Introduction Methodology Results Next steps References Acknowledgements A - Samples of diﬀerent insects (Honeybees, Solitary Bees and Bumblebees) were scanned in TIF format 16bit depth, 1920x1920 pixels. B - CT scans in Raw setup, without ﬁltering. In some cases was required in this process using python scripts (Figure 1). C - 3D model processed in the Blender 3D software, using automatic and manual tools for cleaning up (Figure 2). D - Model after cleaning up and with internal armature for rigging (Figure 3). E - Model in natural position, with wings ﬁxed, ready to be exported. F - Render model made in Blender cycles for scientiﬁc illustration. G- Voxelized model in Sim4Life ready for simulations (3.5GHz, 20M cells). 25 CT scans were processed in to 3D models STL format, ready to be used in RF-EMF simulations. Models were tested for compatibility with Sim4Life software. For some models reconstruction of missing parts as such wings and legs were necessary. Those were done using references from literature. For manual tasks, python scripts using Blender API workﬂows were created where was possible to automate the work. Scripts can generate simple structures like antennas and legs segments. [1] Thielens, et al. Scientiﬁc Reports 8(1), 3924, 2018. [2] Thielens, PE 690.021, 2021, doi: 10.2861/318352. - Insects are crucial for the sustainability of ecosystems. - Telecommunication antennas emit Radio-Frequency Electromagnetic Fields (RF-EMFs) that could aﬀect insects. As telecommunications evolve (from 4G to 5G), the exposure of insects to RF-EMFs is likely to vary [1]. - Near powerful antennas, pollinators like bees face relatively high levels of RF-EMF exposure. This exposure can cause biological reactions in insects [2], yet the consequences of RF-EMF exposure on insects remain uncertain [2]. ETAIN has received funding from the European Union’s Horizon Europe research and innovation program under grant agreement No. 101057216 To assess the absorption of RF-EMFs in insects by utilizing detailed anatomical 3D models derived from CT scans, and to develop adaptable models compatible with EMF simulation software for various simulation scenarios. In this poster we focus on the process of extracting CT scan data to 3D models. Conduct simulations across each model at frequencies (1.8, 3.5, and 26 GHz) to verify whole-body averaged absorbed power, speciﬁc absorption rates and absorbed power densities. This will facilitate the analysis of how the distinct shapes of insects inﬂuence the results of these simulations. Implement simulations on heterogeneous models by assigning varied dielectric properties to diﬀerent parts of the insects. This approach will enable a more detailed and accurate representation of real-world conditions. Additionally, undertake simulations that focus on the internal structures of insects, thereby providing deeper insights into the internal eﬀects of RF-EMF exposure. By executing these steps, the project aims to shed light on the complex interactions between electromagnetic ﬁelds and biological entities, oﬀering valuable data for both scientiﬁc understanding and practical applications in the ﬁeld of bioelectromagnetics. Goals Figure 3. Illustration of the processing method of a CT scan of Osmia bicornis. Figure 1. Bombus terrestris CT scan ﬁltering method. 1.1 - Raw CT scan ﬁle. 1.2 3D model extracted from 1.1. The insect fur creates extra volume and issues to process the 3D model. 1.3 Filtered CT scan with lower density structures as the fur removed. 1.4 Updated 3D model without problematic fur meshes. Figure 2. 3D Models processing steps in Blender. Scripts have been implemented to streamline data aggregation into a uniﬁed table, capturing species name, collection site, and date. Additionally, it compiles morphological metrics calculated in Blender alongside Sim4Life simulation parameters and outcomes, providing a consolidated view of each sample's characteristics and simulation data. 3D Models were created using C


Scientific Knowledge Graphs and Metadata Infrastructure Daan Broeder, Menzo Windhouwer, Michael Kurzmeier, Katja Moilanen CLARIN ERIC, KNAW/HuC-DI, OAEW, TAU-FSD Scientific Knowledge Graphs Scientific Knowledge Graphs (SKGs) have recently gained popularity as a rich metadata structure for describing research activities using triples. The idea that a fully connected graph better represents the real world than a hierarchical structure is now widely accepted. Current implementations are the OpenAIRE Research Graph, PID Graph (DataCite), Open Research Knowledge Graph (TIB), … OpenAIRE Graph data model Data Cite PID Graph content From Scholarly to Scientific Knowledge Graphs? Within the RDA WG SKG Interoperability Framework, some existing SKGs have been developing a standardised model for SKGs. However mainly from a perspective of publishing and measuring research output for funders. To better model the research process, entities and relationships involving data creation and processing, such as processing services and instruments, are needed The research communities collaborating in the OSTrails project are advancing this work in the SKG-IF WG. Metadata Interoperability: SKGs to the rescue? In the OSTrails project the creation of SKGs by communities is an important means for improving the Discoverability and Interoperability of the community resources. From the SSHOC science cluster a number of CLARIN, DARIAH and CESSDA partners closely collaborate. The SSHOC partners are working towards creating SKGs from their rich metadata catalogues: - CESSDA data catalogue (CDC) - CLARIN Virtual Language Observatory (VLO) - SSH Open Marketplace (SSHOMP) Existing SKG-IF model SSHOC science cluster use-cases Retrieve information from SKGs : 1.When a user creates a new item in the SSHOMP, users enter the PID and fields for the new item are populated with the results. 2.When a user visits a dataset in the VLO see if the creator has also resources in the CESSDA SKG. Metadata catalogue Metadata Repository SKG publishing JSON / RDF / … OAI-PMH +? JSONAPI + SPARQL + .. Std. vocabularies community metadata providers OAI-PMH + ? Metadata catalogue Metadata Repository SKG publishing JSON / RDF / … OAI-PMH +? JSON API + SPARQL + .. Std. vocabularies community metadata providers OAI-PMH + ? SKG based Information exchange SKGs exchanging information


Kosuke Namekata (National Astronomical Observatory of Japan, e-mail: kosuke.namekata@astro.nao.ac.jp)1 Hiroyuki Maehara1; Satoshi Honda2, Yuta Notsu3; Daisaku Nogami4; Kazunari Shibata4, and SMART & OISTER team collaborations (1) National Astronomical Observatory of Japan (NAOJ); (2) University of Hyogo; (3) Colorado University; (4) Kyoto University A Filament Erup/on and Coronal Mass Ejec/on from a Superﬂare on a Young Sun-like Star We report that our op*cal spectroscopic observa*on of the young solar-type star EK Draconis reveals the ﬁrst evidence for a stellar ﬁlament erupCon associated with a superﬂare on a young Sun-like star EK Draconis (Namekata et al. 2021 (or 2022), Nature Astronomy, 6, 241). We monitored EK Draconis for about 30 nights with the TESS’s op*cal photometry and ground-based spectroscopy, and ﬁnally detected a superﬂare in white-light and Hα. APer the superﬂare with radiated energy of 2.0x1033 erg, a blue-shiPed Hα absorp*on component with a large velocity of -510 km s-1 appeared. The temporal changes in the spectra greatly resemble the Sun-as-a-star spectra of solar ﬁlament erup*ons, indica*ng a common picture of solar and stellar ﬁlament erup*ons. The comparison of this stellar ﬁlament erup*on with solar ﬁlament erup*ons in terms of the length scale and velocity strongly suggests that this would eventually become a stellar CME. The mass of erupted ﬁlament of 1.1x1018 g is surprisingly 10 *mes larger than those of the largest solar CMEs. The huge ﬁlament erup*on and an associated CME on the young Sun-like star provide the ﬁrst opportunity to evaluate how the young Sun-like star/young Sun aﬀects the environment of young exoplanets/young Earth as well as stellar mass/angular-momentum evoluCon (cf. the faint young Sun paradox). 1. Introduc,on 3. Filament erup,on on young Sun-like star 2. Observa,ons 4. Sun-as-a-star analysis 5. Frequency of CMEs 7. References 6. Summary & Future Works 1. Namekata et al. 2021 online (or 2022a), Nature Astronomy, 6, 241(→) 2. Namekata et al. 2022b, ApJ Le?ers, 926,5 3. Namekata et al. 2022c, accepted (h?ps://arxiv.org/abs/2206.01395) [See, my talk in Splinter session “Solar and stellar coronal mass ejecOons” ] FIGURE 3: A solar ﬂare WITH ﬁlament erupOon. (middle) Light curve. (right) Dynamic spectrum of the Hα line (Namekata et al. 2021 (or 2022a), Nat. Astron.). What does the erup5ve event on EK Dra look like? To answer this quesOon, we conducted the Sun-as-as-star analysis of Hα spectrum of solar ﬁlament erupOons. As a results, spectral features are very similar to the event on EK Dra, indicaOng that the event on EK Dra was a large-scale ﬁlament erup5on whose picture is similar to those of solar ﬁlament erup5ons. Solar image Hα – 1Å ﬁlament ﬂare FIGURE 4: A solar flare WITHOUT a signature of filament eruption. In this case, strong redshifted & broadened spectrum can be seen (Namekata et al. 2022c, ApJ). ﬂare Velocity [km/s] Wavelength [Å] Impulsive Phase (ﬂare) Normalized Intensity Decay phase FIGURE 1: A stellar ﬁlament erupOon from a 2x1033 erg superﬂare on a young Sun- like star EK Dra. (le`) Light curve in Hα. (middle) pre-ﬂare subtracted spectrum (right) Dynamic spectrum (Namekata et al. 2021 (or 2022a), Nat. Astron.). We detected Hα spectra from superflares (1033-34 erg) on a young Sun-like stars for the first time. Surprisingly, one of them shows post-flare Hα dimming, and the Hα spectrum shows blue-shifted absorption component. We concluded that we detected a stellar filament eruption on young Sun-like star for the first time. FIGURE 2: Large velocity and length scale indicate that the ﬁlament erup5on eventually becomes stellar CMEs. ProperOes Velocity: -510 km/s Length scale: 500 Mm Mass: 1.1x1018 g (10 x the largest solar CME) Superﬂare FIGURE 5: NO ﬁlament erup5on signature in a 1034 erg superﬂare on a young Sun- like star EK Dra. (Namekata et al. 2022b, ApJ Le?ers). Other superﬂares DO NOT necessarily show ﬁlament erup5on signatures ⇒Signatures of ﬁlament erupOon


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Acknowledgements & Computational Resources References [1] Tan C. and McClements D. J., Foods , Apr. 2021, vol. 10, no. 4, p. 812 [2] Bai L., Huan S., Rojas O. J., and McClements D. J, J. Agric. Food Chem., Aug. 2021, vol. 69, no. 32, pp. 8944–8963. [3] Posocco P., Perazzo A., Preziosi V., Laurini E., Pricl S., and Guido S., RSC Adv., 2016 vol. 6, no. 6, pp. 4723–4729. [4] Yamashita Y., Miyahara R., and Sakamoto K., Cosmetic Science and Technology, Elsevier, 2017, pp. 489–506. [5] Álvarez Vanegas M. et al., J Mol Model, Dec. 2013, vol. 19, no. 12, pp. 5539–5543. Methodology Stability and Interfacial Phenomena of W/O Emulsions via Molecular Dynamics Luís G. Gómez Martínez1,4, Deisy G. Giraldo3,4, Marianny Y. Combariza2,5, Cristian Blanco Tirado2,5 & Aldo F. Combariza1,4 1 Departamento de Biología Y Química, Facultad de Educación y Ciencias, Universidad de Sucre. 2 Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander (UIS). 3 Institut des Sciences Analytiques et de Physico-chimie pour l’Environnement et les Matériaux, Université de Pau et des Pays de l’Adour. 4 Grupo de Investigación en Modelamiento Molecular y Simulación Computacional In silico, Universidad de Sucre. 5 Grupo de Investigación en Fisicoquímica Teórica y Experimental GIFTEX, Universidad Industrial de Santander. e-mail: luis.gomez@unisucrevirtual.edu.co , aldo.combariza@unisucrevirtual.edu.co We thank to Universidad de Sucre and Universidad Industrial de Santander for the support and in-silico & GIFTEX Research Group members for their support in the development of this work. We thank to QCC organizing committee for the opportunity to participate in this event. We thank to IAAPP for allowing us the access to INKARI cluster and to Ronald Apaza for his support. We also thank to Dr. Wilson Castro Silupu and Ronald Apaza for allowing us the link to INKARI. Motivation Results and Discussion Preliminary Conclusions Phospholipidic Emulsifier 1-Palmitoyl-2-oleoyl -sn-glycero-3-phosp hocholine (POPC) 1-palmitoyl-2-oleoyl-3-stearoyl-glycerol (POS) 1-palmitoyl-2-oleoyl-3-stearoyl-glycerol (POS) 1,3-Dipalmitoyl-2-oleoylglycerol (POP) 1,3-distearoyl-2-oleoylglycerol (SOS) Main triacylglycerols (TAGs) and Phospholipids present in Theobroma cacao L. Kirkwood-Buff simplified formulation Theoretical Interfacial tension (IFT) of Commercial and Cocoa Emulsions ( mN m) IFT γ of Pattern Commercial Emulsion: 2.74 mN m IFT γ of Pattern Cocoa Emulsion: 1.98 mN m Experimental IFT γ of Oil (Sunflower) and Water: 24.80 In which we consider the tangential componentes (Pt = Pxx + Pyy)/2) and the normal component (PN = Pzz) to the interfacial plane of Cauchy Stress Tensor. Water in Oil (W/O) Emulsion Oil in Water (O/W) Emulsion Mix Emulsification CHARMM-GUI Effective Simulation Input Generator and More Automated Topology Builder (ATB) and Repository Visual Molecular Dynamics Phosphatidylcholine (PC) Phosphatidylethanolamine (PE) Phosphatidylserine (PS) Phosphatidylglycerol (PG) Phosphatidylinositol (PI) Phosphatidic acid (PA) Temperature: 298 K Pressure: 1 Bar Force Field: CHARMM36 Statistical Ensemble: NVT (for minimization) & NPT (for equilibration and production simulations) GROMACS Version: 2019.3 Water Model: TIP3P Finally we run a simulation of production of 50 ns, NPT ensemble, under normal conditions of pressure and temperature Then we run a minimization of 10.000 nsteps (step size 2fs, 20 ps) within the NVT ensemble and six different equilibrations of 125.000 nsteps (250 ps) NPT ensemble under normal conditions of pressure and temperature Analysis of MD Trajectories System setup CHARMM-GUI TAG’s Topology files of molecules We select/download the TAG’s topology files (SOS and POP) from the ATB repository to set up the simulation cell ● MD simulations and trajectories showed that initial system of cocoa emulsions (with pure components) were well-equilibrated and the IFT values were ranged between 1-10 mN/m which are good values for emulsions. ● RDF graph showed pea


Contact us now info@csem.ch • www.csem.ch Developing high-performance and safe electrolyte for silicon and lithium metal batteries Sufu Liu, Leonardo Pires Da Veiga, Chengyin Fu, Mohammed Srout, Andrea Ingenito CSEM Sustainable Energy Center, CSEM SA, Switzerland In-situ thermally triggered polymer for silicon battery electrolyte Abstract: Compared with the state-of-the-art graphite anodes, silicon and lithium metal are considered as the most promising alternatives for higher energy density lithium batteries owning to their high theoretical capacity. However, significant challenges such as low coulombic efficiency, short cycle life and safety concern have seriously hindered their practical applications. [1,2] To enable the use of silicon anode, we are developing a polymer electrolyte with self-healing properties to stabilize the electrode interphase and restrain the huge volume change of silicon material. When compared with commercial carbonate liquid electrolyte with or without additives, our designed polymer electrolyte enables the NMC622//Si full cell with improved capacity retention and combustion resistance. Meanwhile, for rechargeable lithium metal batteries, our designed nonflammable electrolyte also enables the LFP//ultra-thin lithium metal (25 µm) with greatly extended cycling life, which delivers more than 88% capacity retention after 400 cycles. Our research paves the way for safer and more efficient lithium-ion batteries with silicon or lithium metal-based anodes, which will help to realize higher energy density and longer-lasting battery technologies. Conclusion and future work • In-situ thermally triggered polymerization is a promising method for fabricating polymer electrolyte with self-healing properties outperforming the commercial carbonate electrolyte. • Electrolyte engineering with aggregate and contact ion pair structures is an effective strategy to develop advanced electrolyte with high Li metal Coulombic efficiency. • Thermally evaporated thin Li metal and advanced electrolyte design could be an effective combination to promote long-term cycling of lithium metal batteries. References: [1] Park et al., Chem. Sci., vol. 14, pp. 9996-10024, (2023). [2] Narayan et al., Adv. Energy Mater. vol. 12, pp. 2102652, (2022). Advanced electrolyte for lithium metal battery • 99.6% Li Coulombic efficiency could be reached in the obtained electrolyte The mechanism diagram of in-situ polymerization of the thermally triggered polymer The structure design of the advance electrolyte for LMBs • Thermally evaporated Li metal with high purity • 88% capacity retention after 400 cycles has achieved when coupling the in-home prepared ultrathin Li anode with commercial LFP cathode 60% Si coin cell exhibits enhanced capacity retention 20% SiOx punch cell indicates stable cycling Building more reliable and performing batteries by embedding sensors and self-healing functionalities to detect degradation and repair damage via advanced Battery Management Systems Methodology • Develop self-healing battery materials and sensing devices. • Validate the triggering mechanisms and degradation detection. • Assess the manufacturing, recycling, and sustainability process and develop the Battery Management System. Consortium


ENRICHING THE EVIDENCE BASE OF CO-CREATION IN PUBLIC HEALTH WITH METHODOLOGICAL PRINCIPLES OF CRITICAL REALISM INTRODUCTION Meta-theory, such as Critical Realism (CR) provides a foundation for understanding and researching phenomena. CR, originating from Bhaskar's work, distinguishes between the real and observable world and encourages exploring complex social phenomena with a focus on causal mechanisms. Co-creation research lacks explicit meta-theoretical foundations, whereas CR is a convincing proponent for hypothesised mechanisms to have the strongest explanatory power, related to empirical evidence. This study aims to explore critical realism as a promising meta-theory providing clear methodological principles [1,2] to enrich the evidence base for co-creation in public health research. RESULTS + MAIN TAKE-HOME MESSAGES www.healthcascade.eu @health_cascade Health CASCADE is a Marie Skłodowska-Curie Innovative Training Network funded by the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement n° 956501 AUTHORS: MESSIHA, K (1); ALTENBURG, TM (1); SCHREIER, M (2); LONGWORTH, GR (3); THOMAS, N (4); CHASTIN, S (5,6); CHINAPAW, MJM (1) Critical realism methodological principles seem well-suited as a meta-theoretical framework for evidence-based co-creation in public health empirical research METHODS Scan me to connect on LinkedIn Free hand Google Scholar Litmaps Full text screening Formative synthesis output Deliberative meetings Summative synthesis output Assessing applicability and usability (real-life case study “KiA”* [3] + WP3-6 feedback) Figure: Information flow chart of paper selection Define event as an outcome of research; Review literature for concepts, studies, and evidence; Provide chronological narrative; Analyse co-creators' perspectives; Compile key components: Actors, Actions, Objects, Outcome. Explication of Events Identification of + detailing the critical/ important events as a set of related actions or changes that occur over time and have a particular outcome or goal. Identify + analyse the components of the contextual environment that influence the event. Clarify their connections in order to understand how such event is influenced. Explication of structure + context Identification of social (norms) + physical structure, contextual environment + their relationships as linked to the event(s) which occurred. Propose superior mechanisms for event explanation; Identify contextual entities, including affordances influencing behaviours; Note retroduction's has 4 types: overcoded, undercoded, creative + meta-retroduction. Retroduction Identification + explanation of underlying mechanisms that caused the observed events. Formulate hypothesis based on prior knowledge; Test using empirical methods, longitudinally; Analyse data for variable relationships; Evaluate results for empirical adequacy; Further assess to corroborate/ refute refined theories. Empirical corroboration About the validation/ ‘confirmation’ of proposed causal mechanisms through empirical testing. Use diverse theories, methods, data sources + investigators for comprehensive perspectives; Assess event analysis significance (non-definitive). Triangulation and multi-methods About using (i.e., combining and integrating) a variety of data types and sources, relevant theories, analytical methods + observers in a research study to identify causal relationships. Principle 1 Principle 2 Principle 3 Principle 4 Principle 5 CR Principles with convincing empirical parallels to KiA... Event: Childhood overweight (outcome). Explored literature and local data (KiA neighbourhood). Participatory Assessment: 3-4 group meetings (children, n=20), interviews with parents (n=27), professionals (n=9). Results: Childhood overweight identified as main issue, with insufficient physical activity and unhealthy diet as main risk factors. Actions: Unhealthy behaviours. Objects: School, home, neighbourhood. Needs assessment w


The breakdown of current gyrochronology as evidenced by old coeval stars Diego Godoy-Rivera(★), Joaquín Silva-Beyer, Julio Chanamé • Gyrochronology promises to deliver stellar ages for field main-sequence stars from rotation period measurements. • Before being widely used, the age- rotation relations must be comprehensively examined. • We develop a new method to test the state-of-the-art gyrochronology relations with old coeval stars. • In Figure 3, the members of Clusters show a better agreement with gyrochronology (highest peak), followed by the Wide Binaries. • We use Random Pairs as a control sample to calibrate the expected agreement for unassociated stars (assembled by disassociating the binary components). • The Random Pairs show a distribution in agreement with theoretical expectations (Expected ΔProt) • Our results demonstrate that the gyrochronology relations under study (Angus+19, Spada & Lanzafame 2020) do have predicting power, as the sets of coeval stars (Clusters, Wide Binaries) are in better concordance than the unassociated Random Pairs. • In Figure 4, we test the fractional agreement with gyrochronology as a function of age by using the different samples. • We find a good agreement for young ages (≲ 1 Gyr) , but a clear degradation towards older ages (≳ 2 Gyr). • This highlights the need for novel empirical constraints at older ages, which may allow revised gyrochronology calibrations. Fig. 2: Prot vs. color diagram for open clusters (top) and wide binaries (bottom). Silva-Beyer, Godoy-Rivera & Chanamé (2023) Fig. 4: Agreement of gyrochronology as a function of age, for the different samples. Context Results Conclusions References Fig. 1: Illustration of the rotation period test ΔProt,gyro (top), and examples of low and high ΔProt,gyro values (bottom). Fig. 3: Normalized distribution of ΔProt,gyro values for the different data samples. More centrally concentrated peaks mean better agreement with gyrochronology. Gyrochronology relations: • Angus et al. (2019) • Spada & Lanzafame (2020) Data sets: • Curtis et al. (2020) • Godoy-Rivera et al. (2018, 2021b) • Gruner & Barnes (2020) • Meibom et al. (2015) (★) diego.godoy.rivera@iac.es Method and Data For a given pair, it is the difference of Prot(expected)-Prot(measured) for the secondary given the primary’s gyrochrone fit • In Figure 1, we design an indicator that quantifies the (dis)agreement between coeval pairs and a given gyrochronology relation. • We run the test using samples of stellar pairs with coeval, rotating components, for a range of ages. • These correspond to open clusters and Kepler-field wide binary systems, as shown in Figure 2. Gyrochronology relation = Spada & Lanzafame (2020) Fraction of each sample with |ΔProt,gyro| ≤ N*σ ΔProt,gyro For more details, please see:


IMPORTANCE OF OCEAN HEAT CONTENT TO THE GLOBAL CLIMATE SYSTEM Eileen Maturi1, David Donahue2, Deirdre Bryne1 1. NOAA/NESDIS/STAR 2. NOAA/NESDIS/OSPO Ocean Heat Content (OHC) The Ocean Heat Content is a measure of the integrated vertical temperature from the 26o C isotherm to the sea surface where surface boundary conditions exist (area under the curve in Fig. 1). The 26o C isotherm defines the lower limit at which convection can develop and strengthen. Surface winds generate turbulent mixing within the uppermost part of the ocean; this layer is called the Mixed Layer, and can often reach depths of hundreds of meters. Turbulence associated with the Mixed Layer is responsible for providing a large reservoir of heat energy that can be tapped into by a tropical cyclone. This can intensify and extend the lifetime of the cyclone. Figure 1. Schematic of OHC calculation. The red shading shows the true OHC by integrating the black temperature profile. The dashed blue line shows the approximated temperature profile of the upper ocean. Summary The Madden Julian Oscillation (MJO) and the El Nino/La Nina oscillations have global impacts which affect all the basins. It is important to know the Ocean Heat Content of all the Ocean Basins to predict the rainfall patterns, tropical and mid-latitude cyclones and drought. All these phenomena are components of the Global Climate System. NOAA/NESDIS generates a daily suite of satellite-generated OHC products for the Atlantic and Pacific. There are plans to generate a suite of OHC products for the Indian Ocean. Operational Ocean Heat Content (OHC) Products IMPACTS • The OHC products are important to the monitoring and understanding of Coral Reef systems. Coral reefs are sensitive to unusually warm water. Increased Ocean Heat leads to the destruction of Coral Reefs. • Higher oceanic heat content leads to increased rainfall, which is beneficial for agriculture. • Increased oceanic heat content in the Northern Indian Ocean leads to increased summer monsoon rainfall in India. • Improved ecological forecasting leads to better management of fish stocks, which are an important food source for ocean-bordering countries. There is only one true ocean, the “World Ocean.” For simplicity, the World Ocean is divided into 5 interconnected ocean basins. They are the Atlantic, Pacific, Indian, Arctic, and Southern Oceans. Climatic Variability The Indian Ocean is the warmest of the 5 ocean basins. An Indian OHC product can provide information about the Madden Julian Oscillation (MJO), which is a major factor in determining rainfall, drought, and tropical cyclone patterns in the Eastern Hemisphere. MJO can be visualized as alternating regions of rising air and sinking air. The rising air is associated with tropical rainfall. The sinking air is associated with drier conditions, allowing more solar insolation to reach the ground, inducing drought. It can also play a role in strengthening or weakening tropical cyclones. In addition, the OHC can be used to gauge the strength and duration of the Indian, Asian and North American Summer Monsoons. The MJO typically moves across the tropical Indian Ocean and western Pacific before weakening; though it occasionally circumnavigates the global tropics in 30- 60 days (1-2 months). MJO differs from El Nino/La Nina primarily in that the MJO recurs more frequently (lasting 1-2 months),compared to El Nino/La Nina which recurs less frequently (lasting 6-9 months or longer). The OHC is especially important for the Atlantic and Pacific Basins to help gauge the intensity and duration of El Nino/La Nina, tropical and extratropical (mid- latitude) cyclones, and anomalous rainfall patterns.


Thibault Goessel*1,2, Simon Ligier1, Adélaïde Aublet-Mailhac1, Robin Girard2 / CONTEXTE ET OBJECTIFS Contexte • Le secteur du bâtiment représentait 25% de l’empreinte carbone de la France en 2019. Les émissions de carbone sont réparties sur toute la chaîne de valeur : environ 2/3 pour la phase d’exploitation du bâtiment et 1/3 pour la phase de construction et fin de vie [1]. 1) Développer une méthode d’identification des stratégies de rénovation optimales, basée sur l’évaluation des impacts sur le cycle de vie du bâtiment rénové. 2) Analyser l’influence du réchauffement climatique sur l’identification des stratégies de rénovation. / RÉSULTATS • La massification de la rénovation du parc existant apparaît comme un levier majeur de décarbonation. Des objectifs nationaux ambitieux ont été établis, comme l’atteinte en moyenne pour le parc d’ici 2050 du niveau Bâtiment Basse Consommation [2]. Il faudrait 700 000 à 1 million de rénovations performantes par an, contre 66 000 en 2022 [3]. • Des critères complémentaires existent pour juger de la performance d’une rénovation. Plusieurs études ont commencé à analyser l’influence du choix des critères sur les choix des stratégies de rénovation, en se focalisant principalement sur le coût et les émissions de gaz à effet de serre [4,5]. La prise en compte du confort est plus récente [6]. [1] Feuille de route décarbonation du bâtiment, 2023 [2] Plan rénovation énergétique des bâtiments, 2021 [3] Rapport activité Anah, 2022 [4] Amini Toosi et al., 2020, « Life Cycle Sustainability Asssment in Building Energy Retrofitting : A Review » [5] Galimshina et al., 2021, « What Is the Optimal Robust Environmental and Cost-Effective Solution for Building Renovation? Not the Usual One » [6] Mostafazadeh et al., 2023, « Energy, economic and comfort optimization of building retrofits considering climate change: A simulation-based NSGA-III approach » [7] Kraiem et al., « fTMY-Documentation », confidentiel [8] DGEC, 2023, « Synthèse du scénario « avec mesures existantes » 2023 de la Stratégie Nationale Bas Carbone » • Etude de cas sur une maison individuelle : bloc béton, à effet Joule, toit légèrement isolé, en Gironde (zone H2c), Cep=676 kWh/m²/an. • 800+ stratégies de rénovation mêlant les lots techniques : chauffage, refroidissement, ventilation, murs, toiture, fenêtres. • Taux d’actualisation de 3,2 %. Méthodologie prospective pour l’optimisation multicritère de la rénovation énergétique des bâtiments Objectifs CONFÉRENCE IBPSA FRANCE 13 AU 17 MAI 2024 LA ROCHELLE ET OLÉRON THIBAULT.GOESSEL@CSTB.FR 1 Centre Scientifique et Technique du Bâtiment (CSTB) 2 Mines Paris – PSL, centre PERSEE Thèse commencée le 21/11/2022 / MÉTHODOLOGIE • 12 stratégies sont sur le front de Pareto 3D (coût, carbone, inconfort thermique) :  L’intégralité rénove le système de chauffage (chaudière bois) et isole les murs (ITE fibre de bois 24cm).  La moitié rénove la ventilation (ventilation double flux). • La prospective climatique en année-type aggrave l’inconfort thermique (+200 à +400 °C.h) mais a des effets marginaux sur le coût total et l’empreinte carbone. • Le choix des stratégies optimales n’est que peu modifié par la prospective climatique : parmi les 12 stratégies sur le front de Pareto 3D en climat historique, 11 sont encore optimales en climat prospectif.


Extraction of historical information using semantic techniques and knowledge graphs Jorge Álvarez Fidalgo Introduction In the framework of the Semantic Web, knowledge graphs such as Wikidata have emerged as powerful tools to represent and or- ganise large amounts of information in a structured way (linked data). Our aim is to create a methodology that enhances the extraction of information from digitised historical documents by relying on external knowledge graphs, feeding them back in the process. Research questions •RQ1. How can we extract linked data from historical documents? •RQ2. Is it possible to use data from external knowledge graphs to improve the extraction process? •RQ3. Is it possible to detect errors and shortcomings in external graphs from the extracted information? •RQ4. How can we use NLP techniques to improve the accuracy of the linked data obtained? Methodology •To solve RQ1, we extract triples (?head, ?rel, ?tail). •In order to get all ?head -and some ?tail- entities we perform NER using existing M-BERT [1] derived models. •To extract ?rels we propose to perform link prediction on Wikidata in two phases -thus addressing RQ2-. Link Prediction (I). Semi-inductive prediction [2] using tail prediction models trained on Wikidata datasets, such as KGT5 [3]. To restrict the number of properties to be predicted, we use Shape Expressions [4]. Link Prediction (II). Fully inductive prediction [2] in which, based on the information extracted in (I), we define property paths in Wikidata -by means of SPARQL queries- that, if they exist between two entities, indicate a possible relationship between them. Preliminary results To evaluate this approach we are applying these techniques on a corpus of Spanish medieval notarial records consisting of 128 documents [5]. We focus on three types of relationships of varying difficulty for their detection: father-child, spouse and sibling, obtaining high recall [0.60-0.87] yet very low accuracy ([0.06-0.08]). Preliminary conclusions •Most of the relevant triples are extracted successfully. •Those undetected are mostly due to a) incomplete information in the knowledge graph (RQ3) and b) relationships that do not adhere to any pattern. •Accuracy is very low since many non-relevant pairs of entities match the patterns. •RQ4 may be of help in this regard, thus facilitating the work of the human-in-the-loop. Bibliography [1] Telmo Pires, Eva Schlinger, and Dan Garrette. How multilingual is multilingual BERT? In Proceedings of the 57th Annual Meeting of the Association for Computational Linguistics, pages 4996–5001, Florence, Italy, July 2019. Association for Computational Linguistics. doi: 10.18653/v1/P19-1493. [2] Mehdi Ali, Max Berrendorf, Mikhail Galkin, Veronika Thost, Tengfei Ma, Volker Tresp, and Jens Lehmann. Improving inductive link prediction using hyper-relational facts. In The Semantic Web – ISWC 2021, pages 74–92, Cham, 2021. Springer International Publishing. ISBN 978-3-030-88361-4. [3] Apoorv Saxena, Adrian Kochsiek, and Rainer Gemulla. Sequence-to-sequence knowledge graph completion and question an- swering. In Proceedings of the 60th Annual Meeting of the Association for Computational Linguistics, pages 2814–2828, 01 2022. doi: 10.18653/v1/2022.acl-long.201. [4] Eric Prud’hommeaux, Jose Emilio Labra Gayo, and Harold Solbrig. Shape expressions: an rdf validation and transformation language. In Proceedings of the 10th International Conference on Semantic Systems, SEM ’14, page 32–40, New York, NY, USA, 2014. Association for Computing Machinery. ISBN 9781450329279. doi: 10.1145/2660517.2660523. [5] Jorge Felpeto Cueva and Calleja Miguel Puerta. El archivo de un artesano del siglo XIV: el orfebre Alfonso Fernández de Oviedo. Phd thesis, Universidad de Oviedo, 2023.


I. Motivation IV. Results & Discussion Jason N. Ott1*, Cailey B. Condit1 and Vera Schulte-Pelkum2 1University of Washington, Earth and Space Sciences, Seattle WA 2University of Colorado Boulder, Boulder CO *jasonott@uw.edu Seismic Anisotropy of Mafic Blueschists: Constraints from Exhumed Glaucophane-Rich Blueschists with Implications for the Subduction Interface Diagram of a typical subduction zone illustrating major structural features and the evolution of pressure and temperature with increasing depth. II. Materials • Samples selected from naturally deformed, mafic blueschists with variable mineralogies spanning a broad range of the blueschist facies P-T conditions. o Bandon OR: BAN09, BAN15, LAB34 o Cycladic Islands: CY106, CY107 o Diablo Range CA: DR221, DR265 o New Caledonia: LAB555, LAB570, LAB572 o Catalina Schist CA: GB15-02A • Kinematically oriented thin sections prepared (foliation normal/lineation parallel) for EBSD analysis. Blueschist sample P-T estimates from the literature overlain on metamorphic facies diagram with slab-top paths of van Keken et al. (2018). VI. Future Work • The remaining mafic blueschist samples targeted for this study will be mapped, analyzed, and integrated into the framework of this compilation study. • Synthetic receiver functions will be applied to subduction zone models using the results from this study to develop constraints applicable to imaging of blueschist-metamorphosed oceanic crust. • Deformation experiments on glaucophane samples at varying temperatures, strain rates, and initial grain sizes in combination with microstructural analysis of recovered samples will be used to link observations of naturally deformed blueschists to an experimentally determined flow law. III. Methods • We can better understand subduction zone dynamics by using exhumed subduction exposures to constrain remote geophysical observations. • Seismic anisotropy can illuminate subduction zone structure and link deep processes to their expression as geological hazards at the surface. • Understanding the range of seismic anisotropy in mafic blueschists, a key constituent of subducting slabs, will improve imaging of the subduction zone interface. The seismic anisotropy of the blueschist samples (in AVp %) as a function of fabric strength of the [100], [010], and [001] pfJ-indices of glaucophane in the samples—corresponding to the a-, b-, and c-axes respectively—displays a general increase in magnitude of anisotropy with glaucophane fabric strength. The strongest correlation between pfJ-index and AVp % occurs with the [100] direction. Misorientation to mean orientation maps of glaucophane in samples CY107 (top) and GB15-02A (bottom), representative of samples near the deepest and shallowest extents of warm slab-top paths under blueschist facies conditions. Deformation microstructures show evidence of intragranular misorientation gradients and subgrain boundary formation that suggest deformation may be facilitated by dislocation creep. The seismic anisotropy (in AVp %) of the blueschist samples displays a general increase in magnitude with increasing volumes of glaucophane in the sample. The seismic wave velocity orientations (AVp patterns) can be divided into 2 main types: 1) Fast-velocity girdle in the foliation plane with slow-velocities normal to the foliation that corresponds to a glaucophane CPO with point-maxima in the a-, b-, and c-axes, and 2) Fast-velocity direction parallel to the sample lineation with a slow-velocity girdle normal to the lineation direction corresponding to a glaucophane CPO with the c-axis oriented along the lineation and a girdle formed by the a- and b-axes. VII. Abstract and References Blueschists show strong seismic anisotropy, scaling with glaucophane volume and fabric strength. This is likely a useful tool for imaging subducting slabs with receiver functions. V. Key Takeaways • The seismic anisotropy of mafic blueschists is largely controlled by the modal percentage of the amphibol


Estimation of Under-5 Mortality by Wealth Quintile Fengqing Chao1, Danzhen You2, Jon Pedersen3, Lucia Hug2, Leontine Alkema4 1(Email: ephchf@nus.edu.sg), Saw Swee Hock School of Public Health, National University of Singapore. 2Division of Data, Research and Policy, UNICEF. 3Fafo Institute of Applied International Studies, Fafo. 4Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst. Poster 11833, Poster Session P3 – Data, Methods, and Professionalization, Population Association of America, Apr 27th 2017, Chicago Introduction Objective ▶Estimate the levels and trends of under-5 mortality rate (U5MR; probability of dying before age 5) by wealth quintile across countries from 1990 to 2015; ▶Estimate the relation between ratios of quintile-speciﬁc U5MR and the national-level U5MR (all quintiles combined); ▶Implement a reproducible statistical model; Wealth Quintiles ▶Refer to 5 equal-size birth groups with diﬀerent levels of socioeconomic status according to the wealth index assigned to each household; ▶1st wealth quintile = the poorest group; 5th wealth quintile = the richest group. Wealth Index ▶Computed based on selected questions asked in the Demographic Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS); ▶Indicator variables: any item that will reﬂect economic status: ▶Type of ﬂooring (dirt/cement/parquet)? Type of toilet (bush/ﬂush)? Has electricity? Number of members per sleeping room? etc. ▶Use principal component analysis (PCA) to assign the indicator weights, and get the weighted sum as the wealth index. Data Data Types # surveys DHS direct 208 MICS direct 17 MICS indirect 66 total 291 Table: Database for modeling. ‘Direct’: full birth history data. ‘Indirect’: summary birth history data. ▶95 countries with DHS and/or MICS survey data; ▶Each survey has 1 data point for each quintile; ▶Range of reference year: 1987 – 2011. Results 1985 1995 2005 2015 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Wealth Quintile Group 1 Quintile−specific / Total U5MR Country estimate Global expected 1985 1995 2005 2015 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Wealth Quintile Group 2 1985 1995 2005 2015 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Wealth Quintile Group 3 1985 1995 2005 2015 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Wealth Quintile Group 4 1985 1995 2005 2015 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Wealth Quintile Group 5 1985 1995 2005 2015 50 100 150 200 U5MR (deaths per 1000 livebirth) quintile−specific total 1985 1995 2005 2015 50 100 150 200 1985 1995 2005 2015 50 100 150 200 1985 1995 2005 2015 50 100 150 200 1985 1995 2005 2015 50 100 150 200 India 1985 1995 2005 2015 0.7 0.8 0.9 1.0 1.1 1.2 1.3 Wealth Quintile Group 1 Quintile−specific / Total U5MR Country estimate Global expected 1985 1995 2005 2015 0.7 0.8 0.9 1.0 1.1 1.2 1.3 Wealth Quintile Group 2 1985 1995 2005 2015 0.7 0.8 0.9 1.0 1.1 1.2 1.3 Wealth Quintile Group 3 1985 1995 2005 2015 0.7 0.8 0.9 1.0 1.1 1.2 1.3 Wealth Quintile Group 4 1985 1995 2005 2015 0.7 0.8 0.9 1.0 1.1 1.2 1.3 Wealth Quintile Group 5 1985 1995 2005 2015 100 150 200 250 300 U5MR (deaths per 1000 livebirth) quintile−specific total 1985 1995 2005 2015 100 150 200 250 300 1985 1995 2005 2015 100 150 200 250 300 1985 1995 2005 2015 100 150 200 250 300 1985 1995 2005 2015 100 150 200 250 300 Chad Model estimates and 90% CI for India and Chad. Row 1: ratio of wealth quintile-speciﬁc to national-level U5MR. Row 2: wealth quintile-speciﬁc and national-level U5MR. 0 20 40 60 80 1.0 1.5 2.0 2.5 3.0 Difference between U5MRQ1 and U5MRQ5 Ratio of U5MRQ1 to U5MRQ5 CMR CIV GHA HTI MWI MDA NAM NIC PRY ALB AZE BLZ BEN ERI GIN PSE TJK THA AFG ARM BLR BDI COL COG GAB GEO GUY MKD MDV MRT SRB SWZ SYR TUN UKR UZB ZMB AGO BGD BTN BOL BFA KHM CAF TCD COM COD DOM EGY GNQ ETH GMB GTM GNB HND IND IDN IRQ KEN KGZ LAO LSO LBR MDG MLI MNG MAR MOZ NPL NER NGA PAK PHL RWA STP SEN SLE SOM ZAF SSD SDN SUR TZA TLS TGO UGA VUT VNM YEM ZWE BRA JOR KAZ PER TUR G G G G G G South Asia CEE/CIS Sub−Saharan Africa Latin America and the Caribbean East Asia an


Pile-up rejection for AMoRE-II Yoomin Oh References: [1] K.S. Park et al, DOI:10.3389/fphy.2024.1323991. [2] G.B. Kim et al, DOI:10.1016/j.astropartphys.2017.02.009. [3] S.C. Kim et al, DOI:10.1088/1748-0221/17/07/P07034. [4] C. Augier et al, DOI:10.1103/PhysRevLett.131.162501. [5] T. Chen and C. Guestrin, DOI:10.1145/2939672.2939785. [6] V. Alenkov et al, DOI:10.1140/epjc/s10052-022-11104-3. AMoRE: 0νDBD search • Mo-100 enriched scintillation crystal. • Cryogenic detector technique (MMC). • AMoRE-II using 157 kg of Li2MoO4. • Being prepared at 1000 m underground in Yemilab [1]. • 5+ years running: mass·time exposure > 500 kg·year. • Energy resolution ~ 10 keV FWHM at Qββ=3034 keV. • Background level ≪ 2×10-4 count/keV/kg/year (ckky). • Half-life sensitivity ~ 4×1026 years at 90% CL. Pile-up background • Preference for a larger-size crystal detector to reduce the number of detector channels (~€$₩). • Random coincidence of two signals in a detector crystal volume. • Expecting the largest contribution from two 2νDBD signals. • Rate scales with the crystal size (internal~volume, external~area) and coincidence t window. • For Li2MoO4 with Φ/H=6 cm and a 500 µs coincidence time window (Δt): pile-up background rate at ROI ~ 2.2×10-4 ckky [4]. • Rejection at the analysis level is required with εrejection≳90%. 2νββ random coincidence Each total Pile-up simulation and analysis • Signal templates of Li2MoO4 detectors from R&D data: 1. Fast signal: rise-time ~ 1.9 ms, 10-90%, (Diffused surface / 20 mK / MMC thermal link to Cu-frame ❍) 2. Slow signal: rise-time ~ 5.8 ms, 10-90%, (Diffused surface / 10 mK / MMC thermal link to Cu-frame ✕) • Noise (baseline): randomly sampled from real data. • Analysis utilizing a machine learning method: gradient boosting [5]. Selected parameters for discrimination and training/evaluation data samples Pileup Single Single Pileup Pileup Single Pileup Pileup Single Single Pileup Single Pileup Pileup Single Pileup Pileup Single Pileup Pileup Single Pileup Pileup Single Pileup Pileup Single Pileup samples Butterworth bandpass filters with different cutoff frequencies Raw heat Raw light Raw heat Raw light Validation using real data: Bi-Po β-α decay • A CaMoO4 crystal detector with a high U/Th contamination in AMoRE-I [6]. 214Bi β−decay −−−−−−−−! Q=3.27 MeV 214Po (T1/2 = 164 μs) α−decay −−−−−−−−! Q=7.83 MeV ··· 212Bi β−decay −−−−−−−−! Q=1.88 MeV 212Po (T1/2 = 299 ns) α−decay −−−−−−−−! Q=8.95 MeV ··· Selection efficiency ~97% for single α events Some can be discriminated. Rejection efficiency~60% Expecting no rejection at all! Signal and noise characteristics affects pile-up rate • A faster signal and higher signal/noise preferred for less pile-up rate [2]. • Signal parameters such as size and speed (rise-/decay-time) can be tuned with: 1. temperature, 2. crystal surface condition, 3. thermal link between sensor (MMC) and Cu frame [3]. • Baseline r.m.s. can be controlled to be as small as a few keV level. Result and Discussion • Rejection efficiency for the pile-up of 2νDBD signals at ROI in 500 µs: • Better than 90% with faster signals on lower noise baselines. • Close to 80% with slower signals on higher noise baselines. • Selection efficiency for the single signal event > 95%. • Pile-up rate by 2νDBD at ROI can be suppressed down to (2–4)×10-5 ckky. • Studying the possibility for further improvements, not only for pile-up discrimination but also for more general event type classification. yoomin@ibs.re.kr Fast signal, Lower noise case


VIDEO ABSTRACTS: DO THE METRICS STACK UP? Tom Rees1, Sandra Lê2, Leigh Prevost1, and Sheelah Smith1 1PAREXEL International, Worthing, UK; 2Dove Medical Press, Macclesfield, UK Objective: Video abstracts offer a means to present results that complement the full paper. We aimed to compare video abstract views with other publication metrics in order to understand better the role they play in disseminating research findings. Research design and methods: Metrics were obtained from YouTube for all video abstracts published by the open-access publisher, Dove Medical Press. All articles with video abstracts published in four journals in different therapy areas over the period February 27, 2014, to March 19, 2015, were analyzed (average time since publication: 212 days), and compared with metrics for matched articles without video abstracts. Results: A total of 31 articles with video abstracts were identified. Average number of views per video was 364; most views came from United States, India, and United Kingdom. Males were 66% of viewers and 36% were aged 25–34 years. In our sample, video abstracts did not increase with time. Video views were weakly correlated with text abstract views (r-squared = 0.22) and with full paper views (r2 = 0.23) with around 1.5 video views per full paper view. Full views of papers with a video abstract were similar to those of papers without. Conclusions: Video abstracts are of interest to many authors and readers and complement full views. This is in line with authors’ and publication professionals’ views that publishing a video abstract increases the reach of research results and may increase downloads. UPDATED ABSTRACT • Video abstracts offer a novel means to present study results that can both complement and enrich the full published article. • Presenting results through a different medium could address the learning style preferences of a wider group. • In an accompanying poster, we present survey results that indicate high levels of interest from authors in video abstracts although concerns over impact and value were raised. INTRODUCTION • Video abstracts appear to be more popular with younger audiences. • The low correlation between video abstract, conventional abstract and full paper views suggests that they are reaching different audiences; however, video abstracts do not appear to replace or encourage full paper views. SUMMARY AND CONCLUSIONS • In this exploratory analysis, we aimed to compare video abstract views with other publication metrics in order to understand better the role that video abstracts play in disseminating research findings. OBJECTIVE RESULTS • Across the Dove Medical Press portfolio, the mean number of views per video abstract was 364. Scan QR code to download this poster Scan QR code to download any of PAREXEL’s and Dove Medical Press’ posters presented at ISMPP Acknowledgments The authors would like to acknowledge and thank PAREXEL Editorial and Creative Services for their support. 11th Annual Meeting of ISMPP; April 27–29, 2015, Arlington, VA, USA. • Aggregate viewing statistics for all video abstracts published by Dove Medical Press, an open-access publisher, were obtained from YouTube. • Four journals published by Dove Medical Press across diverse medical fields were identified: Clinical Ophthalmology, Therapeutics and Clinical Risk Management, International Journal of Chronic Obstructive Pulmonary Disease, and Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. • Metrics for all papers with video abstracts published over a 12-month period (February 27, 2014, to March 19, 2015) were obtained (including original research articles, reviews, case series, and case reports).  Views on PubMed Commons were excluded from this analysis. • For the control group we identified, for each video abstract, the article of the same type closest in publication date, but without a video abstract. • Relationships were explored using linear regression, two sample T-tests and, for


What determines the inner sizes of protoplanetary disks? I. Mendigutía1,*, P. Marcos-Arenal1,2, E. Koumpia3, R.D. Oudmaijer4, M. Vioque5,6, J. Guzmán-Díaz1, C. Wichittanakom7, W.J. de Wit3, B. Montesinos1, J.D. Ilee4 1 Centro de Astrobiología (CAB), CSIC-INTA, Madrid, Spain 2 European Space Agency, ESA-ESAC, Madrid, Spain 3 European Southern Observatory, Santiago, Chile 4 University of Leeds, UK 5Joint ALMA Observatory, Santiago, Chile 6National Radio Astronomy Observatory, Charlottesville, USA 7Thammasat University, Pathum Thani, Thailand * imendigutia@cab.inta-csic.es Background Planets form in gas and dust disks that surround young stars. Dust particles do not survive temperatures above 1000-2000 K, for which protoplanetary disks are cleared of dust close to the central stars. The size of such inner dust holes should be larger for more luminous (hotter) sources, ranging between ~ 0.01 and 20 au in optically-visible young stars. This range is critical for our understanding of planet formation, as it corresponds to the region where most exoplanets’ orbits lie1. In turn, those inner disk sizes translate to angular scales of milli-arcsecs even for the closest sources, and can be resolved mainly for intermediate-mass “Herbig Ae/Be” stars only by using near-infrared interferometry. Although previous interferometric studies have shown that there is a correlation linking the stellar luminosity of Herbig Ae/Be stars and the size of their inner dust disks, this “size-luminosity correlation” may change for early type Herbig Bes and shows considerable scatter2,3. The main physical scenarios proposed to explain the observed size-luminosity distribution are related to the presence/absence of innermost gas, different disk-to-star accretion mechanisms, or different dust disk properties as inferred from spectral energy distributions (SEDs)4,5,6. However, no general observational confirmation has been provided to date. Our goal is to identify the physical mechanism that drives the observed distribution in the size-luminosity correlation. References (see the associated paper Marcos-Arenal et al. 2021, A&A, 652, A68) Fig. 1. Example: the young star V590 Mon. (Left) GRAVITY/VLTI interferometric observables -flux (red), squared visibility (blue) and differential phase (green)- vs wavelength around the Brɣ emission line for two different VLT baselines. (Right) Continuum squared visibilities vs spatial frequency (solid dots with errorbars). The best fit is indicated with a solid line and corresponds to a Gaussian disk on top of the central star, leading to an inner dust disk radius ~ 2 au. Alternative fits corresponding to ring and uniform disk models are plotted with dashed and dot-dashed lines. XV Reunión Científica Sociedad Española de Astronomía. Tenerife. September 2022 1: http://exoplanet.eu/ 2: Monnier & Millan-Gabet. 2002, ApJ, 579, 694 Fig. 2. (Left) Size-luminosity relation where each panel emphasizes a different aspect. Top left: Herbig Ae and Herbig Be stars; the five with our new GRAVITY data are highlighted in red. Top right: the sources with strong (blue) and weak (red) accretion rates. Bottom left: the sources with spectro-interferometric measurements indicating the presence of atomic gas inside the inner dust disk (blue) and the ones without such evidence (red). Bottom right: Group I and Group II sources based on the SED shape. For all panels, triangles indicate upper and lower limits and the solid and dashed lines indicate the expected boundaries of the inner dust disk radius based on the two main accretion scenarios and innermost gas densities. (Right) Size-luminosity relation where the stars have been color-coded to indicate different distance ranges, the rest of the symbols and lines as in the left panel. disk Results 1) We have updated the size-luminosity diagram, almost doubling the number of optically visible young stars considered in previous works. 2) We find no general trend linking the presence/absence of innermost gas,


Predictive Modeling of Polymer-Derived Ceramics: Discovering Methods for the Design and Fabrication of Complex Disordered Solids Paul Rulis1 , Nathan Oyler2 , Michelle Paquette1, Ridwan Sakidja3, Jinwoo Hwang4 1. Department of Physics and Astronomy, University of Missouri - Kansas City, Kansas City MO 64110 2. Department of Chemistry, University of Missouri - Kansas City, Kansas City MO 64110 3. Department of Physics, Astronomy and Materials Science, Missouri State University, Springfield MO 65897 4. Department of Materials Science and Engineering, The Ohio State University, Columbus OH 43212 Program Objective • Toward the long-term goal of creating an integrated program for the design of complex disordered solids, this new project aims to develop a general, simulation- driven methodology for accurately recreating the atomic structure of substructure- containing amorphous solids and mapping resultant structures and properties back to fabrication conditions, ultimately enabling a computational design capability. • The work involves developing an ab initio molecular dynamics (AIMD) and hybrid reverse Monte Carlo (HRMC) simulation that is augmented by ab initio total energy and a set of geometric constraints. We will use a collection of thin-film amorphous preceramic polymers (a-BC:H, a-SiBCN:H, and a-SiCO:H) as suitably complex and technologically relevant case studies. • We develop novel algorithms for linking growth conditions and characterization information to atomistic simulation, and for mapping fabrication conditions to desired properties. Our modeling goal is to first identify non-global potential energy minima for material sub-components that are produced under non-thermodynamic conditions and to then align the timescales of the simulation and growth processes so as to generate realistic structural models of complex disordered solids. • The project combines state of the art computational techniques (AIMD, HRMC), modern optimization algorithms (e.g. artificial neural networks (ANNs), particle swarm optimization (PSO)), specialized experimental characterization techniques, (solid-state nuclear magnetic resonance (NMR), 4-dimensional scanning transmission electron microscopy (4D-STEM)), and advanced thin-film fabrication technology (plasma enhanced chemical vapor deposition (PECVD)). • The unique utility of modern solid-state NMR techniques to obtain specific bonding and connectivity information and the sensitive medium-range order information available from 4D-STEM will be combined with neutron diffraction and more routine physical/electronic structure characterization methods to provide input and constraints for the simulations. The project includes (left) growth and characterization, (middle) iterative modeling, and (right) design training and validation. Single-frame red boxes represent experimental samples and data, while double-framed blue boxes represent computational products. The shaded region in the middle represents the application of particle swarm optimization. The general flow can be understood as: (1) growth of samples varied by composition and growth procedures; (2) experimental structural characterization; (3) iterative model simulation using characterization data; (4) ANN training to link simulation and growth parameters followed by predictive application of the ANN. Acknowledgement To meet the long-term goal of developing an integrated program for the fabrication of complex disordered solids that are designed to satisfy the performance requirements of advanced applications, we set the following plans for the first year of this project. 1. We will form connections between experimental characterization and simulated data to guide the construction of realistic models of preceramic polymers. Our working procedure for generating individual models is to prepare the composition for a large-scale classical MD simulation via smaller scale AIMD and to then use HRMC to progressively improve matching between the mod


Diagrams for PhD research By Scott Skipworth ORCID: https://orcid.org/0000-0003-2674-529X Disseminated Embodiment: My term for a repositioning of human embodiment for the 21st Century: no longer a distinct figure in relation to the built environment, but an expanding and contracting satellite system of the local and global built environment itself. Diagram by Scott Skipworth ORCID: https://orcid.org/0000-0003-2674-529X Embodied student physically at site visit while meeting with studios at remotely located campuses through mobile technology: student is disseminated – in “place” across locations: Where to put one X to represent student figure in a place? (can’t) Diagram by Scott Skipworth ORCID: https://orcid.org/0000-0003-2674-529X Embodied client/user physically at home interacting with remote urban site through personal (home) and building mounted (site) technology (body sharing?)– in “place” across locations: Where to put one X to represent the user figure in a place? (can’t) Existing framework/model of human embodiment as figure in a built environment “place” no longer works Existing framework/model of human embodiment as figure in a built environment “place” no longer works


1 Unidad de Genotipado y Diagnóstico Genético (UGDG), INCLIVA, Valencia (Spain) 2 Unidad de Bioinformática, INCLIVA, Valencia (Spain) 3 Hospital Universitari de Tarragona Joan XXIII / IISPV / Universitat Rovira i Virgili / CIBERDEM (Spain) Daniel Pérez-Gil1,2, Verónica Lendínez-Tortajada1, Alba Sanchis-Juan1,2, Pilar Rentero-Garrido1, Ana Megía3, Joan Vendrell3, Felipe Javier Chaves-Martínez1, Pablo Marín-García1,2 DPMAS: pipeline for 450K top table replication with MiSeq amplicons ABSTRACT DNA methylation is one of the most important epigenetic modifications in gene expression regulation and it plays a crucial role in multiple biological processes. Therefore, DNA methylation profiling is important to reveal regions of the genome that are altered during development or that are perturbed by disease. Methylation signals at CpG sites can be assessed using bisulfite conversion method and massive sequencing technologies. Here we present the implementation of a bioinformatics pipeline for replication with MiSeq sequencing amplicons of the top hits obtained from Infinium 450K differential methylation experiments. CONCLUSIONS We have implemented a bioinformatics pipeline for replication of the top hits obtained from Infinium 450K experiments using MiSeq sequencing amplicons. For this purpose we have used well-established software for genome analysis as well as applications developed in our lab, all of them open source. The proposed workflow has proved to be useful for methylation level assessment while maintaining a good data quality control. Source code will be available at: https://github.com/pamag/DPMAS PIPELINE REPORT 450K results The assessment of methylation level at CpG sites from raw genetic sequences involves quality control and several processing steps. The main building blocks of the pipeline include SNP selection from 450K experiments, sequencing of the regions containing those SNPs with directional primers, mapping of the reads to the reference amplicon sequences and variant calling at cytosines in CpG sites. Finally, a dashboard report is produced as an analysis summary. Other SNP selection Directional amplification primers design MiSeq sequencing Adaptor removal and quality trimming Mapping Min length filter Calling C and T counts REPORT Beta values plot FASTQ BAM VCF Figure 2. Coverage plot. Depth per base distribution is plotted for each sample (black lines) in every experimental group. In this example a threshold of 100x is established as a minimum value to report reliable results (red line). Figure 3. Methylation plots. Beta values plot (A). Methylation percentages of CpG sites along the amplicon are plotted for each sample in every experimental group. The 450K selected SNPs are highlighted as a red line. In this example only those samples with coverage >=100 at the CpG site are plotted. A reliability value is assigned to each point depending on the error assumed when the methylation level is assigned (B). Figure 1. Localization plot. The region where the selected 450K SNPs are located is plotted. Chromosome and gene transcripts are displayed and the CpG of interest is shown as a red line. Table 1. Methylation level table. Mean, standard error and number of samples (mean±se(N)) are shown for each CpG site in every experimental group. The CpG site of interest is highlighted in red. Position c1 c2 c3 c4 64 77.71±0.63(46) 79.03±0.49(85) 78.69±0.61(60) 78.61±1.02(62) 105 89.76±0.37(46) 89.3±0.42(85) 90.38±0.45(60) 89.82±0.6(61) 108 94.75±0.21(46) 95.01±0.24(85) 94.62±0.24(60) 94.61±0.42(62) 119 54.15±4.57(46) 52.69±3.43(85) 55.51±4.14(60) 56.16±3.84(63) 127 95.71±0.18(46) 95.89±0.19(85) 95.82±0.28(60) 96.2±0.38(62) 187 92.49±0.46(46) 92.57±0.31(85) 92.91±0.27(60) 92.88±0.56(62) 218 96.03±0.21(46) 96.21±0.27(85) 96.3±0.23(60) 96.46±0.33(62) A) B) c1 c2 c3 c4 c1 c2 c3 c4 c1 c2 c3 c4 c1 c2 c3 c4


About the agreement To achieve the large-scale transformation towards open access, the project partners devised a “Publish and Read” (PAR) model with two components: The Projekt DEAL-Wiley agreement Significantly increased open access output from German research institutions. Enabled researchers from German institutions to easily publish their work open access, independently from available funding in their research areas, and retain copyright for their work. Expanded access to research findings for German institutions. Expand equal access to high-quality scholarly journals to all researchers in Germany. Analysis Wiley and the project partners are constantly monitoring the publishing output. Now that the agreement has been in effect for over two years,what are the actual changes in publishing and reading behaviour Wiley was able to observe? After the second year of this agreement, it is possible to draw the reasonable conclusions about impact and achievements: The two Key goals of the Projekt DEAL-Wiley agreement: Transitioning to an open future Wiley’s commitment to open access Empower all (corresponding) authors with the means to publish their articles openly. Gold Open Access increase in the number of Gold journal published articles from 2018 to 2020. increase the number of accepted and approved articles in 2020, compared to 2019. Hybrid Open Access increase in the number of articles published open access. of authors choose to publish OA in our journals of authors choose a CCBY license Open Access Publishing The Projekt DEAL-Wiley agreement has already made notable advancement towards a higher ratio of open access publications. articles published in Wiley’s hybrid portfolio between July 2019 and December 2020. articles published in Wiley’s Gold Open Access journals in 2019 and 2020. Outcomes: Reading accesses to full text HTML and PDF (2020). increase in usage since before the agreement. Participation and reach institutions where Readers have reading rights (2020). Publish component: • Authors publishing in Wiley’s 1,400+ hybrid journals may publish OA at no direct cost to them; Projekt DEAL pays a PAR fee of 2.750€ to Wiley per such article • Authors can publish in 230+ fully gold open access journals at no direct cost*, and institutions get a 20% discount on the Article Publication Charge (APC). Read component: • Participating institutions gain free read access to more than 1,600 Wiley journals (dating back to 1997) Outcomes: Introduction In January 2019, Projekt DEAL, a consortium representing German research institutes and academic libraries, signed a large-scale open access agreement with Wiley, publisher of over 1,600 peer-reviewed journals from all areas of research. Its goal was to accelerate the nation-wide transition from a predominantly subscription- based publishing model to one based on open access. It is intended to significantly raise the number of open access articles being published out of German research institutions while securing, and even expanding institutions’ read access to Wiley’s journal output at the same time. >1000% 92% 15,716,977 49% 495 58% 92% + 14,500 + 1,500 Participation and reach institutions where eligible authors have open access publishing rights. (2020) 943 Conclusions + 50% *Some institutional funding policies may differ for gold OA APCs. Authors should check with their library for any exceptions. Authors: Melanie Lehnert-Bechle (Wiley-VCH), Torben Quasdorf (Wiley-VCH), Eva-Maria Scheer (Wiley-VCH) This work is licensed under a Creative Commons Attribution 4.0 International License.


• has attracted over 900 registered users world-wide, up from 400 users in 2013 SI2-SSE: Modules for Experiments in Stellar Astrophysics (MESA) The goal of this project is to support the MESA software infrastructure by providing sustained innovation in the astrophysics community. MESA solves the 1D fully coupled structure and composition equations governing stellar evolution with implicit ﬁnite volume scheme. State-of-the-art modules provide adaptive mesh reﬁnement, sophisticated timestep controls, non-adiabatic oscillation capabilities, equation of state, opacity, nuclear reaction rates, element diffusion, boundary conditions, and changes to the mass of the star. MESA has signiﬁcant penetration in the astrophysics community and is well on its way to becoming the world standard for evolving stars, providing a crucial resource to the astrophysical community at just the right time. The third year of our SI2-SSE award has been key to sustaining MESA as an essential piece of software infrastructure while building new scientiﬁc and educational networks. • software instrument papers MESA I (2011), MESA II (2013), and MESA III (2015) have collectively been cited over 1000 times. Each paper ranks in the Top 25 most cited astronomy and astrophysics paper published in that year. Frank Timmes (PI), Rich Townsend (Co-PI), Lars Bildsten (Co-PI), Bill Paxton (MESA’s First Author). MESA: ~300 Registered USA Users Sept. 2016 South Pacific Ocean South Atlantic Ocean North Atlantic Ocean North Pacific Ocean Indian Ocean MESA: ~915 Total Registered Users Sept. 2016 0 15 30 45 2012 2013 2014 2015 2016 Grads Postdocs Undergrads Faculty Amateurs 28% female 80% USA 66% USA 39% female 64% USA 33% female 68% USA 47% female 48% USA 32% female Citations 0 100 200 300 2011 2012 2013 2014 2015 Sept. 2016 MESA I 2011 MESA II 2013 MESA III 2015 Total Citations: 947 as of 01Sep2016 • had one paper, MESA II, that was one of 15 papers selected by the American Astronomical Society for “high-impact research” published between 2012 and 2015. MESA was publicly launched in 2011 and received an SI2-SSE award in 2013. The MESA project • has witnessed over 10,000 downloads of the source code • has distributed over 12,000 archived and searchable posts on community discussions • provides a Software Development Kit to build MESA across a variety of platforms • delivers an annual Summer School program that now has over 170 graduates which offers a week of extensive hands-on labs on how use MESA in their own research • hosts a web-portal for the community to share analysis tools and build provenance • offers a prototype of a cloud resource for education, MESA-Web, that has served up over 1500 models for education to 40 institutions in the USA unique users in its ﬁrst year of operation.


Bringing Interoperable Annotation to All Scholarly Works Annotating All Knowledge Coalition and Working Group A coalition of some of the world’s key scholarly publishers, platforms, libraries, and technology organizations are coming together to create an open, interoperable annotation layer. Web annotation is here! Our goal is to make it pervasive across scholarship, open and interoperable. For decades web pioneers have imagined a native and universal collaborative capability over the Web. Many projects have experimented with it, yet in 2015 we’re still stuck with the same patchwork of proprietary commenting systems, only available in some places. In the last few years a growing community has been working to change that. Our goal is to standardize “annotation” as a unit of conversation built into the very fabric of the Web. In late 2014 the World Wide Web Consortium (W3C), the standards body for the Web, established a formal Working Group to support this standards eﬀort. Much progress has been made, and many implementations are now mature enough to be deployed. What’s possible with web-based annotation? Make persistent annotations in texts by highlighting passages, adding notes, and tagging with keywords. Coalition Founding Members American Geophysical Union ● Amherst University Library ● Annual Reviews ● arXiv ● Atypon ● Authorea ● Biodiversity Heritage Library ● biorxiv ● Brandeis University Library ● Cambridge University Press ● CELI ● Carnegie Mellon University ● Centre for Agriculture and Biosciences ● International Center for Open Science ● Collaborative Knowledge Foundation ● ContentMine ● Crossref ● Duke University Press ● eLife ● Elsevier ● Europe PubMed Central ● Europeana ● F1000 - Faculty of 1000 ● Factminers ● Gigascience ● Harvard- Smithsonian Center for Astrophysics ● HathiTrust ● Highwire ● Hypothes.is ● IDPF ● iPython / Project Jupyter ● JHU MUSE ● Journal of Neuroscience Research ● JSTOR ● Knowledge Unlatched ● Michigan Publishing ● MIT Press ● NASA Astrophysics Data System ● NYU Press and NYU Libraries ● O’Reilly Books (aka Safari Books Online) ● PKP / Open Journal Systems ● Publishing Technology plc ● ORCID ● Oxford University Press ● PaperHive ● Pensoft ● PLOS ● Pressbooks ● RedLink ● Romanian Center for Investigative Journalism ● Semantico ● SSRN ● Stanford University Libraries ● Ubiquity Press ● University of California Davis Library ● University of California Press ● University of Illinois Libraries ● University of Southern California - Scalar ● Unizin ● W3C ● Wellcome Library ● Wiley ● Wolfram ● World Archives of Sciences ● World Digital Mathematics Library – – – – – – Goal To deploy an interoperable annotation layer over all scholarly and scientiﬁc works within three years. – Members agree to Share the vision for how this can beneﬁt scholarship Explore how to incorporate web annotation Collaborate openly with others Be open about their participation – – – – Annotating All Knowledge Coalition AAK Working Group was established at FORCE11 to support the work of the AAK Coalition. Support the communication and dissemination needs of the coalition Provide a forum for AAK Coalition discussions Coordinate technical working group Organize Face to Face meeting at FORCE2016 – – – Timeline – – – – Face to Face Kick Oﬀ Meeting >55 attendees can network Establish a working deﬁnition of interoperability Deﬁne the most compelling use cases/user stories to drive technology development Organize a technical speciﬁcations working group Discuss branding – – – – – AAK Working Group The coalition is open to any scholarly publisher, platform, library or technology organization that shares our vision and objectives and wants to participate. Contact us at: coalition@hypothes.is for more information. Join the working group at FORCE11 Contribute your use cases Contribute your talent Build open annotation into your platform – – – – Participate Upcoming events I Annotate Berlin, May 19-20, 2016 – Join us! hypothes.is/annotating-a


d matthias de Fré Jeroen van der Hooft Tim Wauters Filip De Turck how to Realize an immersive Jedi Council meeting a Capturing Story of holograms and Their hyperdrive delivery


Sample Ms Mr Bc Bcr Mr/Ms Bcr/Bc B2861 1.21 0.267 11.63 21.02 0.221 1.807 B4591 0.34 0.14 29.25 41.7 0.412 1.426 B5981 1.3 0.2 6.79 12.94 0.154 1.906 B7151 0.95 0.113 3.29 6.24 0.119 1.897 Image credit: IODP, Blastcube from wiki AF Thermal Can we use field dependence of susceptibility to identify the magnetic mineralogy of submarine basalts? Hong Yang (hyang777@Stanford.edu), Sonia M. Tikoo | Dept of Geophysics/Dept of Earth & Planetary sciences, Stanford University Dario Bilardello, Peat Solheid | Institute for Rock Magnetism, University of Minnesota IODP Expedition 391 scientists 30-second Summary Background & Motivation Sample Info χHd = (χ300 A/m -χ30 A/m)/χ30 A/m -100 x10 -3 -50 0 50 100 0.16 0.12 0.08 0.04 0.00 Bc (T) 600 400 200 0 -200 -400 -600 Am 2/T 2 Bu (T) -100 x10 -3 -50 0 50 100 0.12 0.08 0.04 0.00 Bc (T) 400 300 200 100 0 Am 2/T 2 Bu (T) -100 x10 -3 -50 0 50 100 0.12 0.08 0.04 0.00 Bc (T) 2500 2000 1500 1000 500 0 -500 Am 2/T 2 Bu (T) 𝜒= 1% 𝜒= 5% 𝜒= 51% 𝜒= 14% -100 x10 -3 -50 0 50 100 0.16 0.12 0.08 0.04 0.00 Bc (T) 600 400 200 0 -200 Am 2/T 2 Bu (T) T (℃) k (10-6 SI) k (10-6 SI) T (℃) k (10-6 SI) T (℃) k (10-6 SI) T (℃) Preliminary Conclusions Acknowledgement References heating cooling heating cooling heating cooling heating cooling To help guide the choice of demagnetization method of submarine basalts in shipboard/lab measurements, we test if room temperature field dependence can be used to infer the magnetic mineralogy of submarine basalts. We studied magnetic properties of basalts with different field dependences. We found the field dependence behavior is associated with Hopkinson peaks. High field-dependent basalts are characterized by reversible thermomagnetic curves and low Curie temperature and should be better treated with AF demagnetization. [1] Zhou W, Van der Voo R, Peacor D R, Zhang Y 2000 Earth Planet. Sci. Lett. 179 9 [2] Özdemir Ö 1987 Phys. Earth Planet. Inter. 46 184 [3] Furuta T 1993 Geophys. J. Int. 113 95 [4] Sager W, Hoernle K, Petronotis K 2020 [5] Jackson M, Moskowitz B, Rosenbaum J, Kissel C 1998 Earth Planet. Sci. Lett. 157 129 [6] Bilardello D 2023 IRM Q. 32-4 [7] Clark D A 2016 ASEG Extended Abstracts 2016 1 Field dependence data: Clark 2016 B2861 Deposit type: pillow lava Depth: 292.52m Location: (-32.32806, -0.643127) B5981 Deposit type: massive lava flow Depth: 391.32 m Location: (-32.32806, -0.643127) B4591 Deposit type: massive lava flow Depth: 174.09 m Location: (-25.202398, 7.4969) B7151 Deposit type: massive lava flow Depth: 181.92 m Location: (-25.202398, 7.4969) • Field-dependent behavior is associated with the Hopkinson peak, especially the rising part. • Real and Imaginary susceptibilities show different peak positions • The magnitude of room temperature field dependence depends on where the Hopkinson peak is, which is influenced by the Ti content of Titanomagnetite. • Samples with high field dependence is correlated with low Curie temperature and reversible k-T curve. They are better suited for AF demagnetization. • More to explore with field-frequency dependence? • We thank Institute for Rock Magnetism for awarding HY the visiting student fellowship to conduct this research. Additionally, we would like to extend our appreciation to Max Brown for his valuable assistance in arranging the visit. • The IRM is a US National Multi-user Facility supported through the Instrumentation and Facilities program of the National Science Foundation, Earth Sciences Division (NSF EAR -2153786), and by funding from the University of Minnesota.”


MATERIALS AND METHODS Biomethane gasometer Raw biogas gasometer 100L Tank Settler Biogas (G) Settled Biomass Liquid Recirculation (L) Domestic wastewater or centrate Raw biogas composition: Biogas upgrading using algal-bacterial processes in wastewater treatment plants M. Rosario Rodero1,3, Raquel Lebrero1,3, Esteban Serrano2, Enrique Lara2, Zouhayr Arbib2, Raúl Muñoz*1,3 1- Department of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n., Valladolid 47011, Spain. 2- FCC Servicios Ciudadanos, Av. del Camino de Santiago, 40, edificio 3, 4ª planta,28050 Madrid, Spain 3- Institute of Sustainable Processes, University of Valladolid, 47011, Valladolid, Spain * Author for correspondence: mutora@iq.uva.es INTRODUCTION RESULTS AND DISCUSSION CONCLUSIONS Negligible influence of the hydraulic retention time (HRT) in the HRAP and the biogas flowrate in the absorption column on the biogas upgrading performance. Higher CO2 and H2S removal efficiencies were obtained using centrate instead of domestic wastewater due to the higher alkalinity and pH of the influent. Higher L/G ratios entailed higher CO2 and H2S removals, but an increased stripping of N2 and O2 was observed, which negatively impacted CH4 concentration in the upgraded biogas. To the best of our knowledge, this work demonstrated for the first time the capacity of algal-bacterial systems for the simultaneous biogas upgrading and wastewater treatment at semi-industrial scale. References: [1] Toledo-Cervantes A., Serejo M., Blanco S., Pérez R., Lebrero R., Muñoz R., (2016). Photosynthetic biogas upgrading to bio-methane: Boosting nutrient recovery via biomass productivity control. Algal Res.17, 46-52. [2] Marín D., Posadas E., Cano P., Pérez V., Blanco S., Lebrero R. and Muñoz R. (2018). Seasonal variation of biogas upgrading coupled with digestate treatment in an outdoors pilot scale algal-bacterial photobioreactor. Bioresour. Technol. 263, 58-66 [3] Posadas, E., Serejo, M.L., Blanco, S., Pérez, R., García-Encina, P.A., Muñoz, R. (2015). Minimization of biomethane oxygen concentration during biogas upgrading in algal-bacterial photobioreactors. Algal Res. 12, 221–229. Acknowledgments:The project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 689242. Biogas, which mainly consists of CH4 (40-75%), CO2 (15-60%) and H2S (0.005-2%), constitutes a valuable renewable energy source able to reduce our current dependence on fossil fuels. In this context, H2S removal is mandatory due to its corrosive, malodorous and pernicious nature, while CO2 removal increases the specific calorific value and reduces biogas costs of compression and transportation [1]. Figure 2. Influence of the L/G ratio on biogas upgrading performance at biogas flowrate of 276 (black), 370 (white) and 459 (grey) L h-1 during stage I (a), stage II (b) and stage III (c). Effluent composition DWW, HRT= 3.5 days DWW, HRT = 8 days Centrate, HRT = 73 days COD (mg L-1) 99.4±31.3 65.0±21.7 123.8±0 N-NH4 + (mg-N L-1) 3.1±1.7 1.0±1.1 0±0 N-NO2 (mg-N L-1) 0.8±0.5 0.4±0.2 13.3±11.7 N-NO3 (mg-N L-1) 2.0±1.2 9.6±0.5 38.1±7.4 P-PO4 3- (mg L-1) 1.0±0.5 1.3±0.3 19.9±5.4 Figure 3. Wastewater removal efficiencies in the high rate algal pond during stage I (white), II (black) and III (grey) Table 2. Effluent composition under steady state conditions Objetive: To assess the influence on biomethane composition of: L/G ratio: 1.2, 2.1 and 3.5 Biogas flow rate (G): 274, 370 and 459 L h-1 Parameter Stage I II III Type of wastewater DWW DWW Centrate HRT (d) 3.5 8 73 Average temperature (°C) 23.5±2.5 12.4±2.3 18.8±3.0 Average pH in the cultivation broth 7.3±0.2 7.1±0.5 8.9±0.3 Figure 1. Schematic diagram (left) and photograph (right) of the continuous biogas upgrading experimental plant at Aqualia’s facility in Chiclana CH4 (%) 69.2±4.9 CO2 (%) 32.7±2.8 H2S (ppm) 1183±1006 Biogas upgrading in algal–bacterial photobioreactors re


9668 экземпляров жужелиц 2576 экземпляров мертвоедов 1446 находок отдельных видов 89 точек сбора материала Со времени подписания международной конвенции о биологическом разнообразии и разработки национальной стратегии по сохранению биоразнообра- зия в России прошло почти 30 лет. Многое было сделано в практическом плане этой области за последние годы (образование ООПТ). Однако, как можно пытаться сохранить то, что еще не полностью изучено? В Респуб- лике Татарстан да и в других соседних регионах вопросами биоразнообразия занимаются считанные диницы. Отсутствуют видовые списки для многих таксо- Недавно в GBIF были опубликованы 4 датасета от ИПЭН АН РТ, включающих более 1400 индивидуальных встреч видов жесткокрылых (рис. 1). В результате, на тер- ритории Европейской России появились виды жужелиц, ко- торые ранее там были единично отмечены в соответствии с сайтом (рис. 2). При этом на территории Европы эти виды порой представлены тысячами находок. Многие эти виды на самом деле имеют довольно широкое распро- странение на территории России, однако данные об этом приходится собирать из многочисленных литературных источников. Опыт внесения архивных данных по биоразнообразию беспозвоночных в GBIF Большую помощь в этом могут оказать электронные базы данных. Одним из таких ресурсов является GBIF, который бывает чрезвычайно полезен в некоторых случаях при обработке данных. За последние годы интерес к этому ресурсу в России значительно возрос, организуют семинары и конферен- ции. В прошлом году к GBIF присоединились десятки ООПТ и других организаций России. В Республике Татарстан это Волжско-Камский Заповедник. Для составления первой базы данных в GBIF, нами были взяты данные по распределению двух семейств Жесткокрылых (Жужелицы и Мертвоеды) в Волжско- Камском заповеднике, где исследования охватывают пе- риод с 2014 по 2019 гг. и в новом заказнике «Волжские просторы». Сборы из почвенных ловушек охватили около 12000 экз. Жуков определяли в лабораторных условиях, проверку определения некоторых видов проводили в Москве. В заповеднике исследованиями были охвачены 26 биотопов, на островах – 53. Таблицы приведены в соответствие с требованиями базы данных. Помимо внесения недавно полученных данных, в GBIF есть возможность публикации данных из литературных источников, а также архивных записей и коллекций. Лаборатория биомониторинга ИПЭН располагает обширной коллекцией сборов, начиная с 1910-х годов. Проводится активная работа по определению и систематизации материала, собранного не только в Республике Татарстан, но и в соседних регионах, многими энтомологами (Алейникова, 1964, 1979, Утробина, 1956, Жеребцов, 2000). Д.Н. Вавилов Институт проблем экологии и недропользования АН РТ, Казань sabantsev.ipen@gmail.com Результаты Рис. 1. Встречи жуков жужелиц и мертвоедов в исследуемом регионе до и после внесения данных в GBIF Рис. 2. Находки вида Paradromius linearis (G. A. Olivier, 1795) на терри- тории Европы и России


DOIs Should Not Link to Data In August of 2011, the National Academy of Science’s Board of Research Data and Information (BRDI) had a meeting on the topic of “Developing Data Attribution and Citation Practices and Standards”. As part of that meeting were various breakout groups to discuss issues that still remained regarding technical, scientific, and socio-cultural issues, the roles and actors that needed to be involved, and how to get additional feedback from the community. The technical breakout group decided that the majority of the technical problems with citing data revolved around establishing the identity of what it was that we were attempting to cite. As such, our recommendations were to push some of the work back onto the data publishers to tell us how scientists should cite their data (to avoid different disciplines applying different rules), establish ‘data landing pages’ to describe, document and link to the data, and to provide those pages with persistent identifiers such as a DOI. We present here some of the reasons that were discussed about why not to link directly to data, including: recalibration, reaccessioning and other data impermanence, setting context and providing links to documentation, and allowing selection of different packaging formats http://virtualsolar.org/ IN13B-1564 J.A. Hourclé NASA-GSFC (Wyle) joseph.a.hourcle@nasa.gov Data Impermanence: Recalibration / Versioning New processed forms of data create a slightly different problem from outright removal; as one form of the data is deprecated, a new form supersedes it Some projects will generate new calibrations of the data as the sensor degredation is better understood without a fixed release. Some data is released in near-real-time, with a reprocessing pass done after additional calibration tests are run. In the case of NASA’s Solar Dynamics Observatory’s (SDO) Atmospheric Imaging Assembly (AIA), data is available immediately after downlink, reprocessed 4 days later, then again 6 months later, each time improving the precision of the resultant data. Multiple calibrations of the same observation from SOHO/EIT For long-lived projects, the data is not fixed until after the data gathering concludes. The joint NASA/ESA Solar and Heliophysics Observatory (SOHO) was launched on December 2, 1995, with instruments that have been collecting data for almost 18 years and have not generated a ‘final data product’. Once these better calibrations are available, the older data is obsolete and, in some fields, discarded. Due to a lack of data citation standards, there is no easy way to identify which versions may have been used as part of the scientific record and should be maintaned long-term. Keeping all editions of the data is not cost-effective, and so only the raw data and ‘final data product’ are archived for the long-term. If people attempt to link to data that has been superseded, the archive has a few choices: Return the original data (or the replacement) We don’t know why someone was following the link: are they doing new research or trying to validate older work? Replacements may be suitable if your identifiers are for the observations (as is done in some Active Archives), but typically DOIs are used for objects with a fixed form and this would not be expected. Redirect to the replacement. This will give a clue that a replacement has been made, but most browsers and automated user agents will redirect without any indication that they did so. Return a message explaining what’s happened. Automated agents may not realize what’s happening. If served as a success (HTTP 200), they may assume it’s the data requested. If served as common redirections (HTTP 301 to 307), most user agents will redirect without displaying the message. HTTP 300 (Multiple Choices) without a Location header is your best option. You need a response is over 1024 bytes to avoid browser rewriting. Data Impermanence: Deaccessioning / Removal If data isn’t actively used by the designated


The highly contagious SARS-CoV-2 virus has generated an unprecedented pandemic with global dramatic public health and socio-economic consequences. Despite the progression of the global use of efficient vaccines, an increased transmissibility of variants of concern (VOC) is predominantly observed. Besides effective vaccination campaigns and new approved antivirals, hundreds of thousand patients have still been admitted to ICU in Europe in the first half of 2022. Passive immunotherapies based on monoclonal antibodies have shown a drop of neutralization potency against VoCs. A polyclonal approach might be effective to neutralize fast-evolving VoCs and prevent worsening medical conditions for hospitalized patients at risks. The main objective of the European EPIC-CROWN-2 consortium is to rapidly assess, in multicentric clinical trials (phase IIa/b) an EMA-authorized antiviral immunotherapy based on potent and broad equine neutralizing anti-SARS-CoV-2 polyclonal F(ab’)2 antibodies in COVID-19 patients, including VOC carriers. Production of equine neutralizing anti-SARS- CoV-2 polyclonal F(ab’)2 antibodies Phase 2a cohort 1: Patient’s enrolment completion Validation of the Safety profile of FBR-002 by the DSMB Phase 2a cohort 2: Ongoing patients' enrolment Belledant A.¹, Luczkowiak J.³, Delgado R.³, Rodriguez E.⁴ , Veas F.⁵, Giamarellos-Bourboulis E.², Herbreteau C.H.¹* ¹FAB’ENTECH (Lyon, France), ²HISS Hellenic Institute for the Study of Sepsis, Athens, Greece, ³IMAS12, Instituto de Investigación Hospital Universitario 12 de Octubre (Madrid, Spain), ⁴BNITM, Bernhard Nocht Institute for Tropical Medicine (Hamburg, Germany), ⁵IRD, Institute of Research and Development (Montpellier, France) *Corresponding Author: scientific.communication@fabentech.com Luczkowiak J, Radreau P, Nguyen L, Labiod N, Lasala F, Veas F, Herbreteau C.H, Delgado R. Potent Neutralizing Activity of Polyclonal Equine Antibodiesagainst SARS-CoV-2 Variants of Concern. J Infect Dis. 2022. DOI: 10.1093/infdis/jiac331 Table . Neutralizing Levels for FBR-002 Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Authentic Clinical Isolates, SARS-CoV-2 Pseudotyped Particles, and Controls and Median Inhibitory Concentrations With Sotrovimaba FBR-002 exhibits significant neutralizing activity against current described VoCs including Omicron subvariants BA.4/5 FBR-002 neutralizing potency x100 as compared in humans after COVID-19 mRNA vaccines FBR-002 neutralizing activity more resilient against VoC than clinically approved mAbs Highly purified polyclonal F(ab')2 fragments Based on a technology developed by Sanofi Pasteur and licensed to Fabentech Standard production process FAB’ENTECH PLATFORM EPIC CROWN-2 CLINICAL TRIAL PROJECT EQUINE POLYCLONAL ANTIBODIES IMMUNOTHERAPY AGAINST COVID-19/SARS-COV2–VOC IN VITRO STUDIES : SARS-COV-2 NEUTRALIZING ASSAYS OF FBR-002 EVOLUTION OF SARS-COV-2 VOC NEUTRALIZING LEVELS METHODOLOGY NEUTRALIZATION OF SARS-COV-2 VOC (FBR-002) KEY STATEMENTS CLINICAL BATCH OF FBR-002 PRODUCTION VALIDATED HIGH NEUTRALIZING POTENCY OF FBR-002 TO SARS COV-2 VOCS IN VIVO EFFICACY OF FBR-002 ONGOING SAFETY PROFILE OF FBR-002 UNDER EVALUATION IN PHASE 2A CLINICAL TRIAL


Safe-, sUstainable- and Recyclable-by design Polymeric systems A guidance towardS next generation of plasticS Simon Clavaguera1 on behalf of the SURPASS consortium 1 Université Grenoble Alpes, CEA LITEN, DTNM, 17 rue des Martyrs 38000 Grenoble, France Background, Motivation and Objectives Concept, Methodology and Implementation simon.clavaguera@cea.fr Project funded by the European Union under the Horizon Europe work programme grant agreement N° 101057901. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. Acknowledgements and funding information 1. Develop SSRbD alternatives with no potentially hazardous additives through industrially relevant case-studies (TRL3-5) targeting the three sectors representing 70% of the European plastic demand: - Building: bio-sourced polyurethane resins with enhanced vitrimer properties to replace PVC for window frames (≥ 40% carbon footprint reduction) - Transport: lightweight, therefore less energy-consuming epoxy-vitrimer (≥30% carbon footprint reduction), as alternative to metal for the train structure, anticipating emerging use of non-recyclable composites. - Packaging: MultiNanoLayered films involving no compatibilizers to replace currently non-recyclable multi-layers films (≥60% carbon footprint reduction). Plastic waste outlive us on this planet as they take centuries to break down. The hazard of endocrine disruption by leached substances, fast growing and pollution of land, air and water as well as greenhouse gas emissions are only some of the adverse effects of plastic waste on public and environmental health. Still, 70% of plastic waste collected in Europe is landfilled or incinerated. The overall objective of SURPASS project is to lead by example the transition towards more Safe, Sustainable and Recyclable by Design (SSRbD) polymeric materials. The SURPASS consortium will: 2. Optimize reprocessing technologies adapted to the new SSRbD systems to support achievement of ambitious recyclability targets. 3. Develop a scoring-based assessment that will guide material designers, formulators and recyclers to design SSRbD polymeric materials, operating over the plastic’s entire life cycle, including hazard, health, environmental and economic assessment. 4. Merge all data and relevant methodologies in a digital infrastructure, offering an open-access user-friendly interface for innovators. Consortium 1. CEA: Commissariat à l’Energie Atomique et aux Energies Alternatives, France 2. IPC: Centre Technique Industriel de la Plasturgie et des Composites, France 3. CIDETEC: Fundacion CIDETEC, Spain 4. LEITAT: Acondicionamiento Tarrasense Associacion, Spain 5. INDRESMAT: Indresmat SL, Spain 6. UGA: Universite Grenoble Alpes, France 7. GEONARDO LTD: Geonardo Environmental Technologies Ltd, Hungary 8. BASF SE: BASF SE, Germany 9. RIVM: Rijksinstituut voor Volksgezondheid en Milieu, Netherlands 10. UNE: Asociacion Espanola de Normalizacion, Spain 11. FhG ICT: Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung EV, Germany 12. WIPAK: WIPAK Gryspeert SAS, France 13. WFO: Waste Free Oceans Europe, Belgium The SURPASS consortium of 13 partners consisting of research and technology organizations and industries will in particular address its results to SMEs, representing more than 99% of enterprises, and therefore has an outstanding potential to contribute to the transition towards green economy


Orphan medicines legislation General pharmaceutical legislation 7 May - 30 July 2021 28 Sept. - 21 Dec. 2021 303 answers including 12 public authorities from 9 Member States* 478 answers including 31 public authorities from 15 Member States** IMPROVING ACCESS TO INNOVATIVE MEDICINES: IMPROVING ACCESS TO INNOVATIVE MEDICINES: PROPOSALS FROM NATIONAL AUTHORITIES PROPOSALS FROM NATIONAL AUTHORITIES TO REVISE THE EUROPEAN LEGISLATION TO REVISE THE EUROPEAN LEGISLATION A u r é l i e M a h a l a t c h i m y [ 1 ] , F l o r e n c e L a n s o n [ 2 ] , B l a n k a B a r t o s [ 3 ] , F l o r e n c e T a b o u l e t [ 4 ] MAIN PROPOSALS FROM NATIONAL AUTHORITIES Proportionate to the level of UMN (e.g. variable duration of market exclusivity) Focused on neglected therapeutic areas Conditional to certain obligations Be transparent on R&D costs and actual prices Launch in all or most Member States UMN re-evaluated after commercialization Use experiences developped from covid-19 crisis Joint procurement Flexibility in clinical trials conduct On the incentives granted to sponsors On the criteria for orphan designation To be adjusted to avoid "salami slicing" (segmenting therapeutic indications) To be taken into account with the severity of the disease (level of unmet medical need - UMN) Prevalence : < 5 in 10,000 persons in the EU To be clarified and graduated Significant benefit : no EU satisfactory method of diagnosis, prevention or treatment, or drug significant benefit Many isolated proposals : difficult to identify a consensus among the authorities Request of better cooperation between all agencies and more EMA support BUT emphasis on respecting the EU and Member States competences sharing > Orphan single status transformed into a mosaic of statuses Complexities : how to quantify ? which indicators ? > Future EU considerations of national authorities proposals and answers from other respondents ? Patient access to medicines Health systems sustainability Innovation support EU legislation Objectives to be balanced 80% of rare diseases are of genetic origin in the EU = Many advanced therapies have obtained the orphan medicine status under European regulation (EC) n° 141/2000 of 16 December 1999 on orphan medicial products Provides orphan designation and incentives (market exclusivity for 10 years) Ensure the relevance of incentives granted to industry (to avoid abuses) Reward risk-taking and innovation more Improve equitable patient access in the EU Needs to be revised. Why? Public consultations on revision of European legislation DISCUSSION AND CONCLUSION [1] Permanent Researcher in law at the French National Centre for Scientific Research (CNRS, research fellow), Law Faculty, UMR 7318 International, Comparative and European law (DICE) CERIC, CNRS, Aix Marseille University, Toulon University, Pau & Pays de l’Adour University, Aix-en-Provence, 13628, France. ; [2] CERPOP (Center for Epidemiology and Research in POPulation health), UMR 1295 Inserm, University of Paul Sabatier- Toulouse 3, Toulouse, 31062, France. ; [3] PhD Student in law, CREDIMI, University of Burgundy, Dijon, 27877, France. ; [4] Professor in Pharmaceutical Law and Health Economics, CERPOP, UMR 1295 Inserm, University of Paul Sabatier- Toulouse 3, Toulouse, 31062, France. Acknowledgement: This work has been supported by ANR-funded I-BioLex project (ANR-20-CE26-0007-01, coord. A. Mahalatchimy). *AT, DE, DK, ES, FI, FR, HU, NL, SE ; **AT, BE, CZ, DE, DK, EE, ES, FI, FR, HU, IS, MT, NL, PT, SE