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- Dataset Summary
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- The EpicNet dataset is a curated integration of peptide and protein epitope records extracted from the Immune Epitope Database (IEDB) and related immunoinformatics resources. It standardizes linear peptide epitope representations, cross-links source molecules, organisms, and taxonomy references, and unifies metadata under consistent ontological mappings.
3
- It supports bioinformatics, machine learning on epitope prediction, and immunotherapy research by providing aligned, structured representations of epitopes, their parent proteins, and associated immune contexts.
4
-
5
- Supported Tasks and Use Cases
6
- Epitope–Protein Mapping — link and analyze how antigenic peptides relate to their source proteins and organisms.
7
-
8
- Sequence-Based Epitope Prediction — train models to predict immunogenic peptide segments.
9
-
10
- Antigen Similarity & Cross-reactivity Studies — compare epitopes across species for vaccine development.
11
-
12
- Knowledge Graph Integration — generate RDF/OWL graphs for ontology-powered immunoinformatics.
13
-
14
- Embedding Generation and Representation Learning using transformers or peptide encoders (e.g., ESM, ProtBERT).
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-
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- Dataset Structure
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- Data Fields
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- Field Description
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- IEDB IRI Canonical IEDB reference for the epitope entry.
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- Object Type Epitope structure classification (e.g., Linear peptide, Fragment, Analog).
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- Name Peptide sequence string (8–35 amino acids typical length).
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- Modified Residue(s) List of modified amino acids, if any.
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- Modifications Type of modification (e.g., phosphorylation, main-chain modification).
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- Starting Position / Ending Position Residue range within the source molecule sequence.
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- Source Molecule Protein name or precursor from which the epitope originates.
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- Source Molecule IRI Accession to protein database such as UniProt or NCBI Protein.
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- Molecule Parent Parent macromolecule, if hierarchically defined (e.g., domain‑level annotation).
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- Source Organism / Source Organism IRI Organism name and taxonomy reference (NCBI Taxon).
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- Species / Species IRI Species-level classification.
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- Epitope Relation Functional or structural relation type (e.g., analog, fragment of natural sequence).
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- Record Count
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- 2,308,224 rows representing peptide–protein associations
33
-
34
- Average peptide length: 835 amino acids
35
-
36
- Approximate dataset size: 85.8 MB (raw TSV) / 156 MB (Parquet)
37
-
38
- Data Sources and Provenance
39
- Primary sources include:
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-
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- IEDB (Immune Epitope Database) — canonical epitope and antigen relationships
42
-
43
- UniProt / NCBI Protein — sequence-level references
44
-
45
- NCBI Taxonomy — standardized organism identifiers
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- Each entry maps identifiers to IEDB IRIs, providing internationally traceable cross‑links.
47
-
48
- Languages and Data Format
49
- Sequence representation: Amino acid single-letter codes (A–Y)
50
-
51
- Metadata fields: English-language labels and ontology-class terms
52
-
53
- Format: TSV / Parquet (CSV-compatible with structured metadata)
54
-
55
- Intended Uses
56
- EpicNet is designed for use in:
57
-
58
- Computational immunology pipelines (e.g., T-cell / B-cell epitope classifier fine-tuning)
59
-
60
- Graph-based representation of immune networks
61
-
62
- Comparative peptide analytics across pathogens and hosts
63
-
64
- Foundation datasets for large-scale protein–epitope pretraining
65
-
66
- Limitations and Ethical Considerations
67
- Dataset reflects experimentally or computationally curated peptide sequences; not all records are experimentally verified.
68
-
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- Certain peptide segments appear across species due to homologs or predicted analogs.
70
-
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- Users must verify NCBI Taxonomy and UniProt IDs for clinical or diagnostic applications.
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-
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- Dataset does not contain personally identifiable data or clinical metadata.
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-
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- Citation
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- If you use this dataset, please cite:
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- Gokul Alex (2025). EpicNet – International Epitope Database Peptide Network. Hugging Face Datasets.
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- Available at: https://huggingface.co/datasets/gokulalex/EpicNet
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-
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- License
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- Creative Commons Attribution 4.0 International (CC BY‑4.0)
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-
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- Dataset Creation and Maintenance
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- Author: Gokul Alex
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- Release Date: October 2025
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- Version: v1.0
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- Contact: huggingface.co/gokulalex
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-
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- Example Entry
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  json
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  {
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  "IEDB IRI": "http://www.iedb.org/epitope/1",
@@ -101,6 +68,6 @@ json
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  "Source Organism": "Streptococcus pyogenes",
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  "Species": "Streptococcus pyogenes serotype M3 D58"
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  }
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- Acknowledgments
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- Data derived from the IEDB Consortium, NCBI, and UniProt KB.
106
- Compilation, integration, and ontology alignment under the EpicNet Data Initiative.
 
1
+ # Dataset Summary
2
+ - The EpicNet dataset is a curated integration of peptide and protein epitope records extracted from the Immune Epitope Database (IEDB) and related immunoinformatics resources. It standardizes linear peptide epitope representations, cross-links source molecules, organisms, and taxonomy references, and unifies metadata under consistent ontological mappings.
3
+ - It supports bioinformatics, machine learning on epitope prediction, and immunotherapy research by providing aligned, structured representations of epitopes, their parent proteins, and associated immune contexts.
4
+
5
+ # Supported Tasks and Use Cases
6
+ - Epitope–Protein Mapping — link and analyze how antigenic peptides relate to their source proteins and organisms.
7
+ - Sequence-Based Epitope Prediction — train models to predict immunogenic peptide segments.
8
+ - Antigen Similarity & Cross-reactivity Studies — compare epitopes across species for vaccine development.
9
+ - Knowledge Graph Integration — generate RDF/OWL graphs for ontology-powered immunoinformatics.
10
+ - Embedding Generation and Representation Learning using transformers or peptide encoders (e.g., ESM, ProtBERT).
11
+
12
+ # Dataset Structure
13
+
14
+ ## Record Count
15
+ - 2,308,224 rows representing peptide–protein associations
16
+ - Average peptide length: 8–35 amino acids
17
+ - Approximate dataset size: 85.8 MB (raw TSV) / 156 MB (Parquet)
18
+
19
+ # Data Sources and Provenance
20
+ - IEDB (Immune Epitope Database) — canonical epitope and antigen relationships
21
+ - UniProt / NCBI Protein — sequence-level references
22
+ - NCBI Taxonomy — standardized organism identifiers
23
+ - Each entry maps identifiers to IEDB IRIs, providing internationally traceable cross‑links.
24
+
25
+ # Languages and Data Format
26
+ - Sequence representation: Amino acid single-letter codes (A–Y)
27
+ - Metadata fields: English-language labels and ontology-class terms
28
+ - Format: TSV / Parquet (CSV-compatible with structured metadata)
29
+
30
+ # Intended Uses
31
+ - Computational immunology pipelines (e.g., T-cell / B-cell epitope classifier fine-tuning)
32
+ - Graph-based representation of immune networks
33
+ - Comparative peptide analytics across pathogens and hosts
34
+ - Foundation datasets for large-scale proteinepitope pretraining
35
+
36
+ # Limitations and Ethical Considerations
37
+ - Dataset reflects experimentally or computationally curated peptide sequences; not all records are experimentally verified.
38
+ - Certain peptide segments appear across species due to homologs or predicted analogs.
39
+ - Users must verify NCBI Taxonomy and UniProt IDs for clinical or diagnostic applications.
40
+ - Dataset does not contain personally identifiable data or clinical metadata.
41
+
42
+ # Citation
43
+ - If you use this dataset, please cite:
44
+ - Gokul Alex (2025). EpicNet – International Epitope Database Peptide Network. Hugging Face Datasets.
45
+ - Available at: https://huggingface.co/datasets/gokulalex/EpicNet
46
+
47
+ # License
48
+ - Creative Commons Attribution 4.0 International (CC BY‑4.0)
49
+
50
+ # Dataset Creation and Maintenance
51
+ - Author: Gokul Alex
52
+ - Release Date: October 2025
53
+ - Version: v1.0
54
+ - Contact: huggingface.co/gokulalex
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+
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+ # Example Entry
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  json
58
  {
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  "IEDB IRI": "http://www.iedb.org/epitope/1",
 
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  "Source Organism": "Streptococcus pyogenes",
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  "Species": "Streptococcus pyogenes serotype M3 D58"
70
  }
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+ # Acknowledgments
72
+ - Data derived from the IEDB Consortium, NCBI, and UniProt KB.
73
+ - Compilation, integration, and ontology alignment under the EpicNet Data Initiative.