protein_name
stringlengths
4
4
structure_title
stringlengths
3
322
main_text
stringlengths
0
302k
3M2H
Crystallographic and Single Crystal Spectral Analysis of the Peroxidase Ferryl Intermediate
Crystallographic and Single Crystal Spectral Analysis of the Peroxidase Ferryl Intermediate Yergalem T. Meharenna, Tzanko Doukovb, Huiying Lia, S. Michael Soltisb,*, and Thomas L. Poulosa,* aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, Cali...
3M2I
Crystallographic and Single Crystal Spectral Analysis of the Peroxidase Ferryl Intermediate
Crystallographic and Single Crystal Spectral Analysis of the Peroxidase Ferryl Intermediate Yergalem T. Meharenna, Tzanko Doukovb, Huiying Lia, S. Michael Soltisb,*, and Thomas L. Poulosa,* aDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, Cali...
3M2K
Crystal Structure of fluorescein-labeled Class A -beta lactamase PenP in complex with cefotaxime
RESEARCH ARTICLE Open Access Structural studies of the mechanism for biosensing antibiotics in a fluorescein- labeled β-lactamase Wai-Ting Wong, Ho-Wah Au, Hong-Kin Yap, Yun-Chung Leung*, Kwok-Yin Wong* and Yanxiang Zhao* Abstract Background: β-lactamase conjugated with environment-sensitive fluorescein molecule to res...
3M2L
Crystal structure of the M113F mutant of alpha-hemolysin
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores Arijit Banerjeea, Ellina Mikhailovaa, Stephen Cheleya, Li-Qun Gub,2, Michelle Montoyac,3, Yasuo Nagaokaa,4, Eric Gouauxd, and Hagan Bayleya,1 aDepartment of Chemistry, University of Oxford, Oxford, OX1 3TA, United Kingdom; bDepartmen...
3M2R
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues,†,‡ Peder E. Cedervall§,#, Mishtu Dey||,#,⊥, Arwen R. Pearson§,⊥, Stephen W. Ragsdale||, and Carrie M. Wilmot*,||,§ § Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 554...
3M2U
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues,†,‡ Peder E. Cedervall§,#, Mishtu Dey||,#,⊥, Arwen R. Pearson§,⊥, Stephen W. Ragsdale||, and Carrie M. Wilmot*,||,§ § Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 554...
3M2V
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues,†,‡ Peder E. Cedervall§,#, Mishtu Dey||,#,⊥, Arwen R. Pearson§,⊥, Stephen W. Ragsdale||, and Carrie M. Wilmot*,||,§ § Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 554...
3M30
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues,†,‡ Peder E. Cedervall§,#, Mishtu Dey||,#,⊥, Arwen R. Pearson§,⊥, Stephen W. Ragsdale||, and Carrie M. Wilmot*,||,§ § Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 554...
3M31
Structure of the C150A/C295A mutant of S. cerevisiae Ero1p
Steps in reductive activation of the disulfide-generating enzyme Ero1p Nimrod Heldman,1 Ohad Vonshak,1 Carolyn S. Sevier,2 Elvira Vitu,1 Tevie Mehlman,3 and Deborah Fass1* 1Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel 2Department of Biology, Massachusetts Institute of Technolog...
3M32
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues
Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues,†,‡ Peder E. Cedervall§,#, Mishtu Dey||,#,⊥, Arwen R. Pearson§,⊥, Stephen W. Ragsdale||, and Carrie M. Wilmot*,||,§ § Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 554...
3M38
The roles of Glutamates and Metal ions in a rationally designed nitric oxide reductase based on myoglobin: I107E FeBMb (No metal ion binding to FeB site)
Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin Ying-Wu Lina,2, Natasha Yeunga, Yi-Gui Gaob, Kyle D. Minerc, Shiliang Tiana, Howard Robinsond, and Yi Lua,c,1 aDepartment of Chemistry, bGeorge L. Clark X-Ray Facility and 3M Materials Laboratory, andcDepartment of Bio...
3M39
The roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin: Fe(II)-I107E FeBMb (Fe(II) binding to FeB site)
Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin Ying-Wu Lina,2, Natasha Yeunga, Yi-Gui Gaob, Kyle D. Minerc, Shiliang Tiana, Howard Robinsond, and Yi Lua,c,1 aDepartment of Chemistry, bGeorge L. Clark X-Ray Facility and 3M Materials Laboratory, andcDepartment of Bio...
3M3A
The roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin: Cu(II)-I107E FeBMb (Cu(II) binding to FeB site)
Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin Ying-Wu Lina,2, Natasha Yeunga, Yi-Gui Gaob, Kyle D. Minerc, Shiliang Tiana, Howard Robinsond, and Yi Lua,c,1 aDepartment of Chemistry, bGeorge L. Clark X-Ray Facility and 3M Materials Laboratory, andcDepartment of Bio...
3M3B
The roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin: Zn(II)-I107E FeBMb (Zn(II) binding to FeB site)
Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin Ying-Wu Lina,2, Natasha Yeunga, Yi-Gui Gaob, Kyle D. Minerc, Shiliang Tiana, Howard Robinsond, and Yi Lua,c,1 aDepartment of Chemistry, bGeorge L. Clark X-Ray Facility and 3M Materials Laboratory, andcDepartment of Bio...
3M3F
PEPA bound to the ligand binding domain of GluA3 (flop form)
The molecular mechanism of flop-selectivity and subsite recognition for an AMPA receptor allosteric modulator: Structures of GluA2 and GluA3 complexed with PEPA Ahmed H. Ahmed§, Christopher P. Ptak§, and Robert E. Oswald* Department of Molecular Medicine, Cornell University, Ithaca, NY 14853 USA Abstract Glutamate rece...
3M3J
A new crystal form of Lys48-linked diubiquitin
structural communications 994 doi:10.1107/S1744309110027600 Acta Cryst. (2010). F66, 994–998 Acta Crystallographica Section F Structural Biology and Crystallization Communications ISSN 1744-3091 A new crystal form of Lys48-linked diubiquitin Jean-Franc¸ois Trempe,a* Nicholas R. Brown,b Martin E. M. Nobleb and Jane A. E...
3M3K
Ligand binding domain (S1S2) of GluA3 (flop)
The molecular mechanism of flop-selectivity and subsite recognition for an AMPA receptor allosteric modulator: Structures of GluA2 and GluA3 complexed with PEPA Ahmed H. Ahmed§, Christopher P. Ptak§, and Robert E. Oswald* Department of Molecular Medicine, Cornell University, Ithaca, NY 14853 USA Abstract Glutamate rece...
3M3L
PEPA bound to the ligand binding domain of GluA2 (flop form)
The molecular mechanism of flop-selectivity and subsite recognition for an AMPA receptor allosteric modulator: Structures of GluA2 and GluA3 complexed with PEPA Ahmed H. Ahmed§, Christopher P. Ptak§, and Robert E. Oswald* Department of Molecular Medicine, Cornell University, Ithaca, NY 14853 USA Abstract Glutamate rece...
3M3N
Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains
Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains – Implications for Actin Filament Nucleation Grzegorz Rebowski1,§, Suk Namgoong1,§, Malgorzata Boczkowska1, Paul C. Leavis2, Jorge Navaza3, and Roberto Dominguez1,* 1Department of Physiology, 3700 Hamilton Walk, University of Pennsylvania School of M...
3M3R
Crystal structure of the M113F alpha-hemolysin mutant complexed with beta-cyclodextrin
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores Arijit Banerjeea, Ellina Mikhailovaa, Stephen Cheleya, Li-Qun Gub,2, Michelle Montoyac,3, Yasuo Nagaokaa,4, Eric Gouauxd, and Hagan Bayleya,1 aDepartment of Chemistry, University of Oxford, Oxford, OX1 3TA, United Kingdom; bDepartmen...
3M3W
Crystal structure of mouse PACSIN3 BAR domain mutant
Rigidity of Wedge Loop in PACSIN 3 Protein Is a Key Factor in Dictating Diameters of Tubules*□ S Received for publication,March 4, 2012, and in revised form, April 26, 2012 Published, JBC Papers in Press,May 9, 2012, DOI 10.1074/jbc.M112.358960 Xiaoyun Bai‡§1, Geng Meng‡§1, Ming Luo¶, and Xiaofeng Zheng‡§2 From the ‡St...
3M3Y
RNA polymerase II elongation complex C
X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct Dong Wanga,b,1, Guangyu Zhuc, Xuhui Huangd, and Stephen J. Lippardc,1 aDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; bSkaggs School of Pharmacy and Pharmaceu...
3M41
Crystal structure of the mutant V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum
Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues that Stabilize the Active Conformation† B. McKay Wood‡, Tina L. Amyes§, Alexander A. Fedorov∥, Elena V. Fedorov∥, Andrew Shabila‡, Steven C. Almo∥, John P. Richard§, and John A. Gerlt*,‡ ‡Departments of Biochemistry and Chemistry, Uni...
3M43
Crystal structure of the mutant I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum
Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues that Stabilize the Active Conformation† B. McKay Wood‡, Tina L. Amyes§, Alexander A. Fedorov∥, Elena V. Fedorov∥, Andrew Shabila‡, Steven C. Almo∥, John P. Richard§, and John A. Gerlt*,‡ ‡Departments of Biochemistry and Chemistry, Uni...
3M44
Crystal structure of the mutant V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum
Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues that Stabilize the Active Conformation† B. McKay Wood‡, Tina L. Amyes§, Alexander A. Fedorov∥, Elena V. Fedorov∥, Andrew Shabila‡, Steven C. Almo∥, John P. Richard§, and John A. Gerlt*,‡ ‡Departments of Biochemistry and Chemistry, Uni...
3M45
Crystal structure of Ig1 domain of mouse SynCAM 2
N-Glycosylation at the SynCAM (Synaptic Cell Adhesion Molecule) Immunoglobulin Interface Modulates Synaptic Adhesion*□ S Received for publication,March 8, 2010, and in revised form, August 3, 2010 Published, JBC Papers in Press,August 25, 2010, DOI 10.1074/jbc.M110.120865 Adam I. Fogel‡1, Yue Li‡, Joanna Giza‡, Qing Wa...
3M47
Crystal structure of the mutant I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum
Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues that Stabilize the Active Conformation† B. McKay Wood‡, Tina L. Amyes§, Alexander A. Fedorov∥, Elena V. Fedorov∥, Andrew Shabila‡, Steven C. Almo∥, John P. Richard§, and John A. Gerlt*,‡ ‡Departments of Biochemistry and Chemistry, Uni...
3M4A
Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site
Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site Asmita Patel1, Lyudmila Yakovleva2, Stewart Shuman2,3, and Alfonso Mondragón1,3 1 Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208 ...
3M4D
Crystal structure of the M113N mutant of alpha-hemolysin
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores Arijit Banerjeea, Ellina Mikhailovaa, Stephen Cheleya, Li-Qun Gub,2, Michelle Montoyac,3, Yasuo Nagaokaa,4, Eric Gouauxd, and Hagan Bayleya,1 aDepartment of Chemistry, University of Oxford, Oxford, OX1 3TA, United Kingdom; bDepartmen...
3M4E
Crystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrin
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores Arijit Banerjeea, Ellina Mikhailovaa, Stephen Cheleya, Li-Qun Gub,2, Michelle Montoyac,3, Yasuo Nagaokaa,4, Eric Gouauxd, and Hagan Bayleya,1 aDepartment of Chemistry, University of Oxford, Oxford, OX1 3TA, United Kingdom; bDepartmen...
3M4G
H57A HFQ from Pseudomonas Aeruginosa
structural communications 760 doi:10.1107/S1744309110017331 Acta Cryst. (2010). F66, 760–764 Acta Crystallographica Section F Structural Biology and Crystallization Communications ISSN 1744-3091 The structures of mutant forms of Hfq from Pseudomonas aeruginosa reveal the importance of the conserved His57 for the protei...
3M4I
Crystal structure of the second part of the Mycobacterium tuberculosis DNA gyrase reaction core: the TOPRIM domain at 1.95 A resolution
Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase Je´re´mie Piton1,2,3, Ste´phanie Petrella4, Marc Delarue1,2, Gwe´nae¨lle Andre´-Leroux2,5, Vincent Jarlier4, Alexandra Aubry4, Claudine Mayer1,2,6* 1 Unite´ de Dynamique Structurale des Macromole´cules, De´partement de ...
3M4J
Crystal structure of N-acetyl-L-ornithine transcarbamylase complexed with PALAO
Reversible Post-Translational Carboxylation Modulates The Enzymatic Activity Of N-Acetyl-L-Ornithine Transcarbamylase† Yongdong Li1,2, Xiaolin Yu1, Jeremy Ho1, David Fushman3, Norma M. Allewell3, Mendel Tuchman1, and Dashuang Shi1,‡ 1Research Center for Genetic Medicine and Department of Integrative Systems Biology, Ch...
3M4N
Crystal structure of N-acetyl-L-ornithine transcarbamylase K302A mutant complexed with PALAO
Reversible Post-Translational Carboxylation Modulates The Enzymatic Activity Of N-Acetyl-L-Ornithine Transcarbamylase† Yongdong Li1,2, Xiaolin Yu1, Jeremy Ho1, David Fushman3, Norma M. Allewell3, Mendel Tuchman1, and Dashuang Shi1,‡ 1Research Center for Genetic Medicine and Department of Integrative Systems Biology, Ch...
3M4O
RNA polymerase II elongation complex B
X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct Dong Wanga,b,1, Guangyu Zhuc, Xuhui Huangd, and Stephen J. Lippardc,1 aDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; bSkaggs School of Pharmacy and Pharmaceu...
3M4U
Crystal Structure of Trypanosoma brucei Protein Tyrosine Phosphatase TbPTP1
The Trypanosoma brucei Life Cycle Switch TbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46* Received for publication,January 28, 2010, and in revised form, April 19, 2010 Published, JBC Papers in Press,May 5, 2010, DOI 10.1074/jbc.M110.108860 Seemay Chou‡, Bryan C. Jensen§, Marilyn P...
3M4W
Structural basis for the negative regulation of bacterial stress response by RseB
PROTEIN STRUCTURE REPORT Structural basis for the negative regulation of bacterial stress response by RseB Dong Young Kim, Eunju Kwon, JongKeun Choi, Hye-Yeon Hwang, and Kyeong Kyu Kim* Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea Received 29 December 2009; Revi...
3M53
SET7/9 in complex with TAF10 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M54
SET7/9 Y305F in complex with TAF10 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M55
SET7/9 Y305F in complex with TAF10-K189me1 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M56
SET7/9 Y305F in complex with TAF10-K189me2 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M57
SET7/9 Y245A in complex with TAF10 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M58
SET7/9 Y245A in complex with TAF10-K189me1 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M59
SET7/9 Y245A in complex with TAF10-K189me2 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M5A
SET7/9 Y245A in complex with TAF10-K189me3 peptide and AdoHcy
SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation*□ S Received for publication,February 15, 2010, and in revised form, July 14, 2010 Published, JBC Papers in Press,August 1, 2010, DOI 10.1074/jbc.M110.114587 Paul A. Del Rizzo‡, Jean-Franc¸ois Couture‡§1, Lynnette M. ...
3M5C
Crystal structure of N-acetyl-L-ornithine transcarbamylase K302E mutant complexed with PALAO
Reversible Post-Translational Carboxylation Modulates The Enzymatic Activity Of N-Acetyl-L-Ornithine Transcarbamylase† Yongdong Li1,2, Xiaolin Yu1, Jeremy Ho1, David Fushman3, Norma M. Allewell3, Mendel Tuchman1, and Dashuang Shi1,‡ 1Research Center for Genetic Medicine and Department of Integrative Systems Biology, Ch...
3M5D
Crystal structure of N-acetyl-L-ornithine transcarbamylase K302R mutant complexed with PALAO
Reversible Post-Translational Carboxylation Modulates The Enzymatic Activity Of N-Acetyl-L-Ornithine Transcarbamylase† Yongdong Li1,2, Xiaolin Yu1, Jeremy Ho1, David Fushman3, Norma M. Allewell3, Mendel Tuchman1, and Dashuang Shi1,‡ 1Research Center for Genetic Medicine and Department of Integrative Systems Biology, Ch...
3M5G
Crystal structure of a H7 influenza virus hemagglutinin
Structures of Receptor Complexes of a North American H7N2 Influenza Hemagglutinin with a Loop Deletion in the Receptor Binding Site Hua Yang, Li-Mei Chen, Paul J. Carney, Ruben O. Donis, James Stevens* Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Abstract Hu...
3M5H
Crystal structure of a H7 influenza virus hemagglutinin complexed with 3SLN
Structures of Receptor Complexes of a North American H7N2 Influenza Hemagglutinin with a Loop Deletion in the Receptor Binding Site Hua Yang, Li-Mei Chen, Paul J. Carney, Ruben O. Donis, James Stevens* Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Abstract Hu...
3M5I
Crystal structure of a H7 influenza virus hemagglutinin complexed with 6SLN
Structures of Receptor Complexes of a North American H7N2 Influenza Hemagglutinin with a Loop Deletion in the Receptor Binding Site Hua Yang, Li-Mei Chen, Paul J. Carney, Ruben O. Donis, James Stevens* Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Abstract Hu...
3M5J
Crystal structure of a H7 influenza virus hemagglutinin complexed with LSTb
Structures of Receptor Complexes of a North American H7N2 Influenza Hemagglutinin with a Loop Deletion in the Receptor Binding Site Hua Yang, Li-Mei Chen, Paul J. Carney, Ruben O. Donis, James Stevens* Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Abstract Hu...
3M5L
Crystal structure of HCV NS3/4A protease in complex with ITMN-191
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding Keith P. Romano1, Akbar Ali1, William E. Royer, and Celia A. Schiffer2 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Edited b...
3M5M
Avoiding drug resistance against HCV NS3/4A protease inhibitors
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding Keith P. Romano1, Akbar Ali1, William E. Royer, and Celia A. Schiffer2 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Edited b...
3M5N
Crystal structure of HCV NS3/4A protease in complex with N-terminal product 4B5A
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding Keith P. Romano1, Akbar Ali1, William E. Royer, and Celia A. Schiffer2 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Edited b...
3M5O
Crystal structure of HCV NS3/4A protease in complex with N-terminal product 5A5B
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding Keith P. Romano1, Akbar Ali1, William E. Royer, and Celia A. Schiffer2 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 Edited b...
3M5Q
0.93 A Structure of Manganese-Bound Manganese Peroxidase
Ultrahigh (0.93 Å) Resolution Structure of Manganese Peroxidase from Phanerochaete chrysosporium: Implications for the Catalytic Mechanism†,£ Munirathinam Sundaramoorthy‡,*, Michael H. Gold∥, and Thomas L. Poulos⊥ ‡ Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232 ∥ Department of Bi...
3M5X
Crystal structure of the mutant V182A,I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum
Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues that Stabilize the Active Conformation† B. McKay Wood‡, Tina L. Amyes§, Alexander A. Fedorov∥, Elena V. Fedorov∥, Andrew Shabila‡, Steven C. Almo∥, John P. Richard§, and John A. Gerlt*,‡ ‡Departments of Biochemistry and Chemistry, Uni...
3M5Y
Crystal structure of the mutant V182A,V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum
Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues that Stabilize the Active Conformation† B. McKay Wood‡, Tina L. Amyes§, Alexander A. Fedorov∥, Elena V. Fedorov∥, Andrew Shabila‡, Steven C. Almo∥, John P. Richard§, and John A. Gerlt*,‡ ‡Departments of Biochemistry and Chemistry, Uni...
3M5Z
Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum
Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues that Stabilize the Active Conformation† B. McKay Wood‡, Tina L. Amyes§, Alexander A. Fedorov∥, Elena V. Fedorov∥, Andrew Shabila‡, Steven C. Almo∥, John P. Richard§, and John A. Gerlt*,‡ ‡Departments of Biochemistry and Chemistry, Uni...
3M62
Crystal structure of Ufd2 in complex with the ubiquitin-like (UBL) domain of Rad23
The Yeast E4 Ubiquitin Ligase Ufd2 Interacts with the Ubiquitin-like Domains of Rad23 and Dsk2 via a Novel and Distinct Ubiquitin-like Binding Domain*□ S Received for publication,February 12, 2010, and in revised form, March 22, 2010 Published, JBC Papers in Press,April 28, 2010, DOI 10.1074/jbc.M110.112532 Petra Ha¨nz...
3M63
Crystal structure of Ufd2 in complex with the ubiquitin-like (UBL) domain of Dsk2
The Yeast E4 Ubiquitin Ligase Ufd2 Interacts with the Ubiquitin-like Domains of Rad23 and Dsk2 via a Novel and Distinct Ubiquitin-like Binding Domain*□ S Received for publication,February 12, 2010, and in revised form, March 22, 2010 Published, JBC Papers in Press,April 28, 2010, DOI 10.1074/jbc.M110.112532 Petra Ha¨nz...
3M6B
Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase
Biochemical and Structural Characterization of Mycobacterium tuberculosis β-Lactamase (BlaC) with the Carbapenems Ertapenem and Doripenem Lee W. Tremblay#, Fan Fan#, and John S Blanchard‡,* Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461 Abstract Despite t...
3M6C
Crystal structure of Mycobacterium tuberculosis GroEL1 apical domain
Structural and Functional Conservation of Mycobacterium tuberculosis GroEL Paralogs Suggests that GroEL1 is a Chaperonin Bernhard Sielaff*, Ki Seog Lee*,2, and Francis T.F. Tsai1 Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and Department of Molecular and Cellular Biology, Baylor College of ...
3M6H
Crystal Structure of Post-isomerized Ertapenem Covalent Adduct with TB B-lactamase
Biochemical and Structural Characterization of Mycobacterium tuberculosis β-Lactamase (BlaC) with the Carbapenems Ertapenem and Doripenem Lee W. Tremblay#, Fan Fan#, and John S Blanchard‡,* Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461 Abstract Despite t...
3M6K
Crystal Structure of N-terminal 44 kDa fragment of topoisomerase V in the presence of guanidium hydrochloride
Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding Rakhi Rajan*, Bhupesh Taneja*,†, and Alfonso Mondragón*,‡ * Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Dr, Evanston, IL 60208 Summary Topoisomerase...
3M6O
Crystal structure of Arabidopsis thaliana peptide deformylase 1B (AtPDF1B)
Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis Sonia Fieulaine1, Adrien Boularot1, Isabelle Artaud2,3, Michel Desmadril4,5, Fre´de´ric Dardel6,7, Thierry Meinnel1*, Carmela Giglione1* 1 CNRS, ISV, UPR2355, Gif-sur-Yvette, France, 2 Univ...
3M6P
Crystal structure of Arabidopsis thaliana peptide deformylase 1B (AtPDF1B) in complex with actinonin
Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis Sonia Fieulaine1, Adrien Boularot1, Isabelle Artaud2,3, Michel Desmadril4,5, Fre´de´ric Dardel6,7, Thierry Meinnel1*, Carmela Giglione1* 1 CNRS, ISV, UPR2355, Gif-sur-Yvette, France, 2 Univ...
3M6Q
Crystal structure of Arabidopsis thaliana peptide deformylase 1B (AtPDF1B) G41Q mutant in complex with actinonin
Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis Sonia Fieulaine1, Adrien Boularot1, Isabelle Artaud2,3, Michel Desmadril4,5, Fre´de´ric Dardel6,7, Thierry Meinnel1*, Carmela Giglione1* 1 CNRS, ISV, UPR2355, Gif-sur-Yvette, France, 2 Univ...
3M6R
Crystal structure of Arabidopsis thaliana peptide deformylase 1B (AtPDF1B) G41M mutant in complex with actinonin
Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis Sonia Fieulaine1, Adrien Boularot1, Isabelle Artaud2,3, Michel Desmadril4,5, Fre´de´ric Dardel6,7, Thierry Meinnel1*, Carmela Giglione1* 1 CNRS, ISV, UPR2355, Gif-sur-Yvette, France, 2 Univ...
3M6U
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group 43
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus HASAN DEMIRCI,1,3 LINE H.G. LARSEN,2,3 TRINE HANSEN,2 ANETTE RASMUSSEN,2 ASHWIN CADAMBI,1 STEVEN T. GREGORY,1 FINN KIRPEKAR,2 and GERWALD JOGL1 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rho...
3M6V
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P2 in complex with S-Adenosyl-L-Methionine
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus HASAN DEMIRCI,1,3 LINE H.G. LARSEN,2,3 TRINE HANSEN,2 ANETTE RASMUSSEN,2 ASHWIN CADAMBI,1 STEVEN T. GREGORY,1 FINN KIRPEKAR,2 and GERWALD JOGL1 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rho...
3M6W
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P21212 in complex with S-Adenosyl-L-Methionine
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus HASAN DEMIRCI,1,3 LINE H.G. LARSEN,2,3 TRINE HANSEN,2 ANETTE RASMUSSEN,2 ASHWIN CADAMBI,1 STEVEN T. GREGORY,1 FINN KIRPEKAR,2 and GERWALD JOGL1 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rho...
3M6X
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P21212
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus HASAN DEMIRCI,1,3 LINE H.G. LARSEN,2,3 TRINE HANSEN,2 ANETTE RASMUSSEN,2 ASHWIN CADAMBI,1 STEVEN T. GREGORY,1 FINN KIRPEKAR,2 and GERWALD JOGL1 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rho...
3M6Z
Crystal structure of an N-terminal 44 kDa fragment of topoisomerase V in the presence of guanidium hydrochloride
Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding Rakhi Rajan*, Bhupesh Taneja*,†, and Alfonso Mondragón*,‡ * Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Dr, Evanston, IL 60208 Summary Topoisomerase...
3M71
Crystal Structure of Plant SLAC1 homolog TehA
Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves Yuhang Chen1,6, Lei Hu2, Marco Punta6,7, Renato Bruni6, Brandan Hillerich6, Brian Kloss6, Burkhard Rost1,6,1, James Love6, Steven A. Siegelbaum2,3,5, and Wayne A. Hendrickson1,4,5,6 1Department of Biochemistry and Molecular Biophysics, Columb...
3M73
Crystal Structure of Plant SLAC1 homolog TehA
Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves Yuhang Chen1,6, Lei Hu2, Marco Punta6,7, Renato Bruni6, Brandan Hillerich6, Brian Kloss6, Burkhard Rost1,6,1, James Love6, Steven A. Siegelbaum2,3,5, and Wayne A. Hendrickson1,4,5,6 1Department of Biochemistry and Molecular Biophysics, Columb...
3M74
Crystal Structure of Plant SLAC1 homolog TehA
Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves Yuhang Chen1,6, Lei Hu2, Marco Punta6,7, Renato Bruni6, Brandan Hillerich6, Brian Kloss6, Burkhard Rost1,6,1, James Love6, Steven A. Siegelbaum2,3,5, and Wayne A. Hendrickson1,4,5,6 1Department of Biochemistry and Molecular Biophysics, Columb...
3M75
Crystal Structure of Plant SLAC1 homolog TehA
Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves Yuhang Chen1,6, Lei Hu2, Marco Punta6,7, Renato Bruni6, Brandan Hillerich6, Brian Kloss6, Burkhard Rost1,6,1, James Love6, Steven A. Siegelbaum2,3,5, and Wayne A. Hendrickson1,4,5,6 1Department of Biochemistry and Molecular Biophysics, Columb...
3M76
Crystal Structure of Plant SLAC1 homolog TehA
Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves Yuhang Chen1,6, Lei Hu2, Marco Punta6,7, Renato Bruni6, Brandan Hillerich6, Brian Kloss6, Burkhard Rost1,6,1, James Love6, Steven A. Siegelbaum2,3,5, and Wayne A. Hendrickson1,4,5,6 1Department of Biochemistry and Molecular Biophysics, Columb...
3M79
A tetrameric Zn-bound cytochrome cb562 complex with covalently and non-covalently stabilized interfaces crystallized in the presence of Cu(II) and Zn(II)
Evolution of Metal Selectivity in Templated Protein Interfaces Jeffrey D. Brodin†, Annette Medina-Morales†, Thomas Ni†, Eric N. Salgado†, Xavier I. Ambroggio‡, and F. Akif Tezcan†,* † Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0356 ‡ Rosetta Design Group LLC, Fairf...
3M7D
Crystal structure of an N-terminal 44 kDA fragment of topoisomerase V in the presence of dioxane
Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding Rakhi Rajan*, Bhupesh Taneja*,†, and Alfonso Mondragón*,‡ * Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Dr, Evanston, IL 60208 Summary Topoisomerase...
3M7F
Crystal structure of the Nedd4 C2/Grb10 SH2 complex
Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4* Received for publication,May 10, 2010, and in revised form, October 11, 2010 Published, JBC Papers in Press,October 26, 2010, DOI 10.1074/jbc.M110.143412 Qingqiu Huang1 and Doletha M. E. Szebenyi From...
3M7G
Structure of topoisomerase domain of topoisomerase V protein
Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding Rakhi Rajan*, Bhupesh Taneja*,†, and Alfonso Mondragón*,‡ * Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Dr, Evanston, IL 60208 Summary Topoisomerase...
3M7H
Crystal structure of the bacteriocin LLPA from Pseudomonas sp.
Structural Determinants for Activity and Specificity of the Bacterial Toxin LlpA Maarten G. K. Ghequire1., Abel Garcia-Pino2,3., Eline K. M. Lebbe1¤, Stijn Spaepen1, Remy Loris"2,3*, Rene´ De Mot"1* 1 Centre of Microbial and Plant Genetics, University of Leuven, Heverlee-Leuven, Belgium, 2 Molecular Recognition Unit, D...
3M7J
Crystal structure of the bacteriocin LLPA from pseudomonas sp. in complex with Met-mannose
Structural Determinants for Activity and Specificity of the Bacterial Toxin LlpA Maarten G. K. Ghequire1., Abel Garcia-Pino2,3., Eline K. M. Lebbe1¤, Stijn Spaepen1, Remy Loris"2,3*, Rene´ De Mot"1* 1 Centre of Microbial and Plant Genetics, University of Leuven, Heverlee-Leuven, Belgium, 2 Molecular Recognition Unit, D...
3M7K
Crystal structure of PacI-DNA Enzyme product complex
Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI Betty Shen1, Daniel F. Heiter2, Siu-Hong Chan2, Hua Wang2, Shuang-Yong Xu2, Richard D. Morgan2, Geoffrey G. Wilson2, and Barry L. Stoddard1,3 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N. A3...
3M7L
Crystal Structure of Plant SLAC1 homolog TehA
Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves Yuhang Chen1,6, Lei Hu2, Marco Punta6,7, Renato Bruni6, Brandan Hillerich6, Brian Kloss6, Burkhard Rost1,6,1, James Love6, Steven A. Siegelbaum2,3,5, and Wayne A. Hendrickson1,4,5,6 1Department of Biochemistry and Molecular Biophysics, Columb...
3M7N
archaeoglobus fulgidus exosome with RNA bound to the active site
Quantitative analysis of processive RNA degradation by the archaeal RNA exosome Sophia Hartung1, Theresa Niederberger1, Marianne Hartung2, Achim Tresch1 and Karl-Peter Hopfner1,* 1Center for Integrated Protein Sciences and Munich Center for Advanced Photonics at the Gene Center, Department of Biochemistry, Ludwig-Maxim...
3M7W
Crystal Structure of Type I 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 in Covalent Complex with Dehydroquinate
Insights into the Mechanism of Type I Dehydroquinate Dehydratases from Structures of Reaction Intermediates* Received for publication,October 8, 2010, and in revised form, October 28, 2010 Published, JBC Papers in Press,November 18, 2010, DOI 10.1074/jbc.M110.192831 Samuel H. Light‡§, George Minasov‡§, Ludmilla Shuvalo...
3M81
Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.50 A resolution (native apo structure)
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima Mark Levisson1,*, Gye Won Han2,3,*, Marc C. Deller2,3, Qingping Xu2,4, Peter Biely5, Sjon Hendriks1, Lynn F. Ten Eyck6,7, Claus Flensburg8, Pietro Roversi8, Mitchell D. Miller2,4, Daniel McMullan9, Frank von Delft2,3,‡...
3M82
Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.40 A resolution (PMSF inhibitor complex structure)
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima Mark Levisson1,*, Gye Won Han2,3,*, Marc C. Deller2,3, Qingping Xu2,4, Peter Biely5, Sjon Hendriks1, Lynn F. Ten Eyck6,7, Claus Flensburg8, Pietro Roversi8, Mitchell D. Miller2,4, Daniel McMullan9, Frank von Delft2,3,‡...
3M83
Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.12 A resolution (paraoxon inhibitor complex structure)
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima Mark Levisson1,*, Gye Won Han2,3,*, Marc C. Deller2,3, Qingping Xu2,4, Peter Biely5, Sjon Hendriks1, Lynn F. Ten Eyck6,7, Claus Flensburg8, Pietro Roversi8, Mitchell D. Miller2,4, Daniel McMullan9, Frank von Delft2,3,‡...
3M85
Archaeoglobus fulgidus exosome y70a with RNA bound to the active site
Quantitative analysis of processive RNA degradation by the archaeal RNA exosome Sophia Hartung1, Theresa Niederberger1, Marianne Hartung2, Achim Tresch1 and Karl-Peter Hopfner1,* 1Center for Integrated Protein Sciences and Munich Center for Advanced Photonics at the Gene Center, Department of Biochemistry, Ludwig-Maxim...
3M89
Structure of TubZ-GTP-g-S
Plasmid protein TubR uses a distinct mode of HTH- DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition Lisheng Ni, Weijun Xu, Muthiah Kumaraswami, and Maria A. Schumacher1 Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Unit 1000, Hou...
3M8B
Crystal structure of spin-labeled BtuB V10R1 in the apo state
Conformational Exchange in a Membrane Transport Protein Is Altered in Protein Crystals Daniel M. Freed,† Peter S. Horanyi,‡ Michael C. Wiener,‡ and David S. Cafiso†‡* †Departments of Chemistry and ‡Molecular Physiology and Biological Physics, and the Biophysics Program, University of Virginia, Charlottesville, Virginia ...
3M8D
Crystal structure of spin-labeled BtuB V10R1 with bound calcium and cyanocobalamin
Conformational Exchange in a Membrane Transport Protein Is Altered in Protein Crystals Daniel M. Freed,† Peter S. Horanyi,‡ Michael C. Wiener,‡ and David S. Cafiso†‡* †Departments of Chemistry and ‡Molecular Physiology and Biological Physics, and the Biophysics Program, University of Virginia, Charlottesville, Virginia ...
3M8E
Protein structure of Type III plasmid segregation TubR
Plasmid protein TubR uses a distinct mode of HTH- DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition Lisheng Ni, Weijun Xu, Muthiah Kumaraswami, and Maria A. Schumacher1 Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Unit 1000, Hou...
3M8F
Protein structure of type III plasmid segregation TubR mutant
Plasmid protein TubR uses a distinct mode of HTH- DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition Lisheng Ni, Weijun Xu, Muthiah Kumaraswami, and Maria A. Schumacher1 Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Unit 1000, Hou...
3M8K
Protein structure of type III plasmid segregation TubZ
Plasmid protein TubR uses a distinct mode of HTH- DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition Lisheng Ni, Weijun Xu, Muthiah Kumaraswami, and Maria A. Schumacher1 Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Unit 1000, Hou...
3M8L
Crystal Structure Analysis of the Feline Calicivirus Capsid Protein
JOURNAL OF VIROLOGY, June 2010, p. 5550–5564 Vol. 84, No. 11 0022-538X/10/$12.00 doi:10.1128/JVI.02371-09 Copyright © 2010, American Society for Microbiology. All Rights Reserved. Conformational Changes in the Capsid of a Calicivirus upon Interaction with Its Functional Receptor Robert J. Ossiboff,1† Yi Zhou,2† Patric...