source,target,relation,potency_nM
SNCA,alpha-synuclein aggregation and propagation,belongs_to_pathway,
SNCA,SNCA triplication/A53T iPSC dopaminergic neurons or alpha-synuclein PFF model,validated_in_model,
SNCA,CHEMBL3593932,has_refined_activity,2.1
SNCA,CHEMBL2063787,has_refined_activity,32.1
SNCA,CHEMBL3593904,has_refined_activity,11.5
SNCA,CHEMBL3593922,has_refined_activity,14.6
SNCA,CHEMBL3593930,has_refined_activity,3.5
SNCA,CHEMBL3593928,has_refined_activity,3.8
SNCA,CHEMBL3593911,has_refined_activity,4.2
SNCA,CHEMBL1976750,has_refined_activity,116.5
SNCA,CHEMBL3593934,has_refined_activity,8.9
SNCA,CHEMBL2063785,has_refined_activity,121.8
SNCA,CHEMBL3593903,has_refined_activity,40.7
SNCA,CHEMBL3593918,has_refined_activity,44.8
SNCA,CHEMBL3593926,has_refined_activity,12.9
SNCA,CHEMBL3593905,has_refined_activity,54.0
SNCA,CHEMBL3593902,has_refined_activity,61.1
SNCA,CHEMBL3593908,has_refined_activity,63.7
SNCA,CHEMBL3593924,has_refined_activity,25.0
SNCA,CHEMBL3593893,has_refined_activity,124.3
SNCA,CHEMBL3593915,has_refined_activity,29.8
SNCA,CHEMBL3593909,has_refined_activity,40.9
SNCA,CHEMBL3593916,has_refined_activity,43.6
SNCA,CHEMBL3593913,has_refined_activity,45.3
SNCA,CHEMBL2063797,has_refined_activity,49.0
SNCA,CHEMBL3593901,has_refined_activity,206.7
SNCA,CHEMBL3593923,has_refined_activity,211.4
SNCA,CHEMBL3593931,has_refined_activity,53.3
SNCA,CHEMBL3593910,has_refined_activity,54.6
SNCA,CHEMBL2063798,has_refined_activity,57.9
SNCA triplication/A53T iPSC dopaminergic neurons or alpha-synuclein PFF model,"pS129 alpha-synuclein, aggregate load, synaptic/neurite phenotypes",measured_by,
GLP1R,metabolic and GLP-1 receptor signalling,belongs_to_pathway,
GLP1R,dopaminergic neuron stress model with metabolic/inflammatory co-culture,validated_in_model,
GLP1R,CHEMBL398714,has_refined_activity,32.0
GLP1R,CHEMBL250091,has_refined_activity,91.0
GLP1R,CHEMBL249091,has_refined_activity,107.0
GLP1R,CHEMBL402918,has_refined_activity,109.0
GLP1R,CHEMBL399713,has_refined_activity,175.0
GLP1R,CHEMBL250747,has_refined_activity,253.0
dopaminergic neuron stress model with metabolic/inflammatory co-culture,"neuronal survival, inflammatory cytokines, mitochondrial respiration",measured_by,
LRRK2,LRRK2 kinase and lysosomal stress,belongs_to_pathway,
LRRK2,LRRK2 G2019S or R1441C iPSC-derived dopaminergic neurons,validated_in_model,
LRRK2,NINTEDANIB,has_refined_activity,37.0
LRRK2 G2019S or R1441C iPSC-derived dopaminergic neurons,"phospho-Rab10/Rab12, lysosomal morphology, neurite survival",measured_by,
GBA1,GBA1 lysosome/autophagy,belongs_to_pathway,
GBA1,GBA1-mutant iPSC dopaminergic neurons and macrophage/microglia-like cells,validated_in_model,
GBA1,CHEMBL3349996,has_refined_activity,2.4
GBA1-mutant iPSC dopaminergic neurons and macrophage/microglia-like cells,"glucocerebrosidase activity, lysosomal pH, alpha-synuclein burden",measured_by,
MAPK1,MAP kinase activation,belongs_to_pathway,
MAPK1,stress-response assay in neurons and microglia,validated_in_model,
stress-response assay in neurons and microglia,"phospho-ERK, inflammatory/stress response, toxicity counterscreen",measured_by,
NOD2,NOD1/2 inflammatory signalling,belongs_to_pathway,
NOD2,iPSC-derived microglia or monocyte-derived macrophages,validated_in_model,
iPSC-derived microglia or monocyte-derived macrophages,"NOD ligand response, cytokines, inflammasome-related markers",measured_by,
IL17A,IL-17 inflammatory signalling,belongs_to_pathway,
IL17A,microglia/astrocyte inflammatory co-culture,validated_in_model,
IL17A,CHEMBL4872143,has_refined_activity,2.0
microglia/astrocyte inflammatory co-culture,"IL-17 response genes, cytokine release, neuronal stress markers",measured_by,
TLR2,innate immune signalling,belongs_to_pathway,
TLR2,iPSC-derived microglia and neuron-microglia co-culture,validated_in_model,
innate immune signalling,MYD88,belongs_to_pathway,
iPSC-derived microglia and neuron-microglia co-culture,"TNF/IL6/IL1B release, NF-kB activation, neuronal toxicity",measured_by,
NTRK1,NTRK/neurotrophin signalling,belongs_to_pathway,
NTRK1,dopaminergic neuron survival/trophic support model,validated_in_model,
NTRK1,CHEMBL211168,has_refined_activity,1.0
NTRK1,CHEMBL211095,has_refined_activity,1.0
NTRK1,GW278681X,has_refined_activity,6.0
NTRK1,CHEMBL175321,has_refined_activity,6.0
NTRK1,GW301789X,has_refined_activity,8.0
NTRK1,CHEMBL172179,has_refined_activity,12.0
NTRK1,GW284408X,has_refined_activity,7.0
NTRK1,CHEMBL211883,has_refined_activity,8.0
NTRK1,CHEMBL2113063,has_refined_activity,3.0
NTRK1,CHEMBL445660,has_refined_activity,10.0
NTRK1,CHEMBL208881,has_refined_activity,19.0
NTRK1,CHEMBL2113064,has_refined_activity,2.9
NTRK1,CHEMBL377243,has_refined_activity,28.0
NTRK1,CHEMBL212317,has_refined_activity,29.0
NTRK1,GW442130X,has_refined_activity,8.0
NTRK1,CHEMBL2113062,has_refined_activity,20.0
NTRK1,CHEMBL94678,has_refined_activity,1.2
NTRK1,CHEMBL176544,has_refined_activity,2.0
NTRK1,CHEMBL377040,has_refined_activity,45.0
NTRK1,CHEMBL377444,has_refined_activity,47.0
NTRK1,CHEMBL369490,has_refined_activity,61.0
NTRK1,GW275616X,has_refined_activity,63.0
dopaminergic neuron survival/trophic support model,"neurite length, survival, phospho-ERK/AKT",measured_by,
SLC6A3,dopaminergic synapse,belongs_to_pathway,
SLC6A3,iPSC dopaminergic neuron maturation/readout assay,validated_in_model,
SLC6A3,CHEMBL353333,has_refined_activity,0.12
SLC6A3,CHEMBL173427,has_refined_activity,1.88
SLC6A3,CHEMBL27586,has_refined_activity,9.2
SLC6A3,CHEMBL174088,has_refined_activity,3.47
SLC6A3,CHEMBL28394,has_refined_activity,0.22
SLC6A3,CHEMBL281288,has_refined_activity,1.2
SLC6A3,CHEMBL27336,has_refined_activity,2.6
SLC6A3,CHEMBL311347,has_refined_activity,0.48
SLC6A3,FLUVOXAMINE,has_refined_activity,1.46
SLC6A3,VILOXAZINE,has_refined_activity,155.0
SLC6A3,CHEMBL173594,has_refined_activity,28.0
SLC6A3,CHEMBL610897,has_refined_activity,1.7
SLC6A3,CHEMBL435341,has_refined_activity,32.0
SLC6A3,CHEMBL2115570,has_refined_activity,16.0
SLC6A3,DESIPRAMINE,has_refined_activity,0.49
SLC6A3,CHEMBL285342,has_refined_activity,125.0
SLC6A3,REBOXETINE,has_refined_activity,60.0
SLC6A3,CHEMBL120490,has_refined_activity,10.9
SLC6A3,CHEMBL2079586,has_refined_activity,12.9
SLC6A3,NISOXETINE,has_refined_activity,30.0
SLC6A3,COCAINE,has_refined_activity,32.0
iPSC dopaminergic neuron maturation/readout assay,"DAT expression/function, dopamine uptake, neuron identity QC",measured_by,
PINK1,mitochondrial quality control,belongs_to_pathway,
PINK1,PINK1 knockout iPSC dopaminergic neurons,validated_in_model,
mitochondrial quality control,PRKN,belongs_to_pathway,
PINK1 knockout iPSC dopaminergic neurons,"mitophagy reporter, mitochondrial membrane potential, ATP/ROS",measured_by,
LAMP2,lysosome/autophagy,belongs_to_pathway,
LAMP2,iPSC dopaminergic neurons with lysosomal stress,validated_in_model,
iPSC dopaminergic neurons with lysosomal stress,"LC3/p62 flux, lysosomal pH, autophagosome clearance",measured_by,
MYD88,iPSC-derived microglia inflammatory challenge,validated_in_model,
iPSC-derived microglia inflammatory challenge,"NF-kB reporter, cytokine release, rescue of co-culture toxicity",measured_by,
NDUFS3,mitochondrial oxidative phosphorylation,belongs_to_pathway,
NDUFS3,iPSC dopaminergic neuron mitochondrial stress model,validated_in_model,
iPSC dopaminergic neuron mitochondrial stress model,"Seahorse OCR, complex I activity, ATP/ROS",measured_by,
PRKN,PRKN knockout iPSC dopaminergic neurons,validated_in_model,
PRKN knockout iPSC dopaminergic neurons,"mitophagy reporter, ubiquitination, mitochondrial stress survival",measured_by,