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| <div class="section level1"> | |
| <div class="page-header"><h1 id="id_--the-copasi-r-connector"> | |
| <img src="reference/figures/logo.png" alt="CoRC logo" width="200"> — the <b>CO</b>PASI <b>R</b> <b>C</b>onnector<a class="anchor" aria-label="anchor" href="#id_--the-copasi-r-connector"></a> | |
| </h1></div> | |
| <div class="section level2"> | |
| <h2 id="overview">Overview<a class="anchor" aria-label="anchor" href="#overview"></a> | |
| </h2> | |
| <p>Development Stage: <strong>Beta</strong></p> | |
| <p>CoRC, the COPASI R Connector, links the Complex Pathway Simulator COPASI (<a href="http://copasi.org" class="external-link">copasi.org</a>) and the (statistical) programming environment R (<a href="http://r-project.org" class="external-link">r-project.org</a>). It provides easy access to the powerful biochemical model editing, simulation and analysis backend of COPASI from the convenient R command line interface. This allows the user to develop elaborate scripts and workflows for analyses that would require a great deal of tedious manual work otherwise. These scripts can then be run interactively from the R command line interface or be sent to cluster or cloud facilities for more demanding calculations.</p> | |
| <p>CoRC features:</p> | |
| <ul> | |
| <li>high-level API for COPASI in the R language.</li> | |
| <li>Immediate access to R’s data analysis capabilities and publication-ready plotting.</li> | |
| <li>Reproducible workflows from data generation to analysis and plotting (R scripts and notebooks).</li> | |
| <li>Rule-based modification of model structure to test structural variations or create large models.</li> | |
| <li>Scaling up assays, e.g. from 3 models to 3000.</li> | |
| <li>Handling of multiple models at once.</li> | |
| <li>Parallelization on multi-core machines or computing clusters.</li> | |
| </ul> | |
| <p>It is currently based on COPASI version 4.39 Build (272) and aims to closely follow COPASI releases in the future.</p> | |
| <p>CoRC comes with the Artistic License 2.0. By using CoRC you agree to this license.</p> | |
| </div> | |
| <div class="section level2"> | |
| <h2 id="installation">Installation<a class="anchor" aria-label="anchor" href="#installation"></a> | |
| </h2> | |
| <p>Install the CoRC package directly from GitHub:</p> | |
| <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> | |
| <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/install.packages.html" class="external-link">install.packages</a></span><span class="op">(</span><span class="st">"remotes"</span><span class="op">)</span></span> | |
| <span><span class="fu">remotes</span><span class="fu">::</span><span class="fu"><a href="https://remotes.r-lib.org/reference/install_github.html" class="external-link">install_github</a></span><span class="op">(</span><span class="st">"jpahle/CoRC"</span><span class="op">)</span></span></code></pre></div> | |
| <p>The installation may take a few minutes.</p> | |
| <p>CoRC runs it’s own version of the COPASI backend which it will download for your platform during installation.</p> | |
| </div> | |
| <div class="section level2"> | |
| <h2 id="usage">Usage<a class="anchor" aria-label="anchor" href="#usage"></a> | |
| </h2> | |
| <div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> | |
| <code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/jpahle/CoRC" class="external-link">CoRC</a></span><span class="op">)</span></span> | |
| <span><span class="fu"><a href="reference/loadExamples.html">loadExamples</a></span><span class="op">(</span><span class="fl">1</span><span class="op">)</span></span> | |
| <span><span class="co">#> [[1]]</span></span> | |
| <span><span class="co">#> # A COPASI model reference:</span></span> | |
| <span><span class="co">#> Model name: "The Brusselator"</span></span> | |
| <span><span class="co">#> Number of compartments: 1</span></span> | |
| <span><span class="co">#> Number of species: 6</span></span> | |
| <span><span class="co">#> Number of reactions: 4</span></span> | |
| <span></span> | |
| <span><span class="fu"><a href="reference/runTimeCourse.html">runTimeCourse</a></span><span class="op">(</span><span class="op">)</span><span class="op">$</span><span class="va">result</span></span> | |
| <span><span class="co">#> # A tibble: 201 × 3</span></span> | |
| <span><span class="co">#> Time X Y</span></span> | |
| <span><span class="co">#> <dbl> <dbl> <dbl></span></span> | |
| <span><span class="co">#> 1 0 3 3 </span></span> | |
| <span><span class="co">#> 2 0.5 3.41 0.817</span></span> | |
| <span><span class="co">#> 3 1 1.90 1.28 </span></span> | |
| <span><span class="co">#> 4 1.5 0.876 1.87 </span></span> | |
| <span><span class="co">#> 5 2 0.346 2.37 </span></span> | |
| <span><span class="co">#> 6 2.5 0.183 2.66 </span></span> | |
| <span><span class="co">#> 7 3 0.147 2.86 </span></span> | |
| <span><span class="co">#> 8 3.5 0.141 3.05 </span></span> | |
| <span><span class="co">#> 9 4 0.141 3.23 </span></span> | |
| <span><span class="co">#> 10 4.5 0.142 3.41 </span></span> | |
| <span><span class="co">#> # … with 191 more rows</span></span></code></pre></div> | |
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| <h2 data-toc-skip>Links</h2> | |
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| <li><a href="https://github.com/jpahle/CoRC/" class="external-link">Browse source code</a></li> | |
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| <h2 data-toc-skip>Citation</h2> | |
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| <li><a href="authors.html#citation">Citing CoRC</a></li> | |
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| <h2 data-toc-skip>Developers</h2> | |
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| <li>Jonas Förster <br><small class="roles"> Author, maintainer </small> </li> | |
| <li>Jürgen Pahle <br><small class="roles"> Author </small> </li> | |
| </ul> | |
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| <p>Developed by Jonas Förster, Jürgen Pahle.</p> | |
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