtil y breve institution para aprender los principios y fundamentos de la lengua hespañola. = [...] (Anónimo de Lovaina) Gramática de la lengua castellana por la Academia Española (12.ª ed. de la GRAE) Introductiones latinae Antonio de Nebrija, Recognitio


Background The Visual Question Answering (VQA) task consists on having a model that, given an image and a natural language question about the image, can provide an accurate natural language answer [1]. In the medical domain, VQA systems from the general domain have been adapted. However, because the nature of medical images differs from general images, some techniques like object detection cannot be easily adapted. Furthermore, the type of questions that can be asked about medical images is different too. This work in progress addresses the question of how can VQA systems and corresponding datasets be built, that deal with questions about speciﬁc regions of an image. This includes possible questions about the contents of a single region, as well as about two different regions of an image. 1 Dataset Models As a baseline, the model shown in Figure 2 was implemented. In this model, the mask is applied to the image in order to isolate the region about which the question is asked. Alternative models with different ways of including the region mask are implemented as well. These include for example applying the mask to the attention maps, or fusing it directly in the multimodal fusion step. Preliminary Results Tests have been carried out in order to establish the best way to include the information about the region into the VQA. These preliminary tests show that applying the mask to the image brings the best performance, which suggests that contextual information is actually not needed in order to answer questions about the inside of a region. Figure 3 shows the corresponding precision-recall and ROC curves of the baseline model. Current and future work includes the creation of a similar dataset for general images, as well as asking questions about multiple non-overlapping regions. References [1] Agrawal, A., Lu, J., Antol, S., Mitchell, M., Zitnick, C.L., Batra, D., & Parikh, D. (2015). VQA: Visual Question Answering. In Proceedings of the IEEE International Conference on Computer Vision (pp. 2425-2433). [2] Prasanna Porwal, Samiksha Pachade, Ravi Kamble, Manesh Kokare, Girish Deshmukh, Vivek Sahasrabuddhe, Fabrice Meriaudeau. (2018). Indian Diabetic Retinopathy Image Dataset (IDRiD). IEEE Dataport. https://dx.doi.org/10.21227/H25W98. 3 AIMI Lab AIMI Lab, ARTORG Center, University of Bern sergio.tasconmorales@artorg.unibe.ch Sergio Tascon-Morales , Pablo Márquez-Neila, Raphael Sznitman Building a VQA dataset that contains questions about regions of an image is a challenging task because of the lack of annotated data and also because of the complex task of deﬁning the questions that could be asked. Another important factor to consider is the data imbalance. As basis for building a region-based VQA dataset we use the Indian Diabetic Retinopathy Image Dataset (IDRiD) which contains a total of 81 fundus images with corresponding segmentations for 4 different biomarkers: microaneurysms, soft and hard exudates, and hemorrhages. Annotations for the optic disc are also available. For each image-biomarker pair, a total of 100 random regions were generated with questions about the presence of the biomarker in the region (Figure 1). Figure 3. Preliminary precision-recall and ROC curves for the region-based dataset. Figure 2. Simpliﬁed baseline model with multi-glimpse attention mechanism (left) and attention mechanism structure (right). Figure 1. Examples of questions in the region-based dataset. Q: Is the optic dist in this region? A: Yes Q: Are there hard exudates in this region? A: No Visual features Question features fusion Classiﬁer Question Answer ResNet152 LSTM Conv 2d 1x1 Linear Expand ReLU Conv 2d 1x1 fusion Hadamard Softmax dim -1 Image Mask (1, 448, 448) X Attention mechanism Apply attention Question features Visual features Attention maps


Aim 2: Track changes in phageomes and bacteriomes of captive mice after tranpantation of wild phageomes. Čížková D. 1, Payne P. 1,2, Bryjová A. 1, Ďureje Ľ. 1, Piálek J. 1, Kreisinger J. 2 1 - Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno, Czech Republic 2 - Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic Gut bacteriomes have profound effects on their vertberate superhosts. Bacteriophages are key regulators of bacterial communties. Aim 1: Comparison of gut phageomes and bacteriomes between wild and captive mice. Study design: House mouse - Mus musculus musculus • 10 wild mice from 3 localities (Jedov, Naloucany, Velke Pole) • 26 captive mice from 2 wild-drived strains (BULS and BUSNA) Phageome transplantation - caecal filtrates Bacteriome monitoring - 16S rRNA metabarcoding from feces Phageome monitoring - Whole metagenome sequencing of fecal filtrates PCoA - phage contigs Wild and Captive Phageomes are different: Cluster heat map - abundant phage contigs Phageomes Mirror Bacteriomes: Procrustes - correlation in bacteriome and phageome Changes in the Contig level phageome distances between recipents and donors Phageome of captive recipents converge to wild donors: Changes in the Sub-Contig level phageome distances (SNPs in shared contigs) BUSNA phageomes converge to wild donors at the Contig level distances. BULS phageomes converge to wild donors at the Sub-contig level distances. BUSNA BUSNA BULS BULS day x treatment: p = 0.225 day x treatment: p = 0.070 day x treatment: p = 0.250 day x treatment: p = 0.480 day of experiment day of experiment day of experiment day of experiment Changes in the ASV level bacteriome distances between recipents and donors No effect of phageome transplantation on bacteriome: Gut phageome differed between wild and captive house mouse. Phageome transplantation resulted in transfer of wild phages to captive phageomes, but without major changes in phageome structure. Transferred phages differed between the two recipient mouse strains. Phage transfer did not induce any measurable effects on the gut bacteriome. This has implications for safety of medical phage transplants. This research has been supported by the Ministry of Education, Youth and Sports of the Czech Republic grant Talking microbes - understanding microbial interactions within One Health framework (CZ.02.01.01/00/22_008/0004597).


POSTER PRESENTATION Open Access SpineML and Brian 2.0 interfaces for using GPU enhanced Neuronal Networks (GeNN) Thomas Nowotny1*, Alexander J Cope2, Esin Yavuz1, Marcel Stimberg3, Dan FM Goodman4, James Marshall2, Kevin Gurney5 From The Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014 Background The GPU enhanced Neuronal Networks (GeNN) frame- work [1,2] was introduced in 2011 to facilitate the efficient use of graphical processing units (GPUs) as accelerators for neuronal network simulations, in particular as part of computational neuroscience investigations. GeNN is based substantially on code generation for the NVIDIA CUDA application programming interface. Code generation pro- vides decisive advantages over stand-alone simulators in that (i) code can be optimized both for every individual model and for the specific GPU hardware detected at compile time, and (ii) code generation allows to provide a practically limitless number of pre-defined models while the generated simulation code remains as small and effi- cient as possible. While GeNN is an important step towards facilitating the use of GPU acceleration for computational neu- roscience applications it has been designed with expert users in mind. Particular emphasis has been put on flex- ibility and extendibility and, in case of conflict, these were prioritized over the easy of use. In the work presented here we are aiming to make GeNN and the corresponding GPU acceleration now also available to non-expert users by providing two new inter- faces from SpineCreator [3]/SpineML [4] and the Brian 2 simulator [5,6] to GeNN. Results We have created prototype interfaces from SpineCreator using the SpineML markup language and from Brian 2 by modifying the code generation facilities within Brian 2 to generate valid GeNN input files. In both cases, a middleware was created that takes the model descrip- tions that were either available in SpineML (as gener- ated by SpineCreator) or the internal representation in Brian 2 and translate them into the three main code parts necessary to run a GeNN simulation: (i) Neuron, synapse and network definitions including variables, parameters, code to integrate dynamical equations and properties of the connectivity, (ii) Code that runs the GeNN generated code to execute the simulation and (iii) code that regulates the transfer of information from SpineCreator/Brian 2 to GeNN and vice versa (e.g. for providing connectivity matrices and returning simula- tion results). Conclusions We believe that when the new SpineCreator and Brian 2 interfaces will have been fully developed, tested and released we can make a decisive difference in the uptake of GPU acceleration for neuronal network simulations. The completed prototypes show sufficient flexibility and ease of use to be appealing to a wide range of future users. Acknowledgements This work was supported by the EPSRC (Green Brain Project, grant numbers EP/J019690/1, EP/J019534/1 and Delivery Plan ‘Kickstart’ funding). Authors’ details 1CCNR, School of Engineering and Informatics, University of Sussex, Falmer, Brighton BN1 9QJ, UK. 2Department of Computer Science, University of Sheffield, Sheffield S1 4DP, UK. 3Institut d’Etudes de la Cognition, Ecole Normale Supérieure, Paris, France. 4Harvard Medical School, Harvard University, Boston, MA 02115, USA. 5Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK. Published: 21 July 2014 References 1. Nowotny T: Flexible neuronal network simulation framework using code generation for NVIDIA CUDA. BMC Neurosci 2011, 12(Suppl 1):P239. * Correspondence: t.nowotny@sussex.ac.uk 1CCNR, School of Engineering and Informatics, University of Sussex, Falmer, Brighton BN1 9QJ, UK Full list of author information is available at the end of the article Nowotny et al. BMC Neuroscience 2014, 15(Suppl 1):P148 http://www.biomedcentral.com/1471-2202/15/S1/P148 © 2014 Nowotny et al; licensee BioMed Central


Positionality, reflexivity and ethics in global public health research Chloe Tuck1, Isaac Boadu2, Laura Gray1, Robert Akparibo1,3, Richmond Aryeetey2, and Richard Cooper1 School of Health and Related Research, University of Sheffield, UK. 2. University of Ghana, Accra, Ghana. 3. University of Health and Allied Sciences, Ho. Correspondence to: Chloe Tuck cztuck1@sheffield.ac.uk Herein we aim to critically reflect on levels of discordance to foster more ethical and collaborative research. Reflexivity and positionality were applied to better understand the role of the researcher, their social experiences, position and power hierarchies influence knowledge generation. This involved sharing researchers’ experience following an exchange between the University of Ghana and the University of Sheffield, fostering a collaboration with a teaching hospital in northern Ghana for mixed methods data collection and analysis, discussion and reviewing relevant literature from Health Sciences, Geography and Sociological sciences. “Please use your liberty to promote ours” Aung San Suu Kyi, Feb 19979 “colonisation gave the world… a particular way of looking (or, rather, not looking) at Africa that endures, alas, into our own day” Chinua Achebe, 1998: page 20, In Africa’s Tarnished Name1 Funded by [108903/B/15/Z] We would like to acknowledge the ongoing support of all collaborators in this work at Tamale Teaching Hospital and the University of Ghana. Writings by Achebe in 1998 do not cease to have pertinence today. As global public health researchers, we strive to increase health system efficiency and reduce inequity due to factors associated with healthcare access and societal wellbeing. Many of the areas of greatest health need are in low-income contexts whilst funding and decision making remain tied to high-income settings. Poorly considered research across settings can create disconnect between the researcher and research, further instils colonialist attitudes, and enforces power hierarchies. Background Visual summary of findings Methods References can be found here: We also invite feedback on our approach to: cztuck1@sheffield.ac.uk Conclusions “the Bantu declaration 'Umuntu ngumuntu ngabantu' represents an African communal aspiration: 'A human is a human because of other humans'. Our humanity is contingent on the humanity of our fellows.” Chinua Achebe, 1999 Africa Is People.8 Reflexivity and positionality are vital to consider for ethical global health research. This further Achebe quote reminds us our communality, our becoming through cooperation and relationships to each other. To construct collaborative approaches, we need to actively challenge colonial imperatives that have dominated western thought and to which we are often blind. Where we have liberties, use it to promote others.


High-dose busulfan (BU) is the cornerstone of conditioning regimens prior to HSCT in children. The relation of BU exposure and event-free survival (EFS) is not clear due to conflicting reports especially in pediatric patients The cum AUC (mg × h/L ) exposure targets for BU were : EMA: 59–99 ; US-FDA: 59–89 Bartelink IH et al. 1: 78-101 mg × h/L Better EFS with cumAUC of <57.6 or between 57.6 - 67.2 mg × h/L1,2,3 cumAUC of 86.4 mg × h/L showed better EFS, in pediatric patients4 All these studies were evaluated retrospectively with a sample size varying from 45 to <100 patients. No clear consensus among peers about the utility of BU cumAUC as an indicator of EFS Is there any other dynamic indicator/marker of BU efficacy ? Background References 1. Bartelink et al., Lancet Haematol. 2016; 3: e526-e536 2. Ansari et al., Ther Drug Monit 2014;36:93-99 3. Baker et al., Bone Marrow Transplant 2000; 26,:607–614 3. 4. Maheswari et al., Bone Marrow Transplantation 2014: 49, 366–369. 5. McCune et al., Bone Marrow Transplant. 2002;30(3):167-73. Results Methods Conclusion The BU MR (BU/SU) on day 3 above 4.973 and 25.06 were associated with worse EFS in children undergoing HSCT and received BU in QID and QD dosing schedules, respectively. Predictive nature of MRs measured were replicated in two different BU dosing schedules followed. These observations deserve attention and need to be replicated in a larger study, especially in an external cohort to rule out any unidentified bias in this analysis. 44 received BU four times daily (QID) and 13 received BU once daily (QD; (n=13; 10 allogeneic HSCTs and 3 autologous HSCT). BU/SU = MR was measured on the 3rd day of conditioning. EFS was defined from the time of transplant until death, relapse, or rejection, whichever occurred first. Chakradhara Rao S Uppugunduri1,2, Aziz Rezgui3, Patricia Huezo-Diaz Curtis1,2, Tiago Nava1,2, Simona Mlakar1,2, Yves Theoret4, Henrique Bittencourt5, Maja Krajinovic3, Marc Ansari1,2 Busulfan/Sulfolane metabolic ratio on the third day of conditioning may predict the event-free survival in children receiving busulfan based conditioning prior to hematopoietic stem-cell transplantation Huezo‐diaz P & Uppugunduri CRS et al., CDM, 2014; 15:251‐264 Objective: To evaluate the utility of BU MR (busulfan/sulfoalne,SU) to predict event-free survival (EFS) in children undergoing HSCT, retrospectively. Four times daily BU (n=44) Events occured No Events N (%) N(%) Gender Male 7 (31.8) 15 (68.2) Female 10 (45.5) 12 (55.5) Diagnosis (S) Malignancies (ALL, AML, MDS) 16 (59.3) 11 (40.7) Non‐ malignancies (/HP, ID, Met Dis,) 1 (5.9) 16 (94.1) Disease Status (Leukemia) (T) CR1 6 (60) 4 (40) CR2 / CR3 / Relapse 4 (80) 1 (20) HLA compatibility MUD 3 (57.1) 4 (42.9) MRD 3 (21.4) 11(78.6) MM RD 2 (66.7) 1 (33.3) MM UD 9 (45) 11 (55) Stem Cell Source BM 5 (27.8) 13 (72.2) Cord Blood 12 (46.2) 14 (53.8) Conditioning Bu/Cy 16 (39) 25 (61) Bu/Cy/VP16 1 (50) 1 (50) Bu/Mel 0 1 (100) Serotherapy ATG 13 (37.1) 22 (62.9) None 4 (44.4) 5 (55.6) Mean (SD) Mean (SD) Age (years) 8.9 (4.9) 6.2 (5.94) Weight (Kg) 35.1 (20.9) 22.7 (18.5) Once daily BU (n=13) Events occured No Events N N Gender Male 1 3 Female 6 3 Diagnosis (S) Malignancies (ALL, AML, MDS) 6 2 Non‐malignancies (/HP, ID, Met Dis,) 1 4 Disease Status (Leukemia) (T) CR1 3 0 CR2 / CR3 / Relapse 2 0 Partial Remission 1 1 HLA compatibility MUD 1 0 MRD 1 5 MM RD ‐ ‐ MM UD 3 0 Stem Cell Source BM 1 3 Cord Blood 4 2 PBSC (AUT) 2 1 Conditioning Bu/Cy 2 3 Bu/Flu 3 2 Bu/Mel 2 1 serotherapy ATG 3 4 None 4 2 Mean (SD) Mean (SD) Age (years) 6.1 (5.6) 7.4 (4.7) Weight (Kg) 17.4 (2.6) 17.0 (1.4) 1University Hospitals of Geneva, Onco‐Hematology Unit, Department of Pediatrics, Geneva, Switzerland, 2CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 3Charles‐Bruneau Cancer Center, CHU Sainte‐Justine Research Center, Montreal, Canada, 4Charles‐Bruneau Cancer Center, Department of Pharmacology and Physiol


Innovative Research for a Sustainable Future www.epa.gov/research m/z 455.2897, 6.70 min 0.1 1 Verapamil (Parent Drug) Normalized Abundance Tyler S. Larson l larson.tyler@epa.gov l 434-942-5470 Untargeted LC-MS/MS Analysis of Drug Metabolites in Human Hepatocyte Suspensions for Comparison to Liver S9 Fractions Tyler S. Larson1, Krishna Ravindra2, Barbara A. Wetmore3, Denise K. MacMillan3 1Oak Ridge Institute for Science and Education (ORISE), 2Oak Ridge Associated Universities (ORAU) 3U.S. Environmental Protection Agency, Office of Research and Development Introduction Experimental Coumarin Verapamil Conclusions Rosiglitazone The U.S. EPA, in collaboration with Unilever, is developing new approach methods (NAMs) to quickly evaluate chemicals for human health hazards. Incorporating metabolism in NAMs is important to evaluate both parent compound and metabolite exposures during risk evaluations. Here, untargeted LC- MS/MS analysis is used to characterize metabolism of Coumarin, Rosiglitazone, and Verapamil in human hepatocyte suspensions and S9 protein fractions, and rat S9 protein fractions. Human hepatocytes are the gold standard for evaluating metabolism, but S9 fractions are easier to use and are not limited by toxicity. O O Rosiglitazone DTXSID7037131 Verapamil DTXSID9041152 Coumarin DTXSID7020348 O O Top: (left) Abundance of the coumarin parent drug in each system. The Human S9 fractions showed the highest clearance. (right) Abundances of the detected coumarin metabolites Metabolite ID: (left) Each metabolite m/z value matched to two possible isomers. For C-Met-1a-b two features were detected while only one was detected for C-Met-2a-b. (right) Example of an MS/MS spectral match using MetFrag. MetFrag does not match abundances, only m/z values. All identifications were Level 2: Probable Structure on the Schymanski scale. Label m/z (M+H)+ RT (min) Matched Structure C-Met-1a-b 163.0389 5.60 and 6.25 C-Met-2a-b 339.0690 5.60 Label m/z (M+H)+ RT (min) Matched Structure R-Met-1 344.1072 5.69 R-Met- 2a-d 374.11 5.61, 5.80, 6.60 O S NH O O N + N CH3 O – O S NH O O N N CH3 OH Label m/z (M+H)+ RT (min) Matched Structure V-Met-1 196.1325 5.22 V-Met-2 291.2048 6.08 V-Met-3a-c 441.2739 (total) 6.50 and 6.70 V-Met-4a-c 471.285 6.15, 6.41, and 6.59 V-Met-5a-b 427.2568 6.48 V-Met-6a-b 457.2678 6.55 NH O O O O CH3 C H3 C H3 CH3 C H3 N CH3 N O O O O H CH3 CH3 C H3 CH3 C H3 N CH3 N OH O O O CH3 C H3 C H3 CH3 C H3 N CH3 N O O O O CH3 CH3 C H3 C H3 CH3 C H3 CH CH3 OH N O O O O CH3 CH3 CH3 C H3 CH3 C H3 N CH3 OH N O O O O CH3 CH3 C H3 C H3 CH3 C H3 N CH3 OH NH O O O O CH3 C H3 C H3 CH3 C H3 N CH3 OH NH O O O O CH3 C H3 C H3 CH3 CH3 N C H3 OH NH O H O O O C H3 C H3 CH3 C H3 N CH3 C H3 NH O O O O H C H3 CH3 C H3 N CH3 A B A B A B C D A B C A B C A B A B Top: (left) Abundance of the verapamil parent drug in each metabolic system. The human S9s showed the highest clearance. (right) Abundances of the detected verapamil metabolites in each system. Metabolite ID: All metabolites were annotated as Level 2 except for V-Met-1 for which no MS/MS was acquired (Level 5: Accurate mass only). Many metabolite MS/MS spectra matched to two or more isomers. Two metabolites were detected that were not predicted. They were annotated the same way as the others. N O O O O CH3 CH3 C H3 C H3 CH3 C H3 N CH3 Top: (left) Abundance of the rosiglitazone precursor. The rat S9s showed the highest clearance. (right) Abundance of the detected rosiglitazone metabolites. Metabolite ID: All matched structures were considered Level 2: Probable Structure on the Schymanski scale. R- Met 2a-d matched to four possible isomers despite three m/z values being detected. Level 2: Probable Structure 50 100 150 200 m/z Experimental MetFrag Not Predicted Not Predicted • Metabolism was compared between three different systems: human hepatocytes, human S9 fractions, and rat S9 fractions which all differed slightly in the metabolites observed. • Human liver S9s contain the native enzymes present


INTRODUCTION CONCEPTUAL FRAMEWORK OBJECTIVE To explore first contact physiotherapist service rapid adaptation for musculoskeletal conditions during Covid-19 pandemic in the UK and Australia Healthcare services initially experienced disruption due to Covid- 19 pandemic, for example, World Health Organisation reported 53% disruptions in primary care services and 38% in emergency care globally. However, services quickly adapted for the continuity of care There is currently no evidence on the adaptation strategies implemented by first contact physiotherapy (FCP) services since the onset of the pandemic and how they have been experienced by patients and staff There is a need to describe this process and identify barriers and facilitators in the implementation of this change to understand and reflect on the experience of the service providers and users for future practice Adaptation framework, World Health Organisation Responsiveness framework and Dearing Readiness tool will be combined to understand adaptation and its associated factors RESULT/CONCLUSION EXPLORING ADAPTATIONS TO FIRST CONTACT PHYSIOTHERAPY SERVICES FOR MUSCULOSKELETAL PATIENTS DURING COVID-19 PANDEMIC AFFILIATIONS 1) School of Health Science, University of Surrey 2) School of Nursing, University of the Highlands and Islands 3) University of Wollongong, Australia AUTHORS Oluwatoyin A. Adeniji Dr Theopisti Chrysanthaki Dr Karen Stenner Dr Nicola Carey Prof Evangelos Pappas Prof Victoria Traynor METHODS A cross-sectional study design will be used to explore changes that occurred in FCP service delivery for Musculoskeletal patients during the Covid-19 pandemic in the UK and Australia using an online survey (Qualtrics©). The online survey (questionnaire) was developed a priori, drawing on literature and consultation with experts. About 439 FCP practitioners will be recruited through physiotherapy associations both in the UK and Australia. ANALYSIS Data will be imported into SPSS and analysed using descriptive statistics of mean, frequencies, and percentage. Content analysis will be used to analyse responses to open-ended questions to provide numerical counts of categories where appropriate. RELATED LITERATURE AL AWAJI, N. N., ALMUDAIHEEM, A. A. & MORTADA, E. M. 2022. Changes in speech, language and swallowing services during the Covid-19 pandemic: The perspective of speech-language pathologists in Saudi Arabia. PLoS One, 17, e0262498. BARTON, C. J., EZZAT, A. M., MEROLLI, M., WILLIAMS, C. M., HAINES, T., MEHTA, N. & MALLIARAS, P. 2022. “It's second best”: A mixed-methods evaluation of the experiences and attitudes of people with musculoskeletal pain towards physiotherapist delivered telehealth during the COVID-19 pandemic. Musculoskeletal Science and Practice, 58. MARSHALL, J., SCOTT, B., DELVA, J., ADE, C., HERNANDEZ, S., PATEL, J., MORENO-CHEEK, M., ROJAS, D., TANNER, J. P. & KIRBY, R. S. 2020. An Evaluation of Florida’s Zika Response Using the WHO Health Systems Framework: Can We Apply These Lessons to COVID-19? Maternal and Child Health Journal, 24, 1212-1223. STIRMAN, W. S., BAUMANN, A. A. & MILLER, C. J. 2019. The FRAME: an expanded framework for reporting adaptations and modifications to evidence-based interventions. Implementation Science, 14. DEARING, J. W. 2018. Organizational Readiness Tools for Global Health Intervention: A Review. Front Public Health, 6, 56. This study will provide an overview of changes that have occurred in FCP service delivery for musculoskeletal patients and its associated factors in the UK and Australia. This will provide an opportunity for cross-contextual learning and may inform future practice. Contact o.adeniji@surrey.ac.uk Twitter: @Adenijimojisola LinkedIn QR code 1,3 1 1 2 3 3


RESULTS METHODS INTRODUCTION Fig. 1: A, C. eucalypti; B, B. occidentalis; C, G. brimblecombei; D, S. cf. plicatuloides; E- H, infestation of the respective psyllids on eucalypt leaves and shoots; I, P. pilosus (known parasitoid of A); J, P. blastopsyllae (known parasitoid of B); K, P. bliteus (known parasitoid of C). Table 3: Antennation, probing and oviposition attempts by P. blastopsyllae when exposed to B. occidentalis, G. brimblecombei and C. eucalypti; and of P. bliteus when exposed simultaneously to G. brimblecombei and S. cf. plicatuloides, in choice tests. The known host psyllid of each parasitoid is indicated in bold. No-choice host specificity testing Behavioural assay • The three Psyllaephagus species were collected from their known hosts. • Each Psyllaephagus species was separately exposed to B. occidentalis, C. eucalypti, G. brimblecombei and S. cf. plicatuloides. • Antennation, probing and oviposition behaviour of the parasitoids was monitored for 3 h. Choice host specificity testing • Based on the results of the no-choice tests, host preference of P. blastopsyllae was tested between G. brimblecombei, C. eucalypti and B. occidentalis, and host preference of P. bliteus was tested between G. brimblecombei and S. cf. plicatuloides, using the same methods as for the no- choice tests. No-choice host specificity testing Parasitoid development assay • The four psyllids were reared on their hosts. • For each psyllid-parasitoid combination, 10 infested trees were sleeved and a pair (female and male) of the parasitoid was introduced. • After 40 days, the number of Psyllaephagus wasps that emerged from the sleeve was recorded. Table 2: Average numbers of parasitoids that emerged from the test psyllid species and known hosts in the para- sitoid development assays. The known host psyllid of each parasitoid is indicated in bold. REFERENCES 1. Bush SJ, Slippers B, Dittrich-Schröder G, Hurley BP. 2020. Host specificity tests reveals new host of a global biological control agent Psyllaephagus bliteus (Hymenoptera: Encyrtidae. African Entomolo- gy 28: 238–248. 2. Hodkinson ID. 1999. Biocontrol of Eucalyptus psyllid Ctenarytaina eucalypti by the Australian parasi- toid Psyllaephagus pilosus: a review of current programmes and their success. Biocontrol News and Information 20: 129–134. ACKNOWLEDGEMENTS Tree Protection Co-operative Programme (TPCP), DSI – NRF Centre of Ex- cellence in Plant Health Biotechnology, University of Pretoria, South Africa for financial support. DISCUSSION AND CONCLUSION • P. pilosus only parasitised nymphal instars of C. eucalypti, its known host, which agrees with previous observations [2]. • G. brimblecombei was identified as a potential new host for P. blastopsyllae, and S. cf. plicatuloides was confirmed as an alternate host for P. bliteus. • Our findings indicate that some Psyllaephagus spp. have a wider host range, whereas others are highly host specific. Future work • Determine relative parasitism of the Psyllaephagus spp. on their different psyllid hosts in natural (Australia) and planted (e.g. South Africa) eucalypt forests. • Increase our knowledge on the host range of Psyllaephagus spp. in their native range, to inform future biological control programmes. • Two free-living eucalypt-feeding psyllids, Blastopsylla occidentalis and Ctenarytaina eucalypti, and two lerp-forming eucalypt-feeding psyllids, Glycaspis brimblecombei and Spondyliaspis cf. plicatuloides, all native to Australia, have been accidentally introduced into South Africa (Fig 1A-D). • The pest status of these psyllids varies but damage to eucalypts include bud degeneration, necrosis, defoliation, dieback and death (Fig 1E-H). • The co-evolved parasitoids (Psyllaephagus spp.) of three of the psyllid species were unintentionally intro- duced into South Africa with their insect hosts (Fig 1I-K). • A previous study showed that the parasitoid of G. brimblecombei, namely, Psyllaephagus bliteus, also parasitised S. c.f. plicatuloides [1],


Cultivando Consciência Ambiental desde a Infância: A Importância da Educação Ambiental nas Escolas para Crianças e Jovens Izomar Silva Amorim Mestrando em Educação pela UniNorte PY Professor de Ciências na rede Municipal e Estadual de Manaus Universidade Nilton Lins, AM Resumo A crescente preeminência da preocupação ambiental e da busca por respostas aos desafios globais relacionados ao meio ambiente tem se manifestado nas últimas décadas de maneira notória. Este cenário é marcado pela emergência de questões prementes, tais como as mudanças climáticas, a redução da biodiversidade, a degradação dos ecossistemas e a escassez de recursos naturais, cuja importância não pode ser subestimada e deve ser ressaltada dentro da sala de aula, pois ela desempenha um papel fundamental na formação das futuras gerações, promovendo a conscientização , a conexão com o meio ambiente e o desenvolvimento de valores e comportamentos sustentáveis de crianças e jovens. Neste trabalho, foi realizada uma reunião de conteúdos de artigos científicos em bases de dados como Scielo e Google acadêmico. Nesse contexto, este artigo teve o objetivo de apresentar a importância da abordagem do ensino da sustentabilidade para os discentes nas escolas, a forma como se manifesta de maneira a impactar o cotidiano dos estudantes e os desafios do futuro face ao agravamento dos desafios ambientais e à imperiosa urgência de fomentar a sustentabilidade. Esta modalidade educacional assume, portanto, um papel fundamental na configuração da consciência, valores e condutas das atuais e vindouras gerações, exercendo influência de notório alcance em múltiplos domínios. Palavras-chave: Ambiental, recursos, desenvolvimento, conscientização. III CONGRESSO AMAZONENSE DE EDUCAÇÃO Maysa Girlane Araújo Amorim Mestranda em Educação pela UniNorte PY Coordenadora do PNAIC pela SEMED-Manaus de 2013 a 2016 e pela UNDIME/Am de 2017 a 2018 Universidade Estadual do Amazonas - UEA, AM Introdução O território brasileiro é notório por abrigar riquezas naturais de relevância inegável. No entanto, é incontestável que a degradação progressiva e a exploração desenfreada desses recursos têm desencadeado impactos adversos que repercutem de maneira nociva, tanto sobre os próprios recursos naturais quanto sobre a qualidade de vida das comunidades envolvidas. Esses impactos nefastos pressagiam desafios de ordem socioambiental e econômica, cujas ramificações se estendem não somente ao presente, mas também lançam sombras ameaçadoras sobre o horizonte das gerações vindouras. O horizonte de um futuro sustentável representa uma visão abraçada globalmente, mas sua realização plena repousa inteiramente nas decisões que tomamos no presente. Hodiernamente, somos confrontados por desafios de grande magnitude, que abarcam desde os imperativos das mudanças climáticas e a depreciação do ecossistema até as complexidades das questões relacionadas à desigualdade social e a crescente escassez de recursos. Entretanto, é de suma importância internalizar que a concretização de um futuro sustentável é tangível, desde que abracemos ações imediatas. Autores de renome, a exemplo de Paulo Freire, ressaltam que a educação ambiental confere às pessoas a capacidade de engajamento efetivo no processo de tomada de decisões pertinentes ao meio ambiente. Este processo, por sua vez, constitui um estímulo à cidadania ativa, fomentando a participação democrática em pautas ambientais. Conforme as ponderações de SEGURA (2001), a educação ambiental se erige como um meio de capital importância na possibilidade de reformulação do paradigma de degradação ambiental que prevalece. As abordagens educacionais relacionadas a esta temática podem desempenhar um papel de cariz transformativo, conferindo, assim, aos indivíduos, uma vez imbuídos de consciência, uma posição fulcral na promoção do desenvolvimento sustentável. Logo, embora a EA não se restrinja estritamente ao contexto do ensino formal, é imperativo considerar sua inserção prioritária no âm


HI grouping overlaid on DES RGB image A serendipitous MeerKAT discovery of an HI-rich grouping of galaxies with megaparsec-scale ﬁlamentary-like structure Overview ●Probing HI in a group environment ●Serendipitous MeerKAT HI grouping discovery ●In the foreground of Abell 3365 at z~0.04 MeerKAT data ●MeerKAT L-band observations (as part of MeerKAT Galaxy Cluster Legacy Survey) ●Combination of 2 ⨉ ~10 hour observations ●4k mode, ~209 kHz channel width (46 km s-1 at z~0.04) ●~52 µJy/beam channel RMS at a Briggs robust weighting of 2 Ancillary data ●DES, an optical imaging survey carried out by the Dark Energy Camera (DECam), we use g, r, i bands for optical counterpart identiﬁcation ●WISE, mid-infrared data used in calculation of stellar mass and star formation rates, where possible Name: Graham Lawrie Email: grahamdavidlawrie@gmail.com Prof. Roger Deane1,2 Prof. Romeel Davé3,4 1. University of the Witwatersrand 2. University of Pretoria 3. University of Edinburgh 4. University of the Western Cape Source-ﬁnding ●Visual source-ﬁnding within the HI data cube using CARTA ●Semi-automated source-ﬁnding with SoFiA 2, using a S+C threshold of 3.4 ●Crossmatching is done using the visual and SoFiA generated catalogues, together with false positive removal with the help of DES imaging Grouping ●We take a simplistic friends of friends approach to qualitatively associate galaxies ●Linking parameters of 1.3 Mpc spatial separation and 350 km/s in velocity separation Conclusion ●We made a serendipitous discovery of an HI-rich galaxy group with numerous galaxy-galaxy interactions shown by HI bridges and tails ●MeerKAT provides us with a powerful tool for probing the environmental effects on cold gas evolution ●MeerKAT appears to be particularly successful at detecting groups of galaxies at z~0.04, potentially providing astronomers with a useful environment in which to probe galaxy evolution Comparison to hydrodynamical simulation ●We compare the MeerKAT group detection to predictions derived from cutting edge cosmological hydrodynamical simulation, SIMBA Davé et. al. 2019 ●FoF is run on the ﬂagship SIMBA box with full physics to ﬁnd 31 analogous HI galaxy groups ●By comparison of the volume a MeerKAT pointing will probe out to z~0.1 we ﬁnd the likeliness of a HI group detection to be 1 detection per ~15 pointings ●Future work includes construction of mock HI galaxies with MARTINI for individual galaxy comparison, see the following example: Acknowledgements: SARAO for data and funding, ILIFU for access to HPC for data reduction, CARTA for data visualisation, SoFiA 2 for source-ﬁnding, SoFiA Image Pipeline for cutout generation, MARTINI for mock data generation, Wits-UK foundation for funding a 6 week research visit to Edinburgh ● HI total intensity HI velocity ﬁeld DES g-band


Not targetable No mutation Level 1 ( n = 55, 35%) PIK3CA (n = 32, 20%) HRD genes (n = 20, 14%) Level 2 (n = 7, 4%) Level 3 (n = 3, 2%) Level 4 (n = 10, 6%) Table 1: Clinical and histopathological characteristics of the cohort. FPN 139P Genomic prognostic and potential theragnostic factors in anal squamous cell carcinoma treated with abdominoperineal resection Conclusion • In patients with HPV-positive ASCC treated by APR, PIK3CA exon 9/20 and KMT2C pathogenic variants are independent prognostic factors of overall survival. • The high prevalence of alterations with potential theragnostic value strongly supports the use of genomic profiling to allow patient enrollment in precision medicine clinical trials. A. Hamza1, J. Masliah-Planchon1, C. Neuzillet2, J. H. Lefèvre3, M. Svrcek4, S. Vacher1, C. Bourneix1, M. Delaye2, D. Goéré5, P. Dartigues6, E. Samalin7, M. Hilmi2, J. Lazartigues2, E. Girard8, J. Emile9, E. Rigault10, V. Dangles-Marie11,19, N. Rioux-Leclercq12, C. de la Fouchardiere13, D. Tougeron14, A. Casadei-Gardini15, P. Mariani16, F. Peschaud17, W. Cacheux18, A. Lièvre10,20, I. Bièche1,21 abderaouf.hamza@curie.fr 1: Genetics Department, Institut Curie, PSL Research University, Paris, France, 2: Medical Oncology Department, Institut Curie, PSL Research University, Saint-Cloud, France, 3: Sorbonne Université, Department of Digestive Surgery, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Antoine, Paris, France, 4: Pathology Department, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, France, 5: Digestive Surgery Department, Gustave Roussy Institute, Villejuif, France, 6: Pathology Department, Gustave Roussy Institute, Villejuif, France, 7: Medical Oncology Department, Institut du Cancer de Montpellier, Montpellier, France, 8: INSERM U900 Research unit, Institut Curie, PSL Research University, Paris, France, 9: Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris, UVSQ, BECCOH, Hôpital Ambroise-Paré, Pathology Department, Boulogne-Billancourt, France, 10: Gastroenterology Department, Rennes University Hospital, Rennes, France, 11: Laboratory of preclinical investigation, Translational Research Department, Institut Curie, PSL Research University, Paris, France, 12: Pathology Department, University Hospital of Rennes, Rennes, France, 13: Medical Oncology Department, Centre Léon Bérard, Lyon, France, 14: Department of Gastroenterology and Hepatology, Poitiers University Hospital, Poitiers, France, 15: Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy, 16: Department of Surgery, Institut Curie, PSL Research University, Paris, France, 17: Department of Digestive and Oncologic Surgery, Ambroise Paré Hospital, Versailles Saint-Quentin University, Paris Saclay University, Boulogne-Billancourt, France, 18: Medical Oncology Department, Hôpital Privé Pays de Savoie, Annemasse, France, 19: Faculty of Pharmaceutical and Biological Sciences, Paris Cité University, Paris, France, 20: Rennes 1 University; Inserm U1242, COSS (Chemistry Oncogenesis Stress Signaling), Rennes, France, 21: INSERM U1016, Faculty of Pharmaceutical and Biological Sciences, Paris Cité University, Paris, France Background • The management of anal squamous cell carcinoma (ASCC) has yet to benefit from the progress of precision medicine. • The few prognostic factors assessed to date are insufficient to accurately predict clinical outcomes. • Genomic analyses could identify new prognostic biomarkers and potential avenues for targeted therapies. HPV status Characteristic N Overall, N = 158 Positive, N = 1411 Negative, N = 171 p-value2 Age 158 57 (49, 66)1 58 (50, 66) 52 (49, 62) 0.43 Sexe 158 0.001 Female 102 (65%) 97 (69%) 5 (29%) Male 56 (35%) 44 (31%) 12 (71%) Stage 145 0.47 I 14 (10%) 11 (9%) 3 (20%) II 70 (48%) 63 (48%) 7 (47%) III 59 (41%) 54 (42%) 5 (33%) IV 2 (1%) 2 (2%) 0 (0%) ypT 156 0.15 ypT1 19 (12%) 19 (14%) 0 (0%) ypT2 60 (38%) 50 (36%) 10 (59%) ypT3 32 (2


Polyclads from the Gulf of Mexico


Potential participants who meet the inclusion criteria are invited to participate in the study. Following informed consent, participants complete a graded treadmill exercise test conducted in the Cardiology Department to determine the participant’s exercise status, possible underlying cardiac disease and to outrule any contraindication to participation in an exercise programme. RESULTS During the period November 2006 to November 2007, 394 patients (residing within geographical proximity to Beaumont Hospital) with ABIs < 0.9 were identified from the Non-Invasive Vascular Laboratory Segmental Pressures records. Of the 394 patients identified, 271 medical charts were available for review. Seventy-nine of the 271 patients (29%) met the inclusion criteria. One hundred and eighty –seven patients were excluded. Reasons for exclusion are illustrated in Figure 1. Recruitment to Exercise Programmes: Challenges in the Peripheral Arterial Disease Population Guidon M1, Chavira M1, McGee H2, Sheahan R3 and Kelly C4 1 School of Physiotherapy, Royal College of Surgeons in Ireland; 2Psychology Department, Royal College of Surgeons in Ireland, 3Cardiology Department, Beaumont Hospital; 4Vascular Surgery Department, Beaumont Hospital INTRODUCTION Current evidence suggests that 27 million people in Europe and North America have peripheral arterial disease (PAD)1. Although only 3% of patients with intermittent claudication (IC) require amputation, a significant number will require hospital admission and other surgical intervention for IC and associated cardiac and cerebrovascular complications. An important aim of exercise therapy in the peripheral arterial disease population is to decrease cardiovascular risk factors and consequent morbidity and mortality. Several studies have demonstrated that exercise programmes result in significant improvements in walking distances but the long-term benefits are unknown. A randomised controlled trial is currently being conducted in Beaumont Hospital to determine the effects of a supervised exercise programme on quality of life, risk factor modification and morbidity and mortality in patients with PAD. AIM This is a report of ongoing recruitment to the trial whereby participants are randomly allocated to either a control or an exercise group. The aim is to determine the uptake to a 12 week (twice weekly) supervised exercise programme and to identify factors which promote and impede uptake. Figure 2. Exercise Testing Outcomes DISCUSSION Although the risk factors for PAD are the same as those for coronary artery disease, individuals with PAD face considerable challenges to exercise due to their symptomatology. Walking is associated with the onset of leg pain and frequent rest periods during walking are required to relieve the pain. To date the recruitment profile in this study population is similar to the recruitment profile for exercise programmes and cardiac failure (CF) populations with a high level of co-morbidity identified3. This highlights the importance of early detection of IC in primary care. The reasons for non-participation in this study are also similar to those in the CF populations i.e. lack of motivation, work/time conflicts, domestic responsibilities and transport difficulties. CONCLUSION Recruitment to this study is ongoing. However these results highlight the significant recruitment challenges presented by this clinical population. In addition to the traditional barriers to recruitment, barriers in this patient population also include a reluctance to exercise due to leg pain, an acceptance of reduced mobility as part of aging and a fear of exercise equipment. REFERENCES 1. Regensteiner J and Hiatt W (2002). Current medical therapies for patients with peripheral arterial disease: a critical review. American Journal of Medicine, 112, 49-57. 2. ACSM’s Guidelines for Exercise Testing and Prescription. (2000). Lippincott, Williams and Wilkins. 3. Lloyd-Williams et al (2003). Why are patients in cli


1. RATIONALE Keep data safe and unaltered for 20 years in a closed off-site storage system Retain original data for audit in case questions about the integrity of a research article are raised Increase compliance with Crick’s core funders’ data management requirements Improving the integrity of research data: building an institutional data archive Minna Ventsel, Research Integrity & Data Specialist The Francis Crick Institute minna.ventsel@crick.ac.uk 3. DATA ARCHIVING FLOW • Crick’s Figshare repository – option to select and upload data files to Figshare at the same time as archiving to increase openness • Metadata fields filled out automatically by the system, drawing details from an uploaded manuscript – to make archiving as easy as possible 2. THE SOLUTION Ticket creation •Researcher submits their manuscript to a journal •Researcher submits a ticket to inform the Library & Information Services team about their manuscript submission •Once ticket submitted, the Data Integrity team creates an archiving folder in researcher’s lab storage space Data •Researcher adds raw data associated with the manuscript to the archiving folder and informs the RI team when completed •The Data Integrity team conducts checks on data/metadata Archiving •Submission approved by the RI team and sent to the archiving team •Data encrypted and compressed •Data is archived in tape storage off-site and cannot be altered – data can now only be retrieved by request Creation of a team to oversee the project and discuss the needs of the archive System design & architecture team come up with the most feasible technology solution IT team start building the system. Preliminary test with one lab at the Crick Wider testing with 2-3 labs Identification of any issues and feedback from users Final changes before official launch First image by pch.vector on Freepik Second image by storyset on Freepik 4. FUTURE INTEGRATION IDEAS


Manufacturing Capability of Micro-Transfer Printing X-Celeprint Inc., Research Triangle Park, NC, www.x-celeprint.com, dgomez@x-celeprint.com David Gomez, Tanya Moore, Matthew A. Meitl, Salvatore Bonafede, Andrew Pearson, Brook Raymond, Tiffany Weeks, Kevin Oswalt, Erich Radauscher, David Kneeburg, Julia Roe, Alin Fecioru, Steven Kelleher, Raja Fazan Gul, Alexandre Ferrell, Antonio Jose Trindade and Christopher A. Bower


High Precision Robotic Navigation and Sensing Jiazhe Tang Dr. Rodrigo Aviles-Espinosa Dr. Elizabeth Rendon-Morales jt558@sussex.ac.uk e.rendon-morales@sussex.ac.uk r.aviles-espinosa@sussex.ac.uk School of Engineering and Informatics, University of Sussex, Brighton, UK Machine vision system for quantification of aortic and pulmonic valvuloplasty catheter compliance Reference [1] F. C. A. Groen, I. T. Young, and G. Ligthart, ‘A comparison of different focus functions for use in autofocus algorithms’, Cytometry, vol. 6, no. 2, pp. 81–91, Mar. 1985, doi: 10.1002/cyto.990060202. [2] University College London, China et al., ‘Valvuloplasty Balloon Catheter Sizing Approach for Calcified Aortic Valve with Different Annulus Ratios’, in Proceedings of The 15th Hamlyn Symposium on Medical Robotics 2023, The Hamlyn Centre, Imperial College London London, UK, Jun. 2023, pp. 37–38. doi: 10.31256/HSMR2023.19. [3] X. Huang, E. Rendon-Morales, and R. Aviles-Espinosa, ‘ROMI: Design and Experimental Evaluation of a Linear Delta Robotic System for High-Precision Applications’, Machines, vol. 11, no. 12, p. 1072, Dec. 2023, doi: 10.3390/machines11121072. Introduction Research Gaps Experiment Methods & Results Balloon aortic valvuloplasty (BAV) is a simple and low-cost treatment for patients with severe aortic stenosis, for aortic valve replacement and to select the proper transcatheter heart valve (THV) size. During THV implantation choosing the correct balloon size is paramount to reduce the risks of coronary occlusion, annular damage or THV embolization. In this research, we present a non-contact metrology system for BAV measurement based on a high precision robotic system equipped with a five elements brightfield microscope system. The robot is controlled though a custom-made GUI operated though an FPGA. The balloon initial diameter is determined optically. Upon ballon inflation, the defocused image is then refocused though passive focusing algorithms used to identify the best focal position. Current methods for selecting the proper balloon dimensions are based on transoesophageal echocardiography and computed tomography all these requiring exposing the patients to high doses of radiation [1]. Moreover, the images require to be analysed by specialized staff. Alternative methods propose the use of BAV to determine the correct THV size using a sterile calliper [2]. This, being a contact-based measurement may compromise the measurement accuracy. Sterile Calliper [2] ROMI [3] Transoesophageal Echocardiography Computed Tomography [1] Each focus evaluation function has its own array of scores. We normalize each of these arrays individually and then plot the results. Balloon with 1 Atmosphere, All Focus Methods Test Results Conclusion • Current results considering algorithms such as the Absolute Tenengrad based on image differentiation, Vollath‘s F4 based on correlation measurement, and Normalized Variance based on statistics, shows that the selected focus algorithms are able to converge at the same focal position. • It allowing for a fast and precise BAV balloon calibration with sub-millimetre accuracy <10 um showing the potential of the here presented work to be used in medial settings to automate preoperative balloon characterization. • Future work will focus on measuring the initial size of the balloon, and according effective passive automatic focus method to determine the change of the size of the balloon. Balloon with 1 Atmosphere, Effective Focus Methods Test Results Not Focused Focused • Set initial position. (Position C) • Down to position A. • Start autonomy moving. • Go to A, go to B, then go to A. • It should pass the best focus point twice, which will give back two peak on the results of the focus evaluation function diagram.


Vendula Smolikova PhD student vendula.smolikova@vub.be Acknowledgements: This work was supported by the project PROFISH CZ.02.1.01/0.0/0.0/16_019/0000869. The DGT passive samplers can not only overlap the lack of knowledge in the biogeochemical cycling of trace elements and their bioavailability for living organisms but they also represent a useful tool for long-term monitoring of trace metal concentrations in-situ. The field application of new DGT designs utilizing different sorbents is a crucial part of the technique validation. The salinity gradient found in estuaries represents an ideal location for evaluation of the DGT technique performance which may be hampered by the complex composition of seawater in contrary to freshwater. The potential of Diffusive Gradients in Thin films (DGT) technique as a monitoring tool for uranium in the aquatic environment V. Smolikova1,2, P. Pelcova2, A. Ridoskova2, M. Leermakers1 1Department of Analytical, Environmental and Geochemistry, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium 2Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 613 00, Brno, Czech Republic INTRODUCTION • 2 campaigns in 2019 and 2020, • 6 replicates of DGTs with each sorbent per station, • S01–HEM deploymen for 24 h, • HZ1 deployment for 28 days, • water samples collected at each station for comparison of the dissolved uranium concentration with the DGT-determined U concentration. MATERIALS & METHODS An improper selection of the binding phase can lead to providing skewed results that do not correspond to reality. The results of this study demonstrate that thorough testing of the DGT technique in a natural environment is a crucial prerequisite for obtaining reliable data and application of the DGT as a speciation tool. Using selective sorbents (such as Diphonix) may provide a DGT design that has the potential not only to quantify the labile fraction of uranium that may pose a risk to biota but may be used as a long-term monitoring passive sampler in seawater. CONCLUSIONS RESULTS OBJECTIVES How can be the performance of various DGT designs influenced by utilizing sorbents with different functional groups? Is any of the DGT design able to provide time- weighted average concentrations of U over the long deployment time in seawater? • Four tested sorbents: • Chelex -100, • Diphonix, • PIWBA, • Lewatit FO 36.UO22+OH-UO22+CO32-UO22+PO43-UO22+ Cl- UO2 2+ Downstream Upstream • Uranium shows typical conservative behaviour with increasing salinity along the Scheldt estuary. • Chelex-100 and Lewatit FO 36 are not suitable for application in seawater (salinity > 5 and 18, respectively). Both sorbents are not selective for U and their binding sites are therefore saturated by other competing ions occurring in the complex matrix of seawater. • PIWBA and Diphonix sorbents gels provide overall comparable results with very good agreement between the DGT-determined U concentration and dissolved U concentration at all stations. • Only DGTs utilizing Diphonix sorbent are able to provide reliable and accurate results for U determination even even after 28 days of deployment in seawater.station HZ128 PSU Salinity U (µg L−1) Station 0.0 1.0 2.0 3.0 4.0 5.0 0 10 20 30 2020 0.0 1.0 2.0 3.0 4.0 0 10 20 30 2019 HEM S04 S07 S01 S09 S12 S15 S22 U (µg L−1) Salinity HEM S04 S07 S01 S09 S12 S15 S22 Station Diffusion of labile U species from the solution 0 2 4 6 8 10 12 14 16 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 S22 S15 S12 S09 S07 2020 0 5 10 15 20 25 30 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 HEM S22 S15 S12 S09 S07 S04 S01 2019 0.0 1.0 2.0 3.0 2 28 U (µg L−1) Deployment time (days) Diphonix Chelex-100 Dow-PIWBA Lewatit FO 36 Dissolved Chelex-100 Chelex filter Diphonix PIWBA Lewatit FO 36 Dissolved Salinity