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glycine - and gaba - activated currents were examined in the axon terminals of 12 types of rabbit cone bipolar cells. in the superfused retinal slice, a cell was voltage clamped at 0 mv in the presence of cobalt ; then glycine or gaba was puffed onto the axon terminal. types cba1, cba2, and a few cba1 - 2 cells demonst... | the distribution of gaba in the perifoveal and the near and far peripheral region of human retina was studied with peroxidase anti - peroxidase immunocytochemistry applied on semithin epoxy resin sections. among the labeled amacrine cells in these regions, four types can be identified : putative diffuse a2 amacrines, s... | indications and perspectives in onco - hematology. bispecific antibodies, currently under active development, are a new and effective therapeutic tool in malignant hematological diseases. those used in clinical practice aim to restore the recognition of tumor cells by immune effector cells, leading to their direct and ... |
patients with primary sjogren's disease ( sjd ) have an increased risk of b cell lymphoma. the aim of this study was to determine serum protein biomarkers for lymphoma development and to advance our understanding of the functional mechanisms underlying lymphomagenesis in sjd. | indications and perspectives in onco - hematology. bispecific antibodies, currently under active development, are a new and effective therapeutic tool in malignant hematological diseases. those used in clinical practice aim to restore the recognition of tumor cells by immune effector cells, leading to their direct and ... | the distribution of gaba in the perifoveal and the near and far peripheral region of human retina was studied with peroxidase anti - peroxidase immunocytochemistry applied on semithin epoxy resin sections. among the labeled amacrine cells in these regions, four types can be identified : putative diffuse a2 amacrines, s... |
in alzheimer's disease ( ad ), hyperactivated microglia produce inflammatory mediators that contribute to neuroinflammation and neuronal damage. amyloid precursor protein ( app ), a transmembrane protein expressed in many cell types, including neurons and microglia, plays a critical role in ad pathogenesis via its secr... | extracellular vesicles ( evs ) have been investigated as nanotherapeutics and drug delivery systems for a wide range of disease indications. however, translational application of evs is challenging due to their physical heterogeneity and variation in functional potency. the current study generated a novel hybrid ev for... | hypoxia occurs in tumors, infections, and sites of inflammation, such as in the affected joints of patients with rheumatoid arthritis ( ra ). it alleviates inflammatory responses and increases bone resorption in inflammatory arthritis by enhancing osteoclastogenesis. the mechanism by which the hypoxia response is linke... |
in alzheimer's disease ( ad ), hyperactivated microglia produce inflammatory mediators that contribute to neuroinflammation and neuronal damage. amyloid precursor protein ( app ), a transmembrane protein expressed in many cell types, including neurons and microglia, plays a critical role in ad pathogenesis via its secr... | people living with hiv - 1 ( pwh ) and chronically using opioids have elevated risks of developing hiv - associated neurological disorders ( hand ) that are often correlated with persistent inflammation. microglia, innate immune cells in the brain, are the principal hiv - 1 reservoir in the central nervous system and r... | monocytes in the circulation of normal individuals express two receptors for the constant region of immunoglobulin, fc gamma ri and fc gamma rii. in contrast, we have observed that aids monocytes express significant levels of a third fc gamma r, fc gamma riii ( cd16 ), which is normally associated with activation or ma... |
human monocyte - derived dendritic cells ( modc ) are commonly used as a research tool to investigate interactions between antigen - presenting cells and t cells. generation of these cells involves the isolation of cd14 positive monocytes from peripheral blood and their in vitro differentiation into immature modc by th... | hypoxia occurs in tumors, infections, and sites of inflammation, such as in the affected joints of patients with rheumatoid arthritis ( ra ). it alleviates inflammatory responses and increases bone resorption in inflammatory arthritis by enhancing osteoclastogenesis. the mechanism by which the hypoxia response is linke... | pretreatment with dithiothreitol ( dtt ) is necessary to dissolve mucus in samples of induced sputum prior to analysis. however, dtt may affect cell surface markers which are essential for lymphocyte subtyping. therefore, the aim of this study was to evaluate the effect of dtt on an appropriate panel of surface markers... |
pemphigus foliaceus ( pf ) is a rare autoimmune blistering disease, occasionally associated with lymphoproliferative disorders. urticarial vasculitis ( uv ) is classified as normocomplementemic or hypocomplementemic ( huv ), the latter linked to systemic involvement and increased risk of malignancy. we present a rare c... | relapsed b - cell acute lymphoblastic leukemia ( b - all ) remains a therapeutic challenge, particularly in children, adolescents, and young adults. blinatumomab, a bispecific t - cell engager targeting cd19 - positive leukemic cells, has emerged as an alternative to conventional chemotherapy in post - induction consol... | indications and perspectives in onco - hematology. bispecific antibodies, currently under active development, are a new and effective therapeutic tool in malignant hematological diseases. those used in clinical practice aim to restore the recognition of tumor cells by immune effector cells, leading to their direct and ... |
pemphigus foliaceus ( pf ) is a rare autoimmune blistering disease, occasionally associated with lymphoproliferative disorders. urticarial vasculitis ( uv ) is classified as normocomplementemic or hypocomplementemic ( huv ), the latter linked to systemic involvement and increased risk of malignancy. we present a rare c... | chimeric antigen receptor ( car ) t ‑ cell therapy represents a novel and highly effective immunotherapeutic approach in the treatment of malignant b ‑ cell neoplasms. although the term b ‑ cell non - hodgkin's lymphoma ( b - nhl ) is still frequently used in clinical practice, the pathologically accurate designation a... | monocytes in the circulation of normal individuals express two receptors for the constant region of immunoglobulin, fc gamma ri and fc gamma rii. in contrast, we have observed that aids monocytes express significant levels of a third fc gamma r, fc gamma riii ( cd16 ), which is normally associated with activation or ma... |
crohn's disease is a lifelong disease characterized by chronic inflammation of the gastrointestinal tract. defining the cellular and transcriptional composition of the mucosa at different stages of disease progression is needed for personalized therapy in crohn's. | genome - wide association studies ( gwas ) have revealed risk alleles for ulcerative colitis ( uc ). to understand their cell type specificities and pathways of action, we generate an atlas of 366, 650 cells from the colon mucosa of 18 uc patients and 12 healthy individuals, revealing 51 epithelial, stromal, and immune... | indications and perspectives in onco - hematology. bispecific antibodies, currently under active development, are a new and effective therapeutic tool in malignant hematological diseases. those used in clinical practice aim to restore the recognition of tumor cells by immune effector cells, leading to their direct and ... |
emerging evidence has shown the importance of inflammasome activation in the progression of autoimmune diseases. in this study, we aimed to identify the main cell types activating inflammasome in autoimmune diseases and to clarify the intracellular pathway of inflammasome activation in systemic lupus erythematosus ( sl... | pretreatment with dithiothreitol ( dtt ) is necessary to dissolve mucus in samples of induced sputum prior to analysis. however, dtt may affect cell surface markers which are essential for lymphocyte subtyping. therefore, the aim of this study was to evaluate the effect of dtt on an appropriate panel of surface markers... | glycine - and gaba - activated currents were examined in the axon terminals of 12 types of rabbit cone bipolar cells. in the superfused retinal slice, a cell was voltage clamped at 0 mv in the presence of cobalt ; then glycine or gaba was puffed onto the axon terminal. types cba1, cba2, and a few cba1 - 2 cells demonst... |
emerging evidence has shown the importance of inflammasome activation in the progression of autoimmune diseases. in this study, we aimed to identify the main cell types activating inflammasome in autoimmune diseases and to clarify the intracellular pathway of inflammasome activation in systemic lupus erythematosus ( sl... | monocytes in the circulation of normal individuals express two receptors for the constant region of immunoglobulin, fc gamma ri and fc gamma rii. in contrast, we have observed that aids monocytes express significant levels of a third fc gamma r, fc gamma riii ( cd16 ), which is normally associated with activation or ma... | the distribution of gaba in the perifoveal and the near and far peripheral region of human retina was studied with peroxidase anti - peroxidase immunocytochemistry applied on semithin epoxy resin sections. among the labeled amacrine cells in these regions, four types can be identified : putative diffuse a2 amacrines, s... |
the improvement of hematopoietic stem and progenitor cell ( hspc ) engraftment remains a high - priority goal when limited cell doses are available, such as in cord blood ( cb ) transplantation and hsc gene therapy. we observed that monocytes are highly effective at improving the engraftment of both cb - cd34 < sup > +... | hypoxia occurs in tumors, infections, and sites of inflammation, such as in the affected joints of patients with rheumatoid arthritis ( ra ). it alleviates inflammatory responses and increases bone resorption in inflammatory arthritis by enhancing osteoclastogenesis. the mechanism by which the hypoxia response is linke... | glycine - and gaba - activated currents were examined in the axon terminals of 12 types of rabbit cone bipolar cells. in the superfused retinal slice, a cell was voltage clamped at 0 mv in the presence of cobalt ; then glycine or gaba was puffed onto the axon terminal. types cba1, cba2, and a few cba1 - 2 cells demonst... |
< i > objective. < / i > restoration of central vision loss in patients with age - related macular degeneration ( amd ) by implanting a retinal prosthesis is associated with an intriguing situation wherein the central prosthetic vision co - exists with natural normal vision. of major interest are the interactions betwe... | glycine - and gaba - activated currents were examined in the axon terminals of 12 types of rabbit cone bipolar cells. in the superfused retinal slice, a cell was voltage clamped at 0 mv in the presence of cobalt ; then glycine or gaba was puffed onto the axon terminal. types cba1, cba2, and a few cba1 - 2 cells demonst... | hypoxia occurs in tumors, infections, and sites of inflammation, such as in the affected joints of patients with rheumatoid arthritis ( ra ). it alleviates inflammatory responses and increases bone resorption in inflammatory arthritis by enhancing osteoclastogenesis. the mechanism by which the hypoxia response is linke... |
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