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aca95a6d5a1ba40d82a9c5787d428a42_0 | Architecturally, the school has a Catholic character. Atop the Main Building's gold dome is a golden statue of the Virgin Mary. Immediately in front of the Main Building and facing it, is a copper statue of Christ with arms upraised with the legend "Venite Ad Me Omnes". Next to the Main Building is the Basilica of the ... |
aca95a6d5a1ba40d82a9c5787d428a42_1 | As at most other universities, Notre Dame's students run a number of news media outlets. The nine student-run outlets include three newspapers, both a radio and television station, and several magazines and journals. Begun as a one-page journal in September 1876, the Scholastic magazine is issued twice monthly and clai... |
aca95a6d5a1ba40d82a9c5787d428a42_2 | The university is the major seat of the Congregation of Holy Cross (albeit not its official headquarters, which are in Rome). Its main seminary, Moreau Seminary, is located on the campus across St. Joseph lake from the Main Building. Old College, the oldest building on campus and located near the shore of St. Mary lake... |
aca95a6d5a1ba40d82a9c5787d428a42_3 | The College of Engineering was established in 1920, however, early courses in civil and mechanical engineering were a part of the College of Science since the 1870s. Today the college, housed in the Fitzpatrick, Cushing, and Stinson-Remick Halls of Engineering, includes five departments of study – aerospace and mechani... |
aca95a6d5a1ba40d82a9c5787d428a42_4 | All of Notre Dame's undergraduate students are a part of one of the five undergraduate colleges at the school or are in the First Year of Studies program. The First Year of Studies program was established in 1962 to guide incoming freshmen in their first year at the school before they have declared a major. Each studen... |
aca95a6d5a1ba40d82a9c5787d428a42_5 | The university first offered graduate degrees, in the form of a Master of Arts (MA), in the 1854–1855 academic year. The program expanded to include Master of Laws (LL.M.) and Master of Civil Engineering in its early stages of growth, before a formal graduate school education was developed with a thesis not required to... |
aca95a6d5a1ba40d82a9c5787d428a42_6 | The Joan B. Kroc Institute for International Peace Studies at the University of Notre Dame is dedicated to research, education and outreach on the causes of violent conflict and the conditions for sustainable peace. It offers PhD, Master's, and undergraduate degrees in peace studies. It was founded in 1986 through the ... |
aca95a6d5a1ba40d82a9c5787d428a42_7 | The library system of the university is divided between the main library and each of the colleges and schools. The main building is the 14-story Theodore M. Hesburgh Library, completed in 1963, which is the third building to house the main collection of books. The front of the library is adorned with the Word of Life m... |
aca95a6d5a1ba40d82a9c5787d428a42_8 | Notre Dame is known for its competitive admissions, with the incoming class enrolling in fall 2015 admitting 3,577 from a pool of 18,156 (19.7%). The academic profile of the enrolled class continues to rate among the top 10 to 15 in the nation for national research universities. The university practices a non-restricti... |
aca95a6d5a1ba40d82a9c5787d428a42_9 | In 2015-2016, Notre Dame ranked 18th overall among "national universities" in the United States in U.S. News & World Report's Best Colleges 2016. In 2014, USA Today ranked Notre Dame 10th overall for American universities based on data from College Factual. Forbes.com's America's Best Colleges ranks Notre Dame 13th amo... |
aca95a6d5a1ba40d82a9c5787d428a42_10 | Father Joseph Carrier, C.S.C. was Director of the Science Museum and the Library and Professor of Chemistry and Physics until 1874. Carrier taught that scientific research and its promise for progress were not antagonistic to the ideals of intellectual and moral culture endorsed by the Church. One of Carrier's students... |
aca95a6d5a1ba40d82a9c5787d428a42_11 | In 1882, Albert Zahm (John Zahm's brother) built an early wind tunnel used to compare lift to drag of aeronautical models. Around 1899, Professor Jerome Green became the first American to send a wireless message. In 1931, Father Julius Nieuwland performed early work on basic reactions that was used to create neoprene. ... |
aca95a6d5a1ba40d82a9c5787d428a42_12 | The Lobund Institute grew out of pioneering research in germ-free-life which began in 1928. This area of research originated in a question posed by Pasteur as to whether animal life was possible without bacteria. Though others had taken up this idea, their research was short lived and inconclusive. Lobund was the first... |
aca95a6d5a1ba40d82a9c5787d428a42_13 | The Review of Politics was founded in 1939 by Gurian, modeled after German Catholic journals. It quickly emerged as part of an international Catholic intellectual revival, offering an alternative vision to positivist philosophy. For 44 years, the Review was edited by Gurian, Matthew Fitzsimons, Frederick Crosson, and T... |
aca95a6d5a1ba40d82a9c5787d428a42_14 | As of 2012[update] research continued in many fields. The university president, John Jenkins, described his hope that Notre Dame would become "one of the pre–eminent research institutions in the world" in his inaugural address. The university has many multi-disciplinary institutes devoted to research in varying fields,... |
aca95a6d5a1ba40d82a9c5787d428a42_15 | In 2014 the Notre Dame student body consisted of 12,179 students, with 8,448 undergraduates, 2,138 graduate and professional and 1,593 professional (Law, M.Div., Business, M.Ed.) students. Around 21–24% of students are children of alumni, and although 37% of students come from the Midwestern United States, the student ... |
aca95a6d5a1ba40d82a9c5787d428a42_16 | About 80% of undergraduates and 20% of graduate students live on campus. The majority of the graduate students on campus live in one of four graduate housing complexes on campus, while all on-campus undergraduates live in one of the 29 residence halls. Because of the religious affiliation of the university, all residen... |
dc7d3caaa4fc4f835e58c233cc1c5eda_0 | Beyoncé Giselle Knowles-Carter (/biːˈjɒnseɪ/ bee-YON-say) (born September 4, 1981) is an American singer, songwriter, record producer and actress. Born and raised in Houston, Texas, she performed in various singing and dancing competitions as a child, and rose to fame in the late 1990s as lead singer of R&B girl-group ... |
dc7d3caaa4fc4f835e58c233cc1c5eda_1 | Following the disbandment of Destiny's Child in June 2005, she released her second solo album, B'Day (2006), which contained hits "Déjà Vu", "Irreplaceable", and "Beautiful Liar". Beyoncé also ventured into acting, with a Golden Globe-nominated performance in Dreamgirls (2006), and starring roles in The Pink Panther (2... |
dc7d3caaa4fc4f835e58c233cc1c5eda_2 | A self-described "modern-day feminist", Beyoncé creates songs that are often characterized by themes of love, relationships, and monogamy, as well as female sexuality and empowerment. On stage, her dynamic, highly choreographed performances have led to critics hailing her as one of the best entertainers in contemporary... |
dc7d3caaa4fc4f835e58c233cc1c5eda_3 | Beyoncé Giselle Knowles was born in Houston, Texas, to Celestine Ann "Tina" Knowles (née Beyincé), a hairdresser and salon owner, and Mathew Knowles, a Xerox sales manager. Beyoncé's name is a tribute to her mother's maiden name. Beyoncé's younger sister Solange is also a singer and a former member of Destiny's Child. ... |
dc7d3caaa4fc4f835e58c233cc1c5eda_4 | Beyoncé attended St. Mary's Elementary School in Fredericksburg, Texas, where she enrolled in dance classes. Her singing talent was discovered when dance instructor Darlette Johnson began humming a song and she finished it, able to hit the high-pitched notes. Beyoncé's interest in music and performing continued after w... |
dc7d3caaa4fc4f835e58c233cc1c5eda_5 | At age eight, Beyoncé and childhood friend Kelly Rowland met LaTavia Roberson while in an audition for an all-girl entertainment group. They were placed into a group with three other girls as Girl's Tyme, and rapped and danced on the talent show circuit in Houston. After seeing the group, R&B producer Arne Frager broug... |
dc7d3caaa4fc4f835e58c233cc1c5eda_6 | The group changed their name to Destiny's Child in 1996, based upon a passage in the Book of Isaiah. In 1997, Destiny's Child released their major label debut song "Killing Time" on the soundtrack to the 1997 film, Men in Black. The following year, the group released their self-titled debut album, scoring their first m... |
dc7d3caaa4fc4f835e58c233cc1c5eda_7 | LeToya Luckett and Roberson became unhappy with Mathew's managing of the band and eventually were replaced by Farrah Franklin and Michelle Williams. Beyoncé experienced depression following the split with Luckett and Roberson after being publicly blamed by the media, critics, and blogs for its cause. Her long-standing ... |
dc7d3caaa4fc4f835e58c233cc1c5eda_8 | The remaining band members recorded "Independent Women Part I", which appeared on the soundtrack to the 2000 film, Charlie's Angels. It became their best-charting single, topping the U.S. Billboard Hot 100 chart for eleven consecutive weeks. In early 2001, while Destiny's Child was completing their third album, Beyoncé... |
dc7d3caaa4fc4f835e58c233cc1c5eda_9 | In July 2002, Beyoncé continued her acting career playing Foxxy Cleopatra alongside Mike Myers in the comedy film, Austin Powers in Goldmember, which spent its first weekend atop the US box office and grossed $73 million. Beyoncé released "Work It Out" as the lead single from its soundtrack album which entered the top ... |
dc7d3caaa4fc4f835e58c233cc1c5eda_10 | Beyoncé's first solo recording was a feature on Jay Z's "'03 Bonnie & Clyde" that was released in October 2002, peaking at number four on the U.S. Billboard Hot 100 chart. Her first solo album Dangerously in Love was released on June 24, 2003, after Michelle Williams and Kelly Rowland had released their solo efforts. T... |
dc7d3caaa4fc4f835e58c233cc1c5eda_11 | In November 2003, she embarked on the Dangerously in Love Tour in Europe and later toured alongside Missy Elliott and Alicia Keys for the Verizon Ladies First Tour in North America. On February 1, 2004, Beyoncé performed the American national anthem at Super Bowl XXXVIII, at the Reliant Stadium in Houston, Texas. After... |
dc7d3caaa4fc4f835e58c233cc1c5eda_12 | Beyoncé's second solo album B'Day was released on September 5, 2006, in the US, to coincide with her twenty-fifth birthday. It sold 541,000 copies in its first week and debuted atop the Billboard 200, becoming Beyoncé's second consecutive number-one album in the United States. The album's lead single "Déjà Vu", featuri... |
dc7d3caaa4fc4f835e58c233cc1c5eda_13 | Her first acting role of 2006 was in the comedy film The Pink Panther starring opposite Steve Martin, grossing $158.8 million at the box office worldwide. Her second film Dreamgirls, the film version of the 1981 Broadway musical loosely based on The Supremes, received acclaim from critics and grossed $154 million inter... |
a8088b760fb315d2964735686800b203_0 | Montana i/mɒnˈtænə/ is a state in the Western region of the United States. The state's name is derived from the Spanish word montaña (mountain). Montana has several nicknames, although none official, including "Big Sky Country" and "The Treasure State", and slogans that include "Land of the Shining Mountains" and more ... |
a8088b760fb315d2964735686800b203_1 | Montana schoolchildren played a significant role in selecting several state symbols. The state tree, the ponderosa pine, was selected by Montana schoolchildren as the preferred state tree by an overwhelming majority in a referendum held in 1908. However, the legislature did not designate a state tree until 1949, when t... |
a8088b760fb315d2964735686800b203_2 | The state song was not composed until 21 years after statehood, when a musical troupe led by Joseph E. Howard stopped in Butte in September 1910. A former member of the troupe who lived in Butte buttonholed Howard at an after-show party, asking him to compose a song about Montana and got another partygoer, the city edi... |
a8088b760fb315d2964735686800b203_3 | Montana's motto, Oro y Plata, Spanish for "Gold and Silver", recognizing the significant role of mining, was first adopted in 1865, when Montana was still a territory. A state seal with a miner's pick and shovel above the motto, surrounded by the mountains and the Great Falls of the Missouri River, was adopted during t... |
a8088b760fb315d2964735686800b203_4 | The state also has five Micropolitan Statistical Areas centered on Bozeman, Butte, Helena, Kalispell and Havre. These communities, excluding Havre, are colloquially known as the "big 7" Montana cities, as they are consistently the seven largest communities in Montana, with a significant population difference when these... |
a8088b760fb315d2964735686800b203_5 | Montana has 56 counties with the United States Census Bureau stating Montana's contains 364 "places", broken down into 129 incorporated places and 235 census-designated places. Incorporated places consist of 52 cities, 75 towns, and two consolidated city-counties. Montana has one city, Billings, with a population over ... |
a8088b760fb315d2964735686800b203_6 | The name Montana comes from the Spanish word Montaña, meaning "mountain", or more broadly, "mountainous country". Montaña del Norte was the name given by early Spanish explorers to the entire mountainous region of the west. The name Montana was added to a bill by the United States House Committee on Territories, which ... |
a8088b760fb315d2964735686800b203_7 | With a total area of 147,040 square miles (380,800 km2), Montana is slightly larger than Japan. It is the fourth largest state in the United States after Alaska, Texas, and California; the largest landlocked U.S. state; and the 56th largest national state/province subdivision in the world. To the north, Montana shares ... |
a8088b760fb315d2964735686800b203_8 | The topography of the state is roughly defined by the Continental Divide, which splits much of the state into distinct eastern and western regions. Most of Montana's 100 or more named mountain ranges are concentrated in the western half of the state, most of which is geologically and geographically part of the Northern... |
a8088b760fb315d2964735686800b203_9 | The northern section of the Divide, where the mountains give way rapidly to prairie, is part of the Rocky Mountain Front. The front is most pronounced in the Lewis Range, located primarily in Glacier National Park. Due to the configuration of mountain ranges in Glacier National Park, the Northern Divide (which begins i... |
a8088b760fb315d2964735686800b203_10 | East of the divide, several roughly parallel ranges cover the southern part of the state, including the Gravelly Range, the Madison Range, Gallatin Range, Absaroka Mountains and the Beartooth Mountains. The Beartooth Plateau is the largest continuous land mass over 10,000 feet (3,000 m) high in the continental United S... |
a8088b760fb315d2964735686800b203_11 | However, at the state level, the pattern of split ticket voting and divided government holds. Democrats currently hold one of the state's U.S. Senate seats, as well as four of the five statewide offices (Governor, Superintendent of Public Instruction, Secretary of State and State Auditor). The lone congressional distri... |
a8088b760fb315d2964735686800b203_12 | In presidential elections, Montana was long classified as a swing state, though the state has voted for the Republican candidate in all but two elections from 1952 to the present. The state last supported a Democrat for president in 1992, when Bill Clinton won a plurality victory. Overall, since 1889 the state has vote... |
a8088b760fb315d2964735686800b203_13 | Bozeman Yellowstone International Airport is the busiest airport in the state of Montana, surpassing Billings Logan International Airport in the spring of 2013. Montana's other major Airports include Billings Logan International Airport, Missoula International Airport, Great Falls International Airport, Glacier Park In... |
a8088b760fb315d2964735686800b203_14 | Railroads have been an important method of transportation in Montana since the 1880s. Historically, the state was traversed by the main lines of three east-west transcontinental routes: the Milwaukee Road, the Great Northern, and the Northern Pacific. Today, the BNSF Railway is the state's largest railroad, its main tr... |
a8088b760fb315d2964735686800b203_15 | Montana is home to the Rocky Mountain Elk Foundation and has a historic big game hunting tradition. There are fall bow and general hunting seasons for elk, pronghorn antelope, whitetail deer and mule deer. A random draw grants a limited number of permits for moose, mountain goats and bighorn sheep. There is a spring hu... |
a8088b760fb315d2964735686800b203_16 | Montana has been a destination for its world-class trout fisheries since the 1930s. Fly fishing for several species of native and introduced trout in rivers and lakes is popular for both residents and tourists throughout the state. Montana is the home of the Federation of Fly Fishers and hosts many of the organizations... |
a8088b760fb315d2964735686800b203_17 | The Montana Territory was formed on April 26, 1864, when the U.S. passed the Organic Act. Schools started forming in the area before it was officially a territory as families started settling into the area. The first schools were subscription schools that typically held in the teacher's home. The first formal school on... |
a8088b760fb315d2964735686800b203_18 | Montana contains thousands of named rivers and creeks, 450 miles (720 km) of which are known for "blue-ribbon" trout fishing. Montana's water resources provide for recreation, hydropower, crop and forage irrigation, mining, and water for human consumption. Montana is one of few geographic areas in the world whose river... |
a30a2d82c2ae2abc7d8e674df992d57e_0 | The phrase "in whole or in part" has been subject to much discussion by scholars of international humanitarian law. The International Criminal Tribunal for the Former Yugoslavia found in Prosecutor v. Radislav Krstic – Trial Chamber I – Judgment – IT-98-33 (2001) ICTY8 (2 August 2001) that Genocide had been committed. ... |
a30a2d82c2ae2abc7d8e674df992d57e_1 | In the same judgement the ECHR reviewed the judgements of several international and municipal courts judgements. It noted that International Criminal Tribunal for the Former Yugoslavia and the International Court of Justice had agreed with the narrow interpretation, that biological-physical destruction was necessary fo... |
a30a2d82c2ae2abc7d8e674df992d57e_2 | After the Holocaust, which had been perpetrated by the Nazi Germany and its allies prior to and during World War II, Lemkin successfully campaigned for the universal acceptance of international laws defining and forbidding genocides. In 1946, the first session of the United Nations General Assembly adopted a resolution... |
a30a2d82c2ae2abc7d8e674df992d57e_3 | The first draft of the Convention included political killings, but these provisions were removed in a political and diplomatic compromise following objections from some countries, including the USSR, a permanent security council member. The USSR argued that the Convention's definition should follow the etymology of the... |
a30a2d82c2ae2abc7d8e674df992d57e_4 | In 2007 the European Court of Human Rights (ECHR), noted in its judgement on Jorgic v. Germany case that in 1992 the majority of legal scholars took the narrow view that "intent to destroy" in the CPPCG meant the intended physical-biological destruction of the protected group and that this was still the majority opinio... |
a30a2d82c2ae2abc7d8e674df992d57e_5 | The word genocide was later included as a descriptive term to the process of indictment, but not yet as a formal legal term According to Lemming, genocide was defined as "a coordinated strategy to destroy a group of people, a process that could be accomplished through total annihilation as well as strategies that elimi... |
a30a2d82c2ae2abc7d8e674df992d57e_6 | The study of genocide has mainly been focused towards the legal aspect of the term. By formally recognizing the act of genocide as a crime, involves the undergoing prosecution that begins with not only seeing genocide as outrageous past any moral standpoint but also may be a legal liability within international relatio... |
a30a2d82c2ae2abc7d8e674df992d57e_7 | Genocide has become an official term used in international relations. The word genocide was not in use before 1944. Before this, in 1941, Winston Churchill described the mass killing of Russian prisoners of war and civilians as "a crime without a name". In that year, a Polish-Jewish lawyer named Raphael Lemkin, describ... |
a30a2d82c2ae2abc7d8e674df992d57e_8 | The judges continue in paragraph 12, "The determination of when the targeted part is substantial enough to meet this requirement may involve a number of considerations. The numeric size of the targeted part of the group is the necessary and important starting point, though not in all cases the ending point of the inqui... |
a30a2d82c2ae2abc7d8e674df992d57e_9 | In paragraph 13 the judges raise the issue of the perpetrators' access to the victims: "The historical examples of genocide also suggest that the area of the perpetrators’ activity and control, as well as the possible extent of their reach, should be considered. ... The intent to destroy formed by a perpetrator of geno... |
a30a2d82c2ae2abc7d8e674df992d57e_10 | The Convention came into force as international law on 12 January 1951 after the minimum 20 countries became parties. At that time however, only two of the five permanent members of the UN Security Council were parties to the treaty: France and the Republic of China. The Soviet Union ratified in 1954, the United Kingdo... |
a30a2d82c2ae2abc7d8e674df992d57e_11 | Writing in 1998 Kurt Jonassohn and Karin Björnson stated that the CPPCG was a legal instrument resulting from a diplomatic compromise. As such the wording of the treaty is not intended to be a definition suitable as a research tool, and although it is used for this purpose, as it has an international legal credibility ... |
a30a2d82c2ae2abc7d8e674df992d57e_12 | Jonassohn and Björnson postulate that the major reason why no single generally accepted genocide definition has emerged is because academics have adjusted their focus to emphasise different periods and have found it expedient to use slightly different definitions to help them interpret events. For example, Frank Chalk ... |
a30a2d82c2ae2abc7d8e674df992d57e_13 | The exclusion of social and political groups as targets of genocide in the CPPCG legal definition has been criticized by some historians and sociologists, for example M. Hassan Kakar in his book The Soviet Invasion and the Afghan Response, 1979–1982 argues that the international definition of genocide is too restricted... |
a30a2d82c2ae2abc7d8e674df992d57e_14 | Barbara Harff and Ted Gurr defined genocide as "the promotion and execution of policies by a state or its agents which result in the deaths of a substantial portion of a group ...[when] the victimized groups are defined primarily in terms of their communal characteristics, i.e., ethnicity, religion or nationality." Har... |
a30a2d82c2ae2abc7d8e674df992d57e_15 | According to R. J. Rummel, genocide has 3 different meanings. The ordinary meaning is murder by government of people due to their national, ethnic, racial, or religious group membership. The legal meaning of genocide refers to the international treaty, the Convention on the Prevention and Punishment of the Crime of Gen... |
a30a2d82c2ae2abc7d8e674df992d57e_16 | Highlighting the potential for state and non-state actors to commit genocide in the 21st century, for example, in failed states or as non-state actors acquire weapons of mass destruction, Adrian Gallagher defined genocide as 'When a source of collective power (usually a state) intentionally uses its power base to imple... |
a30a2d82c2ae2abc7d8e674df992d57e_17 | All signatories to the CPPCG are required to prevent and punish acts of genocide, both in peace and wartime, though some barriers make this enforcement difficult. In particular, some of the signatories—namely, Bahrain, Bangladesh, India, Malaysia, the Philippines, Singapore, the United States, Vietnam, Yemen, and forme... |
a30a2d82c2ae2abc7d8e674df992d57e_18 | Because the universal acceptance of international laws which in 1948 defined and forbade genocide with the promulgation of the Convention on the Prevention and Punishment of the Crime of Genocide (CPPCG), those criminals who were prosecuted after the war in international courts for taking part in the Holocaust were fou... |
a30a2d82c2ae2abc7d8e674df992d57e_19 | On 12 July 2007, European Court of Human Rights when dismissing the appeal by Nikola Jorgić against his conviction for genocide by a German court (Jorgic v. Germany) noted that the German courts wider interpretation of genocide has since been rejected by international courts considering similar cases. The ECHR also not... |
445236f3cc0cda3bb87208a67be7d3f4_0 | The emergence of resistance of bacteria to antibiotics is a common phenomenon. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of... |
445236f3cc0cda3bb87208a67be7d3f4_1 | The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial gr... |
445236f3cc0cda3bb87208a67be7d3f4_2 | Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essentia... |
445236f3cc0cda3bb87208a67be7d3f4_3 | With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are ... |
445236f3cc0cda3bb87208a67be7d3f4_4 | Antibiotics revolutionized medicine in the 20th century, and have together with vaccination led to the near eradication of diseases such as tuberculosis in the developed world. Their effectiveness and easy access led to overuse, especially in livestock raising, prompting bacteria to develop resistance. This has led to ... |
445236f3cc0cda3bb87208a67be7d3f4_5 | In empirical therapy, a patient has proven or suspected infection, but the responsible microorganism is not yet unidentified. While the microorgainsim is being identified the doctor will usually administer the best choice of antibiotic that will be most active against the likely cause of infection usually a broad spect... |
445236f3cc0cda3bb87208a67be7d3f4_6 | Antibiotics are screened for any negative effects on humans or other mammals before approval for clinical use, and are usually considered safe and most are well tolerated. However, some antibiotics have been associated with a range of adverse side effects. Side-effects range from mild to very serious depending on the a... |
445236f3cc0cda3bb87208a67be7d3f4_7 | Exposure to antibiotics early in life is associated with increased body mass in humans and mouse models. Early life is a critical period for the establishment of the intestinal microbiota and for metabolic development. Mice exposed to subtherapeutic antibiotic treatment (STAT)– with either penicillin, vancomycin, penic... |
445236f3cc0cda3bb87208a67be7d3f4_8 | The majority of studies indicate antibiotics do interfere with contraceptive pills, such as clinical studies that suggest the failure rate of contraceptive pills caused by antibiotics is very low (about 1%). In cases where antibacterials have been suggested to affect the efficiency of birth control pills, such as for t... |
445236f3cc0cda3bb87208a67be7d3f4_9 | Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious ... |
445236f3cc0cda3bb87208a67be7d3f4_10 | Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition... |
445236f3cc0cda3bb87208a67be7d3f4_11 | Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled. For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeuti... |
445236f3cc0cda3bb87208a67be7d3f4_12 | Inappropriate antibiotic treatment and overuse of antibiotics have contributed to the emergence of antibiotic-resistant bacteria. Self prescription of antibiotics is an example of misuse. Many antibiotics are frequently prescribed to treat symptoms or diseases that do not respond to antibiotics or that are likely to re... |
445236f3cc0cda3bb87208a67be7d3f4_13 | Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course o... |
445236f3cc0cda3bb87208a67be7d3f4_14 | Several organizations concerned with antimicrobial resistance are lobbying to eliminate the unnecessary use of antibiotics. The issues of misuse and overuse of antibiotics have been addressed by the formation of the US Interagency Task Force on Antimicrobial Resistance. This task force aims to actively address antimicr... |
445236f3cc0cda3bb87208a67be7d3f4_15 | The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Associatio... |
445236f3cc0cda3bb87208a67be7d3f4_16 | There has been extensive use of antibiotics in animal husbandry. In the United States, the question of emergence of antibiotic-resistant bacterial strains due to use of antibiotics in livestock was raised by the US Food and Drug Administration (FDA) in 1977. In March 2012, the United States District Court for the South... |
445236f3cc0cda3bb87208a67be7d3f4_17 | Before the early 20th century, treatments for infections were based primarily on medicinal folklore. Mixtures with antimicrobial properties that were used in treatments of infections were described over 2000 years ago. Many ancient cultures, including the ancient Egyptians and ancient Greeks, used specially selected mo... |
d24f03ba35265820239f6eb574d327b0_0 | Frédéric François Chopin (/ˈʃoʊpæn/; French pronunciation: [fʁe.de.ʁik fʁɑ̃.swa ʃɔ.pɛ̃]; 22 February or 1 March 1810 – 17 October 1849), born Fryderyk Franciszek Chopin,[n 1] was a Polish and French (by citizenship and birth of father) composer and a virtuoso pianist of the Romantic era, who wrote primarily for the so... |
d24f03ba35265820239f6eb574d327b0_1 | At the age of 21 he settled in Paris. Thereafter, during the last 18 years of his life, he gave only some 30 public performances, preferring the more intimate atmosphere of the salon. He supported himself by selling his compositions and teaching piano, for which he was in high demand. Chopin formed a friendship with Fr... |
d24f03ba35265820239f6eb574d327b0_2 | All of Chopin's compositions include the piano. Most are for solo piano, though he also wrote two piano concertos, a few chamber pieces, and some songs to Polish lyrics. His keyboard style is highly individual and often technically demanding; his own performances were noted for their nuance and sensitivity. Chopin inve... |
d24f03ba35265820239f6eb574d327b0_3 | In his native Poland, in France, where he composed most of his works, and beyond, Chopin's music, his status as one of music's earliest superstars, his association (if only indirect) with political insurrection, his love life and his early death have made him, in the public consciousness, a leading symbol of the Romant... |
d24f03ba35265820239f6eb574d327b0_4 | Fryderyk Chopin was born in Żelazowa Wola, 46 kilometres (29 miles) west of Warsaw, in what was then the Duchy of Warsaw, a Polish state established by Napoleon. The parish baptismal record gives his birthday as 22 February 1810, and cites his given names in the Latin form Fridericus Franciscus (in Polish, he was Fryde... |
d24f03ba35265820239f6eb574d327b0_5 | Fryderyk's father, Nicolas Chopin, was a Frenchman from Lorraine who had emigrated to Poland in 1787 at the age of sixteen. Nicolas tutored children of the Polish aristocracy, and in 1806 married Justyna Krzyżanowska, a poor relative of the Skarbeks, one of the families for whom he worked. Fryderyk was baptized on East... |
d24f03ba35265820239f6eb574d327b0_6 | In October 1810, six months after Fryderyk's birth, the family moved to Warsaw, where his father acquired a post teaching French at the Warsaw Lyceum, then housed in the Saxon Palace. Fryderyk lived with his family in the Palace grounds. The father played the flute and violin; the mother played the piano and gave lesso... |
d24f03ba35265820239f6eb574d327b0_7 | Fryderyk may have had some piano instruction from his mother, but his first professional music tutor, from 1816 to 1821, was the Czech pianist Wojciech Żywny. His elder sister Ludwika also took lessons from Żywny, and occasionally played duets with her brother. It quickly became apparent that he was a child prodigy. By... |
d24f03ba35265820239f6eb574d327b0_8 | In 1817 the Saxon Palace was requisitioned by Warsaw's Russian governor for military use, and the Warsaw Lyceum was reestablished in the Kazimierz Palace (today the rectorate of Warsaw University). Fryderyk and his family moved to a building, which still survives, adjacent to the Kazimierz Palace. During this period, F... |
d24f03ba35265820239f6eb574d327b0_9 | From September 1823 to 1826 Chopin attended the Warsaw Lyceum, where he received organ lessons from the Czech musician Wilhelm Würfel during his first year. In the autumn of 1826 he began a three-year course under the Silesian composer Józef Elsner at the Warsaw Conservatory, studying music theory, figured bass and com... |
d24f03ba35265820239f6eb574d327b0_10 | During 1824–28 Chopin spent his vacations away from Warsaw, at a number of locales.[n 4] In 1824 and 1825, at Szafarnia, he was a guest of Dominik Dziewanowski, the father of a schoolmate. Here for the first time he encountered Polish rural folk music. His letters home from Szafarnia (to which he gave the title "The Sz... |
d24f03ba35265820239f6eb574d327b0_11 | In 1827, soon after the death of Chopin's youngest sister Emilia, the family moved from the Warsaw University building, adjacent to the Kazimierz Palace, to lodgings just across the street from the university, in the south annex of the Krasiński Palace on Krakowskie Przedmieście,[n 5] where Chopin lived until he left W... |
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