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Large cerebral infarction during praziquantel therapy in neurocysticercosis.
|
[
{
"ade": "Large cerebral infarction",
"drug": "praziquantel"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Large cerebral infarction during praziquantel therapy in neurocysticercosis.",
"role": "user"
},
{
"content": "[{'ade': 'Large cerebral infarction', 'drug': 'praziquantel'}]",
"role": "assistant"
}
] |
The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.
|
[
{
"ade": "anaphylactic reaction",
"drug": "Miacalcic"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylactic reaction', 'drug': 'Miacalcic'}]",
"role": "assistant"
}
] |
Sarcoma complicating therapy with cyclophosphamide.
|
[
{
"ade": "Sarcoma",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sarcoma complicating therapy with cyclophosphamide.",
"role": "user"
},
{
"content": "[{'ade': 'Sarcoma', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.
|
[
{
"ade": "Hypersensitivity reactions",
"drug": "chloramphenicol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.",
"role": "user"
},
{
"content": "[{'ade': 'Hypersensitivity reactions', 'drug': 'chloramphenicol'}]",
"role": "assistant"
}
] |
Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.
|
[
{
"ade": "manic episodes",
"drug": "alprazolam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.",
"role": "user"
},
{
"content": "[{'ade': 'manic episodes', 'drug': 'alprazolam'}]",
"role": "assistant"
}
] |
Tardive oculogyric crisis during treatment with clozapine: report of three cases.
|
[
{
"ade": "Tardive oculogyric crisis",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tardive oculogyric crisis during treatment with clozapine: report of three cases.",
"role": "user"
},
{
"content": "[{'ade': 'Tardive oculogyric crisis', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
A case of noncardiogenic pulmonary edema by ethanolamine oleate.
|
[
{
"ade": "noncardiogenic pulmonary edema",
"drug": "ethanolamine oleate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of noncardiogenic pulmonary edema by ethanolamine oleate.",
"role": "user"
},
{
"content": "[{'ade': 'noncardiogenic pulmonary edema', 'drug': 'ethanolamine oleate'}]",
"role": "assistant"
}
] |
Clonidine-induced bradycardia in patients with spinal cord injury.
|
[
{
"ade": "bradycardia",
"drug": "Clonidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clonidine-induced bradycardia in patients with spinal cord injury.",
"role": "user"
},
{
"content": "[{'ade': 'bradycardia', 'drug': 'Clonidine'}]",
"role": "assistant"
}
] |
Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.
|
[
{
"ade": "Acute ischaemia of the leg",
"drug": "flunitrazepam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.",
"role": "user"
},
{
"content": "[{'ade': 'Acute ischaemia of the leg', 'drug': 'flunitrazepam'}]",
"role": "assistant"
}
] |
These cases demonstrate that CBZ can induce simple motor tics in children.
|
[
{
"ade": "motor tics",
"drug": "CBZ"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: These cases demonstrate that CBZ can induce simple motor tics in children.",
"role": "user"
},
{
"content": "[{'ade': 'motor tics', 'drug': 'CBZ'}]",
"role": "assistant"
}
] |
New onset of CD may be considered as an immune-mediated injury induced by etanercept.
|
[
{
"ade": "CD",
"drug": "etanercept"
},
{
"ade": "immune-mediated injury",
"drug": "etanercept"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: New onset of CD may be considered as an immune-mediated injury induced by etanercept.",
"role": "user"
},
{
"content": "[{'ade': 'CD', 'drug': 'etanercept'}, {'ade': 'immune-mediated injury', 'drug': 'etanercept'}]",
"role": "assistant"
}
] |
L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.
|
[
{
"ade": "severe necrotizing pancreatitis",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.",
"role": "user"
},
{
"content": "[{'ade': 'severe necrotizing pancreatitis', 'drug': 'L-asparaginase'}]",
"role": "assistant"
}
] |
This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.
|
[
{
"ade": "diffuse alveolar damage",
"drug": "mefloquine"
},
{
"ade": "acute lung injury",
"drug": "mefloquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.",
"role": "user"
},
{
"content": "[{'ade': 'diffuse alveolar damage', 'drug': 'mefloquine'}, {'ade': 'acute lung injury', 'drug': 'mefloquine'}]",
"role": "assistant"
}
] |
Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.
|
[
{
"ade": "Hyperpigmentation",
"drug": "interferon-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.",
"role": "user"
},
{
"content": "[{'ade': 'Hyperpigmentation', 'drug': 'interferon-alpha'}]",
"role": "assistant"
}
] |
Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.
|
[
{
"ade": "nephrotoxicity",
"drug": "Tenofovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotoxicity', 'drug': 'Tenofovir'}]",
"role": "assistant"
}
] |
Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.
|
[
{
"ade": "colonic perforation",
"drug": "sorbitol"
},
{
"ade": "colonic perforation",
"drug": "calcium polystyrene sulfonate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.",
"role": "user"
},
{
"content": "[{'ade': 'colonic perforation', 'drug': 'sorbitol'}, {'ade': 'colonic perforation', 'drug': 'calcium polystyrene sulfonate'}]",
"role": "assistant"
}
] |
Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.
|
[
{
"ade": "Colonic mucosal necrosis",
"drug": "calcium polystryrene sulfonate"
},
{
"ade": "Colonic mucosal necrosis",
"drug": "Kalimate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.",
"role": "user"
},
{
"content": "[{'ade': 'Colonic mucosal necrosis', 'drug': 'calcium polystryrene sulfonate'}, {'ade': 'Colonic mucosal necrosis', 'drug': 'Kalimate'}]",
"role": "assistant"
}
] |
After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.
|
[
{
"ade": "serum level of calcium and urinary excretion of calcium increased",
"drug": "vitamin D3"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.",
"role": "user"
},
{
"content": "[{'ade': 'serum level of calcium and urinary excretion of calcium increased', 'drug': 'vitamin D3'}]",
"role": "assistant"
}
] |
However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.
|
[
{
"ade": "acceleration of the ventricular rate",
"drug": "adenosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.",
"role": "user"
},
{
"content": "[{'ade': 'acceleration of the ventricular rate', 'drug': 'adenosine'}]",
"role": "assistant"
}
] |
Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.
|
[
{
"ade": "hepatitis",
"drug": "propylthiouracil"
},
{
"ade": "eosinophilia",
"drug": "propylthiouracil"
},
{
"ade": "skin reaction",
"drug": "propylthiouracil"
},
{
"ade": "granulocytopenia",
"drug": "propylthiouracil"
},
{
"ade": "lymphocyte sensitization",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.",
"role": "user"
},
{
"content": "[{'ade': 'hepatitis', 'drug': 'propylthiouracil'}, {'ade': 'eosinophilia', 'drug': 'propylthiouracil'}, {'ade': 'skin reaction', 'drug': 'propylthiouracil'}, {'ade': 'granulocytopenia', 'drug': 'propylthiouracil'}, {'ade': 'lymphocyte sensitization', 'drug': 'propylthiouracil'}]",
"role": "assistant"
}
] |
We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.
|
[
{
"ade": "inappropriate secretion of antidiuretic hormone",
"drug": "vinblastine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.",
"role": "user"
},
{
"content": "[{'ade': 'inappropriate secretion of antidiuretic hormone', 'drug': 'vinblastine'}]",
"role": "assistant"
}
] |
OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.
|
[
{
"ade": "lipoatrophy",
"drug": "human insulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.",
"role": "user"
},
{
"content": "[{'ade': 'lipoatrophy', 'drug': 'human insulin'}]",
"role": "assistant"
}
] |
The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.
|
[
{
"ade": "gastric mucosa foveolar hyperplasia",
"drug": "PGE1"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.",
"role": "user"
},
{
"content": "[{'ade': 'gastric mucosa foveolar hyperplasia', 'drug': 'PGE1'}]",
"role": "assistant"
}
] |
Life-threatening hyperkalemia induced by arginine.
|
[
{
"ade": "hyperkalemia",
"drug": "arginine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Life-threatening hyperkalemia induced by arginine.",
"role": "user"
},
{
"content": "[{'ade': 'hyperkalemia', 'drug': 'arginine'}]",
"role": "assistant"
}
] |
We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.
|
[
{
"ade": "endometrial cancer",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We described a very atypical case of a high stage, high grade endometrial cancer associated with tamoxifen in a 64-year-old woman with a past history of breast cancer.",
"role": "user"
},
{
"content": "[{'ade': 'endometrial cancer', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.
|
[
{
"ade": "Fatal pulmonary fibrosis",
"drug": "paclitaxel"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal pulmonary fibrosis', 'drug': 'paclitaxel'}]",
"role": "assistant"
}
] |
Ticlopidine-induced interstitial pulmonary disease: a case report.
|
[
{
"ade": "interstitial pulmonary disease",
"drug": "Ticlopidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ticlopidine-induced interstitial pulmonary disease: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial pulmonary disease', 'drug': 'Ticlopidine'}]",
"role": "assistant"
}
] |
Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.
|
[
{
"ade": "Neurologic degeneration",
"drug": "nitrous oxide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.",
"role": "user"
},
{
"content": "[{'ade': 'Neurologic degeneration', 'drug': 'nitrous oxide'}]",
"role": "assistant"
}
] |
Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.
|
[
{
"ade": "methemoglobinemia",
"drug": "Benzocaine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.",
"role": "user"
},
{
"content": "[{'ade': 'methemoglobinemia', 'drug': 'Benzocaine'}]",
"role": "assistant"
}
] |
OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.
|
[
{
"ade": "nonconvulsive status epilepticus",
"drug": "ifosfamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.",
"role": "user"
},
{
"content": "[{'ade': 'nonconvulsive status epilepticus', 'drug': 'ifosfamide'}]",
"role": "assistant"
}
] |
Physicians should be aware of the potentially lethal side effects of dapsone.
|
[
{
"ade": "lethal",
"drug": "dapsone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Physicians should be aware of the potentially lethal side effects of dapsone.",
"role": "user"
},
{
"content": "[{'ade': 'lethal', 'drug': 'dapsone'}]",
"role": "assistant"
}
] |
Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.
|
[
{
"ade": "Allergy",
"drug": "cloxacillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.",
"role": "user"
},
{
"content": "[{'ade': 'Allergy', 'drug': 'cloxacillin'}]",
"role": "assistant"
}
] |
Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.
|
[
{
"ade": "retinal toxicity",
"drug": "hydroxychloroquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.",
"role": "user"
},
{
"content": "[{'ade': 'retinal toxicity', 'drug': 'hydroxychloroquine'}]",
"role": "assistant"
}
] |
It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.
|
[
{
"ade": "thrombocytosis",
"drug": "tazobactam"
},
{
"ade": "thrombocytosis",
"drug": "piperacillin"
},
{
"ade": "thrombocytosis",
"drug": "ciprofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytosis', 'drug': 'tazobactam'}, {'ade': 'thrombocytosis', 'drug': 'piperacillin'}, {'ade': 'thrombocytosis', 'drug': 'ciprofloxacin'}]",
"role": "assistant"
}
] |
Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.
|
[
{
"ade": "agranulocytosis",
"drug": "clozapine"
},
{
"ade": "Granulocytopenia",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.",
"role": "user"
},
{
"content": "[{'ade': 'agranulocytosis', 'drug': 'clozapine'}, {'ade': 'Granulocytopenia', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).
|
[
{
"ade": "nephrotic syndrome",
"drug": "M-CSF"
},
{
"ade": "nephrotic syndrome",
"drug": "macrophage-colony-stimulating factor"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).",
"role": "user"
},
{
"content": "[{'ade': 'nephrotic syndrome', 'drug': 'M-CSF'}, {'ade': 'nephrotic syndrome', 'drug': 'macrophage-colony-stimulating factor'}]",
"role": "assistant"
}
] |
Choroidal hemorrhage associated with systemic tissue plasminogen activator.
|
[
{
"ade": "Choroidal hemorrhage",
"drug": "tissue plasminogen activator"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Choroidal hemorrhage associated with systemic tissue plasminogen activator.",
"role": "user"
},
{
"content": "[{'ade': 'Choroidal hemorrhage', 'drug': 'tissue plasminogen activator'}]",
"role": "assistant"
}
] |
Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).
|
[
{
"ade": "elevated hepatic enzymes",
"drug": "propylthiouracil"
},
{
"ade": "elevated hepatic enzymes",
"drug": "PTU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).",
"role": "user"
},
{
"content": "[{'ade': 'elevated hepatic enzymes', 'drug': 'propylthiouracil'}, {'ade': 'elevated hepatic enzymes', 'drug': 'PTU'}]",
"role": "assistant"
}
] |
We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.
|
[
{
"ade": "cough",
"drug": "quinapril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.",
"role": "user"
},
{
"content": "[{'ade': 'cough', 'drug': 'quinapril'}]",
"role": "assistant"
}
] |
Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.
|
[
{
"ade": "severe adverse reactions",
"drug": "5-fluorouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'severe adverse reactions', 'drug': '5-fluorouracil'}]",
"role": "assistant"
}
] |
In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.
|
[
{
"ade": "subacute thyroiditis",
"drug": "IFN-alpha"
},
{
"ade": "Graves' disease",
"drug": "IFN-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'subacute thyroiditis', 'drug': 'IFN-alpha'}, {'ade': \"Graves' disease\", 'drug': 'IFN-alpha'}]",
"role": "assistant"
}
] |
Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.
|
[
{
"ade": "respiratory distress",
"drug": "chlorambucil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.",
"role": "user"
},
{
"content": "[{'ade': 'respiratory distress', 'drug': 'chlorambucil'}]",
"role": "assistant"
}
] |
Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.
|
[
{
"ade": "BOOP",
"drug": "rituximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.",
"role": "user"
},
{
"content": "[{'ade': 'BOOP', 'drug': 'rituximab'}]",
"role": "assistant"
}
] |
Reversible sirolimus-associated pneumonitis after heart transplantation.
|
[
{
"ade": "pneumonitis",
"drug": "sirolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversible sirolimus-associated pneumonitis after heart transplantation.",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'sirolimus'}]",
"role": "assistant"
}
] |
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.
|
[
{
"ade": "cerebellar syndrome",
"drug": "Phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Phenytoin toxicity: an easily missed cause of cerebellar syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'cerebellar syndrome', 'drug': 'Phenytoin'}]",
"role": "assistant"
}
] |
Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.
|
[
{
"ade": "hyperthyroidism",
"drug": "IFN-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.",
"role": "user"
},
{
"content": "[{'ade': 'hyperthyroidism', 'drug': 'IFN-alpha'}]",
"role": "assistant"
}
] |
We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.
|
[
{
"ade": "Torsades de Pointes",
"drug": "garenoxacin"
},
{
"ade": "TdP",
"drug": "garenoxacin"
},
{
"ade": "ventricular tachycardia",
"drug": "garenoxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.",
"role": "user"
},
{
"content": "[{'ade': 'Torsades de Pointes', 'drug': 'garenoxacin'}, {'ade': 'TdP', 'drug': 'garenoxacin'}, {'ade': 'ventricular tachycardia', 'drug': 'garenoxacin'}]",
"role": "assistant"
}
] |
The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.
|
[
{
"ade": "leukopenia",
"drug": "AZA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.",
"role": "user"
},
{
"content": "[{'ade': 'leukopenia', 'drug': 'AZA'}]",
"role": "assistant"
}
] |
Scleritis complicating zoledronic acid infusion.
|
[
{
"ade": "Scleritis",
"drug": "zoledronic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Scleritis complicating zoledronic acid infusion.",
"role": "user"
},
{
"content": "[{'ade': 'Scleritis', 'drug': 'zoledronic acid'}]",
"role": "assistant"
}
] |
None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.
|
[
{
"ade": "cardiac arrest",
"drug": "doxorubicin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.",
"role": "user"
},
{
"content": "[{'ade': 'cardiac arrest', 'drug': 'doxorubicin'}]",
"role": "assistant"
}
] |
The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.
|
[
{
"ade": "rapidly progressive glomerulonephritis",
"drug": "D-penicillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.",
"role": "user"
},
{
"content": "[{'ade': 'rapidly progressive glomerulonephritis', 'drug': 'D-penicillamine'}]",
"role": "assistant"
}
] |
Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.
|
[
{
"ade": "eosinophilic gastroenteritis",
"drug": "gemfibrozil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.",
"role": "user"
},
{
"content": "[{'ade': 'eosinophilic gastroenteritis', 'drug': 'gemfibrozil'}]",
"role": "assistant"
}
] |
Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.
|
[
{
"ade": "vincristine neurotoxicity",
"drug": "Itraconazole"
},
{
"ade": "vincristine neurotoxicity",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.",
"role": "user"
},
{
"content": "[{'ade': 'vincristine neurotoxicity', 'drug': 'Itraconazole'}, {'ade': 'vincristine neurotoxicity', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
We report four cases of severe corneal ulceration in methamphetamine abusers.
|
[
{
"ade": "severe corneal ulceration",
"drug": "methamphetamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report four cases of severe corneal ulceration in methamphetamine abusers.",
"role": "user"
},
{
"content": "[{'ade': 'severe corneal ulceration', 'drug': 'methamphetamine'}]",
"role": "assistant"
}
] |
Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.
|
[
{
"ade": "Scleroderma-like reaction",
"drug": "uracil-tegafur"
},
{
"ade": "Scleroderma-like reaction",
"drug": "UFT"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.",
"role": "user"
},
{
"content": "[{'ade': 'Scleroderma-like reaction', 'drug': 'uracil-tegafur'}, {'ade': 'Scleroderma-like reaction', 'drug': 'UFT'}]",
"role": "assistant"
}
] |
DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.
|
[
{
"ade": "rhabdomyolysis",
"drug": "lovastatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.",
"role": "user"
},
{
"content": "[{'ade': 'rhabdomyolysis', 'drug': 'lovastatin'}]",
"role": "assistant"
}
] |
A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.
|
[
{
"ade": "fatal pancytopenia",
"drug": "levomepromazine"
},
{
"ade": "fatal pancytopenia",
"drug": "diazepam"
},
{
"ade": "fatal pancytopenia",
"drug": "lithium carbonate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.",
"role": "user"
},
{
"content": "[{'ade': 'fatal pancytopenia', 'drug': 'levomepromazine'}, {'ade': 'fatal pancytopenia', 'drug': 'diazepam'}, {'ade': 'fatal pancytopenia', 'drug': 'lithium carbonate'}]",
"role": "assistant"
}
] |
Unusual hypersensitivity to warfarin in a critically ill patient.
|
[
{
"ade": "hypersensitivity",
"drug": "warfarin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Unusual hypersensitivity to warfarin in a critically ill patient.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity', 'drug': 'warfarin'}]",
"role": "assistant"
}
] |
Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.
|
[
{
"ade": "nephropathy",
"drug": "methicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.",
"role": "user"
},
{
"content": "[{'ade': 'nephropathy', 'drug': 'methicillin'}]",
"role": "assistant"
}
] |
CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.
|
[
{
"ade": "mild cognitive impairment",
"drug": "propafenone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.",
"role": "user"
},
{
"content": "[{'ade': 'mild cognitive impairment', 'drug': 'propafenone'}]",
"role": "assistant"
}
] |
We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.
|
[
{
"ade": "seizures",
"drug": "ofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'ofloxacin'}]",
"role": "assistant"
}
] |
She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.
|
[
{
"ade": "liver failure",
"drug": "desferrioxamine"
},
{
"ade": "congestive heart failure",
"drug": "desferrioxamine"
},
{
"ade": "haemosiderosis",
"drug": "desferrioxamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.",
"role": "user"
},
{
"content": "[{'ade': 'liver failure', 'drug': 'desferrioxamine'}, {'ade': 'congestive heart failure', 'drug': 'desferrioxamine'}, {'ade': 'haemosiderosis', 'drug': 'desferrioxamine'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
|
[
{
"ade": "severe maculopathy",
"drug": "quinacrine"
},
{
"ade": "maculopathy",
"drug": "chloroquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.",
"role": "user"
},
{
"content": "[{'ade': 'severe maculopathy', 'drug': 'quinacrine'}, {'ade': 'maculopathy', 'drug': 'chloroquine'}]",
"role": "assistant"
}
] |
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).
|
[
{
"ade": "complete heart block",
"drug": "disopyramide phosphate"
},
{
"ade": "complete heart block",
"drug": "Norpace"
},
{
"ade": "CHB",
"drug": "disopyramide phosphate"
},
{
"ade": "CHB",
"drug": "Norpace"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).",
"role": "user"
},
{
"content": "[{'ade': 'complete heart block', 'drug': 'disopyramide phosphate'}, {'ade': 'complete heart block', 'drug': 'Norpace'}, {'ade': 'CHB', 'drug': 'disopyramide phosphate'}, {'ade': 'CHB', 'drug': 'Norpace'}]",
"role": "assistant"
}
] |
Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.
|
[
{
"ade": "Acute renal failure",
"drug": "immunoglobulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.",
"role": "user"
},
{
"content": "[{'ade': 'Acute renal failure', 'drug': 'immunoglobulin'}]",
"role": "assistant"
}
] |
Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.
|
[
{
"ade": "venous thromboembolism",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.",
"role": "user"
},
{
"content": "[{'ade': 'venous thromboembolism', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.
|
[
{
"ade": "increase in total Hb",
"drug": "HU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.",
"role": "user"
},
{
"content": "[{'ade': 'increase in total Hb', 'drug': 'HU'}]",
"role": "assistant"
}
] |
This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.
|
[
{
"ade": "localized purpura",
"drug": "lamotrigine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'localized purpura', 'drug': 'lamotrigine'}]",
"role": "assistant"
}
] |
Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.
|
[
{
"ade": "hypocalcaemia",
"drug": "folinic acid"
},
{
"ade": "hyperkalaemia",
"drug": "methotrexate"
},
{
"ade": "hyperphosphataemia",
"drug": "folinic acid"
},
{
"ade": "tetany",
"drug": "methotrexate"
},
{
"ade": "acute renal impairment",
"drug": "folinic acid"
},
{
"ade": "tetany",
"drug": "folinic acid"
},
{
"ade": "hyper-uricaemia",
"drug": "methotrexate"
},
{
"ade": "hyperkalaemia",
"drug": "folinic acid"
},
{
"ade": "phosphate shower syndrome",
"drug": "folinic acid"
},
{
"ade": "hyperphosphataemia",
"drug": "methotrexate"
},
{
"ade": "hyper-uricaemia",
"drug": "folinic acid"
},
{
"ade": "hypocalcaemia",
"drug": "methotrexate"
},
{
"ade": "metabolic acidosis",
"drug": "folinic acid"
},
{
"ade": "acute renal impairment",
"drug": "methotrexate"
},
{
"ade": "metabolic acidosis",
"drug": "methotrexate"
},
{
"ade": "phosphate shower syndrome",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.",
"role": "user"
},
{
"content": "[{'ade': 'hypocalcaemia', 'drug': 'folinic acid'}, {'ade': 'hyperkalaemia', 'drug': 'methotrexate'}, {'ade': 'hyperphosphataemia', 'drug': 'folinic acid'}, {'ade': 'tetany', 'drug': 'methotrexate'}, {'ade': 'acute renal impairment', 'drug': 'folinic acid'}, {'ade': 'tetany', 'drug': 'folinic acid'}, {'ade': 'hyper-uricaemia', 'drug': 'methotrexate'}, {'ade': 'hyperkalaemia', 'drug': 'folinic acid'}, {'ade': 'phosphate shower syndrome', 'drug': 'folinic acid'}, {'ade': 'hyperphosphataemia', 'drug': 'methotrexate'}, {'ade': 'hyper-uricaemia', 'drug': 'folinic acid'}, {'ade': 'hypocalcaemia', 'drug': 'methotrexate'}, {'ade': 'metabolic acidosis', 'drug': 'folinic acid'}, {'ade': 'acute renal impairment', 'drug': 'methotrexate'}, {'ade': 'metabolic acidosis', 'drug': 'methotrexate'}, {'ade': 'phosphate shower syndrome', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.
|
[
{
"ade": "acute transverse myelitis",
"drug": "hepatitis B vaccination"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.",
"role": "user"
},
{
"content": "[{'ade': 'acute transverse myelitis', 'drug': 'hepatitis B vaccination'}]",
"role": "assistant"
}
] |
The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.
|
[
{
"ade": "optic neuropathy",
"drug": "penicillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.",
"role": "user"
},
{
"content": "[{'ade': 'optic neuropathy', 'drug': 'penicillamine'}]",
"role": "assistant"
}
] |
Amoxapine-induced cognitive impairment in two patients.
|
[
{
"ade": "cognitive impairment",
"drug": "Amoxapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Amoxapine-induced cognitive impairment in two patients.",
"role": "user"
},
{
"content": "[{'ade': 'cognitive impairment', 'drug': 'Amoxapine'}]",
"role": "assistant"
}
] |
A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.
|
[
{
"ade": "hepatitis",
"drug": "halothane"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.",
"role": "user"
},
{
"content": "[{'ade': 'hepatitis', 'drug': 'halothane'}]",
"role": "assistant"
}
] |
We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.
|
[
{
"ade": "fatal pulmonary toxicity",
"drug": "erlotinib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.",
"role": "user"
},
{
"content": "[{'ade': 'fatal pulmonary toxicity', 'drug': 'erlotinib'}]",
"role": "assistant"
}
] |
There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.
|
[
{
"ade": "tics",
"drug": "atomoxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.",
"role": "user"
},
{
"content": "[{'ade': 'tics', 'drug': 'atomoxetine'}]",
"role": "assistant"
}
] |
We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.
|
[
{
"ade": "neurotoxicity",
"drug": "acyclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': 'acyclovir'}]",
"role": "assistant"
}
] |
We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.
|
[
{
"ade": "CD",
"drug": "etanercept"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.",
"role": "user"
},
{
"content": "[{'ade': 'CD', 'drug': 'etanercept'}]",
"role": "assistant"
}
] |
However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.
|
[
{
"ade": "endometrial carcinoma",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.",
"role": "user"
},
{
"content": "[{'ade': 'endometrial carcinoma', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.
|
[
{
"ade": "behavioral change",
"drug": "cinepazide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.",
"role": "user"
},
{
"content": "[{'ade': 'behavioral change', 'drug': 'cinepazide'}]",
"role": "assistant"
}
] |
The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.
|
[
{
"ade": "corneal ulcers refractory to conventional treatment",
"drug": "colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'corneal ulcers refractory to conventional treatment', 'drug': 'colchicine'}]",
"role": "assistant"
}
] |
A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.
|
[
{
"ade": "oesophageal varices",
"drug": "busulphan"
},
{
"ade": "jaundice",
"drug": "busulphan"
},
{
"ade": "ascites",
"drug": "busulphan"
},
{
"ade": "portal hypertension",
"drug": "busulphan"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.",
"role": "user"
},
{
"content": "[{'ade': 'oesophageal varices', 'drug': 'busulphan'}, {'ade': 'jaundice', 'drug': 'busulphan'}, {'ade': 'ascites', 'drug': 'busulphan'}, {'ade': 'portal hypertension', 'drug': 'busulphan'}]",
"role": "assistant"
}
] |
Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.
|
[
{
"ade": "bowel injury",
"drug": "chromic phosphate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.",
"role": "user"
},
{
"content": "[{'ade': 'bowel injury', 'drug': 'chromic phosphate'}]",
"role": "assistant"
}
] |
DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.
|
[
{
"ade": "allergy",
"drug": "AZA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.",
"role": "user"
},
{
"content": "[{'ade': 'allergy', 'drug': 'AZA'}]",
"role": "assistant"
}
] |
CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.
|
[
{
"ade": "neurotoxicity",
"drug": "INH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': 'INH'}]",
"role": "assistant"
}
] |
Acute pancreatitis after long-term 5-aminosalicylic acid therapy.
|
[
{
"ade": "Acute pancreatitis",
"drug": "5-aminosalicylic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute pancreatitis after long-term 5-aminosalicylic acid therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute pancreatitis', 'drug': '5-aminosalicylic acid'}]",
"role": "assistant"
}
] |
Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.
|
[
{
"ade": "swelling of the face and legs",
"drug": "phenytoin"
},
{
"ade": "pruritus",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.",
"role": "user"
},
{
"content": "[{'ade': 'swelling of the face and legs', 'drug': 'phenytoin'}, {'ade': 'pruritus', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.
|
[
{
"ade": "Transient anuria",
"drug": "SQ 14225"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.",
"role": "user"
},
{
"content": "[{'ade': 'Transient anuria', 'drug': 'SQ 14225'}]",
"role": "assistant"
}
] |
Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.
|
[
{
"ade": "hemorrhage",
"drug": "aspirin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.",
"role": "user"
},
{
"content": "[{'ade': 'hemorrhage', 'drug': 'aspirin'}]",
"role": "assistant"
}
] |
Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.
|
[
{
"ade": "Contact dermatitis",
"drug": "budesonide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.",
"role": "user"
},
{
"content": "[{'ade': 'Contact dermatitis', 'drug': 'budesonide'}]",
"role": "assistant"
}
] |
Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).
|
[
{
"ade": "reaction to the drug became more toxic",
"drug": "theophylline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).",
"role": "user"
},
{
"content": "[{'ade': 'reaction to the drug became more toxic', 'drug': 'theophylline'}]",
"role": "assistant"
}
] |
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.
|
[
{
"ade": "bipolar disorder",
"drug": "ritonavir"
},
{
"ade": "bipolar disorder",
"drug": "valproic Acid"
},
{
"ade": "bipolar disorder",
"drug": "lopinavir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.",
"role": "user"
},
{
"content": "[{'ade': 'bipolar disorder', 'drug': 'ritonavir'}, {'ade': 'bipolar disorder', 'drug': 'valproic Acid'}, {'ade': 'bipolar disorder', 'drug': 'lopinavir'}]",
"role": "assistant"
}
] |
In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.
|
[
{
"ade": "myopathy",
"drug": "colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.",
"role": "user"
},
{
"content": "[{'ade': 'myopathy', 'drug': 'colchicine'}]",
"role": "assistant"
}
] |
Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.
|
[
{
"ade": "cerebral infarctions",
"drug": "Thrombin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.",
"role": "user"
},
{
"content": "[{'ade': 'cerebral infarctions', 'drug': 'Thrombin'}]",
"role": "assistant"
}
] |
Acute pancreatitis is a known, although rare, complication of mesalamine treatment.
|
[
{
"ade": "Acute pancreatitis",
"drug": "mesalamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute pancreatitis is a known, although rare, complication of mesalamine treatment.",
"role": "user"
},
{
"content": "[{'ade': 'Acute pancreatitis', 'drug': 'mesalamine'}]",
"role": "assistant"
}
] |
A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.
|
[
{
"ade": "fatal interaction",
"drug": "minoxidil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.",
"role": "user"
},
{
"content": "[{'ade': 'fatal interaction', 'drug': 'minoxidil'}]",
"role": "assistant"
}
] |
Development of porphyria cutanea tarda after treatment with cyclophosphamide.
|
[
{
"ade": "porphyria cutanea tarda",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Development of porphyria cutanea tarda after treatment with cyclophosphamide.",
"role": "user"
},
{
"content": "[{'ade': 'porphyria cutanea tarda', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.
|
[
{
"ade": "severe neurotoxicity",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.",
"role": "user"
},
{
"content": "[{'ade': 'severe neurotoxicity', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.
|
[
{
"ade": "intestinal toxic effects",
"drug": "meloxicam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.",
"role": "user"
},
{
"content": "[{'ade': 'intestinal toxic effects', 'drug': 'meloxicam'}]",
"role": "assistant"
}
] |
This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.
|
[
{
"ade": "bilateral avascular necrosis of the femoral heads",
"drug": "dexamethasone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'bilateral avascular necrosis of the femoral heads', 'drug': 'dexamethasone'}]",
"role": "assistant"
}
] |
One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.
|
[
{
"ade": "feeding gastrostomy",
"drug": "risperidone"
},
{
"ade": "worsening parkinsonism",
"drug": "risperidone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.",
"role": "user"
},
{
"content": "[{'ade': 'feeding gastrostomy', 'drug': 'risperidone'}, {'ade': 'worsening parkinsonism', 'drug': 'risperidone'}]",
"role": "assistant"
}
] |
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