{
    "copasiOptimizationMethod": {
        "optimizationMethodType": "evolutionaryProgram",
        "optimizationParameter": [
            {
                "dataType": "int",
                "paramType": "numberOfGenerations",
                "value": 200.0
            },
            {
                "dataType": "int",
                "paramType": "populationSize",
                "value": 20.0
            },
            {
                "dataType": "int",
                "paramType": "randomNumberGenerator",
                "value": 1.0
            },
            {
                "dataType": "int",
                "paramType": "seed",
                "value": 0.0
            }
        ]
    },
    "dataSet": [
        [
            0.0,
            4.0
        ],
        [
            1.295720285971286E-4,
            3.999611366663021
        ],
        [
            4.924083761030788E-4,
            3.998523873442699
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            0.003065662851935472,
            3.990845173277069
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            0.0076815973758065205,
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            3.92781938129364
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            3.8851582405505694
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            3.799249276503241
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            0.5375076493400945,
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        [
            0.6191507624268013,
            3.156069775277858
        ],
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            0.7007938755135081,
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        ],
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            0.7824369886002149,
            3.0956259843893053
        ],
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            0.8640801016869217,
            3.0748521838801746
        ],
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            0.9457232147736285,
            3.058591286326842
        ],
        [
            1.0,
            3.049787087039816
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    ],
    "mathModelSbmlContents": "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/level2/version4\" level=\"2\" version=\"4\">\n  <model id=\"MathModel_NoName\">\n    <listOfCompartments>\n      <compartment id=\"compartment\"/>\n    </listOfCompartments>\n    <listOfParameters>\n      <parameter constant=\"true\" id=\"_F_\" value=\"9.64853321E4\"/>\n      <parameter constant=\"true\" id=\"_F_nmol_\" value=\"9.64853321E-5\"/>\n      <parameter constant=\"true\" id=\"_K_GHK_\" value=\"1E-9\"/>\n      <parameter constant=\"true\" id=\"_N_pmol_\" value=\"6.02214179E11\"/>\n      <parameter constant=\"true\" id=\"_PI_\" value=\"3.141592653589793\"/>\n      <parameter constant=\"true\" id=\"_R_\" value=\"8314.46261815\"/>\n      <parameter constant=\"true\" id=\"_T_\" value=\"300\"/>\n      <parameter constant=\"true\" id=\"K_millivolts_per_volt\" value=\"1000\"/>\n      <parameter constant=\"true\" id=\"Kf\" value=\"1\"/>\n      <parameter constant=\"true\" id=\"KMOLE\" value=\"0.001660538783162726\"/>\n      <parameter constant=\"true\" id=\"Kr\" value=\"2\"/>\n      <parameter constant=\"true\" id=\"s0_init_uM\" value=\"5\"/>\n      <parameter constant=\"true\" id=\"s1_init_uM\" value=\"4\"/>\n      <parameter constant=\"true\" id=\"Size_c0\" value=\"50000\"/>\n      <parameter constant=\"false\" id=\"J_r0\"/>\n      <parameter constant=\"false\" id=\"s0\"/>\n      <parameter constant=\"false\" id=\"s1\"/>\n    </listOfParameters>\n    <listOfInitialAssignments>\n      <initialAssignment id=\"ID_2\" symbol=\"s0\">\n        <math xmlns=\"http://www.w3.org/1998/Math/MathML\">        \n          <ci> s0_init_uM </ci>\n        </math>\n            </initialAssignment>\n      <initialAssignment id=\"ID_3\" symbol=\"s1\">\n        <math xmlns=\"http://www.w3.org/1998/Math/MathML\">        \n          <ci> s1_init_uM </ci>\n        </math>\n            </initialAssignment>\n    </listOfInitialAssignments>\n    <listOfRules>\n      <assignmentRule id=\"ID_1\" variable=\"J_r0\">\n        <math xmlns=\"http://www.w3.org/1998/Math/MathML\">        \n          <apply>\n            <plus/>\n            <apply>\n              <times/>\n              <ci> Kf </ci>\n              <ci> s0 </ci>\n            </apply>\n            <apply>\n              <minus/>\n              <apply>\n                <times/>\n                <ci> Kr </ci>\n                <ci> s1 </ci>\n              </apply>\n            </apply>\n          </apply>\n        </math>\n            </assignmentRule>\n      <rateRule variable=\"s0\">\n        <math xmlns=\"http://www.w3.org/1998/Math/MathML\">        \n          <apply>\n            <minus/>\n            <ci> J_r0 </ci>\n          </apply>\n        </math>\n            </rateRule>\n      <rateRule variable=\"s1\">\n        <math xmlns=\"http://www.w3.org/1998/Math/MathML\">        \n          <ci> J_r0 </ci>\n        </math>\n            </rateRule>\n    </listOfRules>\n  </model>\n</sbml>",
    "numberOfOptimizationRuns": 1,
    "parameterDescriptionList": [
        {
            "initialValue": 0.2,
            "maxValue": 10.0,
            "minValue": 0.1,
            "name": "Kf",
            "scale": 0.2
        },
        {
            "initialValue": 0.3,
            "maxValue": 20.0,
            "minValue": 0.2,
            "name": "Kr",
            "scale": 0.3
        },
        {
            "initialValue": 2.0,
            "maxValue": 20.0,
            "minValue": 1.0E-8,
            "name": "s0_init_uM",
            "scale": 2.0
        }
    ],
    "referenceVariable": [
        {
            "referenceVariableType": "independent",
            "varName": "t"
        },
        {
            "referenceVariableType": "dependent",
            "varName": "s1"
        }
    ]
}