| toxin_id,mechanism_of_action,primary_target,molecular_target,lethal_dose_50_mouse,lethal_dose_50_human_est,exposure_route,onset_time,duration_of_effect,biomarkers,species_sensitivity,tissue_distribution,metabolism_pathway,elimination_route | |
| TX001,Inhibits acetylcholine release,Nervous system,Synaptic vesicle proteins (SNAP-25),0.00001 µg/kg (IV),0.001 µg/kg,Injection/Ingestion,Hours,Days to weeks,Acetylcholine levels,Humans > mice,Neuromuscular junctions,Proteolysis,Kidneys | |
| TX002,Blocks voltage-gated sodium channels,Nervous system,Sodium channels,8 µg/kg (IV),N/A,Ingestion,Minutes to hours,Hours,Paresthesia markers,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX003,Binds irreversibly to acetylcholine receptors,Neuromuscular junction,Nicotinic acetylcholine receptors,0.11 mg/kg (IV),N/A,Injection,Minutes to hours,Days,Acetylcholine receptor activity,Humans > mice,Neuromuscular junctions,Proteolysis,Kidneys | |
| TX004,Inhibits protein synthesis by inactivating ribosomes,Multiple organs,Ribosomes,1-20 µg/kg (IV),1-20 µg/kg,Ingestion/Inhalation,Hours,Days,Liver enzymes,Humans ≈ mice,Liver, kidneys,Proteolysis,Kidneys | |
| TX005,Forms DNA adducts, causes mutations,Liver,DNA,0.3-9 mg/kg (oral),N/A,Ingestion,Hours to days,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX006,Blocks voltage-gated sodium channels,Nervous system,Sodium channels,10 µg/kg (IP),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX007,Inhibits protein synthesis, disrupts calcium homeostasis,Kidney,Protein synthesis machinery,20-22 mg/kg (oral),N/A,Ingestion,Hours,Days,Renal function markers,Humans ≈ mice,Kidneys,Hepatic,Kidneys | |
| TX008,Inhibits RNA polymerase II,Liver, kidney,RNA polymerase II,0.1 mg/kg (IP),0.1 mg/kg,Ingestion,Hours to days,Days,Liver enzymes,Humans ≈ mice,Liver, kidneys,Hepatic,Kidneys | |
| TX009,Activates voltage-gated sodium channels,Nervous system,Sodium channels,0.45 µg/kg (IP),N/A,Ingestion,Minutes to hours,Days,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Bile | |
| TX010,Irreversibly activates sodium channels,Heart, nervous system,Sodium channels,2-3 µg/kg (SC),N/A,Injection,Minutes,Hours,Cardiac markers,Humans > mice,Heart, nervous system,Hepatic,Bile | |
| TX011,Superantigen, activates T-cells,Gastrointestinal tract, immune system,T-cell receptors,20 µg/kg (IV),N/A,Ingestion/Inhalation,Hours,Hours,Inflammatory cytokines,Humans ≈ mice,Gut, immune tissues,Proteolysis,Kidneys | |
| TX012,ADP-ribosylation of elongation factor 2,Multiple organs,Elongation factor 2,0.1 µg/kg (IV),N/A,Inhalation/Ingestion,Hours,Days,Inflammatory markers,Humans > mice,Multiple organs,Proteolysis,Kidneys | |
| TX013,Inhibits protein phosphatases 1 and 2A,Liver,Protein phosphatases,50 µg/kg (IP),N/A,Ingestion,Hours to days,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Kidneys | |
| TX014,Converts Na+/K+-ATPase into non-selective cation channel,Heart, muscle,Na+/K+-ATPase,0.15 µg/kg (IV),N/A,Injection,Minutes,Hours,Cardiac markers,Humans ≈ mice,Heart, muscle,Hepatic,Bile | |
| TX015,Inhibits protein synthesis, damages cell membranes,Multiple organs,Ribosomes, cell membranes,1.2 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX016,Inhibits protein synthesis by inactivating ribosomes,Multiple organs,Ribosomes,0.04 µg/kg (IV),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX017,Binds to glutamate receptors, causes excitotoxicity,Brain,Glutamate receptors,3.6 mg/kg (IP),N/A,Ingestion,Minutes to hours,Hours,Neurotransmitter levels,Humans ≈ mice,Brain,Hepatic,Kidneys | |
| TX018,Blocks nicotinic acetylcholine receptors,Neuromuscular junction,Nicotinic acetylcholine receptors,0.01-1.0 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Neuromuscular junctions,Proteolysis,Kidneys | |
| TX019,Blocks presynaptic acetylcholine release,Neuromuscular junction,Presynaptic terminals,2 µg/kg (IV),N/A,Injection,Minutes,Days,Acetylcholine levels,Humans > mice,Neuromuscular junctions,Proteolysis,Kidneys | |
| TX020,ADP-ribosylation of G-proteins, activates adenylate cyclase,Intestinal cells,G-proteins,250 µg/kg (oral),N/A,Ingestion,Hours,Days,Electrolyte levels,Humans ≈ mice,Intestine,Proteolysis,Kidneys | |
| TX021,Inhibits RNA polymerase II,Liver, kidney,RNA polymerase II,0.2-0.5 mg/kg (IP),0.2-0.5 mg/kg,Ingestion,Hours to days,Days,Liver enzymes,Humans ≈ mice,Liver, kidneys,Hepatic,Kidneys | |
| TX022,Disrupts bacterial cell membrane,Kidney,Cell membranes,5-20 mg/kg (IV),N/A,Injection,Hours,Hours,Renal function markers,Humans ≈ mice,Kidneys,Proteolysis,Kidneys | |
| TX023,Opens calcium channels,Heart, smooth muscle,Calcium channels,0.05 µg/kg (IP),N/A,Ingestion,Minutes,Hours,Cardiac markers,Humans ≈ mice,Heart, muscle,Hepatic,Bile | |
| TX024,Forms DNA adducts, induces mutations,Kidney, urinary tract,DNA,56-203 mg/kg (oral),N/A,Ingestion,Days,Weeks,Renal function markers,Humans ≈ mice,Kidneys,Hepatic,Kidneys | |
| TX025,Activates voltage-gated sodium channels,Nervous system,Sodium channels,0.05-0.5 mg/kg (IP),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Bile | |
| TX026,Activates PPARα, disrupts membrane function,Liver,PPARα receptors,500-1000 mg/kg (oral),N/A,Ingestion,Days,Years,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX027,Binds irreversibly to nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.2-0.25 mg/kg (IP),N/A,Ingestion,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Hepatic,Kidneys | |
| TX028,Blocks glycine receptors in spinal cord,Central nervous system,Glycine receptors,0.5-1 mg/kg (oral),0.5-1 mg/kg,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Spinal cord,Hepatic,Kidneys | |
| TX029,Inhibits protein synthesis,Multiple organs,Ribosomes,1-10 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX030,Generates reactive oxygen species,Lungs, kidneys,Oxidative stress pathways,35-50 mg/kg (oral),35-50 mg/kg,Ingestion,Hours,Days,Lung function markers,Humans ≈ mice,Lungs, kidneys,Hepatic,Kidneys | |
| TX031,Activates aryl hydrocarbon receptor,Liver, immune system,Aryl hydrocarbon receptor,0.001 mg/kg (oral),N/A,Ingestion,Days,Years,Liver enzymes,Humans ≈ mice,Liver, immune tissues,Hepatic,Bile | |
| TX032,Releases hydrogen cyanide,Multiple organs,Cytochrome c oxidase,25-30 mg/kg (oral),25-30 mg/kg,Ingestion,Minutes,Hours,Cyanide levels,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX033,Activates voltage-gated sodium channels,Heart, nervous system,Sodium channels,0.03-0.1 mg/kg (oral),0.03-0.1 mg/kg,Ingestion,Minutes,Hours,Cardiac markers,Humans > mice,Heart, nervous system,Hepatic,Kidneys | |
| TX034,Inhibits protein synthesis, induces oxidative stress,Liver, kidney,Protein synthesis machinery,2 mg/kg (IP),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver, kidneys,Hepatic,Kidneys | |
| TX035,Triggers massive neurotransmitter release,Nerve terminals,Synaptic vesicles,0.9 µg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nerve terminals,Proteolysis,Kidneys | |
| TX036,Inhibits protein phosphatases 1 and 2A,Liver,Protein phosphatases,50-70 µg/kg (IP),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Kidneys | |
| TX037,Forms pores in cell membranes,Erythrocytes, leukocytes,Cell membranes,0.03-0.07 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX038,Binds to F-actin, disrupts cytoskeleton,Liver,F-actin,2 mg/kg (IP),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Kidneys | |
| TX039,Inhibits protein phosphatases 1 and 2A,Intestine, liver,Protein phosphatases,0.2 mg/kg (IP),N/A,Ingestion,Minutes,Hours,GI distress markers,Humans ≈ mice,Intestine, liver,Hepatic,Bile | |
| TX041,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX042,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX043,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX044,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX045,Modulates sodium channels,Nervous system,Sodium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX046,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX047,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX048,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX049,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX050,Inhibits protein synthesis,Multiple organs,Ribosomes,2 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX051,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX052,Forms pores in cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX053,Prolongs sodium channel activation,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX054,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX055,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX056,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX057,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX058,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX059,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX060,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX061,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX062,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX063,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX064,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX065,Delays sodium channel inactivation,Nervous system,Sodium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX066,Induces apoptosis,Multiple organs,Apoptotic pathways,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX067,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX068,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX069,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX070,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX071,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX072,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX073,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX074,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX075,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX076,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX077, Dirac of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX078,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX079,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX080,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX081,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX082,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX083,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX084,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX085,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX086,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX087,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX088,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX089,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX090,Inhibits protein synthesis,Multiple organs,Ribosomes,0.5 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX091,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX092,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX093,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX094,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX095,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX096,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX097,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX098,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX099,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX100,Inhibits protein synthesis,Multiple organs,Ribosomes,0.5 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX101,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX102,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX103,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX104,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX105,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX106,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX107,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX108,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX109,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX110,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX111,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX112,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX113,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX114,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX115,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX116,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX117,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX118,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX119,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX120,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX121,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX122,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX123,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX124,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX125,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX126,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX127,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX128,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX129,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX130,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX131,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX132,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX133,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX134,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX135,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX136,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX137,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX138,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX139,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX140,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX141,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX142,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX143,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX144,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX145,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX146,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX147,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX148,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX149,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX150,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX151,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX152,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX153,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX154,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX155,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX156,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX157,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX158,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX159,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX160,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX161,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX162,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX163,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX164,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX165,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX166,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX167,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX168,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX169,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX170,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX171,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX172,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX173,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX174,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX175,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX176,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX177,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX178,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX179,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX180,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX181,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX182,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX183,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX184,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX185,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX186,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX187,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX188,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX189,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX190,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX191,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX192,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX193,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX194,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX195,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX196,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX197,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX198,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX199,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX200,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX201,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX202,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX203,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX204,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX205,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX206,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX207,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX208,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX209,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX210,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX211,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX212,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX213,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX214,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX215,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX216,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX217,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX218,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX219,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX220,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX221,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX222,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX223,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX224,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX225,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX226,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX227,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX228,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX229,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX230,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX231,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX232,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX233,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX234,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX235,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX236,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX237,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX238,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX239,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX240,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX241,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX242,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX243,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX244,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX245,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX246,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX247,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX248,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX249,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX250,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX251,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX252,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX253,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX254,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX255,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX256,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX257,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX258,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX259,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX260,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX261,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX262,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX263,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX264,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX265,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX266,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX267,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX268,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX269,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX270,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX271,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX272,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX273,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX274,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX275,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX276,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX277,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX278,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX279,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX280,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX281,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX282,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX283,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX284,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX285,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX286,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX287,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX288,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX289,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX290,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX291,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX292,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX293,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX294,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX295,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX296,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX297,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX298,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX299,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX300,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX301,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX302,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX303,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX304,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX305,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX306,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX307,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX308,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX309,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX310,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX311,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX312,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX313,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX314,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX315,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX316,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX317,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX318,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX319,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX320,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX321,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX322,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX323,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX324,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX325,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX326,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX327,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX328,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX329,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX330,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX331,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX332,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX333,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX334,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX335,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX336,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX337,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX338,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX339,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX340,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX341,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX342,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX343,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX344,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX345,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX346,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX347,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX348,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX349,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX350,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX351,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX352,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX353,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX354,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX355,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX356,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX357,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX358,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX359,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX360,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX361,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX362,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX363,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX364,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX365,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX366,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX367,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX368,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX369,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX370,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX371,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX372,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX373,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX374,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX375,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX376,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX377,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX378,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX379,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX380,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX381,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX382,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX383,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX384,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX385,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX386,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX387,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX388,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX389,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX390,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX391,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX392,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX393,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX394,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX395,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX396,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX397,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX398,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX399,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX400,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX401,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX402,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX403,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX404,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX405,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX406,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX407,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX408,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX409,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX410,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX411,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX412,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX413,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX414,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX415,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX416,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX417,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX418,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX419,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX420,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX421,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX422,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX423,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX424,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX425,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX426,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX427,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX428,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX429,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX430,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX431,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX432,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX433,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX434,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX435,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX436,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX437,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX438,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX439,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX440,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX441,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX442,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX443,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX444,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX445,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX446,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX447,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX448,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX449,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX450,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX451,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX452,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX453,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX454,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX455,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX456,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX457,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX458,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX459,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX460,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX461,Disrupts presynaptic membranes,Nervous system,Presynaptic membranes,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX462,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX463,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX464,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX465,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX466,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX467,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX468,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX469,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX470,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX471,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX472,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX473,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX474,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX475,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX476,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX477,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX478,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX479,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX480,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX481,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX482,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX483,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX484,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX485,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX486,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX487,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX488,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX489,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX490,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX491,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX492,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX493,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX494,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX495,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX496,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX497,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX498,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX499,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX500,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX501,Blocks nicotinic acetylcholine receptors,Nervous system,Nicotinic acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX502,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX503,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX504,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX505,Blocks calcium channels,Nervous system,Calcium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX506,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX507,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX508,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX509,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX510,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile | |
| TX511,Blocks acetylcholine receptors,Nervous system,Acetylcholine receptors,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Acetylcholine levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX512,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX513,Blocks sodium channels,Nervous system,Sodium channels,20 mg/kg (oral),N/A,Ingestion,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX514,Inhibits ceramide synthase,Liver,Ceramide synthase,15 mg/kg (oral),N/A,Ingestion,Hours,Days,Liver enzymes,Humans ≈ mice,Liver,Hepatic,Bile | |
| TX515,Blocks potassium channels,Nervous system,Potassium channels,0.05 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans > mice,Nervous system,Proteolysis,Kidneys | |
| TX516,Forms pores in cell membranes,Erythrocytes,Cell membranes,0.1 mg/kg (IV),N/A,Injection,Minutes,Hours,Hemolysis markers,Humans ≈ mice,Blood cells,Proteolysis,Kidneys | |
| TX517,Agonist of serotonin receptors,Nervous system,Serotonin receptors,0.5 mg/kg (IV),N/A,Injection,Minutes,Hours,Neurotransmitter levels,Humans ≈ mice,Nervous system,Hepatic,Kidneys | |
| TX518,Disrupts cell membranes,Multiple organs,Cell membranes,0.1 µg/kg (IV),N/A,Injection,Minutes,Hours,Inflammatory markers,Humans ≈ mice,Multiple organs,Proteolysis,Kidneys | |
| TX519,Disrupts cell membranes,Multiple organs,Cell membranes,50 mg/kg (oral),N/A,Ingestion,Hours,Hours,GI distress markers,Humans ≈ mice,Multiple organs,Hepatic,Kidneys | |
| TX520,Inhibits protein synthesis,Multiple organs,Ribosomes,1 mg/kg (oral),N/A,Ingestion,Hours,Days,Inflammatory markers,Humans ≈ mice,Multiple organs,Hepatic,Bile |