Gene symbol,Ranking,Annotation & reasoning,Additional note,Data Source TCL1A,1-50,B cell,,"""Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn’s disease"", CD samples collected from terminal ileum (TI) and ascending colon (AC) through endoscopy and surgical" MS4A1,1-50,B cell,, CD79A,1-50,B cell,, BLK,50-100,B cell,, FCRL1,50-100,B cell,, PAX5,50-100,B cell,, TNFRSF13C,50-100,B cell,, CNR2,50-100,B cell,, CD22,50-100,B cell,Mast, FAM129C,100-150,B cell,, VPREB3,100-150,B cell,, BEST4,1-50,BEST4,Canonical marker, CA7,1-50,BEST4,Canonical marker, OTOP2,1-50,BEST4,Canonical marker, CA4,50-100,BEST4,Co-exp with CA7, NBPF19,50-100,BEST4,, NBPF14,50-100,BEST4,, MEIS1,100-150,BEST4,, ADCY5,100-150,BEST4,, SPIB,100-150,BEST4,, AQP8,1-50,Clonocyte,, CEACAM1,1-50,Clonocyte,, AQP8,1-50,Colonocyte,, CA2,50-100,Colonocyte,Multiple cell types, CA1,50-100,Colonocyte,, HMGCS2,50-100,Colonocyte,Multiple cell types, CD24,50-100,Colonocyte,Multiple cell types, MS4A12,100-150,Colonocyte,, SLC37A2,100-150,Colonocyte,, CEACAM7,100-150,Colonocyte,, SLC26A2,100-150,Colonocyte,, TOP2A,1-50,Cycling,, MKI67,1-50,Cycling,, HMGB2,50-100,Cycling,, OLFM4,1-50,Cycling/Stem,, CENPF,50-100,Cycling/Stem,, PRC1,50-100,Cycling/Stem,, CCNB2,50-100,Cycling/Stem,, AURKB,100-150,Cycling/Stem,, GTSE1,100-150,Cycling/Stem,, RRM2,100-150,Cycling/Stem,, CHGB,1-50,EEC,, CHGA,1-50,EEC,, PCSK1N,50-100,EEC,, KCNB2,50-100,EEC,, NEUROD1,50-100,EEC,, FEV,100-150,EEC,, SCG2,100-150,EEC,, SSTR5-AS1,100-150,EEC,, ACKR1,1-50,Endo,Vein, VWF,1-50,Endo,Cannonical endo marker, PECAM1,1-50,Endo,Canonical marker, CLDN5,50-100,Endo,, SOX18,50-100,Endo,, RAMP3,50-100,Endo,, RAMP2,50-100,Endo,, CLEC14A,100-150,Endo,, TIE1,100-150,Endo,, APOB,1-50,Enterocyte,Multiple cell types, APOA4,1-50,Enterocyte,Multiple cell types, APOA1,1-50,Enterocyte,, SLC15A1,50-100,Enterocyte,, SLC6A19,50-100,Enterocyte,, CYP3A4,100-150,Enterocyte,, MTTP,100-150,Enterocyte,, CUBN,100-150,Enterocyte,, SLC10A2,100-150,Enterocyte,, SLC7A9,100-150,Enterocyte,, FABP1,1-50,Epi,Multiple cell types, COL1A2,1-50,Fibro,"Canonical marker, high expression", COL1A1,1-50,Fibro,"Canonical marker, high expression", DCN,1-50,Fibro,"Canonical marker, high expression", COL3A1,50-100,Fibro,, PDGFRA,50-100,Fibro,, MFAP4,50-100,Fibro,, SFRP2,50-100,Fibro,, C1R,100-150,Fibro,, TFF3,1-50,Goblet,"Canonical marker, high expression", MUC2,1-50,Goblet,"Canonical marker, high expression", SPINK4,1-50,Goblet,, ITLN1,50-100,Goblet,, CLCA1,50-100,Goblet,, FCGBP,50-100,Goblet,, BEST2,100-150,Goblet,, DUOX2,1-50,LND,Important cell state in disease, LCN2,1-50,LND,Important cell state in disease, DMBT1,1-50,LND,Important cell state in disease, REG1A,1-50,LND,Important cell state in disease, SAA1,50-100,LND,, NOS2,50-100,LND,, PI3,100-150,LND,, PDZK1IP1,100-150,LND,, CD55,100-150,LND,, CPA3,1-50,Mast,, KIT,1-50,Mast,, CTSG,50-100,Mast,, GATA2,50-100,Mast,, TPSAB1,50-100,Mast,, TPSB2,50-100,Mast,, MS4A2,100-150,Mast,, HDC,100-150,Mast,, C1QA,1-50,Myel,"Canonical myeloid marker, too high expression", C1QB,1-50,Myel,Canonical myeloid marker, C1QC,50-100,Myel,Canonical myeloid marker; co-express with C1QA and C1QB, CSF3R,50-100,Myel,, FPR1,100-150,Myel,, MS4A6A,100-150,Myel,, TYROBP,100-150,Myel,, AIF1,100-150,Myel,, MS4A7,100-150,Myel,, CSF2RA,100-150,Myel,, S100A8,1-50,Neutrophils,, S100A9,1-50,Neutrophils,, NKG7,1-50,NK,, DEFA6,1-50,Paneth,, DEFA5,50-100,Paneth,, ITLN2,100-150,Paneth,, PLA2G2A,100-150,Paneth,, CDKN1C,100-150,Paneth,, IGHA1,1-50,PCs,, JCHAIN,1-50,PCs,, IGHA2,1-50,PCs,, IGKC,50-100,PCs,"Canonical marker, multiple cell types, too high expression", CCR10,50-100,PCs,, MZB1,50-100,PCs,, DERL3,100-150,PCs,, TNFRSF17,100-150,PCs,, AC096579.15,100-150,PCs,, ENAM,100-150,PCs,, LGR5,1-50,Stem,, CD3D,1-50,T,, CD8A,1-50,T,, TRAC,1-50,T,, FOXP3,1-50,T,Tregs, CTLA4,1-50,T,, GZMB,1-50,T,T-cyto, CD4,50-100,T,, CCL5,50-100,T,, CD3E,50-100,T,, CD247,100-150,T,, TRBC1,100-150,T,, AC092580.4,100-150,T,, CD96,100-150,T,, LRMP,1-50,Tuft,, POU2F3,50-100,Tuft,, HPGDS,50-100,Tuft,, SH2D6,100-150,Tuft,, CCDC129,100-150,Tuft,, SH2D7,100-150,Tuft,, PTGS1,100-150,Tuft,,