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MODELLING ACTIVITY-INDUCED RADIAL VELOCITIES THROUGH STELLA/WiFSIP SIMULTANEOUS PHOTOMETRY A. Castro-González1, J. Lillo-Box1, and the KOBE team2-6 1Centro de Astrobiología, 2Universidade do Porto, 3Universidad de Cádiz, 4Aix-Marseille Université, 5Instituto de Astrofísica de Andalucía, 6Observatorio de Calar Alto The KOBE experiment (K-dwarfs Orbited by Habitable Exoplanets; Lillo-Box et al. 2022, submitted) is aimed at searching for new worlds within the habitable zone (HZ) of K-dwarf stars through the radial velocity method using the CARMENES spectrograph. The survey is currently monitoring 50 pre-selected late K-dwarf stars, where we expect to find a significant number of planets according to planet occurrence rates in this stellar regime. K-dwarf stars are the ideal hosts to search for planets in the HZ. Contrary to G-dwarfs, the HZ is closer, thus making planet detection easier. And contrary to M-dwarfs, the stellar activity is much smaller, hence having a lower impact in the detectability and in the true habitability of the planet. Despite this, there is a desert of habitable worlds around K-dwarfs due to the lack of surveys devoted to this parameter space. In Fig. 1 we show 2 years of 3-day cadence simulated WiFSIP photometry and 9-day cadence CARMENES data for a typical target of our sample. We used the SOAP2 package (Dumusque et al. 2014) to simulate the photometric and spectroscopic effects of two spots covering 0.38% of the stellar surface, and two plages covering 1.68%. We then injected a simulated Keplerian signal of 4 m/s in an orbital period of 86.5 days. We analysed the simulated dataset by both using and not using the photometric time series. Our results show that in this simulation the planet is detected in both cases but the planet properties are a 30% more precise when using the photometric time series. For lower-mass planet simulations we find that only when using the WiFSIP photometry we can significantly detect the signal. K-dwarfs are among the most quiet stars in terms of activity. However, the low-amplitude RV signals from HZ planets can be disturbed by the presence of active regions. A key technique to achieve very precise RV measurements consists of simultaneously characterizing this stellar activity by measuring the so-called activity indicators. These indicators can be obtained from the spectra from which the RV is acquired or from additional observations (e.g. photometry has been proved to be a good indicator; Aigrain et al. 2012). The vast majority of works that take into account activity indicators, make use of those extracted from the RV spectra alone, due to its observational simplicity. However, the KOBE long-cadence of 9 days is not enough to properly sample the activity of K dwarfs. With typical rotation periods of 40 days (and a range between 10-50 days, McQuillan et al. 2014), the RV cadence would only sample up to 5 data points per stellar rotation. We fit the spectroscopic and photometric data through a Bayesian approach combined with a Markov chain Monte Carlo (MCMC) sampling. The signals caused by stellar activity can be seen as correlated quasi-periodic noise. To deal with it, Gaussian Processes (GP) are an increasingly common tool. Thus, we model the RV through a Keplerian and a GP, and jointly we model the full width of half maximum (FWHM) of the cross correlation function (CCF) and the photometric time series through GPs with shared hyperparameters. In particular, we use a quasi-periodic kernel of the form where 𝜂1 is the amplitude of the correlations, 𝜂2 is the timescale of the correlation decay, 𝜂3 defines the periodic component and 𝜂4 controls the relative importance of the periodic and decaying components. Methodology References. 1. Aigrain S., Pont F., Zucker S., 2012, MNRAS, 419, 3147. 2. McQuillan A., Mazeh T., & Aigrain S., 2014, ApJS, 211, 24. 3. Dumusque X., Boisse I., & Santos N. C. 2014, ApJ, 796, 132. Figure 1. Simulated RV, FWHM and photometry for a typical target | poster |
Electricity Demand and Opportunity at The Island School Benjamin Bradford, Brooke Chappell, Dawit Hawgood, Alexander Hee, Benjamin Immerman, Maya Lindeman, and Marley Spitler Advisors: Brett Ziter, Grace Alberts, and Gustav Wellin Introduction Methods Discussion Results Acknowledgements Literature Cited There are seven systems that provide electricity to The Island School. Five use renewable sources. The others are diesel back- up and diesel from the grid. This figure provides a visual representation of the electricity systems on campus, categorized by energy source. Not pictured is The Island School’s connections to the local electricity grid. This figure shows the production of each electricity system at The Island School over one representative month. This research aims to lower the school’s dependence on the diesel grid and instead generate more elec- tricity from renewables. • Boathouse solar system has a capacity of 18 kW AC. • Treehouse solar system has a capacity of 12 kW AC. • Hallig solar system has a capacity of 3.3 kW AC. • Wet lab solar system has a capacity of 31 kW AC. • The wind turbine has a capacity of 10 kW AC. Electricity Systems Electricity consumption can be measured using a data acquisition system like The Island School’s proprietary CampIS. This system measures how much electricity is used on campus and how much flows to and from the power grid. CampIS was used here to determine the total amount of elec- tricity consumed at The Island School and how much was generated from renewable sources. This figure shows some of the information available on The Island School’s CampIS Data Acquisition System Next, data from the solar inverters were analyzed to identify trends and patterns. The recorded power output of the inverters was compared to the expected power output based on the number and type of solar panels within each system. This type of comparison allows problems to be de- tected, isolated, and ultimately solved. This figure shows an example of how expected outputs can be compared to real data, to identify problems System Fix Date Result Wet Lab Arc Fault Isolation Feb 1 +11% Hallig Reboot Feb 26 +2% Treehouse Wiring Problem Mar 11 +2% All Solar Grid compatibility improvement Mar 6-10 +5-10% Wind Turbine Blade maintenance & Re-commissioning Future +4% This table provides a summary of the issues identified across The Island School’s renewable energy systems and their associated improvements. *Results indicate percentage of total electricity offset at the school Since The Island School’s founding in 1999, global energy consumption has risen by 50%. The majority of energy is produced using fossil fuels like coal, oil, and gas. Carbon emissions from fossil fuels have led to rising global temperatures, and the resulting impacts of climate change. Eleuthera heavily depends on burning diesel to generate electricity. Small islands such as Eleuthera are particularly vulnerable to climate change and global warming, as they have many natural risks like rising sea levels and intensified hurricanes. Eleuthera occupies a remote area with limited access to resources and relies on vulnerable natural ecosystems like fisheries and coral reefs. Given The Island School’s position of leadership and access to resources relative to others on Eleuthe- ra, it is important for the school to optimize the way it produces and consumes electricity. Objectives • Measure campus’ total electricity consumption • Determine the amount of consumption coming from diesel vs. renewable sources • Find the potential electricity production if each campus system is optimized • Investigate climate impacts – find the carbon emissions and diesel that can be avoided This figure shows the relationships between fuel consumption, CO2 emissions, and global temperature rise The Island School used 300,000 kWh of electricity in 2023, Requiring 85,000 L of diesel and emitting 230,000 kg of CO2. Several small fixes have allowed the school to increase its prop | poster |
Nom Équipe 0 900 1800 0 1000 2000 3000 Channel 2% 25% 75% Nom Équipe Elaboration of Rare Earth Oxide Thin Films for Quantum Technologies N. Harada1, A. Tallaire1,2, A. Ferrier1,3 , M. Scarafagio1, D. Serrano1 and Ph. Goldner1 1PSL Research University, Chimie ParisTech-CNRS, Institut de Recherche de Chimie Paris, 75005 Paris, France 2Laboratoire des Sciences et Procédés des Matériaux (LSPM) ,Université Paris 13, 93430, Villetaneuse, France 3Sorbonne Universités, UPMC Université Paris 06, 75005, Paris, France Abstract Results and Discussion DLI-CVD for Eu3+:Y2O3 thin films Rare earth ions (REI applications: • Lighting / Screens / Lasers • Electronic devices • Scintillators • Sensors References Conclusion & Perspectives Funding Effect of doping on optical properties 515250 515500 515750 516000 516250 516500 516750 517000 517250 0 1 2 3 4 5 6 7 8 100% 75% 50% 25% 8% 5% 4% 2% 1% 0,5% 0,25% Intensity (A.U) Frequency (GHz) Thin films: • Scalability and processing Eu3+:Y2O3 thin layer, made by Atomic Layer Deposition Introduction Increasing thickness 20 40 60 0,0 0,9 1,8 2,7 Normalized Intensity (a.u) 2 theta Study of deposition temperature in Y2O3 Morphological properties of undoped Y2O3 Y2O3 (222) Y2O3 (400) Si (211) • T < 450°C : No growth = insufficient kinetics • Kinetic regime = T drives growth • Diffusion regime = sufficient kinetic • Decomposition of gaseous precursor Study of doping in Eu3+:Y2O3 • Play with the amount of precursor injected = Control the doping 28.0 28.8 29.6 0.0 0.5 1.0 1% (222) 2% (222) 4% 8% 25% 50% 75% 100% 1% (222) ! (!) 0 50 100 150 200 250 1E-4 1E-3 0.01 0.1 1 100% Eu 75% 50 % 612 nm 25% 612 nm 10% 612 nm 4% 612 nm Temps (µs) Eu Y Si (substrate) O %Eu Conclusion • Parametric study of DLI-CVD process good quality films obtained in a wide doping range • Eu3+:Y2O3 thin film properties encouraging Perspectives • Epitaxial growth to improve crystalline quality • Measure coherence properties (Spectral Hole Burning) • Towards other systems such as Y2SiO5 • Polycrystalline and columnar growth • Grain size 30-100nm 50 nm 90nm 250 nm 650 nm SEM pictures of Y2O3 thin films XRD diffractogram of Y2O3 thin film • Rutherford Backscattering Spectroscopy spectrum Check the effective doping %Eu XRD of Y2O3 (222) peak • Evolution of the growth rate with T Precursor : Y(TMHD)3 0,0008 0,0010 0,0012 0,0014 0,0016 0,0018 0,0020 0,0022 0,0024 -5 -4 -3 -2 -1 0 ln(Growth Rate) 1/T 450 500 550 650 750 850 950 1050 1150 T 5 D2 5 D1 5 D0 7 F2 7 F1 7 F0 465nm 612nm Quenching = Energy transfer from ion-ion or ion-defects • Ratio for randomly oriented Y2O3 powder : (222)/(400) = 4 • Effective ratio here : (222)/(400) > 10 Strong (111) texture of Y2O3 thin layer Experiments conducted in collaboration with JJ.Ganem and I.Vickridge, INSP • Doping goes from Y2O3 to Eu2O3 increase lattice parameter • Photoluminescence • Lifetime Normailzed intensity • Inhomogeneous linewidth Theory Eu3+ Crystal Wavelength 5 D0 7 F2 7 F1 7 F0 580.68nm 612nm Experiment • Shift and broadening of the inhomogeneous linewidth Eu3+environment changes Inhomogeneous linewidth • P. Goldner, et al., “Recent Advances in Rare Earth Doped Inorganic Crystalline Materials for Quantum Information Processing”, Zeitschrift für Anorganische und Allgemeine Chemie; Feb2018, Vol. 644 Issue 2, p66-76, 11p • S. Liu, et al., "Controlled size reduction of rare earth doped nanoparticles for optical quantum technologies," RSC Advances, 8 (2018) 37098-37104. • M. Scarafagio et al., « Ultrathin Eu- and Er-Doped Y2O3 Films with Optimized Properties for Quantum Technologies », The Journal of Physical Chemistry C 2019 123 (21) Quantum technologies (QT) with REI: • Superposition state • Quantum Computer / Cryptography • Quantum memory Classic al Bit Qubit REI properties: • Photostable centers 4f-4f transitions shielded by closed shells • Good luminescence properties • Wide range of emissions • Optical and hyperfine transitions addressable Nanoparticles : • Easier coupling to cavities o | poster |
Walker Institute for Climate System Research www.walker-institute.ac.uk Model configuration ● FAMOUS-CI is an Earth System Model based on the HadCM3 atmosphere-ocean general circulation model ● It has optional representations of the marine and land carbon cycles, along with two-way coupling to an ice- sheet model ● FAMOUS can integrate ~100 model years per day on high performance computing resources, and has also been installed on desktop machines FAMOUS-CI a fast Earth System GCM Robin S. Smith¹, Annette Osprey¹, Oli Browne¹ and Jonathan Gregory¹׳² (r.s.smith@reading.ac.uk) ¹NCAS-Climate, University of Reading, ²Hadley Centre, UK Met Office FAMOUS-CI is an Earth System model, based on HadCM3, that has been de- veloped in the UK jointly by NCAS, the Hadley Centre, Bristol University and the QUEST and RAPID programmes. It has roughly half the spatial resolution of HadCM3, but retains all the complex processes that are represented in an AOGCM. FAMOUS-CI includes some processes not modelled in HadCM3; the fully coupled carbon cycle and ice-sheet models allow it to be applied to a wide variety of climate problems. HadAM3 HadOM3 MOSES GLIMMER HadOCC TRIFFID Atmosphere: 5.0˚x7.5˚, 11 levels Ocean: 2.5˚x3.75˚, 20 levels Dynamic Vegetation Land Surface Grounded Ice Sheets NPZD biogeochemistry www.famous.ac.uk For more information on FAMOUS, please visit our website. Here you’ll find information about getting and running FAMOUS, as well as access to our mailing list, links to the different projects in the FAMOUS community and announcments of new developments. FAMOUS Climatology Climate Simulations Classifying the preindustrial climate simulated by FAMOUS into the Köppen-Geiger climate zones shows that FAMOUS does a good job of simulating both the mean climate and seasonal variability of a modern cli- mate. Accelerated transient runs through the last glacial cycle are being used to in- vestigate the influences of different forcing factors on the climate and at- mospheric CO2 further demonstrate that the climate sensitivity in FAMOUS is realistic. FAMOUS has also been coupled to the Glimmer ice-sheet model, and has been used to investigate icesheet- climate feedbacks during glacial in- ception. Main climate - A: equatorial; B: arid; C: warm temperate; D: snow; E: polar. Precipitation - W: desert; S: Steppe; f: fully humid; s: summer dry; w: winter dry; m: monsoonal. Temperature - h: hot arid; k: cold arid; a: hot summer; b: warm summer; c: cool summer; d: extremely continental; F: polar frost; T: polar tundra The relatively low spatial resolution of FAMOUS means that it has lower computational requirements that most climate GCMs. FAMOUS can simulate around 100 model years per day using 8 processors of a high performance cluster, making millennial-scale transients and ensemble runs feasible. Like HadCM3, FAMOUS-CI does not require flux adjustments to produce a stable, reasonable simulation of modern climate. The global climate sensitivity to CO2 forcing is also very similar to that of HadCM3. Developing the common “Atlantic hosing” experiment further, an ensemble run of FAMOUS has been used to investi- gate the sensitivity of the Atlantic meridi- onal overturning circulation (AMOC) to the location of an applied freshwater flux. 0.5Sv of freshwater were applied to either the east (E) or west (W) side of the basin at a given latitude, with a second group of experiments where both east and west were hosed simultaneously (A). The AMOC weakens differently dependent on the location of the hosing, with corre- sponding differences in surface tempera- ture change. These results closely mirror the model-dependent response of the AMOC in intercomparisons, suggesting that the geography of the deepwater for- mation in the models is an important dif- ference. Some local warming was also observed to result from the AMOC de- cline. In some experiments central Green- land temperatures were found to warm whilst the wider North Atlantic cools. FAMOUS runs: | poster |
RESEARCH POSTER PRESENTATION DESIGN © 2012 www.PosterPresentations.com PERCEPTION TOWARDS PREPAREDNESS FOR DISASTER MANAGEMENT AMONG COMMUNITY HEALTH NURSES Nor Marini Mohamed, Lailatul Hazzliza Musa, Fatimah Sham, Norjah Othman, Nurul Liana Roslan Emergency And Trauma Department, Hospital Kuala Lumpur. Disasters are defined as extraordinary events which occur abruptly, bringing great damage or harm, loss, and destruction to people and the environment. Nurses may have a more conflict and difficulties in disaster decision making where the victim condition need to be treated in disaster place. Nurses play a key role in hospital as a leaders and managers in the disaster operation and command center but limited data shows that the nurses experience in disaster management. INTRODUCTION OBJECTIVE A descriptive cross-sectional study was conducted in 27 government clinics in one of the states in Malaysia with a convenient sampling, 260 participants are selected. The questionnaire consisted of three sections; socio-demographic characteristics, the perception of knowledge and skill towards preparedness for disaster management rated on a Likert scale. In the effort to collect the intended data, a self-report questionnaire adapted and modified from Disaster Preparedness Evaluation Tool (DPET) was implemented (Alrazeeni, 2015). Inclusion criteria: • Nurses who are working in Community Health Clinic in JKWPKL. • Agreed to participate in this study Exclusion criteria: • Disagreed to participate in this study This study was registered under National Medical Research Register for Medical Research (NMRR-16-2626-33093) and approved by the UiTM Research Ethics Committee (600-RMI (5/1/6), Community Research Centre (CRC) Hospital Kuala Lumpur (HKL/CRC/SL/06) and Medical Research Ethics Committee (MREC); (5) KKM/NIHSEC/P17-560 METHODOLOGY RESULTS (DEMOGRAPHIC CHARACTERISTICS) REFERENCES Ahayalimudin, N. A., & Osman, N. N. S. (2016). Disaster management: Emergency nursing and medical personnel’s knowledge, attitude and practices of the East Coast region hospitals of Malaysia. Australasian Emergency Nursing Journal, 19(4), 203–209. Al Thobaity, A., Plummer, V., Innes, K., & Copnell, B. (2015). Perceptions of knowledge of disaster management among military and civilian nurses in Saudi Arabia. Australasian Emergency Nursing Journal, 18(3), 156–164 . Alrazeeni, D. (2015). Saudi EMS Students’ Perception of and Attitudes toward their Preparedness for Disaster Management, 6(35), 110–116. Diab, G. M., & Mabrouk, S. M. (2015). The effect of guidance booklet on knowledge and attitudes of nurses regarding disaster preparedness at hospitals. Journal of Nursing Education and Practice, 5(9), 17–31. Hammad, K. S., Arbon, P., Gebbie, K., & Hutton, A. (2012). Nursing in the emergency department (ED) during a disaster: A review of the current literature. Australasian Emergency Nursing Journal, 15(4), 235–244. Ismail, A., Ghazi, H. F., & Unit, C. M. (2016). Disaster Management : Identifying Knowledge of Emergency Nurses and Community Health Nurses and Its Predictors in, 16(3), 66–74 Magnaye, B., M, M. S. M. L., Ann, F. M. M., Gilbert, V. M. R., & Heather, M. J. (2011). the Role , Preparedness and Management of Nurses During Disasters. E-International Scientific Research Journal, III(4), 294 . We would like to anknowledgement and appreciate those individual that were so helpful in assisting us to reach our goal. ACKNOWLEDGEMENTS 3.43 3.23 3.74 3.47 3.66 3.44 4.04 3.42 3.6 3.52 3.51 3.55 3.86 3.76 3.65 3.42 0.87 0.9 0.7 0.87 0.73 0.78 0.71 0.8 0.71 0.65 0.67 0.7 0.67 0.67 0.69 0.76 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8 Q9 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Figure 5 : The Perception of Knowledge Towards Preparedness for Disaster Management S2 MEAN S2 SD 3.7 3.32 3.06 3.89 3.48 3.68 3.8 3.78 3.74 3.73 3.79 3.26 3.93 3.7 3.78 3.88 3.48 3.12 3.47 3.65 0.69 0.77 0.92 0.69 0.67 0.7 0.64 0.65 0.65 0.7 0.61 0.71 0.58 0.69 0.62 0.61 0.85 0.81 0.68 0.64 0 0.5 1 1.5 2 2.5 | poster |
TÍTULO: Rompiendo el ciclo: Abordaje integral en la recuperación de trastornos disociativos y dependencia emocional AUTORES: Patricia Gil Delgado1, Sara Mayo González2, Antonia María Nogales Raedo3, Patricia Menéndez Trillo4, Manuela María Rodríguez Rincón5, Andrea Blanco Pericacho6, Laura Andrea Orozco Quiroz7, Miguel Andía Díez8. FILIACIÓN: 1: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 2: Psiquiatra, Médico Adjunto Especialista en Hospital Fuente Bermeja. Complejo Asistencial Universitario de Burgos. 3: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 4: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 5: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 6: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 7: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. 8: Psiquiatra , Médico Interno Residente en Complejo Asistencial Universitario de Burgos. INTRODUCCIÓN Y OBJETIVOS: Los trastornos disociativos y de conversión, frecuentemente asociados a conductas autolesivas y crisis emocionales, pueden generar disfunción progresiva en diversas áreas de la vida del paciente. El manejo terapéutico integral, con enfoque multidisciplinario, es esencial para lograr la estabilización psicopatológica y promover la autonomía. Revisamos, a propósito de un caso, la importancia del abordaje integral en un dispositivo de rehabilitación como medio para la recuperación. | poster |
r.rafia@sheffield.ac.uk Exploratory psychometric analysis of the EQ-5D in a Myelofibrosis population Rachid Rafia, Clara Mukuria, ScHARR, University of Sheffield www.facebook.com/scharrsheffield School Of Health And Related Research INTRODUCTION The EQ-5D is a generic preference-based measure of health-related quality of life (HRQoL) applicable to a wide range of health conditions and treatments.1 Myelofibrosis (MF) is a rare but serious bone-marrow cancer in which the proliferation of an abnormal type of bone marrow stem cell results in fibrosis, or the replacement of the marrow with collagenous connective tissue fibres. Massive spleen enlargement is a consequence of the resulting extra-medullary haematopoiesis and can cause symptoms (typically abdominal pain, early satiety and difficulty in breathing); and can lead to complications such as portal hypertension, splenic infarction and vascular events. Patients commonly have symptoms such as fever, night sweats, and weight loss. There is no evidence about the appropriateness of the EQ-5D in MF; thus, this study aimed to provide psychometric evidence of its appropriateness. • This exploratory analysis suggests that the EQ-5D preference based and health dimensions had poor association with key symptoms in MF, except for the ‘pain/discomfort’ and ‘anxiety/depression’ health dimensions in some respect. • Although the EQ-5D captured some changes, these changes were much smaller than when assessed using the MF-SAF. • This exploratory analysis suggests that the EQ-5D measures’ ability to capture the effect of key symptoms in MF is limited to pain rather than the specific MF symptoms such as night sweat, itchiness. • However, results of this analysis need to be interpreted with caution due to the small number of patients and the potentially non-representative nature of the sample. METHODS The psychometric performance of the EQ-5D was assessed relative to that of a condition-specific measure, the modified MF Symptom Assessment Form (MF-SAF) version 2.0 using data from the ROBUST UK study. The ROBUST UK2 study collected data on both EQ-5D (5 levels) and modified MF-SAF v2.0 in a small sample of UK patients (n=48) with MF, post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia myelofibrosis (PET-MF) with repeated measurement over 48 weeks (baseline, week 4, 12, 24 and 48 weeks). • The EQ-5D (5 levels) classification consists of five dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), each with five levels of response (no problems, slight problems, moderate problems, severe problems, and extreme problems). A single summary score is generated and range from 1 to -0.594 with 1 representing full health and 0 for dead. • The MF-SAF v2.03 has seven symptoms (abdominal discomfort, pain under left ribs, early satiety, night sweats, itching, bone or muscle pain and inactivity) each scored from 0 (absent) to 10 (worst imaginable). A total symptom score (TSS) is generated from the first 6 symptoms. In order for the EQ-5D to be appropriate, the measure should be associated with key symptoms in MF captured by the MF-SAF, at both baseline and over time. Analysis consisted of: • Convergent validity. Convergent validity was assessed by examining how well the EQ-5D preference-based measure and health state classification dimensions were associated with the MF-SAF total score and individual symptoms. Pearson’s correlations were used for continuous variables (e.g preference based and total clinical score); whilst spearman rank correlation was used for dimensions. Correlations were analysed using data at baseline only. The following cut-offs are used to determine the strength of the association: very strong >|0.6|, strong: <|0.6 to ≥ 0.5|, moderate: <|0.5 to ≥ 0.3| and weak:< |0.3|. Given the small sample size, further assessment of convergent validity was undertaken using data from all the time points. To account for repeated measures from t | poster |
Innovative Research for a Sustainable Future www.epa.gov/research Denise MacMillan l macmillan.denise@epa.gov l 919-397-8038 Introduction 5-Day In Vivo Repeat Exposure Study Results Conclusions Non-targeted Analysis for Identification of PFAS Biotransformation Products in Rat Plasma D. K. MacMillan,1 A. Renyer,2 M. DeVito,1 M. F. Hughes,1 and L. C. Wehmas1 1: U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Durham, NC 2: Oak Ridge Institute for Science and Education, Durham, NC Per- and polyfluorinated substances (PFAS) are dispersed throughout the environment due to widespread commercial use, which leads to exposure and the potential for adverse health effects. Toxicological data are available for only a few of the nearly 10,000 currently known PFAS. The USEPA is using short term PFAS exposure studies to: o generate interim risk assessment data for priority chemicals concern to states and EPA Regions, o explore possible biotransformations in mammals, o and further understanding of the biological responses to exposure. Biotransformations of PFAS telomers have been observed in microbes and fish, but few other PFAS or species have been studied. Here we present results of non-targeted analysis (NTA) to identify potential biotransformation products (PBTPs) in plasma from rats exposed over five days to perfluoro(2,5,8-trimethyl-3,6,9-trioxadodecanoic) acid (PF-TODoA), a perfluoroether carboxylic acid oligomer of GenX, and begin to investigate biological response. PF-TODoA dose formulation o Sprague-Dawley, male/female o 8-10 weeks o n=4/sex/dose-level Day 1 2 3 4 5 6 * * * * * X * = Oral gavage. X = Rats euthanized. o Control + 8 Dose-levels o Vehicle = Water o Range: 0.3 – 335.2 mg/kg/day ~1/2 log10 spacing o Plasma (25 µL) prepared by protein precipitation with acidified acetonitrile • Chromatography: Phenomenex Kinetex XB-C18 (100 x 2.1 mm) • A: 95:5 H2O:MeOH and B: 95:5 MeOH:H2O, both containing 4 mM ammonium formate o NTA acquired with Sciex X500R QTOF • Negative ion electrospray ionization (-ESI) • Information Dependent Acquisition (IDA) and Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH) scanning Data processing, library searching (NIST 17, Sciex Fluorochemical, and in-house libraries), formula finding, peak picking and alignment, normalization, and statistical analysis were performed using Sciex OS 2.1.0 and MarkerView 1.3.1. Features were filtered by log fold change, p < 0.05, negative mass defect, and abundance. A screening list of PBTPs was generated using Biotransformer 3.0.1 MetFrag2 was used to generate in-silico spectra of potential candidates. Statistical Analysis NTA data from plasma of male and female rats exposed to 17 mg/kg/day PF-TODoA were normalized and analyzed by supervised principal component analysis (PCA-DA). The scores plot showed separation of the data for exposed samples from study controls. Data from male and female rats clustered apart from controls and distinct from each other. Differences in normalized responses of selected significant ions between groups are Control Male Female 0 -500 D1 Score -1000 500 D2 Score -600 0 600 PF-TODoA CASRN: 65294-16-8 DTXSID70191136 Data were screened for predicted PBTPs. Exact masses observed in MS scans suggested several predicted PBTPs were present, but only the ion of m/z 516.9542 gave an MS/MS spectrum. The fragment ions observed at m/z 350.9 and m/z 184.9 are characteristic of PF-TODoA and consistent with sequential cleavages of C3F6O. An in- silico spectrum generated for PubChem CID 13244841 (ion structure shown) with MetFrag matched all experimental fragment ions. The data suggest O-dealkylation of PF-TODoA to yield an alcohol with the formula C9HF19O3. F F F F F F F F F F F F F F F F F F F F F F F O O O O H O MS/MS of m/z 516.9542 F F F F F F F O – Predicted PBTPs The MS/MS spectrum of the in- source fragment of PF-TODoA, also known as HPFO-TeA, shows character | poster |
Evaluating hyper-resolution global hydrology by comparing spatial and temporal resolutions Jerom Aerts1 (J.P.M.Aerts@tudelft.nl), Rolf Hut1, Nick van de Giesen1, Niels Drost2, Ben van Werkhoven2, Berend Weel2, Inti Pelupessy2, Martine de Vos2, Yifat Dzigan2, Stefan Verhoeven2, Gijs van den Oord2, Ronald van Haren2, Janneke van der Zwaan2 , Maarten van Meersbergen2, Willem van Verseveld3 and Albrecht Weerts3,4 1Delft University of Technology 2Netherlands eScience Center, 3Deltares, 4Wageningen University Global hydrological models have transitioned from global scale to hyper-resolution (5 arc minutes or less). Benefits: • Greater applicability for stakeholders (e.g., comprehensive flood prediction) • Better understanding of hydrological system Challenges1,2,3,5 • Scaling issues that require explicit spatial modelling and parameterized processes • Require lateral connections between compartments of the hydrological system • Increased uncertainty from insufficient parameter data quality Guiding Question How is the hydrological model Wflow SBM impacted by changes in spatiotemporal resolutions? Project Goal Evaluate hyper-resolution global hydrology using the Wflow SBM model4 and the eWaterCycle II platform Why Wflow SBM? • Physically based distributed hydrological model • Can run with any time step • Spatial distribution within the hyper-resolution domain • No calibration required Introduction Intra-Model Comparison Setup Wflow SBM References: 1Beven and Cloke ,2012: Comment on “Hyperresolution global land surface modeling: Meeting a grand challenge for monitoring Earth's terrestrial water” by Eric F. Wood et al. 2Bierkens et al., 2015: Hyper-resolution global hydrological modelling: what is next? 3Melsen et al., 2016: HESS Opinions: The need for process-based evaluation of large-domain hyper-resolution models 4Samaniego et al., 2017: Toward seamless hydrologic predictions across spatial scales 5Wood et al., 2011 : Hyperresolution global land surface modeling: Meeting a grand challenge for monitoring Earth's terrestrial water Going Forward Analyses Input Model Runs Output Streamflow Validation (USGS) and statistics: State Comparison : Total of time series : Total of basin grid cells : Sum of coarse resolution grid cells : Sum of high resolution grid cells Next steps: • Include: soil moisture and snow pack validation, global basin, multiple global hydrological models • Perform benchmark testing • Compare the effect of different precipitation products Share your thoughts on: • Explicit spatial hydrological modelling on high spatial resolutions • Effects of higher temporal resolutions on comparison variables | poster |
Survey responses • Most responses were from Open Science Framework (OSF) supported preprint servers which allow users to link preprints to an OSF project where any output can be recorded. • One (csarven.ca) is a site used by one author for personal preprints. • None have a written policy requiring availability of research data. • The Berkeley Initiative for Transparency in the Social Sciences (BITSS), perhaps unsurprisingly, reports the highest values, along with csarven.ca. • Not all categories were appropriate for all fields and there was a great deal of variation between disciplines. • Only one response disclosed future plans to improve linking options. Submission systems and usage by authors Results for selected preprint servers. Numbers are the % of papers or authors with the given option shown on the abstract page. No number: this option is not available. The submission site for ChinaXiv could not be checked. * indicates that information entered during submission is not displayed directly on the abstract page. • Most older preprint servers (pre-2010) had fewer linking options. • Relatively low use of options from authors was found. Supplementary data files in life sciences were an exception. • No examples of externally linked data or software code were found for the preprints checked. • Humanities and social science servers offer better options for linking to author-specific data, such as websites or social media accounts. Martyn Rittman, Ph.D. Director, Preprints.org; Publishing Services Manager, MDPI AG St Alban-Anlage 66, 4052 Basel, Switzerland rittman@preprints.org, rittman@mdpi.com, @martynrittman Preprints Servers as a Hub for Early-Stage Research Outputs What can preprint servers offer authors and readers? By posting a preprint, authors have the potential to provide a single point of access to all of information relevant to the research project and explain how each part contributes. In other words, preprints can be a focal point for disparate early-stage research outcomes such as data, code, websites, and analysis plans. Linking these outputs can greatly increase transparency and reproducibility, benefiting the wider research community. We investigated the current status of preprints servers to link other outputs (or report as supplementary data), in particular: (i) Which options for linking and reporting are available in submission systems? (ii) What is displayed on preprint abstract pages? (iii) How often do users make use of available features? Information sources 1. Preprint submission systems were checked to see which linking and reporting options are available. 2. Preprints (25 or 50 for selected servers) abstract pages were checked to see if authors make use of available options. 3. Operators of preprint servers were surveyed about linking and reporting options, policies and future plans. Conclusions • Linking and reporting is integrated to some extent in most preprint servers, however linking to external sources is less common. Zenodo is an exception; OSF project linking offer a unique paradigm. • There is variation between disciplines due to the different kinds of early-stage outputs generated. Norms in the field may also be a factor. • Open science is not a primary goal of most preprint servers. If preprints are to be a hub for early-stage reporting, preprint servers need to plan better linking and reporting options and encourage authors to make use of them. What is your overall impression of how often authors use the linking options? | poster |
INTRODUÇÃO OBJETIVOS CONSIDERAÇÕES FINAIS REFERÊNCIAS MÉTODOS O conto “A terceira margem do rio” é um dos 21 contos que faz parte do livro “Primeiras estórias” publicado, em 1962, pelo escritor e médico João Guimarães Rosa. A obra é composta pelos personagens: pai, mãe, filho, irmão e irmã - que não são nomeados. A história é narrada pelo filho que, no decorrer do conto, revela os perfis psicológicos de cada membro da família, o que é importante para compreender o modo como a decisão do pai de construir uma canoa e viver isolado no meio do rio afetou a todos (ROSA, 2001). A Terceira Margem do Rio: O enfrentamento do luto na prática médica JÚLIA L. MATTOS¹, JULIANA A. NASCIMENTO E SILVA ¹, LAURA P. TAVARES¹, MATHEUS DIAS¹ , MARIA JULIA DA S. MENDES¹, MANUELA MARIA A. DE MORAIS E SILVA¹, SAMILY S. FRANÇA¹, ZAIRA NICOLLE F. PEREIRA¹ , RODRIGO RAMON F. GOMEZ² e PROCOPIO M. DOS SANTOS² O presente trabalho tem como finalidade discutir a temática dos assuntos ligados à saúde mental, bem como sua aplicação na prática médica frente a pacientes que estão enfrentando o luto familiar, a partir das reflexões presentes no conto “A Terceira Margem do Rio”. Estudo de caráter qualitativo e interpretativo baseado na análise descritiva do conto “A terceira margem do rio”, de João Guimarães Rosa. Foi realizada busca bibliográfica na base de dados Google Acadêmico, utilizando os descritores “luto familiar”, “morte”, “luto”. RESULTADOS E DISCUSSÃO seus enigmas e o fluir constante das águas que ecoam as complexidades da condição humana. Dessa forma, o isolamento do pai no meio do rio pode ser simbólico do processo de luto, onde uma pessoa enlutada se sente isolada e distante do mundo cotidiano. O rio pode representar o fluxo da vida, e a terceira margem, o espaço entre a vida e a morte. A ausência de uma explicação clara por parte do pai também pode refletir a complexidade e a falta de compreensão muitas vezes associadas ao luto (BUHLER, 2006). Associado ao exposto, a morte está presente de forma constante no contexto de trabalho do profissional de saúde. No entanto, é de essencial importância o preparo emocional desses profissionais na vivência do processo do luto e da morte, além do conhecimento das fases desse processo e das condutas que devem apresentar, tendo em vista a morte com o paciente e a família (COSTA et al, 2005). A narrativa de "A Terceira Margem do Rio" evoca uma sensação de ambiguidade, indicando que o luto não é um processo linear ou facilmente compreensível. Assim como o rio flui, a experiência do luto também pode ser fluida e desafiadora de entendimento. O tema morte é um assunto que as pessoas estão sempre tentando evitar em razão da dificuldade de discutir as suas significações que estão relacionadas com a finitude do ser, pois, o homem tem a probabilidade de evitar temas que lhe provocam angústias e, na tentativa de não sofrer, ele nega a morte, porém não abandona o tormento de sua presença (FREUD, 2011). Ao explorar o curso misterioso do rio e a permanência peculiar do pai na canoa, o autor oferece uma reflexão poética sobre a vida, BUHLER A. As margens do devaneio: uma análise do conto “ A terceira margem do rio”, de João Guimarães Rosa. João Pessoa, v.8, n. 1, jan/jul de 2006. COSTA C., LIMA G. Luto de equipe: Revelações dos profissionais de enfermagem sobre o cuidado à criança/adolescente no processo de morte e morrer, Revista Latino-Americana de Enfermagem, Ribeirão Preto, v. 13, n. 2, mar./abr. 2005. FREUD, S. Luto e melancolia. São Paulo: Cosac Naify, 2011. ROSA, J. A Terceira Margem do Rio. In: Primeiras Estórias. Rio de Janeiro: Nova Fronteira, 2001. Área temática: Reflexão de perda e luto 1 - Acadêmicos do 1º semestre de medicina do UNIEURO. 2 - Professores de Humanidades médicas do UNIEURO. João Guimarães Rosa - A Terceira Margem do Rio | poster |
Expedition 360: SWIR Lower Crust and Moho A. Sanfilippo & R. Tribuzio Dipartimento Scienze Terra e Ambiente, Università di Pavia, Via Ferrata 1, 27100, Pavia, Italy The project “SloMo, The nature of the lower crust and Moho at slower spreading ridges” is a multi- expedition project aimed at drilling the Mohorovičić seismic discontinuity to verify the hypothesis that the Moho corresponds to an ‘alteration front’ 2. IODP Expedition 360 3. Post-cruise meeting (Sicily, Italy) The post-cruise meeting was yield in Siracusa (May 14-17, 2017) partly supported by IODP-Italia where 40 participants preliminary results of post cruise studies and set up long standng colleborations 4. Magmatic processes at the accretion of the lower crust 5. Water-magma interaction Petrological data were combined with in-situ isotopes to discover to what extent magma interacts with and seawater during the cooling and exhumation of this lower crustal sequence 5. Peer-reviewed publications • Ferrando C., Tribuzio R., Lissenberg C.J., France L., MacLeod C.J., Basch V., Villeneuve J., Deloule E., Sanfilippo A. (2022) Brown Amphibole as Tracer of Tectono-Magmatic Evolution of the Atlantis Bank Oceanic Core Complex (IODP Hole U1473A). Journal of Petrology 63 1-27 • Ferrando C., France L., Basch V., Sanfilippo A., Tribuzio R., Boulanger M. (2021) Grain Size Variations Record Segregation of Residual Melts in Slow-Spreading Oceanic Crust (Atlantis Bank, 57°E Southwest Indian Ridge). Journal of Geophysical Research: Solid Earth 126 e2020JB020997 • Boulanger, M; France, L; Ferrando, C; Ildefonse, Benoit; Ghosh, B; Sanfilippo, A; Liu, C‐Z; Morishita, T; Koepke, J; Bruguier, O; (2021). Magma‐Mush Interactions in the Lower Oceanic Crust: Insights From Atlantis Bank Layered Series (Southwest Indian Ridge). Journal of Geophysical Research: Solid Earth, 126, 9, e2021JB022331. • Ferrando, C; Basch. V, Ildefonse. B, Deans, J., Sanfilippo, A; Barou, F., France, L. (2021). Role of compaction in melt extraction and accumulation at a slow spreading center: Microstructures of olivine gabbros from the Atlantis Bank (IODP Hole U1473A, SWIR)",Tectonophysics,815,,229001 • Sanfilippo A., MacLeod C.J., Tribuzio R., Lissenberg C.J., Zanetti A. (2020) Early-Stage Melt-Rock Reaction in a Cooling Crystal Mush Beneath a Slow-Spreading Mid-Ocean Ridge (IODP Hole U1473A, Atlantis Bank, Southwest Indian Ridge). Frontiers in Earth Science 8 579138 • Nozaka T., Akitoua T., Abe N., Tribuzio R. (2019) Biotite in olivine gabbros from Atlantis Bank: Evidence for amphibolite-facies metasomatic alteration of the lower oceanic crust. Lithos 348-349 105176 • Nguyen D., Morishita T., Soda Y., Tamura A., Ghosh B., Harigane Y., France L., Liu CZ, Natland J., Sanfilippo A., MacLeod C., Blum P., Dick H.J.B. (2018). Occurrence of Felsic Rocks in Oceanic Gabbros from IODP Hole U1473A: Implications for Evolved Melt Migration in the Lower Oceanic Crust. Minerals, 8: 583; https://doi.org/10.3390/min8120583 • Dick, H.J.B., MacLeod, C.J., Blum, P., Abe, N., Blackman, D.K., Bowles, J.A., Cheadle, M.J., Cho, K., Ciążela, J., Deans, J.R., Edgcomb, V.P., Ferrando, C., France, L., Ghosh, B., Ildefonse, B., John, B., Kendrick, M.A., Koepke, J.H., Leong, J.A.M., Liu, C., Ma, Q., Morishita, T., Morris, A., Natland, J.H., Nozaka, T., Pluemper, O., Sanfilippo, A., Sylvan, J.B., Tivey, M.A., Tribuzio, R. & Viegas, G., (2019). Dynamic accretion beneath a slow spreading ridge segment: IODP Hole U1473A and the Atlantis Bank Oceanic Core Complex. J. Geophys. Res. Solid Earth. 1. SloMo Project – Leg 1 Microtexture and mineral chemistry showed evidence for process of magma extraction within the studied gabbros From December 2015 to January 2016 the IODP Expedition 360 drilled 800 mbsf of basement rocks at the Atlantis Bank Oceanic Core Complex, Southwest Indian ridge. Hole U1473A respresents thrid longest perforation in the lower oceanic crust, the first in a single leg expedition. Atlantis Bank OCC Petrological studies and detailed | poster |
I-RIM Conference 2019 October 18 - 20, Rome, Italy ISBN: 9788894580501 Towards the Design of Robotic Drivers for Full-Scale Self-Driving Racing Cars Danilo Caporale∗,†, Alessandro Settimi†, Federico Massa†, Luca Bonamini‡, Manuel G. Catalano‡‡, Antonio Bicchi†,‡,‡‡ and Lucia Pallottino†,‡ Abstract— We report on the development of a planning and control framework for an electric full scale autonomous racing car. We describe the whole control system architecture including the mapping and localization methods employed. We also report on novel experimental results obtained within the Roborace Localization challenge, whose first edition took place in Zala Zone1 track in August 2019, related to an informed version of Adaptive Monte Carlo Localization developed for the racing scenario. I. AUTONOMOUS RACING SYSTEMS Challenges are one of the main drives of robotics devel- opment, that call for integration of recent research results in real world applications. In the particular case of self-driving cars, the DARPA Grand Challenge and Urban Challenge have pushed the robotics community to develop autonomous cars meant to drive in unstructured or urban environments. Following the encouraging results of these challenges, car producers have started developing self-driving technologies, which are foreseen to become a disruptive reality in the next decade and possibly the first widespread Artificial Intelligence (AI) applications in robotics. From deploying single vehicles to the consumer market to fleets of shared vehicles to be used as a service, there is a strong interest in the development of level 4 and 5 autonomous behaviors for these cars. Of course, to achieve that, human safety is one of the main concerns. In fact, one of the expected results of the mass adoption of these systems is a sensible reduction of the rate of accidents, especially those due to the errors of human drivers. Despite this being a reasonable outcome, at the moment of writing this paper it is not yet clear where we stand with respect to this goal, and extensive testing would be necessary to confirm that this goal is within reach. In this work, we focus on the particular scenario of a racing track environment, which allows driverless vehicles testing in extreme conditions (high accelerations that trigger the nonlinear behavior of vehicles) without jeopardizing human safety. The interest in this application is justified by the recent creation of racing challenges for full scale (Roborace2), middle scale (Formula SAE3), and small scale ∗Corresponding author: d.caporale@centropiaggio.unipi.it † Centro di Ricerca E. Piaggio - Universit`a di Pisa - Pisa, Italy ‡ Universit`a di Pisa - Pisa, Italy ‡‡ Istituto Italiano di Tecnologia - Genova, Italy 1https://zalazone.hu/en/ 2https://roborace.com/ 3https://www.fsaeonline.com/ Fig. 1. Roborace DevBot during the first Localisation Challenge - Zala Zone (Hungary) 2019. (F1Tenth4) vehicles. Autonomous racing capabilities for non- electric vehicles have been demonstrated but big challenges remain open in improving the self-driving capabilities of full scale electric racing cars. The experimental results we present were obtained on a Roborace’s DevBot, the development version of Robocar (see Fig. 1). The car can be driven either by a human pilot or by an autonomous system. The control architecture of the vehicle is hierarchical and it includes, at low-level, fast response control-loops implemented by the manufacturer, ensuring closed loop control of the actuators and raw input processing from the on-board sensors, while exposing at higher level an open platform for the implementation of user-defined control strategies and perception schemes, see Fig. 2. This key feature first enables rapid development and testing of full-stack autonomous driving control solutions, in which the designer can focus on driverless technology. It also seamlessly allow for the implementation of learning-based approaches in which the human or autonomous driver can | poster |
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov Introduction Methods Conclusions Brett Blackwell l blackwell.brett@epa.gov l 218-529-5078 Empirical measurement of PFAS dosing within in vivo aquatic high throughput assays B. Blackwell1, E. Stacy1, K. Bush2, K. Flynn1, J. Hoang2, M. Le2, D. Villeneuve1 1USEPA Great Lakes Toxicology and Ecology Division, Duluth, MN; 2Oak Ridge Institute for Science and Education (ORISE), Duluth, MN • Understanding per- and polyfluoroalkyl substances (PFAS) toxicity is a priority of the US EPA, and high- throughput testing (HTT) has been developed as a rapid, low-cost alternative to traditional in vivo toxicity testing. • The unique physicochemical properties of PFAS preclude accurately modeling free chemical concentrations using current in vitro disposition models. • Characterizing chemical behavior and partitioning in HTT format is critical for comparison of HTT- derived points of departure with those from traditional aquatic toxicity assays. • Here, 22 individual PFAS (Table 1) were screened for toxicity to juvenile Daphnia magna (see poster 4.21.P-Th175) or Pimephales promelas (poster 2.14.P-We058) following 24 h exposure in 96 well format. • Final concentration of each PFAS in exposure media was empirically measured by LC-MS to accurately assess exposure conditions. Chemical Exposures • PFAS (Table 1) were acquired from EvoTec (South San Francisco, CA) solubilized in DMSO at a nominal concentration of 30 mM and 9.5 mM. Subsequent concentrations were made in a log dilution series from these two solutions for a total of 9 concentrations at ½ log steps. Nominal exposure concentrations ranged 0.03 – 100 μM for each PFAS. • Organisms were exposed to 8 concentrations of each chemical (plus a control) in 1mL polypropylene 96-well plates (n=5 individuals per concentration) in a total volume of 700 µL Lake Superior water spiked with working stock (concentration of DMSO<0.33%). • Working stocks were saved in 1:1 acetonitrile:media or 3:1 acetonitrile:media for chemical analysis. • Exposures were performed for 24 hours at 20 °C (D. magna) or 25°C (P. promelas) with a 16:8 light:dark cycle. Following this, media was transfered from exposure plates into a clean well plate, diluted 1:1 or 3:1 with acetonitrile, and stored at -20°C. • Three replicates per concentration were analyzed for each individual PFAS. For P. promelas, individual replicate wells from one exposure plate were measured while for D. magna, 5 replicate wells per concentration were pooled within 3 replicate exposure plates. The lowest concentration of each PFAS was not measured due to concentrations consistently below or near detection limits (n = 14-21 wells per chemical). Effluent Discharge *Contents of this poster neither constitute, nor necessarily reflect, official US EPA policy. Use or mention of trade names trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government* Chemical Verification • Chemical stocks used to prepare exposure plates and media from post-exposure plates were analyzed by LC-MS using a Vanquish LC system coupled to a TSQ Altis tandem MS. • One method based on EPA Method 1633 (method details given below) was used for quantification of most target analytes. Individual methods were developed for 6:1 FTOH, PFPB, and PFTP. • A stable mass labeled internal standard was used where possible to account for potential matrix effects and analyte loss during sample preparation. • For compounds without a matched internal standard, a stable labeled surrogate with the nearest retention time was used for quantification. Thermo Scientific Vanquish LC system • Column: StableBond C18, 2.1 x 50mm, 1.8μm • Column Temp: 40°C • Injection volume: 5 μL • Mobile phase: A = H2O+5mM ammonium acetate B = MeOH Flow rate: 0.4 mL/min • Gradient: 10% B to 55% B at 2.5 min, to 90% B at 9 min, to 100% B at 9.5 min, held for 2 min, return to 10% B. • Total | poster |
www.nanorigo.eu @EU_NANORIGO www.linkedin.com/groups/12232026 NANORIGO has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the grant agreement No. 814530 Knowledge Readiness Level (KaRL) approach for nanorisk governance and beyond MORE INFORMATION: Project Coordinator: Aarhus University, Janeck James Scott-Fordsmand (jsf@bios.au.dk) Scientific Coordinator: Environmental Assessments, Rudolf Reuther (rudolf.reuther@enas-online.com) Background Regulatory decisions require reliable data and knowledge One form of knowledge is an actionable document Actionable document is a piece of grey literature prepared from operational data of high technical quality, ready to be used for an action (dossiers, public opinions, proposal, meta-analysis, scoping reviews) Usually, actionable documents are prepared by the third party, e.g. consultancies NANORIGO solution – KaRL approach A 9-level scale in analogy to TRL (technology readiness level), the KaRL (Knowledge, Data and Information Readiness Level) allows assessment of knowledge readiness for decision making and provides guidance on how to enhance the readiness level KaRL addresses SEIN principles, circular economy A specialized nanorisk governance council (being in development, NANORIGO) could perform quality check of an actionable document KaRL guarantees traceability of knowledge before its use in decision making transparency Dmitri Ciornii1,* Damjana Drobne2,* Sara Novak2, Eva Kranjc2, Nils Bohmer3, Vasile-Dan Hodoroaba1 1Federal Institute for Materials Research and Testing (BAM), Division 6.1 Surface Analysis and Interfacial Chemistry, 12200 Berlin, Germany 2Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana, Slovenia 3Society for Chemical Engineering and Biotechnology (DECHEMA), Theodor-Heuss-Allee 25, 60486 Frankfurt am Main, Germany E-mail: Dmitri.ciornii@bam.de; Damjana.Drobne@bf.uni-lj.si Challenges in Nanorisk Governance Actionable document‘s quality is argued among stakeholders, consensus on what is reliable document is missing Public is not involved in decision making lack of trust in nanotechnology Decisions on nanorisk are not transparent Inefficient knowledge transfer/sharing, usability Sustainability and circularity are not poperly addressed by policy Fig. 1 KaRL approach in the framework of nanorisk governance Different stakeholders provide data to the specialized nanorisk governance council (NRGC). KaRL1-9 system could be used by NRGC for assessment of data and knowledge readiness. The readiness (maturity) progresses with each level (right hand-side, green boxes): the data, information and knowledge become more reliable and trustful, traceable and ready for the regulatory use. | poster |
DISSEMINATING OPEN SCIENCE: from librarians’ watch to in-house expertise / Originality and strengths The group’s success is based on the diverse background of the participants and the sharing of various skills around open science! A deep knowledge of the needs of the French librarians and communication skills are the key factors of the group • Working and communicating widely to raise awareness on emerging themes and trends • Making surveys and analyzing outputs • Organizing free webinars or workshops, and providing handy reference material dedicated to the community • Delivering concise and accurate information to Higher Education and Research institutions Sharing intelligence to foster negotiations: • Expertise on the French Digital Republic bill, on Text and Data Mining, on Plan S. • The group is working on identifying the terms of each current and future global agreements and trying to elaborate evolving scenarios to determine what would be a successful negotiation. • Given the success of the NegOA group, there are some ongoing reflections about the way to involve data and legal specialists into negotiations / Couperin missions Couperin is a consortium for electronic resources negotiations in France. Couperin missions To build and develop a national network of skills and exchange in the field of electronic resources. To evaluate, negotiate and organize the purchase of digital documentary contents at the best price for its members. Couperin aims to : • Help clarify and develop contractual relations with publishers • Contribute to the development of a French-language digital content offering • Promote access to electronic resources for people with disabilities • Produce and support studies on the use of electronic resources. • Promote national, European and international cooperation in the field of Scientific and Technical Information. • Promote open science Consortium unifié des établissements universitaires et de recherche pour l'accès aux publications numériques CONTACT Jacqueline Gillet jacqueline.gillet@inria.fr Cédric Mercier cedric.mercier@universite-paris-saclay.fr https://gtso.couperin.org / How the group works The group supports the open science community in France. Today OSWG is organized into 4 subgroups: • Research Data Subgroup Its goal is to propose an operational approach to research data management in the context of open science. • Open Access Negotiations Subgroup Its goal is to address the need for a better understanding of the open access components of the negotiations in the context of French research. • Legal SubGroup The group investigates legal issues related to open science. • Interoperability and Networks group The group is working to assess the interoperability issues between the different open science databases, tools and services. digital identity academic visibility databases repositories read and publish agreements advices for negotiators monitor international practice sharing best practices communicate plan s – rss – tdm surveys community resources for researchers tools for research support services training sessions | poster |
Meal Pattern and Obesity Sector for Biostatistics & Repository Data, NIH, MOH among Adolescents in urban area 18.5% 11.3% P-81 ACKNOWLEDGEMENT ACKNOWLEDGEMENT 85% OBESITY CHARACTERICTICS Referrence: Abarca-Gómez L, Abdeen Z.A, Hamid Z.A, Abu-Rmeileh N.M, Acosta-Cazares B, Acuin C, Adams R.J, Aekplakorn W, Afsana K, Aguilar-Salinas C.A. (2017). Worldwide trends in body- mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet, 390: 2627–2642. Appannah G, Pot G.K, Oddy W.H, Jebb S.A, Ambrosini G.L.(2017). Determinants of a dietary pattern linked with greater metabolic risk and its tracking during adolescence. J. Hum. Nutr. Diet. 31, 218–227. Institute for Public Health Institute for Public Health (IPH), National Institutes of Health, Ministry of Health Malaysia. 2018. National Health and Morbidity Survey (NHMS) 2017: Adolescents Health Survey 2017. Yunsheng Ma, Elizabeth R. Bertone,Edward J. Stanek III, et al. Association between eating patterns and obesity in free-living US adult population. American Journal of Epidemiology 2003; Vol. 158, No.1. Bellisle F, McDevitt R, Prentice A. Meal frequency and energy balance. Br J Nutr 1997;77 (supply 1):S57-70.surement studies in 128.9 million children, adolescents, and adults. Lancet, 390: 2627–2642. 1. 2. 3. 4. 5. INTRODUCTION INTRODUCTION Obesity was found to be higher among males and Bumiputera Sarawak. DISCUSSION AND CONCLUSION DISCUSSION AND CONCLUSION This study showed that the prevalence of obesity among Malaysian urban adolescents was quite high with estimating of 1 in every 7 adolescents found to become obese. The study has limitations since it concentrated on the relationship between obesity and food intake effects without taking into account other possible causes. Awareness programmes and activities on obesity and healthy meal pattern need to be improved especially among primary and secondary students. OBESE 15% The prevalence of obesity may have reached a plateau in some developed countries and become more complex and intractable in many developing countries. Poor diet patterns are found to be prospectively associated with an increased risk of adolescent obesity. The aim of this study is to determine the association of having frequent meals towards obesity among Malaysian school-going adolescents in urban areas. 1 2 METHODOLOGY METHODOLOGY This study used the data from National Health Morbidity Survey (NHMS) 2017, a nationwide cross- sectional survey that implemented a two-stage stratified random sampling design. Total of 23,463 adolescent age between 10 to 17 years old from the urban area were involved. Complex samples logistic regression analyses were then performed to estimate the odds of being obese according to the meal type using the SPSS software version 25. Meal patterns are used to describe individuals' eating patterns at a different level of a meal including of breakfast, lunch, dinner, or a smaller-sized meal like supper or snack in a week. 2,103 with male adolescents 187,471 were obese estimated population 1,393 adolescents with f e m a l e 109,990 were obese estimated population Classification table 85%, Nagelkerke R square: 3.3% Others RESULT RESULT Farahdila H, Anita A, Zamtira S, Rozita MY, Azahadi O NMMR-16-698-30042 The author would like to thank the Director of Health Malaysia for permission to present this poster. Appreciation is also dedicated to all individuals who contributed to the success of this study. NOT OBESE 297,462 estimated population of adolescents were o b e s e in urban Malaysia 15% 85% male unadjusted odds ratio 95% ci p-value multivariat adjusted 1.776 1.000 0.942 0.948 0.933 0.963 1.851 1.000 0.973 0.986 0.944 0.949 1.578-1.998 reference p<0.001 0.016 0.344 p<0.001 p<0.001 female breakfast lunch dinner supper 0.942-0.981 0.923-0.974 0.908-0.959 0.943-0.983 p<0.001 odds ratio 95% ci p-value 0.952-0.995 0.957 | poster |
FSC-A SSC-A 0 65536 131072 196608 26214 101 102 103 104 105 Propidium Iodide: Permeabilized Cells Propidium Iodide: Non-permeabilized Cells Abstract Abstract Separation of Epithelial Cell Mixtures Using Fluorescently Labeled Antibodies and Flow Cytometry Cristina E. Stanciu, BS*, Ye Jin Kwon, MS, Sarah R. Ingram, BS, Eduardo E. Bustamante, BS, Jamie Sturgill, PhD, Sarah J. Seashols, PhD, Tracey Dawson Cruz, PhD, Christopher J. Ehrhardt, PhD, Virginia Commonwealth University, Department of Forensic Science, 1015 Floyd Avenue, Rm 2015, Richmond, VA 23284 During this presentation, attendees will be introduced to a novel molecular technique that utilizes fluorescent antibody probes that target antigens within the Major Histocompatability Complex (MHC) on epithelial cell surfaces. Attendees will also learn how antibody hybridization can be coupled to flow cytometry to provide rapid separation of targeted cell populations from a forensic mixture. This research will impact the forensic science community by introducing a high throughput, nondestructive method for generating single source DNA profiles corresponding to each contributor of an epithelial cell mixture. The technique can assist forensic caseworking units by providing an alternative to complex profile interpretation procedures, thereby reducing analytical bottlenecks and loss of evidence. Previous research has shown the application of flow cytometry coupled to antibody probes targeting the Human Leukocyte Antigen system for selectively isolating individual cell populations from a blood mixture to generate single source STR profiles. Our goal with this research was to test this technique against various types of epithelial cell mixtures for resolving individual contributor profiles. Due to its efficacy in earlier studies, we chose an antibody probe complementary to the A*02 allele for all experiments. Hybridization experiments were conducted on both buccal cell mixtures and contact epithelial cell mixtures. Results from buccal cell mixture hybridization showed that this cell type has intrinsically high levels of fluorescence which can interfere with the signal originating from specific probe-antigen interactions on the cell surface. However, detailed statistical analysis of fluorescence histograms did indicate greater shifts in cell fluorescence when donor cell populations were either heterozygous or homozygous for the A02 allele. This suggests that separation of labeled cell populations is still possible even if antibody reactivity is not strictly a function of HLA genotype. In the second experiment, hybridization of the A02 probe was tested against contact epithelial cells. Cells were sampled from the stratum corneum of the epidermal layer from 4 different individuals representing a range of HLA types. Hybridization results showed little to no interaction with the cell surface across all donors tested. This suggests that HLA antibody probes have the potential to resolve complex mixtures containing different sources of epithelial cells (buccal cells from skin) which may aid in the analysis of certain types of forensic cases. Other signatures of epithelial cells have been analyzed by flow cytometry, leading to an enrichment of DNA from one contributor in a mixture. Intrinsic fluorescence intensities of keratinized cells from different donors have been observed in the far red wavelengths, which suggests that environmental factors may affect the autofluorescence of their cells. Shedder status may facilitate mixture separation through area side-scatter and forward-scatter profiles. Corneocytes on the surface of our skin may be more abundant as fragments or as large intact cells, depending on the individual, and their membrane permeability status along with different DNA content may provide new avenues for discriminating contributors in a mixture. Key words: epithelial, mixture, FACS Flow Cytometry: Buccal and Contact Epithelial Cells Flow Cytometry: Buccal and Contact Epithelial | poster |
Information Classification: General Research Citations Building Trust in Wikipedia Kath Burton Survey Design What did the survey reveal about trust in Wikipedia citations? Survey Responses • • • • • • • • • • • • • • • • • Objective Introduction Response analysis • 46% • 28% • 6.7/10 • 4.4% | poster |
Two exceptions: (a) Lottery Tickets (LTs) and, (b) Dynamic Sparse Training (DST). Q: What makes DST and LTs the exceptions? We observe poor gradient flow at initialization and during training - even for LTs! Gradient Flow in Sparse Neural Networks and How Lottery Tickets Win Utku Evci1, Yani Ioannou2, Cem Keskin3, Yann Dauphin1 1Google, 2University of Calgary, 3Meta 1. Motivation: Unstructured Sparse NN Training results in poor generalization 2. Poor Gradient Flow at Init.: We propose a Sparsity-aware Initialization 3. Poor Gradient Flow during Training: DST Improves gradient flow during training 4. Lottery Tickets Relearn the Pruning Solution: LTs are easier to train because they initialized within the same solution basin as the pruned solution, and effectively relearn the pruning solution dense initialization dense solution good pruned solution good pruning mask only (scratch) sparse initialization LT or scratch training ϴt=T ϴt=0 training ϴ0<t≪ T early snapshot LT initialization (revised) LT initialization (original) sparse solution LT: good, scratch: bad MDS Embedding Sparse NN training use dense initialization, but sparse NN have different fan-in/fan-out! Our sparsity-aware initialization accounts for fan-in/fan-out of unstructured sparse neurons giving: (a) better gradient flow at init. and, (b) better generalization a weight mask _ 1 _ _ 2 2 fan in 0 a 0 0 b c b c We investigate LT solns to pruned solns: (a) LTs start close and move towards to the pruning solution. (b) LT solutions are in the same basin as the pruning solutions. (c) high function similarity and poor LT ensemble performance | poster |
For further information visit: http://wedc-knowledge.lboro.ac.uk/ There will be times when it is not feasible to dig a deep pit. For example, when: • the water table is very close to the surface; • it is very difficult to dig more than 1.0 to 1.5 metres below water in a confined space; • there is hard rock close to the surface; and • the ground in which the pit is to be dug is so soft that it keeps collapsing before an adequate depth can be reached. In such circumstances it is often easier to dig two shallow pits than one deep one. The pits are usually connected to the toilet by short pipes that converge at an inspection chamber. The inspection chamber must have an air-tight cover to prevent flies and mosquitoes entering and odours escaping. Twin-pit latrines 1 Using a twin-pit latrine • Before use, the inspection chamber is opened and the outlet to one of the pits is blocked with a large stone or a block of wood. This forces all wastes from the toilet to pass into only one of the pits. • The first pit fills after about two years. The inspection chamber is reopened and the stone or wooden block is moved to cover the pipe leading to the full pit. The inspection chamber is closed again and the latrine returned to use. Wastes will now collect in the second pit. • When the second pit is full, the contents of the first pit will have been standing for at least two years and virtually all of the pathogenic organisms will have died. At this point, it will be safe to remove the pit cover slab and dig out the contents. By this time the pit contents will have broken down to leave an odourless material which can be safely spread on the ground to help improve the quality of soil. • After the first pit has been emptied the cover is replaced, the blockage in the inspection chamber is moved again and the first pit reused. • From then on, a pit is emptied every two years. Side view Handles for both pits and the chamber access cover © WEDC Top view (Distance between pits (a) = width of one pit) (a) (a) (a) Pit 1 (in use) Pit 2 (not in use) Inspection chamber with stone or block of wood for blocking secondary pipe © WEDC For additional information about twin pits refer to Poster 14. Developing knowledge and capacity in water and sanitation POSTER 13 | poster |
Methods This study is using a multiphase mixed methods design. This means that both qualitative methods (such as interviews) and quantitative methods (such as statistical analysis) are being used. The results of the earlier phases will feed into the later phases. Rationale Students frequently find physics difficult and teachers often do not know why. The teacher can give the student all the information they think the student needs and the student still does not understand it. This research project is investigating how students develop an understanding of these particularly tricky physics topics with the aim of producing some useful teaching resources. Students’ ideas about science are complex and interconnected. They often have their own incorrect theories about the way the world works (called ‘alternative conceptions’). A single alternative conception can lead to multiple misconceptions: Findings So Far The interviews with physics teachers for Phase One have been completed and analysed. The tricky physics topics identified for further research in Phase Two are: Electricity, Forces and Radioactivity. Electricity and forces have often been identified by past research as tricky topics for students to learn, but there has not currently been much research into students’ understanding of radioactivity, so this is an interesting finding. Even though teachers from two different schools were interviewed, their students have similar issues and the same misconceptions (such as confusing the nucleus or a plant/animal cell with the nucleus of an atom and thinking an atom has DNA). (Mis)Understanding Physics Katherine Langford, Psychology, FASS What Makes Physics Difficult? Research, including this study, indicates that students often find physics difficult because: Physics concepts (e.g. forces) are often abstract so you cannot see or touch them. Our everyday experiences sometimes conflict with scientific theory. Students frequently struggle with maths, such as equations. Students pick up bad science from everyday sources such as movies or even past teaching. For example, most of us only experience gravity on Earth, so students sometimes think that gravity on other planets must be exactly the same. In fact, gravity is stronger on bigger planets and weaker on smaller ones. Frankenstein Thinking Motivated ReasoningOnce a student has a misconception, it’s really difficult to get rid of it because ofmotivated reasoning.This is when people apply their reasoning in a one-sided manner that supports and rationalises their beliefs while rejecting information that doesn’t fit in with their beliefs.Intelligence is influenced by more than DNA.DNAMotivationHealthEducationUpbringingNutritionThere seems to be a link between students enjoying a subject and them being motivated to learn about it.Note: Having fun is therefore important!!! Lots of people think this character is called Frankenstein, but it’s actually Frankenstein’s monster. A lot of research just lists students’ misconceptions, which isn’t enough. We need to look for the causes of misconceptions. Teachers and researchers often assumme that misconceptions like this are easy to fix by simply giving students the correct information, but it often doesn’t work like this with science as students simply reject what their teachers tell them. Dr Frankenstein is the one who created the monster. Refusing to believe in climate change despite the scientific evidence is a good example of motivated reasoning. Scientists are also more likely to accept results which fit in with their own beliefs.EXAMPLES How do Secondary School Students Develop an Understanding of Tricky Physics Topics? | poster |
Xiaomin Ye1,2*, Jianqiang Liu1,2, Mingsen Lin1,2 , Bin Zou1,2, Jing Ding1,2 , Qingjun Song1,2, Yue Teng1,2 1National Satellite Ocean Application Service, Ministry of Natural Resources, Beijing, China; 2Key Laboratory of Space Ocean Remote Sensing and Application, MNR, Beijing, China *E-mail: yexiaomin2011@foxmail.com；ORCID: 0000-0003-1044-0125 Introduction of HY-1C and HY-1D satellites The Chinese Haiyang-1C (HY-1C) and Haiyang-1D (HY-1D) satellites, the follow-on mission to the HY-1A and HY- 1B satellites, was launched in September 2018 and June 2020, respectively. This satellites are both equipped with the COCTS and a coastal zone imager (CZI), as well as an ultraviolet imager (UVI), a satellite calibration spectrometer (SCS) and a satellite-based automatic identification system (AIS) receiver. The orbit altitude and tilting angle are 782 km and 98.5 degrees, respectively. The overpass times are10:30 AM±30 min local time at the descending node for HY-1C and are 1:30 PM±30 min local time at the ascending node for HY-1D, respectively. The joint observations of HY-1C and HY-1D increase the observation time and improve the global coverage. The COCTS instruments on the two satellites can detect the global ocean and land four times every day and provide daily ocean color and daytime and nighttime SST data. The COCTS is a moderate-resolution imaging scanner with a nadir spatial resolution of 1.1 km and a viewing swath width of more than 2900 km. The satellite measures signals in 8 visible and near-infrared (VNIR) bands and 2 thermal infrared (TIR) bands (10.3~11.3μm，11.5~12.5μm). Evaluation of sea surface temperatures derived from the HY-1C and HY-1D satellites Global SST have been detecting by the COCTS instruments since September 2018. The BTs (Level-1 data) and SST products (Level-2 and Level-3 data) of SST can be distributed to public for free. Examples of data products are shown in Fig.1 to Fig.4. Level-3 SST data are the gridded products with a grid resolution of 4 km and 9 km(see Fig.4). Fig.1 Global quasi true-color image from COCTS on HY-1C (acquired on October 8, 2019) A nonlinear SST algorithm (NLSST) is applied to derive SSTs from the brightness temperatures (BTs) of the two COCTS thermal infrared bands at 10.8 and 12.0 μm. The SST retrieval results from the multichannel SST algorithm (MCSST) are used as the first guess for the input of the NLSST algorithm. The coefficients of both the MCSST and NLSST algorithms are regressed from the matchup datasets of the COCTS BT observations and the measurements from the in situ Quality Monitor system (iQuam). The algorithm coefficients of HY-1C and HY-1D can be found in Ye et al (2021) and Ye et al (2022). ___________________________________ Acknowledgements The authors would like to thank the NASA Goddard Space Flight Center, Ocean Ecology Laboratory, and Ocean Biology Processing Group (OBPG) for providing access to the MODIS and VIIRS SST data, as well as the Center for STAR and NOAA National Environmental Satellite, Data, and Information Service (NESDIS) for providing access to the in situ iQuam data for validation in our study. References [1] X. Ye,, J. Liu, M. Lin, J. Ding, B. Zou，Q. Song, and Y. Teng, "Evaluation of Sea Surface Temperatures Derived From the HY-1D Satellite," in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, vol. 15, pp. 654-665, 2022, DOI: 10.1109/JSTARS.2021.3137230. [2] X. Ye, J. Liu, M. Lin, J. Ding, B. Zou and Q. Song, "Sea Surface Temperatures Derived From COCTS Onboard the HY-1C Satellite," in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, vol. 14, pp. 1038-1047, 2021, DOI: 10.1109/JSTARS.2020.3033317. Fig.4 (a) Daily gridded nighttime SST of HY-1C satellite on October 8, 2019 and (b) Monthly gridded daytime SST of HY-1D satellite in June 2021. Fig5. Validation results of SST from COCTS against in situ measurements from iQuam during (a) daytime and (b) nighttime in the period from Ja | poster |
Neutrino Energy Estimation Techniques in NOvA Nitish Nayak University of California, Irvine (For the NOvA Collaboration) 2. Detection Principle • Upgraded NuMI muon neutrino beam at Fermilab (700 kW design) • Longest baseline in operation (810 km), large matter effect (±30%), sensitive to mass hierarchy • Far/Near detector sited 14 mrad off-axis, narrow-band beam around oscillation maximum 1. NuMI Off-Axis νe Appearance Experiment [2]. P. Baldi, J. Bian, L. Hertel, L. Li Phys. Rev. D 99, 012011 • Tracking Calorimeter with Low-Z scintillator (mineral oil- based) • Finely segmented • Good separation • Radiation Length ~ 6 cell depths -> Good energy resolution WLS Fiber Readout at APDs CC νµ CC νe NC e−/µ−/⇡0 3. νe Energy Reconstruction • Identify EM and hadronic clusters using a context-enriched CNN [1] • Takes into account e/h detector response 5. νµ Energy Reconstruction • Muon hits grouped by a kalman tracking algorithm • Energy highly correlated with track length, resolution ~ 3% • Hadronic energy estimated from visible hadronic activity using a spline-based fit • Includes hadronic activity overlapping with muon track • Takes into account different regions of phase space in the underlying interaction model • Energy resolution ~ 26% • E(νµ) = Emuon + Ehadron with overall resolution ~ 6% 0 5 10 15 20 Reco Muon Track Length (m) 0 1 2 3 4 5 True Muon Energy (GeV) 2 − 10 1 − 10 1 NOvA Simulation Neutrino Beam 0 0.5 1 1.5 2 Visible Hadronic E (GeV) 0 1 2 3 4 5 True Neutrino E - Reco Muon E (GeV) 2 − 10 1 − 10 1 NOvA Simulation Neutrino Beam • Individual calorimetric energies are fit to true neutrino energy • E(νe) = A*EEM + B*EHAD + C*EEM 2 + D*EHAD2 • Helps to keep resolution bias flat vs true energy • Overall neutrino energy resolution ~ 11% 4. νe Energy - Further Improvements • Use images of the νe CC interaction directly and feed it into a regression based CNN • Minimal reconstruction dependence • Flattened input true neutrino energy distribution to control bias • Significantly better performance! [2] • Better control over systematic uncertainties 6. νµ Energy - Further Improvements • Tracking is more relevant for muons than calorimetry • Makes more sense to use physics- related reconstructed quantities as input • Feed track lengths, track energies etc into a LSTM-based RNN • Useful when number of inputs not known apriori • Similar unbiased training yields very promising improvements too! [1]. F. Psihas, E. Niner, M. Groh et al. Phys. Rev. D 100, 073005 A. Back, M. Groh - ML applications in NOvA (Poster) sequential output sequential input | poster |
Mass-spectrometry data analysis & web-platform development. Interplay between proteins and disease states. New tools I’m interested in: | poster |
Als Linked Open Data wird die direkte Vernetzung von frei verfügba ren Daten im Internet bezeichnet. Aufgrund der ständig wachsenden Datenmenge ergeben sich für die Wissenschaften daraus ganz neue Erkenntnismöglichkeiten. Dieses Wissensnetzwerk kämpft unter anderem mit dem Problem von nicht eindeutigen Begrifflichkeiten. Der natürliche Wortlaut ei nes Begriffs genügt datenverarbeitenden Systemen oftmals nicht, um sich dessen exakte Bedeutung zu erschließen. Eine maschinen lesbare Definition beinhaltet daher neben natürlichsprachlicher Er läuterungen auch Verknüpfungen zu anderen Datenquellen, um den korrekten Begriffskontext sicherzustellen. Labeling System ist eine Web-App, die an dieser Stelle ansetzt und mittels einer leicht bedienbaren Nutzeroberfläche das Erstellen von Begriffen und deren maschinenlesbarer Definitionen ermöglicht. Wissenschaftler*innen haben so die Möglichkeit, ihr Wissen als ”Lin ked Open Data“ zur Verfügung zu stellen und somit die Qualität der Forschungsdaten in ihrem Arbeitsgebiet zu verbessern. labeling system #Linked Data #Web-App #Usability #Publizieren im Netz #Metadaten Florian Thiery Axel Kunz Matthias Dufner Features • Leicht zu bedienender Web-Editor • Suchfunktion für Referenzthesauri wie Getty oder Wikidata • Erstellen, Definieren, Bearbeiten und Publizieren von digitalen Begriffen • Offener Zugriff auf das erstellte Wissens netz Hochschule Mainz – University of Applied Sciences – Lucy-Hillebrand-Straße 2 –55128 Mainz – mainzed.org Mainzer Zentrum für Digitalität in den Geistes- und Kulturwissenschaften | poster |
Fig.4 Botryosphaeria dothidea cultivated on MEA medium. Growth of the mycelium after 5 days (a), 10 days (b) and 1 month (c) Barbora Zelinková - zelinkobar@natur.cuni.cz 1 - P. schultei 2 - A. echii 3 - L. arundinis (B) 4 - L. arundinis (A) 5 - L. arundinis (C) 6 - L. artemisiiae 7 - B. reticulatus . Fig.5 * PYSZKO, Petr, Hana ŠIGUTOVÁ, Miroslav KOLAŘÍK, Martin KOSTOVČÍK, Jan ŠEVČÍÍ K, Martin ŠIGUT, Denisa VIŠŇOVSKÁ and Pavel DROZD, 2024. Mycobiomes of two distinct cla des of ambro sia g all mid ges (Dipte ra: Cecidomyiid ae) are species-speci fic in lar vae but simi la r in nutritive mycelia. Microbiology Spectrum [online]. Available at: doi:10.1128/spectrum.02830-23 a b c Ambrosia gall midges (AGMs) are specialized Dipteran insects known for inducing galls, mostly on specific kind of host plants. These galls serve as intricate habitats where AGMs cultivate fungal symbionts in an ambrosia layer, a probable source of their nutrition. Additionally, AGMs may engage in phytomycetophagy, a unique feeding behaviour involving the consumption both of plant biomass and mycelium. The most commonly identified fungal species from mycelial layer is Botryosphaeria dothidea (Ascomycota: Dothideomycetes), which is known as a worldwide endophytic and pathogenic species threatening agricultural crops - currently Vitis vinifera. However, despite its frequent occurrence, B. dothidea has not been the subject of many studies on the significance of its secondary metabolites and their effect on the host plant, the insect larvae, or their possible involvement in gall initiation. Fig.1 - Asphondylia sarothamni on Cytisus Fig.2 - Opened gall of Asphondylia echii with pupa on Echium vulgare Fig.3 - Different stages of B. dothidea Fig.4 - Mycobiomes - Pyszko et al. (2024)* Fig.5 - Stable isotope compositions (preliminary data) To gain a better understanding of the interactions between fungi, larvae, and host plants, our next steps include determining the diversity and taxonomy of gall symbionts using metabarcoding (ITS for fungi, 16S for bacteria) followed by multilocus approach (TUB2, TEF1a) for problematic taxa. We will also explore the secondary metabolites, particularly those produced by Botryosphaeria dothidea, and their role in gall formation, insect development, and coexistence with other symbiotic fungi. Research on gall-associated fungi has primarily relied on cultivation methods, often neglecting potential larval endosymbionts. We used ITS2 rRNA metabarcoding to analyse the mycobiomes within different gall compartments (gall surface, gall interior, and larva) across six species from two phylogenetically distinct tribes (Asphondyliini and Lasiopterini) - Fig.4. The mycobiome of the gall interior was primarily dominated by Botryosphaeria dothidea (except in Lasioptera arundinis), confirming the long-standing hypothesis of its significant evolutionary association with AGMs. Feeding strategy of young Cecidomyiidaes is unknown for each particular species. The stable isotope compositions of carbon-13 (δ^13C) and nitrogen-15 (δ^15N) in Cecidomyiidae larvae (Asphondylia echii, Lasioptera artemisiiae, and Lasioptera arundinis) compared with those of strict phytophagous (Peruphasma schultei) and strict mycophagous (Bolitophagus reticulatus) species (Fig.5) distingues if their diet is leaning closer to phytophagous or mycophagous. ¹ Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic ² Department of Zoology, Faculty of Science, Palacký University, Olomouc, Czech Republic ³ Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic Fig.1 Fig.3 Petr Pyszko¹, Hana Šigutová¹'², Miroslav Kolařík³, Martin Kostovčík³, Jan Ševčík¹, Martin Šigut¹'³, Denisa Višňovská¹'³, Pavel Drozd¹, Eva Stodůlková³, Lenka Machová³, Barbora Zelinková³ Sincere thanks to the Czech Science Fund (GA23-07026S) for funding this project and Strategie AV21 project “VP33 MycoLife – the world of fungi” of | poster |
GATE-Time: Extraction of Temporal Expressions -and Events! Leon Derczynski Jannik Strötgen Diana Maynard Mark A. Greenwood Manuel Jung Time is critical to language • required to discuss past events, change, or plans • most information bounded in time: the sky isn’t always blue, George W Bush did not reign forever TimeML is an ISO standard for annotating time in language GATE is an established NLP platform We annotate time in language using GATE and following TimeML Temporal expressions are things like dates, times, and durations We find these using HeidelTime It marks up the times in the text .. e.g. “Can we reschedule for the Tuesday after next please” .. and links them to a calendar. We find events by upgrading an older system (Evita) The SVM/UM learns to find event words by exploiting the fact that most words aren’t events This gives us fast, flexible, state of the art performance Also, because GATE applications are modular, other Applications can be added * TIMEN * TimeNorm * Temporal co-reference GATE-Time is an open, modular, and supported tool for temporal information processing. Use it! PHEME | poster |
Workflow of sequential rotor blade fatigue test and post-fatigue static test procedure — Full scale Fatigue tests are an important part in the certification process of new wind turbine rotor blade designs. As the blades are designed longer and closer to material limits, the fatigue tests are more time-consuming, and high overloading is more critical. By splitting the fatigue test into multiple test sequences on specific sections of the blade and accumulating the fatigue damage, the overloading can be reduced drastically, and a lot of time can be saved. Introduction Modern wind turbines have a higher rated power and longer more slender rotor blades compared to earlier designs. Thus, facilities performing full scale blade tests for certification need to be upgraded for static and fatigue testing to introduce larger loads and deal with larger tip deflections. Also, the test methods need to be adapted to avoid high overloads and reduce testing time. The most time-consuming part of the test campaign is the fatigue testing according to the current standards [1]. To introduce a damage equivalent load of a lifetime of 20-25 years rotor blades are subjected to cyclic loading with resonant excitation. Due to the lower natural frequencies of larger blades the conventional fatigue tests take even longer. Also, to sufficiently test the whole region of interest, high local overloads must often be accepted, possibly leading to premature damages, which need to be repaired mid-test. To reduce the peak loads, higher cycle numbers are required further prolonging the test. By cutting the blade into two segments (root and tip) and testing both segments simultaneously at higher natural frequencies as described by Ha et al. [2], the test duration can be reduced, but the mid-section around the cutting position cannot be tested sufficiently, which could also be overcome by using overlapping segments from two rotor blades. However, here an alternative method is proposed requiring only one rotor blade. Methodology In the proposed approach called “sequential testing”, the damage is introduced by multiple tests, each of which contributes to the resulting fatigue damage by linear damage accumulation. In the first test, the whole blade is tested with a similar setup as during a conventional test. The root and tip areas are not fully tested during the first test, which reduces the overloading in higher loaded areas. then the blade is cut into two (or more) segments, which are then tested simultaneously in separate test setups, at higher frequencies to accelerate the overall test. These setups are chosen to introduce the remaining fatigue damage in the previously undertested areas of the blade. The fatigue damage of all tests is accumulated to achieve the target damage in the whole region of interest, while drastically reducing overloads compared to conventional tests. The resulting reduction in local peak load allows for a higher load level overall reducing the required load cycles and therefore the testing time. The post-fatigue static tests also need to be executed in separate tests for each target region as shown in the workflow figure (left). The different test setups need to be attuned to one another. To find a good set of suitable test setups, including cutting position, additional masses and excitation, a numeric optimization is required. This was done based on a FE-Beam model and the simulation method by Melcher et al [3]. Furthermore, a quality measure for damage conformity was introduced. See the full paper for further details. Example As it is generally more difficult to reduce overloading in lead-lag fatigue testing than in flapwise fatigue testing, the proposed method is applied here by way of example to the lead-lag test of a current offshore rotor blade design of over 110 m in length with a region of interest between 7% and 90% blade length. A set of setups for sequential testing and a conventional test setup for comparison were designed | poster |
Acknowledgements: Contact email: schakdar@holycross.edu This research work is supported by the College of the Holy Cross’s Bachelor Ford Summer Fellowship 2020 References: 1. P.Q Hung, Phys. Lett. B649 (2007) 275279, arXiv: 0612004 2. S. Chakdar, K. Ghosh, V. Hoang, P. Q. Hung and S. Nandi, Phys. Rev. D95 no. 1, (2017) 015014, arXiv:1606.08502 3. S. Chakdar, K. Ghosh, V. Hoang, P.Q Hung and S. Nandi, Phys.Rev.D 93 (2016) 3, 035007, arXiv: 1508.07318 Particle Content Prospect of singlet scalar DM candidate in the EW scale-!" model Shreyashi Chakdar1, Dilip Ghosh2, P. Q. Hung 3, and Najimuddin Khan2, 1 College of the Holy Cross, 2Indian Association for the Cultivation of Science, 3University of Virginia Neutrino mass is the only evidence of BSM Physics so far! • Neutrino (ν) masses → popular “Seesaw mechanism” • In general Seesaw Mechanism: #$ →&' 2 )×' 1 , singlet • RH neutrino mass at GUT scale! NOT directly testable at LHC • Stand scenes: L-R : mD ~ Λ EW , MR ~MWR , GUT: MR ~ Λ GUT #$’s are Sterile in standard scenarios • What if MR ~ Λ EW? Can #$ ’s be non-sterile? Solution: • SM + Mirror Fermions + extended scalar sector Gauge Group : SU(3)c x SU(2)W x U(1)Y • . = 0 12 3 14 3 5678 92= 1 (custodial global symmetry SU(2)) • #1~ : (Λ=>) →A “large” triplet vev spoils . = 1 at Tree level • To restore the Custodial symmetry, a triplet Higgs scalar @ = (3, , 8 = 0) is added to the scalar sector such that • The Higgs potential has a global &' 2 ) × &' 2 $ symmetry →&' 2 D • The nature of EW symmetry breaking is intrinsically linked to Majorana mass of the non-sterile RH E • Physical scalars are grouped into Custodial SU(2)D states: 18 physical scalars grouped 5 + 3 + 3 + 3 + 3 + 1 Quintet →FG ±±, FG ±, FG I Triplet →FJ ±, FJ I, F′J ±, F′J I, F1 ±, F1 I , F1 L±, F1 LI Real Singlet →FM I, F′M I, FM1 I , FM1 LI , FMI, FM NI Complex Singlet →ON I Singlet States: Vev’s satisfy: • 6 mass eigenstates are denoted by P FQ, P F, RF’, RF’’, RF’’’, RF’’’’ • P FN →lightest (DM), next heavier ones are RF’, RF’’, RF’’’, with heaviest state RF’’’’ and RF →125 GeV • The pseudo singlet scalar is the DM candidate (Mev-GeV mass range) • The main contribution to the DM effective annihilation cross-section comes from annihilation channel ONI ONI →SM SM, (diagrams below) • Relic density related to annihilation cross-section and decay lifetime • Framework has Majorana and new mirror fermion masses within the reach of the current colliders • Complete scalar sector spectrum including heavier triplets, doublets and singlet Higgs states in conjunction with the current 125-GeV LHC data is analyzed • Prospect of the singlet scalar fulfilling the role of the DM candidate is investigated wrt the current bounds • EWE$ scenario links neutrino mass, DM studies and Long-lived Particles (LLP) searches at the Collider Extended Scalar sector Singlet Scalar • ONI = \∅NI^ , the complex singlet is investigated to be DM candidate in this analysis • At tree level, the mass of the complex singlet scalar ON I= \∅N I^ is given by • In gen, RFNI, F8 I, FM1 I , F81 I , FNI and FM I_ components can mix through • Two doublets in each sector, coupling to up and down components • Yukawa part of the Lagrangian is given by: Benchmark Points and experimental data Summary Dark Matter Model and Framework TABLE I: Branching Ratios for SM-like Higgs (`a ~ 125 GeV) decaying through various SM and BSM channels for a model Benchmark Point TABLE II: Signal Strengths for the Higgs-like Boson for the benchmark point examined in Table I MAs 0 <Mh/2 3 band in DMh2=0.1198±0.0026 MAs 0= 85 c (v1 + v2) (v1 M + v2 M) 1 0 As 0As 0 coupling: 4 a v1+2 5 c (v1 M+v2 M) 2 0 As 0As 0 coupling: 4 a v1+2 5 c (v1 M+v2 M) Allowed from Direct detection (Xenon 1T) 20 50 100 200 500 10-4 0.01 1 100 Mass of the Dark Matter MAs 0 (GeV) As 0h2 Fig: Plot shows variation of relic density (Ωℎ8) vs Dark matter mass. The red line signifies bounds coming from the recent direct detection xenon 1T data. The blue band | poster |
Shifting Terms and Concepts: From Defence to (Human) Security Introduction Over the last two decades, the concepts of defence and security have overlapped to the point where the former is merged with the latter. Since jihadist terrorism broke out at the dawn of the millennium, governments have been forced to review the classic paradigm according to which the military is employed in overseas operations—or the defence of the homeland from external enemies—and police and law enforcement agencies are tasked with internal security. In such a context, the military has taken on an increasing role in national security matters, although security itself is an umbrella concept under development that currently includes such cross- cutting topics as terrorism, cyber threats, health, food, energy, the economy, poverty, climate change, information technology, social security, job security, just to mention a few. The inclination to replace the idea of defence with security has contributed to the expansion of the idea of security itself. This way, defence activities abroad, such as military assistance to Ukraine in the context of the ongoing conflict with Russia, are presented to the public as "security" operations. Data analysis The author of this work has checked the multi-sectoral approach to security outlined by the UN and the NATO against commonly accepted versions of human security through a comparative study of the definitions provided by well-established and reputable dictionaries such as Merriam-Webster, Britannica, Collins, Oxford, Cambridge, Longman, and Macmillan. Such dictionaries provide similar definitions of the term "security": safety; safety from attack, harm, or damage; freedom from danger or threat; freedom from fear or anxiety; being safe and free from worry; being protected or safe from harm. Security is the protection from, or resilience against, the potential harm caused by others by restricting one's freedom to act. Conclusions The human security approach broadens the scope of security analysis and policy from the traditional notion of national security to the security of people and their complex social and economic interactions. The term "defence", is given as a synonym of "security" by the majority of these dictionaries (Merriam-Webster, Cambridge, Oxford, Collins), even though Britannica and Macmillan continue to be anchored to the dichotomy of defence/external and security/internal, respectively, by providing the words "national security" and "internal security", is evidence of this trend. The evolving concept of security must be scrutinised, with special attention paid to the notion of human security, boosted by UN General Assembly resolution 66/290 and the NATO Strategic Concept 2022, and currently under investigation by the Exploratory Team of the NATO Science and Technology Organization. So far, the meaning of “human security” remains unclear. References 1. United Nations Development Programme (UNDP), Human Development Report 1994: New Dimensions of Human Security, New York, UN, 1994. 2. UN General Assembly (UNGA), Follow-up to paragraph 143 on human security of the 2005 World Summit Outcome, resolution adopted on 25 Oct. 2012, A/RES/66/290, in GAOR, 66th sess., Suppl. no. 49. 3. NATO Heads of State and Government, Warsaw Summit Communiqué, 9 July 2016, Press Release (2016) 100. 4. NATO Heads of State and Government, London Declaration, 4 dec. 2019, Press Release (2019) 115. 5. NATO Heads of State and Government, Brussels Summit Communiqué, 14 June 2021, Press Release (2021) 086. 6. NATO Heads of State and Government, Madrid Summit Declaration, 29 June 2022, Press Release (2022) 095. 7. NATO Strategic Concept 2022, adopted at the Madrid Summit, 28-29 June 2022. 8. NATO, Human Security: Approach and Guiding Principles, https://www.nato.int/cps/en/natohq/official_texts_208515.htm?s electedLocale=en. 9. Marsili, Marco, The Role of the Armed Forces in Homeland Security, in Book of Abstracts of the XI Portuguese Con | poster |
Current Work Contribution Role Ontology (CRO) The CRO, shown in the diagram at the right, was developed by the FORCE11 Attribution Working Group. This ontology extends the publication author roles in the Contributor Role Taxonomy (CRediT) based on an in-depth investigation of activities and outputs and requirements evaluation, in order to create a contributorship model that not only covers a diversity of contribution types beyond publications, but also covers a variety of research fields and is specific enough to meaningfully describe contribution. https://github.com/openrif/contribution-ontology SciENcv Alignment This work aims to align the US Federal Science Experts Network Curriculum Vitae XML Schema, which is used to create biographical sketches for federal funding applications, with the VIVO-ISF ontology. Goals include expanding the role of SciENcv in data exchange, widening the set of data sources used in research profiling analytics, and broadening the definition of researcher impact by facilitating the emergence of new standards relating to the contribution and attribution of researchers to a variety of scholarly products. This work is supported by NIH/NCATS Award 3 UL1 TR000128-10S1. https://github.com/openrif/sciencv-integration VIVO for Historical Persons (VIVO4HP) VIVO4HP is a project to extend the VIVO-ISF ontology to accommodate historical persons, using early Stuart diplomats. Current extensions address modeling diplomatic missions and historical dates. https://github.com/openrif/vivo4hp Who we are and what we contribute: The Open Research Information Framework as a means to understand scholarship Marijane White1, Shahim Essaid1, Matthew Brush1, Karen Gutzman3, Alexandre Rademaker4, Tenille Johnson5, Muhammad Javed6, Jon Corson-Rikert6, George Chacko7, Mike Conlon8, Alex Viggo9, Thea Lindquist9, Kristi Holmes3, Melissa Haendel1,3, Violeta Ilik3 1Ontology Development Group, Library, 2Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR; 3Galter Health Sciences Library, Northwestern University, Chicago, IL; 4IBM Research, Rio de Janerio, Brazil; 5Harvard Medical School, Boston, MA; 6Cornell University, Ithaca, NY; 7NET Esolutions Corporation, McLean, VA;8Duraspace, 9University of Colorado Boulder, Boulder, CO Follow Us! @OpenRIF http://www.openrif.org openrif-community@googlegroups.com Contribute! http://www.github.com/openrif openrif-dev@googlegroups.com What OpenRIF OpenRIF, the Open Research Information Framework, is an open source community devoted to representing the expertise ecosystem — all the things we do and all the things we contribute — by developing and promoting interoperable and extensible semantic infrastructure. Semantic Frameworks • VIVO Integrated Semantic Framework (VIVO-ISF), which represents people, works, and the relationships between them • Federated databases modeled on PARDI, the Portfolio Analysis and Reporting Data Infrastructure, for research impact and evaluation • eagle-i, which aims to make discoverable research resources and their relationships to scholarly activities. Alignment Opportunities OpenRIF seeks to align with other knowledge representation efforts: Future Work Implement Ontology Change Management • Formalize process for versioned ontology changes • Learn from the success of the Schema.org community Modularize the VIVO-ISF Ontology • Create external ontology modules • Create sub-graph ontology modules • Allow VIVO instances to use only the ontology they need Develop New Modules Research Outputs Ontology Academic Degrees Taxonomy Grants Taxonomy Expand Domain Coverage Beyond academic research and scholarship: • Industry Research • Open Source Software Contributions Align with Schema.org • Facilitate Search Engine Optimization (SEO) for web applications using VIVO-ISF Join the OBO Foundry Library • Increase exposure and usage of VIVO-ISF OpenRIF: Representing Expertise Ecosystems Why • Improve academic reporting by | poster |
Syntheঞc Natural Xenobiology Syntheঞc Biology Geneঞc Firewall Classic Gene Technology Alternaঞve Genomes Refactored Genomes Syntheঞc Genomes Syntheঞc Alleles Transgenic Variants Directed Mutaঞons Random Mutaঞons Natural Isolaঞons | poster |
CARTE: Pretraining and Transfer for Tabular Learning Myung Jun Kim, Léo Grinsztajn, Gaël Varoquaux Pretrain Models for Tabular Learning Context-Aware Representation of Table Entries Schema Matching Not Required for CARTE Key Ingredients from CARTE GitHub Datasets Paper ▪Generalization of table entries with graph representation ✓No schema or entity matching across tables ▪Pretrain from large knowledgebases (knowledge graphs) ✓Train over 18.1 million triplets of 6.3 million entities in YAGO ▪Graph-attentional network that leverage context in tabular data Three key components of CARTE: Background information to downstream tasks Finetuning Strategies of CARTE CARTE Markedly Outperforms the Alternatives Entity Matching Not Required for CARTE More than LLMs: modeling numbers Toward tabular foundation models [Graph Representation] [Pretrain] [Graph-Attentional Network] ▪Finetune CARTE for single-tables and multi-tables ▪Bagging strategy on train/validation splits ▪Limit the number of layers 51 datasets representative of modern data science applications [Regression] [Classification] Extensive comparison over 42 baselines for tabular learning Preprocessing Methods TableVectorizer (TabVec) Target Encoder (TarEnc) Sentence-LLM (S-LLM) FastText Embeddings (FT) LLM Embeddings (LLM) Estimators CARTE CatBoost XGBoost (XGB) HistGradBoosting (HGB) RandomForests (RF) Linear (Ridge / Logistic) NN Models (ResNet / MLP) TabPFN Abundant but heterogenous tabular data ▪Manual entity matching of the entries to their corresponding YAGO entity ▪Knowledge graph embeddings (KEN) require entity matching to have good performance ▪CARTE is robust to entity variants Results over four datasets with manual entity matching: ▪Tables with meaningful columns and discrete entries Groups covering the same general topic but from different sources ▪12 topics - 125 cases for two-tables and 245 cases for multiple-tables [Comparison on Two-Tables] [CARTE Across Multiple-Tables] CARTE provides consistent improvements without column matching CARTE further benefits from additional source tables Performance boosting architecture ① “George Bush”? 41st or 43rd president? ② ‘Term’ and ‘Incumbency’ are they same columns? ③ ‘London’ and ‘Londres ’ are they same entities? Ambiguity in schema and entity resolution Different table specifications ✓Number of columns, inference tasks Out of vocabularies | poster |
All Errors Are not the Same: Different Memory Profiles between Aging, Alzheimer's Disease and Semantic Dementia from a New Memory Test G.T. Vallet1,2, M. Simard2,4, J. Macoir3,4, C. Hudon2,4, N. Bier5,6, & R. Versace1 1 Laboratoire EMC, Lyon 2 University, Lyon, France 4 CRUSMQ, Quebec City, Canada 2 School of Psychology, Laval University, Quebec City, Canada 5 École de Réadaptation, Université de Montréal, Montréal, Canada 3 Département de Réadaptation, Université Laval, Quebec City, Canada 6 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada Memory Group Age Education Gender (M/F) MMSE (/30) Young (n=55) 24 (3.7) 16 (2.6) 15/40 30 (0.3) Elderly (n=36) 73 (6.9) 14 (5.1) 8/25 29 (1) Alzheimer's Disease (n=16) 76 (7.8) 14 (4.3) 5/11 24 (2.6) Semantic Dementia (n=3) 66 (11) 14 (1.2) 3/0 27 (2.1) Episodic Semantic Young OK OK Elderly +/- OK Alzheimer's Disease OUT +/- Semantic Dementia +/- OUT Memory Errors? Elderly False memories → Alzheimer False memories & intrusions → Semantic dementia Semantic errors → How to differentiate clinical populations? Few clinical tests rely on a qualitative approach Populations Episodic/Semantic Memory Test Adaptation of the Pyramid and Palm Trees Test Learning phase Test phase Material 32 cards with 3 line-drawing items: (1) reference (2) good match (3) distractor 64 cards: - 32 good matches - 16 distractors - 16 new items Tasks Matching task Learn the correct match Free recall Recognition task Delayed free recall Naming task Learning phase Errors qualification Reference Good match Item to learn Distractor Distinct Memory Profiles Conclusions Distinct profiles: Semantic Dementia (/others) ←→ Semantic errors Aging (/young) ←→ Confusions Alzheimer's Disease (/others) ←→ Intrusions HIT CONFUSION OR INTRUSION PPTT / Buschke Encoding Sum Free Recall Sum Cued Recall Delayed Free Recall Matching -0.14 0.22 0.12 -0.14 Free Recall 0.17 0.60* 0.46* 0.42* Free Recall – Conf 0.1 0.03 0.11 0.01 Delayed Free Recall 0.1 0.50* 0.25 0.35* Delayed Free Recall – Conf 0.09 -0.43* -0.39* -0.26 Recognition -0.01 0.34* 0.21 0.1 Recognition – Conf -0.07 0.08 -0.05 -0.11 Naming -0.05 0.14 0.18 -0.19 A validated memory test Notes. Correlations between the PPTT adapted and the Buschke memory test. Conf = confusions; * = p<0.05; Intrusions not included due to lack of variance. A valid memory test? - episodic memory test (correlations) - semantic memory test (remain to be assessed) Use a qualitative approach of memory errors Young | poster |
Contact Sören Tholen (PhD student) Jolien Linckens (PhD) Stuctural Geology Goethe University Frankfurt tholen@geo.uni-frankfurt.de linckens@em.uni-frankfurt.de +49 (0) 69 798 40194 - R e c r y s t a l l i z a t i o n m e c h a n i s m , m i x i n g i n t e n s i t y a n d n e o b l a s t a s s e m b l a g e d e p e n d e n t o n r e c r y s t a l l i z e d p h a s e a n d i t s m i c r o s t r u c t u r a l p o s i t i o n . - P h a s e m i x i n g i s s i m u l t a n o u s t o r e c r y s t a l l i z a t i o n o f o p x a n d c p x p o r p h y r o c l a s t s i n c o n t a c t t o o l - m a t r i x . - O l p o r p h y r o c l a s t s r e c r y s t a l l i z e b y d y n a m i c r e c r y s t a l l i z a t i o n w i t h m i n o r a m o u n t s o f m i x i n g b y G B S . - T h i s s t u d y h i g h l i g h t s t h e i m p o r t a n c e o f n e o b l a s t n u c l e a t i o n f o r p h a s e m i x i n g ; M e c h a n i c a l m i x i n g s o l e l y b y g r a i n b o u n d a r y s l i d i n g i s n e g l e c t a b l e i n t h e i n v e s t i g a t e d L a n z o s h e a r z o n e . C o n c l u s i o n : ¡ ¢ C l i n o p y r o x e n e p o r p h y r o c l a s t s r e c r y s t a l l i z e f r o m p o r p h y r o c l a s t i c t e x t u r e s o n w a r d s f o r m i n g a n i n s t a n t m i x o f c p x ( ~ 6 1 a r e a % , ~ 2 1 µ m ) a n d o l ( ~ 3 1 a r e a % , ~ 1 8 µ m ) i n m y l o n i t e s ( 1 ) . C p x g e n e r a l l y d i s p l a y s b i g g e r g r a i n s i z e s a n d h i g h e r a b u n d a n c e s t h a n o p x i n o l + o p x a s s e m b l a g e s . M i x i n g i n t e n s i t i e s a r e e x p l i c i t l y h i g h ( 6 6 % p h a s e b o u n d a r i e s ) . R e c r y s t a l l i z a t i o n s i d e s i s o l a t e d f r o m t h e o l - b e a r i n g m a t r i x s h o w a s i g n i f i c a n t l o w e r a m o u n t o f p h a s e m i x i n g ( 2 ) . C l i n o p y r o x e n e R e c r y s t a l l i z e d c p x p o r p h y r o c l a s t s i s o l a t e d f r o m o l - b e a r i n g m a t r i x R e c r y s t a l l i z e d c p x p o r p h y r o c l a s t s i n c o n t a c t t o o l - b e a r i n g m a t r i x U p t o m y l o n i t i c t e x t u r e s o r t h o p y r o x e n e o c c u r s a s ± e q u i a x i a l p o r p h y r o c l a s t s a n d b a n d s . I n m y l o n i t e s b o t h r e c r y s t a l l i z e , f o r m i n g a n i n s t a n t f i n e - g r a i n e d m i x t u r e o f o l ( ~ 5 6 a r e a % , ~ 1 3 µ m ) a n d o p x n e o b l a s t s ( ~ 3 7 a r e a % , ~ 1 4 µ m ) ( 1 ) . T h e p h a s e m i x i n g i n t e n s i t y i s e x c e p t i o n a l l y h | poster |
Decellularized extracellular matrix (ECM) hydrogels can be used to recapitulate the in vivo peri-islet niche. Creative Proteomics provides protein characterization services that can qualitatively and quantitively analyze the target protein and its post-translational modification. Characterization of Porcine Decellularized Tissues Protein Characterization Organ-on-a-chip platforms are cost-efficient testbeds for screening pharmaceutical agents, mimicking biological systems, and modeling human diseases. In the field of diabetes, the development of an islet-on-a- chip platform would have broad applications on understanding pathology and discovering potential therapies. Leveraging microphysiological systems for the long-term culture of primary pancreatic islets, however, has been limited by poor stability of these cells ex vivo, with the key factor being the disruption of islet-matrix interactions following isolation. The use of decellularized tissues integrates a diverse spectrum of biochemical and biophysical cues, adapted from natural biomaterials, for the encapsulated cells to be viable and functional. The composition of the ECM can be tailored by selecting the tissue source and the decellularization approach. In order to determine the protein composition of porcine decellularized tissues, protein characterization was performed. To characterize protein composition, decellularized tissue samples were analyzed using Dionex Ultimate 3000 Nano LC system coupled with an Orbitrap Q Exactive mass spectrometer. ASSAY OVERVIEW | poster |
Bayesian Regression on segmented data using Kernel Density Estimation Extending Bayes‘ theorem The challenge of having to deal with dependent variables in classification and regression using techniques based on Bayes' theorem is often avoided by assuming a strong independence between them, hence such techniques are said to be naïve. While analytical solutions supporting classification on arbitrary amounts of discrete and continuous random variables exist, practical solutions are scarce. However, not only can we extend Bayes’ theorem to any number of events, we may also use continuous random variables instead, or any combination of both. Random variables however require a conditional density, which, in practice, is not given. We can estimate that density, by first segmenting the dataset using conditions for discrete variables, or the empirical conditional distribution function. This allows us to practically solve a non- naïve version of Bayes’ theorem where we assume full conditionality between all variables. The full general form for classification is shown below: Centre for Data Intensive Sciences and Applications Data-driven Software and Information Quality Group Sebastian Hönel, Morgan Ericsson, Welf Löwe, Anna Wingkvist Data-driven Software and Information Quality Group – Centre for Data Intensive Sciences and Applications Linnaeus University, 351 95 Växjö, Sweden {sebastian.honel, morgan.ericsson, welf.lowe, anna.wingkvist}@lnu.se 𝑃𝐿= 𝑙𝑋1 = 𝑥1, … , 𝑋𝑛= 𝑥𝑛= 𝑝(𝐿=𝑙) ς𝑚=1 𝑛 𝑝(𝑋𝑚=𝑥𝑚|𝑋𝑚+1=𝑥𝑚+1,…,𝑋𝑛=𝑥𝑛,𝐿=𝑙) ς𝑚=1 𝑛 𝑝(𝑋𝑚=𝑥𝑚|𝑋𝑚+1=𝑥𝑚+1,…,𝑋𝑛=𝑥𝑛) , where each conditional p(𝑋𝑚= 𝑥𝑚| … ) is one of ൝𝑃𝑋𝑚= 𝑥𝑚𝑋𝑚+1 = 𝑥𝑚+1, … , 𝑋𝑛= 𝑥𝑛[, 𝐿= 𝑙]), 𝑖𝑓𝑋𝑚𝑖𝑠𝑑𝑖𝑠𝑐𝑟𝑒𝑡𝑒, 𝑃𝐷𝐹𝑋𝑚|𝑋𝑚+1=𝑥𝑚+1,… ,𝑋𝑛=𝑥𝑛[, 𝐿=𝑙] 𝑥𝑚, 𝑜𝑡ℎ𝑒𝑟𝑤𝑖𝑠𝑒. And, accordingly, ∀𝑋𝑚∈𝑋segmentation is done by ቊ𝑋𝑚= 𝑥𝑚, 𝑖𝑓𝑋𝑚𝑖𝑠𝑑𝑖𝑠𝑐𝑟𝑒𝑡𝑒, 𝑋𝑚≤𝑥𝑚, 𝑜𝑡ℎ𝑒𝑟𝑤𝑖𝑠𝑒. If all variables are discrete, the general form yields a probability for L = 𝑙, a likelihood, otherwise. This is still useful, as we can simply determine the most likely label መ𝑙= 𝑎𝑟𝑔𝑚𝑎𝑥𝑃𝐿= 𝑙… ∀𝑙∈𝐿. This is called the maximum a posteriori estimation (MAPe). For each label, the strength of the class membership is also indicated. The general form can be simplified to become a Bayesian network, by waiving conditioning over the desired label. Then also, the evidence (denominator, normalizing constant) would become equal to the likelihood (numerator). If relinquished, the simple form looks as in the following equation: 𝑌′ = 𝑃𝑋1 = 𝑥1, … , 𝑋𝑛= 𝑥𝑛= ෑ 𝑚=1 𝑛 𝑝(𝑋𝑚= 𝑥𝑚|𝑋𝑚+1 = 𝑥𝑚+1, … , 𝑋𝑛= 𝑥𝑛) This simplified form still assumes dependence between all variables. Note that 𝑌′ holds all remaining values after segmenting. This allows us to perform a regression, by estimating a kernel density (KDE). Using that empirical PDF, similar to MAPe, a most-likely value can be obtained by finding the highest mode of the PDF, i.e., ො𝑦= 𝑎𝑟𝑔𝑚𝑎𝑥𝑃𝐷𝐹𝑌′ 𝑦, 𝑦∈𝑌′. The developed models allow for a few hyperparameters. We demonstrate the effect of each w.r.t. the current performance metric, i.e., Accuracy or 𝑅2 (the squared Pearson covariance). In order to be able to utilize the full general form, a label would be required. If our target variable were to be continuous, we can discretize it, and then find the most likely range. That range can be used to obtain a Y′ that also holds the most likely values for 𝑦. Using those remaining values, again, we can estimate a kernel density for regression. Predicting the mean would imply assuming a gaussian distribution. KDE, however, allows to estimate an arbitrary distribution from the remaining samples. While the simplified form does not require a label, it is required for the full form. Hence, such a regression is preceded by a classification. Acc. Impr. Kappa Runt.(s) Method Dataset 0.65 0.00 0.00 0.12 ZeroR breast (Class) 0.65 0.00 0.00 8.00 Simple 0.89 0.24 0.75 43.80 Full 0.38 0.00 0.00 0.12 ZeroR chick (Diet) 0.93 0.55 0.90 5.95 Simple 1.00 0.62 1.00 16.89 Full 0.70 0.00 0.00 0.12 ZeroR credit (Class) 0.69 -0.01 0.06 6.37 Simple 0.70 0.00 0.00 | poster |
Institute of Mineral Engineering, RWTH Aachen mail: kieliba@ghi.rwth-aachen.de Ilona KIELIBA ESR Position 05 Thermal cyclic characteristic of alumina-spinel steel ladle brick Dr.-Ing. Thorsten TONNESEN, RWTH Aachen Prof. Marc HUGER, University of Limoges The study of the thermal cyclic characteristic of alumina-spinel steel ladle brick constitutes an initial part of the Ph.D. ATHOR project dedicated to monitoring of gradual fatigue to thermal cycling. Within the framework of this project alumina – spinel refractories, both brick and monolithic solutions will be characterized under thermal cycling conditions. Obtained results will contribute to a better understanding of the microstructural and thermomechanical degradation phenomena taking place in industrial processes and support modeling surveys by providing valuable data regarding damage kinetics. EXPERIMENTAL PROCEDURE: • Resonant frequency and damping measurements have been utilized for the continuous monitoring of microstructural changes taking place in alumina – spinel brick exposed to heating-cooling cycling. • Temperature dependence of the Young’s modulus has been shown to exhibit typical for refractories hysteresis shape. • As expected high temperature damping measurement has been proven to be more sensitive to microstructural alterations and therefore reveals some phenomena that are undetectable by Young’s modulus measurements. • Two step evolution of microstructural changes in the temperature range 1000 -1500°C should be further investigated, but it is very likely that complex alumina spinel solid- state reactions determine material behaviour at this heating and cooling stage. Supervisors & Industrial mentors Acknowledgments This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement no.764987 Consortium of 15 European Partners Dr. Erwan GUÉGUEN, RHI MAGNESITA References: 1. Tonnesen, T. & Telle, R. Thermal shock damage in castables: microstructural changes and evaluation by a damping method. Ceramic Forum Int. 84, 1–5 (2007). 2. Tessier-Doyen, N., Glandus, J. C. & Huger, M. Untypical Young’s modulus evolution of model refractories at high temperature. J. Eur. Ceram. Soc. 26, 289–295 (2006). Alumina-spinel brick is being increasingly used in steel industry applications, especially in steel ladles mainly due to growing need of ultralow carbon metallurgy. Damage of refractories in secondary furnaces is induced by several factors like corrosion and abrasion but also thermal spalling and extensive thermal cracking, originated from prolonged thermal cycling, constitute a serious concern. For the design of the cyclically loaded material, knowledge of the elastic properties and their evolution with temperature and thermal history is a fundamental requirement. Continues monitoring of Young's modulus value and damping behaviour versus temperature provide a substantial information about the microstructural alterations taking place in the material exposed to thermal cycling conditions. Especially damping measurements, which have been proven to be very sensitive in detecting and following microstructural phenomena as: crack initiation and propagation1, stress relaxation, phase transition, diffusion and precipitation, should by increasingly implemented in the microstructural studies. Determination of damping temperature dependency can deliver information undetectable by other techniques, which will constitute an additional scientific basic for further development and microstructural material optimization. Young's modulus behaviour under thermal cycling conditions Prof. Rainer TELLE, RWTH Aachen In the literature2 typical hysteresis curve and stages observed during heating and cooling of the refractory material are described and explained as follow: • At intermediate temperatures because of CTE mismatches between the phases a crack closure and therefore, an increase in Young's modulus is observed. During cooling an | poster |
www.helmholtz-hzi.de P04: Chemical and biological diversity of secondary metabolites from basidiomycetes. Blondelle Matio Kemkuignou1, Khadija Hassan1, Kathrin Wittstein1, Clara Chepkirui1, Ashaimaa Y. Moussa2, Cony Decock3, Josphat C. Matasyoh4, Marco Kirchenwitz5, Theresia E. B. Stradal5, Monique Rascher-Albaghdadi6, Reinhard W. Köster6, Marc Stadler1,* 1Department of Microbial Drugs, HZI, Inhoffenstrasse 7, 38124 Braunschweig, Germany 2Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt 3Mycothéque de l’Université Catholique de Louvain (BCCM/MUCL), B-1348 Louvain-la-Neuve, Belgium 4Department of Chemistry, Egerton University, P.O. Box 536, Njoro 20115, Kenya 5Department of Cell Biology, HZI, Inhoffenstrasse 7, 38124 Braunschweig, Germany 6Department of Cellular and Molecular Neurobiology,TU Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany New Amylosporanes A-G (1-7) isolated from Amylosporus sp. together with 8 previously reported compounds C H3 CH3 C H3 CH3 CH3 OH OH O H O H H 1 C H3 CH3 C H3 CH3 CH3 OH OH O H O 1 OH OH Cl O H N NH O O H OH OH H O OH OH H OH O H H OH H OH O OH 12 13 14 10 9 15 11 8 3 5 1 8 1'' 2'' 1' 2' 5' 4' OH OH 7 O H O 4'' 5'' 3 5 1 1'' 2'' O 8 1' 2' 5' 4' 7 O OH OH 5'' 4'' O H 3 4 6 1 1'' 2'' 5'' 4'' OH 8 7 O OH O 1' 2' 5´ 4´ O H 3 1 5 1´ 2´ 5´ 4´ O O 1´´ 2´´ OH 5´´ 4´´ 7 1 2 3 7 5 6 3 5 1 1'' 2'' 5'' 1' OH OH 8 7 4'' 2' 5' 7' 4' 10' 9' OH O (E) (E) (E) (E) 3 5 1 1'' 2'' 5'' 4'' 1' 2' 4' 5' H OH OH 8 1´ 7 3 6 5 O H O O O 1 2´ 4´ 5´ 3 2 4 5 O 6 OH 1 O 1´ 3´ 4´ 5´ 3 5 1 OH OH 7 O OH 8 1´ 2´ 5´ 4´ 7´ 10´ 9´ H (E) (Z) 3 5 1 1´´´ 2´´´ 5´´´ 7´´´ 10´´´ 9´´´ 1´´ 5´´ 4´´ O 1´ 5´ 4´ 7 O O H 8 OH 4´´´ 4 (E) Orsellinic acid-derived carbons 1H-1H COSY 1H-1H NOESY 1H-13C HMBC Structure Elucidation The structures of the compounds were determined using spectroscopic methods (HR-ESIMS, UV, IR, CD, 1D and 2D NMR) Introduction Natural products have played a key role in drug discovery, especially for cancer and infectious diseases. However, the rampant rise of antimicrobial resistance to known drugs is the biggest threat to public health worldwide, which necessitates the search for hitherto untapped sources of novel, effective drugs. Basidiomycota has been recognized as a prolific source of secondary metabolites, with prominent and selective biological activities even though it remains widely underexplored. In particular, not only African relatives of the traditional edible and medicinal Asian mushrooms such as Sanghuangporus and Laetiporus but also rare and endemic tropical species of genera that have never been studied before for bioactive constituents, such as Heimiomyces, have recently yielded interesting secondary metabolites. This study describes the evaluation of Amylosporus cf. campbelii and Amylosporus cf. graminicola that were isolated from specimens collected in Zimbabwe and Cuba, respectively, and from which no secondary metabolites have hitherto been reported. Extracts of the strains of the Amylosporus spp. showed moderate antibacterial effects in our screening for novel anti-infective metabolites along with a unique HPLC/ DAD-MS metabolite profile, and we selected these fungi for an evaluation of the active principles. [1] Additionally, the neurotrophic properties of triterpenes isolated from fruiting bodies of Laetiporus sulphureus [2] and a mycelial culture of Antrodia sp. MUCL 56049 was investigated. Several triterpenes potently stimulated the expression of neurotrophic factors, namely, NGF (sulphurenic acid, 15α-dehydroxytrametenolic acid, fomefficinic acid D, and 16α-hydroxyeburicoic acid) and bdnf (sulphurenic acid and 15α-dehydroxytrametenolic acid). The triterpenes also potentiated NGF-induced neurite outgrowth in PC-12 cells. This is, to the best of our knowledge, the first report on the compound class of lanostanes in direct relation to bdnf and ngf enhancement [3]. L. sulphureus Photo: Marc Stadler Laetiporus sulphureus Antrodia sp. MUCL 56049 Am | poster |
mMass as a Software Tool for the Annotation of Cyclic Peptide Tandem Mass Spectra Timo H. J. Niedermeyer1, Martin Strohalm2 1 Institute of Pharmacy, EMA-University, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany, and Cyano Biotech GmbH, Magnusstr. 11, 12489 Berlin, Germany 2 Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20 Prague, Czech Republic Introduction Natural or synthetic cyclic peptides often possess pronounced bioactivity. Their mass spectrometric characterization is difficult due to the predominant occurrence of non-proteinogenic monomers and the complex fragmentation patterns observed. Even though several software tools for cyclic peptide tandem mass spectra annotation have been published, these tools are still unable to annotate a majority of the signals observed in experimentally obtained mass spectra. They are thus not suitable for extensive mass spectrometric characterization of these compounds. The lack of an advanced and user-friendly software tool has motivated us to extend the fragmentation module of a freely available open-source software, mMass (http://www.mmass.org), to allow for cyclic peptide tandem mass spectra annotation and interpretation. The resulting software has been tested on several cyanobacterial and other naturally occurring peptides and has been found to be superior to other tools currently available concerning both usability and annotation extensiveness. Thus it is highly useful for accelerating the structure confirmation and elucidation of cyclic as well as linear peptides and depsipeptides. Main Features and Implemented Fragmentation Pathways • off-line tool with advanced spectrum manipulation and processing abilities (e.g. support for various data formats, baseline correction, peak picking etc.) • ability to save spectra, sequences and interpretation results for future use • monomer database and editor for easy monomer and sequence management • matching of calculated theoretically possible fragments to and annotation of experimental data • backbone fragmentation pathways after initial break-up to a b-like ion resulting in a-, b-, c-, x-, y-, and z-like fragment ions (Figure 1) • alternative initial a/x-like ring opening resulting in +CO fragment ions (Figure 2) • sequence scrambling • neutral losses of e.g. H2O and NH3 as well as custom side chain losses from individual monomers • multiple neutral losses from one fragment • formation of b+H2O fragment ions (Figure 3) Figure 1 Backbone fragmentation of a cyclic peptide taking Microcystin LF as an example. Figure 3 Proposed mechanism for the formation of observed b+H2O ions of Cryptophycin-1. Microcystin LF Cryptophycin-1 NRP-Annotation 23 32 mMass* 23 32 mMass** 95 80 Figure 1 Proposed pathway for the formation of an observed N-formyl fragment ion of microcystin LF after initial protonation of D-alanine. Figure 5 Tandem mass spectra of Microcystin LF (A) and cryptophycin-1 (B). Signals discussed are indicated with a star (filled star: not annotated by NRP-Annotation). Table 1 Percentage of the ion intensity annotated using NRP-Annotation or mMass. * options chosen reflecting the fragments NRP-Annotation can calculate ** all available options chosen Case Study I – Microcystin LF The fragmentation behavior of microcystins, cyclic heptapeptides found in several cyanobacterial genera, has been very well studied. Thus microcystin LF (Figure 4) has been used to examine the accuracy and comprehensiveness of our fragmentation algorithms and to compare the results to the software NRP-Annotation. The tandem mass spectrum of microcystin LF (Figure 5) shows several significant peaks that had not been assigned by NRP-annotation, but were annotated by mMass. • m/z 478.2644 annotated as c4[7|1][1-4] (Δ 3.3 ppm) • m/z 561.3017 annotated as c5[6|7][1-5] (Δ 2.5 ppm) • m/z 559.3127 annotated as z5[2|3][3-7] - C9H10O, at (Δ 0.2 ppm) • m/z 693.3816 annotated as z5[2|3][3-7] (Δ 3.1 ppm) * • m/z 852.4 | poster |
PRESENCE OF SALMONELLA SPP. AND HEPATITIS E VIRUS IN ITALIAN PIG FARMS G. Ianiro1, E. Pavoni 2,G. Aprea3, R. Romantini3, G. Alborali2, D. D’Angelantonio3, G. Garofolo3, S. Scattolini3, L. De Sabato1, F. Ostanello4, I. Di Bartolo1. 1) Istituto Superiore di Sanità, Dept. Food Safety, Nutrition and Veterinary public Health, Rome Italy; 2) Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini", Brescia, Italy; 3) Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "Giuseppe Caporale", Teramo, Italy; 4) University of Bologna, Faculty of Veterinary Sciences, Ozzano dell’Emilia, Italy. • Salmonella spp. was detected in 14/47 (29.8%) farms, while HEV was detected in 16/47 (34.0%) farms. • The highest Salmonella spp. prevalence was in breeding farms (8/18 positive farms, mean individual prevalence 14.4% per farm), while for HEV was in fattening farms (9/22 farms positive, mean individual prevalence 53.9% per farm) by testing young animals aged 3-4 months. . This poster is part of the European Joint Programme One Health EJP. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No 773830. RESULTS METHODS EU is the second worldwide producer of pig meat after China and the biggest exporter worldwide. Due to the importance of this production for both economy and public health, being pork widely consumed, its whole food chain is strictly monitored to guarantee highly safe food. Salmonella spp., is a main cause of foodborne outbreaks, while hepatitis E virus (HEV) is a recently recognized emerging zoonotic foodborne pathogen, whose role need to be still defined. Pigs are reservoirs of both. In the framework of the European Joint Programme “Biosecurity practices for pig farming across Europe (BIOPIGEE)”, the presence of Salmonella spp. and HEV in pig farms over EU countries was evaluated. In Italy, 47 pig farms were investigated, including 22 finishing, 18 breeding, and 7 farrow-to-finish farms, by collecting a total of 958 pooled fecal samples. CONCLUSION AND PERSPECTIVES In conclusion, the main source of contamination of pigs is represented by the farming stage, probably due to the environmental contamination. Subsequently the monitoring of pigs at farm and the implementation of biosecurity measures remains critical to reduce the risk of slaughtering infected animals. BREEDING Total tested Positive (%) Total tested Positive (%) HEV 5 (27,77%) 20 (5,37%) Salmonella 8 (44,44%) 23 (6,18%) FATTENING Total tested Positive (%) Total tested Positive (%) HEV 9 (40,90%) 97 (21,74%) Salmonella 6 (27,27%) 23 (5,15%) 22 446 Farms Fecal pool samples 18 372 Farms Fecal pool samples FARROW-TO-FINISH Total tested Positive (%) Total tested Positive (%) HEV 2 (28,57%) 17 (12,14%) Salmonella 0 (0,00%) 0 (0,00%) TOTAL Total tested Positive (%) Total tested Positive (%) HEV 16 (34,04%) 134 (13,98%) Salmonella 14 (29,78%) 46 (4,81%) Farms Fecal pool samples 47 Farms Fecal pool samples 7 958 140 | poster |
The Social Media for Learning in Higher Education Conference 2019 Dawne Irving-Bell, Edge Hill University and Lauren S. Schlesselman, University of Connecticut Beginning as strangers selected for participation in an International Collaborative Writing Group (ICWG), where group members are geographically located thousands of miles apart this work serves to address the question “Can social media be utilised to effectively support international collaborative writing?” Adopting an approach informed by collaborative autoethnography, focused on their experiences this work illuminates the stories of two of the six participants as they sought to establish themselves and their position within the group. Illuminating the challenges encountered the purpose of this preliminary study is to support others who may be engaged in or considering undertaking work of a similar nature. As such this presentation will be of interest to any colleagues thinking about using social media as a means of communication when engaged in collaborative academic work where geographical locations prevent physical engagement. Telling our stories Using social media to bridge geographical boundaries • Cultural differences in expectations and approaches to work • Finding suitable dates, and especially a suitable time to meet virtually • Interpreting written communication (namely emails) to understand the nuances of what was actually being said • Collating everyone’s ideas, ensuring everyone had a voice and an equal stake in the conception of the paper • Don’t assume anything! Don’t be afraid to ask for clarification, and always double check everything • Start by identifying who is good at what, and we don’t just mean in relation to writing, so who is best placed to set up work areas or host and schedule online meetings • Take time to reflect your understanding of what has been said and then articulate it back to the group to ensure everyone is on the same page • Use multiple means of communication • Meet online as often as you can, always consolidating discussions with follow up messaging, emails and texts • Try to meet physically if you can and when you do start with a social activity and schedule as many social activities together as you can! What were our Success Our tips for differently? What would we do Challenges? | poster |
Star Formation in SpARCS J0330: Bridging the Gap Between Protoclusters and Clusters 1Imperial College London, Blackett Laboratory, Prince Consort Road, London, SW7 2AZ, UK ● 2ASU School of Earth and Space Exploration, 781 Terrace Mall, Tempe, AZ 85287, USA 3MIT Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA 4Departamento de Ciencias Físicas, Universidad Andres Bello, Fernandez Concha 700, Las Condes 7591538, Santiago, Región Metropolitana, Chile ● 5Department of Physics and Astronomy, University of California, Riverside, CA 92521 J. Cairns1, D. L. Clements1, A. Noble2, M. McDonald3, Y. Ding1, J. Nantais4, G. Wilson5 1. Background At z > 2, many studies have identified protoclusters - overdensities of galaxies spanning tens of Mpc in size and hosting some of the most vigorous star formation observed in the Universe to date. Conversely, galaxy clusters are typically observed at z < 1 and are massive, virialised and abundant in quiescent, elliptical galaxies. Current models of galaxy formation and evolution predict that protoclusters will evolve into z ~ 0 massive galaxy clusters (e.g. Cooke et al. 2015), and so there must be some rapid, environmentally-driven quenching of star formation at that transforms high-z, star-forming protoclusters into massive, quiescent galaxy clusters. However, the exact nature of this evolution remains poorly understood. In order to understand this evolution, we must search for overdensities of galaxies at the onset of cluster formation at which time we can observe the full web of activity: the assembly of a collapsed cluster core feeding on the star-forming filamentary material that resides in the protocluster web. z ∼1 4. SED Fitting 2. SpARCS J0330 We present observations of SpARCS J0330, one of the most massive, high-z galaxy clusters ever discovered (Lidman et al. 2012). SpARCS J0330 resides in the Chandra Deep Field South (CDFS) at a redshift of , with a dynamical mass of . We combine the photometry and spectroscopy compiled by Nantais et al. (2016) with our own observations, as well as ancillary data in the field, to build up Spectral Energy Distributions (SEDs) for the 40 spectroscopically confirmed cluster members, as well as potential cluster members, with up to 20-band photometry. We use the photometric fitting codes EAZY (Brammer et al. 2008) and CIGALE (Boquien et al. 2019) to estimate the properties of these sources and hence map out distant, star-forming galaxies over a region in the cluster. z = 1.626 ∼2.5 × 1014 M⊙ ∼15 Mpc 3. Sample Selection 1. Spec-z sample: Comprising the 40 spectroscopically confirmed cluster members. Available photometry includes u, g, r, i, z, y, J, H and K observations from IMACS, HAWK-I and HST, IRAC and MIPS photometry from Spitzer and PACS and SPIRE photometry from Herschel. 2. Photo-z sample: Sources with the same photometry as the spec-z sample but without a spectroscopically confirmed redshift. 3. Photo-z wide sample: Sources in the wider field from the Spitzer Data Fusion catalogue, including photometry from the HerMES, SWIRE, SERVS, VHS and VIDEO surveys, as well as CTIO MOSAIC2. 4. Field sample: We additionally assemble a field sample of sources from the Spitzer Data Fusion catalogue spread across the XMM-LSS field. We use the photometric fitting code EAZY to estimate photometric redshifts for the photo-z, photo-z wide and field samples, allowing us to select likely cluster candidates (see Figure 1). We then use CIGALE to estimate galaxy properties for all four samples. We use the sfhdelayedbq module to parameterise the star formation history according to: for with the option of an instantaneous recent variation in SFR. We include a Chabrier IMF with solar metallicity and a dust attenuation curve based on that of Calzetti et al. (2000). We use the nebular emission module and the Casey2012 dust module which models the FIR dust peak as a simple modified blackb | poster |
for Julia Priess-Buchheit, Joeri K. Tijdink, Katharina Miller, Sean Lacey, Peter Eduard, Marie Alavi (and more from NERQ_OS Group)Julia Priess-Buchheit, Joeri K. Tijdink, Katharina Miller, Sean Lacey, Peter Eduard, Marie Alavi (and more from NERQ_OS Group) OS enables transparancy, accessibility, collaboration, knowledge circulation & valorisation and innovation. Higher education lacks tailored OS training resources for various stakeholders of the scientific community. Recognising that while openness is vital, only high-quality research output with legally and ethically justified openness is reliable and reasonable. We reviewed literature, activated representatives for the OS learner groups and screened the OS training resources from the groups 1, 4 and 7. We extracted RI and RE principles provided in these training resources. We statuated umbrella concepts of OS training resources: We create OS target groups Educational Goals RESEARCHER POLICY MAKER OS EDUCATOR As open as possible - as closed as necessary FAIR data & other outputs As open as possible - as closed a s necessary Data protection & Intellectual property Open research: Data, Access, Code, OER, Source etc. Monitoring & Evaluation Reproducibility (data/ methodology etc. sharing) Reproducibility Open science & inclusiv e infrastructures Proceeding data collection Help us to create an intersection of of high-quality and reliable OS training using our questionnaire: your training resources on principles recommended by the research community using our questionnaire. gaps or needs for further training and your resources. Get your training resources if you meet at least 80% of the recommended principles. your training resources to the Open Science Learning Gate. the intersection for your training of specific stakeholders. reach out: buchheit@paedagogik.uni-kiel.de alavi@zke-kiel.de NERQ's intersection of OS training resources targeting specific learning groups promoting principles inevitable for current research Principles RESEARCHER POLICY MAKER OS EDUCATOR Accountability Awareness Accountability (Self-)Awareness Collaboration, Community building, Hollistic engagement Awareness Honesty, Equity & Fairness Honesty, Diversity & Inclusiveness Quality & Integrity Ethics Openness Reliability Incentives, Recognition, Encouragement Reliability (tools, infrastructures, actors) Respect Data confidentiality Respect Responsibility Explainability Responsibility Transparency Traceability Proceeding data collection (see QR-code) Accessibility Bias-free speech, data and outcomes Fairness Harm- monitoring Guardrails to ensure scientific values Data confidentiality, quality Privacy, Data & IP protection Safety Transparency Value-based algorithmi c decision-making Proceeding data collection (see QR-code)a Collection of important OS training principles Assesment and hig h quali ty badging OPEN SCIENCE Learning Gate tailored capacity building for OS training Open Science Learning Gate Data Research Infrastructure Support Professional RESEARCH INTEGRITY RESEARCH ETHICS ETHICS of AI operating with OS NERQ’S OS Principles in the OPEN SCIENCE LEARNING GATE OS Educator/ Trainer 7 8 Join us in the OPEN SCIENCE LEARNING GATE Policy Maker Data Curator Data Steward/ Data Librarian/ Figure: Adapted from EOSC’s definition of Actors in the EOSC Ecosystem (1) 4 5 6 Authors: Julia Priess-Buchheit, Marie Alavi With contribution of: Joeri K. Tijdink, Katharina Miller, Ruth Moran, Varga Orsolya, Maruxa Martinez, Ulf Tölch, Sean Lacey , Peter Eduard, Anita Lunić (and more from NERQ_OS Group)With contribution of: Joeri K. Tijdink, Katharina Miller, Ruth Moran, Varga Orsolya, Maruxa Martinez, Ulf Tölch, Sean Lacey, Peter Eduard, Anita Lunić (and more from NERQ_OS Group) Lack of tailored OPEN SCIENCE training for different stakeholders OPEN SCIENCE Learning Gate as tailored & high-quality intersection The Problem 1 Researcher University Student Citizen Research Soft- ware Engineer Data Scientist/ Analyst En | poster |
I Repositories e il caso di “BASE” (Bielefeld Academic Search Engine) Lepri Francesco Antonio, Lupparelli Luca, Pazzagli Francesca, Romeo Lorenzo Studenti dell'insegnamento di Documentazione (A.A. 2020/21), Dipartimento di Lettere-Lingue, Letterature e Civiltà antiche e moderne, Università degli Studi di Perugia Una introduzione all’Open Access: La “Via d’Oro” e la “Via Verde” Che cos’è un Repository e a che cosa serve? Quali tipologie di Repositories ci sono? Quali contenuti possiamo trovare in un Repository? Il caso di “BASE” (Bielefeld Academic Search Engine): Bibliografia: - Abadal Ernest, Open Access. L’Accesso Aperto alla letteratura scientifica, Milano, Ledizioni, 2014, consultabile gratuitamente e liberamente all’URL: http://www.ledizioni.it/stag/wp-content/uploads/2016/03/Open-Access_def.pdf - Sito di BASE consultabile all’URL: https://www.base-search.net/ - Sito di OpenDOAR consultabile all’URL: https://v2.sherpa.ac.uk/opendoar/ - Sito di Wikipedia consultabile all’URL: https://it.wikipedia.org/wiki/Pagina_principale - Le immagini sono ad uso gratuito e libero secondo gli standard Creative Commons (CC) e sono state scaricate dal sito: https://search.creativecommons.org/ This presentation poster was designed byFPPT. Aspetti tecnici e “harvesting” : Open Access, Repository, Via Verde, Harvesting, BASE (Bielefeld Academic Search Engine) Nell’ambito della comunicazione scientifica, l’insieme delle dinamiche utilizzate dai ricercatori affinché i risultati delle loro ricerche trovino diffusione, si inserisce l’accesso aperto. La letteratura ad accesso aperto si contraddistingue per due capisaldi: la gratuità dei suoi contenuti e la loro libertà da ogni restrizione di diritti di licenza. L’obiettivo primario è quello di liberare la ricerca scientifica da tutti i lacci, sia economici che legali, che ne possano ostacolare la diffusione dal momento che un contenuto in accesso aperto può non solo essere consultato gratuitamente da un utente ma anche scaricato, copiato, stampato o distribuito. In tale contesto lo sviluppo e la diffusione di internet hanno assunto un ruolo chiave: senza la possibilità di digitalizzare i contenuti e di diffonderli in maniera immediata non sarebbe stato possibile favorire un accesso libero e gratuito alla scienza. Una tappa fondamentale per la nascita del movimento dell’accesso aperto è stata segnata dalla Dichiarazione di Budapest del 14 febbraio 2002, partorita da una conferenza organizzata a Budapest nel dicembre 2001 dall’Open Society Institute. La Dichiarazione oltre a contenere una prima definizione di accesso aperto individua due strategie da seguire per raggiungerlo: ●La pubblicazione di riviste ad accesso aperto, strategia che si riferisce all’opzione in cui gli autori pubblicano i propri articoli direttamente in riviste ad accesso aperto e che prende il nome di “via d’oro”. ●L’archiviazione in repositories, strategia che prevede per gli autori il deposito delle proprie pubblicazioni (preprints o postprints) in repositories ad accesso aperto e che prende il nome di “via verde”. Proprio dei repositories ci occuperemo più nel dettaglio in questo poster. Il logo dell’Open Access. Fonte: CC Search. Un repository è un sito web che raccoglie, conserva e diffonde la produzione accademica di un’istituzione, permettendo l’accesso agli oggetti digitali che contiene e ai suoi metadati. I repositories: ●Contengono pubblicazioni derivate dalla ricerca: articoli di riviste, relazioni sulla ricerca, congressi, tesi di dottorato. In molti di essi si possono trovare informazioni accademiche di portata più ampia come: materiale didattico e attività istituzionali. ●Di solito contengono i testi completi di questi documenti, la disponibilità del testo completo è un elemento basilare per permettere gli obbiettivi dell’Open Access. Tuttavia, a volte possono anche contenere solo alcuni capitoli o sezioni di un documento. ●Autorizzano l’accesso ai metadati, di modo che i riferimenti bibliografici di ogni documento | poster |
Design, Implementation and Iteration of a Digital Preservation Processing Workflow Eamon Smallwood (eamon.smallwood@kaust.edu.sa), Marcelo Garcia (marcelo.garcia@kaust.edu.sa) University Library, King Abdullah University of Science and Technology (KAUST) https://library.kaust.edu.sa/ Iteration 1 Iteration 2 Iteration 3 Design Workflows describe, justify, and plan for the implementation of a sustainable, long-term digital preservation service at KAUST University Library Each workflow was designed with a specific audience in mind: Iteration 1: University Library Management and University IT Iteration 2: University Library Preservation and Digital Services Team Iteration 3: University Library Systems Team Designed in accordance with international standards and best practice for digital preservation(OAIS ISO 14721) Designs evolved due to: Assessment of existing storage solutions at KAUST Procurement of dedicated digital preservation technology and services Automation of workflow processes Implementation In 2020, the University Library began implementing the preservation processing workflow(Iteration 1) to bring our digital preservation capabilities in line with international standards and best practice Assessments revealed that the existing storage infrastructure was not well suited for long- term preservation In 2021, the University Library procured two key components of the preservation processing workflow: Dedicated digital preservation service – Preservica Dedicated digital preservation workstation – FRED (Forensic Recovery Evidence Device) Processed all University Library Archives digital collections into Preservica via FRED(Iteration 3) in December 2021 In 2022, the University Library began automating the preservation workflow processes(Python), available on Github - https://github.com/kaust-library/ArchiveAutomation/ ClamAV Archivera to Bagger integration DROID JHOVE Iteration Iteration 1: Making the case for a dedicated digital preservation service • High level • Designed to justify investment in a digital preservation service to Library Management and University IT • Minimal detail • Workflow components based on existing KAUST IT Infrastructure Iteration 2: Comprehensive preservation processing workflow • Internal documentation • Represents the end to end preservation workflow process, from appraisal to long-term preservation • Pre-Preservica implementation Iteration 3: Preservation ingest workflow • Internal documentation • Maps the first series of steps in the long-term preservation process • Working documentation for digital preservation processing procedures • Ideal workflow for identifying workflow process appropriate for automation Future Work Continued automation of the preservation workflow Identify and assess redundant processes in the preservation workflow | poster |
SEGMENTATION OF CLOUD PATTERNS FROM SATELLITE IMAGES TO IMPROVE CLIMATE MODELS Kirill Vishnyakov† and Mukharbek Organokov‡ †Peter the Great St.Petersburg Polytechnic University, ‡Universit´e de Strasbourg kirill.a.vishnyakov@gmail.com, mukharbek.organokov@gmail.com Introduction Climate change has been at the top of our minds and at the forefront of important political decision-making for many years [1]. Classification of different types of clouds is substantial for understanding climate change. Human ability to identify patterns is limited and murky boundaries between different forms of clouds lead to obstacles in traditional rule-based al- gorithms cloud features separation [1]. In these situations, machine learning techniques, particularly deep learning, have demonstrated their ability to mimic the human capacity for identifying patterns in the clouds using satellite images [2]. This work focuses on seg- mentation of four subjective patterns of clouds organization [2] (see Fig. 1): Sugar, Flower, Fish, Gravel. (a) Sugar (b) Flower (c) Fish (d) Gravel Figure 1: Canonical examples of the four cloud organization patterns. Method Dataset The dataset used in the analysis is released on the Kaggle platform [1]. The images with three regions, spanning 21 degrees longitude and 14 degrees latitude, were taken from NASA Worldview [3]. The labels were created on a crowd-sourcing platform [4]. On cloud labeling days at two institutes, 68 scientists screened satellite images, identified areas of cloud patterns in each image, and each image was labeled by approximately 3 different sci- entists [1]. Ground truth was determined by the union of the areas marked by all labelers for that image, after removing any black band area from the areas [1]. The ground-truth masks presented in the dataset are quite noisy meaning they include a lot of areas that ac- tually do not contain clouds at all. Also, the masks of different classes can overlap. These two facts significantly increase problem complexity. The resolution of original images is 1400×2100, in our experiments we use downscaled images, namely we work with three different image resolutions: 352×512, 512×768, 768×1152. Example of images containing different number of clouds patterns is shown in Fig. 2. Figure 2: Images of clouds with corresponding masks. Metric The mean Dice coefficient (DC) [5] is chosen as the metric to measure the performance of the model by pixel-wise comparison of the predicted segmentation (Ypred) output and the corresponding ground truth (Ygt). If Ypred = ∅and Ygt = ∅, then DC = 1; otherwise, it is defined as: 2|Ypred ∩Ygt| |Ypred| + |Ygt| (1) The objective of this research is to develop a DL model that ensures higher accuracy. Thus, the goal is to maximize the model on the mean DC so that a perfect model achieves an accuracy of 1. Architecture and Implementation This problem was treated as a semantic segmentation task with four different classes. During the past years numerous architectures (see Fig. 3) have been developed to tackle the problem of semantic segmentation including the most famous U-Net [6], LinkNet [7], FPN [8], PAN [9]. In this work, we used U-Net architecture. Figure 3: Simplified schematic view of the architecture. We developed a two-stage (S1 and S2) semantic segmentation pipeline [10] (see Fig. 4) that accepts images with corresponding ground-truth masks and outputs raw (non- normalized) predictions for each of four classes. Then during the post-processing proce- dure predictions are normalized with sigmoid function to eliminate masks of insufficient size. Thus, final processed predictions were generated. Figure 4: Pipeline. Experiments Our main experiments with data included training on two stages with different image res- olutions and different set of pseudo-labels (PLs). Recently, a semi-supervised approach became popular and provided improvements in training procedure. We used approach similar to [11] in which authors first trained an EfficientNet model | poster |
Vigneshwari Subramanian1,a, Bence Szalai1, Luis Tobalina1, Julio Saez-Rodriguez1,2,b Application of network diffusion approaches to drug screenings: A perspective on multilayered networks derived from drugs and cell lines References PrECISE is supported (in part) by the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number 15.0324-2. The opinions expressed and arguments employed therein do not necessarily reflect the official views of the Swiss Government. The PrECISE project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668858. Funding www.saezlab.org @sysbiomed • RWR-MH can be used effectively to identify the most relevant genes associated with drug response • RWR-MH offers the possibility to predict patient-specific drug responses based on patient-cell line networks Conclusions / Perspectives PrECISE (Personalized Engine for Cancer Integrative Study and Evaluation) is a European H2020 project focused on prostate cancer, an international collaboration that aims to translate into clinical advances many of the technical and methodological developments achieved during the last years. • Identify the genes related to drug response by applying RWR-MH to a multilayered network that incorporates protein-protein interactions, drug-drug similarities, cell line-cell line similarities and co-expressed genes • Decipher targets for drugs whose mechanism of action is not well-elucidated • Guide drug sensitivity predictions based on the genomic status of a selected list of genes identified through RWR-MH Study Aims 1. RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, MTZ, Pauwelsstrasse 19, 52074-Aachen, Germany 2. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus CB10 1SD Hinxton, United Kingdom b) saezrodriguez@combine.rwth-aachen.de a) subramanian@combine.rwth-aachen.de • Multiplex heterogeneous networks (networks with multiple interconnected layers) could provide significant information to understand the global topology, when compared to the networks that rely on single type of information1,2 • Random Walk with Restart on Multiplex Heterogeneous networks (RWR-MH) have been shown to effectively identify candidate genes of not well-studied diseases2 • Random walk with restart algorithm allows to explore all neighbours in close proximity to the seed nodes (diseases/ genes/ drugs) Background 1. Li, Y., Patra, J.C. (2010) Bioinformatics 26 (9), pp.1219-1224. 2. Valdeolivas, A., Ticket, L., Navarro, C. Et al. (2017) bioRxiv. DOI:10.1101/134734 3. Iorio, F., Knijnenburg, T.A., Vis, D.J. et al. (2016) Cell, 166(3), pp. 740-754. Drug-Drug similarity (766): Pearson’s correlation coefficient based on normalised IC50s from GDSC (one drug against all cell lines) > 0.6 Cell line-Cell line similarity (1548): Pearson’s correlation coefficient based on normalised IC50s from GDSC (one cell line against all drugs) > 0.6 Pathways / PPI (254766): Reactome, Biocarta, KEGG, InnateDB, Uniprot Coexpression (15319): Pearson’s correlation coefficient based on Gene expression from GDSC (One gene across all cell lines) > 0.6 Construction of Drug-Gene-Cell Line Networks Seeds 265 drugs from GDSC3 Key Inferences Decipher targets of uncharacterised drugs based on Drug-Drug similarities Genes used Pearson’s correlation (Average of all drugs) All genes available in GDSC (17419) 0.42 Network genes identified by RWR-MH (500) 0.44 Performances of Random Forests drug response prediction models based on gene expression ANOVA: Prioritised genes from RWR-MH are among the most significant ones that relate to drug response. Models based on network genes are as predictive as the models with all the available genes. ANOVA Correlation between Drug sensitivities and Mutation / CNV of network genes + MSI status +GDSC tissues IC50 ~ Mut / CNV / Gene Expression (gene) + MSI status + GDSC | poster |
LOS MEDIOS INFORMATICOS AL 2023 JACKELLINE SUSANA FELIPE RIVERA LEIVIZ OMAR GARCIA ALCEQUIEZ ONELDY AQUINO RAMOS YANIRA POLANCO PACHECO Docente: Kenia Arias Introducción A continuación presentamos nuestra investigación acerca de los medios informáticos en el 2023 cuyo propósito es contribuir al objetivo 4 de desarrollo sostenible al 2030 que propone las Naciones Unidas (2018) “asegurar el acceso igualitario a todos los niveles de la enseñanza y la formación profesional para las personas vulnerables, incluidas las personas con discapacidad, los pueblos indígenas y los niños en situaciones de vulnerabilidad”. daremos a conocer tres aspectos, primero hacemos una descripción de conceptos, características tipos y clasificación en segundo lugar indicamos cuales son los medios informáticos mas utilizados en el ámbito educativo y ejemplos en tercer lugar proponemos un medio informático que podría ser útil a la sociedad. I Conceptos Universidad Abierta Para Adultos, R.D. USIN ARTIFICIAL INTELIGENCE uapa. Autores: Jackelline Susana Felipe Rivera Leivys Omar Garcia Alcequiez Oneldy Aquino Ramos Yanira Polanco Pacheco Docente: Kenia Arias Multi media Chats A continuación presentamos nuestra investigación acerca de los medios informáticos en el 2023 cuyo propósito es contribuir al objetivo 4 de desarrollo sostenible al 2030 que propone las Naciones Unidas (2018) “Asegurar el acceso igualitario a todos los niveles de la enseñanza y la formación profesional para las personas vulnerables, incluidas las personas con discapacidad, los pueblos indígenas y los niños en situaciones de vulnerabilidad”. daremos a conocer tres aspectos, primero hacemos una descripción de conceptos, características tipos y clasificación en segundo lugar indicamos cuales son los medios informáticos mas utilizados en el ámbito educativo y ejemplos en tercer lugar proponemos un medio informático que podría ser útil a la sociedad. LOS MEDIOS INFORMATICOS Iimagen creada por ia DALLE Universidad Abierta Para Adultos, R.D. I Conceptos ¿QUE ES UN MEDIO INFORMATICO? Cabero (1998) destaca que los medios informáticos se refieren a documentos digitales que tienen la capacidad de integrar una variedad de componentes, como textos, sonidos, animaciones, imágenes fijas y en movimiento, así como fragmentos de vídeos. Barajas (2009) que los medios tecnológicos en los procesos de enseñanza-aprendizaje son las Tecnologías de la Información y la Comunicación (TIC) que se conforman a partir de procesos y productos derivados de las herramientas de hardware y software, las cuales actúan como soportes en el almacenamiento, procesamiento y transmisión digitalizada de la información LLuquinga-Quispe et al., (2022) Se incluyen diferentes soportes creados en función de garantizar la adquisición de conocimientos. CARACTERISTICAS DE LOS MEDIOS INFORMATICOS Cabero (1996) los clasifica en inmaterialidad, interactividad, instantaneidad, innovación elevados parámetros de calidad de imagen y sonido, digitalización, influencia más sobre los procesos que sobre los productos, automatización y diversidad. Podemos distinguir tambien según Barajas (2009) Almacenamiento de Datos: Los medios informáticos permiten el almacenamiento de grandes cantidades de datos en formato digital. Rapidez y eficiencia: Facilitan la rápida lectura, escritura y manipulación de datos. Capacidad de Procesamiento: Los medios informáticos pueden procesar datos de manera eficiente mediante dispositivos como procesadores, CPUs, entre otros. CLASIFICACION Y TIPOS DE MEDIOS INFORMATICOS Imagenes tomadas de Garcia Aretio, Lorenzo (2014) García.(2014) clasifica los medios informáticos en dos grandes tipos, los medios uno el cual se puede usar en la educación a distancia o virtualidad y la otra que se podría usar en la presencialidad. También clasifica los medios de acuerdo a la metodología que se desee usar , de acuerdo al software y de acuerdo a los dispositivos que se usen. Capacidad de Conectividad: Los medios informáticos suelen tener | poster |
Innovative Research for a Sustainable Future www.epa.gov/research Developing tools for high resolution mass spectrometry-based screening via the EPA’s CompTox Dashboard Andrew D. McEachran1,2*, Kamel Mansouri3, Hussein Al-Ghoul4, Alex Chao4, Chris Grulke2, Jon R. Sobus5, and Antony J. Williams2 1Oak Ridge Institute of Science and Education (ORISE) Research Participant, Research Triangle Park, NC 2U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, NC 3Integrated Laboratory Systems, Inc., Morrisville, NC | 4Oak Ridge Associated Universities, Research Triangle Park, NC 5U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, NC * mceachran.andrew@epa.gov l ORCiD: 0000-0003-1423-330X Problem Definition and Goals The CompTox Dashboard MS-Ready Structures for Database Searching MS/MS Data in NTA/SSA References Acknowledgements 1. Williams, AJ, et al. 2017. The CompTox Chemistry Dashboard: a community data resource for environmental chemistry. J Cheminf. https://doi.org/10.1186/s13321-017-0247-6 2. McEachran, AD, et al. 2017. Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard. Anal. Bioanal. Chem. 409(7): 1729-1735. doi:10.1007/s00216-016-0139-z 3. McEachran, AD, et al. 2017. A comparison of three chromatographic retention time prediction models. Talanta. https://doi.org/10.1016/j.talanta.2018.01.022 4. McEachran, AD, et al. 2018. “MS-Ready” structures for non-targeted high-resolution mass spectrometry screening studies. J Cheminf. Accepted for publication. 5. Allen, et al. 2015. Competitive fragmentation modeling of ESI-MS/MS spectra for putative metabolite identification. Metabolomics. https://doi.org/10.1007/s11306-014-0676-4 6. Newton, SR, et al. 2018. Suspect screening and non-targeted analysis of drinking water using point-of-use filters. Environ Poll. https://doi.org/10.1016/j.envpol.2017.11.033 Applications The authors would like to thank Emma Schymanski and Christoph Ruttkies for their valuable contributions on the MS-Ready Structures, associated publication, and integration to MetFrag. The authors would also like to thank Reza Aalizadeh and Nikolaos Thomaidis for use of the UOA-RTI software for retention time index prediction (manuscript submitted for publication). The authors would like to acknowledge the Dashboard development team for their efforts in surfacing all functionality. This work was supported in part by an appointment to the ORISE Research Participation Program at the Office of Research and Development, U.S. EPA, through an interagency agreement between the US EPA and DOE. This presentation does not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Chemical metadata for ranking Problem: Non-targeted and suspect screening studies using high resolution mass spectrometry (HRMS) have revolutionized the detection of chemicals in complex matrices. However, data processing remains challenging due to the vast number of chemicals detected in samples, software and computational requirements of data processing, and inherent uncertainty in confidently identifying chemicals from candidate lists. Goals: Develop tools, data, and visualization approaches within an open chemistry resource to provide a freely available software tool to support structure identification and non-targeted analysis. Home page. The CompTox Dashboard (https://comptox.epa.gov) is a comprehensive chemistry resource containing chemistry data on more than 760,000 chemical substances. (Left and Below) To facilitate database searching, structures in DSSTox were processed into their “MS-Ready” form [4]. This processing workflow removes salts and stereochemistry and separates components of mixtures while retaining linkages to the original structure and substance. This enables the form of a structure observed via HRMS to be relat | poster |
A History Of Changes Millennial Sea Level In The Southwestern AtlanƟc Karla Rubio-Sandoval, Timothy Shaw, Ben Horton, Nicole Khan, Augusto Luiz Ferreira-Júnior, Rodolfo Angulo, Guilherme Lessa, Maria CrisƟna de Souza, MaƩeo Vacchi, Deirdre Ryan, SebasƟan Richiano, Evan Gowan, Ciro Cerrone, Paolo Stocchi, Thomas Lorscheid, Thomas Felis, Ann-Kathrin Petersen, & Alessio Rovere * LIG: SL values from ~5.6 to 20 m a.s.l. in the continent and from ~2 to 10 m a.s.l. in the islands. * HOL: Mid-Holocene maximum transgression rising RSL from 2 to 4 m above its present level. * Relative sea level (RSL) changes result from the interactions between land motion and the global mean sea level. * The elevation of a sample is not the RSL. It requires quantifying other parameters associated with the mean sea level (MSL). Figure 2. Beach ridge indicaƟve range Level is NOT Sea Level! Results Holocene (HOL; ~11 ka – to present) Conclusions Figure 1. Example of a SL indicator. Modified from Rovere et al., 2016 The database flow * Geographic location. * Accurate chronology. * Elevation of the sample with respect to a tidal datum. * The indicative meaning. Four main criteria: Last Interglacial (LIG; ~128-116 ka) The figures on this panel represent the RSLs during the LIG in the Southwestern AtlanƟc. How to study Paleo Sea Levels? * Sea level (SL) reconstructions are developed using sea-level indicators. * The past position of the sea level is defined by sea-level index points or limiting data. Figures on this panel represent the RSLs during the HOL in the Southwestern AtlanƟc. A) Map showing locaƟons of records. B), C), & D) Sea level curves by area. | poster |
Preliminary impacts of reduced mowing in highway ROWs on roadside pollinator abundance and habitat quality Kaitlin Stack Whitney, PhD Introduction • Insect pollinator populations are declining worldwide, primarily due to degradation and loss of habitat. • Roadside ROWs can potentially serve as alternative habitats, but they are also disturbed by road traffic and roadside maintenance. • Reduced mowing may result in more quality habitat through increased floral presence for habitat and foraging. (A) Sites Sites were selected using a multivariate cluster analysis to best represent the surrounding land use, geographic distribution, climactic factors, and road attributes (size, speed limit, traffic) of highways across upstate New York. Each site (n=30) had a block design of 2 miles in a control mowing treatment and 2 miles in a modified mowing treatment. Within each, we had 3 sampling locations per treatment and site. At each sampling location, we visited at least twice per year (generally between May and October). During each visit, we conducted multiple monitoring activities that directly measured pollinator abundance, as well as pollinator habitat quality. (B) Mowing Treatments Control treatment areas received the current mowing schedule. Modified treatment areas received reduced mowing; they were not mowed (except for the safety strip) in 2019 and were mowed in 2020 only after a plant-killing frost. . The experiment will continue into 2021, and modified treatment areas will again (like 2019) not be mowed all season (except for the safety strip). This presentation includes only a portion of the data collected and pollinators observed in the project. Data is preliminary, as another year of data will be collected. Project information is not yet approved by NYSDOT. Study Sites Science, Technology & Society Department, College of Liberal Arts Environmental Science Program, College of Science Rochester institute of Technology Correspondence: kxwsbi@rit.edu Acknowledgments This report was funded in part through grant(s) from the Federal Highway Administration and United States Department of Transportation under the State Planning and Research Program, Section 505 of Title 23, U.S. Code provided by the New York State Department of Transportation. The contents of this report do not necessarily reflect the official views or policy of the United States Department of Transportation, the Federal Highway Administration, or the New York State Department of Transportation. This report does not constitute a standard, specification, regulation, product endorsement, or an endorsement of manufacturers. Thank you to all the NYSDOT staff who supported the planning and safety of this project along NYS highways. Thank you to research assistants who helped sample: Alyssa Schoenfeldt, Virginia Aswad, Debmalya Ray Choudhuri,, Shereef Ghoneim, Jacob Horn, Alyssa Juergens, Matthew Madsen, Thuy Huong Vu, Jay Wickard, and Andrew Yoder. Native Bee and Honey Bee Abundance • Methods: We counted wild bee and honeybee abundance on flower blooms along a 75m linear transect (1). We collected this data twice per year in both 2019 and 2020. While a direct measure of pollinator presence and abundance, it is also a measure of habitat quality for pollinating insects. Invasive/Noxious Plant Species Abundance • Methods: We assessed the proportion of invasive and noxious plant species along a 100m vegetation transect using the line intercept method (2). The species included were: common reed (Phragmites australis), Japanese knotweed (Fallopia japonica), purple loosestrife (Lythrum salicaria), poison ivy (Toxicodendron radicans), wild parsnip (Pastinaca sativa), mile-a-minute (Persicaria perfoliata), oriental bittersweet (Celastrus orbiculatus), Poison sumac (Toxicodendron vernix), and Porcelain berry (Ampelopsis glandulosa). We collected this information twice per year both years. ROW Habitat Working Group Scorecard • Methods: We also used the Rights-of-Way as Habitat Work | poster |
A citizen science approach to govern demand patterns of ecosystem services and their influencing factors – lessons learned from Austria Katrin Karner1, Florian Danzinger2, Thomas Wrbka2, Martin Schönhart3 1 Institute of Sustainable Economic Development, BOKU university, Vienna, Austria katrin.karner@boku.ac.at 2 Department of Botany and Biodiversity Research, University of Vienna, Austria 3 Federal Institute of Agricultural Economics, Rural and Mountain Research, Vienna, Austria Methods Background Nature provides many valued services to people including provisioning (e.g. food), regulating (e.g. filtration of pathogens which improves water quality) and cultural services (e.g. areas for recreation). These services contributing to human well-being are referred to as ecosystem services (ESS) in academic literature. Past research proved the importance of land use (e.g. how farmers manage their agricultural land) for ESS supply. Most academic ESS assessments focused on the supply. However, lacking information on the demand of ESS risks that areas are prioritized for the supply of ESS where the demand of society is small. In the citizen science project ServeToPe, we aim to • test methods for ESS demand assessments by citizens in the Austrian Biosphere Reserve Wienerwald (BRWW), • identify overlaps and gaps of ESS supply and demand in the BRWW, and • inform citizens and regional decision-makers about ESS and sustainable landscape governance. Aim Results Next, results from the online tool and the survey at five locations across the BRWW are presented. The surveys were taken from June 2023 to December 2023 and we obtained 268 full questionnaires/data sets and 359 partial. Results include frequencies of undertaken or observed activities in the BRWW, the importance of different ESS, improvement needs for matching supply and demand of ESS, governance criteria and good governance practices (like the mountainbike platform). 0% 20% 40% 60% 80% 100% Collecting food (Herbs /… Meditation Other Sports (Biking, Running) Learning (from/about… Nature observation Walk / Hike Daily Weekly Several times a month Once a month Several times a year Once a year Never The citizen scientists mentioned following needs for improvement regarding recreation and habitat for species. Conclusions Overall, the citizen scientists identified highest demand for cultural services but services related to biodiversity and habitat conservation were evaluated as high likewise. Our lessons learned show that (i) engaging different citizens groups leads to complementary results on ESS, (ii) effective and tailored communication to each citizen group is of key relevance and (iii) online tools proved particularly useful. However, the evaluation of the tested instruments identified the supply of ESS and the need for improvement by the citizen scientists rather than the demand. Acknowledgments This research was part of the resrach project Servives to the people – better governane of ecosystem services at local scales in the Wienerwald region (ServeToPe) funded through the Top Citizen Sciences initiative of the Austrian Science Fund (FWF). N=70 N=359 Figure 2: Overview of the frequency of observed and undertaken activities in the biosphere reserve Wienerwald Figure 3: Overview of the need for improvement for recreation and habitat for species in the biosphere reserve Wienerwald (a) identification of the extent of the need of improvement and (b) word cloud on mentioned needs Figure 1: Overview of the methods applied in the research project ServeToPe We engaged with different citizen groups, applying different methods. E.g., we designed one online tool for a one-time reporting of regularly undertaken and observed uses of ESS in the BRWW, one for a regular reporting and held workshops. | poster |
Stable soliton comb from dual ring microresonators Motivation Frequency combs are usually generated using mode locked lasers, featuring narrow comb line spacing (~100MHz). Whereas, microresonator based combs present: Large comb line spacing (10 to 500 GHz) Low optical power operation The stability of microresonator based combs depends on the detuning of the laser with respect to the pump resonance. Our work aims at increasing the stability and the spectral purity of the comb lines. Spectroscopy Telecommunication Astronomy Precision measurements Frequency synthesizing LiDAR Frequency comb Applications 1. Helgason, Ó.B., Arteaga-Sierra, F.R., Ye, Z. et al. Dissipative solitons in photonic molecules. Nat. Photonics 15, 305–310 (2021). 2. Xue, Xiaoxiao, Qi, Minghao and Weiner, Andrew M.. "Normal-dispersion microresonator Kerr frequency combs" Nanophotonics, vol. 5, no. 2, 2016, pp. 244-262. References Abstract: We present a packaged SiN dual-ring resonator for frequency comb generation. Using a low frequency noise pump laser and active temperature stabilization we alleviate frequency drifts and detuning fluctuations. The resulting solitons are stable over several hours. Anamika Karunakaran1,2, Angelo Manetta1, Poul Varming1, Óskar B.Helgason3,Patrick Montague1, Minhao Pu2, Victor Torres-Company3, Kresten Yvind2 1 NKT Photonics, Birkerød, Denmark, 2 Technical University of Denmark, Kgs. Lyngby, Denmark, 3Chalmers University of Technology, Gothenburg,Sweden Dual ring microresonator In our experiment, we use dual ring resonators manufactured in Chalmers University of Technology, Sweden [1]. These achieve the localized anomalous dispersion by evanescent coupling between two rings with slightly different free spectral range. The degeneracy point of these rings can be tuned using a heater on the auxiliary ring which enables use of pump lasers at any convenient frequency. Figure : a) Dispersion profile of our microresonator [1] b) Drawing of the dual ring resonator c) Wavelength of mode crossing with respect to heater voltage Microresonators • High Q (~106) with 𝜒3 nonlinearity • Exhibit either anomalous or normal dispersion • Free spectral range ranging from ~10 GHz to 500 GHz In normal-dispersion microresonators, a mode with localized anomalous dispersion can be engineered by coupling different resonator modes.[2] Solitons are then generated by pumping this mode. Normal-dispersion microresonators typically yield combs with higher conversion efficiency than anomalous dispersion microresonators. Comb generation When light is coupled to the main ring, thermal effects redshift its optical resonance. Tuning the laser from the blue side to the red of the main resonance allows to generate our comb. In order to attain a coherent mode-locked state, both the voltage to the auxiliary-ring heater and the laser frequency are finely tuned. Frequency combs are generated via cascaded four wave mixing process exploiting the 𝜒3 properties and high Q value of our microresonator. Figure : Experimental setup for comb generation Figure : Generation of soliton. The laser is first detuned to the blue side of the resonator (Step 1). Fine adjustment of both the laser frequency and heater voltage bring about the appearance of comb lines (Step 2 and 3). Step 4 shows the final comb. Results We generated a soliton comb from a dual ring microresonator. Soliton stability depends on the detuning between the laser and the optical resonance of the main ring. To improve the stability, • Our device was packaged using buttcoupled high NA fibers. • Using low frequency noise NKT single frequency laser, we reduced detuning fluctuations . • By temperature stabilisation of the packaged device, the thermal drift of the resonance was curbed. After adding the TEC, the life span of solitons increased from 20 minutes to up to 5 hours. Figure : (a)The optical spectrum of the generated soliton comb. (b) The corresponding ESA spectrum of the comb lines. Figure (a) The packaged and | poster |
Economic and Operational Reliability Benefits of Wave Energy Integration in the U.S. Western Interconnection Kerem Ziya Akdemir1, Bryson Robertson2,3, Konstantinos Oikonomou2, Jordan Kern1, Nathalie Voisin2,4, Diane Baldwin2, Saptarshi Bhattacharya2 1 North Carolina State University; 2 Pacific Northwest National Laboratory; 3 Oregon State University; 4 University of Washington 1. Introduction 2. Methods 3. Results 4. Conclusions 5. References Motivation: • Renewable energy integration is critical for ensuring a sustainable and decarbonized future energy landscape. As grids are decarbonized, grid operators need to find alternative methods to maintain reliability during normal operations and extreme weather events. • Marine energy resources (including wave, tidal, and ocean currents) have significant potential to emerge as effective clean generation alternatives. • Compared to other renewable resources such as solar and wind, wave energy and tidal energy are more periodic, persistent, and predictable. • Wave energy is the most scalable among marine energy resources and its integration into bulk power system operation has proven potential to improve operational reliability and resiliency. Research Objective: Studying the effect of wave power integration on power system operations through an optimization-based unit commitment/economic dispatch (UC/ED) model under: ➢Different transmission expansion scenarios, ➢Extreme weather scenario, ➢Transmission line contingency scenario. [1] Akdemir, K. Z., Robertson, B., Oikonomou, K., Kern, J., Voisin, N., Hanif, S., & Bhattacharya, S. (2023). Opportunities for wave energy in bulk power system operations. Applied Energy, 352, 121845. https://doi.org/10.1016/j.apenergy.2023.121845 [2] Akdemir, K. Z., Oikonomou, K., Kern, J. D., Voisin, N., Ssembatya, H., & Qian, J. (2024). An open-source framework for balancing computational speed and fidelity in production cost models. Environmental Research: Energy, 1(1), 015003. https://doi.org/10.1088/2753-3751/ad1751 [3] Bhattacharya, S., Pennock, S., Robertson, B., Hanif, S., Alam, M. J. E., Bhatnagar, D., Preziuso, D., & O’Neil, R. (2021). Timing value of marine renewable energy resources for potential grid applications. Applied Energy, 299, 117281. https://doi.org/10.1016/j.apenergy.2021.117281 Figure 1: Reduced order 134-node representation of U.S. Western Interconnection (GO WEST model) Session Number/Abstract ID: GC15/1292933 Contact Information: kakdemi@ncsu.edu • Open-source production cost modeling framework for the U.S. Western Interconnection (GO WEST) is used as a baseline to create the specific test case for wave energy integration. This is a Python-based software where the users can create a reduced network representation of U.S. interconnections through customization parameters and simulate grid operations through a UC/ED model. • In order to study the impact of marine renewable energy (MRE) resources in a scalable manner, a systematic model reduction is performed to design an equivalent reduced topology for the entire U.S. Western Interconnection. • In this study, we selected 134 nodes to represent grid operations. 10 nodes throughout the Western Interconnection are selected specifically to host wave power generators (2 in Washington, 4 in Oregon, and 4 in northern California). • GO WEST’s objective is to minimize the total cost of providing necessary electricity to meet the total demand across the entire power system, subject to constraints that restrict the generator commitment and dispatch decisions such as generator ramp rate limits and maximum generator capacities. • Model outputs include the generation schedule of each generator, power flow on each transmission line, locational marginal prices (LMP) at each node, and unserved energy at each node. Integrating Wave Energy without Transmission Expansion Figure 2: Average nodal LMP changes due to wave power integration for 2 wave power capacities in 2019 without transmission expansion ( | poster |
SGD and the Alliance of Genome Resources Stacia R. Engel, Edith D. Wong, Robert S. Nash, Felix Gondwe, Kevin A. MacPherson, Patrick Ng, Suzi Aleksander, Stuart Miyasato, J. Michael Cherry, and The SGD Project Department of Genetics, Stanford University, Stanford, CA 94305, USA The yeast research community has long enjoyed the support provided by the Saccharomyces Genome Database (SGD), and has flourished because of its existence, making great breakthroughs and technological advances, and contributing countless key insights to the fields of genetics and genomics over the past decades. SGD has recently joined forces with five other model organism databases (MODs) - WormBase, FlyBase, ZFIN, RGD, and MGI - plus the Gene Ontology Consortium (GOC) to form the Alliance of Genome Resources (the Alliance; alliancegenome.org). The Alliance website integrates expertly-curated information on model organisms and the functioning of cellular systems, and enables unified access to comparative genomics and genetics data, facilitating cross-species analyses. The site is undergoing rapid development as we work to harmonize various datatypes across the various organisms. Explore your favorite genes in the Alliance to find information regarding orthology sets, gene expression, gene function, mutant phenotypes, alleles, disease associations and more! The Alliance is supported by NIH NHGRI U24HG002223-19S1, NIH NHGRI U41HG001315 (SGD), NIH NHGRI P41HG002659 (ZFIN), NIH NHGRI U24HG002223 (WormBase), MRC-UK MR/L001020/1 (WormBase), NIH NHGRI U41HG000739 (FlyBase), NIH NHLBI HL64541 (RGD), NIH NHGRI HG000330 (MGD), and NIH NHGRI U41HG002273 (GOC, which also provides funding to WB, MGD, SGD). Goal: develop and maintain sustainable genome information resources that facilitate the use of diverse model organisms to understand the genetic and genomic bases of human biology, health, and disease Yeast, human, and model organism orthologs ! Alleles and phenotype variants ! Disease associations ! Expression sgd-helpdesk@lists.stanford.edu ! @yeastgenome @alliancegenome ! help@alliancegenome.org | poster |
I) Extinction ( ) and accretion luminosity ( ) Av Lacc ✓In this analysis we considered the following lines as accretion diagnostics: , , , and lines, together with the Ca II triplet lines. ✓The measured fluxes of these emission lines have been combined with the Gaia DR2 distance (Gaia Collaboration et al. 2018) of pc to derive the line luminosities ( ). ✓From each of them we evaluated the accretion luminosity ( ) by making use of the empirical relations of Alcalá et al. (2017). In this way, we estimated the weighted mean accretion luminosity ( ), as illustrated in Fig. 1. ✓We have developed a new approach to estimate the extinction of our source, which corresponds to the value minimizing the relative error of (Fig. 2). To this end, we corrected the observed spectra for extinction using the extinction law by Weingartner & Draine (2001) that covers the wavelength range of the X-shooter spectra. Hα Hβ Hγ Hδ 151 ± 14 Lline Lacc,line Lacc,line −Lline ⟨Lacc,line⟩ Av ⟨Lacc,line⟩ Variability of the mass accretion rate in the very low-mass star Par-Lup3-4 A. Klutsch1, B. Stelzer1,2, J. M. Alcalá3, A. Frasca4, C. F. Manara5, A. Scholz6 1 IAAT Tübingen, Germany, E-mail : klutsch@astro.uni-tuebingen.de • 2 INAF-OA Palermo, Italy • 3 INAF-OA Capodimonte, Napoli, Italy 4 INAF-OA Catania, Italy • 5 European Southern Observatory, Garching bei München, Germany • 6 SUPA St. Andrews, UK Acknowledgments • This work is supported by the Deutsche Forschungsgemeinschaft (DFG) project number 413113723. References • Alcalá, J. M., et al. 2017, A&A, 600, A20 ; Comerón, F., et al. 2003, A&A, 406, 1001 ; Gaia Collaboration, Brown, A. G. A., et al. 2018, A&A, 616, A1 ; Manara, C. F., et al. 2013, A&A, 558, A114 ; Weingartner, J. C. & Draine, B. T. 2001, ApJ, 548, 296. Virtual conference March 2-4, 2021 Accretion and outflows are key processes in early stellar evolution. The material accreted at the edge of the inner disc is channeled along magnetic funnel flows onto the star. Its kinetic energy is dissipated in standing accretion shocks. The accretion process is therefore sensitive to the spatial and temporal variations of the structure of the magnetic field and its mass load. Due to the change of view of the star-disc system throughout the rotation cycle, geometric effects are superimposed on such intrinsic variability and likely dominate the observed variability. An assessment of changes in the mass accretion rate is essential to understand the structure of the star-disc-magnetosphere system. The young, very low-mass star Par-Lup3-4 displays a rich emission-line spectrum, hosts a disc with an almost edge-on inclination, and is in the critical mass range near the star/brown dwarf transition, where the knowledge of the accretion/outflow connection remains rather poor. These properties make this star a prime target for conducting a variability study of mass accretion. We make use of X-shooter's unique capabilities to monitor its broad-band spectrum in the range from ultraviolet to near-infrared. The sampling of our ten spectra covers timescales of hours, days, weeks, and years. ✓The values are almost constant over time (Fig. 3), with the exception of the spectrum acquired in 2012 (i.e., epoch 2). ✓Due to a bad seeing, the error on is higher and, as a consequence, the determination of is poorer in epochs 3 6. ✓We evaluated the weighted average extinction at: ‣ mag with the method described by Manara et al. (2013). ‣ mag with the approach presented in Sect. I. ✓These values agree with each other within the errors and are consistent with those in the literature for Par-Lup3-4, which range from 2.4 to 5.6 mag (Comerón et al. 2003). ✓We also obtained a good agreement between the values derived with these two methods (Fig. 4). ✓After correcting for the extinction, a small variation of can be seen (Fig. 5). We obtained , which corresponds to a mass accretion rate of or . Av Lacc,line Av − ⟨Av⟩ 1.95 ± 0.25 2.35 ± 0.25 Lacc Lacc log(Lacc/L⊙) = −3.0 ± 0.1 log( ·Macc) | poster |
ww w.uni-frankfurt.de Hintergrund In Zentraloman gibt es viele verlassene Lehmziegelsiedlungen und Lehmzie- gelquartiere, letztere in den Zentren der modernen Städte. Es wird davon aus- gegangen, dass ihre Auflassung im Zuge von Modernisierungsprozessen seit den 1970er Jahren erfolgte. In jüngerer Zeit stehen die Lehmziegelsiedlungen im Zentrum konfliktiver Deutungsprozesse. Wissenschaftler und nationale In- stitutionen warnen vor dem Verfall dieses einzigartigen kulturellen Erbes; die lokale Bevölkerung hat an einer aktiven Nutzung eher geringes Interesse, will die Siedlungen aber auch nicht aufgeben. Die verlassenen Siedlungen sind damit zwar bauliche Vergangenheit, ragen aber deutlich wahrnehmbar und zugleich umstritten in Gegenwart und Zukunft. Öffentlichkeitsarbeit Verschiedene Maßnahmen wurden ergriffen, um das Projekt in der Öf- fentlichkeit sichtbar zu machen. Dies umfasst unter anderem eine Kurz- filmserie der Gerda-Henkel-Sfitung, verschiedene Zeitungsartikel sowie eine geplante Posterausstellung an den verschiedenen beteiligten Uni- versitäten. Ziele Ziel dieses von der Gerda Henkel-Stiftung geförderten interdisziplinären Ver- bundprojektes zwischen Archäologie, Soziologie und Islamwissenschaften ist es, die soziale Relevanz der verlassenen Lehmziegelsiedlungen verstehbar zu machen. GIS-Verteilungskarte der Funde in Al-Qabrayn Münzen aus Al-Malah Arbeiten zu den Kurzfilmen der Gerda Henkel-Stiftung Keramik aus Al-Qabrayn und Safrat al-Khashbah Ergebnisse Eine der wichtigsten Erkentnisse des archäologischen Teilprojekts ist, dass die meisten untersuchten Siedlungen lange vor 1970 verlassen wurden und damit deutlich früher als bislang allgemein angenommen. Daher müssen andere Ursachen als die Modernisierung des Landes für ihre Auflassung in Betracht gezogen werden. Kleinfunde Tonobjekte Lithik Metallobjekte Schmuckobjekte Tierknochen Keramik feine und mittelgrob, mineralisch gemagerte Waren grobe, mineralisch gemagerte Waren glasierte Waren Porzellan Fundverteilung Al Qabrayn Methoden Irini Biezeveld Archäologie: Das archäologische Teilprojekt be- fasst sich zum einen mit der Kartographie und Bauaufnahme fünf ausgewählter Lehmziegelsiedlungen in der Region Al-Mudhaybi. Ein anderer Schwerpunkt sind Oberflächensur- veys mit Artefaktsammlung sowie Ausgrabungen, um die Frage zu klären, wann die Siedlungen ge- gründet, wann aufgelassen und wann und wie nachge- nutzt wurden. Für die Frage der Datierung spielt insbesondere die Keramikauswertung eine Rolle. Josephine Kanditt Thomas Schmidt-Lux Soziologie: Das soziologische Teilprojekt be- schäftigt sich zum einen mit theoreti- schen Konzepten zu „Lost Cities“, insbesondere der Frage, was eine „Lost City“ ist, untersucht aber auch empirisch den Wandel der Lehmziegelsiedlungen in Oman anhand von Berichten in Zeitun- gen, Social Media, Tourismus-Por- talen und anderen Quellen. So wird eine wissenssoziologischen Diskursana- lyse zur Wahrnehmung und Be- wertung von Lehmziegelsiedlun- gen durchgeführt. Birgit Mershen Islamwissenschaften: Im islamwissenschaftlichen Pro- jektteil steht die räumliche Manifestation sozialer Strukturen im Vordergrund. Um diese zu untersuchen, kommen Begehungen sowie die Auswertun- gen historischer und aktueller Fo- toaufnahmen sowie historischer Schriftquellen zum Einsatz. Eine wichtige Frage hierbei ist es, welche Strukturen proaktiv erhal- ten und welche dem Verfall preis- gegeben werden. Eng verbunden damit ist die Frage, wie die Lehm- ziegelsiedlungen heute wahrge- nommen werden. Stephanie Döpper PD Dr. Stephanie Döpper Irini Biezeveld, MA doepper@em.uni-frankfurt.de irinibiezeveld@gmail.com @Archaeo_Oman @Irini0696 www.archaeoman.de Zwischen Verklärung und Vernachlässigung | poster |
Overview Seismology is a data and model-intensive field. Data-driven computations benefit from Cloud Computing because observational seismology relies on horizontal scalability. Model-driven computation benefits from High-Performance Computing because simulations necessitate large memory and a high number of workers for efficient parallelization. Our project SCOPED (Seismic COmputational Platform for Empowering Discovery) aims to bridge both observational and theoretical fields by building a CyberInfrastructure (software, data) as a service to the seismic community. The challenges ahead are the benchmarking of open-source codes in cloud and HPC environments, the containerization of these codes adapted to various computing architectures, and the choice of data formats adapted to both Cloud and HPC computing, among others. PI TEAM: Carl Tape (ctape@alaska.edu); PI: full waveform modeling, earthquake source characteristics and uncertainties [UAF: OAC-CSSI 2104052] Ebru Bozdag (bozdag@mines.edu), co-PI: full waveform inversion and tomography [MINES: OAC-CSSI 2103621] Marine Denolle (mdenolle@uw.edu); co-PI: ambient noise seismology and cloud computing [UW: OAC-CSSI 2103701] Felix Waldhauser (felixw@ldeo.columbia.edu), co-PI: earthquake source precisions and catalogs [Lamont/Columbia: OAC-CSSI 2103741] Ian Wang (iwang@tacc.utexas.edu), co-PI: high-performance seismology, filesystem, database [TAAC/UT: OAC-CSSI 2103494] References and Links SeisNoise: https://github.com/tclements/SeisNoise.jl MSPASS: https://www.mspass.org/ MTUQ: https://uafgeotools.github.io/mtuq/index.html SPECFEM3D: https://github.com/geodynamics/specfem3d SPECFEM3D_GLOBE: https://github.com/geodynamics/specfem3d_globe Pyatoa: https://pyatoa.readthedocs.io/en/latest/ SCOPED base container: https://github.com/SeisSCOPED/container-base SCOPED containers: https://github.com/orgs/SeisSCOPED/packages Ambient Noise on the cloud: https://github.com/Denolle-Lab/C4-Project.jl ASDF: https://seismic-data.org/ ADIOS: https://adios2.readthedocs.io/en/latest/ SCOPED: Seismic COmputational Platform for Empowering Discovery [Year 1] NSF Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Frameworks Project Advancing science with SCOPED codes SCOPED focuses on four seismological applications enabled by several open-source software packages. We seek to improve these packages, while also containerizing them for easier use by others. Seismic wavefield modeling with spectral-element method simulations Wavefield simulations within 3D Earth models provide synthetic seismograms that can be compared with recorded seismograms, either to better understand earthquake sources or to improve the subsurface characterization of Earth’s structure. A schematic diagram of the proposed SCOPED Cyberinfrastructure that combines computation (left) and data (right). The SCOPED deliverables will be either fully functional (dark blue) or prototyped (light blue). The external components that SCOPED will interact with (gray) are either computing facilities, data archives, and users. Representation of the unified and interconnected SCOPED Cyberinfrastructure described in the science components and cyberinsfrastructure. At the top, the global map of seismic stations represents one of several featured sources of data sets. Data are hosted and processed on HPC and on Cloud clusters, which overly pillars of wavefield simulations (left column) and data processing and analysis (right column). Cross-disciplinary research will facilitate the investigations of outstanding questions about Earth and fault dynamics Containerizing SCOPED software Once SCOPED-participating codes are mature (and meet best practices), we will containerize them for use on HPC systems and cloud systems, as sketched in the figure below left. These containers will be used both for research and training purposes. Zoom snapshot of a slide shown on Day 1 of the MTUQ2022 virtual workshop [April 2022]. The slide features the simultaneous | poster |
JobManagement Slurm Light-weight Grid Computing for Small Group Use Cases Aiqiang Zhang, Qimin Zhou, Xu Deng, Benda Xu Department of Engineering Physics, Tsinghua University zhangaq19@mails.tsinghua.edu.cn CHEP, 4-8 November 2019 1. Introduction In modern physics experiments, data analysis need considerable computing capacity. While several largescale grid solutions exist, for example DiRAC (Distributed Infrastructure with Remote Agent Control) [1], there are few schemes devoted to solve the problem at small-scale. For the cases when light-weight grid computing is more desirable, our project provides a simple solution in connecting and managing the distributive computing resources of a small group. The components are all freely available as official Debian packages. [1] Fifield, Tom, et al. "Integration of cloud, grid and local cluster resources with DIRAC." Journal of Physics: Conference Series. Vol. 331. No. 6. IOP Publishing, 2011. [2] Juliusz Chroboczek. The Babel Routing Protocol. RFC 6126. Apr. 2011. doi: 10.17487/RFC6126. url: https://rfc-editor.org/rfc/rfc6126.txt. [3] ”Slurm Workload Manager”. 2019. Web. Oct 2019. https://slurm.schedmd.com/overview.html. [4] Ming Chen, Dean Hildebrand, Geoff Kuenning, Soujanya Shankaranarayana, Bharat Singh, and Erez Zadok. 2015. Newer Is Sometimes Better: An Evaluation of NFSv4.1. SIGMETRICS Perform. Eval. Rev. 43, 1 (June 2015), 165-176. DOI=http://dx.doi.org/10.1145/2796314.274584 2. Overview 2.1 Network: Overlay 2.2 Storage: NFS 2.3 JobManager: Slurm 3. Performance 4 Conclusions References Acknowledgements 5 Upcoming Research tinc and babel are installed in every nodes. network is fault-tolerated and has low latency. hosts in private network could be connected. NFS (Network File System) was developed to allow machines to mount a disk partition on a remote machine as if it were a local disk.[4] run NFS server on the storage sharing host run NFS client on the hosts which can mount the shared filesystem Slurm is an open source, fault-tolerant, and highly scalable cluster management and job scheduling system for large and small Linux clusters.[3] slurmd daemon runs on each computing node slurmctld daemon runs on management node Requirement: 1.distribute filesystem 2. job management 3. maintainable without support team limitation: 1. several hosts, number range 2~4 2. different hosts in private isolated network Network: Overlay Storage: NFS HOST1 HOST3 SLURMCTLD SLURMD HOST2 NFS client NFS server VFS(virtual File System) network 3.1 Network Performance 3.2 System Performance slurmctld slurmd slurmd ENVIRONMENT: • The system is setup with 2 hosts in different private network. • The NFS server and Slurm controller run on the same node. • Server CPU: 32 cores, Intel Xeon E5-2630 • Client CPU: 16 cores, Intel Xeon E5-620 Figure 6 shows a time cost comparison between local file copy and remote file copy. The different size of files cost different time to copy. Copying file use NFS need network transport, which leads to more time delay. Figure 7 shows an experiment to measure the data processing time using single core without Slurm, single core with Slurm, five cores with Slurm. In the experiment, the job is to process many waveform files (the waveform generated from PMT voltage readout). The NFS cost a lot of time in the whole system. It is faster to use Slurm on more cores than single core. A unified interface is achievable with a few available packages from popular GNU/Linux distributions. Compare NFS with other distribute filesystem. Find the best strategy to allocate jobs to reduce the delay from network. Compare performance with other grid solutions, such as DIRAC. This work is support by SRT (Student Research Training) of Tsinghua University. The whole project is mentored by Professor Benda Xu. Qimin Zhou and Xu Deng did the main part of this project with me. Figure 1: small scale group Figure 2: Concepts maps of our solution Figure 3: The overlay network Figure 7: Time d | poster |
The dataset can be downloaded at https://openneuro.org/datasets/ds004215 RESULTS 1. Data cleaning is a non-trivial step in curating FAIR datasets. 2. Systematically searching for data errors is better than incidentally discovering them.1 3. Documenting data decisions with reasoning is key to isolating the source of errors. Data curation of the NIMH Healthy Volunteer dataset Arshitha Basavaraj1, Eric Earl1, Travis Riddle1, Jeffrey D. Stout2, Anna M. Namyst2, Adam Thomas1, Allison C. Nugent2, Joyce Chung3 1Data Science & Sharing Team, NIMH, 2Magnetoencephalography Core Facility, NIMH, 3Office of the Clinical Director, NIMH TAKEAWAYS ●Resolving data problems once they have occurred is referred to as data cleaning.1 ●About 80% of the time preparing a dataset is spent on data cleaning.2 ●Here we share some curation good practices based on our experience curating the NIMH Healthy Volunteer dataset.3 INTRODUCTION METHODS ●Four types of data collected ○Online questionnaires ○Clinical Assessments ○Magnetic Resonance Imaging (MRI) ○Magnetoencephalography (MEG) ●Raw data was cleaned, and transformed to BIDS4-6 standard format using semi-automated scripts. All manual steps were documented to ensure reproducibility. ●Data cleaning phases can be divided into error detection, diagnosis and treatment. ●Errors were detected through exploratory analysis tools such as: ○Summary statistics ○Outlier detection ○Expected variable ranges ●Cleaning tabular data7 required the most effort due to ○Loss of data provenance1,8 ○Manual data entry8 errors 1. Compile a version-controlled list of participants for each type of data. 2. Maintain a change log to document modifications to data collection processes. 3. Communicate frequently with study collaborators to speed up discovery and correction of data inaccuracies. 4. Allocating resources to monitor and clean data at every stage of data flow can greatly reduce errors. RECOMMENDATIONS Scan the QR code for references and other links or visit: See also posters: ➔#1283 for more specifics on the study protocol. ➔#2464 for the phenotype standardization software tool. linktr.ee/arsh.b Fig. 1: Flow of data from collection to sharing. Fig. 2: Phases of data cleaning Detect Diagnose Fix | poster |
A Schoolyard to Play H. Guerra1, N. Cortes1, C. Santos1, students from class 4.º I1 1Escola Básica da Quinta dos Franceses, Agrupamento de Escolas Dr. António Augusto Louro, Seixal, Portugal Abstract This is an entrepreneurship project that promotes awareness, as its main action is to make the school more appealing. Students have raised this problem, and identified the main goal of improving the schoolyard spaces. Problems were surveyed and solutions presented, with the focus of intervention in green spaces, new paintings and organization of leisure spaces. Contacts were initiated with different stakeholders, for the potential implementation of the solutions found in this project. Keywords Awareness; biodiversity; cooperation; entrepreneurship; responsibility; schoolyard. | poster |
I SIMPOSIO DE OBSTETRICIA CON ÉNFASIS EN LA SALUD MATERNA Y NEONATAL REVISIÓN SISTEMÁTICA: OBSERVACIONES DE LOS COMITÉS DE ÉTICA A PROTOCOLOS DE INVESTIGACIÓN MÉDICA Cristhian Vasco-Toapanta 1, Alisson Guanoluisa-Vasco 2, Gabriel Vasco-Toapanta3 1Interno Rotativo, Colegio de Ciencias de la salud, Universidad San Francisco de Quito, Quito, Ecuador 2Estudiante, Carrera de Fonoaudiología, Facultad de Ciencias de la Discapacidad, Universidad Central del Ecuador, Quito, Ecuador 3Estudiante, Ingeniería Civil, Colegio de Ciencias e Ingenierías, Universidad San Francisco de Quito, Ecuador Introducción: 1. Autonomía: Los pacientes eligen libremente participar, con protección para quienes no pueden decidir y consentimiento informado. 2. Beneficencia: Se maximizan los beneficios y se protege al paciente, evitando cualquier daño. 3. Justicia: Garantiza que los beneficios de la investigación se distribuyan de manera equitativa y que la selección de participantes sea justa. Metodología: Revisión sistemática de 9 estudios, incluidos estudios transversales, cohortes retrospectivas y estudios descriptivos, abarcando diversas regiones y tipos de investigación. Resultados Figura 1 Discusión: Hay disparidades significativas entre regiones y tipos de estudio, probablemente debido a diferencias culturales, interpretativas y en los recursos humanos e institucionales disponibles. Los CEIs deben mejorar sus procesos de evaluación para asegurar una selección justa, respeto por la autonomía y maximización de los beneficios, minimizando al mismo tiempo los riesgos para los participantes. Conclusión: El estudio destaca la necesidad de reforzar las prácticas éticas en la investigación médica, centrándose en mejorar el cumplimiento de principios fundamentales como la justicia, Referencias: Vasco-Morales, S., Vasco-Toapanta, G. A., Vasco-Toapanta, C. S., & Toapanta-Pinta, P. (2024). Ethics in medical research: A quantitative analysis of the observations of Ethics Committees in research protocols. MedRxiv, 2024.06.23.24309373. https://doi.org/10.1101/2024.06.23.24309373 | poster |
www.ikts.fraunhofer.de © Fraunhofer IKTS HOW TO INVESTIGATE ADDITIVE-RELATED EFFECTS FROM MICROPLASTICS? Annegret Potthoff1, Axel Müller-Köhn1, Anita Jemec Kokalj2, Dana Kühnel3 1Fraunhofer Institute for Ceramic Technologies and Systems IKTS, Dresden, Germany; 2University of Ljubljana, Ljubljana, Slovenia; 3Helmholtz-Center for Environmental Research GmbH – UFZ, Leipzig, Germany Contact: Annegret Potthoff | Fraunhofer Institute for Ceramic Technologies and System IKTS | Department Materials and Process Characterization | Group Powder and Suspension Characterization | Winterbergstrasse 28, 01277 Dresden, Germany | Phone +49 351 2553-7700 | annegret.potthoff@ikts.fraunhofer.de INTRODUCTION When assessing potentially harmful ecotoxicological or toxicological effects of microplastics, researchers are in a quandary: To suit the requirements of interpretable experimental data, they wish well characterized small particles, ideally with a narrow particle size distribution and ideally doped with a well detectable element like Europium. The wished polymer particles should not contain any other substances. To obtain results that represent real exposure scenarios, the characteristics of the test material are completely different: Microplastics found in the environment, differ in sizes and shapes – and they do not only contain the polymer itself, but an unknown quantity of unidentified chemicals. An approach that combines both, well-known characteristics and environmentally relevant properties, should be developed. The sample preparation procedure should work not only for a variety of polymers and chemicals, but also for different organisms. AIMS AND HYPOTHESIS To bring both – researcher´s needs and a relevant scenario – together, a defined sample preparation of close-to-reality particles under controlled conditions is required. For this, a polymer, "almost free" of chemicals, is needed, and chemicals, that are relevant for various applications, as well as organisms for ecotoxicological testing must be selected. A case study based on Low-density Polyethylene (LDPE) as widely common polymer, available as granules, was conducted. The filler Zinc Oxide (ZnO) was chosen because it acts as flame retardant for polymers. For the ecotoxicological tests, effects are expected: Due to leaching of Zinc ions when ZnO is exposed to water, the filler containing polymer particles could exert a higher toxicity than the control polymer particles. Figure 1: Compounding and extrusion of polymer tapes containing organic and nonorganic additives at Fraunhofer IKTS. Figure 5: Unknown quantity of unidentified chemicals – to be considered for ecotoxicological testing. ACKNOWLEDGEMENTS PlasticsFatE has received funding from the European Union’s Horizon 2020 Research and Innovation programme, under the Grant Agreement number 965367. CONCLUSIONS AND OUTLOOK Here we present an approach of using well-known additives in known concentrations in polymer particles for ecotoxicological testing. The described procedure opens the opportunity to assess the impact of additive compounds and polymer particles on organisms independent as well as in combination. The accompanied characterization work depends on type of the chemicals in polymer (Figure 5). A detailed understanding of mechanisms is required. Mixtures of chemicals can be tested in the same way. It can be combined with aging protocols to mirror environmental conditions – polymer particles might be tested before and after ageing. EXPERIMENTAL APPROACH - POLYMER SAMPLE PREPARATION Three steps of sample preparation were applied to produce well-defined particle for testing: Extrusion of tapes (Figure 1): In a first compounding step polymer and additives were mixed and granulated. This granulated feedstock was used in film extrusion process to produce endless tape, which can be separated in specific dimensions. 5 wt.% of ZnO were homogenously distributed in LDPE. Cryo-Milling (Figure 2): The milling bowl wa | poster |
[PO4-131] Artificial Intelligence applications in Personalized Nutrition Vassilios Solachidis, Kosmas Dimitropoulos, Lazaros Gymnopoulos, Dimitris Konstantinidis, Thomas Theodoridis, Petros Daras Information Technologies Institute, Cente for research and technology Hellas, Thessaloniki, Greece INTRODUCTION: Recent advances in Artificial Intelligence (AI) resulted in a multitude of applications of this technology in a wide range of fields. At the same time, the extensive use of smartphones and smart devices, which are equipped with a large variety of sensors, allows for capturing and analysis of numerous personal health related data by the user himself. In this work, we will provide an overview of the algorithms and applications – related to personalized nutrition – that are developed by the authors, including methods performing food identification, eating analysis and meal planning and recommendations. METHODS: The proposed food identification method can be applied to identify a certain food and its ingredients using only a single photo (of the food) captured with a standard mobile phone camera. The method is based on a deep learning neural network that employs Variational Autoencoders and is trained with a large database of a million images. The eating analysis method can be applied to analyse a video captured by a mobile phone and identify when someone bites and hence calculate his eating rate. This method initially uses a deep learning network that extracts body and face features from each video frame and, then, a second one that uses the extracted features and identifies the frames in which bites occur. Finally, the meal planning method can be used to propose personalised meal plans, based on expert knowledge (ontology), the user’s health profile, physical activity, food intake as well as the user’s preferences. RESULTS: Eating analysis method has been tested with real users achieving results similar to the manual annotation while food identification method outperforms the state of the art. Meal planning and recommendation algorithm is currently being tested using promising results. CONCLUSION: In this work three types of applications of AI in personalised nutrition have been presented. The eating analysis method is significant, especially for people with eating disorders, since it can identify abnormal eating rates and notify the user/ her/his medical doctor. The food identification method can be used as a component in nutrition applications, enabling the user to log his food intake in an easy and fast way. Even though it does not reach very high accuracy (despite being at the state of the art), it can however be used in a semi-automatic setup. Finally, using the meal planning method a user can improve her/his dietary health and, thus, achieve optimal health. 1. Conflict of Interest: None 2. Funding: This work was supported by the European Project: PROTEIN Grant no. 817732 within the H2020 Research and Innovation Programme. Keywords: artificial intelligence, deep learning, personalized nutrition, meal planning and recommendations, Details Status : Accepted:Poster sessions Presentation Type : Oral Presentation Abstract Category/Topic : Management and Intervention » Behavioural and lifestyle interventions Language : English Saved: : 25.01.2020 07:43:55 Submit: : 26.01.2020 21:02:35 Con¦dential to Author and Editor Presenter : Vassilios Solachidis (vsol@iti.gr) Close Print | poster |
References [1] W. Karlen et al., “Multiparameter respiratory rate estimation from the photoplethysmogram”, IEEE Trans Biomed Eng., vol. 60, no. 7, pp. 1946–53, Jul. 2013. [2] C. Orphanidou et al., “Data fusion for estimating respiratory rate from a single- lead ECG”, Biomed Signal Process Control., vol. 8, pp. 98–105, Jan. 2013. The Influence of Recording Equipment on the Accuracy of Respiratory Rate Estimation from the Electrocardiogram or Pulse Oximeter P. Charlton12 and T. Bonnici12, D. Clifton3, J. Alastruey1, L. Tarassenko3, P.J. Watkinson4, R. Beale12 1King’s College London 2Guy’s and St Thomas’ NHS Foundation Trust 3University of Oxford 4Oxford Biomedical Research Centre Summary: ECG, PPG and reference RR signals were acquired from 58 healthy adults. ECG and PPG signals were acquired simultaneously using: (i) laboratory equipment with minimal filtering, (ii) a routine clinical monitor, and (iii) a routine wearable pulse oximeter. There were no significant differences in the accuracy of RR estimates derived from the routine and laboratory equipment when using any of the five estimation methods applied to the ECG, and only when using one of the five methods applied to the PPG. In conclusion, using unfiltered signals may not change the accuracy of RR estimates significantly. The null hypothesis, that filtering had no impact on accuracy of RR estimates was accepted, when using all but two of the estimation methods (Table 1). In one of these instances the filtered signals provided more accurate estimates (blue), and in the other the unfiltered signals gave higher accuracy (red). The accuracy of RRs estimated from PPG and ECG signals differed minimally between minimally filtered and routinely filtered signals in this healthy cohort. We found no evidence to suggest that more accurate RR estimates could be obtained from unfiltered signals in this cohort. Patient monitors filter electrocardiogram (ECG) and pulse oximeter (PPG) signals prior to output. Would respiratory rate (RR) estimates derived from these signals be more accurate if unfiltered signals were used? Fig. 2: Respiratory Modulations Fig. 1: Diminished modulation after filtering PPG and ECG signals were band-pass filtered (6 – 60 rpm). AM and FM signals were extracted as shown. BW was extracted by decimating the signals to 5 Hz using a low-pass filter below 50 rpm. Only high quality 30 s windows were used. Table 1: The median (quartiles) subject-specific RMSEs of RR estimates derived from ECG and PPG signals. RR was estimated in the time and frequency domains from the three respiratory modulations: AM, FM and BW (as shown in Fig. 2). Signal Acquisition: 42 young (18-40 years), and 16 elderly (≥ 70) healthy volunteers took part. Minimally filtered PPG and ECG signals were acquired using laboratory equipment. Filtered signals were acquired from a tethered monitor. Filtered PPG was also acquired from a wireless monitor. Reference RR was obtained from oronasal airflow and chest impedance signals. RR Estimation: Breaths were detected from the respiratory modulations (Fig. 2) in the time- domain using 3-point peak detection. In the frequency- domain, the RR was identified as the frequency with the maximum FFT power within 6-40 bpm. Statistical Analysis: The null hypothesis, that the difference between RMSEs obtained using laboratory and routine equipment is zero, was tested using the paired, two-sided Wilcoxon signed rank test at 5% significance level. Contact T. Bonnici and P.Charlton contributed equally to this work: Peter.Charlton [at] kcl.ac.uk Timothy.Bonnici [at] ndm.ox.ac.uk RR is a sensitive sign of clinical deterioration. Current practice in most UK general hospital wards is to measure RR by manually counting chest movements over approximately 30 s. However, this has been shown to be inaccurate. RR can now be estimated automatically from the PPG [1] using filtered signals from wireless sensors. RR can also be estimated from the ECG [2]. It may be possible to obtai | poster |
Samuel Grunblatt1, Nicholas Saunders2, Daniel Huber2,3, Daniel Thorngren1, Shreyas Vissapragada4 1. Department of Physics and Astronomy, Johns Hopkins University, 2. Institute for Astronomy, University of Hawaii, 3. Sydney Institute for Astronomy, University of Sydney, 4. Center for Astrophysics | Harvard & Smithsonian An unlikely survivor: A low-density, hot Neptune orbiting a red giant star A targeted visual search for giant planets transiting giant stars with the giants pipeline (Saunders+ 2022) revealed a shallow (~400 ppm), long-duration (~9 hr) transit signal at a 4.2 day period. This signal was not found by other pipelines until 120-second cadence TESS data was available and a SPOC light curve was produced. An atmosphere saved by re-inflation? Key Points A needle in the haystack The first hot Neptune with an evolved host ❖The shallow, long-duration transit signal of this planet could initially be found only with the giants FFI pipeline, but has now been confirmed with a high-cadence, SPOC light curve detection and ground-based RV followup. ❖With a mass of 19.2 +/- 4.2 Earth masses and 6.2 +/- 0.8 Earth radii, this is the first hot Neptune found around an evolved star. ❖ The planet is predicted to have lost ~65% of its mass to atmospheric mass loss, which should have stripped its atmosphere entirely, unless the star was unusually inactive, or the planet experienced late-stage migration and/or re-inflation. Using exoplanet (Foreman-Mackey+ 2018), we modeled the available data for this system to determine the planet mass and radius. References 1. Saunders, N., Grunblatt, S., Huber, D., Collins, K., Jensen, E., et al. “TESS Giants Transiting Giants. I. A Noninflated Hot Jupiter Orbiting a Massive Subgiant,” AJ, 163, 53, 2022. 2. Foreman-Mackey, D., Luger, R., Agol, E., Barclay, T., Bouma, L, et al. “exoplanet: Gradient-based probabilistic inference for exoplanet data and other astronomical time series,” JOSS, 2021. 3. Watson, A.J., Donahue, T.M., Walker, J.C.G. "The dynamics of a rapidly escaping atmosphere: Applications to the evolution of Earth and Venus,” Icarus, 48, 150, 1981. Integrating the XUV flux expected for this and all other well- characterized planets with ages, we determine the cumulative expected atmospheric mass loss as a fraction of total planet mass. This planet is expected to have lost 65% of its mass, more than any other gaseous planet, despite models suggesting the atmosphere is only 20-30% of the planet mass (Lopez & Fortney 2014, Chen & Rogers 2016). How did this planet retain its atmosphere? Subsequent Keck/HIRES RV followup detected a signal at the same period and phase as giants and SPOC. Taking stellar parameters into account, we found that this is the first well-characterized hot Neptune known orbiting an evolved star. Rp = 6.21 +/- 0.76 REarth Mp = 19.2 +/- 4.2 MEarth Atmospheric mass loss depends on the planet density (Watson+ 1981): Thus, if the planet’s density was higher in the past, it can retain significantly more atmosphere. A 16% reduction in early planet radius results in a 50% reduction in atmospheric mass loss, allowing this planet to survive. 0 2 4 6 Age (Gyr.) 4 5 6 7 8 Radius (R©) Re-inflation Mass Loss 16% difference in radius at 1 Gyr = 50% difference in mass loss rate! Link to arXiv: https://arxiv.org/abs/2303.06728 (or use QR code above!) | poster |
Introduction Hepatitis B Virus (HBV) interaction with the immune system is a key determinant of infection outcome1. However, efforts to identify relevant circulating biomarkers of liver immune status have been disappointing. As the HBV field advances towards novel therapies (including immunoregulatory drugs)2, enhanced risk stratification, and cancer prevention, there is a pressing need to better understand the immunological profiles that underlie diverse disease outcomes3.We set out to compare circulating levels of ten cytokines, alongside host and viral biomarkers, in people living or not with HBV, based in the United Kingdom (UK), in order to develop new approaches to surveillance and risk stratification. Contrasting immune fingerprints of adults living with chronic Hepatitis B Virus infection, compared to non-infected individuals, from the UK Marion Delphin1, Gavin Kelly1, Elizabeth Waddilove1, Joshua Gahir1, Louise O Downs2,3, Sheila Lumley2,3, Catherine De Lara2, Sue Wareing3, Polyxeni Fengou3, Jacqueline Martin4, Tongai Maponga5, Monique Andersson2,3, Emma Wall1, Paul Klenerman2, Eleanor Barnes2,4, Azim Ansari2 and Philippa C Matthews1,6,7 Conclusions Adults living with HBV in the UK have a distinct immune profile that distinguishes them from matched adult controls. GM-CSF, IFNα2a, IL-2 and IL-10, PD-1 and TNFα seems to be the main modulated cytokines, with no covariance with known host parameters. In the CHB cohort, lower IL-2 and IL-10 was associated with a decreased HBV DNA, mostly attributed to treatment status. Further studies wiht increased numbers of individuals are needed to unravel these immune phenotypes. Developing insights into immune biomarkers may help us to develop enhanced understanding of the mechanisms that determine infection outcomes and treatment response, support better patient-stratification and guide evidence-based interventions. 1 The Francis Crick Institute, 1 Midland Way, London, UK 2 Nuffield Department of Medicine, Medawar Building for Pathogen Research, University of Oxford, Oxford, UK 3 Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Headley Way, Oxford, UK 4 Department of Hepatology, John Radcliffe Hospital, Headley Way, Oxford, UK 5 Division of Medical Virology, Stellenbosch University / Tygerberg Academic Hospital, Cape Town, SA 6 Division of Infection and Immunity, University College London, London, London, UK 7 Department of Infectious Diseases, University College London Hospital, London, London, UK Contact Informations: Marion Delphin: marion.delphin@crick.ac.uk @MarionDelphin Philippa Matthews: philippa.matthews@crick.ac.uk @pippa_matt Methods Cohort description: Adult living with HBV were enrolled at Oxford University Hospitals, UK (n=60), and age/sex matched non-infected adults were enrolled in the Legacy Study, London, UK (n=60) Patient meta-data were recorded at the time of recruit- ment, supported by Electronic Patient Records where available. Serum Sample Analysis: Liver Biomarkers: ALT/Fibroscan score HBV Biomarkers: HBsAg, HBeAg, HBV DNA Cytokines: GM-CSF, IFNα2a, IL-2, IL-6, IL-8, IL-10, IL-21, IP-10, PD-1 and TNF-α (multiplex ELISA, MSD) Statistical Analysis Using a euclidean distance, samples were hierarchically clustered based purely on stand- ardised log-transformed cytokine measure- ments using Ward's method for linkage. P values were calculated using Mann Witney or Chi-Squared test in Prism v. 8.0. **P ≤ 0.01; ***P ≤ 0.001; P ≤ 0.0001. References 1 M.Maini et al, Nat Rev Gastroenterol Hepatol; 2019 2 J.Feld et al, Clin Gastroenterol Hepatol, 2023. 3 A.Gehring et al, J.Hepatol, 2022. Results 3 Figure 2: Log-standardised heatmap representation of NI and CHB individuals Age 70 60 50 40 30 Sex Female Male HBV status CHB NI Color code Results 2: Result 1 We compared the immune profile of two cohorts of CHB and NI individuals that are age and sex-macthed, using quantification of a panel of 10 cytokines. The CHB cohort is dominated by an increase | poster |
Let's Turn the Lights Off to Turn the Stars On G. A. Pinto1, students from classes 7.ºD, 8.ºD and 9.ºD (school year 2017/2020) 1 1Escola Secundária/3 Camilo Castelo Branco, Agrupamento de Escolas Camilo Castelo Banco, Vila Real, Portugal Abstract In this project, the causes and consequences of light pollution were discussed. The students concluded that light pollution is not only responsible for the “disappearance” of the starry sky in cities, but also a threat to living beings and a huge waste of energy. They also concluded that the measures to avoid light pollution are within the reach of citizens and municipalities and are based on the use of energy-efficient exterior lighting that directs light only downwards. Students shared their findings with the community and, at the same time, developed an interest in Astronomy, together with their families. Keywords Astronomy; ecological footprint; energy efficiency; light pollution; starry sky. | poster |
The Agricore project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Grant Agreement No. 816078 FOLLOW US! #Agricore www.agricore-project.eu info@agricore-project.eu Agent-based support tool for the development of agriculture policies The AGRICORE project is developing a novel tool for improving the current capacity to model policies dealing with agriculture by taking advantage of the latest progress in modelling approaches and ICT. Specifically, the AGRICORE tool is being built as an agent-based approach where each farm is to be modelled as an autonomous decision- making entity that individually assesses its own context and makes decisions on the basis of its current situation and expectations. This modelling approach will allow simulating the interaction between farms and their context at various geographic scales – from regional to global. The AGRICORE suite will be a highly modular IT architecture in which modules can be exchanged, improved, and updated by other researchers and reused in other solutions. The architecture will be defined in a way to allow making use of the high computing and flexibility capabilities of cloud infrastructures both at public (Amazon Web Services, Azure, Google Cloud) and private (VMWare, OpenStack, HyperV) levels and always with a strong focus on data security (allowing the definition of private and public sections). 1. ARDIT 2. Data extraction module 3. Data fusion module 4. Generator of synthetic populations module 5. Agent-based simulation module 6. External interface module 7. Model interaction modules 8. Impact assessment modules (IAM) 9. Policy environment module 10. AGRICORE interface module USE CASE #1 will focus on the ex-ante (2018-2020) and ex-post (2014-2017) analysis of the impacts of a regional measurement (M11) (new and maintained ecological exploitations) in the field of olive exploitations in Andalusia, being this region the world leader on olive oil production. USE CASE #2 will focus on the ex-ante (2019-2020) and ex-post (2014-2018) analysis of the impacts of a national level measurement (M10.1) (agri-environment-climate commitments) in the overall Polish agricultural system and specifically, on ecosystem services in the country. USE CASE #3 will focus on the ex-ante (2018-2020) and ex-post (2014-2017) analysis of the impacts of a national level measurement (M6.1) (Business start-up aid for young farmers) in the overall Greek agricultural system. POLAND ANDALUCIA GREECE Carlos Leyva Guerrero1, Konstadinos Mattas2, Myrto Pelopida3, Ioanna Deligkiozi3, Mario Veneziani4, Giorgia Eranio5, Piotr Baranowsk6, Alicia Arce7, César Díaz Barroso8, Ahmet Ali KOÇ9, Waldemar Bojar10, Nikolaos Tsiantis11 1 IDENER, ES, 2 AUTH, GR, 3 AXIA, DE, 4 UNIPR, IT, 5 STAM, IT, 6 IAPAS, PL, 7 AYESA, ES, 8 CAAND, ES, 9 AKD, TR, 10 UTP, PL, 11 EXE, GR AUTHORS | poster |
Tailoring PLA surface with anchor lipids to fabricate transmembrane protein-loaded nanometric bioresorbable platform. 1 IMEM-BRT Group, Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/ Eduard Maristany 10-14, Ed. I2, 08019 Barcelona, Spain 2 Barcelona Research Centre for Multiscale Science and Engineering, EEBE, Universitat Politècnica de Catalunya, C/ Eduard Maristany 10-14, Ed. I-S-1, 08019 Barcelona, Spain 3 Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, Warsaw 02-089, Poland ahammed.hussain.madhani@upc.edu @m_s_a_h_m_8_6 1. Introduction In biomedicine, bioresorbable sensors hold great promise due to their ability to breakdown and resorb after use. As a result, patients wouldn't have to undergo a second, potentially risky surgical procedure to have non-bioresorbable sensors removed. However, developing reliable, biodegradable sensors remains difficult. In order to create such platform for biosensing that can support artificial lipid bilayers and transmembrane proteins such ion channels as biomimetic models, this research was initiated with the overarching goal of mimicking the cellular environment. The well-studied channel-producing peptide gramicidin (gA)(1) served as a template for this work. Acknowledgements This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No.955643 3. Conclusions Self-assembly, alkaline hydrolysis, and surface activation were the three stages of development that yielded a functional bioresorbable platform. The lipid layers were anchored to the polymeric scaffold with poly(ethylene glycol)-cholesterol (Chol-PEG- NH2). Furthermore, electrochemical impedance spectroscopy (EIS) was employed to detect the transport of monovalent cations on the polymeric substrate using Gramicidin A (gA). These lipid- and transmembrane-protein-based biomimetic systems hold great promise for future biofiltration and biosensing technologies.(2) This research provides a novel bioinspired method for fabricating a completely bioresorbable and biocompatible platform. 1) Zhangfei Su et al. Electrochim Acta, 2017 343 ,364 372 2) Mohammed-Sadhakathullah et al. Int. J. Mol. Sci. 2023, 24, 10312. 3500 1500 -0.05 0.00 0.05 0.10 0.15 0.20 DAbsorbance (a.u) Wavenumber (cm-1) PLA-PEG-Chol PLA-EDC PLA-NaOD C=O Amide C-H -0.2 -0.1 0.0 0.1 0.2 0.3 0.4 -1.0 -0.5 0.0 0.5 1.0 1.5 2.0 PLA PLA-PEG-Chol PLA-PEG-Chol-DMPC PLA-PEG-Chol-DMPC-gA s / mC cm-2 E / V vs Ag|AgCl -1.0 -0.8 -0.6 -0.4 -0.2 0.0 0.2 0 5 10 15 20 25 30 35 40 PLA PLA-PEG-Chol PLA-PEG-Chol-DMPC PLA-PEG-Chol-DMPC-gA C / mF cm-2 E / V vs Ag|AgCl 1M 0 50k 100k 150k 200k 250k 300k 350k 0.0 500.0k 1.0M 1.5M 2.0M 2.5M 3.0M PLA PLA-PEG-Chol PLA-PEG-Chol-DMPC PLA-PEG-Chol-DMPC-gA Z'(Ohm) -Z''(Ohm) -1 0 1 2 3 4 5 2 4 6 Log Z/ Ohm -F/ deg Log F/Hz 0 20 40 60 80 100 PLA PLA-PEG-Chol PLA-PEG-Chol-DMPC PLA-PEG-Chol-DMPC-gA R1 R2 CPE1 CPE2 PLA-PEG-Chol-DMPC-gA R1 R2 CPE1 PLA-PEG-Chol-DMPC 0 50k 100k 150k 200k 0.0 300.0k 600.0k 900.0k PLA-PEG-Chol-DMPC-gA with Ca2+ Z'(Ohm) -Z''(Ohm) -1 0 1 2 3 4 5 2 3 4 5 6 7 0 20 40 60 80 100 PLA-PEG-Chol-DMPC-gA with Ca2+ Log Z/ Ohm Log F/Hz -F/ deg Cholesterol-PEG-Amine Anchor Lipid Au Self assembled monolayers (SAM) Poly (Lactic acid) (PLA) Surface modification Gramicidin 2. Results 3500 1500 0.00 0.05 C-H C=O DAbsorbance (a.u) Wavenumber (cm-1) PLA-PEG-Chol-1H PLA-PEG-Chol-2H PLA-PEG-Chol-4H Fig 1. Change in the frequency w.r.t time Different lines correspond to 3,5,7,9,11 harmonics. Quartz Crystal Microbalance (QCM-D) ❑The quartz crystal microbalance (QCM-D) can spot changes in mass per unit area as little as a nanogram. Accordingly, as mass is added to the surface, the frequency decreases. Electrochemistry A B C D E F G Fig 4. Electrochemical characterization of PLA after every step (A-D) (A). Potential of Zero charge. (PZC) (B). AC Voltammetry (ACV) and (C,D). | poster |
Typischer collared rim storage jar der Eisenzeit I (Tall Zir¯a a). Westjordanlandes (Israel), wo dieser Bautyp zun¨achst entdeckt wurde, gegen¨uber dem Ostjordangebiet (Jordanien). Zu : Die collared rim storage jars (Abb. ) sind eine Form der Gebrauchskeramik, die f¨ur den pal¨astinischen Kulturraum typisch war. An der Wende zur Eisenzeit traten sie geh¨auauch im Ostjordanland auf. Sie wurden dort ebenso hergestellt und genutzt wie im zentralen Bergland westlich des Jordan. Ohnehin sind sie nicht als Neusch¨opfung durch neu eingewanderte Siedler im pal¨astinischen Bergland (die die Israeliten und Jud¨aer auch nicht waren) anzusehen, sondern stehen deutlich in einer sp¨atbronzezeit- lichen Tradition.13 Zu : Kreisf¨ormig bzw. elliptisch angelegte Berglandsiedlungen (enclosed settlements) hatte Israel Finkelstein14 als Indikator israelitischer und jud¨aischer Siedler vorgeschla- gen (Abb. ). Viele Forscher folgten ihm, zumal er zeigen konnte, dass w¨ahrend der Eisenzeit I viele nachmalig israelitische Gebiete mit derartigen d¨orflichen Siedlungen ausgestattet waren. Doch selbst Finkelstein musste schließlich feststellen, dass auch 13 Fritz , . 14 Finkelstein , –. Die Amazonen fallen ins attische Land ein. Attisch rotfiguriger Krater um v. Chr. Nach Steinhart , . konnte so f¨ur bestimmte Teile der attischen Landbev¨olkerung Ankn¨upfungspunkte bieten, ohne dass diese sich direkt mit den Amazonen h¨atten identifizieren m¨ussen. Nach den Perserkriegen hatte sich aber die Einstellung gegen¨uber den barbari- schen Fremden grunds¨atzlich ge¨andert. Ein erster propagandistischer H¨ohepunkt die- ser Griechen-Barbaren-Dualit¨at war um v. Chr. erreicht.51 Hier treten nun neue Amazonenbilder auf, die sie als gef¨ahrliche Gegner der Griechen verbildlichen, die aggressiv ins Bild st¨urmen, so dass die Athener nur defensiv ihr Land, auf das sie den Fuß verteidigend stellen, sch¨utzen k¨onnen (Abb. ).52 Nun war die Figur der Antiope problematisch geworden. Noch einmal kommt sie auf einem Krater in Basel auf Seiten der Athener k¨ampfend zur Darstellung, allerdings bereits in untergeordneter Position unter den Henkeln (Abb. ).53 Die j¨ungste Darstellung der Antiope stammt aus der 51 Hall , –, –und passim. 52 Attisch rotfiguriger Kolonettenkrater des Ariana- Malers in M¨unchen, Antikensammlungen um v. Chr.: Beazley , Nr. ; Beazley , ; Bothmer , Nr. Taf. .; Steinhart , , , Kat. Abb. .; .; Koch, Börner und Busse , ; Beazley Archive Nr. . 53 Attisch rotfiguriger Volutenkrater in Basel, Antiken- museum und Sammlung Ludwig BS um v. Chr.: Beazley , Nr. ; Carpenter , ; Steinhart , Abb. .–; Beazley Archive Nr. . Die von uns bereitgestellten Digitalisate und Publikationen können nach dem Prinzip des Open Access schnell, kosten los und barrierefrei genutzt werden. Durch konsequentes digitales Publizieren von Forschungsergebnissen und die Bereit stellung digitalisierter Ressourcen tragen wir maßgeblich dazu bei, Einschränkungen abzubauen und den wissenschaftlichen Impact unserer Autorinnen und Autoren zu erhöhen. Durch die freie Verfügbarkeit unserer Publikationen kommen wir zudem der Verpflichtung nach, die mit öffentlichen Geldern erzielten Forschungsresultate rasch und in uneingeschränktem Zugriff zu veröf fentlichen. Gleichzeitig wahren wir mit einem Open-Content-Lizenzmodell die Interessen der Autorinnen und Autoren, die zu übertra genden Nutzungsrechte selbst zu definieren und ihre Forschungsinhalte weit zu verbreiten. BERLIN STUDIES OF THE ANCIENT WORLD EDITION TOPOI Genealogie und Migrations mythen im antiken Mittelmeer- raum und auf der Arabischen Halbinsel Almut-Barbara Renger Isabel Toral-Niehoff (eds.) ...ist Publikationsorgan und innovative Forschungs plattform des Exzellenzclusters 264 Topoi –The Forma | poster |
Ambulatory patients are monitored intermittently Clinical deteriorations of hospital patients must be recognised early to maintain patient safety and minimise treatment costs. Routine practice on UK wards is to measure physiological parameters intermittently every 4- 6 hours to aid recognition of deteriorations. Thus there may be a prolonged period of deterioration prior to recognition. Deteriorations may be detected earlier by continuous monitoring Wireless sensors, combined with risk prediction algorithms, may enable earlier detection of deteriorations by continuously monitoring physiology. However, such systems depend on reliable data acquisition. We assessed the proportion of patient stay for which continuous ECG and pulse oximetry data could be captured using wireless sensors. References [1] Bonnici T et al. Testing of wearable monitors in a real-world hospital environment: what lessons can be learnt? In Ninth international conference on wearable and implantable body sensor networks, 2012. Washington DC: IEEE, 2012; 79–84. Acknowledgements This research was supported by the EPSRC [Grant EP/H019944/1], the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre at Guy’s & St Thomas’ NHS Foundation Trust, and the NIHR Oxford Biomedical Research Centre Programme. The views expressed are those of the authors and not necessarily those of the EPSRC, the NHS, the NIHR or the Department of Health. Contact T. Bonnici and P.Charlton contributed equally to this work: Timothy.Bonnici [at] ndm.ox.ac.uk Peter.Charlton [at] gstt.nhs.uk Continuous Physiological Monitoring of Ambulatory Patients T. Bonnici12 and P. Charlton12, J. Alastruey1, L. Tarassenko3, P.J. Watkinson4, R. Beale12 1King’s College London 2Guy’s and St Thomas’ NHS Foundation Trust 3University of Oxford 4Oxford Biomedical Research Centre For what proportion of patient stay can continuous ECG and pulse oximetry data be captured using wireless sensors? 222 patients were monitored wirelessly during their recovery from cardiac surgery on a general ward. ECG data were acquired for the majority of patient stay, whereas pulse oximetry data were acquired for less than a fifth of the time. Furthermore, over a third of patients requested to stop wearing sensors. Therefore, there is room for improvement to the design of wireless sensors, particularly the pulse oximetry component. Method A post-surgical cardiac ward was equipped with wireless sensors which transmitted data to a central monitor in real time. 222 patients consented to wear a sensor whilst recovering from cardiac surgery. Results 196 patients wore a sensor (22 did not stay on the ward, 3 requested not to wear a sensor, and 1 was not given a sensor for clinical reasons). 122 wore a sensor until discharge, 66 requested to stop wearing the sensor early, 6 had the sensor removed for clinical reasons, and 2 were transferred elsewhere. The median length of ward stay was 4.5 days. The 196 patients wore sensors for 898 out of 1344 days. ECG and pulse oximetry data were acquired from each patient for 62% (52) and 18% (41) of their stay respectively. Conclusions ECG data were acquired for the majority of patient stay, whereas pulse oximetry data were acquired for less than a fifth of the time. Furthermore, over a third of patients requested to stop wearing sensors. Therefore, there is room for improvement to the design of wireless sensors, particularly the pulse oximetry component. Using wireless sensors for earlier detection of physiological derangements than routine observations. Patients’ tolerance of wireless sensors is unknown In a previous assessment of patients’ tolerance of wireless sensors, none acquired data consistently for 24 hours [1]. Therefore, wireless sensors which are routinely used in the NHS were chosen for this study. Whilst more cumbersome than state-of-the-art sensors, they may be more reliable. Future Work This trial aims to determine the proportion of physiological derangem | poster |
ABSTRACT Proteogenomic searches allow the identification of protein variants by extending canonical protein sequence databases with the predicted product of genomic variation. In this study, we investigate how including germline sequence variants influences the scoring and yield of proteogenomic searches. Then, we show how the peptides distribute relatively to their predicted retention time and fragmentation. By combining these features, we anticipate proteogenomic pipelines to enable the calling of genetic variants in proteomics data, which in turn will be helpful for the analysis of their consequences and pathogenicity. How including germline sequence variation influences the search space in proteomics Dafni Skiadopoulou1, Jakub Vašíček1, Ksenia Kuznetsova2, Pål R. Njølstad1,3, Stefan Johansson1,4, Lukas Käll5, Marc Vaudel1 ACKNOWLEDGEMENTS This project is supported by the Research Council of Norway (project #301178). 1Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway 2Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia 3Children and Youth Clinic, Haukeland University Hospital, NO-5020 Bergen, Norway 4Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway 5Science of Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology – KTH, Stockholm, Sweden Fig. 1: Proposed proteogenomics pipeline. Fig. 2: Posterior error probability density (left) and number of peptide-spectrum matches at a given q-value (right) for searches using the UniProt database and the extended protein sequence database. REFERENCES [1]Umer, H.M., Zhu, Y., Pfeuffer, J., Sachsenberg, T., Lehtiö, J., Branca, R. and Perez-Riverol, Y., 2021. Generation of ENSEMBL-based proteogenomics databases boosts the identification of non-canonical peptides. bioRxiv. [2]Bouwmeester, R.; Gabriels, R.; Hulstaert, N.; Martens, L.; Degroeve, S. DeepLC Can Predict Retention Times for Peptides That Carry As-yet Unseen Modifications. Nat. Methods 2021, 18, 1363–1369. [3]Sven Degroeve, Lennart Martens, MS2PIP: a tool for MS/MS peak intensity prediction, Bioinformatics, Volume 29, Issue 24, 15 December 2013 [4]Käll, L., Canterbury, J. D., Weston, J., Noble, W. S. & Mac Coss, M. J. Semisupervised learning for peptide identification from shotgun proteomics datasets. Nature Methods 4, 923–925 (2007). [5] Wang, D. et al. A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. Mol. Syst. Biol. 15, e8503 (2019). RESULTS ❖Including variants in the protein database increases sequence redundancy and reduces the yield of peptide identification (Fig. 2). ❖The retention time and fragmentation features show outlying peptides that are assigned a high confidence score by Percolator but show a large difference between the measured and the predicted values (Fig. 3 and 4). ❖Decoys distribute differently from targets in the space defined by agreement with retention time and fragmentation with prediction (Fig. 5). Variant peptides confidently identified by Percolator show a high prevalence of outliers in both retention time and fragmentation (Fig. 5). Fig. 4: Predicted vs. observed retention time of the peptide-spectrum matches obtained by searching in the UniProt database (left) and the extended protein sequence database (right). Fig. 3: Density of the retention time (left) and fragmentation (right) for all peptide-spectrum matches using the UniProt database and the extended protein sequence database. METHODS Protein sequence database created with py-pgatk[1]: ●canonical proteome ●variants with minor allele frequency > 1% (Ensembl, no population filter) ●variants acquired from exome sequencing of the studied tissue samples ●common sample contaminants Peptide features agreement with predictors: ●Retention time using DeepLC[2]: distance evaluated using a linear model ●Fragmentation using MS2PIP[3]: spectral log-distance Identificat | poster |
VisualizingHealthcareSystemDynamics(HSD)inBiomedicalBigData Acknowledgements Biomedical Big Data, such as electronic health records (EHR) and administrative claims, are records of patients’ interactions with the healthcare system; for example, the date of a diagnosis is when a physician entered the code into the EHR, not when the patient developed the disease. Most researchers are either unaware of the distinction or naively treat it as noise. However, using data visualizations, we show that these subtle effects of the healthcare system on observational clinical data actually contain valuable information that could benefit biomedical research, clinical care, and health care policy. NickBenik1;KatyBorner,PhD2;NickBrown1;DanielHalsey2;IsaacKohane,MD,PhD1;GriffinWeber,MD,PhD1 1HarvardMedicalSchool;2IndianaUniversityhttp://HealthcareSystemDynamics.org AddingHSDtothei2b2Platform Abstract This work was conducted with support from National Institutes of Health, National Cancer Institute, RFAͲHGͲ14Ͳ020, Targeted Software Development: Data Visualization, Grant Number 1 U01 CA198934Ͳ01. PrototypeVisualizations 3DWLHQW3DWKRSK\VLRORJ\ +HDOWKFDUH6\VWHP'\QDPLFV 1RUPDO $EQRUPDO 1RUPDO +LJKHVW6XUYLYDO 0RGHUDWH6XUYLYDO $EQRUPDO 0RGHUDWH6XUYLYDO /RZHVW6XUYLYDO 3DWLHQW3DWKRSK\VLRORJ\ +HDOWKFDUH6\VWHP'\QDPLFV 'DWD4XDOLW\ 3DWLHQW'HPRJUDSKLFV 'LDJQRVHV /DERUDWRU\7HVW5HVXOWV 9LWDO6LJQV *HQHWLF0DUNHUV 1XPEHURI2EVHUYDWLRQV 7LPHRI'D\RI2EVHUYDWLRQV 7LPH%HWZHHQ2EVHUYDWLRQV &RVWRID7HVWRU7UHDWPHQW &OLQLFDO6HWWLQJ&OLQLFLDQ7\SH 'DWD(QWU\(UURUV 'LFWDWLRQ0LVWDNHV 'DWD&RPSUHVVLRQ/RVV 8QVWUXFWXUHG'DWD 0LVVLQJ'DWD Hypothesis Every observation in EHR data combines both patient pathophysiology and healthcare system dynamics (HSD). Each predict patient outcomes. PredictingSurvivalUsingHSD The table indicates the fraction of patients alive 3 years after a white blood cell (WBC) test. Columns correspond to patient pathophysiology categories and rows correspond to HSD categories. An abnormally high WBC in the evening has a higher survival (85.74%) than a normal WBC in the morning (82.91%)! Lowest survival combines both abnormal patient pathophysiology and abnormal HSD. FactCountGrowthCurves Fact count is the total number of diagnoses, medications, procedures, etc. in a patient’s record. Fact count rate grows over time, but at different rates for different patients (blue curves). Patients with a normal fact count (50th percentile) have the highest 3 year survival. For example, a 70 yearͲold man with a median fact count has the same survival rate (90%) as a 45 yearͲold man in the 95th fact count percentile and a 58 yearͲold man in the 5th fact count percentile. 0DOH )HPDOH DerivingNormalLabValueRangesUsingHSD Clinicians repeat laboratory tests more frequently (an HSD variable) if the values are abnormal. As the values become more extreme, the variance in repeat interval across patients decreases. Thus, more clinically useful normal ranges for lab tests can be defined based physician ordering behavior. Subgroups of patients can also be identified from the HSD data (right, pediatric age groups). HSD concepts (e.g., fact count, day of the week, etc.) are added to the i2b2 ontology and can be used in queries in combination with patient pathophysiology concepts (e.g., diagnoses, lab values, etc.). Download from http://HealthcareSystemDynamics.org PatientSurvivalbyWhiteBloodCell(WBC)CountandTimeofDay AgeandFactCountDistributionsofMultiplePatientCohorts This project integrates two widely adopted open source software platforms for querying clinical data repositories (Informatics for Integrating Biology and the Bedside, i2b2, https://www.i2b2.org) and developing modular data analysis and visualization tools (Science of Science, Sci2, https://sci2.cns.iu.edu). Below are screenshots of HSD visualizations built using these two systems. For more information visit htt | poster |
ACE-DATA: Delivering Added value To Antarctica Jenny Thomas1 (jenny.thomas@epfl.ch) and Julia Schmale2 1Swiss Polar Institute, Lausanne, Switzerland, 2Paul Scherrer Institute, Villigen, Switzerland. Polar2018, June 2018 ACKNOWLEDGEMENTS The Antarctic Circumnavigation Expedition was funded and made possible by the ACE Foundation and Ferring Pharmaceuticals. ACE-DATA is funded by the Swiss Data Science Center and the Swiss Polar Institute. REFERENCES Antarctic Master Directory, https://gcmd.gsfc.nasa.gov/KeywordSearch/amd/about_us.html Jupyter, http://jupyter.org/ Renku, Swiss Data Science Center https://datascience.ch/renku-platform/ air mass movement sea-spray primary aerosol trace gases ●DMS ●isoprene ●amines ●halogens secondary aerosol particles aerosol-cloud interactions precipitation evaporation Antarctica Southern Ocean catabatic winds microbial communites J.Schmale Open-access ACE data Swiss Polar Institute data portal Antarctic Master Directory (AMD) Digital Object Identifiers (DOIs) Subject-specific repositories RENKU RENKU Data in Data in Algorithms applied to data are recorded Data out Data out ACE data RENKU, developed by the Swiss Data Swiss Data Science Center (SDSC) Science Center (SDSC) allows users to: • View algorithms applied to data • Re-use and modify of code • Collaborate with Jupyter notebooks COLLABORATIVE DATA-SHARING PLATFORM What? What? Open-access ACE data available through a data-sharing platform. Why? Why? • Antarctic Treaty requires that all data collected south of 60°S is openly available. • Easier inter-project collaboration with data in a common format in one place. • Data are available to the international community to allow benchmarking of global change. INTRODUCTION INTRODUCTION Over 30 TB of data and almost 27,000 samples from a wide variety of scientific disciplines, collected simultaneously as part of the Antarctic Circumnavigation Expedition (ACE), offer us the unique opportunity of a holistic view of the Southern Ocean in the austral summer of 2016/17. The ACE- DATA: Delivering Added value To Antarctica project will provide a collaborative data-sharing platform and explore cross-disciplinary questions using data science techniques. ACE data summary ACE data summary - 90 days of measurements (20th Dec 2016 – 19th March 2017) - > 300 variables measured (ocean, atmosphere, land, ice, biodiversity) - continuous (down to 1 sec resolution), semi-continuous (~once a day) and discrete (event- based) measurements - in-situ, remote sensing and simulation data What? What? Antarctic Sea-Atmosphere Interactions Data (ASAID) project A subset of data from ACE will be used to explore air-sea interactions in the Southern Ocean using machine learning techniques. Why? Why? • Current models struggle to simulate Southern Ocean processes. • Interactions are still very unknown, yet influence clouds, radiation and climate worldwide. Approach Approach Data science methods are used to identify relationships between various sets of a small number of variables, followed by a statistical model that will be based on these relationships. Resulting information will be fed into coupled ocean-atmosphere models CROSS-DISCIPLINARY DATA EXPLORATION | poster |
The HST-JWST Transmission Spectrum of Ultra-hot Jupiter WASP-178b How: After reduction of the spectra with FIREFLy4 (see Figure 1), we then use the PETRA5 retrieval framework to measure the abundance of refractory and volatile elements (see Figure 2). We fit for the temperature structure, reference radius, offsets between instruments, and an opaque cloud layer alongside [(Fe+Mg+Si)/H], [O/H], and [C/H] in chemical equilibrium. [1] Hellier, C., et al. (2019), MNRAS, 480, 1. [2] Rodríguez Martínez, R., et al. (2020), AJ, 160, 3. [3] Lothringer, J. D., et al. (2022), Nature, 604, 7904. [4] Rustamkulov, Z., et al. (2023), Nature, 614, 7949. [5] Lothringer, J. D., et al. (2020a). AJ, 159, 6. [6] Lothringer, J. D., et al. (2021), 914, 1. @JDLothringer jlothringer@uvu.edu joshualothringer.faculty.uvu.edu What: We observed four transits of WASP-178b1,2 (Teq = 2450 K) from 0.2-1.7 µm with HST/WFC3 G280, G102, and G141 and JWST/NIRSpec G395H from 2.8 to 5.0 µm. In the NUV, SiO, Fe+, and Mg absorb over nearly 20 scale-heights.3 At IR wavelengths, absorption from CO and H2O is evident. References Results: Initial retrievals suggest sub-solar [O/H] and [C/H], sub-solar C/O, and approximately solar [Fe/H]. This tentatively implies the accretion of refractory and oxygen-rich material (e.g., silicate rock) into the planetary atmosphere. These retrieval results are very preliminary yet emphasize the informative nature of ultra-hot Jupiter spectra with respect to planet formation.6 Acknowledgements This work is based on observations made with the NASA/ESA-Hubble Space Telescope and JWST obtained at the Science Institute (Programs 16086, 16450, and 2055), which is operated by the Association Space Telescope of Universities for Research in Astronomy, Inc. FIGURE 2 – Posterior distributions for [Fe/H], C/O, [O/H], and [C/H] from PETRA using the combined HST-JWST transit spectrum of WASP-178b. These preliminary results suggest enrichment of the planet’s atmosphere by oxygen-rich rocky material like silicates (e.g., (Fe,Mg)xSiOy). Joshua D. Lothringer 1 2 (!) Zafar Rustamkulov3, David Sing3, Audrey Elison1, Neale Gibson4, Jamie Wilson5, Kevin Schlaufman3, Henrique Reggiani6 Affiliations 1) Utah Valley University 2) Space Telescope Science Institute 3) Johns Hopkins University 4) Trinity College Dublin 5) Queens University Belfast 6) The Observatories of the Carnegie Institution for Science Retrieval Results SiO, Mg, Mg+, Fe, Fe+ HST/WFC3/G102+G141 JWST/NIRSpec/ G395H H2O H2O, H- CO FIGURE 1 – Combined HST-JWST transmission spectrum of WASP-178b reduced with FIREFLy4 plotted with the best-fit spectrum from the retrieval with PETRA.5 Data points from different instruments have been shifted using offsets fitted for in the retrieval. HST/WFC3/G280 JWST/NIRSpec/ G395H H2O CO UV-O-IR Transmission Spectrum of WASP-178b Future: Determination of the stellar abundances is underway, with high-resolution spectra in-hand. Our retrieval results and modeling interpretation will further solidify. Expect a paper by the end of the year! A large population sample of UV-IR ultra-hot Jupiter transit spectra can help reveal the origin of giant planets. | poster |
Habitat edges affect stand diversity more than biomass regeneration in a wet neotropical secondary forest Nicholas Medina Ecology and Evolution, University of Michigan Biology and Environmental Studies, Brandeis University; Land Stewardship, Osa Conservation HIGHLIGHTS - Old plantations may facilitate wet tropical secondary forest regeneration - Aboveground biomass and light were resilient to edge effects across 300 m, while wood and stem density tended to increase across 300 m habitat edge - Diversity lowered non-linearly and community composition varied notably - Taxa associated with early- and late-stage succession tended to lose biomass - Future forests likely show some resilience in functions but not biodiversity INTRODUCTION Secondary forest regeneration - Forest and landscape restoration is a key international conservation and climate change adaptation strategy (De Pinto et al. 2020), and while tropical forests specifically store most land biomass (Pan et al. 2013), most are now secondary (FAO 2020) and regenerating degraded functions (Hubau et al. 2020) amid increasing climate stressors (Anderegg et al. 2022) yet insufficient policy support (Robin L. Chazdon 2018) via skewed priorities (Pyron and Mooers 2022). - Secondary forests can regenerate relatively quickly compared to old-growth forests in some ways, but in other ways remain distinct. - Neotropical secondary forests can grow quickly enough to accumulate biomass >10x faster than old-growth forests (Finegan 1996; Poorter et al. 2016), and substantially offset carbon emissions, with estimates ranging from ~10% from Amazonian deforestation (Smith et al. 2020) to a decade of fossil fuel emissions from all of Latin American and the Caribbean (R. L. Chazdon et al. 2016). - They also recover taxonomic richness and biomass quite quickly, as well as tree height, averaging 80% of old-growth forest levels in just 20 years, especially in wetter regions (Rozendaal et al. 2019). - The recovery of species richness alone is beneficial in that it also tends to correlate with the recovery of some ecosystem services (Guariguata and Ostertag 2001; Stanturf, Palik, and Dumroese 2014) like biomass and carbon storage (Liu et al. 2018). - However, secondary neotropical forests diverge widely in taxonomic composition (Norden et al. 2015), potentially taking over a century to recover (Poorter et al. 2021) with added variability (Atkinson et al. 2022). - Despite being one of the slowest ecosystem properties to recover, restoring recovering community composition is often important for preserving rare taxa (Carlo and Morales 2016), which can be keystone to locally-adapted food webs, including birds (Maas et al. 2016). - Understanding secondary forest regeneration is key for global biodiversity conservation at the global scale, yet local management remains the strongest driver of tropical forest carbon stores (Pyles et al. 2022). Edge effects - Secondary forest regeneration is often affected by edge effects, or changes near an ecosystem boundary, as well as land-use history, especially in heterogeneously-managed landscapes (Perfecto, Vandermeer, and Wright 2009; Melo et al. 2013). - About 70% of all forests have been estimated to be within a km of their edge (Haddad et al. 2015), resulting in tropical forests having been estimated to lose ~22% aboveground carbon along heavily-managed edges >100m, in part due to shortening trees and lighter leaf mass (Ordway and Asner 2020). - Edge effects also have the potential to shape community composition, based on the local dispersal kernel patterns of existing taxa (Wandrag et al. 2017), which while complicated (Muller-Landau and Hardesty 2009), can also correlate with simpler plant traits like height and seed mass (Thomson et al. 2011; Tamme et al. 2014). - The traits of existing taxa also depend on land-use history and previous management (Omeja et al. 2012), which historically has favored tree taxa that tend to pioneering, or be faster-growing, have lower wood | poster |
Use Cases Next-GENeration IoT sOlutions for the Universal Supply chain www.ingenious-iot.eu ingenious_iot @ingenious_iot ingenious_iot Automated robots with heterogeneous networks use case foresees the use of 5G-enabled multi-task automated robots in future smart factory production lines or warehouses, targeting the interoperability of wireless and wired environments and the tactile internet where sensors and actuators synchronously work with latencies of few milliseconds. Improved driver’s safety with Mixed Reality (MR) and haptic solutions is a safety-centric use case that foresees to remotely control transportation of goods with Automated Guided Vehicles using tactile internet, edge computing and immersive enablers (MR engines, haptic gloves). Employees will be safe, away from hazardous working locations such as fuel port terminals. Inter-modal visibility in the supply chain with containers use case aims to provide End-to-End (E2E)intermodal asset tracking with satellite connectivity for enabling enhanced real-time monitoring of shipping containers when they are sailing through oceans without connectivity to terrestrial IoT networks. Supply chain ecosystem integration use case overcomes the absence of a virtual interoperability IoT and DLT layer that will be capable of securely and semantically exchange the information flows between the different actors that can take part along the supply chain ecosystem. Transportation platforms health monitoring use case pursues the asset health tracking in order to decrease operational costs and increase asset availability with new data-based service provided by low-power edge distributed network and intelligent sensor modules installed in the transportation platforms. iNGENIOUS aims to design and evaluate the Next-Generation IoT (NG-IoT) solution, with emphasis on 5G and the development of Edge and Cloud computing extensions for IoT, as well as providing smart networking and data management solutions with Artificial Intelligence and Machine Learning. The project embraces the 5G Infrastructure Association (5G IA) and Alliance for Internet of Things Innovation (AIOTI) vision for empowering smart manufacturing and smart mobility verticals. Architecture MANAGEMENT AND SECURITY SERVICES SMART APPLICATIONS NETWORK THINGS AR/VR GEOLOCATION AI PRIVACY SECURITY DLT INTEROPERABILITY RADIO NETWORK EDGE NETWORK IT NETWORK SENSORS SOC ACTUATORS MODEMS Security and privacy ●At the Management and Security level: data interoperability with pseudonymization for handling personal data according to European General Data Protection Regulation (GDPR); data integrity using Distributed Ledger Technology ●At the Network level: security enhancements over previous 3GPP standards ●At the Things level: policy analysis and definition for Identity & Access management for 5G-connected IoT devices Artificial Intelligence and Machine Learning (AI/ML) ●At the Smart Application level: accurate prediction of arrival times for vessels at maritime ports optimisation of truck turn-around times in ports ●At the Network level: adapting the assignment of network resources to IoT devices ●At the Things level: data processing at the edge within energy-constrained IoT sensors Cross-layer Innovations in the iNGENIOUS Architecture Situational understanding and predictive models in smart logistics scenarios use case aims to integrate artificial intelligence to improve the access of vehicles to ports and reduce the waiting times, leading to corresponding savings on direct costs for carriers. | poster |
Computer vision methods for monitoring outdoor recreation and wildlife Rachel Shively, Ryan Sharp, and Sarah Jackson Park Management and Conservation, Kansas State University Method Coding Time Accuracy Notes Manual Timelapse2 ●●●●● ●●●●● 2.7 sec/photo ●●●●● Depends on observer Slow handling. Limited output options. No coding required. DigiKam (recommended) ●●●●● ExifTool required ●●●●● 2.1 sec/photo ●●●●● Depends on observer Tags attached to meta- data of photos for more output flexibility. Computer vision (pretrained models) YOLOv4 ●●●●● ●●●●● 2.6 sec/photo (computer time) ●●●●● Mislabeled multiple objects Less accurate in low light. Did not detect all objects. Simpler batch coding. Detectron2 (recommended) ●●●●● ●●●●● 0.7 sec/photo (computer time) ●●●●● Mislabeled wildlife and ORVs Detected all objects. Easier to train for improving accuracy. Smart camera Raspberry Pi4 ●●●●● Comes with tutorials ●●●●● Immediate once programmed ●●●●● Requires specific objective Programmed tasks required. Low-cost camera option. Good for detecting thresholds (e.g., full parking lot) or specific animal/object. YOLOv4 Performed well on daylight detections of domestic animals, people, and common objects when entire object was in frame Table 1. Selection of options for processing trail camera photos for analysis. Trail cameras are useful for collecting large amounts of data from multiple locations with minimal disturbance; however, analysis of resulting photos can be time-consuming. Computer vision can improve analysis efficiency. We tested manual and computer vision options to analyze a set of photos from trail cameras placed at Cimarron National Grassland in southwestern Kansas. Considerations • Access to all required software is free • Camera placement matters • Detectron2 could eliminate empty images prior to manual analysis • Many tutorials are available – GitHub, RoboFlow, MatLab($) • Training to improve accuracy requires a labeled set of images. Pretrained models are rapidly improving as more labeled datasets become available. Detectron2 Detected objects even in low light. Labeled wildlife as domestic species. Training to correctly label ORVs was accomplished in 54 minutes. | poster |
Northern Gallego Thrust (NGT) Northern Gallego Thrust (NGT) Poor outcrop and reforestation made it difficult to get measuerments Guara forms a topographical high, the ridgeline from WNW to ESE. Its beds are stronger than sorrounding formations Formations inferred in from localised peaks in topography and dip contrasts indicating possible faulting Outcrop between Guara and marl poor, however transistion characterised by sharp change in topography Talus slope of conglomerate phase visible in hillside looking east from the gorge 118 17 107 50 110 63 105 64 104 46 111 62 111 52 100 47 119 40 109 60 113 51 107 39 121 62 104 47 091 41 107 50 110 47 118 41 111 51 098 60 111 56 102 48 105 33 114 64 114 53 106 45 113 43 096 49 105 31 110 39 131 52 104 49 109 46 103 52 104 51 104 51 106 50 107 51 101 51 126 31 112 53 112 47 108 40 119 39 112 72 107 42 112 47 113 43 114 46 108 66 109 46 112 45 111 36 112 39 112 45 127 54 100 51 114 60 109 60 111 58 115 56 104 50 098 59 104 54 111 51 107 53 089 40 089 44 124 39 074 24 089 19 189 22185 36 129 44 137 32 100 27 094 40 094 42 184 22 189 29 137 50 103 52 097 44 080 56 103 61 129 31 102 57 122 19 135 35 120 39 109 31 107 34 110 23 105 33 117 52120 49 043 47 051 51 109 09 148 17 097 53 096 29 093 33 100 38 095 42 097 58 111 41 109 40 031 52 074 51 083 49 150 42 126 44 111 39 106 42 115 40 103 43 116 32 109 28 105 40 108 39 089 43 092 41 117 56 115 60 113 55 122 62 127 65 121 58 114 61 122 48 093 63 099 65 100 40 104 43 089 63 079 71 140 30 GLS GLS GLS AM AM AM AM CHL CHL CST CST 120 51 129 53 100 60 100 47 110 38 100 47 114 39 119 52 126 51 106 59 100 51 093 33 114 42 103 31102 41 173 44 177 35 129 40 128 48 138 44 131 43 135 42 118 54 098 50 106 62 128 48 042 31 036 28 193 43 029 28 052 19 022 21 134 80 082 60 073 46 070 26 070 26 082 30 046 29 000 27 025 26 069 31 020 31 015 23 010 21 072 90 111 31 106 62 113 22 150 50 081 63 199 43 183 39 168 87 176 87 145 70 147 66 104 42 135 19 126 78 138 22 130 21 120 35 111 31 124 44 119 38 201 20 305 70 158 36 136 42 081 63 135 61 131 62 041 42 064 36 143 90 090 41 107 43 087 61 093 32 079 03 083 02 094 04 083 02 086 39 099 29 042 49 055 46 019 42 097 37 091 39 116 39 106 51 188 69 183 86 109 42 123 38 086 72 081 66 084 69 082 43 CHL CST GLS AM AM CHL GLS GLS CST 185 07 111 37 109 41 113 48 095 49 098 62 098 64 093 54 132 32 123 37 119 39 098 57 082 53 100 66 101 76 091 72 064 53 033 51 135 72 025 51 032 54 093 54 342 26 348 30 014 29 001 24 008 27 340 33 344 36 344 36 332 50 023 19 015 15 TR TR TR ADB ADB ADB ADB ADB ADB ADB TR TR GLS AM 088 10 084 10 076 35 063 39 017 26 074 15 110 19 109 24 119 22 112 18 094 25 099 20 111 23 107 26 109 24 105 54 114 44 105 54 091 32 106 51 083 42 069 51 128 39 031 24 130 11 119 43 122 21 123 42 109 24 090 29 088 30 089 32 086 32 152 32 107 25 100 62 132 22 094 44 119 38 130 28 142 19 125 44 133 89 151 60 091 29 150 42 129 90 151 85 159 89 133 57 130 11 129 50 174 41 128 37 090 57 101 60 138 57 085 04 ADB ADB PDS SC SC SC PDS PDS PDS PDS SC CG1 CG2 CG3 CG4 CG5 CG3 GLS LNA LNA LNA CG2 Azoic silty and friable grey marls with no discernible bedding planes. Thin bands of laterally extensive Calcite exhibit slickenlines which are oriented downslip. | poster |
Mead Mead is an ancient alcoholic beverage made from fermented honey and water. Recently, mead has come back from the brink of obscurity and seen a global resurgence in popularity. Mānuka honey Mānuka honey contains the potent bioactive compound methyl glyoxal (MGO). MGO has significant and well- established antibacterial properties,1 and is responsible for mānuka honey’s international fame. High MGO-honey’s fetch premium prices in NZ and abroad. Mānuka mead… MGO? In previous qualitative studies, we’ve shown that MGO is not consistently preserved through the fermentation of mānuka honey mead – most of the time it doesn’t survive the fermentation process. To further probe this mechanism, a quantitative method was needed for its analysis. Quantitative method requirements • MGO has been quantified in mānuka honey – but never in mead. We set out to develop an HPLC method. • MGO requires derivatisation to be visible on an HPLC instrument. Two options for derivatising agents, PFBHA2 and o-phenylene diamine,3 have been used From Nectar to Glass: Quantification of Methyl Glyoxal in NZ Mānuka Honey and Mead Survey of commercial NZ meads The method was applied to a survey of all commercially available (explicitly) mānuka (n=8), and three non-manuka meads. Findings Only three of the commercial mānuka meads tested (MM1, MM4 & MM7) contained detectable levels of MGO. MM7 was noted to have been back-sweetened with mānuka honey - honey was added into the finished mead after fermentation. The other samples with MGO, MM1 and MM4, may also have been back-sweetened as they have high sugar content. Conclusions • Our developed method can efficiently quantify MGO in mānuka honeys and meads • MGO is NOT consistently present in mānuka meads –likely does not survive fermentation. Impact Our results show that producers should choose to reserve their more expensive mānuka honey for back-sweetening if an MGO- containing mead is desired. Next steps To further probe the interaction of yeast with MGO, we will apply the developed method to controlled lab-scale mānuka honey ferments – quantify MGO pre, mid, and post fermentation. Influence of: • MGO content of honey used? • Yeast strain? • Fermentation conditions? Comparison of derivatisation methods PFBHA o-Phenylene diamine Sample Preparation: ✓Simple sample prep ✓One hour incubation period ⨯Some phase splitting ⨯Precipitate at higher MGO concentrations ✓Simple sample prep ✓Overnight incubation period ✓Homogeneous samples High Concentration MGO: Low concentration MGO: o-Phenylene-diamine method selected due to better performance at lower MGO concentration (greater sensitivity), and fewer sample prep issues. Subsequently, the method was optimised at all steps: • Sample preparation • Incaution period/derivative stability • HPLC instrument method Then assessed for sensitivity: ✓LoQ = 0.58 mgL-1 in honey, 6.35 mgL-1 in mead And repeatability: ✓Experimental recovery 98-103 %, %RSD <4.5% Honey type MGO (mgL-1) Sugars (g L- 1) MM1 Mānuka 4.11 110.3 MM2 Mānuka Not detected 9.0 MM3 Mānuka Not detected 0.4 MM4 Mānuka 7.50 85.6 MM5 Mānuka Not detected 18.6 MM6 Mānuka Not detected 49.3 MM7 Mānuka 19.86 41.7 MM8 Mānuka Not detected 43.6 RM1 Rewarewa blossom Not detected 41.2 KM1 Kāmahi blossom Not detected 1.9 PM1 Pōhutukawa blossom Not detected 9.1 Claire Webstera, Rebecca Deedab, David Barkera, Lisa Pilkingtonac a) School of Chemical Sciences, The University of Auckland Waipapa Taumata Rau b) School of Biological Sciences, The University of Auckland Waipapa Taumata Rau c) Te Pūnaha Matatini References 1) J. Apic. Res. 1988, 27 (1), 62–67. https://doi.org/10.1080/00218839.1988.11100783 2) PLoS ONE 2016, 11 (11), e0167006. https://doi.org/10.1371/journal.pone.0167006. 3) Carbohydr. Res. 2008, 343 (4), 651–659. https://doi.org/10.1016/j.carres.2007.12.011. | poster |
Stellar magnetic fields are generated by dynamo mechanisms deep inside the stars. However, the type of dynamo cannot be the same for every star. It depends on the internal structure of the star which, in turn, depends on the stellar mass. In the Sun, for example, it is thought that field generation primarily occurs in a thin layer between the radiative core and the outer convective zone. This type of dynamo cannot operate in very low mass stars that are fully convective and therefore lack such an interface. The differences in the underlying dynamo manifest themselves in the properties of the magnetic fields at the stellar surface. Using Zeeman-Doppler imaging (ZDI), the strength and geometry of stellar magnetic fields can be mapped. In this poster, we use ~100 Zeeman Doppler maps to probe the underlying dynamos of ~50 stars. Introduction Saturated and unsaturated regimes The poloidal and toroidal components both follow the well known activity-rotation relation from X-ray studies. Both display the unsaturated and saturated regimes with the transition occurring at a Rossby number of ~0.1. The similarity between the two plots indicates that the poloidal and toroidal fields are generated from each other. The magnetic energy at the stellar surface can be broken down into various components that reflect the geometry of the magnetic field. The most commonly used components are the poloidal/toroidal components as well as the axisymmetric component. Field geometry When plotting the the toroidal magnetic energy against the poloidal magnetic energy, we find that the sample splits into two subsamples. Stars more massive than 0.5 M⊙ (circles) are able to generate toroidal field more efficiently and follow a different power law to stars less massive than 0.5 M⊙ (pentagons). This change in power laws is likely due to a change in internal structure as stars cross the fully convective boundary. See poster by Lisa Lehmann for further discussion. When plotting the percentage of magnetic energy in axisymmetric modes against the percentage of magnetic energy that is toroidal, we find that the most toroidal stars also have the most axisymmetric fields. This is a strong indication that toroidal fields are generated via differential rotation - an axisymmetric field generation mechanism. Conclusions In this poster, we have analysed ~100 ZDI maps of ~50 stars. This is the largest sample of stars gathered to date to study the behaviour of toroidal fields as a function of various parameters. We also find that the internal structure of a star affects the relative strengths of the poloidal and toroidal components. Fully convective stars appear to be remain dominantly poloidal whereas stars with radiative cores are able to generate dominantly toroidal fields. Lastly, we find that the most toroidal stars also have the most axisymmetric fields. On the other hand, the orientation of the magnetic axes of dominantly poloidal stars appear to be unconstrained relative to their rotation axis. We find that that the magnetic field strengths follow the activity-rotation relation. This provides another link between X-ray emission and the magnetic fields that generate them. Victor See1, M. Jardine1, A. A. Vidotto2, J.-F. Donati3, C. P. Folsom4 et al. The magnetic field geometry of cool stars 1University of St Andrews, 2Trinity College Dublin, 3University of Toulouse, 4University of Grenoble arXiv: 1508.01403 See et al. (2015) wcvs@st-andrews.ac.uk | poster |
Poster sessions 80 | P a g e estimating the efficacy of control measures is paramount to avoid potential outbreaks and have a better understanding of the epidemiology of the pathogen in such different environmental conditions (i.e. compared with geographical regions where Xylella was previously detected). Being pathogen-free, there are no epidemiological data regarding the UK, therefore we used all the available information to formulate qualitative and quantitative predictions, and theorise different scenarios. In particular, we model short-distance dispersal, stochastic long-distance dispersal, control zones (in agreement with the methodology employed in Apulia), and different levels of surveillance and detection efficacy. Modelling xylem temperature in olive and almond trees to estimate Xylella fastidiosa infection in woody hosts Navas-Cortés JA*, Román-Écija M, Landa BB, Testi L *Instituto de Ciencias Agrarias (ICA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid (ES) The present work was presented in the framework of the Joint Annual Meeting of the EU Horizon 2020 Projects POnTE ‘Pest Organisms Threatening Europe' (GA 635646) and XF-ACTORS ‘Xylella fastidiosa Active Containment Through a multidisciplinary-Oriented Research Strategy' (GA 727987). Abstract: Xylella fastidiosa (Xf) can infect a wide range of woody crops that are grown extensively worldwide. The temperature patterns inside the woody plant parts which are the habitat of Xf cells may nevertheless be different to those of the standardly recorded air temperature, due to the wood thermal inertia, wind speed or incident radiation energy and its shading by the canopy. To investigate the relationship between the temperatures that can be reached in different parts of the xylematic system and those of the surrounding air, an experiment was conducted in Córdoba, southern Spain, from 2017 to 2019. In a high-density plot, a set of four mature olive trees (two with maximum exposure to sunlight on the southern border and two in the middle of the plot) were instrumented with a multiplexed set of specially-made thermocouples placed in different parts of the active xylem tissues. Measurements were made uninterruptedly from winter 2017 to spring 2019 at 10-min. intervals: inside small branches (1 cm diameter), inside the trunk at 2 and 4 cm depths, and in the soil underneath the trees at 20 cm depth. This set was replicated on the southern (sunlit) and northern side of each tree; in situ standard measurement of air temperature at 1.5 m height was also recorded. The experiment was replicated in a nearby almond tree plot. Solar radiation, air temperature and wind speed were measured concurrently in a nearby meteorological station. Our results indicate that winter standard air temperature minimums closely match those of all the above-ground xylematic systems, while maximums may differ substantially (> 20 °C), especially in the deeper xylem rings. For these parts and the root xylem, a model of heat transfer which includes the shading effect may be necessary. These results would allow a better parametrisation of epidemiological models used to estimate the development of Xf infection in woody hosts. Acknowledgement This work has received funding from 727987 XF-ACTORS (EU-H2020), E-RTA2017-00004- C06-02 from AEI-INIA Spain and FEDER, and the Spanish Olive Oil Interprofessional. Session: Insect vectors Vector parameters relevant to model the management of Xylella fastidiosa pauca ST53 invasion Porcelli F*, Liccardo A, Fierro A *Dipartimento di Scienze del Suolo, della Pianta e degli Alimenti, University of Bari Aldo Moro (IT) Abstract: We present a model, based on both Life Table and Statistical Mechanics techniques, aimed at identifying a valid Integrated Pest Management strategy to mitigate | poster |
• Background: QCD di-jet events • Anomalous signatures: - Narrow and Broad RS gravitons ( ) - New scalar boson ( ) G →W W A →HZ →Z Z Z Quantum anomaly detection in the latent space of proton collision events at the LHC V.Belis1,2, Ema Puljak1,3, K.A.Woźniak1,4, G.Dissertori2, F.Reiter2, M.Grossi1, M.Pierini1, P.Barkoutsos5, I.Tavernelli5, S.Vallecorsa1 We propose a new strategy for anomaly detection at the LHC based on unsupervised quantum machine learning algorithms. To accommodate the constraints on the problem size dictated by the limitations of current quantum hardware we develop a classical convolutional autoencoder. The designed quantum anomaly detection models, namely an unsupervised kernel machine and two clustering algorithms, are trained to find new-physics events in the latent representation of LHC data produced by the autoencoder. The performance of the quantum algorithms is benchmarked against classical counterparts on different new-physics scenarios and its dependence on the dimensionality of the latent space and the size of the training dataset is studied. For kernel-based anomaly detection, we identify a regime where the quantum model significantly outperforms its classical counterpart. An instance of the kernel machine is implemented on a quantum computer to verify its suitability for available hardware. We demonstrate that the observed consistent performance advantage is related to the inherent quantum properties of the circuit used. Abstract LHC pp collision (MC simulation) Physics signatures Features (Δη, Δϕ, pT) 100 particles x ... ... ... ... ... ... ℓ Dimensionality reduction Models for Quantum anomaly detection • To address limitations of NISQ devices • Convolutional AE - acts per-particle level Quantum Kernel: k(xi, xj) = |⟨0|U†(xi)U(xj)|0⟩|2 Unsupervised quantum kernel machine Designed data encoding map to be hardware efficient, adequately expressive and have non-trivial interaction between input features U(x) G (θ, ϕ, λ) ∈SU(2) data encoding c o s ( θ 2 ) e−iλ s i n ( θ 2 ) eiϕ s i n ( θ 2 ) ei(ϕ+λ)s i n ( θ 2 ) Clustering algorithms Use amplitude encoding to map inputs to quantum states Cluster assignment using quantum circuits for distance calculation and optimization procedures QK-means / QK-medians QK-means quantum circuit 1. Distance calculation (Figure below/ H gate on MSQ - destructive interference probabilities) 2. Grover search algorithm / Hybrid quantum-classical optimization Results Convolutional AE Conclusions • We presented a systematic study of QML models for anomaly detection in proton collisions, comparing them as a function of anomalous physics signatures, latent dimensionality and training size • We observed the window of quantum advantage for unsupervised quantum kernel machine • Quantum clustering algorithms show advantage for smaller training size • Preprint: arXiv:2301.10780 Quantum harware results Kernel Machine Run AUC htr⇢2i Hardware L = 1 0.844 0.271(6) Ideal L = 1 0.999 1 Hardware L = 3 0.997 0.15(2) Ideal L = 3 1.0 1 Classical 0.998 - L = number of repetitions of U(x) Quantum advantage window • Consistent performance advantage ( > 1) in parameter space () • Inscrease of expressibility and entanglement of circuit leads to rise of performance up to maximum L=4 (left figure) • For L=3 algorithm performs better for higher number of qubits (inner plot in left figure) ΔQC 1 2 3 4 5 | poster |
INSTITUTE FOR INTERNATIONAL RESEARCH ON CRIMINAL POLICY FINANCIAL CRIME SCRIPT OF SYNTHETIC DRUG PRODUCTION Sophia De Seranno | Prof. dr. Charlotte Colman Sophia.Deseranno@Ugent.be | +32 (0)9 264 68 38 Department Criminology, Criminal Law and Social Law Universiteitstraat 4, 9000 Ghent De Seranno, S., & Colman, C. (2024). Geldstromen gerelateerd aan synthetische drugsproductie in België. In. T., Snaphaan, & P., Klerks (eds.). Crime Scripting; Theorie en Praktijk, Boom. Sources: Snaphaan et al. (2023); Snaphaan & van Ruitenburg (2024); Van Santvoord & van Ruitenburg (2022) The production, wholesale, middle level and retail of synthetic drugs (syndrug): all present in Belgium Large-scale production of (meth)amphetamine & MDMA = profit-driven crime by organised crime groups Money flows: costs, revenues, financing related to syndrug production in Belgium? judicial case file study + interviews with inmates Financial Crime Scripting (FCS) + Social Network Analysis (SNA) S1 S2 S4 S6 S1 S2 S4 S6 Financial actors: network position and connections of financers/investors/ money launderers? FCS of large-scale syndrug production Position and connections of financial actors - 119 financial actors involved in 4 scenes of syndrug production (S1, S2, S4 and S6) - Frequently interconnected →clusters - FCS is a useful tool for both practice ánd scientific research: provides insights into money flows of complex and profit-driven crime by organised crime groups - A combination of quantitative and qualitative data is preferable - FCS and SNA can strengthen each other ? ? | poster |
19°0'0"E 18°E 17°E 16°E 15°E 14°E 13°E 45°N 44°N 43°N 42°N 41°N 40°N 0 100 200 50 km A B -200 -1200 -500 (m) A B Slope section ADW NAdDW LIW -0 A NAdDW production area NAdDW LIW ADW Ionian Sea Tyrrhenian Sea Italy Adriatic Sea Hotspot Ecosystem Research and Man's Impact On European Seas Annual meeting 2011 Malaga, 11-15 April 2011 CONSIGLIO NAZIONALE DELLE RICERCHE Istituto di Scienze Marine Submarine slides Canyons Gondola deformation belt Seamount Mooring stations 0 10 20 30 40 5 Km - 35 m -1205 water depth A 0 10 20 30 40 5 Km Giant grooves Barchan crest Furrows Mud waves ridge Scour Mud waves area Furrows area Giant sediment drift area Moat area Comet mark area Complex area N 3 km 50 m 1200 m AR89 D AR89 0 45 90 135 180 225 270 315 0 4 8 12 (cm/sec) 0 45 90 135 180 225 270 315 0 5 10 15 20 25 (cm/sec) 2 4 3 5 6 1 2 3 4 5 6 1 12 Km N 6 km N SE120 SE151 SE151 600 575 625 550 msec 1200 m -850 -900 -950 -1000 m 1 km The reshaping of the South West Adriatic Margin by pervasive dense shelf water cascading Foglini F., Trincardi F., Campiani E. & Langone L. Istituto di Scienze Marine ISMAR – CNR, Bologna, Italy Simplified intermediate- and deep-water circulation in the Adriatic Sea: NAdDW=North Adriatic Dense Water; LIW=Levantine Intermediate Water; ADW=Adriatic Dense Water. Cascading NAdDW impact the seafloor of the SW Adriatic margin, eroding and depositing large amounts of fine-grained sediment below a markedly erosional upper slope. By cascading across the slope over a prolonged interval (several weeks each year), the dense NAdDW impinges the seafloor and interacts with the margin morphology, generating: patchy fields of large-scale mud waves; a variety of erosional bed forms, such as moats, furrows and comet marks; an area of widespread sea floor erosion. The Southwest Adriatic Margin includes a steep and morphologically complex continental slope stretching about 400 km from the Pelagosa sill to the Otranto strait. The area has been investigated through multibeam surveys accompanied by high-resolution seismic stratigraphic surveys investigating glacial and post-glacial deposits. The margin is dissected by submarine slides, with head scars up to 10 km along the shelf edge and run-out distances of tens of km, an active fault system (the Gondola deformation belt), Bari Canyon and a set of shallowly incised and relatively straight canyons located further south. After the end of the last glacial sea level low stand the North Adriatic shallow shelf became progressively drowned as a consequence of the eustatic rise. Through its progressive drowning, this region became a shallow shelf and one of the Mediterranean key sites for the formation of dense shelf waters through wind-forced winter cooling. The dense waters formed through this process move to the south, along the western side of the Adriatic, and reach the South Adriatic slope across which they cascade hugging the sea floor and generating a myriad of depositional and erosional effects such as: giant sediment drifts down to 1200m water depth, muddy and sandy sediment waves, comet marks against pre-existing slide blocks, furrow fields, large scours at the shelf edge and large erosional moats against major morphological barriers. CONCLUSION -The cascadings of dense shelf watersconcur to a thorough “restyling” of the margin morphology interacting with the pre-existing and markedly differentiated morphologies and sediment distribution. -Mapping the active bedforms and the areas of dominant seafloor erosion allows quantification of the extent to which bottom-hugging currents are effective in reshaping the margin morphology. -The seasonal impact of cascadings water has also a major effect on benthic fauna distribution. Furrow fields at the base of the southern slope with an area of 71.69km2 in water depth between 753 and 960m. The field emanates from the mouth of a slope gulley oriented roughly N-S and appear to expand and diverge eastward. The typical depth of the furrow is 0.5m and | poster |
“source beam filling factor” τ = 1000 s background temp.: 300 K Towards a Broadband Q-Band VLTI Heterodyne Instrument E. A. Michael 1, L. Labadie 2, N. Honingh 2, K. Jacobs 2, U.U. Graf 2, S. Schlemmer 2, J. Stutzki 2 1 Department of Electrical Engineering, University of Chile, Av. Tupper 2007, Santiago, Chile 2 1. Physikalisches Institut, Universität zu Köln, Zülpicher Str. 77, 50937 Köln, Germany Abstract- Expanding VLTI long-baseline interferometry to some atmospheric windows in the Q-band (e.g. 20.5 or 24.5 µm) would offer strong complementarity between the Paranal instrument suite and ALMA to observe bright, massive, embedded objects but also giant stars. In this limited spectral range, the heterodyne approach is appropriate considering the high thermal background, along with recent experimental findings on a quantum-limit heterodyne detection scheme allowing to envision competitive spectral resolution. A new class of heterodyne mixers to be developed in the next years may extend the bandwidth up to hundred GHz. IF-processors could sub-divide this into por- tions manageable by next generation digital correlators. QCL telescope-LOs could be phase-locked to a central reference laser at 1550 nm. Fringe tracking information from ex- isting shorter wavelength instruments could generate a suitable phase-modulation of the LOs to compensate piston phase jitter making very long integration times possible. MOTIVATION AND GENERAL CONCEPT Proof of Concept at 1.55µm with small telescopes on very bright stars 1.4 – 1.8 mm is an atmospheric window with >95% transmission (H-band) High-precision phase control beneficial for largest baselines + nulling interferometry Mobility: connect any group of existing less-used medium size optical telescopes (e.g. at La Silla, Paranal, Las Campanas, or Tololo, Chile) Baselines of many km should be possible: try the 14” Goto-Dobsonians with the ALMA buried fibers to run a demonstration experiment ESO VLTI workshop München Garching, 17 June - 20 June, 2019 4. Visions Migrate the near-IR prototype to mid-IR by developing the graphene mixers and tunable mid-IR LOs Use triple-correlation signals (containing phase closure) to enable long integration times Increase the IF-bandwidth, use faster digital correlators proof frequency averaging mode and dispersed heterodyne receiver concept (optionally first at 1550 nm) Use our interferometer prototype as a test bench for fast mid–infrared receivers identify and adapt tunable sources or frequency combs in the mid-infrared for LO-purposes 3. Heterodyne versus direct detection thanks to CONICYT-ALMA funds Nº 31090018 and 31140025, QUIMAL Nº150010, CATA-Basal PFB-06, ESO Mixed-Committee 2016 + 2018 ©NASA ©ALMA ©ESO Science goals for using very large telescopes in the N– and Q-band Active Galactic Nuclei Planet Formation Stellar Formation and Evolution Two-telescope version 2. Proposal: Develop BCRs at mid-infrared wavelengths Various options ffor universal and fast IR-materials/architectures In synergy with SOFIA developments, try microfabrication and test, first as single mixers: 1. Graphene-based plasmonic coupling photoconductive mixers reaching >50 GHz IF: 2. Alternative 1: Traveling-wave metal-insulator-insulator-metal tunneling junctions (TW-MIIM): 1. New concept of Balanced Correlation Receivers (BCR) De-correlation of quantum noise of local oscillator at power splitters enables to reach quantum-noise limit and even overcome it: experimental evidence at 1550 nm Investigated with digital correlation using a ROACH-board (Xilinx FPGA-board with two 3 GSPS) 3. Alternative 2: Travelling-wave (new!) HgCdTe-photodiodes (“TW-MCT”) Then try to combine pairs of single mixers to balanced mixers Conducting a BCR experiment at 450 GHz to check quantum effect observed at 1550 nm Developed tip-tilt correction with magnetic fiber actuator Plotted are pre-detection SNRs: radiation- noise limited worsens by detection efficiency + post- | poster |
1ª SEMANA CIENTÍFICA MULTIDISCIPLINAR "ESPERANÇARTE" Não há distância para quem canta! 1 2 4 3 INTRODUÇÃO Esta pesquisa tem como objetivo promover a prática de artes integradas com base nas Artes Visuais e na Música associadas ao conhecimento das Tecnologias aplicadas à Educação Infantil. Como campo para o exercício dessas práticas, utilizou-se o espaço escolar, equipe pedagógica e parceiros comunitários do Centro Municipal de Educação Infantil Odila Simões, localizado no bairro Quadro na capital Vitória-ES. Em outras palavras, vale considerar a importância dessas práticas, tendo em vista que, em geral, desde os primeiros anos de formação do sujeito, as artes e as tecnologias desempenham um papel fundamental no desenvolvimento cognitivo dos alunos. Nesse sentido, essas práticas contribuem significativamente para uma aprendizagem que estimula a sensibilidade e o exercício da cidadania ativa na sociedade atual. MATERIAIS E MÉTODOS A proposta metodológica assume uma abordagem qualitativa, uma vez que os materiais utilizados foram estabelecidos de acordo com a formação acadêmica de cada profissional envolvido na organização do evento. Para a realização das atividades foram empregados instrumentos musicais, softwares, vetores, materiais para pintura e arte, que culminaram em dinâmicas musicais e coreográficas com alunos, professores e demais parceiros comunitários da referida escola. PREFEITURA MUNICIPAL DE VITÓRIA SECRETARIA MUNICIPAL DE EDUCAÇÃO CENTRO MUNICIPAL DE EDUCAÇÇAO INFANTIL CMEI ODILA SIMÕES RESULTADOS Essas práticas no ambiente escolar contribuem para a promoção da criatividade e a ampliação da visão de mundo dos alunos da instituição. Além disso, a realização dessas atividades possibilitou a publicação de dois volumes do livro MUSICOLORIR. Portanto, as reuniões de planejamento deste evento proporcionaram engajamento social entre a comunidade e profissionais de diferentes áreas do conhecimento e, com isso, os alunos da escola puderam se familiarizar com conhecimentos sobre símbolos e instrumentos musicais, artes visuais e tecnologias. CONCLUSÃO As artes são fenômenos da natureza que estão presentes em diversas manifestações sociais, inclusive nos ambientes escolares. Nesse sentido, ao iniciarmos os primeiros processos de desenvolvimento humano — a infância — as artes terão um papel fundamental na promoção da sensibilidade coletiva. Ademais, o uso das tecnologias na educação pode contribuir para a valorização das habilidades artísticas, o desenvolvimento escolar e o exercício da cidadania de todos os envolvidos. Portanto, os desdobramentos dessas atividades didático- pedagógicas contribuíram para proporcionar acessibilidade a essas práticas, atingindo um público amplo de diferentes atores da educação infantil. REFERÊNCIAS BRASIL. Ministério da Educação. Base Nacional Comum Curricular. Brasília, 2018. Esp. Luciene Rodrigues Bernardino luarter1@gmail.com Me. Thiago Pessanha Correa thipesscorr@gmail.com Esp. Elenisio Rodrigues Barbosa Junior elenisiopiano@gmail.com | poster |
[1] R. Voytovych, V. Bougiouri, N. R. Calderon, J. Narciso, N. Eustathopoulos, Reactive infiltration of porous graphite by NiSi alloys, Acta Mater. 56 (2008) 2237–2246. [2] B. Drevet, N. Eustathopoulos, Wetting of ceramics by molten silicon and silicon alloys: a review, Journal of Materials Science 47 (2012) 8247–8260. [3] M. Naikadea, B. Fankhänel, L. Weber, A. Ortona, M. Stelter, T. Graule, Studying the wettability of Si and eutectic Si-Zr alloy on carbon and silicon carbide by sessile drop experiments, J- Eur. Ceram. Soc., 39 (2019) 735-742. Conclusions Wetting behavior and reactivity of liquid Si-10Zr alloy in contact with Glassy Carbon and SiC Donatella Giuranno1, Adelajda Polkowska2, Wojciech Polkowski2, Grzegorz Bruzda2, Enrica Ricci1, Rada Novakovic1 1Institute of Condensed Matter Chemistry and Technologies for Energy, National Research Council, CNR-ICMATE, Via De Marini 6, 16149, Genova, Italy 2Foundry Research Institute, ul. Zakopianska 73, Krakow, Poland donatella.giuranno@ge.icmate.cnr.it Acknowledgements The NCN-National Science Center, Poland is greatly acknowledged for the financial support through the POLONEZ project number UMO-2016/23/P/ST8/01916. This project was carried out under POLONEZ-3 program which has received funding from European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement. No 665778. Materials Science Materials Design MexSiy SiC Impact Currently, the main challenges facing the development of advanced refractory MMCs (SiC- ZrSi2) and CMCs (C/C-ZrC-SiC) are related to the costly fabrication of tailored and performant interfaces microstructures for highly demanding applications, to optimize the fabrication process and to identify ad-hoc the metal matrix for each application. Goal Aiming to ‘‘mimic’’ the conventional operating conditions imposed in fabricating MMCs via liquid assisted processes such as reactive infiltration, the contact heating sessile drop method (CHSD) was applied for better understanding the interaction phenomena occurring between the liquid Si-10at%Zr alloy in contact with Glassy Carbon (GC) and SiC substrates. Specifically, the contact angles behaviors as a function of time were obtained over the temperature range of T = 1354-1500°C under an Ar atmosphere. Why? Fundamental investigations performed under well-defined operating conditions on the occurring interfacial phenomena between liquid Si-Zr alloys in contact with C and SiC substrates, are key steps for optimizing liquid assisted processes (reactive infiltration). Targeted wettability and reactivity studies can easily provide useful indications for solving many technological problems affecting the reactive infiltration mechanisms, such as pore closure/narrowing phenomena. Introduction Computational models are enabling the design and manufacture of costless and high quality advanced complex metal-based materials such as SiC-based composites, since longer gaining interest for the use in aerospace, automotive, defense, nuclear reactors and various other engineering applications. In particular, the production of tailored SiC-based composites via reactive infiltration of Si-based alloys into C-and SiC-based preforms, mainly by assisting computational simulations, is currently one of the main goals of materials design. T ≤ 1700°C, 1 Ptot 10-6 mbar C-heater acting as O2-getterSi-Zr Phasediagram ZrSi2 ZrSi2 Si-8.6at%Zr 20 mm 20 mm Si-10at%Zr as-cast Arc melting 1 mm W ≈ 50 - 60 mg Glassy Carbon (GC) Alfa Aesar, Ra ≈ 20 nm HP SiC (SiC) Goodfellow, Ra ≈ 1mm 3D Profilometer/confocal optical microscope Substrates Sample C-tube Coil Water-cooling CCD Camera Pyrometer Heating rate ≤ 15/s, Cooling rate = 20/s Thermocouples/Pyrometer Real-time residual gas analysis Real-time acquisition data (ASTRAview) CCD camera Feed GAS HV Pump MV Pump Water cooled quartz tube CoilExperimentalset-up Materials & Method SEM/EDX analyses (top drop) of Si-10Zr/GC couples after wetting tests at T = 1354- | poster |
Scan the QR code to access an electronic copy of the poster (‘smart poster’) that includes links to the audio poster summaries from these co-authors DIA 2020 Global Annual Meeting; #89465 What pharmaceutical company leaders say and what patient leaders think: Quantitative and qualitative analyses Introduction • Pharmaceutical company leaders (eg, board chairs) can help drive a patient-focused cultural shift in their organizations. • Cultural change could be signalled through the words used by board chairs in their widely circulated, highly visible, and influential annual reports. • This ‘top down’ signalling could reinforce a company-wide commitment to partnering with patients, as well as reflecting ‘bottom up’ patient-centric initiatives being pursued across the company. Objectives To investigate: A. The frequency and context of the use of the word ‘patient’ by board chairs of the top 10 global pharmaceutical companies, and whether this usage changed from 2008–2018 B. How usage related to patient groups’ views of these companies. References 1. INVOLVE UK. What is public involvement in research? Available from: https://www.invo.org.uk/find-out-more/what-is-public-involvement-in-research-2/ 2. Corporate reputation of pharma in 2018 - the patient perspective (publicly accessible information only). Available from: https://www.lundbeck.com/upload/global/files/pdf/features/PATIENTVIEW%20PRESS%20RELEASE%2 0APRIL%202018.pdf Acknowledgments and disclosures We thank Envision Pharma Group for funding poster development. KW, LA, AB are Envision employees. CS was paid by Envision to prepare the audio script; no payment was received for authorship. All authors support patient involvement in medicines development. Results A. Frequency and context of the use of the word ‘patient’ by board chairs in annual reports Karen L. Woolley,aCarole Scrafton,b Amanda Boughey,cLauri Arnsteinc aEnvision Pharma Group, Australia, and University of Queensland, Australia; University of the Sunshine Coast, Australia; bFibroFlutters, UK; cEnvision Pharma Group, UK Methods 1 Obtain e-copies of the 2008 and 2018 annual reports of the top 10 global pharmaceutical companies (based on 2018 sales). 2 Use summative content analysis to assess the frequency and context of use (based on definitions adapted from INVOLVE UK1). 3 Compare results to PatientView rankings of these companies based on input from 1500 patient groups in 78 countries.2 0.44% 0.69% 2008 2018 • Use of the word ‘patient’ was low (<1% of words used) • Use remained low, but increased in 2018 Mean word count of annual report = 1627 Mean use of ‘patient’ = 7.5 (0–21) Mean word count of annual report = 1390 Mean use of ‘patient’ = 10.1 (0–45) B. Comparison with PatientView rankings 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 Pfizer Roche Novartis J&J Merck & Co (MSD) Sanofi AbbVie GSK Amgen Gilead % of annual report word count 2008 2018 • Use of ‘patient’ as an active partner was low (<5% of use)* • Use as an active partner remained low, but increased in 2018 1.86% 3.87% 2008 2018 We listen intently to healthcare communities, starting with patients, who visit our facilities to speak with, teach, and inspire us. Robert A. Bradway, Board Chair, Amgen, 2018 Example of active partner use““ * For reporting integrity and completeness, board chairs would need to review robust metrics on ‘patients as active partners’ initiatives across their companies (eg, via a Patient Partnership Dashboard with metrics for active partnerships by region, by function, by therapeutic area). Words matter. Pharmaceutical company leaders could help drive a patient-focused culture by enhancing the frequency and context of their use of the word ‘patient’ in their annual reports ^can Limitations • Pharmaceutical companies could have had active partnership projects with patients that were not reflected in board chair reports. • Our sample only included the top 10 global pharmaceutical companies. • We could only use the publicly accessible ranking inf | poster |
EGU24-20264 Erlendsson et al. (2024) REFERENCES Blischke, A., Brandsdóttir, B., Stoker, M. S., Gaina, C., Erlendsson, Ö., Tegner, C., Halldórsson, S. A., Helgadóttir H. M., Gautason, B., Planke, S. & Hopper, J. R. (2022). Seismic volcano-stratigraphic characteristics of the Jan Mayen microcontinent and Iceland Plateau rift sys-tem. Geochemistry, Geophysics, Geosystems, 23, e2021GC009948. https://doi.org/10.1029/2021GC009948 Blischke, A., Brandsdóttir, B., Karson, J. A., and Erlendsson, Ö. (2024). Fracture zones and rift systems of eastern Iceland: Tectonic and geodynamic links to extinct rifts on the Iceland-Faroe Ridge and Iceland Plateau. EGU General Assembly 2024, Vienna, Austria, 14–19 Apr 2024, EGU24-12369. https://doi.org/10.5194/egusphere-egu24-12369 Erlendsson, Ö., Blischke, A., Hjartarson, Á., Óðinsson, D.Þ. & Vésteinsson, Á.Þ. (2023). The Geological mapping of Iceland’s Insular Shelf and Adjacent Deep Ocean. EGU General Assembly 2023, EGU23-15536. https://doi.org/10.5194/egusphere-egu23-15536. Gaina, C., Nasuti, A., Kimbell, G. S. & Blischke, A. (2017). Break-up and seafloor spreading domains in the NE Atlantic. Geological Society, London, Special Publications, 447(1):393. https://doi.org/10.1144/SP447.12 Hjartarson, Á. & Erlendsson, Ö. (2018). The Geology of Iceland´s Insular Shelf and Adjacent Deep Ocean: The Contribution of Iceland GeoSurvey to EMODnet. Íslenskar orkurannsóknir, ÍSOR 2018/027, p. 125. Hopper, J. R., Funck, T., Stoker, M. S., Árting, U., Peron-Pinvidic, G., Doornenbal, H. & Gaina, C. (2014). Tectonostratigraphic Atlas of the north-east Atlantic region. The geological survey of Denmark and Greenland (GEUS) (1st ed.). ISBN 9781786202789 Höskuldsson, Á., Hey, R., Vésteinsson, Á.Þ. & Kjartansson, E. (2009). Þróun eldvirkni við Vestmannaeyjar síðustu 20 þúsund ár. Í Sjór og sjávarlífverur, ráðstefna haldin 20.–21. febrúar 2009. Reykjavík, Hafrannsóknastofnun, Hafrannsóknir, 143, p. 19. Höskuldsson, Á, Kjartansson, E., Vésteinsson, Á.Þ., Steinþórsson, S. & Sigurðsson, O. (2013). Eldstöðvar í sjó. In: Sólnes, J., Sigmundsson,F. & Bessason, B. (ed). Náttúruvá á Íslandi — Eldgos og jarðskjálftar. Reykjavík, Viðlagatrygging Íslands/ Háskólaútgáfan. Magnúsdóttir, S., Brandsdóttir, B., Driscoll, N. & Detrick, R. (2015). Postglacial tectonic activity within the Skjálfandadjúp Basin, Tjörnes Fracture Zone, offshore Northern Iceland, based on high resolution seismic stratigraphy. Marine Geology, 367, 159-170. Nasuti, A. & Olesen, O. (2014). Magnetic data. In J. R. Hopper, T. Funck, M. S. Stoker, U. Árting, G. Peron-Pinvidic, H. Doornenbal & C. Gaina (Eds.). Tectonostratigraphic Atlas of the north-east Atlantic region. The geological survey of Denmark and Greenland (GEUS) (1st ed.). ISBN 9781786202789 Þórarinsson, S. (1965). Neðansjávargos við Ísland. Náttúrufræðingurinn, 35, 49–74. | poster |
Methods Conclusions Synthesis of porous MnO2 nanorods and electrochemical performance Yogesh Kumar1, A. Gupta1, S Chopra1, A Kumar2, Y Kumar3 1School of basic and applied science, G.D. Goenka University, Gurugram, Haryana, India, 122103. 2Institute Instrumentation Centre, I. I. T. Roorkee, Roorkee Uttarakhand, India, 247667. 3Department of Physics, ARSD College, University of Delhi, New Delhi-110021. Bibliography 1. Z. Yang et al., “Electrochemical Energy Storage for Green Grid,” Chem. Rev., vol. 111, no. 5, pp. 3577–3613, May 2011, doi: 10.1021/cr100290v 2. Trasatti S, Buzzanca G. Ruthenium dioxide: a new interesting electrode material. Solid states structure and electrochemical behaviour. J Electroanal Chem. 1971;29(2):A1–A5. 3. Cao JY, Li XH, Wang YM, et al. Materials and fabrication of electrode scaffolds for deposition of MnO2 and their true performance in supercapacitors. J Power Sources. 2015;293:657–674 4. Augustyn V, Simon P, Dunn B. Pseudocapacitive oxide materials for high-rate electrochemical energy storage. Energy Environ Sci. 2014;7(5):1597–1614 5. H. Y. Lee and J. B. Goodenough, “Supercapacitor Behavior with KCl Electrolyte,” Journal of Solid State Chemistry, vol. 144, no. 1, pp. 220–223, Apr. 1999 A facile one-step hydrothermal method to prepare porous MnO2 nanorods at 110 °C for their application as electrode materials for high-quality supercapacitors. The materials is characterized by X-ray diffraction, Transmission electron microscope. The electrochemical utilization of manganese dioxide (MnO2) is investigated by cyclic voltammetry, galvanostatic charge discharge in aqueous 1M KOH electrolyte. Since very similar specific capacitance values of about 236 F/g at 5 mV/s is found for samples, MnO2 electrochemical utilization is more related to the pore size distribution as well as nanoroad size. The supercapacitor exhibits specific energy 5.18 Wh/kg and specific power of 242 W/kg. Introduction Results Coal 42% Natural Gas 21% Oil 5% Nuclear 14% Hydroener gy 15% Renewable 3% Coal Natural Gas Oil Nuclear Hydroenergy Renewable Global energy demand continuously increasing, fossil fuels are the major sources of electrical energy but are in limited amount so we need renewable energy sources. As renewable energy sources are not available round the clock, so energy storage is required. Figure 1. Source of electrical energy [1]. Supercapacitor Electric Double-layer Capacitors (Electrostatically) Activated Carbon Carbon Aerogels Carbon Nanotubes Pseudocapacitor (Electrochemically) Conducting Polymers Metal Oxide Hybrid Capacitors (Electrostatically and Electrochemically) Composite Asymmetric Battery-type Literature Review: MnO2 based Supercapacitors: qThe chemically fabricated metal oxides such as RuO2, MnO, TiO2, NiO, CoO, NiO, CuO, and composite materials are potential candidate for supercapacitor applications qRuO2 and MnO2 are the prominent electrode material due to higher energy density material with higher theoretical capacitance about 1450 and 1270 F g−1 respectively [2,3] qHowever, RuO2 suffers from being extremely expensive (5000/- @1g), not earth abundant, and somewhat toxic [4] qManganese exists in a variety of stable oxides (MnO, Mn3O4, Mn2O3 and MnO2) qAnother benefit of MnO2 is cheap material cost, plentiful in the earth’s crust, and environmentally friendly qThe charge storage capacity depends on crystal structure, surface area, porosity and intercalated cations. Grinding Magnetic stirring Hydrothermal reactor Oven Centrifuge Muffle furnace • For nanostructured MnO2, 2 gm of KMnO4 and 0.8 gm of Mn(CH3COO)2·4H2O) was added in the premixed solution of ‘5ml TEA ethoxylate and 50 ml double distilled water’ under magnetic stirring • The hydrothermal reaction temperature were kept at 110 °C for 12 hr to obtained MnO2 powder • Further, the as-synthesized precursor is calcined at 300 °C in the air for 6 hrs at ramping rate for 1 °C per min to get the final products Structural Parameter (110 OC) Number of space group | poster |
Simple cells modeling through a sparse overcomplete Gabor wavelet representation based on local inhibition and facilitation Rafael Redondo1, Sylvain Fischer1, Laurent Perrinet2 and Gabriel Crist´obal1 1 Instituto de Optica (CSIC), Serrano 121, 28006 Madrid, Spain 2INCM/CNRS, 31 ch. J. Aiguier, 13402 Marseille Cedex 20, France {rafa, sylvain, gabriel }@optica.csic.es Laurent.Perrinet@incm.cnrs-mrs.fr 1 Receptive fields: log-Gabor filters space (real part) space (imag. part) Fourier domain Figure 1: log-Gabor filters Model for the Simple cells receptive fields: • log-Gabor filters [1, 2]. • frequency bandwidth = 1.85 octave. • half-orientation bandwidth = 25 degrees for a 6 orien- tations scheme (18.5 degrees for 8 orientations). log-Gabor wavelets implementation : • 5 scales separated by 1 octave, 6 or 8 orientations. • Same filters both for the wavelet transform (W) and for the inverse (WT). • exact reconstruction (∀x ∈RN, WTWx = x). • overcompleteness: factor of 28 using 6 orientations (factor of 37 using 8 orientations). space (real part) space (imag. part) Fourier (contours) Figure 2: log-Gabor wavelets on 5 scales, 8 orient. 2 Non-linear lateral interactions: sparse coding and edge extraction 2.1 Need of sparse coding • The linear transform induces redundancy. • There is non-uniqueness of the representation. • Sparse representations are available. ⇒Necessity of a sparse coding algorithm [3, 4]. ⇒Sparse coding algorithms represent adaptively the sig- nals through a selection of coding functions taken from an overcomplete set. image linear log-Gabor sparse representation 2.2 Local competitions and cooperations Non-linear interactions between neighboring cells Selection of coefficients inspired from the architecture of V1 cortical columns: • Inhibition of non-local maxima (or competition [5]). • Enhancement of colinear and coaligned coefficients (or cooperation [6]). ⇒Efficient for edge and contour extraction [5, 6, 7] (and Fig. 4) and for sparse coding [8, 9]. response to a ridge response to an edge Figure 4: complex-valued log-Gabor response to ridges and edges 2.3 Algorithm for edge selection and back- projection of the residual input image linear Gabor transform (3 adjacent channels) remaining coefficients after the competition Cooperation: chain length calculation and amplitude propagation • Thresholds of selection on the chain length and on the maximum of amplitude along the chain. • Non-selected coefficients r are projected on the trans- form space by the WWTr operation. • Exact reconstruction (WTWWTr = WTr). • Repeating several times the projection (e.g. 30 times) enhances selected coefficients (typically by a factor of 7), while close non-selected coefficients vanish. Figure 6: Amplitude growing of a selected coefficient through iterative projection of the non-selected ones. Vanishing of the neighboring non-selected coefficients. 2.4 Contour representation by chain coding Figure 7: Chain coding scheme. Coefficients are quantized in module and phase (8 phases). Specially adapted to Gabor wavelets features, our chain coding [10] represents every chain by its end-points (head and tail) and the elementary movements necessary to walk through the chain from head to tail. As a result, redun- dancy of the transform domain is further diminished. • Head position are referred to the previous coded head. • Movement scheme depends on channel orientation. • Quantized coefficient (module and phase) is predicted according to the previous coded link. Figure 8: Schemes of movement coding. Absence of movement means end-of-chain. Huffman codes compress head positions and movements and arithmetic coding does to coefficient amplitude. Residual low-pass channel is coded by a predictive codec adapted from FELICS [11]. 3 Evaluation We apply the model to tasks the Human Visual System (HVS) is supposed to deal with: edge and contour extrac- tion, noise segregation, sparse representation. 3.1 Edge extraction Using complex-valued Gabor filters both edges and lines | poster |
A community platform for accelerating observationally- constrained regional ocean modeling Dan Amrhein, Gustavo Marques, Helen Kershaw, Alper Altuntas, Keith Lindsay, Mike Levy, Fred Castruccio, Manish Venumuddula, Suman Shekhar, Anh Pham A major area of opportunity: cloud capabilities for ocean data + modeling Roo Nicholson, Susan Wijffels, Enrico Milanese Progress: Northwest Atlantic regional modeling in the Community Earth System Model Existing capabilities New capabilities DART data assimilation: learning from ocean data MOM6 + CESM: ocean + climate model • Rapid prototyping for regional domains • Advance nested model capabilities • Widely used model for climate research • Large database of global climate simulations Post-processing: big data tools • CESM interface • Observational database • Efficient algorithms • Observing system design • Python wrapper for C / Fortran code • Python diagnostics • Rapid prototyping for regional DA • Dask/Pandas/Xarray • Interactive user interface (Jupyter) • DART observation space diagnostics • Regional tools • Swappable backend • Online access point Objective: advancing + integrating cyberinfrastructure to unlock novel capabilities in ocean physics, the carbon cycle, and climate change Motivating use case: an unprecedented observing network to track carbon between the atmosphere and the ocean We are porting GFDL’s 1/12 degree MOM6 ocean model configuration into CESM. This configuration provides a template workflow for automation, a testbed for data assimilation and biogeochemical capabilities, and ocean science capabilities for WHOI partners. IPCC AR6 Natalie Renier, WHOI Ocean observations are scattered across databases and formats requiring ad-hoc technical solutions for each project. We need an open database designed for fast data access. Hosting cloud-based data and modeling capabilities would dramatically streamline workflows for regional oceanography and carbon cycle science. Progress: CESM-DART integration + pyDART We are modernizing DA output analysis and testing in-memory data transfer between CESM and DART using ESMF. | poster |
25-27 June 2008 Madrid, Spain Improving performance of a research project by continuous learning – a systematic approach Anandasivakumar Ekambaram 1, Andreas Økland 2 1SINTEF, 7031 Trondheim, Norway, siva@sintef.no 2SINTEF, 7031 Trondheim; Norway, Andreas.Okland@sintef.no What is the research project? The REZBUILD project (REfurbishment decision making platform through advanced technologies for near Zero energy BUILDing renovation) grows with the main aim of defining a collaborative refurbishment ecosystem focused on the existing residential building stock. • Awarded by the European Commission with a H2020 Programme Grant of € 6,996,128.25 • Total budget: € 9,038,208.75 • Duration: 4 years (Started in October 2017) REZBUILD will base its refurbishment ecosystem on the integration of cost-effective technologies, business models and life-cycles interaction. The project will focus on the retrofit of diverse residential typologies, interconnecting every building renovation stage as well as all stakeholders. https://rezbuildproject.eu/ An underlying aspect of learning in a project A project is, per definition, unique, and it provides several new experiences. Does a new experience itself guarantee learning?... Therefore, there should be adequate mechanisms for facilitating reflection on experiences in order to ensure learning and performance improvement in a project. Reflection When reflection is considered in connection with a professional action that an organizational member participates, then it can be viewed as reflection-on-action and reflection-in-action (Schön, 1998). • Reflection-on-action is a process in which the individual reflects on his or her past experience or on a future act deliberately or unintentionally. • Reflection-in-action is a process in which the individual reflects on what he or she is experiencing while he or she is engaging in the activity. These two categories of reflection play a notable role to in the learning process. What do we primarily do for capturing learning in the project? • REZBUILD has regular meetings with all of its partners – twice a year (in addition to more frequent online meetings). These meetings are arenas for collective reflection, sharing knowledge and experience, identifying challenges and opportunities. • We use a questionnaire to capture lessons learned in a six month period between project-partner-meetings. The questionnaire too provides possibilities for reflection and hence contributes to learning. It deals with, for instance, the following issues: o The degree of understanding that is obtained regarding own and other work-packages, as well as the project as whole o Skills that contributed to the project and the challenges of the project during the period o Improvement possibilities o Most interesting result for the project partner and the corresponding organization, obtained during the period o Important lessons learned for the project partner and for the project during the period – along with an explanation of why it is important o Changes in the organization and its role in the project due to the gained insight o Perception of the likelihood of achieving the objectives of the work-package as well the project Information obtained from the project partners will be analyzed and shared regularly, so that performance of the project will be improved. An effect of continuous learning in a project 19th European Conference on Knowledge Management | Italy, 2018 We do not learn from experience... We learn from reflecting on experience – John Dewey Continuous learning within a project Intra-project learning Improving productivity and performance of the project Inter-project learning Creating more value for other projects by knowledge transfer Learning organizations Reference: • Schön, Donald A. (1998). The Reflective Practitioner, How Professionals Think in Action: Ashgate Acknowledgement: This project has received funding from the European Union’s Horizon 2020 research and innovation | poster |
Hashed boxes : no tidal forcing Empty boxes: tidal forcing Blue: ORCA025, green: ORCA12, red: ORCA36 3 bands: o the large scales : from 1000 to 250 km ORCA12 and ORCA36 are close and ORCA025 is weaker in most of the boxes. o the mesoscales: from 250 km to the local first baroclinic Rossby radius of deformation The 3 configurations well differ: ORCA025 is not able to represent all the mesoscale ORCA12 can not represent the finest mesoscale processes. ORCA36 is able to represent all the mesoscale processes. o the sub-mesoscales: from the first baroclinic Rossby radius of deformation to 1 km ORCA025 and ORCA12 can not simulate sub-mesoscale phenomena. Only ORCA36 can simulate the largest sub-mesoscale processes and is able to produce SKE. Configuration: Horizontal grid : tripolar ORCA grid ( 12960 * 10850 points ) Vertical grid: 75 Z-levels, 1 meter at surface Domain Include Antarctic Ice Shelves (explicit resolution) Bathymetry: GEBCO 2019 (GEBCO, 2019) and Bedmachine Antarctica 2 Antarctic ice caps: Bedmachine Antarctica 2 Code: NEMO 4.2 release (including sea-ice SI3 model) Numerical settings: Non-linear free surface (Quasi-eulerian Coordinates formulation) Forcing: ECMWF bulk formulae + Atmospheric pressure gradient. Tracers transport: FCT advection scheme 4th order on horizontal and vertical + Explicite diffusion with iso-neutral operator Dynamic: Advection: flux form - 3rd order UBS + No explicit viscosity Vertical physic: Vertical mixing: k-epsilon vertical mixing (GLS) + adaptive-implicit vertical advection (Shchepetkin 2015) Impact of resolution on waves resolution: A minimum of 2 grid cell per Rossby radius to resolve a wave on a discrete grid (Hallberg, 2013) Global ¼°: eddy-permitting Global 1/12°: eddy-rich Global 1/36°: eddy resolving + able to represent a part of the sub-mesoscale activity: sub-mesoscale permitting. Tides representation in eddy permitting, eddy rich and sub- mesocale permitting global configurations based on NEMO OGCM. Clément Bricaud, Jérôme Chanut, Romain Bourdallé-Badie (Mercator Ocean International), Perrine Abjean (CLS) Contact: cbricaud@mercator-ocean.fr 1. Method: Model configurations and parametrizations 2. Hindcast set up 3. Kinetic Energy representation: spatial decomposition 6. Impact of choices for harmonical analysis on K1 module 11. Conclusion / Next step / Perspectives Abstract In the framework of the Copernicus Marine Environment Monitoring Service, Mercator Ocean International operates a global high-resolution forecasting system at the resolution of 1/12°. Resolving scales below 100 kilometers, and in particular sub mesoscale processes (1-50 km), appears to be essential to better represent the circulation in the open ocean (Chassignet, 2017), and, to improve the large-scale representations thanks to a more explicit energy transfers between finer and larger scales (Fox-Kemper Baylor, 2019). In particular, mixing plays a significant role in shaping the mean state of the ocean. Global internal tides are one of the sources of this mixing. Increasing resolution appears necessary to improve the barotropic tides solution and the baroclinic tides generation. Benefiting from the context of the European H2020 IMMERSE project, a new 1/36° global configuration (2 to 3 km resolution), based on the NEMO 4.2 OGCM, has been developed. Thanks to the resolution increase, this model can resolve the Rossby radius in almost all open oceans areas at global scale quite everywhere and to span a large part of the internal wave spectrum. A hierarchy of multi-year simulations at 1/4°, 1/12° and 1/36° resolution with/without explicit tide representation has been performed: for each resolution, after a 3-years spin up without tidal forcing, 2 twin 3-years runs have been realized: one without tidal forcing and one forced by the 5 tidal components K1, O1, S2, M2, N2. These models are driven at the surface by the 8km/1hour ECMWF IFS system. Atmospheric pressure forcing has been activated. We propose an evaluation | poster |
MaRDI The Mathematical Research Data Initiative M. Reidelbach and M. Weber Cooperation: WIAS, DMV, ITWM, LMU, MPI DCTS, MPI MIS, MFO, TUB, TUKL, TUM, UL, USTUTT, WWU Funding: DFG MaRDI within the National Research Data Infrastructure Structure of MaRDI TA4 – Interdisciplinary Mathematics The 4 Layers of MaRDI [1] The MaRDI consortium. (2022). MaRDI: Mathematical Research Data Initiative Proposal. Zenodo. https://doi.org/10.5281/zenodo.6552436 Publications Key Aims of the NFDI: Systematically catagolize research data from publicly funded research, to secure these for the future and make them findable and accessible. Develop and establish standards in research data management and guarantee the (inter-)national linkage of research data. Key Aims of MaRDI: Establish peer review processes and quality badges for (mathematical) software. Provide knowledge about algorithms in one place and benchmarks for machine learning problems. Standardize interdisciplinary workflows.Data StructuresRepresentation FormatsExchange FormatsAPIsTest CasesMeta-DataPIDsBenchmark FrameworkPre-defined Software EnvironmentsWorkflowsOntologyLink to algorithms, publications, software, and test/data Workflows will be documented FAIR on the MaRDI Portal. Standardized descriptions enable computer-aided math and app queries. Software Hardware Process Steps Input Data Output Data Research Objective Methods Model Soon available in Password: MaRDI Try it out https://doi.org/10.5281/zenodo.6821117 | poster |
D i g i t a l i s a t i o n o f A r t H i s t o r i c a l L a n t e r n S l i d e s : C h a l l e n g e s a n d O p p o r t u n i t i e s Art historical lantern slides are also distinguished by a specific pictorial object: They depict reproductions of art works such as paintings, drawings, sculptures or buildings. Media information layers of the art historical lantern slide: The glass object not only relates to the captured art work, but also to authors, dates, locations, techniques or materials used in the creation of the slide. What ? is an art historical lantern slide Research Project A Million Pictures: Lantern slides consist of two glass plates, one with the image and the other plate added to protect it. They are usually bound together and framed with paper which facilitate handling and prevents the edges from splitting and fingers from being cut. Glass plate negatives do not have this type of frame. [1] Digital Slide Collections are Research Data! Why ? is it important They offer far-reaching insights into the histories of art, questions of canon(s) and collecting, teaching practices and research interests as well as into the history of technology and photography. The digitisation of these slide collections presents an opportunity to preserve, access and use historic images in new ways. Digitalisation of art historical slide collections offers the opportunity to enhance and increase the visibility of those collections, to integrate them into larger national and international research contexts and to share them as research data. Given the contexts of image production and the material properties of the slides, art historical lantern slides are artefacts – unique objects (like objects in museums), that need to be indexed as single items when digitised. Credits: Lantern Slide of Rembrandt, Pilatus Washing his Hands, c.1665, exposed glass plate, cover glass, paper, 8,5 x 10 cm, with annotations by Erwin Panofsky, Dia-Archiv des Kunstgeschichtlichen Seminars der Universität Hamburg, https://kultdokuhh-4.fbkultur.uni-hamburg.de/ Screenshot of the database of the Slide Archive of the Department of Art History, Universität Hamburg References: [1] How to Digitise Slides. Recommendations and Working Lists for the Reproduction of a Very Special Artefact, https://a-million-pictures-recommendations.wp.hum.uu.nl/general-remarks/understanding-the-object/, [9.8.2023]. [2] Anke Napp, Directives for slide digitization. Practical Recommendations, https://www.kulturwissenschaften.uni- hamburg.de/ks/einrichtungen/bildarchive/diaarchiv/diadigitalisierung-anleitung.pdf, [9.8.2023]. [3] Georg Schelbert, Die kunsthistorische Bilddatenbank zwischen digitalisierter Diathek und visuellem Wissensraum, in H. Locher & M. Männig (Hrsg.), Lehrmedien der Kunstgeschichte: Geschichte und Perspektiven kunsthistorischer Medienpraxis, Deutscher Kunstverlag (DKV) 2022. Use a high resolution, static camera; and photograph with both transmitted and incident light. Better use a camera than a scanner. [2] The entire slide object needs to be digitised. Distinguish between the slide object and the image content and index information on both levels. Relevant information to be catalogued: Image Content, (Previous) Owner(s), Manufacturer, Collection, Dates, Locations, Dimensions, Material. These should be indexed as separate entities! Use controlled vocabularies. Use semantic data models! -> Georg Schelbert: “Simple categorisations are not sufficient to adequately represent the media information layers and historical facts grouped around the image content, the photographic object and the collection history of the slide. With semantic models it is possible not only to represent the relationships between objects and actors or the spatial and temporal aspects of events, but also to express complex media contexts.” [3, p. 361] Best Practices To create consistent digitalisation and indexing How ? do you proceed The poster is based on my master's thesis "Challenges and Opport | poster |
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