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tuberculosis_metadata.json

@@ -5,25 +5,25 @@
     "GPL9790_platform": "https://ftp.ncbi.nlm.nih.gov/geo/platforms/GPL9nnn/GPL9790/soft/GPL9790_family.soft.gz",
     "UniProt_H37Rv_proteome": "https://rest.uniprot.org/uniprotkb/stream?query=proteome:UP000001584&fields=accession,reviewed,gene_oln&format=tsv"
   },
-  "download_timestamp": "2026-06-25T13:26:30.281407",
+  "download_timestamp": "2026-06-30T11:57:18.314708",
   "statistics": {
-    "num_samples": 508,
+    "num_samples": 561,
     "num_features": 3814,
     "target_stats": {
       "class_mapping": {
-        "NORMAL": 0,
-        "ABNORMAL": 1
+        "NEG": 0,
+        "POS": 1
       },
       "num_classes": 2,
       "class_names": [
-        "NORMAL",
-        "ABNORMAL"
+        "NEG",
+        "POS"
       ],
       "samples_per_class": {
-        "NORMAL": 159,
-        "ABNORMAL": 349
+        "NEG": 307,
+        "POS": 254
       }
     }
   },
-  "preprocessing_notes": "GSE19433 M. tuberculosis full-proteome antibody microarray (platform GPL9790, log-transformed median spot intensities). The classification target is the patient chest x-ray result (0=NORMAL, 1=ABNORMAL); samples with chest x-ray \"not applicable\" or \"UNKNOWN\" are dropped. Microarray spot ids (block_row_column) are mapped to M. tuberculosis ORFs (Rv locus tags) via the GPL9790 platform table; array-specific segment/alt spots (\"-s1\", \"-alt\") are collapsed to the base locus tag by averaging. Rv locus tags are mapped to UniProt accessions via the H37Rv reference proteome (UP000001584); spots that do not resolve to a UniProt accession are discarded."
+  "preprocessing_notes": "GSE19433 M. tuberculosis full-proteome antibody microarray (platform GPL9790, log-transformed raw intensities without normalization). The classification target is the M. tuberculosis culture result (0=NEG, 1=POS); samples with culture \"not applicable\" are dropped. Microarray spot ids (block_row_column) are mapped to M. tuberculosis ORFs (Rv locus tags) via the GPL9790 platform table; array-specific segment/alt spots (\"-s1\", \"-alt\") are collapsed to the base locus tag by averaging. Rv locus tags are mapped to UniProt accessions via the H37Rv reference proteome (UP000001584); spots that do not resolve to a UniProt accession are discarded."
 }