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In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.
|
[
{
"ade": "acute megaloblastic anaemia",
"drug": "methotrexate"
},
{
"ade": "pneumonitis",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.",
"role": "user"
},
{
"content": "[{'ade': 'acute megaloblastic anaemia', 'drug': 'methotrexate'}, {'ade': 'pneumonitis', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction.
|
[
{
"ade": "cognitive dysfunction",
"drug": "IL-2"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction.",
"role": "user"
},
{
"content": "[{'ade': 'cognitive dysfunction', 'drug': 'IL-2'}]",
"role": "assistant"
}
] |
The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.
|
[
{
"ade": "brain injury",
"drug": "IL-2"
},
{
"ade": "disability",
"drug": "IL-2"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.",
"role": "user"
},
{
"content": "[{'ade': 'brain injury', 'drug': 'IL-2'}, {'ade': 'disability', 'drug': 'IL-2'}]",
"role": "assistant"
}
] |
Anterior ischemic optic neuropathy secondary to interferon alfa.
|
[
{
"ade": "Anterior ischemic optic neuropathy",
"drug": "interferon alfa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Anterior ischemic optic neuropathy secondary to interferon alfa.",
"role": "user"
},
{
"content": "[{'ade': 'Anterior ischemic optic neuropathy', 'drug': 'interferon alfa'}]",
"role": "assistant"
}
] |
Persisent ocular hypertension following intravitreal ranibizumab.
|
[
{
"ade": "Persisent ocular hypertension",
"drug": "ranibizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Persisent ocular hypertension following intravitreal ranibizumab.",
"role": "user"
},
{
"content": "[{'ade': 'Persisent ocular hypertension', 'drug': 'ranibizumab'}]",
"role": "assistant"
}
] |
We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).
|
[
{
"ade": "exogenous lipoid pneumonia",
"drug": "mineral oil"
},
{
"ade": "ELP",
"drug": "mineral oil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).",
"role": "user"
},
{
"content": "[{'ade': 'exogenous lipoid pneumonia', 'drug': 'mineral oil'}, {'ade': 'ELP', 'drug': 'mineral oil'}]",
"role": "assistant"
}
] |
Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.
|
[
{
"ade": "Reversible MR imaging and MR spectroscopy abnormalities",
"drug": "metronidazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Reversible MR imaging and MR spectroscopy abnormalities', 'drug': 'metronidazole'}]",
"role": "assistant"
}
] |
Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.
|
[
{
"ade": "Cardiac hypersensitivity",
"drug": "mesalazine"
},
{
"ade": "myopericarditis",
"drug": "mesalazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.",
"role": "user"
},
{
"content": "[{'ade': 'Cardiac hypersensitivity', 'drug': 'mesalazine'}, {'ade': 'myopericarditis', 'drug': 'mesalazine'}]",
"role": "assistant"
}
] |
Acute coronary syndrome induced by capecitabine therapy.
|
[
{
"ade": "Acute coronary syndrome",
"drug": "capecitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute coronary syndrome induced by capecitabine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute coronary syndrome', 'drug': 'capecitabine'}]",
"role": "assistant"
}
] |
Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.
|
[
{
"ade": "osteomyelitis",
"drug": "infliximab"
},
{
"ade": "osteomyelitis",
"drug": "Infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.",
"role": "user"
},
{
"content": "[{'ade': 'osteomyelitis', 'drug': 'infliximab'}, {'ade': 'osteomyelitis', 'drug': 'Infliximab'}]",
"role": "assistant"
}
] |
A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.
|
[
{
"ade": "lymphadenopathy",
"drug": "sulphasalazine"
},
{
"ade": "fever",
"drug": "sulphasalazine"
},
{
"ade": "hepatitis",
"drug": "sulphasalazine"
},
{
"ade": "constellation of dermatitis",
"drug": "sulphasalazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'lymphadenopathy', 'drug': 'sulphasalazine'}, {'ade': 'fever', 'drug': 'sulphasalazine'}, {'ade': 'hepatitis', 'drug': 'sulphasalazine'}, {'ade': 'constellation of dermatitis', 'drug': 'sulphasalazine'}]",
"role": "assistant"
}
] |
We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.
|
[
{
"ade": "severe hypercalcemia",
"drug": "vitamin D"
},
{
"ade": "vitamin D poisoning",
"drug": "vitamin D"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.",
"role": "user"
},
{
"content": "[{'ade': 'severe hypercalcemia', 'drug': 'vitamin D'}, {'ade': 'vitamin D poisoning', 'drug': 'vitamin D'}]",
"role": "assistant"
}
] |
A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements.
|
[
{
"ade": "dyskinetic movements",
"drug": "risperidone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements.",
"role": "user"
},
{
"content": "[{'ade': 'dyskinetic movements', 'drug': 'risperidone'}]",
"role": "assistant"
}
] |
A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.
|
[
{
"ade": "hypersensitivity",
"drug": "chloramphenicol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity', 'drug': 'chloramphenicol'}]",
"role": "assistant"
}
] |
Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.
|
[
{
"ade": "painful dysesthesia",
"drug": "levodopa"
},
{
"ade": "flexor spasms",
"drug": "levodopa"
},
{
"ade": "anarchic discharges of motor unit potentials",
"drug": "levodopa"
},
{
"ade": "tonic grouped discharges",
"drug": "levodopa"
},
{
"ade": "marked motor hyperactivity",
"drug": "levodopa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.",
"role": "user"
},
{
"content": "[{'ade': 'painful dysesthesia', 'drug': 'levodopa'}, {'ade': 'flexor spasms', 'drug': 'levodopa'}, {'ade': 'anarchic discharges of motor unit potentials', 'drug': 'levodopa'}, {'ade': 'tonic grouped discharges', 'drug': 'levodopa'}, {'ade': 'marked motor hyperactivity', 'drug': 'levodopa'}]",
"role": "assistant"
}
] |
This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.
|
[
{
"ade": "Schneiderian first-rank symptoms",
"drug": "fluvoxamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.",
"role": "user"
},
{
"content": "[{'ade': 'Schneiderian first-rank symptoms', 'drug': 'fluvoxamine'}]",
"role": "assistant"
}
] |
This is the second report of lactic acidosis in a patient on stavudine and lamivudine.
|
[
{
"ade": "lactic acidosis",
"drug": "stavudine"
},
{
"ade": "lactic acidosis",
"drug": "lamivudine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the second report of lactic acidosis in a patient on stavudine and lamivudine.",
"role": "user"
},
{
"content": "[{'ade': 'lactic acidosis', 'drug': 'stavudine'}, {'ade': 'lactic acidosis', 'drug': 'lamivudine'}]",
"role": "assistant"
}
] |
Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.
|
[
{
"ade": "hemolytic-uremic syndrome",
"drug": "mitomycin C"
},
{
"ade": "Pulmonary hemorrhage",
"drug": "mitomycin C"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.",
"role": "user"
},
{
"content": "[{'ade': 'hemolytic-uremic syndrome', 'drug': 'mitomycin C'}, {'ade': 'Pulmonary hemorrhage', 'drug': 'mitomycin C'}]",
"role": "assistant"
}
] |
As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.
|
[
{
"ade": "hematologic side effects",
"drug": "linezolid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.",
"role": "user"
},
{
"content": "[{'ade': 'hematologic side effects', 'drug': 'linezolid'}]",
"role": "assistant"
}
] |
Life-threatening hyponatremia caused by vinblastine.
|
[
{
"ade": "hyponatremia",
"drug": "vinblastine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Life-threatening hyponatremia caused by vinblastine.",
"role": "user"
},
{
"content": "[{'ade': 'hyponatremia', 'drug': 'vinblastine'}]",
"role": "assistant"
}
] |
Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.
|
[
{
"ade": "neutrophilic skin lesions",
"drug": "G-CSF"
},
{
"ade": "Painful",
"drug": "G-CSF"
},
{
"ade": "neutrophilic skin lesions",
"drug": "granulocyte colony-stimulating factor"
},
{
"ade": "Painful",
"drug": "granulocyte colony-stimulating factor"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.",
"role": "user"
},
{
"content": "[{'ade': 'neutrophilic skin lesions', 'drug': 'G-CSF'}, {'ade': 'Painful', 'drug': 'G-CSF'}, {'ade': 'neutrophilic skin lesions', 'drug': 'granulocyte colony-stimulating factor'}, {'ade': 'Painful', 'drug': 'granulocyte colony-stimulating factor'}]",
"role": "assistant"
}
] |
Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.
|
[
{
"ade": "thrombotic microangiopathy",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.",
"role": "user"
},
{
"content": "[{'ade': 'thrombotic microangiopathy', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Seizures associated with fluoxetine therapy.
|
[
{
"ade": "Seizures",
"drug": "fluoxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Seizures associated with fluoxetine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Seizures', 'drug': 'fluoxetine'}]",
"role": "assistant"
}
] |
Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.
|
[
{
"ade": "Gestational diabetes",
"drug": "norethisterone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.",
"role": "user"
},
{
"content": "[{'ade': 'Gestational diabetes', 'drug': 'norethisterone'}]",
"role": "assistant"
}
] |
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.
|
[
{
"ade": "Leukopenia",
"drug": "azathioprine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.",
"role": "user"
},
{
"content": "[{'ade': 'Leukopenia', 'drug': 'azathioprine'}]",
"role": "assistant"
}
] |
We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.
|
[
{
"ade": "IDDM",
"drug": "interferon"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'IDDM', 'drug': 'interferon'}]",
"role": "assistant"
}
] |
In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.
|
[
{
"ade": "DIAN",
"drug": "cefuroxime"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.",
"role": "user"
},
{
"content": "[{'ade': 'DIAN', 'drug': 'cefuroxime'}]",
"role": "assistant"
}
] |
A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.
|
[
{
"ade": "lower leg edema",
"drug": "rosiglitazone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.",
"role": "user"
},
{
"content": "[{'ade': 'lower leg edema', 'drug': 'rosiglitazone'}]",
"role": "assistant"
}
] |
We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.
|
[
{
"ade": "reversible deafness",
"drug": "metronidazole"
},
{
"ade": "tinnitus",
"drug": "metronidazole"
},
{
"ade": "ataxia",
"drug": "metronidazole"
},
{
"ade": "liver abscess",
"drug": "metronidazole"
},
{
"ade": "splenic abscess",
"drug": "metronidazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.",
"role": "user"
},
{
"content": "[{'ade': 'reversible deafness', 'drug': 'metronidazole'}, {'ade': 'tinnitus', 'drug': 'metronidazole'}, {'ade': 'ataxia', 'drug': 'metronidazole'}, {'ade': 'liver abscess', 'drug': 'metronidazole'}, {'ade': 'splenic abscess', 'drug': 'metronidazole'}]",
"role": "assistant"
}
] |
Progressive hypokalemia developed during phosphate treatment.
|
[
{
"ade": "Progressive hypokalemia",
"drug": "phosphate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Progressive hypokalemia developed during phosphate treatment.",
"role": "user"
},
{
"content": "[{'ade': 'Progressive hypokalemia', 'drug': 'phosphate'}]",
"role": "assistant"
}
] |
Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.
|
[
{
"ade": "Hepatotoxicity",
"drug": "choline magnesium trisalicylate"
},
{
"ade": "hepatotoxicity",
"drug": "salicylate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatotoxicity', 'drug': 'choline magnesium trisalicylate'}, {'ade': 'hepatotoxicity', 'drug': 'salicylate'}]",
"role": "assistant"
}
] |
Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.
|
[
{
"ade": "retinal changes",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.",
"role": "user"
},
{
"content": "[{'ade': 'retinal changes', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.
|
[
{
"ade": "urethral prolapse",
"drug": "calcium hydroxylapatite"
},
{
"ade": "granulomatous reaction",
"drug": "calcium hydroxylapatite"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.",
"role": "user"
},
{
"content": "[{'ade': 'urethral prolapse', 'drug': 'calcium hydroxylapatite'}, {'ade': 'granulomatous reaction', 'drug': 'calcium hydroxylapatite'}]",
"role": "assistant"
}
] |
Pulmonary toxicity secondary to procarbazine.
|
[
{
"ade": "Pulmonary toxicity",
"drug": "procarbazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pulmonary toxicity secondary to procarbazine.",
"role": "user"
},
{
"content": "[{'ade': 'Pulmonary toxicity', 'drug': 'procarbazine'}]",
"role": "assistant"
}
] |
Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.
|
[
{
"ade": "severe neuromyeloencephalopathy",
"drug": "Muzolimine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.",
"role": "user"
},
{
"content": "[{'ade': 'severe neuromyeloencephalopathy', 'drug': 'Muzolimine'}]",
"role": "assistant"
}
] |
CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.
|
[
{
"ade": "reproductive endocrine disorders",
"drug": "valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.",
"role": "user"
},
{
"content": "[{'ade': 'reproductive endocrine disorders', 'drug': 'valproate'}]",
"role": "assistant"
}
] |
Heparin-induced hyperkalemia.
|
[
{
"ade": "hyperkalemia",
"drug": "Heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Heparin-induced hyperkalemia.",
"role": "user"
},
{
"content": "[{'ade': 'hyperkalemia', 'drug': 'Heparin'}]",
"role": "assistant"
}
] |
Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.
|
[
{
"ade": "Myelodysplasia",
"drug": "2-deoxycoformycin"
},
{
"ade": "acute myeloid leukemia",
"drug": "2-deoxycoformycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.",
"role": "user"
},
{
"content": "[{'ade': 'Myelodysplasia', 'drug': '2-deoxycoformycin'}, {'ade': 'acute myeloid leukemia', 'drug': '2-deoxycoformycin'}]",
"role": "assistant"
}
] |
Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.
|
[
{
"ade": "acetazolamide intoxication",
"drug": "acetazolamide"
},
{
"ade": "Acute hemorrhagic gastritis",
"drug": "acetazolamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.",
"role": "user"
},
{
"content": "[{'ade': 'acetazolamide intoxication', 'drug': 'acetazolamide'}, {'ade': 'Acute hemorrhagic gastritis', 'drug': 'acetazolamide'}]",
"role": "assistant"
}
] |
The observations suggest that testicular swelling and pain are side effects of desipramine.
|
[
{
"ade": "testicular swelling",
"drug": "desipramine"
},
{
"ade": "pain",
"drug": "desipramine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The observations suggest that testicular swelling and pain are side effects of desipramine.",
"role": "user"
},
{
"content": "[{'ade': 'testicular swelling', 'drug': 'desipramine'}, {'ade': 'pain', 'drug': 'desipramine'}]",
"role": "assistant"
}
] |
Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.
|
[
{
"ade": "gastrointestinal bleeding",
"drug": "tolazoline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.",
"role": "user"
},
{
"content": "[{'ade': 'gastrointestinal bleeding', 'drug': 'tolazoline'}]",
"role": "assistant"
}
] |
This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.
|
[
{
"ade": "eruption",
"drug": "salsalate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.",
"role": "user"
},
{
"content": "[{'ade': 'eruption', 'drug': 'salsalate'}]",
"role": "assistant"
}
] |
A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine.
|
[
{
"ade": "fever",
"drug": "amifostine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine.",
"role": "user"
},
{
"content": "[{'ade': 'fever', 'drug': 'amifostine'}]",
"role": "assistant"
}
] |
CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the "indirect" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.
|
[
{
"ade": "dyskinesias",
"drug": "L-dopa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the \"indirect\" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.",
"role": "user"
},
{
"content": "[{'ade': 'dyskinesias', 'drug': 'L-dopa'}]",
"role": "assistant"
}
] |
We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.
|
[
{
"ade": "elevation of serum transaminases",
"drug": "6-TG"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.",
"role": "user"
},
{
"content": "[{'ade': 'elevation of serum transaminases', 'drug': '6-TG'}]",
"role": "assistant"
}
] |
However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.
|
[
{
"ade": "loss of intracellular potassium",
"drug": "lithium"
},
{
"ade": "cardiac toxicity",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'loss of intracellular potassium', 'drug': 'lithium'}, {'ade': 'cardiac toxicity', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
In a series of 104 cases of intentional or inadvertent use of zidovudine at differing gestations in pregnancy, there were eight spontaneous first trimester abortions, eight therapeutic terminations, and eight cases of fetal abnormality occurring among a total of 88 cases where the pregnancy progressed.
|
[
{
"ade": "first trimester abortions",
"drug": "zidovudine"
},
{
"ade": "fetal abnormality",
"drug": "zidovudine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In a series of 104 cases of intentional or inadvertent use of zidovudine at differing gestations in pregnancy, there were eight spontaneous first trimester abortions, eight therapeutic terminations, and eight cases of fetal abnormality occurring among a total of 88 cases where the pregnancy progressed.",
"role": "user"
},
{
"content": "[{'ade': 'first trimester abortions', 'drug': 'zidovudine'}, {'ade': 'fetal abnormality', 'drug': 'zidovudine'}]",
"role": "assistant"
}
] |
We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.
|
[
{
"ade": "accelerated nodulosis",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.",
"role": "user"
},
{
"content": "[{'ade': 'accelerated nodulosis', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.
|
[
{
"ade": "diffuse papular eruption",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.",
"role": "user"
},
{
"content": "[{'ade': 'diffuse papular eruption', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.
|
[
{
"ade": "skin lesions",
"drug": "rifampicin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.",
"role": "user"
},
{
"content": "[{'ade': 'skin lesions', 'drug': 'rifampicin'}]",
"role": "assistant"
}
] |
CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.
|
[
{
"ade": "agitation",
"drug": "fentanyl"
},
{
"ade": "tachycardia",
"drug": "citalopram"
},
{
"ade": "myoclonic jerks",
"drug": "fentanyl"
},
{
"ade": "tremors",
"drug": "fentanyl"
},
{
"ade": "tachycardia",
"drug": "fentanyl"
},
{
"ade": "myoclonic jerks",
"drug": "citalopram"
},
{
"ade": "unsteady gait",
"drug": "citalopram"
},
{
"ade": "confusion",
"drug": "citalopram"
},
{
"ade": "agitation",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "fentanyl"
},
{
"ade": "unsteady gait",
"drug": "fentanyl"
},
{
"ade": "tremors",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "confusion",
"drug": "fentanyl"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.",
"role": "user"
},
{
"content": "[{'ade': 'agitation', 'drug': 'fentanyl'}, {'ade': 'tachycardia', 'drug': 'citalopram'}, {'ade': 'myoclonic jerks', 'drug': 'fentanyl'}, {'ade': 'tremors', 'drug': 'fentanyl'}, {'ade': 'tachycardia', 'drug': 'fentanyl'}, {'ade': 'myoclonic jerks', 'drug': 'citalopram'}, {'ade': 'unsteady gait', 'drug': 'citalopram'}, {'ade': 'confusion', 'drug': 'citalopram'}, {'ade': 'agitation', 'drug': 'citalopram'}, {'ade': 'serotonin syndrome', 'drug': 'fentanyl'}, {'ade': 'unsteady gait', 'drug': 'fentanyl'}, {'ade': 'tremors', 'drug': 'citalopram'}, {'ade': 'serotonin syndrome', 'drug': 'citalopram'}, {'ade': 'confusion', 'drug': 'fentanyl'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.
|
[
{
"ade": "cardiac complications",
"drug": "amphotericin B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.",
"role": "user"
},
{
"content": "[{'ade': 'cardiac complications', 'drug': 'amphotericin B'}]",
"role": "assistant"
}
] |
Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.
|
[
{
"ade": "abnormal liver function tests",
"drug": "cyproterone acetate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.",
"role": "user"
},
{
"content": "[{'ade': 'abnormal liver function tests', 'drug': 'cyproterone acetate'}]",
"role": "assistant"
}
] |
Tuberculous uveitis after treatment with etanercept.
|
[
{
"ade": "Tuberculous uveitis",
"drug": "etanercept"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tuberculous uveitis after treatment with etanercept.",
"role": "user"
},
{
"content": "[{'ade': 'Tuberculous uveitis', 'drug': 'etanercept'}]",
"role": "assistant"
}
] |
Unusual pigmentary changes associated with 5-fluorouracil therapy.
|
[
{
"ade": "pigmentary changes",
"drug": "5-fluorouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Unusual pigmentary changes associated with 5-fluorouracil therapy.",
"role": "user"
},
{
"content": "[{'ade': 'pigmentary changes', 'drug': '5-fluorouracil'}]",
"role": "assistant"
}
] |
METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.
|
[
{
"ade": "HUS",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.",
"role": "user"
},
{
"content": "[{'ade': 'HUS', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.
|
[
{
"ade": "Fatal outcome",
"drug": "formalin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal outcome', 'drug': 'formalin'}]",
"role": "assistant"
}
] |
Reversible cardiomyopathy caused by administration of interferon alpha.
|
[
{
"ade": "Reversible cardiomyopathy",
"drug": "interferon alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversible cardiomyopathy caused by administration of interferon alpha.",
"role": "user"
},
{
"content": "[{'ade': 'Reversible cardiomyopathy', 'drug': 'interferon alpha'}]",
"role": "assistant"
}
] |
After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.
|
[
{
"ade": "gastric-outlet obstruction",
"drug": "prostaglandin E1"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.",
"role": "user"
},
{
"content": "[{'ade': 'gastric-outlet obstruction', 'drug': 'prostaglandin E1'}]",
"role": "assistant"
}
] |
Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.
|
[
{
"ade": "potential hazards",
"drug": "mineral oil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.",
"role": "user"
},
{
"content": "[{'ade': 'potential hazards', 'drug': 'mineral oil'}]",
"role": "assistant"
}
] |
We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.
|
[
{
"ade": "crystalluria",
"drug": "sulfadiazine"
},
{
"ade": "renal failure",
"drug": "sulfadiazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.",
"role": "user"
},
{
"content": "[{'ade': 'crystalluria', 'drug': 'sulfadiazine'}, {'ade': 'renal failure', 'drug': 'sulfadiazine'}]",
"role": "assistant"
}
] |
Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.
|
[
{
"ade": "renal tubular acidosis",
"drug": "foscarnet"
},
{
"ade": "nephrogenic diabetes insipidus",
"drug": "foscarnet"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.",
"role": "user"
},
{
"content": "[{'ade': 'renal tubular acidosis', 'drug': 'foscarnet'}, {'ade': 'nephrogenic diabetes insipidus', 'drug': 'foscarnet'}]",
"role": "assistant"
}
] |
Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.
|
[
{
"ade": "necrotizing fasciitis",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.",
"role": "user"
},
{
"content": "[{'ade': 'necrotizing fasciitis', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.
|
[
{
"ade": "thrombosis",
"drug": "prednisone"
},
{
"ade": "thrombosis",
"drug": "cyclosporin"
},
{
"ade": "thrombosis",
"drug": "azathioprine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.",
"role": "user"
},
{
"content": "[{'ade': 'thrombosis', 'drug': 'prednisone'}, {'ade': 'thrombosis', 'drug': 'cyclosporin'}, {'ade': 'thrombosis', 'drug': 'azathioprine'}]",
"role": "assistant"
}
] |
A 57-year-old man developed morphea while taking bromocriptine.
|
[
{
"ade": "morphea",
"drug": "bromocriptine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 57-year-old man developed morphea while taking bromocriptine.",
"role": "user"
},
{
"content": "[{'ade': 'morphea', 'drug': 'bromocriptine'}]",
"role": "assistant"
}
] |
We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.
|
[
{
"ade": "psoriasis",
"drug": "interferon-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.",
"role": "user"
},
{
"content": "[{'ade': 'psoriasis', 'drug': 'interferon-alpha'}]",
"role": "assistant"
}
] |
Multiple seizures after bupropion overdose in a small child.
|
[
{
"ade": "Multiple seizures",
"drug": "bupropion"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multiple seizures after bupropion overdose in a small child.",
"role": "user"
},
{
"content": "[{'ade': 'Multiple seizures', 'drug': 'bupropion'}]",
"role": "assistant"
}
] |
BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.
|
[
{
"ade": "ASPPC",
"drug": "IVTA"
},
{
"ade": "ASPPC",
"drug": "triamcinolone acetonide"
},
{
"ade": "acute syphilitic posterior placoid chorioretinitis",
"drug": "triamcinolone acetonide"
},
{
"ade": "acute syphilitic posterior placoid chorioretinitis",
"drug": "IVTA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.",
"role": "user"
},
{
"content": "[{'ade': 'ASPPC', 'drug': 'IVTA'}, {'ade': 'ASPPC', 'drug': 'triamcinolone acetonide'}, {'ade': 'acute syphilitic posterior placoid chorioretinitis', 'drug': 'triamcinolone acetonide'}, {'ade': 'acute syphilitic posterior placoid chorioretinitis', 'drug': 'IVTA'}]",
"role": "assistant"
}
] |
Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.
|
[
{
"ade": "acute leukemia",
"drug": "hydroxyurea"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.",
"role": "user"
},
{
"content": "[{'ade': 'acute leukemia', 'drug': 'hydroxyurea'}]",
"role": "assistant"
}
] |
We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU.
|
[
{
"ade": "squamous-cell carcinoma",
"drug": "5-FU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU.",
"role": "user"
},
{
"content": "[{'ade': 'squamous-cell carcinoma', 'drug': '5-FU'}]",
"role": "assistant"
}
] |
The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.
|
[
{
"ade": "submassive hepatic necrosis",
"drug": "barbiturates"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.",
"role": "user"
},
{
"content": "[{'ade': 'submassive hepatic necrosis', 'drug': 'barbiturates'}]",
"role": "assistant"
}
] |
Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.
|
[
{
"ade": "Neutropenia",
"drug": "captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.",
"role": "user"
},
{
"content": "[{'ade': 'Neutropenia', 'drug': 'captopril'}]",
"role": "assistant"
}
] |
The disease-modifying drugs he was taking, cyclosporin and methotrexate, were stopped, and the lymphoma resolved spontaneously without the use of chemotherapy.
|
[
{
"ade": "lymphoma",
"drug": "cyclosporin"
},
{
"ade": "lymphoma",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The disease-modifying drugs he was taking, cyclosporin and methotrexate, were stopped, and the lymphoma resolved spontaneously without the use of chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'lymphoma', 'drug': 'cyclosporin'}, {'ade': 'lymphoma', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Acute myocardial necrosis during administration of amsacrine.
|
[
{
"ade": "Acute myocardial necrosis",
"drug": "amsacrine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute myocardial necrosis during administration of amsacrine.",
"role": "user"
},
{
"content": "[{'ade': 'Acute myocardial necrosis', 'drug': 'amsacrine'}]",
"role": "assistant"
}
] |
Bowel perforation associated with intraperitoneal chromic phosphate instillation.
|
[
{
"ade": "Bowel perforation",
"drug": "chromic phosphate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bowel perforation associated with intraperitoneal chromic phosphate instillation.",
"role": "user"
},
{
"content": "[{'ade': 'Bowel perforation', 'drug': 'chromic phosphate'}]",
"role": "assistant"
}
] |
Physicians using this "new" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.
|
[
{
"ade": "injury to the urinary tract",
"drug": "sulfonamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Physicians using this \"new\" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.",
"role": "user"
},
{
"content": "[{'ade': 'injury to the urinary tract', 'drug': 'sulfonamide'}]",
"role": "assistant"
}
] |
We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).
|
[
{
"ade": "intracranial bleeding",
"drug": "amprenavir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).",
"role": "user"
},
{
"content": "[{'ade': 'intracranial bleeding', 'drug': 'amprenavir'}]",
"role": "assistant"
}
] |
Disseminated salmonellosis in a patient treated with temozolomide.
|
[
{
"ade": "Disseminated salmonellosis",
"drug": "temozolomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Disseminated salmonellosis in a patient treated with temozolomide.",
"role": "user"
},
{
"content": "[{'ade': 'Disseminated salmonellosis', 'drug': 'temozolomide'}]",
"role": "assistant"
}
] |
A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment.
|
[
{
"ade": "systemic lupus erythematosus",
"drug": "carbamazepine"
},
{
"ade": "SLE",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment.",
"role": "user"
},
{
"content": "[{'ade': 'systemic lupus erythematosus', 'drug': 'carbamazepine'}, {'ade': 'SLE', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.
|
[
{
"ade": "severe pain",
"drug": "naloxone"
},
{
"ade": "withdrawal syndrome",
"drug": "naloxone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.",
"role": "user"
},
{
"content": "[{'ade': 'severe pain', 'drug': 'naloxone'}, {'ade': 'withdrawal syndrome', 'drug': 'naloxone'}]",
"role": "assistant"
}
] |
RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.
|
[
{
"ade": "falling backward",
"drug": "bupropion"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.",
"role": "user"
},
{
"content": "[{'ade': 'falling backward', 'drug': 'bupropion'}]",
"role": "assistant"
}
] |
Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.
|
[
{
"ade": "RTA",
"drug": "FK506"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.",
"role": "user"
},
{
"content": "[{'ade': 'RTA', 'drug': 'FK506'}]",
"role": "assistant"
}
] |
We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.
|
[
{
"ade": "anaphylactic/anaphylactoid reaction",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylactic/anaphylactoid reaction', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Systemic corticosteroids in the phenytoin hypersensitivity syndrome.
|
[
{
"ade": "phenytoin hypersensitivity syndrome",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Systemic corticosteroids in the phenytoin hypersensitivity syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'phenytoin hypersensitivity syndrome', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.
|
[
{
"ade": "renal abnormalities",
"drug": "IFNalpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.",
"role": "user"
},
{
"content": "[{'ade': 'renal abnormalities', 'drug': 'IFNalpha'}]",
"role": "assistant"
}
] |
Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.
|
[
{
"ade": "syncope",
"drug": "oxymetazoline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.",
"role": "user"
},
{
"content": "[{'ade': 'syncope', 'drug': 'oxymetazoline'}]",
"role": "assistant"
}
] |
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.
|
[
{
"ade": "multiple myeloma",
"drug": "diphenylhydantoin"
},
{
"ade": "Monoclonal gammopathy",
"drug": "diphenylhydantoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'multiple myeloma', 'drug': 'diphenylhydantoin'}, {'ade': 'Monoclonal gammopathy', 'drug': 'diphenylhydantoin'}]",
"role": "assistant"
}
] |
One patient developed large intramural esophageal hematoma as a complication of heparin therapy.
|
[
{
"ade": "large intramural esophageal hematoma",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One patient developed large intramural esophageal hematoma as a complication of heparin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'large intramural esophageal hematoma', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide.
|
[
{
"ade": "hypoosmolality",
"drug": "lorcainide"
},
{
"ade": "hyponatremia",
"drug": "lorcainide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide.",
"role": "user"
},
{
"content": "[{'ade': 'hypoosmolality', 'drug': 'lorcainide'}, {'ade': 'hyponatremia', 'drug': 'lorcainide'}]",
"role": "assistant"
}
] |
CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.
|
[
{
"ade": "severe myelopathy",
"drug": "doxorubicin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.",
"role": "user"
},
{
"content": "[{'ade': 'severe myelopathy', 'drug': 'doxorubicin'}]",
"role": "assistant"
}
] |
Taxane-induced glaucoma.
|
[
{
"ade": "glaucoma",
"drug": "Taxane"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Taxane-induced glaucoma.",
"role": "user"
},
{
"content": "[{'ade': 'glaucoma', 'drug': 'Taxane'}]",
"role": "assistant"
}
] |
Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.
|
[
{
"ade": "Fanconi syndrome",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.",
"role": "user"
},
{
"content": "[{'ade': 'Fanconi syndrome', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
Dental and gingival pain as side effects of niacin therapy.
|
[
{
"ade": "Dental and gingival pain",
"drug": "niacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Dental and gingival pain as side effects of niacin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Dental and gingival pain', 'drug': 'niacin'}]",
"role": "assistant"
}
] |
Piritrexim-induced pulmonary toxicity.
|
[
{
"ade": "pulmonary toxicity",
"drug": "Piritrexim"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Piritrexim-induced pulmonary toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary toxicity', 'drug': 'Piritrexim'}]",
"role": "assistant"
}
] |
BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.
|
[
{
"ade": "collagenase activation",
"drug": "Colchicine"
},
{
"ade": "adverse effect on wound healing",
"drug": "Colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.",
"role": "user"
},
{
"content": "[{'ade': 'collagenase activation', 'drug': 'Colchicine'}, {'ade': 'adverse effect on wound healing', 'drug': 'Colchicine'}]",
"role": "assistant"
}
] |
Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.
|
[
{
"ade": "pancreatitis",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.",
"role": "user"
},
{
"content": "[{'ade': 'pancreatitis', 'drug': 'L-asparaginase'}]",
"role": "assistant"
}
] |
A patient presented with dilated cardiomyopathy after many years of overusing an adrenaline inhaler.
|
[
{
"ade": "dilated cardiomyopathy",
"drug": "adrenaline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient presented with dilated cardiomyopathy after many years of overusing an adrenaline inhaler.",
"role": "user"
},
{
"content": "[{'ade': 'dilated cardiomyopathy', 'drug': 'adrenaline'}]",
"role": "assistant"
}
] |
This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.
|
[
{
"ade": "sensorineural hearing loss",
"drug": "naproxen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.",
"role": "user"
},
{
"content": "[{'ade': 'sensorineural hearing loss', 'drug': 'naproxen'}]",
"role": "assistant"
}
] |
Discontinuation of the itraconazole caused resolution of the drug eruption.
|
[
{
"ade": "drug eruption",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Discontinuation of the itraconazole caused resolution of the drug eruption.",
"role": "user"
},
{
"content": "[{'ade': 'drug eruption', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.
|
[
{
"ade": "pericardial effusion",
"drug": "clozapine"
},
{
"ade": "pericarditis",
"drug": "clozapine"
},
{
"ade": "polyserositis",
"drug": "clozapine"
},
{
"ade": "pleural effusion",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.",
"role": "user"
},
{
"content": "[{'ade': 'pericardial effusion', 'drug': 'clozapine'}, {'ade': 'pericarditis', 'drug': 'clozapine'}, {'ade': 'polyserositis', 'drug': 'clozapine'}, {'ade': 'pleural effusion', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
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