---
license: mit
tags:
  - biology
  - genetics
  - genomics
  - variants
  - annotation
  - longevity
  - pharmacogenomics
language:
  - en
size_categories:
  - 1K<n<10K
---

# Genomic Variant Annotators

Curated genomic variant annotation modules from the [DNA-seq](https://github.com/dna-seq) project.

## Overview

This dataset contains pre-computed annotation data for genetic variants, organized by module:

| Module | Description | Files |
|--------|-------------|-------|
| longevitymap | Longevity-associated variants | annotations.parquet, studies.parquet, weights.parquet |

## Schema

### annotations.parquet
Variant-level facts linking rsIDs to genes and phenotypes.
- `rsid`: dbSNP reference ID
- `module`: Source module name
- `gene`: Associated gene symbol
- `phenotype`: Associated phenotype/trait
- `category`: Functional category

### studies.parquet
Per-study evidence from scientific publications.
- `rsid`: dbSNP reference ID
- `module`: Source module name
- `pmid`: PubMed ID
- `population`: Study population
- `p_value`: Statistical significance
- `conclusion`: Study conclusion
- `study_design`: Type of study

### weights.parquet
Curator-defined scoring for variant impact.
- `rsid`: dbSNP reference ID
- `genotype`: Genotype as list[str] (e.g., ["C", "T"])
- `module`: Source module name
- `weight`: Numeric weight
- `state`: "protective", "risk", or "neutral"
- `priority`: Priority level
- `conclusion`: Curator conclusion
- `curator`: Curator name
- `method`: Curation method

## Usage

```python
import polars as pl

# Load from HuggingFace
weights = pl.read_parquet("hf://datasets/just-dna-seq/annotators/data/longevitymap/weights.parquet")
studies = pl.read_parquet("hf://datasets/just-dna-seq/annotators/data/longevitymap/studies.parquet")
annotations = pl.read_parquet("hf://datasets/just-dna-seq/annotators/data/longevitymap/annotations.parquet")
```

## Statistics

- **Modules**: 1 (longevitymap)
- **Total files**: 3
- **Total size**: 0.10 MB

## License

MIT License - See [LICENSE](LICENSE) for details.

## Citation

If you use this data, please cite the original sources:
- LongevityMap: [https://longevitymap.org/](https://longevitymap.org/)