HIP 102152b: A low-mass planet candidate around an old solar twin Thiago Ferreira & Jorge Meléndez Instituto de Astronomia, Geofísica e Ciências Atmosféricas, Universidade de São Paulo – Brazil Contact: tfsantos@usp.br ABOUT THE STAR HIP 102152 is a solar twin (Teﬀ= 5718 K, [Fe/H] = -0.016, and log g = 4.325; [1]), placed near the end of the main sequence (t = 8.2 Gyr), and presents a rotation period of 35.7 days [2]. Due to its severe lithium depletion [3], and low activity levels (log R′ HK = −5.12) but high radial velocity (RV) RMS, it was identiﬁed as a promising planet-hosting system [4]. DATA ANALYSIS HIP 102152 was observed with the ESO/HARPS spectrograph mounted at the 3.6–m telescope in La Silla Observatory between Oct.–2011 and May–2019. From a Lomb-Scargle analysis, we detected a periodic signal of ∼23–d in the RV time-series, and besides known stellar activity, no modulation of the indicators was observed at this period, nor correlations with the RVs (see Figs. 1 and 2). We employed a joint Keplerian plus Gaussian Process (GP) model and estimated the signiﬁcance of the results via Markov chain sampling, where observations at two different epochs are correlated via the kernel Σij = η2 1·exp  −|ti −tj| 2 · η22 − 2 · sin2 ( π·|ti−tj|) η3 ) η24  , a function of the Doppler amplitude of the signal (η1), the time-scale for growth and decay of active regions (which is often comparable to the star’s rotation period, η2), the recurrence time-scale for active regions (η3), and a smoothing parameter (η4) [5]. For the Keplerian orbits, both the eccentricity (in the orthogonal basis with the periastron argument: √e sin(ω) and √e cos(ω)) and the radial velocity slope ( ˙γ) were set to freely vary, and we included separated jitter parameters for data taken before and after the ESO/HARPS upgrade in mid-2015. The other model variables include the GLS orbital period (P), its Doppler amplitude (K) and a reference time (Tc). 0.0 0.1 0.2 RV RV Prot = 35.7 d Porb = 22.9 d 0.0 0.1 0.2 BIS CCF BIS 0.0 0.1 0.2 FWHM CCF FWHM 0.0 0.1 0.2 S Ca II S (H+K) 0.0 0.1 0.2 H H 0.0 0.1 0.2 H H 0.0 0.1 0.2 0.3 H H 0.0 0.1 0.2 H H 0.0 0.1 0.2 H H 10 4 10 3 10 2 10 1 100 Frequencies / d 1 0.0 0.5 1.0 S. W. Spectral Window Figure 1. GLS periodogram of the RV and activity indicators of HIP 102151. The central blue line marks the star’s rotational period and its harmonics. The green line marks the planet’s orbital period, and the red line is the periodogram peak for each variable. The power level for which FAP levels are less than 1% and 5% are indicated as grey horizontal lines. 20 15 10 5 0 5 Bisector span / m s 1 p = -0.27 50 40 30 20 10 0 10 20 30 FWHM / m s 1 p = 0.13 0.10 0.11 0.12 0.13 0.14 0.15 0.16 Ca II S (H+K) p = 0.06 0.092 0.094 0.096 0.098 H p = 0.13 0.102 0.104 0.106 0.108 0.110 H p = -0.11 0.110 0.115 0.120 0.125 0.130 H p = -0.11 7.5 5.0 2.5 0.0 2.5 5.0 7.5 Radial Velocity / m s 1 0.125 0.130 0.135 0.140 0.145 0.150 H p = 0.17 7.5 5.0 2.5 0.0 2.5 5.0 7.5 Radial Velocity / m s 1 0.12 0.13 0.14 0.15 0.16 0.17 0.18 0.19 H p = 0.11 Figure 2. The blue line represents the best-ﬁt linear correlation between the RVs and several activity indicators. The Pearson correlation test p is indicated to quantify the signiﬁcance of the correlations. RESULTS HIP 102152b is consistent with a mini- Neptune (m sin(i) = 8 ± 1M⊕) on a circular orbit with period P = 22.9 ± 0.01– d, and no RV slope was observed due to acceleration from an outer massive companion in this system (see Fig. 3). The best-ﬁt solution (by combining Normal and Jeffrey priors) was obtained with the RadVel routine [6], implementing a maximum a posteriori optimisation and computing conﬁdence intervals from 1000 independent draws plus requiring a Gelman-Rubin statistics ˆR < 1.01. π(Vr|Θ) ∝N(P|22.9, 0.01) × N(K|2, 0.2) × N(T0|x(max y), 0.01) × J (η1|0.01, 100) × N(η2|35.7, 1.4) × N(η3|30, 0.7) × N(η4|0.46, 0.01) × N(σA,B|0, 0.1) Four models (circular and eccentric, with and w/ sl


The 5GinFIRE platform A testbed for end-to-end 5G experimentation Christos Tranoris, Spyros Denazis University of Patras Patras, Greece tranoris@ece.upatras.gr, sdean@upatras.gr Anastasius Gavras, Halid Hrasnica Eurescom GmbH Heidelberg, Germany gavras@eurescom.eu, hrasnica@eurescom.eu Abstract — 5G is the next generation networking infrastructure with a strong focus on requirements of various vertical domains. 5G brings improvements on networking performance but also introduces new services for deploying software involving networking aspects in an end-to-end manner from the edge to the cloud. 5GinFIRE is an EU H2020 project that builds and operates an Open 5G NFV based reference ecosystem of experimental facilities. It enables 5G NFV-based architectures for vertical industries’ applications and facilitates experimentation. Keywords—5G; experimentation; NFV; MANO; I. INTRODUCTION The 5G system has the ambition of responding to the widest range of services and applications in the history of mobile and wireless communications [1]. Addressing the question of how a platform can host and integrate verticals and concurrently deal with reconciling their competing and opposing requirements, requires operational 5G infrastructures that can host various vertical industries’ applications. A key issue is the lifecycle management of the verticals’ services by means of Virtualized Network Functions (VNF) deployment and programmability techniques. The technical objective of 5GINFIRE is to build and operate an Open, and Extensible 5G NFV-based reference ecosystem of experimental facilities that lays down the foundations of a standards-based network substrate for instantiating fully softwarised architectures for vertical industries purposes. II. ARCHITECTURE AND IMPLEMENTATION A. Use cases and requirements 5GINFIRE (https://5ginfire.eu/) derives its requirements from a set of simple use cases that are positioned in the areas of the automotive vertical sector and smart cities. The use cases are used as source of requirements for building the infrastructure and to showcase its capabilities. In the automotive case the requirements are extracted from scenarios such as sensing-based and video-camera-based assisted driving, which use a multitude of information sources (intra- vehicle, as well as inter-vehicle and vehicle-to-infrastructure) to enable assisted driving. In the smart cities case the requirements are derived from the scenarios to facilitate the use and exploitation of available open data provided by existing sensor deployments in cities, as well as interfacing with the capabilities of the existing deployments of sensor functionality in the testbeds of the project partners in Bristol (U.K.), Aveiro (Portugal) in Europe and São Paulo and Uberlândia in Brazil. B. Arhitecture Fig. 1 illustrates the 5GINFIRE conceptual architecture derived from the ETSI NFV reference architecture [2] and upstream open source projects. It depicts the major architectural areas and shows in a workflow manner the various interactions. Although not exhaustive, the conceptual architecture highlights the functionality that is required to integrate existing open source components and physical infrastructures or being developed by the project. It provides an indication on how the required architectural and technological convergence with mainstream industrial and open source activities could be achieved. In Fig. 1 an application is composed of services that are configured to offer this application. These services are further decomposed into virtual networking and vertical functions (VxFs) that are deployed at the corresponding points of presence in the infrastructure. A use case from the automotive vertical is used to validate the platform. Following similar practices more types of virtual experimentation environments may be instantiated. The 5GINFIRE middleware communicates with the endpoints of the orchestration services that are responsible for orchestrating the man


Many projected impacts on global fisheries. Coastal artisanal fisheries are especially vulnerable • Small boats means fishers have limited ability to move with the fish • Limited to the coastal region • Limited resources to change gear • Strongly impacted by coastal upwelling and coastal hypoxia The impacts of climate change are exacerbated by a disparity in available resources 10 Days of Biriyani and Coding: Building Bridges for Indian Ocean Rim Marine Scientists Across the “Big Data Geoscience” and Cloud–computing Divide Elizabeth E Holmes1, Aditi Modi2, Kumar Nimit3, Smitha B R4, Swarnali Majumder3, Sourav Maity3,5 and TVS Udaya Bhaskar3 (1)NOAA Northwest Fisheries Science Center, Seattle, United States, (2)Indian Institute of Tropical Meteorology, Pune India, Indian Institute of Technology Bombay, India, Pune, India, (3)Indian National Center for Ocean Information Services, Hyderabad, India, (4)Centre for Marine Living Resources and Ecology, Ministry of Earth Sciences, Kochi, India, (5) Coastal Observatory and Outreach Centre, Vidyasagar University, Midnapore, India First event of the UN Decade of the Ocean capacity development initiative “Devising Early-Career Capacity Development - Indian Ocean” Report on the ITCOocean machine learning and species distribution course and hackweek Indian Ocean Coastal communities depend on fisheries for food and livelihoods The disparity extends to Indian Ocean Rim scientists – the people who will lead the science and innovations. Early career scientists are missing out a crucial area of advancement in earth sciences in the era of “big data” --- training in the new cloud-optimized geospatial tools and platforms. Ocean climate change is here and will continue Image shows increase in Ocean Heat Content relative to 1981-2010 base line Cheng, L. J., and Coauthors, 2021: Upper ocean temperatures hit record high in 2020. Adv. Atmos. Sci., 38(4), 523−530 60 ocean scientists from across India & Bangladesh Experiential Learning Lessons Learned • Visas were a major barrier for African invitees. Hold local workshops in E Africa. • Internet speed! Test everything on slow internet. • Travel cost is a barrier for participants. • Need a more coders. The few coders were stretched thin. IDEATION PITCHING TEAMWORK PRESENTATION Thank you to the ITCOocean Hack2week supporters


Efficient susceptibility screening of submarine basalts for paleomagnetic research Hong Yang (hyang777@stanford.edu), Sonia M. Tikoo | Stanford Univ. Claire Carvallo | IMPMC, Sorbonne Univ. Dario Bilardello, Peter Solheid | IRM, U of Minnesota Kevin M. Gaastra, William W. Sager, Sriharsha Thoram | Univ. of Houston IODP 391 Scientists (scan the QR code for full list) We use amplitude-dependent magnetic susceptibility to pre-screen basalt samples and select the most effective demagnetization method. Our method is as quick as two minutes per sample and non-destructive to the magnetic information in the sample. Image credit: IODP, Blastcube from wiki Alternating Field (AF) Thermal B7151, AD = 53% B5981, AD = 14% B4591, AD = 5% B2861, AD = 1% Thermal Thermal Thermal AF AF AF AF A B C D unit = 5×10-4 Am2kg-1 unit = 1×10-3 Am2kg-1 unit = 2×10-4 Am2kg-1 unit = 2×10-4 Am2kg-1 unit = 5×10-4 Am2kg-1 East Up, North East Up, North Up, North Up, North East East East East East East Up, North Up, North Up, North Up, North AF χ χ χ χ Selecting a demagnetization method requires information of individual sample’s magnetic properties: • Curie temperature • Thermal stability • Magnetic coercivity • AF field response Susceptibility amplitude dependence of Fe-Ti-O minerals can correlate well with these properties We measured the the amplitude dependence of magnetic susceptibility and use it to test on Expedition 391 basalt samples with a variety of: • Oxidation states (degree of weathering) • Emplacement types • Titanium content Amplitude dependence is well correlated with Ti content and freshness of the Ti-magnetite in the basalt, regardless of the mineral content. • High slope corresponds to low saturation magnetization values, which indicates high Ti content • Lower slope means either lower Ti content or alteration due to weathering. Amplitude-dependent • Reversible k-T curve • Low Curie temperature Amplitude-independent • Thermal instability (indicating maghemitization) • Formation of nearly stoichiometric magnetite during heating • High-AD sample (A) is characterized by low coercivity, most of its magnetization lost after 7-10 mT. • Low-AD samples (C,D) are affected by alteration and their thermal demagnetization results can be noisy • Intermediate-AD sample (B) performs well in both thermal and AF treatments. Amplitude dependence of basalt samples in this study Acknowledgement: This research used samples and data provided by the International Ocean Discovery Program (IODP) and the JOIDES Resolution Science Operator. Funding was provided by NSF, an IRM visiting student fellowship, and the USSSP. Amplitude dependence is correlated with thermomagnetic behaviors. Motivation During IODP Expedition 391, 20%-40% of shipboard demagnetization experiments on submarine basalts failed. Can we save time and resources by pre-screening samples to select the best demagnetization method? Proposed Method Amplitude dependence can differentiate fresh high Ti basalts from other samples. Amplitude dependence can help us choose the demagnetization method. Amplitude dependence (AD) = (χ300A/m- χ30A/m)/(χ30 A/m)


DataHub Team at ELIXIR Belgium datahub@elixir-belgium.org Efficient metadata collection is vital for the discoverability and reusability of experimental data. Metadata collected following standardized, structured models, and machine-readable formats enhances (meta)data interoperability and prepare the data for seamless integration with ML/AI applications. However, existing open-source tools catering to this process are limited, lacking user-friendliness, and often too specific to certain use cases. With the development of the DataHub platform, our aim is to empower researchers and institutes by offering a streamlined, intuitive, and FAIR-by-design approach to metadata management. Flora D’Anna1, Kevin De Pelseneer1 , Rafael Andrade Buono1, SciLifeLab team2, FAIRDOM community3, Frederik Coppens1. 1 VIB Data Core, VIB Technologies, Technologiepark 75, 9052 Ghent, Belgium; 2 SciLifeLab-Data Centre, SciLifeLab, Tomtebodavägen 23, 171 65 Solna, Sweden; 3 https://fair-dom.org/people. How to structure experimental metadata in DataHub Investigation: overall goals of related studies Stream of Assays: test producing measurements via 1 technology type Study: information about - the subjects or observation units under study (sources) - the samples collection protocol - the resulting samples Sample: input material of assay Protocol 1: extraction Extract: output material from protocol 1 Protocol 2: library construction Library: output material from protocol 2 Data file: outputs from protocol 3 Protocol 3: sequencing Assay: one experimental step Assay 1 Assay 2 Assay 3 Sample collection (Protocol) Samples (Material) Sources (Material) Mass Spectrometry Sequencing DataHub platform Rationale of the approach: FAIR experimental metadata by-design by starting with the end in mind DataHub aims to integrate metadata required by public or local data repositories and archives (1). This will allow researchers to collect experimental metadata according to standards from the start of their experiments, one step at the time, while referencing data files stored in appropriate data storage systems (2). Structured and standardized metadata could then be easily deposited in data repositories by researchers (3). End-repositories ●End-repositories’ checklists, ontologies, controlled vocabularies ●Sample-level metadata ●Template customisation ●Describe 1 experimental step at the time ●Link to external data storage Local archive Streamlined metadata and data submission to end-repositories End-repositories’ metadata requirements and standards Collection of experimental metadata 1 2 3 https://datahub.elixir-belgium.org ELNs Object storage Future developments https://datahub-test.elixir-belgium.org • For active (meta)data collection of experimental conditions and samples by researchers • Samples lineage • Compliant with repositories’ checklists and customisable • Controlled vocabularies • Ontologies from Ontology Lookup Service (OLS) • Samples metadata in tabular format • Import and export • Creation and editing in batch via Excel spreadsheet Dynamic table Future developments Samples query "List all the sequencing files originating from an Illumina MiSeq instrument and derived from the material named 'Yeast culture 1'." DataHub user interface and features • Research laboratories or units: enhance data management by integrating DataHub with ELNs and other existing systems. • Technical core facilities: utilize and share metadata standards with users. • Research institutes and consortia: • keep track of and discover datasets generated by various laboratories • support the implementation of FAIR and Open Science principles. Who can benefit from using DataHub Method: FAIRDOM-SEEK and ISA-JSON We develop features in FAIRDOM-SEEK1 that support structuring of the experimental metadata according to the established ISA metadata framework, in JSON format2. 1 DOI 10.5281/zenodo.5653415 2 https://doi.org/10.1093/gigascience/giab060 FAIR metadata by-design as a service for life s


Graph de-duplication: challenges & requirements De-duplicating the OpenAIRE Scholarly Communication Big Graph Claudio Atzori, Paolo Manghi, Alessia Bardi Institute of Information Science and Technologies, Italian National Research Council (ISTI-CNR), Pisa {name.surname}@isti.cnr.it Results ➢GDup Open Source Software: https: //doi.org/10.5281/zenodo.292980 ➢GDup is today a production service (TRL9) of the OpenAIRE infrastructure ➢GDup is used to de-duplicate literature, datasets, software and organisation entities to ensure sensible statistics are delivered by the OpenAIRE infrastructure. Ongoing & Future work ➢Make it a fully user-friendly product, i.e. completion of data curators GUI ➢Address further functional scenarios, e.g. crowd-sourcing deduplication by delegating to a set of experts the addition of assertions to clean deduplication results and build ground truth ➢Apache Spark to implement candidate identification and matching phases ➢Apache GraphX to implement the graph disambiguation phase Acknowledgments This work is partially supported by the European Commission as part of the projects ➢OpenAIRE2020 (H2020-EINFRA-2014-1, Grant Agreement 643410) ➢OpenAIRE-Advance (H2020-EINFRA-2017-1, Grant Agreement 777541) Solution proposed: GDup GDup is an integrated, scalable, general-purpose system for entity de-duplication over big graphs. GDup supports data curators with out of the box functionalities they require to support an end-to-end entity deduplication workflow over a generic input graph. GDup is not about better recall/precision for given deduplication problems, but rather about provision of tools enabling data curators to concentrate on modeling and customizing their deduplication solutions without bothering about the extra conceptual and technical challenges that such task implies. End-to-end workflow enabling data curators at: 1. Importing their graph in the system 2. Configuring for each entity type the relative duplicate identification “configurations” 3. Managing Ground Truth generation and injection 4. Configuring graph disambiguation strategies 5. Supporting data curators at manually fixing the results of deduplication 6. Exporting a disambiguated graph An academic graph aggregating all information required to deliver monitoring tools The scholarly graph is obtained as continuous aggregation of bibliographic metadata records originating from a variable set of information systems (repositories, publishers, funder databases) with heterogeneous and duplicated content. Main entities of the graph are organizations, results (literature, datasets, software, other products), funders, projects, and data sources. The graph counts ∼26Mi result entities, 2,5Mi projects, with∼40Mi links between them. Title Authors Date OpenAIREplus - OpenAIRE APIs for third party services. D8.6 Manghi et all 2012-06-12 OpenAIREplus - OpenAIRE APIs for third party services. D8.4 Manghi, P.; 2012-12-06 OpenAIREplus - OpenAIRE APIs for third party services. D8.6 Manghi Paolo NA 1 2 3 4 5 6


© 2020 Novartis Cheat sheet for model uncertainty assessment Version 1.2 Novartis Contributors: Andrew M Stein, Jeffrey D Kearns, Jaeyeon Kim, Alison Margolskee Purpose of this document The Pedigree Table on the back of this document helps a modeler or reviewer assess the uncertainty of a model’s predictions in a structured way [1, 2]. This tool should be applied during scoping, to ensure effort is placed on the most critical aspects of the model, and then applied again at the end of the activity, to ensure the model is fit for the purpose of informing the decision. In practice, the act of thinking carefully about model uncertainty and its consequences is more important than the exact choice of scores. Because model uncertainty is difficult to rigorously quantify, this assessment is qualitative, and reviewers may differ in their assessment. This difference in opinion can be useful information and it is recommended that the results from different reviewers be shown simultaneously to highlight areas of disagreement [2]. Figure 1 shows one way to visualize the results of the uncertainty assessment. This figure is illustrative and does not refer to specific models in the literature. Important Considerations Fit for Purpose: What is the purpose of this model? What are the key behaviors that it must capture? While complex models may be initially employed for hypothesis exploration, use the simplest model that addresses the specific question; reevaluate the model if the question changes. Consequences of incorrect prediction: If the model prediction is wrong, what are the consequences? What level of uncertainty can be tolerated? The pedigree table scores should reflect this. Range of predictions: How does the model uncertainty affect the decision or recommendation? Have you clearly defined a range of model predictions (i.e. ‘best’, ‘median’, ‘worst’ cases)? This representation is often more accessible to non-modelers than formal uncertainty metrics. References 1. Saltelli, A. "A short comment on statistical versus mathematical modelling." Nature communications 10.1 (2019), 1 2. Van Der Sluijs, JP., et al. "Combining quantitative and qualitative measures of uncertainty in model-based environmental assessment: the NUSAP system." Risk Analysis: An International Journal 25.2 (2005): 481. 2 3 1 1 2 1 0 2 2 3 2 1 2 2 2 2 3 4 4 4 2 3 4 3 3 4 4 4 4 4 4 4 3 3 4 4 M1 M2 M3 M4 Technical Implementation Parameter Sensitivity Variability Ability to Extrapolate Ability to Interpolate Assumptions Structural Model Biological Understanding Experimental Data Uncertainty Criteria Figure 1 Example pedigree table for four hypothetical models that were used to: explore hypotheses about a particular disease pathway (M1), predict the first in human dose (M2), select a phase 3 dose (M3), and support a change in label (M4).


Which Semantic Web? Marshall & Shipman* Problems with formality Conclusion: Semantic web design and adoption questions Three semantic web perspectives Pragmatic issues: The world-wide web does NOT have a consistent structure; it is not ordered or classified. Cognitive overhead: learning the representation (syntax and semantics) and making decisions on how to represent knowledge. Tacit and evolving knowledge Premature structure: - impedes & impairs classification - incremental structure development req'd. Situated nature of knowledge Sub-divide ideas & entities Find appropriate concepts Create concepts (when needed): - name it - connect to other concepts by attaching attributes and relations Knowing what to express (a learn by doing, trial and error, process) What is tacit knowledge? (Unspoken knowledge that may not be expressible in explicit language.) Formal representations are rigid (poor match for natural communications) Understanding of what is knowledge changes over time Natural categorizations (people give different names and attributes to the same objects in different contexts) Knowledge representation is problem dependent (attributes for objects and contexts are not enumerable (Kent, 2003 ?)) Knowledge stability (How well are the domain and its practices understood? How much formalization and restructuring is expected, or can be tolerated?) Competing conceptual approaches (Is the knowledge intrinsic or extrinsic? Can intrinsic structure be recognized with heuristic approaches; can declared representations be avoided or minimized?) Negotiation among information resource stakeholders (What roles do negotiation, facilitation, or intervention play in representing knowledge in a socio- technical framework? Are there identified and accepted approaches that work in the domain?) Universal Library: Existing tools (e.g., search) are sufficient; extend the web by defining and linking web information; enable more effective discovery, automation, integration, and reuse. Computer agent environment: Software agents can use defined and linked information to find, filter, and prepare information for people and procedures. Implementation is too hard in theory and in practice: (i) context-free knowledge representation relies on domain orientation; (ii) there is always a situation where more contextual information is needed. Federation of knowledge/data bases: most promising, can leverage information in existing relational databases, but requires - knowledge engineering (including social processes) - cataloging - librarianship Unruly properties of the (semantic) web: (i) AAA slogan (anyone can say anything about any topic; (ii) open world/ closed world (anyone can say something new about anything, hence there could always be more information); (iii) non- unique naming (many names for the same thing); (iv) it is an information wilderness (no guarantees that information is orderly or understandable) (Allemang & Hendler, 2011). Semantic Web as a metadata system Semantic Web as markup: HTML example; how complex and complicated will semweb markup get? (See W3C work on RDFa and Schema.org for current approaches. (LiDRC, 2010), (W3C, 2012).) Semantic Web as killer app: primary challenge is that it is difficult to keep detailed preferences in line with moment-to-moment needs Community centered: every aspect of metadata (collecting, validating, using) is a local practice; no set of cataloging rules ever fully prescriptive (cf. W. Kent, 2003). Cost: every metadata standard has an associated cost; each implementation must decide how much and who bears it? Authority and trust: knowing that the metadata is a good representation of content for its intended use is a challenge; needed early, but not later? * Marshall, C. & Shipman, F., Which semantic web?, Hypertext'03 (2003). Retrieved 2013-02-17 from: http://dx.doi.org/10.1145/900051.900063. W.L. Anderson, 2012, 2013, CC-BY References. Allemang, D. & Hendler J. (2011) Semantic Web for the Working Ontol


A trio of transiting Neptunian planets around HD 28109 (aka TOI-282) Florian Rodler (ESO Chile, frodler@eso.org) on behalf of Georgina Dransfield, Amaury H.M.J. Triaud, Davide Gandolfi, Juan Cabrera, Tristan Guillot, Djamel Mekarnia, David Nesvorny, Nicolas Crouzet, Lyu Abe, Karim Agabi, Marco Buttu, Maximilian N. Günther, François-Xavier Schmider, Philippe Stee, Olga Suarez, Karen A. Collins, Martín Dévora-Pajares, Steve B. Howell, Elisabeth C. Matthews, Matthew R. Standing, Keivan G. Stassun, Chris Stockdale, Samuel N. Quinn, Carl Ziegler, Ian J. M. Crossfield, Jack J. Lissauer, Andrew W. Mann, Rachel Matson, Joshua Schlieder and George Zhou Introduction. HD 28109 (TOI-282, where TOI stands for TESS Object of Interest) is a bright (V=9.4) main-sequence star, of spectral type F8/G0V, located in the southern continuous viewing zone of the Transiting Exoplanet Survey Satellite (TESS). TESS observations taken with 2 min cadence initially led to three transiting planet candidate signals: TOI-282.01 with an orbital period of about 56 days, .02 with a period of 31 days, and finally .03 with a period of 84 days. A search for additional candidates in the TESS data as well as in radial velocity data revealed that the candidate feature .02 with a period of 31 days was spurious; instead, a further candidate signal .04 with an orbital period close to 23 days was identified (Fig. 1). We furthermore excluded the presence of background stars of / stellar companions to HD 28109 by using high-resolution imaging data with NACO (VLT), Zorro (Gemini South) and with SOAR. We verified the three candidate signals with photometry and radial velocity (RV) follow-up. Transit-time variations (TTVs). Given the proximity of the orbital periods of the two outer planets to a first order 3:2 mean-motion resonance (84.3 vs 56 days), these planets experience some mutual gravitational influence leading to TTVs. Fig. 2 shows that these planets present very clear and significant anti-correlated TTVs with peak to peak amplitudes of ∼50 min and ∼100 min respectively. This allowed us to put constraints on their masses (see table below). Radial velocity (RV) measurements. We are currently conducting an RV survey with ESO's ultra- stable spectrographs HARPS and ESPRESSO to further characterize the planetary system (Fig. 3). Stellar activity in the star, which exhibits stellar jitter on the order of 2.5 - 3 m/s, plus the low masses of the planets and the resulting small RV semi-amplitudes ranging from only 0.8 to 2.4 m/s, make this RV follow-up a very challenging task. Results. The following table lists the fundamental parameters derived from our analysis, with their error values specified in parentheses. The mass estimates for the planets are derived by RV measurements as well as by TTVs (the latter for planets c and d; marked with asterisk*). Fig. 4 shows that the inner planet b is supposedly a rocky sub-Neptunian with a density of Earth, while the outer two planets are fluffy, gaseous Neptunians. The results are currently published in Dransfield++ (MNRAS, under review). The ongoing RV survey will be published in Rodler++. Figure 1: Global fit of the TESS photometry data for each planet (phase folded). The colored data points present the TESS data taken with 2 minutes cadence, while the white circles are binned data. Figure 2: Transit-time variations (in minutes) for the planets c and d spanning over three years of TESS data plus ground-based photometric monitoring. Candidate → Planet Orbital Period (days) Semi-major axis (AU) Radius (Earth) Mass (Earth) TOI-282.04 → HD 28109 b 22.891 (0.0004) 0.14 (0.003) 2.2 (0.1) 11.4 (2.6) TOI-282.01 → HD 28109 c 56.008 (0.002) 0.31 (0.011) 4.2 (0.11) 10.2 (3.6); 7.9* (3.8)* TOI-282.03 → HD 28109 d 84.26 (0.007) 0.41 (0.016) 3.3 (0.11) 8.1 (4.1); 5.7* (2.5)* Figure 3: Radial velocity fit based on 38 HARPS and 44 ESPRESSO measurements. Figure 4: Mass-radius diagram showing the positions of HD 28109 b, c and d. While the innermos


López-Hernández María A. 1 , Montilla Luís M. 1 , Verde Alejandra 1, Agudo- Adriani Esteban 1, Rivera Andreína 1, Miyazawa Emy 1 , Mariño Gloria 1 , Ascanio Alfredo 1 , Cróquer Aldo 1*. 1* Laboratorio de Ecología Experimental – Universidad Simón Bolívar. 1 panamalopezh@Gmail.com – Caracas, Venezuela *acroquer@ubs.ve – Caracas, Venezuela • Venezuelan coral reefs: A health assessment using the Reef Health Index with complementary variables THE PROBLEM REEF HEALTH INDEX The implantation and development of new methods aimed to assess the health status of coral reefs is a tenet core for the conservation science of these systems. For years, coral reefs communities have been described in Venezuela; however, no efforts to classify the health status of these systems have been accomplished. Part of the problem is that reefs have being always classified in terms of live coral cover, while other variables clearly linked with healthy reefs have been neglected. We used a modification of the Reef Health Index (RHI) proposed by The Nature Conservancy (TNC, 2016), with the addition of two variable: complexity index and algal turf height; because these two variables are currently seen as important proxies of reef health. HOW DID WE DO IT? The Reef Health “scores” are calculated by converting the average data value of each indicator into a condition ranking from ‘critical’ to ‘very good’ based on reference values (above). The seven scores are averaged to obtain the overall RHI score. In this work, we aimed to assess the health status of 36 reef sites encompassing seven different geographical locations in Venezuela using a multivariate approach. CRITICAL POOR FAIR GOOD VERY GOOD VARIABLES The Reef Health Index Turf Heigth (mm) Scleractinian Cover (%) Complexity Index Forager Fish Biomass (kg/100 m2) Fleshy Algae Cover (%) Commercial Fish Biomass (Kg/100 m2) < 0, 42 ≥ 0,42 - < 0,84 ≥ 0,84 - < 1,26 ≥1,26 - < 1,68 ≥ 1,68 OUR RESULTS 1 2 3 4 5 6 7 Our results indicated that health conditions in the reef sites of Venezuela are variable; we observed reefs that are in excellent condition, but also, we have degraded reefs. Additionally, this index offers a valuable tool for managers, educators and policy makers interested to implement future conservation actions in Venezuela. Only a few sites within Mochima National Park (Gabarra and San Agustín) and Cubagua (Punta Conejo) were rated as “Poor” and/or “Critical”. “Fair” sites were most likely located in Chichiriviche (La Pared, Punta Media Legua and Petaquire) and Los Frailes (La Pecha). IMPLICATIONS OF OUR FINDINGS Los Roques National Park (Boca de Cote, Rabusqui and Dos Mosquises), Morrocoy National Park (Cayo Norte and Sombrero) and Ocumare (Ciènaga Interno and Ciénada Oeste) the ones with the highest RHI values. 1 Morrocoy 2 Ocumare 3 Chichiriviche 4 Los Roques 5 Mochima 6 Cubagua 7 Los Frailes Boca Seca Bajo Caimán Cayo Medio Cayo Mero Cayo Norte Cayo Sombrero Cayo Sur Ciénaga Interno Ciénaga Este Ciénaga Oeste Guabinitas Tiburòn Media Legua La Pared Petaquire Punta Media Legua Punta Mono La Venada Cayo Agua Boca de Cote Dos Mosquises Madrisqui Rabusqui Salinas Garrapata Carabela Blanca Gabarra Punta Cruz San Agustín Charagato La Muerta Punta Conejo Cominoto La Pecha Puerto Real SITES VALUE Venezuela`s RHI VARIABLES: Forager Fish Biomass Scleractinian Cover Turf Heigth Complexity Index Fleshy Algae Cover Commercial Fish Biomass Overall RHI VALUE: Critical Very Good 1 - 1.8 1.9 - 2.6 2.7 - 3.4 3.5 - 4.2 4.3 - 5 ≥ 16 < 16 - ≥ 12 < 12 - ≥ 8 < 8 - ≥ 4 < 4 < 5 ≥ 5 - < 10 ≥ 10 - < 20 ≥ 20 - < 40 ≥ 40 < 1.5 ≥1.5 - < 2 ≥2 - < 2.5 ≥2.5 - < 3 ≥3 < 0,96 ≥3,48 > 25 ≤ 25 - > 12 ≤ 12 - > 5 ≤ 5 - ≥ 1 < 1 ≥ 2,88 - < 3,48 ≥ 1,98 - < 2,88 ≥ 0,96 - < 1,98


An Energy Data Service Platform for Whom? Understanding the Needs of the Energy Research Community Franziska M. Hoffart1,2; 1Sociological Research Institute Göttingen Nina Kerker1; 2Energy, Transportation, Environment Department, German Institute for Economic Research Oliver Werth3 3OFFIS e. V. – Institute for Information Technology, Oldenburg Poster designed by Hanna Pohlmann Task Area 1 of the nfdi4energy project 1. Introduction: Relevance and Objectives • To combat climate change, energy transition and energy system transformation are crucial significant role of energy-related research • For the required research, access to data is necessary to develop new theories and models • (Energy) research lags behind in promoting open data various projects and initiatives are building data platform solutions • New developments might be difficult to oversee • NDFI4Energy aims to develop and provide an open and FAIR research ecosystem addressing the whole research cycle • Includes successful elements of existing platforms and solutions and addresses unsolved and new challenges faced by researches • Key: identifying and understanding the needs of the energy research community • Who makes up the energy research community? What are the needs of its members in terms of platform development? 1 NFDI4Energy platform M1.1 Requirements of research community M1.2 Feedback mechanisms for platform M1.3 Development of platform M1.4 Development of content for best practices TA6 (Use Cases for Community Services) Content Services Requirements TA2 (Integrating Society and Policy in Energy Research) + TA3 (Transparency and Involvement of the Energy-Related Industry) TA4 (FAIR Data for Energy System Research) + TA5 (Simulation in Interdisciplinary Energy Research) + Techno-Economic Investigation Socio-Technical Perspective • Platform requirements cannot be identified without acknowledging the increasing diversity and interdisciplinarity of the energy research community • In the beginning, energy research had a techno-economic focus, today it is seen as a socio-technical transition embedded within society and current socio-ecological challenges • Inclusion of non-technical aspects e. g. political feasibility, social acceptance and just energy transition • Evolution calls for the strengthening of non-technical research, e. g. from the social sciences to introduce new perspectives, approaches and tools 2. Who is the Energy Research Community? Evolution of the Energy Research Community 3. Platform Requirement Analysis Expert interviews with scientists from different disciplines of the energy research community Questions include, among others: • What do you understand by the term energy research? • How do you rate access to these resources in the energy research community? (Where do you see room for improvement in procurement?) • In principle, would you be prepared to store your research outputs in a public data archive and make them accessible? • Which specific functions or services would you consider particularly valuable on a platform for networking the interdisciplinary energy research community? Preliminary results regarding challenges, needs and potential services for platform development: 1. Challenge: Overinvestigation in certain areas, where multiple researchers are active in the same regions, leading to duplicated efforts and frustration among respondents. 2. Need: Easily accessible information on other research projects, including geographical area, time frame, research interests, and contact details. 3. Potential Service: Visual map illustrating the "activity regions" of research project 4. Conclusions • The researchers proposed an approach that combines research community analysis with platform requirement analysis which can be worthwhile for other research domains • Acknowledging the development of the energy research community over the last decades towards more social science integration and interdisciplinary research, the community could b


Simulations for Planning Next-Generation Exoplanet Radial Velocity Surveys Patrick D Newman1, Peter Plavchan1, Jennifer A. Burt2, Johanna Teske3, Eric E. Mamaje2, Stephanie Leifer4, B. Scott Gaudi5, Garry Blackwood2, Rhonda Morgan2 1George Mason University, 2Jet Propulsion Laboratory, 3Carnegie Institution for Science, 4The Aerospace Corporation, 5The Ohio State University Abstract Future direct imaging missions such as HabEx and LUVOIR aim to catalog and characterize Earth-mass analogs around nearby stars. The exoplanet yield of these missions will be dependent on the frequency of Earth-like planets, and potentially the a priori knowledge of which stars speciﬁcally host suitable planetary systems. Ground or space based radial velocity surveys can potentially perform the pre-selection of targets and assist in the optimization of observation times, as opposed to an uninformed direct imaging survey. In this paper, we present our framework for simulating future radial velocity surveys of nearby stars in support of direct imaging missions. We generate lists of exposure times, observation time-series, and radial velocity time-series given a direct imaging target list. We generate simulated surveys for a proposed set of telescopes and precise radial velocity spectrographs spanning a set of plausible global-network architectures that may be considered for next generation extremely precise radial velocity surveys. We also develop ﬁgures of merit for observation frequency and planet detection sensitivity, and compare these across architectures. From these, we draw conclusions, given our stated assumptions and caveats, to optimize the yield of future radial velocity surveys in support of direct imaging missions. We ﬁnd that all of our considered surveys obtain suﬃcient numbers of precise observations to meet the minimum theoretical white noise detection sensitivity for Earth-mass habitable zone planets, with margin to explore systematic eﬀects due to stellar activity and correlated noise. Survey Targets, Goals, and Architectures 50 100 150 200 250 300 350 Day of Year 0.0 0.2 0.4 0.6 0.8 1.0 Fraction of Clear Nights Site Weather Mauna Kea Kitt Peak Calar Alto Las Campanas Sutherland Siding Spring Figure: Left: General diagrams of diﬀerent architecture(telescope/spectrograph combinations). Right: Nightly weather (as fraction of useable nights) at the sites considered for these surveys. We took a list of 101 nearby (≤15 pc) FGK stars that are considered both good direct imaging and RV targets, and split them into two mostly non-overlaping groups (51 north and 58 south). We performed simulated 10 year surveys on them across seven diﬀerent architectures (telescope/instrument combinations) on six diﬀerent sites (3 north, 3 south). Architecture I IIa IIb V Telescopes 6x2.4 m 2x6 m and 4x4 m 6x4 m 6x3 m Collecting area by aperture 2.4 m = 4.2 m2 4 m = 9.5 m2; 6 m = 27 m2 4 m = 9.5 m2 3 m = 6.3 m2 Time allocation 100% 100% 100% 100% Wavelength coverage 380-930 nm 380 - 930 nm 380 - 930 nm 500-1700 nm Spectral resolution 180 000 180 000 180 000 180 000 Total system eﬃciency 6% 6% 6% 7% instrument noise ﬂoor 10 cm/s 5 cm/s 5 cm/s 10 cm/s Required (peak) SNR/pix 300 300 300 300 Required RV precision 10 cm/s 10 cm/s 10 cm/s 10 cm/s Observation cadence per star 1 / night 3 / night 3 / night 2 / telescope / night Architecture VI VIIIa VIIIb Telescopes 6x arrays of 1 m 2x10 m and 4x 3.5 m 2x10 m and 6x2.4 m Collecting area by aperture 0.61m2 each; array is 9.5 m2 10 m = 75 m2; 3.5 m = 9.5 m2 10 m = 75 m2; 2.4 m = 4.2 m2 Time allocation 100% 25% of 10 m; 100% of 3.5m 25% of 10 m; 100% of 2.4 m Wavelength coverage 500-800 nm 380-930 nm 380-930 nm Spectral resolution 150 000 180 000 180 000 Total system eﬃciency 6% 6% 6% instrument noise ﬂoor 10 cm/s 5 cm/s 5cm/s Required (peak) SNR/pix 300 1000 for the 10 m; 300 for 3.5 m 1000 for the 10 m; 300 for 2.4 m Required RV precision 10 cm/s 15 cm/s on 3.5 m; 5 cm/s on 10 m 15 cm/s on 2.4 m; 5 cm/s on 10 m Obser


Poster: Expectations, Perceptions, and Misconceptions of Personal Firewalls Fahimeh Raja, Kirstie Hawkey, Pooya Jaferian, Konstantin Beznosov, Kellogg S. Booth University of British Columbia Vancouver, Canada {fahimehr,hawkey,pooya,beznosov}@ece.ubc.ca, ksbooth@cs.ubc.ca 1. INTRODUCTION Personal ﬁrewalls are recognized as the ﬁrst line of de- fense for personal computers. However, the protection they aﬀord depends strongly on their correct conﬁguration [4]. Therefore, their usability is key to their eﬀectiveness. In particular, as users become increasingly mobile, it is impor- tant for them to be able to judge whether their computer is secure enough for the usage context at hand [2]. Our prior research [5] revealed that the lack of an ac- curate mental model about the ﬁrewall’s system model is one of the root causes of users’ errors when conﬁguring the ﬁrewall. The results of a laboratory study showed that an improved user interface design that incorporated feedback about the state of the ﬁrewall in diﬀerent network contexts could help users develop more eﬀective mental models of the ﬁrewall and improve their understanding of ﬁrewall’s conﬁg- uration, resulting in fewer dangerous errors. However, we also learned that a large proportion of users did not see the need for multiple proﬁles based on context. In this research, our goal is to better understand users’ knowledge, expectations, perceptions, and misconceptions of personal ﬁrewalls. We conducted interviews with 30 par- ticipants and analyzed the data using qualitative descrip- tion [7]. The results from 10 interviews are presented in [6]. In this paper we present our aggregated results and examine their implications for the design of personal ﬁrewalls. 2. METHODOLOGY We conducted semi-structured interviews to answer the following research questions: 1) What do users know and what misconceptions do they have about personal ﬁrewalls and the protection provided by them? 2) What expectations do users have of an application such as a personal ﬁrewall? 3) How do users prefer to interact with an application such as a personal ﬁrewall (i.e., the level of automation, feedback)? 4) Do the users need to have diﬀerent levels of protection for an application such as a personal ﬁrewall? Why? and 5) What factors, do the users think, aﬀect their required level of protection from an application such as a personal ﬁrewall? We recruited 30 participants from both the university and general community. They had a wide range of edu- cational levels, backgrounds, and occupations. Almost all (28) used a laptop in a variety of network contexts. We classiﬁed their security knowledge and experience into three categories: high (H), medium (M), and low (L) in order to examine their expectations, perceptions, and misconcep- tions of a personal ﬁrewall in relation to their level of security knowledge and expertise. Table 1 shows their demographics. Group L M H Total Security Level Low Medium High N/A Group Size (N) 13 11 6 30 Age Mean 28.4 26.5 26.2 27.3 Range 20-51 22-32 26-27 20-51 Gender Female 9 3 1 13 Male 4 8 5 17 Student Yes 5 6 4 15 No 8 5 2 15 Table 1: Participants’ demographics. 3. RESULTS None in group L knew about the functionality of a ﬁrewall. Their comments show their misconceptions about the pro- tection provided by diﬀerent security software. Most of them did not know whether or not they had a ﬁrewall on their computer. All in group H and 6 in group M had previous experience conﬁguring a ﬁrewall. Others in group M were not sure about the functionality of a ﬁrewall. Some com- ments from these participants show that they faced problems in conﬁguration of their ﬁrewall (e.g., in allowing a printer connection), which resulted in them turning the ﬁrewall oﬀ. We examined if participants’ required level of protection from their personal ﬁrewall varies depending on the context. All in group H and 7 in group M wanted varying levels of protection based on their activity (e.g., online banking vs.


Anja Gerber Klassik Stiftung Weimar Prof. Dr. Günther Görz, Dr. Sarah Wagner FAU Competence Center for Research Data & Information Die Objektbiograﬁe als Ansatz für Datenintegration Was ist eine Objektbiograﬁe? • Sie überträgt das Konzept der Biograﬁe auf materielle Kulturgüter und bildet eine wichtige Grundlage für archäologische und objektbasierte Forschung, • kompiliert jegliche Information (Kontexte, Wege, Bedeutungen, Deutungen) zu einem Objekt, • ist chronologisch, aber nicht linear und durchzogen von Lücken, • Kontexte umfassen u. a. Herstellung oder ideelle Konzeption eines Gegenstandes, Nutzungsphasen bei Artiﬁcialia; Geburt, Lebensraum, erdzeitliche Entstehung, Präparation bei Naturalia; Phase(n) des Vergessens, Fund, Ausgrabung, Eingang in einen Sammlungskontext, Ausstellung, Erforschung, Modiﬁkation, Restaurierung, Rezeption, Zerstörung, Restitution oder Repatriierung, • Es können mehrere Sichtweisen und verschiedene Kontexte gleichzeitig existieren, • Akteur*innen stellen Objekte her, nutzen sie, entnehmen sie aus der Natur, graben sie aus, erwerben oder rauben sie, präparieren und restaurieren sie, stellen sie aus, setzen sie in Beziehung, erforschen sie und rekonstruieren letztlich ihre Biograﬁe, • Quellen (Bild- und Schriftgut, Datenbanken) bilden die Grundlage der Informationsrekonstruktion und -provenienz. Chancen der Objektbiograﬁe • Ermöglicht eine detaillierte Aufarbeitung von Fund- oder Erwerbsumständen, • betrachtet alle Phasen und damit die dabei zugewiesenen Informationen gleichwertig, • schafft eine Metaperspektive auf Wissensobjekte, da der gegenwärtige Sammlungskontext, aus dem heraus vorwiegend dokumentiert wird, nur einen von vielen bildet, • Bedeutungszuschreibungen von Akteur*innen und Gruppen auch außerhalb des Sammlungs- /Museums- oder des wissenschaftlichen Kontextes werden egalitär einbezogen (Herkunftsgesellschaften, Populärkultur usw.). Digitale Objektbiograﬁen • Vernetzung heterogener und verteilter Informationen, • Objektbiograﬁe als „Maximaldatensatz“, • multiperspektivischer Zugriff, disziplinübergreifende Recherche, • Abbildung von Informationsprovenienz, Mehrdeutigkeit und Widersprüchlichkeit, • Kontextualisierung der zugewiesenen Objektinfor- mationen, Zeit, Ort, Akteur*innen, Quellen über Ereignisse, • Anwendung des CIDOC CRM als ISO-zertiﬁzierter Beschreibungsstandard für das Kulturerbe. Abstract Die Entwicklung von Konzepten zur semantischen Harmonisierung von Objektinformationen bildet einen zentralen Arbeitsbereich in Task Area 6, bei dem die Klassik Stiftung Weimar und das FAU Competence Center for Research Data and Information eng zusammenarbeiten. Dabei wird das Konzept der Objektbiograﬁe mit Semantic-Web-Technologien ins Digitale übertragen, um heterogene, multidisziplinäre Daten der NFDI4Objects-Community zu integrieren und so zu vernetzen, damit institutions- und bestandsübergreifende Fragestellungen beantwortet werden können. Abbildungen: Anja Gerber, Sarah Wagner, CC-BY 4.0 Zitation: Gerber, A., Goerz, G., Wagner, S. (2024, September 15-17). Die Objektbiograﬁe als Ansatz für Datenintegration. NFDI4Objects Community Meeting, Mainz. Zenodo. https://doi.org/10.5281/zenodo.13757398. Schematische Darstellung einer Objektbiograﬁe: Im Zentrum steht das Objekt (Artiﬁcialie oder Naturalie), das je nach Objektart und Herkunft in verschiedene Kontexte eingebettet ist/war. Diese werden jeweils durch Angaben zu Zeit und Ort genauer beschrieben, mit Akteuren verbunden und schließlich mit Quellen belegt. Talk to us! Literatur (Auswahl, vollständige Liste ﬁndet sich bei Zenodo): Kopytoff, I. (1986) The Cultural Biography of Things. In: The Social Life of Things. Hg. v. Arjun Appadurai, Cambridge, S. 64-91. Braun, P. (2015). Objektbiographie. Ein Arbeitsbuch. Thiery, Florian u. a. (2023). ‘Object-Related Research Data Workﬂows Within NFDI4Objects and Beyond’. In 1st Conference on Research Data Infrastructure (CoRDI) - Connecting Communities, edited by York Sure-Vetter and Carole Goble,


Examination of reliability of nuclear matrix elements of neutrinoless double-β decay by QRPA J. Terasaki, Institute of Experimental and Applied Physics, Czech Technical Univ. in Prague Y. Iwata, Faculty of Chemistry, Materials and Bioengineering, Kansai University The goal is to determine the effective mass of the neutrino. The double-β decay of nucleus is used for this purpose. We aim at the theoretical contribution. Possible change of two neutrons to two protons in a nucleus emitting two electrons with neutrino exchange (neutrinoless double-β decay). This decay occurs, if the neutrino（ν） is a Majorana particle (𝜈= 𝜈̅ ), and the effective neutrino mass can be determined; see the equations below. Determination of the effective neutrino mass is one of the most important subjects in modern physics. 𝜈𝑒 𝑛 𝑛 𝑝 𝑝 𝑒− 𝑒− 𝜈̅𝑒 Nucleus of (neutron number, proton number) = (𝑁, 𝑍) Nucleus (𝑁−2, 𝑍+ 2) Why nuclei? Because 𝐸(final state) < 𝐸(initial state) is necessary. Other conditions for the nuclei used in the experiments: Single beta decay is suppressed. The energy spectrum of two electrons in 2𝜈𝜈𝜈 decay can be distinguished well from that of 0𝜈𝜈𝜈. Large Q value [ ≈𝐸(initial state) −𝐸(final state)]. The parent nuclei can be produced massively with high purity. 76Ge→76Se 130Te→130Xe 136Xe→136Ba 150Nd→150Sm 48Ca→48Ti 82Se→82Kr 96Zr→96Mo 100Mo→100Ru 110Pd→110Cd 116Cd→116Sn 124Sn→124Te and more List of decays searched in the experiments 1/𝑇0𝜈(g. s. →g. s. ) = 𝑀0𝜈 2𝐺0ν𝑔𝐴 4 𝑚𝜈 𝑚𝑒 2 Half-life Nuclear matrix element Phase -space factor Effective 𝜈 mass Principle to determine effective neutrino mass 𝑚𝜈= ෍𝑈𝑒𝑒 2 𝑚𝑖 𝑖=1,2,3 Theoretical calculation Experimental measurement U : Pontecorvo–Maki– Nakagawa–Sakata matrix 𝑚𝑖: eigen mass (i =1,2,3) Axial-vector current coupling 𝑚𝑒: electron mass Phase-space factor ← Wave functions of emitted electrons Nuclear matrix element ← Nuclear wave functions Approximation is indispensable. Accurate calculation more difficult than the phase-space factor Nuclear matrix element 𝑉𝑟12, 𝐸𝑏≅ℎ+ 𝑟12, 𝐸𝑏 {linear combination of Double- Gamow- Teller and Double- Fermi operators} 𝑀(0𝜈) = ෍෍෍⟨𝑝𝑝′ 𝑉𝑟12, 𝐸𝑏𝑛𝑛′⟩⟨0f +|𝑐𝑝′ † 𝑐𝑛′|𝑏⟩ 𝑛𝑛′ 𝑝𝑝′ 𝑏 ⟨𝑏|𝑐𝑝 †𝑐𝑛|0i +⟩ The transition operator used in our calculation is Final state, ground state of nucleus(N-2,Z+2) intermediate state, nucleus (N-1,Z+1). Energy is Eb. Initial state, ground state of nucleus (N,Z) ℎ+ 𝑟12, 𝐸𝑏 : neutrino potential; energy denominator included Status and purpose of this study: The calculated nuclear matrix elements by various approximation methods and groups are distributed in a range of factor of 2‒3. The nuclear matrix element cannot be obtained by experiment. Thus, examination and improvement of the calculation are essential. Approximation to the method to obtain the nuclear wave functions in our study: Quasiparticle random-phase approximation (QRPA) How good? • Transition-strength function can be well reproduced. • Sum rule is satisfied. • Widely used in nuclear and condensed-matter physics. Nuclear excitation is described as the superposition of two-quasiparticle excitations. Under the approximation to the equation of the nuclear matrix element by 𝑉𝑟12, 𝐸𝑏≅𝑉𝑟12, 𝐸ത𝑏 𝐸ത𝑏: average energy of the intermediate states |𝑏⟩, a virtual decay path is possible to use for calculation as two-neutron removal followed by two-proton addition. The nuclear matrix element of the virtual path must be equal to that of the double-β path. This is a constraint to the effective interactions used for the approximation. The strength of the isoscalar proton-neutron pairing interaction is determined. J. Terasaki, Phys. Rev. C 91, 034318 (2015); ibid 93, 024317 (2016) Why important? This interaction is necessary for calculating the nuclear matrix element of two-neutrino double-β decay. There are exp. data of half-life to this decay for those nuclei used for the neutrinoless double-β decay exp. The two-neutrino decay operator 𝑉2ν 𝐸𝑏 cannot be replaced by 𝑉2ν 𝐸ത𝑏, thus, the double-β-path calcul


I SIMPOSIO DE OBSTETRICIA CON ÉNFASIS EN LA SALUD MATERNA Y NEONATAL SATISFACCIÓN DEL USO DE LOS MÉTODOS ANTICONCEPTIVOS EN UNIVERSITARIOS DE LA CARRERA DE OBSTETRICIA Y TEATRO DE LA UNIVERSIDAD CENTRAL DEL ECUADOR. Niurka Cuji Choto 1 y Carmen Durán 2 1 estudiante de la Carrera de Obstetricia, Facultad de Ciencia Médicas de la Universidad Central del Ecuador, Quito, Ecuador 2 Docente tutora de la Carrera de Obstetricia, Facultad de Ciencia Médicas de la Universidad Central del Ecuador, Quito, Ecuador INTRODUCCIÓN: La educación sexual y reproductiva promueve el acceso a métodos anticonceptivos seguros y efectivos, generando un alto nivel de satisfacción entre los estudiantes, lo que permite disfrutar de una vida sexual saludable y responsable. Es crucial para prevenir los embarazos no deseados y las infecciones de transmisión sexual (ITS) (1). Por ello es importante conocer la percepción que tiene los estudiantes de la Universidad Central con respecto al uso de métodos anticonceptivos. OBJETIVO: Analizar el grado de satisfacción en el uso de métodos anticonceptivos entre las estudiantes de las carreras de Obstetricia y Teatro de la Universidad Central del Ecuador periodo abril- agosto 2024 METODOLOGÍA: Estudio descriptivo de corte transversal con una muestra a conveniencia en estudiantes de las carreras de Teatro y Obstetricia. La herramienta utilizada fue una encuesta anónima a través de Google Forms se obtuvo frecuencias y porcentajes utilizando el estadístico Excel. Aprobación ética y o consentimiento informado: Se solicitó el consentimiento informado previo a la participación de los estudiantes. RESULTADOS: La muestra consistió en 23 participantes (18 estudiantes de teatro y 5 estudiantes de obstétrica). La mayoría conocían sobre los métodos anticonceptivas a través de los medios de comunicación, la radio, el internet y la televisión. Estos métodos lo adquirían en un alto porcentaje comparando y muy poco frecuente a través de los centros de salud públicos. Los estudiantes encuentran satisfacción en el uso de los métodos anticonceptivos sobre todo del preservativo masculino y lo recomendarían. DISCUSIÓN: Los resultados de nuestro estudio revelan que la mayor parte de estudiantes tienen alto conocimiento sobre el uso de preservativos, seguido de las píldoras anticonceptivas e implantes. En estudios similares como el de Ky, McGeechan y K, Watson CJ 2021 describen el uso de métodos anticonceptivos de larga duración por la continuidad y satisfacción con relación a otros métodos difieren de nuestro estudio. (2). También los resultados revelan los estudiantes adquieren mayor conocimiento sobre métodos anticonceptivos a través de medios de comunicación, como la televisión y el internet, coincidiendo con Purdy CH. 2011 en el que describe que la información lo obtienen con mayor frecuencia a través del uso del internet y las redes sociales, por lo que las organizaciones de planificación familiar deberían aprovechar esta coyuntura para incorporar programas educativos, de divulgación y de marketing (3) CONCLUSIONES: Los estudiantes universitarios tienen acceso a la información sobre métodos anticonceptivos y utilizan con frecuencia. Es importante continuar mejorando la educación sexual y reproductiva, asegurar el acceso gratuito a los métodos para garantizar que todos los jóvenes puedan tomar decisiones informadas sobre su salud reproductiva. Por otro lado, algunos estudiantes mencionan efectos secundarios como Acné y cambios en la masa corporal al utilizar métodos anticonceptivos. A pesar de estos efectos, la mayoría de los encuestados se muestran satisfechos con los métodos que utilizan, y los recomendarían, siempre que estén bien informados por parte del personal de salud. Referencias 1. Schivone GB, Glish LL. Asesoramiento anticonceptivo para continuidad y satisfacción. Current opinion in obstetrics & gynecology. 2017; 6: p. 443-448. 2. negra Ky, McGeechan K, Watson CJ, Lucke J, Taft Á, McNamee K, et al. Satisfacción de las mujere


Minor Intron Genes as Potential Targets for Affecting Survival of Triple Negative Breast Cancer Cells Zoya Farooqui, Dr Ihab Younis, Dr Mazen Sidani Department of Biological Sciences, Carnegie Mellon University Qatar • Triple Negative Breast cancer (TNBC) is an aggressive cancer associated with lower survival, prognosis, and less treatment options. • Minor Intron genes (MIGs) have information processing functions. • Every hallmark of cancer is associated with a MIG. • Previous work on this research explored splicing behaviour of MIGs in breast cancer cells by manipulating levels of U6atac snRNA. Spliced mRNA Unspliced mRNA retaining minor intron After U6atac inhibition Class I: Accumulation of Unspliced mRNA Class II: No Accumulation of Unspliced mRNA Overall Aim: Build on previous research to broaden understanding of MIGs, their behaviour in TNBC and manipulate their splicing for potential thereaptuic advantage. Specific Aim 1: Understand why unspliced mRNA only accumulates for Class I MIGs. -Hypothesis : Unspliced mRNA for Class I genes holds translational potential. Specific Aim 2: Find a lowU6atac AMO dose that is critical for TNBC cells. • El Marabti, E., Malek, J., & Younis, I. (2021). Minor Intron Splicing from Basic Science to Disease. International journal of molecular sciences, 22(11), 6062.https://doi.org/10.3390/ijms2211606 • Hall, S. L., & Padgett, R. A. (1996). Requirement of U12 snRNA for in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns. Science (New York, N.Y.), 271(5256),1716- 17181https://doi.org/10.1126/science.271.5256.171 • Younis, I., Dittmar, K., Wang, W., Foley, S. W., Berg, M. G., Hu, K. Y., ... & Dreyfuss, G. (2013). Minor introns are embedded molecular switches regulated by highly unstable U6atacsnRNA. Elife, 2, e00780. Previous Research Exon Intron Categorization of MIGs in two classes: Research Aims Background Methodology Aim 1 Aim 2 Conclusions Future Directions Figure 2: 0.5μM U6atac AMO is a critical dose for MDA-MB-231 cells. (A) RealTime Glo viability assay on transfected MDA-MB-231 cells using MT reagent over 5 day period. * indicates significance of p-value <0. 05. (B) Compilation of percentage decrease in expression of spliced mRNA following 0.5μM U6atac AMO treatment using RT-qPCR data of tested MIGs. MIGs with 50% or more percentage decrease were considered significant. (C) Most significant Gene ontology results on sensitive MIGS. Figure 1:Treatment with U6atac AMO prevents translation of both Class I and Class II MIGs. RT-qPCR (A, C) splicing analysis and Western Blot image (B, D) of Class I (EIF3I) and Class II (MAPK14) MIGs. MDA-MB-231 cells were transfected with Control and U6atac AMO. RNA was extracted, converted to cDNA and used for RT-qPCR using QuantStudio 6 Flex thermocycler.Similarly, protein lysate were extracted from transfected cells, separated by SDS-PAGE, stained with specific antibodies. Results B C References • Protein expression of MIGs directly correlates with the splicing of their minor intron. • Unspliced mRNA for both Class I and Class II genes is not translated. • 0.5μM U6atac AMO dose affects replication and growth of MDA-MB- 231 (TNBC) cells. • Splicing of multiple MIGs is significantly affected by 0.5μM U6atac AMO treatment. • These sensitive MIGs form potential targets whose expression can be prevented to affect survival of TNBC cells. • Exploration of miRNA binding sites within minor introns of Class I and Class II genes to explain splicing trends observed in MIGs. • Testing 0.5μM U6atac AMO in non- breast cancer and other cancer cell lines to observe if its effect is specific to TNBC cells. • Manipulating expression of sensitive MIGs within TNBC cells. Transfection of MDA- MB-231 cells (TNBC) with U6atac AMO Protein Extraction Plating for Viability Assay RNA Extraction and cDNA synthesis Western Blot RealTime Glo Viability Assay Quantitative PCR (qPCR)


ExploreSalon: Unveil Hidden Stories from the Past Concept and Outcome of a Digital Humanities and Cultural Heritage "Hackathon" Charvat, Vera Maria; Ďurčo, Matej; Königshofer, Elisabeth; Petrovic-Majer, Sylvia; Woldrich, Anna "When people interact, they leave traces: uncountable letters, diaries, chronicles, plaques, and other written records have preserved memories about people – long before the rise of smartphones and social media."1 For the duration of one week (22nd – 26th May 2023) the so-called ExploreSalon will offer a collaborative space to explore digitized memories, in the form of curated biographic, spatial and temporal datasets with focus on Vienna 1900. The event will be organized by the Austrian Centre for Digital Humanities and Cultural Heritage (ACDH-CH) and supported by the CLARIAH-AT2 national consortium as part of its knowledge sharing activities. The ExploreSalon has two goals: Bring people of diverse backgrounds together and provide them with the opportunity to discover innovative ways of data-based storytelling – exploring stories hidden in the data, presenting ideas and sharing findings. The concept of the ExploreSalon is based on cultural hackathons, such as "OpenGLAM.at"3, "Coding Da Vinci"4 and "Coding Duerer"5. It departs from the traditional "hacking marathon" that is aimed primarily at people with a technical background. Instead, a cultural hackathon seeks to bring together all kinds of creative minds with different skills and levels of expertise from the (Digital) Humanities and Cultural Heritage sectors as well as GLAM (Galleries, Libraries, Archives and Museums) institutions. Inviting creativity as a form of generative change and providing space for the emergence of new ideas, shared purposes and a vivid community, this new kind of event is focusing on establishing a community of practice and enables all stakeholders to communicate at eye level. Dialogue and values like transparency, open knowledge and participatory leadership are propagated rather than a set of specific methods. Following a purpose-driven approach, ExploreSalon aims to empower the community of practitioners to govern their own work process by stepping away from rigid frames and time 5 https://codingdurer.de/ (last accessed: 2023-02-08) 4 https://codingdavinci.de/ (last accessed: 2023-02-08) 3 https://www.openglam.at/ (last accessed: 2023-02-08) 2 https://clariah.at/ (last accessed: 2023-02-08) 1 https://clariah.at/exploresalon2023 (last accessed: 2023-02-08)


Ryan Coulson1, 2, Max Kirkpatrick1, 3, Megan Robinson1, 4, Meghan Donahue5, Devin R. Berg1 1Engineering & Technology Department, University of Wisconsin-Stout; 2Department of Mechanical Engineering, Lafayette College; 3Department of Mechanical Engineering, University of South Carolina; 4Department of Electrical Engineering and Computer Science, Case Western Reserve University; 5Stout Vocational Rehabilitation Institute, University of Wisconsin-Stout User Testing of a Continuum Manipulator for Assistive Technology User No. Average Completion Time (s) – Session One Average Completion Time (s) – Session Two Average Completion Time (s) – Session Three Percent Improvement 1 115.18 121.79 58.84 48.91 2 121.79 112.57 66.02 42.96 3 170.65 149.66 120.40 29.45 User No. Average Completion Time (s) – Session One Average Completion Time (s) – Session Two Percent Improvement 1 235.14 168.18 28.47 2 234.57 214.89 8.39 3 435.57 288.30 33.81 Control Scheme Avg Completion Time (s) Standard Deviation (s) Average Intuition Ranking Single-Joystick Compensative 63.00 54.61 1.86 Dual-Joystick 72.76 42.60 1.93 Single-Joystick Segmented 96.20 55.58 2.21 The use of robots in assistive technology is well-studied, with numerous robotic arms for rehabilitative applications that have been designed and tested to-date, and several that are commercially available [1, 2, 3]. These robots are intended to improve independence and quality of life for people who are unable to perform activities of daily living (ADLs) without additional aid. Unfortunately, they are often prohibitively expensive, costing tens of thousands of dollars [4]. Additionally, they pose a risk of harmful collision to their users and must incorporate sophisticated sensors and control methods to ensure the users’ safety. This work evaluates an alternative platform for assistive robotics which alleviates these issues: continuum manipulators. Continuum manipulators are robots that lack rigid segments and discrete joints [5]. Instead, they function by bending continuously along their length, like the trunk of an elephant or the tentacle of an octopus. The use of continuum manipulators in assistive technology has been proposed with respect to the ADL of bathing by Ansari et al., 2017 [6], although no user testing of this proposal has been completed. This work is supported by the National Science Foundation under Grant No. CNS-1560219. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. Table 1. Results from Round One of user testing for n = 14 users. References [1] Chung, C. S., Wang, H., & Cooper, R. A. (2013). DOI: 10.1179/2045772313Y.0000000132 [2] Driessen, B. J. F., Evers, H. G., & v Woerden, J. A. (2001). DOI: 10.1243/0954411011535876 [3] Maheu, V., Archambault, P. S., Frappier, J., & Routhier, F. (2011). DOI: 10.1109/ICORR.2011.5975397 [4] Allin, S., Eckel, E., Markham, H., & Brewer, B. R. (2010). DOI: 10.1016/j.pmr.2009.09.001 [5] Walker, I. D. (2013). DOI: 10.5402/2013/726506 [6] Ansari, Y., Manti, M., Falotico, E., Mollard, Y., Cianchetti, M., & Laschi, C. (2017). DOI: 10.1177/1729881416687132 Table 2. Results from Round Two of user testing: Peg-in-hole task. Table 3. Results from Round Two of user testing: Drawer task. Table 1 shows the results from Round One of user testing. On average, users were able to complete the given task most quickly using Compensative control, followed by Dual control and then Segmented control. The standard deviations for these data are relatively large, as users demonstrated a wide range of skill levels when using the robot. Examining the average intuition rankings, it can be seen that users rated Compensative control as most intuitive, followed by Dual control and then Segmented control. This result further supports Compensative control as the superior of the three control schemes. Tables 2 and 3 show results from Round Two


Design and Development of Cooling Solutions for Rotating Detonation Engines Ramanagar S Shreyas, Sandri Umberto, Mazzei Lorenzo, Picchi Alessio and Andreini Antonio DIEF DEPARTMENT OF INDUSTRIAL ENGINEERING Quantification of Heat Flux Introduction One of the main challenges associated with the development of Rotating Detonation Combustion Engines (RDE) is dissipating the tremendous amount of heat generated by the high-frequency rotating detonation waves. The Current research aims to develop cooling designs for RDE. Wall heat flux contour of TU Berlin RDC operating in laboratory conditions obtained from LES simulation [3]. Bulk average heat flux of TU Berlin RDC obtained from LES simulation along with validation of the ROM. Heat Flux Modelling The wall heat flux is calculated with the following equation [1]. Making an assumption of single rotating detonation wave at all operating pressure. A simple scaling model is built which uses Shock and Detonation tool box [2] to obtain the detonation temperature. Scaled Heat Flux for different operating pressure. For an operating pressure of 5 bar the peak average heat flux is 6 MW/m2. Very high when compared to GT Engines. References: [1]Braun et al., Numerical assessment of the convective heat transfer in rotating detonation combustors using a reduced-order model. Applied Sciences, 2018, 8(6). [2]Browne, S et al., Numerical Solution Methods for Shock and Detonation Jump Conditions; GALCIT Report FM2006.006; GALCIT: San Diego, CA, USA, 2004. [3]Nassini Pier Carlo, High-fidelity Numerical Investigations of a Hydrogen Rotating Detonation Combustor, PhD Thesis, UniFI, 2022. [4] Tian et al., Numerical investigation on flow and film cooling characteristics of coolant injection in rotating detonation combustor. Aerospace science and technology, 2022, 122, 107379. “This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956803” Preliminary assessment of cooling solutions For aeronautical applications, forced air cooling is the best feasible option. Feasibility study of available cooling methods is performed. The cooling effectiveness (φ) required to maintain the liner temperature below the limit of 1200K is determined. Bulk averaged HTC and Gas Temperature calculated from data obtained from Braun et al. [1]. Effusion cooling assessment Due to detonation the use of TBC is not feasible. A protective layer which can rebuild itself quickly, even after disrupted by the detonation wave is the only possible solution. Researchers like Tian et al. [4] have already shown it is possible. As part of research activity, we are building a test rig to evaluate the experimental performance of effusion cooling in non reactive supersonic mainstream conditions. A reactive LES simulation of the RDE to assess the feasibility of Effusion cooling will be performed using AVBP solver. A Possible cooling system design of an RDE. Where the first part uses turbulators and effusion cooling for the rest. HTC augmentation of 15 with respect to a baseline smooth flat plate is not sufficient to obtain the required φ = 0.63. The current state-of-the-art forced convection cooling schemes are not sufficient, unless the walls are protected.


ICON-BASED COUPLED OCEAN-ATMOSPHERE DEMONSTRATOR Visualisation of cloud water and ocean currents in a 5km-5km ocean- atmosphere simulation. Left: Global view. Right: Zoom into Carribean sea. A throughput of ca. 20 simulated days/day was achieved on 500 Broadwell nodes (platform: Mistral, DKRZ). ATMOSPHERE-ONLY DEMONSTRATORS Global ICON-based weather forecast, run at a global resolution of 2.5km. Scalability of global high-resolution atmosphere-only simulations using the models IFS and ICON (no I/O). Despite significant achievements for extreme scale simulations, even more effort is required to push the models towards production readiness (target throughput: ca. 365 forecast days/day). References: T.C. Schulthess, P. Bauer et al. IEEE Comput. Sci. Eng. 21(1), 2019, https://doi.org/10.1109/MCSE.2018.2888788 P. Neumann, P. Düben et al. Philos. Trans. Royal Soc. A 377(2142), 20180148, 2019, https://royalsocietypublishing.org/doi/pdf/10.1098/rsta.2018.0148 THE CENTRAL DELIVERABLE: GLOBAL HIGH-RESOLUTION DEMONSTRATORS ESiWACE will deliver global high-resolution demonstrators of atmosphere- only, ocean-only and coupled ocean-atmosphere simulations; a key target is to reach spatial resolutions of ca. 1 km that allow simulating convective clouds and small-scale ocean eddies. This will provide much more fidelity in the representation of high-impact regional events. The demonstrators will allow for computability estimates for these configurations at exascale. They are based on widely used European models (IFS, ICON, NEMO, EC-EARTH). In this context, ESiWACE has been strongly supporting the intercomparison project DYAMOND, integrating both views on performance and science case. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 675191. The poster reflects only the authors’ view. The EC is not responsible for any use that may be made of the information it contains. Visualisations are courtesy by Niklas Röber, DKRZ. © Deutsches Klimarechenzentrum GmbH, Bundesstr. 45a, 20146 Hamburg, Germany OVERVIEW Funding period: 1 Sep 2015 – 31 Aug 2019 Coordination: DKRZ (Joachim Biercamp), ECMWF (Peter Bauer) Consortium: 16 partners from 7 countries Call reference: European research infrastructures, EINFRA-5-2015 The Centre of Excellence in Simulation of Weather and Climate in Europe (ESiWACE) forms a joint scientific community around Earth System Modelling (ESM) from the two communities of Weather and Climate research by leveraging two established European networks: • The European Network for Earth System Modelling • The European Centre for Medium-Range Weather Forecasts The main objectives of ESiWACE are to • Substantially improve efficiency and productivity of numerical Weather and Climate simulation on high-performance computing (HPC) platforms, strengthening the user-driven evolution of the community software • Build a critical mass and create expertise to increase the community impact on hardware development towards the extreme scale as well as future international exascale initiatives THE STORY CONTINUES: ESiWACE2 Funding period: 1 Jan 2019 – 31 Dec 2022 Coordination: DKRZ (Joachim Biercamp), ECMWF (Peter Bauer) Consortium: 20 partners from 9 countries Call reference: European research infrastructures, INFRAEDI-02-2018 The project will push the global high-resolution demonstrators towards production-ready simulations on European pre-exascale and future exascale systems. ESiWACE2 will further focus on exploring and exploiting suitable innovative technologies such as DSLs, on the development of processing tools for more efficient I/O and visualisation and on providing enhanced services, training and benchmarks for the community. ESiWACE Contacts Presenter: Philipp Neumann Web: www.esiwace.eu E-Mail: esiwace@dkrz.de PROJECT IMPACTS AND ACHIEVEMENTS ESiWACE addresses three core themes on the applications’ way towards exascale computing: • Scalability of models and tools


Thamil Arasu Saminathan , Muhammad Fadhli , Tania Gayle , Halizah Mat Riﬃn , Hasimah Ismail , Norazizah Ibrahim Wong , Wan Shakira , Hooi Lai Seong , Sunita Bavanandan , Ghazali Ahmad , Ong Loke Meng , Esther Tan , Irene Wong , Fatimah Othman , Hamizatul Akmal , Haji Tahir Aris 1 Institute for Public Health, National Institutes of Health Malaysia, Ministry of Health Malaysia 2 Sector for Biostatistics & Data Repository, National Institutes of Health Malaysia, Ministry of Health Malaysia 3 Sultanah Aminah Hospital, Johor, Ministry of Health Malaysia 4 Kuala Lumpur Hospital, Ministry of Health Malaysia 5 Pulau Pinang Hospital, Ministry of Health Malaysia 6 Clinical Research Centre, Penang, Ministry of Health Malaysia 7 Selayang Hospital, Ministry of Health Malaysia 8 Tengku Ampuan Rahimah Hospital, Klang, Ministry of Health Malaysia 9 Institute for Medical Research, Ministry of Health Malaysia 1. Institute for Health Metrics and Evaluation (IHME). Findings from the Global Burden of Disease Study 2017. Seattle, WA: IHME, 2018. 2. Institute for Public Health (IPH). National Health and Morbidity Survey 2011 (NHMS 2011). Vol. II: Non-Communicable Diseases. Kuala Lumpur: Ministry of Health Malaysia; 2011. ISBN 978-967-3887-68-2. 3. Institute for Public Health (IPH), National Institutes of Health, Ministry of Health Malaysia. 2020. National Health and Morbidity Survey (NHMS) 2019: Vol. I: NCDs – Non-Communicable Diseases: Risk Factors and other Health Problems 4. Department of Statistics Malaysia https://www.dosm.gov.my/v1/index.php?r=column/cthemeByCat&- cat=117&bul_id=MDMxdHZjWTk1SjFzTzNkRXYzcVZjdz09&men Accessed 01 Aug 2020. 5. Department of Statistics Malaysia https://www.dosm.gov.my/v1/index.php?r=column/cthemeByCat&- cat=155&bul_id=c1pqTnFjb29HSnNYNUpiTmNWZHArdz09&men Accessed 01 Aug 2020 6. Ministry of Health Malaysia. 2018. National Action Plan for Healthy Kidneys (ACT-KID) 2018-2025. References PREVALENCE AND ASSOCIATED FACTORS P-83 According to the Global Burden of Disease Study 2017, the prevalence of chronic kidney disease (CKD) globally was 9.1% . Malaysia recorded a similar prevalence of 9.07% in the 2011’s National Health and Morbidity Survey . We aim to determine the current prevalence and associated factors of CKD among adults in Malaysia. CHRONIC KIDNEY DISEASE IN MALAYSIA NMRR-17-806-35765 Introduction A nation-wide, population-based, cross-sectional study was conducted in 2018 among adults aged ≥18-year-old. Total of 1,398 adults were randomly selected, using stratiﬁed cluster method. Blood for serum creatinine and random blood sugar was taken from respondents at their home by qualiﬁed staﬀ from a nearby Ministry of Health (MOH) hemodialysis unit. Urine albumin-to-creatinine ratio (uACR) was measured using a single urine sample. The estimated glomerular ﬁltration rate (eGFR) was measured with a calibrated serum creatinine using the CKD-EPI equation. CKD was deﬁned as eGFR < 60 ml/min/1.73m or the presence of persistent albuminuria if eGFR ≥ 60 ml/min/1.73m . Material and Methods A total of 1398 individuals were approached for this study, and 75% of them (n = 1047) consented to participate. Serum creatinine was measured in 977 respondents. The ﬁnal analysis set comprised of 890 respondents. Table 1 shows the prevalence of CKD by stages (n = 890). Our study shows that the prevalence of CKD in Malaysia was 15.48% (95% CI: 12.30, 19.31). Using multivariate analysis, as seen in Table 2, shows that hypertension (aOR 3.72), diabetes mellitus (aOR 3.32), increasing Body Mass Index (aOR 1.06), and increasing age (aOR 1.06) were signiﬁcantly associated with CKD. Results This study has demonstrated a rising prevalence of CKD in Malaysia over the last 7 years since the previous study, the prevalence of 9.07 in 2011 to 15.48% currently. The probable reasons accounting for this rising trend are the increasing prevalence of non-communicable diseases that is associated with CKD and changes in population demographics. National Heal


Study of radon background in the SuperNEMO demonstrator • 𝜷𝜷𝟎𝝂Source foil: 𝟔. 𝟏𝟏𝒌𝒈of 82𝑺𝒆 with 𝑄𝛽𝛽~ 3 𝑀𝑒𝑉 • Tracker: 2034 Geiger cells • Calorimeter: 712 Optical Modules (OMs : Plastic scintillators + PMTs) • Copper coil for magnetic field 𝑩 Anti-radon strategy Anti-radon strategies: • Material screening for radiopurity ➔very low Rn emanation • J-Trap facility ➔ultra high Rn purification of the gas (He+Ar) • Anti-Rn tent ➔Buffer volume against the air from the LSM lab • Anti-Rn factory ➔to inject Rn-free air in the tent 222Rn decay to 214𝐁𝐢(Qβ−= 3.272 MeV) →background for 0νββ search Measuring Rn activity ⟺measuring BiPo activity Golden 214Bi-214Po channel: 1 electron + 1 delayed alpha (T214Po = 164 μs) Efficiency selection of 3.1% From 106 events simulated on the surface of the grounds wires Objectives • To optimize the BiPo selection criteria with high statistics • To study the spatial radon uniformity in the detector • To study the radon residence time in the detector Top view of the e- vertices distribution from the selected BiPo events →Spatial Rn uniformity in the bulk of the tracker →Small side effects and left-right asymmetry under study → Radon and the tracker gas mixture have the same flow dynamics Real BiPo event Time between 𝒆−𝐚𝐧𝐝 𝜶 →Increasing the gas flow by a factor 2 decreases the BiPo rate by a factor 𝐑≈2 as expected SuperNEMO Demonstrator • Goal of SuperNEMO : to search for 0𝜈ββ process with 82Se (Qββ~ 3 MeV) • Sensitivity: T1/2 0ν > 5.7 × 1024 years (17.5 kg.y exposure with 82Se ) • Able to track and measure electron energy independently • Data taking in autumn 2024 Measuring radon activity with 214Bi-214Po decay events Radon background Dedicated radon injection runs Antoine Lahaie, Mathis Granjon, Frédéric Perrot, Yegor Vereshchaka, on behalf of the SuperNEMO collaboration Radon source • Emanation rate: 95 ± 5 Rn atoms per second • Injected in the tracker at 5 L.min-1 Two Rn measurements performed at 5 and 10 L.min-1 c:-( c:-( Ar He Alcohol J-trap Emanation Diffusion ~ 0.15 mBq. m−3 ~ 30 mBq. m−3 Gas mixture Anti-radon factory Laboratory air ~ 30 Bq. m−3 Rn-free air Anti-radon tent New Radon activity updated soon with anti-radon factory, gas purification and nominal gas flow at 20 L.min-1, stay tuned ! • 58 h of Rn background measurement in March 2024 at different gas flow →Consistent with the expected value: →Radon (Rn) is the main background in the tracker Gas + Rn 𝑅= 2.3 ± 0.2 • Electron identification: ➢1 OM triggered ➢≥ 1 associated Geiger cell near the OM ➢Temporally correlated with the OM • Alpha identification: ➢≥ 2 close Geiger cells triggered ➢Delayed alpha below 1.6 µs after electron ➢Short track (≤ 12 Geiger cells ) (He + Ar gas)  Vertex OM Electron Alpha Signal Background noise selection Additional BiPo selection: 82Se source foil OM 𝜶 𝒆− ➢See SuperNEMO poster #451 Electron energy >300 keV e−/α vertex distance in xy plane ≤6 cm e−/α vertex distance on z axis ≤10 cm Delay between α and e−track [300-1600] µs τeff fit = 1.43 ± 0.14 days Measurement of the Rn residence time with gas flow at 5 L.min-1 τeff = 1 ϕ V + 1 τ = 1.54 days Gas only T = 168 ± 8 μs →fully consistent →First Rn background activity in current operation mode at 10 L.min-1 : [10-15] mBq.m-3 ✓ ✓ #41


Figure 1: Schematic diagram of the PGNAA experimental facility Neutron Radiography using isotopic neutron sources: Preliminary results S. Kolovi1,2, T.J. Mertzimekis2, I.E. Stamatelatos1, K. Bouchra3, Z. Dimitrakopoulou3 1 Institute of Nuclear and Radiological Sciences, Energy, Technology & Safety, NCSR "Demokritos” 2 Dept. of Physics, University of Athens 3 Dept. of Computed Tomography, General Hospital of Nikaia “Agios Panteleimon” INTRODUCTION Neutron Radiography (NR) is an imaging method based on the neutron attenuation properties of the imaged object. To produce an image a source of neutrons, a collimator to shape the emitted neutrons to a mono-directional beam, an object and a method of detecting neutrons are required. The present work is a preliminary study aiming to investigate the potential of Neutron Radiography using (a, n)-type isotopic neutron sources. As an application, NR images of a portable NaI scintillation detector and common computer components (CC) were acquired. The parameters that should be taken into account for the design of NR system based on (α, n) type sources are discussed. In addition, the NaI detector was examined with X-ray Computed Tomography (CT) to compare the two imaging techniques on their efficiency as diagnostic tools for such instruments. CONCLUSIONS x The results of the study suggest that neutron imaging can be performed using an isotopic (α, n) type neutron source and an IP (imaging plate) with Gd2O3 surface layer . x Requirement for a successful image is a well collimated and moderated neutron beam. x The thermal-neutron fluencies that can be achieved from isotopic source assemblies are low and can only be used for applications in which high resolution and short exposure times are not required. x Nevertheless, a significant advantage of this approach is the overall simplicity and cost effectiveness due to the long half-life of (α, n) type neutron sources. x Future work will be directed towards a trade-off study between source intensity, neutron collimation and moderation, as well as radiation shielding requirements, in order to achieve a given image resolution. REFERENCES  Neutron Imaging: A Non - Destructive Tool for Material Testing, IAEA - TECDOC - 1604, ISBN 978 - 92 - 0 - 110308 - 6  Practical Neutron Radiography , J. C. Domanus, ISBN 0 - 7923 - 1860 - 9  Bio-Imaging Analyzer BAS1500 IP Reader (Fujifilm) Operation Manual  N. Chankow et al., Applied Radiation and Isotopes, 68, 662 - 664, (2010) Computer Components NR NaI Detector NR - CT Sample Cadmium Moderator Δt (min) Figure Floppy drive / Graphics card + - 60 5 i + + 60 5 ii - + 38 NaI 6 i + - 60 - + + 60 6 ii - + 120 6 iii + - 210 7 ii + + 210 6 iv / 7 i EXPERIMENTAL SETUP & METHODOLOGY RESULTS Figure 6: NR with slow neutrons i) Δt = 38 min ii) Δt = 60 min iii) Δt = 120 min iv) Δt = 210 min The Cadmium reference sheet is marked in the picture. Figure 7: i) NR with thermal neutrons Δt = 210 min ii) NR with fast neutrons Δt = 210 min iii) CT ( X - Rays) The Cadmium reference sheet is marked in the picture. NaI Detector NR NR vs. CT in the case of NaI detector The initial aim of the irradiation of the portable NaI detector was to detect any defects or cracks in the crystal. The NR image with thermal neutrons (Fig. 7i) is of higher resolution in comparison to the one with fast neutrons (Fig. 7ii), whereas Fig. 7ii has a better image quality. No significant structural defects were detected with NR. The CT image (Fig. 7iii) offers the greatest resolution and image quality in the minimum exposure time. No defects were detected either. Dimensions of the NaI crystal (known) agree with the measurements taken from Fig. 7i and Fig. 7iii. iii Fast vs. Slow neutrons For the same exposure time, the NR image obtained with fast neutrons (no moderator) is of higher quality in comparison to the one obtained with slower neutrons (5 cm moderator) in the case of the computer compo- nents. CC consist mainly of metal parts. The effect of exposur


Characterising contrast response functions using salience-matched achromatic and chromatic Gabor patches Joel T. Martin1, Zoé Darrasse1,2 and Jasna Martinovic1 1 School of Philosophy, Psychology and Language Sciences, University of Edinburgh 2 Neuropsychology and Clinical Neurosciences, University Paul Sabatier Toulouse III Background • The human visual system processes achromatic and chromatic information in distinct parallel pathways (L+M; L-M; S- [L+M]). • Visual evoked potentials to chromatic and luminance stimuli differ in morphology and with respect to stimulus contrast (Porciatti et al., 1999). • Here we present the beginnings of a normative dataset characterising contrast response functions to salience-matched chromatic and achromatic Gabors. Experiment • 31 participants; chromatic (L-M; S-[L+M]) and achromatic (luminance: L+M) Gabors (±2σ = ~3.65 dva; SF = 0.8 cpd) with 4 logarithmically spaced contrast levels (Ach: 3.9—26%; RG: 2.5—14.3%; BY: 13.5—57.7%); task: respond to horizontal stimuli. • Heterochromatic flicker photometry was used to ensure isoluminance of chromatic stimuli. • Normal colour vision was established with the Cambridge Colour Test (CCT). • Asymmetric matching (L+M or S-[L+M] matched to L-M contrasts) to verify if salience was indeed equated across mechanisms. • Stimuli and their LMS coordinates are shown below. Results • All participants provided CCT scores within the normal limits for colour vision. • The stimulus matching procedure demonstrated close agreement between our participants. Their data generally fell close to the standards selected for the EEG experiment. Conclusion • Chromatic and achromatic VEP morphology is consistent with previous findings (Porciatti et al., 1999; Ellemberg et al., 2001). • These data are the beginnings of a normative data set that will eventually be used for control comparisons in a large-scale study on visual function in individuals with bipolar disorder (Roguski et al., 2024). HELIOS-BD Scan QR code to learn more about the HELIOS-BD project (226787/Z/22/Z). • Overall scalp topographies and EEG responses to chromatic and achromatic stimuli are shown below for all electrodes. • VEP amplitudes for each condition were fit using the Naka-Rushton equation (Naka & Rushton, 1966) to estimate the overall shape of the contrast response functions. Contact joel.martin@ed.ac.uk zoe.darrasse@gmail.com j.martinovic@ed.ac.uk References • Ellemberg, D., Hammarrenger, B., Lepore, F., Roy, M. S., & Guillemot, J. P. (2001). Contrast dependency of VEPs as a function of spatial frequency: the parvocellular and magnocellular contributions to human VEPs. Spatial vision, 15(1), 99-111. • Naka, K. I., & Rushton, W. A. (1966). S‐potentials from luminosity units in the retina of fish (Cyprinidae). The Journal of physiology, 185(3), 587-599. • Porciatti, V., & Sartucci, F. (1999). Normative data for onset VEPs to red-green and blue-yellow chromatic contrast. Clinical Neurophysiology, 110(4), 772-781. • Roguski, A., Needham, N., MacGillivray, T., Martinovic, J., Dhillon, B., Riha, R. L., ... & Smith, D. J. (2024). Investigating light sensitivity in bipolar disorder (HELIOS-BD). Wellcome Open Research, 9. L-M S-(L+M) Scan for link to online poster. • Grand average VEP are shown above for electrodes Pz, Oz, O1, O2, Iz. Achromatic-driven contrast VEPs are characterised by a robust P1 component that saturates at higher levels of contrast, followed by a non-contrast dependent N1 component. Chromatic Gabors elicited a single, strong negative deflection whose amplitude and latency depend on stimulus contrast more linearly. Grey regions were selected for calculation of N1 and P1 mean amplitude responses. P1 N1 N1 N1 Amplitude L+M Amplitude Amplitude Global field power Amplitude Amplitude Amplitude Amplitude Amplitude Lum/4 Lum/3 Lum/2 Lum/1 LM/4 LM/3 LM/2 LM/1 S/4 S/3 S/2 S/1


Open, Metadata-Enriched, Non-Proprietary Data Format for Data Dissemination Claudia Saalbach, Xiaoyao Han • Proprietary data formats jeopardize the principle of FAIR • To reach a wider user group, data producers provide the same data in various formats, resulting tin higher costs. • Different data formats, which are only partially compatible, represent an obstacle for the replication studies • Metadata in pdf or in a web-based information system are inconvenience to use Why do we need open data format? Add your information, graphs and images to this section. Speciﬁcation As part of the NFDI, KonsortSWD is expanding its services for research with data in the social, educational, behavioral and economic sciences. The mission is to develop – strengthen, widen, deepen – a research data infrastructure for the study of human society. KonsortSWD’s RDM strategy aims to - provide researchers and research data centres (RDCs) with the tools and services they need for managing and sharing (new) sensitive and non-sensitive data in accordance with the FAIR principles. - support sustainable RDM in all phases of the research data lifecycle. NFDI- KonsortSWD The open, metadata-enriched, non-proprietary data dissemination format(OpenDF) is a project of KonsortSWD, the NFDI consortium for the social, behavioural, educational and economic sciences. The project provides a non-proprietary Open Data Format enriched with multi-level metadata that is smoothly usable with popular statistical software. The goal of the project Open Data Format: Speciﬁcation data.zip metadat a.xml data.csv metadata.xml data.csv bap87,bap9201,bap9001,bap9002,bap9003,bap96 ,name 4,-2,1,-1,2,-2,Jakob 3,5,-2,1,4,1.57,Luca ,-1,-1,2,-1,1.92,Emilia 1,9,-2,2,4,1.85,Charlotte -1,4,2,3,1,1.91,Johanna 3,4,-1,4,-2,1.8,Paul 1,9,2,-1,-1,1.8, 5,6,1,-1,1,1.96,Mia 5,5,5,3,1,1.64,Ben -2,4,4,-1,-2,1.93,Jakob <dataDscr> <var name="bap87"> <labl xml:lang="en">Current Health</labl> <labl xml:lang="de">Gesundheitszustand gegenwärtig</labl> <txt xml:lang="en">Question: How would you describe your current health?</txt> <txt xml:lang="de">Frage: Wie würden Sie Ihren gegenwärtigen Gesundheitszustand beschreiben?</txt> <notes> <ExtLink URI="https://paneldata.org/soep-core/data/bap/bap87"/> </notes> … data.zip Stata R SPSS Use case: R package DIW Berlin: www.diw.de SOEP: https://www.diw.de/en/diw_01.c.615551.en/research_infrastructure__socio-economic_panel__soep.html Project: KonsortSWD - Consortium for the Social, Behavioural, Educational and Economic Sciences in the National Research Data Infrastructure (NFDI)


Modelling Solar Ca II H&K Emission Variations K. Sowmya, A. I. Shapiro, V. Witzke, N.-E. Nèmec, T. Chatzistergos, K. L. Yeo, N. A. Krivova, S. K. Solanki Max Planck Institute for Solar System Research, Göttingen, Germany EU Grant No. 797715 (IMagE) • Depending on the inclination and period of observations, the activity cycle in solar S- index can appear weaker or stronger (as shown by the red symbols in Figure 3) than in stars with a solar-like level of magnetic activity. • Solar chromospheric emission variation is absolutely normal in comparison to other stars with near-solar magnetic activity. Figure 1: Validation of our model calculations (orange) against the ground-based solar observations (corresponding to i~90°; black). Panel a - daily values; panel b - 81-day smoothed values. Figure 2: Inclination dependence of the S-index. 81-day averaged S-index values for solar cycles 21-23 for inclinations ranging from 90° (equator-on view; black curve) to 0° (pole-on view; purple curve). Figure 3: Chromospheric emission variations (y- axis) vs. the mean chromospheric activity (x-axis) for the Sun (black star and red symbols) and other Sun-like stars (black circles). Red symbols show our calculations. Grey shaded regions indicate the spread due to inclination and strength of the activity cycle. • We used the distributions of solar magnetic features derived from the surface ﬂux transport simulations together with the non-LTE spectra of Ca II H&K lines. • We showed that the S-index values obtained by an out-of- ecliptic observer are different from those obtained by an ecliptic-bound observer (Figure 2). • This indicates that it is important to consider the inclination effect on S-index while comparing the magnetic activity of the Sun to other stars. • The S-index quantiﬁes the emission in the near UV Ca II H&K lines and is a prime proxy of solar and stellar magnetic activity. • To study the dependence of S-index on the inclination angle (i) between the stellar rotation axis and the direction to the observer, we developed a physics-based model and validated it against the available solar S-index measurements (Figure 1). krishnamurthy@mps.mpg.de Sowmya et al. (2021), ApJ, Under review


Consensus detection and identification protocol for Acidovorax citrulli on cucurbit seeds Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 78 000 Picture 1 Picture 1 Picture 1 Goals Acidovorax citrulli (synonyms: Acidovorax avenae subsp. citrulli, Pseudomonas pseudoalcaligenes subsp. citrulli) is the causal agent of bacterial fruit blotch (BFB) of cucurbit plants, primarily watermelon and melon where significant economic losses have been reported. Once the pathogen is introduced in an area, high humidity, high temperature and overhead irrigation increase the risk of BFB epidemic development. Despite the economic importance of the disease, little is known about the basic aspects of A. citrulli epidemiology and the factors involved in its pathogenicity and virulence. Since there are no resistant commercial cultivars, successful management of BFB depends on exclusion of primary inoculum by using pathogen-free seeds and seedlings. Seed health testing reduces the risk of outbreaks. For this purpose the project has the goal to develop a consensus protocol for the detection of A. citrulli on cucurbit seeds together with the monitoring of the pest in the main cucurbit production areas. Moreover, there is an ever-growing need for multiplex, high- throughput detection methods that can be applied directly to plant parts to certify their health status. Improvement or development of new methods to distinguish accurately between bacterial strains (two groups determined currently for Acidovorax citrulli) would be beneficial in determining their emergence and evolution as pathogens. Research consortium UNIMORE (IT), ANSES (FR), BPI (GR), NFCSO (HU), CREA (IT), NVWA (NL), FGBU- VNIIKR (RU) Contact information Project coordinator: Emilio Stefani stefani.emilio@unimore.it Key outputs and results • Validated identification methods (test performance studies for detection and identification tests) • A consensus protocol for the detection of Acidovorax citrulli on cucurbit seeds 07/2016-06/2018