Figure1: SnE-VNet: A visual representation of the presented model. Figure2: Visual representation of a SnE block. Identifies important channels in the feature map. Improves performance without increasing computational cost. Enhances feature representation in 3D data. The SnE- Blocks Encoder: Downsamples the image to extract high-level features. Decoder: Upsamples the features to reconstruct the original image. Connection: Connect encoder and decoder layers to capture spatial information. Building Blocks METHODOLOGY 3D CNN-based encoder-decoder structure with squeeze and excitation (SnE)-based residual connections. AFFILIATION SnE-VNet: A Deep Learning Model with Squeeze and Excitation for Improved 3D Stroke Lesion Segmentation AUTHORS Mishaim Malik, Benjamin Chong, Justin Fernandez, Vickie Shim, Alan Wang INTRODUCTION Stroke is a leading cause of disability, affecting over 12 million people worldwide each year. Accurate lesion segmentation could help automate stroke management, treatment planning, and rehabilitation outcome prediction. MOTIVATION Deep learning offers a promising alternative to manual segmentation, which is time-consuming and requires expertise. SnE-VNet automates segmentation, improving efficiency and consistency. RESULTS Improved Ground Truth and Prediction overlap score by 1.3% & true positive rate by 4.7%. Figure3: Segmentation Results. KEY FINDINGS SnE-VNet: Segments lesions of various sizes and shapes. has the potential to help clinicians to access better an d faster results, which will expedi te stroke diagnosis and managem ent significantly . REFERENCES [1] Feigin, V. L. et al., 2022 “International Journal of Stroke”. [2] Karakis, R. et al., 2023 “Journal of Biomedical Informatics”, 141. [3] Malik, M. et al., 2024 “Bioengineering”, 11(1), 86. [1] This work was funded by the Health Research Council of New Zealand. [2] [3] Red = False Negatives Green = False Positives


4. ERGEBNISSE 5. AUSWERTUNG Die Boxplots in den oberen beiden Abbildungen zeigen jeweils für 10 und 12 Uhr die Reaktionszeiten und Genauigkeitswerte des N-Back- und des spatial work ing memory updating Test bei den jeweiligen Lichtszenen. Weder um 10, noch um 11 Uhr konnten signifikante Unterschiede bei den Audioreaktionszeiten und den Genauigkeiten zwischen den Lichtszenen nach der Exposition gefunden werden. Ein Vergleich der Mittelwerte zeigte, dass um 12 Uhr die Genauigkeits werte des spatial working memory updating Tests unter der frontalen Beleuch tung des Gesichtsfeldes (Lichtszene 1+2; M = .660, SD = .114) höher sind als unter der konventionellen Beleuchtungssituation (Lichtszene 3; M = .540, SD = .089). 6. FAZIT In dieser Studie zeigte sich kein statistisch signifikanter Unterschied zwischen den untersuchten Lichtszenen und den Reaktionszeiten oder Genauigkeitswer ten der kognitiven Leistungstests. Die Hypothese konnte nicht bestätigt werden. Die Ergebnisse beeinflussende Faktoren: Tageszeit / Chronotyp: NIF-Wirkungen tagsüber moderater ausgeprägt; cir cadianer Leistungsgang Lichthistorie: Versuchsdurchführung im Sommer - längere vorherige Tages lichtexposition als im Winter Psychologische Leistungstests: Schwierigkeitsgrad, Art der Durchführung (Laptop, Tablet, etc.) Dauer der Lichtexposition: hier nur kurzzeitige Exposition; möglicherweise nicht ausreichend für die messbare Ausprägung der NIF-Effekte 1. EINFÜHRUNG Nicht-visuelle Effekte des Lichts (englisch: non-image-forming, NIF), werden durch ein Zusammenspiel der photosensitiven Sinneszellen in der Netzhaut beeinflusst. Unter den photosensitiven Sinneszellen wird den intrinsisch pho tosensitiven retinalen Ganglienzellen (englisch: intrisically photosenitive Re tinal Ganglion Cell, ipRGC) eine besondere Rolle zugeschrieben. Direkt mit der Lichtwirkung auf diese Zellen verknüpfte Wirkungen, wie z.B. die Melatoninun terdrückung, werden auch als ipRGC-beeinflusste Lichtwirkungen (englisch: ipRGC-influenced light effects, IIL) bezeichnet. Ein gut untersuchter Zusam menhang einer IIL-Wirkung besteht zwischen der Lichtexposition und dem zeit lichen Konzentrationsverlaufs des nur während der Nacht vorhandenen Hor mons Melatonin. Einige Studien zeigen einen Einfluss der Lichteinfallsrichtung. Licht aus dem oberen Gesichtsfeld, das auf die untere Netzhauthälfte fällt, führ te zu einer stärkeren Melatoninunterdrückung. Der Einfluss der Lichteinfalls richtung auf andere NIF-Effekte während der Nacht, wie z.B. Phasenverschie bung, Körperkerntemperatur und subjektive Schläfrigkeit, wurde bisher nur von einzelnen Studien untersucht. Am Tag wurde dies noch nicht untersucht. 2. ZIEL Ziel dieser Arbeit ist zu untersuchen, ob und welcher Einfluss sich durch ver schiedene räumliche Lichtverteilungen am Tag auf kognitive Leistungstests zeigt. Konkret soll die Hypothese untersucht werden: Licht aus Region 1+2 steigert tagsüber die Genauigkeit und senkt die Reaktionszeiten der kognitiven Leistungstests. 3. METHODE In einem speziellen LED-hinterleuchteten büroähnlichen Lichtsimulatorraum der TU Berlin wurde eine Probandenstudie (N=10, w=3) durchgeführt. Dazu wurden zwei Lichtszenen eingerichtet: in der einen Lichtszene trifft das Licht hauptsächlich aus dem oberen Gesichtsfeld und in der anderen Lichtszene hauptsächlich aus dem unteren Gesichtsfeld auf das Auge des Probanden. Gemeinsam haben die Lichtszenen eine Beleuchtungsstärke von 1000 lx am Auge (Emel,v=160 µW/cm²) und einer ähnlichsten Farbtemperatur von 6200 K bei einem Farbwiedergabeindex von ca. 80 (siehe Abb. 1). Die Durchführung fand für die eine Hälfte der Probanden um 10 Uhr und für die andere 11 Uhr im Abstand je einer Woche statt. Innerhalb der beiden Gruppen wurden die Licht szenen jeweils als gegenbalanciertes Cross-Over-Design durchgeführt. Jeweils vor und nach der Lichtexposition wurde ein Fragebogen ausgefüllt und ein Audioreaktionszeittest, sowie zu Beginn und als Abschluss der Expositions zeit ei


ExaFMM: An open source library for Fast Multipole Methods aimed towards Exascale systems Lorena A Barba1, Rio Yokota2 1 Boston University, 2 KAUST Left — The simulation of homogeneous isotropic turbulence is one of the most challenging benchmarks for computational fluid dynamics. We have matched the current world record in turbulence simulation, computing a 40963 system on 4096 GPUs with our fast multipole vortex method. This simulation achieved 1 petaflop/s on Tsubame 2.0. Below — Scaling on a massively parallel CPU systems is also excellent. The plot shows MPI weak scaling (with SIMD within each core) from 1 to 32,768 processes, and timing breakdown of the different kernels, tree construction and communications. The test uses 10 miilion points per process, and results in 72% parallel efficiency on 32 thousand processes (Kraken system). GPU Technology Conference, May 2012 What’s new? An open source FMM Want more? Papers and software are online P2P M2L M2P 0 50 100 150 200 250 300 350 GFlops N=104 N=105 N=106 N=107 Left — Actual performance on the GPU of three core kernels, for four different values of N. The M2P kernel of the treecode is able to deliver more flop/s on GPU than the M2L kernel of the FMM. M2M multipole to multipole treecode & FMM M2L multipole to local FMM L2L local to local FMM L2P local to particle FMM P2P particle to particle treecode & FMM M2P multipole to particle treecode source particles target particles information moves from red to blue P2M particle to multipole treecode & FMM Results: Parallel, multi-GPU performance Besides the results shown above, strong scaling runs on CPUs for 10 million bodies per core have shown 93% parallel efficiency at 2048 cores without SIMD, and 54% parallel efficiency at 2048 cores with SIMD kernels. Strong scaling runs on GPUs for 100 million bodies show 65% parallel efficiency on 512 GPUs, while weak scaling runs on GPUs with 4 million bodies per GPU show 72% parallel efficiency on 2048 GPUs. The calculation of isotropic turbulence on a 20483 grid (as shown in the figure above) uses 4 million bodies per GPU on 2048 GPUs. The same calculation using FFTW on 2048 CPU cores of the same machine obtains 27% parallel efficinecy on 2048 cfores. The good scalability of FMMs becomes an advantage on massively parallel systems. All the codes developed in our group are free (like free beer) and open source. To download them, follow the links from our group website: http://barbagroup.bu.edu Also on the website are up-to-date bibliographic references, and papers for download. Please visit! pop stack split cell multipole acceptance criterion push to stack calculate interaction calculate interaction target tree source tree push root pair to stack Initial step Iterative step 1 8 64 512 4096 32768 0 10 20 30 40 Nprocs time [s] tree construction mpisendp2p mpisendm2l P2Pkernel P2Mkernel M2Mkernel M2Lkernel L2Lkernel L2Pkernel 1/16 1/8 1/4 1/2 1 2 4 8 16 32 64 128 256 16 32 64 128 256 512 1024 2048 Operational intensity (flop/byte) Attainable flop/s (Gflop/s) no SFU, no FMA +SFU +FMA Fast N-body (particle-particle) Fast N-body (cell-cell) 3-D FFT Stencil SpMV single-precision peak The fast multipole method (FMM) is a numerical engine used in many applications, from acoustics, electrostatics, fluid simulations, wave scattering, and more. Despite its importance, there is a lack of open community code, which arguably has affected its wider adoption. It is also a difficult algorithm to understand and to program, making availability of open-source implementations even more desirable. Method: Multipole-based, hierarchical There are two common variants: treecodes and FMMs. Both use tree data structures to cluster ‘source particles’ into a hierarchy of cells. See Figure to the right. Multipole expansions are used to represent the effect of a cluster of particles, and are built for parent cells by an easy transformation (M2M). Local expansions are used to evaluate the effect of multipole expansions on


***Este documento está clasificado como PUBLICO por TELEFÓNICA. ***This document is classified as PUBLIC by TELEFÓNICA. Providing Secure NFV Multi-Site Connectivity Services DESCRIPTION OF COMPONENTS AND ARCHITECTURE VALIDATION OF THE SCENARIO PoC TEAM MEMBERS FISHY EU PROJECT L2S platform offers an abstraction of a layer-2 switch with VLANs support that spans multiple NFV sites. In addition, it protects data communications among NFV sites using standards protocols and state-of-the-art open-source technologies (such as VXLAN, or IPsec), preserving isolated operations of multi-site NFV services. The Centrally Controlled IPSec (CCIPS) goes beyond the classical point to point IPsec setup and provides a centralized architectural solution to control multiple IPsec endpoints or gateways. This solution is composed of a centralized E2E manager (controller) and two or more agents, based on IPsec engine in IKE-less mode (no IKE protocol is needed). @H2020FISHY https://www.linkedin.com/in/fishy-project- 16342920a/ • CCIPS agents orchestrated by CCIPS controller • Data and control nodes • Encryption algorithms • Lifetimes for SA • Events • CCIPS on • Rekey • CCIPS off • Traffic increases due to the exchange of encrypted packets https://fishy-project.eu/ FISHY has received funding from the European Union’s Horizon2020 Research and Innovation Programme, under grant agreement no. 952644 Control events Data traffic (TCP)


RESULTS Eighty-two children (mean age 8.6±3.5 years) were studied between Dec-2021 to Dec-2022; 60 with a molecular-documented previous COVID-19 (Group A) and 22 without previous infection defined as the absence of antigen-specific antibodies before the vaccination (Group B). Overall, 44 were healthy children (HC), 20 were immune compromised (IC), and 18 had a previous diagnosis of MIS-C (MIS-C). Title: mRNA vaccine elicits a higher humoral response in children with a previous COVID-19 with an overall median S-RBD IgG, Parental, and Omicron NAbs in Group A 5, 18, and 28-fold higher than Group B (p<0.0001) (Fig.1) Costanza Di Chiara1,2§, Anna Cantarutti3§, Francesco Bonfante4, Maria Raffaella Petrara1, Chiara Cosma1, Matteo Pagliari4, Nicola Cotugno5, Alessandra Meneghel1, Elisa Benetti1, Luca Bosa1, Paolo Palma5, Anita De Rossi1, Carlo Giaquinto1,2, Daniele Donà1,2§, Andrea Padoan1§, for the VERDI study team mRNA Vaccines Induce a Higher Antibodies Response in Children With Previous COVID-19 CONCLUSIONS We observed that mRNA vaccination triggers a higher humoral response in children with a previous history of COVID- 19, regardless of the immune deficiency or previous MIS-C, providing insight into boosting preexisting immunity with mRNA vaccines. Moreover, antibodies declined from 1 to 6 mo after vaccination in both groups. 0841 BACKGROUND mRNA vaccines trigger an higher magnitude and durability of humoral response to SARS-CoV-2 in adults after a previous infection compared to infection- naïve people. However, data are lacking in the pediatric population. This study aimed to evaluate the early and long-term immune response after the BNT162b2 monovalent vaccine in children aged 5-11 years with or without a previous SARS-CoV-2 infection. METHODS Multi-centre, prospective, observational study evaluating the immune response to SARS-CoV-2 in children aged 5-11 years attended the Pediatric Departments at the University of Padua and Bambino Gesù Children’s Hospital in Rome (Italy); Volunteers underwent three immunological follow-up (pre-vaccination and 1 month (mo), and 6 mo after the second dose); a blood sample was collected during each visit for the characterization of the immune profile; Neutralizing antibodies (Nabs) and anti-S-RBD IgG titers were analyzed through Plaque Reduction Neutralization Test (PRNT) and chemiluminescent immune-enzymatic assay (CLIA), respectively. B and T cell phenotypes were analyzed by flow cytometry; Geometric mean titers (GMTs) and 95% CI and median and IQR of variables were evaluated according to pre- existing confirmed COVID-19. §contributed as co-first and co-last authors 1 University of Padova, Padova, Italy; 2 Penta – Child Health Research, Padova, Italy; 3 University of Milano-Bicocca, Milan, Italy; 4 Istituto Zooprofilattico Sperimentale delle Venezie, Padova, Italy; 5 Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy. Fig.1 Fig.2 Panel A Panel B Panel C 0 1000 2000 3000 4000 5000 6000 1 mo. 6 mo. S-RBD IgG kBAU/L Median Time from Vaccine Healthy IT MIS-C Healthy IT Group A Group B 0 1000 2000 3000 4000 5000 6000 7000 1 mo. 6 mo. Reciprocal of PRNT50 (Parental) GMT Time from Vaccine Healthy IT MIS-C Healthy IT Group A Group B 0 100 200 300 400 500 600 700 800 900 1000 1 mo. 6 mo. Reciprocal of PRNT50 (BA.2) GMT Time from Vaccine Healthy IT MIS-C Healthy IT Group A Group B Fig.2 Similarly, T-regs and B-regs were higher in Group A than B at 1 (p<0.01) and 6 months (p<0.02). Among HC, IC, and MIS-C in Group A, comparable antibodies titers at 1 mo (S-RBD p=0.37, Parental NAbs p=0.38, Omicron NAbs p=0.83) and antibodies decay of 50-70% between 1 and 6 mo were observed. Similarly, an analogous decrement of antibodies was recorded among HC and IC in Group B (S-RBD p=0.60, Parental NAbs p=0.71, Omicron NAbs p=0.42) (Fig.2). ADDITIONAL KEY INFORMATION Author contact details: costanza.dichiara@phd.unipd.it Acknowledgements:


In the UK, approx. 25% of people registered with a GP are living with multimorbidity: having more than one long-term condition: e.g. diabetes, heart disease and dementia1. This is expected to become more common2. People from deprived backgrounds are worse affected, and more likely to have multiple conditions at younger ages1. Doctors and researchers are working to improve the health and care of people with multiple diseases. However, we also need to prevent people from developing multiple conditions. Many chronic diseases are partly caused by diet and how much we smoke, drink, and exercise. The societies we live in influence these ‘lifestyle choices’. Strategies to prevent long-term diseases can therefore focus on changing individual behaviour or the conditions around us. Background People with multiple conditions tend to have worse health, may have to take multiple medications, and often have many appointments with different doctors and nurses They are also more likely to have difficulties with mobility and daily activities, particularly in old age3. Multimorbidity is also a problem for the NHS, which is centred on care for specific individual diseases, making it hard to manage the care of patients with multiple conditions4. Estimating which strategies are most likely to stop people developing multiple conditions will help policy makers assess the different options. Predicting how many people may be living with multimorbidity in different scenarios can also inform the planning of services for future health and social care needs. Why is this topic important? Using data from 2004-2018 on 1m GP patients in England (from the Clinical Practice Research Datalink), we will estimate: • The number of people who are living with multiple conditions, and diagnosed each year • How diseases accumulate over the life-course: • How age, sex, and deprivation affect the above results What are the trends over time and how are different people affected? • There are many definitions of “multimorbidity”, e.g. having 2+ conditions lasting over 1 year, or including only certain diseases. Different definitions help to answer different questions, and healthcare workers and patients may have different priorities. • We aim to develop a definition of multimorbidity relevant for prevention, taking into account risk factors for disease and combining what is important for patients, healthcare workers, and the NHS. How should we define multimorbidity for prevention? • We will use a model (IMPACTNCD 5) to compare the effectiveness of different potential individual-level and structural prevention strategies. • A key component will be estimating which strategies are fairest to people living in the most deprived areas. • Examples strategies include structural policies on food e.g. marketing regulation or taxation; and individual level strategies e.g. NHS health checks and screening. What might help stop people developing multiple conditions? How can we reduce the future number of people living with more than one long-term health problem? Anna Head, Martin O’Flaherty, Kate Fleming, Chris Kypridemos Department of Public Health and Policy, University of Liverpool This project is funded by the University of Liverpool and supported by the National Institute for Health Research (NIHR) School for Public Health Research (Grant Reference Number PD-SPH-2015-10025). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Overall Aim: To look at whether and by how much we can stop people from developing multiple long-term conditions and what might be the best ways of doing this. Throughout, we will focus on whether and how people from more deprived areas of England have been or would be worse affected. We have 3 main research questions: Time to 2nd Time with multimorbidity Time to 1st disease Age Disease-free 1 disease 2 diseases 3+ REFERENCES: [1] Barnett et al. 2012. Epidemiology of multimorb


Canonicalized systematic nomenclature in chemoinformatics And some new canonicalization tools from OpenEye Jeremy J. Yang 3600 Cerrillos Road Suite 1107 Santa Fe, New Mexico 87507 505.473.7385 info@eyesopen.com www.eyesopen.com Introduction Canonicalization in chemoinformatics facilitates rigorous, unambiguous expression and handling of chemical data and knowledge. However, just as chemistry encompasses multiple levels of abstraction and modelling, no single canonicalization method is sufficient to solve all problems. This study reviews some existing canonicalization methodology and describes new methods implemented by chemoinformatics library OEChem and other OpenEye tools. Aha! -- Chemo-taxonomy is a “stranded hierarchy” The Morgan algorithm was a huge step forward, but the basic algorithm has some shortcomings, in performance and comprehensiveness, which have been corrected by subsequent investigators. The resulting methods have been implemented and widely used in large scale database systems. Some key contributions: • Morgan, 1965 à note to Harry: “You da man!” à CAS • Wipke & Dyott, 1974 à stereo-enhanced Morgan à MDL • Jochum & Gasteiger, 1977 à Morgan refinement à CACTVS • Shelley & Munk, 1977 à Morgan refinement • Weininger, 1988 à CANSMI canonical line notation à Daylight • Bradshaw, 1998 à parent compounds à GSK,Daylight • Delany & Sayle, 1999 à tautomers à OpenEye • INChi, 2004 à global canonical line notation Fig 2: Morgan slow due to symmetry. 1. Morgan, H. L., "Generation of a unique machine description for chemical structures - A technique developed at Chemical Abstracts Services", J. Chem. Doc. 1965, 5, 107. 2. Stereochemically unique naming algorithm, W. Todd Wipke, Thomas M. Dyott; J. Am. Chem. Soc.; 1974; 96(15); 4834-4842. 3. Canonical Numbering and Constitutional Symmetry, Clemens Jochum and Johann Gasteiger, J. Chem. Inf. Comput. Sci.; 1977; 17(2); 113-117. 4. Computer Perception of Topological Symmetry, Craig A. Shelley, Morton E. Munk; J. Chem. Inf. Comput. Sci.; 1977; 17(2); 110-113. 5. An Approach to the Assignment of Canonical Connection Tables and Topological Symmetry Perception, Craig A. Shelley, Morton E. Munk, J. Chem. Inf. Comput. Sci.; 1979; 19(4); 247-250. 6. David Weininger, Arthur Weininger and Joseph L. Weininger, "SMILES 2: Algorithm for Generation of Unique SMILES Notation", Journal of Chemical Information and Computer Science (JCICS), Vol. 29, No. 2, pp. 97-101, 1989. 7. A beginner's guide to responsible parenting or knowing your roots, www.daylight.com/meetings/emug98/Bradshaw/, EuroMUG '98, Cambridge, UK, Oct 1998. 8. Canonicalization and Enumeration of Tautomers, Jack Delany and Roger Sayle, www.daylight.com/meetings/emug99/Delany/taut_html/sld001.htm EuroMUG '99, Cambridge, UK, Oct 1999. 9. Hooked on Protonics, Roger Sayle and Geoff Skillman, www.eyesopen.com/about/events/presentations/acs02/sld001.htm, 224th ACS National Meeting, Boston, Aug 2002. 10. Introduction to Chemical Info Systems, John Bradshaw, www.daylight.com/meetings/emug02/Bradshaw/Training/, Euromug02 24th-26th September 2002, Cambridge UK 11. That INChIFeeling, www.reactivereports.com/40/40_3.html, Reactive Reports, Sep 2004 (issue 40) 12. OEChem, OpenEye Scientific Software, 2002. 13. QuacPac, OpenEye Scientific Software, 2004. References • subatomic à atoms à molecules • normal weight atoms à isotopes • Kekule molecule model à aromatic molecule models • non-stereo molecule à stereoisomers • single molecule à combinatorial libraries • single molecule à queries • small molecule à macromolecule + cofactors + ligands • single molecule à Markush structures • single molecule à tautomer set • single molecule à pKa states • single molecule à reactions • 2D à 3D There is a hierarchical relationship among some of these expansions while some are independent. For example, combinatorial library may involve stereoisomeric individuals or non-stereo. For every combination of molecular representations, ca


Center fo Innovativ CERTIFICATE OF A This certificate is presente Amel Beganovic For having successfully com "Summer Coding School 202 Blazor basics and applic Dragan Pepic Pr The course mentor Ce or Application of New a ve Technologies - NIT APPRECIATION ed to c mpleted training: 20" cations rof. dr Semsudin Plojovic enter NIT CEO CE DA DO and RTIFICATE ID:Blazor2020/1.9 ATE OF ISSUE: 20.10.2020. OI: 10.6084/m9.figshare.13125287


Literature cited 1 Webster, M. S., Marra, P. P., Haig, S. M., Bensch, S. & Holmes, R. T. Links between worlds: unraveling migratory connectivity. Trends in Ecology & Evolution 17, 76–83 (2002). 2 Faaborg, J. et al. Long-term decline of a winter-resident bird community in Puerto Rico. Biodiversity and Conservation 22, 63–75 (2013). 3 Bouten, W., Baaij, E. W., Shamoun-Baranes, J. & Camphuysen, K. C. J. A flexible GPS tracking system for studying bird behaviour at multiple scales. J Ornithol 154, 571–580 (2012). 4 Ambrosini, R., Møller, A. P. & Saino, N. A quantitative measure of migratory connectivity. Journal of Theoretical Biology 257, 203–211 (2009). Acknowledgements & Funding We thank M. van den Tillaart and L. Meczarski of Lotek Wireless Inc. who provided technical support. This research was supported by grants from the Smithsonian Institution’s Competitive Grants Program for Science awarded to M.T.H and P.P.M, and the National Science Foundation. Miniaturized GPS Tags Identify Non-breeding Territories of a Small Breeding Migratory Songbird Michael T. Hallworth & Peter P. Marra Migratory Bird Center, Smithsonian Conservation Biology Institute, Washington, DC 20008 Migratory Connectivity Project - Introduction - Ovenbird with PinPoint-10 GPS tag Current knowledge of when and where migratory animals go throughout their annual cycle, i.e. migratory connectivity, is highly limited1. Yet this information is urgently needed given that many songbird species are exhibiting significant population declines2. Unfortunately, identifying locations of individuals during subsequent periods of the annual cycle, such as on the non- breeding grounds with high spatial resolution, has been only possible with large-bodied species (e.g., mammals, raptors, seabirds). Here, we tested and deployed a newly developed miniaturized tracking device that weighs ~1 g, combines archival technology with GPS accuracy (~10 m) and can be placed on small songbirds weighing <20 g. Until now, the smallest comparable device available was ~12 g and could only be placed on animals weighing at least 250 g3. Newly developed PinPoint-10 GPS tag which weighs ~1g and has ~10m accuracy Objectives 1) Identify non-breeding territories of Ovenbirds captured while breeding within two widely separated populations (~2000 km). 2) Characterize the environmental attributes of non-breeding territories using remote sensing. 3) Quantify the strength of migratory connectivity. - Methods - We deployed archival GPS tags on Ovenbirds (Seuirus aurocapilla) during the 2013 breeding season (May-June) at Hubbard Brook Experimental Forest, NH (n = 24) and Jug Bay Wetland Sanctuary in MD (n = 24). We attempted to re-capture the Ovenbirds the subsequent year to recover the GPS tags and download the data. The GPS tags were scheduled to take location information every 28 days from 1 July 2013 until 10 Mar 2014. Environmental Attributes Remote sensing was used to quantify the following non-breeding attributes: -Elevation (m) -Distance to coastline (km) -Vegetation cover (%) Migratory connectivity A Mantel test (rM) was used to determine the strength of migratory connectivity4. rM Values close to 1 indicate a strong correlation between breeding and non-breeding distance matrices (i.e., individuals breeding in close proximity also winter in close proximity). - Results - Non-breeding territory attributes Hubbard Brook Exp. Forest, NH n = 5 Jug Bay Wetland Sanctuary, MD n = 10 Difference (95 % CI) Elevation (m) 282.66 (195.68 : 367.88) 38.75 (16.33 : 45.47) 243.91 (154.61 : 332.13) Distance to Coastline (km) 17.27 (7.26 : 28.46) 24.40 (10.08 : 39.33) 7.13 (−10.94 : 24.70) High Vegetation Cover (%) 0.296 (0.08 : 0.56) 0.270 (0.13 : 0.41) 0.026 (−0.32 : 0.22) We recovered 15 GPS tags in 2014 (NH: n = 5, MD: n = 10). Ovenbirds breeding in New Hampshire wintered primarily on the island of Hispaniola, while birds breeding in Maryland wintered in Cuba and Florida (Fig. 1). Overall, Ovenbirds exhibited stron


POBREZA EXTREMA POLÍTICAS Y REPRESIÓN AYUDA HUMANITARIA RESTRICCIONES DE DERECHOS ¿QUÉ ESTÁ PASANDO? IMPORTANCIA DEL AUTOCUIDADO 97% de la población vive en la pobreza. La pobreza ha aumentado desde el 47% en 2020. Matrimonio precoz y venta de órganos como opcione s desesperadas. La ayuda no cubre las necesidades básicas. La congelación de reservas y el recorte d e ayuda s limita n la economía. En 2022, la ayuda fue mayorment e humanitaria , evitan do hambrunas. Libertad de expresión suprimida y medios de comunicación restringidos. Aumento de ejecuciones públicas y empeoramiento de la situación de minorías. Refugiados y desplazados enfrentan graves dificultades. SITUACIÓN DE LAS MUJERES Cierre del Ministerio de Asuntos de la Mujer y creación del Ministerio de Propagación de la Virtud. Nuevas leyes restrictivas y código de vestiment a para mujeres. Arrestos de mujeres que protestan por su s derechos. Los tribunales para investigar violencia d e géner o est án cerrados. Las mujeres que denuncian violenci a so n castigada s po r l as autoridades. VIOLENCIA DE GÉNERO NORMAS Y DECISIONES PROVIENEN DEL PROPIO INDIVIDUO LA OPRESIÓN Y VIOLENCIA LIMITAN LOS DERECHOS DE LAS MUJERES AFGANAS ESENCIAL PARA EJERCER DERECHOS Y TOMAR DECISIONES INFORMADAS DIFICULTADES ECONÓMICAS IMPIDEN EL EMPODERAMIENTO CAPACIDAD DE ACTUAR EN FUNCIÓN DE ASPIRACIONES Y DESEOS NECESIDAD DE FOMENTAR LA EDUCACIÓN Y CREAR ESPACIOS SEGUROS PARA LA EXPRESIÓN Y EL APRENDIZAJE DERECHOS HUMANOS EN AFGANISTÁN AUTONOMÍA DESAFIOS Afganistán enfrenta una crisis humanitaria y de derechos humanos severa, exacerbada por la pobreza extrema y el control talibán. EDUCACIÓN Y TRABAJO Prohibición de estudiar y trabaja r fuer a de l hoga r des de diciembre de 2022. Exclusión de la vida pública pone e n peligro la salud, vida y dignid ad de las mujeres. Estudiante de Trabajo de Fin de Grado: Carlos Loor Millán Tutora del Trabajo de Fin de Grado: Sonia Verdugo Castro


Abstract Behavioral science can be accelerated greatly by the use of digitally controlled devices capable of measuring relevant parameters and, if necessary, interact with the experiment. Those machines can be bought and they can do things in an implemented way. They are however neither cheap nor as adaptive as they should be. The focus of this poster is to demonstrate how to overcome the rather small barriers in order to develop their own machines. Recently, open hardware projects like the Arduino or the Raspberry Pi draw enormous community coding and building elements that can be fused together to fit the experimenters needs. We as scientists can benefit from large numbers of projects that are documented well in the internet, mostly by tutorial videos including component lists and code. Here we present a number of simple suggestions how to build yourself helpful devices for your behavioral and neurophysiological experiments. inputs: brightness color temperature ultrasonic sound magnetic field capacities moisture humidity contact liquids camera and a lot more... computing: Arduino (microcontroller) models: Uno, nano, mega ... - USB interface - 6 – 16 ADCs - easy to use Raspberry Pi (processor) models: 1, 2, 3, zero - +/- 1 GB RAM / 4x 1,2 GHz - OS (Linux) / GUI - LAN / WiFi / BT - on board - display output data analysis / storage: files, tables, matricies for: MS Excel, R, Statistica,... MatLab, SimuLink Python and a lot more... outputs: motors light sound display LAN WiFi Bluetooth RF serial/USB (PC) Memory (SD) and a lot more... Benjamin H Paffhausen, ben@paffhausen.org, Department of Neurobiology, Freie Universität Berlin, Germany Low cost open source hardware and software in behavioral and electrophysiological experiments: Arduino & Raspberry Pi The MIT License (MIT) Copyright (c) <year> <copyright holders> Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. power supply: battery (5 – 24 V DC) powersocket (220 V AC) PC – USB (5 V DV) solar knowledge base: (find code and pinout) forum.arduino.cc stackexchange.com github.com learn.adafruit.com youtube.com communities: (ask questions) forum.arduino.cc raspberrypi.org/forums stackexchange.com github.com researchgate.net reddit.com availability: (where to buy) arduino.cc raspberry.org adafruit.com ebay.de conrad.de mouser.com necessary skills: - solid experience with searching the Internet for information - very basic understanding of physics and electronics - soldering (optional) what you will learn: - organize projects (develop from the glimmer of an idea to a device) - technical understanding of the possibilities and limits of devices that can support behavioral research. Be at the cutting edge! - using the swarm intelligence of the Internet how to start: - buy an Arduino - download Arduino IDE - connect Arduino via USB - open sketch blink - load it up to the Arduino - see the onboard LED blink - play with the code learn programming: (IMHO) The easiest way to learn programing is to start with a hardware based project. Analy


ПСИХОЛОГІЧНИЙ СТАН МЕДИЧНИЙ ПРАЦІВНИКІВ ПІД ЧАС ПАНДЕМІЇ COVID-19: МЕТА-АНАЛІЗ Мета: оцінити дані психологічного стану медичних працівників в умовах пандемії COVID-19 у порівнянні зі спеціалістами немедичних спеціальностей. Мета: оцінити дані психологічного стану медичних працівників в умовах пандемії COVID-19 у порівнянні зі спеціалістами немедичних спеціальностей. Матеріали та методи. Ми провели систематичний пошук у базі PubMed та Cochrane Library до 27 грудня 2021 року статей англійською мовою. Використовували таку стратегію пошуку: (((COVID-19) OR (SARS_COV-2)) AND ((((mental health) OR (stress)) OR (anxiety)) OR (depression))) AND ((((nurse) OR (physician)) OR (doctor)) OR (healthcare worker)). Мета-аналіз включав лише результати обсерваційних досліджень, опублікованих англійською мовою, які вивчали рівні тривожності, депресії та стресу за шкалою DASS-21 серед медичних і немедичних працівників, та не мали ризику систематичної похибки відповідно до Кокранівського положенння про написання систематичних оглядів втручання. Мета-аналіз проводили за допомогою методу фіксованих ефектів за допомогою Review Manager 5. Результати: Мета-аналіз включав 2 дослідження із загальною кількістю 912 респондентів, які відповідали необхідним критеріям. Згідно з мета-аналізом було виявлено, що в умовах пандемії COVID-19 у медичних працівників рівень стресу в порівнянні з немедичними спеціальностями підвищився майже в 1,5 рази (OR = 1,47, 95% ДІ 1,02-2,12, p =0,040). Рівень тривожності медичних працівників порівняно зі спеціалістами інших галузей і спеціальностей під час пандемії зріс у 2 рази (OR = 2,07, 95% ДІ 1,45-2,96, p<0,001). Рівень тривожності медичних працівників порівняно зі спеціалістами інших галузей і спеціальностей під час пандемії зріс у 2 рази (OR = 2,07, 95% ДІ 1,45-2,96, p<0,001). Згідно з вибраними дослідженнями, рівень депресії у медичних працівників суттєво не відрізнявся від рівня в інших галузях (OR = 1,02, 95% ДІ 0,69-1,50, p=0,920). Згідно з проведеним аналізом рівень депресії у медичних працівників суттєво не відрізнявся від рівня робітників в інших галузях (OR = 1,02, 95% ДІ 0,69-1,50, p=0,920). Висновки. Таким чином, в контексті пандемії COVID-19 медичні працівники більш схильні до стресу та тривоги, ніж ті, хто працює в інших галузях. Однак слід враховувати невелику кількість включених досліджень через значні вимоги до якості відібраних аналітичних досліджень, що може призвести до мінливості результатів. Полтавський державний медичний університет Кафедра психіатрії, наркології та медичної психології Мац О.В., Бойко Д.І. matsoksana040@gmail.com


Submm Galaxies: Signposts of Protoclusters (an on-going investigation…) Co-Is: Peter Capak (Caltech, USA), Andrew Blain (Leicester, UK), Kartik Sheth (NRAO/ NASA), Thiago S. Gonçalves (Valongo), Claudia Scarlata (U. Minnesota), A. Charbonnier (Valongo), S. C. Chapman (Dalhousie U.), I. Smail (Durham U.), R. Ivison (Edinburgh/ESO) Karín Menéndez-Delmestre Valongo Observatory (UFRJ, Rio de Janeiro) Target candidate overdensities at z~2-5 (HDF-N, ELAIS-N2, COSMOS) using LRIS/Keck, IMACS/Baade, LFC/ Palomar and GMOS/Gemini-N ① Identification of overdensity members: > 200 Ly-α emitters 411 - Bs 411 -g 16h-field Ly-α NB selection of Ly-α emitters + spec follow-up of continuum detected objects with photo-zs λ Ly-α 4.5 4.6 4.7 4.8 Redshift 0 2 4 6 8 10 Number Of Galaxies SMG SMG SMG QSO SMG Redshift COSMOS SMG at z~4.5 Redshift peaks around SMGs KMD in prep.


Exchange Exchange OPEN RESEARCH OPEN RESEARCH Sharing experiences of embedding Open Research practices at the University of Manchester 18th November 2020, 10am-12.30pm Register your place: https://bit.ly/3osxOpW @uomlibresearch #OR_Exchange


KIT – The Research University in the Helmholtz Association Motivation Extent and diversity of environmental data continuously increase due to more and new sensors with higher spatial and temporal resolution and due to the growth and automation of observational networks. These data form the basis for a better understanding of ecological systems either by data driven methods or by comparisons of data with model predictions. Still, a considerable amount of data are difficult to access or even stored on local data storage devices making it difficult or yet impossible to find, access and re-use it. In addition the data often lack a proper description (metadata) required for an interoperable analysis, hence they are barely useful for science. This results in very time consuming preparation and pre-processing of data, especially when datasets from different sources are combined. Steinbuch Centre for Computing (SCC), Institute of Water and River Basin Management (IWG) V-FOR-WaTer – a virtual research environment to access and process environmental data Marcus Strobl*, Elnaz Azmi, Sibylle K. Hassler, Mirko Mälicke, Jörg Meyer, Erwin Zehe *email address: marcus.strobl@kit.edu Objectives Quick and simple access to hydrological data and tools Quick pre-processing of data from diverse data sources Shared tools for reproducible data analysis Opportunity to easily upload data to established data repositories for publication Centralize hydrological data from universities and state offices for a coordinated long-term monitoring Security layer to ensure that users can access only data for which they have access rights Tools Geostatistics and analysis tools integrated as Web Processing Services, WPS (see scikit-gstat in Software). Based on the standalone python toolbox hydrobox (see Software) Results will come with references to enable users to cite data owners appropriately Graphical workflow tool will be integrated Data Extensive metadata model to ensure usability of stored datasets Initial data in the portal come from the KIT Hydrology group (IWG) and LUBW (Landesanstalt für Umwelt, Baden-Württemberg) Development and testing of the portal is based on datasets from the CAOS research unit (Catchments as organised systems) Extensible database for user data and interface to open data repositories Website: http://www.vforwater.de/ Stay tuned! Fig. 2: Preliminary graphs from WPS toolbox for variogram analysis (left) and flow duration curves (right). Fig. 3: Screenshots of map with clusters of data with similar sample location (left), data preview (upper right) and metadata preview (lower right). Fig. 1: Screenshots of V-FOR-WaTer web portal (upper part) and detail with the active ‘filter on map’ drawing tool. Portal Login via B2ACCESS Filter menu to select data Map tools Tools for hydrological analyses Tools and data available through web portal and interfaces for common computing environments (Matlab, Python and R) Data export (cvs, shapefile) Metadata export (XML, ISO19115) Software vforwater-portal: Portal of the virtual research environment https://github.com/VForWaTer/vforwater-portal pleasant: Django based skeleton of a web portal application with maps https://github.com/VForWaTer/pleasant hydrobox: hydroligical preprosessing and analysis toolbox https://github.com/mmaelicke/hydrobox scikit-gstat: geostatistics tools https://github.com/mmaelicke/scikit-gstat Dieses Poster steht unter der Lizenz Creative Commons Namensnennung 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/legalcode


Juliana García-Mejía, David Charbonneau, Dan Fabricant, Jonathan Irwin, Robert Fata, Joseph Zajac, Brian McLeod, Peter Doherty, Ryan Cloutier Tierras the Observatory First Light Results from a New Ultra- precise Time-series M-dwarf Photometer For more information, contact: juliana.garcia-mejia@cfa.harvard.edu State-of-the-art ground-based robotic facilities studying mid-to-late M dwarfs and their planets typically reach per-point night-to-night photometric precisions in the order of 3000 ppm. These experiments are limited by precipitable water vapor (PWV) error, since water features in the photometric bandpass result in a color dependent offset when comparing the relative brightness of the red target to the blue field stars. We have refashioned the 1.3-m 2MASS N telescope located at the F.L. Whipple Observatory atop Mount Hopkins, Arizona, into an ultra-precise time-series photometer. The Tierras Observatory is designed to (1) limit systematic errors, notably PWV error, to <250 ppm across an observing season and (2) limit stochastic errors, notably scintillation and target photon noise, to less than that of an Earth-transit for a 5 min integration time, for all stars with radii <0.3 R⊙ out to a distance of 15 pc. For more information, please refer to Garcia-Mejia et al. Proc. of the SPIE, 114457R, arXiv:2012.09744, (2020). Science Operations Have Begun! A Representative First-Light Tierras Light Curve Secondary Baffle 1 3 820 830 840 850 860 870 880 890 900 910 Wavelength (nm) 0 20 40 60 80 100 Transmission (%) Tellurics, 5mm Filter (Empirical) A four-lens focal reducer and field-flattener under the 1.3-m primary mirror (M1), which increases the field of view from a to a side and allows us to monitor more comparison stars. 0.19∘ 0.50∘ A custom narrow (40.2 nm FWHM) bandpass filter centered at 863.5 nm (right plot) avoids prominent telluric features and desensitizes our o b s e r v a t i o n s f r o m changes in PWV. 400 600 800 1000 Wavelength (nm) 0.0 0.2 0.4 0.6 0.8 Quantum E±ciency Tierras CCD MEarth CCD Summer 2021: Installed the Tierras filter, optics, and CCD dewar under M1 (top left). Fall 2021: Tested the remote control software on- s k y , c o l l i m a t e d t h e telescope, and reached first light! Winter 2021-2022: Built and installed a new set of baffles to minimize sky background (bottom right). On the left, we show a schematic diagram of the optics, along with representative ray traces and spot diagrams. Plate scale = 0.43’’/pixel. 2 A deep- d e p l e t i o n C C D operating in fast f r a m e t r a n s f e r (shutter-less) mode with>85% quantum efficiency (QE) in our bandpass (right plot), low read-noise and low dark current. A custom dewar houses the CCD, maintaining it at -105℃. 4K × 4K Commissioning Summary CCD Dewar Mount Plate Optics Installation Fixture Mount Surface Filter mounted to its bezel CCD chip with masked readout regions Primary Baffle Primary Mirror LHS 2913 - M3 star 13 pc away. This light curve (left) is not de-trended, highlighting the efficacy of our filter. We are already meeting our photometric precision goals on this star (right). Project Overview LHS 2913 The design choices enabling our photometric precision goals include:


Innovative Research for a Sustainable Future www.epa.gov/research Fidelity: 20.7% of papers with complete documentation had an accurate, fully described mathematical basis. The most commonly observed error was inconsistent units within the model equations (35.3% were erroneous, and 34.5% of the rest were ambiguous). A Method to Quantify Reproducibility in PBPK Model Methods and Results Risa R. Sayre1,2, R. Woodrow Setzer1, John Wambaugh1, Christopher M. Grulke1 1: U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology 2: Oak Ridge Associated Universities Risa Sayre l ORCiD 0000-0002-6173-8020 l sayre.risa@epa.gov l 919-541-4871 4. Conclusions & Discussion 5. References Physiologically-based pharmacokinetic (PBPK) modeling describes how the amount of an exogenous chemical in the body changes over time, using values specific to properties of that chemical in a system of equations representing relevant biological processes. (1) National Research Council, Committee on Toxicity Testing and Assessment of Environmental Agents, Board of Environmental Studies and Toxicology, Institute for Laboratory Animal Research, Toxicity Testing in the 21st Century. A Vision and a Strategy , 2007a Washington, DC National Academies Press (2) U.S. Environmental Protection Agency (EPA). (2006) Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment. National Center for Environmental Assessment, Washington, DC; EPA/600/R-05/043F. (3) McLanahan, E. D., El-Masri, H. A., Sweeney, L. M., Kopylev, L. Y., Clewell, H. J., Wambaugh, J. F., Schlosser, P. M. (2012). Physiologically Based Pharmacokinetic Model Use in Risk Assessment - Why Being Published Is Not Enough, Toxicological Sciences, 126(1), 5-15. (4) Barton, H. A., Chiu, W. A., Setzer, R. W., Andersen, M. E., Bailer, A. J., Bois, F. Y., DeWoskin, R. S., Hays, S., Johanson, G., Jones, N., Loizou, G., MacPhail, R. C., Portier, C. J., Spendiff, M. Tan, Y. (2007) Characterizing Uncertainty and Variability in Physiologically Based Pharmacokinetic Models: State of the Science and Needs for Research and Implementation, Toxicological Sciences, 99 (2), 395-402. (5) International Programme on Chemical Safety. Characterization and application of physiologically based pharmacokinetic models in risk assessment. (IPCS harmonization project document; no. 9). WHO 2010. (6) Clark, L. H., Setzer, R. W., & Barton, H. A. (2004). Framework for evaluation of physiologically- based pharmacokinetic models for use in safety or risk assessment. Risk Analysis, 24(6), 1697–1717. (7) Pearce, R., Setzer, R., Strope, C., Sipes, N., & Wambaugh, J. (2017). httk: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software, 79(4), 1-26. (8) MacLeod, M., Scheringer, M., McKone, T. E., & Hungerbuhler, K. (2010). The State of Multimedia Mass-Balance Modeling in Environmental Science and Decision-Making. Environmental Science & Technology 44 (22), 8360-8364 | Figures implemented in Python 3.5 using matplotlib_venn | Analysis conducted using Python 3.5, R 3.3.2, MATLAB R2015a Fig 1. Basic inhalation PBPK model system, showing model compartments and flows (figure from IPSC5) toxicity testing dose-response (PBPK) modeling human exposure data risk contexts Models describe a system by synthesizing knowledge and assumptions into a quantitative expression, so context matters8. While building an open PBPK model database for risk assessors and modelers from 973 publications, we wanted to effectively capture complete parameterization for all models. We developed a list of criteria to systematically quantify common, fundamental obstacles to reproduction of methods and results for this set. Fig 2. Equation example (figure from McLanahan et al.3). A concentration flows into a compartment at a rate determined by blood flow. The concentration flowing out is reduced by the amount that partitions into the tiss


To: Ms. Louise Chamberlain Resident Representative UNDP Kyrgyzstan To: Ms. Louise Chamberlain, Resident Representative UNDP Kyrgyzstan From: Ms. Aizhan Ussenaliyeva International Scientist and Researcher ( ORCID #0000-0002-7084-8352 ) Founder and CEO of Save Lake Balkhash International Research Project Dear Ms. Louise Chamberlain, I am an international female scientist and researcher, currently leading a scientific research dedicated to clean water preservation and multi-sectoral knowledge creation, transfer and exchange between heavy industrial technologies and climate change innovative solutions. As a founder and CEO of the first water data open research I represent millions of women across the globe who strive to find reasonable solutions to the most critical social threats, such as lack of access to clean water and sanitation, poverty, gender discrimination and climate change. There are 7 Global Sustainability Development Goals that my project corresponds to: SDG5 – Achieve gender equality and empower all women and girls, SDG6 - Clean water and sanitation SDG 11 - Sustainable cities and communities, SDG 12 - Responsible consumption and production, SDG 13 - Climate Action, SDG 14 - Life below water and SDG15 - Life on land. The DNA of my research is based on holistic relationships between nature and people and is programmed to create an ecological data to facilitate communication between academia, corporate world, governmental entities and public sector. My work was published in Science Magazine and recently I got invited to join the 6th International Conference on Environmental Sustainability and Climate Change as a speaker in Philadelphia, USA in August 21-22, 2023. I create an intersection between lakes reproductive cycle and energy security and my work benefits socio-economic development of Central Asian region. I created a free access open data library to share my knowledge for the benefit of global community and educated 50,000 people from 18 countries: https://figshare.com/authors/Aizhan_Ussenaliyeva/12049805 https://orcid.org/0000-0002-7084-8352 I am asking to support my independent scientific research by sponsoring my trip to the above mentioned international climate change conference and a website launch to educate more people across the globe. This will help to promote female-led scientific projects and climate change initiatives in Kyrgyzstan, where I reside and continuously work on my research. Sincerely, Ms.Aizhan Ussenaliyeva 03.06.2023 Save Lake Balkhash International Research Project Osmonkula 128, Office #4 Bishkek, Kyrgyzstan Tel.: +996508558511 Email: savelakebalkhash@gmail.com


Affilliations: 1University of Exeter; 2Durham University References: [1]: Goluskin, D. et al., ‘Convectively Driven Shear and Decreased Heat Flux’. Journal of Fluid Mechanics 759 (1 November 2014): 360–85 [2]: Burns, K. J. et al., , "Dedalus: A Flexible Framework for Numerical Simulations with Spectral Methods," Physical Review Research 2 (23 April 2020): 023068 [3]: Orvedahl, R. et al., ‘Prandtl-number Effects in High-Rayleigh-number Spherical Convection’. ApJ 856 (20 March 2018): 13 [4]: Currie, L. et al., ‘Convection with misaligned gravity and rotation: simulations and rotating mixing length theory’. MNRAS 493 (10 February 2020): 5233-5256 [5]: Brown, B. P. et al., ‘Rapidly Rotating Suns and Active Nests of Convection’. ApJ 689 (20 December 2008): 1354-1372 Implications Sun Ra ≈ 1020 Pr ≈ 10-7 [3] - Astrophysical values for Ra and Pr are inaccessible to direct numerical simulations - Mixing Length theory is widely employed in astrophysics to model convection (e.g. [4]) but assumes a particular 𝑁𝑢(Ra) relationship and does not take shear into account - If realised in a star, shear would likely effect the entropy gradient and other aspects of interior convection So, can stars shear? 3D isotropic convection does not appear to establish shearing states. However… - Rotation and magnetism can make convection more anisotropic, forcing quasi-2D behaviour in nature (e.g. [5]) - These cases may allow for ‘bursts’ of shear damping vertical transport as described here. We intend to investigate the 3D, rapidly rotating equivalents of these states in future work Fig 2: Temperature snapshots from numerical simulations showing “normal” convection (left) and ”shearing” (right) Fig 1: A schematic comparing “normal” convection and “shearing” convection All stars transport heat by convection and the efficiency of this transport is affected by (among other things) shear flows 2-D Rayleigh-Bénard convection has been observed to drive horizontal ‘shearing’ flows These flows are characterised by very little vertical convective energy transport These flows can be reproduced in numerical simulations, and have been explored for Prandtl number greater than unity [1] We present numerical simulations of Rayleigh-Bénard convection for Prandtl numbers less than 1, to better approximate the astrophysical environment What is Shearing Convection? Fig 3: Comparisons of diagnostic quantities for Pr=0.1 (left) and Pr=0.01 (right). A triangle represents a shearing case, and a circle is a non-shearing case Results Shearing states are readily established in low Pr convection The Pr=0.1 cases make it clear that shearing cases are described by a different 𝑁𝑢Ra relationship that non-shearing cases The vertical heat transport is radically altered by the presence of strong shear The Dedalus pseudo-spectral code [2] was used with periodic boundary conditions to simulate a range of parameters (left) for one viscous time Table 1: The simulated parameters. A tick represents cases with shearing flows. The shaded boxes were not simulated Rayleigh number (Ra) is a measure of flow buoyancy – higher means more convective driving Prandtl number (Pr) is the ratio of viscosity to thermal diffusivity Nusselt number (𝑁𝑢) is the time-averaged ratio of convective to conductive flux at a boundary - 𝑁𝑢=1 corresponds to pure conduction; the larger the value of 𝑁𝑢the more vigorous the convection Dimensionless Definitions Our Simulations Fig 3: Instantaneous Nusselt Number 𝑁𝑢(𝑡) for a non-shearing (left) and a shearing (right) case An Investigation Into Convectively Driven Shear At Low Prandtl Number Tom Joshi-Cale1 Matthew Browning1 | Simon Lance1 | Laura Currie 1,2 tj294@Exeter.ac.uk TomJoshiCale Pr \ Ra 1e4 5e4 1e5 3e5 5e5 1e6 0.1 0.01


Christian Gutsche on behalf of the ATLAS Liquid Argon Calorimeter group Institute of Nuclear and Particle Physics, TU Dresden, Germany Machine Learning for Real-Time Processing of ATLAS Liquid Argon Calorimeter Signals with FPGAs DIS2022: XXIX International Workshop on Deep-Inelastic Scattering and Related Subjects • Sampling calorimeters for the measurement of energy deposited by electrons, photons and hadronic jets • 182 000 cells filled with Liquid Argon as medium for ionization • Resulting triangular pulse is amplified, shaped and digitized at 40 MHz • Energy reconstruction with Optimal Filter (OF): linear combination of up to 5 samples 2. Phase II Readout Electronics Upgrade ●High Luminosity LHC (HL-LHC) planned to start in 2029 with up to 7.5 times nominal luminosity ●About 140 proton-proton-collisions per bunch crossing ●Challenges for LAr calorimeter readout under HL-LHC conditions: ●Revised trigger scheme allows selection of events at 1 MHz and in subsequent bunch crossings (BC) ●Number of events with overlapping signals will increase → in-time and out-of-time pile-up ●New Liquid Argon Signal Processor (LASP) boards will be installed during Long Shutdown 3 (LS3, Phase-II upgrade): ●FPGA to implement more complex real-time energy reconstruction algorithms ●Maximum latency of ~150 ns required by trigger ●Up to 512 detector cells processed on one FPGA ●Readout chain can be simulated with AREUS software: ●Supports electronics noise, digitization and LHC bunch train structure ●Generates digitized pulse sequence as expected from specific detector cell 3.1 Convolutional Neural Networks (CNN) ●Machine Learning solutions under investigation to replace OF in future HL-LHC conditions ●Pulse tagging sub-network (2 layers) ●Sigmoid activation function ●Energy reconstruction sub-network (1-2 layers) ●Uses results of tagging sub-network and raw ADC samples ●ReLU activation function ●Trained and evaluated on AREUS samples ●Training in two stages: 1. Tagging part only as pre-training 2. All layers together for energy reconstruction 0 5 10 15 20 25 30 35 40 BC 1 − 0 1 2 3 4 5 [GeV] T E True energy Digitized signal AREUSSimulation ) = (0.5125, 0.0125) φ , η EMB Middle ( > = 140 µ < 0 1 2 3 4 5 [GeV] T E BC #6 BC #7 BC #8 BC #9 BC #10 RNN ADC(6) RNN ADC(7) ... RNN ADC(10) 0 Dense ET(7) 0 1 2 3 4 5 [GeV] T E BC #7 BC #8 BC #9 BC #10 BC #11 RNN ADC(7) RNN ADC(8) ... RNN ADC(11) 0 Dense ET(8) 0 1 2 3 4 5 [GeV] T E BC #8 BC #9 BC #10 BC #11 BC #12 RNN ADC(8) RNN ADC(9) ... RNN ADC(12) 0 Dense ET (9) 3.2 Recurrent Neural Networks (RNN) RNN cell ADC(n) Dense ET (n − 4) RNN cell ADC(n + 1) Dense ET (n − 3) RNN cell ADC(n + 4) Dense ET (n) RNN cell ADC(n + 5) Dense ET (n + 1) ... ... ... ●RNNs have connections between nodes over time → memory ●Long Short-Term Memory (LSTM) well suited for long sequences due to gated design ●Limited number of internal dimensions and only one layer due to FPGA resource constraints ●Single dense neuron as decoder to reconstruct energy from LSTM output ●Single-cell LSTM (above) ●Operates sample per sample on entire sequence ●Expected to be more robust for overlapping pulses ●Sliding-window LSTM (right) ●Newly instantiated LSTM operates on fixed number of past samples at each BC ●Expected to be more robust for isolated pulses ●Vanilla RNN: simple structure to reconstruct energy and forward information 3.3 Performance in Simulation ●CNNs and RNNs outperform OF in both mean and bias behaviour ●CNNs/RNNs show less biased behaviour with overlapping pulses Figures: difference between predicted and true energy over the temporal gap between two higher energy deposits for OF (right) and and different types of artificial neural networks (ANN) (bottom) 4. FPGA Implementation and Performance ●CNN: Direct implementation in VHDL ●Optimal use of DSP resources on FPGA ●Architecture automatically configured from files obtained during training ●RNN: High Level Synthesis approach ●Easier design and more flexibility in architecture ●Go


IT IS NOT THAT FUNNY. CRITICAL ANALYSIS OF RACIAL IDEOLOGIES EMBEDDED IN RACIALIZED HUMOUR DISCOURSES ON FACEBOOK IN BRAZIL ABSTRACT ANATOMY OF RACISM ON FACEBOOK PRELIMINARY FINDINGS IN SUMMARY This study explores the use of Facebook as a powerful mechanism enabling individuals to disseminate and reinforce racialized discourses and negative representations of black individuals in Brazil, particularly concealed in disparagement humour posts and their associated comments. For this purpose, the study applies Critical Discourse Analysis as research method to unveil the embedded racialized and discriminatory discourses. There are five important dimensions to understand the full reach of the ideological racist discourses embedded on Facebook: 1) the target of the online racism; 2) the names of the Facebook communities where those content circulate; 3) the reverberation capacity of the posts published; 4) the actual comments; and 5) the profile of the individuals who engage in this behaviour and their inner motivations for doing so. Preliminary fieldwork results have revealed the following aspects: a) almost 80% of the victims of online mockery are predominantly middle-class, well-educated black women aged between 20 to 38 years; b) oftentimes the derogatory posts employ rude and impolite language to talk about black individuals; c) many users of Facebook communities displaying derogatory content express their endorsement to the content with laugher and jeer; d) there are evidence indicating a considerable degree of reverberation capacity of the derogatory comments given that they can potentially engage users for months and even for a couple of years after the original publication; and e) black women are at the forefront of the initiatives to challenge those derogating practices. It can be inferred that the underlying discourse embedded in the posts displayed on Facebook convey that being black in Brazil is associated with engagement to low qualified jobs, that is expected that they do not hold an university degree or any schooling at all, they are prone to be involved with illegal activities, they predominantly live in favelas and that their social place is at the lower social strata and there is the place where they should stay. On top of that, it is also considered that Facebook as a social media platform, enables individuals to convey their racist and discriminatory ideologies in such a way that it was not possible before, and due to social convention constraints, the sort of derogatory comments displayed online is not usually expressed in ordinary face-to-face interactions. Finally, the reverberation of the posts strongly contributes to the reinforcement of the disparagement discourse given that they keep engaging people for a long period of time in this conversation like an echo in cyberspace. Image: Shutterstock 2017 Luiz Valério de Paula Trindade | PhD candidate in Sociology Supervisors: Dr Bindi Shah | Dr Laura Lewis | Dr Charlie Walker


Simultaneous NuSTAR – XMM-Newton observations of AGN Abstract Joint X-ray observations of the satellites XMM-Newton and NuSTAR have become the main tool to study the 6.4 keV iron K alpha line emission in the direct environment of black holes. The soft (XMM-Newton) and hard (NuSTAR) X-ray spectra together allow determining the continuum, absorption, reflection and emission lines. In order to get better results in future, the present study aims to help improving the cross-calibration by analyzing all publicly available simultaneous NuSTAR – XMM-Newton observations in a coherent way. Andrea Gokus1,2, Norbert Schartel2, Maria Santos-Lleo2, Jörn Wilms1, Thomas Dauser1, Felix Fürst3, Ralf Ballhausen1 XMM-Newton Artist's impression of XMM-Newton ©ESA Launched in 1999, ESA's XMM-Newton observes the energy range from 0.2 to 12 keV with the European Photon Imaging Camera (EPIC) using a Wolter type I telescope. Additionally it has an Optical Monitor (OM) and a Reflection Grating Spectrometer (RGS) onboard. NuSTAR NuSTAR, launched by NASA in 2012, is the first focusing high-energy instrument in space. It uses Wolter type I approximation optics and two semiconductor detectors (FPMA, FPMB) to observe hard X-rays from 3 to 79 keV. The 10 m long mast was deployed in space. Artist's impression of NuSTAR ©NASA 1Dr. Karl Remeis Observatory & Erlangen Centre for Astroparticle Physics (ECAP), Universität Erlangen-Nürnberg, Sternwartstraße 7, 96049 Bamberg, Germany 2European Space Astronomy Center (ESAC), ESA, 28692 Villanueva de la Cañada, Madrid, Spain 3Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125, USA Why simultaneous observations? Performing observations with XMM- Newton and NuSTAR together has the main advantage that they have an energy overlap between 3 and 12 keV, which includes the region of the iron K alpha line. The emission features around 6.4 keV allow the analysis of relativistic line broadening near black hole systems, when the underlying continuum is well known. This can be achieved with a simultaneous obser- vation by both satellites, since their effective areas overlap from 3 to 12 keV. Comparison of the effective area of the XMM-Newton satellite (black) and the NuSTAR satellite (red). Comparison of XMM-Newton and NuSTAR data Ideally, with a perfect calibration, a model for a certain X-ray spectrum should give the same results when applied to both XMM-Newton and NuSTAR data. Since the perfect calibration is not possible to achieve, calibration uncertainties make discrepancies appear in the data analysis and the determination of astrophysical values is impacted. Those discrepancies can be shown, e.g. by fitting a model to an XMM- Newton spectrum and then comparing the strictly simultaneous NuSTAR spectrum with this model (see ratio plots below; black: XMM-Newton EPIC PN data, red: NuSTAR FPMA data, green: NuSTAR FPMB data; the data has been binned for clarity). The used models contain a powerlaw and the X-ray absorption model tbnew (Wilms et al., 2000; http://pulsar.sternwarte.uni-erlangen.de/wilms/research/tbabs/). If the source shows relativistic reflections effects, the reflection model relxill (Dauser & Garcia et al., 2014) is included as well. Ark 120 Seyfert 1 galaxy z = 0.0327 3C 273 Blazar z = 0.158 MCG-6-30-15 Seyfert 1 galaxy z = 0.008 Swift J2127.4+5654 Narrow-Line Seyfert 1 Galaxy z = 0.0144 3C 120 Broad-Line Radio Galaxy z = 0.0336 ΔΓ EPN-FPMA 0.135 ± 0.004 EPN-FPMB 0.128 ± 0.007 Results & Conclusions A difference between the photon indices for data from both satellites can be found when fitting the spectra from 3 to 10 keV simultaneously. This has been done with a sub-sample of 12 observations of 6 AGN. The difference can be plotted over the flux of the different sources in order to show that ΔΓ is independent of the flux and therefore not due to pile-up. The mean differences for EPN-FPMA and EPN-FPMB are: These preliminary results show a potential cross-calibrati


Forschungsdaten am Max-Planck-Institut für Evolutionsbiologie Carsten Fortmann–Grote, Beate Gericke, Iben Martinsen, Kristian Ullrich, Derk Wachsmuth Digitale Woche Kiel, 15. Mai 2024 Grundsätze Daten Management Plan zu Beginn eines Projekts Alle Rohdaten sind in internen Datenbanken hinterlegt und dokumentiert (OpenBIS, OMERO, GitLab) Rohdaten und Quellcode for publizierte Resultate in offenen Repositorien hinterlegt Datenquellen (C) Zeiss Bilddaten Mikroscopie CT, Röntgen Kameras (C) Illumina Sequenzdaten Intern Extern (C) IBM Simulationen Onsite Offsite Schema Data collection Data analysis DMP Sequence data Materials Notes Protocols Simulation data Image data Code OMERO Storage openBIS GitLab/Hub DMP FDK DMP Library FDK edmond zenodo ENA BIA GitLab/Hub PuRe Results Publication Library Reuse Checklist DMP=Daten Management Plan FDK=Forschungsdatenkoordinator Repositorien Doku Intern Öffentlich Sequenzen OpenBISSeq. ArchivSRA, ENA MikroskopieOMERO OMERO BioimageArchive Code GitLab GitLab Github, Edmond Elektronisches Laborbuch und Labor-Informations-Management System OpenBIS ETH Zürich Laborbuch Bakterienstämme Formblatt Z Sequenzieraufträge Mikroskopie Datenbank OMERO Daten per GUI importieren Key-Value Annotationen Webform Spreadsheet Kontrollierten Vokabularien Copyright: Max-Planck-Gesellschaft (2024)


ARMA Research Office Survey 2020 | Benchmarking UK Institutional Research Offices Report and infographics prepared for ARMA by Research Consulting Limited. University of Nottingham Innovation Park, NG7 2TU, UK | www.research-consulting.com Research Consulting Limited is a Company Registered in England and Wales Reg No. 8376797 This work is licensed under a Creative Commons Attribution 4.0 International License. Most likely to be in the research office remit Distribution of research office staff by functional areas Support for REF Research Policy & Strategy Research governance, ethics and integrity Pre-award & costing Research systems and MI Least likely to be consistently in the research office remit Scholarly comms, outputs and bibliometrics Public engagement Post-award management Doctoral Schools and PGR support Research finance A major survey of directors of UK research offices: structures, staffing and trends One third of UK universities responded to the survey through Directors of Research. Responses considered 19 functional areas that can fall within the research office remit and job functions, covering over 2,000 reported FTEs. ARMA Research Office Survey 2020 74% report absorbing activities into the existing team / roles 30% report hiring temporary staff 22% report that staff in other areas are seconded to REF-related roles Remit and functional areas How do research offices handle additional resourcing needs associated with the REF preparation and submission process? Managing the Research Excellence Framework Functional areas Other Research Policy & Strategy Systems and MI Support for REF Research impact Governance, ethics & integrity Executive & admin support Research finance Post-award Pre-award & costing Business development Doctoral School/PGRs & researcher dev Research contracts % of FTEs from 2,011 total 4 % 4 % 4 % 5 % 5 % 6 % 7 % 7 % 9 % 9 % 9 % 1 5 % 1 6 %


MD pharmacophore-based search for novel MARK4 inhibitors: in silico and in vitro studies Alina Kutlushina, Olena Mokshyna, Lenka Hruba, Sona Gurska, Marian Hajduch, Petr Dzubak, Pavel Polishchuk Institute of Molecular and Translational Medicine, Palacký University and University Hospital in Olomouc, Olomouc, Czech Republic alina.kutlushina@upol.cz This work was supported by the INTER-EXCELLENCE LTARF18013 project (MEYS), the European Regional Development Fund - Project ENOCH (No. CZ.02.1.01/0.0/0.0/16_019/0000868) and ELIXIR CZ research infrastructure project (MEYS Grant No: LM2018131). MD snapshot timeline MD pharmacophores 3D pharmacophore hashes MD representative pharmacophores Materials and Methods Hit1 MARK1 MARK2 MARK3 MARK4 IC50, μM >50 14.72 0.0088 0.032 Hit2 MARK1 MARK2 MARK3 MARK4 IC50, μM >50 19.79 >50 12.01 Results Summary We developed and validated a workflow for virtual screening based on our previous implementation of MD pharmacophores and molecular docking. We were able to find a novel MARK inhibitor which was selective over 1 and 2 subtypes of MARK family and can be promising for further research. github.com/ci-lab-cz/pharmd A B D F G 1 2 3 4 5 compound conformers 4 5 = 0.8 CCA score RTB <= 5 MW <= 500 Da MD snapshot timeline 150 ns 5965 5221 4015 2532 MD representative pharmacophores 3938 2331 4989 5876 5+ features MD representative pharmacophores MD pharmacophore virtual screening 68337 molecules 3.8 % up to 50 conformers Conformers coverage Approach (CCA) 618 molecules 0.035 % Molecular Docking 235 molecules 0.013 % Visual inspection of the docked poses 24 hits 1783794 molecules 100 % The complexes of MARK4 with the 4 initial inhibitors MARK1, μM MARk2, μM MARK3, μM MARK4, μM >50 >50 >50 0.95 >50 >50 38.8 0.59 >50 >50 >50 0.47 >50 >50 >50 1.29 CCA score is the number of conformers which were mapped by at least one pharmacophore from the representative set divided by the total number of conformers. A B C D E F G b36..87 53b..ef 53b..ef e4f..ce 53b..ef 4af..f3 79f..31 MARK4 protein is a Serine/Threonine protein kinase, structurally related too the AMPK/Snf1 subfamily of the CaMK group of kinases. MARK4 proteins’ abnormal function has been associated with several pathological conditions including Alzheimer’s disease, which makes it a promising target for drug development. In the current study we searched for selective MARK4 inhibitors of new chemotypes too extend structural diversity of compounds for further selection and optimization . For this purpose, we used the workflow based on molecular dynamics (MD) pharmacophores. This approach allows us too take intoo account the conformational flexibility of the protein, while a pharmacophore is an abstract representation of the molecular interactions of the ligand with the protein, which is not related too the specific compound structure. Introduction 5RC MARK1 MARK2 MARK3 MARK4 IC50, μM 0.0041 0.0025 0.0039 0.0046 The MARK4 crystal structure exists in complex with a pyrazolopyrimidine (PDB ID: 5es1). The inhibitor (5RC) is highly active too MARK4 but not specific. Correlation of CCA and docking scores Distribution of the docking scores up to 50 conformers ChEMBL + proprietary 90 inactive and 29 active Virtual screening on validation set Quality assessment of MD representative pharmacophores PharMD MD pharmacophore virtual screening 68337 molecules 3.8 % up to 50 conformers Conformers coverage Approach (CCA) 618 molecules 0.035 % Molecular Docking 235 molecules 0.013 % Visual inspection of the docked poses 24 hits 1783794 molecules 100 % AutoDock Vina ChEMBL Proprietary Found hit Database Molecular space visualization of known MARK4 inhibitors (t-SNE) Tanimotoo 0.202 The nearest structure 0.205 White structures are poses determined by pharmacophores Pink structures are docked poses by AutoDock Vina -8.6 -8.1 -7.6 -8.8 -9.4 Docking score Proprietary reference compounds 0.03 The most distantMol 2Mol 3


#SuperPV @SUPERPV_H2020 Intermediate SUPER PV project results have been already achieved in WP3, which is focusingon the development and demonstrationof the following PV module innovations: • low cost and easyto apply multifunctional nano-coatingswith antisoiling and antireflectiveproperties in one layer. • light managementin bifacialc-Si modules to increasethe power output up to 7 Wp. • laminateddiode innovations produced by solarcell production • low-cost encapsulation innovation with a low-cost humidity barrierleading to 45% cost reduction of flexible CIGSmodules • inline inspection system of encapsulation process for CIGS modules • recyclingapproaches and their demonstration to alltypes of modules under consideration in SuperPV project • Cost and performanceevaluation (Eur/Wp, Eur/kWh). Julius Denafas, „Soli Tek R&D“ UAB SUPER PV PROJECT – SUPPORT COST-REDUCTION OF THE PV SYSTEM THROUGH INNOVATIVE TECHNOLOGIES ON PV MODULE LEVEL This project has received findings from the European Union’s Horizon 2020 research and innovation programme under grant agreement N° 792245. The sole responsibility for the content of this material lies with the authors. It does not necessarily reflect the opinion of the European Union. Neither INEA nor the European Commission are responsible for any use that may be made of the information contained therein. www.superpv.eu Find us on Contact details of Project Coordinators Mr. Juras Ulbikas (juras.ulbikas@protechnology.lt) & Mr. Julius Denafas (Julius.Denafas@solitek.eu) PV module innovations introducing and combining five PV module innovations applied to c-Si based bifacial modules and CIGS modules. MULTIFUNCTIONAL COATINGS LIGHT HARVESTING Laminated By-Pass Diodes COST EFFECTIVE BARRIER LAYER FOR FLEXIBLE THIN FILM SOLAR MODULES PV module innovation transfer and costs: intermediate assessment PET sheet barrier coating front eletrode absorber back electrode PI substrate encapsulant back sheet encapsulant Modules laminated with a PET foil with nanometric Al2O3 or SiNx barrier had a similar output at 1000 hour of 85oC/85 % RH damp heat exposure as with a reference (high grade) front sheet. CIGS module on poly-imide substrate, laminated on back sheet, bonded to PET foil with Al2O3 coating. Problem description: The encapsulation costs are the main drawback for current flexible light weight applications of thin film modules. This innovation will open new market segments for building integrated PV where typical PV system cannot be applied because of their high additional weight. Time between layers Transmittance (visible light) Water Effect (Contact angle) Anti – Soiling Non Treated --- 89 --- --- AR + AS HFB 0 minutes 89 HFB 105.03º AS: √√ EtC: ≈ AR + AS HFB 5 minutes 90 HFB 121.57º AS: √≈ EtC: √√ AR + AS HFB 30 minutes 90 HFB 121.80º AS: √≈ EtC: √√ Good AR PropertiesPropertiesAnti Anti ––Powder PowderEffect EffectHFB Performance HFB Performance Estimated gain due to antireflectivity was: 1,4% for single coating 2,8% for double coating Produced and in-house coated six 60-cell modules Gain for AR + HFB easy coatings was 1.8-2.0% Gain for AR + HFL easy coatings was 0.6-1.0%Laboratory Laboratoryresults resultsof ofreal PV modules real PV modules Solar panel Bifacial solar cell White colored rear glass No power reduction due to in-laminate bypass diodes in full size PV module IV characteristics of 60-cell monofacial modules: with and without soldered Si bypass diodes Configuration Isc [A] Imp [A] Voc [V] Vmp [V] Pmp [W] with diodes 8.75 8.36 38.66 31.84 266.24 without diodes 8.74 8.38 38.62 31.81 266.42 One module: 570g silicon shards de-metalized silicon AgCl from Ag-mesylate silver from AgCl MSA/H2O2 Assessment of PV recycling for module level innovations Pyrolysis: Rapid (~5 min) thermal heat treatment (~ 500- 600 °C) – intensive gas formation, flame – burning of gas, burning of EVA Recovery of silver: Treatment of the silicon shardes from Apollon N.I.C.E. solar modules Concept • Majority of Light


Heavily present in Arab-Islamic culture, al-Andalus, Iberia under Muslim rule, inspired one of the most popular “Islamic” televisual products in the Arab world: Al- Thulathiyya al-Andalusiyya (The Andalusi Trilogy), a set of three Arabic-language historical drama television series covering relatively intermittently the geopolitical and social evolution of al-Andalus over a period that starts around 737 and ends in 1095. To deconstruct the different dramatico-historical narratives generated by the Thulathiyya, an in-depth qualitative analysis of its three seasons is conducted that explores both the social and political norms and the historical sources its scripts draw on. The trilogy’s representation of al- Andalus is assessed, in the same analysis, in its potential function of commentary on the modern sociopolitical reality of the MENA region. HISTORY OF AL-ANDALUS AL-ANDALUS IN ARABIC TV AND FILM 1- ʿAbd al-Rahmān I, the first Umayyad prince of al- Andalus (731–788). 2- Al-Ḥājib al-Manṣūr, an extraordinary ruler of al- Andalus (938–1002). 3- Al-Muʿtamid b. ʿAbbād, the last ʿAbbādid ruler of the taifa of Seville (1040–1095). - The evolution of audiovisual representation of al-Andalus in Arabic culture. - Projections of present realities onto a romanticized space-time of Islamic history. 1970S—2022 1- Historical (of the Medieval Arabic sources upon which the scripts are based); 2- Sociopolitical; 3- Computational (of the novelized scripts, using text analytics). A TRIPLE ANALYSIS ESR 15: Mounir Saifi Al-Andalus Fictionalized Audiovisually in the Arab World (Re-)Viewing Al-Thulathiyya al-Andalusiyya from a Sociopolitical Perspective AL-THULATHIYYA AL-ANDALUSIYYA 8TH CENTURY—11TH CENTURY ITN - N°813547 Secondment 2 Nov–Dec 2021 Casa Árabe Córdoba Intensive courses on: Al-Andalus; Cultural tourism Secondment 1 Aug 2020 CNMS, Philipps-Universität Marburg In-Depth Analysis of Data Collected From Social Media Platforms Nov 2020 CNMS, Philipps-Universität Marburg Social Media Scraping and Digital Data Analytics


Relativistic meson-exchange currents in lepton-nucleus scattering V. Belocchi Universit`a degli Studi di Torino & INFN, Torino valerio.belocchi@unito.it Formalism When a lepton interacts with a nucleus two -or more- nucleons in the same interaction can be ejected, yielding to a np −nh process. This is a pure nuclear effect. Specifically, we focus on the 2p2h, based on RFG. The nuclear tensor contains matrix elements: wµν ∝⟨F| ˆJ2b† µ |2p2h⟩⟨2p2h| ˆJ2b ν |F⟩ with |F⟩the Fermi sphere and |2p2h⟩the 2p2h state. ˆJ2b µ is a two-body current, that is obtained following the Meson Exchange Currents (MEC) formalism. Subedi et al., Science 320, 1476 (2008) Meson Exchange Currents MEC for the EM-EW interaction, related to ∆resonance -a,b,c,d-, ’contact’ -e,f-, ’pion-in-flight’ -g- and ’pion-pole’ -h,i- currents. J2b µ is a fully relativistic two-body current, corresponding to the coupling of the virtual boson to a pair of nucleons exchanging a pion. It is derived from the Non-Linear σ-model Lagrangian in- vestigated in [1], where the ∆resonance is incorporated ad hoc. On the right exempla of direct and exchange many-body dia- grams, included in our computations, obtained combining two MEC currents. Inclusive process In an inclusive lepton-nucleus scattering only the outgoing lepton is detected: the 2p2h cross section is obtained including every possible hadronic final state with two ejected nucleons. Lepton-nucleus inclusive cross-section: d2σ dEe′dΩe′ = σ0 Lµν ν0 W µν A WA, L nuclear and leptonic tensor We described the 2p2h hadronic tensor in a RFG framework, hence: W µν (2p2h) = 1 4 V (2π)9 X s1,s2,s′ 1,s′ 2 t1,t2,t′ 1,t′ 2 Z hi<kF pi>kF dh1 dh2 dp1 dp2 δ4(p1 + p2 −h1 −h2 −˜q) wµν ˜q := (˜ω, q), ˜ω := ω −E2p2h s , for 12C ⇒E2p2h s = 40 MeV, kF = 228 MeV Integration over holes and particles momenta ⇒less non-vanishing hadronic contributions Results We tested our model with previous inclusive calculations for the electron [2] and for the CC neutrino [3] scattering. Double differential cross section for e 12C and νµ 12C, with quasi-elastic contribution evaluated using RFG nuclear model and the 2p2h, computed using MEC. Electron data are also shown, from archive 10.48550/arXiv.nucl −ex/0603032. Inclusive EW differential cross section as a function of the scattering angle and the energy transfer ω. Incident neutrino energy Eνµ = 550 MeV, corresponding to T2K ND flux peak. Semi-inclusive process J.M. Franco-Pati˜no, PhD Thesis (2024) In a semi-inclusive lepton-nucleus scattering an outgoing nu- cleon is detected in addition to the final lepton.We computed theoretical predictions for detected nucleon p1 lying on the scattering plane, ϕp1 = 0. Lepton-nucleus semi-inclusive cross-section: d6σ dωdΩe′dEmdΩp1 = p1Ep1 (2π)3σ0 Lµν ν0 W µν A(N) W µν A(N) := d W µν A dp1 Em = ω −Ep1 + mN Integration over holes and one particle only momenta ⇒numerous non-vanishing hadronic contributions Results Semi-inclusive predictions, with incident lepton energy E=478 MeV, energy transfer ω=263 MeV, momentum transfer q=303 MeV/c and proton scattering angle θp. Left: electron-carbon scattering, in violet the pion production threshold, data from [4]; right: CC muonic neutrino-carbon scattering, similar predictions can be found in J. Niewczas, PhD Thesis (2023). The isospin separation for ejected nucleons in final state is performed. Conclusion We computed the 2p2h contribution for the inclusive and semi-inclusive lepton-carbon scat- tering, showing preliminary weak predictions. In particular, we tested the EM-MEC formalism comparing with available semi-inclusive data focused in the ’dip’ region. For details, see [5]. Currently the 2p2h component of the cross section is simulated in event generators on the basis of inclusive calculations, necessarily relying on strong approximations. The model aims to provide a reliable description of neutrino-nucleus semi-inclusive 2p2h process, for which a complete microscopic and fully relativistic computation is still absent in t


Inter textor Interfaces für die Annotation intertextueller Relationen Ein Projekt des Service Center for Digital Humanities Münster (SCDH) Jan Horstmann Christian Lück Immanuel Normann Jan-Erik Stange Dennis Voltz Benjamin Weber Mirko Westermeier Der Intertextor ist ein in Entstehung begriffenes Werkzeug zur manuellen Erfassung und Erforschung von Intertextualität als Netzwerk. Als Vorarbeit wurde ein gemeinsamer Kern von Intertextualitätstheorien heraus- gearbeitet und formalisiert, was zu einer modularen Ontologie (RDFS und OWL) geführt hat. Sie wurde auf der DHd 2023 zur Diskussion gestellt. Hier nun zeigen wir, wie auf dieser Grundlage fortschreitend Aspekte der Visualisierung und User-Experience bei der Toolentwicklung berücksichtigt werden. Texte können in verschiedenen Zoomstufen visualisiert werden, die in folgenden UI-Elementen zum Ausdruck kommen: lesbarer Text; verkleinerter Text als Struktur von Absätzen, Überschriften usw.; Balken als lineare Textrepräsentation; Knoten in einem Netzwerk. Diese UI-Elemente können auf verschiedene Weise miteinander kombiniert werden, was zu vier verschiedenen UI-Konfigurationen führt. Sie entsprechen verschiedenen wissenschaftlichen Zugängen zu Intertextualität. Wir laden euch ein, euch bei der Anforderungsanalyse, Gestaltung und techni schen Entwicklung zu beteiligen. Globales Netzwerk Synopse Das gesamte Netzwerk bildet den Hintergrund, auf dem sich die Interaktion mit den Texten abspielt. Einzelne Nodes können selektiert werden, woraufhin sich ein Textfenster öffnet, in dem markierte Text stellen und ihre Verbindungen angezeigt werden. In einem festen Set von eng aufeinander bezogenen Texten bietet das Netzwerk keinen informationel len Mehrwert. Die Texte werden parallel lesbar dargestellt. In Beziehung stehende Stellen werden her vorgehoben und Informationen zur Relation angezeigt. Dieses UI entspricht der Methode Synopse. Die zu einem Korpus gehörenden Texte werden als Balken radial angeordnet und Verbindungen zwi schen ihnen als Bogen angezeigt. Die Selektion eines Balkens öffnet eine lesbare Textansicht rechts daneben, wo mehrere Texte dargestellt werden können. Dieses UI eignet sich zum Beispiel für Korpus- oder Werk-Analysen. Ein Text steht im Zentrum. Neben seiner Darstellung als Volltext ist der Ausschnitt des globalen Netz werkes zu sehen, der die Verbindung zu anderen Texten betrifft. Über das Netzwerk lassen sich seine Verbindungen zu ihnen explorieren und in Beziehung stehende Texte als Fenster öffnen. Über einen Slider lässt sich der Ausschnitt des Netzwerkes über die direkten Nachbarn hinaus vergrößern. Diese Konfiguration ist besonders nützlich bei Annotation und Analyse intertextueller Relationen einzelner Textstellen. Für hermeneutische Zugänge und Close-Reading-Ansätze ist sie besonders wertvoll. Korpus-Netzwerk Text und Netzwerk M I T M A C H E N ? uni.ms/intertextor


Non-Cognitive Predictors of Student Success: A Predictive Validity Comparison Between Domestic and International Students OSIRIS - A 20 ton liquid scintillator detector as a radioactivity monitor for JUNO PRESENTER: Alexandre Göttel for the JUNO collaboration Motivation JUNO's requirements on LS contamination: - 10^-15 for JUNO reactor neutrinos (IBD) - 10^-17 to 10^-16 for JUNO solar neutrinos Provide LS radioactivity data during commissioning of purification systems Detector Radioactivity levels are too low for “standard” detectors → 20 tons of LS surrounded by 64 iPMTs. Enclosed in a 9*9 meter cylinder of ultra-pure water. LS flows through OSIRIS in batches. iPMTs ●“Intelligent PMT” ●Digitization in PMT base ●→ Same cable for power & readout ●→ High signal quality ●→ Trigger-less readout scheme ● ●OSIRIS is equipped with 64 iPMTs + 12 veto iPMTs Simulation Calibration Analysis Results Assuming 100 counts/day of radon on day one: Reactor requirements met in < 1 week Solar sensitivity region reached in ~ 20 days Additional limits on background for JUNO Standalone C++ software framework based on Geant4 (10.02.p03). Full detector simulation with all relevant geometry and physical processes. Deployed via git & cmake → Fast simulation → Parallel development Optical photon simulation → In line with JUNO → Quenching → Cherenkov light → Wavelength dependent Biasing external gammas An external laser will send ps pulses with a wavelength of 420 nm. 20 diffusors, controlled with fiber switches, can distribute the light over all PMTs. Source calibration Two capsules containing radioactive isotopes will be lowered into the LS volume. They will be used to calibrate the energy scale and monitor long-term changes in the detector response. An additional capsule will contain a LED for additional timing calibration. Laser calibration → Charge → s.p.e. → Timing → Energy What is being calibrated? OSIRIS exploits the fast coincidence of Bi-Po decays to monitor U-238 and Th-232 levels in LS. The analysis is very sensitive to radon contamination in the liquid scintillator, as radon events are indistinguishable from Uranium and Thorium events. After the low-level data analyses and the position/energy reconstructions are performed, a series of cuts are applied. One obtains the following energy spectra (here from simulations). The signal events are obtained through time- coincidences from events in the energy windows in the plots below. On a pure LS sample: Preliminary additional radon contamination estimation:


Understanding the Benefits of Probiotic Formula for Gut Health The gut microbiota, a diverse community of microorganisms residing in our gastrointestinal tract, plays a crucial role in maintaining our overall health. Probiotics, live microorganisms with potential health benefits, have garnered significant attention for their ability to promote gut health. In this article, we will delve into the science behind probiotic formulas, exploring their mechanisms of action and scientific evidence supporting their use in maintaining a healthy gut. Understanding Gut Health and the Gut Microbiota The gut microbiota consists of trillions of microorganisms, including bacteria, viruses, fungi, and other microbes. These microbes coexist in a delicate balance, forming a complex ecosystem that interacts with our bodies in numerous ways. A healthy gut microbiota is associated with proper digestion, efficient nutrient absorption, and a robust immune system. The Role of Probiotics Probiotics are strains of beneficial microorganisms that, when consumed in adequate amounts, confer health benefits to the host. They can exert their effects through various mechanisms, including: Gut Microbiota Modulation: Probiotics can influence the composition and diversity of the gut microbiota. They help restore balance in cases of dysbiosis, promoting the growth of beneficial bacteria while inhibiting the growth of harmful pathogens. Production of Bioactive Compounds: Probiotics can produce bioactive compounds, such as short- chain fatty acids and antimicrobial substances. These compounds support gut health by providing nutrients to the gut cells, enhancing gut barrier function, and inhibiting the growth of harmful microorganisms. Immunomodulation: Probiotics interact with the immune system, stimulating the production of immune-modulating molecules and promoting the development of a balanced immune response. This immune modulation can help alleviate inflammation and enhance immune defense against pathogens. Scientific Evidence for Probiotic Formulas Numerous scientific studies have investigated the efficacy of probiotic formulas in promoting gut health. Some key findings include: Gastrointestinal Disorders: Probiotic formulations have demonstrated benefits in managing various gastrointestinal disorders, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and antibiotic-associated diarrhea. Immune Support: Probiotics have been shown to enhance immune function, reducing the risk of respiratory tract infections and allergic conditions.


SITUACIÓN DE OBESIDAD EN LOS NIÑOS de 5° grado de primaria de las Escuelas Adventistas del Sur de Sonora Víctor Hugo Solís Valladares, Ph.D.; Helen Joceline Vidaña Espinoza. UNIVERSIDAD DE NAVOJOA A partir de los 10 a 12 años (5° o 6° de primaria) es el inicio del desarrollo sexual y corporal, por lo que la nutrición juega un papel muy importante en el desarrollo de los escolares. El objetivo de la investigación es conocer el estado nutricional de los niños que cursan el quinto grado en la escuela primaria del “Colegio del Pacífico” en Navojoa y “Colegio Obregón” en Cajeme, ambos en el sur de Sonora, México. La investigación es cuantitativa, transversal y descriptiva. La población analizada corresponde a 44 escolares (28 Colegio del Pacífico y 16 Colegio Obregón). Se utilizó una báscula digital para determinar el peso (± 0.5 gr). Para la toma de la talla se utilizó un estadímetro mecánico (SECA 216). Se desarrolló una ficha para recolección de los datos demográficos. Los datos recolectados se valoraron con las tablas de la CDC para peso y edad. Los resultados obtenidos revelan que el 72.73% (32 alumnos) tienen un estado de nutrición normal de acuerdo al peso para la edad; el 20.45% (9 alumnos) presenta obesidad y el 6.82% (3 niños) bajo peso. En términos generales un 72.73% de escolares tiene un estado nutricio normal, pero el 27.27% restante presenta un grado de obesidad o desnutrición; condiciones que deben atenderse a través de la implementación de programas educativos basados en nutrición escolar. Es por eso que la evaluación nutricional oportuna en las escuelas, puede ayudar a prevenir padecimientos en el futuro. La obesidad, en palabras de Rodríguez (2003) se define como exceso de grasa corporal o tejido adiposo. La obesidad es un problema serio de salud a nivel mundial y que se asocia a las principales causas de morbimortalidad. Actualmente se estima que el número de personas obesas asciende a 300 millones y un número mayor en países desarrollados o en vías de desarrollo (Montero, 2002:325-330). La Organización para la Cooperación y el Desarrollo Económicos (OECD) declara que a nivel mundial México se encuentra en el segundo lugar de obesidad en adultos con un 32% de su población, el primer lugar se lo lleva Estados unidos con 38.2% de su población. La región con más presencia de obesidad en México es la región norte que comprende los estados de Baja California, Baja California Sur, Chihuahua, Coahuila, Durango, Nuevo León, Sinaloa, Sonora y Tamaulipas, siendo Sonora el que tiene mayor prevalencia de obesidad infantil a nivel nacional con un porcentaje de 36.9% (ENSANUT, 2012). La obesidad en la niñez o en la adolescencia refiere Reyna (2012), tiene un impacto negativo en la salud y conlleva a una serie de enfermedades en esa etapa y, después cuando sea adulto incrementa el riesgo de enfermedades como dislipidemias, diabetes mellitus tipo 2, hipertensión, enfermedades cardiovasculares, ciertos tipos de cáncer. El propósito de la investigación fue conocer si está presente la condición de obesidad en los niños de 5° de primaria de las escuelas adventistas del sur de sonora, para tomar medidas correctivas, tales como orientación nutricional a los padres y maestros, a fin de que se logre mejorar la salud de los niños y en consecuencia, sean adultos sanos. La investigación es de carácter cuantitativo (Hernández, 2010) ya que se recopilará información numérica(peso y estatura) de cada niño de 5° de primaria de las escuelas adventistas del sur de Sonora, a fin de obtener datos medibles para dar una valoración medible del porcentaje de obesidad existente en la población analizada. Es descriptiva ya que, según menciona Gómez (2006), se evidencia una condición poblacional, en este caso, el porcentaje de obesidad de los estudiantes de 5° de primaria de los colegios adventistas del sur de Sonora. Por último, Heinemann (2003) comenta que al recopilar los datos una sola vez en un momento determinado, se habla de un análisis de corte


Study of the toxicity and the antimicrobial activity of different forms of ZnO nanoparticles: ZnO nanoparticles linked to graphene, pristine ZnO nanoparticles and ZnO nanoparticles doped with Mn Natalia Fernández-Pampín1 , Rocío Barros1, Sonia Martel Martín1 , Olavo Cardozo2,3, Andreas Stingl2, Patricia Farias2,4 , Alejandra García-Gómez5, Elisa Peña5 , Carlos Rumbo1, Juan Antonio Tamayo-Ramos 1 1 International Research Centre in Critical Raw Materials-ICCRAM, University of Burgos, Plaza Misael Bañuelos s/n, 09001, Burgos, Spain 2 PHORNANO Holding GmbH, Kleinengersdorferstrasse 24, 2100 Korneuburg, Austria 3 Post-Graduate Program on Electrical Engineering, Federal University of Pernambuco, Cidade Universitaria, Recife 50670-901, Brazil 4 Post-Graduate Program on Material Sciences, Federal University of Pernambuco, Cidade Universitaria, Recife 50670-901, Brazil 5 Gnanomat S.L., Campus Cantoblanco, Madrid Science Park, c/ Faraday 7, 28049, Madrid, Spain Contacts: nfpampin@ubu.es, crumbo@ubu.es, ja.tamayoramos@gmail.com ¡ Zinc oxide nanoparticles (ZnO NPs) have a multiple applications due to their special physico-chemical and antimicrobial properties. Moreover, they are inexpensive and less cytotoxic than others metal nanoparticles. The increasing use of the ZnO NPs in different sectors has raised concerns about their potential risks for the workers, consumers and environment. The posible toxic effects of different zinc oxide nanomaterials (G-ZnO, ZnO and ZnO:Mn) on the respiratory system and their irritant potential were evaluated. The antimicrobial activity of G-ZnO, ZnO and ZnO:Mn was analysed against Gram positive (methicillin-resistant S. aureus and vancomycin- resistant E. faecium) and Gram negative (A. baumannii and P. aeruginosa) bacteria. by reconstructed 3D human epidermal Materials • Graphene-zinc oxide nanomaterial (G-ZnO), ZnO and ZnO:Mn NPs Biological models A549 cells Reconstructed human epidermis (RhE) Gram positive and Gram negative bacteria Assays The effect of different concentrations of G-ZnO NPs on the A549 cell viability was evaluted by the MTT and neutral red (NR) assays, as well as the production of reactive oxigen species (ROS). On the other hand, the potential irritant of ZnO and ZnO:Mn NPs was determined using a RhE model. Moreover, the antimicrobial properties of the different ZnO NPs were studied in Gram positive and Gram negative bacteria by the determination of the minimun inhibitory concentration (MIC) following the CLSI guidelines. ¡ A549 cells MTT NR ROS RhE model S. aureus E. faecium A. baumannii P. aeruginosa G-ZnO ˃ 256 ˃ 256 ˃ 256 ˃ 256 ZnO ˃ 256 ˃ 256 ˃ 256 ˃ 256 ZnO:Mn ˃ 256 ˃ 256 ˃ 256 ˃ 256 Minimum inhibitory concentration (µg mL-1) #514 ¡ Introduction • The results obtained in the MTT assay showed that the G-ZnO produced a reduction of the cell viability after 24 h of treatment, while this reduction was less stronger in the NR assays. • G-ZnO NM caused a increased in the production of ROS in the studied exposure conditions. • According to the EU and GHS classification (Category 2 or Category 1), an irritant is predicted if the mean relative tissue viability of three individual tissues exposed to the test substance is reduced below 50% of the mean viability of the negative controls. Following this criteria, ZnO and ZnO:Mn NPs can be considered as non-irritant in the conditions tested. • None of the different ZnO NPs showed antimicrobial properties in the selected conditions, being their MICs ˃ 256 µg mL-1. Materials and Methods Results Conclusions