Rapid Characterisation of hERG Kinetics Using Optimised Protocols on a High-Throughput System Chon Lok Lei1, Michael Clerx1, David J. Gavaghan1, Liudimila Polonchuk2, Gary R. Mirams3, Ken Wang2 1. Computational Biology, University of Oxford, UK; 2. Pharma Research & Early Development, Roche, Switzerland; 3. Centre for Mathematical Medicine & Biology, University of Nottingham, UK chon.lei@cs.ox.ac.uk [1] Beattie et al. (2018) J. Physiol. [2] Traynelis (1998) J. Neurosci. Methods [3] Sherman et al. (1999) Biophys. J. 0 2 4 6 8 10 12 14 100 0 Voltage [mV] A Calibration B 0 2 4 6 8 10 12 14 20 0 20 Current [A/F] data model fit to data Time [s] Validation 1 Validation 2 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 50 0 Voltage [mV] Validation 3 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 50 0 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 50 0 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0 5 10 Current [A/F] 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 Time [s] 0 10 20 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0 5 10 Voltage [mV] 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 50 0 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 Time [s] 50 0 Voltage [mV] Time [s] Current [A/F] 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 0 10 data model prediction 40 20 0 20 40 0.0 0.5 1.0 Normalised Current Voltage [mV] Validation 4 Validation 5 0 1 2 3 4 p1 0 2 4 1e2 40 60 80 p2 0 1 2 0.0 0.1 0.2 0.3 0.4 0.5 p3 0 1 2 1e3 30 40 50 60 70 p4 0.00 0.25 0.50 0.75 1e1 200 300 400 500 600 p5 0.0 0.5 1.0 1.5 Normalised frequency 1e 1 10 20 30 40 50 p6 0 1 2 3 20 40 60 p7 0.0 0.5 1.0 1.5 20 25 30 35 40 p8 0 1 2 3 0 2000 4000 6000 gKr 0 1 2 1e 1 1 2 3 4 5 6 noise 0.0 0.5 1.0 1.5 1e2 0 2 4 1e 4 0 2 4 6 1e 1 0 1 2 3 1e 2 0.0 0.5 1.0 1e1 0 2 4 1e 2 0 2 4 1e 3 0 2 4 Probability density 1e 2 0 1 2 3 1e 2 0.0 0.5 1.0 1e 1 3.5 Model Parameters Correlation 3.3 Variability Across Experiments 3.2 Model Validation 3.1 Experimental Design / Model Training/Fitting Hierarchical Model Structure 1. Introduction Variability in hERG Kinetics References Fig 2: An optimised protocol that is designed for high throughput machine to recover model parameters. It shows the actual experimental measurement and the fitted model. Fig 3: Independent experimental measurements of the same cell to use as model validation. Here we used both 'traditional' protocols (Validation 4, 5) and new physiologically inspired [1] protocols (Validation 1-3) which are the AP-like, EAD-like and DAD-like waveforms. We repeated the same experiment on the same cell-line and recorded 65 individual cell measurements. Can we capture experiment-to- experiment variability? Fig 5: A hierarchical Bayesian model (HBM) was used to capture experiment- to-experiment variability. Marginal distributions of each experiment are shown, which reveal the variability between experiments. The posterior predictive distributions from the HBM are shown in red. Hodgkin-Huxley formulation 2. Cardiac hERG Channel Model 3.4 Consideration of Experimental Error Model The above analyses have assumed experiments were done 'perfectly'. That is we have assumed our input of the command voltage V was what the cell experienced as the membrane voltage Vm during the experiment. However, this might not be exact [2, 3]. Therefore we have also considered the possible error source in the experiment, as error model, to give: where 'mechanistic model' is our IKr model and 'noise model' is a simple Gaussian/white noise model. Fig 6: The 95% C.I. contour plots of the inferred covariance matrix, together with each parameter values. It shows a compar- ison of the parameter varia- bility (blue) and the effect of the voltage error model (red) on synthe- tic data. Fig 5: A schematic of the full hierarchical Bayesian model, which is a multi-level modelling technique that combines individ- ual measures (lower level) as a group (top level). Prior distributions are specified for the , , . This allows us to combine multiple experiments into one causal structure. Notation: 4. Experimental Methods This is not the end! Acknowledgements Fig 1: A simp


Towards a datafication of Antwerp street life? Co-creating a dataset of 100.000 pages of handwritten police reports (1876-1945) INCIDENT BOOKS OF ANTWERP = Reports of daily and nightly police patrols on district level dealing with prosecuted and non- prosecuted crime ▻Serial character = consistent registration over time of • personal data of people involved: name, profession, date and place of birth, place of residence • incident: location, date, time of day, detailed description • follow-up of the incident Coming soon: open access publication of dataset and HTR-model Contact: Lith Lefranc (Lith.Lefranc@UAntwerpen.be) PhD advisors: Ilja Van Damme and Mike Kestemont RESEARCH POTENTIAL ▻Rare window on bottom-up practices and lived experiences of ordinary people ▻Data-driven approach to history of local policing, working-class history, history of mentalities, gender and sexuality history, history of the everyday, youth and family history… ▻Dataset specifics • 289 incident books • 97,498 images • ± 30,500,000 words of (automatic) transcriptions in various file formats • Languages: French and Dutch • 11 districts of Antwerp • Time span: 1876-1945 Training Material #Words CER Ground truth 78,581 12.3% Ground truth + best 1/3 students 370,206 9.0% Ground truth + best 2/3 students 734,857 8.0% Ground truth + all students 978,672 7.9% HANDWRITTEN TEXT RECOGNITION ▻Challenges: • Numerous different handwritings • Bilingual: French + Dutch • Complex layout (esp. skewed text) ▻HTR-model training: combination of gold with semi-gold standard training material (students) – created in Transkribus ▻Error analysis: • Exclusion of skewed text • Exclusion of punctuation, capital letters, whitespace in CERberus Relaxed CER: 4.7% 0 5000 10000 15000 20000 25000 30000 1876-1882 1883-1889 1890-1896 1897-1903 1904-1910 1911-1917 1918-1924 1925-1931 1931-1938 1939-1945 Number of pages Sample periods Distribution by sample period 1 May 1885 Mr Sergoynne draw up an official report D At 9 ½ hours in the evening I saw that the maid from the house N° 57 in the Leopoldst was beating rugs against the wall of the guesthouse when I came over she ran away inside the house and didn’t come outside any more (she caused a flood of dust) Broes, Dymphna, 16 years, born in Minderhout, maid, residing in Leopoldstr 57 Because she was so young and she didn’t know better, I didn’t follow up on this.


Correlations in molecular content of oxygen-rich AGB and RSG stars Sofia Wallström1, Leen Decin1, Carl Gottlieb2, Holger Müller3, Taïssa Danilovich1, Fabrice Herpin4, and the ATOMIUM collaboration5 1. Institute of Astronomy, KU Leuven, Belgium. 2. Harvard Smithsonian Center for Astrophysics, Cambridge, Massachusetts, USA. 3. I. Physikalisches Institut, Universität zu Köln, Germany. 4. Laboratoire d’astrophysique de Bordeaux, Université Bordeaux, France 5. https://fys.kuleuven.be/ster/research-projects/aerosol/atomium/atomium Background The ATOMIUM ALMA large project aims to establish the dominant physical and chemical processes in the winds of oxygen-rich evolved stars over a range of ini@al stellar masses, pulsa@on behaviours, mass-loss rates, and evolu@onary phases. Through high-resolu@on (~0.025" - 0.05") observa@ons in bands between 214 and 270 GHz, we have detected 286 molecular lines of 23 diﬀerent molecules and their isotopologues, in vibra@onal states up to v=5. The eventual unravelling of the complex chemistry of these sources will provide astrochemical knowledge that will strongly impact research on supernovae, protostars, interstellar clouds, ac@ve galac@c nuclei, etc. — environments in which it is far more diﬃcult to grasp the dust nuclea@on process. As a star@ng point for the chemical analysis, we have calculated Pearson's linear correla@on coeﬃcients between the molecular content of each source and its (circum)stellar parameters: mass-loss rate, expansion velocity, and pulsa@on type. Ini.al results We see some expected correla@ons with mass-loss rate: a higher wind velocity and molecular tracers of dense winds such as H2S, as well as the rarer Al-bearing molecules. Lower wind velocity, conversely, is correlated with the detec@on of H2O and to a lesser extent OH. Mira pulsator sources are correlated with detec@ons of a somewhat random list of molecules: SiS, CS, PO, AlF, and KCl. The metal oxides PO, TiO, and AlO are well correlated, as expected, though TiO2 is not. AlOH is beaer correlated with the metal halides, which are also nicely correlated with each other, with the excep@on of KCl. KCl also shows no correla@on with mass-loss rate, unlike the other metal oxides and halides. However, these outlier molecules tend to have fewer and weaker detected lines, which may explain the observed trends. All results should be treated as preliminary! Note that we also detect more carbonaceous molecules, such as HC3N and SiCC, as well as the nitrogen-bearing SiN, but only in the singular S-type star W Aql and hence they are not included in the correla@on table. VX Sgr and W Aql are the most line rich sources in our sample, with ~5.5 and ~3.8 lines/GHz, respec@vely. Correla.ons between sources: Table of linear correla@on coeﬃcients, colorized by value from green (1.0 = perfect correla@on) to pink (-1.0 = perfect an@-correla@on), calculated using values of mass-loss rate and expansion velocity, and designa@on as 0 or 1 in pulsa@on type (Mira or other) and molecular content (line detec@on at a 3σ level) Source Puls MLR vWind S Pav SRa 8.0E-08 9 T Mic SRb 8.0E-08 4.8 U Del SRb 1.5E-07 7.5 R Hya Mira 2.0E-07 12.5 RW Sco Mira 2.1E-07 11 SV Aqr LPV 3.0E-07 8 V PsA SRb 3.0E-07 14.4 U Her Mira 5.9E-07 15 pi Gru SRb 7.7E-07 30 AH Sco SRc 1.0E-06 23 W Aql Mira 3.0E-06 17.2 R Aql Mira 3.5E-06 8 KW Sgr SRc 5.0E-06 27 GY Aql Mira 6.0E-06 13.6 IRC-10529 Mira 1.0E-05 13 IRC+10011 Mira 1.0E-05 23 VX Sgr SRc 6.1E-05 24.3 Source table: The ATOMIUM sample of AGB and RSG stars, along with their pulsa@on type, mass-loss rate (in solar masses per year) and expansion velocity (in km/s), taken from the literature.


Shea Jiun Choo1, Sabariah Noor Harun2, Balamurugan Tangiisuran2, Chee Tao Chang3, Mohd Faiz Abdul Latif,4 Nor Aida Sanusi5 C-06 1.Taiping Hospital 2. School of Pharmaceutical Sciences, Universiti Sains Malaysia 3. Clinical Research Centre, Raja Permaisuri Bainun Hospital, 4. Taiping Health Clinic 5. Pharmaceutical Services Division, Perak State Health Department A MULTICENTRE RETROSPECTIVE COHORT STUDY ON TREATMENT OUTCOME OF VARENICLINE Characteristics (n=114) Frequency (%) Treatment duration (week), in mean ± SD 8.8 ± 3.3 Smoking abstinence rate Successful Unsuccessful 68 (59.6) 46 (40.4) Type of adverse events Frequency (%) Cardiovascular related Hospitalization Angina pectoris 2 (1.8) 1 (0.9) Neuropsychiatric related Altered behaviour Auditory hallucination 2 (1.8) 1 (0.9) Others Increased appetite Dizziness Dry mouth Nausea Abnormal dreams Insomnia Stomach discomfort Others 19 (16.7) 18 (15.8) 12 (10.5) 10 (8.8) 9 (7.9) 9 (7.9) 6 (5.3) 21 (18.5) Characteristics (n=114) Frequency (%) Age (years), in mean ±SD 46.0 ± 14.4 Gender Male Female 104 (91.2) 10 (8.8) Ethnic Malay Chinese Indian 70 (61.4) 17 (14.9) 27 (23.7) Number of cigarette smoked per day (sticks), in mean ± SD 17.0 ± 11.3 Duration of smoking (years), in mean ± SD 26.6 ± 14.9 Fagerstrom score 0 to 3 (Low dependence) 4 to 5 (Moderate dependence) 6 to 10 (High dependence) 42 (36.8) 28 (24.6) 44 (38.6) Attempts to quit Yes No 79 (69.3) 35 (30.7) Table 4: Logistic regression model predicting successful smoking abstinence Variables Adjusted odd ratio 95% CI P-value Number of cigarette/day 1.102 0.929, 1.103 0.785 Duration of smoking 0.800 0.639, 1.003 0.053 Fagerstrom score High Low-to-moderate Reference 1.033 0.164, 6.519 0.972 Without quit attempt 0.330 0.066, 1.657 0.178 Readiness to quit Pre-contemplation & contemplation Preparation & action Reference 5.145 1.005, 26.328 0.049 Treatment duration 2.445 1.735-3.445 <0.001 Adverse events 0.096 0.014, 0.644 0.016 Withdrawal symptoms 0.032 0.016, 0.835 0.032 NMRR-18-2984-44113 (IIR) ACKNOWLEDGEMENT We would like to thanks the Director General of Health, Ministry of Health Malaysia for his approval to present this study. REFERENCES 1. Cahill, K., et. al. 2013. Pharmacological interventions for smoking cessation: an overview and network meta‐analysis. Cochrane database of systematic reviews, (5). 2. Ware, J.H., Vetrovec., et al. 2013. Cardiovascular safety of varenicline: patient-level meta-analysis of randomized, blinded, placebo-controlled trials. American Journal of Therapeutics, 20(3), pp.235-246. 3. Anthenelli, R.M., et.al 2016. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. The Lancet, 387(10037),pp.2507-2520. Table 1: Demographic characteristics of patients Table 3: Adverse drug events experienced by patients Table 2: Treatment duration and rate of smoking abstinence


A new 2 km Sea Surface Temperature Atlas of the Australian Regional Seas (SSTAARS) Summary We use 25 years of Advanced Very High-Resolution Radiometer (AVHRR) data from NOAA Polar Orbiting Environmental Satellites received by six Australian and two Antarctic receiving stations to construct a detailed climatology of sea surface temperature (SST) at 20 cm depth around Australasia. • Raw scans have been accurately navigated • Only night-time nearly cloud-free data are used to reduce diurnal bias and cloud contamination • Irradiances have been processed and fitted to in situ drifter data following international GHRSST protocols to help reduce instrument bias • A pixel-wise (2km) climatology (with four annual sinusoids) and linear trend are fit to the data using a robust fitting technique • Monthly non-seasonal percentiles are also derived Validation • Used temperatures from coastal tide gauges and wave-rider buoys, not used to de-bias the satellite data (Figure 1a) • Climatology based on in situ observations was compared to SSTAARS • The major driver of difference is the distance between the in situ site and the nearest Atlas pixel (Figure 1b). • The more offshore wave-rider sites show very good agreement with the Atlas as they can be most closely collocated with an Atlas pixel • For co-locations within 3km, RMS errors are 0.2o C or less, and within 1km, 0.1o C or less, comparable to the average drifter matchup errors Susan E. Wijffels1,2, Helen Beggs3, Christopher Griffin3, John F. Middleton4, Madeleine Cahill1, Edward King1, Emlyn Jones1, Ming Feng1, Jessica A. Benthuysen5, Craig R. Steinberg5 and Phil Sutton6 Key phenomena revealed • Indonesian Throughflow warm advection (Figures 4 and 5) • Summer tidal drawdown over tropical shelves (Figures 6 and 7) • Tidally-driven reef-flat mixing (Figures 6 and 7) • Boundary current flows and their seasonality (Figures 8 and 9) • Cross-shelf gradients of variance due to mesoscale eddies (Figure 9) • Suppression of the annual cycle by warm advection along the Lleeuwin Current pathway (Figures 8 and 9) Data Access SSTAARS Atlas files: https://portal.aodn.org.au/search?uuid=79c8eea2-4e86-4553-8237-4728e27abe10 IMOS AVHRR daily night-time L3S data used as input: https://portal.aodn.org.au/search?uuid=79c8eea2- 4e86-4553-8237-4728e27abe10 Figure 1: a) Locations of long and relatively continuous near surface in situ temperature records from either coastal tide gauge sites (SL) or offshore wave-rider sites (WR); b) RMS difference in the seasonal cycle between the in situ and Atlas estimates as a function of distance between the in situ measurement site and the nearest Atlas pixel. 1 CSIRO Oceans and Atmosphere, GPO Box 1538 Hobart, TAS 7001 Australia 2Woods Hole Oceanographic Institution, MS #29, 266 Woods Hole Road, MA 02540, USA 3 Bureau of Meteorology, Docklands, VIC 3008, Australia 4 South Australian Research and Development Institute, West Beach, SA 5024, Australia 5 Australian Institute of Marine Science, Townsville, QLD 4810, Australia 6NIWA, Wellington, New Zealand Coverage • The coverage for June and December is shown in Figure 3 in observation count per pixel • Sampling is very seasonally dependent, due to cloudiness • Pixels near Australia have more observations, with sampling dropping off with distance from Australian satellite receiving stations due to reduced reception of direct broadcast NOAA satellite data by these receivers. Figure 2: Estimates of the linear SST trend from 3/1992-12/2016: a) from the IMOS SST archive and b) from the NOAA OI V2 weekly SST. Units are oC/decade and the contour interval is 0.2C/decade. Grey stippled regions mark where the trend is smaller than 2 times the standard error (95% significance level). 25 Year Trends Figure 4 (top left): Climatological SST from the Atlas for the Indonesian Seas shown every 2 months. The colour scale is adaptive and changes every month to help better reveal spatial contrasts. Grey contours mark the 50m (thin) and 200m (thic


Potential CO2 storage sites Stenlille • The reservoir occurs within a domal closure and is overlain by a 300 m thick clay sequence of the Fjerritslev formation. • A 140 m thick upper Triassic Gassum sandstone formation 1500– 1600 m below the surface. • As of 2017, there are 14 injection and production wells as well as 6 observation wells. • Smooth operation of the natural gas storage site since 1989. • The geological setting at Stenlille is assumed to represent a good analog to the Havnsø structure since similar lithologies and burial depths for the Gassum formation are expected. • The average porosity (25%) and permeability (250 mD) in the Gassum sandstone reservoir at Stenlille represent good conditions for geological CO2 storage. • The Stenlille dataset is the most comprehensive onshore dataset in Denmark (cuttings descriptions, core analysis data, wireline logs, well completions reports, well test reports, seismic data, geochemical data, and historical records of injection and production rates of natural gas, as well as bottomhole and wellhead pressures and temperatures). Havnsø • One of the most prospective CO2 storage sites in Denmark. • Proximity of large CO2 emission sources: a biomass-fired power plant and a refinery close to Kalundborg; supplementary CO2 point sources in Copenhagen. • No wells have been drilled and only low-quality seismic data is available (new seismic was acquired in August-October 2022). Reservoir models • CO2-water isothermal model without geochemical reactions • Phase properties are modelled as functions of pressure. Stenlille • The model, covering approximately 7,760 x 3,570 x 137 meters, contains 119,634 active cells with properties, adjusted to represent faults and fractures. • The reservoir consists of 6 zones, separated by impermeable layers. • The model is history matched to natural gas injection/production and pressure data, which makes it a good candidate to model CO2 injection. Havnsø • The reservoir model is based on the Top Gassum map, obtained from seismic interpretation. • A uniform thickness reservoir of approximately 20,000 x 15,000 x 150 m has 4,959,998 active cells. • The distribution of rock properties follows the suggested depositional pattern from Stenlille. In a net-zero CO2 emission economy, the CO2 transportation and storage networks will need to accommodate fluctuations in CO2 feed- flows. This calls for a need to assess different strategies for temporary storage of CO2. The objective of the present work is to evaluate the efficiency of temporary CO2 storage in saline aquifers for the case of two geological sites in Denmark, Stenlille and Havnsø. Specifically, we study the sensitivity of CO2 recovery factor with regards to the parameters of the CO2-water relative permeabilities and capillary pressures. The results of the sensitivity study demonstrate a critical role of rock-fluid interactions and accurate reservoir characterization on the estimates of CO2 recovery. In all considered injection/production scenarios, the efficiency of temporary CO2 storage does not exceed 30%; achieving this recovery factor is only possible if a large amount of CO2 is injected in the reservoir for permanent storage (several hundred thousand tons for the considered cases). The duration of this initial CO2 injection is of the order of years so that the caprock integrity will not be compromised. Sensitivity study on CO2 recovery during temporary storage • Sampling the parameters of the saturation functions within the ranges from the literature. • Quantifying the impact of uncertainty in relative permeability and capillary pressure on the CO2 recovery factor (RF) during temporary storage. • Modelling CO2 injection in a vertical well, located at the top of the Stenlille and Havnsø structures. • Injection for 10 years with a constant bottomhole pressure control, followed by 10 years production with the constant topside pressure control. Stenlille • A large spread in CO2 recovery factors, depending


Seit ihrer Gründung im Jahr 1661 ist die Staatsbibliothek zu Berlin für die Öffentlichkeit zugänglich. In dieser Tradition sowie im Bewusstsein ihrer besonderen historischen Verantwortung steht die Staatsbibliothek zu Berlin zu ih- rer Verpflichtung, wissenschaftliches Wissen der Gesellschaft unbeschränkt und gleichberechtigt zur Verfügung zu stellen. Als Einrichtung der Stiftung Preußischer Kulturbesitz hat sie die Berliner Erklärung über den offenen Zugang zu wissenschaftlichem Wissen unterzeichnet. Deren Ziel ist es, Open Access zu be- fördern – also sowohl den offenen Zugang als auch die freie Nachnutzung von wissenschaftlichen Wissensbeständen einschließlich der diesen zugrunde liegenden Daten. In ihrer Funktion eines Zentrums der überregionalen Literatur- und Informationsversorgung sowie als größte wissenschaftliche Universal- bibliothek in Deutschland hat die Staatsbibliothek zu Berlin Open Access als ein zukunftsweisendes Handlungsfeld in den Blick genommen und zum festen Be- standteil ihrer strategischen Weiterentwicklung gemacht. Nicht zuletzt auch im Kontext der im Oktober 2015 beschlossenen Open Access-Strategie für Berlin hat die Staatsbibliothek zu Berlin verschiedene Themenbereiche identifiziert, in denen sie Open Access unterstützen kann. Sie engagiert sich daher für die  Digitalisierung und offene Zugänglich- machung ihrer urheberrechtsfreien Bestände,  Bereitstellung geeigneter Infrastrukturen für das Publizieren im Open Access,  Sicherung und Erschließung amtlicher Open Access-Veröffentlichungen,  Freigabe der von ihr erstellten bibliographischen Metadaten an die Allgemeinheit,  zielgruppenspezifische Beratung zu Fragen von Open Access und Open Science,  Transformation des wissenschaftlichen Publikationssystems. DIGITALISIERUNG UND OFFENE ZUGÄNGLICHMACHUNG URHEBERRECHTSFREIER BESTANDSSEGMENTE FREISTELLUNG BIBLIO- GRAPHISCHER METADATEN  verantwortet mit der Zeitschriftendatenbank in Koope- ration mit der Deutschen Nationalbibliothek den welt- weit größten Katalog für den Nachweis von Periodika  übergibt alle kooperativ erstellten Titeldaten der Zeit- schriftendatenbank als maschinenlesbare Linked Open Data der Public Domain  stellt ihre eigenen Katalogisierungsdaten unter der Cre- ative Commons-Lizenz CC0 der Allgemeinheit zur be- liebigen Nutzung zur Verfügung BEREITSTELLUNG VON INFRASTRUKTUREN FÜR DAS PUBLIZIEREN IM OPEN ACCESS SICHERUNG UND ERSCHLIESSUNG AMTLICHER OPEN ACCESS- VERÖFFENTLICHUNGEN  ist Depotbibliothek für Dokumente internationaler Organisationen sowie offizielle Sammelstelle für Publikationen öffentlich- rechtlicher Einrichtungen der Bundesrepublik Deutschland  setzt sich in dieser Funktion für die langfristige Zugänglichkeit amtlicher elektronischer Publikationen im Open Access ein MITGESTALTUNG DER TRANSFORMATION DES WISSENSCHAFTLICHEN PUBLIKATIONSSYSTEMS  ist Teil des Finanzierungskonsortiums Knowledge Unlatched, das die Publikation sozial- und geisteswissenschaft- licher Monographien im genuinen Open Access ermöglicht  bekennt sich zum Ziel der Transformation des subskriptionsbasierten wissenschaftlichen Publikationssystems  spricht im Rahmen der Schwerpunktinitiative Digitale Information der Allianz der deutschen Wissenschaftsorgani- sationen Empfehlungen aus – u.a. zur Schaffung eines wissenschaftsadäquaten Open Access-Publikationsmarkts  verhandelt im Auftrag von Bibliotheken und Universitäten aus ganz Deutschland überregionale Lizenzen für elektronische Informationsangebote – unter Berücksichtigung möglichst liberaler Zweitveröffentlichungsrechte ZIELGRUPPENSPEZIFISCHE BERATUNG ZU FRAGEN VON OPEN ACCESS UND OPEN SCIENCE  informiert regelmäßig Forschende, Studierende sowie die interessierte Öffentlich- keit über den gegenwärtigen Strukturwandel der Wissenschaftskommunikation  organisiert u.a. Beratungsangebote zum wissenschaftlichen Publizieren, Workshops zum Forschungsdatenmanagement und Gastvorträge zu Open Science-Themen  engagiert sich mit ihren


COOPERATION POSTER CREATORS “Retro-editing” : The edition of an edition of the Karl Kraus legal papers IN THE PROJECT “INTERTEXTUALITY IN THE LEGAL PAPERS OF KARL KRAUS. A SCHOLARLY DIGITAL EDITION”, THE LEGAL PAPERS OF THE AUSTRIAN SATIRIST KARL KRAUS (1874- 1936) ARE BEING EDITED AND WILL BE PROVIDED DIGITALLY AND CONTEXTUALIZED WITH KRAUS’ OEUVRE AS A WHOLE. IN THIS POSTER, THE DIGITIZATION AND EDITING PROCESS OF THE PROJECT ARE DESCRIBED. AS THE PRECONDITIONS OF THIS DIGITAL EDITION ARE QUITE UNIQUE, THE POSTER FOCUSES ON THE PROJECT’S SPECIFIC INITIAL SITUATION, THE AVAILABLE MATERIAL, AND ITS PROCESSING AS WELL AS ON THE AIMS, GOALS, AND THE INTENDED OUTCOME (I.E. THE PLATFORM PROVIDING ACCESS TO THE DIGITAL EDITION) OF THE PROJECT. Vanessa Hannesschläger Austrian Centre for Digital Humanities / Austrian Academy of Sciences vanessa.hannesschlaeger@oeaw.ac.at INTERTEXTUALITY IN THE LEGAL PAPERS OF KARL KRAUS : A DIGITAL SCHOLARLY EDITION FWF project no. P 31138-G30 Introduction: Historical context While the Austrian Karl Kraus (1874-1936) is most commonly perceived as a satirist, writer, and editor of the magazine Die Fackel, his intensive preoccupation with justice was often observed and Walter Benjamin even declared: “No one will understand this man, unless one realises, that everything, without exception, language and purpose, for him happens in the sphere of law.”[1] Although Kraus’ attitude towards the courts in the Habsburg period had been predominantly critical, the constitutional reform of the Austrian Republic in 1919 and the abolition of death penalty marked a decisive break for the author. He especially welcomed the reform of the Press Law of 1922, which marked the beginning of a growing fondness for litigation. In the same year, Oskar Samek became his lawyer. In the course of the following 15 years (until Kraus’ death), they were involved in over 200 court actions together. Despite of Kraus’ commitment to the law, the influence legal proceedings had on his satire and the other way round was barely thoroughly researched – which was on the one hand due to the fact that cultural and literary historians often shy away from the interpretation of legal documents. Only Reinhard Merkel, a professor of criminal law, attempted to understand the connection of “Strafrecht und Satire” in Kraus’ Fackel from a jurisprudential point of view.[2] The second reason for the lack of research in this area is that the complex history of the Kraus papers, which were split up into several personal collections and taken to exile by Kraus’ (often jewish) friends and associates when they were forced to leave Austria during the time of the Nazi regime, was responsible for the long- lasting unavailability of the material documenting Kraus’ involvement with the law. The project described in this paper aims to bridge this gap by (re-)editing the papers documenting Kraus’ and Samek’s actions and making them available in an open access / open data / open source digital edition. Karl Kraus and Oskar Samek in court. The Kraus legal papers at the Vienna City Library. Initial position and starting point The material documenting Kraus’ and Samek’s court actions is held by the Vienna City Library. As this corpus consists of roughly 8000 sheets of paper, transcribing and editing all these documents in the course of a three year project with three persons (i.e. full time equivalents) staff would be unfeasible. Luckily, transcription is only a minor part of the project members’ tasks: In 1995, Hermann Böhm published the records of cases from the Karl Kraus papers as a ‘mixed edition’ (“Mischedition”) in four volumes[3] (of roughly 300 pages each). However, Böhm made a number of editorial decisions which are today out of date and not suited for a digital format, which is why a new edition of this material has become a desideratum among Kraus researchers as well as a wider research community interested in historical legal documents. While Böhm did a trem


Implementation of the “Essential-use” concept in chemical regulations Romain Figuièrea, Zhanyun Wangb, and Ian T. Cousinsa a: Department of Environmental Sciences, Stockholm University, SE-10691 Stockholm, Sweden b: Empa – Swiss Federal Laboratories for Materials Science and Technology, 9014 St. Gallen, Switzerland • Derogations refer mainly to the “availability of alternatives” component of the essential-use concept. • Category “Others reasons” can be divided into two sub-categories: • Reasons for which the essential-use concept would not affect the regulatory outcome, i.e., because the use already regulated, the use being out of scope, restriction not enforceable for the specific use, or substance found as impurities in the specific use; • Reasons for which the essential-use concept could affect the outcome, i.e., because negligible risk from the use, or the restriction costs outweigh the benefits, mentioned for ~20% of the derogations. Results Acknowledgements This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101036756. Partners Background Methods In the Montreal Protocol, a use is essential only if (A) it is necessary for the health and safety, or is critical for the functioning, of society; and (B) there are no available safer, technically and economically feasible alternatives. The EU Chemicals Strategy for Sustainability stipulates implementation of the essential-use concept under REACH to guide phase-out of the most harmful substances. Aims of the study To determine (1) whether the existing restriction of uses of harmful chemicals processes refer to elements of the essential-use concept; and (2) whether process changes are necessary to implement the concept in the decision-making. Analysis of the decisions on derogations to restrictions under Stockholm Convention and REACH processes following the READ approach (Dalglish et al. (2020)) to determine if relevant information to perform essential-use assessment was available. Lessons-learnt • No major changes in the REACH Restriction process are needed to implement the essential-use concept. • Previous decisions on derogations have been mainly based on the availability of alternatives. • The essential-use concept can bring a new perspective in decision- making. Components of the essential-use concept mentioned in decision-making on derogations to previous restrictions *: See separate section on REACH Authorisation process References: EU (2020), https://ec.europa.eu/environment/pdf/chemicals/2020/10/Strategy.pdf; Dalglish et al. (2020), DOI: 10.1093/heapol/czaa064; EU (2024), https://environment.ec.europa.eu/publications/communication-essential-uses-chemicals_en Contact romain.figuiere@aces.su.se REACH AUTHORISATION PROCESS • Authorisations are granted if (1a) risk is adequately controlled, or (1b) costs of ceased use outweigh the benefits, and (2) there no suitable alternatives available to the applicant (“Availability of alternatives” component) • Further work is needed to determine if enough information is provided in the applications to evaluate if the technical function is needed in final products, and whether it would fulfil the criteria to be considered as necessary for society • For 20 applications, the European Commission did not grant authorisation for part of the use applied for where “the specified key functionality is not necessary for the use” (“Technical function” component) Is the technical function needed in the final product? Technical function Does the use fulfil one of the criteria for being critical for society? Necessity for society Are acceptable alternatives lacking? Availability of alternatives Overview of the assessment of essentiality of a use as proposed by the European Commission 2% 15% 58% 40% 8% 15% 31% 88% 5% 100% 100% 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Technical function Necessity for society Availability of alternatives Other reasons REACH Authorisa


1Departamento de Física de la The lithium-age relation: Calibration with open clusters and associations Acknowledgments: Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme focus ID 188.B- 3002. These data have been obtained from the GES Data Archive. This work has made use of data from the European Space Agency (ESA) mission Gaia. We acknowledge financial support from the Universidad Complutense de Madrid (UCM) and by the Spanish Ministerio de Ciencia, Innovación y Universidades, Ministerio de Economía y Competitividad, from project AYA2016-79425-C3-1-P and PID2019-109522GB-C5[4]/AEI/10.13039/501100011033. Dependence with rotation, activity and metallicity. Li-age relation Candidate members for each cluster are selected from the Gaia-ESO Survey (GES) (Gilmore et al. 2012) iDR6 data based on the following criteria: RVs, Gaia astrometry (proper motions and parallaxes), gravity indicators - Kiel (logg vs Teff) and 𝛾 index diagrams -, [Fe/H] metallicity, and the position in the EW(Li) vs Teff diagram. As an example we show here the case of IC 2602 (PMs, CMD, EW(Li) vs Teff and 𝛾 index) and NGC 6705 (RV, Kiel diagram and [Fe/H] histogram): Selection criteria and cluster membership Abstract EW(Li) vs Teff: Plotting the lithium envelopes of IC 2602 (35 Myr), the Pleiades (78-125 Myr), and the Hyades (750 Myr) in a EW(Li) vs Teff figure, we can estimate age ranges and verify probable members (see Montes et al. 2001). Kinematic selection: We studied the RV distribution of each cluster by applying a 2-sigma clipping procedure and adopting a 2σ limit about the cluster mean yielded by the Gaussian fit to identify the most likely RV members. The Kiel diagram enables us to discard giant outliers (logg < 3.5) – some of them Li-rich giants (A(Li) > 1.5) – and other field contaminants. We used the PARSEC isochrones (Bressan et al. 2012), with Z = 0.019 and ages ranging from 1 Myr to 7 Gyr. For young clusters, we used the gravity indicator gamma (see γ index vs Teff diagram above) to discard giant contaminants before applying any kinematic and astrometric criteria. XI Reunión Científica de la SEA 5-9 September 2022, La Laguna [Fe/H] histograms also help rule out stars with metallicities too far away from the mean for each cluster. M.L. Gutiérrez Albarrán1, D. Montes1 , H.M. Tabernero1,2, J.I. González Hernández3,4, A. Frasca5, A.C. Lanzafame5, R. Smiljanic6, A.J. Korn7, S. Randich8, G. Gilmore9, et al. & GES Survey Builders In this work we used a series of open clusters and associations observed by the Gaia-ESO Survey (GES) to study the use of lithium abundances (Li I spectral line at 6708 Å) as an age indicator for pre- and main-sequence FGKM late-type stars. Previous studies of open clusters have shown that lithium depletion is not only strongly age dependent, but also shows a complex pattern with several other parameters, such as rotation, chromospheric activity and metallicity. Using the available data from both GES iDR6 and Gaia EDR3, we performed a thorough membership analysis and obtained lists of candidate members for 42 open clusters, ranging in age from 1-3 Myr to 4.5 Gyr. We then conducted a comparative study that allowed us to quantify the observable lithium dispersion in each cluster and study the influence of rotation, activity and metallicity in the lithium dispersion of the selected candidates. All this allowed us to calibrate a Li-age relation and create empirical lithium envelopes for 27 of of the 42 sample clusters, also constraining the LDB for those clusters in the 15-600 Myr age range. We used the rotational velocities (vsini), chromospheric activity indicators (EW(Hα)) and [Fe/H] metallicities provided by GES iDR6, as well as additional rotational periods (Prot) from the literature, including Kepler, K2 and TESS measurements. We confirmed the findings of former publications and observed that members with higher values of EW(Li) tend to be faster rotators a


TEMPLATE DESIGN © 2008 www.PosterPresentations.com • There were 3 cropping rotations in place at St. John: winter pea-winter wheat-spring wheat, cover crop- winter wheat-spring wheat, and fallow-winter wheat- spring wheat. These rotations were replicated so that every crop in each rotation was present in the field. This design was replicated 5 times in the same field. • Crops: winter wheat, spring wheat, winter pea, multi- species cover crop, and a fallow plot. • Sentinel seed station design: medium-sized Petri dish bottoms, filled with plasticine modeling clay with 20 seeds of each species pressed into the clay. • Closed treatment had 0.64 cm hardware mesh cage to exclude rodents and birds. Open treatment had no cage. • There were 4 sampling dates between July 5-Sep 26 2019 and the stations were left in the field for 7 days. • There were 20 replications of fallow, winter pea, and cover crop plots and 60 replications of winter wheat and spring wheat (n = 180). Seed Removal in Pacific Northwest Cereal Production Systems Jessica Kalin*, Sanford D. Eigenbrode* *Department of Entomology, Plant Pathology, and Nematology University of Idaho Introduction Methods Acknowledgements Research Objective: Test these four hypotheses using sentinel seed baits deployed into the replicated trial at St. John, WA. Results References • With projected changes in climate, Pacific Northwest growers are expected to modify their existing cereal- based cropping systems to more resilient, diversified systems. • Diversified systems include more crops, crop rotations, and cover cropping. • These cropping system modifications potentially increase vulnerability to weed and insect pests and this requires research. • Bromus tectorum (downy brome), Chenopodium album (common lambsquarters), and Anthemis cotula (Mayweed chamomile) are common weeds in the Pacific Northwest. [1-3] • “Landscapes in Transition” (LIT) is an inter-disciplinary, multi-institutional Coordinated Agricultural Project focuse on the development and adoption of sustainable and resilient cereal-based production systems in the Inland Pacific Northwest. • As part of LIT, we compared the removal rates by seed predators of these 3 weed species in 5 different crops in an ongoing replicated trial in St. John, WA. Plots at the field site in St. John, Washington. Seed trays placed ~1m apart. This study is part of a large collaborative project, Landscapes in Transition, funded through award #2017-68002-26819 from the National Institute of Food and Agriculture. Special thanks to Grace Overlie and Anna Stutz. Table 1. Partial ANOVA table with weed species, date, crop, treatment, and their interactions. Significant effects listed left. Highlighted effects are reported in detail here. Non-significant effects include: cage, weed species:cage, weed species:date:cage, and weed species:date:cage:crop. [1] Rydrych, D.J. 1974. Competition between winter wheat and downy brome. Weed Science, 22(3): 211-214. [2] Lyon, D.J., Burke, I.C., Hulting, A.G. & Campbell, J.M. 2017. Integrated management of mayweed chamomile in wheat and pulse crop production systems. Washington State University Extension Publications PNW695, pp 106. [3] Bohan, D.A., Boursault, A., Brooks, D.R., & Petit, S. 2011. National-scale regulation of the weed seedbank by carabid predators. Journal of Applied Ecology, 48: 888-898. **All photographs taken by Jessica Kalin unless stated otherwise. • The effects of weed species and crop were significant. The interaction between these effects (p < 0.01) is due to the low rates of lambsquarters seed removal compared to Mayweed and downy brome, especially in fallow. • Removal rates did not differ between open and closed stations (“cage” effect); the cage x crop interaction (p < 0.001) reflects the higher removal rates from caged stations in fallow and cover crop plots than in other crops. This was most evident on week 2 (wk2), accounting for the three-way interaction including date. • Removal of lambsquarte


We also studied analogous ensembles of hard spinners driven to rotate in opposite directions by an applied torque. The dynamics of the spinners are governed by the Langevin equation. Simulations were performed for 16,384 spinners. References 3. Coarsening dynamics of binary liquids with active rotation2 Bio-inspired colloidal machine: bringing colloids to life S. Sabrina1, A. Brooks1, M. Spellings2,3, S. C. Glotzer2,3,4 and K. J. M. Bishop1 1Department of Chemical Engineering, The Pennsylvania State University, University Park, PA – 16802. 2Department of Chemical Engineering, 3Biointerfaces Institute and 4Department of Material Science and Engineering, University of Michigan, Ann Arbor, MI – 48109. 1. Motivation This work was supported as part of the Center for Bio-Inspired Energy Science (CBES), an Energy Frontier Research Center (EFRC) funded by the U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences under Award # DE- SC0000989. 4. Comparison with microscopic model2 Funding and Affiliations Acknowledgements 5. Current work: shape-directed actuation of spinners The governing equations were solved numerically on a square domain (𝐿× 𝐿) with periodic boundaries using semi-implicit (Adams-Bashforth) Fourier spectral method. The continuum model suggests that activity-induced flows influence the coarsening dynamics depending on the strength of rotation (𝛼) and strength of frictional damping (𝛽). Spinners – converting energy into rotational motion – phase separate via diffusion under strong frictional damping1. 1. Diffusion-controlled passive coarsening is observed for any strength of active rotation under conditions of strong frictional damping (𝛽≫1). 2. Accelerated active coarsening is observed under conditions of weak rotation (𝛼≪1) and weak frictional damping (𝛽≪1). 3. Multi-scale structures emerge under conditions of weak rotation(𝛼≪1) and zero frictional damping (𝛽= 0). 4. Vortex-doublets emerge under conditions of strong rotation (𝛼≫1) and zero frictional damping (𝛽= 0). Vortex-doublet stronger rotation less friction stronger rotation stronger rotation Compositional field Velocity field Domain size 2. Background and continuum model2 spinners 𝑅~ 𝑡1/3 phase separated fluid Assumptions 1. Incompressible, Newtonian fluid 2. Bulk properties (e.g., density ρ, viscosity 𝜂) same in both phases 3. Low Reynolds number 4. Neglect Capillary forces Strength of rotation, 𝛼= 𝜏Ф𝑇𝜂 Strength of friction, 𝛽= 𝑏𝐿2 𝜂 Here,𝜏is driving torque, Ф is equilibrium composition, 𝑇is time of diffusive unmixing over 𝐿, 𝐿is interfacial thickness, and 𝑏is friction coefficient. 1. Nguyen et. al., Physical Review Letter (2014) 2. Sabrina et. al., (submitted 2015) 3. Squires and Bazant, Journal of Fluid Mechanics (2006) 4. Gangwal et. al., Physical Review Letter (2008) 5. Yan et. al., Optical Materials Express (2011). Capture & Convert Move & Transport Sense & Respond Reconfigure & Adapt Heal & Repair Grow & Replicate ‘Life-like’ synthetic materials from colloids Distributed Centralized Vs. Energy conversion into motion Features of distributed actuation • Robust to failure(e.g., muscles) • Intelligent and adaptive behavior(e.g., bacterial swarms) 𝛽= 102 𝛼= 10−2 𝛽= 0 𝛽=0 𝑡= 105 𝑡= 105 𝑡= 105 𝑡= 104 𝑡= 104 𝛼′ = 0.25 𝑡= 105 𝛽′ = 10−2 𝛽′ = 1 𝛼′ = 0.25 Passive Active R i i i i d m dt     v F v F (a) Synthesis of different shapes of spinners by photolithography. (b) Selective electroless Ag plating of spinners5 (c) Experimental setup of ICEP-driven spinners. Continuity Convective Cahn-Hilliard Navier-Stokes active driving force frictional damping Induced-charged electro-osmotic flow (ICEO) in ac electric field can actuate particles using their shape asymmetry and surface heterogeneity3. We are synthesizing spinners of complex shape actuated by external fields such as electric and acoustic fields. The design of ICEP-driven spinners of complex shapes is guided by COMSOL simulations. Induced- charge electrophoresis (ICEP)4 Angular velocity of di


Ophiuchus star-forming region (d ~ 135 pc) 12 Class I sources Herschel colour map Angular resolution: 0.4” (~50 AU) Continuum: 0.87 mm Molecular lines Disk tracers: C17O, H13CO+, C34S Warm chemistry: CH3OH Shock tracer: SO2 ALMA Observations The formation of low-mass stars involves physical and chemical processes that affect the evolution of the disk and set the initial chemical conditions for planet formation [1,2]. However, the physical processes on small disk scales (< 500 AU) are still not well understood [3,4]. How is the envelope material incorporated into the disk? Which physical and chemical processes dominate on disk scales? References: [1] Jørgensen, J. et al., 2008, ApJ, 683, 822; [2] Bergin, E. & Cleeves, I., 2018, haex.bookE, 137B.; [3] Jørgensen J. et al. 2009, A&A, 507, 861; [4] Yen H.-W. et al. 2015, ApJ, 799, 193; [5] Artur de la Villarmois, E. et al. 2019, A&A, 626, 71; [6] Kenyon, S. J. & Hartmann, L. 1995, ApJS, 101, 117. 100 200 300 400 0 3 6 9 12 15 18 21 Tbol [K] Lbol [L⊙] Class I/II Class I Class 0 Decreasing C17O and C18O Colder SO2 No lines on-source C17O SO2 Mass evolution Linear correlation between luminosity and protostellar mass gives Ṁacc = 2.4 ± 0.6 ⨯ 10-7 M⊙ yr-1 for Class I sources [5]. A constant Ṁacc cannot explain the observed luminosities and protostellar ages → Episodic accretion bursts: accretion rate varies with time and the protostar gains a significant amount of material in a short period of time [6]. Chemical evolution Chemical differentiation between C17O and SO2. C17O traces high gas column densities and is detected towards the youngest sources. Warm, compact, and high velocity SO2 emission is related with high luminosities and, therefore, high Ṁacc. ˙Macc = LbolR⋆ GM⋆ Results - A typical protostar will spend most of its lifetime in a quiescent state of accretion. - SO2 may be tracing accretion socks in the envelope-disk interface and highlighting sources with high accretion rates. The formation of disks results in characteristic chemical imprints. Introduction Conclusions The physical and chemical fingerprint of planet-forming disks Elizabeth Artur de la Villarmois* (elizabeth.artur@nbi.ku.dk), Jes Jørgensen, Lars Kristensen, Ted Bergin, Daniel Harsono, Nami Sakai, Ewine van Dishoeck & Satoshi Yamamoto *Niels Bohr Institute & Centre for Star and Planet Formation - University of Copenhagen 0.5 pc


Mercury Target Neutrinos 24m Baseline Iron Shielding Proton Beam π+ μ+νμ μ+ e+νμ νe K+ μ+νμ 17 Tons GdLS 30 Tons LS Veto IBD νe+p → e++n n+Gd → Gd+γ Prompt Delayed,𝜏≈28μs 96 inward looking 24 outward looking 120 10-inch PMTS J A N U S J A N U S J A N U S J A N U S J A N U S F O N T U S Large PMT Pulse Single PE PMT Pulse Custom Analog Proto-board TI ADS54J66 ADC Eval Board Analog & ADC Proto-board Xilinx Kintex Ultrascale Dev Board JANUS PCB design is complete JANUS : 32 Channel DAQ Board ... ... ATCA Backplane Global Bus PMT Data (Ethernet) Energy Sum (Serial 10Gbps) SFP+ Global Trigger Energy Sum (Serial 10Gbps) SFP+ PMT Data (Ethernet) Process Data and Triggers Digital (Serial) FPGA 1 Xilinx Kintex Ultrascale JESD204B FPGA 0 Xilinx Kintex Ultrascale 32 PMT Channels Analog Differential Signals Condition the PMT Signals Digitize the Waveforms ADC 7 500 MHz, 14-bit ADC 0 500 MHz, 14-bit ADC 3 500 MHz, 14-bit Frontend Analog Transceiver Transceiver Global Clock ADC 4 500 MHz, 14-bit FONTUS : Trigger Board FPGA Xilinx Kintex Ultrascale ATCA Backplane Energy Sum (Serial 10Gbps) Clock Front Panel Beam Signal External Triggers Global Trigger Global Bus Trigger Info (Ethernet) J A N U S J A N U S J A N U S J A N U S J A N U S F O N T U S 104 105 106 107 Neutrino Flux (Arb.) µ π K -600 -400 -200 0 200 400 600 800 1000 Time (ns) 0 20 Current (A) ×25Hz Beam Pulses Process Trigger Data to Produce Triggers Proto-board that can emulate both JANUS & FONTUS functionality is being produced. Pending testing and production of the final JANUS & FONTUS PCBs commissioning of the DAQ will begin Fall 2020. Once this design has been sucessfully deployed for JSNS2 we hope to demonstrate this as a "one size fits all" DAQ solution for medium- scale liquid scintillator detectors. The 14-bit resolution & large dynamic range provides sensitivity to high energy neutrinos, e.g. KDAR neutrinos, without losing single- PE sensitivity. The upgrade DAQ will be hosted within an ATCA shelf with 5 DAQ boards (JANUS) and one trigger board (FONTUS). Design can be expanded to fit possible future needs. Tests of the analog circuitry have demonstrated its ability to produce a differential copy of the input with excellent signal integrity. The FPGA based trigger allows event selection based on known event timing relations and the flexibility to design trigger logic specific to the physics of interest. Expected data readout rate is 1 Gbps per FPGA. The electronics will need to trigger based upon timing signals from the beam facility as well as event energy and timing conditions. Our system will leverage modern FPGA and telecom electronics to meet these requirements. The J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source (JSNS2) began taking data with DAQ electronics donated by the Double Chooz experiment. The Double Chooz electronics, however, were not designed for a beam based experiment and are not sensitive across the entire energy range of interest for JSNS2. I have been working, as part of a team, to develop upgrade electronics that will be better suited to JSNS2's energy and timing requirements. The upgrade electronics will enhance our physics capabilities by providing a excellent efficiency and resolution over a large energy range. Firmware testing and development underway using commercial and custom bench-top electronics. Beam Neutrino Production: Spectrum & Timing JSNS2 Detector & Primary Physics Interactions The Benefit of 14-bit Resolution The Design and Development of the JSNS2 DAQ Upgrade Eric Marzec (marzece@umich.edu) For the JSNS2 Collaboration JSNS2 Design Development


Fabrication of Lightweight Aluminium Metal matrix composites and validation In Green Vehicles FLAMINGo is a H2020 project funded under the LC-GV-06-2020 topic, aiming to the development of high-performance lightweight Aluminum composite materials thanks to a novel metallurgical and forming combined approach for making automotive parts. The FLAMINGo Project aims to manufacture strengthened Aluminium Metal Matrix nano-Composites, Al-MMnC, with enhanced properties in terms of strength and stiffness, compared to the existed Al alloys used in Green Vehicles. Nanoparticles & AI masterbatches Topology Optimisation Foundry Primary & Secondary Aluminium LCA/LCCA SAFETY LPDC, HPDC, GSC, DC Extrusion FieldTest Recycling WEIGHT SAVING REDESIGN LIGHTER ENGINE SMALLER BATTERY PACK THE PARTNERS THIS PROJECT HAS RECEIVED FUNDING FROM THE EUROPEAN UNION’S H2020 PROGRAMME UNDER THE GRANT AGREEMENT NO. 101007011 @FLAMINGoProjectH2020 @FLAMINGoPH2020 @FLAMINGo Project H2020 info@flamingo-project.eu www.flamingo-project.eu CONNECT WITH US


Objective TERMINUS addresses the challenge of unlocking the recycling and reuse of flexible multi-layer and multi- compound packaging through the design of new formulations with smart enzyme-containing adhesive or tie layer polymers. After a specific trigger, the enzyme will start degrading the polyurethane-based adhesive (PUR) or tie layer (TL), thus enabling the delamination of the different layers of packaging, which can then be recycled. Multilayers packaging recycling: the Terminus strategy TERMINUS has received funding from the European Union’s Horizon 2020 research and innovation programme, under grant agreement number 814400. This presentation refects only the views of the authors. European commission and Research Executive Agency are not responsible for any use that may be made of the information it contains. A. Romano, G. Totaro, A. Celli, C. Gioia, N. Raddadi, G. Zanaroli, L. Sisti Dept. of Civil, Chemical, Environmental and Materials Engineering, Alma Mater Studiorum Background Multi-layer packaging films are largelyexploited in the food industry, because they extend the lifetime of goods, helping to reduce food waste, but due the multi-material structure, these material are unrecyclable and currently 100% of multi-layer packaging is incinerated or landfilled, only for beverage cartons recyclability is demonstrated in practice and at scale. in-built Triggered Enzymes to Recycle Multi-layers: an Innovation for Uses in plastic-packaging SELECTION IMMOBILIZATION and TRIGGERING INCORPORATION Strategy of the hybrid systems into the adhesives of enzymes of the most active enzymes for adhesives 15% improvement in economic efficiency of end-of-life management 80% reduction of landfilling for multi-layer plastic packaging 55% reduction of overall plastic landfilling 65% decrease in the overall CO₂ footprint Expected Results


This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 824603. @ACTION4CS #ACTION4CS https://actionproject.eu Participant motivation to engage in a citizen science campaign: the case of the TESS network Gloria Re Calegari (Cefriel - gloria.re@cefriel.com), Irene Celino (Cefriel - irene.celino@cefriel.com), Mario Scrocca (Cefriel - mario.scrocca@cefriel.com), Jaime Zamorano (UCM - jzamorano@fis.ucm.es), Esteban González Guardia (UPM - egonzalez@fi.upm.es) The contents of the poster reflects the author’s views. The European Commission is not liable for any use that may be made of the information contained therein. Survey design • define the research question • define investigated factors • formulate questions • set-up the questionnaire • test the survey with some user Survey administration • identify list of respondents • send survey • re-solicit responses, if necessary Collect & Process survey responses • monitor answer collection • export data • process data Interpret & Share survey results • draw insights from result analysis • anonymizing data if needed • select suitable open licenses • openly publish research results (e.g. as research objects) Research question Collect & Process survey results Survey administration Link of the survey sent by email to 120 people hosting photometers. One reminder after a week from the initial sending. 83/120 volunteers answered the survey (69%) 2 Survey design Selection of investigated factors • Reference methodology inspired by the Schwartz Theory of Basic Values1 • 10 motivating factors related to instinsic motivation that may influence CS global motivation (self-direction, stimulation, hedonism, achievement, power, conformity, benevolence, universalism, routine and belongingness) Questions formulation • 2 closed questions for each motivating factor (answers values from 1 to 5) • 1 closed question for global motivation (answers values from 1 to 5) • 1 open question for free text motivation • 10 questions for demographics and data usage Total: 32 questions TESS network initiative aims to collect sky brightness measurements through sensors to fight light pollution Telescope Encoder and Sky Sensor (TESS-W) photometer is a compact and inexpensive device developed under STARS4ALL project by the Universidad Complutense de Madrid As of today, 200+ TESS photometer hosted by 120 people in Asia, Africa, North and South America, Europe and Australia (sensors displayed on this map https://tess.dashboards.stars4all.eu/) Citizen Scientists mainly involved in data collection task. No monetary rewards for participants. Interpret & Share survey results The survey structure, the collected answers and the analysis of correlation are openly available in RDF and CSV formats on Zenodo https://zenodo.org/record/3739058#.XxcK1udS9PY. Reproducibility and Open Science. This survey can be reused to study motivation in other CS communities. Contact us to have support on this! The TESS Network community Demographic In your own word, which is the main motivation why you decided to host a photometer? How much are you motivated in participating to the TESS Network? Global motivation Motivating factors 85% are male, 70% of volunteers are older than 45 years old Which of the following categories identifies you the most? What are you using (or planning to use) the data provided by your photometer for? 75% interested in downloading, exploring or using data collected from all the sensors installed, but only 30% has evidence about data usage by researchers. Learning about the project discoveries has in itself been framed as a reward. Increasing the sharing of the results can be an added value for the community. Factor Mean Answers Correlation with global motivation Questions Self-direction 4,43 0.491*** want to learn interested in topics Benevolence 4,42 0.62*** good thing to do contribute and help the scientific research Universalism 4,33 0.672***


IPM strategies against Drosophila suzukii (IPMDROS) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 130,000 Picture 1 Picture 1 Picture 1 Goals The goal of the project is to participate to the development of IPM programs for the control of D. suzukii , that are of great importance to reduce the huge economic impact that this fly can potentially exert on European agriculture Research consortium ES-INIA; TR-GDAR, AT-AGES; IT-CRA; BE- ILVO Contact information Project coordinator: Ismael Sánchez Ramos ismael@inia.es Key outputs and results The expected results of the project are: • A temperature based model including parameters such as mortality of immature stages, developmental rate of immature stages, reproduction, longevity of adults, life table parameters for the prediction of risk situations, possible new areas of colonization and number of generations per season to be implemented in an IPM approach for the control of D. suzukii. • A basic data survey about the cold tolerance and overwintering strategies of European populations of D. suzukii to determine which European countries are at risk of D. suzukii establishment. • Improved reliable and easy to handle trapping devices for monitoring and population reduction of D. suzukii. • Evaluated selective insecticides with different mode of action (e.g. IGRs) and alternative plant protection products including entomopathogenic microorganisms for the control of D. suzukii to increase the available alternative control methods for IPM programs. • Surveys and protocols for early detection of D. suzukii in non-invaded countries. Objectives Objectives are •To improve of basic knowledge about the biology of the fly, including overwintering behaviour and effect of temperature on development, reproduction and population increase. •To develop of effective trapping systems for population reduction •To evaluate alternative methods for control, such as insect growth regulators and entomopathogenic microorganisms. •To monitor surveys for early detection and development of quarantine measures and effective surveys of goods in global trade among countries 07/2014-12/2016


Zielgruppe Wir schaffen eine bedarfsgerechte Infra- struktur für die Forschungsdaten unserer Communities von der Architektur-, Kunst- und Musik- bis hin zu Theater-, Tanz-, Film- und Medienwissenschaft. Struktur Dienste Ressourcen Helpdesk KONSORTIUM FÜR FORSCHUNGSDATEN ZU MATERIELLEN UND IMMATERIELLEN KULTURGÜTERN NFDI4Culture strukturiert sein Arbeitspro- gramm entlang des Forschungsdatenlebens- zyklus in sechs operative Aufgabenbereiche. Ein siebter umfasst alle Prozesse, die Administration und Kommunikation. Unser übergeordnetes Ziel sind die Registrierung und die Verbesserung bestehender Dienste sowie die Entwicklung neuer Dienste für das Forschungs- datenmanagement. In unserer Knowlege Base stellen wir Handreichungen zur Verfügung, kuratierte Findmittel, Berichte, Videotutorials und daneben auch technische Schnittstellen zu Forschungsdaten. Der NFDI4Culture Helpdesk berät zu allen Fragen rund um das Management von Forschungsdaten in allen Phasen des Daten- lebenszyklus. Spokesperson und Hosting Institution 55131 Mainz Prof. Torsten Schrade Akademie der Wissenschaften und der Literatur | Mainz Geschwister-Scholl-Str. 2 Kontakt Mastodon: https://nfdi.social/@nfdi4culture https://nfdi4culture.de contact@nfdi4culture.de Abb. v.o.: Mittelalterliche Glasmalerei: Jüngstes Gericht, Weltgerichtsfenster im Dom Eichstätt, Andrea Gössel, CC BY-NC 4.0; Illustration des NFDI4Culture Arbeitsprogrammes, Sarah Pittroff, CC BY 4.0; Business boy with rocket, A.J. Rich; AI Human Brain Processor Circuit, 13FTStudio; Vintage styled rotary phone with help sign on a white background, Doomu.


The Impact of Living with Spinal Muscular Atrophy in Malaysia from Patients’ and Caregivers’ Perspectives. Karina Koh1 , Azlina Ahmad Annuar2, Fahisham Taib3, Koh Cha Ling4, Edmund Lim Soon Chin5 , Ch’ng Gaik Siew6 1Clinical Research Centre, Hospital Kuala Lumpur, 2Department of Biomedical Science, Faculty of Medicine, University of Malaya, 3Department of Paediatrics, Hospital Universiti Sains Malaysia, 4HELP University, Kuala Lumpur, 5Persatuan Kebajikan Ceriajaya Kuala Lumpur Dan Selangor (WeCareJourney), 6 Genetics Department, Hospital Pulau Pinang. NMRR-18-3248-42367 Introduction: Spinal Muscular Atrophy (SMA) is a recessively inherited neuromuscular disorder caused by deletions or mutations in the survival motor neuron 1 gene (SMN1). Estimated incidence rate in Malaysia is 1 in 20,000 population with 25-50 babies born annually.¹ The clinical type of SMA is defined by the age of onset and severity of the disease, from type 0 to type 4. 2 Currently, there is no cure for SMA, but disease modifying therapies can delay disease progression. There is a lack of knowledge on SMA amongst the public and even healthcare providers, which may impact the perception of the disease and its proper management. This study aims to explore the impact of SMA on the lives and daily activities of SMA patients and their caregivers. Methods: This was a mixed method cross-sectional study consisting of; Conclusion: This study, to the best of our knowledge represents the first comprehensive study on SMA in South East Asia, highlights a plethora of issues and challenges experienced by PWSMA and their caregivers in Malaysia, from the point of SMA diagnosis and throughout the management of care, in addition to the deep psychosocial impact of living with SMA. Their voices will help to inform stakeholders of areas of improvement needed in clinical practice, the education system and the society at large. Results: A total of 42 individuals participated in the quantitative survey, of whom 13 were persons with spinal muscular atrophy (PWSMA) and 29 were caregivers. After completing the survey, 7 PWSMA and 23 caregivers proceeded with the interview sessions. Table 1 summarizes the sociodemographic and characteristics of the participants. The impact of living with SMA are as shown in Table 2. The findings from the FGD and IDIs are summarized in Table 3. Characteristics PWSMA N = 13(%) Caregivers of PWSMA N = 29(%) Gender Male Female 5(38) 8(62) 11(38) 18(62) Ethnicity Malay Chinese Indian Others 7 (54) 5 (38) 1 (8) 0 22 (76) 5(17) 1 (3) 1 (3) Age (years) 10-19 20-29 30-39 40-49 50 and above 2 (14) 9 (69) 1 (8) 1 (8) 0 - 2 (7) 10 (34) 9 (31) 8 (28) SMA Type Type 1 Type 2 Type 3 0 (0) 9 (69) 4 (31) 8 (28) 11 (38) 10 (34) Table 1: Characteristic of participants Table 2: Impact of living with SMA Physical & psychosocial impact of SMA PWSMA N = 13 (%) Caregivers of PWSMA N = 29 (%) Feel stressed 7 (54) 16 (55) Feel depressed 5 (38) 6 (21) Feel anxious 5 (38) 22 (76) Feel socially isolated 4 (31) 3 (10) Unable to self transfer 7 (54) 17 (59) Unable to turn in bed 5 (38) 11 (38) Unable to manage personal hygiene 4 (31) 15 (52) Unable to attend work/school 4 (31) 8 (28) Limited social activities 4 (31) 6 (21) Unable to feed oneself 3 (23) 5 (17) Discussion: This study has initiated an important step in raising the voices of PWSMA and their families, by highlighting a number of issues and their unmet needs. The journey from diagnosis to managing their daily lives is fraught with frustrations and anxiety similar to the findings of Qian et al. ⁴ The psychosocial impact of SMA also echoes a study conducted in Denmark where all the adult PWSMA lived with anxiety and fear of progressive motor decline.5 Moving forward, there is a need for a multidisciplinary team to provide a holistic care from diagnosis to treatment, rehabilitation, and psychosocial support. Transdisciplinary collaboration and open communication between all the stakeholders of various specialties focusing on


SSHOC social sciences & humanities open cloud “Social Sciences and Humanities Open Cloud”, has received funding from the European Union’s Horizon 2020 project call H2020-INFRAEOSC-04-2018, grant agreement #823782 How does this thematic SSH Marketplace connect to the EOSC? How will the Marketplace advance SSH and cross-disciplinary research? SSHOC social sciences & humanities open cloud A Marketplace for the Social Sciences and Humanities 1. Contextualised solutions Through a process-oriented approach, centred around the research workflows, the SSHOC Marketplace contextualises interrelated datasets, tools, and services with tutorials, links to training material, user stories, showcases, and other relevant information. Interoperability will be achieved via the Data and Metadata Interoperability Hub being developed within SSHOC. Input For: 2. Modelling the EOSC Federating Core SSHOC Marketplace aims to make use of EOSC Federating Core, especially the Federated Identity (AAI) services and the Helpdesk. Views on common themes will also be exchanged and harmonised with other European and international organizations operating in the EOSC. Specific attention will be paid to the OpenAire initiative and its catalogues. Input For: 3. Bridging EOSC and the SSH community Like EOSC itself, the SSHOC Marketplace is being created and shaped by and for the research communities. The participating research infrastructures have defined the state of the art and user requirements through multiple exchanges with the SSH community using Agile and User Centred Design approaches. Input For: Context Related materials such as code or data are linked, providing additional context Support Users have access to appropriate training materials for their use of tools Community With the inclusion of user feedback or ratings, the Marketplace is a “Stack Overflow” for the SSH Gap analysis With all resources gathered in a central repository, it will be easier to identify tools that don’t exist and should be developed to address specific needs Sustainability A focus on curation and information quality, and the creation of a sustainable governance model and user community ensure the durability of the Marketplace over time Serendipity Users find useful information they hadn’t thought to look for! Join our Community K sshopencloud.eu t @SSHOpenCloud l /in/sshopencloud “ The SSHOC Marketplace is the only fully-integrated discovery portal which pools and harmonises the tools and services useful for the SSH research communities, offering a high quality and contextualised answer at every step of the research data life cycle. info@sshopencloud.eu ✉ SSHOC Partners Read the System Specification for the SSH Open Marketplace Timeline January 2019 Launch of the SSHOC project June 2020 1st release of the SSH Marketplace December 2020 2nd Release of the SSH Marketplace December 2021 Final Release of the SSH Marketplace April 2022 End of the project


COAR - Confederation of Open Access Repositories: Reaching out to global interoperability through aligning repository networks Kathleen Shearer, COAR Executive Director, kathleen.shearer@coar-repositories.org Maxie Putlitz, COAR Office, office@coar-repositories.org Katharina Müller, COAR Office, office@coar-repositories.org COAR, the Confederation of Open Access Repositories, is a dynamic association of repository initiatives launched in October 2009, uniting roughly 100 members and partners from 35 countries from throughout Australia, Africa, Asia, Europe, Latin America, and North America. The association aims to enhance greater visibility and application of research outputs through global networks of Open Access digital repositories. Activities of COAR members and partners are undertaken in working and interest groups as well as task forces. Work areas range from repository content, global interoperability, over education and training to monitoring new trends and developments in the open access repository community. This poster will outline COAR’s latest activities in order to inform the broader repository community and promote greater collaboration with others. COAR is an international organization based in Goettingen, Germany. The association acts as forum to learn about new trends; engage with international colleagues in the repository community; and ensure repositories adhere to global best practices and interoperability standards. COAR also actively promotes the role of repositories within the broader scholarly ecosystem and works with other actors to ensure alignment of services and infrastructure globally. Members and partners come together once a year in a general annual meeting to discuss important developments of the association and in the repository community. COAR has undertaken several activities over the last year to foster global repository interoperability through the initiative “Aligning Repository Networks”. In this initiative several major international organizations joined together to underscore their support for immediate open access to research articles and aim for harmonized standards and common vocabularies. A petition has been set up which is still open for endorsements. Moreover in early February 2015 the Interoperability Working Group published the COAR Roadmap: Future Directions for Repository Interoperability. The roadmap identifies important trends and their associated action points for the repository community and will assist COAR in identifying priority areas for our interoperability


HIGH-THROUGHPUT YEAST SCREENING REVEALS A NEW DIMENSION OF INTRACELLULAR PATHOGENESIS. Malene L. Urbanus2, Harley O’Connor Mount1, Eleanor A. Latomanski3, Dylan Valleau4, Frederick P. Roth1,5,6, Hayley J. Newton3, Alexei Savchenko4,7, Alexander W. Ensminger1,2 1. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; 2. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; 3. Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; 4. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada; 5. Lunenfeld‐Tanenbaum Research Institute Mt. Sinai Hospital, Toronto, Ontario, Canada; 6. Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; 7. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. WHAT IS A METAEFFECTOR? USING YEAST TO FIND THEM. WHAT’S NEXT? Metaeffectors directly target other effectors HOST TARGET indirect Effectors target host proteins Legionella direct Effectors are proteins delivered to host cells via dedicated bacterial translocation machineries. The intracellular bacterial pathogen, Legionella pneumophila, uses a Type IV translocation system to deliver over 300 effectors to the eukaryotic host cell (~10% of its proteome). The canonical role of effectors is to modify host targets. Metaeffectors (or effectors of effectors) directly modify other translocated bacterial proteins rather than the host. Yin-Yang effectors behave like canonical effectors, but indirectly interact through counteracting modulation of a shared host target. 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 0 20 40 60 80 100 L. pneumophila infects a broad range of eukaryotic hosts (from protozoa to humans) and modulates conserved eukaryotic pathways. Because they target conserved pathways, 37% of L. pneumophila effectors cause a yeast growth defect of ≥20%) when heterologously expressed. Normalized spot sizes of effector-expressing yeast clones grown at 1,536 spot density. Yin-Yang effectors Query (MATα, URA3) Array (MATa, HIS3) Diploid (MATa/α, HIS3, URA3) x sidD (lpg2465) sidM/drrA (lpg2464) query screen Induce expression. Image diploid spot size: ceg3 (lpg0080) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 lpg0081 legA8/ankX (lpg0695) lem3 (lpg0696) 0 1000 2000 3000 4000 spot size (px), replicate 2 0 1000 2000 3000 4000 spot size (px), replicate 1 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 sdeB (lpg2156) sdjA* (lpg2508) sidJ (lpg2155) sdbB (lpg2482) sdbC (lpg2391) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), array + query spot size (px), single IDTS lpg1148 legC3 (lpg1701) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 ceg6/pkn5 (lpg0208) ravG (lpg0210) ravJ (lpg0944) legL1 (lpg0945) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 legC7/ylfA lpg2298) mavE (lpg2344) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 lem26 (lpg2523) mavL (lpg2526) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 sidM/drrA (lpg2464) sidD (lpg2465) sidL/ceg14 (lpg0437) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 legA11/ankJ (lpg0436) 0 1000 2000 3000 4000 0 1000 2000 3000 4000 spot size (px), replicate 2 spot size (px), replicate 1 sdeC (lpg2153) sdjA* (lpg2508) sidJ (lpg2155) 0 1000 2000 3000 4000 spot size (px), replicate 1 mavQ (lpg


Enabling the research centres of the future - the case of the Platform at the Interface of Science Plataforma de Interface à Ciência (Platform at the Interface of Science) - PIC is a bottom-up Portuguese informal network developed in 2016 by research managers and administrators (RMAs). This community reaches out around 770 RMAs. The added value of PIC in Portugal is based on: • connecting a broad range of professionals in different areas of specialization, such as science communication, data stewards, knowledge transfer valorization, including pre and post- award, • promoting their professionalization, and • working as a partner directly with policymakers and funders in research and development in proposing suggestions focused on the improvement of research systems. Improvement of research systems Community empowerment Broad range of profiles Exchange of best-practices Identification of bottlenecks Policy recommendations The importance of a strong Research Management system Greater awareness of R&I Policies Quality of the scientific production and translation of R&I results Informed decisions and efficient management Improved capacities within the R&I system to conduct open science Consolidation of European Research Area As a community of practice, PIC in the past has developed several initiatives to empower the community, including national events and online sessions of good practices sharing. Its work providing suggestions of improvements to science policy is done in a co-creation exercise with the inputs of the community, using social platforms. PIC organizes regular online meetings to discuss the latest topics on research management and organizes national events focused on the importance and centrality of research management and administration in the ecosystem. Major activities conducted include: - “Cafés Vamos falar de Gestão de Ciência” - Annual events - Recommendations on new national legal frameworks and regulations in Research and Innovation (Lei da Ciência, PL 51/2018; Regulamento do Emprego Científico da FCT) - Suggestions of improvement of specific funding regulations/initiatives Projetos de IC&DT em todos os Domínios Científicos 2017


Elements: Software Infrastructure for Programming and Architectural Exploration of Neuromorphic Computing Systems PI: Naga Kandasamy, Co-PI: Anup Das Award #: 2209745 Computing platforms currently used to run machine-learning tasks have high carbon footprint. Neuromorphic computing systems, which mimic biological neurons and synapses can implement these tasks in a highly energy-efficient fashion. Major challenges for neuromorphic computing lie in its adoption by users and from a system developer's perspective, to cope with faster time-to-market pressure for new neuromorphic chip designs. Our project develops a software infrastructure called NeuroXplorer, which allows for Spiking Neural Networks (SNNs) to be mapped onto neuromorphic hardware in the most efficient way possible. It provides: • Compiler backends to generate executable code for neuromorphic chips from a high-level specification of the machine-learning task. • Mapping and synthesis tools to execute machine-learning tasks on novel neuromorphic architectures built using FPGA. • High-performance software for hardware/software design-space exploration of new neuromorphic architectures. Project Motivation NeuroXplorer Infrastructure • Design optimization engine that can incorporate hardware design metrics such as energy, latency, throughput, and reliability, as well as SNN-oriented metrics such as ISI distortion and spike disorder. • System software stack that facilitates mapping of SNN-based applications to different neuromorphic platforms. • Cycle-accurate model of neuromorphic hardware utilizing a generalized template, which can be configured with hardware- and technology-specific details from manufacturers of neuromorphic systems. • Design-space exploration using data-flow models to represent machine- learning tasks executing on neuromorphic hardware which allows key performance metrics such as accuracy and power consumption cost to be estimated early during the design process. • Analysis of different technological alternatives for neuron and synapse circuits, and impact of scaling on neuromorphic hardware, facilitating optimization of key system-level design metrics. FPGAs can serve as accelerators for SNNs, for rapid prototyping, and as the deployment platform. QUANTISENC, a quantized spike-enabled neural core design software in Verilog, enables design and synthesis of SNNs on FPGAs. SONIC: Software-Designed Hardware Methodology SONIC (SOftware-defined NeuromorphIC) is an open-source software-defined hardware design methodology to make neuromorphic computing more accessible. Enables the user to define and train an SNN model using a high-level language such as Python, generate the corresponding register transfer level (RTL) description of the hardware, and create the hardware-software interface to improve programmability when the RTL is prototyped on FPGA and ASIC. • Neuromorphic hardware is configurable via software. • Modular System Verilog testbench to verify QUANTISENC for different learning tasks and datasets. • SONIC is available at github.com/drexel-DISCO/SONIC.git under the MIT license. Contact Information Naga Kandasamy kandasamy@drexel.edu Anup Das anup.das@drexel.edu QUANTISENC: Modular Neuromorphic Hardware Design We have started to integrate SONIC into existing courses to teach neuromorphic computing. • User specifies values for various hyperparameters in the SNN: number of layers, number of spiking neurons per layer, neuronal weights, and internal parameters of the neuron (resting membrane potential, threshold potential, and refractory period). • QUANTISENC allows setting separate quantization and precision policies for synaptic weights and internal state variables to co-optimize area, power, latency, and throughput to achieve a target performance. • Python script generates configuration file for design synthesis along with testbench to simulate/verify functionality of the FPGA design. • Available at github.com/drexel-DISCO/quantisenc-public.git under


CMBI Introduction The FAIR (Findable, Accessible, Interoperable and Reusable) principles [1] were proposed to guide researchers to describe and share their data to increase data reuse and research reproducibility. Creating FAIR data can be challenging for multi-omics researchers due to a lack of tooling and a diverse landscape of (meta)data standards differing across -omics types. In X-omics [2], we develop a FAIR Data Cube [3] – a set of tools and services that help researchers in different stages of the Research Data Life Cycle including Creation and publish of multi-omics and metadata, Querying multi-omics studies, Analyzing access-protected data. The Implementation and Demonstration of the X-omics FAIR Data Cube XiaoFeng Liao1, Anna Niehues1,2, Martin Brandt3, Tom Ederveen1, Junda Huang1, Purva Kulkarni1,2, Casper de Visser1, Cenna Doornbos1, Joeri van der Velde4, Michael van Vliet5 and Peter-Bram ’t Hoen1 ¹Center for Molecular and Biomolecular Informatics, Radboud UMC, Nijmegen, The Netherlands, ²Translational Metabolic Laboratory, Radboud UMC, Nijmegen, The Netherlands, ³SURF, Amsterdam, The Netherlands, ⁴Genomics Coordination Center and Department of Genetics, University of Groningen and UMCG, The Netherlands, ⁵Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands. Implementation & Demonstration The FAIR Data Cube is being developed in collaboration with the Trusted World of Corona (TWOC) [4] for demonstration. Contact XiaoFeng.Liao@radboudumc.nl Anna.Niehues@radboudumc.nl Peter-Bram.tHoen@radboudumc.nl Acknowledgements NWO, SURF, TWOC. The Netherlands X-omics Initiative is (partially) funded by the Dutch Research Council (NWO), project 184.034.019. no e e ra References: [1]. Wilkinson, M., Dumontier, M., Aalbersberg, I. et al. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data 3, 160018 (2016). [7] https://github.com/Xomics/ISA-ACTION-Template [2]. www.x-omics.nl [8]. https://github.com/ISA-tools/isa-api [3]. https://github.com/Xomics/FAIRDataCube [9]. https://phenopacket-schema.readthedocs.io/en/latest/index.html [4]. https://www.health-holland.com/project/2020/trusted-world-of-corona [10]. https://github.com/Xomics/TWOCdemonstrator/tree/main/tools [5]. Su Y, Chen D, Yuan D, et al. Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19. Cell. 2020;183(6):1479-1495.e20. [11]. https://fdp.combi.umcn.nl [6]. Sansone, SA., Rocca-Serra, P., Field, D. et al. Toward interoperable bioscience data. Nat Genet 44, 121–126 (2012). [12]. https://fdp.cmbi.umcn.nl/blazegraph/


1.Problem Statement and Objectives The introduction of DT and digital technologies in organisations has led to a growing trend of skills gap, hence more effective strategies for TD are needed. Objectives - Explore the strategies for TD and DT in the case organization. - Ascertain elements of Leadership and Culture connected to TD and DT - Establish what general theory and practice implications can be learned. 2. Context Heath services in Scotland. A case of NHS Education for Scotland (NES) Talent Development - Comprehensive, inclusive, personalized for individual employee; - Not limited to specific work-related interventions - Includes other development, training and learning. - Benefits both employees and organisations (Hedayati Mehdiabadi & Li, 2016; Rezaei & Beyerlein, 2018 ) Digital Transformation - We digitise information, - We digitalise processes and roles that make up the operations of a business - We digitally transform the business and its strategy (Bloomberg, 2018) 6. Methods 4. Influencing Factors Organisational culture: - Knowledge transfer is promoted - Effective communication between employees - Good rewards system Leadership behaviours: - More people-oriented than task-orientated - Leaders’ concern for employees - Motivate and encourage staff 5. Conceptual map of Themes, Theory, Objectives, and Intended Contributions 3. Main Concepts - Exploratory - Case Study -Qualitative -Semi Structured Interviews References: 1.Bloomberg, J. (2018). Digitization, digitalization, and digital transformation: confuse them at your peril. Forbes. 2.Hedayati Mehdiabadi, A., & Li, J. (2016). Understanding Talent Development and Implications for Human Resource Development: 15(3), 263-294. https://doi.org/10.1177/1534484316655667 3. Rezaei, F., & Beyerlein, M. (2018). Talent development: a systematic literature review of empirical studies. 42(1/2), 75-90. https://doi.org/10.1108/EJTD-09-2017-0076 How can Talent Development be more effective during Digital Transformation? Stella Alhassan b00278519@studentmail.uws.ac.uk Director of Studies: Prof Stephen Gibb Supervisor: Dr Silvio Hofmann Download Poster


The insect vectors of Xylella fastidiosa (2) Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 127 000 Picture 1 Picture 1 Picture 1 Goals Philaenus spumarius plays an important role in the transmission of X. fastidiosa and understanding the biology and behaviour of vectors is vital in controlling the spread of the disease. The project aims to improve knowledge on vectors and potential vectors of X. fastidiosa within differing habitats and climates Research consortium SASA (GB), AGES(AT), ILVO (BE), MPI (NZ), INIAV (PT), NIB (SI), UCL (BE), ULB (BE), IVIA (ES), INRAT (TN) Contact information Project coordinator: Katherine Lester Katherine.lester@sasa.gov.scot Objectives The main objectives of the project are: •To investigate the biology of vectors (and potential vectors) of X. fastidiosa, including feeding preferences and behaviour •To perform transmission studies to determine the efficiency of vectors to transmit X. fastidiosa •To study vector abundance and movement between crops and wild plants •To Investigate traps or lures for collection of Philaenus spumarius •To assess potential biocontrol agents for vectors such as parasites, fungi 03/2021-02/2023


I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 Experimental Robotic Systems for Design, Development and Testing of Orthopaedic Devices Nicola Sancisi Department of Industrial Engineering University of Bologna 40136 Bologna, Italy nicola.sancisi@unibo.it Michele Conconi Department of Industrial Engineering University of Bologna 40136 Bologna, Italy michele.conconi@unibo.it Vincenzo Parenti-Castelli Department of Industrial Engineering University of Bologna 40136 Bologna, Italy vincenzo.parenti@unibo.it Abstract—The paper presents new robotic systems for test- ing general medical devices. Two applications are presented that show the advantage of experimental tests and articular models in prosthesis optimization and design. Keywords—orthopaedic devices, prostheses, test, robotic rigs I. INTRODUCTION The main objective of orthopaedic devices such as articu- lar prostheses, prosthetic limbs, orthoses and exoskeletons is to replicate or recover the natural behaviour of a joint. This is obtained by a careful design of the mechanical constraints pro- vided by the device, imposing a wanted motion or behaviour of the limb including the device itself. For instance, articular prostheses aim at recovering the joint mobility and stability after substitution of the patient articular surfaces. Thus, pros- thetic components must replicate the natural joint behaviour, reproduce the function of articular structures removed during the implant, and respect the residual structures. To achieve these results, we believe that prosthesis design should be based on a rigorous process combining experi- mental analysis, joint modelling and prototype testing. Exper- imental motion analysis allow definition of the natural joint behaviour at different loading conditions, highlighting the role of each articular structure in constraining the joint motion [1]. Articular models replicate this role in a computational envi- ronment [1,2], where the articular constraints can be substi- tuted by mechanically equivalent counterparts that will con- stitute the basic features of the prosthesis (or the general de- vice). The result of the design process must be built and tested to verify if it satisfies the desired constraints [3,4]. Patient- specific features could be also introduced in the final solution, requiring personalised measures, design and production [4]. The first and the last step of this process consist in the ex- perimental analysis of the joint before and after implant. Be- fore proceeding with clinical studies on patients, these anal- yses can be performed by in-vitro tests on cadaveric speci- mens. Several in-vitro test rigs were proposed, which allow the study of the human joint dynamic behaviour. These de- vices can be divided into two groups: the human joint simula- tors, which aim at reproducing the behaviour of the joint in a physiological way [5], and the robot-based systems [6], which aim at reproducing the loading conditions at the joint by a ro- bot. The main objective of these rigs is to apply given dynamic external loads to the bones, without additional unwanted con- straints. Limitations of most devices currently in use are low flexion ranges, low dynamics and loads, reduced prescribed set of possible tests. The scope of this paper is to describe a family of new test- ing rigs that overcome the present limitations and that are cur- rently used for joint analyses by our group. Two examples and relevant results are included to show successful applications of a “testing and modelling” approach to prosthesis design and optimization. II. TESTING RIGS A. General Feature The testing rigs were designed and built by our labs and show common characteristics. They feature three main parts (Fig. 1, left): a frame (4), a loading system (2, 3, and 11), and a portal (9). The loading system is a six degrees-of-freedom (dof) robot. A first version was a cable-driven robot using six pneumatic actuators, with an inherent force control.


To boost the green transition, the availability of critical raw materials needs to be ensured. However, the battery sector has been experiencing increasing demand for raw materials for years and is vulnerable for supply risks. METALLICO will: • Recover valuable materials from primary and secondary resources • Demonstrate sustainable production and recovery of (critical) battery metals • Assess end-use of the recovered (critical) battery metals • Identify and characterize (critical) battery metals with innovative technologies • Enable social participation, stakeholder engagement and networking @METALLICO_EU @METALLICO Project * metallico@dechema.de https://metallico-project.eu The primary objective of METALLICO is to develop and validate sustainable and socially responsible recovery strategies for (critical) battery metals and their reuse. METALLICO will develop and optimize five innovative processes to recover the valuable materials needed in the battery industry and in other strategic sectors: Li, Co, Cu, Mn, Ni. METALLICO will demonstrate in four different case studies that the (critical) battery metals can be sustainable produced and recovered by upscaling the five METALLICO processes. Objective 5 Processes 4 Case Studies Demonstration of (critical) battery metals recovery from primary and secondary resources through a sustainable processing methodology. Any dissemination of results must indicate that it reflects only the author‘s view and that the Agency and the European Commission not responsible for any use that may be made of the information it contains. Image source: AdobeStock - 339395914, 406891094, 541126912, 566443983 Coordination: IDENER R&D · Duration: 1 Jan. 2023 – 31 Dec. 2026 Total Project Budget: 13.033.408,00 € · EU Contribution: 11.798.783,25 €


c ACKNOWLEDGEMENTS CONCLUSION OBJECTIVES BACKGROUND REFERENCES The aim of this systematic review was to measure the impact of daily oral supplementation of vitamin D3 plus calcium on the incidence of hip fracture in older people. METHODS RESULTS THE IMPACT OF DAILY ORAL SUPPLEMENTATION OF VITAMIN D3 PLUS CALCIUM ON THE INCIDENCE OF HIP FRACTURE IN OLDER PEOPLE : A SYSTEMATIC REVIEW Preethy Manoj1 ,Dr .Rosemarie Derwin 2,Dr. Sherly George3 1 Royal College of Surgeons in Ireland, Dublin 2, 2Lecturer, School of Nursing & Midwifery, RCSI, Dublin 2 3 Lecturer & Programme Director, School of Nursing & Midwifery , RCSI, Dublin 2 Hip fractures reduce the quality of life and increase mortality. Osteoporosis is the biggest cause of fracture in older people (Nowson 2010).. It is estimated that by 2025, there will be approximately 28,000 new fragility fracture cases in Ireland costing €320 million (The Irish Times 2018)..The role of Vitamin D3 and Calcium in bone health is well known. The efficacy of daily oral supplementation of calcium plus vitamin D3 on the incidence of hip fracture and non-vertebral fracture in older men and women with or without risk of fracture remain equivocal. This review aims to fill this gap in the understanding. A systematic review with meta-analysis. was carried out. The databases such as CINAHL, MEDLINE, PubMed, Embase, and Cochrane Library were used to search the key terms along with Wiley Online library, HSE online library and Google Scholar. Also, the reference list of the retrieved articles was scanned to identify more studies. The search was conducted from October 2019- January 2020. The Cochrane risk of bias tool was used to check the quality of the included studies. A meta-analysis using Revman 5.3 was used to analyse the data. You probably won’t have any symptoms in early-stage osteoporosis. Once your bones get weak enough, you might start having back pain from fractured or collapsed vertebrae. You may also start leaning forward in a stooped position and measure an inch or two less than before your bone loss. Figure 1 forest plot on the incidence of hip fracture A total of 12,620 older people, both men and women participated in seven RCTs evaluating the impact of combined daily oral supplementation of cholecalciferol and calcium on the incidence of hip fracture in older adults. This review identified a 25% reduction in hip fracture and a 20% reduction in all non-vertebral fractures among older adults who received Vitamin D3 and Calcium supplementation. Vitamin D3 plus calcium supplementation did not show any remarkable increase in the femoral neck bone mineral density. The subgroup analysis identified that daily oral supplementation of 800 IU of vitamin D3 plus 1200 mg of calcium is more effective in reducing hip fracture compared to 800 IU vitamin D3 plus 1000 mg of calcium. The findings of this review serve as a guideline in practice, education, research, and policy. Nonetheless, there is need for well-structured randomised controlled trials evaluating the effectiveness of Vitamin D3 plus calcium on the incidence of hip fracture and other fractures in older people. Nowson, C.A. (2010) Prevention of fractures in older people with calcium and vitamin D. Nutrients, 2(9), pp.975 The Irish Times. (2018) Retrieved from https://www.irishtimes.com/life-and-style/health-family/fitness/the- osteoporosis-time-bomb-1.3425377 on 30/10/2019. 984. I would like to extend my sincere gratitude to the exceptional Staff in the School of Nursing and Midwifery in the Royal College of Surgeons in Ireland whose lectures, guidance and supervision helped me to complete this project.