| { |
| "manifest_version": "1.0", |
| "schema_version": "1.0", |
| "identity": { |
| "namespace": null, |
| "name": "cancer", |
| "version": null, |
| "canonical_id": null |
| }, |
| "display": { |
| "title": "Cancer", |
| "description": "Pathogenic variants in cancer-predisposition genes (ClinVar gene panel)", |
| "report_title": "Cancer Predisposition", |
| "icon": "circle-alert", |
| "color": "#e03997" |
| }, |
| "genome_build": "GRCh38", |
| "curator": "just-dna-seq", |
| "method": "expert-curated", |
| "license": null, |
| "owner": null, |
| "authors": [], |
| "created_at": null, |
| "published_at": null, |
| "stats": { |
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| "study_count": 67116, |
| "gene_count": 319, |
| "genes": [ |
| "ABL1", |
| "ACVR1B", |
| "AIP", |
| "AKT2", |
| "AKT3", |
| "ALK", |
| "AMER1", |
| "ANKRD26", |
| "AP5Z1", |
| "APC", |
| "AR", |
| "ARID1A", |
| "ARID2", |
| "ASXL1", |
| "ATM", |
| "ATR", |
| "ATRX", |
| "AURKA", |
| "AURKB", |
| "AXIN1", |
| "AXIN2", |
| "AXL", |
| "BAP1", |
| "BARD1", |
| "BCORL1", |
| "BLM", |
| "BMPR1A", |
| "BRAF", |
| "BRCA1", |
| "BRCA2", |
| "BRD4", |
| "BRIP1", |
| "BTK", |
| "BUB1B", |
| "CARD11", |
| "CBFB", |
| "CBL", |
| "CCN6", |
| "CCND2", |
| "CD70", |
| "CD79A", |
| "CDC73", |
| "CDH1", |
| "CDK12", |
| "CDK4", |
| "CDK6", |
| "CDK8", |
| "CDKN1A", |
| "CDKN1B", |
| "CDKN1C", |
| "CDKN2A", |
| "CDKN2C", |
| "CEBPA", |
| "CEP57", |
| "CHD2", |
| "CHD4", |
| "CHEK1", |
| "CHEK2", |
| "CSF1R", |
| "CTCF", |
| "CTNNA1", |
| "CTNNB1", |
| "CUL3", |
| "CYLD", |
| "DCLRE1C", |
| "DDB1", |
| "DDB2", |
| "DDR2", |
| "DDX41", |
| "DICER1", |
| "DIS3L2", |
| "DKC1", |
| "DMC1", |
| "DNMT3A", |
| "DOT1L", |
| "EGFR", |
| "ELANE", |
| "EME2", |
| "EP300", |
| "EPCAM", |
| "ERBB2", |
| "ERBB3", |
| "ERBB4", |
| "ERCC1", |
| "ERCC2", |
| "ERCC3", |
| "ERCC4", |
| "ERCC5", |
| "ERCC6", |
| "ERCC8", |
| "ERG", |
| "ESR1", |
| "ETV4", |
| "ETV6", |
| "EXT1", |
| "EZH2", |
| "FANCA", |
| "FANCB", |
| "FANCC", |
| "FANCD2", |
| "FANCE", |
| "FANCF", |
| "FANCG", |
| "FANCI", |
| "FANCL", |
| "FANCM", |
| "FAS", |
| "FAT1", |
| "FBXW7", |
| "FGF10", |
| "FGF14", |
| "FGF23", |
| "FGF3", |
| "FGF4", |
| "FGFR1", |
| "FGFR2", |
| "FGFR3", |
| "FH", |
| "FLCN", |
| "FLT3", |
| "FLT4", |
| "GATA1", |
| "GATA2", |
| "GATA3", |
| "GATA4", |
| "GATA6", |
| "GLI1", |
| "GNA11", |
| "GNAQ", |
| "GNAS", |
| "GPC3", |
| "GRIN2A", |
| "GSK3B", |
| "GTF2H5", |
| "H3-3A", |
| "HGF", |
| "HNF1A", |
| "HOXB13", |
| "HRAS", |
| "IDH1", |
| "IDH2", |
| "IGF1R", |
| "IGF2", |
| "IKZF1", |
| "IL7R", |
| "IRF4", |
| "JAK1", |
| "JAK2", |
| "JAK3", |
| "JUN", |
| "KAT6A", |
| "KDM6A", |
| "KDR", |
| "KEL", |
| "KIT", |
| "KITLG", |
| "KMT2A", |
| "KMT2C", |
| "KMT2D", |
| "KRAS", |
| "LIG4", |
| "LYN", |
| "LZTR1", |
| "MAGI2", |
| "MAP2K1", |
| "MAP2K2", |
| "MAP3K1", |
| "MAX", |
| "MBD4", |
| "MDM2", |
| "MED12", |
| "MEN1", |
| "MET", |
| "MITF", |
| "MLH1", |
| "MLH3", |
| "MRE11", |
| "MSH2", |
| "MSH3", |
| "MSH4", |
| "MSH5", |
| "MSH6", |
| "MTOR", |
| "MUS81", |
| "MUTYH", |
| "MYC", |
| "MYCN", |
| "MYD88", |
| "NBN", |
| "NEIL1", |
| "NF1", |
| "NF2", |
| "NFE2L2", |
| "NFKBIA", |
| "NHEJ1", |
| "NKX2-1", |
| "NOTCH1", |
| "NOTCH2", |
| "NOTCH3", |
| "NPM1", |
| "NRAS", |
| "NSD1", |
| "NSUN2", |
| "NTHL1", |
| "NTRK1", |
| "NTRK2", |
| "NUP93", |
| "PAK3", |
| "PALB2", |
| "PAX5", |
| "PBRM1", |
| "PDGFRA", |
| "PDGFRB", |
| "PHOX2B", |
| "PIK3CA", |
| "PIK3CB", |
| "PIK3CG", |
| "PIK3R1", |
| "PIK3R2", |
| "PKD1", |
| "PLCG2", |
| "PMS1", |
| "PMS2", |
| "PNKP", |
| "POLD1", |
| "POLE", |
| "POLH", |
| "POT1", |
| "PPM1D", |
| "PPP2R1A", |
| "PREX2", |
| "PRF1", |
| "PRKAR1A", |
| "PRKDC", |
| "PRKN", |
| "PTCH1", |
| "PTEN", |
| "PTPN11", |
| "RAC1", |
| "RAD50", |
| "RAD51", |
| "RAD51B", |
| "RAD51C", |
| "RAD51D", |
| "RAD54B", |
| "RAD54L", |
| "RAF1", |
| "RANBP2", |
| "RASA2", |
| "RBBP8", |
| "RHBDF2", |
| "RICTOR", |
| "RIT1", |
| "RNF43", |
| "ROS1", |
| "RPA1", |
| "RRAS", |
| "RUNX1", |
| "RUNX1T1", |
| "SAMD9L", |
| "SBDS", |
| "SDHA", |
| "SDHAF2", |
| "SDHB", |
| "SDHC", |
| "SDHD", |
| "SETD2", |
| "SHOC2", |
| "SLIT2", |
| "SLX4", |
| "SMAD2", |
| "SMAD3", |
| "SMAD4", |
| "SMARCA4", |
| "SMARCB1", |
| "SMO", |
| "SOCS1", |
| "SOS1", |
| "SOS2", |
| "SOX10", |
| "SOX2", |
| "SOX9", |
| "SPEN", |
| "SPOP", |
| "SPRED1", |
| "SPTA1", |
| "SRC", |
| "STAG2", |
| "STAT3", |
| "STAT4", |
| "STK11", |
| "SUFU", |
| "SYK", |
| "TAF1", |
| "TBX3", |
| "TERC", |
| "TERT", |
| "TET2", |
| "TGFBR2", |
| "TINF2", |
| "TMEM127", |
| "TNFAIP3", |
| "TOP1", |
| "TP53", |
| "TSC1", |
| "TSC2", |
| "TSHR", |
| "U2AF1", |
| "UNG", |
| "VEGFA", |
| "VHL", |
| "WRN", |
| "WT1", |
| "XPA", |
| "XPC", |
| "XPO1", |
| "XRCC1", |
| "XRCC2", |
| "XRCC4" |
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| }, |
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| "compile_success": true, |
| "compiled_by": null, |
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| "compiled_at": "2026-07-07T02:35:15Z", |
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