<div> Bovine alphaherpesvirus one (BoHV-1) is a primary cause of bovine respiratory disease (BRD), and a leading cause of morbidity and mortality in cattle. The transcriptomic responses of key respiratory and immune associated tissues of dairy calves following experimental challenge with BoHV-1 are unknown. Thus, the study objective was to examine the gene expression profiles of multiple tissue types from dairy calves following an infectious challenge with BoHV-1. Holstein-Friesian bull calves (


Introduction Male pattern hair loss (MPHL), also known as androgenetic alopecia (AGA), is a common disorder primarily caused by dihydrotestosterone (DHT). The Food and Drug Administration (FDA) has approved two 5-alpha reductase (5-AR) inhibitors—finasteride and dutasteride—for treating this condition. However, recent studies have reported adverse sexual side effects and issues with sperm production in young men using these medications. There are also recommendations for effectively treating hai


In an era of increasing cultural and religious diversity, higher education institutions worldwide are under pressure to foster inclusive environments that prepare students for pluralistic societies. This study examines how Islamic higher education in Indonesia navigates multiculturalism by analyzing three institutional cases through the lens of leadership agency, socio-religious context, and institutional culture. Drawing on document analysis, interviews, and classroom observations, the findings


<div> This study investigates the potential usage of biowaste (i.e., bagasse ash) in cementitious grouts for semi-flexible pavement applications. Cementitious grouts were prepared by partially replacing cement with bagasse ash (5%, 10%, 15% and 20%) and at w/c ratios of 0.30 to 0.40. Flow cone apparatus was used to determine the flow properties of fresh cementitious grouts. The hardened specimens of cementitious grouts also were tested for compressive strength at curing ages of 7 and 28 days. Mo


This paper explores Louis-Ferdinand Céline's 1932 Journey to the end of the night within the context of growing work on the literary geographies of modernity. The paper argues that Céline's novel can be productively aligned with other texts such as Ulysses or Heart of darkness as a way of thinking about the experiences of modernity in terms of a spatial disorientation that provokes new kinds of writing. At the same time, Céline's novel is distinctive because it presents the experience of moderni


In modern agriculture site specific irrigation (SSI) involves delivering water to a specific land location to match water application with crop water demand, in order to achieve required crop responses (e.g. in terms of yield and quality) in a cost-effective way. SSI includes the evaluation of crop status, processing the data into actionable information, and applying water accordingly. This chapter will deal with site-specific water delivery methods as they have evolved in the last few decades.


Background T2DM is a global health challenge characterized by insulin resistance and impaired glucose metabolism. Natural products, such as polysaccharides from medicinal plants, are increasingly explored for their potential in managing T2DM with fewer side effects compared to conventional drugs. Aim This review aims to comprehensively evaluate the effects of Polygonati Rhizoma Polysaccharide (PRP) on glucose and lipid metabolism in T2DM and elucidate its underlying molecular mechanisms. Introdu


The article offers an authorial reflection on the contribution of the prominent Polish-Jewish educator and physician Janusz Korczak to the development of intercultural communication between Ukrainians and Poles, as well as to the creation of shared commemorative practices that foster mutual understanding and enrichment. In light of the current Russian-Ukrainian war, the article highlights Korczak’s selfless pedagogical legacy and his deep compassion for children affected by hardship and conflict


Abstract Background The aging population has resulted in more people living longer with musculoskeletal conditions who require hip and knee replacement surgery. Lengthening waiting lists continue to be a challenge for patients and health care services. Objective This pragmatic study aimed to develop and test a digital self-management intervention (the HOPE [Help Overcome Problems Effectively] program) to better prepare patients waiting for hip and knee replacement surgery. Methods The study used


Different methodologies were adopted to evaluate neuromuscular function during the CMJ and the SJ tests. This makes difficult to compare the data. A SOP was proposed with information and guidelines related to muscles, hardware, and data processing. In this way, future studies could follow similar protocols increasing the possibility to compare the findings.


Objective The prevalence of modern contraceptive use in Ethiopia has increased in the past two decades. Despite these efforts, unmet needs for modern contraception persist, with limited knowledge on regional variations and determining factors. Method We analyzed data from the Ethiopian Demographic and Health Surveys (EDHS) from 2000, 2005, 2011, 2016, and 2019. Descriptive statistics examined regional variations and trends in modern contraceptive use among married, non-pregnant women. Multilevel


The high moisture and sugar content of ripe jackfruit often leads to spoilage and challenges in processing. This study explores the potential of dry green jackfruit flour as a solution, particularly for vegan meat applications. Fresh, mature, unripe jackfruit was processed, sliced, and dried using a Heat Pump Dryer under controlled conditions. The resulting flour was then evaluated for its nutritional attributes, including proximate composition, minerals, vitamins, amino acids, and antioxidant p


This study evaluated the efficacy of transcutaneous photodynamic therapy using blue (428 nm) LED irradiation on Staphylococcus aureus 11 in combination with a water-soluble cationic pyridyl porphyrin and optical clearing agents (OCA) in an ex vivo model. Results showed that OCA significantly enhanced photodynamic inactivation with a 61% reduction in bacterial cell counts after 15 minutes of light exposure, comparable to direct irradiation. Optical parameter analysis revealed a decrease in scatte


Orthogonal-split trees perform well, but evidence suggests oblique splits can enhance their performance. This paper explores optimizing high-dimensional $s$-sparse oblique splits from $\{(\vec{w}, \vec{w}^{\top}\boldsymbol{X}_{i}) : i\in \{1,\dots, n\}, \vec{w} \in \mathbb{R}^p, \| \vec{w} \|_{2} = 1, \| \vec{w} \|_{0} \leq s \}$ for growing oblique trees, where $ s $ is a user-defined sparsity parameter. We establish a connection between SID convergence and $s_0$-sparse oblique splits with $s_0


This study investigates how Black Americans evaluate norm-violating behavior depending on the race of the transgressor and the surrounding audience. Drawing on theories of stigma, identity, and social control, we examine whether Black respondents perceive greater harm to their group and exhibit stronger support for social sanctions when the norm violator is also Black, especially in the presence of non-Black audiences. This preregistered 2×2×2 factorial survey experiment randomizes the race of t


Introducción: La piel del recién nacido presenta características anatómicas y fisiológicas que la hacen más vulnerable a irritaciones e infecciones, siendo la dermatitis del pañal una de las afecciones más comunes. Esta condición, causada por factores como el contacto con orina y heces, genera disconfort y estrés en los neonatos. El cuidado adecuado de la piel, mediante estrategias como el uso de pañales absorbentes, limpieza adecuada y cremas barrera, es clave para prevenirla. Este estudio eval


Micro, Small, and Medium Enterprises (MSMEs) in the leather and snack processing sector in Garut Regency play an important role in the Indonesian economy, especially in creating jobs and supporting regional economic growth. However, these MSMEs face challenges such as limited market access and minimal knowledge of digital marketing and franchise business models, which impact their competitiveness. This community service program aims to empower leather and snack MSMEs by training them to utilize


Spectral data measured with a low-wavelength dispersion visible spectrometer. The entire visible range is measured simultaneously. Multiple lines-of-sight are used to measure the toroidal distribution or the poloidal cross-sectional distribution.


ABSTRACT The thesis attempts to explore, the social, economic and administrative history of QarsaMalima District of Southwest Shawa Zone of the Oromia Regional State from Italian occupation up to the separation of Soddo Dach from Qarsa Malima district. Like the inhabitants of other parts of the country, the people of the district have experienced major socio-economic and political changes by the time under review. During the period Italian occupation, the distict was one of the centres of patrio


Cultural values play a key role in the formation of national identity, the maintenance of cultural diversity and the preservation of historical memory. In the context of the armed conflict in Ukraine, caused by Russian aggression, these values are exposed to serious risks of destruction, damage and illegal export. Of particular importance in this context is the process of restitution – the return of lost or stolen cultural objects. This article analyzes the problems and prospects of the restitut


Extreme ultraviolet (EUV) and vacuum ultraviolet (VUV) spectroscopy diagnostics are applied to measure wavelength spectra including line emissions released from Ne ions ranging from low to high charge states simultaneously in a single discharge of the Ne-seeded divertor heat load reduction experiments in LHD.


El presente artículo pretende contribuir al debate sobre la minería informal, la cual ha experimentado una notable expansión en el sur andino peruano en los últimos años, y busca analizar los discursos estigmatizantes de ciertos sectores sociales y del Estado peruano, principalmente desde Lima. Después de problematizar los conceptos movilizados para pensar ese fenómeno, se buscará caracterizar a los actores sociales de la minería informal e indagar en las raíces y los impactos que viene teniendo


Let $ n\geqslant t\geqslant 1$ and $ \mathcal{A}_1, \mathcal{A}_2, \ldots, \mathcal{A}_m \subseteq 2^{[n]}$ be non-empty families. We say that they are pairwise cross $t$-intersecting if $|A_i\cap A_j|\geqslant t$ holds for any $A_i\in \mathcal{A}_i$ and $A_j\in \mathcal{A}_j$ with $i\neq j$. In the case where $m=2$ and $\mathcal{A}_1=\mathcal{A}_2$, determining the maximum size $M(n,t)$ of a non-uniform $t$-intersecting family of sets over $[n]$ was solved by Katona (1964), and enhanced by Fran


Family law holds a highly strategic position in Islamic jurisprudence as it governs the order and harmony of household life. In Indonesia, the reform of Islamic family law has become a necessity due to the continued dominance of classical fiqh interpretations, which often place women in a subordinate role. This condition has prompted efforts toward legislation that is more modern and responsive to the changing times and the values of gender equality. This study employs a library research method


Abstract Anaemia, a deficiency of hemoglobin (Hb) or red blood cells, is a global public health crisis. It is especially prevalent in low- and middle-income countries (LMICs) like India, which has one of the highest burdens. While air pollution epidemiological studies in LMICs have focused mainly on fine particulate matter (PM 2.5 ), the health risks of other pollutants and their combined effects remain largely unexplored. This study aimed to estimate the association between long-term exposure t


X-ray crystal spectrometer is mesurement for ion temperature in the plasma center of a large helical device (LHD) using Doppler broadening of a He-like resonance line of ArXVII, TiXXI, CrXXIII, or FeXXV.


We present a deep learning model for high-resolution probabilistic precipitation forecasting over an 8-hour horizon in Europe, overcoming the limitations of radar-only deep learning models with short forecast lead times. Our model efficiently integrates multiple data sources - including radar, satellite, and physics-based numerical weather prediction (NWP) - while capturing long-range interactions, resulting in accurate forecasts with robust uncertainty quantification through consistent probabil


The ability of Visual Question Answering (VQA) models to provide insightful responses to images based on their content holds the potential to completely transform machine interpretation and interaction. VQA systems face challenges due to noisy image data, making accurate question answering difficult. Several deep learning algorithms are used for predicting answers from images, but they don’t yield enough outcomes. To get over these problems, this work is suggested. In this manuscript, a visual q


The LHD Thomson scattering system measures electron temperature (Te) and density (ne) profiles of LHD plasmas along the LHD major radius at a horizontally elongated section (LHD 4O port – 4I port) at 144 spatial points with sampling rates from 10 Hz to 80 Hz.


Background
To investigate the effect of basic intermittent exotropia (IXT) on myopic shift in children during 12-month follow-up.
Methods
165 children aged 4–15 years were recruited prospectively in this study and divided into 3 groups: Group A, consisted of 64 patients with basic IXT without surgery; Group B, consisted of 51 patients 1-month after IXT-corrected surgery; and Group C, consisted of 50 patients without any form of strabismus. All patients underwent assessme


AI News 20|From Search to Structure: How ChatGPT Is Reshaping the Information Gateway examines how generative AI is fundamentally transforming the architecture of information access. For two decades, Google Search defined the dominant entry point to knowledge, built on the logic of “10 blue links.” Today, tools such as ChatGPT, Claude, and Gemini are shifting the unit of interaction from keywords + links to questions + structured answers. This white paper traces the systemic consequences of this


<div> This study aimed to investigate the impact of altitude, cold start, ambient temperatures, and driving behaviors on the Real Driving Emissions (RDE) of China VI standard light-duty gasoline vehicles. Tests were conducted on actual roads and in vehicle emission environment simulation laboratories at altitudes of 700 m, 1,300 m, 1,900 m, and 2,400 m in Yunnan. The results showed that: (1) as altitude increased, the CO emission factor exhibited a positive correlation trend, peaking at 2400 m w


Metastasis is the major cause of death from cancer (1); metastasis to the lymph nodes in breast cancer is dangerous, relatively common, and in one study ranged from 10-60% based on molecular subtype (2-4). We predict therapeutic index is intrinsically linked to differential expression which can be comprehensively and blindly determined using whole transcriptome data (5). We pioneered understanding of metastasis to the lymph nodes as an intermediate biological and anatomical counterpart to the CN


Charge eXchange Spectroscopy (CXS) system, which consists of diagnostic beam, object lens, optical fiber bundle array, spectrometer, CCD detector and controllers, to measure radial profiles of ion temperature, poloidal/toroidal plasma rotation velocities, and impurity density (carbon or helium) using charge exchange collisions between neutral beam and impurities.


肾病原性传染性支气管炎病毒 （NIBV） 是家禽育种业中的一种常见病毒。NIBV 感染可对鸡的肾脏、呼吸道和肠道造成损害，导致家禽出现咳嗽、稀便和肾脏斑点等临床症状。肠道是人体最大的免疫器官，目前关于 NIBV 引起的肠道损伤的研究报道很少。本研究旨在研究 NIBV 感染对十二指肠肠道屏障功能的影响。将 Hy-Line 棕色鸡随机分为对照组和疾病组。在 28 日龄时，疾病组雏鸡接种 NIBV SX9 10-5/0.2 mL。我们的结果表明，NIBV 感染导致十二指肠出血点，导致十二指肠 SIgA 含量增加。组织病理学观察和分析发现，绒毛高度降低，隐窝深度增加，VH/CD 显著降低。 同时，杯状细胞的数量减少了。 NIBV 感染下调物理屏障相关细胞因子 （ZO-1 、 occludin 和 claudin-1） 和化学屏障相关细胞因子 （MUC2 和 TFF3） 的表达，上调免疫屏障相关细胞因子 （IL-2 、 IL-4 、 IL-17 、 TGF-β 、 TNF-α 和 CCR7 的表达。 总之，NIBV 在十二指肠中复制，在十二指肠中引起炎症反应，破坏其物理、化学和免疫屏障，并影响正


This case observation explores how stimulant medication affected the learning and emotional regulation of a 7-year-old boy diagnosed with ADHD, Autism Spectrum Disorder (ASD), and Oppositional Defiant Disorder (ODD). Through a parent-led approach, the study compares his academic and behavioral outcomes across medicated and unmedicated days in both school and home settings. While medication reduced visible hyperactivity, it did not consistently enhance learning or emotional stability. These findi


В умовах воєнного стану та збройної агресії проти України, відповідно до положень Стратегії залучення, розвитку та утримання людського капіталу в силах оборони України на період до 2027 року [1], особливого значення набуває ефективна система збору та аналізу інформації про укомплектованість військових частин особовим складом, хід їх доукомплектування та покриття втрат.


La integración de la inteligencia artificial (IA) en la educación superior está generando transformaciones tanto en las metodologías de enseñanza como en la gestión académica. Lejos de ser una novedad puntual, la IA se ha convertido en una herramienta cada vez más presente en las aulas universitarias, utilizada tanto por el profesorado como por los estudiantes. Este trabajo ofrece una reflexión crítica sobre esta realidad, abordando aspectos históricos, como las primeras propuestas de automatiza


The learning outcomes for the topic of three-dimensional shapes in Grade V at SPF SDN 101789 Marindal I remain relatively low, as evidenced by the limited number of students achieving mastery when the learning process was still dominated by the lecture method. This condition reflects a mismatch between the expected learning objectives and the actual situation in the classroom. Therefore, this study aims to improve student learning outcomes through the implementation of the Culturally Responsive


The nature of low-impurity ferromagnetism remains a challenging problem in the solid-state community. Despite initial experiments dating back to the mid-20th century, a comprehensive theoretical explanation and reliable ab initio evaluations have remained elusive. The present research aims to bridge this gap by refining first-principle calculations by elucidating the magnetic and electronic behavior of Pd1-xMx alloys (where M = Mn, Fe, Co, Ni). Our study includes calculations of magnetic propert


The emergence of AI agents powered by large language models (LLMs) marks a pivotal shift toward the Agentic Web, a new phase of the internet defined by autonomous, goal-driven interactions. In this paradigm, agents interact directly with one another to plan, coordinate, and execute complex tasks on behalf of users. This transition from human-driven to machine-to-machine interaction allows intent to be delegated, relieving users from routine digital operations and enabling a more interactive, aut


Spectral data measured with a high-wavelength dispersion visible spectrometer. Spatial distribution measurements for a poloidal plasma cross section are performed by multiple lines-of-sights. The center wavelength can be changed depending on the purpose of the measurement.


Reaction virtual screening and discovery are fundamental challenges in chemistry and materials science, where traditional graph neural networks (GNNs) struggle to model multi-reactant interactions. In this work, we propose ChemHGNN, a hypergraph neural network (HGNN) framework that effectively captures high-order relationships in reaction networks. Unlike GNNs, which require constructing complete graphs for multi-reactant reactions, ChemHGNN naturally models multi-reactant reactions through hype


Introduction. Diabetes mellitus (DM) remains a major global health issue due to its direct consequences and complications, particularly cardiovascular complications. These complications are influenced by autonomic neuropathy, which can be assessed by Heart Rate Variability (HRV). Autonomic dysfunction is thought to impair heart function, which can potentially be predicted early by observing Global Longitudinal Strain (GLS). The relationship between HRV and GLS has not been extensively studied. T


Line integrated electron density (neL) and its profile calculated from raw data of FIR laser interferometers, FIR1, FIR2, and FIR3. Time resolution is basically 10 milli-second, and the time axis array is stored in the last, i.e. 14th channel.


Background. Modern gasoline stations face a number of challenges related to data management, inventory accounting, and customer service. Traditional accounting and management methods are often inefficient, resulting in increased time spent on processing information and an increased likelihood of errors. The lack of a centralized system for storing and processing data makes it difficult to analyze sales and manage inventory, which negatively affects the overall efficiency of the station. Creating


Abstract There has been a rise in complex gallbladder and biliary procedures performed in interventional radiology (IR) at the Northwestern Memorial Hospital (NMH) with the introduction of new equipment and techniques. These procedures often call for thoughtful decision-making and multidisciplinary collaboration. The integration of various healthcare disciplines—including transplant surgery, hepatology, gastroenterology, IR, and nursing—is vital to cutting-edge innovations and improved patient o


Purpose: This research introduces the Cold Wave Therapy device, an innovative, cost-effective, and contactless cryotherapy tool. Unlike traditional cryotherapy methods like ice or gel packs that risk frostbite and lack controlled cooling, this device ensures consistent and safe temperature management. Clinical studies involving patients with soft tissue injuries and spastic neurological conditions validated its therapeutic benefits. Relevance: Cryotherapy is widely recognized for its efficacy in


This is the first study to be undertaken among undergraduates, interns, and residents on knowledge and attitude regarding SDM in Saudi Arabia. It is important to evaluate this aspect as it will help generate baseline data about knowledge and attitude related to SDM in the region and further help establish appropriate policy and curriculum to incorporate the same. Hence the aim of the present study was to assess the knowledge and attitude of senior dental students toward shared decision-making re


Abstract Sugar apples are climacteric fruits that had a rapid deterioration due to their high respiration rate and ethylene production, making the application of postharvest technologies essential for extending their shelf life. The objective of this study was to develop an edible coating using carrageenan (CR), beeswax nanoparticle (BW) and titanium dioxide (TD) to extend the shelf life of sugar apples, using ultraviolet (UV) light, to maintain their shelf life at 15 ± 1 °C and 80 ± 1% RH for 1


Addressing the problem of poor robustness and anti-interference ability in the permanent magnet synchronous motor (PMSM) speed control system, an adaptive fractional-order sliding mode controller based on a fractional-order sliding mode disturbance observer is proposed. Firstly, a mathematical model of a PMSM is established, which combines adaptive control with fractional order sliding mode control to effectively reduce the drawbacks of traditional integer order sliding mode control and improve


This research investigates the effect of the homogenization process on the mechanical and magnetic properties of the 52Fe-28Cr-15Co-3Mo-2V alloy. The alloy was initially cast in a vacuum arc remelting (VAR) and then homogenized under vacuum at 1200°C for 10 h. X-ray diffraction (XRD) analysis confirmed that both the as-cast and homogenized samples consist of a single α phase. Nevertheless, variations in peak intensity indicated changes in grain orientation and texture. Vickers hardness measureme


We all know that each and every student has different learning and understanding abilities. Teachers might have faced difficulty making a few students understand the concepts. As educators, we have to master different types of teaching methodologies to teach different kinds of learners. We have to adopt a mixture of two-to-three teaching methodologies to teach a group of mixed students. In our research, we have taken four major kinds of learners, such as visual, auditory, reading and writing, an


Abstract Based on the life cycle assessment, experimental research was conducted on the green attribute data of the concrete pump truck. Green attribute evaluation indicators were selected for the concrete pump truck, and quantitative statistics and experimental verification were conducted. The test results indicate that the green design and manufacturing level of the concrete pump truck have not yet met the evaluation requirements for green products. The results indicate that obtaining, calcula


Введение. Общим патогенетическим событием при развитии нейродегенеративных заболеваний является агрегация специфических белков в нервной системе. Агрегация белка α-синуклеина обнаруживается при болезни Паркинсона (БП), деменции с тельцами Леви, множественной системной атрофии и др. Исходя из этого, основным направлением поиска потенциальной терапии является разработка препаратов с антиагрегационными свойствами, которые способны предотвращать образование агрегатов, либо способствовать разрушению


This scholarship challenges Ayọ̀bámi Adébáyọ̀'s novel A Spell of Good Things' trinity of gender, power, and identity, and situates its analysis within Nigerian political and social discourses and African feminist arguments today. Adébáyọ̀'s novel depicts that gender identity is not a biological immanent essential, but an intermediary performance required by socio-economic environments, colonial pasts, and intersecting powers like class and ethnicity. A close reading and application of Judith But


Online Reinforcement Learning (RL) has yielded remarkable performance in dynamic wireless communication and networks by interacting with the environment and gradually improving the effectiveness of its policy. As it is normal to witness much uncertainty in such an environment due to the intrinsic randomness of channels and service demands, designing a sample-efficient RL with bounded regrets has significant merits. In this paper, we focus on general Markov Decision Processes (MDPs) with time-evo


Corneal nerve integrity is vital for maintaining ocular surface health and visual clarity, but damage from injury or disease can lead to pain, persistent epithelial defects, and even vision loss. A deeper understanding of how corneal nerves regenerate at the molecular level is key to developing therapies that restore both anatomical structure and function. In this review, we bring together current insights into the pathways that drive corneal nerve repair after injury. We outline the major signa


This dissertation explores how media—photographs, films, and especially video games—variously figure the continent-scale systems (or “enormities”) that structure everyday life in the twentieth and twenty-first centuries. Bringing together problems addressed by prior scholarship under the headings of infrastructure, scalar mediation, cognitive mapping, and the production of space, I analyze media focused on three systems constitutive of everyday life in twenty-first century—containerized shipping


This study examines the application of the principle of procedural speed in child support cases in Ecuador and its relationship to ensuring the best interests of the child. The objective was to analyze the extent to which the lack of effectiveness of this principle limits the timely protection of child support rights. The research used a mixed approach: document review and theoretical analysis, supplemented by surveys of 139 justice operators in the city of Ibarra. The results show that, althoug


O mundo tem passado por transformações significativas, configurando uma verdadeira mudança de época, talvez mesmo uma nova era, a do antropoceno. Doente, a Terra clama por sua convalescência. Em febre, nos aquece excessivamente como resultado de um organismo que há muito tempo é explorado sem obter tempo para se regenerar. Precisamos redefinir imediatamente nossa relação com nosso lar comum, caso contrário, assim como parasitas que exaurem seus hospedeiros, seremos responsáveis por nossa própria


This study aims to determine the effect of leadership style and competence on the performance of finance department employees at RSUD Cibinong. The research employed a quantitative method with a population and sample of 40 employees. Data collection techniques included observation and questionnaires. Data were analyzed using descriptive statistics, multiple regression, multiple correlation, and the coefficient of determination. The results showed that leadership style had a very strong relations


This handbook is designed for the Physical Chemistry 1 module within the Bachelor’s degree program in Chemical Engineering. It presents a comprehensive set of laboratory experiments covering key topics such as the states of matter, solutions and solubility, phase equilibria, thermodynamic principles, and chemical equilibrium. Each experiment includes a structured theoretical overview, detailed procedures, and guidance for data analysis and conclusion formulation. The handbook aims to foster stud


Highway bridge specifications do not account for the presence of railings or parapets in the analysis and design of concrete slab bridges. This paper presents a parametric investigation of the influence of railing or parapet stiffness on the wheel load distribution and bending moments in simply supported, two-equal-span, one- to four-lane concrete slab bridges using the finite-element analysis (FEA). A total of 224 bridge cases were modeled and bridge parameters such as span length and slab widt


A highly electrostatic cellulose acetate (CA)-based electret film for air filtration was fabricated by the electrospinning method assisted with the corona charging technique in this work. The highly polar and hydrophobic poly(vinylidene fluoride) (PVDF) was chosen as the electrostatic reinforcement. The results showed that under the dual electric fields, the dipole charges generated from the conversion from a nonpolar α-phase to a polar β-phase of the dipole inside PVDF and the space charge capt


Music and rhythm are typical features of all human cultures, but their biological origins remain unclear. Recent investigations suggest that rhythmic features of human music are shared with animal vocalizations. Moreover, arousal is known to influence the structure of both human speech and animal sounds. We investigated Coppery titi monkeys' (Plecturocebus cupreus) duet rhythms to assess adherence to rhythmic patterns previously observed only in Old World primates and to deepen our understanding


Plant Genetic Resource.
Taxonomy: Phaseolus vulgaris L.
Common name(s): Common bean
Conserved by: Agneta Finck, Germany
Local sample unique identifier: INCBN_10166_20250319
Method of creation: Acquisition
Date: 2025-03-19
Historical: No
Biological status: Breeding/research material
MLS status: SMTA transfer


ABSTRACT Workers who experience structural barriers in the labour market are overrepresented in the gig economy. There is limited research on how the broader context of labour markets and welfare systems shapes workers' motivations for, and subjective understandings of, ride‐share work. Using established concepts of ‘constrained agency’, ‘labour market objectives’ and ‘life stories’ from labour geography, this study develops a conceptual framework to advance subjective understandings of job qual


Azo dyes such as Congo red are widely used in the textile industry but pose serious environmental and health hazards due to their stability, toxicity, and resistance to conventional treatment methods. This study aims to find a sustainable and effective method for dye biodegradation using <i>Geobacillus thermoleovorans</i> KNG112, a thermophilic bacterium that has not been widely studied for azo dye degradation. Our findings revealed that maximum decolorization was achieved under optimized condit


Digitally synchronized timing distribution system (DTS) has been developed for the LHD fusion plasma measurements, which delivers a 10MHz synchronous clock with the master trigger message through the tree-structured optical fiber links from the master modulator to multiple demodulators to output pre-programmed divided clocks and delayed triggers


Scintillator probes to measure lost fast ions, such as alpha particles, from confined plasmas in LHD by using image intensified charge coupled device camera (LIP-ICCD) or photomultiplier arrays (LIP-PMT-PXI)


This paper presents TCReC, an innovative model designed for reconstructing network traffic characteristics in the presence of packet loss. With the rapid expansion of wireless networks driven by edge computing, IoT, and 5G technologies, challenges such as transmission instability, channel competition, and environmental interference have led to significant packet loss rates, adversely impacting deep learning-based network traffic analysis tasks. To address this issue, TCReC leverages masked autoe


O‘zbekiston iqtisodiyotida norasmiy bandlik — bu rasmiy mehnat shartnomasisiz, soliq organlarida qayd etilmagan holda faoliyat yuritayotgan aholining mehnat shaklidir. Bunday holat nafaqat ishchi kuchining huquqiy himoyasini susaytiradi, balki davlat byudjetiga tushumlarning kamayishiga ham olib keladi. Ushbu maqolada O‘zbekistondagi norasmiy bandlik darajasining statistik holati tahlil qilinadi, uning asosiy sabablari aniqlanadi va iqtisodiy barqarorlikka ta’siri o‘rganiladi. Maqolada mavjud ra


Many one-dimensional (1D) signals, including ECG signals, economic data, particle distributions, seismic waveforms, image rows, and traffic statistics, are nearly piecewise continuous. These signals vary gradually in most regions but vary rapidly in certain narrow regions. Due to the non-uniform distribution of gradients, it is very challenging to well expand these nearly piecewise continuous signals. In this paper, we propose a novel algorithm, called “precise calculation,” to ada


This research aimed to enhance the speaking ability of fifth-grade students at SDN 10 Batuda’a, Gorontalo Regency, through the utilization of flipbook media. The main problem investigated was how the use of flipbook media could significantly improve students' speaking skills. The research employed a Classroom Action Research (CAR) methodology, conducted in two cycles. Each cycle consisted of four essential stages: planning, action, observation, and reflection, with each cycle comprising two meet


Abstract With increasing opportunities for minors to undergo genomic testing, factors influencing young people's decision stability and instability regarding genomic testing are unclear. This interpretive description study examines decision stability when adolescents (13–17) and young adults (18–21) decide whether to learn genetic testing results. Adolescents and young adults enrolled in a clinical trial chose whether they wanted to learn genetic testing results and could modify their decisions


A cross-cultural work culture within a multinational company plays a crucial role in determining employee effectiveness and productivity. Cultural diversity in the workplace can provide benefits in the form of innovation and work efficiency, but also presents communication challenges and differences in values and norms. This study aims to analyze the impact of cross-cultural work culture on employee productivity in multinational companies. Using a phenomenological qualitative approach, data was


The newly proposed Gamma Interval Function is treated in detail in this work for the first time. The function may be applied to all fundamental engineering problems where multiple solutions exist over the whole domain of interest. With the aid of the function, multiple solutions defined over the different parts of the domain can be practically expressed as a single solution. Application problems are selected from mechanical engineering courses such as dynamics, fluid mechanics, heat transfer and


Deploying Large Language Models (LLMs) on edge devices is increasingly important, as it eliminates reliance on network connections, reduces expensive API calls, and enhances user privacy. However, on-device deployment is challenging due to the limited computational resources of edge devices. In particular, the key bottleneck stems from memory bandwidth constraints related to weight loading. Weight-only quantization effectively reduces memory access, yet often induces significant accuracy degrada


Das Projekt »Rassismus & Diskriminierung« (1984-1995) führte aktual-empirische Untersuchungen in Flüchtlingswohnheimen des Deutschen Roten Kreuzes durch. Im Gespräch thematisiert Ute Osterkamp die Entstehungszusammenhänge des Projekts, die Komplexität und Widersprüchlichkeit der Situation vor Ort, sowie die eigenen Schwierigkeiten im Umgang damit. Gegenstand der Diskussion war auch die Frage, wieweit kritisch-psychologische Begriffl ichkeit bei der Aufschlüsselung der Probleme hilfreich ware


Abstract Traditional Chinese Medicine (TCM) is a cultural heritage and tradition brought to Indonesia by Chinese Indonesians from their country of origin. It continues to be practised and remains popular among certain groups. However, the current facilities for TCM do not adequately reflect its therapeutic principles, often eliciting negative emotions from patients and their family caregiver during visits. To address this issue, this research utilized a qualitative method to explore the ideation


317. Mansuphantes parmatus (Tanasevitch, 1990) ^ Records. Absheron-Khizi: Khizi; Guba-Khachmaz: Guba; Mountainous Shirvan: Aghsu, Shamakhi; Shaki-Zagatala: Zagatala. Distribution. Caucasus (Russia, Azerbaijan). References. Lepthyphantes intirmus: Tanasevitch 1987: 310, figs 17–18 (♀; as per Tanasevitch 1990: 26). Lepthyphantes parmatus Tanasevitch, 1990: 26, fig. 10.1–5 (♂ ♀). Mansuphantes parmatus: Saaristo & Tanasevitch 1996: 178, fig. 12D (♂ ♀; transfer from Lepthyphantes); Guseinov & Alieva


To study fast ion confinement and transport mechanisms both in quiescent plasmas and in the presence of magneto-hydrodynamic (MHD) activity, an electric field parallel to the magnetic field type neutral particle analyzer (E||B-NPA) was installed using Micro-Channel Plates (MCPs) in the Large Helical Device (LHD). The E||B-NPA is an established diagnostic used to measure the energy distribution of charge exchange neutral particles escaping from plasmas corresponding to hydrogen, deuterium, and tr


Food security remains one of the most critical global challenges of the 21st century. Traditional tree crops domesticated by indigenous people have the potential to increase food security and improve the livelihoods of smallholders in developing countries. However, the nut characteristics of many traditional tree crop species in the tropics are poorly understood. In particular, physical and chemical characteristics are important to explore when selecting trees to commercialise. Three species, Ba


This study investigates the fabrication of Bingöl pollen (B-pollen) self-assembled films (B-pollen/SAM) on Cu and their corrosion protection performance in a 3.5% NaCl solution. The films were characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle studies. Various electrochemical techniques were employed to examine the influence of some film preparation parameters, including solvent, film formation time, and B-pollen concentration, on film qualit


(1) Background: Somatostatin receptor 2 (SSTR2), a G protein-coupled receptor, is overexpressed in multiple malignancies, including hepatocellular carcinoma (HCC). While SSTR2 has traditionally been viewed as an inhibitory receptor involved in suppressing hormone secretion and cell proliferation, emerging evidence suggests a more complex role in cancer biology. However, the functional implications of SSTR2 expression in HCC remain poorly understood. This study aimed to systematically investigate


Wattpad, as a digital storytelling platform, has become increasingly popular among writers, particularly in producing derivative works known as Alternate Universe (AU) fiction. These works frequently incorporate elements from existing intellectual property, including the names, images, and personas of public figures or fictional characters, often without prior authorization. This study aims to examine the legal protection afforded by copyright law to AU literary works published on the Wattpad pl


In recent years, considerable progress has been made in the field of artificial intelligence and machine learning. This progress allows us to solve increasingly complex problems, but it also requires providing appropriate explanations to understand the actions taken by AI. For this purpose, research into the development of Explainable Artificial Intelligence has been initiated and interest in this topic is constantly growing. This review of XAI methods includes a justification for the need to in


Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are rare, autosomal dominant skeletal dysplasias characterised by disproportionate short stature, joint deformities, and early-onset osteoarthritis. These conditions result from mutations in key cartilage extracellular matrix (ECM) components, including cartilage oligomeric matrix protein (COMP), matrilin-3, and type IX collagen. Although genetically and clinically heterogeneous, PSACH and MED share convergent pathogenic mechan


This research aims to study how effective management of cash reserves affects an oil and gas company's earnings. This research focuses on analyzing liquidity management because its connection to business profits. Company determines their profits through both assets return and equity measures. Liquidity management reveals if a company can fulfill its financial responsibilities while showing how products make money for the business which is why companies must handle this process effectively. Throu


During the operation of steel cable-driven radiation-resistant robots in nuclear industrial environments, the tensile force of a steel cable is influenced by temperature variations, which can cause significant detection errors. To address this problem, this study proposes a temperature-compensated axial force characterization method for steel cables based on the magnetoelastic effect, aiming to ensure the measurement accuracy of magnetoelastic sensors. The principle of the magnetoelastic measure


Purpose - This conceptual work examines how, in times of post-COVID-19 paradigm shift, the employee performance management (PM) process can help multinational corporations (MNCs) strengthen their talent management and, at the same time, meet their future needs. Design/methodology/approach - We take a conceptual approach and present our perspective on what we see as the most critical trends shaping PM and talent management. Contingency theory and Volatility, Uncertainty, Complexity, and Ambiguity


The article analyzes changes in bibliometric tools for assessing the activities of scientific journals and their role in maintaining and developing scientific communication in modern Russia using the example of political science journals, taking into account the political and scientific information context, as well as the specifics of the scientific discipline. The authors assess the impact of the new Science Index RINTS configuration on the structure of the rating of publications on political t


1. Selection of European forest bird species and classification of their biome preferences We selected all species that are related to forest and woodland based on two data sources: Storchová & Hořák (2018) and Tobias et al. (2022), resulting in 107 bird species studied (Data S1). We defined forest bird species as those using environments ranging from closed-canopy forests to more open-canopy woodlands (A. Lehikoinen & Virkkala, 2018; Storchová & Hořák, 2018; Tobias et al., 2022). We determined


The Merdeka Curriculum is an educational innovation implemented to overcome learning losses due to the Covid-19 pandemic and adapt to 21st century educational needs. In its implementation, assessment is a crucial element to support the planning and implementation of learning activities that suit student needs. This study examines five articles on the assessment of the Merdeka Curriculum published between 2023 and 2024. The study results show that assessment in the Merdeka Curriculum includes dia


Introducción: Las revisiones de alcance se utilizan ampliamente en todas las disciplinas sanitarias para sintetizar pruebas, explorar cuestiones de investigación generales e identificar vacíos en la bibliografía. En el caso de temas emergentes y rápidamente cambiantes, como es el caso del uso de la IA generativa, una revisión de alcance sobre revisiones en el tema puede contribuir a identificar vacios y oportunidades metodológicas. Preguntas y objetivos de la investigación: Este estudio pretende


ABSTRAKManajemen kepala sekolah memiliki peran sentral dalam meningkatkan kinerja guru dan mutu pendidikan di sekolah. Penelitian ini bertujuan untuk menganalisis bagaimana strategi manajemen kepala sekolah berkontribusi terhadap peningkatan kinerja guru di SMP Suster Pontianak. Pendekatan kualitatif digunakan untuk memperoleh pemahaman mendalam mengenai perencanaan, pengorganisasian, pelaksanaan, dan evaluasi kinerja guru dalam konteks manajerial kepala sekolah. Data dikumpulkan melalui observa


Gespecificeerde archeologische verwachting Op basis van het archeologisch bureauonderzoek heeft het plangebied een middelhoge verwachting voor de perioden Laat Paleolithicum t/m Romeinse tijd en een hoge verwachting voor de periode Middeleeuwen. Deze verwachting is vooral gebaseerd op de veronderstelde ligging van het overgrote deel van het plangebied binnen een gebied van rivierduinglooiingen en vormde in het rivierduinenlandschap een relatief laaggelegen gebied waar sprake was van vrij vochtig


Abstract Saudi Arabia’s Vision 2030 represents a transformative agenda aimed at reducing the Kingdom’s dependence on oil revenues and fostering economic diversification. This study critically examines the implications of Vision 2030 for the future of the Middle East’s political economy, with a particular focus on its potential to enhance regional cooperation and stability. The study seeks to analyze the effectiveness of Saudi Arabia’s economic diversification strategy in reducing oil dependency,


<p>Guru memiliki peran strategis dalam implementasi Kurikulum Merdeka yang bertujuan menciptakan pembelajaran yang relevan dan bermakna di sekolah dasar. Penelitian ini bertujuan untuk menganalisis peran guru dalam pembelajaran berbasis projek, diferensiasi, dan pembelajaran mandiri sesuai prinsip Kurikulum Merdeka. Metode yang digunakan adalah tinjauan literatur dengan pendekatan naratif, memanfaatkan berbagai sumber seperti jurnal ilmiah, dokumen resmi, dan buku. Data dikumpulkan melalui


Introduction Subjective well-being (SWB), defined as the way people think and feel about their lives, is often used to evaluate happiness. Separated into three components—positive affect, negative affect, and life satisfaction—SWB has been indirectly related to psychiatric symptoms and disorders. However, the relationship between SWB and obsessive-compulsive disorder (OCD) remains relatively unknown. Objectives To determine whether SWB components correlate with the clinical features of OCD. Meth


Introduction: Although the literature on psoas muscle abscess suggests a clinical triad characterized by fever, lower back pain, and pain on hip flexion, patients often present with nonspecific symptoms, making early diagnosis challenging. Objective: To describe the clinical presentation of iliopsoas abscess cases reported at Hospital Santa Rosa between August 2023 and June 2024, along with diagnostic tests, surgical findings, and treatment approaches. Methods: An observational and descriptive s


With the emergence of SARS-CoV-2 variants that may increase transmissibility and/or cause escape from immune responses, there is an urgent need for targeted molecular surveillance methods. While sequencing is the gold standard, it cannot always be immediately scaled or implemented in some settings to detect variants when their frequencies are low. The Applied Biosystems TaqPath COVID-19 assay (ThermoFisher), a PCR test, was discovered to have a distinct signature (spike gene target failure, [SGT


Our findings emphasize the importance of developing professionals who understand the expectations, assumptions, and values of ethnically diverse families which can enhance outcomes for family members across various contexts.


Purpose Entrepreneurial persistence is a crucial decision-making aspect of entrepreneurial activities. Analyzing the factors that influence entrepreneurial persistence can provide support for entrepreneurs to remain perseverant in their ventures, thereby increasing the survival and success rates of new enterprises. To this end, this study aims to examine the relationship between entrepreneurial psychological capital and entrepreneurial persistence while also introducing perceived social support


This paper explores the impact of TikTok's fast-paced content delivery and infinite scrolling on students' attention spans. With the increasing popularity of social media platforms like TikTok, concerns have arisen regarding their effects on cognitive functions, particularly among students. Key findings from existing research indicate that TikTok's rapid pace and constant stimulation can lead to shortened attention spans, reducing students' ability to sustain focus during tasks requiring prolong


Abstract Background: Allergic rhinitis is an immune-mediated condition characterised by flu-like symptoms, fatigue, and impaired cognitive function. Hypothesis: I propose that a three-pronged strategy — ensuring nasal patency, high turnover air ventilation, and high-quality sleep — can downregulate the immune system’s allergic response and reduce symptom burden. Theoretical Basis: This hypothesis draws on evolving immunological frameworks, including the danger theory, which suggests that immune


This paper presents a summary of recent research on the impact of climate risk on the financial system, with a focus on the relationship between physical and transition risk. At the macroeconomic level, climate risk has a significant impact on overall economic growth and volatility. Research has shown that physical and transition risks arising from climate change interact with each other. Climate physical risks exacerbate the level of economic volatility by affecting the market value of the unde


The success of madrasahs can be measured through positive changes in student learning patterns that are enjoyable and aimed at producing intellectually, spiritually, and morally competent generations based on the values of Pancasila and Islam rahmatan lil ‘alamin. The implementation of the Pancasila Student Profile Strengthening Project Rahmatan Lil Alamin (P5RA) in madrasahs under KKMI Paciran, Lamongan, was carried out through optimizing teacher mentoring programs. This mentoring aims to stren


Life on Earth is sustained by complex interactions between organisms and their environment. These biotic interactions can be captured in datasets and published digitally. We present a review and archiving process for such an openly accessible digital interactions dataset of known origin and discuss its outcome. The dataset under review, named globalbioticinteractions/boreux2019, has fingerprint hash://md5/79e5fdb3f1d92cebc2505fe30243eda6, is 138KiB in size and contains 796 interactions with 1 un


We introduce a dimensionless constant for monotone, RC-type step relaxations. Let e(t)be a completely monotone residual of a unit step, representable as a mixture of decayingexponentials e(t) = R e−t/τ dμ(τ ) with τ ∈ [τmin, τmax] (typical for passive RC networks).Define the area A = R ∞0 e(t) dt and the energy E = R ∞0 e(t)2 dt, both with units of time, andthe ratio R = E/A (dimensionless). Under a bounded time-constant spread ρ = τmax/τmin,we prove the sharp lower boundR ≥ Cρ :=√ρρ + 1 ,and id


The recruiting industry is undergoing a revolutionary change as more and more businesses integrate artificial intelligence (AI) into their operations. AI technologies are being used by businesses more and more to automate and expedite the hiring and selection process for new hires. This study is to investigate the various ways that artificial intelligence (AI) is influencing the sourcing, screening, and selection of candidates during the recruitment process. This paper examines the consequences,


Kelompok Jaya Bersama merupakan sub kelompok nelayan Harapan Bersama yang saling terintegrasi. Kelompok jaya bersama fokus pada produksi makanan berbasis mangrove dan hasil laut, namun mengalami kendala dalam pemasaran. Produk utama yang diproduksi dan dipasarkan seperti: sirup sidabu, dodol sidabu, emping api-api, stik jeruju, dan amplang lomek. Semua bahan utama produk tersebut berasal dari mangrove yang terdapat di lokasi kegiatan dan ikan berasal dari hasil tangkapan dari laut. Dari hasil di


The seismic vulnerability of existing reinforced concrete (RC) buildings that constitute a large portion of the urban building stock has become a growing concern for urban safety. This situation was once again revealed by the massive destruction that occurred in RC structures following the 2023 Kahramanmaraş earthquakes. Particularly in buildings constructed before 1990 and without adequate engineering services, destruction and damage were much greater. In this paper, structural models were crea


Vegetation resilience is a core indicator that reflects an ecosystem’s ability to maintain its structural and functional stability after disturbance. Although numerous studies have confirmed that vegetation cover in China has consistently shown an increasing trend in greenness, systematic quantitative assessments of its vegetation resilience remain relatively scarce. To address this gap, this study quantifies the resilience of six commonly used vegetation indices based on Critical Slowing Down (


Penelitian ini bertujuan untuk menganalisis dampak kompensasi terhadap kinerja karyawan di Grand Orchardz Hotel Kemayoran Jakarta. Kinerja karyawan merupakan faktor utama dalam menciptakan kualitas layanan yang memuaskan bagi pelanggan. Kompensasi, baik finansial maupun non-finansial, diharapkan dapat meningkatkan motivasi dan kinerja karyawan. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan wawancara mendalam terhadap 10 karyawan dari departemen operasional di hotel. Hasil


Este artigo analisa a planificação econômica, demonstrando que, na prática, ela é conceitualmente mais simples que os mecanismos do mercado capitalista. O caráter anárquico do mercado impede previsões significativas e a resolução definitiva de crises periódicas, enquanto a racionalidade interna das empresas, que em muitos aspectos tiveram maiores êxitos a partir de elaborações teóricas oriundas da experiência soviética, direta ou indiretamente, evidencia formas mais eficientes de organizar a pro


Bayesian optimization (BO) is effective for expensive black-box problems but remains challenging in high dimensions. We propose NeST-BO, a local BO method that targets the Newton step by jointly learning gradient and Hessian information with Gaussian process surrogates, and selecting evaluations via a one-step lookahead bound on Newton-step error. We show that this bound (and hence the step error) contracts with batch size, so NeST-BO directly inherits inexact-Newton convergence: global progress


From the perspective of digital empowerment, this study attempts to construct a digital literacy evaluation model for Chinese teachers consisting of data collection and storage, processing and mining, and feedback and application of results, with a view to providing strategic references to the problems of Chinese teachers' digital literacy evaluation. The improvement of teachers' digital literacy is the core key to the change of parenting style and the development of education quality in the dig


Guardian AI is an open-source governance framework for frontier AI. It is not a regulator, but a technical and institutional standard — scaffolding, not a fortress. The framework includes adaptive risk assessment (Compass Index), checks and balances, and a voluntary-but-sticky enforcement model. It is designed to be temporary, transparent, and replaceable as better institutions emerge.


Line integrated electron density on the horizontal mid-plane is measured by the two-color millimeter-wave interferometer, with the sampling rate of 1 micro-second (0.001 ms) being faster than 0.1 ms of 'mmw-nel'.


Abstrak: Alur berpikir merujuk pada proses sistematis yang melibatkan pengamatan, analisis, sintesis, dan refleksi dalam memahami suatu konsep atau menyelesaikan masalah. Pendekatan ini sangat relevan untuk diterapkan dalam lingkungan sekolah alam, yang pada dasarnya menekankan pada pembelajaran kontekstual berbasis pengalaman langsung. Pendidikan yang berbasis pada pengalaman langsung dan pemecahan masalah kini semakin mendapat perhatian dalam dunia pendidikan, khususnya di sekolah – sekolah al


Anorectal melanoma (AM) is an uncommon and potentially fatal form of melanoma. It occurs in the anal canal or rectum, representing approximately 1%–2% of all melanomas. The incidence of AM has been rising, likely due to improved diagnostic techniques and increased awareness. Unlike cutaneous melanoma, AM often presents at an advanced stage, with symptoms such as discomfort, changes in bowel habits, and rectal bleeding. With a high index of suspicion required due to its nonspecific presentation,


Fragmented identity is not merely a theme in the works of Toni Morrison, Roxane Gay, and Don DeLillo—it is embedded in the very structure of their narratives. This paper examines how fragmentation functions as both theme and form in selected contemporary American fiction. Bringing together Deleuze and Guattari’s schizoanalysis with feminist psychoanalytic thought from Kristeva and Irigaray, this study engages with the ways in which literary form becomes a site for negotiating trauma, memory, and


Abstract Tell Brak is one of the largest sites in Upper Mesopotamia, where urbanism and social complexity already emerged in the late 5th and early 4th millennia BCE. This paper combines ceramic petrography and trace element analyses to examine how these changes impacted pottery production and regional trade. The results indicate that paste preparation modes, unlike shaping procedures, remained unaffected by urbanization, with paste recipes showing no link to variations in vessel function or tec


Climate change has introduced significant uncertainties in hydrological systems, such as erratic rainfall, prolonged droughts, and extreme weather events, challenging traditional water infrastructure and forecasting models. Conventional hydrological models, whether statistical or physical, often struggle to handle real-time variables, intricate relationships, and nonlinear dynamics. In this context, artificial intelligence (AI) emerges as a powerful solution, providing data-driven modeling capab


Applications of reduced basis method emulators are increasing in low-energy nuclear physics because they enable fast and accurate sampling of high-fidelity calculations, enabling robust uncertainty quantification. In this paper, we develop, implement, and test two model-driven emulators based on (Petrov-)Galerkin projection using the prototypical test case of two-body scattering with the Minnesota potential and a more realistic local chiral potential. The high-fidelity scattering equations are s


Research purpose. To estimate the comparative aspects of the functional state of the system mother-placenta-fetus at a antenatal hypoxia. Materials and methods. A basic (1th) group was made by 55 cases of death of fetus from a antenatal hypoxia in terms of 23-40 weeks at a singleton pregnancy: 55 placentas and 52 fetuses (in 3 cases a section was not produced). These 55 the most difficult for diagnostics supervisions of antenatal fetal death were included by us in a 1 group of research on the ba


Forschungsziel: Das vorliegende Projekt untersucht, wie Gedächtnisprozesse die evaluative Konditionierung (EC) beeinflussen also wie sich die Bewertung eines neutralen Stimulus (CS) durch wiederholte Paarung mit positiven oder negativen Bildern (US) verändert. Im Zentrum steht die Frage, ob die Bewertung eines CS stärker durch die letzte Paarung (Recency-Effekt) oder durch die am häufigsten auftretende Paarung (Frequency-Effekt) bestimmt wird, in Abhängigkeit vom zeitlichen Abstand zwischen letz


Following on from Part 1, (The Northern Mariner/Le marin du nord 34, no. 3 (2024)), Part 2 considers the later history of Andrew Weir’s Bank Line and its subsidiary shipping companies from 1970 through changes in name of its shipping operation to dissolved company status in 2016. As in Part 1, in tandem we also trace the history of Bank Line’s holding company, Andrew Weir and Co. Ltd.


This study investigates the particle deposition characteristics within a novel cavity featuring a transverse baffle oriented perpendicular to the coolant flow, positioned upstream of the pre-swirl nozzles in the turbine disk cavity. The baffle-induced vortex enhances particle deposition, thereby reducing particle ingress into the turbine disk cavity. Against such a background, a comparative analysis was hereby conducted to delve into the deposition characteristics of particles across four baffle


Many recent text-to-speech (TTS) systems are built on transformer architectures and employ cross-attention mechanisms for text-speech alignment. Within these systems, rotary position embedding (RoPE) is commonly used to encode positional information in text and speech representations. In this work, we introduce length-aware RoPE (LARoPE), a simple yet effective extension of RoPE that improves text-speech alignment. Unlike RoPE, which relies on absolute indices, LARoPE computes relative distances


BACKGROUND: Meditation practices have demonstrated numerous psychological and physiological benefits, but capturing the neural correlates of varying meditative depths remains challenging. In this study, we aimed to decode self-reported time-varying meditative depth in expert practitioners using electroencephalography (EEG). METHODS: Expert Vipassana meditators (n = 34) participated in 2 separate sessions. Participants reported their meditative depth on a personally defined 1 to 5 scale using bot


The primary function of housing is to respond to human lifestyles, and currently, many residences are designed with less consideration for the preferences and needs of their inhabitants. In this research, aimed at examining the impact of individuals' lifestyles on the physical aspects of housing and addressing the question, “What are the contemporary spaces based on today’s lifestyle?”, a questionnaire was developed based on the Likert scale. The statistical population consists of 298 residents


Abstract The study explores English language teachers' attitudes toward Philippine English (PhE) and examines how these attitudes vary based on age, gender, and educational attainment. Given the increasing recognition of New Englishes, it is crucial for educators to acknowledge the legitimacy of PhE while promoting language awareness. However, previous research suggests that some teachers hold negative views toward PhE, potentially impacting its acceptance in educational settings. Utilizing a mi


In close collaboration with a large community of researchers and FORRT, we have developed materials for the newly established diamond open-access journal: Replication Research (replicationresearch.org). This report was created to enable other researchers and journals to cite, view different versions, and reuse its contents.


Arteriviruslar insan dışındaki diğer memelileri enfekte eder. Bugüne kadar at, domuz, sıçan ve maymunlardan izole edilmiş 13 tür tanımlanmıştır. Bu ailede bulunan viruslar farklı türlerde klinik ve persiste enfeksiyonlara neden olurlar. Bu bölümde Arteriviridae ailesinin genel özellikleri ve bu ailede bulunan Variarterivirinae alt ailesinin Betaarterivirus cinsinin domuzlarda oluşturduğu Domuzların Reprodüktif ve Respiratorik Sendromu (PRRS) hakkında ayrıntılı bilgi verilmesi amaçlanmıştır. PRRS


With the increasingly serious problems of global climate change and resource shortages, green building design and energy efficiency improvement have become important research directions in architectural engineering. This study explores how to effectively combine green building design concepts in architectural engineering to improve energy efficiency significantly. Through in-depth analysis of green building cases at home and abroad, this study proposes various design strategies, including optimi


Esta entrevista integra o método qualitativo desenvolvido na tese de doutoramento intitulada O Custo da Causa: ONGs, financiadores e os direitos humanos sob o neoliberalismo, defendida na Universidade de São Paulo – Faculdade de Direito. As entrevistas foram realizadas no primeiro semestre de 2025, conduzidas e integralmente transcritas pela pesquisadora Lorraine Carvalho Silva.


Acoustic levitation enables non-contact manipulation of particles, crucial for applications in microassembly, biochemical analysis, and material processing. However, conventional acoustic levitation systems typically rely on bulky transducer arrays or complex architectures, limiting their practical implementation and portability. Here, we demonstrate a miniaturized acoustic particle gripper based on a high transmit (Tx) pressure single Sc0.3Al0.7N piezoelectric micromachined ultrasonic transduce


Five Venus missions are under development to study the planet in the next decade, with both NASA's VERITAS and ESA's EnVision featuring a geophysical investigation among their objectives. Their radar and gravity experiments will determine Venus's orientation, enabling analyses of its spin dynamics to infer relevant geophysical and atmospheric properties. This work aims to characterize Venus's polar motion, defined as the motion of its spin axis in a body-fixed frame. We focus on signatures from


Abstract The article deals with the basic laws of composition and their application in creating graphic design objects. The importance of adherence to the principles of composition for achieving a harmonious and effective visual perception of design products is determined.


Alignment-free RGB-Thermal (RGB-T) salient object detection (SOD) aims to achieve robust performance in complex scenes by directly leveraging the complementary information from unaligned visible-thermal image pairs, without requiring manual alignment. However, the labor-intensive process of collecting and annotating image pairs limits the scale of existing benchmarks, hindering the advancement of alignment-free RGB-T SOD. In this paper, we construct a large-scale and high-diversity unaligned RGB


This presentation analyses anarchist publications in Italian published in Egypt between 1902 and 1914. The work represents an update of the knowledge available to date, based on new material found in the Historical Archives of the Ministry of Foreign Affairs in Rome (Asdmae)


Using a bibliometric analysis with CiteSpace, this paper examines the current state and developmental trends of multimodal linguistics research, focusing on 2536 references from the Web of Science database from 2013 to 2023. The study also considers publication trends, top countries, universities and authors, as well as the frequency of most cited journals and literature, research topics and emerging hotspots. The results show that the field of multimodal research has grown rapidly over the last


Este artigo/aula oferece uma introdução crítica à relação entre a química e a poluição ambiental. Explorando os principais tipos de poluentes — da água, do ar e do solo —, o texto destaca os impactos das atividades humanas nos ecossistemas e na saúde pública. A compreensão dos ciclos biogeoquímicos, como os do carbono e da água, é apresentada como base para estratégias de mitigação ambiental. Também são abordadas a gestão de resíduos, o controle de metais pesados e o uso de tecnologias limpas co


Abstract Biofuels offer a sustainable alternative to fossil fuels, utilizing renewable biomass feedstocks to meet the growing energy demand while reducing environmental impact. However, the efficiency of biofuel production heavily depends on the pretreatment methods used for conversion of biomass. Analyzing these methods is essential for improving the viability of biofuel production and facilitating their scale-up. This study presents a bibliometric analysis of scholarly contributions to biomass


Introducción: El uso de redes sociales es común entre los estudiantes, facilitando la comunicación, el intercambio de información y su aplicación en diversos aspectos académicos. Objetivo: Analizar el uso, la frecuencia y la percepción de la utilidad de las redes sociales con fines académicos en estudiantes del área de la salud. Material y Método: Estudio transversal con 685 estudiantes del área de salud, muestreo por conveniencia. Se aplicó un cuestionario en el aula para recoger datos sobre va


ABSTRACT Trade Secrets (TS) are vital for innovation‐driven companies, and their loss can inflict significant financial and reputational damage, particularly in the absence of established policies to mitigate misappropriation in the UK. The current academic literature lacks detailed strategies for firms to effectively address these threats. This paper aims to bridge the research gap by conducting interviews with industry professionals and analyzing UK legal cases related to TS misappropriation.


Eating is a fundamental human activity, yet its significance extends far beyond survival, encompassing personal values, cultural influences, and psychological dimensions. This study introduces the concept of "Thoughts on Eating" (ToE) as a foundational framework for understanding individual eating attitudes and behaviors. ToE captures diverse perspectives on food and eating, ranging from health maintenance to emotional and social dimensions.In this study, we developed and validated the Thoughts


Quantum photonic integrated circuits (QPICs) offer a promising path toward scalable quantum technologies. QPICs rely on the integration of many quantum photonic components and interconnecting optical waveguides for generation, manipulation, and detection of single photons. A key challenge in QPICs is the management and minimization of optical losses, which is particularly critical for single-photon applications. In this paper, we investigate optical propagation losses in strip waveguides within


The integration of Artificial Intelligence (AI) into the field of Islamic studies presents both remarkable opportunities and profound challenges. With the exponential growth of digital resources, AI can significantly enhance the accessibility, organization, and comparative analysis of Qur’anic exegesis, Hadith collections, jurisprudential literature, and historical sources. For scholars and students alike, AI-driven tools provide faster search capabilities, automated classification of texts, lin


The objective was to evaluate the beneficial effects of a reminiscence based intervention (‘Remember-ME’) on both cognitive (i.e. autobiographical memory and verbal memory) and psychological dimensions (i.e. life satisfaction, psychological well-being and loneliness) in cognitively intact community-dwelling older adults A quasi-experimental design was used to evaluate the effects of the program, including a pre-test and a post-test. The total sample consisted of 52 healthy community-dwelling ret


Jujube (<i>Ziziphus jujuba</i> Mill.) is an important fruit tree mainly planted in arid and semi-arid regions, but its genomic resources for haplotype resolution are still limited. In this study, we used PacBio HiFi long-read sequencing and Hi-C data to generate high-quality, haplotype-resolved genome assembly of the main jujube variety 'Huizao'. Genome annotation identified protein-coding genes in two haplotypes, and comparative analysis revealed large-scale structural variation and allele diff


This research project conducts a scoping review to systematically map and synthesize the existing evidence on the use of enteral versus parenteral ketogenic diets for managing critically ill children with refractory and super-refractory status epilepticus in pediatric intensive care units. The primary purpose is to address a significant clinical gap by directly comparing these two administration routes, including enteral feeding via a tube and intravenous parenteral nutrition, to determine their


<sec> <title>BACKGROUND</title> Oral diseases, significantly driven by dental plaque, remain a major global health concern. Traditional toothbrushing instruction methods are limited in interactivity and long-term skill retention. Recent digital innovations, particularly virtual reality (VR), present promising opportunities for interactive, self-directed oral health education. </sec> <sec> <title>OBJECTIVE</title> This randomized controlled trial aimed to evaluate the effectiveness of VR-based to


Introduction: Several glycemic traits indicate risk for type 2 diabetes (T2D). Although previous studies have identified many genes associated with glycemic traits, the underlying molecular mechanisms remain unclear. Identifying gene expression signatures, both protein-coding mRNAs and long non-coding RNAs (lncRNAs), associated with glycemic traits may provide insight into the biological pathways that contribute to glycemic regulation and the development of T2D. Methods: Whole blood RNA-seq data


The use of artificial intelligence in screening mammography was supported by patients primarily as a second reader, despite concerns about loss of personal interaction, privacy, transparency, and bias.


Integrated sensing and communication (ISAC) has attracted extensive attention as a key technology to improve spectrum utilization and system performance for future wireless sensor networks. At the same time, active surveillance, as a legitimate means of surveillance, can improve the success rate of surveillance by sending interference signals to suspicious receivers, which is important for crime prevention and public safety. In this paper, we investigate the joint optimization of performance of


The purpose of this study is that the combination effects of Peyronie’s disease (PD) therapy with Phosphodiesterase type 5 inhibitors (PDE5i) plus acetylsalicylic acid on improve curvature progression and pain in the active phase of disease. We performed a retrospective cohort study of 161 patients affected by PD in active stage and erectile dysfunction treated with tadalafil 5 mg once daily were divided in two groups. Group A(GA): 93 men treated with only PDE5i (tadalafil 5 mg) for 1 year or mo


The effects of certain purified plasma proteins on the coagulation-activation and platelet-adhesion properties of glass surfaces have been investigated. Albumin, transferrin, gammaG globulin, gammaM globulin and fibrinogen were obtained in highly purified form; ceruloplasmin was a more crude preparation. Each of these proteins was found to adhere to glass surfaces and influence reactions of these surfaces with blood. gammaG globulin or albumin adsorbed to glass markedly inhibited activation of t


Forty eight cases with primary idiopathic myocardiopathies were diagnosed in clinical conditions for a period of 2 years. Among the patients, being mainly young, at the age of 17-20--hypertrophic myocardiopathies predominated (44 cases), 27 of them were obstructive forms. Modern investigation methods were used in making the diagnosis of the cases, including cardiac probe with angio--and ventriculography, isotope gamma cardiographic, echocard ographic investigations as well as pharmacodynamic fol


The ability of midbrain homogenates from two strains of mice to accumulate several putative neurotransmitters, or their precursor in the case of acetylcholine, has been examined. The high-affinity transport mechanisms toward glutamate, GABA, dopamine, and glycine were similar in both strains. The seizure-prone DBA21BG strain had a significantly higher capacity to transport choline than did the relatively seizure-resistant C57BL/6 IBC mice. Howaver, no difference in the density of muscarinic bind


This report describes the measures being applied to control malaria in China and outlines the present situation in the country. In the 1940s, it was estimated that approximately 350 million people were at risk of infection and that about 30 million cases of malaria occurred annually. In the last 30 years, large-scale antimalaria campaigns have been established and have achieved much success. In 1979, there were just over 2 million reported cases of malaria and approximately 64% of the population


The pathologies of diabetic micro- and macroangiopathy are different, suggesting that diabetes affects these two types of vascular tissue in a dissimilar manner. We have compared insulin receptors and the effects of insulin on cultured endothelium from calf retinal capillaries and aorta, and the vascular supporting cells, retinal pericytes, and aortic smooth muscle cells. 125I-insulin binds to high affinity insulin receptors on all four cell types. Receptor concentrations were similar except for


A clinical report is presented of a patient who developed Salmonella bovis-morbificans infection and ruptured an abdominal aortic aneurysm as a complication. The management is discussed and treatment suggested.


Pseudoaneurysms of the extracranial arterial tree are uncommon. To our knowledge, four cases of pseudoaneurysm of the internal maxillary artery have been reported, but there have been no reports of pseudoaneurysm of the extracranial segment of the middle meningeal artery. A 15-year-old girl, who suffered a gunshot wound in the right maxillary region, suffered a pseudoaneurysm of the proximal portion of the middle meningeal artery, as shown by carotid angiography six days after injury. The lesion


We studied the localization of nonspecific esterase activities in cloned guinea pig aortic endothelial cells using ultrastructural cytochemistry. Weibel-Palade bodies (WPB), which are known to contain von Willebrand protein, were positive for esterase, defining a heretofore unrecognized activity of these organelles. Esterase activity was also found localized to the external surface of the plasma membrane, to cytoplasmic lipid bodies, and to the outer (cytoplasm-facing) surface of certain membran


Epidermoid cyst of the testis, which is regarded as benign monodermal development of differentiated teratoma and comprises less than 1% of all testicular tumors, was found within the tunica albuginea in a 23-year-old man. Following peroperative histologic confirmation of its benign nature, the cyst was locally removed, thereby avoiding orchiectomy.


Electrophoretic data revealed the presence of various isozymes of endoglucanase and beta-glucosidase, the number of which varied from one to three in various species of the genus Aspergillus. pH 5.0 was optimum for all the isozymes whereas metal ion treatment showed complete inhibition of almost all the isozymes by Hg2+ and partial inhibition by Ca2+ and Co2+ of isozymes of both the enzymes. An alteration in the electrophoretic mobility of isozymes of beta-glucosidase was also noticed in some sp


Murine retrovirus infection induces loss of vitamin E and immune dysfunction with loss of cytokine production by T-helper cells. Therefore interferon-gamma (IFN-gamma) was given during dietary vitamin E supplementation to effectively prevent murine retrovirus-induced immunosuppression, cytokine dysregulation, and development of murine AIDS. Administration of IFN-gamma during vitamin E supplementation significantly prevented development of retrovirus-induced suppression of splenic natural killer


Growth kinetic data of human tumours, obtained by flow cytometric analysis of cells labelled with bromodeoxyuridine (BrdUrd) might provide prognostic information and allow prediction of response to radio- and chemotherapy. However, the theoretical models applied for calculation of growth kinetic data are not fully evaluated. The purpose of this study was to investigate the dependence of the estimation of DNA synthesis time (Ts) on sampling time after BrdUrd labelling, using four different mathem


Adenosine is one of the normal elements in body fluid including extracellular fluid within the CNS. Its normal level is 0.03-0.3 mumol/L. When ATP's metabolism loses balance, for example, during ischemia, the level of adenosine increases dramatically, may reach as much as 1000 times of the normal. Adenosine plays many physiological and pathological roles in CNS via its receptors. It is recognized as an inhibitory neuromodulator playing a neuroprotective role in CNS.


Fortuitously discovered after an episode of bovine hemorrhagic disease, the oral antivitamin K anticoagulants inhibit a posttranslational modification of coagulation factors II, VII, IX, and X that is essential for bioactivity. They also influence formation of regulatory proteins C and S. Although their influence on the extrinsic pathway may be measured using the prothrombin time, a modification thereof produces the International Normalized Ratio (INR) which should allow for less interlaboratory


The production and activation of matrix-degrading proteinases such as the matrix metalloproteinases (MMP) by lymphocytes is likely to be an important factor in facilitating lymphocyte trafficking through the endothelial barrier and the extracellular matrix. Leukocyte infiltration into inflammatory sites occurs as a response to members of the chemokine superfamily and other inflammatory mediators. In the present study, highly purified leukocyte subpopulations were cultured with or without chemoki


We examined D2-dopamine receptor containing neurons in cultures of neonatal rat striatum for apoptosis following dopamine treatment. Exposure to cultures to micromolar concentrations of dopamine resulted in 60-70% killing of D2-dopamine receptor neurons within 24 hr. We also utilized a double labeling procedure to determine that treatment with dopamine induced apoptosis in D2-dopamine receptor containing neurons. These results suggest that loss of D2-dopamine receptor containing neurons during a


Recently, constitutively active mutants of MEK (MAP/ERK kinase) were shown to be capable of transforming cells to tumorigenicity suggesting that MEK can function as a dominant oncogene and potentially play a role in human carcinogenesis. Human lung cancer cells exhibit mutations in other components of the MAP kinase signaling pathway such as the Her-2/neu and ras oncogenes. Thus, the coding sequences of both MEK-1 and MEK-2 cDNAs from human lung cancer cell lines were screened by single strand c


Serotonin (5-hydroxytryptamine) has been known for the last half century to influence vasoactivity and to participate in neurotransmission. More recently, this compound has been recognized to cause proliferation of a variety of cells in culture, including those of vascular smooth muscle. Furthermore, the proliferative effect is synergistic with that of more conventional growth-producing polypeptides. A hypertrophic, as well as a proliferative response, has been shown to occur in some smooth musc


BACKGROUND & AIMS: Interleukin 1beta (IL-beta) and tumor necrosis factor alpha (TNF-alpha) are present in the neuromuscular layers during intestinal inflammation and directly affect intestinal smooth muscle function. We investigated whether IL-1beta and TNF-alpha modulate T-cell activation by murine intestinal smooth muscle cells (ISMCs). METHODS: alpha- and gamma- actin expression in ISMCs was confirmed using reverse-transcription polymerase chain reaction (RT-PCR). ISMCs were analyzed for clas


A genetic block was introduced in the first condensation step of the polyketide biosynthetic pathway that leads to the formation of 6-deoxyerythronolide B (6-dEB), the macrocyclic precursor of erythromycin. Exogenous addition of designed synthetic molecules to small-scale cultures of this null mutant resulted in highly selective multimilligram production of unnatural polyketides, including aromatic and ring-expanded variants of 6-dEB. Unexpected incorporation patterns were observed, illustrating


The allosteric modulation of GABAA receptors in the rat brain cortex by neurosteroids was studied at different developmental stages. GABAA receptors were identified using [3H]muscimol binding to membrane preparations obtained from embryos and neonates (postnatal day 0-PN0; postnatal day 5-PN5). Data analysis disclosed a unique population of binding sites at all ages tested. An increase in the number of receptors was observed during development reaching almost adult levels at PN5. The neurosteroi


Between 1987 and 1992, 48 patients with ruptured Achilles tendons were operated on using a standardized microinvasive technique; 30 patients underwent functional postoperative treatment, whereas 18 underwent conventional cast immobilization. Validated tests and a specially designed instrument for measuring strength and endurance were used for followup examinations. Patients undergoing functional postoperative treatment were hospitalized for shorter periods and lost fewer days from work than thos


Antibodies that bind well to the envelope spikes of immunodeficiency viruses such as HIV type 1 (HIV-1) and simian immunodeficiency virus (SIV) can offer protection or benefit if present at appropriate concentrations before viral exposure. The challenge in antibody-based HIV-1 vaccine design is to elicit such antibodies to the viruses involved in transmission in humans (primary viruses). At least two major obstacles exist. The first is that very little of the envelope spike surface of primary vi


A cohort of 1640 hospitalized drug addicts was studied over an 8-year period, and consisted of 678 heroin users, 578 amphetamine users and 384 users of other drugs. In total, 234 addicts were HIV-positive, most of them heroin users. During the observation period, 214 deaths occurred in the cohort. The total mortality was 2.2% annually. Death linked to injection of heroin was the main cause of death not only among heroin users but also among subjects classified as users of amphetamines or other d


The differential diagnosis of ascites often leads to confusion and an inability to exclude its multitude of causes in many patients. In this review, we outline the clinical features and laboratory investigations that usually elucidate the cause of ascites for the clinician in a simple and logical manner. Roughly 80-85% of cases of ascites are related to underlying chronic liver disease, but cardiac failure, tuberculosis, malignancy-related ascites and other less common causes should always be co


Plant Genetic Resource.
Taxonomy: Triticum aestivum L. subsp. aestivum
Common name(s): Wheat
Other names: AVENTURERO COENEO 3-030CSH-143B
Conserved by: Centro Internacional de Mejoramiento de Maíz y Trigo (CIMMYT), Mexico
Local sample unique identifier: BW 42068
Method of creation: Acquisition
Date: 2007
Other identifiers: n/a,BW42068, n/a,-030CSH-143B, n/a,GID 4033666, n/a,CID 450148 SID 737
Historical: No
Biological status: Traditional cultivar/landrace
MLS sta


Palmar and fingerprints were taken from 70 patients with Darier's disease and 409 normal controls. The dermatoglyphic characteristics of each group were determined and comparisons were made between them. Dermatoglyphic abnormalities were found; some confirmed previous findings and some were novel, but they are too small in degree and frequency to be of use diagnostically.


Our objective was to determine the effects of anticoagulants and blood loss on hemodynamic, hematologic, and coagulation parameters following autotransfusion in an animal model of intraabdominal hemorrhage. We performed a prospective, randomized observational animal study at an animal research laboratory at a university medical center. Eight Landrace, domestic pigs, weighing 17-23 kg, each underwent jugular venous and iliac arterial catheterization and laparotomy with retroperitoneal dissection


Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an important regulator of T cell homeostasis. Ligation of this receptor leads to prominent downregulation of T cell proliferation, mainly as a consequence of interference with IL-2 production. We here report that CTLA-4 engagement strikingly selectively shuts off activation of downstream T cell receptor (TCR)/CD28 signaling events, i.e., activation of the microtubule-associated protein kinase (MAPKs) ERK and JNK. In sharp contrast, proximal TCR signal


Rat cholecystokinin-B (CCK-B) receptors were transfected into Chinese hamster ovary (CHO)-K1 (CHO-CCK-B) and Swiss 3T3 (Swiss 3T3-CCK-B) cells, and the effects of receptor activation on cell proliferation and intracellular signaling were investigated. CCK octapeptide (CCK-8) treatment had no effect on cell growth in quiescent CHO-CCK-B cells but inhibited DNA synthesis, proliferation, and colony formation when the cells were grown in fetal bovine serum (FBS). In contrast, CCK-8 stimulated DNA sy


BACKGROUND: The blood urea nitrogen to creatinine ratio (BUN/CREAT) is believed to reliably discriminate upper gastrointestinal bleeding (UGIB) from lower gastrointestinal bleeding (LGIB). However, studies evaluating subsets of bleeders in whom this ratio may have real diagnostic utility are lacking. METHODS: Over a 50-month period, all patients evaluated for UGIB and LGIB by our gastroenterology consultative service had demographic, clinical, and laboratory findings recorded on admission. Endos


The aim of this study was to investigate the state of Helicobacter pylori (Hp) infection in gastroenterology nurses and to prove the effect of gloves on protecting nurses against Hp infection. 157 subjects working in hospitals in Nanjing were investigated, in which there were gastroenterology nurses, and gastroenterologists, and nongastroenterology nurses. All of them were examined for anti-Hp IgG by means of a indirected enzyme-linked immunosorbent assay. No significant difference of the mean a


We study observed the mutual benefits of pancreas and liver in combined hepaticopancreatic transplantation in rats. The result indicated that pancreas, when transplanted with liver, could survive for a significantly longer time (13.4 +/- 1.01 days) than it transplanted alone (9.2 +/- 1.14 days) (P < 0.05). The interstitial rejection was mild and its rejection grade was significantly different from that of pancreas transplanted alone (P < 0.05, chi 2 test). The liver, when transplanted with pancr


Outbreaks of aseptic meningitis-like illnesses have occurred in high school football players for reasons that may include the close contact among players and the overlap of football season with the peak enterovirus season. The main symptoms are fever, headache, and neck or back stiffness; physical findings may include signs of meningeal irritation. Evaluation of the cerebrospinal fluid can confirm the diagnosis. Treatment of viral meningitis is generally supportive, and patients usually do well,


In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2+ ionophore application, normally active tonic motor axons continue to grow, whereas inactive phasic motor axons retract and often degenerate. To determine the role of Ca2+ regulation in this difference, we measured the intracellular free Ca2+ concentration ([Ca2+]i) with fura-2. Growth cones from t


Advances in microarray technology enable massive parallel mining of biological data, with biological chips providing hybridization-based expression monitoring, polymorphism detection and genotyping on a genomic scale. Microarrays containing sequences representative of all human genes may soon permit the expression analysis of the entire human genome in a single reaction. These 'genome chips' will provide unprecedented access to key areas of human health, including disease prognosis and diagnosis


The evidence for a visual deficit in dyslexia is inconclusive. We have developed several tests to investigate the parallel pathways of the visual system which can be applied to dyslexic subjects. Using the techniques of electroretinography, visual evoked potentials, adaptometry and contrast sensitivity, special protocols have been designed to elicit responses from these parallel pathways. These techniques are also applicable in the investigation of many pathological conditions, and of interest f


Holins are a diverse group of small integral membrane proteins elaborated by bacteriophages to lyse bacterial hosts and effect release of progeny phages in a precisely timed manner. Recently, the holin S gene of phage lambda was overexpressed and the holin protein was purified to homogeneity by means of an oligohistidine tag procedure and immobilized metal affinity chromatography (D. L. Smith, D. K. Struck, J. M. Scholtz, and R. Young, J. Bacteriol. 180:2531-2540, 1998). Numerous locations withi


OBJECTIVE: To analyze the effects of 5-fluorouracil (5-FU) chemotherapy combined with preoperative irradiation and the role of intraoperative electron beam irradiation (IOERT) on the outcome of patients with primary locally advanced rectal or rectosigmoid cancer. METHODS: From 1978 to 1996, 145 patients with locally advanced rectal cancer underwent moderate- to high-dose preoperative irradiation followed by surgical resection. Ninety-three patients received 5-FU as a bolus for 3 days during the


To test models for the pentameric structure of phospholamban (PLB) and study its structure and molecular dynamics in SDS solution, we characterized recombinant PLB and several of its mutants by (a) reactivity of cysteine residues toward DTNB [5, 5'-dithiobis(2-nitrobenzoic acid)] and a thiol-reactive spin label, (b) oligomeric state on SDS-PAGE, and (c) EPR of the spin-labeled proteins. WT-PLB has three cysteine residues (36, 41, and 46), all located in the hydrophobic C-terminal transmembrane r


In Drosophila, pole cells, the progenitors of the germ line, are induced by the factors localized in the posterior pole region of oocytes and cleavage embryos, or germ plasm. Polar granules in germ plasm are electron-dense structures and have been proposed to contain factors essential for pole cell formation. Mitochondrially encoded large ribosomal RNA (mtlrRNA) has been identified as a component of polar granules. We previously have shown that mtlrRNA is able to rescue embryos that fail to form


BACKGROUND: To determine optimal management of major abdominal arteriovenous fistulae and define factors affecting outcome. METHODS: We reviewed clinical data of 18 patients, 16 males and 2 females, who underwent repair of major abdominal arteriovenous fistulae between 1970 and 1997. RESULTS: Sixteen patients had primary fistula, caused by rupture of an atherosclerotic aortic or aortoiliac aneurysm into the inferior vena cava (IVC), iliac, or left renal vein. Two had secondary, iatrogenic arteri


Epididymal mouse spermatozoa have a surface-associated decapacitation factor (DF) that can be removed precociously by centrifugation, resulting in acceleration of capacitation and increased fertilizing ability. Addition of exogenous DF to capacitated suspensions inhibits fertilizing ability and reverses capacitation in acrosome-intact cells. DF appears to regulate a Ca2+-ATPase, located primarily in the post-acrosomal region. The present investigations of DF<-->spermatozoon interaction indicate


The interaction of the tertiary amine drugs chlorpromazine and dibucaine in their cationic form with carboxyl groups at the membrane surface is studied at concentrations relevant to anesthesia. Spin-labeled stearic acid is used both to provide the carboxyl groups and to monitor binding and ionization behavior in egg lecithin liposomes. Membrane anesthetic concentrations are spectrophotometrically obtained. They are shown to determine the drug influence on carboxyl groups at the membrane surface,


UNLABELLED: Overlapping biphasic (OLBI) stimulation is a new pacing waveform consisting of two simultaneous monophasic pulses of opposite polarities applied to a bipolar electrode. The goal of this prospective study was to compare, using conventional pacing leads, the acute energy pacing thresholds, measured at 0.5-ms pulse duration, associated with bipolar versus OLBI (mode 7 and mode 8) pulse delivery. RESULTS: Thirty one leads were tested in 20 patients. Of these leads, 7 (23%) were implanted


All adults over the age of 18 years with Down's syndrome living in a borough of London, England, were identified through a case register. A questionnaire seeking information on health status and screening was sent to their carers. The reply rate was 70%. The attendance for general health care is reasonable, but there are some gaps in screening. The implications for primary health care and health promotion are discussed.


The present study has been designed to examine the role of a hyperglycaemic spike of short duration as a factor possibly involved in haemorheological microcirculatory and (or) haemostatic dysfunctions in ten insulin-dependent diabetes mellitus patients (IDDM) and five healthy volunteers. The hyperglycaemic spike was induced by glucose infusion via GCIIS Biostator. Blood viscosity, erythrocyte aggregation, erythrocyte deformability, plasma viscosity and proteins' levels, cell counts, and transcut


Acquired immunodeficiency syndrome (AIDS) drug assistance programs (ADAPs) provide access to medications for people who lack other health coverage. In this article, the authors present the results of a 1997 survey identifying how 48 States implemented ADAPs, focusing on the number of beneficiaries, medical and financial eligibility criteria, the administration of waiting lists, and the coverage of drugs including protease inhibitors. Increased funding for ADAPs is necessary to maintain this impo


We report on what we believe is the first demonstration of single-mode polymer optical fiber with embedded electrodes. We show that the electrodes can be used to pole the dye-doped core and to electro-optically phase modulate the light in the waveguide.