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CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.	[ { "ade": "hemolytic anemia", "drug": "sulfamethoxazole" }, { "ade": "orthostatic hypotension", "drug": "trimethoprim" }, { "ade": "hepatitis", "drug": "sulfamethoxazole" }, { "ade": "aseptic meningitis", "drug": "sulfamethoxazole" }, { "ade": "hepatitis", "dru...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension...
The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.	[ { "ade": "anaphylactic reactions", "drug": "MTX" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX ...
Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.	[ { "ade": "elevation of serum transaminases", "drug": "cyanamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation o...
In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.	[ { "ade": "akathisia", "drug": "olanzapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic ...
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.	[ { "ade": "hyperglycaemic coma", "drug": "Olanzapine" }, { "ade": "neuroleptic malignant syndrome", "drug": "Olanzapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.", "role": "use...
A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.	[ { "ade": "moderately severe bronchospasm", "drug": "disodium cromoglycate" }, { "ade": "urticarial rash", "drug": "disodium cromoglycate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with d...
Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.	[ { "ade": "hypersensitivity", "drug": "sulfadiazine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.", "role": "user" }, ...
These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.	[ { "ade": "agranulocytosis", "drug": "olanzapine" }, { "ade": "leukopenia", "drug": "olanzapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose...
Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.	[ { "ade": "lupus-like syndrome", "drug": "Infliximab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.", "role": "user" }, { ...
Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.	[ { "ade": "nephropathy", "drug": "Methotrexate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that expo...
This is the first reported case of hepatolithiasis during octreotide therapy.	[ { "ade": "hepatolithiasis", "drug": "octreotide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first reported case of hepatolithiasis during octreotide therapy.", "role": "user" }, { "content": "[{'ade'...
RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.	[ { "ade": "bilateral corneal edema", "drug": "amantadine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months a...
Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.	[ { "ade": "retinopathy", "drug": "hydroxychloroquine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxy...
CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.	[ { "ade": "renal impairment", "drug": "gabapentin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, ...
Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.	[ { "ade": "Radiation recall", "drug": "gemcitabine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.", "role":...
We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.	[ { "ade": "porphyria cutanea tarda", "drug": "cyclophosphamide" }, { "ade": "porphyria cutanea tarda", "drug": "cisplatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin ...
RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.	[ { "ade": "IBD", "drug": "rofecoxib" }, { "ade": "inflammatory bowel disease", "drug": "rofecoxib" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along wi...
Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.	[ { "ade": "Syringotropic hypersensitivity reaction", "drug": "leflunomide" }, { "ade": "Syringotropic hypersensitivity reaction", "drug": "infliximab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic ar...
The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.	[ { "ade": "TEN", "drug": "phenolphthalein" }, { "ade": "rash", "drug": "phenolphthalein" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity...
METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.	[ { "ade": "contact dermatitis", "drug": "budesonide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.", "role": "user" }, {...
Cardiac arrest following use of sumatriptan.	[ { "ade": "Cardiac arrest", "drug": "sumatriptan" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cardiac arrest following use of sumatriptan.", "role": "user" }, { "content": "[{'ade': 'Cardiac arrest', 'drug': 'suma...
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).	[ { "ade": "renal failure", "drug": "HDMTX" }, { "ade": "renal failure", "drug": "methotrexate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the secon...
There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.	[ { "ade": "hyperglycemia", "drug": "olanzapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within da...
Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.	[ { "ade": "Akathisia", "drug": "clozapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misd...
Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.	[ { "ade": "Fatal complication", "drug": "formalin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.", "role": "user" ...
Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.	[ { "ade": "seizures", "drug": "imipenem" }, { "ade": "seizures", "drug": "cilastatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.", "role": "user" }, { "content": "...
Lithium-induced Creutzfeldt-Jakob syndrome.	[ { "ade": "Creutzfeldt-Jakob syndrome", "drug": "Lithium" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lithium-induced Creutzfeldt-Jakob syndrome.", "role": "user" }, { "content": "[{'ade': 'Creutzfeldt-Jakob syndrome', 'd...
Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.	[ { "ade": "dyskinesia", "drug": "amoxapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.", "role"...
The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.	[ { "ade": "lymphadenopathy", "drug": "phenytoin" }, { "ade": "rash", "drug": "phenytoin" }, { "ade": "fever", "drug": "phenytoin" }, { "ade": "hypersensitivity reactions", "drug": "phenytoin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptom...
Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.	[ { "ade": "symptoms resembling Parkinson's disease", "drug": "chlorpromazine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.", "role": "use...
We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.	[ { "ade": "Thrombotic Thrombocytopenic Purpura", "drug": "trimethoprim" }, { "ade": "Thrombotic Thrombocytopenic Purpura", "drug": "sulfamethoxazole" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy ...
We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.	[ { "ade": "pupillary mydriasis", "drug": "lidocaine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.", "role...
Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).	[ { "ade": "Extrapyramidal side effects", "drug": "sertraline" }, { "ade": "Extrapyramidal side effects", "drug": "fluoxetine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have b...
The mean time from starting MMF to the development of neutropenia was 4 months.	[ { "ade": "neutropenia", "drug": "MMF" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The mean time from starting MMF to the development of neutropenia was 4 months.", "role": "user" }, { "content": "[{'ad...
Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.	[ { "ade": "fall of the filtration fraction", "drug": "cyclosporine A" }, { "ade": "nephrotoxicity", "drug": "cyclosporine A" }, { "ade": "rise in the relative clearance of 99Tc-dimercaptosuccinic acid", "drug": "cyclosporine A" }, { "ade": "increase in proteinuria", "drug"...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the...
Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.	[ { "ade": "Alternating sinus rhythm", "drug": "propranolol" }, { "ade": "intermittent sinoatrial (S-A) block", "drug": "propranolol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina wi...
Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).	[ { "ade": "gastroenteritis", "drug": "leflunomide" }, { "ade": "abdominal sepsis", "drug": "leflunomide" }, { "ade": "infection", "drug": "leflunomide" }, { "ade": "lower respiratory tract infections", "drug": "leflunomide" }, { "ade": "cellulitis", "drug": "le...	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infection...
OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.	[ { "ade": "anaphylactoid reactions", "drug": "cisplatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.", "role": "user" }...
Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who present with fever and pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.	[ { "ade": "fever", "drug": "thalidomide" }, { "ade": "pulmonary infiltrates", "drug": "thalidomide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who prese...
Hepatitis following cimetidine administration.	[ { "ade": "Hepatitis", "drug": "cimetidine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatitis following cimetidine administration.", "role": "user" }, { "content": "[{'ade': 'Hepatitis', 'drug': 'cimetid...