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2.75k
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5.51k
AlphaFoldDB
stringlengths
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10
Q5FL49
TPIS_LACAC
Triose-phosphate isomerase
Lactobacillus
MSRTPIIAGNWKLHMNPEQTTEFVDAVKGKLPDPSKVESLICAPAVDLDALRKAAEGSNLHIGAENCYFEDEGAYTGETSPKVLKEMGIDYVIIGHSERRGYFHETDEDINKKAKAIFANGMKPIICCGESLETREANKQEDWVVAQIKAALDGLTAEQVSSLVIAYEPIWAIGTGKTASSDQAEEMCKTIRETVKDLYNEETAENVRIQYGGSVKPANVKELMSKPDIDGGLVGGASLDPESFLALVNYQD
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q5FL49
P33226
TORC_ECOLI
Cytochrome c-type protein TorC
Escherichia
MRKLWNALRRPSARWSVLALVAIGIVIGIALIVLPHVGIKVTSTTEFCVSCHSMQPVYEEYKQSVHFQNASGVRAECHDCHIPPDIPGMVKRKLEASNDIYQTFIAHSIDTPEKFEAKRAELAEREWARMKENNSATCRSCHNYDAMDHAKQHPEAARQMKVAAKDNQSCIDCHKGIAHQLPDMSSGFRKQFDELRASANDSGDTLYSIDIKPIYAAKGDKEASGSLLPASEVKVLKRDGDWLQIEITGWTESAGRQRVLTQFPGKRIFVASIRGDVQQQVKTLEKTTVADTNTEWSKLQATAWMKKGDMVNDIKPIWAYADSLYNGTCNQCHGAPEIAHFDANGWIGTLNGMIGFTSLDKREERTLLKYLQMNASDTAGKAHGDKKEEK
Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal domain of TorC, then from the N-terminus to the C-terminus, and finally to TorA. TorC apocytochrome negatively autoregulates the torCAD operon probably by inhibiting the TorS kinase activity.
P33226
A2T334
YCF3_ANGEV
Photosystem I assembly protein Ycf3
Angiopteris
MPRSQRNDNFIDKTFTIVADILLRVIPTTQREKEAFTYYRDGMSAQSEGEYAEALQNYYKAMRLEIDPYDRSYILYNIGLIHTSNGEHAKALEYYSQALERNPSLPQAFNNMAVICHYRGEQAIQQGDPETSEAWFDQAAEYWKQAIALAPSNYIEAQNWLKITGRLKEWV
Essential for the assembly of the photosystem I (PSI) complex. May act as a chaperone-like factor to guide the assembly of the PSI subunits.
A2T334
B0TP00
Y1591_SHEHH
Nucleoid-associated protein Shal_1591
Shewanella
MFGKGGMGNLMKQAQQMQDKMAKVQEEIARMEVTGEAGAGLVKVTMTGSHSVRKVDIDASLLEDDKEMLEDLIAAACNDAARRVEENQKEKMAEVTGGMQLPPGMKMPF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
B0TP00
Q4QJX4
UVRB_HAEI8
Excinuclease ABC subunit B
Haemophilus
MSEKINTKPFILHSDFRPSGDQPQAIEKLAENLTDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLQMMLHLQQGAIIDQRQILAKLAELQYTRNDQAFQRGTFRVRGEIIDIFPAESDDRAVRIELFDDEIERLSLFDPLTGSSFGAVPRFTIYPKTHYVTPRERILDAIENIKKELVSRREYFIKEHKLLEEQRISQRTQFDIEMMNELGYCSGIENYSRYLSGRNEGEPPPTLFDYMPSDAILIIDESHVTVPQIGGMYRGDRSRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGPYELEKSGTEIIDQVVRPTGLLDPLIEIRPVSIQVDDLLSEARQRADKNERVLVTTLTKKMAEDLTDYLDEHGIRVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYADSITKSMEKAITETNRRREKQIKYNEEHGIVPQALNKKVGELLDIGQGANQKAKANKQRGKMAAEPTALYNAPKNAKEYQQQIKKLEQQMYKFAQDLEFEKAAAIRDQLHQLREQFVFDN
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
Q4QJX4
Q3JEI2
TYSY_NITOC
Thymidylate synthase
Nitrosococcus
MKPYLELIQKILDTGVERDDRTGTGTWSIFGHQMRFDLRQGFPLITTKKLHIRAIFIELLWFLRGETNVKYLHDHGVTIWDEWADEQGELGPIYGYQWRSWPLPDGGYLDQMAKTLTQIRNHPHSRRHVVVAYNPACVDEMALPPCHALFQFYVAQGRLSCQLYQRSADVFLGVPFNIASYALLTHLIAQQCDLDVGEFVWTGGDVHLYRNHLEPARLQLTREPLSLPHLRIKRRPPSLFEYQYDDLEIVDYQSYPAIKAAISV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q3JEI2
Q43848
TKTC_SOLTU
Transketolase, chloroplastic
Solanum
MASSSSLTLSQVIFSPSLPRHGSSSSSSPSLSFSTFSGLKSTPFTSSHRRILPSTTVTKQQFSVRASAAVETLEKTDAAIVEKSVNTIRFLAIDAVEKANSGHPGLPMGCAPMGHILYDEVMKYNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDSVQEDDLKSFRQWGSRIPGHPENFETPGVEVTTGPLGQGIANAVGLAVAEKHLAARFNKPDAEIVDHYTYVILGDGCQMEGISNEVCSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTEDVSARFESLGWHVIWVKNGNTGYDEIRAAIKEAKAVKDKPTMIKVTTTIGFGSPNKANSYSVHGSGLGAKEVEATRNNLGWPYEPFHVPEDVKSHWSRHTPEGAALETEWNAKFAEYEKKYAEEAADLKSIITGELPAGWEKALPTYTPESPADATRNLSQQNLNALAKVLPGFLGGSADLASSNMTLLKMFGDFQKNTPEERNLRFGVREHGMGAICNGIALHSLGLIPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHLASFRAMPNILMFRPADGNETAGAYKVAVLKRKTPSILALSRQKLPQLAGTSIEGAAKGGYIVSDNSSGNKPDVILIGTGSELEIAVKAAEELKKEGKTVRVVSFVCWELYDEQSAEYKESVLPSSVTARVSIEAGSTFGWQKFVGDKGKAIGIDGFGASAPADKIYKEFGITAEAVVAAAKQVS
Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively.
Q43848
B5QYE5
THIG_SALEP
Thiazole synthase
Salmonella
MLRIADKTFDSHLFTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAILAPLIEAGVTLLPNTSGAKTAEEAIFAAQLAREALGTNWLKLEIHPDARWLLPDPIETLKAAEALVKQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETKTMLEIIIQQATVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVADDPVMMATAFRLAVEAGLLARQAVPGNRSTYASATSPLTGFLEALA
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
B5QYE5
P54078
TATC_MYCLE
Sec-independent protein translocase protein TatC
Mycobacterium
MRACDLLKRIKQHYRRSRTNPDATMSLIDHLTELRTRLLISLAAIVVTTIFGFIWYSHSIFGLESLGEWLRRPYCSLPQSARADISPDGQCRLLATAPFDQFMLRIKVGMAAGIVLASPVWFYQLWAFITPGLYTKERRFTVAFVVPAAVLFAGGTVLAYLVLSKALGFLLIVGSGVQVTALSGDRYFGFLLNLLVVFGVSFEFPLLIVMLNIAGLLTYQRLKSWRRGLIFAMFVFAAVFTPGSDPFSMTALGAALTVLLELAIQLVRLHDKRRVKHEALIADDEASVIEPPSSIPERSYTATRSHDDVT
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
P54078
Q9V0K1
UPP_PYRAB
UPRTase
Pyrococcus
MIEDKRWKGVYSFEDSPFIMEILTQLRDKNTDSIEFRKGLVKLGRYMGYELTKTMEVEKVKVETPLEETEGIIVKDRRNVVIITVLRAAIPLMEGLIKVFEHARVGIVSAVRGKAPEFKIEMDYVKIPQIKPEDTVIVADPMIATGSTLTRVLGEVKKYGEPKRTIVLGVLAAPEGISKIKSEFPDVEIFVAKIDRELDHKGYILPGLGDAGDRAFGEPLKLSTLPQVHHIE
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Q9V0K1
Q5XAG6
TRMB_STRP6
tRNA(m7G46)-methyltransferase
Streptococcus
MRVRKRKGAEEHLANNPHYVILNPEDAKGRWHDVFGNDRPIHIEVGSGKGGFITGMALKNPDINYIGIDIQLSVLSYALDKVLASEVSNVKLLRVDGSSLTNYFEDGEVDMMYLNFSDPWPKTKHEKRRLTYKDFLDTYKRILPEHGEIHFKTDNRGLFEYSLASFSQYGMTLRQIWLDLHASNYEGNVMTEYEEKFSNKGQVIYRVEANF
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Q5XAG6
Q8FZV9
UREG2_BRUSU
Urease accessory protein UreG 2
Brucella
MKKIPRIGVGGPVGSGKMAIIEAVVPILIKLGYRILVITNDIVTTEDAKHVQRTLKGVLIEDRIVGVETGGCPHTAVREDPSMNLAAVEEMEAKFPDTDLVLLESGGDNLTLTFSPALIDFFIYVIDVAAGDKIPCKNGPGISQSDILVINKTDLAPYVGASLQVMDDDSRMMRGKKPFVFTNCKTNEGIDDLVHLIRENVLFDTEVSKESA
Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
Q8FZV9
Q75WH3
TX24A_MACGS
Neurotoxin magi-10
Macrothele
MKVFSFTVVVVMILSLSAFVLAGDEGDVMKKIVAMEEAVEERACLAEYQKCEGSTVPCCPGLSCSAGRFRKTKLCTK
Inhibits Kv11.1/KCNH2/ERG1, Kv1.1/KCNA1 and Kv1.3/KCNA3 voltage-gated potassium channels and Nav1.7/SCN9A voltage-gated sodium channels . In vivo, intracranial injection into mice causes lack of coordination for 10 min, followed by fast recovery.
Q75WH3
P41388
TBB_VENIN
Beta-tubulin
Venturia
MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKFVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMFDPKNMMAASDFRNGRYLTSSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEASVSEGEEEYDEEAPLEGEE
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P41388
A7I162
THIC_CAMHC
Thiamine biosynthesis protein ThiC
Campylobacter
MRSQWLKNRKNDKTPTQMYYAKNGIITEEMRYVAKIEQMDAEILRSEVARGKTIIPANINHTNLVPMGIGRSLKCKINSNIGSSSVSSGVEEEVEKLKISIKYGADTVMDLSTGGDLNEIRTQIIKNSTVPIGTVPIYQIIHDVGSIENLTISQMLKTIENQAIQGVSYFTIHAGFLLEFMPLVAKRKMGIVSRGGSLMATWMMKNHKENPFFTAFDEILEICAKYDVSLSLGDSLRPGCIYDASDAAQISELKILGDLARRAWTKNVQVMIEGPGHVPFNEIASNMQLERVLCDDAPFYVLGPLPTDIGAGYDHITSAIGGTMAAFSGASMLCYVTPKEHLGLPNAKDVREGIVAHKIAAHIADVALGKKGAIERDHAMSDARYNFDWNKQFELSLDPDRAKEYHDETLPQEVFKEAEFCSMCGPKFCAYKISREISKNSCEFYKECK
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
A7I162
Q328K6
ULAR_SHIDS
HTH-type transcriptional regulator UlaR
Shigella
MTEAQRHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPRWTPMNLHQAQNHDEKVRIAKAASQLVNPGESVVINCGSTAFLLGQEMCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQGSENSLYAGHWMFTSSKGLTAEGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNANPETLQQLEAQGVSILRV
Represses ulaG and the ulaABCDEF operon.
Q328K6
C6DJE0
YIHI_PECCP
Der GTPase-activating protein YihI
Pectobacterium
MNRPVKGAADKAGKPKVKRKTREELEREARERKKDKKHRGHVAGSRTQEKASTDQRSGQRKAADPRIGSKKPVPLGVLDSAVAKPKPKSKPSAPVENVVAAKPTMSPEEELEMLENDSRLDALLDRLDSGETLSAKDQSWVDETLDRIDILMEELGIELGDDDEEEPQEDMLQLLKRNNPKDAF
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
C6DJE0
Q0BTT3
UPPP_GRABC
Undecaprenyl pyrophosphate phosphatase
Granulibacter
MRIESMNAIQAIAIAILQGATELFPVSSLGHAVVLPALLGWSLPQHSQTFLPFLVFLHLGTAAALLLYFWRDWWALFSGVIGFAPAHHVPQARRIFMLLVVATLPAIVVGGLLEHMLRALFESAPIAAFFLVVNGGLLLFGEKLRGAASPYPQTSDHEVTERRALSTLTVMDAFTIGCWQCAALIPGISRSGATIVGGLLRGIDHEASAHFSFLIALPIILGATVLEVPKLLHADIAPGVFQTAALAAVAAGITAWLSTAFLMRYFRDHDSWALKPFAFYCIIAGLGALAWLHFA
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q0BTT3
P57970
UBIA_PASMU
4-HB polyprenyltransferase
Pasteurella
MPISKQKWIAYAQLMRFDKPIGTLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAAGCVINDYADRHIDGAVKRTSKRPLATGAATPEEAKWLFVLLVFCSFILVLFLNTYAIVLSFIAVFLAFIYPFMKRYTHLPQLFLGMAFGWSIPMAYGASIEALPLECWLLFFANLAWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVVLFLATLLFVYQCKLIKDRERESCFKAFLNNNYFGAMVFVAFLFGIFFDKL
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
P57970
A2BLE8
TOP6A_HYPBU
Type II DNA topoisomerase VI subunit A
Hyperthermus
MAEEYVDVVDIEARKKALAVFREKFKEILEQVMRGENPTIMLPKRTLSNTIYDEKRKLLLLGPEKLKRSFFDLHESKKFMQTLLMARIIYEALERNEYPTIRDLYYRGKHTIVYREPGGRRHEENTWDEQRESDAVIRDIEVFTGLLREEMLILSKEKGKVVGNMRIRSGGDIIDLSKMGHGAYAIEPTPDLIEFIDVDAEYVLVVEKDAVFQQLHRIGFWKKHRAILITSAGQPDRATRRFVRRLNEELGLPVYILTDADPYGWYIYSVFKIGSITLSYESERLATPNARFIGVSMTDIFGYKSKKPYLTEQERRNFIIKAKEADIKRAYELKNYKWFQTKKWQIEIDIFLEKKAKLEIEAMTSKGLRFLADKYLPEKIETGDWIE
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
A2BLE8
O15273
TELT_HUMAN
Titin cap protein
Homo
MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
O15273
Q0HZP9
UBIB_SHESR
Ubiquinone biosynthesis protein UbiB
Shewanella
MTLASIRRGYHVIKTLLQYGLDDVLPPKMTPWYFKLARNSLFWIRNKHKGKSGGERLKLAMQELGPVYIKLGQMLSTRRDLLSDEWANELAMLQDKVPPFDGALARQAIEAELKAPIESFFDDFNETPLASASISQVHTATLKSNGKAVVLKVLRPNVEAKIQADLLLMSQTAKVIDYLLGEGNRLRPSEVIEDYRVTILGELNLKLEALNAIKLRNNFLDSDALYIPYVYEEFCYPRLMVMERIYGIPVSDIAALKAQGTNFKLLAERGVELFFTQVFRDNFFHADMHPGNIFISRDHPENPYYIGLDCGIMGTLSEVDKRYLAENFLAFFNRDYHRIAQLYIESGWVSEKTDLQAFEQAIKVVCEPMFNKPLDEISFGHVLLELFRTARHFDIVVQPQLVLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLEQWMAEQVGPKAMFKKVSTKLPYWSDKLPEFPELIYDNLKLGRKLLSSQQQMLDKYLKYQQQAHKSNYLLITSAILLICGTLLFNQDATLWSPYVCLISGAALWIIGWRSRPKNRKF
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
Q0HZP9
Q15035
TRAM2_HUMAN
Translocating chain-associated membrane protein 2
Homo
MAFRRRTKSYPLFSQEFVIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQKVRKEEIPRQLQYICLYLVHIAGAYLLNLSRLGLILLLLQYSTEFLFHTARLFYFADENNEKLFSAWAAVFGVTRLFILTLAVLAIGFGLARMENQAFDPEKGNFNTLFCRLCVLLLVCAAQAWLMWRFIHSQLRHWREYWNEQSAKRRVPATPRLPARLIKRESGYHENGVVKAENGTSPRTKKLKSP
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) .
Q15035
P51854
TKTL1_HUMAN
Transketolase-related protein
Homo
MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
P51854
Q4L5T8
Y1678_STAHJ
UPF0122 protein SH1678
Staphylococcus
MGKNDLVKTLRMNYLFDFYQTLLTEKQRNYMELFYLRDYSLSEIAETFDVSRQAVYDNIRRTGDLVEDYEAKLNLYEKFEQRRKIYDDMKQTLNDSKKLEQYINQLEELE
Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
Q4L5T8
B9DUQ2
TRHO_STRU0
tRNA hydroxylation protein O
Streptococcus
MSEKIRVLLYYKYVPIEDAQAYAAKHLEFCKSIGLKGRIIIADEGINGTVSGDYETTQKYMDWVHSDERFSDLWFKMDEEEEQAFKKMFVRYKKEIVHLGLEDNQFDEDINPLEVTGQYLNPKEFKEALLDEDTIVLDTRNDYEYDLGHFRGAVRPDIRNFRELPQWVRDNKDKFMEKRVVVYCTGGVRCEKFSGWMVREGFKDVGQLHGGIATYGKDPEVQGELWDGAMYVFDERISVPINHVDPTVISKDHFDGRPCERYVNCANPFCNKQIFASEENEAKYVRGCSPECRAHERNRYVSENGLSRQEWAARLEAIGETLPQVETV
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
B9DUQ2
Q96WV0
UREG_SCHPO
Uncharacterized urease accessory protein ureG-like
Schizosaccharomyces
MAIPFLHKGGSDDSTHHHTHDYDHHNHDHHGHDHHSHDSSSNSSSEAARLQFIQEHGHSHDAMETPGSYLKRELPQFNHRDFSRRAFTIGVGGPVGSGKTALLLQLCRLLGEKYSIGVVTNDIFTREDQEFLIRNKALPEERIRAIETGGCPHAAIREDVSGNLVALEELQSEFNTELLLVESGGDNLAANYSRDLADFIIYVIDVSGGDKIPRKGGPGITESDLLIINKTDLAKLVGADLSVMDRDAKKIRENGPIVFAQVKNQVGMDEITELILGAAKSAGALK
Probably facilitates nickel incorporation.
Q96WV0
Q4LCT2
TXA5_ANDAU
Toxin-like peptide AaF1CA5
Androctonus
MMKLMLFSIIVILFSLIGSIHGADVPGNYPLDSSDDTYLCAPLGENPFCIKICRKHGVKYGLMLRLPCWCEYFGKIKNVKI
Probable neurotoxin that inhibits ion channels.
Q4LCT2
Q7W419
UREF_BORPA
Urease accessory protein UreF
Bordetella
MHLSSPALPIGGFSYSQGLEAAIELGLVHDEASTLAWIESQLVTVMARAEAPLWCLLFEAWRAGDDAAAHGWNQWFHASRETRELRQETEQMGRSLARLAQELGWGTAATRAAVAALRPATLPAVHACACAMWALPREAGLGAYVFSWLENQVAAAIKGVPLGQMAGQRMLERLRAGLPAVLADARARAGATPPRLDTFAPQYALVSARHETQFSRLFRS
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Q7W419
Q03ER2
TGT_PEDPA
tRNA-guanine transglycosylase
Pediococcus
MEPAIKYRLIKTDKHTGARLGEIITPHGTFPTPIFMPVGTQATVKAMSPEELEDLGADIILSNTYHLWVRPGEDIVKEGGGLHQFMNWKKGILTDSGGFQVFSLAKLRDITEEGVHFKNELNGANMFLSPEKAIQIENDLGPDIMMSFDECPPYFESYDYVKHSVERTSRWAERGLKAHRNPETQGLFGIIQGAGFEDLRRQSAKDLVSMDFPGYSIGGLSVGESKEEMNRVLDFTTQLIPENKPRYLMGVGSPDALIDGVLRGVDMFDCVLPTRIARNGTCMTSHGRLVVKNAKYARDFTPIDDNCQCYTCRNYTRAYIRHLIKTDETFGLRLTSIHNVYFLVHLMKDVRQAIMDDNLLEFRQNFFEEYGYNKENSKNF
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Q03ER2
P60590
WGRTX_GRARO
Omega-grammotoxin SIA
Grammostola
MKAQIFVVVLGLAALSVLCYGSEADESALHEEIFQLLAASDEVPKPQERDCVRFWGKCSQTSDCCPHLACKSKWPRNICVWDGSVGK
Inhibits P/Q- (Cav2.1/CACNA1A) and N-type (Cav2.2/CACNA1B) voltage-gated calcium channel by modifying voltage-dependent gating . It selectively and reversibly blocks the calcium channels coupled to glutamate release . Also inhibits potassium channels (Kv2.1/KCNB1) with lower affinity . Has also been shown to weakly inhibit Kv11.1/KCNH2/ERG1, Kv1.2/KCNA2, Kv1.3/KCNA3, Nav1.5/SCN5A, Nav1.7/SCN9A and TRPV1 .
P60590
Q0BU78
YIDC_GRABC
Membrane protein YidC
Granulibacter
MDQKRLFLAIAISLGILLGFQGLYRHFVPEPPAAARTATNAGQGKPNNTLGAVPTDATASQSPPPKEGARLAVDAPRVKGSISLVGARFDDLVLRDYHETVDKNSPLVRLLAPLSGDEPYYVEYGWVPEESGIATPGRDTEWKADAATLTPNKPVTLSWDNGAGLTFMLKVAVDADYMFSVTQSVRNTTGKPVVLHPYARVRRDYRPEVEGYTVLHEGLIGVVDGILHEITYKSADSDGAKNNGLAFEHASTGGWAGITDKYWLTALIPDQITSVDFSFRDTKPNGRDGYQVGIISHNPDQVAAGAESASTTHLFAGAKVVSLLDHYQAEYHIPSFWEAVDFGWFWFITRPFFYALDWLYHLVGNFGVAILIFTVLVKAAFYPLASKSYRSMSKMRLLAPKIQSLRERYKDDPTRMQQEVMQLYKAEGANPASGCLPMLLQFPIFFSLYKVIFVTIEMRHAPFFGWIHDLSAVDPTNLFNLFGLLPFDPTHISPFLHLGIWPLIMGGTMYLQQKMNPPMPDPVQARMFQFMPIIFTFMLARFPVGLVIYWSWNNLLSIGQQWLIQRRTKLPRPELAKV
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Q0BU78
P13528
UNC86_CAEEL
Uncoordinated protein 86
Caenorhabditis
MQNTAPVPTTTTASKMQPFNNSLFGSFDDPILNARAAQVALADIDVKNVPQLTNPLMRPHDMFSYSNYFSGIHDTSAATNIYQGLPSSSEPFDASVVVPTSSDDQMTPLQQVMAMQQSYGAPPPFQYNMTHPFSTTSIASSNNLARYPIAPPTSDMDTDPRQLETFAEHFKQRRIKLGVTQADVGKALAHLKMPGVGSLSQSTICRFESLTLSHNNMVALKPILHSWLEKAEEAMKQKDTIGDINGILPNTDKKRKRTSIAAPEKRELEQFFKQQPRPSGERIASIADRLDLKKNVVRVWFCNQRQKQKRDFRSQFRARSAAAVMGPRVMPVLNGNNSNNNLKQGQTTYNGLPGFFD
Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions . Involved in sensory neuron production and function . Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation . In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function . Involved in determining the identity of the serotonergic NSM neurons and the cholinergic IL2 sensory and URA motor neurons . Promotes expression of the cfi-1 transcription factor in the URA and IL2 neurons which in turn activates normal URA and IL2 gene expression . Required to determine the identity of BDU sensory neurons in concert with transcription factor unc-86, regulating expression of a number of genes, including transcription factors ceh-14 and ahr-1, neuropeptides flp-10, nlp-1 and nlp-15, and tyramine receptor-encoding ser-2 . Regulates expression of a number of genes in NSM neurons including bas-1, cat-1, dop-3, mgl-3, nlp-13, scd-2 and ptps-1 . In the IL2 neurons, required for expression of cho-1, gcy-19, klp-6, lag-2, unc-5 and unc-17 . Promotes expression of pkd-2 in the male-specific CEM head neurons . Required for dauer-specific branching of IL2Q neurons and nictation behavior . Controls both the timing and direction of axon outgrowth in HSN neurons . Plays a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the AIM, NSM, HSN and RIH neurons . Involved in regulation of lin-11 expression in the AIZ interneurons, the major interneurons of the olfactory pathway, and is required for odortaxis behavior . Involved in neurite pruning between AIM neurons during larval development by regulating the expression of transcription factor mbr-1 . Required for correct localization of unc-40 .
P13528
O94888
UBXN7_HUMAN
UBX domain-containing protein 7
Homo
MAAHGGSAASSALKGLIQQFTTITGASESVGKHMLEACNNNLEMAVTMFLDGGGIAEEPSTSSASVSTVRPHTEEEVRAPIPQKQEILVEPEPLFGAPKRRRPARSIFDGFRDFQTETIRQEQELRNGGAIDKKLTTLADLFRPPIDLMHKGSFETAKECGQMQNKWLMINIQNVQDFACQCLNRDVWSNEAVKNIIREHFIFWQVYHDSEEGQRYIQFYKLGDFPYVSILDPRTGQKLVEWHQLDVSSFLDQVTGFLGEHGQLDGLSSSPPKKCARSESLIDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEFISVCGSDEEEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPVRTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRYPDGKREQITLPEQAKLLALVKHVQSKGYPNERFELLTNFPRRKLSHLDYDITLQEAGLCPQETVFVQERN
Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.
O94888
Q9FNB3
Y5360_ARATH
Putative BTB/POZ domain-containing protein At5g13600
Arabidopsis
MASLKLGSKSEVFHLSGHTWLCKTGLKPDVMIQVVDESFHLHKFPLLSRSGYLETLFSKASETTCVAQLHDIPGGPETFLLVAKFCYGVRIEVTPENAVSLRCAAEYLQMSENYGDANLIYLTESFLNDHVFVNWEDSIKALEKSCEPKVLPLAEELHIVSRCIGSLAMKACAEDNTSFFNWPISLPEGTTTTTIYWNGIQTKATSENWWFNDVSSFLDLPMYKRFIKTVESRGVNAGIIAASVTHYAKRNLPLLGCSRKSGSPSEEGTNYGDDMYYSHEEQRSLLEEIVELLPGKKCVTSTKFLLRLLRTSMVLHASQVTQETLEKRIGMQLDEAALEDLLIPNMKYSGETLYDTDSVQRILDHFMLTFDSSIVEEKQMMGDSHPLKSITKVASLIDGYLAEVASDENLKLSKFQALGALIPEDVRPMDDGIYRAIDIYIKAHPWLTESEREQLCLLMNCQKLSLEACTHAAQNERLPLRVIVQVLFFEQMRLRTSIAGWLFGSEENNDTSGALEGNKNTNANMVMHGMRERVFELEKECMSMKQDLDKLVKTKEGRNFFSKIFGSRSKTKTSPCGKGGEDALVIPETKN
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Q9FNB3
B1MYE1
YBEY_LEUCK
Endoribonuclease YbeY
Leuconostoc
MDLAIIDQTHDGVSRYHHDLVESVLNFAGEALKLPVNTEMSVTFVNNDEIQRYNRDYRGVDKPTDVISFAIEEGEDDFNIISDDAWTEDIAKNIGDIIVSVDIIGAQAEYLGHSYERELGFLVVHGFLHLNGYDHMLGDAEEKEMFDLQREILDNYGLKR
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
B1MYE1
Q2P0V3
TPIS_XANOM
Triose-phosphate isomerase
Xanthomonas
MRRKIVAGNWKLHGSRAFATELVAKLAAHMPLEGIDVVILPPLPYLGDLIEDFEAHHLSFGAQDVSSNEKGAYTGEVSASMLVDVGAGYGLVGHSERRQYHQESSELVARKFAAAIHAGLTPVLCVGESLEQREAGQTEAILRAQLEPVLALVGSAGFAGAVLAYEPIWAIGTGCTATPEQAQAVHAFLRGEVAKADARIADSLPILYGGSVKPDNAGELFAQPDVDGGLVGGASLVAEDFLAIARAAAAC
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q2P0V3
Q5TC79
ZBT37_HUMAN
Zinc finger and BTB domain-containing protein 37
Homo
MEKGGNIQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQAFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILEGIHFKINVAEVEAELSQTRTKHQERPPESHRVTPNLNRSLSPRHNTPKGNRRGQVSAVLDIRELSPPEESTSPQIIEPSSDVESREPILRINRAGQWYVETGVADRGGRSDDEVRVLGAVHIKTENLEEWLGPENQPSGEDGSSAEEVTAMVIDTTGHGSVGQENYTLGSSGAKVARPTSSEVDRFSPSGSVVPLTERHRARSESPGRMDEPKQPSSQVEESAMMGVSGYVEYLREQEVSERWFRYNPRLTCIYCAKSFNQKGSLDRHMRLHMGITPFVCRMCGKKYTRKDQLEYHIRKHTGNKPFHCHVCGKSFPFQAILNQHFRKNHPGCIPLEGPHSISPETTVTSRGQAEEESPSQEETVAPGEAVQGSVSTTGPD
May be involved in transcriptional regulation.
Q5TC79
A1SJ31
TYSY_NOCSJ
Thymidylate synthase
Nocardioides
MRAYLDLLQRVVDEGVPKGDRTGTGTLSVFGHQMRFDLRAGFPLVTTKKVHTRSVFGELLWFLRGDTNVKWLQDRGITIWDEWADEQGDLGPVYGYQWRSWPTPDGRHVDQIAQVVEQIRDSPDSRRHVVSAWNVADIPDMALAPCHTMFQFYVAPPGPGEESGPGRLSCQLYQRSADVFLGVPFNIASYALLTHMVAQVTGLEVGDFVHTLGDAHLYSNHLDQARLQLTREPRPLPRLVLDSSVTELDAFDLEHIAVEGYDPHPGIKAPIAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
A1SJ31
Q746Q2
YIDC_GEOSL
Membrane protein YidC
Geobacter
MEKRALIAVVLSILFFYGYTALFSPPPKETPKPVATATQSQPAQQVTAAPVPVAVPAQPQPAVAARDVSVDTPAYSVTFSTQGGSIKRLDLKRYHETAGPGGKNVTLVSEDNPSNYTIGLRAPGFGLDQNAVFVPSADALTVGPGEKKQLSFTWVSPAGVTVTKTYNFSGDGYGLEIQYQVTNSGSARVSSPVQTVQTYPLVPKVKESRFETFGPATFAQDKLFEDKVKDLESGAKTHAAPLWSGFADKYFLSAVLAHEGSMAAATIRKTASGYLENTISSPELSLNPGEGRALTYRLFFGPKDIDVLKAQGNSLERAINLGWFAMLAKPLLHSLKFFHNYTGNYGIAIIIITVIIKVIFYPLTHSSYKSMKEMQKLQPKMQQLREKYKNDREAMNRAMMELYQTHKVNPVGGCLPMLVQIPVFFALYKALMFSIELRHAPFMLWITDLAAKDPYYVTPIIMGVTMVIQQKMTPSQMDPVQQKMMMALPVVFTFMFLNFPSGLVLYWLVNNVLTIIQQYYINRSISTAEAK
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Q746Q2
B7VMM4
YCIB_VIBA3
Inner membrane-spanning protein YciB
Vibrio
MKQILDFIPLIIFFALYKMYDIYTATGALIVASAVQIILTYFIYKKVEKMQVITFLMVAVFGGMTIFLHDDNFIKWKVTIVYALFAIGLTVSHIMGKSAIKGMLGKEITLPDSIWGKINWAWTLFFTLCAILNVYVAFNLPLDVWVNFKVFGLLIATFAFTLLTGVYIYKHLPKDQHLPKDKHQQRDQETQNDTQQELSGKNTEEK
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
B7VMM4
P75691
YAHK_ECOLI
Zinc-dependent alcohol dehydrogenase YahK
Escherichia
MKIKAVGAYSAKQPLEPMDITRREPGPNDVKIEIAYCGVCHSDLHQVRSEWAGTVYPCVPGHEIVGRVVAVGDQVEKYAPGDLVGVGCIVDSCKHCEECEDGLENYCDHMTGTYNSPTPDEPGHTLGGYSQQIVVHERYVLRIRHPQEQLAAVAPLLCAGITTYSPLRHWQAGPGKKVGVVGIGGLGHMGIKLAHAMGAHVVAFTTSEAKREAAKALGADEVVNSRNADEMAAHLKSFDFILNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIAGSMIGGIPETQEMLDFCAEHGIVADIEMIRADQINEAYERMLRGDVKYRFVIDNRTLTD
Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use a ketone as substrate. Is a major source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of YahK has yet to be determined.
P75691
Q26503
TPM_SCHHA
Tropomyosin
Schistosoma
MDGIKKKMIAMKLEKENAMERAVQYEELLKKKEEEREKRESEIAELNTKMKQAQIDCDEVQETLQEQMNKLEETDKRATNAEAEVAAMTRRIRLLEEDLEVSSSRLTETLTKLEEASKTAEESERGRKDLEIRSIADDERLNQLEDQQKEAKYIAEDADRKYDEAARKLAIAEVDFKRAEARLEAAESKIVELEEELRVIGNNMKALEISEQESAQREESYEETIRDLTERLKAAEQRATEAERQVSKLQNEVDHLEDDLLAEKERYKALSGELDQTFAELTGY
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Q26503
Q31TC4
ULAA_SHIBS
Ascorbate-specific permease IIC component UlaA
Shigella
MFFNQVMTNAPLLLGIVTCLGYILLRKSVSVIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYGINGAISDTYASMMATIDRMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTGHIMFQQAGLIAVTLFIFGYSMWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSIGHQQQFASWIAYKVAPFLGKKEESVEDLKLPGWLNIFHDNIVSTAIVMTIFFGAILLSFGIDTVQAMAGKVNWTVYILQTGFSFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFAPNAVVWGFMWGTIGQLIAVGILVACGSSILIIPGFIPMFFSNATIGVFANHFGGWRAALKICLVMGMIEIFGCVWAVKLTGMSAWMGMADWSILAPPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Q31TC4
Q3SYZ6
XYLB_BOVIN
Xylulose kinase
Bos
MAERAARHCCLGWDFSTQQVKVVAVDAELSVFYEDSVHFDRDLVEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSVYWKTGASQVLTSLSPDLPLREQLQACFSISNCPVWMDSSTAAQCRQLEAAVGGAQALSLLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPVDYSDGSGMNLLQIQDKVWSQACLGACAPRLEEKLGRPVPSCSIVGAISSYFVQRYGFPPECKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPTPALEGHIFCNPVDPQHYMALLCFKNGSLMREKIRDESASGSWSKFSKALQSTGMGNSGNLGFYFDVMEITPEIIGRHRFTAENHEVSAFPQDVEIRALIEGQFMAKKIHAEALGYRVMPKTKILATGGASHNRDILQVLADVFGAPVYVIDTANSACVGSAYRAFHGPSLLCLVSIY
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.
Q3SYZ6
Q92BC5
TPX_LISIN
Thioredoxin-dependent peroxiredoxin
Listeria
MTQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVCSTQTRKFNEEASNLDNTVVLTISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVIMKELRLLARSVFVVNAKGEIVYTEVVPEGSDHPNYEAAIEAAKKA
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Q92BC5
P42461
THIX_CORGL
Thiamine biosynthesis protein X
Corynebacterium
MSISRTVFGIAATAALSAALVACSPPHQQDSPVQRTNEILTTSQNPTSASSTSTSSATTTSSAPVEEDVEIVVSPAALVDGEQVTFEISGLDPEGGYYAAICDSVANPGNPVPSCTGEMADFTSQAWLSNSQPGATVEIAEDGTATVELEATATGTGLDCTTQACVAKVFGDHTEGFRDVAEVPVTFAAA
Is necessary for biosynthesis of the 4-methyl-5-(beta-hydroxyethyl)thiazol component from which thiamine is formed.
P42461
Q65WC1
TSAC_MANSM
tRNA threonylcarbamoyladenosine biosynthesis protein TsaC
Basfia
MELAQIVERLKKNEVVAYPTEAVFGLGCNPNSKSAVEKLLILKQRPVEKGLILVAHKLDLLLPFIDESRLKQSHWQLLTQQYDCPTTWVVPAKLSVPKFITGQFDSVAVRLCTHPAVAQLCEQTGFALTSTSANLSGLPPCKTAQQVRSQFGEFFPVLDMAVGNAVNPSEIRDIFSRQIFRRG
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
Q65WC1
A6TFL2
TDH_KLEP7
L-threonine 3-dehydrogenase
Klebsiella
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAAAVAKHVGARNVVITDVNEYRLELARKMGVTRAVNVAKENLNDVMAELGMTEGFDVGLEMSGAPPAFRSMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFGIDDFQKGFDAMRSGQSGKVVLSWD
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
A6TFL2
Q223B1
UBID_ALBFT
Polyprenyl p-hydroxybenzoate decarboxylase
Rhodoferax
MAYRDLRDFITQLEHLGELKRVQAEVSPYLEMTALCDRTLRAGGPALLFENPTGHNTPVLGNLFGTTRRVALGMGVNDVSELRQFGHVLASLKEPEAPKGFKELMGLGSLVKTLWAMAPKELRSAPCQEIIWEGADVDLARLPIQHCWPGDVAPLITWGLVITQGPHKARQNLGIYRQQVLARNKVIMRWLAQRGGALDFKEHAALNPGQPYPVCVALGADPATILGAVTPVPDSLSEYQFAGLLRGSRTELVKALGSELRVPAFAEIVLEGHIYPDATHASGFEHALEGPFGDHTGYYNEQDWFPVFTIDRITQRRDPIYHSTYTGKPPDEPAMLALALNELFVPLLQRQYPEITDFYLPPEGCSYRLAVVQIKKSYPGHARRVMFGIWSFLRQFMYTKFIVVVDDDVNIRDWKDVIWAITTRVDPTRDTLLADSTPIDYLDFASPVSGLGSKMGLDATNKWPGETSREWGRPLTMSADVTARVEQVWQTLGL
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
Q223B1
Q2FKX5
TRPD_METHJ
Anthranilate phosphoribosyltransferase
Methanospirillum
MIQDTIRKVVSMQDLAPDEARDLMTSIADGKVTDAQIGSILTALSMKGVTAHEITAFAHVLRDRAVQLKTDTSGTFVDTCGTGGDGAHTFNISTAAALVAAAAGVRVVKHGNRGVSSRSGSADVLEALGIPITLTPEEAAASVSSHNIAFLFAPGYHPAIGRVASARREIGFFSVFNILGPLLNPAGASARLIGVGDTRHIPSITGALANLGVSHAMVVHGDGTDEITITGETEVYELSGGTICRYTLTPEEFGIRRVSRETIAGGSPAENAEIIMDIFSGRKGPCRDIVLLNAAAAIYLGEKATCIYDGYRIAREVVDSGQAYRLVMALRRTT
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q2FKX5
A6ZVR0
URM1_YEAS7
Ubiquitin-related modifier 1
Saccharomyces
MVNVKVEFLGGLDAIFGKQRVHKIKMDKEDPVTVGDLIDHIVSTMINNPNDVSIFIEDDSIRPGIITLINDTDWELEGEKDYILEDGDIISFTSTLHGG
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
A6ZVR0
P43349
TCTP_SOLTU
p23
Solanum
MLVYQDLLTGDELLSDSFPYKEIQNGMLWEVQGKWVVQGAVDVNIGANPSAEGGGEDEGVDDQAVKVVDIVDTFRLQEQPAFDKKQFVTYIKRYIKNLTPKLEGEAQEAFKKNIESATKFLLSKLKDFQFFVGEGMHDDSALVFAYYKDGSADPTFLYLAPGLKEIKC
Involved in calcium binding and microtubule stabilization.
P43349
A6UWW4
TRM56_META3
tRNA ribose 2'-O-methyltransferase aTrm56
Methanococcus
MVVEVLRLGHRWGRDKRISTHVALTSRALGADKILFVSNDDHVKDSVNRIVEQWGGDFKFDVVDSWKQYIWSFKKNNGIVIHLTMYGENINEIMKKIIEKRQEGKDSKNILIIIGAEKVPKEAYELADYNVSVGNQPHSEVAAIAILLDRLFEGSSLYKEYPDAKIKVNPSDRYKSVEIR
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
A6UWW4
Q491V9
UBID_BLOPB
Polyprenyl p-hydroxybenzoate decarboxylase
Candidatus Blochmannia
MKYKDLRDFIKILEHRGDLKRIKFPINPDLEITEIADRTIKSGGPALFFENPTGYTIPVLCNLFGTPNRIALGMGKESILSLRDVGKLLAFLREPELPTGVHDFFSKIPHFRHILHMPIKRVSTAPCQENVWCNQDVDITHMPIMRCWPQDVSPVITWGITITRGLKSKRQNLGIYRQQVLSKNKIIMRWLSHRGGALDFQEWHKNTSERRFPITVALGADPATLIGAVVPIPDTLSEYAFSGLLRGCRTEVIKCISCDLDVPANSEIVLEGYLERDETAIEGPFGDHTGYYNTTAKFPVCTITHITQRNNPIYLSTYTGRPPDEPAILGMAMNEMFIPIIQKQFPEITDFYLPPEGCSYRLAIVTIKKQYIGHAKRIIFGIWSFLKQFMYTKFIIVCDDDINARDWNDVVWAITTRMEPDRDTIIVKNTPIDYLDFSSPISGLGSKIGMDATNKWPGETEREWGIPIKMHDTVRHYIDSIWDKLDI
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
Q491V9
O95801
TTC4_HUMAN
Tetratricopeptide repeat protein 4
Homo
MEQPGQDPTSDDVMDSFLEKFQSQPYRGGFHEDQWEKEFEKVPLFMSRAPSEIDPRENPDLACLQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEAACEDEDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLRGRKVYQIR
May act as a co-chaperone for HSP90AB1 . Promotes Sendai virus (SeV)-induced host cell innate immune responses .
O95801
P0CD94
UQCC3_RAT
Ubiquinol-cytochrome-c reductase complex assembly factor 3
Rattus
MEAARKALAVVAVLGAGGGVGSILFALVTPGELQKQLMLQEMPERDSRRRDEAVRTKELVMATLKDAAATKENVAWRRNWTVRGDGRSA
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.
P0CD94
A2RI47
THIT_LACLM
Thiamine ECF transporter S component ThiT
Lactococcus cremoris subsp. cremoris
MSNSKFNVRLLTEIAFMAALAFIISLIPNTVYGWIIVEIACIPILLLSLRRGLTAGLVGGLIWGILSMITGHAYILSLSQAFLEYLVAPVSLGIAGLFRQKTAPLKLAPVLLGTFVAVLLKYFFHFIAGIIFWSQYAWKGWGAVAYSLAVNGISGILTAIAAFVILIIFVKKFPKLFIHSNY
Probably a thiamine-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
A2RI47
Q6YQR9
YQGF_ONYPE
Putative pre-16S rRNA nuclease
Candidatus Phytoplasma asteris
MLKCQNNASLGLDLGEKTLGIALSQTGIIAQNLKTIFFATHKYDRLIAPLQEIIFQYQIKTIVLGYPKHMNNDIGIKAKISSDFKKTLENKFEQVKVILWDERLSTVQAIQMLKTNNKKKGKILQMKDEIAATIILQNYLDYIKLHTNKEH
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Q6YQR9
P24421
VSDF_SALDU
Virulence protein VsdF
Salmonella
MLRATKVCIYPTPEQAEHLNAQFGAVRFVYSKSLHIKKHAYQRHGVSLTPRKDIKPLLAVAKKFRKFRKFRKYAWLKEYDSIALQQAVINLDVAFSNCFNPKLKARFPMFKRKHGKLLG
Expressed but non-essential protein, involved in the virulence of Salmonellas.
P24421
Q5FNP1
UVRC_GLUOX
Excinuclease ABC subunit C
Gluconobacter
MTDLPPHSSHHPADQGEPLVPAEKKQGVEAIREALKTIPYSPGVYRMLSEKGEVLYVGKALSLKKRVSSYIRINQLPERLRRMVSMTVSMEIVITRTEADALLLEANYIKRMKPRFNILLRDDKSYPWLMLTESHEFPQITKQRGKPVKGATYWGPFANAWAVNQTLNLVQRSFLLRSCSDAVLNSRTRPCLLYQIKRCSAPCVDRISKEDYAELVSEARQFLSGHSTELQQRLVAEMEQASQELNYERAASIRDRIRGFASIQGSSTINPTSINDADIMTIWQEAGQSCIQVFFIRGSRNNGNRAFYPAHAEEETAADVLSAFMIQFYDNKPPPPSILVNCELPEPKLVEEALSIRRGQKVEILRPQRGEKKDVVEHAALNAREALERKLAENTGQRRLLEGVAEVFGLPEIPQRIETYDNSHIMGQAPYGVMVVGGPEGFNKRAYRKYAIKGPVTPGDDFGMMREVMERRFGHRSENGERPEDWPDLLLIDGGLGQFNAVRAVLADLGVTGIPIVAIAKGPDRDAGREWFFTETKSPFQLPPRDPVLYYLQRLRDEAHRFAITTHRAGRSKGLRSSELDHVPGIGAARKKALLNHFGSAKSVRQASLEELENAPGISSSTATAIYGHFHPEWVQKTSADNRSH
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q5FNP1
K7WDC8
TS21I_MAIZE
Terpene synthase 21
Zea
MGERANFLKGEVRKKFEAAAMSAIDAAMLVDAVVHLGIDHCFREEIATALRSVHEDEEGEFGSCDDLHTVAVRFLVLRQHGLWVSADVFDKFRDDKGSFSKSLLCSNPRGLLSLYNAAHMAVTPEEKVLDDAIAFARSHLVEAMIGELRSPMVEQVSRSFDIPLPRFSRRLESMHYIAEYGQEEEGHDAQILELARLEFELVRSLHLRELREICSAEYGATGEEAFAFIANMTENAWRKINQACMEMDPAMLPAFKVAVVDLSRSIEIIYLGGKRDAYTFGSNLKDLVTSLFLKPCA
Inactive selinene synthase.
K7WDC8
P06708
TNNC2_ASTLP
Troponin C, isotype gamma
Astacus
MDTLDEEQLSALKKAFDSFDTDSKGFITPETVGVILRMMGVKISEKNLQQVIAETDEDGSGELEFEEFVELAAKFLIEEDEEALKAELKEAFRIYDKGGDGYITTDVLREILRELDNRLTEDDLDGIIEEVDEDGSGTLDFDEFMEMMSG
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
P06708
Q9HCJ5
ZSWM6_HUMAN
Zinc finger SWIM domain-containing protein 6
Homo
MAERGQQPPPAKRLCCRPGGGGGGGGSSGGGGGAGGGYSSACRPGPRAGGAAAAAACGGGAALGLLPPGKTQSPESLLDIAARRVAEKWPFQRVEERFERIPEPVQRRIVYWSFPRSEREICMYSSFNTGGGAAGGPGDDSGGGGGAGGGGGGGSSSSPAATSAAATSAAAAAAAAAAAAAAAAGAGAPSVGAAGAADGGDETRLPFRRGIALLESGCVDNVLQVGFHLSGTVTEPAIQSEPETVCNVAISFDRCKITSVTCSCGNKDIFYCAHVVALSLYRIRKPDQVKLHLPISETLFQMNRDQLQKFVQYLITVHHTEVLPTAQKLADEILSQNSEINQVHGAPDPTAGASIDDENCWHLDEEQVQEQVKLFLSQGGYHGSGKQLNLLFAKVREMLKMRDSNGARMLTLITEQFMADPRLSLWRQQGTAMTDKYRQLWDELGALWMCIVLNPHCKLEQKASWLKQLKKWNSVDVCPWEDGNHGSELPNLTNALPQGANANQDSSNRPHRTVFTRAIEACDLHWQDSHLQHIISSDLYTNYCYHDDTENSLFDSRGWPLWHEHVPTACARVDALRSHGYPREALRLAIAIVNTLRRQQQKQLEMFRTQKKELPHKNITSITNLEGWVGHPLDPVGTLFSSLMEACRIDDENLSGFSDFTENMGQCKSLEYQHLPAHKFLEEGESYLTLAVEVALIGLGQQRIMPDGLYTQEKVCRNEEQLISKLQEIELDDTLVKIFRKQAVFLLEAGPYSGLGEIIHRESVPMHTFAKYLFTSLLPHDAELAYKIALRAMRLLVLESTAPSGDLTRPHHIASVVPNRYPRWFTLSHIESQQCELASTMLTAAKGDVRRLETVLESIQKNIHSSSHIFKLAQDAFKIATLMDSLPDITLLKVSLELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVYALDSIMQTWFTLFTPTEATSIVATTVMSNSTIVRLHLDCHQQEKLASSARTLALQCAMKDPQNCALSALTLCEKDHIAFETAYQIVLDAATTGMSYTQLFTIARYMEHRGYPMRAYKLATLAMTHLNLSYNQDTHPAINDVLWACALSHSLGKNELAAIIPLVVKSVKCATVLSDILRRCTLTTPGMVGLHGRRNSGKLMSLDKAPLRQLLDATIGAYINTTHSRLTHISPRHYSEFIEFLSKARETFLMAHDGHIQFTQFIDNLKQIYKGKKKLMMLVRERFG
involved in nervous system development, important for striatal morphology and motor regulation.
Q9HCJ5
Q03QE7
TRMB_LEVBA
tRNA(m7G46)-methyltransferase
Levilactobacillus
MRVRNKPWAKGYMADHLDRLVVEPEPLKGNWQSRFPSNQPLFVEIGTGKGQFIIEMARQHPDRNFIGIEIQTSVIAVALKGVVNSGLTNIQLVHTDGEAINTFFEAGEVSGLYLNFSDPWPKKRHTKRRLTSPVFLAHYADVLQPEGQLQFKTDNRGLFEYSLGSLNNFGMVFEGVWLDLHAATDGVEDIQTEYEQKFSKKGPIYQVIAHFPTNN
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Q03QE7
Q0KEH6
UBIE_CUPNH
Demethylmenaquinone methyltransferase
Cupriavidus
MSETHFGFEKVDEAEKADKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQAGVRPGHKVLDIAGGTGDLAKAFAKQAGPTGEVWLTDINESMLRVGRDRLLNKGIVTPVCLCDAERIPFPDNHFDLVTVAFGLRNMTHKDAALAEMRRVVKPGGKVMVLEFSKVWKPLEKAYDVYSFKVLPWLGERVAGDAPSYRYLAESIRMHPDQASLVRLMEHAGLENVEYFNLTAGVVALHVGRKY
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Q0KEH6
Q9CFG8
XYLB_LACLA
Xylulose kinase
Lactococcus
MTYVLGIDLGTSSLKGILMDEVGNLITTKSAEYQIDTPKQGYSEQRPEYWIVALESVLTGLSVEISDFGQQLAGISFSGQMHSLVVLDDNNKPVYPAILWNDVRTSKQCQEITDRLGQRLLEITKNIALEGFTLPKILWLQENEPEVWSRVKKIMLPKDYLSLWLTGNIYTEFSDAAGTLLLDIEKKQWSEEITDAFNIDRRILPELIESTDRTGFVKAEIAERYKLTNEVKVFAGGADNAAAALGVGLINEEVGLISMGTSGVVSAYEPKIADYKGKLHFFNHTVPGACYSMGVTLAAGNSLNWYKETFGKGLSFNELLSEVYTVSPGSEGLLFTPYIVGERTPHFDSKIRGSFIGISAHHEQKHFSRAVLEGITFSLRDSKDIMEKTKNKKFKRLISVGGGAQNPDIMQMQADIFNSEMIRLTVEQGPGLGACMIAAFGCGLFDSLEAVTKAFVHYKEASFIPNPKNVARYEQIYQIWKQVYKNTSEISHQLVEFNDEG
Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.
Q9CFG8
Q65JH8
TRUB_BACLD
tRNA-uridine isomerase
Bacillus
MYNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSGVLPICVGRATKIVEYLTEKSKTYDAEVTLGCSTETEDQTGEVTEKKPVLAPPDEQTVQSVLRSLEGTIEQVPPMYSAVKVGGKKLYEYARAGIEVERPKRTITIHHIELTSEIRHEGDKARFRFVVTCSKGTYVRTLAVTIGEKLGYPAHMSNLVRTASGPFTLDECLTFEDVEGLIADGTLSEKLVPIERALDHLPKWIISDTLAKKVENGAVLETPGSFSHLTSEDRIAVFTEAGRCTAVYYPHPTKTGLLKPAKVLVQKSEQ
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Q65JH8
Q06417
TDA5_YEAST
Topoisomerase I damage affected protein 5
Saccharomyces
MNIDCLCRWVVLPLLRYPLLVALVLRWSLSDSISICLTIYTLLINAFLIANSYIKRSGQVAWKSLREFKNGIVLITGGSKGLGRAIVSQLLQDYSNLTILNVDICPSSVRNTRVKDLICDLSDDEEVAALLNLLKRKYKNEIRLIVNNAGVRANFTGFNGMERDNLDKIFKINTFAPLQFIQELAPSRHSTRQCYIVNIASILGILTPAKVAAYAASKAALIAFHQSYSFELQNEGVRNIRTLLVTPGQLNTEMFAGFKPPRQFFAPVIDITTLAAKIVRYCELGQRGQLNEPFYCSFAHLLMCVPYSLQRIVRSFSRIDCCLPDE
Involved in the resistance to DNA-damaging agents.
Q06417
Q4L4I5
UVRB_STAHJ
Excinuclease ABC subunit B
Staphylococcus
MVEHYPFKLNSEFDPQGDQPQAIEKIVKGVKEGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYSRNDIDFQRGTFRVRGDVVEIFPASREEMCIRVEFFGDEIDRIREVNYLTGEVIREREHFAIFPASHFVTREEKMKIAIERIEKELEERLKELKDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQIRGMFNGDRARKQVLVDHGFRLPSAMDNRPLKFEEFEQKTNQLVYVSATPGPYEIEHTDEMIEQIIRPTGLLDPKIDVRPTKNQIDDLLSEIQERIDRDERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVVVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNEKGEVIMYADKITDSMQYALDETQRRRDIQTAHNEKYGITPKTINKKIHDVISATVDNDETNEKQQTELPKKMTKKERQKTIENIEKEMKKAAKDLDFEKATELRDMLFELKSEG
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
Q4L4I5
P06015
VSA1_TRYBB
Expression-linked copy
Trypanosoma
MVTKERNAALKIVMLVASALTLHPQQALAQTAGRPLADVVGKTLCTYSKTAKRQAANLAQTLQRASSAAKQSRQAQQLAALALAKLPDYKEAAATLLIYATHKIQDAQASIENWTGENTKLVGQAMYSSGRIDELMLLLEGHREDGANGQDKTCLGAAAGGNTVNEFVKTECDTESGHNIEADNSNIGQAATTLSQESTDPEASGGASCKITANLATDYDSHANELPLLGGLLTIHNAGGFKTGQSLQTAAPTNKLISALKNKGAGVAAKLATVTSAAPTSKQELKTLLASKGERAKLQAANDEYNNWKPGAKPEDFDAHIKKVFGAEDGKDSAYAIALEGISIEAPLGGGQTQNKQLYSMQPKDLMAALIGTIAELQTAAATKPACPGHKQTTTESDALCSKIKDANECNSKHFCSYNGTETDSAKKCKYNATKASASDAPVTQAQTTSRSETPAEKCTGKKKDDCKDGCKWEAETCKDSSILLTKNFALSVVSAALVALLF
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
P06015
P05471
YKP5_KLULA
Uncharacterized killer plasmid pGKl-2 protein 5
Kluyveromyces
MIYDKIDTKLIKLGKTNKFSGEEEKSITSLYYEDESFEFSFKNKYVKITKIETNAYGKKFVTIKSKLYADIVEKVAKELDAVSPILSDGSFRATINDATSFSKDVGEYSFYACVSLYFPSIYKDTEKTTLQVYLKEVVVTKIIKNNLEVEFDKLSLAI
The presence of the two linear plasmids, termed pGKL1 and pGKL2, in strains of Kluyveromyces lactis confers the killer phenotype to the host cell, by promoting the secretion of a toxin able to inhibit the growth of sensitive strains.
P05471
Q5HQX0
UVRB_STAEQ
Excinuclease ABC subunit B
Staphylococcus
MVEHVPFKLKSEFEPQGDQPQAIQKIVDGVNEGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSSLFERDDVIIIASVSCIYGLGNPEEYKNLVVSVRVGMEMERSELLRKLVDVQYSRNDIDFQRGTFRVRGDVVEIFPASREEMCIRVEFFGDEIDRIREVNYLTGEVIREREHFTIFPASHFVTREEKMKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQIRGMYNGDRARKQVLIDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYELEHTDEMVEQIIRPTGLLDPKIDVRPTENQIDDLLSEIQDRVDKDERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDAIVGINLLREGIDIPEVSLVVILDADKEGFLRSDRSLIQTIGRAARNDKGEVIMYADKITDSMQYAIDETQRRREIQIAHNKEHGITPKTINKKIHDVISATVESDETNQQQQTELPKKMTKKERQKTIENIEKEMKKAAKDLDFEKATELRDMLFELKAEG
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
Q5HQX0
Q9RJ68
TATA_STRCO
Sec-independent protein translocase protein TatA
Streptomyces albidoflavus group
MFGRLGAPEIILILVVIILLFGAKKLPDMARSLGKSARILKSEAKAMKSEAKADDAAPADPPNPEQSAAQRTIQAAPGDVTSSRPVTEPTDTTKR
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q9RJ68
Q7PYU6
ZGPAT_ANOGA
Zinc finger CCCH-type with G patch domain-containing protein
Anopheles
MSVDELNQSILQYKEQLEQIAQALQLTRDETERSELNKLKSDLIELLELTVESLAATSDDDDAPDTAGRAPPATADNPIDDEFALFMREIKELQTEDSAAGEQAGEQTATEPERQPNDDDADNDDDADDKLDLDGLVGSKCSAPHLHTWGSTAYHNAMVCSLDADDLAHATAKVLFTNPTHREMLPCAYFLEGECRFTDEKCRYSHGEVVRLDQLRDYRAPQFERLRRAGSRALVKQSTRLWCKGTVTEVDFDAKRCKVRLEEGKREQLEVPFEDLLPLDEDEDGQEAAEDSESDTDGADEEEADDEALRKALLVEKSLFHPAPDRRLGEWEEHTRGIGSKIMQKMGYIVGTGLGREGEGIVVPVSAQVLPQGRSLDYCMELREQSNGDKDLFSVEKKLVQLKRQEAKRAAKDYERQRARESKSKDVFSFINEQVFSGAAGGESSRPNRNRPGALSRQELKEHSCKNLNIASLKLSEEIRRTEADVERLKIALTRHRAGTPAADNLLRQIDAKRAEISRMQASEGNISREQQLRSDKKKLTIF
Transcription repressor.
Q7PYU6
Q4V7E0
TRMO_RAT
tRNA methyltransferase O
Rattus
MRGLEKQGPSATAAPCGCAQPALETGNLLTEPIGYLESCFSAKIGTPRQPSICSQSRACLKIRKSIFNNPEHSLMGLEQFSHVWILFVFHKNGHLNYKAKVQPPRLNGAKTGVFSTRSPHRPNAIGLTLAKLEKVEGGAVYLSGIDMIHGTPVLDIKPYIADYDSPQNLEPQTKHHKLRAAGPSDATANSCDQQLLSGCEKAQPCHSTKEKPKCREHRTSDENSQKFRDTSEIQHTLPEDRERAVDLALESSREETMDEPEDQLGPQELKSFLEEGTDRPRKVEGALVLRGSSAETRWDASCHARTADRVPCSVVPSWVKEAPVATLQVRFTPHAEMDLRKLSSGGASQTSFKYFHSAEEAKCAIEAMLSADPRSVYRRKLCEDRLFFFTVDIAHVTCWFGDGFAEVLRIKLASEPVEVADPEESLVALGS
S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA.
Q4V7E0
A4SGX9
TAL_CHLPM
Probable transaldolase
Chlorobium
MKFFIDTADLDEIRSAAELGMLDGVTTNPSLIAKIVKDPSNFTRTDFFDHIAAICDLVDGPVSAEVTSLDTASMIKEGEALAAIHDNVVVKCPLTIDGLKAIRHLSEAGIATNATLVFSPSQAILAAKAGASFVSPFVGRLDDISTDGMALVEDIVDIYDNYGYMAEVIVASVRHPQHVVEAARIGADIATIPFSVISRLAVHPLTESGLKKFMEDASVIKP
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
A4SGX9
F1R013
ZDHC9_DANRE
Zinc finger DHHC domain-containing protein 9
Danio
MSAVMITRKITRKWEKLPGKNTFCCDGRVMMARQKGVFYLTLFLIVGTCSLFFAFECPYLAVHLSPAIPVFAVLLFVFVMAMLLRTSFSDPGVLPRALPEEANFIEMEIEAANGNVLAGQRPPPRIKNVQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVDRFDHHCPWVGNCVGKRNYRYFYLFTLSLSLLTIYIFAFDIVHVVLRSVDSGFVNTLKETPGTVLEVLVCFFTLWSVVGLTGFHTYLISLNQTTNEDIKGSWSGKNRVQNPYSHKNIIKNCCEVLCGPTYPSVLDRRGLMLEDSCSSAPSNGATTVPVNKSSNPATQTTKSSAPLIPNEHTPDEAKPSICSGTQKSSSSPKEEKPSSPISPNAVAPAVIKESTH
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
F1R013
P20005
VSP1_OVOOK
Snake venom serine protease
Ovophis
VIGGDECNINEHRFLAALYD
Thrombin-like snake venom serine protease that releases specifically fibrinopeptide B from fibrinogen (FGB) to form fibrin clots. Shows a preferential cleavage at Arg-|-Gly bonds in fibrinogen beta chains. Cleaves fibrinogen beta chains preferentially to alpha chains.
P20005
B7HH02
TRPA_BACC4
Tryptophan synthase alpha chain
Bacillus cereus group
MGVEKIKAAFENGKKAFIPYVMGGDGGFEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDLPYEEQNIIASLLREVNIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICELIYATKQKEEA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
B7HH02
Q57637
Y173_METJA
Putative transcriptional regulatory protein MJ0173
Methanocaldococcus
MVEDSFLTDTQIKVLKLRKKGLTQEEIAKMLGTSRANISMIEKRAKENIKKAYNTIKIYNRIMAPLSIEIEEGTDVLEIPDIVFKKADEEGIKVKYNTLELIELIKENASEFIEKRTVKKKFKIYILENGDLDVGGS
Putative transcriptional regulator.
Q57637
Q8E4B4
TARI_STRA3
Ribitol-5-phosphate cytidylyltransferase
Streptococcus
MNIGVIFAGGVGRRMNTKGKPKQFLEVHGKPIIVHTIDIFQNTEAIDAVVVVCVSDWLDYMNNLVERFNLTKVKAVVAGGETGQMSIFKGLEAAEQLATDDAVVLIHDGVRPLINEEVINANIKSVKETGSAVTSVRAKETVVLVNDSSKISEVVDRTRSFIAKAPQSFYLSDILSVERDAISKGITDAIDSSTLMGMYNRELTIVEGPYENIKITTPDDFYMFKALYDARENEQIYGM
Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
Q8E4B4
A2T736
ZKSC8_PANTR
Zinc finger protein 192
Pan
MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHENNPLGQEVFRLRFRQLCYQETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTILPEELQTLVKEHQLENGEEVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASAPEPPNTQLQSEATQHKSPVPQESQERAMSTSQSPTRSQKGSSGDQEMTATLLTAGFQTLEKIEDMAVSLIREEWLLDPSQKDLSRDNRPEDFRNVFSLGGETRSENRELASKQVISTGIHPHGETAAKCNGDVIRGLEHEEARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRIHTGEKPYQCNVCGKAFSYRSALLSHQDIHNKVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIHTGEKPYQCNECGKAFIQRSSLIRHQRIHSGEKSESISV
May be involved in transcriptional regulation.
A2T736
P58034
YMGF_ECOLI
Inner membrane protein YmgF
Escherichia
MNNSNNLDYFTLYIIFSIAFMLITLLVILIAKPSTGLGEVLVTINLLNALVWLAINLVNRLRERLVNHRDQQ
Could be involved in cell division. May participate in the stabilization of the cell divisome under specific conditions.
P58034
B3PVV3
TRPA_RHIE6
Tryptophan synthase alpha chain
Rhizobium
MTARMDKRFAELKAEGRPALVTYFMGGDPDYDTSLGIMKALPEAGSDIIELGMPFSDPMADGPAIQLAGQRALKGGQTLKKTLQLAADFRKTDDATPIVMMGYYNPIYIYGVEKFLDDALTAGIDGLIVVDLPPEMDDELCIPAIRKGINFIRLATPTTDEKRLPAVLKNTSGFVYYVSMNGITGSALPDPSLVSGAVQRIKQHTELPVCVGFGVKTAEHAKVIGGSADGVVVGTAIVNQVATSLTKDGKATADTVQAVATLVRGLSSGTRSARLVAAE
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
B3PVV3
B2VHS0
THII_ERWT9
tRNA 4-thiouridine synthase
Erwinia
MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKPYDETLAVVRHWDNIEVRAKDESKRAAIVAELTRIPGIHHILAVEDRPYTDVHHIFEQTLEMNRERIEGKTFCVRVKRRGKHEFSSQDVERYVGGGLNQHVASAQVQLNRPQVTVNLEIEDERLILVTARYEGIGGYPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWKRYGSTHRVRFVAINFEPVVGEILEKVDDGQMGVVLKRMMVRAASKIAERYGVQALVTGEALGQVSSQTLTNLRLIDNASDTLILRPLISHDKEHIIKLAREIGTEDFARTMPEYCGVISKSPTVKAVKAKIEHEEQNFDFAILERMVEEATNVDIREIAEKAQEEVAEVETVASFSHNDVILDIRSNDEQEARPLEVEGVVVKSLPFYKLATQFGDLDQSKSWLLYCERGVMSRLQALYLHEQGFKNVKVYRP
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
B2VHS0
E7CQW6
UGTA1_STABO
UDP-glucosyltransferase A1
Starmerella
MSPSSHKPLILACGLPLSGHIMPVLSLVHGLTDDGYEATVVTGRAFEQKVRDVGADFVPLEGNADFDDHTLDDLVPGRKDMAPSFDRTVQDVEHMMVATLPEQFAAIQRAFKKLSASGRPVVLVSEVLFFGAHPISLGAPGFKPAGWICLGVLPLLIRSDHTLGLDNDRSPEAHAKKLAMNHALEHQIFVKATAKHKEICRELGCTEDPKFIWEHSYIAADKFLQLCPPSLEFSRDHLPSNFKFAGSTPKHRTQFTPPSWWGDVLSAKRVIMVTQGTFAVSYKHLIVPTLEALKDEPDTLTVAILGRRGAKLPDDVVVPENARVIDYFNYDALLPHVDALVYNGGYGGLQHSLSHSVPVVIAGDSEDKPMVASRAEAAGVAIDLKTGLPTVEQIKEAVDSIIGNPKFHEASKKVQMELESHNSLKILEESIEEIASHDFGLLTKSDEETEDIPVKGPALAVSS
Catalyzes the first glycosylation step of sophorolipid biosynthesis, the coupling of glucose to a hydroxylated fatty acid to give rise to a glucolipid . Can glycosylate all hydroxyl fatty acids generated by cytochrome P450 monooxygenases CYP52M1, CYP52N1 and CYP52E3 into their corresponding glucolipids. Main products are 17-O- and 18-O-(beta-D-glucopyranosyl)-octadecenoic acids .
E7CQW6
G3Y417
YANB_ASPNA
Yanuthone D biosynthesis cluster protein B
Aspergillus subgen. Circumdati
MDRIDVHHHFIPPAYVEAFKTTGGDPSGWHLPQWTPESSLSLMDSHNTRTAILSLTAPGTSILAHSPGASATLAREINLYAAKLHNENPTRFGFFASLPHLTPDTIPAAIEEAIYALETLHADGITLYTRYTGTGYLGHDAFAPLWEELNRRKAVVFIHPTNTAADARNRSILVNPALPQPIIDYPHETCRTAVDLITSGTISRNPDVKIILSHGGGTLPILATRAAHLLYDAKLTSISPEDFLEQARSFYFDLALSGNDENMQLLVGRNGFAKGGHVFYGSDFPYAPVSTINKYVRMMEGFSVQGEEVEKAIARDSAVKLFPRFQMPADLRVGKTNNWGAFSACLLLPVGLSALYSVLQSRVHTYST
Decarboxylase; part of the gene cluster that mediates the biosynthesis of yanuthone D, a fungal isoprenoid epoxycyclohexenone that acts as an antibiotic against fungi and bacteria . The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase yanA . 6-MSA is then converted to m-cresol by the decarboxylase yanB . The cytochrome P450 monooxygenase yanC then catalyzes the oxidation of m-cresol to toluquinol . Epoxidation of toluquinol is then performed by the short chain dehydrogenase yanD, with the help of yanE, and a further prenylation by yanG leads to 7-deacetoxyyanuthone A . The next step is the hydroxylation of C-22 of 7-deacetoxyyanuthone A by the cytochrome P450 monooxygenase yanH to yield 22-deacetylyanuthone A . O-Mevalon transferase yanI then attaches mevalon to the hydroxyl group of 22-deacetylyanuthone A to produce yanuthone E . Finally, the FAD-dependent monooxygenase yanF oxidizes the hydroxyl group at C15 of yanuthone E to form yanuthone D . Furthermore, several branching points in the pathway lead to the production of yanuthones F and G from 7-deacetoxyyanuthone A; yanuthones H and I from 22-deacetylyanuthone A; and yanuthone J from yanuthone E .
G3Y417
C3NGV3
VATD_SULIN
V-ATPase subunit D
Sulfolobus
MSQKVLPTKINLIQFRRQLRLITVIKRLLENKREVLLLYLRTYASEYEKIYNEVNEEMKKVYESYLQAVASEGISNIEEIALSQKPSLEVSSSIKVIFGVKVPTIKLDKSTIPSKPFSDVETSPYLSESYEEMTEAFNKIIELVELESTIRSLVSELRKTQRLINSIDNYILPFYRGSIKFIKQILEDRQREEFSRLKIIRRILQRRRESGSG
Produces ATP from ADP in the presence of a proton gradient across the membrane.
C3NGV3
P0DMW8
VKT33_ACTEQ
Kunitz-type proteinase inhibitor AEPI-III
Actinia
NSFCNLPAVVGRCKGYFPRYFYNTEAGKCQRFIYG
Dual-function toxin that inhibits both the serine protease trypsin and voltage-gated potassium channels (Kv).
P0DMW8
Q9X2T1
THIO_PSEAE
Thioredoxin
Pseudomonas
MSEHIVNVTDASFEQDVLKADGPVLVDYWAEWCGPCKMIAPVLDEVARDYQGKLKVCKLNIDENQDTPPKYGVRGIPTLMLFKDGNVEATKVGALSKSQLAAFLDANI
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Q9X2T1
G3FIN9
UGTK5_MANES
Cyanohydrin UDP-glucosyltransferase UGT85K5
Manihot
MGSLASEIPPHAVLVPYPAQGHVNPLMQLGKLLHSRGFYITFVNTEHNHRRLIRSRGQEFIDGLPDFKFEAIPDGLPYTDRDATQHVPSLSDSTRKHCLAPFIDLIAKLKASPDVPPITCIISDGVMAFAIDAARHFGIPEIQFWTTSACGFMAYLHHIELVRRGIVPFKDESFLHDGTLDQPVDFIPGMPNMKLRDMPSFIRVTDVNDIMFDFMGSEAHKSLKADAIILNTYDELEQEVLDAIAARYSKNIYTVGPFILLEKGIPEIKSKAFRSSLWKEDLSCIEWLDKREPDSVVYVNYGCVTTITNEQLNEFAWGLANSKHPFLWIVRPDVVMGESAVLPEEFYEAIKDRGLLVSWVPQDRVLQHPAVGVFLSHCGWNSTIECISGGKPMICWPFFAEQQTNCKYACDVWKTGVELSTNLKREELVSIIKEMMETEIGRERRRRAVEWRKKAEEATSVGGVSYNNFDRFIKEAILQHKTK
UDP-glucosyltransferase catalyzing in planta synthesis of cyanogenic glucosides. Able to glucosylate acetone cyanohydrin and 2-hydroxy-2-methylbutyronitrile, forming linamarin and lotaustralin. Accepts also to some extent, a wide range of potential acceptor substrates, including simple alcohols, flavonoids, isoflavonoids and other hydroxynitriles such as p-hydroxymandelonitrile, mandelonitrile, (E)-4-hydroxy-2-methylbut-2-enenitrile and (E)- 2-(hydroxymethyl)but-2-enenitrile.
G3FIN9
Q5M5E1
TRHO_STRT2
tRNA hydroxylation protein O
Streptococcus
MAKPIRVLLYYKYVPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGEYETTQKYMDYVHSLPGMEDLWFKIDEEEEQAFKKMFVRYKKEIVHLGLEDNNFDSDINPLETTGAYLSPKEFKDALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDHKEEFMDKRVVVYCTGGVRCEKFSGWLVREGYKDVGQLHGGIVTYGKDPEVQGELWDGKLYVFDERIAVDVNHVDPIVVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSENDLSQEEVVERLAAIGESLDVTPA
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
Q5M5E1
P84152
TCTP_PLAKN
Translationally-controlled tumor protein homolog
Plasmodium (Plasmodium)
MKVYKDVFTNDEVCSDSYNQEDPFGIADFREIAFEVKSNKRIKGNDDYGIADNSEEAVDGMGADVEQVIDIVDSFQLTSTSLSKKEYSVYIKNYMQKILKYLEEKKPDRVDVFKTKAQPLIKHILTNFDDFEFYMGESLDMDAGLTYSYYKGEEVTPRFVYISDGLYEEKF
Involved in calcium binding and microtubule stabilization.
P84152
O75348
VATG1_HUMAN
Vacuolar proton pump subunit M16
Homo
MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation .
O75348
B8DNP8
TATA_DESVM
Sec-independent protein translocase protein TatA
Desulfovibrio
MFGIGIQELLVVLVLVLLVFGANKLPEIGGGLGRAIRNFKRATSEPDEIDITPGKKNGKTDKDDKQA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
B8DNP8
F4IY62
UGPA3_ARATH
UDP-glucose pyrophosphorylase 3
Arabidopsis
MANPQASPILHHPQNHLSLFHFRTTTSPRSFSSLHFRKPLLFLSSSSSFSSKLQQSEQQCNNHQVRHVSTVPVEYSTPTPPESDDFLSEIDRLKSLLSKLDVSKDLRRKDAVIDADSRVRRFFSENRGGLSKVFGYLGLNSNEMFLVKCVIAAGQEHALCMNYEEAFGEEEEEYTVRSSVKNALYALVEMIERFDVNSSGYKGRREMGTVLDSEEIAHFRKFLTFLEEIEQFYDCIGGIIGYQVMVLELLHQSSKRRNTNRSQLVEESLGCQYLEMHTPSVLDLTQEEDYASQAALWGIEGLPDLGEIYPLGGAADRLGLIDSETGECLPAAMLAHCGRTLLEGLIRDLQAREFLYFKLYGKQCVTPVAIMTSAAKNNHEHVSSLCERLKWFGRGQSNFRLFEQPLVPAVSAEDGQWIVSKPFVPVSKPGGHGVIWKLAYDKGVFNWFYDHGRKGATVRQVSNVVAATDVTLLALAGIGLRYNKKLGFASCKRNAGATEGINVLMEKKNFDGKWEYGISCIEYTEFDKFDISNRSPSSNGLQADFPANTNILYVDLHSAELIGSSSNAKSLPNMVLNTKKRIEYLDQYGDYHSVMGGRLECTMQNIADNFFNKFPSRCHGSLEDKLDTYIVYNERRKVTSSAKKKKPHASAALHQTPDGALLDILRNGYDLLTECDIKLPMIEANDKYVDSPPPYLILLHPALGPLWEVSRQKFKGGSISSCSELQLEIAEFSWNNVQVDGSLIVTAENAMGSTTPNDNGEPILQYGLRCGKCKLHNVNVVNRGIDWNSKSNVYWRNDVNRLETCKIILHGNAEFEASNVTIEGHHVFEVPDGHKLKITSGNAGLSINLEALKEEVMETGSWYWNYQLNGSHIHLQQVEVSQS
Involved in the biosynthesis of sulfolipids in the chloroplast. Catalyzes the first committed step in sulfolipid biosynthesis. Converts glucose 1-phosphate to UDP-glucose, the precursor of the polar head of sulfolipid. In addition to glucose 1-phosphate, can use galactose 1-phosphate, but with much lower activity. No uridyltransferase activity with other hexose monophosphates. Specific for UTP and cannot use ATP, CTP, and GTP.
F4IY62
Q5M7U7
VSTM5_RAT
V-set and transmembrane domain-containing protein 5
Rattus
MRPPRCVGRTQGIPLGLLAFWVATARCLQSQGVSLYIPRSAINATVQEDILLSVDYICHGVPTIEWEYTPNWGVQKIVEWKPGTPANVSQSHRDRVCTFDNGSIQLFSVGVRDSGYYVITVTEHPGSSQSGTILLHVSEIRYEDLHFVAVFFALLAAVAVVLISLMWVCNQCAYKFQRKRRYKLRESTTEEIEMKDVEC
Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.
Q5M7U7
Q6G547
TRUA_BARHE
tRNA-uridine isomerase I
Bartonella
MPRFKLTLEYDGSNYAGWQRQAELRTIQSALEQALFHFSGQQLTITTAGRTDAGVHATGQVAHVDFEKNWRTHTVRDALNAHLQKQGDNIAILHVQNVPDSFDARFSAIKRHYLFKILNRRSPPALNTKRVWWIPKPLNAQAMHEAAQKLVGKHDFTTFRSAHCQAKSPIRTLERLDVQREGEEIFLYAQARSFLHHQIRSFAGSLMEVGIGRWTTQDLEAALHAKDRTRCGMVAPPSGLYLTKVEY
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Q6G547
A1CQN6
YPI1_ASPCL
Type 1 phosphatases regulator ypi1
Aspergillus subgen. Fumigati
MSRTQQAPMNAGSASGVQVASPLSQDNSTIRVSGTLRLRGDNGTRNNGEDLTTTRHIRWSEDVVDNEGMGKKSSKVCCIYHKDRPVGESSSESDDTDSSSDDCSDCDSDTRIPTHKGDQGGEASSRCSPSRLAERKCGTSCSKRHSKQRSRRHMSPNAYEKMPKFKGQPGKR
Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.
A1CQN6