// Copyright (C) 2019 - 2020 by Pedro Mendes, Rector and Visitors of the // University of Virginia, University of Heidelberg, and University // of Connecticut School of Medicine. // All rights reserved. // Copyright (C) 2017 - 2018 by Pedro Mendes, Virginia Tech Intellectual // Properties, Inc., University of Heidelberg, and University of // of Connecticut School of Medicine. // All rights reserved. // Copyright (C) 2015 - 2016 by Pedro Mendes, Virginia Tech Intellectual // Properties, Inc., University of Heidelberg, and The University // of Manchester. // All rights reserved. #define COPASI_MAIN #include #include #include #include "copasi/copasi.h" #include "copasi/CopasiDataModel/CDataModel.h" #include "copasi/core/CRootContainer.h" #include "copasi/model/CMetab.h" #include "copasi/core/CRegisteredCommonName.h" #include "copasi/core/CDataVector.h" #include "copasi/model/CModel.h" #include "copasi/utilities/CCopasiException.h" #include "copasi/commandline/COptionParser.h" #include "copasi/commandline/COptions.h" #include "copasi/trajectory/CTrajectoryTask.h" #include "copasi/trajectory/CTrajectoryMethod.h" #include "copasi/trajectory/CTrajectoryProblem.h" #include "copasi/steadystate/CSteadyStateTask.h" #include "copasi/steadystate/CSteadyStateMethod.h" #include "copasi/steadystate/CSteadyStateProblem.h" #include "copasi/steadystate/CMCATask.h" #include "copasi/steadystate/CMCAMethod.h" #include "copasi/steadystate/CMCAProblem.h" #include "copasi/report/CReportDefinitionVector.h" #include "copasi/report/CReportDefinition.h" int main(int argc, char *argv[]) { // Parse the commandline options // 1. argument is the SBML filename // 2. argument is the filename where the results are to be written try { // Create the root container. CRootContainer::init(0, NULL, false); } catch (copasi::autoexcept &e) {} catch (copasi::option_error &e) {} if (argc < 3) { std::cout << "Usage: mca_test_wrapper SBMLFILENAME OUTPUTFILE_PREFIX" << std::endl; exit(1); } char* pSBMLFilename = argv[1]; const char* pOutputFilename = argv[2]; std::string CWD = COptions::getPWD(); try { // Create the global data model. CDataModel* pDataModel = CRootContainer::addDatamodel(); // Import the SBML File pDataModel->importSBML(pSBMLFilename); // create a report with the correct filename and all the species against // time. CReportDefinitionVector* pReports = pDataModel->getReportDefinitionList(); CReportDefinition* pSteadyStateReport = &(*pReports)["Steady-State"]; CReportDefinition* pReport = &(*pReports)["Metabolic Control Analysis"]; //**** create a task **** CMCATask* pMCATask = new CMCATask(pDataModel); //pMCATask->setMethodType(CCopasiMethod::Newton); pMCATask->getProblem()->setModel(pDataModel->getModel()); pMCATask->setScheduled(true); pMCATask->getReport().setReportDefinition(pSteadyStateReport); pMCATask->getReport().setTarget(pOutputFilename + std::string(".res1")); pMCATask->getReport().setAppend(false); //**** specify problem **** CMCAProblem* pProblem = dynamic_cast(pMCATask->getProblem()); //pProblem->setStepNumber((const unsigned C_INT32)stepNumber); //pDataModel->getModel()->setInitialTime((const C_FLOAT64)startTime); //**** method settings **** CMCAMethod* pMethod = dynamic_cast(pMCATask->getMethod()); pMethod->getParameter("Maximum duration for forward integration")->setValue(1.0e5); pMethod->getParameter("Use Back Integration")->setValue(false); pMethod->getParameter("Maximum duration for backward integration")->setValue(1.0e3); //pMethod->getParameter("Absolute Tolerance")->setValue(1.0e-12); //***** run the task ********* CDataVectorN< CCopasiTask > & TaskList = * pDataModel->getTaskList(); TaskList.remove("Metabolic Control Analysis"); TaskList.add(pMCATask, true); // save the file for control purposes std::string saveFilename = pOutputFilename + std::string("1.cps"); pDataModel->saveModel(saveFilename, NULL, true); pMCATask->getReport().setReportDefinition(pReport); pMCATask->getReport().setTarget(pOutputFilename + std::string(".res")); pMCATask->getReport().setAppend(false); // save the file for control purposes saveFilename = pOutputFilename + std::string(".cps"); pDataModel->saveModel(saveFilename, NULL, true); // Run the task // create another report that will write to the directory where the input file came from // this can be used for debugging // create a trajectory task //pSSTask->getReport().setTarget(pOutputFilename); pMCATask->initialize(CCopasiTask::OUTPUT_SE, pDataModel, NULL); pMCATask->process(true); pDataModel->finish(); pMCATask->restore(); //status output //CSteadyStateMethod::ReturnCode rc = pSSTask->getResult(); std::string resultCode; /* switch (rc) { case CSteadyStateMethod::notFound: resultCode = "###0 No steady state found."; break; case CSteadyStateMethod::found: resultCode = "###1 Steady state found."; break; case CSteadyStateMethod::foundEquilibrium: resultCode = "###2 Equilibrium found."; break; case CSteadyStateMethod::foundNegative: resultCode = "###3 Negative steady state found."; break; } std::cout << resultCode << std::endl; */ std::string resultFileName = pOutputFilename + std::string(".txt"); std::ofstream resultFile(resultFileName.c_str()); resultFile << resultCode << std::endl; resultFile.close(); //write method log to separate file //std::string methodlog = dynamic_cast(pSSTask->getMethod())->getMethodLog(); //std::string logname = pOutputFilename + std::string(".log"); //std::ofstream ofs(logname.c_str()); //ofs << methodlog; //ofs.close(); } catch (CCopasiException Exception) { std::cerr << Exception.getMessage().getText() << std::endl; } std::string Text = ""; while (CCopasiMessage::size() > 0) { const CCopasiMessage& message = CCopasiMessage::getLastMessage(); if (message.getType() < CCopasiMessage::RAW_FILTERED) { if (Text != "") Text += "\n"; Text += message.getText(); } } if (Text != "") std::cerr << Text << std::endl; //finish CRootContainer::destroy(); return 0; }