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| <notes> |
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| <div class="dc:title">Kummer2000 - Oscillations in Calcium |
| Signalling</div> |
| <div class="dc:description"> |
| <p>Simplified (3-variable) calcium oscillation model Kummer et |
| al. (2000) Biophys. J. 79, 1188-1195 This model is defined in a |
| small compartment with low concentrations. You can run it first |
| with the LSODA ODE solver and then with the Gillespie Monte Carlo |
| method (in Time Course widget). This illustrates that at low |
| particle numbers, as here, the stochastic simulation and the ODE |
| approach produce different results (the stochastic approach is |
| more correct in these circumstances). This file also demonstrates |
| the use of several different plots to visualize results, |
| including a histogram.</p> |
| </div> |
| <div class="dc:bibliographicCitation"> |
| <p>This model is described in the article:</p> |
| <div class="bibo:title"> |
| <a href="http://identifiers.org/pubmed/10968983" title="Access to this publication">Switching from simple to |
| complex oscillations in calcium signaling.</a> |
| </div> |
| <div class="bibo:authorList">Kummer U, Olsen LF, Dixon CJ, Green |
| AK, Bornberg-Bauer E, Baier G.</div> |
| <div class="bibo:Journal">Biophys. J. 2000 Sep; 79(3): |
| 1188-1195</div> |
| <p>Abstract:</p> |
| <div class="bibo:abstract"> |
| <p>We present a new model for calcium oscillations based on |
| experiments in hepatocytes. The model considers feedback |
| inhibition on the initial agonist receptor complex by calcium |
| and activated phospholipase C, as well as receptor |
| type-dependent self-enhanced behavior of the activated G(alpha) |
| subunit. It is able to show simple periodic oscillations and |
| periodic bursting, and it is the first model to display chaotic |
| bursting in response to agonist stimulations. Moreover, our |
| model offers a possible explanation for the differences in |
| dynamic behavior observed in response to different agonists in |
| hepatocytes.</p> |
| </div> |
| </div> |
| <div class="dc:publisher"> |
| <p>This model is hosted on |
| <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> |
| and identified by: |
| <a href="http://identifiers.org/biomodels.db/BIOMD0000000329">BIOMD0000000329</a>.</p> |
| <p>To cite BioModels Database, please use: |
| <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: |
| An enhanced, curated and annotated resource for published |
| quantitative kinetic models</a>.</p> |
| </div> |
| <div class="dc:license"> |
| <p>To the extent possible under law, all copyright and related or |
| neighbouring rights to this encoded model have been dedicated to |
| the public domain worldwide. Please refer to |
| <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 |
| Public Domain Dedication</a> for more information.</p> |
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| <kineticLaw metaid="d4b41554-0f73-4c14-bfc8-d698060a20b8"> |
| <math xmlns="http://www.w3.org/1998/Math/MathML"> |
| <apply> |
| <times/> |
| <ci> compartment </ci> |
| <apply> |
| <ci> Henri_Michaelis_Menten__irreversible </ci> |
| <ci> c </ci> |
| <ci> Km </ci> |
| <ci> V </ci> |
| </apply> |
| </apply> |
| </math> |
| <listOfParameters> |
| <parameter id="Km" metaid="_9bf8eb85-21ce-4fd5-9db4-0756dba4f98c" name="Km" value="0.16"/> |
| <parameter id="V" metaid="a7cccc64-a1ae-485a-bad1-46a4b1b333e4" name="V" value="153"/> |
| </listOfParameters> |
| </kineticLaw> |
| </reaction> |
| </listOfReactions> |
| </model> |
| </sbml> |
|
|
