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{
"copasiOptimizationMethod": {
"optimizationMethodType": "evolutionaryProgram",
"optimizationParameter": [
{
"dataType": "int",
"paramType": "numberOfGenerations",
"value": 200.0
},
{
"dataType": "int",
"paramType": "populationSize",
"value": 20.0
},
{
"dataType": "int",
"paramType": "randomNumberGenerator",
"value": 1.0
},
{
"dataType": "int",
"paramType": "seed",
"value": 0.0
}
]
},
"dataSet": [
[
0.0,
4.0
],
[
1.295720285971286E-4,
3.999611366663021
],
[
4.924083761030788E-4,
3.998523873442699
],
[
0.003065662851935472,
3.990845173277069
],
[
0.0076815973758065205,
3.9772186929899127
],
[
0.014574181044930384,
3.957219491908877
],
[
0.02497272803898938,
3.92781938129364
],
[
0.040662945860187746,
3.8851582405505694
],
[
0.07469412103283095,
3.799249276503241
],
[
0.10735857823648513,
3.724643285643995
],
[
0.15042425159162362,
3.636817112208214
],
[
0.2109351969932674,
3.531099655992511
],
[
0.29257831007997415,
3.4157235027261508
],
[
0.37422142316668094,
3.325411678114914
],
[
0.45586453625338774,
3.2547192053620813
],
[
0.5375076493400945,
3.1993839741215537
],
[
0.6191507624268013,
3.156069775277858
],
[
0.7007938755135081,
3.1221651582678236
],
[
0.7824369886002149,
3.0956259843893053
],
[
0.8640801016869217,
3.0748521838801746
],
[
0.9457232147736285,
3.058591286326842
],
[
1.0,
3.049787087039816
]
],
"mathModelSbmlContents": "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/level2/version4\" level=\"2\" version=\"4\">\n <model id=\"MathModel_NoName\">\n <listOfCompartments>\n <compartment id=\"compartment\"/>\n </listOfCompartments>\n <listOfParameters>\n <parameter constant=\"true\" id=\"_F_\" value=\"9.64853321E4\"/>\n <parameter constant=\"true\" id=\"_F_nmol_\" value=\"9.64853321E-5\"/>\n <parameter constant=\"true\" id=\"_K_GHK_\" value=\"1E-9\"/>\n <parameter constant=\"true\" id=\"_N_pmol_\" value=\"6.02214179E11\"/>\n <parameter constant=\"true\" id=\"_PI_\" value=\"3.141592653589793\"/>\n <parameter constant=\"true\" id=\"_R_\" value=\"8314.46261815\"/>\n <parameter constant=\"true\" id=\"_T_\" value=\"300\"/>\n <parameter constant=\"true\" id=\"K_millivolts_per_volt\" value=\"1000\"/>\n <parameter constant=\"true\" id=\"Kf\" value=\"1\"/>\n <parameter constant=\"true\" id=\"KMOLE\" value=\"0.001660538783162726\"/>\n <parameter constant=\"true\" id=\"Kr\" value=\"2\"/>\n <parameter constant=\"true\" id=\"s0_init_uM\" value=\"5\"/>\n <parameter constant=\"true\" id=\"s1_init_uM\" value=\"4\"/>\n <parameter constant=\"true\" id=\"Size_c0\" value=\"50000\"/>\n <parameter constant=\"false\" id=\"J_r0\"/>\n <parameter constant=\"false\" id=\"s0\"/>\n <parameter constant=\"false\" id=\"s1\"/>\n </listOfParameters>\n <listOfInitialAssignments>\n <initialAssignment id=\"ID_2\" symbol=\"s0\">\n <math xmlns=\"http://www.w3.org/1998/Math/MathML\"> \n <ci> s0_init_uM </ci>\n </math>\n </initialAssignment>\n <initialAssignment id=\"ID_3\" symbol=\"s1\">\n <math xmlns=\"http://www.w3.org/1998/Math/MathML\"> \n <ci> s1_init_uM </ci>\n </math>\n </initialAssignment>\n </listOfInitialAssignments>\n <listOfRules>\n <assignmentRule id=\"ID_1\" variable=\"J_r0\">\n <math xmlns=\"http://www.w3.org/1998/Math/MathML\"> \n <apply>\n <plus/>\n <apply>\n <times/>\n <ci> Kf </ci>\n <ci> s0 </ci>\n </apply>\n <apply>\n <minus/>\n <apply>\n <times/>\n <ci> Kr </ci>\n <ci> s1 </ci>\n </apply>\n </apply>\n </apply>\n </math>\n </assignmentRule>\n <rateRule variable=\"s0\">\n <math xmlns=\"http://www.w3.org/1998/Math/MathML\"> \n <apply>\n <minus/>\n <ci> J_r0 </ci>\n </apply>\n </math>\n </rateRule>\n <rateRule variable=\"s1\">\n <math xmlns=\"http://www.w3.org/1998/Math/MathML\"> \n <ci> J_r0 </ci>\n </math>\n </rateRule>\n </listOfRules>\n </model>\n</sbml>",
"numberOfOptimizationRuns": 1,
"parameterDescriptionList": [
{
"initialValue": 0.2,
"maxValue": 10.0,
"minValue": 0.1,
"name": "Kf",
"scale": 0.2
},
{
"initialValue": 0.3,
"maxValue": 20.0,
"minValue": 0.2,
"name": "Kr",
"scale": 0.3
},
{
"initialValue": 2.0,
"maxValue": 20.0,
"minValue": 1.0E-8,
"name": "s0_init_uM",
"scale": 2.0
}
],
"referenceVariable": [
{
"referenceVariableType": "independent",
"varName": "t"
},
{
"referenceVariableType": "dependent",
"varName": "s1"
}
]
} |