Datasets:
Add v5/evaluation/consensus_biomarker_panel.json
Browse files
v5/evaluation/consensus_biomarker_panel.json
ADDED
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@@ -0,0 +1,892 @@
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| 1 |
+
{
|
| 2 |
+
"panel_size": 20,
|
| 3 |
+
"n_candidates_scored": 1919,
|
| 4 |
+
"max_possible_score": 12,
|
| 5 |
+
"panel": [
|
| 6 |
+
{
|
| 7 |
+
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|
| 8 |
+
"gene": "MUP22",
|
| 9 |
+
"human_symbol": "MUP22",
|
| 10 |
+
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|
| 11 |
+
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|
| 12 |
+
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|
| 13 |
+
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|
| 14 |
+
},
|
| 15 |
+
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|
| 16 |
+
"colon",
|
| 17 |
+
"gastrocnemius",
|
| 18 |
+
"lung",
|
| 19 |
+
"skin"
|
| 20 |
+
],
|
| 21 |
+
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|
| 22 |
+
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|
| 23 |
+
},
|
| 24 |
+
{
|
| 25 |
+
"rank": 2,
|
| 26 |
+
"gene": "Thrsp",
|
| 27 |
+
"human_symbol": "THRSP",
|
| 28 |
+
"score": 5,
|
| 29 |
+
"sources": {
|
| 30 |
+
"shap": 1,
|
| 31 |
+
"wgcna_hub": 1,
|
| 32 |
+
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|
| 33 |
+
"druggable": 1
|
| 34 |
+
},
|
| 35 |
+
"tissues": [
|
| 36 |
+
"colon",
|
| 37 |
+
"kidney",
|
| 38 |
+
"lung",
|
| 39 |
+
"skin"
|
| 40 |
+
],
|
| 41 |
+
"n_tissues": 4,
|
| 42 |
+
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|
| 43 |
+
{
|
| 44 |
+
"drug": "LIOTHYRONINE",
|
| 45 |
+
"tier": "tier1_approved",
|
| 46 |
+
"source": "DGIdb"
|
| 47 |
+
},
|
| 48 |
+
{
|
| 49 |
+
"drug": "STREPTOZOCIN",
|
| 50 |
+
"tier": "tier1_approved",
|
| 51 |
+
"source": "DGIdb"
|
| 52 |
+
},
|
| 53 |
+
{
|
| 54 |
+
"drug": "DEXAMETHASONE",
|
| 55 |
+
"tier": "tier1_approved",
|
| 56 |
+
"source": "DGIdb"
|
| 57 |
+
}
|
| 58 |
+
]
|
| 59 |
+
},
|
| 60 |
+
{
|
| 61 |
+
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|
| 62 |
+
"gene": "Apoa1",
|
| 63 |
+
"human_symbol": "APOA1",
|
| 64 |
+
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|
| 65 |
+
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|
| 66 |
+
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|
| 67 |
+
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|
| 68 |
+
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|
| 69 |
+
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|
| 70 |
+
},
|
| 71 |
+
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|
| 72 |
+
"colon",
|
| 73 |
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"gastrocnemius",
|
| 74 |
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"skin",
|
| 75 |
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"thymus"
|
| 76 |
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],
|
| 77 |
+
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|
| 78 |
+
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|
| 79 |
+
{
|
| 80 |
+
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|
| 81 |
+
"tier": "tier1_approved",
|
| 82 |
+
"source": "DGIdb"
|
| 83 |
+
},
|
| 84 |
+
{
|
| 85 |
+
"drug": "GLUCAGON (RDNA)",
|
| 86 |
+
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|
| 87 |
+
"source": "DGIdb"
|
| 88 |
+
},
|
| 89 |
+
{
|
| 90 |
+
"drug": "DEHYDRATED ALCOHOL",
|
| 91 |
+
"tier": "tier1_approved",
|
| 92 |
+
"source": "DGIdb"
|
| 93 |
+
},
|
| 94 |
+
{
|
| 95 |
+
"drug": "TRETINOIN",
|
| 96 |
+
"tier": "tier1_approved",
|
| 97 |
+
"source": "DGIdb"
|
| 98 |
+
},
|
| 99 |
+
{
|
| 100 |
+
"drug": "FUROSEMIDE",
|
| 101 |
+
"tier": "tier1_approved",
|
| 102 |
+
"source": "DGIdb"
|
| 103 |
+
},
|
| 104 |
+
{
|
| 105 |
+
"drug": "LAMIVUDINE",
|
| 106 |
+
"tier": "tier1_approved",
|
| 107 |
+
"source": "DGIdb"
|
| 108 |
+
},
|
| 109 |
+
{
|
| 110 |
+
"drug": "PROGESTIN",
|
| 111 |
+
"tier": "tier1_approved",
|
| 112 |
+
"source": "DGIdb"
|
| 113 |
+
}
|
| 114 |
+
]
|
| 115 |
+
},
|
| 116 |
+
{
|
| 117 |
+
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|
| 118 |
+
"gene": "THRSP",
|
| 119 |
+
"human_symbol": "THRSP",
|
| 120 |
+
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|
| 121 |
+
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|
| 122 |
+
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|
| 123 |
+
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|
| 124 |
+
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|
| 125 |
+
},
|
| 126 |
+
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|
| 127 |
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"colon",
|
| 128 |
+
"lung",
|
| 129 |
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"skin"
|
| 130 |
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],
|
| 131 |
+
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|
| 132 |
+
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|
| 133 |
+
{
|
| 134 |
+
"drug": "LIOTHYRONINE",
|
| 135 |
+
"tier": "tier1_approved",
|
| 136 |
+
"source": "DGIdb"
|
| 137 |
+
},
|
| 138 |
+
{
|
| 139 |
+
"drug": "STREPTOZOCIN",
|
| 140 |
+
"tier": "tier1_approved",
|
| 141 |
+
"source": "DGIdb"
|
| 142 |
+
},
|
| 143 |
+
{
|
| 144 |
+
"drug": "DEXAMETHASONE",
|
| 145 |
+
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|
| 146 |
+
"source": "DGIdb"
|
| 147 |
+
}
|
| 148 |
+
]
|
| 149 |
+
},
|
| 150 |
+
{
|
| 151 |
+
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|
| 152 |
+
"gene": "Top2a",
|
| 153 |
+
"human_symbol": "TOP2A",
|
| 154 |
+
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|
| 155 |
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|
| 156 |
+
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|
| 157 |
+
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|
| 158 |
+
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|
| 159 |
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|
| 160 |
+
},
|
| 161 |
+
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|
| 162 |
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"eye",
|
| 163 |
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"kidney",
|
| 164 |
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"thymus"
|
| 165 |
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],
|
| 166 |
+
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|
| 167 |
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|
| 168 |
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{
|
| 169 |
+
"drug": "DIGITOXIN",
|
| 170 |
+
"tier": "tier1_approved",
|
| 171 |
+
"source": "DGIdb"
|
| 172 |
+
},
|
| 173 |
+
{
|
| 174 |
+
"drug": "EPIRUBICIN",
|
| 175 |
+
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|
| 176 |
+
"source": "DGIdb"
|
| 177 |
+
},
|
| 178 |
+
{
|
| 179 |
+
"drug": "PEFLOXACIN",
|
| 180 |
+
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|
| 181 |
+
"source": "DGIdb"
|
| 182 |
+
},
|
| 183 |
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{
|
| 184 |
+
"drug": "IDARUBICIN",
|
| 185 |
+
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|
| 186 |
+
"source": "DGIdb"
|
| 187 |
+
},
|
| 188 |
+
{
|
| 189 |
+
"drug": "GENISTEIN",
|
| 190 |
+
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|
| 191 |
+
"source": "DGIdb"
|
| 192 |
+
},
|
| 193 |
+
{
|
| 194 |
+
"drug": "DOXORUBICIN HYDROCHLORIDE",
|
| 195 |
+
"tier": "tier1_approved",
|
| 196 |
+
"source": "DGIdb"
|
| 197 |
+
},
|
| 198 |
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{
|
| 199 |
+
"drug": "DAUNORUBICIN LIPOSOMAL",
|
| 200 |
+
"tier": "tier1_approved",
|
| 201 |
+
"source": "DGIdb"
|
| 202 |
+
},
|
| 203 |
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{
|
| 204 |
+
"drug": "CAMPTOTHECIN",
|
| 205 |
+
"tier": "tier1_approved",
|
| 206 |
+
"source": "DGIdb"
|
| 207 |
+
},
|
| 208 |
+
{
|
| 209 |
+
"drug": "TENIPOSIDE",
|
| 210 |
+
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|
| 211 |
+
"source": "DGIdb"
|
| 212 |
+
},
|
| 213 |
+
{
|
| 214 |
+
"drug": "DEXRAZOXANE",
|
| 215 |
+
"tier": "tier1_approved",
|
| 216 |
+
"source": "DGIdb"
|
| 217 |
+
},
|
| 218 |
+
{
|
| 219 |
+
"drug": "ETOPOSIDE",
|
| 220 |
+
"tier": "tier1_approved",
|
| 221 |
+
"source": "DGIdb"
|
| 222 |
+
},
|
| 223 |
+
{
|
| 224 |
+
"drug": "DACTINOMYCIN",
|
| 225 |
+
"tier": "tier1_approved",
|
| 226 |
+
"source": "DGIdb"
|
| 227 |
+
},
|
| 228 |
+
{
|
| 229 |
+
"drug": "PODOFILOX",
|
| 230 |
+
"tier": "tier1_approved",
|
| 231 |
+
"source": "DGIdb"
|
| 232 |
+
},
|
| 233 |
+
{
|
| 234 |
+
"drug": "FLUOROURACIL",
|
| 235 |
+
"tier": "tier1_approved",
|
| 236 |
+
"source": "DGIdb"
|
| 237 |
+
},
|
| 238 |
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{
|
| 239 |
+
"drug": "PIXANTRONE",
|
| 240 |
+
"tier": "tier1_approved",
|
| 241 |
+
"source": "DGIdb"
|
| 242 |
+
},
|
| 243 |
+
{
|
| 244 |
+
"drug": "DAUNORUBICIN CITRATE",
|
| 245 |
+
"tier": "tier1_approved",
|
| 246 |
+
"source": "DGIdb"
|
| 247 |
+
},
|
| 248 |
+
{
|
| 249 |
+
"drug": "ETOPOSIDE PHOSPHATE",
|
| 250 |
+
"tier": "tier1_approved",
|
| 251 |
+
"source": "DGIdb"
|
| 252 |
+
},
|
| 253 |
+
{
|
| 254 |
+
"drug": "DEXRAZOXANE HYDROCHLORIDE",
|
| 255 |
+
"tier": "tier1_approved",
|
| 256 |
+
"source": "DGIdb"
|
| 257 |
+
},
|
| 258 |
+
{
|
| 259 |
+
"drug": "AMSACRINE",
|
| 260 |
+
"tier": "tier1_approved",
|
| 261 |
+
"source": "DGIdb"
|
| 262 |
+
},
|
| 263 |
+
{
|
| 264 |
+
"drug": "HYDROQUINONE",
|
| 265 |
+
"tier": "tier1_approved",
|
| 266 |
+
"source": "DGIdb"
|
| 267 |
+
},
|
| 268 |
+
{
|
| 269 |
+
"drug": "ENOXACIN",
|
| 270 |
+
"tier": "tier1_approved",
|
| 271 |
+
"source": "DGIdb"
|
| 272 |
+
},
|
| 273 |
+
{
|
| 274 |
+
"drug": "VINCRISTINE",
|
| 275 |
+
"tier": "tier1_approved",
|
| 276 |
+
"source": "DGIdb"
|
| 277 |
+
},
|
| 278 |
+
{
|
| 279 |
+
"drug": "CINOXACIN",
|
| 280 |
+
"tier": "tier1_approved",
|
| 281 |
+
"source": "DGIdb"
|
| 282 |
+
},
|
| 283 |
+
{
|
| 284 |
+
"drug": "QUERCETIN",
|
| 285 |
+
"tier": "tier1_approved",
|
| 286 |
+
"source": "DGIdb"
|
| 287 |
+
},
|
| 288 |
+
{
|
| 289 |
+
"drug": "MITOXANTRONE HYDROCHLORIDE",
|
| 290 |
+
"tier": "tier1_approved",
|
| 291 |
+
"source": "DGIdb"
|
| 292 |
+
},
|
| 293 |
+
{
|
| 294 |
+
"drug": "NALIDIXIC ACID",
|
| 295 |
+
"tier": "tier1_approved",
|
| 296 |
+
"source": "DGIdb"
|
| 297 |
+
},
|
| 298 |
+
{
|
| 299 |
+
"drug": "DAUNORUBICIN HYDROCHLORIDE",
|
| 300 |
+
"tier": "tier1_approved",
|
| 301 |
+
"source": "DGIdb"
|
| 302 |
+
},
|
| 303 |
+
{
|
| 304 |
+
"drug": "MITOXANTRONE",
|
| 305 |
+
"tier": "tier1_approved",
|
| 306 |
+
"source": "DGIdb"
|
| 307 |
+
},
|
| 308 |
+
{
|
| 309 |
+
"drug": "VALRUBICIN",
|
| 310 |
+
"tier": "tier1_approved",
|
| 311 |
+
"source": "DGIdb"
|
| 312 |
+
},
|
| 313 |
+
{
|
| 314 |
+
"drug": "PACLITAXEL",
|
| 315 |
+
"tier": "tier1_approved",
|
| 316 |
+
"source": "DGIdb"
|
| 317 |
+
}
|
| 318 |
+
]
|
| 319 |
+
},
|
| 320 |
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{
|
| 321 |
+
"rank": 6,
|
| 322 |
+
"gene": "Serpina6",
|
| 323 |
+
"human_symbol": "SERPINA6",
|
| 324 |
+
"score": 5,
|
| 325 |
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"sources": {
|
| 326 |
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"shap": 1,
|
| 327 |
+
"wgcna_hub": 2,
|
| 328 |
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|
| 329 |
+
"druggable": 1
|
| 330 |
+
},
|
| 331 |
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"tissues": [
|
| 332 |
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"colon",
|
| 333 |
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"thymus"
|
| 334 |
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],
|
| 335 |
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|
| 336 |
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|
| 337 |
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{
|
| 338 |
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"drug": "CICLESONIDE",
|
| 339 |
+
"tier": "tier1_approved",
|
| 340 |
+
"source": "DGIdb"
|
| 341 |
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},
|
| 342 |
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{
|
| 343 |
+
"drug": "ALCLOMETASONE",
|
| 344 |
+
"tier": "tier1_approved",
|
| 345 |
+
"source": "DGIdb"
|
| 346 |
+
},
|
| 347 |
+
{
|
| 348 |
+
"drug": "RIMEXOLONE",
|
| 349 |
+
"tier": "tier1_approved",
|
| 350 |
+
"source": "DGIdb"
|
| 351 |
+
},
|
| 352 |
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{
|
| 353 |
+
"drug": "DOXORUBICIN HYDROCHLORIDE",
|
| 354 |
+
"tier": "tier1_approved",
|
| 355 |
+
"source": "DGIdb"
|
| 356 |
+
},
|
| 357 |
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{
|
| 358 |
+
"drug": "PARAMETHASONE",
|
| 359 |
+
"tier": "tier1_approved",
|
| 360 |
+
"source": "DGIdb"
|
| 361 |
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},
|
| 362 |
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{
|
| 363 |
+
"drug": "DAUNORUBICIN LIPOSOMAL",
|
| 364 |
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"tier": "tier1_approved",
|
| 365 |
+
"source": "DGIdb"
|
| 366 |
+
},
|
| 367 |
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{
|
| 368 |
+
"drug": "TRIAMCINOLONE",
|
| 369 |
+
"tier": "tier1_approved",
|
| 370 |
+
"source": "DGIdb"
|
| 371 |
+
},
|
| 372 |
+
{
|
| 373 |
+
"drug": "BECLOMETHASONE",
|
| 374 |
+
"tier": "tier1_approved",
|
| 375 |
+
"source": "DGIdb"
|
| 376 |
+
}
|
| 377 |
+
]
|
| 378 |
+
},
|
| 379 |
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{
|
| 380 |
+
"rank": 7,
|
| 381 |
+
"gene": "Tnnc1",
|
| 382 |
+
"human_symbol": "TNNC1",
|
| 383 |
+
"score": 5,
|
| 384 |
+
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|
| 385 |
+
"shap": 1,
|
| 386 |
+
"wgcna_hub": 2,
|
| 387 |
+
"multi_tissue": 1,
|
| 388 |
+
"druggable": 1
|
| 389 |
+
},
|
| 390 |
+
"tissues": [
|
| 391 |
+
"gastrocnemius",
|
| 392 |
+
"skin"
|
| 393 |
+
],
|
| 394 |
+
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|
| 395 |
+
"drugs": [
|
| 396 |
+
{
|
| 397 |
+
"drug": "BEPRIDIL",
|
| 398 |
+
"tier": "tier1_approved",
|
| 399 |
+
"source": "DGIdb"
|
| 400 |
+
},
|
| 401 |
+
{
|
| 402 |
+
"drug": "LEVOSIMENDAN",
|
| 403 |
+
"tier": "tier1_approved",
|
| 404 |
+
"source": "DGIdb"
|
| 405 |
+
}
|
| 406 |
+
]
|
| 407 |
+
},
|
| 408 |
+
{
|
| 409 |
+
"rank": 8,
|
| 410 |
+
"gene": "Myh7",
|
| 411 |
+
"human_symbol": "MYH7",
|
| 412 |
+
"score": 5,
|
| 413 |
+
"sources": {
|
| 414 |
+
"shap": 1,
|
| 415 |
+
"wgcna_hub": 2,
|
| 416 |
+
"multi_tissue": 1,
|
| 417 |
+
"druggable": 1
|
| 418 |
+
},
|
| 419 |
+
"tissues": [
|
| 420 |
+
"gastrocnemius",
|
| 421 |
+
"skin"
|
| 422 |
+
],
|
| 423 |
+
"n_tissues": 2,
|
| 424 |
+
"drugs": [
|
| 425 |
+
{
|
| 426 |
+
"drug": "MAVACAMTEN",
|
| 427 |
+
"tier": "tier1_approved",
|
| 428 |
+
"source": "DGIdb"
|
| 429 |
+
}
|
| 430 |
+
]
|
| 431 |
+
},
|
| 432 |
+
{
|
| 433 |
+
"rank": 9,
|
| 434 |
+
"gene": "Ddit4",
|
| 435 |
+
"human_symbol": "DDIT4",
|
| 436 |
+
"score": 5,
|
| 437 |
+
"sources": {
|
| 438 |
+
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|
| 439 |
+
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|
| 440 |
+
"literature": 2
|
| 441 |
+
},
|
| 442 |
+
"tissues": [
|
| 443 |
+
"gastrocnemius"
|
| 444 |
+
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| 445 |
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| 446 |
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| 447 |
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|
| 448 |
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|
| 449 |
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|
| 450 |
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|
| 451 |
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},
|
| 452 |
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{
|
| 453 |
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|
| 454 |
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|
| 455 |
+
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|
| 456 |
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},
|
| 457 |
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{
|
| 458 |
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|
| 459 |
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|
| 460 |
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|
| 461 |
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},
|
| 462 |
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{
|
| 463 |
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|
| 464 |
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|
| 465 |
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|
| 466 |
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},
|
| 467 |
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{
|
| 468 |
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|
| 469 |
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|
| 470 |
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|
| 471 |
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},
|
| 472 |
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{
|
| 473 |
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"drug": "AMITRIPTYLINE HYDROCHLORIDE",
|
| 474 |
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|
| 475 |
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|
| 476 |
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}
|
| 477 |
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|
| 478 |
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},
|
| 479 |
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{
|
| 480 |
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|
| 481 |
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|
| 482 |
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| 483 |
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| 484 |
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| 485 |
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| 486 |
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| 487 |
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| 488 |
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| 489 |
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| 490 |
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| 491 |
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| 492 |
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| 493 |
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| 494 |
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| 495 |
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| 496 |
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| 497 |
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{
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| 498 |
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|
| 499 |
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|
| 500 |
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| 501 |
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| 502 |
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| 503 |
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| 504 |
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| 505 |
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| 506 |
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| 507 |
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| 508 |
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| 509 |
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| 510 |
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| 511 |
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| 512 |
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| 513 |
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| 514 |
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| 515 |
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{
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| 516 |
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| 517 |
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| 518 |
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| 519 |
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| 520 |
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| 521 |
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| 522 |
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| 523 |
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| 524 |
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| 525 |
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| 526 |
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| 527 |
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| 528 |
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| 529 |
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| 530 |
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| 531 |
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| 532 |
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{
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| 533 |
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|
| 534 |
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|
| 535 |
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| 536 |
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| 537 |
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| 538 |
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| 539 |
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| 540 |
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| 541 |
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| 542 |
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| 543 |
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| 544 |
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| 545 |
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| 546 |
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| 547 |
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| 548 |
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| 549 |
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| 550 |
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{
|
| 551 |
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|
| 552 |
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"gene": "Cfd",
|
| 553 |
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| 554 |
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| 555 |
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| 556 |
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| 557 |
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| 558 |
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| 559 |
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| 560 |
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| 561 |
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| 562 |
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| 563 |
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| 564 |
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| 565 |
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| 566 |
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| 567 |
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| 568 |
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{
|
| 569 |
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"drug": "DANICOPAN",
|
| 570 |
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|
| 571 |
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|
| 572 |
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}
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| 573 |
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]
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| 574 |
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},
|
| 575 |
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{
|
| 576 |
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| 577 |
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|
| 578 |
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| 579 |
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| 580 |
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| 581 |
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| 582 |
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| 583 |
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| 584 |
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| 585 |
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| 586 |
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| 587 |
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| 588 |
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| 589 |
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| 590 |
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| 591 |
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| 592 |
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|
| 593 |
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|
| 594 |
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|
| 595 |
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|
| 596 |
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}
|
| 597 |
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]
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| 598 |
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},
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| 599 |
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{
|
| 600 |
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| 601 |
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| 602 |
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| 603 |
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| 604 |
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| 605 |
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| 606 |
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| 607 |
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| 608 |
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| 609 |
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| 610 |
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| 611 |
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| 612 |
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| 613 |
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| 614 |
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| 615 |
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| 616 |
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{
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| 617 |
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|
| 618 |
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| 619 |
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| 620 |
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| 621 |
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| 622 |
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| 623 |
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| 624 |
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| 625 |
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| 626 |
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| 627 |
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| 628 |
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| 629 |
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| 630 |
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| 631 |
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| 632 |
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| 633 |
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{
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| 634 |
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| 635 |
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|
| 636 |
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| 637 |
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| 638 |
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| 639 |
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| 640 |
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| 641 |
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| 642 |
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| 643 |
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| 644 |
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| 645 |
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| 646 |
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| 647 |
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| 648 |
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| 649 |
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| 650 |
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{
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| 651 |
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| 652 |
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"gene": "Snora70",
|
| 653 |
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|
| 654 |
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| 655 |
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| 656 |
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| 657 |
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| 658 |
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| 659 |
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| 660 |
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| 661 |
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| 662 |
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| 663 |
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| 664 |
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| 665 |
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| 666 |
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| 667 |
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{
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| 668 |
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|
| 669 |
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|
| 670 |
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|
| 671 |
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| 672 |
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| 673 |
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| 674 |
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| 675 |
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| 676 |
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| 677 |
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| 678 |
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| 679 |
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| 680 |
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| 681 |
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| 682 |
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| 683 |
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}
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| 684 |
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],
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| 685 |
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| 686 |
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| 687 |
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| 688 |
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| 689 |
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|
| 690 |
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| 691 |
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| 692 |
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| 693 |
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|
| 694 |
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},
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| 695 |
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| 696 |
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"liver": {
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| 697 |
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| 698 |
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| 699 |
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| 700 |
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| 701 |
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| 702 |
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|
| 703 |
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"Ddit4",
|
| 704 |
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"Top2a",
|
| 705 |
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"Lrrc14b",
|
| 706 |
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"Ms4a4c",
|
| 707 |
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"Myoz2",
|
| 708 |
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"Apoa1",
|
| 709 |
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"Thrsp",
|
| 710 |
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"Myh7",
|
| 711 |
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"Rpl36",
|
| 712 |
+
"Serpina6",
|
| 713 |
+
"H4c8",
|
| 714 |
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"Cfd",
|
| 715 |
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"Tnnc1",
|
| 716 |
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"Snora70",
|
| 717 |
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"Snora70"
|
| 718 |
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]
|
| 719 |
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},
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| 720 |
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| 721 |
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| 722 |
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| 723 |
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| 724 |
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| 725 |
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| 726 |
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"Retn",
|
| 727 |
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"Ddit4",
|
| 728 |
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"Top2a",
|
| 729 |
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"Lrrc14b",
|
| 730 |
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"Myoz2",
|
| 731 |
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"Apoa1",
|
| 732 |
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"Thrsp",
|
| 733 |
+
"Myh7",
|
| 734 |
+
"Rpl36",
|
| 735 |
+
"Serpina6",
|
| 736 |
+
"H4c8",
|
| 737 |
+
"Cfd",
|
| 738 |
+
"Tnnc1",
|
| 739 |
+
"Snora70"
|
| 740 |
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]
|
| 741 |
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},
|
| 742 |
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|
| 743 |
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|
| 744 |
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|
| 745 |
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|
| 746 |
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|
| 747 |
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|
| 748 |
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"Retn",
|
| 749 |
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"Ddit4",
|
| 750 |
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"Top2a",
|
| 751 |
+
"Lrrc14b",
|
| 752 |
+
"Ms4a4c",
|
| 753 |
+
"Myoz2",
|
| 754 |
+
"Apoa1",
|
| 755 |
+
"Thrsp",
|
| 756 |
+
"Myh7",
|
| 757 |
+
"Rpl36",
|
| 758 |
+
"Serpina6",
|
| 759 |
+
"H4c8",
|
| 760 |
+
"Cfd",
|
| 761 |
+
"Tnnc1",
|
| 762 |
+
"Snora70"
|
| 763 |
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]
|
| 764 |
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},
|
| 765 |
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"thymus": {
|
| 766 |
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|
| 767 |
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|
| 768 |
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|
| 769 |
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"n_panel_genes_found": 15,
|
| 770 |
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|
| 771 |
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"Retn",
|
| 772 |
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"Ddit4",
|
| 773 |
+
"Top2a",
|
| 774 |
+
"Lrrc14b",
|
| 775 |
+
"Ms4a4c",
|
| 776 |
+
"Myoz2",
|
| 777 |
+
"Apoa1",
|
| 778 |
+
"Thrsp",
|
| 779 |
+
"Myh7",
|
| 780 |
+
"Rpl36",
|
| 781 |
+
"Serpina6",
|
| 782 |
+
"H4c8",
|
| 783 |
+
"Cfd",
|
| 784 |
+
"Tnnc1",
|
| 785 |
+
"Snora70"
|
| 786 |
+
]
|
| 787 |
+
},
|
| 788 |
+
"eye": {
|
| 789 |
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|
| 790 |
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|
| 791 |
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|
| 792 |
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"n_panel_genes_found": 14,
|
| 793 |
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|
| 794 |
+
"Retn",
|
| 795 |
+
"Ddit4",
|
| 796 |
+
"Top2a",
|
| 797 |
+
"Lrrc14b",
|
| 798 |
+
"Ms4a4c",
|
| 799 |
+
"Myoz2",
|
| 800 |
+
"Apoa1",
|
| 801 |
+
"Thrsp",
|
| 802 |
+
"Myh7",
|
| 803 |
+
"Rpl36",
|
| 804 |
+
"H4c8",
|
| 805 |
+
"Cfd",
|
| 806 |
+
"Snora70",
|
| 807 |
+
"Tnnc1"
|
| 808 |
+
]
|
| 809 |
+
},
|
| 810 |
+
"skin": {
|
| 811 |
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"auroc": 0.6502,
|
| 812 |
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|
| 813 |
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|
| 814 |
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"n_panel_genes_found": 14,
|
| 815 |
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"panel_genes_matched": [
|
| 816 |
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"Snora70",
|
| 817 |
+
"Rpl36",
|
| 818 |
+
"Tnnc1",
|
| 819 |
+
"Retn",
|
| 820 |
+
"Thrsp",
|
| 821 |
+
"Apoa1",
|
| 822 |
+
"Ms4a4c",
|
| 823 |
+
"Top2a",
|
| 824 |
+
"Ddit4",
|
| 825 |
+
"Myh7",
|
| 826 |
+
"Myoz2",
|
| 827 |
+
"Lrrc14b",
|
| 828 |
+
"H4c8",
|
| 829 |
+
"Cfd"
|
| 830 |
+
]
|
| 831 |
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},
|
| 832 |
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"lung": {
|
| 833 |
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"auroc": 0.5955,
|
| 834 |
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|
| 835 |
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"n_folds": 5,
|
| 836 |
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"n_panel_genes_found": 15,
|
| 837 |
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"panel_genes_matched": [
|
| 838 |
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"Retn",
|
| 839 |
+
"Ddit4",
|
| 840 |
+
"Top2a",
|
| 841 |
+
"Lrrc14b",
|
| 842 |
+
"Ms4a4c",
|
| 843 |
+
"Myoz2",
|
| 844 |
+
"Apoa1",
|
| 845 |
+
"Thrsp",
|
| 846 |
+
"Myh7",
|
| 847 |
+
"Rpl36",
|
| 848 |
+
"Serpina6",
|
| 849 |
+
"H4c8",
|
| 850 |
+
"Cfd",
|
| 851 |
+
"Snora70",
|
| 852 |
+
"Tnnc1"
|
| 853 |
+
]
|
| 854 |
+
},
|
| 855 |
+
"colon": {
|
| 856 |
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|
| 857 |
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|
| 858 |
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|
| 859 |
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"n_panel_genes_found": 15,
|
| 860 |
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"panel_genes_matched": [
|
| 861 |
+
"Retn",
|
| 862 |
+
"Ddit4",
|
| 863 |
+
"Top2a",
|
| 864 |
+
"Lrrc14b",
|
| 865 |
+
"Ms4a4c",
|
| 866 |
+
"Myoz2",
|
| 867 |
+
"Apoa1",
|
| 868 |
+
"Thrsp",
|
| 869 |
+
"Myh7",
|
| 870 |
+
"Rpl36",
|
| 871 |
+
"Serpina6",
|
| 872 |
+
"H4c8",
|
| 873 |
+
"Cfd",
|
| 874 |
+
"Snora70",
|
| 875 |
+
"Tnnc1"
|
| 876 |
+
]
|
| 877 |
+
}
|
| 878 |
+
},
|
| 879 |
+
"evidence_sources": {
|
| 880 |
+
"shap_consensus": 5,
|
| 881 |
+
"shap_tissue_specific": 122,
|
| 882 |
+
"shap_any_top100": 1362,
|
| 883 |
+
"wgcna_hub_total": 540,
|
| 884 |
+
"wgcna_hub_condition": 188,
|
| 885 |
+
"ppi_hubs": 6,
|
| 886 |
+
"lr_genes": 2,
|
| 887 |
+
"fda_drug_targets": 195,
|
| 888 |
+
"clinical_drug_targets": 0,
|
| 889 |
+
"drosophila_orthologs": 0,
|
| 890 |
+
"cell2020_reference": 67
|
| 891 |
+
}
|
| 892 |
+
}
|