STUDY OF PROTON-NUCLEUS INTERACTIONS IN THE DsTau(NA65) EXPERIMENT AT THE CERN-SPS  ABSTRACT: The DsTau (NA65) experiment at CERN was proposed to measure an inclusive differential cross-section of Ds production, and its decay branching ratios in p-A interactions. The DsTau detector is based on the nuclear emulsion technique providing an excellent spatial resolution for detecting short-lived particles like charmed hadrons. The first results of the analysis of the pilot-run data are presented. The accuracy of the proton interaction vertex reconstruction is reported. A high precision in vertex reconstruction allows one to measure the proton interaction length and charged particle multiplicities accurately in a high-track density environment. The measured data have been compared with several Monte Carlo event generators in terms of multiplicity and angular distribution of charged particles. The results presented in this study can be used to validate event generators of p-A interactions. Elena FIRU* on behalf of the DsTau (NA65) Collaboration *Institute of Space Science – subsidiary of INFLPR PHYSICS GOALS STUDY OF TAU NEUTRINOS Tau neutrino is one of the least studied particles • only a few measurements: i. Direct 𝜈𝜏beam: DONUT (DIS) - first direct evidence of tau- neutrino interaction ii. Oscillated 𝜈𝜏: OPERA (DIS), Super-K (QE), IceCube (DIS) • cross section error >50% (DIS) due to systematic uncertainty in 𝜈𝜏production A new precise measurement of the ντ cross section • test lepton universality • new physics effects in ντ CC interactions Future ντ measurements • SHiP: high statistics measurement at the SPS • reduce statistical uncertainty from 33% in DONuT • indirectly FASER DATA PROCESSING full surface scanning is done to accumulate all charged tracks segments by Hyper Track Selector (HTS) • HTS scans emulsion tracks with the speed of 5000 cm2⁄h Preselect events in the precession measurement to search for small angle decay of Ds→𝜏 ALIGMENT AND TRACK RECONSTRUCTION reconstructed visual of a Ds decay candidate alignment algorithm - very precise - sub micron track reconstruction - positions and angular correspondences average efficiency is higher than 95%. proton beam tracks were checked in detail processing in sub-volumes 1.5 cm x 1.5 cm x 30 plates not interacted protons Computing infrastructure protons interacted in the last tungsten yellow line segments show the trajectories of charged particles in the emulsion films June 16-22, 2024 Milan, Italy EXPOSURE AT SPS, CERN DETECTOR ASSEMBLY AT CERN NUCLEAR EMULSIONS FILMS PRODUCTION detector assembly take place at CERN Dark room DEVELOPMENT AT CERN take place at dark room of the CERN Emulsion Facility PRIMARY VERTEX RECONSTRUCTED for estimation of vertex reconstruction efficiency, the true vertex position is compared with the reconstructed Monte Carlo DATA ANALYSIS a sample from 2018 pilot run data is used for proton interaction characterization measurement of interaction length in tungsten in presented Summary: ●DsTau(NA65) experiment aims to study tau neutrino production by Ds decays ●2018 pilot run data sample is analyzed to study proton interactions in tungsten ●proton interaction length in tungsten is measured for the first time, results will be submitted for publication ●data analysis of physics runs data is going on References: 1. Aoki S, Ariga A., Ariga T., all, Development of proton beam irradiation system for the NA65/DsTau experiment, Journal of Instrumentation, Volume 18, October 2023 2. Ariga, A. Status and plans of the DsTau Experiment, SPSC Open session June 2021 3. A. M. Guler, NA65(DsTau): study of tau neutrino production in p-A interactions, PoS TAUP2023 (2024) 157 4. Ariga, A. DsTau status report 2023 (https://cds.cern.ch/record/2868526/files/SPSC-SR-334.pdf) 5. E. Yüksel, NA65/DsTau: Study of Tau Neutrino Production in p-A interactions, 31st International Workshop on Deep Inelastic Scattering, April 2024, Grenoble, France Cross section measureme


Glitch Flow Francesco Sarandrea°*, Lorenzo Asprea°*, Elia Cellini ,Federica Legger°*, Sara Vallero°* * INFN,° Virgo Collaboration, University of Turin A Digital Twin to simulate transient noise in the Virgo interferometer f § §


MATERIALES Y MÉTODOS Las prácticas agroforestales como mecanismo de adaptación al cambio climático Mosquera-Losada MR1*, López-Díaz ML2, Ferreiro-Domínguez N1, Rodríguez-Rigueiro FJ1, Arias Martínez D1, Santiago-Freijanes JJ1, Coello J3, Papadopoulou P4, Rigueiro-Rodríguez A1 1Escola Politécnica Superior. USC. Campus de Lugo. Benigno Ledo s/n. 27002, Lugo, España; 2 Centro Universitario de Plansencia. Universidad de Extremadura. Virgen del Puerto 2, 10600, Plasencia, España; 3Centro Tecnológico Forestal de Cataluña, Ctra. de St. Llorenç de Morunys, Solsona, España; 4Faculty of Agronomy University of Thessaloniki, 54124, Thessaloniki, Greece *mrosa.mosquera.losada@usc.es RESULTADOS (GALICIA) CONCLUSIÓN: Existe una importante variabilidad genética que debe ser evaluada y que permite al agricultor, tras una adecuada selección y uso, una mejor adaptación al cambio climático y por ende incrementar la resiliencia de sus explotaciones. AGRADECIMIENTOS Investigación financiada por el Programa de Desarrollo e Innovación H2020 a la red temática europea Agroforestry Innovation Networks (AFINET, nº727872), el Ministerio de Economía y Competitividad (CTM2016-80176-C2-1-R) con nombre “Sistemas agroforestales para la producción de cereal como estrategia de adaptación y mitigación al cambio climático en el ámbito de la península ibérica” (AGFCLIMA) y la XUNTA DE GALICIA, Consellería de Cultura, Educación e Ordenación Universitaria (“Programa de axudas á etapa posdoutoral DOG nº122, 29/06/2016 p.27443, exp: ED481B 2016/071-0”). Este trabajo se llevó a cabo por la USC para contribuir a los objetivos de la Global Research Alliance sobre gases de efecto invernadero en la agricultura (www.globalresearchalliance.org). La información mostrada no debe ser considerada como que representa el punto de vista de la Alianza en global o sus representantes. - Cataluña - Extremadura - Galicia INTRODUCCIÓN Los eventos extremos asociados al cambio climático pueden causar la destrucción de la cosecha. Los sistemas agroforestales, específicamente los silvoarables, han demostrado ser un sistema de uso sostenible de la tierra que favorece la adaptación al cambio climático. Sin embargo, la sombra generada por el arbolado puede reducir la productividad del cultivo. OBJETIVO Evaluar en tres condiciones climáticas distintas (Extremadura, Galicia y Cataluña) la capacidad de diferentes variedades de cereales a adaptarse a condiciones de sombra. En la fase de invernadero se sembraron diferentes variedades de cereales (diseño de bloques al azar) en condiciones de plena luz y de sombra artificial (30 y 50%) Las variedades mejor adaptadas a las condiciones de sombra en el invernadero se establecieron en el campo bajo especies arbóreas de diferente edad Los resultados se analizaron con ANOVA INVERNADERO - Cebada - Triticale - Trigo Maíz, centeno y trigo CAMPO - Extremadura (Nogal, Encina) - Galicia (Nogal , Castaño) - Cataluña (Nogal) NOGAL CASTAÑO


Tool Studies 2.0 Zum Potenzial von Trans formern für die Erkennung und Klassifikation von Soft ware-Tools in DH-Publikationen VON KNOCHEN 1. Digitale Tools und die Digital Humanities? Software-Tools spielen in den Digital Humani ties eine zentrale Rolle, ja, sind geradezu gen re-prägend für diese Disziplin. Aufbauend auf Vannevar Bushs früher Vorstellung von Maschi nen als “Erweiterungen des menschlichen Geistes” und J. C. R. Lickliders Folgekonzept ein er “Mensch-Computer-Symbiose” ist deren Rolle und ihre erkenntnistheoretischen Implikationen immer wieder diskutiert worden. 2. Forschungsansatz Ziel der Forschung ist die Ana lyse von Toolnennungen in den Digital Humanities und deren Zusammenhänge in der Wis senschaftsdisziplin. RAUMSCHIFFEN* ZU 3. Von Daten zu Trainingsdaten 4. Klassifikationsmodelle 5. Erste Einsätze der Modelle Manuel Burghardt, Nicolas Ruth, Andreas Niekler Computational Humanities Group, Universität Leipzig 3737 englische Veröffentli chungen aus drei DH Jour nals, veröffentlicht zwis chen 1966 und 2020. Durch die Synthese ver schiedener Toolsammlungen (z.B. TaPOR) wird eine manuell gesäuberte Liste von 246 gängigen Tools erzeugt, die möglichst keine ambigen Namen enthält. Mit Hilfe der Liste und einer Wör terbuch-basierten Suche werden Das Labeling teilt sich in zwei Ansätze. Binär: Tool vs. Kein Tool Mehrklassig: Toolober kategorie einer Taxono mie Finale Datensätze Binär 11.211 Negativ- und 7.687 Positivbeispiele Um Korpora nach Toolnennungen durchsuchen zu können, muss ein Klas sifikakationsmodell entwickelt werden. Naive Ansätze erwiesen sich als un tauglich. Das kontextsensitive Potenzial von Transformer-basierten Sprach modellen muss erprobt werden. Sprach modell RoBERTa Fine-tuning binär Fine-tuning mehrklassig 0,99 0,94 - 0,99 F1 F1 Sequenz, Label – Paare erzeugt. Die Sequenzen bestehen aus {15 to kens, tool, 15 tokens} Im Folgenden wurde der initiale Datensatz aus 3737 Publikationen per Sliding Window in 750.210 Sequenzen geteilt und diese mit beiden Modellen klassifi ziert. Bei 1,93% wurde eine Toolnennung erkannt. Mehrklassig no_tool: 11.211 Programming Lan guages/Packages: 2102 Text Analysis Tools: 1325 ... (text analysis, plattforms and communication, program ming languages, ...) {...} Binär Toolnennungen erkennen und Tools extrahieren Erweiterung von TaPOR Mehrklassig 1970 1980 1990 2000 2010 Welche Toolkategorien sind wie dominant im Laufe der Zeit? 2020 1970 1980 1990 2000 2010 2020 text analysis tools network analysis tools visualization tools platforms and communication exhibition, collection & edition plat forms authoring, annotation, editing, pub lishing platforms programming languages Stanley Kubricks 2001: A Space Odyssey behandelt in seiner Passage Dawn of Man auf essayistische Weise die Beziehung zwischen Mensch und Werkzeug. In einer zentralen Sequenz verwandelt sich ein Knochen zu ei nem Raumschiff und visualisiert damit diese Verhätlnis. *


Energetic particles and the solar cycle: Impact of solar magnetic field amplitude and geometry on SEPs and GCRs diffusion coefficient B. Perri1, A. Strugarek2, A. S. Brun2, V. Réville3 and E. Buchlin4 1 Centre for Mathematical Plasma Astrophysics, KU Leuven, Celestijnenlaan 200b-box 2400, B-3001 Leuven, Belgium 2 Université Paris Saclay and Unviersité de Paris, CEA, CNRS, AIM, F-91190 Gif-sur-Yvette, France 3 IRAP, Université de Toulouse III-Paul Sabatier, CNRS, CNES, Toulouse, France 4 Université Paris-Saclay, CNRS, Institut d’astrophysique spatiale, 91405, Orsay, France Abstract • Réville V, Velli M, Panasenco O, Tenerani A, Shi C, et al., 2020, ApJ, 246(2): 24 • Shalchi A, Bieber JW, Matthaeus WH, 2004, ApJ, 604(2): 675-686 • Spruit HC, 1981, vol. 450, Jordan S, (Ed.) NASA Special Publications, pp. 385-413 • Zank GP, Matthaeus WH, Bieber JW, Moraal H, 1998, J. Geophys. Res., 103(A2): 2085 • Bieber JW, Matthaeus WH, Shalchi A, Qin G, 2004, Geophys. Res. Lett., 31(10):L10, 805 • Chhiber R, Subedi P, Usmanov AV, Matthaeus WU, Ruffolo D, Goldstein ML, Parashar TN, 2017, ApJ, 230(2): 21 • Heber B, Potgieter MS, 2006, Space Sci. Rev, 127(1-4): 117 • Jokipii JR, Parker EN, 1970, ApJ, 160:735 • Mignone A, Bodo G, Massaglia S, Matsakos T, Tesileanu O, Zanni C, Ferrari A, 2007, ApJ, 170(1): 228 Get the article here! Hey, that’s me! doi/10.1051/swsc/2020057 SEPs (Solar Energetic Particles) are correlated with the 11-year solar cycle due to their production by flares and interaction with the inner heliosphere, while GCRs (Galactic Cosmic Rays) are anti-correlated with it due to the modulation of the heliospheric magnetic field. The solar magnetic field along the cycle varies in amplitude but also in geometry, causing diffusion of the particles along and across the field lines; the solar wind distribution also evolves, and its turbulence affects particle trajectories. We combine 3D MHD (magnetohydrodynamic) compressible numerical simulations to compute the configuration of the magnetic field and the associated polytropic solar wind up to 1 AU, with analytical prescriptions of the corresponding parallel and perpendicular diffusion coefficients for SEPs and GCRs. First, we analyze separately the impact of the magnetic field amplitude and geometry for a 100 MeV proton. By varying the amplitude, we change the amplitude of the diffusion by the same factor, and the radial gradients by changing the spread of the current sheet. By varying the geometry, we change the latitudinal gradients of diffusion by changing the position of the current sheets. We also vary the energy, and show that the statistical distribution of parallel diffusion is different for SEPs and GCRs. Then, we use realistic solar configurations, showing that diffusion is highly non-axisymmetric due to the configuration of the current sheets, and that the distribution varies a lot with the distance to the Sun, especially at minimum of activity. With this model, we are thus able to study the direct influence of the Sun on Earth spatial environment in terms of energetic particles. Fig. 1: Time evolution of the count rate of >70 MeV protons at Earth (black), by Voyager 1 (red) and Voyager 2 (green) (Heber & Potgieter 2006). We see the anti-correlation with the 22-yr cycle. Modeling the solar wind We solve the ideal MHD equations up to 1 AU using the multi- physics code PLUTO with a polytropic wind model (Mignone +2007, Réville+2015a, Perri+2018). Wind reference case D1 (dipole of low amplitude): Fig. 2: Meridional cut of the wind solution for case D1 (dipole of low amplitude). The colorscale represents the Mach number projected on the normalised magnetic field. The white lines are the poloidal magnetic field lines (Perri+2020). Modeling the cosmic rays diffusion We focus on the diffusivity term in the Fokker-Planck equation for cosmic rays (CRs) transport and implement them in post-processing (Parker 1965, Jokipii & Parker 1970, Zank+1998, Shalchi +2004): We also need to model the w


Closing the feedback loop With the improved calibration of the ALMA observation we are able to trace in the detailed morphology and kinematics of the filaments of cold molecular gas of and the CND in the central regions of NGC 1275. The data clearly show how kpc-sized filaments flow towards the CND and how they are accreting onto the CND, building it up in mass. This on-going formation of the CND is further confirmed by the non-regular kinematics of the outer regions of the CND which suggest that the gas there is not in a kinetically relaxed state due to the arrival of new filaments. This allows us to complete the picture of the gas cycle in NGC 1275. Several authors have suggested that in NGC 1275 we observe a mixture of heating and cooling processes in the gaseous medium driven by the AGN, and how these processes could be connected to AGN fuelling (Salomé et al. 2006; Lim et al.2008; Scharwächter et al. 2013). Multi-phase outflows driven by the jets, cool as they rise, leading to formation of colder gas filaments (Qiu et al. 2020). Earlier studies have proposed these filaments may fall back and accrete onto the CND and eventually fuel the AGN (Salomé et al. 2006; Lim et al 2008), similar as in models of AGN-driven accretion models (Gaspari et al. 2017). This would close the feedback and fuelling loop of the AGN. Our results from ALMA provide the observational evidence that this process is indeed occurring. Molecular gas feeding 3C 84 Past observations with a resolution of about 1 kpc of the cold molecular gas in the regions of NGC 1275 hosting the radio-loud AGN 3C 84, have shown that it is primarily concentrated in three radial filaments aligned in the east-west direction that could be radially in-falling gas and feeding a CND (Lim et al. 2008; Ho et al. 2009). However, the relatively low spatial resolution does not allow to separate these large filaments from the CND and to establish whether the filaments are actually accreting onto the CND. Using the much better resolution of ALMA (∼50 pc), Nagai et al. (2019) were able to identify a rotating CND of cold molecular gas in NGC 1275. However, due to bandpass calibration issues due to the strong flux of 3C 84, their data cube suffers from strong imaging artefacts which prevent investigating the possible connection between the filaments and the CND. Here we present results from re-processing these ALMA observations, using a different bandpass calibration scheme which resulted in much improved image quality (see Fig. 5). This has allowed us to clearly detect, with 50 pc resolution, the detailed distribution and kinematics of the molecular gas in the central kpc region of NGC 1275. The main results are shown in Figs 1, 2 and 3 where we present the integrated line emission and the velocity field of the CO(2-1). They show that the distribution and the kinematics of the molecular gas are much more complex than perceived from the Lim et al. and Ho et al. data. Furthermore, they separate the filaments and the CND for the first time and allow us to study the connection between the CND and the molecular gas in the central regions of NGC 1275, and how the large filaments are feeding the CND. Closing the feedback-feeding loop of the radio galaxy 3C 84 Tom Oosterloo1,2, Raffaella Morganti1,2 & Suma Murthy3 1ASTRON, the Netherlands Institute for Radio Astronomy, Oude Hoogeveensedijk 4, 7991 PD Dwingeloo, The Netherlands. 2Kapteyn Astronomical Institute, University of Groningen, Postbus 800, 9700 AV Groningen, The Netherlands 3Joint Institute for VLBI ERIC, Oude Hoogeveensedijk 4, 7991 PD Dwingeloo, The Netherlands. Gas accretion by a galaxy’s central super massive black hole (SMBH) and the resultant energetic feedback by the accreting active galactic nucleus (AGN) on the gas in and around a galaxy, are two tightly intertwined but competing processes that play a crucial role in the evolution of galaxies. Observations of galaxy clusters have shown how the plasma jets emitted by the AGN heat


. The Formation of Catastrophically Cooling Outflows in Star-forming Regions via Non-equilibrium Radiative Cooling Ashkbiz Danehkar, M. S. Oey, and William J. Gray Department of Astronomy, University of Michigan, 1085 S. University Ave, Ann Arbor, MI 48109, USA Supported by NASA HST-GO-14080.002-A and HST-GO-15088.001-A. E-mail: danehkar@umich.edu ABSTRACT Multiwavelength surveys of star-forming regions suggest the presence of catastrophically cooling outflows. Mechanical feedback from super star clusters in starburst regions can produce cooling galactic-scale outflows, but outflows predicted by the adiabatic models cannot lead to strong cooling seen in several star-forming galaxies such as M82 and NGC 2366. We simulate starburst- driven outflows using the MAIHEM non-equilibrium cooling package built on the hydrodynamics code FLASH to determine the existence domains of catastrophic cooling, in the parameter space of the metallicity, mass-loading, kinetic heating efficiency, and ambient density. Although the metallicity has a major role in cooling, radiative cooling is significantly enhanced by increasing mass- loading and decreasing kinetic heating efficiency. Our results demonstrate the significance of radiative cooling for star-forming regions, where coolants could be responsible for the build-up of cold molecular hydrogen (H2) clumps leading to the star formation. Chevalier R. A. and Clegg A. W. 1985 Natur 317 44 Danehkar A., Oey M. S. and Gray W. J. 2021 ApJ, arXiv:2106.10854 Ferland G. J., Chatzikos M., Guzmán F. et al 2017 RMxAA 53 385 Fryxell B., Olson K., Ricker P. et al 2000 ApJS 131 273 Gray W. J., Oey M. S., Silich S. and Scannapieco E. 2019 ApJ 887 161 Heckman T. M., Armus L. and Miley G. K. 1990 ApJS 74 833 Leitherer C., Ekström S., Meynet G. et al 2014 ApJS 212 14 Oey M. S., Herrera C. N., Silich S. et al 2017 ApJL 849 L1 Oey M. S. and Massey P. 1995 ApJ 452 210 Silich S., Tenorio-Tagle G. and Rodríguez-González A. 2004 ApJ 610 226 Smith L. J., Westmoquette M. S., Gallagher J. S. et al 2006 MNRAS 370 513 Turner J. L., Consiglio S. M., Beck S. C. et al 2017 ApJ 846 73 Weaver R., McCray R., Castor J., Shapiro P. and Moore R. 1977 ApJ 218 377 REFERENCES CONCLUSION INTRODUCTION Starburst-driven galactic-scale outflows usually appear in starburst regions, which are created by stellar winds from OB associations in super star clusters (e.g., Heckman et al. 1990; Oey & Massey 1995). The physical properties of starburst-driven outflows have been modeled using the adiabatic assumptions (Weaver et al. 1977; Chevalier & Clegg 1985). According to Weaver et al. (1977), this type of outflows has four regions: (1) freely expanding wind, (2) hot bubble, (3) shell, and (4) ambient medium (see Fig. 1). The adiabatic solutions of the fluid model obtained by Chevalier & Clegg (1985) indicate that the density and temperature profiles in the freely expanding wind region decline with radius r as see Fig. 1. The semi-analytic radiative solutions studied by Silich et al. (2004) imply that there are departures from the adiabatic solutions (Fig. 1), i.e. catastrophic cooling. Observations of some starburst galaxies such as M82 and NGC 2366 support the presence of catastrophic cooling in some regions (Smith et al. 2006; Oey et al. 2017; Turner et al. 2017). FIG 1. From Left to Right, a schematic view an galactic-scale starburst-driven outflow, temperature and density profiles with 4 different regions refined by Weaver el al. (1997), followed by the analytic adiabatic and radiative solutions from Silich et al. (2004). HYDRODYNAMIC SIMULATIONS We conducted hydrodynamic simulations of starburst-driven outflows generated by feedback from a spherically symmetric super star cluster (SSC) characterized by the cluster radius (Rsc), mass deposition rate (Ṁ), wind terminal velocity (V∞), and stellar ionizing fields described by ionizing luminosity (Lion) and spectral energy distribution (SED) surrounded by ambient medium (density namb and temperature


Function of the C-terminal domain of Hkr1, a signaling mucin of Saccharomyces cerevisiae in the context of bud site selection and resistance to the cell wall integrity disruptor HM-1 killer toxin Toshihiro Kondo, Ukyo Suzuki and Shin Kasahara* Food Microbiology Unit, School of Food & Agricultural Sciences, Miyagi University, Sendai, JAPAN *Correspondence; kasahara@myu.ac.jp 1886B Fig. 1 The killer toxin called HM-1 produced by L. mrakii kills some other yeasts such as S. cerevisiae. See the clear zone around growing L. mrakii. HM-1 is known as a cell wall integrity disruptor for sensitive yeasts, also inhibits cell wall b-glucan synthesis. HM-1 is a relatively small protein, consists of 88 amino acids and is very stable at high temperature (over 100℃), high and low pH (4 to 11). by Ryotaro Ozawa Lindnera mrakii (syn. Williopsis saturnus var. mrakii or Hansenula mrakii) produces a proteinous killer toxin called HM-1 which kills sensitive yeasts including Saccharomyces cerevisiae. HKR1 (Hansenula mrakii killer toxin-resistant gene 1) was originally isolated from the genome of S. cerevisiae as a gene whose overexpression overcame the cytocidal effect of HM-1. The gene product Hkr1 is a large, highly glycosylated mucin-like type I transmembrane protein containing an N- terminal signal peptide sequence, Ser/Thr-rich repetitive sequences and a putative transmembrane domain. Calcium binding EF hand and leucine zipper motives were found in its cytoplasmic tail. It also functions as an osmosensor in the high osmolarity glycerol (HOG) MAP kinase pathway. We previously reported that only the partial sequence of Hkr1 endowed HM-1 resistance to the cells, then first in this study, the minimum sequence of Hkr1 required for HM-1 resistance was determined by serial deletions. Apparently the extracellular HMH (Hkr1-Msb2 Homology) domain in addition to the cytoplasmic tail was indispensable for HM-1 resistance. Also we observed that the cells overexpressing partial HKR1 showed altered budding patterns. The haploid S. cerevisiae cells mainly select bud sites in an axial pattern, but bipolar and randomized patterns were often observed in the presence of HM-1. The mutant cells lacking the cytoplasmic part of Hkr1 showed an aberrant budding pattern, too. It is well studied that a series of BUD gene products, Bud1/Rsr1, Bud2, Bud5 and so forth are required for proper bud-site selection in S. cerevisiae. Since both overexpression and disruption of HKR1 gave rise to abnormal budding patterns, Hkr1 might regulate budding coordinately with those proteins, or possibly interacting with some other factors. Moreover, we found that the budding pattern of haploid S. cerevisiae cells grown under the influence of HM-1 was also affected, suggesting that HM-1 perturbed the bud-site selection process. HM-1 has been studied as a cell wall integrity disruptor and believed to inhibit the synthesis of cell wall polysaccharides, but we now postulate that it may target other cellular events such as bud site selection and cell polarity regulation. Our observations could provide important pieces of information to understand the mechanism of the cytotoxicity of HM-1 and the function of Hkr1, especially its cytoplasmic domain in bud site selection as well as cell wall integrity of S. cerevisiae. vector only overexpression of “A” driven by PGAL1 − ＋ − ＋ − ＋ 100 (%) 50 HM-1 killer toxin carbon source monopolar other (deformed) overexpression of “A” driven by PADH1 1120 SFGYSSSSISSIKLSKETIPASKSVSNTQERITSFTSTLRANSQSEKSEGRNSVGSLQSSHISSNPSLST 1190 NTKVDSKSLSRKVSKTMGENGEETGLTTTKTQYKSSSETSGSYSRSFTKISIGPATTAVQTQASTNSVFT 1260 APALSTYPTTPYPSPNSYAWLPTAIIVESSETGPTTASFNPSITGSLPNAIEPAVAVSEPINHTLITIGF 1330 TAALNYVFLVQNPLSSAQIFNFLPLVLKYPFSNTSSELDNSIGELSTFILSYRSGSSTTTLSPKSISSLS 1400 VVKKKKNQQKKNATKSTEDLHPPQVDTSSIAVKKIVPMVDSSKAYIVSVAEVYFPTEAVTYLQQLILDEN 1470 STLYSNPQTPLRSLAGLIDSGIPLGGLTLYGSGDGGYVPSLTSSSVLDSSKGNSQNIDGTYKYGALDDFI 1540 NSFTDSASAGMYAVKIIIFLIVLTIGVLLWLFVAFFAFRHRNILLKRHPRNCIGKSLNNE


In ALMA cycle 6, our team performed a large survey with ALMA (ALCS; ALMA lensing cluster survey; PI: K. Kohno). [Target: 33 clusters (HFF, CLASH, RELICS), Total area: 133 arcmin2, Depth: ~7µJy (source plane)] We perform multi-component SED analysis, utilizing the UV to millimeter photometries. ・Dust temperature Thanks to the deep ALMA observation, the ALCS sample exhibits a wider range in dust temperatures than conventional SMG samples (ALESS and AS2UDS). ・Dust mass ALCS established a nearly “dust mass selected” sample across z=0.5–6. This trend is the same as previous SMG samples, but ALCS probes the lower dust mass range thanks to the lensing effect. LMA Lensing Cluster Survey: Full SED Analysis of z=0.5-6 Lensed Galaxies Detected by Millimeter Observations A Ryosuke Uematsu (Kyoto Univ.), Yoshihiro Ueda (Kyoto Univ.), Kotaro Kohno (The Univ. of Tokyo), Yoshiki Toba (NAOJ), Satoshi Yamada (RIKEN), Ian Smail (Durham Univ.), Hideki Umehata (Nagoya Univ.), Seiji Fujimoto (The Univ. of Texas), Bunyo Hatsukade (The Univ. of Tokyo), Yiping Ao (Purple Mountain Observatory), Franz E. Bauer (Univ. Catolica), Gabriel Brammer (DAWN), Miroslava Dessauges-Zavadsky (Univ. of Geneva), Daniel Espada (Univ. de Granada), Jean-Baptiste Jolly (MPE), Anton M. Koekemoer (STSI), Vasily Kokorev (Univ. of Groningen), Georgios E. Magdis (DAWN), Masamune Oguri (Chiba Univ.), Fengwu Sun (Univ. of Arizona) Uematsu et al. submitted Sub/millimeter galaxies are a key population for the study of galaxy evolution because the majority of star formation at high redshifts occurred in galaxies deeply embedded in dust. To search for this population, we have performed an extensive survey with ALMA, called the ALMA Lensing Cluster Survey (ALCS). This survey covers 133 arcmin2 area and securely detects 180 sources at z~0.5–6 with a flux limit of ~0.2 mJy at 1.2 mm (Fujimoto et al. 2023). Here we report the results of multi-wavelength spectral energy distribution (SED) analysis of the whole ALCS sample, utilizing the observed-frame UV to millimeter photometry. We find that the majority of the ALCS sources lie on the star-forming main sequence, with a smaller fraction showing intense starburst activities. The ALCS sample contains high infrared-excess sources (IRX=log (Ldust/LUV)>1), including two extremely dust-obscured galaxies (IRX>5). We also confirm that the ALCS sample probes a broader range in lower dust mass than conventional SMG samples in the same redshift range. We identify six heavily obscured AGN candidates that are not detected in the archival Chandra data in addition to the three X-ray AGNs reported by (Uematsu et al. 2023). The inferred AGN luminosity density shows a possible excess at z=2–3 compared with that determined from X-ray surveys below 10 keV. 1. Sub/millimeter Galaxy High-redshift dusty star-forming galaxies (DSFGs) are a key population to elucidate the galaxy evolution, because the majority of star formation at high redshifts occurred in galaxies deeply enshrouded by dust. DSFGs are characterized by the prominent far-infrared (FIR) emission from dust heated by stars. At high redshifts, the peak of the dust emission is shifted to the millimeter band in the observed frame, where the selection function is nearly constant across z=1–8 (cf. negative K-correction). Hence, sub/millimeter observations are a powerful tool to study hight-redshift DSFGs (→ sub/millimeter galaxy [SMG]). 2. ALMA Lensing Cluster Survey Comparison of ALCS and other ALMA surveys 4. Dust properties By the SED analysis, we identify six AGN candidates that are not detected in the archival Chandra X-ray data. → X-ray upper limits indicate that they are heavily obscured (Compton-thick) AGNs. Their inferred AGN luminosity density in high-z ultra-/luminous infrared galaxies (U/LIRGs; ) shows a possible excess at z=2—3 compared with the result of X-ray surveys below 10 keV (Ueda+14). → A significant fraction of AGNs at this epoch may be heavily obscured and missed in previous X-ray


Modeling starspots on low mass star GJ 1243 observed by TESS Kamil Bicz, Robert Falewicz, Małgorzata Pietras Astronomical Institute, University of Wrocław, Kopernika 11, 51-622 Wrocław, Poland Email: bicz@astro.uni.wroc.pl Abstract Quasi-periodic modulations of the stellar light curve may result from dark spots crossing the visible stellar disc. Since the release of the ﬁrst TESS sector the possibility of examining such quasi-periodic modulations by assumed dark spots has increased. Thanks to this observations we tried to detect starspot coverage of low mass stars with visible variability of their luminosity. Using the light curves from TESS satellite and the new, BASSMAN package to ﬁt spot models of different complexities, will constructed starspots distribution on individual stars. These models will then be tested to reveal a connection between the starspots and the stellar ﬂares, in order to provide insight into the overall stellar magnetic ﬁeld. Here we present results of modeling of starspots on GJ 1243 with our new tool and compare the results with the previous reconstructions of the spatial distribution. Introduction GJ 1243 (also known as TIC273589987) is fully convective M4.0V dwarf at a distance 11.95 pc, with mass 0.24 M⊙, radius 0.27 R⊙, effective temperature 3261 K (MAST catalog1) and rotation period equal P = 0.592596 ± 0.00021 day [1]. GJ 1243 also has estimated differential rotation parameter of equal 0.012 ± 0.002 rad/day [1] (for the Sun α⊙= 0.2 rad/day). This star was observed only during two, lasting ∼27 days periods, namely TESS sectors 14 and 15. We selected 33433 individual bright- ness measurements (with 2-minute cadence) acquired over approximately 47 days of observations. Due to very low differential rotation shear and very slow changes of the minimal ﬂux phase mainly in sector 15 (Fig. 1) we estimated spottedness of each sector separately without taking differential rotation into account. Small changes in phase of minimal ﬂux of GJ 1243 are more likely caused by evolution of one of the spots than the differential rotation. There are no signiﬁcant changes in phase of maximal ﬂux value. In our analysis we assumed inclination i = 32◦estimated by analysis of spectral observations of this star at wavelengths from 3600 ˚A to 10000 ˚A and Kepler long cadence data [11]. We estimated the amplitude of GJ 1243 normalized ﬂux as 1.00741 by phasing the light curve from sector 14 and 15 and taking the maximal value of averaged phased data. 1690 1700 1710 1720 1730 TBJD [days] 0.0 0.2 0.4 0.6 0.8 1.0 Phase 1.00 1.01 1.02 1.03 1.04 1.05 1.06 Normalized flux Figure 1: Mapping of relative ﬂux (pixel shade, from dark to light) as a function of rotation phase and time for all TESS data of ﬂux vs. time and phase. Red dots with ﬁtted third degree polynomial represent minimal signal in phases and green dots with ﬁtted linear function represent maximal signal in phase. Methods To model starspots on analysed star we used software BASSMAN (Best rAndom StarSpots Model calculAtioN) written in Python 3, by K. Bicz and designed to model starspots on stellar surface using its observational light curve. BASSMAN recreates light curve of spotted star by ﬁtting spot(s) model to data maximising the log probability of star with spots model and is sampling matched model using Markov chain Monte Carlo by ﬁtting contrasts, sizes, stellar longitudes and latitudes of spot(s). The program uses numerous ready-made software packages to model the spots on the star: starry [4], PyMC3 [7], exoplanet [3], theano [12]. We compare our results with analytical solution for average temperature of the spots on a star with effective temperature Teﬀusing [6]: Tspot = 0.751Teﬀ−3.58 · 10−5T 2 eﬀ+ 808 (1) and to estimate percentage of stellar surface covered by spots we use [5, 10]: Aspot Astar = 100% · ∆F F " 1 − Tspot Teﬀ 4#−1 (2) where (∆F/F) is normalized amplitude of light variations, Tspot is mean temperature of spots esti- mated from equation 1 and T


Unified access to cancer proteogenomics data Caleb M. Lindgren, Hannah Boekweg, David W. Adams, Sadie Tayler, CPTAC Investigators, Samuel H. Payne Department of Biology, Brigham Young University, Provo, UT, USA Abstract We present a new method for data sharing across large collaborations to improve reproducibility and transparency, by creating a Python package that serves as an interface (API) to the multi-omics characterization of tumors from NCI’s CPTAC program. Introduction Cancer data has many audiences, including clinicians, biologists, data scientists and patients. Sharing data and analyses across these diverse audiences is challenging. In particular, we want to simplify the link between data and analysis scripts to enable easier data exploration. We embed NCI’s CPTAC data into a software API. Each tumor type describes samples with clinical, omics, and imaging data. Conclusions The cptac Python package brings cancer data to dispersed collaborative groups. Our package incorporates multiple data sets and lowers the entry barrier, expanding our audience while improving reproducibility and transparency. Acknowledgments: National Cancer Institute (NCI) CPTAC award U24 CA210972. Contact: calebmlindgren@gmail.com; hannahboekweg@gmail.com; sam_payne@byu.edu https://payne.byu.edu github.com/PayneLab @byu_sam Results A Python package, cptac, facilitates access to all CPTAC data. Using the package as the single point of data access unifies and simplifies analysis methods across diverse consortia. Current tumor types include: colon, ovarian, endometrial, renal, breast, lung adeno, glioblastoma and head/neck. Comparing clinical attributes Comparing histology with acetylation Mutation effects on the proteome Comparing multi-omics data Features ●One step installation via pip ●Consistent data and formats across cancers ●Data presented in Pandas dataframes, meaning no need for writing parsers ●API facilitates joining across data types ●Seamlessly works with numeric and graphing libraries (numpy, pandas, matplotlib, seaborn, etc.) ●Versioned data releases ●Package automatically checks that it's up to date, and that the latest version of the data is installed Loading data tables


Problema y preguntas de investigación • La memoria de trabajo (MT) permite el mantenimiento a corto plazo de información relevante para el individuo en situaciones de interferencia y/o procesamiento concurrente (Baddeley, 2012). • Es un importante predictor de la comprensión lectora (CL) durante la niñez, llevando a considerar que las intervenciones que busquen mejorar el funcionamiento de la MT podrían generar mejoras en dicha habilidad (i.e., transferencia lejana) (Peng et al., 2018). • Los estudios que evalúan los efectos de estas intervenciones sobre el desempeño en lectura en niños todavía son escasos y la evidencia no es concluyente (Reina-Reina et al., 2024). Entrenamiento de la memoria de trabajo en niños: efectos sobre la comprensión lectora Metodología Diseño y procedimiento. Experimental con pre-test, post-test y grupo control (GC) activo. Participantes aleatorizados al grupo de entrenamiento (GE; n=26) o GC activo (n=25). Se evaluó su desempeño en CL en la fase pre-test y post-test (inmediatamente finalizada la intervención). La intervención consistió en 8 sesiones de 10 min cada una, dos veces por semana en días no consecutivos. Participantes. Muestra intencional (n=51), desarrollo típico, estudiantes de 2do y 3er grado de primaria en una escuela de gestión privada de Mar del Plata (33 niñas; edad M=7.96, DE=0.50 años). Instrumentos. CL. Prueba Comprensión de textos del Test de Lectura y Escritura en Español LEE (Defior Citoler et al., 2006). Se presentan tres textos breves, seguidos de diversos ítems sobre su contenido. Entrenamiento de MT. Tarea informatizada de entrenamiento de la MT visoespacial para niños (Vernucci et al., 2023, ver Figura 1). Se presentan secuencias de estímulos en una matriz de 4x4 celdas. Se debe recordar cada localización, modificándola en la fase de respuesta, indicando la celda adyacente a la derecha de la ubicación original, manteniendo el orden de presentación. Dificultad adaptativa. Vernucci, S.1,3, Demartini, C.1, Aydmune, Y.1,3, Burin, D.2,3, & Canet Juric, L.1,3 santiagovernucci@conicet.gov.ar (1) Instituto de Psicología Básica, Aplicada y Tecnología (IPSIBAT), (2) Facultad de Psicología (UBA), (3) CONICET. Objetivo Evaluar los efectos de transferencia lejana a corto plazo sobre el desempeño en CL de una intervención sobre MT en niños de edad escolar. Conclusiones e implicancias Se observó un efecto de transferencia lejana a corto plazo: los niños que recibieron el entrenamiento de la MT mejoraron su desempeño en CL en mayor medida que los del GC. Se aporta evidencia preliminar en favor de la posibilidad de mejorar el desempeño en esta habilidad a través del entrenamiento de la MT, aunque debe evaluarse el mantenimiento de este efecto para valorar si el mismo resulta duradero. Durante el primer ciclo de primaria los niños están en pleno desarrollo de sus habilidades de lectura (Peng et al., 2018); una intervención breve enfocada en la capacidad de almacenamiento y procesamiento simultáneo de información en la MT podría resultar de utilidad para favorecer el desarrollo de la CL. Resultados • Se implementó un ANOVA mixto de medidas repetidas y se observó efecto de interacción Grupo × Fase, F(1, 49)= 8.54, p= .005, η2p= 0.15 (ver Figura 2). • Las comparaciones por pares indicaron mejoras de pre- test a post-test tanto del GE como del GC (ambos, p< .001). Las mejoras del GE fueron de una magnitud mayor (d= 1.81) que las del GC (d= 0.85). • En la fase post-test, el GE registró un mejor desempeño que el GC, p= .006, d= 0.80. Figura 1. Tarea de entrenamiento de MT visoespacial. Ejemplo de un ensayo con una amplitud de dos estímulos, incluyendo fase de presentacióny respuesta. Figura 2. Puntuación en la tarea de CL, según grupo y fase. Las barrasindican errorestándar.


Chungnam National UniversityThemeasurementsystemwasconstructedwithaPTOtorquemeter(PTOFlansch,SerialNo.70246,MicroManner,Germany)usingatelemetrymethodtomeasurethetorqueandrotationspeedofthePTOdrivingshaftMETHODSRESULTSDept. of Biosystems Machinery Engineering, Chungnam National Univ. BackgroundObjectiveAgricultural tractorSimulation softwareSeverity Analysis of 75kW Agricultural tractorPTO gear Using a field dataMeasurement systemSafety factor simulationMethodField dataPTOgeardesignforagriculturalapplicationsusestheempiricalmethodbecauseofthewiderangeofloadfluctuationsinagriculturalfieldThePTOgearisanimportantpartoftheagriculturaltractorthattransmitsthepowertovariousimplementsThefielddatameasuredduringtherotarytillagewastransformedintotheequivalenttorqueandequivalentrotationspeedField data during rotary tillage and baler operation was obtained through a sensor attached on the PTO shaftWhen the PTO gear is designed, considering the field operation type and severity is necessaryThe maximum, minimum, and average torque and standard deviation during the rotary tillage are 258.17, 0.01, 100.40, and 47.92 Nm. The rated torque of the 75kW agricultural tractor is 269.87 Nm. In addition, the maximum, minimum, and average rotation speed and standard deviation during the rotary tillage are 2555, 1971, 2372, 123 rpm.ThecontactandbendingsafetyfactorsofthePTOdrivinggearanddrivengearduringbaleroperationaregreaterthanthoseduringtherotarytillageandattheratedtorqueKim, Y.J., Chung, S.O., Park, S.J., Choi, C.H., 2011a. Analysis of power requirement of agriculturaltractor by major field operation. J. Biosyst. Eng. 36 (2), 79–88.Kim, Y.J., Lee, D.H., Chung, S.O., Park, S.J., Choi, C.H., 2011b. Analysis of power requirement ofagricultural tractor during baler operation. J. Biosyst. Eng. 36 (4), 243–251.Lee, D.H., Kim, Y.J., Chung, S.O., Choi, C.H., Lee, K.H., Shin, B.S., 2015. Analysis of the PTO load ofa 75kW agricultural tractor during rotary tillage and baler operation in Korean upland fields.J.Terramech. 60, 75-83.A PTO gear was modeled using Romax_Designerand simulated using real field dataThe contact safety factor of the PTO gear during rotary tillage is 1.32 times greater than that during baler operation, while that at the rated torque is 1.53 times greater. The bending safety factor during rotary tillage is 1.62 times greater than that during baler operation, while that at the rated torque is 2.11 times greaterSimulation conditionEquivalenttorque(Nm)Equivalent speed(rpm)Rotarytillage156.552334Baleroperation115.582367Ratedcondition269.872300Equivalent torque෍෍To calculate the equivalent torque and equivalent rotation, the measured data during rotary tillage were divided into 8 levels considering the maximum torque and minimum torque range. The equivalent torque and equivalent rotation speed during the rotary tillage are 156.55 Nm, 2,334 rpm.PTOgearof75kWagriculturaltractorwassimulatedattheratedtorqueconditionandequivalenttorqueduringtherotarytillageconditionsafetyfactorsofPTOgearwerecomparedunderthetwoconditionswhicharerealtorqueconditionandratertorquecondition


Multimesh / cut FEM simulation of Stokes flow around a propeller. [Johansson, Larson, Logg, 2015] Mesh of the Deathstar generated with FEniCS mshr. Tetrahedral mesh generated from a simple CSG description with FEniCS mshr. History The starting point for the FEniCS Project was the combination of the C++ finite element li- brary DOLFIN and the FIAT Python module for tabulation of finite element basis functions. In 2003, the developers of DOLFIN and FIAT joined forces in the creation of the FEniCS Project, which lead to a rapid development of novel technologies for automated finite element code generation, realized in the FEniCS components FFC, UFL and UFC. In 2011, version 1.0 was released and accompanied by the 700-page FEniCS book - one of Springer’s most downloaded and most cited books in the mathematics category in recent years. The release of 1.0 marked the first stable version of FEniCS and presented to users a well-designed, intui- tive and effective user interface for solution of general nonlinear systems of partial differential equations. Since the release of 1.0, most efforts have been directed towards improving the parallel scaling of FEniCS. With the release of 1.5 in early 2015, FEniCS has matured and of- fers cutting edge parallel performance on a range of hardware. Examples fenicsproject.org Authors: Martin Alnæs, Simula Research Laboratory | Jan Blechta, Charles University in Prague | Patrick Farrell, University of Oxford | Johan Hake, Simula Research Laboratory | Johan Hoffman, KTH | Johan Jansson, KTH | Niclas Jansson, KTH | August Johansson, Simula Research Laboratory | Claes Johnson, KTH | Benjamin Kehlet, Simula Research Laboratory | Robert C. Kirby, Baylor University | Matthew Knepley, University of Chicago | Miroslav Kuchta, University of Oslo | Hans Petter Langtangen, Simula Research Laboratory | Anders Logg, Chalmers University of Technology | Kent-Andre Mardal, University of Oslo and Simula Research Laboratory | Andre Massing, Simula Research Laboratory | Mikael Mortensen, University of Oslo and Simula Research Laboratory | Harish Narayanan, Simula Research Laboratory | Chris Richardson, University of Cambridge | Johannes Ring, Simula Research Laboratory | Marie Rognes, Simula Research Laboratory | Ridgway Scott, University of Chicago | Ola Skavhaug, Simula Research Laboratory | Andy Terrel, University of Chicago | Garth N. Wells, University of Cambridge | Kristian Ølgaard, Aalborg University | References: R. C. Kirby. Algorithm 839: FIAT, a new paradigm for computing finite element basis functions, ACM Transactions on Mathematical Software (2004). R. C. Kirby and A. Logg. A compiler for variational forms, ACM Transactions on Mathematical Software (2006). M. S. Alnæs, A. Logg, K.-A. Mardal, O. Skavhaug and H. P. Langtangen. Unified framework for finite element assembly, International Journal of Computational Science and Engineering (2009). A. Logg and G. N. Wells. DOLFIN: Automated finite element computing, ACM Transactions on Mathematical Software (2010). K. B. Ølgaard and G. N. Wells. Optimisations for quadrature representations of finite element tensors through automated code generation, ACM Transactions on Mathematical Software (2010). A. Logg, K.-A. Mardal, G. N. Wells et al. Automated Solution of Differential Equations by the Finite Element Method, Springer (2012). M. S. Alnæs, A. Logg, K. B. Ølgaard, M. E. Rognes, G. N. Wells. Unified Form Language: A domain-specific language for weak formulations of partial differential equations, ACM Transactions on Mathematical Software (2014). Acknowledgement: We gratefully acknowledge the following grants that have supported the development of FEniCS: Center of Excellence grant awarded to the Center for Biomedical Computing at Simula Research Laboratory by the Research Council of Norway, grant no. 179578/F30. Patient-Specific Mathematical Modeling with Applications to Clinical Medicine: Stroke and Syringomyelia, Research Council of Norway, grant no. 209951.


POLIX – The Thomson scattering X-ray polarimeter Hemanth Manikantan*, Biswajit Paul, Rishin Puthiya Veetil, Vikram Rana, Gopala Krishna M R, Rajagopala G., Sandhya, Mamatha T S, Dhi- raj K Dedhia, Nirmal Iyer, Sujay Mate, Krishnamurthy S, Irshad Md, Pooja Verma, Harikrishna Sahu, Ketan Rikame, Shirisha Vissom, Meena G, Varun Bahal and Shreenandini Anand Raman Research Institute, Sadashivanagar, Bangalore, Karnataka 560080, India U R Rao Satellite Centre, Vimanapura, Bengaluru, Karnataka 560017, India hemanthm@rri.res.in 1. Introduction POLIX is the primary scientific payload on the upcoming Indian X-ray astronomy mission XPoSat. POLIX is a Thomson scattering X-ray polarimeter working in the 8-30 keV energy band designed to study the polarised X-ray emission from various celestial X-ray sources. Being a dedicated X-ray polarization mission in this unexplored energy band, POLIX is poised to give us glimpses of a new frontier in high-energy astrophysics and allow in-depth investigations of the astrophysical processes in neutron stars and black hole sources. In this poster, we intend to brief the principle of operation and instrument configuration. Tests and calibration of the position-sensitive X-ray proportional counters are also described, along with some key scientific prospects of POLIX. 2. The principle of operation Thomson scattering is the dominant scatter- ing mechanism in the 10-30 keV energy band. The electron scattering cross-section for incom- ing polarized photons is anisotropic in the plane normal to the incoming radiation. POLIX al- lows the source photons to scatter from a pure Beryllium scatterer block, and four surrounding X-ray proportional counters detect the scattered X-rays. The satellite spins at 0.2 rpm along the viewing axis of the POLIX to reduce systematic errors from different detectors. The azimuthal variation of scattered X-ray flux signifies the lin- ear polarization direction. 3.Mechanical configuration A collimator restricts the FOV, and a Beryllium scatterer is placed below the collimator. Multi- wire proportional counters with wires oriented vertically to the scatter plane are employed to detect the scattered photons in POLIX [1]. Each proportional counter has a wire frame, accom- modating 12 anode cells grouped into 2 different detector channels of 6 cells each. The housing is filled with 800 Torr of a gas mixture containing 90 % Xe, 9 %Ar, and 1 % Methane. The My- lar window opening towards the scatterer-side allows X-rays to pass into the detectors and sup- ports the gas pressure. Identification of the cell in which scattered X-ray is incident facilitates determining the azimuthal distribution of scat- tered X-ray photons. 5. Charge division Identifying the anode cell on which the X-ray is detected is the key to finding polarization di- rection. Six high resistance Nichrome wires in a proportional counter are connected in series, making one channel. The method of charge di- vision is utilized to identify the cell in which the X-ray is absorbed. 4. Wireframe High resistivity Nichrome wires having thickness of 25 µm surrounded by cathode layer consti- tutes an anode cell. 12 main anode cells of di- mensions 3 × 3 × 30 cm surrounded by 30 veto cells having dimensions 1.5 × 1.5 × 30 cm are present. High DC voltage is applied as bias to the wires. The primary electrons deposited by an incident photon are accelerated to the anode wire leading to avalanche and the resultant de- posited charge is detected at both ends of the channel. 6. Specifications Parameter Description Photon collection area 640 cm2 Energy range 8-30 keV Field of view 3◦× 3◦ Modulation factor 40% 7. Spectral calibration 55Fe and 109Cd radioactive sources, having an emission complex at 6 keV and a line at 22.1 keV, respectively, are used for the position and spectral calibration of the proportional counters. X-rays are shined at three different locations on top of each wire. The histograms of the ratio of pulse heights (Ratio hist


a) b) Methods & Materials Abstract Current literature measurements of dielectric constants of nanoparticles reveal contradictory results for nanoparticles with a size smaller than 100 nm depending on the measurement method used [1-3]. In [3] an increasing dielectric constant up to a factor of 3 for decreasing size of the nanoparticles is reported. In [2] the dielectric constant stays constant as a function of particles size. In this work a measurement method is developed eliminating the influence of the topography and of the effective area of the tip-sample capacitor. Experiment Parameters Height above particle (z) is 20 nm to 40 nm CoCr coated AFM-Probes used: SSS-MFMR from Nanoworld (𝑟𝑇𝑖𝑝= 15 𝑛𝑚) MFM_HC from NTM-DT (𝑟𝑇𝑖𝑝= 40 𝑛𝑚) DC-Voltage applied to the tip (𝑉𝐷𝐶) is varied from -4 V to 4 V PS-NP provided by Alpha Nanotech Inc. and Fraunhofer IMM [4] ranging from 27 nm to 122 nm in diameter PMMA-NP provided by Fraunhofer IMM [4] ranging from 70 nm to 300 nm in diameter NPs diluted in water are drop casted onto p-Si dies Measurement data is fitted using MATLAB Results Conclusion & Outlook A measurement method is developed which suppresses topographic crosstalk and which is independent of the effective area of the tip-sample capacitor. Dielectric constant of PS-NP and PMMA-NP is observed to be constant as a function particle size. With the knowledge of the dielectric constant of nanoparticles it is now possible to create and validate methods for data fusion of EFM and AFM to determine the dielectric constant in lift mode measurements as well. Literature [1]M. Fuhrmann, A. Musyanovych, R. Thoelen, and H. Moebius, "Determination of the dielectric constant of non-planar nanostructures and single nanoparticles by electrostatic force microscopy," Journal of Physics Communications, vol. 6, no. 12, 2022 [2]L. Fumagalli, D. Esteban-Ferrer, A. Cuervo, J. L. Carrascosa, and G. Gomila, "Label-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces," Nat Mater, vol. 11, no. 9, pp. 808-16, Sep 2012 [3]M. Descoteaux, J. P. Sunnerberg, and C. Staii, "Quantitative characterization of dielectric properties of nanoparticles using electrostatic force microscopy," AIP Advances, vol. 10, no. 11, 2020 [4] A. Musyanovych, J. Dausend, M. Dass, P. Walther, V. Mailänder, K. Landfester (2011): Criteria impacting the cellular uptake of nanoparticles: A study emphasizing polymer type and surfactant effects, Acta Biomaterialia, Volume 7, Issue 12 Figure1: Capacitor model using linear mode Figure 3: Phase shift as a function of DC-Tip-Voltage (blue) and fitted model (red) Figure 4: Dielectric constant as a function of particle size 𝐴𝑒𝑓𝑓,𝑒𝑥𝑝= 𝜋 2 3 𝑤ℎ 2 Δφ = − 𝑄 𝑘𝜀0(𝑉𝐷𝐶−𝑉𝐶𝑃𝐷)2 𝐴𝑒𝑓𝑓,𝑒𝑥𝑝 𝑧+ 𝑑 𝜀𝑃 3 − 𝐴𝑒𝑓𝑓,𝑒𝑥𝑝 𝑧+𝑑3 (1) Influence of particle size of polymer nanoparticles on the static dielectric constant Lukas Lehnert1, Benjamin Baumann1, Marc Fuhrmann1, Anna Musyanovych2, Ronald Thoelen3, Hildegard Möbius1 1Department of Computer Sciences and Microsystem Technology, University of Applied Sciences, Zweibrücken, Germany, 2Chemistry Division, Fraunhofer IMM, Carl-Zeiss-Str. 18-20, 55129 Mainz, Germany 3Institute for Materials Research, Hasselt University, Martelarenlaan 42, 3500 Hasselt, Belgium E-Mail: lukas.lehnert@hs-kl.de Probe is kept at a constant height (Linear Mode) to eliminate topographic crosstalk [1] Tip-surface capacitor is assumed to be a plate capacitor with an effective area depending on the FWHM of the topography scan across the particle Change of dielectric constant results in phase shift change (1) used to model phase shift Figure 2: 116 nm PS-NP: a)Topography, b) Phase shift Si NP 𝐴𝑒𝑓𝑓,𝑧+𝑑 𝑧 𝑑 𝐴𝑒𝑓𝑓,𝑧+𝑑 𝑧 𝑑 𝐶1 𝐶2 𝐶0


Martina Boscolo*(1, 3), Gabriel O Paz*(1) y Andrea P Goldin(1, 2) (1) Laboratorio de Neurociencia, Universidad Torcuato Di Tella. (2) Consejo Nacional de Investigaciones Científicas y Tecnológicas, Ministerio de Ciencia, Tecnología e Innovación, Argentina. (3) martiboscolo@gmail.com * Igual contribución Proximidad: es la similitud entre las habilidades utilizadas en el entrenamiento con videojuegos y el aspecto al cual se generalizan. - Muy cercana: e.g. cuando se modifica el rendimiento de un jugador en el mismo videojuego. - Cercana: e.g. mejoras visuoespaciales luego de jugar a un videojuego de disparos. - Distante/Lejana: e.g. cuando el entrenamiento afecta el rendimiento académico. Temporalidad: considera la persistencia del aprendizaje. - Corto plazo: hasta 14 días. - Mediano plazo: entre 15 y 59 días. - Largo plazo: a partir de dos meses. Videojuegos con evidencia de entrenamiento vs. más populares. La edad media de los participantes fue de 11,3 años (SD = 3,8). En promedio, el porcentaje de participantes de género femenino fue de 43% (SD = 16,1). No hubo estudios en esta revisión hechos en muestras 100% compuestas por mujeres. El número máximo de mujeres fue de 67%. Figuras (1) País de origen de los participantes (2) Género de los videojuegos estudiados (categorías no exclusivas) (3) Rango etario de los participantes en cada artículo. ●Funciones Ejecutivas (FE) ●Conductas de toma de riesgo, agresivas, impulsivas y delictivas ●Atención y habilidades visuoespaciales ●Alfabetización y lectoescritura ●Pensamiento matemático ●Empatía, conductas prosociales, teoría de la mente Referencias 1. Foley, L., & Maddison, R. (2010). Use of active video games to increase physical activity in children: a (virtual) reality? Pediatric exercise science, 22(1), 7-20. / 2. Rideout, V. J., Foehr, U. G., & Roberts, D. F. (2010). Generation M2: Media in the lives of 8-to 18-year-olds. Henry J. Kaiser Family Foundation. / 3. Bavelier, D., Green, C. S., Han, D. H., Renshaw, P. F., Merzenich, M. M., & Gentile, D. A. (2011). Brains on video games. Nature Reviews Neuroscience, 12(12), 763-768. / 4. Choi, E., Shin, S. H., Ryu, J. K., Jung, K. I., Kim, S. Y., & Park, M. H. (2020). Commercial video games and cognitive functions: video game genres and modulating factors of cognitive enhancement. Behavioral and Brain Functions, 16(1), 2. / 5. Granic, I., Lobel, A., & Engels, R. C. (2014). The benefits of playing video games. American Psychologist, 69(1), 66. / 6. Green, C. S., & Seitz, A. R. (2015). The impacts of video games on cognition (and how the government can guide the industry). Policy Insights from the Behavioral and Brain Sciences, 2(1), 101-110. / 7. Vogel Ciernia, A., Laufer, B. I., Dunaway, K. W., Mordaunt, C. E., Coulson, R. L., Totah, T. S., ... & Yasui, D. H. (2018). Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics, 13(3), 318-330. / 8. Pronk, N. P. (2021). Neuroplasticity and the role of exercise and diet on cognition. / 9. Diamond, A. (2013). Annual review of psychology, 64, 135-168. / 10. Vladisauskas, M., Belloli, L., Miguel, M., Cabral, D., Nin, V., Shalom, D., Fernández-Slezak, D., Goldin, A. (2021). Measuring Executive Functions with a computerized software: results for unsupervised interventions”. Article in preparation. / 11. Nation, M., Crusto, C., Wandersman, A., Kumpfer, K. L., Seybolt, D., Morrissey-Kane, E., & Davino, K. (2003). What works in prevention: Principles of effective prevention programs. American psychologist, 58(6-7), 449. / 12. Jaeggi, S. M., Buschkuehl, M., Jonides, J., & Shah, P. (2011). Short-and long-term benefits of cognitive training. Proceedings of the National Academy of Sciences, 108(25), 10081-10086 / 13. Wang, X., & Covey, T. J. (2020). Neurophysiological indices of the transfer of cognitive training gains to untrained tasks. Neurobiology of learning and memory, 171, 107205. / 14. The NPD Group (2020). Best Selling Video Games. / 15.


Acknowledgements National Center for Combustion Research and Development, IIT Madras is funded by Department of Science and Technology, Govt. of India Objectives • To study the kinetic modeling for efficient design of thermochemical process for e-waste pyrolysis. • To understand the pyrolysate composition obtained from pyrolysis of e- waste under fast pyrolysis conditions. Conclusions UNRAVELLING THE PYROLYSIS KINETICS AND PRODUCT FORMATION FROM ELECTRONIC WASTE J.V. Jayarama Krishna, Suyash S. Damir, and Dr. R. Vinu Department of Chemical Engineering and National Center for Combustion Research and Development, Indian Institute of Technology Madras, Chennai – 600036, India Email:jayaramjv17@gmail.com Results and Discussions • The apparent activation energies calculated using KAS, FWO, and Vyazokin methods behave similarly with conversion and portray the existence of a complex multi-step reaction regime. The accuracy of the kinetic parameters was improved using DAEM. The quality of the fits obtained using DAEM is greater than 92% and 96% for DTG and conversion plots respectively. • The choice of five, six, and two Gaussians were made to describe pyrolysis behaviour of PCB, PCB : KB (1 : 1 wt./wt.), and KB respectively. • The mean activation energy and pre-exponential factor for PCB, PCB : KB (1 : 1 wt./wt.), and KB are in the range of 129-197, 131-202, 127-208 kJ mol-1 and 107-1012, 109-1013, 108-1013 s-1 respectively. Figure 6. Experimental and predicted DTG curves at 10 oC min-1 for (a) PCB, (b) PCB : KB (1 : 1 wt./wt.), and (c) KB samples. Experimental and fitted DTG curves at 20 oC min-1 for (d) PCB, (e) PCB : KB (1 : 1 wt./wt.), and (f) KB samples. Feedstock Characterization Table 1. Ultimate and Proximate analysis of E-waste 100 200 300 400 500 600 700 800 900 0.000 0.002 0.004 0.006 0.008 0.010 100 200 300 400 500 600 700 800 900 0.000 0.002 0.004 0.006 0.008 0.010 100 200 300 400 500 600 700 800 900 0.000 0.002 0.004 0.006 0.008 0.010 0.012 0.014 100 200 300 400 500 600 700 800 900 0.000 0.002 0.004 0.006 0.008 0.010 0.012 100 200 300 400 500 600 700 800 900 0.000 0.005 0.010 0.015 0.020 100 200 300 400 500 600 700 800 900 0.000 0.005 0.010 0.015 0.020 FitDTG=96.5% (a) Expt Model Peak1 Peak2 Temperature ( oC) d/dT (1/K) d/dT (1/K) d/dT (1/K) FitDTG=96% (b) Expt Model Peak1 Peak2 Peak3 Peak4 Peak5 FitDTG=97.6% (c) FitDTG=97.5% (e) (d) Expt Model Peak1 Peak2 Peak3 Peak4 Peak5 Peak6 Expt Model Peak1 Peak2 Peak3 Peak4 Peak5 Expt Model Peak1 Peak2 Peak3 Peak4 Peak5 Peak6 FitDTG=96.8% Temperature ( oC) FitDTG=96.5% (f) Expt Model Peak1 Peak2 100 120 140 160 180 200 220 240 0.00 0.02 0.04 0.06 0.08 0.10 0.12 100 120 140 160 180 200 220 240 0.00 0.02 0.04 0.06 0.08 0.10 0.12 0.14 100 120 140 160 180 200 220 240 0.00 0.05 0.10 0.15 0.20 0.25 0.30 197 kJ mol -1 190 kJ mol -1 180 kJ mol -1 168.5 kJ mol -1 Peak1 Peak2 Peak3 Peak4 Peak5 PeakSum Activation Energy (kJ mol -1) (a) 129 kJ mol -1 202 kJ mol -1 131 kJ mol -1 199 kJ mol -1 195 kJ mol -1 178.5 kJ mol -1 168.5 kJ mol -1 (b) Gaussian distribution function, f(E) (mol kJ -1) Peak1 Peak2 Peak3 Peak4 Peak5 Peak6 PeakSum 128 kJ mol -1 207 kJ mol -1 (c) Peak1 Peak2 PeakSum Aliphatic HC Aromatic HC N-Aromatic HC O-Aromatic HC Other Oxygenates Halogened compounds -30 -20 -10 0 10 20 0 10 20 30 40 50 60 (b) (a) Sd(%) Selectivity (%) PCB : KB 1 : 0 PCB : KB 3 : 1 PCB : KB 1 : 1 PCB : KB 1 : 3 PCB : KB 0 : 1 PCB : KB 1 : 3 PCB : KB 1 : 1 PCB : KB 3 : 1 0 5 10 15 20 25 30 35 40 0 1 2 3 4 0 5 10 15 20 0 5 10 15 20 0 5 10 15 20 0 5 10 15 20 C6H10O5 C18H20N2 C30H50 C15H16O2 C16H32O2 OP(OC6H5)3 C6H5OH (e) Retention Time(min) C12H13N C9H10 C10H11N C30H50 C8H8 C12H13N C9H10 C14H18O5 C14H18O5 C10H11N C13H12N2 C13H12N2 C8H8 (d) (c) Intensity(x10 7 ion count) C12H13N C9H10 C14H18O5 C14H18O5 C12H14 C30H50 C30H50 C14H18O5 C10H11N C13H12N2 C8H8 (b) C12H13N C9H10 C14H18O5 C12H14 C30H50 C14H18O5 C10H11N C13H12N2 (a) C8H8 100 200 300 400 500 600 700 800 900 0.0 0.2 0.4 0.6 0.8 1.0 100 200 300 400 50


BASAL ANGIOSPERMS MONOCOTS EUDICOTS FLC VRN1 VRN2 FLOWERING FLOWERING FLOWERING FLOWERING FLOWERING BTC1 BBX19 FT1 FT2 AcFT2 FLC-independent THE MEMORY OF WINTER IN DIFFERENT PLANT GROUPS BOUCHÉ, WOODS, & AMASINO (2016) - PLANT PHYSIOLOGY POALES ASPARAGALES FABALES CARYIOPHYLLALES BRASSICALES H. vulgare (barley) T. aestivum (wheat) B. distachyon M. truncatula A. thaliana A. alpina C. flexuosa B. vulgaris (beets) A. cepa (onion) DISTINCT PLANT GROUPS EVOLVED DIFFERENT VERNALIZATION SYSTEMS. IN PERENNIALS, FORGETTING WINTER IS IMPORTANT TO SET THE LIFE BEHAVIOR. Find out more at http://dx.doi.org/10.1104/pp.16.01322


Evento Pró Cátedra UNESCO em Economia Criativa e Políticas Públicas O Departamento de Administração e Contabilidade por meio dos grupos de pesquisa - Gestão e Desenvolvimento de Territórios Criativos (GDTEC) e Grupo de Estudos e Pesquisas em Organizações, Sustentabilidade e Tecnologia (GEPOST), estão organizando o evento presencial: Pró Cátedra UNESCO em Economia Criativa e Políticas Públicas Dia: 17/05/2022 (terça-feira) Local: Novo Auditório do CCH I – Anexo do Prédio dos Departamentos de Administração, Contabilidade e Economia Programação: PAINEL 1 NACIONAL - POLÍTICAS, SUSTENTABILIDADE E TURISMO ALTERNATIVO (JUSTO E CRIATIVO) Horário: 14h às 15h45 Coordenadora: Profa. Débora Schneider (UFFS) Apresentadora: Profa. Maria de Fátima Nóbrega (UFCG) - Políticas e Sustentabilidade: hoje... e amanhã? Apresentador: Prof. Layon Cezar (UFV) - Comercio Justo e potenciais diálogos com a economia criativa e turismo Debatedor: Prof. Marcos Knupp (UFOP) PAINEL 2 REGIONAL - AGENDAS, DESENVOLVIMENTO TERRITORIAL E DISTRITOS CRIATIVOS Horário: 16h às 17h45 Coordenadora - Profa. Carolina Lescura (UFOP) Apresentador 1 - Prof. Magnus Emmendoerfer (UFV) - Conectando Agenda Globais com desenvolvimento local - o lugar dos distritos criativos


1. Adolescents are disempowered when it comes to their own mental wellbeing. Out- group experts construct finished interventions and treat adolescents only as recipients. How- ever, adolescents would be useful designers and co-creators of their own interventions. 2. Activities to improve mental wellbeing are presented predominantly language-based and lack customizability. Individual preferences and accessibility are rarely taken into account. How- ever, adolescents are highly heterogeneous, and intervention delivery needs to reflect that. During this 3-year project, a technological toolkit will be developed. With it, adolescents between the age of 14 and 18 will be able to construct applications, which will help them to improve their own mental health and wellbe- ing. They will be able to choose and customize components based on evidence-based posi- tive psychology interventions. Additionally, this toolkit will be geared towards accessibility, with emphasis on non-language based approaches. On completion, the toolkit will be field-tested with diverse Austrian youth. Developing an inclusive technological toolkit to support prevention approaches Supervisors Geraldine Fitzpatrick, Technische Universität Wien Stephen Brewster, University of Glasgow Background Summary Secondments Planned contributions Project plan Context analysis to understand how to use diverse, multimodal technology to support inclusiveness Set of proof-of-concepts interpreting ex- isting preventive approaches into non-lan- guage based mechanisms Ready-to-deploy toolkit, allowing adoles- cents to construct their own applications to support mental health and wellbeing Refined concepts and exploration of the design space, including first prototypes, of inclusive technology to support wellbeing Large-scale study with diverse Austrian youth into how engaging, fun, and poten- tially helpful the toolkit is » Sin & Lyubomirsky (2009) reviewed 51 positive psychology intervention studies with overall 4,266 participants and found significant impact on well- being; a suitable format of the intervention was found important for effec- tiveness. » Spijkerman, Pots & Bohlmeijer (2016) reviewed 15 randomised control trials, specifically for the effectiveness of online mindfulness-based interven- tions and conclude a significant effect on mental health. » Hollis et al. (2017) were able to identify 147 existing digital health inter- ventions, which primarily used computer, smartphones, internet and text messages as delivery mechanisms. » Silverstone et al. (2016) conclude a review of existing mental health tech- nologies by recommending a stronger use of multimodal solutions. » Clarke, Kuosmanen & Barry (2015) conclude a review of existing mental health technologies by pointing out the effectiveness of specifically mod- ule-based interventions for promotion of mental health. » Aye mind (n.d.) offers a toolkit to facilitate learning about mental health technology for young people. » Almirall & Chronis-Tuscano (2016) emphasize the necessity of adaptive in- terventions in support of child and adolescent mental health, because needs and preferences change over time. » Taylor, Leslie, Grampian & Boddie (2017) point towards high potential of wellbeing promoting technology for adolescents. » What types of barriers prevent adolescents from accessing existing interventions? » How can diverse technological modalities be used to support prevention approaches in an inclusive way? » What are common characteristics and com- ponents of existing preventive approaches and how can they be mapped onto a de- sign space? » What would be candidate technologies to realize the toolkit with? » What tools should the toolkit consist of? » What are the particular needs of different audiences of the toolkit? » How to make the toolkit fun and engaging for adolescents? Toni Michel, M.Eng. Mobile: +49 177 3075 023 Mail: toni.michel@tuwien.ac.at Twitter: @T__Michel Almirall, D., & Chronis-Tuscano, A. (2016). Ada


Big Data Contrast Mining for Genetic Distinctions between Disease Subtypes Matt Spencer and Chi-Ren Shyu – University of Missouri Informatics Institute Manhattan Plot by Ikram, M. K., et al. (2010). Complex Disease Etiology Genome-Wide Association Studies find genetic loci (SNPs) that are enriched in a disease-affected population. However, the traditional GWAS approach is not suitable for complex diseases. This is due to the addition of two major challenges when searching for the genetic etiology of a complex disease: We are specifically interested in autism, which may involve a combination of these attributes. We need a way to examine associations between diseases and multiple genes, and to identify genetic differences between subgroups of the affected population. Etiology The cause of a disease or abnormal condition Complex Disease A disease or disorder which cannot be attributed to a single gene • Interactions among genes – e.g. two genes both have to be mutated in order to cause the disease • Multiple causes of the disease – e.g. two genes both cause disease regardless of the state of the other GWAS Associated Genome Regions Frequent Pattern Mining In this research, the items are SNPs within the genomes of autistic individuals. The resulting combinations indicate groups of rare-form SNPs most prevalent in children with autism. B C E H K M N O R U Y BOUNCY 1 1 1 1 1 1 BUYER 1 1 1 1 1 CHUNKY 1 1 1 1 1 1 HOCKEY 1 1 1 1 1 1 HONEY 1 1 1 1 1 MERCY 1 1 1 1 1 MONEY 1 1 1 1 1 MONKEY 1 1 1 1 1 1 RHYME 1 1 1 1 1 Transactions Items Sup (U, Y) = 3/9 No combination including M can possibly have a support higher than 4/9. Sup (M) = 4/9 Eliminating just one item (A) significantly reduces the number of combinations that need to be examined. A data mining technique that identifies common trends within a dataset. Items that don’t achieve a certain population prevalence (“Support”, or just “Sup”) are eliminated from future combinations. To address the challenge that complex diseases may have multiple causes, we use Contrast Mining. Contrast Mining 1. The population is divided into subpops based on one or more phenotypes. Nondysmorphic vs Dysmorphic : 464 : 80 FPM Contrast Mining 2. Frequent Pattern Mining identifies prevalent SNP combos for both subpops. 3. Prevalent combinations are compared to identify major discrepancies. High-Contrast Itemsets An itemset may be highly prevalent in a relevant subpop, even when that itemset does not pass the Min Sup threshold in the general population. This demonstrates the importance of Contrast Mining within heterogeneous populations. We plan to apply this Genomic Contrast Mining procedure to the SFARI dataset, searching for genetic distinctions between several known and suspected autism subgroups. We hope to identify genes that can ultimately be diagnostic for specific autism subtypes. This would lead to earlier and more specific diagnoses, allowing “Precision Medicine” treatments to be developed and administered to people with specific disease subtypes. We also plan to use SNP combinations to connect autism-related genes from animal models to genes previously unaffiliated with autism. The combined knowledge of genes relevant to autism in humans and those relevant to autism in rats can lead to discoveries unobtainable through the study of either organism individually. Future Work Acknowledgements This work is supported by the NIH 1T32LM012410-01 Training Grant. The computing infrastructure is supported by the NSF CNS- 1429294 Grant. The SFARI SSC data is provided by the Simons Foundation (SFARI award #26021565-08C000066 to J.M.). We use Apache Hadoop to store and manage genotype and intermediate data in a distributed fashion. We also use Apache Spark to perform computations, using the shared memory pool of many machines. To find associations between complex disease and multiple genes, we must generate combinations of SNPs to test for association. However, this leads to a explosion of SNP combinations. He


01 E 02 MARÇO DE 2023 RESTAURAÇÃO COM CIÊNCIA DO RIO DOCE Da Dimensão Edáfica ao Sensoriamento Remoto LOCAL: SALA 236 - BLOCO I3, ICB (UFMG) Foto: Odirlei Simões Saiba mais e se inscreva! RESTAURAÇÃO ECOLÓGICA DO RIO DOCE WOKSHOP DE Design: Walisson Kenedy Siqueira


19°0'0"E 18°E 17°E 16°E 15°E 14°E 13°E 45°N 44°N 43°N 42°N 41°N 40°N A B A -200 -1200 -500 (m) A B Slope section ADW NAdDW LIW -0 Deep water production area NAdDW LIW ADW 0 100 200 50 km Ionian Sea Tyrrhenian Sea Italy Adriatic Sea Me dit err an ea n Se a Adriatic Sea Pelagosa sill Otranto Strait Hotspot Ecosystem Research and Man's Impact On European Seas Final meeting 2012 Faro, Portugal, 11-14 September 2012 CONSIGLIO NAZIONALE DELLE RICERCHE Istituto di Scienze Marine 6 km N SE120 -850 -900 -950 -1000 m SE120 1 km E W E The reshaping of the South West Adriatic Margin by pervasive dense shelf water cascading A GIS-based methodology for quantitative geomorphological mapping Foglini F., Trincardi F., Campiani E. Istituto di Scienze Marine ISMAR – CNR, Bologna, Italy CONCLUSION 1. The morphological analysis suggests that the entire margin is undergoing a thorough re-shaping driven by the impact of a particular class of seasonally modulated bottom-trapped density cur- rents; 2. All these erosional and depositional features document how the dense shelf water cascading interacts with the pre- existing and markedly differentiated morphologies and sediment distribution; 3. The analysis of the bedform orienta- tion and spatial distribution make pos- sible to infer the pathway of the downslope-cascading bottom-currents. Trincardi, F., Foglini, F., Verdicchio, G., Asioli, A., Correggiari A., Minisini, D., Piva, A., Remia, A., Ridente, D., Taviani, M. 2007. The impact of cascading currents on the Bari Canyon System, SW-Adriatic Margin (Central Mediterranean). Mar. Geol., 246, Issues 2-4: 208-230. Trincardi, F., G. Verdicchio, and S. Miserocchi (2007), Seafloor evidence for the interaction between cascading and along-slope bottom water masse. J. Geophys. Res., 112, F03011, Verdicchio, G., Trincardi, F., 2006. Short-distance variability inabyssal bed-forms along the Southwestern Adriatic Margin (Central Mediterranean). Mar. Geol. 234: 271–292. The Southwest Adriatic Margin includes a steep and morphologi- cally complex continental slope stretching about 400 km from the Pelagosa sill to the Otranto strait. The area has been investigated through multibeam surveys accompanied by high-resolution seismic stratigraphic surveys investigating glacial and post-glacial deposits. After the end of the last glacial sea level low stand the North Adri- atic shallow shelf became progressively drowned as a consequence of the eustatic rise. Through its progressive drowning, this region became a shallow shelf and one of the Mediterranean key sites for the formation of dense shelf waters through wind-forced winter cooling. The dense waters formed through this process move to the south, along the western side of the Adriatic, and reach the South Adriatic slope across which they cascade hugging the sea floor and generat- ing a myriad of depositional and erosional effects such as: giant sediment drifts down to 1200m water depth, muddy and sandy sedi- ment waves, comet marks against pre-existing slide blocks, furrow fields, large scours at the shelf edge and large erosional moats against major morphological barriers. The fields of dominantly muddy sediment waves have a patchy distribution and appear to reflect the interaction between the down-slope path of the dense water and the presence of both morphological constraints to acceler- ate the flows and mobile sediment to be casted into wavy bedforms. Simplified intermediate- and deep-water circulation in the Adriatic Sea: NAdDW=North Adriatic Dense Water; LIW=Levantine Intermediate Water; ADW=Adriatic Dense Water. RESULTS Mud Wave fields Field A: The wave crests vary from slightly sinuous to bifurcated, with general ori- entation NE-SW. The wave heights are 10-30 m and the wavelengths in the region of 700-1300 m with wave crests up to 5500 m long. In cross section the sediment waves are asymmetric, with the depositional flank facing obliquely upslope. The opposite, downslope, flank is markedly less depositional


Phinch: An interactive, exploratory data visualization framework for metagenomic datasets! Raw data Formatted data structured for visualization User Interface for setting filters for data parsing Start by building 2 - 4 visualizations. Can add more later. Each visualization will have it’s own controls to adjust presets. This can then be shared or saved as PNG to embed in research papers. Project Schematic! The sheer volume of data produced from environmental sequencing approaches (rRNA marker genes, metagenomes) requires fundamentally different approaches and new paradigms for effective data analysis. Scientiﬁc visualization represents an innovative method towards tackling current bottlenecks; in addition to giving researchers a unique approach for exploring large datasets, it stands to empower biologists with the ability to conduct powerful analyses without requiring a deep level of computational knowledge. ! ! Here we present Phinch, an interactive, browser-based visualization framework that can be used to explore and analyze biological patterns in high-throughput environmental datasets. Leveraging a close collaboration between UC Davis and Pitch Interactive (a data visualization studio in Berkeley, CA), this project takes advantage of standard ﬁle formats from computational pipelines in order to bridge the gap between biological software (e.g. QIIME) and existing data visualization capabilities (harnessing the ﬂexibility and scalability of WebGL and HTML5, and visualization-speciﬁc programming language such as Processing and D3).! ! Taxonomy Bar Bubble Chart Sankey Diagram Donut Partition Attributes Column Chart Bubble Chart By OTU http://phinch.org!


Rohdaten Recherche zu Meta- und Kontextdaten von Institutionen/Personen/ Journalen/Verlagen/ Universität Aufnahme in die Datenbank Digitalisate kaum verwertbare Volltexte/ OCR Bearbeitung aller Journale nicht möglich Händische Erschließung über Inhaltsverzeichnisse/ Verzeichnung in Relationaler Datenbank Netzwerke des Wissens Thematische und personelle Relationen innerhalb der halleschen Zeitungen und Zeitschriften der Aufklärungsepoche (1688-1815) Anne Purschwitz Fragestellung Wie, wann, wo und warum wurde während der Aufklärung Wissen in Form öffentlicher Diskurse gesammelt, verbreitet oder genutzt – unterdrückt, vernachlässigt oder ignoriert? Wer waren die darin involvierten Aktanten und wie gestalteten sich die damit einhergehenden Netzwerke? Keiner der Ansätze allein würde eine solche Fülle von Daten berücksichtigen können und flexibel angepasste Interpretationen ermöglichen. Individuelle Anpassungsmöglich- keiten/Abfragen je nach thematischer, inhaltlicher oder zeitlicher Fokussierung. Verfahren zwingen Daten in allen ihren Widersprüchlichkei- ten und auch mangelnden Plausibilitäten ernst zu nehmen. In Visualisierungen Trennung von Bild und Geschichte – braucht Interpreta- tion, Kontext, Erklärung. Datengrundlage nur erweiterbar bei guter Dokumentation und Pflege. Generierung Gesamt- datensatz: umfang- reiche Datenerhebung (Metadaten, Informa- tionen zu Aktanten etc.). Vor- und Nachteile Vorteile Nachteile 360 in Halle begründete Zeitungen und Zeitschriften 1688-1815/ 1.300 Bände/ 3.900 Stück/ 2.800 Personen Beiden Verfahren innewohnende statistische Grundlagen ermöglichen Vergleichbarkeit. Preprocessing für TopicModelling sehr zeitaufwendig. Topic Modelling Praktische Anwendung Ähnlichkeit der Farben weist auf Ähnlichkeit der Themen hin/ farbige Punkte neben Dokumenten zeigen Themenzuweisung preprocessing Bereinigung Wortlisten/ Stoppwörter/ Sprachanpassungen/ Übersetzungen/ Normalisierung Schreibweisen/ Part-Of-Speech tagging Datengrundlage bibliographisch erfasste und mit Metadaten angereicherte Inhaltsverzeichnisse/ Nutzung des von Alexander Hinneburg entwickelten TopicExplorers Zielsetzung Identifizierung von Themen durch unüber- wachtes maschinelles Lernen Ergebnisse Topic Modelling Visualisierung einige Themen lassen Verständlichkeit in Wortlisten erkennen/ Themen können in ihrem zeitlichen Verlauf dargestellt werden offene Fragen entgegen Erwartungen ‚fehlen‘ Themen – z.B. ‚Aufklärung‘, Suche nach Ursachen, Erklärungen Abfragen für jedes Thema kann SQL-DB abgefragt werden/ welche Autoren und/oder Journale zu welchem Zeitpunkt involviert/erstellen hierarchischer Listen Überführung in NWA möglich Generierte Themen beinhalten keinerlei Interpretation Ergebnisse Entwicklungs- tendenzen Entwicklung des Pressemarktes in vier Zeitschnitten dominierende Journale Journale, die Vielzahl von Themen bedienen in zentralen Positionen/meist Rezensionszeitschriften ohne fachlichen Schwerpunkt/Naturkunde im Aufschwung/viel praktisches Wissen dominierende Themen zentrale Themen über Gesamtzeitraum: Rezensionen zu politischen Schwerpunkten/Rezensionen zu theologi- schen Schriften/beschreibende Artikel zur Natur und Geographie unterschiedlicher Länder/ Themen, die nur punktuell oder spät aufkommen am Rand des Netzwerks/ dynamische Modellierung ermöglicht Hinterfragen von Entwicklungen und Verschiebungen Layout: Katrin Sillmann Kombination Topic-Modelling und Netzwerk- analyse (NWA) Fragestellung Kann NWA bei der Erklärung der generierten Topics hilfreich sein? Inwiefern kann Einbeziehung zusätzlicher Metadaten durch NWA ge- lingen? praktische Anwendung Umwandlung Listen TopicExplorer in Knoten und Kanten/ ergänzen weiterer Eigenschaften/ Attribute/NWA-Tool Gephi/vielfältige Selek- tionsmöglichkeiten


Effect of acorn feeding on quality and aromatic profile of dry sausages produced from Turopolje pigs D. Karolyi1, N. Marušić Radovčić2, H. Medić2, Z. Luković+, U. Tomažin3, M. Škrlep3 and M. Čandek Potokar3 1University of Zagreb, Faculty of Agriculture, Svetošimunska 25, 10000 Zagreb, Croatia, 2University of Zagreb, Faculty of Food Technology and Biotechnology, Pierottijeva 6, 10000 Zagreb, Croatia, 3Agricultural institute of Slovenia, Hacquetova ulica 17, 1000 Ljubljana, Slovenia; dkarolyi@agr.hr Turopolje pig (TP) is an endangered Croatian autochthonous breed typically reared in an outdoor production system linked to local oak forests and marsh meadows in Turopolje region in Central Croatia. To self-sustain TP breed the utilization of meat products with added value has recently been proposed in TREASURE project. So far little information is available on the quality attributes of TP meat products, including the effect of locally available feeding resources. Hence present study aimed to examine the quality and aromatic profile of dry-fermented sausages of TP that were reared in similar conditions but fed either conventional (CF) or acorn supplemented (AF) finishing diet. The quality of end product, pH and aw values, moisture, fat and protein content, fatty acid (FA) profile, oxidative stability, texture profile analysis (TPA), sensory evaluation and aromatic profile were determined. Data were analysed by TTEST or NPAR1WAY (for sensory data) procedure at an alpha level of 0.05. Compared to CF, AF sausages tended (P<0.1) to have higher moisture content and TPA chewiness, but generally had similar physicochemical, rheological and sensorial traits and FA composition, except for higher share of C14:0. Lipid oxidation, measured as 2-thiobarbituric acid-reactive substances, was more pronounced in AF than CF sausages. Aromagram showed terpenes as the most abundant volatiles (around 52% of the total area) in both types of sausages, followed by aldehydes (11-14%), aromatic hydrocarbons (6-10%), phenols (6-7%), alcohols (5-6%), acids (4-6%), Sulphur compounds (2- 5%), ketones (around 3%), esters (less than 2%) and aliphatic hydrocarbons (less than 1%). Compared to CF, AF sausages had less aromatic and aliphatic hydrocarbons and sulphur compounds, and more esters. These results suggest that acorn feeding may affect some properties of TP dry-fermented sausages but more research is needed. Funded by European Union’s H2020 RIA program (grant agreement no. 634476).


. Sparger Overlay N2 N2 Methods Results The views expressed are purely those of the author(s) and may not in any circumstances be regarded as stating an official position of the European Commission. This poster is part of the European Joint Programme One Health EJP. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No 773830. Effect of nitrogen gassing strategy on the in vitro cultured chicken caecal microbiota Ingrid Cardenas Rey1,2 • Teresita Bello Gonzalez1 • Kees Veldman1 • Arjan de Visser2 • Michael Brouwer1 1. Dept. of Bacteriology, Host-Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research, Lelystad, The Netherlands • 2. Laboratory of Genetics, Wageningen University and Research, Wageningen, The Netherlands. In vitro models are cost-efficient tools to study animal gut microbiota dynamics with controlled conditions without the ethical implications of animal studies. Nevertheless, the continuous optimisation of in vitro models is imperative to reduce experimental bias and generate reliable data. Here, we have tested the effect of two nitrogen gassing strategies (overlay vs sparger) on the chicken caecal microbiota composition over time using a continuous single-stage fermentation culture system. Conclusions Experimental conditions were set up identically in two bioreactors except for their anaerobic environment; in one nitrogen was supplied on the top of the culture (overlay) while in the other nitrogen was sparged directly into the culture (sparger). Bioreactors were inoculated with an identical cryopreserved pool of caecal content from adult chickens and the in vitro chicken caecal physiological conditions (temperature, pH, caecal movements, and reduced levels of oxygen) were real-time monitored overtime (Fig. 1). Samples were collected daily (day 0 - 8) for 16S rRNA gene sequencing and downstream analyses. Figure 2. Real-time monitored conditions (pH, temperature, dissolved oxygen (dO2)). Overlay and Sparger in light and dark colour, respectively. Figure 3. Alpha and beta diversity analyses of the in vitro chicken caecal microbiota in both bioreactors (overlay and sparger) a. Observed microbial richness over time (ASV; Amplicon sequence variant) b. Principal coordinate analysis showing changes in the microbial community composition over time c. Comparison of the top ten genera relative abundance over time. a b c In vitro simulated chicken caecal conditions remained stable over time (Fig. 2). Most variability was observed in the pH due to microbial activity. Microbiota analysis • Microbial richness fluctuated daily in both bioreactors (Fig. 3a). • Experiment time explained 63% of the compositional variation of the in vitro microbiota (p < 0,001) while the gassing strategy explained 4% (Fig. 3b). • Anaerobes as Butyricicoccus (Fig. 3c) and Lachnospiraceae were significantly higher (p < 0,001) in sparger than overlay. Contact: Ingrid.cardenasrey@wur.nl Acknowledgements Part of this work was funded by the Dutch Ministry of Agriculture, Nature and Food Quality. Our continuous single-stage in vitro model simulated the conditions necessary to closely reproduce the main taxa of the chicken caecal microbiota. However, our results also show that the choice of experimental settings, in our case gassing type, has an impact on the in vitro cultured microbial community composition over time. Thus, pre-testing optimisation and standardisation of in vitro systems should be considered as vital to reduce bias and draw meaningful conclusions. Further work: to study the effect of interventions (e.g. synbiotics) on the horizontal transmission of antimicrobial resistance genes in the in vitro chicken gut microbiota. Figure 1. Experimental set-up showing a. Origen of the initial caecal inoculum b. Two strategies of nitrogen delivery (sparger and overlay) on the in vitro chicken caecal microbiota.


Introduction The feral population of primitive Soay sheep on the remote island of St Kilda, in the North Atlantic Ocean, provides a unique research resource where scientists have been studying related evolutionary genetics and population dynamics for decades. The island is covered in vegetation typical of many upland areas along the west coast of Britain. Research & Aim This study is specifically addressing unanswered questions associated with plant - herbivore interactions. The aim is to further validate the the application of faecal DNA metabarcoding to fully determine diet composition in herbivores. Further decision making & development of predictive models used for ecosystem conservation management. Support optimal grazing regimes within extensive sheep systems. Support reducing the need for anthelmintic drugs whilst improving animal nutrition via grazing management. Provide knowledge to avoiding over- exploitation and depletion of habitat resources. Knowledge gained will improve: Diet studies have not previously been undertaken on the island due to the challenges associated with determining diet composition by free ranging animals. However, as there are no competitors nor predators the population is naturally regulated and co-dependent on the availability of resources such as food availability and nutritional quality, providing an ideal system to study plant-herbivore interactions. Project Outputs Provide insight into how dietary preference of sheep differ at e.g. different ages and times of the year. This information will increase our understanding of interactions between diet choice, immunity, gut bacteria and parasite burden in both wild and domesticated herbivore populations. How can studying Soay sheep on St Kilda help conservation and farming in the Welsh uplands? H.E.Vallin* (a), M.D.Fraser, H.Hipperson (b) (a) Pwllpeiran Upland Research Centre, Aberystwyth University. (b) Department of Animal and Plant Sciences, University of Sheffield. Question: Can faecal DNA metabarcoding determine the quantitative composition of herbivore diets down to species classification? *hev1@aber.ac.uk Pwllpeiran Upland Research Centre, Aberystwyth University, Cwymystwyth, Aberystwyth, SY23 4AB, UK This project is funded by NERC Methods Regular non-invasive faecal sampling from known individuals for DNA meta-barcoding to determine botanical composition of consumed diet.


Improving Data Stewardship with the DMPTool: Helping Libraries Promote Data Management Dan Phipps & Carly Strasser | daniel.phipps@ucop.edu | carly.strasser@ucop.edu This project is sponsored by With a little help from our friends: In brief: We received funds from the IMLS to build resources around the DMPTool for librarians. We want to equip librarians to provide data management services for their institution’s researchers and other stakeholders Project Goals: • Centralize existing resources • Provide outreach materials around the DMPTool • Build a community of sharing ideas & resources Why librarians? • Long-‐standing tradition of service & preservation • Opportunity to ﬁll data education void, provide valuable research support What is the DMPTool? Coming soon: DMPTool2 Deliverables Webinars & Course Certiﬁcate Outreach Kit Web Content 28 May Introduc/on to the DMPTool 4 June Learning about data management: Resources, tools, materials 18 June Customizing the DMPTool for your ins/tu/on 25 June Environmental Scan: Who's important at your campus 9 July Promo/ng ins/tu/onal services; EZID Outreach Made Simple! 16 July Health Sciences & DMPTool -‐ Lisa Federer, UCLA 23 July Digital humani/es and the DMPTool -‐ Miriam Posner, UCLA 13 Aug Data cura/on proﬁles and the DMPTool – Jake Carlson, Purdue How to give the data management sales pitch to various audiences Other tools and resources that work with/complement the DMPTool Beyond funder requirements: more extensive DMPs Case studies 1 – How librarians have successfully used the tool Case studies 2 – How librarians have successfully used the tool Outreach Kit Introduc/on Cer/ﬁca/on program introduc/on CERTIFICATION COURSE Free step-‐by-‐step web application for creating data management plans for funders Founding partners: DataONE; Digital Curation Centre; Smithsonian Institution; UC Curation Center, California Digital Library; UCLA Library; UC San Diego Libraries; University of Illinois; University of Virginia Libraries General & institution-‐ speciﬁc resources Funder-‐provided information & plan outline Suggested answers & help text Space to answer questions Log in with institution credentials Learn more at dmptool.org bitbucket.org/dmptool/main blog.dmptool.org dmptool.org For administrators: • Beber plan template granularity (discipline, funder, ques/on) • Beber ins/tu/on granularity (department, college, lab group, …) • Role-‐based user authoriza/on & access • Enhanced search and browse of plans • Access to metrics for repor/ng & follow-‐up For plan creators: • DMP life cycle management • Collabora/ve plan crea/on • Role-‐based user authoriza/on & access • Beber plan templates & resources Plus… • Ins/tu/onal branding • Open API DMPTool2: Responding to the Community Promotional Materials Presentation Templates Customizable LibGuides


Cited literature: (1) Sullivan, L.M., Massaro, J.M. and D'AgosƟno, R.B., Sr. (2004). PresentaƟon of mulƟvariate data for clinical use: The Framingham Study risk score funcƟons. StaƟst. Med., 23: 1631-1660. (2) World Health Organizaton (2015). Guidelines for the prevenƟon, care and treatment of persons with chronic hepaƟƟs B infecƟon. ISBN: 978-92-4-154905-9. (3) Shimakawa, Y. et al. (2018). Development of a simple score based on HBeAg and ALT for selecƟng paƟents for HBV treatment in Africa. J. Hepatol. 69, 776–784. AﬃliaƟons: (1) Insitut Pasteur, Paris, France, (2) Vesƞold Hospital, Tønsberg, Norway, (3) University of Oslo, Oslo, Norway, (4) Bogodogo University Hospital Center, Ouagadougou, Burkina Faso, (5) University of Bern, Bern, Switzerland, (6) University of Zambia, Lusaka, Zambia, (7) University of Alabama at Birmingham, Birmingham, United States, (8) Tygerberg Hospital and Stellenbosch University, Stellenbosch, South Africa, (9) InsƟtute of InfecƟon, Veterinary and Ecological Sciences, Liverpool, United Kingdom, (10) Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi, (11) University of Cape Town, Cape Town, South Africa, (12) Yalgado Ouédraogo University Hospital Center, Ouagadougou, Burkina Faso, (13) Centre Regional de Recherche et de FormaƟon, Centre Hospitalier NaƟonal Universitaire de Fann, Dakar, Senegal, (14) Liverpool School of Tropical Medicine, Liverpool, United Kingdom, (15) Faculty of Medical Sciences, University of Jos, Jos, Nigeria, (16) Imperial College London, London, United Kingdom, (17) London School of Hygiene & Tropical Medicine, Banjul, Gambia, (18) University of Oxford, Oxford, United Kingdom, (19) The Francis Crick InsƟtute, London, United Kingdom, (20) University College, London Hospitals, London, United Kingdom, (21) Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, South Africa, (22) St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, (23) Hopital Principal de Dakar, Dakar, Senegal. In sub-Saharan Africa, clinical reference standard to assess eligibility for treatment (HBV DNA PCR, transient elastography, liver biopsy) is oŌen restricted to naƟonal-level centers. To improve uptake of anƟ-HBV therapy, we need either signiﬁcant investment to make viral load tesƟng available even at peripheral health faciliƟes, or the development of simpliﬁed eligiblity criteria. Here, we found that a combinaƟon of platelet counts, AST and ALT levels - tests available even at low level health faciliƟes - can idenƟfy the majority of HBV-infected people in need of AVT. Our results suggest that even in the absence of upgrades in laboratory and radiology, decentralizaƟon of clinical staging for HBV-infected people may be realized in SSA. Conclusion Performance of diﬀerent guidelines and scoring systems, in the validation dataset. Because it relies on biopsy or liver sƟﬀness measurments, clinical reference standard (EASL 2017 guidelines) are only available in TIER4 level faciliƟes. Two eligibility evaluaƟon tools have already been proposed in the past years. WHO 2015 guidelines relies notably on viral load (VL) and are available at TIER3 level faciliƟes (or above). They fall short of detecting half of eligible persons (38% sensitivity), but keep high speciﬁcity (98%), leading to an overall AUROC of 0·68 [0·64–0·72]. TREAT-B scoring system requires HBeAg testing, and is thus available at TIER3 level facilities. It achieves 0·87 [0·84–0·90] AUROC, with 88% sensitivity and 86% speciﬁcity. Our simple scoring system, available in TIER2, achieves comparable results, with 0·83 [0·79–0·86] AUROC, 79% speciﬁcity, and 87% sensitivity in the validation dataset. However, it only relies on platelet and transaminases, and is thus available at TIER2 level faciltities Test n AUROC Se (%) Sp (%) TP FN FP TN HEPSANET scoring system 1452 0·83 [0·79, 0·86] 79 87 117 31 174 1130 WHO 2015 guidelines 1439 0·68 [0·64, 0·72] 38 56 98 92 28 1276 TREAT-B 1439 0·87 [0·84,