input_ids
list
attention_mask
list
answer
stringlengths
1
933
start_positions
int64
157
69k
end_positions
int64
184
69.1k
token_type_ids
list
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H7N9
5,591
5,595
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alternative posttranslational and RNA-based antiviral approaches, designer vaccines, immunotherapy and the emerging field of neo-virology.
3,215
3,353
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potent cellular and humoral immune responses that are initiated through toll-like receptor-dependent and independent pathways which induce robust pro-inflammatory cytokine responses
11,409
11,590
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Constant evolution of circulating influenza virus strains and the emergence of new strains
415
505
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[ 3152, 248, 16719, 4433, 275, 2079, 19885, 275, 241, 6429, 8809, 42, 6474, 35, 24290, 9133, 37, 248, 10228, 275, 1495, 18296, 19029, 193, 193, 23252, 1349, 531, 25, 14558, 29373, 26649, 13, 273, 4653, 331, 25, 2671, 5771, 28, 24, 193, ...
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While data bearing on influenza Virus human cell adaptation (e.g., receptor binding) are beginning to be understood at the molecular level, the basis for Viral adaptation to efficient human-to- human spread, the chief prerequisite for pandemic emer- gence, is unknown for any influenza Virus.
29,201
29,490
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cytokines
491
500
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persistent infections
810
831
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colocalized after HTNV infection
16,456
16,488
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1 month later
6,040
6,053
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spread in more than two continents
2,984
3,018
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recent changes in the structure of government funding, 2 new public and private joint ventures and specialist undergraduate and postgraduate courses
502
650
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they used careful bioinformatics analyses to demonstrate that the original claim of multiple HIV insertions into the SARS-CoV-2 is not HIV-1 specific but random
6,197
6,357
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Most of the amino acid differences of RBD are located in the external subdomain,
8,820
8,900
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a minimum of 2 weeks of cough, whoop, or posttussive vomiting
17,093
17,154
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extent of aquaculture is a known risk factor [10] , possibly because water bodies offer routes for transmission and persistence of the virus
17,269
17,409
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1-5 μm
7,557
7,563
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herpes simplex virus (HSV) I-II, varicella zoster virus (VZV), West Nile virus, coxsackievirus, echovirus (subgroup of enterovirus), and corona virus
5,843
5,992
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by mosquitoes
3,319
3,332
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it is cleared from the blood within hours through the reticuloendothelial system (Molenaar et al., 2002) , particularly of the liver and spleen, where it is retained for days (Zou et al., 2004) , potentially activating marginal-zone B-cell responses.
25,552
25,802
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288
21,748
21,751
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An estimated one third of the world’s population (or z500 million persons) were infected and had clinical- ly apparent illnesses
985
1,113
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It investigates the usage of Lopinavir/Ritonavir and Interferon Beta 1B.
15,743
15,815
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21.0 [8.5-34.5] vs 18.0 [6.0-28.0] in Hubei outside Wuhan and 15.0 [4.0-26.0] outside Hubei; P < .001).
2,844
2,947
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ability of the phage to penetrate into brain tissue (Ksendzovsky et al., 2012)
30,008
30,086
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plasma viral load
25,635
25,652
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21 were linked to two clusters in Germany and France, 14 were infected in China
1,925
2,004
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specific bacterial species in the microbiome which may thrive in the inflamed airway environment
23,338
23,434
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active community surveillance
13,076
13,105
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exceptionally high titers of live ANDV in their tissues, with much of the viral replication occurring in hepatocytes
21,302
21,418
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after the conserved peptide signal WAASA at the C-terminal of Gn
5,471
5,535
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pre-existing immunity is a major obstacle of many viralvectored vaccines, such as Ad serotype 5 or herpes simplex virus type 1 (HSV-1), where the rate of seroprevalence to these viruses is very high [40-45 % and 70 % (or more) of the US population, respectively]
21,833
22,095
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examination of the types and roles of viruses and antiviral defences that exist throughout our biosphere.
7,307
7,412
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more than 400,000 children were infected worldwide, mostly through MTCT and 90% of them lived in sub-Saharan Africa.
2,291
2,407
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the best mode of verification of the associations of the virus with the proposed mechanism of viral induced acute exacerbations
34,966
35,093
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Uukuniemi phlebovirus
5,038
5,059
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nfluenza, respiratory syncytial virus (RSV), para-influenza virus (PIV), and adenovirus
3,914
4,001
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voltage-gated Ca(2+) channel (VGCC) inhibitor
1,409
1,454
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As a paramyxovirus, there is no DNA phase in the virus lifecycle reducing concerns of integration events, and the levels of gene expression are driven by the proximity to the leader sequence at the 3' end of the viral genome. This gradient of gene expression enables attenuation through rearrangement of the genome, or by insertion of transgenes within the genome.
23,022
23,386
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4.8 days
1,771
1,779
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In both bat species, the strongest antiviral responses were countered by the virus spreading more quickly from cell to cell. This suggests that bat immune defenses may drive the evolution of faster transmitting viruses, and while bats are well protected from the harmful effects of their own prolific viruses, other creatures like humans are not.
6,368
6,714
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pathogenicity of NDV is largely determined by features of the fusion protein enabling ready attenuation of the vaccine vector
23,396
23,521
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immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
6,702
6,757
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may ultimately be toggled therapeutically
4,724
4,765
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1-3 weeks
4,195
4,204
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because it determines the strength of public health response required.
7,346
7,416
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non-specific protection from subsequent influenza virus infection
20,884
20,949
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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1...
arthropod
395
404
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a virus that had infected over 90 % of adult dromedary camels (DC; Camelus dromedarius) in the KSA [4] , also DCs across the Arabian Peninsula and parts of Africa that are a source of DC imports for the KSA
3,955
4,161
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Adenovirus 5 (Ad5)
8,062
8,080
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by the hemagglutination-inhibition (HI) assay,
3,493
3,539
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MERS-CoV and SARS-CoV.
4,280
4,302
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transparent sharing of information between countries and agencies
5,113
5,178
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HIV-1, hCMV, HSV and KSHV
4,678
4,703
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with an outbreak that occurred among United Nations troops during the Korean conflict between 1951 and 1954
4,055
4,162
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recent findings of viral interaction with the upper airway.
5,683
5,742
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liposomes, nanoparticles, and immunostimulating complexes (ISCOMs)
37,056
37,122
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cytoplasmic
10,797
10,808
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will enable the tapping of useful new biological functions and processes, methods for controlling infection, and the deployment of symbiotic or subclinical viruses in new therapies and biotechnologies that are so crucially needed.
3,429
3,659
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expression of AID
2,230
2,247
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50%
11,218
11,221
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A and B
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2,493
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The review first discusses the anti-viral mechanism of the OAS/RNaseL system and evasion tactics employed by different viruses. This is followed by a review of the RIDD pathway and its potential effect on the stability of viral RNAs.
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59,000 deaths
3,819
3,832
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10 days
1,773
1,780
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disease, hantavirus cardiopulmonary syndrome, HCPS (or hantavirus pulmonary syndrome), was linked to
3,228
3,328
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More studies are needed to explore this possibility and resolve the natural origin of SARS-CoV-2. We should emphasize that, although SARS-CoV-2 shows no evidence of laboratory origin, viruses with such great public health threats must be handled properly in the laboratory and also properly regulated by the scientific community and governments.
7,082
7,427
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veterinarians
2,560
2,573
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mice that had been primed with Salmonella alone, and then boosted with Salmonella expressing tetC, induced much lower anti-tetC responses than mice that had not been primed. This argues strongly that prior immunological immunity to the vector can seriously dampen subsequent antigen-specific humoral responses.
15,478
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50 million deaths worldwide
157
184
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aa
26,501
26,503
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HRVs, coronaviruses (CoV), influenza, respiratory syncytial virus (RSV) and parainfluenza viruses (PIV)
4,174
4,277
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by sensing the cellular damage or distress induced by viroporins
5,244
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The inhibitory effect of pre-existing immunity can also be avoided by masking the Ad vector inside dendritic cells (DCs) (Steffensen et al., 2012) . In addition, mucosal vaccination or administration of higher vaccine doses can overcome pre-existing immunity problems (Alexander et al., 2012; Belyakov et al., 1999; Priddy et al., 2008; Xiang et al., 2003) .
23,859
24,217
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adding two amino acids of Met and Thr to the N-terminus of a CHR-peptide
4,664
4,736
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the pulmonary bed and lymphoid organs
16,823
16,860
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Zinc supplementation
3,167
3,187
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Reservoir-People (RP) transmission network model
1,216
1,264
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a confirmed case was a person with laboratory confirmation of SARS-CoV-2 infection (ECDC recommended two separate SARS-CoV-2 RT-PCR tests), irrespective of clinical signs and symptoms, whereas a probable case was a suspect case for whom testing for SARS-CoV-2 was inconclusive or positive using a pan-coronavirus assay
4,110
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up to 14 days [
5,644
5,659
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at there had been 4000 (95%CI: 1000-9700) cases in Wuhan with symptoms onset by 18 January 2020, and the basic reproduction number (R 0 ) was estimated at 2.6 (95
2,927
3,089
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Though the S1 subunit of 2019-nCoV shares around 70% identity to that of the two bat SARS-like CoVs and human SARS-CoV (Figure 3(A) ), the core domain of RBD (excluding the external subdomain) are highly conserved (
8,590
8,805
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through uptake by regional lymph nodes, perhaps with or within an escorting lung histiocyte
16,255
16,346
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Our model showed that the transmissibility of SARS-CoV-2 was higher than the Middle East respiratory syndrome in the Middle East countries, similar to severe acute respiratory syndrome, but lower than MERS in the Republic of Korea.
1,716
1,947
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pattern recognition receptors (PRRs)
26,976
27,012
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the external subdomain,
8,876
8,899
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colorectal cancer
2,187
2,204
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January 15, 2020
4,421
4,437
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it is generally considered to be as effective as inactivated vaccines and may be more efficacious in children
5,998
6,107
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acellular
2,107
2,116
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The concomitant development of steroid resistance together with recurring or prolong viral infection
19,542
19,642
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as a carrier for peptides with relatively simple secondary structures, which may be stablilized via anchoring to the coat proteins (Henry et al., 2011) . This may be especially true of peptides with poor inherent immunogenicity, which may be increased by high-valency display and phage-associated adjuvanticity
16,387
16,697
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messenger RNA, DNA-based, nanoparticle, synthetic and modified virus-like particle)
10,922
11,005
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break the vicious cycle of escalating therapeutic development costs and trivial escape mutant selection, both quickly and in multiple places.
3,058
3,199
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the 1918 Virus had an intrinsically high Virulence, tem- pered only in those patients who had been born before 1889, e.g., because of exposure to a then-circulating Virus capable of providing partial immunoprotection against the 1918 Virus strain only in persons old enough (>35 years) to have been infected during that prior era
24,099
24,428
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animal MERS-CoV infections
30,299
30,325
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15 years old or above
3,026
3,047
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Persistent high fever, dyspnea and rapid progression to respiratory failure within 2 weeks, together with bilateral consolidations and infiltrates at the same time, are the most frequent clinical manifestations
13,068
13,278
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not applicable
15,881
15,895
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sore throat, fever, couch, running nose, vomiting, body ache, leg pain, nausea, chills, shortness of breath
6,502
6,609
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Learning from the roles of civet in SARS and camel in MERS, hunting for the animal source of 2019-nCoV and its more ancestral virus
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