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Dataset Summary
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The EpicNet dataset is a curated integration of peptide and protein epitope records extracted from the Immune Epitope Database (IEDB) and related immunoinformatics resources. It standardizes linear peptide epitope representations, cross-links source molecules, organisms, and taxonomy references, and unifies metadata under consistent ontological mappings.
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It supports bioinformatics, machine learning on epitope prediction, and immunotherapy research by providing aligned, structured representations of epitopes, their parent proteins, and associated immune contexts.
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Supported Tasks and Use Cases
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Epitope–Protein Mapping — link and analyze how antigenic peptides relate to their source proteins and organisms.
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Computational immunology pipelines (e.g., T-cell / B-cell epitope classifier fine-tuning)
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Graph-based representation of immune networks
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Comparative peptide analytics across pathogens and hosts
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Foundation datasets for large-scale protein–epitope pretraining
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Limitations and Ethical Considerations
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Dataset reflects experimentally or computationally curated peptide sequences; not all records are experimentally verified.
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Certain peptide segments appear across species due to homologs or predicted analogs.
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Users must verify NCBI Taxonomy and UniProt IDs for clinical or diagnostic applications.
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Dataset does not contain personally identifiable data or clinical metadata.
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Citation
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If you use this dataset, please cite:
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Gokul Alex (2025). EpicNet – International Epitope Database Peptide Network. Hugging Face Datasets.
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Available at: https://huggingface.co/datasets/gokulalex/EpicNet
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License
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Creative Commons Attribution 4.0 International (CC BY‑4.0)
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Dataset Creation and Maintenance
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Author: Gokul Alex
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Release Date: October 2025
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Version: v1.0
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Contact: huggingface.co/gokulalex
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Example Entry
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{
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"IEDB IRI": "http://www.iedb.org/epitope/1",
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"Source Organism": "Streptococcus pyogenes",
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"Species": "Streptococcus pyogenes serotype M3 D58"
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}
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Acknowledgments
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Data derived from the IEDB Consortium, NCBI, and UniProt KB.
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Compilation, integration, and ontology alignment under the EpicNet Data Initiative.
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# Dataset Summary
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- The EpicNet dataset is a curated integration of peptide and protein epitope records extracted from the Immune Epitope Database (IEDB) and related immunoinformatics resources. It standardizes linear peptide epitope representations, cross-links source molecules, organisms, and taxonomy references, and unifies metadata under consistent ontological mappings.
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- It supports bioinformatics, machine learning on epitope prediction, and immunotherapy research by providing aligned, structured representations of epitopes, their parent proteins, and associated immune contexts.
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# Supported Tasks and Use Cases
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- Epitope–Protein Mapping — link and analyze how antigenic peptides relate to their source proteins and organisms.
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- Sequence-Based Epitope Prediction — train models to predict immunogenic peptide segments.
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- Antigen Similarity & Cross-reactivity Studies — compare epitopes across species for vaccine development.
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- Knowledge Graph Integration — generate RDF/OWL graphs for ontology-powered immunoinformatics.
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- Embedding Generation and Representation Learning using transformers or peptide encoders (e.g., ESM, ProtBERT).
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# Dataset Structure
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## Record Count
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- 2,308,224 rows representing peptide–protein associations
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- Average peptide length: 8–35 amino acids
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- Approximate dataset size: 85.8 MB (raw TSV) / 156 MB (Parquet)
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# Data Sources and Provenance
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- IEDB (Immune Epitope Database) — canonical epitope and antigen relationships
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- UniProt / NCBI Protein — sequence-level references
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- NCBI Taxonomy — standardized organism identifiers
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- Each entry maps identifiers to IEDB IRIs, providing internationally traceable cross‑links.
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# Languages and Data Format
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- Sequence representation: Amino acid single-letter codes (A–Y)
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- Metadata fields: English-language labels and ontology-class terms
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- Format: TSV / Parquet (CSV-compatible with structured metadata)
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# Intended Uses
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- Computational immunology pipelines (e.g., T-cell / B-cell epitope classifier fine-tuning)
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- Graph-based representation of immune networks
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- Comparative peptide analytics across pathogens and hosts
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- Foundation datasets for large-scale protein–epitope pretraining
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# Limitations and Ethical Considerations
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- Dataset reflects experimentally or computationally curated peptide sequences; not all records are experimentally verified.
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- Certain peptide segments appear across species due to homologs or predicted analogs.
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- Users must verify NCBI Taxonomy and UniProt IDs for clinical or diagnostic applications.
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- Dataset does not contain personally identifiable data or clinical metadata.
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# Citation
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- If you use this dataset, please cite:
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- Gokul Alex (2025). EpicNet – International Epitope Database Peptide Network. Hugging Face Datasets.
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- Available at: https://huggingface.co/datasets/gokulalex/EpicNet
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# License
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- Creative Commons Attribution 4.0 International (CC BY‑4.0)
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# Dataset Creation and Maintenance
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- Author: Gokul Alex
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- Release Date: October 2025
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- Version: v1.0
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- Contact: huggingface.co/gokulalex
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# Example Entry
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json
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{
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"IEDB IRI": "http://www.iedb.org/epitope/1",
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"Source Organism": "Streptococcus pyogenes",
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"Species": "Streptococcus pyogenes serotype M3 D58"
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}
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# Acknowledgments
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- Data derived from the IEDB Consortium, NCBI, and UniProt KB.
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- Compilation, integration, and ontology alignment under the EpicNet Data Initiative.
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