diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1aeb2efc76ba5801931bab6098220fccb0da1766 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1952f335c43ac711533239a7a5d41a264b7fa1ab3c5510c5242b209a5919cdb1 +size 93627 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7b661840f7137a64387e1b8c176acb01186bbf34 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 55, + "title": "Average number of proteins per term", + "value": 3.0 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b8ab9216b703b9bccb78bb703a9c57d26aeffd0c --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..acf0973a4131fe151d4bf56074213d5ad9322d25 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Histidine acid phosphatase active site [IPR033379] 0.945740956826133 3.673145514395256 0.0002395829584669 0.0130921833889598 0.0010980885596401 2 Q9NPH0 1 +Serine carboxypeptidase, serine active site [IPR018202] 0.9676101546542144 3.5421552723674448 0.000396871786007 0.0215956815441759 0.0015591391593132 3 Q9H3G5,Q9HB40 2 +Beta-ketoacyl synthase, active site [IPR018201] 0.8065927654609134 3.0202390609369503 0.0025257524096522 0.1298521268927083 0.005788182605453 2 P49327 1 +Ubiquitin-conjugating enzyme, active site [IPR023313] 0.3459081780265507 0.1812314734540306 0.8561858913831493 1.0 0.8884947929447775 6 Q16763 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..47cd3ca1ec4c594a00785b55ea5c9c01cdd222f6 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA/RNA non-specific endonuclease, active site [IPR018524]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AMPD2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "AURKB", "BLMH", "BUB1", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CASP3", "CASP7", "CDC42BPB", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CHEK1", "CHEK2", "CHUK", "CIT", "CKB", "CKMT1A*", "CLK3", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "ENDOG", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IKBKB", "IRAK1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MARK2", "MASTL", "MDH1", "MDH2", "MTMR2", "MTMR6", "NEK9", "NME1", "NME3", "OXCT1", "OXSM", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRPF4B", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "RAF1", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SGK3", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TAOK1", "TIGAR", "TOP1", "TPI1", "TPP2", "TRIO", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UBE2T", "ULK3", "UMPS", "UNG", "VRK1", "VRK2", "WNK1", "YES1"], "leading_proteins": ["ACP6", "CPVL", "FASN", "SCPEP1", "UBE2S"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/advanced/plot_0.png b/interpro_binding_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..1fd9fc25a302b0d294261e9bce7b2ec1e86c5dbb --- /dev/null +++ b/interpro_binding_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a0c3408522f4a433abd52ef79ee34a759fd094d766051440c23f14b8c276408d +size 190581 diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..10bc979af933409383c4426079e0a68e358b39dd --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]", "1": "Beta tubulin, autoregulation binding site [IPR013838]", "2": "Protein kinase, ATP binding site [IPR017441]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2d63897a57341b7e728033837ef67be8fa3ca1c5 --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:60b4d2f5931127c50dd7d968e4ec7fc497abea6690a9bf9aafa063a603d6756a +size 135775 diff --git a/interpro_binding_site/basic/plot_1.png b/interpro_binding_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..9331b16b8d0fcd7cd1125d513e45a9bc4eff9a2b --- /dev/null +++ b/interpro_binding_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bc9bc7f7514d0ee86b81e5b42859dc50781436e67de26c62ba0aaba018a4fc99 +size 141652 diff --git a/interpro_binding_site/basic/plot_2.png b/interpro_binding_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..aeed5fc9cd081efc6eb7e5c63368a319dc56bd15 --- /dev/null +++ b/interpro_binding_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cbbaa658e6b10afafd79f333648fbadee1c815f88cb5570f14b0f90d5f79a615 +size 157218 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f78c5304ede6ab9f4ce33b5340a957df44f78bbe --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:45e945e150cc84f62754fd4e8236c28d967cea48842d90534d90fa24aaa0eeaa +size 84001 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..22a8bf5c350f3aeae0720c4a07ab2905013c3307 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +EF-Hand 1, calcium-binding site [IPR018247] 11 41 2.4181380286782743 0.0156001579708635 10.019417475728156 36.70631067961165 0.9532938980945532 0.3894555773109194 3.76037227687173 3.057484685571999 1.1082350706804749 0.3408841825650379 0.0264151659552541 0.0571768496395965 0.0069551143734033 0.000626517772181 0.0004082349616241 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..bfadb7bbaf9b7c4b4416bd46711bebe251ba3b8c --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 31, + "title": "Average number of proteins per term", + "value": 5.32258064516129 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..025bb08dc47b095961ff1a7c897b3215443dd3e0 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e1bd56313af79ca26aa5f93a10cce847c8cfac5e --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EF-Hand 1, calcium-binding site [IPR018247] 0.5396807835520792 2.4181380286782743 0.0156001579708635 0.3857889923007419 0.0268669387275983 41 P80303,Q9NWM8,P41208,Q02818,Q14257,P0DP25,O95302,Q9H223,O95202,Q9Y680,Q9BRK5 11 +Peptidase M16, zinc-binding site [IPR001431] 0.6588818006379357 1.7539882073137452 0.0794325278389533 0.9231357520974964 0.0984963345203022 5 P22695 1 +Beta tubulin, autoregulation binding site [IPR013838] 0.4792640186916025 0.7431283513416749 0.4574039763467816 0.999999994128152 0.5064115452410797 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Protein kinase, ATP binding site [IPR017441] 0.2915321869543723 0.2999810854652363 0.7641915832092154 1.0 0.7641915832092154 59 P54646,P11802,P50750,P06493,Q00535,P51812,P48729,Q15418,O14965 9 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3c8ac0650d33177ce0add05e8e499c8116dfd328 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "APEX1", "ARG2", "AURKA", "AURKB", "BPNT1", "BUB1", "CALM3", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDC42BPB", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CEP97", "CETN2", "CHEK1", "CHUK", "CIT", "CLK3", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "ITSN2", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MARK2", "MCCC1", "METAP2", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "NRDC", "NUCB1", "NUCB2", "OXCT1", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1F", "PPM1G", "PRKAA2", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RAF1", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SGK3", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK4", "TAOK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "ULK3", "UQCRC2", "USP32", "VRK1", "YES1"], "leading_proteins": ["AURKA", "CALM3", "CDK1", "CDK4", "CDK5", "CDK9", "CETN2", "CSNK1A1", "EHD4", "FKBP14", "FKBP7", "FKBP9", "LETM1", "NUCB1", "NUCB2", "PRKAA2", "RCN2", "RPS6KA1", "RPS6KA3", "SDF4", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "UQCRC2"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..a43d921b2e6e292903141acc039439eca8f33f26 --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "ABC transporter-like, conserved site [IPR017871]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..7e584dae7f947ab711930bbe2c7a97a2ae5b1f6b --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f3c604512a037ad13991c3600fb8e41ffef22376ec64f2333e873b630cfcdffc +size 194133 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..d320409eb72c35a5fb8211a20f7a2b0a0c261491 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "ABC transporter-like, conserved site [IPR017871]", "1": "Mini-chromosome maintenance, conserved site [IPR018525]", "2": "Tubulin, conserved site [IPR017975]", "3": "Cullin, conserved site [IPR016157]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..ad25bb04230f00d36c7cb6af07465406e1d8bc5a --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:72190edf3c4f1bff3efbf314fec74143eb8006bfce22963b0dc5e38d995a226b +size 139275 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..d28d43ee41a93d80000288f16a2fb7ba12afdf4b --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b6f4c6624afb176a925ddfd567a71949c48569f8bd7bbcbd49cddf33d4aec972 +size 141354 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..8e164a0405f47d5f29750a24dd44da3905701d72 --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d6f59d172ca1e9d03c7c9b7f2db0221a50b25430825f7e552879ac02278d3a5a +size 136072 diff --git a/interpro_conserved_site/basic/plot_3.png b/interpro_conserved_site/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..8626fec126a28f94c642be64f9f92f492b5d45f3 --- /dev/null +++ b/interpro_conserved_site/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e62ebd96cb194134c2c8925121c4fa94c50f9daae715eebedb76e99d2fa47c93 +size 134442 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..05ffd36952da50212ad267371daa6400e5fcfde8 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3aea9b495e09310e18e8bcda281a4405f3dfccc2271b41c53cdf1eb64e66529e +size 159532 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..16a7377e1504986feefd25a8cdafa3cc370f079c --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Syntaxin/epimorphin, conserved site [IPR006012] 4 5 2.4161011332328526 0.0156877034165099 2.592233009708738 5.847087378640777 0.9961908981999794 0.2839139128702306 1.4759357288864456 1.4239341993278547 1.138258151200134 0.2914162845337057 1.0 1.0 1.0 0.2731207001200411 0.0228394808772788 +ABC transporter-like, conserved site [IPR017871] 5 12 2.0242183600535086 0.042947689297655 2.7694174757281553 10.218446601941748 0.3896442308636141 0.4819689640161482 2.0043003889175366 2.2319066503087304 0.948959154182388 0.2971074262916467 0.1647372735136017 1.0 0.191600110602388 0.0153906222854723 0.0035606647558243 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3c9d34175d31d9dccde3a9df77f907a2c38732cf --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 279, + "title": "Average number of proteins per term", + "value": 2.795698924731183 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8a1c44659541499fd76e30b897d10ad01993d8a9 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c8653cf610225a6cf686f455e90f97546f9e725f --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,46 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Haem oxygenase conserved site [IPR018207] 0.9953325554259038 3.893479058401399 9.881673655409706e-05 0.0271946145646517 0.0009394925706081 2 P30519 1 +Tetraspanin, conserved site [IPR018503] 0.9854142357059504 3.8498930701706993 0.0001181694027019 0.0324335860130375 0.0009394925706081 2 O60637 1 +Lysosome-associated membrane glycoprotein, conserved site [IPR018134] 0.8798133022170291 3.370490542295834 0.0007503448162575 0.1889493588484002 0.0029906600533694 2 P13473 1 +Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728] 0.8462660443407265 3.211937120868166 0.0013184322854995 0.3079418594694945 0.0044858854591996 2 Q07812 1 +Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717] 0.8462660443407265 3.211937120868166 0.0013184322854995 0.3079418594694945 0.0044858854591996 2 Q07812 1 +Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726] 0.8462660443407265 3.211937120868166 0.0013184322854995 0.3079418594694945 0.0044858854591996 2 Q07812 1 +Sterol reductase, conserved site [IPR018083] 0.8748176247446713 3.1269327207416824 0.0017664034522406 0.3893689459349772 0.0055373771143274 3 Q14739,O76062 2 +Sulfatase, conserved site [IPR024607] 0.80892648774796 3.031644698815487 0.0024322531246212 0.4930917327403762 0.0070687356434305 2 P15289 1 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.817830564914116 2.8607520033476623 0.0042263751292332 0.6932301502468303 0.0108699711776361 3 Q8N4Q0 1 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.7969069156696748 2.7607511939049885 0.0057668591168151 0.8008328609155642 0.0131881450294379 3 P55899,P01889 2 +Ribosomal protein S5, N-terminal, conserved site [IPR018192] 0.7077012835472589 2.5213297527983 0.0116912234158104 0.9624119380316488 0.0220395360338588 2 P82675 1 +Syntaxin/epimorphin, conserved site [IPR006012] 0.7967883211678605 2.4161011332328526 0.0156877034165099 0.987863818723079 0.0271855233118402 5 Q9P2W9,O15400,Q13277,Q13190 4 +Polyprenyl synthetase, conserved site [IPR033749] 0.6654025670945091 2.2982555921702055 0.0215472463267627 0.9977058548611254 0.0351560334805076 2 Q5T2R2 1 +4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900] 0.6778523489932653 2.1673299414114813 0.0302097050301848 0.9998080820515708 0.0460574191443801 3 P61221,P21912 2 +Phosphorylase pyridoxal-phosphate attachment site [IPR035090] 0.6178529754959232 2.040402650646746 0.0413102381245356 0.9999922698672212 0.0606608233512917 2 P06737 1 +ABC transporter-like, conserved site [IPR017871] 0.6897100160355712 2.0242183600535086 0.042947689297655 0.9999952020728732 0.0627351063562604 12 O14678,Q03519,Q9NUT2,Q03518,P08183 5 +Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.7006256896226889 1.8283340306122953 0.0674994354626303 0.9999999965951354 0.0896778214003517 6 P42345,Q13315,Q13535 3 +Ras GTPase-activating protein, conserved site [IPR023152] 0.6611142541329272 1.765071914680734 0.0775516801318731 0.9999999998344876 0.1015817782009043 5 P46940,Q86VI3,Q9UJF2 3 +Proteasome beta-type subunit, conserved site [IPR016050] 0.6724964923090697 1.7523484771855982 0.0797139050656428 0.999999999914004 0.103926072492123 8 P20618,P28074,P49721,P28072 4 +Mini-chromosome maintenance, conserved site [IPR018525] 0.6679322429906611 1.6710351782946475 0.0947147295735451 0.9999999999991228 0.1217760808802722 6 P49736,P25205,P33991,P33993,Q14566 5 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.5807498916828673 1.652532898742773 0.0984259642611273 0.9999999999997212 0.1259671744442868 3 P09429 1 +Macrophage migration inhibitory factor, conserved site [IPR019829] 0.5344224037339698 1.570852708733973 0.1162168655607587 0.9999999999999988 0.1427655089626705 2 P14174 1 +Aminotransferase, class IV, conserved site [IPR018300] 0.5145857642940577 1.456501983874542 0.1452539015982679 1.0 0.1717196548555794 2 O15382 1 +ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629] 0.4973428324616366 1.4478620562638749 0.1476556332311025 1.0 0.1738224543100321 22 Q9H8H2 1 +Mrp, conserved site [IPR000808] 0.5090431738623198 1.4244116252149557 0.1543273509458034 1.0 0.1809131551003325 2 Q9Y5Y2 1 +Polyamine biosynthesis domain, conserved site [IPR030373] 0.5014585764294142 1.380414951092378 0.1674589193875311 1.0 0.1954855167745656 2 P52788 1 +EGF-like, conserved site [IPR013032] 0.4967911318553268 1.3532974570667775 0.1759606212664564 1.0 0.2045542222222555 2 O94813 1 +GTP1/OBG, conserved site [IPR006074] 0.4600350058343181 1.1390928764838466 0.2546644183393949 1.0 0.2900056029252701 2 P55039 1 +DNA ligase, ATP-dependent, conserved site [IPR016059] 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.34790930218404 2 P18858 1 +Oxysterol-binding protein, conserved site [IPR018494] 0.520148057215944 0.942400926067132 0.3459874132910716 1.0 0.3861219532328359 6 Q9BXW6 1 +Thioredoxin, conserved site [IPR017937] 0.5002706731047744 0.9173919467193667 0.3589372912536472 1.0 0.3973948581736809 10 O95881,O43396,Q9H1E5 3 +RNA polymerase, beta subunit, conserved site [IPR007121] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.4003459518273291 3 P30876,Q9H9Y6 2 +Malic enzyme, conserved site [IPR015884] 0.4095682613768947 0.8467981158822036 0.3971076586108999 1.0 0.4344824970683964 2 P48163 1 +Tubulin, conserved site [IPR017975] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.4984988648466878 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.4255449494061633 0.7328559069529627 0.4636463185310981 1.0 0.5033358866543828 15 Q7Z478 1 +Cullin, conserved site [IPR016157] 0.4742990654205711 0.7193386235753862 0.4719323036312643 1.0 0.5083749525603195 6 Q13617,Q93034,Q13616,Q13618,Q13620 5 +Ribosomal RNA adenine methylase transferase, conserved site [IPR020596] 0.3710618436406163 0.6311910135065578 0.5279156371009734 1.0 0.5643236120734544 2 Q9UNQ2 1 +Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.387802742923848 0.5982167321275711 0.5496953283552521 1.0 0.5853625824851731 3 Q96CW1,Q9Y2T2 2 +DnaJ domain, conserved site [IPR018253] 0.4312991868759284 0.5783263987213977 0.563043774781665 1.0 0.5950348983488051 11 Q96KC8,O75190,Q9Y2G8 3 +Guanylate kinase, conserved site [IPR020590] 0.4207299270073038 0.5559128746090569 0.5782704165006085 1.0 0.6065317526453751 5 Q9NZW5,Q14168,Q5T2T1,O14936 4 +Ribosomal protein L30, conserved site [IPR018038] 0.3561843640606821 0.5513030777844783 0.5814259289928714 1.0 0.6075574314195172 2 P18124 1 +RIO kinase, conserved site [IPR018935] 0.3535589264877497 0.5374708818974362 0.5909423930393616 1.0 0.6151974912611264 2 Q9BRS2 1 +EGF-like calcium-binding, conserved site [IPR018097] 0.3341114677560595 0.3401680241994275 0.7337299968324789 1.0 0.7526127541039029 3 Q04721,O94813 2 +Short-chain dehydrogenase/reductase, conserved site [IPR020904] 0.3379967639965339 0.1598690740771012 0.8729842104545704 1.0 0.8812634001379618 11 Q6IAN0,Q53GQ0,Q9Y394,Q06136 4 +Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331] 0.2612375948628214 0.0373738066899633 0.9701869573085896 1.0 0.9736768384499872 4 Q7Z628,Q9H8V3,P11274 3 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e83b826a325bf126a0eaea5347bc0af8928d071f --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-2-macroglobulin, conserved site [IPR019742]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Arrestin, conserved site [IPR017864]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "FeS cluster insertion, C-terminal, conserved site [IPR017870]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MnmG-related, conserved site [IPR020595]", "MoaA/NifB/PqqE, iron-sulphur binding, conserved site [IPR000385]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Pyridoxamine 5'-phosphate oxidase, conserved site [IPR019740]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANKRD13A", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APP", "ARHGEF7", "ARIH2", "ARRB2", "ARSA", "ATAD1", "ATAD2", "ATM", "ATP5C1", "ATP5O", "ATR", "BAG6", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT1", "BCAT2", "BCR", "BCS1L", "BDH2", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CDC40", "CDH2", "CDKAL1", "CECR2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CREBBP", "CRYZ", "CSTB", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX31", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC2", "DSG2", "DST", "DTL", "DTYMK", "DUS2", "DUS3L", "DYNLL1", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP2", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNB1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IQGAP3", "ISCA2", "ITGA6", "ITGAV", "IVD", "KATNB1", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MOCS1", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTO1", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NET1", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NOTCH2", "NSD2", "NSF", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NVL", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PDSS1", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF2", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "PNPO", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "POLR3B", "POU2F1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RASAL2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "REL", "RELA", "RIDA", "RIOK1", "RIOK2", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB1", "SERPINB6", "SERPINH1", "SH3RF1", "SHPRH", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STRN", "STX12", "STX18", "STX3", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TM7SF2", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM25", "TRIM27", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TST", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR47", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ABCB1", "ABCB8", "ABCD4", "ABCE1", "AP2M1", "AP3M1", "ARSA", "ATM", "ATR", "BAX", "BCAT2", "BCR", "CASK", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "DDX31", "DHRS7", "DHRS7B", "DHX29", "DIMT1", "DNAJB6", "DNAJC1", "DNAJC16", "DRG2", "ECT2", "FCGRT", "HLA-B", "HMGB1", "HMOX2", "HSD17B12", "IQGAP1", "IQGAP3", "KDSR", "LAMP2", "LBR", "LIG1", "MCM2", "MCM3", "MCM4", "MCM6", "MCM7", "ME1", "MIF", "MPP2", "MPP6", "MPP7", "MRPS5", "MTOR", "NET1", "NOTCH2", "NUBP2", "OSBPL1A", "PDSS1", "POLR1B", "POLR2B", "PSMB1", "PSMB2", "PSMB5", "PSMB6", "PYGL", "RASAL2", "RIOK1", "RPL7", "SDHB", "SLIT2", "SMS", "STX18", "STX3", "STX5", "STX7", "TAP1", "TAP2", "TM7SF2", "TMX4", "TSPAN3", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "TXNDC12", "TXNL1", "ZADH2"]} \ No newline at end of file diff --git a/interpro_domain/advanced/idx2term.json b/interpro_domain/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c81575b17aaae54c205cb061298438649558e394 --- /dev/null +++ b/interpro_domain/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-hand domain [IPR002048]", "1": "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "2": "ABC transporter type 1, transmembrane domain [IPR011527]", "3": "ABC transporter-like, ATP-binding domain [IPR003439]"} \ No newline at end of file diff --git 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type 1, transmembrane domain [IPR011527]", "3": "ABC transporter-like, ATP-binding domain [IPR003439]", "4": "MCM N-terminal domain [IPR027925]", "5": "MCM OB domain [IPR033762]", "6": "MCM domain [IPR001208]", "7": "MCM, AAA-lid domain [IPR041562]", "8": "Importin-beta, N-terminal domain [IPR001494]", "9": "DnaJ domain [IPR001623]", "10": "AP complex, mu/sigma subunit [IPR022775]", "11": "Tubulin/FtsZ, GTPase domain [IPR003008]", "12": "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "13": "Domain of unknown function DUF1605 [IPR011709]", "14": "Helicase-associated domain [IPR007502]", "15": "Cullin homology domain [IPR016158]", "16": "Cullin, N-terminal [IPR001373]", "17": "Cullin protein, neddylation domain [IPR019559]", "18": "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "19": "Thioredoxin domain [IPR013766]", "20": "SNF2, N-terminal [IPR000330]", "21": "TGS [IPR004095]"} \ No newline at end of file diff --git a/interpro_domain/basic/plot_0.png 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@@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bec9ab8bd35beee3cc0c92305955784f507e4eb9dda23b75d9763bde7df4f743 +size 932732 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5cd8b4797bc727c165c705b6b6f686d2daf2ebea --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,15 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +EF-hand domain [IPR002048] 14 49 2.546370899845941 0.0108849465783007 12.385922330097088 43.512135922330096 1.0171858714399242 0.3947118087831401 4.608360476919044 4.087317384177653 1.201458704248258 0.3652478399429377 0.0478917766550272 0.086158736226278 0.0027125023591425 0.000693686312984 9.272076262338654e-05 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 2 5 2.536446892878383 0.0111983726465285 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.0 1.0 1.0 0.4172977923286156 0.0892170338783466 +PIK-related kinase [IPR014009] 3 5 2.4989895222097176 0.0124547993437651 1.7524271844660195 3.3398058252427183 -0.2211924578113137 0.5142924408811651 1.0459672589683773 1.0888080064536276 1.051311965823244 0.3188390843049937 1.0 1.0 1.0 0.1368589802283267 7.736530612306859e-05 +FATC domain [IPR003152] 3 5 2.4989895222097176 0.0124547993437651 1.7524271844660195 3.3398058252427183 -0.2211924578113137 0.5142924408811651 1.0459672589683773 1.0888080064536276 1.051311965823244 0.3188390843049937 1.0 1.0 1.0 0.1368589802283267 7.736530612306859e-05 +PIK-related kinase, FAT [IPR003151] 3 5 2.4989895222097176 0.0124547993437651 1.672330097087379 3.1407766990291264 -0.2139101026296354 0.5194295127936944 0.9838064612370848 0.8974545333648188 1.0476903847911485 0.3181207592603047 1.0 1.0 1.0 0.1154193350298319 2.682481879206317e-05 +GOLD domain [IPR009038] 4 7 2.479966479497288 0.0131394734397018 2.8762135922330097 6.247572815533981 0.4192390492462461 0.3068843884052658 1.4199402534298398 0.930533270242389 1.3963570929114475 0.294203492723015 1.0 1.0 1.0 0.0382400085743442 0.0002504856541451 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 5 7 2.477641840750612 0.0132253829642006 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0040983965897468 0.0573151884822011 0.0056684159955205 0.000142755965642 9.354890231096924e-06 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 1 6 2.3197163068899407 0.0203562291076646 3.0970873786407767 6.975728155339806 0.7379849963606689 0.4199536592827374 1.7349327124234004 0.8151438040285356 0.9001171760244049 0.3234417573977254 1.0 1.0 1.0 1.0 0.0974859568290139 +Dynamin, N-terminal [IPR045063] 1 6 2.3197163068899407 0.0203562291076646 3.0970873786407767 6.975728155339806 0.7379849963606689 0.4199536592827374 1.7349327124234004 0.8151438040285356 0.9001171760244049 0.3234417573977254 1.0 1.0 1.0 1.0 0.0974859568290139 +Linker histone H1/H5, domain H15 [IPR005818] 4 7 2.287591656605523 0.0221613122359809 4.621359223300971 6.101941747572815 -1.4616951902178734 0.1781780847215095 1.4983259581225516 0.4870120076915772 1.3151991134793464 0.2676299008151665 1.0 1.0 1.0 1.0 0.010684483318579 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 2 6 2.229795062353406 0.0257610513544361 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 1.0 1.0 0.0148625463558957 0.0053637976870067 +Aminopeptidase N-like , N-terminal domain [IPR045357] 2 6 2.229795062353406 0.0257610513544361 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 1.0 1.0 0.0148625463558957 0.0053637976870067 +ABC transporter type 1, transmembrane domain [IPR011527] 5 8 2.1190594496623096 0.0340854431078403 2.3689320388349513 6.349514563106796 0.6640264147492347 0.3307390797434538 1.7803691733569 2.1393617497725477 1.1694677427725269 0.279101120079799 0.1154630790463651 1.0 0.1349531130589082 0.0051503840765812 0.0005388274165263 +ABC transporter-like, ATP-binding domain [IPR003439] 5 12 2.0242183600535086 0.042947689297655 2.7694174757281553 10.218446601941748 0.3896442308636141 0.4819689640161482 2.0043003889175366 2.2319066503087304 0.948959154182388 0.2971074262916467 0.1783105780413945 1.0 0.2070995190727305 0.0195244436529747 0.0053032680205866 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c5225712167f580058b3f2cf2015d64aaed86c65 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 2840, + "title": "Average number of proteins per term", + "value": 2.225704225352113 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..48edb0c03967e02397548dd22d9d07ccbcc5ac20 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3113f3f16627ef3880ad3285ce4447c59d6adb15 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,254 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +GMP phosphodiesterase, delta subunit [IPR008015] 0.963827304550755 3.754205102944503 0.0001738924352541 0.389756645692093 0.001742245648349 2 A6NIH7 1 +Reticulon [IPR003388] 0.963243873978994 3.7516030446662167 0.0001757075086425 0.3928947866143302 0.001742245648349 2 O95197 1 +BRICHOS domain [IPR007084] 0.9410735122520426 3.652092855031823 0.0002601117921532 0.5223196915142567 0.0020265957794785 2 Q9Y287 1 +FAD linked oxidase, N-terminal [IPR006094] 0.9404900816802738 3.649457366574109 0.0002627948485121 0.5259466703315409 0.0020265957794785 2 Q15392 1 +FAD-binding domain, PCMH-type [IPR016166] 0.9404900816802738 3.649457366574109 0.0002627948485121 0.5259466703315409 0.0020265957794785 2 Q15392 1 +Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906] 0.9364060676779402 3.6309845452341096 0.0002823420932578 0.5515529947245517 0.0020773356084255 2 P51812 1 +Phospholipase D/Transphosphatidylase [IPR001736] 0.92094515752625 3.560661514009175 0.0003699216888515 0.6503322845898523 0.0024279189279438 2 Q8N2A8 1 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9302597023635772 3.377618926787078 0.0007311632856985 0.8747274146684987 0.0034597763057902 3 Q15629,Q96G23 2 +Cyclin, C-terminal domain [IPR004367] 0.8681446907817975 3.31570080075461 0.0009141364172948 0.9255282012269088 0.0038840671222776 2 P14635 1 +Cyclin, N-terminal [IPR006671] 0.8681446907817975 3.31570080075461 0.0009141364172948 0.9255282012269088 0.0038840671222776 2 P14635 1 +Fatty acid hydroxylase [IPR006694] 0.8608518086347607 3.2812637731305028 0.001033430498835 0.9469468051269562 0.0041290964982982 2 Q15800 1 +WGR domain [IPR008893] 0.838973162193687 3.1770448007374936 0.0014878405038238 0.9854274194827176 0.0051846221237544 2 Q9UGN5 1 +Poly(ADP-ribose) polymerase, regulatory domain [IPR004102] 0.838973162193687 3.1770448007374936 0.0014878405038238 0.9854274194827176 0.0051846221237544 2 Q9UGN5 1 +Sulfatase, N-terminal [IPR000917] 0.80892648774796 3.031644698815487 0.0024322531246212 0.9990082237541544 0.0072482674437821 2 P15289 1 +Polyketide synthase, beta-ketoacyl synthase domain [IPR020841] 0.8065927654609134 3.0202390609369503 0.0025257524096522 0.9992400142764752 0.0074102653341037 2 P49327 1 +Beta-ketoacyl synthase, N-terminal [IPR014030] 0.8065927654609134 3.0202390609369503 0.0025257524096522 0.9992400142764752 0.0074102653341037 2 P49327 1 +Beta-ketoacyl synthase, C-terminal [IPR014031] 0.8065927654609134 3.0202390609369503 0.0025257524096522 0.9992400142764752 0.0074102653341037 2 P49327 1 +MAGE homology domain [IPR002190] 0.8502767940972688 3.013393444647058 0.0025834374620552 0.999355126276813 0.0075560889724376 3 Q9Y5V3 1 +Translation initiation factor IF2/IF5 domain [IPR002735] 0.8039673278879671 3.007388090008897 0.0026350312494796 0.9994432341126952 0.0076675089636496 2 P55010 1 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.7984247374562377 2.980189747417888 0.0028806988323166 0.999723414656356 0.0080893556064015 2 Q15067 1 +Potentiating neddylation domain [IPR005176] 0.8395097753136636 2.963063590563443 0.0030459363642625 0.9998272491996288 0.0083821967318118 3 Q96GG9,Q92564 2 +DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134] 0.8303532785666267 2.9200106751446 0.003500193956347 0.9999526521178056 0.0093163550478215 3 P28340 1 +DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133] 0.8303532785666267 2.9200106751446 0.003500193956347 0.9999526521178056 0.0093163550478215 3 P28340 1 +Tim44-like domain [IPR007379] 0.7838389731621946 2.908167163809919 0.0036355394535851 0.9999678065006778 0.009551278490455 2 Q9BRJ2 1 +Peptidase M28 [IPR007484] 0.7826721120186757 2.9023770956529247 0.0037034244679718 0.9999734704011016 0.0096600754737235 2 Q969V3 1 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.767211201866971 2.8252591624733663 0.0047242387952695 0.9999985567752256 0.0115662398091081 2 Q9NVI7 1 +Diacylglycerol kinase, catalytic domain [IPR001206] 0.7666277712952203 2.822334420689943 0.0047675433772793 0.9999987245378714 0.0116221658295908 2 P52429 1 +ERAP1-like C-terminal domain [IPR024571] 0.8525734467224769 2.8180620442930775 0.0048314472768207 0.9999989371582204 0.0117091954174942 4 P55786,Q9UIQ6 2 +tRNA-guanine(15) transglycosylase-like [IPR002616] 0.7607934655775964 2.793028062780359 0.0052217161709984 0.9999996511163716 0.0124097689754272 2 Q9BXR0 1 +Domain of unknown function DUF3517 [IPR021905] 0.8003438000305952 2.7772628016461858 0.0054818835574386 0.9999998340166548 0.0129296405530493 3 Q9UPU5 1 +N-acetylgalactosaminyltransferase [IPR045885] 0.7990523837978797 2.7710625015887143 0.0055873700730342 0.9999998771899998 0.0131358700392526 3 Q8N4A0 1 +Syntaxin, N-terminal domain [IPR006011] 0.7963233148526375 2.7579440726486317 0.005816614860683 0.999999936193846 0.0135071023747669 3 O15400,Q13277 2 +Cysteine-rich flanking region, C-terminal [IPR000483] 0.7418319719953362 2.697036512579206 0.0069959598961832 0.9999999978077811 0.0152952471941189 2 Q13641 1 +Leucine-rich repeat N-terminal domain [IPR000372] 0.7418319719953362 2.697036512579206 0.0069959598961832 0.9999999978077811 0.0152952471941189 2 Q13641 1 +Legume-like lectin [IPR005052] 0.7403733955659282 2.689604930540643 0.0071536653102888 0.9999999986036808 0.0155443071776742 2 Q12907 1 +Major facilitator superfamily domain [IPR020846] 0.8222416812609421 2.678722717789002 0.0073903565304138 0.9999999992905658 0.0160089202496153 4 Q9H2V7,P53985,Q14728 3 +GINS subunit, domain A [IPR021151] 0.775956731124635 2.6593648065932616 0.0078288142640468 0.9999999997977106 0.0165873891345779 3 Q9Y248 1 +Poly(ADP-ribose) polymerase, catalytic domain [IPR012317] 0.7752723856663527 2.65603149140108 0.0079066230511664 0.9999999998381014 0.0166428966780085 3 Q9UGN5 1 +Exportin-2, central domain [IPR013713] 0.7735628829880266 2.6476988570609628 0.0081041680855331 0.9999999999080345 0.0169358626658676 3 P55060,O15397 2 +RUN domain [IPR004012] 0.765903054055254 2.610257488652334 0.0090474094994041 0.9999999999938316 0.0184720654049661 3 Q9BQS8 1 +Peptidase M14, carboxypeptidase A [IPR000834] 0.72024504084014 2.586346807586156 0.0096999277833762 0.99999999999905 0.0193862033108997 2 Q9UPW5 1 +RAD23A/RAD23B, UBA1 domain [IPR041811] 0.717327887981334 2.571272553093035 0.010132554827346 0.9999999999997252 0.0199421037489001 2 P54725 1 +XPC-binding domain [IPR015360] 0.717327887981334 2.571272553093035 0.010132554827346 0.9999999999997252 0.0199421037489001 2 P54725 1 +SLC12A transporter, C-terminal [IPR018491] 0.7132438739789803 2.55012182195355 0.0107685283534415 0.9999999999999556 0.0208328477682384 2 P55011 1 +Amino acid permease/ SLC12A domain [IPR004841] 0.7132438739789803 2.55012182195355 0.0107685283534415 0.9999999999999556 0.0208328477682384 2 P55011 1 +EF-hand domain [IPR002048] 0.5345966526852118 2.546370899845941 0.0108849465783007 0.9999999999999684 0.0210151245971272 49 P80303,Q9NWM8,P41208,Q02818,O75071,Q14257,Q8IYU8,Q96AY3,P0DP25,O95302,Q9H223,O95202,Q9Y680,Q9BRK5 14 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.8229797690050538 2.536446892878383 0.0111983726465285 0.9999999999999872 0.0214212069964647 5 Q9HD20,P16615 2 +Ribosomal protein S5, C-terminal [IPR005324] 0.7077012835472589 2.5213297527983 0.0116912234158104 0.9999999999999968 0.0220765123011313 2 P82675 1 +Ribosomal protein S5, N-terminal [IPR013810] 0.7077012835472589 2.5213297527983 0.0116912234158104 0.9999999999999968 0.0220765123011313 2 P82675 1 +PIK-related kinase [IPR014009] 0.8147872544573348 2.4989895222097176 0.0124547993437651 0.9999999999999996 0.0231332185507636 5 P42345,Q13315,Q13535 3 +FATC domain [IPR003152] 0.8147872544573348 2.4989895222097176 0.0124547993437651 0.9999999999999996 0.0231332185507636 5 P42345,Q13315,Q13535 3 +PIK-related kinase, FAT [IPR003151] 0.8147872544573348 2.4989895222097176 0.0124547993437651 0.9999999999999996 0.0231332185507636 5 P42345,Q13315,Q13535 3 +Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120] 0.702158693115522 2.492436634354755 0.0126869965977216 0.9999999999999998 0.0234424660621532 2 Q8WVX9 1 +Fatty acyl-CoA reductase, C-terminal [IPR033640] 0.702158693115522 2.492436634354755 0.0126869965977216 0.9999999999999998 0.0234424660621532 2 Q8WVX9 1 +GOLD domain [IPR009038] 0.8333941910167068 2.479966479497288 0.0131394734397018 1.0 0.0240129373029301 7 Q15363,P49755,Q9Y3B3,Q9BQS8 4 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.8328797688425588 2.4776418407506116 0.0132253829642006 1.0 0.0241233703393254 7 Q8WUJ1,Q9UMX5,O43169,O15173,O00264 5 +DNA mismatch repair protein MutS, clamp [IPR007861] 0.6954492415402589 2.457325150763576 0.0139975931327029 1.0 0.0252561400869609 2 P52701 1 +Morc, S5 domain 2-like [IPR041006] 0.6904900816802806 2.431277486776799 0.0150456867296826 1.0 0.0265564064954926 2 Q14149 1 +Condensin complex subunit 1, C-terminal [IPR032682] 0.6887397899649781 2.4220647389812004 0.0154326009535892 1.0 0.0269880460025821 2 P42695 1 +Histidine kinase domain [IPR005467] 0.7221808185322356 2.3932190880980233 0.0167012649505371 1.0 0.0286422659779743 3 Q15120 1 +Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955] 0.7221808185322356 2.3932190880980233 0.0167012649505371 1.0 0.0286422659779743 3 Q15120 1 +RGS domain [IPR016137] 0.7192880070031935 2.378657865638955 0.0173757949660622 1.0 0.0295846868726719 3 O43572,Q9Y5W7 2 +Ribosomal Proteins L2, RNA binding domain [IPR022666] 0.678821470245036 2.369667108146275 0.0178041073892909 1.0 0.0301080689933741 2 P62917 1 +Ribosomal protein L2, C-terminal [IPR022669] 0.678821470245036 2.369667108146275 0.0178041073892909 1.0 0.0301080689933741 2 P62917 1 +Zinc finger, MYND-type [IPR002893] 0.7161818752538982 2.362994917303105 0.01812791822193 1.0 0.0305538799704933 3 Q9H7B4 1 +BTB/POZ domain [IPR000210] 0.7542484003655137 2.35749051043318 0.0183989255558378 1.0 0.0309189044843666 4 Q08380 1 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.7529594112567304 2.3512799897848664 0.0187089499568675 1.0 0.0313286662013584 4 P16615 1 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.7529594112567304 2.3512799897848664 0.0187089499568675 1.0 0.0313286662013584 4 P16615 1 +Ribosomal protein L18e/L15P [IPR021131] 0.7122847971987221 2.3433025753962244 0.0191138750316182 1.0 0.0318938925321949 3 P46776,Q07020 2 +mRNA-decapping enzyme, C-terminal [IPR031953] 0.6700700116686138 2.3231623419223983 0.0201704329523115 1.0 0.0334212541333517 2 Q8IZD4 1 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.8061460569779164 2.3197163068899407 0.0203562291076646 1.0 0.0336701751111052 6 Q9H223 1 +Dynamin, N-terminal [IPR045063] 0.8061460569779164 2.3197163068899407 0.0203562291076646 1.0 0.0336701751111052 6 Q9H223 1 +Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.6662777129521565 2.3029311306877216 0.0212827182817152 1.0 0.0347173577944119 2 P13674 1 +Translation initiation factor IF- 2, domain 3 [IPR023115] 0.6642357059509754 2.292017575745009 0.0219046290021402 1.0 0.0356295225464366 2 O60841 1 +MHC class I, alpha chain, C-terminal [IPR010579] 0.7020116500271805 2.2911725956013185 0.0219534332757982 1.0 0.0356368998575707 3 P01889 1 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.7020116500271805 2.2911725956013185 0.0219534332757982 1.0 0.0356368998575707 3 P01889 1 +Linker histone H1/H5, domain H15 [IPR005818] 0.7912960906444984 2.287591656605523 0.0221613122359809 1.0 0.0358417578304019 7 P16403,P16402,P10412,Q92522 4 +Glycosyltransferase 2-like [IPR001173] 0.7365764356993523 2.271950224331835 0.0230895168994222 1.0 0.0369290380518186 4 Q8N4A0 1 +MHC class I-like antigen recognition-like [IPR011161] 0.7351985558895104 2.265244901918215 0.023497655099937 1.0 0.0374695903895683 4 P55899,P01889 2 +Homeobox domain [IPR001356] 0.7299877171205809 2.2398400930440054 0.0251013059758478 1.0 0.0392986267758587 4 Q96G23 1 +CTP synthase GATase domain [IPR033828] 0.6540256709451626 2.2372417039932597 0.0252705470266334 1.0 0.0395200184777747 2 Q9NRF8 1 +CTP synthase, N-terminal [IPR017456] 0.6540256709451626 2.2372417039932597 0.0252705470266334 1.0 0.0395200184777747 2 Q9NRF8 1 +PIN domain [IPR002716] 0.6912751677852409 2.2363525873088044 0.0253286842725601 1.0 0.0395891377732916 3 Q9ULX3,Q9Y2L1 2 +Tim10-like [IPR004217] 0.6910462185457955 2.2351798134226697 0.025405546202128 1.0 0.0396656136415853 3 Q9Y5L4 1 +Zinc finger, CW-type [IPR011124] 0.6906915669681799 2.2333628290053498 0.0255250273404257 1.0 0.0398302624433016 3 Q14149,Q8NB78 2 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.7864097093954004 2.229795062353406 0.0257610513544361 1.0 0.039978899369726 6 P55786,Q9UIQ6 2 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.7864097093954004 2.229795062353406 0.0257610513544361 1.0 0.039978899369726 6 P55786,Q9UIQ6 2 +ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728] 0.6438156359393296 2.182119501898902 0.0291007142575883 1.0 0.0443080728900355 2 P60842 1 +Ubiquitin system component CUE [IPR003892] 0.6804712915923612 2.1808393753645103 0.0291952990626798 1.0 0.0444106316754208 3 Q9H1I8 1 +DNA mismatch repair protein MutS, core [IPR007696] 0.676101546542173 2.15828725839401 0.030905504750716 1.0 0.0464892126546788 3 P52701,P43246 2 +DNA mismatch repair protein MutS, connector domain [IPR007860] 0.676101546542173 2.15828725839401 0.030905504750716 1.0 0.0464892126546788 3 P52701,P43246 2 +DNA mismatch repair protein MutS-like, N-terminal [IPR007695] 0.676101546542173 2.15828725839401 0.030905504750716 1.0 0.0464892126546788 3 P52701,P43246 2 +DNA mismatch repair protein MutS, C-terminal [IPR000432] 0.676101546542173 2.15828725839401 0.030905504750716 1.0 0.0464892126546788 3 P52701,P43246 2 +ERM family, FERM domain C-lobe [IPR041789] 0.675556626537606 2.1554709460890935 0.0311249998133009 1.0 0.0467698409892988 3 P35241 1 +NAD-dependent epimerase/dehydratase [IPR001509] 0.6324387397899722 2.1202912616135525 0.0339814901407835 1.0 0.0504218557992817 2 Q16795 1 +ABC transporter type 1, transmembrane domain [IPR011527] 0.7476877045950605 2.1190594496623096 0.0340854431078403 1.0 0.050537644974097 8 O14678,Q03519,Q9NUT2,Q03518,P08183 5 +Core histone macro-H2A, macro domain [IPR035796] 0.6318553092182049 2.1171090846598792 0.0342505908587538 1.0 0.0506359594163773 2 Q9P0M6 1 +RasGAP protein, C-terminal [IPR000593] 0.6676393346950764 2.1144522200560414 0.0344766615563574 1.0 0.0508907062474298 3 P46940,Q86VI3 2 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.66647213306098 2.1083893065863593 0.0349973286480533 1.0 0.051498659772265 3 P13674,Q32P28 2 +Longin domain [IPR010908] 0.6524657134519862 2.0353205400780956 0.0418186307429619 1.0 0.0598613464264173 3 O15498,O75396 2 +v-SNARE, coiled-coil homology domain [IPR042855] 0.6524657134519862 2.0353205400780956 0.0418186307429619 1.0 0.0598613464264173 3 O15498,O75396 2 +ABC transporter-like, ATP-binding domain [IPR003439] 0.6897100160355712 2.0242183600535086 0.042947689297655 1.0 0.061292179701176 12 O14678,Q03519,Q9NUT2,Q03518,P08183 5 +CRIB domain [IPR000095] 0.6434594433270973 1.9880331069347648 0.0468080285695136 1.0 0.065646815376503 3 O96013 1 +4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896] 0.6780502043198786 1.9826142454442048 0.0474105349238638 1.0 0.0662627555038254 4 P61221,Q16134,P21912 3 +Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058] 0.6403885644397449 1.9718557385615647 0.0486260772686377 1.0 0.0675369012282909 3 Q5JPH6 1 +Ku70/Ku80 beta-barrel domain [IPR006164] 0.6038506417736387 1.9630613810080444 0.0496390422296448 1.0 0.0686009148088522 2 P12956 1 +Ku70/Ku80 C-terminal arm [IPR005160] 0.6038506417736387 1.9630613810080444 0.0496390422296448 1.0 0.0686009148088522 2 P12956 1 +Ku70/Ku80, N-terminal alpha/beta [IPR005161] 0.6038506417736387 1.9630613810080444 0.0496390422296448 1.0 0.0686009148088522 2 P12956 1 +Coatomer, WD associated region [IPR006692] 0.6032672112018738 1.959825231677778 0.0500162210469525 1.0 0.0690113008980711 2 P53621 1 +CYRIA/CYRIB, Rac1 binding domain [IPR009828] 0.6347261528852045 1.9419552190520315 0.0521425216887352 1.0 0.0714350031818659 3 Q9NUQ9 1 +Macro domain [IPR002589] 0.6320396848555457 1.9277372713292005 0.0538878136430973 1.0 0.0733659591305831 3 Q86WJ1,Q9P0M6 2 +UAS [IPR006577] 0.6247942851347694 1.8892899132329897 0.0588529923814027 1.0 0.0790271859873209 3 O94888 1 +Protein kinase, C-terminal [IPR017892] 0.6960053196626819 1.868445984075278 0.061699932579357 1.0 0.0821463180889712 8 P51812 1 +Glutamine amidotransferase [IPR017926] 0.6544074722708444 1.8631620453939763 0.0624394710358111 1.0 0.0825934316449481 4 P27708,Q9NRF8,P49915 3 +Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403] 0.6935766197953859 1.8565107107068144 0.0633807977910818 1.0 0.0836049538906978 8 P42345,Q9BTU6,Q13315,Q13535 4 +NOPS [IPR012975] 0.612197257076163 1.8220975163169624 0.0684401905286247 1.0 0.0890788914304739 3 Q8WXF1,P23246 2 +Glutathione S-transferase, N-terminal [IPR004045] 0.6772338999605518 1.8091116745980156 0.070433655715673 1.0 0.0912969339262946 9 Q8TB36,Q9H7Z7,O15217,P78417 4 +Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958] 0.6395213076474032 1.7872298573092933 0.073900345489732 1.0 0.0946244279489805 4 Q9NRG0,Q9NRF9,Q9NR33 3 +TATA-binding protein interacting (TIP20) [IPR013932] 0.5720536756126139 1.7851539127229366 0.0742363551354556 1.0 0.0948857953499822 2 O75155 1 +Target SNARE coiled-coil homology domain [IPR000727] 0.6896418194505309 1.7757334762191206 0.0757768569579773 1.0 0.0963754024902174 6 O15400,Q13277,Q13190 3 +Acyltransferase, C-terminal domain [IPR032098] 0.6030462785681658 1.7730172172335965 0.0762258539605382 1.0 0.0969030551691713 3 Q9NUQ2 1 +L27 domain, C-terminal [IPR014775] 0.6258026853473478 1.716782273485265 0.0860189610020918 1.0 0.1064925236468791 4 Q9NZW5,Q14168,O14936 3 +NudC N-terminal domain [IPR025934] 0.5577596266044477 1.7042004312700076 0.0883436486774158 1.0 0.1086600096335474 2 Q9Y266 1 +BRK domain [IPR006576] 0.5892242458846582 1.698471771550752 0.0894187560848065 1.0 0.1096026185933753 3 Q9P2D1 1 +Immunoglobulin C1-set [IPR003597] 0.6440875912408496 1.680265347607893 0.0929056999987181 1.0 0.1129582745346082 5 O15533,P04439,P55899,P01889 4 +Elp3/MiaB/NifB [IPR006638] 0.5843421593880371 1.6720274496646348 0.0945189093752671 1.0 0.1146172940332018 3 Q9H9T3 1 +Radical SAM [IPR007197] 0.5843421593880371 1.6720274496646348 0.0945189093752671 1.0 0.1146172940332018 3 Q9H9T3 1 +MCM N-terminal domain [IPR027925] 0.6679322429906611 1.6710351782946475 0.0947147295735451 1.0 0.1146589224163973 6 P49736,P25205,P33991,P33993,Q14566 5 +MCM OB domain [IPR033762] 0.6679322429906611 1.6710351782946475 0.0947147295735451 1.0 0.1146589224163973 6 P49736,P25205,P33991,P33993,Q14566 5 +MCM domain [IPR001208] 0.6679322429906611 1.6710351782946475 0.0947147295735451 1.0 0.1146589224163973 6 P49736,P25205,P33991,P33993,Q14566 5 +MCM, AAA-lid domain [IPR041562] 0.6679322429906611 1.6710351782946475 0.0947147295735451 1.0 0.1146589224163973 6 P49736,P25205,P33991,P33993,Q14566 5 +RQC domain [IPR018982] 0.5516336056009423 1.669332783520692 0.0950514465778549 1.0 0.1149195863265678 2 P46063 1 +ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284] 0.5516336056009423 1.669332783520692 0.0950514465778549 1.0 0.1149195863265678 2 P46063 1 +Pleckstrin homology domain, spectrin-type [IPR001605] 0.5463827304550848 1.6393671144238964 0.1011368262097227 1.0 0.1208874522035406 2 O15020 1 +Pleckstrin homology domain 9 [IPR041681] 0.5463827304550848 1.6393671144238964 0.1011368262097227 1.0 0.1208874522035406 2 O15020 1 +OTU domain [IPR003323] 0.5452158693115641 1.6326984088416674 0.102532442260091 1.0 0.1222469084881018 2 Q6GQQ9 1 +Gamma-glutamyl cyclotransferase-like [IPR013024] 0.5367561260210104 1.584248658814581 0.1131371441965836 1.0 0.1321717357129977 2 Q8WUX2 1 +bMERB domain [IPR022735] 0.532672112018679 1.5607973836383224 0.1185715649711842 1.0 0.1380970463964868 2 Q8N3F8 1 +Class I myosin tail homology domain [IPR010926] 0.5862006461853276 1.511120291537424 0.1307578056878859 1.0 0.1508948265557075 4 O94832 1 +Class I myosin, motor domain [IPR036072] 0.5862006461853276 1.511120291537424 0.1307578056878859 1.0 0.1508948265557075 4 O94832 1 +ROCK, Rho binding domain [IPR015008] 0.517502917152869 1.4733689985022052 0.1406515648972508 1.0 0.1614593550154375 2 Q13464 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.5887245814409137 1.417004204025363 0.1564816983467083 1.0 0.1786924098530967 11 Q9NWM8,O95302,Q9Y680 3 +RNA recognition motif domain, eukaryote [IPR003954] 0.5514849712901342 1.415415250886677 0.1569467806713267 1.0 0.1790794926101116 14 Q9UHX1 1 +GNAT domain [IPR000182] 0.5869476499607342 1.3916279404365932 0.1640350934614596 1.0 0.1864930606207147 5 Q86UY6 1 +Ricin B, lectin domain [IPR000772] 0.5631352366806974 1.3900181432994974 0.1645233680014388 1.0 0.186973335383788 4 Q8N4A0 1 +Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333] 0.5020420070011735 1.383802473121105 0.1664189455821976 1.0 0.1889936168192978 2 Q9UHQ9 1 +Spermidine synthase, tetramerisation domain [IPR035246] 0.5014585764294142 1.380414951092378 0.1674589193875311 1.0 0.1898536251738875 2 P52788 1 +Polyamine biosynthesis domain [IPR030374] 0.5014585764294142 1.380414951092378 0.1674589193875311 1.0 0.1898536251738875 2 P52788 1 +AGC-kinase, C-terminal [IPR000961] 0.5452342657998641 1.378891520517605 0.1679282029689877 1.0 0.1902337839776326 14 P51812 1 +Glutathione S-transferase, C-terminal [IPR004046] 0.5782945931801641 1.3610807153604163 0.1734881832401074 1.0 0.1964539236052252 11 O15217,P78417 2 +Kinesin-associated [IPR032405] 0.4979579929988517 1.3600796211244437 0.173804729186874 1.0 0.1966555501556662 2 O60333 1 +Kinesin-like KIF1-type [IPR022140] 0.4979579929988517 1.3600796211244437 0.173804729186874 1.0 0.1966555501556662 2 O60333 1 +ZU5 domain [IPR000906] 0.4976662777129679 1.3583842488758695 0.1743417896238059 1.0 0.1971846605064153 2 Q12955 1 +Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099] 0.5185293259410709 1.3107641796016465 0.1899374479612141 1.0 0.2136326147365735 3 Q14558,P11908 2 +Mad3/Bub1 homology region 1 [IPR013212] 0.4862893815635987 1.2921855496080588 0.1962928947627169 1.0 0.220257535016245 2 O43683 1 +Zinc finger, CHHC-type [IPR012996] 0.5132769185876966 1.2816523763890053 0.1999646180156169 1.0 0.2242003612966253 3 P55795,P52597 2 +Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617] 0.5086081120513719 1.2557573197708018 0.2092039701624766 1.0 0.2337290618652374 3 P23193,Q14241 2 +Transcription factor IIS, N-terminal [IPR017923] 0.5086081120513719 1.2557573197708018 0.2092039701624766 1.0 0.2337290618652374 3 P23193,Q14241 2 +Peptidase M16, N-terminal [IPR011765] 0.5778567788665475 1.2502627607849215 0.2112035770623586 1.0 0.2356849347179168 7 P14735,P22695 2 +Peptidase M16, C-terminal [IPR007863] 0.5778567788665475 1.2502627607849215 0.2112035770623586 1.0 0.2356849347179168 7 P14735,P22695 2 +Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543] 0.4687864644107379 1.1901401096026412 0.2339913278189533 1.0 0.2593814875120326 2 Q13555 1 +Domain of unknown function DUF1747 [IPR013719] 0.46849474912486 1.1884384239216377 0.2346607258404631 1.0 0.2600220294135448 2 Q9Y5B9 1 +Glutathione S-transferase, C-terminal-like [IPR010987] 0.5123314951165561 1.1856758984269962 0.2357503161046177 1.0 0.2611274952172833 14 Q8TB36,Q9H7Z7,O15217,P78417 4 +HD/PDEase domain [IPR003607] 0.4647024504084153 1.1663165466830734 0.243486485591525 1.0 0.2692763314174187 2 Q9Y3Z3 1 +HD domain [IPR006674] 0.4647024504084153 1.1663165466830734 0.243486485591525 1.0 0.2692763314174187 2 Q9Y3Z3 1 +GTP binding protein, second domain [IPR031662] 0.4600350058343181 1.1390928764838466 0.2546644183393949 1.0 0.2810909242455816 2 P55039 1 +Cobalamin (vitamin B12)-binding domain [IPR006158] 0.4553675612602189 1.111878269715605 0.2661904930209284 1.0 0.2931295076306463 2 Q99707 1 +Importin-beta, N-terminal domain [IPR001494] 0.4842926649174754 1.0873096765803596 0.2768999735350941 1.0 0.3035105846544451 15 P55060,O95373,Q92973,Q8TEX9,Q96P70,Q96QU8,Q9UI26,O15397 8 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.4413652275379339 1.0303526091633508 0.3028445111868487 1.0 0.3309266686304927 2 O60506 1 +DNA ligase, ATP-dependent, N-terminal [IPR012308] 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.3375394715868729 2 P18858 1 +DNA ligase, ATP-dependent, C-terminal [IPR012309] 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.3375394715868729 2 P18858 1 +DNA ligase, ATP-dependent, central [IPR012310] 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.3375394715868729 2 P18858 1 +CBS domain [IPR000644] 0.5130632162076666 1.0135748387534744 0.3107856688174193 1.0 0.3390823278684098 5 P51798,Q8NE01 2 +Ubiquitin conjugation factor E4, core [IPR019474] 0.4361143523920681 0.9998538868344988 0.3173812232457971 1.0 0.3458797674666399 2 O95155 1 +RNA-binding S4 domain [IPR002942] 0.4614905410142467 0.9944760648029658 0.3199911524897962 1.0 0.3484566231100542 3 P46781 1 +DnaJ domain [IPR001623] 0.4428328052629702 0.9707676976131902 0.3316639716595362 1.0 0.3607528454665196 19 O75190,O75937,O75165,Q96KC8,Q9Y2G8 5 +Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791] 0.4302800466744492 0.9660337788237044 0.3340272787569867 1.0 0.3631843306546103 2 Q9NVE7 1 +FCP1 homology domain [IPR004274] 0.4522906332068964 0.9437490655723376 0.3452978943333522 1.0 0.3745783116526816 3 Q9Y5B0,Q3ZCQ8 2 +IPT domain [IPR002909] 0.4776087711581926 0.9381725801294512 0.3481557271832716 1.0 0.3775342746088168 4 Q96KP1,O15031 2 +Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120] 0.4253208868144725 0.9373542761240172 0.348576352491325 1.0 0.3778461225478485 2 Q9Y305 1 +GAR domain [IPR003108] 0.4206534422403768 0.9104287332880244 0.3625964502090371 1.0 0.3919961623881481 2 Q9UPN3 1 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.3931266048515222 3 P30876,Q9H9Y6 2 +RNA polymerase Rpb2, domain 3 [IPR007645] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.3931266048515222 3 P30876,Q9H9Y6 2 +RNA polymerase, beta subunit, protrusion [IPR007644] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.3931266048515222 3 P30876,Q9H9Y6 2 +RNA polymerase Rpb2, domain 2 [IPR007642] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.3931266048515222 3 P30876,Q9H9Y6 2 +RNA polymerase Rpb2, domain 7 [IPR007641] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.3931266048515222 3 P30876,Q9H9Y6 2 +ELMO domain [IPR006816] 0.415985997666276 0.8835777945514766 0.3769241703521544 1.0 0.4060943261760693 2 Q8IZ81 1 +SLIDE domain [IPR015195] 0.4101516919486642 0.8501343892334928 0.3952503741613637 1.0 0.4240691585259815 2 P28370 1 +ISWI, HAND domain [IPR015194] 0.4101516919486642 0.8501343892334928 0.3952503741613637 1.0 0.4240691585259815 2 P28370 1 +Malic enzyme, N-terminal domain [IPR012301] 0.4095682613768947 0.8467981158822036 0.3971076586108999 1.0 0.4256447539425609 2 P48163 1 +Malic enzyme, NAD-binding [IPR012302] 0.4095682613768947 0.8467981158822036 0.3971076586108999 1.0 0.4256447539425609 2 P48163 1 +Metastasis-associated protein MTA1, R1 domain [IPR035170] 0.4049008168028182 0.8201656424355405 0.4121216853514344 1.0 0.4408382622968262 2 O94776 1 +Alcohol dehydrogenase, N-terminal [IPR013154] 0.4912111297272676 0.8008043229243687 0.4232449360004677 1.0 0.4522255900080242 6 Q8N4Q0 1 +AP complex, mu/sigma subunit [IPR022775] 0.4816004672897331 0.7543619628410384 0.4506319050468295 1.0 0.4805837815745383 6 P53680,P61923,Q92572,P48444,Q9Y2T2 5 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.4872570490715903 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.4872570490715903 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Domain of unknown function DUF1605 [IPR011709] 0.4453545649683697 0.7399067898111287 0.4593565542249824 1.0 0.4889702451270428 13 Q7Z478,Q8IY37,Q92620,Q9H2U1,Q9H6S0 5 +Helicase-associated domain [IPR007502] 0.4453545649683697 0.7399067898111287 0.4593565542249824 1.0 0.4889702451270428 13 Q7Z478,Q8IY37,Q92620,Q9H2U1,Q9H6S0 5 +Polyketide synthase, enoylreductase domain [IPR020843] 0.4751032677958373 0.7361755619284157 0.4616238625435285 1.0 0.4910156440537906 7 Q8N4Q0,Q99536 2 +Cyclin-like [IPR013763] 0.4368345959914511 0.7269007732797789 0.4672867434506274 1.0 0.4968529956569755 4 P14635 1 +Cullin homology domain [IPR016158] 0.4742990654205711 0.7193386235753862 0.4719323036312643 1.0 0.5010421466589872 6 Q13617,Q93034,Q13616,Q13618,Q13620 5 +Cullin, N-terminal [IPR001373] 0.4742990654205711 0.7193386235753862 0.4719323036312643 1.0 0.5010421466589872 6 Q13617,Q93034,Q13616,Q13618,Q13620 5 +Cullin protein, neddylation domain [IPR019559] 0.4742990654205711 0.7193386235753862 0.4719323036312643 1.0 0.5010421466589872 6 Q13617,Q93034,Q13616,Q13618,Q13620 5 +Cold-shock (CSD) domain [IPR019844] 0.4101021987941236 0.7149057878265583 0.474667260385742 1.0 0.5037574811268712 3 P67809 1 +Putative 5-3 exonuclease [IPR004859] 0.3847724620770192 0.7067380682351357 0.4797292677433531 1.0 0.5076121909057835 2 Q8IZH2 1 +Xrn1, helical domain [IPR041412] 0.3847724620770192 0.7067380682351357 0.4797292677433531 1.0 0.5076121909057835 2 Q8IZH2 1 +Dual specificity protein phosphatase domain [IPR020422] 0.4070615698862147 0.698770435643978 0.4846955074124348 1.0 0.512199222871501 3 Q99956,Q9UNI6 2 +Dual specificity phosphatase, catalytic domain [IPR000340] 0.4070615698862147 0.698770435643978 0.4846955074124348 1.0 0.512199222871501 3 Q99956,Q9UNI6 2 +Ribosomal protein S4/S9, N-terminal [IPR001912] 0.3833138856476109 0.6986260758706119 0.4847857433375333 1.0 0.512199222871501 2 P46781 1 +Intermediate filament head, DNA-binding domain [IPR006821] 0.4231269192747898 0.657680553928165 0.510743420453825 1.0 0.5374254590918351 4 P08670,Q16352 2 +Exportin-1/Importin-beta-like [IPR013598] 0.4415404717432855 0.6552702733274486 0.5122937564789236 1.0 0.5388571364444975 5 Q96QU8 1 +Desmoplakin, SH3 domain [IPR041615] 0.4208990075890314 0.6465485503233466 0.5179241655581601 1.0 0.5443762509937731 4 Q15149,Q9UPN3,P15924 3 +Desmoplakin, spectrin-like domain [IPR041573] 0.4208990075890314 0.6465485503233466 0.5179241655581601 1.0 0.5443762509937731 4 Q15149,Q9UPN3,P15924 3 +Threonine-tRNA ligase catalytic core domain [IPR033728] 0.3962649547709461 0.6420221561229151 0.5208587973176027 1.0 0.5472582258164971 3 A2RTX5,Q9BW92 2 +Band 7 domain [IPR001107] 0.4551836923996871 0.6399828754591749 0.5221837325307546 1.0 0.5484474113858517 7 Q9UJZ1,Q99623 2 +CTLH, C-terminal LisH motif [IPR006595] 0.4121424401634618 0.6031603665522436 0.5464020108927083 1.0 0.5730360823247015 4 O94967,Q9NWU2,Q96S59 3 +SMCs flexible hinge [IPR010935] 0.4283211678832161 0.5917688549995053 0.5540053816323971 1.0 0.5807956012683676 5 Q14683,A6NHR9,Q9NTJ3,O95347 4 +SET domain [IPR001214] 0.4368520841736261 0.5906789679260125 0.5547355426821974 1.0 0.5813464727739633 10 Q9H7B4 1 +Glycosyl hydrolase, family 13, catalytic domain [IPR006047] 0.3614352392065308 0.579218216026045 0.5624419410405528 1.0 0.5889878733610509 2 Q04446 1 +Bromo adjacent homology (BAH) domain [IPR001025] 0.4051371862230072 0.5689082454374873 0.5694184094263897 1.0 0.5958541940939376 4 Q86U86,O94776,P26358 3 +Myotubularin-like phosphatase domain [IPR010569] 0.3585180863477231 0.5636695414963923 0.5729790499227096 1.0 0.5989166742123452 2 Q9Y217 1 +Ribosomal protein L30, N-terminal [IPR012988] 0.3561843640606821 0.5513030777844783 0.5814259289928714 1.0 0.6066310206979261 2 P18124 1 +Ribosomal protein L7, eukaryotic/archaeal [IPR035808] 0.3561843640606821 0.5513030777844783 0.5814259289928714 1.0 0.6066310206979261 2 P18124 1 +Ribosomal protein L30, ferredoxin-like fold domain [IPR016082] 0.3561843640606821 0.5513030777844783 0.5814259289928714 1.0 0.6066310206979261 2 P18124 1 +RIO kinase [IPR000687] 0.3535589264877497 0.5374708818974362 0.5909423930393616 1.0 0.6158812463235915 2 Q9BRS2 1 +COMM domain [IPR017920] 0.3743799241319095 0.530169136429588 0.5959946677649743 1.0 0.6209188761748081 3 Q9NX08,Q86X83 2 +Ribosomal protein S7 domain [IPR023798] 0.3506417736289404 0.5222051034985541 0.601527533043452 1.0 0.6262236780950893 2 P46782 1 +Sorting nexin, N-terminal [IPR005329] 0.3500583430571725 0.5191653873964129 0.6036454137626368 1.0 0.6281982319845689 2 O60749 1 +JAB1/MPN/MOV34 metalloenzyme domain [IPR000555] 0.4254821741671469 0.510918265544873 0.6094082905751796 1.0 0.6334991014763947 8 Q7L5N1,P51665,O95630,Q92905,O15372,Q6P2Q9,O00303 7 +Fibronectin type II domain [IPR000562] 0.3474329054842531 0.5055437256397793 0.6131769952450403 1.0 0.6371835589081283 2 Q9UBV2 1 +Thioredoxin domain [IPR013766] 0.3533755451309345 0.4977263723632439 0.6186769173103606 1.0 0.642573009251508 24 O95881,Q9H1E5,P32119,Q9Y2G8,O43396 5 +Mu homology domain [IPR028565] 0.3879159369527211 0.4867294261408997 0.6264500891329274 1.0 0.650262519421606 4 P48444,Q96CW1,Q9Y2T2 3 +SNF2, N-terminal [IPR000330] 0.3758109244141543 0.4661536303927747 0.6411055374910464 1.0 0.6640188645056789 16 Q9P2D1,Q9NRZ9,Q86WJ1,O14646,Q9HCK8,Q9H4L7,O14981,Q2NKX8 8 +Phospholipid/glycerol acyltransferase [IPR002123] 0.4154303573275716 0.4563387692517189 0.6481463891635075 1.0 0.6708220645861375 7 O15228,Q8NF37,Q9NUQ2 3 +Far upstream element-binding protein, C-terminal [IPR015096] 0.3372228704784144 0.4535149160537788 0.6501780050961532 1.0 0.6724346447462036 2 Q96AE4 1 +Ubiquitin-like domain, USP-type [IPR028135] 0.3577473008462383 0.4487871745838809 0.6535851915732982 1.0 0.6754665007526202 3 Q13107,Q9Y4E8 2 +Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346] 0.3577473008462351 0.4487871745838646 0.65358519157331 1.0 0.6754665007526202 3 Q9Y4E8,Q93009 2 +Citron homology (CNH) domain [IPR001180] 0.3771161704611864 0.4369039123082092 0.6621810345218262 1.0 0.6838524138334495 4 O14578,Q9Y5S2,Q8WUH2 3 +TGS [IPR004095] 0.3967280163599119 0.3753413378328764 0.7074066264820424 1.0 0.7277566916526024 7 P55039,Q9Y295,Q9BW92,A2RTX5,Q9NTK5,Q9NYK5 6 +Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263] 0.3211785297549526 0.3751986212471572 0.7075127555115617 1.0 0.7277566916526024 2 O00443 1 +Ras GTPase-activating domain [IPR001936] 0.3921238804448355 0.3515984185576239 0.7251394513796776 1.0 0.745078162777961 6 P46940,Q86VI3,Q9UJF2 3 +LEM domain [IPR003887] 0.3905188967655716 0.3451185316669269 0.7300052621312365 1.0 0.7498064898563153 6 Q86XL3,P42167 2 +EGF-like calcium-binding domain [IPR001881] 0.3341114677560595 0.3401680241994275 0.7337299968324789 1.0 0.7533597942893131 3 Q04721,O94813 2 +MRH domain [IPR044865] 0.3470519556333983 0.3069147162304233 0.7589082873943045 1.0 0.777525085209172 4 P20645,Q13438,P11717 3 +Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615] 0.3579562043795666 0.2840274274062698 0.77638936179601 1.0 0.7940028042854406 5 Q13107,Q86UV5,Q8NFA0,Q9Y4E8 4 +MIT domain [IPR007330] 0.3382953882078297 0.2719057634776723 0.7856944795329104 1.0 0.8020748820537259 4 Q8N0X7,Q6PHR2,O75351 3 +DMAP1-binding domain [IPR010506] 0.2817969661610199 0.2058452369097627 0.8369118038488099 1.0 0.8506905951791769 2 P26358 1 +TOG domain [IPR034085] 0.3453991263196687 0.1791971174704597 0.8577829270189317 1.0 0.8694159574353197 7 Q92616,Q86Y56 2 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.3101479155630491 0.1698898462796632 0.8650967665356042 1.0 0.8755790509483663 4 Q9UKA9 1 +WWE domain [IPR004170] 0.2830463962649669 0.1440902460991764 0.8854292068314711 1.0 0.8948821876873231 3 Q7Z6Z7,Q7Z2W4 2 +Myb domain [IPR017930] 0.3125950661490906 0.0752547992173672 0.9400119844507746 1.0 0.9486972408813787 9 Q96KC8,Q15554 2 +Arf GTPase activating protein [IPR001164] 0.3061906107663186 0.0633963527078726 0.9494508915284754 1.0 0.9578829598368988 7 Q8IYB5,Q15057 2 +OBG-type guanine nucleotide-binding (G) domain [IPR031167] 0.2578102189781069 0.0011484970153545 0.9990836321647756 1.0 1.0 5 A4D1E9,Q9NTK5,Q9Y295,P55039 4 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b553329abf27e78eeccf29cbe79af132ce218bd5 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain [IPR035723]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "3-oxoacid CoA-transferase, subunit A [IPR012792]", "3-oxoacid CoA-transferase, subunit B [IPR012791]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-3' exoribonuclease 1, SH3-like domain [IPR041385]", "5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminal [IPR039148]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "A-kinase anchor protein 10, PKA-binding (AKB) domain [IPR037719]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA lid domain [IPR041083]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC-type uncharacterised transport system [IPR019196]", "ABC1 atypical kinase-like domain [IPR004147]", "ABT1/ESF2, RNA recognition motif [IPR034353]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALG11 mannosyltransferase, N-terminal [IPR031814]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AMPK, C-terminal adenylate sensor domain [IPR032270]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARAP, RhoGAP domain [IPR037858]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ATM, catalytic domain [IPR044107]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Abl Interactor 1, SH3 domain [IPR035725]", "Abl-interactor, homeo-domain homologous domain [IPR012849]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adaptor protein Cbl, EF hand-like [IPR014741]", "Adaptor protein Cbl, N-terminal helical [IPR003153]", "Adaptor protein Cbl, PTB domain [IPR024159]", "Adaptor protein Cbl, SH2-like domain [IPR014742]", "Adaptor protein ClpS, core [IPR003769]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanine racemase, N-terminal [IPR001608]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin [IPR001599]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-2-macroglobulin, TED domain [IPR041813]", "Alpha-2-macroglobulin, bait region domain [IPR011625]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-amylase/branching enzyme, C-terminal all beta [IPR006048]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha-macroglobulin, receptor-binding [IPR009048]", "Alpha-macroglobulin-like, TED domain [IPR011626]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4 long domain [IPR024790]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 1 [IPR041880]", "Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 2 [IPR041882]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Archaeal primase DnaG/twinkle, TOPRIM domain [IPR034154]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginine N-methyltransferase 2-like domain [IPR026480]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Argonaute hook domain [IPR019486]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Arrestin C-terminal-like domain [IPR011022]", "Arrestin-like, N-terminal [IPR011021]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Atg6, BARA domain [IPR040455]", "Atg6/beclin, coiled-coil domain [IPR041691]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "Autophagy-related, C-terminal [IPR015412]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BARD1, Zinc finger, RING-type [IPR039503]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BCAS3 domain [IPR022175]", "BCNT-C domain [IPR011421]", "BCS1, N-terminal [IPR014851]", "BDHCT [IPR012532]", "BEACH domain [IPR000409]", "BEN domain [IPR018379]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCA1, serine-rich domain [IPR025994]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Bcr-Abl oncoprotein oligomerisation [IPR015123]", "Beclin-1, BH3 domain [IPR029318]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Bin3-type S-adenosyl-L-methionine binding domain [IPR024160]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bloom syndrome protein, BDHCT-box associated domain [IPR032439]", "Bloom syndrome protein, N-terminal domain [IPR032437]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brd8, Bromo domain [IPR037966]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C2CD5, C2 domain [IPR037785]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CALCOCO1/2, zinc finger UBZ1-type [IPR041641]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBP/p300-type histone acetyltransferase domain [IPR031162]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCDC93, coiled-coil domain [IPR019159]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not N-terminal domain [IPR007207]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CEP170, C-terminal [IPR029300]", "CFA20 domain [IPR007714]", "CHAT domain [IPR024983]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CISK, PX domain [IPR037900]", "CLASP N-terminal domain [IPR024395]", "CLIP1, zinc knuckle [IPR032108]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "CNOT4, RNA recognition motif [IPR034261]", "COMM domain [IPR017920]", "COMPASS complex Set1 subunit, N-SET domain [IPR024657]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPH domain [IPR021097]", "CPL domain [IPR012959]", "CPPED1, metallophosphatase domain [IPR041867]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CREB-binding protein/p300, atypical RING domain [IPR010303]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CUT domain [IPR003350]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium binding and coiled-coil domain-like [IPR012852]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Calsyntenin, C-terminal [IPR045588]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carbon-nitrogen hydrolase [IPR003010]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cdc6, C-terminal [IPR015163]", "Cell division control protein 73, C-terminal [IPR031336]", "Cell morphogenesis central region [IPR029473]", "Cell morphogenesis protein C-terminal [IPR025481]", "Cell morphogenesis protein N-terminal [IPR025614]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein CENP-B, C-terminal domain [IPR015115]", "Centromere protein Cenp-F, N-terminal [IPR018463]", "Centromere protein Cenp-F, leucine-rich repeat-containing domain [IPR019513]", "Centrosomal CEP44 domain [IPR029157]", "Centrosomal protein of 290kDa, coiled-coil region [IPR032321]", "Centrosomin, N-terminal motif 1 [IPR012943]", "Chaperone DnaJ, C-terminal [IPR002939]", "Checkpoint kinase 1, catalytic domain [IPR034670]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Citron Rho-interacting kinase, catalytic domain [IPR037708]", "Citron homology (CNH) domain [IPR001180]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain [IPR041715]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class V myosin, motor domain [IPR036103]", "Class VI myosin, motor domain [IPR036114]", "Class XVIII myosin, motor domain [IPR036064]", "Classical Protein Kinase C alpha, catalytic domain [IPR034663]", "Classical protein kinase C beta, catalytic domain [IPR034664]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coactivator CBP, KIX domain [IPR003101]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Copper homeostasis CutC domain [IPR023648]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-dependent kinase 11/PITSLRE, catalytic domain [IPR045267]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidine and deoxycytidylate deaminase domain [IPR002125]", "Cytidyltransferase-like domain [IPR004821]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b-c1 complex subunit Rieske, transmembrane domain [IPR004192]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "Cytosolic aminopeptidase 1/4 [IPR033852]", "Cytosolic carboxypeptidase, N-terminal [IPR040626]", "Cytosolic fatty-acid binding [IPR000463]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAMP1, SANT/Myb-like domain [IPR032563]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDB1- and CUL4-associated factor 15, WD40 repeat-containing domain [IPR032734]", "DDE superfamily endonuclease domain [IPR004875]", "DDH domain [IPR001667]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DET1- and DDB1-associated protein 1, N-terminal [IPR018276]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHHA2 domain [IPR004097]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX57, UBA domain [IPR042615]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DIRP domain [IPR033471]", "DJ-1/PfpI [IPR002818]", "DM10 domain [IPR006602]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA binding HTH domain, Psq-type [IPR007889]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA helicase, DnaB-like, C-terminal [IPR007694]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA methyltransferase 1-associated 1 [IPR008468]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase delta subunit 2, C-terminal domain [IPR041863]", "DNA polymerase delta subunit, OB-fold domain [IPR040663]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA recombination and repair protein RecA, monomer-monomer interface [IPR020587]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-binding RFX-type winged-helix domain [IPR003150]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase III subunit RPC5, C-terminal [IPR045576]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding domain, Est1-type [IPR018834]", "DNA/RNA-binding protein Alba-like [IPR002775]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DUS-like, FMN-binding domain [IPR035587]", "DUS2, double-stranded RNA binding domain [IPR044463]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Daxx, N-terminal Rassf1C-interacting domain [IPR031333]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxycytidylate deaminase domain [IPR035105]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "DhaK domain [IPR004006]", "DhaL domain [IPR004007]", "Diacylglycerol kinase, accessory domain [IPR000756]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dienelactone hydrolase [IPR002925]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dip2-like domain [IPR037337]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homolog subfamily C member 16, TRX domain [IPR043361]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DM14 [IPR006608]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF155 [IPR003734]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3498 [IPR021887]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4592 [IPR028030]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5595 [IPR040967]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass [IPR039520]", "E3 ubiquitin-protein ligase SH3RF1, second SH3 domain [IPR035795]", "E3 ubiquitin-protein ligase UBR-like, C-terminal [IPR044046]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELK domain [IPR005539]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELMO, armadillo-like helical domain [IPR024574]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "EXOG, C-terminal [IPR041003]", "EXPERA domain [IPR033118]", "EYA domain [IPR006545]", "EYA domain, metazoan [IPR042577]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin B2, SH3 domain [IPR035640]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "EngB-type guanine nucleotide-binding (G) domain [IPR030393]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Ets domain [IPR000418]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exocyst component Exo84, C-terminal [IPR032403]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease Xrn1, D2/D3 domain [IPR041106]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exostosin, GT47 domain [IPR040911]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "F-box/LRR-repeat protein 18, LRR domain [IPR045627]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain [IPR002938]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM20, C-terminal [IPR009581]", "FAM69, protein-kinase domain [IPR022049]", "FAM83, N-terminal [IPR012461]", "FAM91, C-terminal domain [IPR028097]", "FAM91, N-terminal domain [IPR028091]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FARP1/FARP2/FRMD7, FERM domain C-lobe [IPR041788]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FCP1-like phosphatase, C-terminal [IPR015388]", "FCP1-like phosphatase, phosphatase domain [IPR011947]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FLYWCH-type zinc finger-containing protein, N-terminal [IPR029279]", "FMP27, C-terminal [IPR019443]", "FMP27, GFWDK domain [IPR019441]", "FMP27, N-terminal [IPR019439]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Fanconi anaemia group A protein, N-terminal domain [IPR031729]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Far11/STRP, C-terminal [IPR021819]", "Far11/STRP, N-terminal [IPR012486]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "FeS cluster biogenesis [IPR000361]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "Fibronectin type III and SPRY containing 1, PRY/SPRY domain [IPR035742]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Focadhesin/RST, DUF3730 [IPR022542]", "Folliculin, DENN domain [IPR032035]", "Folliculin/SMCR8, longin domain [IPR037520]", "Folliculin/SMCR8, tripartite DENN domain [IPR037521]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Freud, C2 domain [IPR037772]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fungal lipase-like domain [IPR002921]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G2 and S phase-expressed protein 1, N-terminal [IPR032768]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP-binding protein, middle domain [IPR032305]", "GTP1/OBG domain [IPR006169]", "GTPase HflX, N-terminal [IPR025121]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galactosyltransferase, C-terminal [IPR027791]", "Galactosyltransferase, N-terminal [IPR027995]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-butyrobetaine hydroxylase-like, N-terminal [IPR010376]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gelsolin-like domain [IPR007123]", "Germinal-centre associated nuclear protein, CID domain [IPR031910]", "Germinal-centre associated nuclear protein, MCM3AP domain [IPR031907]", "Germinal-centre associated nuclear protein, nucleoporin homology domain [IPR031908]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 13, N-terminal [IPR004193]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl hydrolases family 38, C-terminal beta sandwich domain [IPR041147]", "Glycosyl transferase 64 domain [IPR015338]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycosyltransferase subfamily 4-like, N-terminal domain [IPR028098]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Golgin subfamily A, conserved domain [IPR043976]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase,subfamily IIIA [IPR006549]", "HAUS augmin-like complex subunit 3, N-terminal [IPR032733]", "HAUS augmin-like complex subunit 6, N-terminal [IPR028163]", "HBS1-like protein, N-terminal [IPR015033]", "HCLS1-binding protein 3, PX domain [IPR037901]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HEPN domain [IPR007842]", "HERC2, APC10 domain [IPR037976]", "HERC2, zinc finger, ZZ-type [IPR041987]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HOOK, N-terminal [IPR043936]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Heparinase II, N-terminal [IPR032518]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "HflX-type guanine nucleotide-binding (G) domain [IPR030394]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histidyl-anticodon-binding [IPR033656]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hook, C-terminal [IPR008636]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Huntingtin-interacting protein 1, clathrin-binding domain [IPR032422]", "Hyaluronan-mediated motility receptor, C-terminal [IPR031794]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxyacylglutathione hydrolase, C-terminal domain [IPR032282]", "Hydroxyacylglutathione hydrolase, MBL domain [IPR035680]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I-kappa-kinase-beta NEMO binding domain [IPR022007]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IKBKB, scaffold dimerization domain [IPR041185]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "INTS6/SAGE1/DDX26B/CT45, C-terminal [IPR029307]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISG20, DEDDh 3'-5' exonuclease domain [IPR037433]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin [IPR013151]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain [IPR040464]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Inositol-tetrakisphosphate 1-kinase, N-terminal [IPR041429]", "Int12, PHD finger [IPR039054]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin alpha-2 [IPR013649]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Interleukin-1 receptor-associated kinase 1, death domain [IPR035533]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intersectin-2, fifth SH3 domain [IPR035741]", "Intersectin-2, first SH3 domain [IPR035737]", "Intersectin-2, fourth SH3 domain [IPR035740]", "Intersectin-2, second SH3 domain [IPR035738]", "Intersectin-2, third SH3 domain [IPR035739]", "Intimal thickness related receptor, IRP [IPR019336]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KAP family P-loop domain [IPR011646]", "KASH domain [IPR012315]", "KELK-motif containing domain [IPR031597]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Katanin p80 subunit, C-terminal [IPR028021]", "Kin17, KOW domain [IPR041995]", "Kinase associated domain 1 (KA1) [IPR001772]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain [IPR018302]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "L27-2 [IPR015132]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIN-9, C-terminal [IPR045831]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV [IPR000034]", "Laminin IV type B [IPR013015]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lipocalin/cytosolic fatty-acid binding domain [IPR000566]", "Liprin-alpha, SAM domain repeat 1 [IPR037620]", "Liprin-alpha, SAM domain repeat 2 [IPR037621]", "Liprin-alpha, SAM domain repeat 3 [IPR037622]", "Liprin-beta, SAM domain repeat 1 [IPR037617]", "Liprin-beta, SAM domain repeat 2 [IPR037618]", "Liprin-beta, SAM domain repeat 3 [IPR037619]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lunapark domain [IPR019273]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAM domain [IPR000998]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MCM3AP, RNA recognition motif [IPR034265]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MPP7, SH3 domain [IPR035599]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTMR6, PH-GRAM domain [IPR035998]", "MYST, zinc finger domain [IPR040706]", "Mab-21 domain [IPR024810]", "Macro domain [IPR002589]", "Macroglobulin domain MG3 [IPR041555]", "Macroglobulin domain [IPR002890]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannose-1-phosphate guanyltransferase, N-terminal domain [IPR045233]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase domain [IPR025714]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Micro-fibrillar-associated protein 1, C-terminal [IPR009730]", "Microspherule protein, N-terminal domain [IPR025999]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MnmG, N-terminal domain [IPR040131]", "MoaB/Mog domain [IPR001453]", "Modifier of rudimentary, Modr [IPR009851]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdenum cofactor synthesis C-terminal [IPR010505]", "Molybdopterin cofactor biosynthesis C (MoaC) domain [IPR002820]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mon2, C-terminal [IPR032817]", "Mon2, dimerisation and cyclophilin-binding domain [IPR032629]", "Morc, S5 domain 2-like [IPR041006]", "Mot1, ATP-binding domain [IPR044078]", "Mot1, central domain [IPR022707]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Mvd1, C-terminal [IPR041431]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin 5a, cargo-binding domain [IPR037988]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myosin-binding domain [IPR026859]", "Myotonic dystrophy protein kinase, coiled coil [IPR014930]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-CoR, GPS2-interacting domain [IPR031557]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-end aminoacyl transferase, N-terminal [IPR007471]", "N-end rule aminoacyl transferase, C-terminal [IPR007472]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NCBP2, RNA recognition motif [IPR034148]", "NDPK7, first NDPk domain [IPR035525]", "NDPK7, second NDPk domain [IPR037993]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NFkappaB IPT domain [IPR033926]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NOT4, modified RING finger, HC subclass (C4C4-type) [IPR039515]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Net1, PH domain [IPR037853]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Neuropilin, C-terminal [IPR022579]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nit1/2, carbon-nitrogen hydrolase domain [IPR045254]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nmd3, N-terminal [IPR007064]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Notch domain [IPR000800]", "Notch, C-terminal [IPR024600]", "Notch, NOD domain [IPR010660]", "Notch, NODP domain [IPR011656]", "Novel protein kinase C delta, catalytic domain [IPR034667]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear receptor coactivator, CREB-bp-like, interlocking [IPR014744]", "Nuclear speckle splicing regulatory protein 1, N-terminal [IPR018612]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NudC domain-containing protein 3, p23 domain [IPR037905]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Opioid growth factor receptor (OGFr) conserved domain [IPR006757]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain [IPR019601]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PHLDB1/2/3, PH domain [IPR037810]", "PHR [IPR012983]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI31 proteasome regulator, C-terminal [IPR013886]", "PI3K p85 subunit, C-terminal SH2 domain [IPR035020]", "PI3K p85 subunit, N-terminal SH2 domain [IPR035022]", "PI3K regulatory subunit p85-related , inter-SH2 domain [IPR032498]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PI4-kinase, N-terminal [IPR045495]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PKHA4-7, PH domain [IPR040392]", "PLAA family ubiquitin binding domain [IPR015155]", "PLAT/LH2 domain [IPR001024]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "PNK, FHA domain [IPR041388]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "POU domain [IPR013847]", "POU domain, class 2, transcription factor 1, C-terminal [IPR045703]", "POU-specific domain [IPR000327]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKAA2, UBA-like autoinhibitory domain [IPR028783]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Par3/HAL, N-terminal [IPR021922]", "Patatin-like phospholipase domain [IPR002641]", "Patatin-like phospholipase domain containing protein 8-like [IPR045217]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C14, p20 domain [IPR001309]", "Peptidase C14, caspase non-catalytic subunit p10 [IPR002138]", "Peptidase C14A, caspase catalytic domain [IPR015917]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S54, rhomboid domain [IPR022764]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif [IPR034168]", "Peptidyl-prolyl cis-trans isomerase like 2, U-box domain [IPR026951]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentrin/AKAP-450 centrosomal targeting domain [IPR019528]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "Persulfide dioxygenase-like, MBL-fold metallo-hydrolase domain [IPR044528]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain [IPR035586]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D-like domain [IPR025202]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Phox-associated domain [IPR003114]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Plus-3 domain [IPR004343]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polynucleotide 3'-phosphatase [IPR006551]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-mRNA-splicing factor 38, C-terminal [IPR024767]", "Pre-mRNA-splicing factor SLU7 domain [IPR021715]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Prokaryote proline-tRNA ligase core domain [IPR033730]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain [IPR039558]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein HGH1 C-terminal [IPR007206]", "Protein HGH1 N-terminal [IPR007205]", "Protein NPAT, C-terminal domain [IPR031442]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein OS9-like domain [IPR012913]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein furry, C-terminal [IPR045842]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Proto-oncogene c-Rel, RHD, N-terminal subdomain [IPR042845]", "Prp18 [IPR004098]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative RNA-binding protein 47, RNA recognition motif 2 [IPR034440]", "Putative RNA-binding protein 47, RNA recognition motif 3 [IPR034445]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine 5'-phosphate oxidase, putative [IPR011576]", "Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal [IPR019576]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM15B, RNA recognition motif 1 [IPR034475]", "RBM15B, RNA recognition motif 2 [IPR034535]", "RBM15B, RNA recognition motif 3 [IPR034536]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM6, OCRE domain [IPR035617]", "RBM6, RNA recognition motif 1 [IPR034123]", "RBM6, RNA recognition motif 2 [IPR034125]", "RBM7, RNA recognition motif [IPR034500]", "RBM8, RNA recognition motif [IPR033744]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RGS domain [IPR016137]", "RGS10, RGS domain [IPR037879]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIO kinase [IPR000687]", "RIO2 kinase winged helix domain, N-terminal [IPR015285]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA methyltransferase bin3, C-terminal [IPR010675]", "RNA polymerase II-associated protein 1, C-terminal [IPR013929]", "RNA polymerase II-associated protein 1, N-terminal [IPR013930]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RWD domain [IPR006575]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rabaptin coiled-coil domain [IPR018514]", "Rabaptin, GTPase-Rab5 binding domain [IPR015390]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raf-like Ras-binding [IPR003116]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap/Ran-GAP domain [IPR000331]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Regulator of G protein signalling-like domain [IPR015212]", "Regulator of MON1-CCZ1 complex, C-terminal [IPR009755]", "Rel homology dimerisation domain [IPR032397]", "Rel homology domain (RHD), DNA-binding domain [IPR011539]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Retinoblastoma-associated protein, A-box [IPR002720]", "Retinoblastoma-associated protein, B-box [IPR002719]", "Retinoblastoma-associated protein, C-terminal [IPR015030]", "Retinoblastoma-associated protein, N-terminal [IPR024599]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho guanine nucleotide exchange factor 7, SH3 domain [IPR035789]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Rhs repeat-associated core [IPR022385]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease H2 subunit B, wHTH domain [IPR019024]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal RNA-processing protein 7, C-terminal domain [IPR024326]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Rieske iron-sulphur protein, C-terminal [IPR005805]", "Right handed beta helix domain [IPR039448]", "RmlD-like substrate binding domain [IPR029903]", "Rnh202, triple barrel domain [IPR041195]", "Roadblock/LAMTOR2 domain [IPR004942]", "Rpa43, N-terminal ribonucleoprotein (RNP) domain [IPR041901]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rrp7, RRM-like N-terminal domain [IPR040447]", "Rrp7A, RNA recognition motif [IPR034890]", "Rubisco LSMT, substrate-binding domain [IPR015353]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SATB, CUT1-like DNA-binding domain [IPR032355]", "SATB, ubiquitin-like oligomerisation domain [IPR032392]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SEPARIN core domain [IPR030397]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SETD2/Set2, SET domain [IPR044437]", "SETD3, SET domain [IPR044428]", "SETD7, SET domain [IPR044436]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3-like domain, bacterial-type [IPR003646]", "SH3RF1/SH3RF3, fourth SH3 domain [IPR035816]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKICH domain [IPR041611]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMAP1-like, ArfGAP domain [IPR044732]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SMYD4, SET domain [IPR044421]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX14, RGS domain [IPR037892]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX8/Mvp1, PX domain [IPR035704]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPIN90, SH3 domain [IPR035514]", "SPIN90/Ldb17, leucine-rich domain [IPR018556]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRA1/Sec31 [IPR009917]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Scm-like with four MBT domains protein 1/2, SAM domain [IPR037604]", "Sde2, N-terminal ubiquitin domain [IPR024974]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec7, C-terminal [IPR015403]", "Sec8 exocyst complex component specific domain [IPR007191]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase MRCK beta, catalytic domain [IPR042718]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase N1, second HR1 domain [IPR037317]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase Rio2 [IPR030484]", "Serine/threonine-protein kinase Sgk3, catalytic domain [IPR037709]", "Serine/threonine-protein kinase greatwall, catalytic domain [IPR037638]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set1A, RNA recognition motif [IPR034467]", "Set2 Rpb1 interacting domain [IPR013257]", "Siah interacting protein, N-terminal [IPR015120]", "Sialidase [IPR011040]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Signal transduction histidine kinase-related protein, C-terminal [IPR004358]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin 4, PX domain [IPR034902]", "Sorting nexin 8/Mvp1, BAR domain [IPR045734]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, C-terminal [IPR013937]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-14, PX domain [IPR037436]", "Sorting nexin-4, BAR domain [IPR037430]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strawberry notch, AAA domain [IPR039187]", "Strawberry notch, helicase C domain [IPR026937]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulfotransferase domain [IPR000863]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Synaptotagmin-like, mitochondrial and lipid-binding domain [IPR040885]", "Synembryn [IPR008376]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "Syntrophin, split Pleckstrin homology (PH) domain [IPR041428]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFA2, Winged helix domain 2 [IPR040501]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIIF beta subunit, HTH domain [IPR040450]", "TFIIF, beta subunit, N-terminal [IPR040504]", "TFIIH p62 subunit, N-terminal [IPR013876]", "TGS [IPR004095]", "THADA/TRM732, DUF2428 [IPR019442]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TNF receptor-associated factor 2, MATH domain [IPR037305]", "TNF receptor-associated factor, BIRC3 binding domain [IPR032070]", "TNRC6, PABC binding domain [IPR032226]", "TNRC6A, RNA recognition motif [IPR034924]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRIM27, PRY/SPRY domain [IPR035791]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUG ubiquitin-like domain [IPR021569]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "TauD/TfdA-like domain [IPR003819]", "Telomerase activating protein Est1, N-terminal [IPR019458]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere repeat-binding factor, dimerisation domain [IPR013867]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Telomere-length maintenance and DNA damage repair [IPR021668]", "Telomeric repeat-binding factor 2, Rap1-binding domain [IPR031902]", "Teneurin intracellular, N-terminal [IPR009471]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tex protein, YqgF-like domain [IPR032639]", "Tex, S1 domain [IPR044146]", "Tex-like protein, N-terminal [IPR018974]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine synthase, N-terminal [IPR029144]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Timeless, C-terminal [IPR007725]", "Timeless, N-terminal [IPR006906]", "Toll/interleukin-1 receptor homology (TIR) domain [IPR000157]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Tox-GHH domain [IPR028916]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor 20, ePHD domain [IPR041972]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor Elf, N-terminal [IPR022084]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFIIB, cyclin-like domain [IPR013150]", "Transcription factor TFIIE beta subunit, DNA-binding domain [IPR003166]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF-2, domain II [IPR044145]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripartite DENN domain [IPR037516]", "Tripeptidyl-peptidase II domain [IPR034051]", "Trm3/ TARBP1, C-terminal [IPR044748]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase Yes, SH3 domain [IPR035751]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-N-acetylglucosamine 2-epimerase domain [IPR003331]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UME domain [IPR012993]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquinol-cytochrome c reductase 8kDa, N-terminal [IPR015248]", "Ubiquinol-cytochrome c reductase, iron-sulphur subunit [IPR006317]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal [IPR032197]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain [IPR032353]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Unconventional myosin-Ie/If, SH3 domain [IPR035507]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Upstream-binding protein 1, SAM domain [IPR037600]", "Uracil-DNA glycosylase-like [IPR005122]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Vacuolar protein sorting-associated, VPS28, C-terminal [IPR017899]", "Vacuolar protein sorting-associated, VPS28, N-terminal [IPR017898]", "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1 [IPR019452]", "Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 [IPR019453]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "Vps72/YL1, C-terminal [IPR013272]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WASH complex subunit 4, N-terminal [IPR028191]", "WASH complex subunit 7, C-terminal [IPR028283]", "WASH complex subunit 7, central domain [IPR028282]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, D1 domain [IPR040992]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "Yippee domain [IPR034751]", "Yippee/Mis18/Cereblon [IPR004910]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "YrdC-like domain [IPR006070]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZCRB1, RNA recognition motif [IPR034219]", "ZN598/Hel2, RING finger [IPR041888]", "ZN622/Rei1/Reh1, zinc finger C2H2-type [IPR041661]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, A20-type [IPR002653]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FLYWCH-type [IPR007588]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TAZ-type [IPR000197]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, TRAF-type [IPR001293]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-finger domain of monoamine-oxidase A repressor R1 [IPR018866]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "bMERB domain [IPR022735]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cDENN domain [IPR001194]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dDENN domain [IPR005112]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA decay factor PAT1 domain [IPR019167]", "mRNA splicing factor Cwf21 domain [IPR013170]", "mRNA-decapping enzyme, C-terminal [IPR031953]", "p115RhoGEF, RGS domain [IPR037887]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal [IPR026904]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNA/rRNA methyltransferase, SpoU type [IPR001537]", "tRNase Z endonuclease [IPR027794]", "uDENN domain [IPR005113]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK4", "AKAP1", "AKAP10", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC4", "ANAPC5", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEH", "APEX1", "APIP", "APMAP", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL8A", "ARL8B", "ARMC10", "ARMC9", "ARMCX3", "ARMT1", "ARRB2", "ARSA", "AS3MT", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG7", "ATIC", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATR", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B4GALT3", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BAP18", "BARD1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCKDHB", "BCKDK", "BCR", "BCS1L", "BECN1", "BEND3", "BIRC6", "BLM", "BLVRA", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRD8", "BRIX1", "BROX", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUD23", "BZW1", "BZW2", "C1orf35", "C2CD2L", "C2CD5", "C3orf58", "CACYBP", "CAD", "CALCOCO1", "CALM3", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CBL", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC93", "CCNB1", "CCNB2", "CD109", "CD2AP", "CD2BP2", "CDC23", "CDC25C", "CDC37", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CEP170", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLPB", "CLPX", "CLSTN3", "CLTC", "CLUH", "CMBL", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT4", "CNPY2", "COA3", "COASY", "COIL", "COMMD2", "COMMD7", "COMMD8", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CREBBP", "CRK", "CRKL", "CROT", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTC", "CWC22", "CWF19L1", "CXADR", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "DAGLB", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF15", "DCP1A", "DCP1B", "DCTD", "DCTN1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DDA1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENND5B", "DENR", "DFFA", "DGKE", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSE", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC2H1", "EARS2", "ECE1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMC1", "EMC7", "EMD", "EML4", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERLIN1", "ERLIN2", "ERP29", "ERP44", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM129B", "FAM208A", "FAM20B", "FAM49B", "FAM83D", "FAM8A1", "FAM91A1", "FANCA", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXL18", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FLYWCH1", "FMR1", "FNDC3A", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GHITM", "GID8", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNB1", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR180", "GPR89B", "GPS1", "GPT2", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTCD", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F2", "GTF2H1", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP6", "GTPBP8", "GTSE1", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS3", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMG20A", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK1", "HP1BP3", "HPRT1", "HS1BP3", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HUWE1", "IAH1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IFT52", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS6", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRGQ", "IRS4", "ISCA2", "ISG20L2", "ISOC1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPK1", "ITSN2", "IVD", "JMJD6", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA1211", "KIAA1468", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KIN", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT4", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8A", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAK16", "MAN2A1", "MAN2B1", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD1", "MBD3", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCRS1", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MEPCE", "METAP2", "METTL13", "METTL25", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD10", "MGME1", "MIA2", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOCS1", "MOCS3", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPDZ", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL16", "MRPL2", "MRPL24", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA40", "NAA50", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCBP1", "NCBP2", "NCKIPSD", "NCL", "NCLN", "NCOR1", "NCSTN", "NDC80", "NDUFA10", "NDUFA2", "NDUFA8", "NDUFA9", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFE", "NEMF", "NENF", "NES", "NET1", "NEU1", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP50", "NUP54", "NUP62", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OXA1L", "OXCT1", "OXSM", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAXBP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNT", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHLDB2", "PI4K2A", "PI4KA", "PICALM", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLAA", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLEKHA7", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "POP1", "POR", "POU2F1", "PPAN", "PPAT", "PPFIA1", "PPFIBP1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPWD1", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAF1", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "REL", "RELA", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMC1", "RMND1", "RNASEH2A", "RNASEH2B", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPP25L", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRP12", "RRP7A", "RSF1", "RTF1", "RTFDC1", "RTN3", "RTN4", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SACS", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SATB2", "SBDS", "SBNO1", "SC5D", "SCAF11", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SCYL1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SGK3", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SH3RF1", "SHCBP1", "SHMT1", "SHMT2", "SHPRH", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A2", "SLC27A4", "SLC2A1", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SLU7", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMS", "SMU1", "SMYD3", "SMYD4", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRA1", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STOML2", "STRBP", "STRIP1", "STRN", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TENM3", "TERF2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THNSL1", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMELESS", "TIMM13", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TJP2", "TKFC", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMLHE", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TP53", "TP53BP1", "TPBG", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSR1", "TST", "TSTA3", "TTC28", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBL7", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UGDH", "UGGT1", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VCP", "VEZT", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS28", "VPS29", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VPS72", "VRK1", "VRK2", "VRK3", "WAPL", "WARS", "WASF2", "WASHC4", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR35", "WDR36", "WDR43", "WDR46", "WDR47", "WDR62", "WFS1", "WNK1", "WWP2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO6", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YBX1", "YES1", "YKT6", "YME1L1", "YPEL5", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMAT2", "ZMPSTE24", "ZMYM2", "ZMYM3", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZYX"], "leading_proteins": ["ABCB1", "ABCB8", "ABCD4", "ABCE1", "ACAP2", "ACOT9", "ACOX1", "AGPAT5", "AGTPBP1", "AKAP10", "ANK3", "ANKLE2", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "ARCN1", "ARSA", "ASCC2", "ATAD3A", "ATM", "ATP13A1", "ATP2A2", "ATR", "BTAF1", "BUB1", "CAD", "CALM3", "CAMK2G", "CAND2", "CASK", "CCNB1", "CDC42BPB", "CERS2", "CETN2", "CHAC2", "CHD1", "CHD1L", "CHD7", "CHD8", "CHRAC1", "CIT", "CLCN7", "CNNM3", "COMMD2", "COMMD8", "COPA", "COPS5", "COPS6", "COPZ1", "CSE1L", "CTDP1", "CTPS2", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYB5R1", "DCP1B", "DCUN1D1", "DCUN1D4", "DGKE", "DHCR24", "DHX29", "DHX36", "DHX37", "DHX38", "DIS3", "DNAAF5", "DNAJB6", "DNAJC1", "DNAJC13", "DNAJC16", "DNAJC8", "DNMT1", "DRG1", "DRG2", "DSP", "DUSP12", "DUSP9", "EARS2", "EFCAB14", "EHD4", "EIF3F", "EIF3H", "EIF4A1", "EIF5", "EIF5B", "ELMOD2", "ELOA", "ELP3", "ERCC6L", "ETFDH", "EXOC2", "FAM49B", "FAR1", "FASN", "FCGRT", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FUBP1", "FYCO1", "GALNT4", "GBE1", "GCN1", "GDAP1", "GID8", "GINS2", "GMPS", "GNPAT", "GSTA4", "GSTO1", "GTPBP10", "H1FX", "H2AFY2", "HELLS", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HLA-A", "HLA-B", "HNRNPF", "HNRNPH2", "HUWE1", "IDE", "IGF2R", "INA", "IPO11", "IPO4", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP3", "ITM2B", "KDM1B", "KIF1B", "LETM1", "LGALS3BP", "LIG1", "LMAN2", "LNPEP", "LPCAT1", "M6PR", "MACF1", "MAGED1", "MCM2", "MCM3", "MCM4", "MCM6", "MCM7", "ME1", "MFSD10", "MICALL1", "MICU2", "MORC3", "MPP2", "MPP6", "MRPL39", "MRPL45", "MRPS5", "MSH2", "MSH6", "MSMO1", "MTA2", "MTMR6", "MTOR", "MTR", "MYO1D", "NAA40", "NCAPD3", "NCLN", "NDUFA9", "NENF", "NOB1", "NOTCH2", "NPEPPS", "NUCB1", "NUCB2", "NUDC", "OLA1", "OS9", "OTUD7B", "P3H1", "P4HA1", "PAK4", "PANK4", "PARP2", "PBRM1", "PDK3", "PGRMC1", "PGRMC2", "PHB2", "PI4K2A", "PIK3C2A", "PLD6", "PLEC", "PLXNB2", "POLD1", "POLE3", "POLE4", "POLR1B", "POLR2B", "PRDX2", "PRPF8", "PRPS2", "PRPSAP1", "PSMD7", "PSPC1", "PTBP2", "PTGES2", "PUF60", "QTRT1", "RAD23A", "RANBP9", "RASAL2", "RCN2", "RDX", "RECQL", "RIOK1", "ROCK1", "RPL18", "RPL27A", "RPL7", "RPL8", "RPS5", "RPS6KA3", "RPS9", "RTN3", "SAMHD1", "SDF4", "SDHB", "SEC22B", "SEL1L", "SFPQ", "SLC12A2", "SLC16A1", "SLIT2", "SMAP1", "SMARCA1", "SMARCAD1", "SMC1A", "SMC2", "SMC4", "SMCHD1", "SMS", "SMYD3", "SNX14", "SNX2", "SPART", "SPNS1", "SPTBN2", "STAMBP", "STOML2", "STX3", "STX5", "STX7", "SUPT16H", "SYNCRIP", "TAP1", "TAP2", "TAPBP", "TARS2", "TARSL2", "TCEA1", "TERF2", "TGFBRAP1", "TIMM13", "TIMM50", "TMED10", "TMED2", "TMED7", "TMPO", "TMX4", "TNPO1", "TPBG", "TRAM1", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "TXNDC12", "TXNL1", "UBE4B", "UBXN7", "ULK3", "UNC119B", "UQCRC2", "USP15", "USP24", "USP32", "USP4", "USP48", "USP7", "VAT1", "VIM", "VPS4B", "WDR47", "XPO6", "XRCC6", "XRN1", "YBX1", "YKT6", "YTHDC2", "ZADH2", "ZC3HAV1"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..f3db11809b301bc6a0997671fae75148aa47cfb0 --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mini-chromosome maintenance protein [IPR031327]", "1": "Beta tubulin [IPR002453]", "2": "Tubulin [IPR000217]", "3": "Cullin [IPR045093]", "4": "Small GTPase [IPR001806]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..45798bb6b696925a7c95e4dd35080f509c60f561 --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e143fe1f8e5259353dafc8204694fd07ee209350e5a66ea6053b694f92cb5119 +size 137551 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..0710e2a55266060cfc0392806a8139453c7371b7 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4c3aa1b81ad7fed093d7ec010b4f105ac9a2446297f8a20692e910f4d1e599bf +size 130807 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..deba61145751fc2b6bd6cc87c9506c46e7286a40 --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b8513c2f67f1a29fb534a5ea0c8e62b51884ec3c3e6d5da710e814513386ae1c +size 127943 diff --git a/interpro_family/basic/plot_3.png b/interpro_family/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..c06fd2e3c56b99d2652a3abf944f9db5f8e2619b --- /dev/null +++ b/interpro_family/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fb935f1d5a0f819946171e78ac97687ff3b0a712a08edb16ad3043f70a8c7b33 +size 127098 diff --git a/interpro_family/basic/plot_4.png b/interpro_family/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..df06f9d23ede161903c1bf5280ea1274cc06ced4 --- /dev/null +++ b/interpro_family/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:98981db479b8007d6affa979df533c730dae3f8bcfda6c07daa9f78e3b5b968e +size 149282 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..015296cee464dbca4132d0fd3ca623aa6ef14ac6 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:403be88eb5b27f6a5c97fa028201f8d899075e61332fc0efdba8e17f4377f8a6 +size 986075 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..86801514c0176a613b70dc076f2c5db93fc700a9 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Transmembrane emp24 domain-containing protein [IPR015720] 3 5 2.61957879646248 0.0088038431088968 2.6432038834951457 5.099514563106796 0.3626508447128717 0.2724944971681708 1.287119696753696 0.8431907483703972 1.4713835809049645 0.2794327521776852 1.0 1.0 1.0 0.0148625463558957 0.0003337445501144 +Linker histone H1/H5 [IPR005819] 4 5 2.609768706577876 0.0090603458503977 4.014563106796117 4.956310679611651 -1.4175513233889876 0.1832168833940027 1.2501578748449933 0.257006630911632 1.3241307402406013 0.2675502959031997 1.0 1.0 1.0 1.0 0.002061539822863 +P-type ATPase [IPR001757] 2 5 2.536446892878383 0.0111983726465285 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.0 1.0 1.0 0.4172977923286156 0.0892170338783466 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 2 6 2.229795062353406 0.0257610513544361 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 1.0 1.0 0.0148625463558957 0.0053637976870067 +Syntaxin [IPR045242] 3 5 2.176470165530324 0.0295201221796768 2.674757281553398 5.815533980582524 0.7134969984167514 0.3462495636510407 1.4434464182805606 1.4295601388514203 1.142372356309129 0.3001529293380739 1.0 1.0 1.0 1.0 0.1467539296032722 +Proteasome B-type subunit [IPR023333] 4 7 2.0940385038718063 0.0362565504255025 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 0.0709501192712976 1.0 0.0832836732680532 0.0188064524051028 0.0077568745967145 +Type 1 protein exporter [IPR039421] 4 6 2.026816802092948 0.0426811514866647 1.4660194174757282 4.152912621359223 0.6118345866928353 0.3423864070958426 1.2012577064447347 1.3414295599134654 1.163285659538929 0.2820720534042253 0.0633191306420368 1.0 0.0743799864466655 0.0148625463558957 0.0003337445501144 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..a497dc3bc627b64d2725d904ac59182786143f7c --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 2616, + "title": "Average number of proteins per term", + "value": 1.2851681957186545 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d4f9dce42cd48a4bb75bd8809f93ff2273dc4d64 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d75a83d655e7ba5c0434ef356903b27cf9523d5b --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,146 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Haem oxygenase-like [IPR016053] 0.9953325554259038 3.893479058401399 9.881673655409706e-05 0.2278043712609567 0.0008722547668414 2 P30519 1 +Haem oxygenase [IPR002051] 0.9953325554259038 3.893479058401399 9.881673655409706e-05 0.2278043712609567 0.0008722547668414 2 P30519 1 +Nucleobindin [IPR040250] 0.9897899649941646 3.869151250360041 0.0001092148784078 0.2485282971558579 0.0008959746700021 2 P80303 1 +Tetraspanin, animals [IPR000301] 0.9854142357059504 3.8498930701706993 0.0001181694027019 0.2659289258800676 0.000908958946229 2 O60637 1 +Tetraspanin/Peripherin [IPR018499] 0.9854142357059504 3.8498930701706993 0.0001181694027019 0.2659289258800676 0.000908958946229 2 O60637 1 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9839556592765456 3.843463427325749 0.0001213100844967 0.2719360791737034 0.0009126654538863 2 O60830 1 +ER lumen protein retaining receptor [IPR000133] 0.9830805134189012 3.839603174610217 0.0001232333337377 0.2755903752677033 0.0009126654538863 2 P24390 1 +CD36 family [IPR002159] 0.97957992998833 3.8241436144544574 0.0001312274109468 0.2905841780424117 0.0009255721270468 2 Q14108 1 +Mitochondrial carrier UCP-like [IPR002030] 0.965285880980161 3.760706556243563 0.0001694340992142 0.3580707332333078 0.0010307897756846 2 Q9UBX3 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9606184364060664 3.7398833171198977 0.0001841056973048 0.3822459290250501 0.0010871794676061 2 Q9Y487 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9606184364060664 3.7398833171198977 0.0001841056973048 0.3822459290250501 0.0010871794676061 2 Q9Y487 1 +Cytochrome P450 [IPR001128] 0.95828471411902 3.7294513704841266 0.0001918971353229 0.3947121074182389 0.0011072209128069 2 Q6UW02 1 +ABC transporter Tap-like [IPR013305] 0.9431155192532056 3.661310221337444 0.000250928699873 0.4813426631467542 0.0012527280131068 2 Q03518 1 +Integral membrane protein 2 [IPR040145] 0.9410735122520426 3.652092855031823 0.0002601117921532 0.4936569932887651 0.0012785283850441 2 Q9Y287 1 +Ribosomal protein S6 kinase II [IPR016239] 0.9364060676779402 3.6309845452341096 0.0002823420932578 0.5222707862796442 0.0013334835478757 2 P51812 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.9676101546542144 3.5421552723674448 0.000396871786007 0.645987362083328 0.0016298533629424 3 Q9H3G5,Q9HB40 2 +Small GTPase superfamily, SAR1-type [IPR006687] 0.9139439906651116 3.5286117245531807 0.0004177455659986 0.6648076474083124 0.0016786826430911 2 Q9NR31 1 +Mpv17/PMP22 [IPR007248] 0.9130688448074632 3.5245964077803107 0.0004241284480741 0.6703604111026845 0.0016913414941493 2 Q567V2 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.9119019836639402 3.5192394966367946 0.0004327858274173 0.6777452149202945 0.0017079544944961 2 O96005 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.9119019836639402 3.5192394966367946 0.0004327858274173 0.6777452149202945 0.0017079544944961 2 O96005 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.9387219142106732 3.4151955905186626 0.0006373622658475 0.8113517790495377 0.0021823817898654 3 Q5VW38,Q9NPR9 2 +Lysosome-associated membrane glycoprotein [IPR002000] 0.8798133022170291 3.370490542295834 0.0007503448162575 0.8596532081440759 0.002420347767361 2 P13473 1 +Histidine phosphatase superfamily, clade-2 [IPR000560] 0.927886640245839 3.3670493442519684 0.0007597709238833 0.8630742081130953 0.0024357361971554 3 Q9NPH0 1 +Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238] 0.8777712952158624 3.36092964330719 0.0007768061035413 0.8690466936386254 0.0024691673959467 2 Q9Y5L4 1 +Cyclin [IPR039361] 0.8681446907817975 3.31570080075461 0.0009141364172948 0.908596778811938 0.0027257479882348 2 P14635 1 +Purine 5'-nucleotidase [IPR016695] 0.8672695449241525 3.3115762548133807 0.0009277195230008 0.9117905092411452 0.0027516034831862 2 P49902 1 +Porin, eukaryotic type [IPR001925] 0.9147942807119812 3.308482257289861 0.0009380312832054 0.914140365215968 0.0027665048893635 3 P21796,P45880 2 +MICOS complex subunit MIC26/MIC27, animal [IPR033182] 0.8305134189031403 3.136376116786927 0.0017104968423446 0.9886494724373373 0.0042134272500694 2 Q9BUR5 1 +MICOS complex subunit MIC26/MIC27 [IPR019166] 0.8305134189031403 3.136376116786927 0.0017104968423446 0.9886494724373373 0.0042134272500694 2 Q9BUR5 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.8748176247446713 3.1269327207416824 0.0017664034522406 0.9901963198708744 0.0043145764995906 3 Q14739,O76062 2 +Nonaspanin (TM9SF) [IPR004240] 0.8165110851808479 3.0686001435348884 0.0021506423356387 0.9964190920069026 0.0050098667409003 2 Q9HD45 1 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.8543915961482227 3.0325441891356477 0.002425015892302 0.998255951232125 0.0054608009878073 3 P12236,P12235 2 +Melanoma-associated antigen [IPR037445] 0.8502767940972688 3.013393444647058 0.0025834374620552 0.998848876954948 0.0057322072949419 3 Q9Y5V3 1 +Translation initiation factor IF2/IF5 [IPR045196] 0.8039673278879671 3.007388090008897 0.0026350312494796 0.9989945697182964 0.0058121768538268 2 P55010 1 +Tricarboxylate/iron carrier [IPR004686] 0.8476801867522549 3.0012848006676713 0.0026884299017424 0.9991259765694404 0.005900111260871 3 Q96NB2,Q6P4A7 2 +Bcl-2 family [IPR026298] 0.8465129851181595 2.99583583841963 0.0027369373323713 0.9992304033228804 0.0059714996342647 3 Q07812,Q9BXK5 2 +Bcl2-like [IPR002475] 0.8465129851181595 2.99583583841963 0.0027369373323713 0.9992304033228804 0.0059714996342647 3 Q07812,Q9BXK5 2 +Acyl-CoA oxidase [IPR012258] 0.7984247374562377 2.980189747417888 0.0028806988323166 0.9994721948501644 0.0061972928826812 2 Q15067 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.7984247374562377 2.980189747417888 0.0028806988323166 0.9994721948501644 0.0061972928826812 2 Q15067 1 +Defective-in-cullin neddylation protein [IPR014764] 0.8395097753136636 2.963063590563443 0.0030459363642625 0.9996578733254896 0.0064734135489863 3 Q96GG9,Q92564 2 +Tumour protein D52 [IPR007327] 0.7911318553092042 2.9442599877683757 0.0032372792865422 0.9997929313298312 0.0067587570738983 2 P55327 1 +Eukaryotic porin/Tom40 [IPR027246] 0.8751075879328145 2.920043308496958 0.0034998274484918 0.9998960507236578 0.0071703268518432 4 P21796,P45880 2 +DNA-directed DNA polymerase, family B [IPR006172] 0.8303532785666267 2.9200106751446 0.003500193956347 0.999896150690572 0.0071703268518432 3 P28340 1 +Dephospho-CoA kinase [IPR001977] 0.7774212368727961 2.876269597515164 0.0040240585227477 0.999973758661731 0.0079508588334654 2 Q8WVC6 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.767211201866971 2.8252591624733663 0.0047242387952695 0.9999958312464108 0.0090605635545638 2 Q9NVI7 1 +Aminopeptidase N-type [IPR034016] 0.8525734467224769 2.8180620442930775 0.0048314472768207 0.9999968550018896 0.0092188665763406 4 P55786,Q9UIQ6 2 +Ribosomal protein S15 [IPR000589] 0.7645857642940488 2.812089395431796 0.0049220821532811 0.9999975217553658 0.0093373219093426 2 P62277 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.8059527283338072 2.804136871816832 0.0050451482642805 0.9999982068083296 0.0094882155710697 3 P28072,P28074 2 +Prenylated rab acceptor PRA1 [IPR004895] 0.7590431738623163 2.7842152047692643 0.0053657419551014 0.9999992282267772 0.0099763901595915 2 O60831 1 +Major facilitator superfamily [IPR011701] 0.8356684179801304 2.740699093979577 0.0061308625894853 0.99999989691406 0.0110532987829729 4 Q96ES6,Q9H2V7,P53985 3 +HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380] 0.7814414940180808 2.6860307214111985 0.0072306440161096 0.9999999943073008 0.0126018419361377 3 Q9H857,P49902 2 +Nucleosome assembly protein (NAP) [IPR002164] 0.8147108359706691 2.643753275175043 0.0081992397578605 0.9999999995570784 0.0138650363326199 4 P55209,Q99733 2 +Transmembrane emp24 domain-containing protein [IPR015720] 0.8412950345207111 2.61957879646248 0.0088038431088968 0.9999999999101458 0.014659995908895 5 Q15363,P49755,Q9Y3B3 3 +Linker histone H1/H5 [IPR005819] 0.8391240875912286 2.6097687065778756 0.0090603458503977 0.9999999999543442 0.0149822153885211 5 P16403,P16402,P10412,Q92522 4 +Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276] 0.7205367561260223 2.5878527040673953 0.0096576268022428 0.99999999999057 0.0157803570984804 2 O43819 1 +Copper chaperone SCO1/SenC [IPR003782] 0.7205367561260223 2.5878527040673953 0.0096576268022428 0.99999999999057 0.0157803570984804 2 O43819 1 +UV excision repair protein Rad23 [IPR004806] 0.717327887981334 2.571272553093035 0.010132554827346 0.9999999999973112 0.0163723060088557 2 P54725 1 +SLC12A transporter family [IPR004842] 0.7132438739789803 2.55012182195355 0.0107685283534415 0.9999999999994996 0.01725074719694 2 P55011 1 +Ribosomal protein L15 [IPR030878] 0.7120770128354733 2.5440687159937196 0.0109569527169357 0.999999999999696 0.0174719856158751 2 P46776 1 +P-type ATPase [IPR001757] 0.8229797690050538 2.536446892878383 0.0111983726465285 0.9999999999998396 0.0177652776490713 5 Q9HD20,P16615 2 +Ribosomal protein S5 [IPR000851] 0.7077012835472589 2.5213297527983 0.0116912234158104 0.9999999999999564 0.0183910044833193 2 P82675 1 +Membrane bound O-acyl transferase, MBOAT [IPR004299] 0.706242707117843 2.5137361097618114 0.0119459783845208 0.9999999999999778 0.0187017830364491 2 Q96N66 1 +Fatty acyl-CoA reductase [IPR026055] 0.702158693115522 2.492436634354755 0.0126869965977216 0.9999999999999968 0.0195851707466833 2 Q8WVX9 1 +Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971] 0.6887397899649781 2.4220647389812004 0.0154326009535892 1.0 0.0230038086009056 2 P42695 1 +PDK/BCKDK protein kinase [IPR039028] 0.7221808185322356 2.3932190880980233 0.0167012649505371 1.0 0.0245039310771762 3 Q15120 1 +Oligosaccharyl transferase, STT3 subunit [IPR003674] 0.6817386231038478 2.385112095488594 0.0170739179465939 1.0 0.0249179905211436 2 P46977 1 +Luc7-related [IPR004882] 0.7192491703860389 2.378462207288918 0.0173850189289308 1.0 0.0252662275100461 3 Q9NQ29 1 +Ribosomal protein L2 [IPR002171] 0.678821470245036 2.369667108146275 0.0178041073892909 1.0 0.0257567724235636 2 P62917 1 +Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129] 0.6770711785297621 2.3603865362647434 0.0182559019865009 1.0 0.0262547771284697 2 Q99735 1 +Flotillin family [IPR027705] 0.6724037339556462 2.335588528030205 0.0195126970595655 1.0 0.0277813974379827 2 O75955 1 +mRNA-decapping enzyme subunit 1 [IPR010334] 0.6700700116686138 2.3231623419223983 0.0201704329523115 1.0 0.0285684096390076 2 Q8IZD4 1 +Prolyl 4-hydroxylase [IPR045054] 0.6662777129521565 2.3029311306877216 0.0212827182817152 1.0 0.029677820375782 2 P13674 1 +Translation initiation factor IF- 2 [IPR015760] 0.6642357059509754 2.292017575745009 0.0219046290021402 1.0 0.0303992092676917 2 O60841 1 +Integral membrane protein EMC3/TMCO1-like [IPR002809] 0.6584014002333571 2.260759533005184 0.0237741517235898 1.0 0.0325960067656766 2 Q9UM00 1 +CTP synthase [IPR004468] 0.6540256709451626 2.2372417039932597 0.0252705470266334 1.0 0.034270477460691 2 Q9NRF8 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.7864097093954004 2.229795062353406 0.0257610513544361 1.0 0.0347196859058243 6 P55786,Q9UIQ6 2 +Synaptobrevin [IPR001388] 0.6522753792298788 2.2278167544402083 0.0258927371271235 1.0 0.0348791968715526 2 O75396 1 +Vacuolar protein sorting-associated protein 33 [IPR027121] 0.647316219369901 2.2010574943316548 0.0277319538878824 1.0 0.0369194867026465 2 Q9H267 1 +Syntaxin [IPR045242] 0.7457254543135872 2.176470165530324 0.0295201221796768 1.0 0.0388453921640012 5 O15400,Q13277,Q13190 3 +DNA mismatch repair MutS family [IPR045076] 0.676101546542173 2.15828725839401 0.030905504750716 1.0 0.0404041981148791 3 P52701,P43246 2 +Ezrin/radixin/moesin [IPR011174] 0.675556626537606 2.1554709460890935 0.0311249998133009 1.0 0.0406267265346832 3 P35241 1 +FAM98 [IPR018797] 0.6368144690781867 2.1441218889622893 0.0320231216294977 1.0 0.0415332107995865 2 Q52LJ0 1 +Core histone macro-H2A [IPR021171] 0.6318553092182049 2.1171090846598792 0.0342505908587538 1.0 0.0438319948893234 2 Q9P0M6 1 +Proteasome B-type subunit [IPR023333] 0.7498666276299767 2.0940385038718063 0.0362565504255025 1.0 0.0458198724217945 7 P20618,P28074,P49721,P28072 4 +Glycogen/starch/alpha-glucan phosphorylase [IPR011833] 0.6178529754959232 2.040402650646746 0.0413102381245356 1.0 0.0510716365471574 2 P06737 1 +Glycosyl transferase, family 35 [IPR000811] 0.6178529754959232 2.040402650646746 0.0413102381245356 1.0 0.0510716365471574 2 P06737 1 +Type 1 protein exporter [IPR039421] 0.7425834386314556 2.026816802092948 0.0426811514866647 1.0 0.0524936023926257 6 Q03518,Q03519,Q9NUT2,P08183 4 +Glutamyl/glutaminyl-tRNA synthetase [IPR000924] 0.6403885644397449 1.9718557385615647 0.0486260772686377 1.0 0.0584585561281049 3 Q5JPH6 1 +Zinc finger CCCH domain-containing protein A/B [IPR039691] 0.5816802800466778 1.8393404594140117 0.0658651256334201 1.0 0.075406200725176 2 Q8IWR0 1 +Isocitrate dehydrogenase NADP-dependent [IPR004790] 0.5808051341890417 1.834425805833712 0.0665908118865603 1.0 0.0761037850132118 2 O75874 1 +Mitochondrial carrier protein [IPR002067] 0.6707029137139554 1.8114652576283643 0.0700688623224325 1.0 0.0792135453048762 10 P12235,P12236,O43808,Q9BQT8 4 +Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852] 0.5720536756126139 1.7851539127229366 0.0742363551354556 1.0 0.0830989751965562 2 O75155 1 +Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081] 0.5932302305223242 1.7201267821934478 0.0854093983941606 1.0 0.0934696552612423 3 Q92688,Q9BTT0 2 +Mini-chromosome maintenance protein [IPR031327] 0.6679322429906611 1.6710351782946475 0.0947147295735451 1.0 0.1023858399026421 6 P49736,P25205,P33991,P33993,Q14566 5 +DNA helicase, ATP-dependent, RecQ type [IPR004589] 0.5516336056009423 1.669332783520692 0.0950514465778549 1.0 0.1026226100898342 2 P46063 1 +Spectrin, beta subunit [IPR016343] 0.5463827304550848 1.6393671144238964 0.1011368262097227 1.0 0.108431941542883 2 O15020 1 +Macrophage migration inhibitory factor [IPR001398] 0.5344224037339698 1.570852708733973 0.1162168655607587 1.0 0.1221467739280613 2 P14174 1 +Target of Myb protein 1 [IPR014645] 0.5180863477246302 1.4767404420916128 0.1397452269137331 1.0 0.1452994887147559 2 Q6ZVM7 1 +Rho-associated protein kinase 1/2 [IPR020684] 0.517502917152869 1.4733689985022052 0.1406515648972508 1.0 0.1461256925223225 2 Q13464 1 +Branched-chain aminotransferase [IPR033939] 0.5145857642940577 1.456501983874542 0.1452539015982679 1.0 0.1506678059401541 2 O15382 1 +Branched-chain amino acid aminotransferase II [IPR005786] 0.5145857642940577 1.456501983874542 0.1452539015982679 1.0 0.1506678059401541 2 O15382 1 +Aminotransferase class IV [IPR001544] 0.5145857642940577 1.456501983874542 0.1452539015982679 1.0 0.1506678059401541 2 O15382 1 +Casein Kinase 2, subunit alpha [IPR045216] 0.5137106184364145 1.451438761272561 0.1466577229759158 1.0 0.1520636556896535 2 P68400 1 +Mrp/NBP35 ATP-binding protein [IPR019591] 0.5090431738623198 1.4244116252149557 0.1543273509458034 1.0 0.1598892475541472 2 Q9Y5Y2 1 +Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756] 0.5090431738623198 1.4244116252149557 0.1543273509458034 1.0 0.1598892475541472 2 Q9Y5Y2 1 +NADH:cytochrome b5 reductase-like [IPR001834] 0.5020420070011735 1.383802473121105 0.1664189455821976 1.0 0.1720758741672051 2 Q9UHQ9 1 +Glutathione Transferase family [IPR040079] 0.5727341437549841 1.3312050665969966 0.1831215447496288 1.0 0.1892714188324887 11 Q8TB36,Q13505,Q9H7Z7,O15217 4 +Proteasome, subunit alpha/beta [IPR001353] 0.5342954668153985 1.3148124078082282 0.1885729563751605 1.0 0.1946751593833544 14 P28072,P49721,P60900 3 +Ribose-phosphate pyrophosphokinase [IPR005946] 0.5185293259410709 1.3107641796016465 0.1899374479612141 1.0 0.196006455174176 3 Q14558,P11908 2 +Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661] 0.4862893815635987 1.2921855496080588 0.1962928947627169 1.0 0.2022458498224763 2 O43683 1 +Developmentally regulated GTP-binding protein [IPR045001] 0.4600350058343181 1.1390928764838466 0.2546644183393949 1.0 0.2614607999905247 2 P55039 1 +Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554] 0.4577012835472628 1.125484062425404 0.2603839670773586 1.0 0.2672281121515772 2 Q16537 1 +Prefoldin alpha-like [IPR004127] 0.4797619696347087 1.0956431361580337 0.2732349765470174 1.0 0.2801970594460986 3 Q9UBK9 1 +DNA ligase, ATP-dependent [IPR000977] 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.3167600224531275 2 P18858 1 +Ubiquitin conjugation factor E4 [IPR045132] 0.4361143523920681 0.9998538868344988 0.3173812232457971 1.0 0.3248314867022712 2 O95155 1 +Oxysterol-binding protein [IPR000648] 0.520148057215944 0.942400926067132 0.3459874132910716 1.0 0.3532798880442792 6 Q9BXW6 1 +TAF15/EWS/TLS family [IPR034870] 0.4490808287131705 0.9260981780470268 0.3543949607542005 1.0 0.3617234558458793 3 P35637,Q01844 2 +DNA-directed RNA polymerase, subunit 2 [IPR015712] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.3715746200451373 3 P30876,Q9H9Y6 2 +HnRNP R/Q splicing factor [IPR006535] 0.4414940180916351 0.8844967191828893 0.3764281327119394 1.0 0.3834641725757139 3 A0AV96,O60506 2 +Malic oxidoreductase [IPR001891] 0.4095682613768947 0.8467981158822036 0.3971076586108999 1.0 0.4043727656388144 2 P48163 1 +Mesoderm induction early response protein/metastasis-associated protein [IPR040138] 0.4049008168028182 0.8201656424355405 0.4121216853514344 1.0 0.4194981824433278 2 O94776 1 +Beta tubulin [IPR002453] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.4650481158659855 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Tubulin [IPR000217] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.4650481158659855 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.4151056784170386 0.7245020423016516 0.4687575738011746 1.0 0.4764062987816134 17 Q53GQ0,Q3SXM5,Q06136 3 +Cullin [IPR045093] 0.4742990654205711 0.7193386235753862 0.4719323036312643 1.0 0.4792604449919982 6 Q13617,Q93034,Q13616,Q13618,Q13620 5 +Small GTPase superfamily, ARF/SAR type [IPR006689] 0.4499019623703153 0.7170158051417387 0.4733643444507058 1.0 0.4805281820267933 12 Q9Y6B6,Q9NR31,Q9NXU5 3 +5'-3' exoribonuclease [IPR027073] 0.3847724620770192 0.7067380682351357 0.4797292677433531 1.0 0.4864231645025627 2 Q8IZH2 1 +Ribosomal protein S4/S9 [IPR022801] 0.3833138856476109 0.6986260758706119 0.4847857433375333 1.0 0.4913597460561748 2 P46781 1 +Structural maintenance of chromosomes protein [IPR024704] 0.4281961471103385 0.6831385918171188 0.4945192715403896 1.0 0.5006433492065245 4 Q14683,Q9NTJ3,O95347 3 +Threonine-tRNA ligase, class IIa [IPR002320] 0.3962649547709461 0.6420221561229151 0.5208587973176027 1.0 0.5269012427621224 3 A2RTX5,Q9BW92 2 +Ribosomal RNA adenine dimethylase [IPR011530] 0.3710618436406163 0.6311910135065578 0.5279156371009734 1.0 0.5338335162953795 2 Q9UNQ2 1 +Ribosomal protein L1/ribosomal biogenesis protein [IPR028364] 0.3880945433323735 0.5997163941640186 0.5486952604638775 1.0 0.554631685229329 3 O76021,P62906 2 +Clathrin adaptor, mu subunit [IPR001392] 0.387802742923848 0.5982167321275711 0.5496953283552521 1.0 0.555427956345052 3 Q96CW1,Q9Y2T2 2 +Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309] 0.3605600933489025 0.5745432753334428 0.5656002249674976 1.0 0.570837264087567 2 P62241 1 +Alpha-D-phosphohexomutase superfamily [IPR005841] 0.3602683780630095 0.5729869135064493 0.5666535547029534 1.0 0.5716797914010513 2 Q96G03 1 +Myotubularin family [IPR030564] 0.3585180863477231 0.5636695414963923 0.5729790499227096 1.0 0.5773933723412205 2 Q9Y217 1 +Plakin [IPR043197] 0.4210218978102236 0.5572829102830434 0.5773341501071991 1.0 0.5815580041126042 5 Q9UPN3,P58107,Q15149,P15924 4 +Polyprenyl synthetase [IPR000092] 0.3793405310767622 0.5550943422056004 0.5788301324844896 1.0 0.5828405029174075 3 Q5T2R2,P14324 2 +Ribosomal protein L7, eukaryotic [IPR005998] 0.3561843640606821 0.5513030777844783 0.5814259289928714 1.0 0.5850039347097507 2 P18124 1 +Ribosomal protein L7/L30 [IPR039699] 0.3561843640606821 0.5513030777844783 0.5814259289928714 1.0 0.5850039347097507 2 P18124 1 +Ribosomal protein S5/S7 [IPR000235] 0.3506417736289404 0.5222051034985541 0.601527533043452 1.0 0.6049965499583508 2 P46782 1 +Sec1-like protein [IPR001619] 0.385985401459859 0.3990917265101031 0.6898256182365425 1.0 0.6924726850755162 5 Q96AX1,O00186,Q9H267,Q9NRW7 4 +Phosphatidylinositol kinase [IPR015433] 0.3211785297549526 0.3751986212471572 0.7075127555115617 1.0 0.7099552621473899 2 O00443 1 +HnRNP-L/PTB [IPR006536] 0.3101479155630491 0.1698898462796632 0.8650967665356042 1.0 0.8660795514287677 4 Q9UKA9 1 +Small GTPase [IPR001806] 0.2908128106736944 0.1694821504998042 0.8654174110989292 1.0 0.8660795514287677 31 P62820,P61020,Q15382,Q969Q5,Q15907,P61019,P20337 7 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b751a354dee02c663c845e6a83eccdca74b7000b --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1,4-alpha-glucan-branching enzyme [IPR037439]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [IPR028381]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S17, mitochondrial [IPR039193]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S26 [IPR026140]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-keto-steroid reductase [IPR042829]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "3-oxoacid CoA-transferase [IPR014388]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "4-aminobutyrate aminotransferase, eukaryotic [IPR004631]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease 1 [IPR016494]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5'-deoxynucleotidase YfbR/HDDC2 [IPR039356]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "50S ribosomal protein uL4 [IPR013005]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 13 [IPR028852]", "A-kinase anchor protein 9/Pericentrin [IPR028745]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ABI family [IPR028457]", "ABT1/Esf2 [IPR039119]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor 6 [IPR041838]", "ADP-ribosylation factor-like protein 10 [IPR042951]", "ADP-ribosylation factor-like protein 15 [IPR042292]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "ALG11 mannosyltransferase [IPR038013]", "AMP deaminase 2 [IPR029749]", "AMP deaminase [IPR006329]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-binding cassette subfamily B member 10-like [IPR030260]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Abl interactor 1 [IPR028456]", "Abr/Bcr [IPR037769]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-histidine N-methyltransferase SETD3 [IPR025785]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-coenzyme A diphosphatase NUDT19 [IPR039121]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein Cbl [IPR024162]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase 4, mitochondrial [IPR028585]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "Adenylyltransferase and sulfurtransferase MOCS3/Uba4 [IPR028885]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase [IPR011408]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Alpha/gamma-adaptin-binding protein p34 [IPR019341]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase ALAT1/2-like [IPR045088]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid beta precursor protein binding family B member 1/2/3 [IPR039576]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 4 [IPR024789]", "Anaphase-promoting complex subunit 4, metazoa [IPR017169]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Ankyrin repeat and SAM domain-containing protein 1A [IPR033637]", "Ankyrin repeat domain-containing protein 13 [IPR021832]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A3 [IPR002390]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 1 [IPR013306]", "Antigen peptide transporter 2 [IPR005293]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator BAX [IPR026304]", "Apoptosis regulator, Mcl-1 [IPR013281]", "ArfGAP ACAP1/2/3-like [IPR045258]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Arginine-tRNA-protein transferase 1, eukaryotic [IPR017137]", "Armadillo repeat protein deleted in velo-cardio-facial syndrome [IPR028444]", "Armadillo repeat-containing protein 6 [IPR040104]", "Armadillo-type fold containing protein ARMC8/Vid28 [IPR038739]", "Arrestin [IPR000698]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arsenite methyltransferase-like [IPR026669]", "Arylesterase [IPR002640]", "Ashwin [IPR024887]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atg6/Beclin [IPR007243]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase B [IPR028772]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 9 [IPR007241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BAG family molecular chaperone regulator 2 [IPR037689]", "BBP/SF1 family [IPR031150]", "BCAS3-like [IPR045142]", "BCP1 family [IPR025602]", "BEN domain-containing protein 3 [IPR033583]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRCA1-associated [IPR031099]", "BRI3-binding protein [IPR033367]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "BRO1 domain-containing protein BROX [IPR038898]", "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1/2/3 [IPR045068]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beclin-1 [IPR032913]", "Beta tubulin [IPR002453]", "Beta-1,4-galactosyltransferase [IPR003859]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-2-syntrophin [IPR028550]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-adducin [IPR027773]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-ketoacyl synthase [IPR000794]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional polynucleotide phosphatase/kinase PNKP [IPR006550]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biogenesis of lysosome-related organelles complex 1 subunit 1 [IPR009395]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bromodomain-containing protein 8 [IPR038002]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 2-like [IPR039934]", "C2 domain-containing protein 5 [IPR038983]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT complex, subunit 3/ 5 [IPR012270]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 10 [IPR039740]", "CCR4-NOT transcription complex subunit 11 [IPR019312]", "CCR4-NOT transcription complex subunit 4 [IPR039780]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDCA7/CDA7L [IPR040221]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CEBPZ/Mak21-like [IPR040155]", "CGI121/TPRKB [IPR013926]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 2 [IPR037354]", "COMM domain-containing protein 7 [IPR037358]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome complex subunit 7B [IPR027530]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF6/7 family [IPR034772]", "CTD phosphatase Fcp1 [IPR039189]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain small subunit 1 [IPR029642]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calsyntenin [IPR026914]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carboxymethylenebutenolidase homolog [IPR042946]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Caspase-3/7 [IPR015471]", "Cat eye syndrome critical region protein 2 [IPR029614]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle checkpoint, Hus1 [IPR016580]", "Cell division cycle-associated 7-like protein [IPR033578]", "Cell division cycle-associated protein 2 [IPR033064]", "Cell division protein Cdc6/18 [IPR016314]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centromere protein Cenp-F [IPR043513]", "Centromere protein U [IPR025214]", "Centrosomal protein of 170kDa [IPR026644]", "Centrosomal protein of 290kDa [IPR026201]", "Centrosomal protein of 44kDa [IPR033603]", "Centrosomal protein of 55kDa [IPR038926]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Checkpoint protein Hus1/Mec3 [IPR007150]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel CLIC-like [IPR009231]", "Chloride channel ClC-7 [IPR002249]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin complexes subunit BAP18 [IPR037931]", "Chromatin modification-related protein Eaf7/MRGBP [IPR012423]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromodomain-helicase-DNA-binding protein 8 [IPR034724]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Chromosome transmission fidelity protein 8 [IPR018607]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cilia- and flagella-associated protein 298 [IPR021298]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Citron Rho-interacting kinase [IPR017405]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Coenzyme A transferase family I [IPR004165]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil and C2 domain-containing protein 1 [IPR039725]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 127 [IPR034607]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 93 [IPR039116]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Condensin-2 complex subunit D3 [IPR012371]", "Condensin-2 complex subunit G2 [IPR024741]", "Conserved oligomeric Golgi complex subunit 5 [IPR019465]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Conserved oligomeric Golgi complex subunit 8 [IPR007255]", "Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae [IPR016632]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Copper homeostasis protein CutC [IPR005627]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Core-binding factor, beta subunit [IPR003417]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin 7 [IPR027331]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Csn12 family [IPR045114]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine oxygenase/2-aminoethanethiol dioxygenase [IPR012864]", "Cysteine protease ATG4B, metazoa [IPR032916]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit VIb [IPR003213]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoplasmic dynein 2 heavy chain 1 [IPR026815]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDB1- and CUL4-associated factor 15 [IPR038914]", "DDB1- and CUL4-associated factor 16 [IPR028216]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DET1- and DDB1-associated protein 1 [IPR033575]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase delta/II small subunit family [IPR024826]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair protein XRCC4 [IPR010585]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-binding protein SATB1/SATB2 [IPR039673]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase III subunit Rpc5 [IPR006886]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Daxx protein [IPR005012]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "DeoC/FbaB/LacD aldolase [IPR002915]", "Deoxycytidylate deaminase [IPR016473]", "Deoxycytidylate deaminase-related [IPR015517]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyribose-phosphate aldolase [IPR011343]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Diacylglycerol kinase [IPR037607]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydropyrimidinase-related protein 3 [IPR030628]", "Dihydropyrimidinase-related protein 5 [IPR030626]", "Dihydroxyacetone kinase [IPR012734]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dim1 family [IPR004123]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphosphomevalonate decarboxylase [IPR029765]", "Diphosphomevalonate/phosphomevalonate decarboxylase [IPR005935]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Diphthine synthase [IPR004551]", "Divalent ion tolerance protein, CutA [IPR004323]", "Divergent protein kinase domain 2A/B [IPR020519]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dual specificity protein phosphatase 12 [IPR016278]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein heavy chain [IPR026983]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase HECTD3 [IPR042469]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase RNF213 [IPR031248]", "E3 ubiquitin-protein ligase UBR1-like [IPR039164]", "E3 ubiquitin-protein ligase UBR7 [IPR040204]", "E3 ubiquitin-protein ligase ZNF598/Hel2 [IPR044288]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EF-hand calcium-binding domain-containing protein 14 [IPR042352]", "EF-hand domain-containing protein D1/2 [IPR040365]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 3 [IPR008568]", "ER membrane protein complex subunit 7 [IPR039163]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "ESCRT-II complex, Vps25 subunit [IPR008570]", "ETS family [IPR046328]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelin-converting enzyme 1 [IPR029734]", "Engulfment and cell motility protein 2 [IPR030713]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ependymin [IPR001299]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Erbin [IPR032927]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Est1/Ebs1-like [IPR045153]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Eukaryotic-type methylenetetrahydrofolate reductase [IPR004621]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Exo84 [IPR033961]", "Exocyst complex component Sec10-like [IPR009976]", "Exocyst complex component Sec8/EXOC4 [IPR039682]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exostosin-like [IPR004263]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-6 [IPR040016]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Eyes absent family [IPR028472]", "Eyes absent homologue 4 [IPR028478]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM105 [IPR023235]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM20 [IPR024869]", "FAM91 [IPR039199]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FLYWCH-type zinc finger-containing protein 1/2 [IPR040312]", "FMP27 [IPR045167]", "FUN14 [IPR007014]", "FYVE and coiled-coil domain-containing protein 1 [IPR042654]", "Fanconi anaemia group A protein [IPR003516]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Far11/STRP [IPR040185]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 2 [IPR030305]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "FeS cluster insertion protein [IPR016092]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Focadhesin [IPR021392]", "Focadhesin/RST1 [IPR045163]", "Folliculin [IPR021713]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "G2 and S phase-expressed protein 1 [IPR026659]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GDP-mannose 4,6-dehydratase [IPR006368]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf1 [IPR005339]", "GINS complex, subunit Psf3 [IPR010492]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI transamidase subunit PIG-U [IPR009600]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP cyclohydrolase 1 type 2/Nif3 [IPR002678]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "GTP-binding protein Rheb [IPR037586]", "GTP-binding protein, ribosome biogenesis, YsxC [IPR019987]", "GTPase HflX [IPR016496]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gem-associated protein 4 [IPR033265]", "Gemin6 [IPR009422]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glomulin/ALF4 [IPR019516]", "Glucosamine 6-phosphate N-acetyltransferase [IPR039143]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose transporter GLUT [IPR045263]", "Glucose transporter, type 1 (GLUT1) [IPR002439]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-cysteine ligase catalytic subunit [IPR004308]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, alpha class [IPR003080]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glutathione-specific gamma-glutamylcyclotransferase [IPR006840]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 47 [IPR001382]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycosyltransferase 61 [IPR007657]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi phosphoprotein 3-like [IPR008628]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanidinoacetate N-methyltransferase [IPR016550]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor Ect2 [IPR026817]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-binding protein, beta subunit [IPR016346]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex non-core subunit Naf1 [IPR040309]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like [IPR011949]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 3 [IPR026206]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS augmin-like complex subunit 6 [IPR026797]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HCLS1-binding protein 3 [IPR039701]", "HMG-CoA lyase [IPR043594]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 12A [IPR026685]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Hermansky-Pudlak syndrome 5 protein [IPR035431]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histidine-tRNA ligase [IPR015807]", "Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit [IPR004516]", "Histone H2A [IPR002119]", "Histone H3/CENP-A [IPR000164]", "Histone H4 [IPR001951]", "Histone PARylation factor 1 [IPR019361]", "Histone acetyltransferase Rtt109/CBP [IPR013178]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase SETD1A [IPR037841]", "Histone-lysine N-methyltransferase SETD2, animal [IPR042294]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Set1-like [IPR044570]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "Histone-lysine N-methyltransferase, SET [IPR017155]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Huntingtin-interacting protein 1 [IPR030554]", "Huntingtin-interacting protein 1-related protein [IPR030555]", "Hyccin [IPR018619]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxyacylglutathione hydrolase [IPR017782]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inactive ubiquitin thioesterase OTULINL [IPR023236]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol 3,4-bisphosphate 4-phosphatase [IPR039034]", "Inositol monophosphatase-like [IPR000760]", "Inositol-tetrakisphosphate 1-kinase [IPR008656]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 12 [IPR039053]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 7 [IPR033060]", "Integrator complex subunit 8 [IPR038751]", "Integrator complex subunit 9 [IPR027074]", "Integrin alpha chain [IPR000413]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interferon-stimulated 20kDa exonuclease-like 2 [IPR034933]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Interleukin-1 receptor-associated kinase 1 [IPR035536]", "Intermembrane space protein MIX23 [IPR019171]", "Intersectin-2 [IPR027029]", "Intracellular chloride channel [IPR002946]", "Intracellular hyaluronic acid binding protein [IPR026203]", "Intracellular lipid binding protein [IPR031259]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intraflagellar transport protein 52 homolog [IPR039975]", "Intron Large complex component GCFC2-like [IPR012890]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Iron-sulfur protein NUBPL-like [IPR044304]", "Isoamyl acetate-hydrolyzing esterase Iah1-like [IPR045136]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "JmjC domain-containing [IPR039994]", "Junction plakoglobin [IPR030461]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Katanin p80 WD40 repeat-containing subunit B1 [IPR026962]", "Keratin, type I [IPR002957]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Ndc80 [IPR005550]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Kintoun [IPR034727]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LAR-interacting protein, Liprin [IPR029515]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Learning associated protein 18-like [IPR018784]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat flightless-interacting protein 1/2 [IPR019139]", "Leucine-rich repeat-containing 41 [IPR026137]", "Leucine-rich repeat-containing protein 14 [IPR026292]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte elastase inhibitor (serpin B1) [IPR015557]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "LicD family [IPR007074]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Liprin-alpha-1 [IPR030438]", "Liprin-beta-1 [IPR030437]", "LisH domain-containing protein ARMC9 [IPR040369]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lunapark family [IPR040115]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "M-phase inducer phosphatase [IPR000751]", "M-phase phosphoprotein 6 [IPR019324]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICAL-like protein [IPR028563]", "MICAL3 [IPR029941]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MICRORCHIDIA ATPase family [IPR045261]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Magnesium transporter protein 1 [IPR006844]", "Major centromere autoantigen B [IPR033062]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mannosyltransferase ALG2 [IPR027054]", "Mediator complex, subunit Med14 [IPR013947]", "Mediator complex, subunit Med16 [IPR021665]", "Mediator complex, subunit Med17 [IPR019313]", "Mediator complex, subunit Med21 [IPR021384]", "Mediator complex, subunit Med23 [IPR021629]", "Mediator complex, subunit Med24, [IPR021429]", "Mediator complex, subunit Med4 [IPR019258]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D1 [IPR030083]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionine-tRNA synthetase, type 2 [IPR023457]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylenetetrahydrofolate reductase-like [IPR003171]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylmalonic aciduria and homocystinuria type C family [IPR032037]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthioribulose-1-phosphate dehydratase [IPR017714]", "Methylthioribulose-1-phosphate dehydratase, eukaryotes [IPR027514]", "Methylthiotransferase [IPR005839]", "Methyltransferase Ppm1/Ppm2/Tcmp [IPR007213]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microfibrillar-associated protein 1 [IPR033194]", "Microspherule protein 1 [IPR037912]", "Microtubule associated protein 1 [IPR026074]", "Microtubule associated protein 1A [IPR015656]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial dynamics protein MID49/MID51 [IPR045909]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit TIM22 [IPR039175]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial transcription factor TFB2 [IPR016861]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitogen-activated protein (MAP) kinase kinase kinase 7 [IPR017421]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitoguardin [IPR019392]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdenum cofactor biosynthesis C [IPR023045]", "Molybdenum cofactor biosynthesis protein A [IPR013483]", "Molybdopterin biosynthesis MoaE [IPR003448]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Molybdopterin synthase catalytic subunit, eukaryotes [IPR028888]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple PDZ domain protein [IPR032078]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-acyl-L-amino-acid amidohydrolase [IPR010159]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-end rule aminoacyl transferase [IPR030700]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-quinone oxidoreductase, chain I [IPR010226]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H [IPR001694]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NF-kappa-B/Dorsal [IPR000451]", "NIF3-like protein 1, animal [IPR017222]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Nck-associated protein 1 [IPR019137]", "Nectin-2 [IPR033318]", "Negative cofactor 2 complex subunit beta [IPR042225]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neural cell adhesion [IPR009138]", "Neural cell adhesion molecule 1 [IPR033019]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neurogenic locus Notch 2 [IPR022336]", "Neuropilin [IPR014648]", "Neuropilin-1 [IPR027146]", "Niban-like [IPR026088]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Non-specific endonuclease [IPR040255]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Not2/Not3/Not5 [IPR040168]", "Notch [IPR008297]", "Nuclear MIS12/MIND complex subunit PMF1/Nnf1 [IPR007128]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 2 [IPR027157]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein DGCR14/ESS-2 [IPR019148]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear speckle splicing regulatory protein 1 [IPR042816]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase 7 [IPR011410]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC domain-containing protein 3 [IPR027761]", "NudC family [IPR037898]", "Nurim-like [IPR033580]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "Occludin [IPR002958]", "Octamer-binding transcription factor [IPR000972]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Opioid growth factor receptor [IPR039574]", "Origin recognition complex, subunit 3 [IPR020795]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PEX5/PEX5L [IPR024111]", "PH-interacting protein [IPR028738]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pat1-like [IPR039900]", "Patatin-like phospholipase domain-containing protein 4 [IPR033902]", "Patatin-like phospholipase domain-containing protein [IPR033562]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C14 family [IPR002398]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C50, separase [IPR005314]", "Peptidase C54 [IPR005078]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1A, Tysnd1 [IPR017345]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase E [IPR016304]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisomal targeting signal 1 receptor PEX5, animals [IPR024113]", "Peroxisomal/glyoxysomal leader peptide-processing protease [IPR039245]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin [IPR001200]", "Phosducin-like [IPR045037]", "Phosphatase Gpp1/Gpp2-like [IPR045228]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polynucleotide kinase 3 phosphatase [IPR013954]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 17 [IPR032847]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor 18 [IPR039979]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SLU7 [IPR039974]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable methyltransferase TARBP1 [IPR025806]", "Probable methyltransferase Trm3/TARBP1 [IPR045330]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Progesterone-induced-blocking factor 1 [IPR026205]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa [IPR002316]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Proline/serine-rich coiled-coil protein 1/G2 and S phase-expressed protein 1 [IPR026657]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Prostate apoptosis response 4 [IPR026117]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome inhibitor PI31-like [IPR045128]", "Proteasome maturation factor Ump1 [IPR008012]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CIP2A [IPR042510]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM8A1 [IPR039871]", "Protein Hgh1 [IPR039717]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LIN-9/Protein ALWAYS EARLY [IPR010561]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein Mon2-like [IPR026829]", "Protein NDRG1 [IPR030693]", "Protein NDRG3 [IPR030692]", "Protein OS-9-like [IPR045149]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SMG8 [IPR028802]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein Spindly, chordates [IPR028593]", "Protein TFG [IPR033512]", "Protein XRP2 [IPR039093]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein diaphanous homologue 2 [IPR027644]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein furry/Tao3/Mor2 [IPR039867]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein jagunal [IPR009787]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C, alpha/beta/gamma types [IPR014375]", "Protein kinase C, delta [IPR027436]", "Protein kinase C, delta/epsilon/eta/theta types [IPR014376]", "Protein kinase Mps1 family [IPR027084]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF4726 [IPR031714]", "Protein of unknown function DUF719 [IPR007998]", "Protein of unknown function DUF842, eukaryotic [IPR008560]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase 4 core regulatory subunit R2 [IPR015267]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein spinster-like [IPR044770]", "Protein strawberry notch [IPR026741]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein unc-119 homologue A-like [IPR032977]", "Protein virilizer [IPR026736]", "Protein wntless [IPR009551]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Proto-oncogene c-Rel [IPR030505]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA-binding protein 47 [IPR034442]", "Putative hydrolase RBBP9/YdeN [IPR010662]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate homeostasis protein [IPR011078]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxamine 5'-phosphate oxidase [IPR000659]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "RAB11-binding protein RELCH [IPR040362]", "RAD3/XPD family [IPR001945]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA methyltransferase Bin3-like [IPR039772]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II subunit A [IPR006811]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase II-associated protein RPAP1/Rba50 [IPR039913]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein 6 [IPR028806]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit Pop5/Rpp14/Rnp2-like [IPR002759]", "RNase P subunit p30 [IPR002738]", "ROK family [IPR000600]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab protein geranylgeranyltransferase component A [IPR001738]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab4 [IPR041819]", "Rabaptin [IPR003914]", "Rabaptin-5 [IPR029880]", "Rad21/Rec8-like protein [IPR039781]", "Ragulator complex protein LAMTOR2-like [IPR037587]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Ran-interacting Mog1 protein [IPR007681]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein [IPR039360]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab-23 [IPR034114]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Refilin family [IPR028215]", "Regulator of MON1-CCZ1 complex [IPR040371]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein 3 [IPR013970]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulophagy receptor 1/3 [IPR043384]", "Reticulophagy regulator 3 [IPR033361]", "Retinoblastoma protein family [IPR028309]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho GDP/GTP exchange factor Kalirin/TRIO [IPR028570]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2 subunit B [IPR040456]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein 7 [IPR040446]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal export protein Nmd3 [IPR039768]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, bacterial-type [IPR005823]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L16 [IPR000114]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L20 [IPR005813]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22, bacterial/chloroplast-type [IPR005727]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S16 [IPR000307]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S18 [IPR001648]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S27/S33, mitochondrial [IPR013219]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "Rieske iron-sulphur protein [IPR014349]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SAP30-binding protein [IPR012479]", "SCAMP [IPR007273]", "SCAR/WAVE family [IPR028288]", "SERRATE/Ars2 [IPR039727]", "SHC SH2 domain-binding protein 1-like [IPR045140]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SPIN90/Ldb17 [IPR030125]", "SPRY domain-containing protein 7 [IPR035766]", "SSNA1 family [IPR033362]", "STEEP-like [IPR029704]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1 [IPR027109]", "SWR1-complex protein 5/Craniofacial development protein 1/2 [IPR027124]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sarcolemmal membrane-associated protein [IPR030498]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sdc1/DPY30 [IPR037856]", "Sds3-like [IPR013907]", "Sec1-like protein [IPR001619]", "SecY/SEC61-alpha family [IPR002208]", "Selenium-binding protein [IPR008826]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase ATM/Tel1 [IPR015519]", "Serine/threonine-protein kinase Atg1-like [IPR045269]", "Serine/threonine-protein kinase MRCK beta [IPR033232]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase Rio1 [IPR017407]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase 4 regulatory subunit 1 [IPR031087]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit [IPR037981]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shikimate kinase/Threonine synthase-like 1 [IPR000623]", "Shikimate kinase/gluconokinase [IPR031322]", "Shootin-1 [IPR024849]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sialidase family [IPR026856]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sirtuin, class I [IPR017328]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sla2 family [IPR030224]", "Sm-like protein Lsm6/SmF [IPR016487]", "Sm-like protein Lsm7 [IPR017132]", "Sm-like protein Lsm7/SmG [IPR044641]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small kinetochore-associated protein [IPR033373]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smg8/Smg9 [IPR019354]", "Smooth muscle protein/calponin [IPR003096]", "Snapin [IPR017246]", "Snapin/Pallidin/Snn1 [IPR028119]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 12 member 9 [IPR030345]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-4 [IPR034783]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-8/Mvp1 [IPR028662]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Sperm-associated antigen 5 [IPR028728]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermatogenesis-defective protein 39 [IPR040057]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Spindle and kinetochore-associated protein 3 [IPR033341]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 3B subunit 5/RDS3 complex subunit 10 [IPR009846]", "Splicing factor 3B, subunit 5 [IPR017089]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterile alpha and TIR motif-containing protein 1 [IPR039184]", "Steroid receptor RNA activator 1 [IPR040243]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar/inositol transporter [IPR003663]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Syntaxin [IPR045242]", "Syntaxin-3 [IPR031186]", "Syntenin-1 [IPR030528]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "Syntrophin [IPR015482]", "T-complex 11 [IPR008862]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TATA-binding protein-associated factor Mot1 [IPR044972]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TFIIH subunit Tfb1/GTF2H1 [IPR027079]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TNF receptor-associated factor 2 [IPR027133]", "TNF receptor-associated factor TRAF [IPR043211]", "TNF receptor-associated factor TRAF, metazoa [IPR012227]", "TPMT family [IPR008854]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TRAPP III complex, Trs85 [IPR024420]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "Tapasin [IPR008056]", "Target of Myb protein 1 [IPR014645]", "Target of Myb1-like 2 [IPR027429]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Telomeric repeat-binding factor 1/2 [IPR017357]", "Telomeric repeat-binding factor 2 [IPR030657]", "Teneurin-3/4 [IPR027691]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "Tetratricopeptide repeat protein TTC27/Emw1 [IPR044244]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thiopurine S-methyltransferase [IPR025835]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine synthase-like [IPR004450]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Timeless [IPR044998]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A [IPR030549]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit 13 [IPR010378]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation factor, mitochondrial [IPR039150]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor RelA (p65) [IPR030495]", "Transcription factor STAT [IPR001217]", "Transcription factor Spt20 [IPR021950]", "Transcription factor TFIIB [IPR000812]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription factor, enhancer of yellow 2 [IPR018783]", "Transcription initiation factor IIF, alpha subunit [IPR008851]", "Transcription initiation factor IIF, beta subunit [IPR003196]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription initiation factor TFIIE, beta subunit [IPR016656]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription termination factor, mitochondrial/chloroplastic [IPR003690]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transforming growth factor-beta-related [IPR015615]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation initiation factor aIF-2, bacterial-like [IPR000178]", "Translation machinery-associated protein 16 [IPR021346]", "Translation release factor pelota [IPR004405]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Translocon-associated protein subunit gamma [IPR009779]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 160 [IPR026801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Trimethyllysine dioxygenase [IPR012776]", "Trinucleotide repeat-containing gene 6A protein [IPR033501]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-1 [IPR030135]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "TspO/MBR-related protein [IPR004307]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Twinkle-like protein [IPR027032]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "Tyrosine/threonine-protein kinase, Cdc2 inhibitor [IPR016235]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U4/U6.U5 small nuclear ribonucleoprotein component Snu23 [IPR040107]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing [IPR020004]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 4-epimerase [IPR005886]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "UPF0600 protein C5orf51 [IPR037657]", "UPF0767 family [IPR031933]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquinol-cytochrome c chaperone, CBP3 [IPR007129]", "Ubiquinol-cytochrome c chaperone/UPF0174 [IPR021150]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin thioesterase otulin [IPR023237]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-like modifier-activating enzyme Atg7 [IPR006285]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3A [IPR017134]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Ubiquitously expressed transcript protein UXT [IPR003994]", "Uncharacterised conserved protein UCP013899, metal binding [IPR016617]", "Uncharacterised protein family UPF0449 [IPR028227]", "Unconventional myosin-XVIIIa [IPR031244]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Ureohydrolase [IPR006035]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated Vps28 [IPR007143]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vam6/VPS39/TRAP1 family [IPR032914]", "Vang-like protein [IPR009539]", "Vasodilator-stimulated phosphoprotein [IPR034367]", "Vasodilator-stimulated phosphoprotein/ENA/VASP-like [IPR017354]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Vezatin [IPR026858]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Vma22/CCDC115 [IPR040357]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "Vps72/YL1 family [IPR008895]", "WASH complex subunit 3 [IPR019309]", "WASH complex subunit 7 [IPR027307]", "WASH complex, subunit strumpellin [IPR019393]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat and coiled-coil-containing protein family [IPR028041]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat protein 35 [IPR017233]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 47 [IPR040067]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WDR48/Bun107 [IPR021772]", "WDR74/Nsa1 [IPR037379]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XAP5 protein [IPR007005]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "Yippee family [IPR039058]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 [IPR044598]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 622/Rei1/Reh1 [IPR040025]", "Zinc finger protein 638 [IPR033096]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "mRNA-decapping enzyme subunit 1 [IPR010334]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 [IPR014816]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase, Trm7 [IPR028590]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG [IPR004416]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related [IPR002218]", "tRNA-guanine transglycosylase [IPR004803]", "tRNA-specific 2-thiouridylase [IPR004506]"], "available_proteins": ["AAAS", "AAGAB", "AAR2", "AARS", "AARS2", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACADM", "ACAP2", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADO", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKT1S1", "ALDH16A1", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANKLE2", "ANKRD13A", "ANKS1A", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEX1", "API5", "APIP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFIP1", "ARG2", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL15", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARL8B", "ARMC1", "ARMC6", "ARMC8", "ARMC9", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARVCF", "AS3MT", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAIAP2", "BANF1", "BAP18", "BAX", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT1", "BCAT2", "BCCIP", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BDH2", "BECN1", "BEND3", "BICD2", "BIRC6", "BLM", "BLMH", "BLOC1S1", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD8", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUD23", "BUD31", "BYSL", "C12orf73", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C21orf59", "C2CD2L", "C2CD5", "C2orf49", "C3orf58", "C5orf51", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CBR1", "CBX3", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD3EAP", "CDC25C", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK5RAP3", "CDKAL1", "CEBPZ", "CECR2", "CELF2", "CENPB", "CENPF", "CENPU", "CEP170", "CEP290", "CEP44", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHD8", "CHERP", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHTF8", "CIAPIN1", "CIP2A", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT4", "CNOT7", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG5", "COG7", "COG8", "COIL", "COLGALT1", "COMMD2", "COMMD7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRNKL1", "CROT", "CRTAP", "CS", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWF19L1", "CXorf56", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DCAF1", "DCAF15", "DCAF16", "DCAF7", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDA1", "DDB1", "DDOST", "DDRGK1", "DDT", "DDX54", "DEK", "DENR", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX29", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPH1", "DPH2", "DPH5", "DPM1", "DPP3", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EFCAB14", "EFHD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "ENDOD1", "ENDOG", "ENO1", "ENO2", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ESD", "ESF1", "ESPL1", "ESS2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAH", "FAM105A", "FAM114A2", "FAM120A", "FAM120B", "FAM126A", "FAM129B", "FAM136A", "FAM162A", "FAM20B", "FAM213A", "FAM49B", "FAM50A", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FLYWCH1", "FMR1", "FN3KRP", "FNTB", "FOCAD", "FOXC1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALE", "GALK1", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GCAT", "GCFC2", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN6", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GM2A", "GMDS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNE", "GNG5", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP6", "GTPBP8", "GTSE1", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDHD2", "HDHD3", "HDHD5", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELZ", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPF1", "HPRT1", "HPS5", "HS1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGBP1", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS12", "INTS14", "INTS3", "INTS7", "INTS8", "INTS9", "IPO4", "IPO5", "IRAK1", "IRGQ", "IRS4", "ISCA2", "ISG20L2", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KATNB1", "KCTD10", "KDELR1", "KDELR3", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1468", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN1", "LMF2", "LNPEP", "LNPK", "LONP1", "LRPAP1", "LRPPRC", "LRRC14", "LRRC41", "LRRC47", "LRRFIP1", "LSM12", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LZTFL1", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAK16", "MAN1A2", "MAP1A", "MAP1B", "MAP1S", "MAP3K7", "MAP4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARCKS", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCRS1", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "MFAP1", "MFN1", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOCS2", "MOCS3", "MOGS", "MON2", "MORC3", "MORF4L1", "MOV10", "MPC2", "MPDZ", "MPHOSPH10", "MPHOSPH6", "MPI", "MPST", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL4", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL50", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTR", "MTX1", "MTX2", "MVD", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "MYO18A", "NAA15", "NAA25", "NAA35", "NAA40", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCLN", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG1", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF3", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NELFB", "NELFCD", "NELFE", "NES", "NEU1", "NF1", "NHP2", "NIF3L1", "NIP7", "NIPBL", "NLN", "NMD3", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRM", "NRP1", "NSA2", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT19", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARS2", "PATL1", "PAWR", "PAXBP1", "PBDC1", "PBRM1", "PC", "PCBD1", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCNT", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDCL", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEBP1", "PELO", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PKM", "PKMYT1", "PKP2", "PLA2G15", "PLBD2", "PLCG1", "PLCG2", "PLEC", "PLIN3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA4", "PNPO", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLD2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "POMP", "PON2", "POP1", "POR", "POU2F1", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPFIBP1", "PPIE", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CC", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP5C", "PPP6R3", "PPT1", "PPWD1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSMG3", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTRH2", "PUDP", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP5", "RBBP6", "RBBP9", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REL", "RELA", "REPS1", "RER1", "RETREG3", "REXO2", "REXO4", "RFC1", "RFLNB", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOK1", "RIOX2", "RMC1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTFDC1", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARS", "SARS2", "SART1", "SATB2", "SBDS", "SBNO1", "SCAF1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SF3B5", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLFN11", "SLK", "SLMAP", "SLTM", "SLU7", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMCHD1", "SMG5", "SMG8", "SMIM12", "SMPD4", "SMS", "SMU1", "SMYD3", "SNAPIN", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG5", "SPAG9", "SPART", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPNS1", "SPR", "SPRYD7", "SPTBN1", "SPTBN2", "SQLE", "SRA1", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF6", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR3", "SSR4", "SSRP1", "SSU72", "STAG1", "STAG2", "STARD3", "STAT1", "STAT3", "STIP1", "STMN1", "STOML2", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX12", "STX3", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SURF4", "SURF6", "SYMPK", "SYNCRIP", "SYNE2", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TAPBP", "TARBP1", "TARS", "TARS2", "TARSL2", "TBCA", "TBCD", "TBCE", "TBL2", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TCP11L1", "TECR", "TEFM", "TENM3", "TERF2", "TERF2IP", "TES", "TEX10", "TFB1M", "TFB2M", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THNSL1", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKFC", "TM7SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM160", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM33", "TMEM43", "TMEM87A", "TMEM97", "TMLHE", "TMOD1", "TMOD3", 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sha256:c42fcb5fbdcb9c4ece97ee9e563ad61b5f6e16237f55bb30c47a705c606ce609 +size 130971 diff --git a/interpro_homologous_superfamily/basic/plot_9.png b/interpro_homologous_superfamily/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..1808772748b2012a5c74435f5a4d4000a605fdb5 --- /dev/null +++ b/interpro_homologous_superfamily/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3fc736f7833bf134c6b82d84fadbaf99bc426bfb01a78e357101c00b153c685f +size 134690 diff --git a/interpro_homologous_superfamily/consensus.joblib b/interpro_homologous_superfamily/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..c32849bfaab77b580034cdcdb40316863d1d3131 --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bf502d05e844fda5fe46a9d44fab617108452d44655dedf6524698591318d057 +size 353162 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d6af621331f35b3376dd3c72e6eab34183ba4a84 --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,13 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier domain superfamily [IPR023395] 12 20 3.134812262604202 0.0017196412523967 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.2674108336121077 1.0 0.0513963234576887 2.19272845709178e-07 1.3245802425307256e-08 +P-type ATPase, A domain superfamily [IPR008250] 2 5 2.536446892878383 0.0111983726465285 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.0 1.0 1.0 0.4172977923286156 0.0892170338783466 +P-type ATPase, transmembrane domain superfamily [IPR023298] 2 5 2.536446892878383 0.0111983726465285 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.0 1.0 1.0 0.4314443861210575 0.09905667817091 +P-type ATPase, cytoplasmic domain N [IPR023299] 2 5 2.536446892878383 0.0111983726465285 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.0 1.0 1.0 0.4172977923286156 0.0892170338783466 +GOLD domain superfamily [IPR036598] 2 5 2.52432420210232 0.0115920967688849 1.6893203883495145 3.9635922330097086 0.2675315261133384 0.342496534532029 0.9581447102086512 0.7543625282431146 1.3547328505855056 0.3000927322795711 1.0 1.0 1.0 0.0231366382468947 0.010684483318579 +Glycoside hydrolase superfamily [IPR017853] 6 16 2.5211038609406087 0.0116987316322343 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 0.0187491014912179 0.1201219647894398 0.0255840399150975 0.0033024410276518 0.0001833997890783 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 5 7 2.477641840750612 0.0132253829642006 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0040983965897468 0.0573151884822011 0.0056684159955205 0.000142755965642 9.354890231096924e-06 +EF-hand domain pair [IPR011992] 15 57 2.44203579337103 0.0146046985338625 13.3252427184466 49.37378640776699 0.9065364020670126 0.4404331516970506 4.9772339658485505 4.730718887980642 1.169914018421813 0.3730081256676846 0.0847137862779167 0.1283414687065841 0.0074800485008838 0.0036796440617279 0.0004345875602331 +Histidine phosphatase superfamily [IPR029033] 1 6 2.245122962138685 0.0247602398930639 1.1262135922330097 5.514563106796117 0.7684120115144248 0.3501978831807532 1.087703661549979 0.6771453167512235 0.986671075305162 0.2738673806375665 0.1298272630870375 0.0802348466038066 0.1515272625734178 0.062605312422627 0.1998160014011807 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 2 6 2.229795062353406 0.0257610513544361 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 1.0 1.0 1.0 0.0188064524051028 0.0077568745967145 +Peptidase M4/M1, CTD superfamily [IPR027268] 2 6 2.229795062353406 0.0257610513544361 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 1.0 1.0 1.0 0.0188064524051028 0.0077568745967145 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 5 8 2.1190594496623096 0.0340854431078403 2.3689320388349513 6.349514563106796 0.6640264147492347 0.3307390797434538 1.7803691733569 2.1393617497725477 1.1694677427725269 0.279101120079799 0.1154630790463651 1.0 0.1349531130589082 0.0051503840765812 0.0005388274165263 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3b831a6ce8edcdf097cb3e241a26b501b26c956e --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 1008, + "title": "Average number of proteins per term", + "value": 5.122023809523809 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d441e9548dc0d99e794dcd168d2039716f7ec8cc --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..deef3171d2331e1803429fa50357f970196cd783 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,147 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Haem oxygenase-like, multi-helical [IPR016084] 0.9953325554259038 3.893479058401399 9.881673655409706e-05 0.0948116109084763 0.0017195474405023 2 P30519 1 +Tetraspanin, EC2 domain superfamily [IPR008952] 0.9854142357059504 3.8498930701706993 0.0001181694027019 0.112300324392213 0.0017195474405023 2 O60637 1 +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.963827304550755 3.754205102944503 0.0001738924352541 0.1607937855725469 0.0020728238410698 2 A6NIH7 1 +Cytochrome P450 superfamily [IPR036396] 0.95828471411902 3.7294513704841266 0.0001918971353229 0.1758896798306023 0.0020819245267955 2 Q6UW02 1 +FAD-binding, type PCMH-like superfamily [IPR036318] 0.9404900816802738 3.649457366574109 0.0002627948485121 0.2327418937521425 0.0022448915872898 2 Q15392 1 +FAD-binding, type PCMH, subdomain 2 [IPR016169] 0.9404900816802738 3.649457366574109 0.0002627948485121 0.2327418937521425 0.0022448915872898 2 Q15392 1 +Ribosomal protein L23/L15e core domain superfamily [IPR012678] 0.9077475291961188 3.2767799158209163 0.0010499817823059 0.6531759425011836 0.0049771871031953 3 P62847 1 +WGR domain superfamily [IPR036930] 0.838973162193687 3.1770448007374936 0.0014878405038238 0.777061654894256 0.0063818860759765 2 Q9UGN5 1 +Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616] 0.838973162193687 3.1770448007374936 0.0014878405038238 0.777061654894256 0.0063818860759765 2 Q9UGN5 1 +Mitochondrial carrier domain superfamily [IPR023395] 0.7833267581492319 3.134812262604202 0.0017196412523967 0.8235804837081725 0.0070238805995397 20 Q70HW3,Q9BSK2,Q9Y6C9,Q9Y619,Q9UBX3,O43808,Q9NZJ7,Q9BQT8,O43772,P12236,P12235,Q9H2D1 12 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.8760800490561897 3.1327297686513624 0.0017318881337633 0.8257486884462517 0.0070392872533607 3 P48449 1 +Alkaline-phosphatase-like, core domain superfamily [IPR017850] 0.80892648774796 3.031644698815487 0.0024322531246212 0.914110834241998 0.0087874951599219 2 P15289 1 +MAGE homology domain, winged helix WH1 motif [IPR041898] 0.8502767940972688 3.013393444647058 0.0025834374620552 0.926279512810274 0.0091372103921112 3 Q9Y5V3 1 +MAGE homology domain, winged helix WH2 motif [IPR041899] 0.8502767940972688 3.013393444647058 0.0025834374620552 0.926279512810274 0.0091372103921112 3 Q9Y5V3 1 +Translation initiation factor IF2/IF5, N-terminal [IPR016189] 0.8039673278879671 3.007388090008897 0.0026350312494796 0.9300249918789524 0.0092453932028311 2 P55010 1 +Translation initiation factor IF2/IF5, zinc-binding [IPR016190] 0.8039673278879671 3.007388090008897 0.0026350312494796 0.9300249918789524 0.0092453932028311 2 P55010 1 +Bcl-2-like superfamily [IPR036834] 0.8465129851181595 2.99583583841963 0.0027369373323713 0.9368735303536784 0.009480525192544 3 Q07812,Q9BXK5 2 +DCN1-like, PONY binding domain [IPR042460] 0.8395097753136636 2.963063590563443 0.0030459363642625 0.9538098795645212 0.0101094325631872 3 Q96GG9,Q92564 2 +Porin domain superfamily [IPR023614] 0.8751075879328145 2.920043308496958 0.0034998274484918 0.970812475411388 0.0112362914267446 4 P21796,P45880 2 +DNA polymerase family B, thumb domain [IPR042087] 0.8303532785666267 2.9200106751446 0.003500193956347 0.9708232943157692 0.0112362914267446 3 P28340 1 +DNA polymerase, palm domain superfamily [IPR023211] 0.8303532785666267 2.9200106751446 0.003500193956347 0.9708232943157692 0.0112362914267446 3 P28340 1 +Rhomboid-like superfamily [IPR035952] 0.8162803199672994 2.8533854785523403 0.0043256115694554 0.9873446350434076 0.0131728594018461 3 Q9BUN8 1 +Queuine tRNA-ribosyltransferase-like [IPR036511] 0.7607934655775964 2.793028062780359 0.0052217161709984 0.9948936997183914 0.0151960074316951 2 Q9BXR0 1 +Ricin B-like lectins [IPR035992] 0.7990523837978797 2.7710625015887143 0.0055873700730342 0.996474955137819 0.0159097995299957 3 Q8N4A0 1 +Ribosomal protein L37ae/L37e [IPR011331] 0.7497082847141203 2.7370491384881173 0.0061993032292178 0.9981046418975322 0.017214594091051 2 P61513 1 +NAP-like superfamily [IPR037231] 0.8147108359706691 2.643753275175043 0.0081992397578605 0.9997512103274312 0.0205592877510532 4 P55209,Q99733 2 +RUN domain superfamily [IPR037213] 0.765903054055254 2.610257488652334 0.0090474094994041 0.9998949731517968 0.0222977720669912 3 Q9BQS8 1 +XPC-binding domain superfamily [IPR036353] 0.717327887981334 2.571272553093035 0.010132554827346 0.999965193711787 0.0243181315856306 2 P54725 1 +SNARE [IPR010989] 0.7965557501459231 2.5588305076876523 0.010502493311657 0.999976120685637 0.0250040537925299 4 O15400,Q13277,Q13190 3 +P-type ATPase, A domain superfamily [IPR008250] 0.8229797690050538 2.536446892878383 0.0111983726465285 0.9999882497831912 0.0259202599489326 5 Q9HD20,P16615 2 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.8229797690050538 2.536446892878383 0.0111983726465285 0.9999882497831912 0.0259202599489326 5 Q9HD20,P16615 2 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.8229797690050538 2.536446892878383 0.0111983726465285 0.9999882497831912 0.0259202599489326 5 Q9HD20,P16615 2 +Zinc-binding ribosomal protein [IPR011332] 0.7493434490808335 2.5287235141963653 0.0114478168850269 0.9999908883645748 0.026285647881793 3 P61927,P61513 2 +GOLD domain superfamily [IPR036598] 0.8203243035183867 2.5243242021023193 0.0115920967688849 0.9999921349950056 0.0264962211860227 5 Q15363,Q9Y3B3 2 +Glycoside hydrolase superfamily [IPR017853] 0.7210143673741042 2.5211038609406087 0.0116987316322343 0.9999929454786411 0.0266028511363067 16 O60502,P04062,P16278,Q9BTY2,P54802,P10253 6 +GINS, helical bundle-like domain superfamily [IPR036224] 0.78761603517984 2.516689660886377 0.0118463122295622 0.999993931355076 0.0267737280883379 4 Q9Y248,Q14691 2 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.8328797688425588 2.4776418407506116 0.0132253829642006 0.9999985150450104 0.0289179740301826 7 Q8WUJ1,Q9UMX5,O43169,O15173,O00264 5 +EF-hand domain pair [IPR011992] 0.5054308190225278 2.44203579337103 0.0146046985338625 0.999999637447378 0.0310580930846698 57 P80303,Q9NWM8,P41208,Q02818,O75071,Q14257,Q8IYU8,Q96AY3,P0DP25,O95302,Q9H223,O95202,Q99584,Q9Y680,Q9BRK5 15 +Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784] 0.7221808185322356 2.3932190880980233 0.0167012649505371 0.9999999576391844 0.0342869146031393 3 Q15120 1 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.7551149459513354 2.3616630988264866 0.0181931671995692 0.9999999908323376 0.0366480191033684 4 P42892 1 +Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352] 0.6770711785297621 2.3603865362647434 0.0182559019865009 0.9999999914042162 0.036657269327476 2 Q99735 1 +Ribosomal L18e/L15P superfamily [IPR036227] 0.7122847971987221 2.3433025753962244 0.0191138750316182 0.999999996439262 0.0380015503587202 3 P46776,Q07020 2 +Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151] 0.6726954492415356 2.3371405269638186 0.0194318783489457 0.9999999974320156 0.0385577428656246 2 Q6P6C2 1 +Translation initiation factor IF-2, domain 3 superfamily [IPR036925] 0.6642357059509754 2.292017575745009 0.0219046290021402 0.9999999997985102 0.0418179280949951 2 O60841 1 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.7351985558895104 2.265244901918215 0.023497655099937 0.9999999999610348 0.0438622895198825 4 P55899,P01889 2 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.7351985558895104 2.265244901918215 0.023497655099937 0.9999999999610348 0.0438622895198825 4 P55899,P01889 2 +Histidine phosphatase superfamily [IPR029033] 0.7897596121152957 2.245122962138685 0.0247602398930639 0.9999999999894248 0.0453787669312881 6 Q9NPH0 1 +Tim10-like domain superfamily [IPR035427] 0.6910462185457955 2.2351798134226697 0.025405546202128 0.9999999999945736 0.0462426278153234 3 Q9Y5L4 1 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.7864097093954004 2.229795062353406 0.0257610513544361 0.9999999999962432 0.0466196405121574 6 P55786,Q9UIQ6 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.7864097093954004 2.229795062353406 0.0257610513544361 0.9999999999962432 0.0466196405121574 6 P55786,Q9UIQ6 2 +DNA/RNA polymerase superfamily [IPR043502] 0.7257137316569131 2.2189476304177567 0.0264902875669503 0.999999999998234 0.0474007499956664 4 P28340,Q07864 2 +Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155] 0.647316219369901 2.2010574943316548 0.0277319538878824 0.9999999999995122 0.0488702963618627 2 Q9H267 1 +DNA mismatch repair protein MutS, N-terminal [IPR016151] 0.676101546542173 2.15828725839401 0.030905504750716 0.999999999999982 0.053252562032003 3 P52701,P43246 2 +DNA mismatch repair protein MutS, core domain superfamily [IPR036187] 0.676101546542173 2.15828725839401 0.030905504750716 0.999999999999982 0.053252562032003 3 P52701,P43246 2 +MutS, connector domain superfamily [IPR036678] 0.676101546542173 2.15828725839401 0.030905504750716 0.999999999999982 0.053252562032003 3 P52701,P43246 2 +Moesin tail domain superfamily [IPR008954] 0.675556626537606 2.1554709460890935 0.0311249998133009 0.9999999999999856 0.0533643017791519 3 P35241 1 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.7476877045950605 2.1190594496623096 0.0340854431078403 0.9999999999999992 0.0573591429928264 8 O14678,Q03519,Q9NUT2,Q03518,P08183 5 +Galactose mutarotase-like domain superfamily [IPR011013] 0.6928597132991077 2.0566963927188096 0.0397154393831333 1.0 0.0645696175777394 4 P10253 1 +Isoprenoid synthase domain superfamily [IPR008949] 0.6865882125188705 2.025395027546597 0.0428268176383059 1.0 0.0688507690261761 4 P37268 1 +Six-hairpin glycosidase-like superfamily [IPR012341] 0.6745671419940606 1.9651069938919925 0.0494018553101271 1.0 0.0772047599265243 4 O60476 1 +Alpha/Beta hydrolase fold [IPR029058] 0.5269598284491135 1.8825622229705608 0.059759719973381 1.0 0.0901763439119282 27 Q9NUJ1,P42785,Q9H3G5,P07099,Q8NCC3,P50897,Q9HB40 7 +Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940] 0.7006256896226889 1.8283340306122953 0.0674994354626303 1.0 0.0999110586583427 6 P42345,Q13315,Q13535 3 +SKP1/BTB/POZ domain superfamily [IPR011333] 0.6528307870235797 1.7238912574310432 0.0847274758859584 1.0 0.1196152600742942 5 Q08380 1 +BRK domain superfamily [IPR037259] 0.5892242458846582 1.698471771550752 0.0894187560848065 1.0 0.1251862585187291 3 Q9P2D1 1 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.5400790952955526 1.607880071349253 0.1078614472681676 1.0 0.1475887347980872 19 P78417,Q13505,Q9H7Z7,O15217,Q8TB36 5 +Carboxypeptidase-like, regulatory domain superfamily [IPR008969] 0.5408401400233467 1.607660196403936 0.1079096205815379 1.0 0.1475887347980872 2 O75976 1 +Gamma-glutamyl cyclotransferase-like superfamily [IPR036568] 0.5367561260210104 1.584248658814581 0.1131371441965836 1.0 0.1537948388351329 2 Q8WUX2 1 +Tautomerase/MIF superfamily [IPR014347] 0.5344224037339698 1.570852708733973 0.1162168655607587 1.0 0.156613102253001 2 P14174 1 +HAD superfamily [IPR023214] 0.5103827675593028 1.537345452084463 0.1242087365801085 1.0 0.1649570572763497 22 P49902,Q969T7,P16615,Q9HD20,P20020,Q9BSH5 6 +HAD-like superfamily [IPR036412] 0.5103827675593028 1.537345452084463 0.1242087365801085 1.0 0.1649570572763497 22 P49902,Q969T7,P16615,Q9HD20,P20020,Q9BSH5 6 +Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132] 0.5145857642940577 1.456501983874542 0.1452539015982679 1.0 0.1881952863895296 2 O15382 1 +Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131] 0.5145857642940577 1.456501983874542 0.1452539015982679 1.0 0.1881952863895296 2 O15382 1 +Aminotransferase-like, PLP-dependent enzymes [IPR036038] 0.5145857642940577 1.456501983874542 0.1452539015982679 1.0 0.1881952863895296 2 O15382 1 +MFS transporter superfamily [IPR036259] 0.6000984641452711 1.3877524562830268 0.1652124366964491 1.0 0.2124159900382917 8 Q16625,P53985,Q9H2V7,Q14728,Q96ES6 5 +Spermidine synthase, tetramerisation domain superfamily [IPR037163] 0.5014585764294142 1.380414951092378 0.1674589193875311 1.0 0.2147564767717956 2 P52788 1 +Arrestin-like, C-terminal [IPR014752] 0.4857059509918469 1.2887871292993338 0.1974721017642371 1.0 0.2488148482229387 2 P32121 1 +Acyl-CoA N-acyltransferase [IPR016181] 0.5697179962080754 1.2852200658620043 0.1987153935845897 1.0 0.2497570034080629 10 O14929,O60502,Q86UY6 3 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.5778567788665475 1.2502627607849215 0.2112035770623586 1.0 0.2618612615976106 7 P14735,P22695 2 +RGS, subdomain 2 [IPR044926] 0.5257460546782657 1.192426271795908 0.2330941440506873 1.0 0.2861862328904906 4 O43572,Q9Y5W7 2 +Myosin S1 fragment, N-terminal [IPR008989] 0.5166374781085867 1.144192175211127 0.2525439474674571 1.0 0.3093126355372986 4 Q7Z406,P35579,Q9UM54 3 +Glycosyl hydrolase, all-beta [IPR013780] 0.541777040437775 1.112096620461523 0.2660966096473927 1.0 0.3236670892220698 9 Q9BTY2,P06280,P10253 3 +Cobalamin-binding domain superfamily [IPR036724] 0.4553675612602189 1.111878269715605 0.2661904930209284 1.0 0.3236670892220698 2 Q99707 1 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.4655327319584478 1.0791907820029822 0.2805026880857559 1.0 0.3394318242382257 18 P28072,P49721,P60900 3 +RGS domain superfamily [IPR036305] 0.5199312948518577 1.0486789772506269 0.2943258930707757 1.0 0.3544569895045901 5 O43572,Q9Y5W7 2 +Galactose-binding-like domain superfamily [IPR008979] 0.5205247079924893 1.0244016615536782 0.3056455974949812 1.0 0.3667747169939774 10 P16278 1 +DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599] 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.3702217752457243 2 P18858 1 +Immunoglobulin E-set [IPR014756] 0.4463607100520588 0.9940268361886576 0.3202098025592015 1.0 0.3824306646678615 19 O15031,Q8N3C0,A6NIH7,Q96KP1,O75592,Q13432 6 +Chaperone J-domain superfamily [IPR036869] 0.4428328052629702 0.9707676976131902 0.3316639716595362 1.0 0.394242079519826 19 O75190,O75937,O75165,Q96KC8,Q9Y2G8 5 +AF1104-like superfamily [IPR036075] 0.4302800466744492 0.9660337788237044 0.3340272787569867 1.0 0.3961170552788736 2 Q9NVE7 1 +Oxysterol-binding protein superfamily [IPR037239] 0.520148057215944 0.942400926067132 0.3459874132910716 1.0 0.4093372213584509 6 Q9BXW6 1 +GAR domain superfamily [IPR036534] 0.4206534422403768 0.9104287332880244 0.3625964502090371 1.0 0.4259874380078198 2 Q9UPN3 1 +RNA polymerase Rpb2, OB-fold [IPR014724] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.4271958603744883 3 P30876,Q9H9Y6 2 +DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033] 0.4455792238109287 0.9068754618295004 0.3644726586528373 1.0 0.4271958603744883 3 P30876,Q9H9Y6 2 +Prefoldin [IPR009053] 0.4914248264498971 0.9034509722164152 0.3662865977491427 1.0 0.4288233339502159 5 Q9UBK9,O15212 2 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.5027525974311531 0.8570081431606692 0.3914403842547538 1.0 0.4566804482972127 6 Q13423 1 +ISWI, HAND domain superfamily [IPR036306] 0.4101516919486642 0.8501343892334928 0.3952503741613637 1.0 0.4590004345099708 2 P28370 1 +Malic enzyme, N-terminal domain superfamily [IPR037062] 0.4095682613768947 0.8467981158822036 0.3971076586108999 1.0 0.4606266051551059 2 P48163 1 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.4963016125734536 0.8405333885825053 0.4006093891466746 1.0 0.4641543267354575 7 Q9BUK6 1 +Tubulin, C-terminal [IPR023123] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.5245315223635448 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Tubulin/FtsZ, C-terminal [IPR008280] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.5245315223635448 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.5245315223635448 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Cyclin-like superfamily [IPR036915] 0.4368345959914511 0.7269007732797789 0.4672867434506274 1.0 0.5334371884464693 4 P14635 1 +Cullin homology domain superfamily [IPR036317] 0.4742990654205711 0.7193386235753862 0.4719323036312643 1.0 0.5375228949834062 6 Q13617,Q93034,Q13616,Q13618,Q13620 5 +SNase-like, OB-fold superfamily [IPR035437] 0.4032681645754362 0.6787311694106755 0.4973082129135402 1.0 0.5594717395277328 3 Q9Y2W6,Q7KZF4 2 +Homeobox-like domain superfamily [IPR009057] 0.381766015245614 0.646521439347351 0.5179417171309182 1.0 0.5788084821152611 22 Q96G23,P14859 2 +Band 7/SPFH domain superfamily [IPR036013] 0.4551836923996871 0.6399828754591749 0.5221837325307546 1.0 0.5829027711971213 7 Q9UJZ1,Q99623 2 +Cullin repeat-like-containing domain superfamily [IPR016159] 0.4456140350877132 0.6345810514962752 0.5257016895971938 1.0 0.5861806450375788 10 Q9UPT5,Q8IYI6,Q13619,Q13617,Q93034,Q13616,Q13618,Q13620,Q96MW5 9 +Ribosomal protein L1-like [IPR023674] 0.3880945433323735 0.5997163941640186 0.5486952604638775 1.0 0.6084541502173691 3 O76021,P62906 2 +Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095] 0.3880945433323735 0.5997163941640186 0.5486952604638775 1.0 0.6084541502173691 3 O76021,P62906 2 +SMCs flexible hinge superfamily [IPR036277] 0.4283211678832161 0.5917688549995053 0.5540053816323971 1.0 0.6136674996543475 5 Q14683,A6NHR9,Q9NTJ3,O95347 4 +AH/BAR domain superfamily [IPR027267] 0.3968737000482327 0.5878851857625312 0.5566093606510132 1.0 0.6158751213350399 16 P53367,Q9Y5X3,Q9UQB8 3 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.3718803036168113 0.5799439450063308 0.5619524196508432 1.0 0.6211053059298793 22 Q9UHG3,Q8NB78,Q96CU9,Q14534,Q6NUM9,Q16134 6 +Bromo adjacent homology (BAH) domain superfamily [IPR043151] 0.4051371862230072 0.5689082454374873 0.5694184094263897 1.0 0.626608904696289 4 Q86U86,O94776,P26358 3 +Plakin repeat superfamily [IPR035915] 0.4210218978102236 0.5572829102830434 0.5773341501071991 1.0 0.6339355373726108 5 Q9UPN3,P58107,Q15149,P15924 4 +Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919] 0.3561843640606821 0.5513030777844783 0.5814259289928714 1.0 0.637733771953008 2 P18124 1 +Thioredoxin-like superfamily [IPR036249] 0.3169319717625887 0.5375447773231413 0.5908913636238422 1.0 0.6474114071009054 52 O95881,Q9H3N1,Q9H1E5,P78417,Q9H7Z7,P32119,Q9Y2G8,O43396,O15217,Q8TB36 10 +Nucleotide-diphospho-sugar transferases [IPR029044] 0.3702961667588456 0.5321238643377647 0.5946402099509871 1.0 0.6495184503255754 20 Q8N4A0,O60512 2 +Ribosomal protein S7 domain superfamily [IPR036823] 0.3506417736289404 0.5222051034985541 0.601527533043452 1.0 0.6547945500084229 2 P46782 1 +Fibronectin type II domain superfamily [IPR036943] 0.3474329054842531 0.5055437256397793 0.6131769952450403 1.0 0.6660370810420266 2 Q9UBV2 1 +Kringle-like fold [IPR013806] 0.3474329054842531 0.5055437256397793 0.6131769952450403 1.0 0.6660370810420266 2 Q9UBV2 1 +AP-2 complex subunit mu, C-terminal superfamily [IPR036168] 0.3879159369527211 0.4867294261408997 0.6264500891329274 1.0 0.6797219481657598 4 P48444,Q96CW1,Q9Y2T2 3 +RNA-binding S4 domain superfamily [IPR036986] 0.3835376532399361 0.4663565277103406 0.6409603230181653 1.0 0.6941293037497043 4 Q9Y2Z4,P46781,P62701 3 +SNF2-like, N-terminal domain superfamily [IPR038718] 0.3758109244141543 0.4661536303927747 0.6411055374910464 1.0 0.6941293037497043 16 Q9P2D1,Q9NRZ9,Q86WJ1,O14646,Q9HCK8,Q9H4L7,O14981,Q2NKX8 8 +NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064] 0.3590834724442854 0.4551888650759711 0.6489733705335674 1.0 0.6996418796768299 3 P52429 1 +Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438] 0.3590834724442854 0.4551888650759711 0.6489733705335674 1.0 0.6996418796768299 3 P52429 1 +Sec1-like, domain 3a [IPR043127] 0.385985401459859 0.3990917265101031 0.6898256182365425 1.0 0.7350361767256183 5 Q96AX1,O00186,Q9H267,Q9NRW7 4 +Sec1-like superfamily [IPR036045] 0.385985401459859 0.3990917265101031 0.6898256182365425 1.0 0.7350361767256183 5 Q96AX1,O00186,Q9H267,Q9NRW7 4 +Sec1-like, domain 1 [IPR043154] 0.385985401459859 0.3990917265101031 0.6898256182365425 1.0 0.7350361767256183 5 Q96AX1,O00186,Q9H267,Q9NRW7 4 +Sec1-like, domain 2 [IPR027482] 0.385985401459859 0.3990917265101031 0.6898256182365425 1.0 0.7350361767256183 5 Q96AX1,O00186,Q9H267,Q9NRW7 4 +Beta-grasp domain superfamily [IPR012675] 0.3968439509058614 0.3820899241109246 0.702394665260043 1.0 0.7468500238208052 8 P55039,Q9Y295,Q9BW92,A2RTX5,Q9NTK5,Q9NYK5,P21912 7 +GroES-like superfamily [IPR011032] 0.3928493435658022 0.3806862997679744 0.7034360359734708 1.0 0.7471691509602303 10 Q8N4Q0,Q99536 2 +TGS-like [IPR012676] 0.3967280163599119 0.3753413378328764 0.7074066264820424 1.0 0.7499188828135165 7 P55039,Q9Y295,Q9BW92,A2RTX5,Q9NTK5,Q9NYK5 6 +Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236] 0.3211785297549526 0.3751986212471572 0.7075127555115617 1.0 0.7499188828135165 2 O00443 1 +LEM/LEM-like domain superfamily [IPR011015] 0.3905188967655716 0.3451185316669269 0.7300052621312365 1.0 0.7705186431709805 6 Q86XL3,P42167 2 +Mannose-6-phosphate receptor binding domain superfamily [IPR009011] 0.3470519556333983 0.3069147162304233 0.7589082873943045 1.0 0.7993516757507408 4 P20645,Q13438,P11717 3 +DUSP-like superfamily [IPR035927] 0.3579562043795666 0.2840274274062698 0.77638936179601 1.0 0.8152088298858106 5 Q13107,Q86UV5,Q8NFA0,Q9Y4E8 4 +MIT domain superfamily [IPR036181] 0.3382953882078297 0.2719057634776723 0.7856944795329104 1.0 0.8207046998644286 4 Q8N0X7,Q6PHR2,O75351 3 +FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156] 0.3228254524226572 0.2137343500933605 0.8307542227569549 1.0 0.8632992335453716 4 O95831,Q16881,P09622 3 +Longin-like domain superfamily [IPR011012] 0.3466939730836777 0.2120363617462467 0.8320786666532611 1.0 0.8637850628079168 12 O75396,Q9Y296,O15498,P53680,P61923,P51809,Q92572,Q96CW1,Q9BXS5,P48444,Q9Y2T2 11 +Zinc finger, Sec23/Sec24-type superfamily [IPR036174] 0.2859109522186515 0.1534100449004617 0.8780749239678358 1.0 0.9050097375864812 3 O95487 1 +WWE domain superfamily [IPR037197] 0.2830463962649669 0.1440902460991764 0.8854292068314711 1.0 0.9107271841695131 3 Q7Z6Z7,Q7Z2W4 2 +ARFGAP/RecO-like zinc finger [IPR037278] 0.3061906107663186 0.0633963527078726 0.9494508915284754 1.0 0.9696519743269536 7 Q8IYB5,Q15057 2 +ArfGAP domain superfamily [IPR038508] 0.3061906107663186 0.0633963527078726 0.9494508915284754 1.0 0.9696519743269536 7 Q8IYB5,Q15057 2 +NTF2-like domain superfamily [IPR032710] 0.296672750936276 0.0363723322399374 0.9709854752506192 1.0 0.9896393923686798 8 P61970,Q9BRJ2 2 +Ribonuclease H superfamily [IPR036397] 0.2889798760156953 0.0209790268752306 0.9832623861231566 1.0 0.9981152922579476 13 P28340,Q07864 2 +Protein kinase-like domain superfamily [IPR011009] 0.2642638548960112 0.018291583052029 0.9854062420961572 1.0 0.999285203252441 91 P54646,Q13546,P42345,Q13535,P11802,Q14012,P50750,P06493,Q13315,P78527,Q00535,P51812,P48729,Q15418,O14965,Q96GX5 16 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..76b870350a0ffb7d216214ca27f1b15ef9a08192 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adaptor protein Cbl, N-terminal domain superfamily [IPR036537]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Alba-like domain superfamily [IPR036882]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha-macroglobulin, receptor-binding domain superfamily [IPR036595]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin, N-terminal [IPR014753]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "Atg6/Beclin C-terminal domain superfamily [IPR038274]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Bcr-Abl oncoprotein oligomerisation domain superfamily [IPR036481]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CBP/p300, atypical RING domain superfamily [IPR038547]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CENP-B, dimerisation domain superfamily [IPR034882]", "CGI121/TPRKB superfamily [IPR036504]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Calycin [IPR012674]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carbon-nitrogen hydrolase superfamily [IPR036526]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Caspase-like domain superfamily [IPR029030]", "Catenin binding domain superfamily [IPR027397]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chondroitin AC/alginate lyase [IPR008929]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coactivator CBP, KIX domain superfamily [IPR036529]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Copper homeostasis (CutC) domain superfamily [IPR036822]", "Core-binding factor, beta subunit superfamily [IPR036552]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily [IPR037008]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit VIb superfamily [IPR036549]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DENN domain, C-terminal lobe [IPR043153]", "DHBP synthase RibB-like alpha/beta domain superfamily [IPR017945]", "DHH phosphoesterase superfamily [IPR038763]", "DHHA2 domain superfamily [IPR038222]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Daxx, N-terminal domain superfamily [IPR038298]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "DhaL domain superfamily [IPR036117]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 2 [IPR042264]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3 ubiquitin-protein ligase ELL-like [IPR042065]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "ESCRT-II complex, Vps25 subunit, N-terminal winged helix [IPR014041]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "EYA domain superfamily [IPR038102]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exocyst component Exo84, C-terminal, subdomain 1 [IPR042561]", "Exocyst component Exo84, C-terminal, subdomain 2 [IPR042560]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD-linked oxidoreductase-like [IPR029041]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FMN-binding split barrel [IPR012349]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Folliculin, DENN domain, C-terminal superfamily [IPR044886]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GBBH-like, N-terminal domain superfamily [IPR038492]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP cyclohydrolase 1 type 2/Nif3 superfamily [IPR036069]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GTPase HflX, N-terminal domain superfamily [IPR042108]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Globular protein, non-globular alpha/beta subunit [IPR011070]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "Golgi phosphoprotein 3-like domain superfamily [IPR038261]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like, capping domain superfamily [IPR044924]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix hairpin bin domain superfamily [IPR029012]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "HesB-like domain superfamily [IPR035903]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin alpha, N-terminal [IPR028994]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MAP kinase activated protein kinase, C-terminal [IPR027442]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTERF superfamily, mitochondrial/chloroplastic [IPR038538]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Mediator complex, subunit Med7/Med21-like [IPR037212]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mog1/PsbP, alpha/beta/alpha sandwich [IPR016123]", "Molybdopterin biosynthesis MoaE subunit superfamily [IPR036563]", "Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily [IPR036522]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Ndc80 domain superfamily [IPR038273]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Notch-like domain superfamily [IPR035993]", "Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily [IPR037073]", "Nuclear receptor coactivator, interlocking [IPR009110]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PHR domain superfamily [IPR038648]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLAT/LH2 domain superfamily [IPR036392]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PLP-binding barrel [IPR029066]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pectin lyase fold [IPR012334]", "Pectin lyase fold/virulence factor [IPR011050]", "Pelota/DOM34, N-terminal domain [IPR038069]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosducin, N-terminal domain superfamily [IPR023196]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Plus3-like superfamily [IPR036128]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RGS, subdomain 1/3 [IPR024066]", "RGS, subdomain 2 [IPR044926]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily [IPR038085]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RUN domain superfamily [IPR037213]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Rap/Ran-GAP superfamily [IPR035974]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rel homology domain (RHD), DNA-binding domain superfamily [IPR037059]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L20, C-terminal [IPR035566]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S16 domain superfamily [IPR023803]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S18 superfamily [IPR036870]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rubisco LSMT, substrate-binding domain superfamily [IPR036464]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SATB, CUTL domain superfamily [IPR038216]", "SATB, ULD domain superfamily [IPR038224]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Set2 Rpb1 interacting domain superfamily [IPR038190]", "Seven-hairpin glycosidases [IPR036026]", "Sialidase superfamily [IPR036278]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Soluble quinoprotein glucose/sorbosone dehydrogenase [IPR011041]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "TAP42/TAP46-like superfamily [IPR038511]", "TAZ domain superfamily [IPR035898]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Taurine dioxygenase TauD-like superfamily [IPR042098]", "Tautomerase/MIF superfamily [IPR014347]", "Telomere repeat-binding factor, dimerisation domain superfamily [IPR036507]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonine synthase, N-terminal domain superfamily [IPR037158]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Toll/interleukin-1 receptor homology (TIR) domain superfamily [IPR035897]", "Transcription Factor IIF, Rap30/Rap74, interaction [IPR011039]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription factor EnY2 superfamily [IPR038212]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "Tryptophan synthase beta subunit-like PLP-dependent enzyme [IPR036052]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 [IPR042522]", "Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 [IPR042523]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily [IPR042556]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS28, C-terminal domain superfamily [IPR037206]", "VPS28, N-terminal domain superfamily [IPR038358]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "XRCC4, N-terminal domain superfamily [IPR009089]", "XRCC4-like, N-terminal domain superfamily [IPR038051]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain [IPR044920]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADO", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMPD2", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANKRD17", "ANKS1A", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEH", "APEX1", "API5", "APIP", "APMAP", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL15", "ARL2", "ARL3", "ARL8A", "ARL8B", "ARMC1", "ARMC10", "ARMC6", "ARMC8", "ARMC9", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "AS3MT", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATR", "ATXN10", "AURKA", "AURKB", "B4GALT3", "BABAM1", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAS3", "BCAT1", "BCAT2", "BCKDHB", "BCKDK", "BCL2L13", "BCR", "BCS1L", "BDH2", "BECN1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BROX", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BZW1", "BZW2", "C1QBP", "C2CD2L", "C2CD5", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPV", "CEP170", "CEP97", "CERS2", "CETN2", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHM", "CHORDC1", "CHRAC1", "CHTF18", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLSTN3", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT4", "CNOT7", "CNP", "COA7", "COASY", "COG8", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENND5B", "DENR", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH1", "DPH2", "DPH5", "DPM1", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSE", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFHD2", "EFL1", "EFR3A", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120A", "FAM120B", "FAM129B", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FBL", "FBXL18", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCDH", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNPNAT1", "GNS", "GOLPH3", "GORASP2", "GOT1", "GOT2", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTCD", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP6", "GTPBP8", "GUF1", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMG20A", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK1", "HP1BP3", "HPRT1", "HPS5", "HS1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS4", "INTS6", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRS4", "ISCA2", "ISG20L2", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITPA", "ITSN2", "IVD", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA1468", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC14", "LRRC40", "LRRC41", "LRRC47", "LRRC57", "LRRC59", "LRRC8A", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1A", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCRS1", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED16", "MED21", "MEPCE", "METAP2", "METTL13", "METTL25", "METTL7B", "MFGE8", "MFN1", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOCS1", "MOCS2", "MOCS3", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPDZ", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL4", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCBP1", "NCBP2", "NCBP3", "NCDN", "NCKIPSD", "NCL", "NCOA5", "NCOR1", "NDC80", "NDRG1", "NDRG3", "NDUFA10", "NDUFA2", "NDUFA9", "NDUFAF3", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEK9", "NELFE", "NENF", "NET1", "NEU1", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP37", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEBP1", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHLDB2", "PI4KA", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLEC", "PLEKHA5", "PLEKHA7", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POMGNT2", "PON2", "POR", "POU2F1", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPFIBP1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REL", "RELA", "REPS1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIPK1", "RMC1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRM1", "RRM2", "RRP12", "RRP7A", "RRP8", "RRP9", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACS", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SATB2", "SBDS", "SBNO1", "SCAF11", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL1", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SH3RF1", "SHCBP1", "SHMT1", "SHMT2", "SHPRH", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMS", "SMU1", "SMYD3", "SMYD4", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPR", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX12", "STX3", "STX5", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUMO2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TENM3", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFRC", "THADA", "THNSL1", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TMA16", "TMED2", "TMED5", "TMED7", "TMLHE", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP1", "TPBG", "TPD52L2", "TPI1", "TPM4", "TPMT", "TPP1", "TPP2", "TPRKB", "TPT1", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBL7", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIPAS39", "VIRMA", "VKORC1L1", "VPS16", "VPS25", "VPS26A", "VPS28", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK2", "VRK3", "WAPL", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR35", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR47", "WDR48", "WDR5", "WDR6", "WDR61", "WDR62", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WNK1", "WRAP53", "WRAP73", "WWP2", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO6", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YES1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZCCHC11", "ZCCHC3", "ZCRB1", "ZFR", "ZFYVE16", "ZMAT2", "ZNF281", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2"], "leading_proteins": ["ABCB1", "ABCB8", "ABCD4", "ABHD10", "ACAP2", "ACP6", "AIFM1", "AKAP10", "ALKBH5", "ANKLE2", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "ARCN1", "ARFIP1", "ARRB2", "ARSA", "ASCC3", "ATM", "ATP13A1", "ATP2A2", "ATP2B1", "ATR", "AURKA", "B4GALT3", "BAIAP2", "BAX", "BCAT2", "BCL2L13", "BTAF1", "CALM3", "CAMK1", "CCNB1", "CDK1", "CDK4", "CDK5", "CDK9", "CERS2", "CETN2", "CHAC2", "CHD1", "CHD1L", "CHD7", "CHD8", "COG8", "COPZ1", "CPD", "CPVL", "CSNK1A1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYP20A1", "DCUN1D1", "DCUN1D4", "DERL1", "DGKE", "DHCR24", "DLD", "DNAJB6", "DNAJC1", "DNAJC13", "DNAJC16", "DNAJC8", "DNMT1", "DRG1", "DRG2", "DSP", "ECE1", "EFCAB14", "EHD4", "EIF5", "EIF5B", "EPHX1", "EPPK1", "ERCC6L", "ETFDH", "EXOC2", "EXOC7", "EXOC8", "FCGRT", "FDFT1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FOXRED1", "FUCA2", "FYCO1", "GAA", "GALNT4", "GBA", "GDAP1", "GINS1", "GINS2", "GLA", "GLB1", "GSTA4", "GSTO1", "HAT1", "HDHD3", "HELLS", "HLA-B", "HMOX2", "HUWE1", "IDE", "IGF2R", "KDM1B", "LETM1", "LGALS3BP", "LIG1", "LNPEP", "LSS", "M6PR", "MACF1", "MAGED1", "MAN1A2", "MASTL", "ME1", "MFSD10", "MFSD3", "MGEA5", "MGST2", "MICU2", "MIF", "MRPL39", "MRPL45", "MSH2", "MSH6", "MSTO1", "MTA2", "MTCH1", "MTCH2", "MTOR", "MTR", "MTX1", "MYCBP2", "MYH14", "MYH9", "MYO6", "NAA40", "NAGLU", "NAP1L1", "NAP1L4", "NENF", "NNT", "NPEPPS", "NT5C2", "NT5C3B", "NUCB1", "NUCB2", "NUTF2", "OCLN", "OLA1", "OS9", "OSBPL1A", "PANK4", "PARP2", "PBRM1", "PCYOX1", "PDK3", "PFDN6", "PGRMC1", "PGRMC2", "PHB2", "PIK3C2A", "PLA2G15", "PLEC", "PLXNB2", "POLD1", "POLE", "POLR1B", "POLR2B", "POU2F1", "PPT1", "PRCP", "PRDX2", "PRKAA2", "PRKDC", "PSMA6", "PSMB2", "PSMB6", "PTGES2", "QTRT1", "RAD23A", "RCN2", "RDX", "RETSAT", "RIPK1", "RPL10A", "RPL18", "RPL27A", "RPL37", "RPL37A", "RPL7", "RPS24", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RSL1D1", "S100A13", "SCPEP1", "SDF4", "SDHB", "SEC22B", "SEC24B", "SEL1L", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A6", "SMAP1", "SMARCA1", "SMARCAD1", "SMC1A", "SMC2", "SMC4", "SMCHD1", "SMS", "SND1", "SNX14", "SNX5", "SPART", "SPNS1", "SQLE", "STOML2", "STX3", "STX5", "STX7", "STXBP3", "TAP1", "TAP2", "TARS2", "TARSL2", "TDRKH", "TIMM13", "TMED2", "TMED7", "TMPO", "TMX1", "TMX4", "TRAPPC4", "TSPAN3", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "TXNDC12", "TXNL1", "TXNRD1", "ULK3", "UNC119", "UNC119B", "UQCRC2", "USP15", "USP32", "USP4", "USP48", "UXT", "VAMP7", "VAT1", "VDAC1", "VDAC2", "VPS33A", "VPS33B", "VPS45", "VPS4B", "YARS2", "YKT6", "ZADH2", "ZC3HAV1"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..051f9bf12be96b571a6c230d8fbfcea0ac5435c6 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:56f7366659babb0680fda312a1d71c0d7991e60e0b2d7f5a13d38850308c1dbe +size 76681 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5b6f59aad154fed659766b9fd72992d9097134e6 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P-type ATPase, phosphorylation site [IPR018303] 2 5 2.536446892878383 0.0111983726465285 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.0 1.0 1.0 0.4172977923286156 0.0892170338783466 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..aaa00009cb659b91a21206b613845d12b191f78c --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.5 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5ae3e4fb7ef98b065f570148be02239a68301d19 --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a353badd30aa7dfbfe94b2f8f19adcf34f3eb084 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.8229797690050538 2.536446892878383 0.0111983726465285 0.0440466708232141 0.0223967452930571 5 Q9HD20,P16615 2 +EGF-type aspartate/asparagine hydroxylation site [IPR000152] 0.3341114677560595 0.3401680241994275 0.7337299968324789 0.9949732304715058 0.7337299968324789 3 Q04721,O94813 2 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d46bb86b58b42ef3d986049f08f7b5e80beb6a34 --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "EIF5A", "FASN", "LRP1", "NOTCH2", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP2A2", "NOTCH2", "SLIT2"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2c37b2b7a483ff56a143ea08a567978dfc528150 --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:49b3b26f33615ddbdff76adc8b12659260eb08b0fe265eb8b67b9467e809b86c +size 187145 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6e9089e8355813897ebc686eeb828210057d2044 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]", "1": "HEAT repeat [IPR000357]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..b69614b724836e3b1a47dec1f9b516826360fe58 --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:29b0bbd98f3716a7e79b92250a6dace1c1c8666d9c85f37fc2e4672da274c031 +size 149226 diff --git a/interpro_repeat/basic/plot_1.png b/interpro_repeat/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..2049d94026d799bbb4578f7baf3693cc39761c81 --- /dev/null +++ b/interpro_repeat/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:02611e10b728dd990212f65d35259c9b65242a47f6b7663eeec09c617ea45a3a +size 140448 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..fc76c9031b0b934874351e00df7146526aa82756 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a10b6baf7f4199b59da1c45444a340d84cf5dc617607202093874712c809265a +size 94628 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cf8ac98c6f306d1aa74060a0a5970b0b7115c614 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 12 20 3.134812262604202 0.0017196412523967 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.2674108336121077 1.0 0.0513963234576887 2.19272845709178e-07 1.3245802425307256e-08 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..18e4f5636bb14bb97c3e0b7a7a2a20cd44202d23 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 79, + "title": "Average number of proteins per term", + "value": 5.886075949367089 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..002c88f165f6854ff52f938791850fea12670b94 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7c06149ccec71b0078737ce8ab35c32fed8de691 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.7833267581492319 3.134812262604202 0.0017196412523967 0.1271299607673983 0.0062534852734495 20 Q70HW3,Q9BSK2,Q9Y6C9,Q9Y619,Q9UBX3,O43808,Q9NZJ7,Q9BQT8,O43772,P12236,P12235,Q9H2D1 12 +Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547] 0.4286548001167357 0.8145621844198793 0.4153229637820477 1.0 0.4621199174476305 3 Q00610,Q8WUH2 2 +Plectin repeat [IPR001101] 0.4210218978102236 0.5572829102830434 0.5773341501071991 1.0 0.6001236560324833 5 Q9UPN3,P58107,Q15149,P15924 4 +HEAT repeat [IPR000357] 0.3355724299065525 0.1483941811719376 0.882031691984744 1.0 0.893339790599933 6 Q8TF05,Q6PJG6,P30154,O00410,Q8TEX9 5 +HEAT, type 2 [IPR021133] 0.3079880145240122 0.0975676665627869 0.9222756003158724 1.0 0.9222756003158724 14 Q92616,Q86Y56,Q13535,Q8TEX9 4 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ce2e9551007f1a849763cac121e9a0f834fd4b5a --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Beta-propeller repeat TECPR [IPR006624]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "FG-GAP repeat [IPR013517]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "Integrin alpha beta-propellor [IPR013519]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "MORN motif [IPR003409]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "Opioid growth factor receptor repeat [IPR006770]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Parallel beta-helix repeat [IPR006626]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "YD repeat [IPR006530]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "ACAP2", "ACTN1", "ACTN2", "ACTN4", "AGAP3", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKRD13A", "ANKRD17", "ANKS1A", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC1", "ARMC6", "ARMC8", "ARMCX3", "ARPC1A", "ARPC1B", "ARVCF", "ASPH", "ATR", "BARD1", "BIRC6", "BOP1", "BRAT1", "BUB3", "CAST", "CDC16", "CDC23", "CDC27", "CDC40", "CEP97", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "CNOT10", "COA7", "COPA", "COPB2", "CORO1B", "CORO1C", "CORO7", "CRNKL1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DTL", "DYNC1I2", "EDC4", "EHMT1", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "ERBIN", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GMPPB", "GNB1", "GNB1L", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HERC2", "HTT", "HUWE1", "IFIT5", "IGF2R", "ILK", "INTS4", "IPO4", "IPO5", "ITGA6", "ITGAV", "JUP", "KAT7", "KATNB1", "KDELC2", "KDM2A", "KIAA1468", "KIDINS220", "KLC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LARP1", "LASP1", "LLGL1", "LRBA", "LRCH2", "LRP1", "LRPPRC", "LRRC1", "LRRC14", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8A", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MED16", "MKI67", "MRPS27", "MTCH1", "MTCH2", "MTPN", "MYCBP2", "NAA15", "NASP", "NEK9", "NHLRC2", "NIPBL", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NOTCH2", "NUP214", "NUP37", "NXF1", "OGFR", "OGT", "OSBPL1A", "P4HA1", "P4HA2", "PAFAH1B1", "PAK1IP1", "PDCD11", "PEX5", "PHIP", "PIK3R4", "PKP2", "PLAA", "PLEC", "PLRG1", "PLXNB2", "POLR2A", "PPID", "PPP1R12A", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP4R1", "PPP5C", "PPWD1", "PREB", "PRKCSH", "PRMT9", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABGGTA", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RAP1GDS1", "RBBP4", "RBBP5", "RBBP7", "RCC1", "RCC2", "RNH1", "RPAP3", "RRP9", "RSU1", "SART3", "SCML2", "SCRIB", "SEC31A", "SEL1L", "SETD7", "SFMBT1", "SGTA", "SHCBP1", "SIN3A", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SPTBN2", "SRP72", "STIP1", "STRAP", "STRN", "STUB1", "SUGT1", "SYNE2", "TAGLN2", "TBL2", "TBL3", "TENM3", "TEX10", "TGFBRAP1", "THOC3", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TONSL", "TPBG", "TRIO", "TTC1", "TTC19", "TTC26", "TTC27", "TTC28", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "VPS18", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR35", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR47", "WDR48", "WDR5", "WDR6", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Transmembrane transport 90 213 4.964943575787215 6.87210465383364e-07 67.45631067961165 211.1359223300971 1.8122664376950308 0.3598356673827246 27.267027885156203 22.354947126810902 2.251277763144546 0.4188333713481413 1.3994448413002597e-05 0.0371764295831398 1.0253621290577795e-05 3.312394699038313e-09 6.765671034701793e-12 +Mitochondrion organization 64 200 4.5633147269678735 5.035224525107296e-06 56.45873786407767 188.26941747572815 1.5905300936136977 0.4100157441778524 20.15716756472138 18.40319032732565 2.034523716094369 0.4327537677377048 1.8749280429641544e-06 3.98760466822691e-05 1.3564595567674006e-07 1.2026105314719203e-09 2.7838431918692573e-15 +Ion transmembrane transport 64 154 4.141143868436935 3.455781097794208e-05 47.09466019417476 154.11893203883494 1.555073205784263 0.3634279635891347 19.61122797656 15.97124025754773 1.9676287128633565 0.411597796705808 0.032075282889212 0.0719964500369297 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lipid metabolic process 14 37 3.5685169884074965 0.0003590075791022 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 0.0004228805129556 0.4475497772550058 1.894542429724291e-05 1.8637621836260826e-07 1.8873603096786298e-05 +Sphingolipid metabolic process 15 28 3.528775596271673 0.000417486985156 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 0.0001114958760535 0.3713777336871285 3.079597095472993e-06 3.804615438664537e-07 1.0774019052855377e-05 +Mitochondrial transport 26 85 3.520854101377344 0.0004301592264195 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 1.0773779088303397e-07 1.6637908505492858e-05 6.034652924825416e-07 4.1685470633929255e-09 2.4309583419588643e-09 +Steroid metabolic process 23 71 3.464969285705618 0.0005302920392391 17.82766990291262 66.9247572815534 0.9974586731388552 0.3270410156332073 6.090491666967852 5.93996409793671 1.7133199907504504 0.3720334828404655 0.0002690164303235 0.007032737188996 0.000740619861068 6.385325127353915e-09 3.0827465980310373e-08 +Lipid localization 19 80 3.4224896640878253 0.0006205045689109 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 7.334272573783573e-05 0.0043835120706257 0.0002652349105109 0.0003082164034328 0.0004782064893172 +Mitochondrial transmembrane transport 25 51 3.360658020095409 0.0007775703667345 19.070388349514563 50.63834951456311 1.9310146760091371 0.188342667216329 9.760351579527285 3.939196260509299 1.9786128158557912 0.3017981993827387 0.0006235932260289 0.0082661149627475 0.00132313066272 1.1325122383507624e-07 8.275211369181008e-12 +Lipid metabolic process 91 294 3.357033460871764 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0.0012769803569745 12.097087378640778 42.24514563106796 1.5200936296432006 0.2566232504859334 4.463475425703621 3.883072640851752 1.3223501002339118 0.3210874999447533 0.0006936057453806 0.0088103554061084 0.0014681571022129 1.8601903634898852e-08 6.918933611170777e-10 +Organic anion transport 20 43 3.2034372604016217 0.0013579762501023 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 0.112551071765936 0.5097893650742695 0.1608702453512187 0.0237635173186347 0.004382947516926 +Organic acid transmembrane transport 13 29 3.057794605603235 0.0022297234750208 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 0.1380746617495529 1.0 0.1793408912067547 0.0128484864032106 0.0016376917698255 +Protein insertion into membrane 14 29 3.040752561319751 0.0023598767937946 9.861650485436892 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46.91019417475728 1.283632855732258 0.3380738792929293 7.413069190635445 4.027718639381892 1.6948461264793506 0.367302285357348 0.0076920997462726 0.0803423183551439 0.0135945544498884 0.0001051927101865 1.4182707409980816e-07 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 8 27 2.9877118598391084 0.0028107440989364 7.771844660194175 26.825242718446603 1.1714448828781496 0.3436005361805324 3.811248488859092 3.450558374586287 1.1733172803389544 0.345676809182098 0.0065179254011117 0.2067156970649581 0.0102837000876808 0.0265672828357611 0.0003749043951495 +Nitrogen compound transport 132 608 2.9374071771911368 0.0033096923475366 134.15533980582524 569.4538834951456 0.9072063241864304 0.6401677607980054 37.1767641393764 58.81145048559368 1.470232145086419 0.4303798393104362 0.029012650982327 0.2359259720445035 0.113476237859952 1.639393994280189e-05 5.682579086708766e-09 +Regulation of autophagy 30 103 2.9269859334343 0.0034226436053357 20.118932038834952 94.3495145631068 0.711099590941891 0.531831837860264 6.9602150135047 11.998348379757145 0.9791686068293384 0.3767967479294735 0.0065751488703143 0.1482089148241369 0.0045852906967846 0.0009457395915819 0.0003422811587161 +Cation transmembrane transport 45 120 2.926647571680444 0.0034263690869382 33.43446601941748 118.4004854368932 1.1701058025505957 0.4085228823574113 14.425169362008605 12.553856783980793 1.6663185381795875 0.4066910074955585 0.5919493533809143 0.5523721853115487 0.2906543576379714 0.0094839223449001 6.946338564884106e-05 +Lytic vacuole organization 9 24 2.926455899062615 0.0034284811071383 8.677184466019417 23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 2.0111064761459874 0.2496786569477077 0.0014079806447729 0.0348230103466341 0.0025924072114898 9.122299302310884e-05 0.000128953401209 +Membrane lipid biosynthetic process 8 22 2.8967111918751187 0.003770967312648 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 0.0290764176033249 1.0 0.0079219249747297 0.0001558609137303 0.0063151145893543 +Protein targeting 26 118 2.880783055613234 0.0039668858047627 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 0.0001931344745094 0.001344211716398 0.0006716226852438 3.793436929579559e-05 1.3074198992740306e-05 +Establishment of protein localization to membrane 25 89 2.8729943119029797 0.0040660143700477 23.133495145631063 87.3616504854369 1.231448880072231 0.4195243824117992 8.397245527204214 9.510228790351464 1.3947369206386535 0.4065372973031916 0.0846190597046506 0.2643557331790067 0.1330886303833328 0.0040246499403502 1.895556368394642e-05 +Protein targeting to mitochondrion 15 46 2.867961203230733 0.0041312618946904 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 7.714542201614186e-05 0.0008814481157451 0.0001940435749139 4.9861626098174725e-05 4.455669256984436e-06 +Membrane organization 65 227 2.856355218885162 0.0042853539729608 62.02427184466019 223.60922330097088 0.9560408776070136 0.5603311757674675 21.467957454898308 21.375973545731355 1.611091026762519 0.4273954777865132 0.0104544366957356 0.1158907814307528 0.0124138798540382 0.0010391563622735 1.531808060477643e-07 +Inorganic anion transport 11 25 2.819704948609576 0.0048067824497255 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 0.0002364972280536 0.0003498925816777 0.0005115527825537 0.0063798653120075 0.000109411165682 +Sphingolipid biosynthetic process 6 15 2.816749265724466 0.0048512381928851 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 0.0121881103755932 1.0 0.0024373211620913 0.0005241078784284 0.0074744155515412 +Maintenance of protein localization in endoplasmic reticulum 2 5 2.812679472805239 0.0049130597628392 1.203883495145631 3.203883495145631 1.1364527439994954 0.2609157960586762 1.0226486010276945 1.0226486010276945 1.138989616014889 0.2624735143617788 0.0017758793795144 0.0385773062479974 0.002465796513642 0.0007187465088185 0.0053637976870067 +Protein retention in er lumen 2 5 2.812679472805239 0.0049130597628392 1.203883495145631 3.203883495145631 1.1364527439994954 0.2609157960586762 1.0226486010276945 1.0226486010276945 1.138989616014889 0.2624735143617788 0.0009614964335136 0.0290719737908623 0.0013376518177504 0.0002661275452166 0.002061539822863 +Organophosphate ester transport 12 25 2.807411489258559 0.0049941402036723 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.0264151659552541 0.0571768496395965 0.0402942577421927 0.002958524345255 0.0014756922477904 +Steroid biosynthetic process 14 49 2.7993556526415757 0.005120470468144 11.728155339805824 44.80825242718446 0.9874364787035632 0.3935759881445143 5.016369659264937 4.35272817633461 1.2862817592315925 0.3680333006848349 0.0444225207934893 0.0118439766153403 0.0665208936004256 0.0001148285236693 3.7971450805776782e-06 +Hormone metabolic process 11 29 2.795706497579628 0.0051786406745728 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 0.0011354799598462 0.0817843887077026 0.0023748989920053 0.0023912319011254 0.0025711434786665 +Establishment of protein localization 116 561 2.790457823544364 0.0052633557214882 118.26941747572816 516.7257281553398 0.6520395559374618 0.679532677582667 31.472560658738065 53.21298128179791 1.2523101724416292 0.4083128036600569 0.0423784780232572 0.2638114371450886 0.0858768888173364 0.0001993708709177 1.03617067645322e-07 +Ceramide metabolic process 9 18 2.7897977425887377 0.0052740977584802 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 0.0784025564630051 1.0 0.0021465314893355 6.271742480254313e-05 0.0003775126449021 +Vacuole organization 11 53 2.7796585555437416 0.0054416081267278 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.0374493013614101 0.1760534030430948 0.0620226994518361 0.0130564574399452 0.0190321006877833 +Endoplasmic reticulum organization 15 43 2.775946314111001 0.005504129623955 14.91747572815534 43.67718446601942 1.1418424810127707 0.3725584991544436 6.208589840117394 4.768440325801463 1.6823827875834556 0.3705219831566139 0.1270753973132237 0.312708212996757 0.1656331484196294 0.000481912947582 3.058495644549428e-06 +Regulation of hormone levels 17 68 2.7665774182839606 0.0056648132601446 15.682038834951456 62.25485436893204 0.7754141622249116 0.4638741971732045 6.630568201753413 6.49574922456989 1.111399769110166 0.3798141702267368 0.0317566879561074 0.2881021086306851 0.0578004734830958 0.0384014534154076 0.0192177365217959 +Sulfur compound transport 2 6 2.7539956324990995 0.0058872553793412 3.504854368932039 9.429611650485436 1.339223354728307 0.2167503093092372 2.046184165461596 2.1092484385198076 1.0728301411615704 0.2604171804663498 0.0293662469729552 0.1499686155438198 0.0038117145357013 0.0449350347407693 0.2160393117631846 +Regulation of ligase activity 0 5 2.7303232775167423 0.0063272246183783 1.6189320388349515 3.657766990291262 -0.1309740456000647 0.5697887055852975 1.116048344832176 0.953716727436356 0.9183062283380776 0.3007789964561075 0.0785196824488724 0.0479914252810258 0.0921025797166938 0.2175647207167039 0.3934410105686676 +Cation transport 54 160 2.7173716214526675 0.0065802677589226 40.9247572815534 152.4733009708738 1.0106305648473772 0.4693050539746304 15.98502541638414 15.374508146736815 1.5607432077940149 0.4143686874753333 0.3802932767346754 0.4430646629542071 0.2007956306823712 0.0092721899351048 0.0001661234817993 +Chemical homeostasis 54 187 2.6996529129219144 0.0069411849402176 43.762135922330096 177.7597087378641 0.7082111793088889 0.511106347874914 13.668464281922288 17.87763227716401 1.3204137511810292 0.4179418895476048 0.0370298149129592 0.0539818023751681 0.041417693164293 0.0044579605086261 0.0002989704755499 +Vitamin transport 4 6 2.6978042425865847 0.0069798471834168 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.0160900301160464 1.0 0.0219975904219434 0.0002335266734922 0.0053032680205866 +Carboxylic acid transport 12 32 2.6956135448779976 0.0070259127541989 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.2104948645013735 1.0 0.2676422850845579 0.1112177727483601 0.031782258480817 +Inorganic ion transmembrane transport 41 115 2.6930625114287907 0.0070798993327285 32.300970873786405 111.99514563106796 0.9881513097876132 0.4268253140664947 13.185263141323642 11.586314982845243 1.7161030277526947 0.4113555760685328 0.3034313614382021 0.503744846191468 0.2321607404953994 0.0192862853602071 0.0001328927425967 +Sphingoid metabolic process 3 5 2.6838432639840653 0.0072781217914523 2.337378640776699 5.174757281553398 0.8258730035764346 0.2192038420096116 1.196784089801513 0.5941001920342514 1.4738240163378542 0.2563928956394505 0.0028240506634377 1.0 0.0039135152062846 0.001485709034831 0.0009257875785001 +Organic acid transport 16 46 2.670631272787708 0.0075708761612967 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 0.3069800654544993 1.0 0.3803883597337516 0.1154859850799389 0.0068680599881591 +Establishment of protein localization to mitochondrial membrane 10 19 2.660471440314094 0.0078031344625715 5.572815533980583 16.524271844660195 1.1986544459127668 0.291784793504827 2.8501471321161915 2.5441524813639957 1.2232399066733852 0.3232066755573589 0.0201433177792313 0.1244478155008913 0.0274603336438859 0.0004179970223822 2.1189513680548986e-08 +Lipid biosynthetic process 58 154 2.644785720153446 0.0081742663053996 38.012135922330096 141.7257281553398 0.5620793375816577 0.4367444072022249 15.729119254593195 17.314902336322657 1.553306672697969 0.3832082090559359 0.0219878437088832 0.1541980220314314 0.0075465906671422 4.207171139260067e-06 6.467458642885282e-07 +Carbohydrate derivative transport 8 13 2.642845444211437 0.0082212553579779 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 0.0061375020920263 0.2027885470531376 0.0096938597365547 0.0007908116200209 0.0015279037069893 +Protein localization to endoplasmic reticulum 7 36 2.613276500055603 0.0089678717178396 9.50242718446602 34.50485436893204 0.9935384348474128 0.428255638055916 4.399083524593319 2.6617527855555916 1.1934894982037212 0.3717243536861919 0.0110979142419323 0.2449590299452383 0.0173242512102645 0.000423196822916 0.0003775126449021 +Amyloid precursor protein metabolic process 6 20 2.613138084636643 0.0089715046566896 5.91747572815534 20.04368932038835 1.2306110398413417 0.2828388345239639 2.574706211328507 3.0661056512526157 1.0127867956133585 0.2841981221806073 0.0737029175928528 0.0296703391700837 0.0978881295505725 0.0020419820824666 0.0167583931949217 +Nucleotide transmembrane transport 6 8 2.609462357096971 0.0090684622657919 4.029126213592233 9.24271844660194 1.3657020532080593 0.1972377481261837 2.230443861436908 1.484326001257553 1.1744026177454787 0.2553979780962895 0.1226742139485862 0.0756950383436983 0.1432798584585485 2.812625820330817e-05 4.8839176890034255e-06 +Autophagy of mitochondrion 11 33 2.600845443468054 0.0092994340092342 8.643203883495145 32.55582524271845 0.5912176019297528 0.507260115546458 3.9310041488944902 4.499114265424183 1.01585008111736 0.3556742421157408 0.0238915801945627 0.0533785743764077 0.0365585180593606 0.0101205340460747 0.000282388856727 +Cellular hormone metabolic process 5 19 2.598245518626221 0.0093701470304519 5.441747572815534 17.32766990291262 0.9908884218524354 0.2940959275691314 2.8170777488519256 1.7185203072340225 1.2515909253444888 0.3031653223897966 0.0007626845241698 0.0257915242502586 0.0014189260290535 0.001374788533299 0.0112872973833843 +Macromolecule depalmitoylation 1 5 2.594866038045677 0.0094627793150925 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0040983965897468 1.0 0.0056684159955205 0.0328731354880699 0.113339965404402 +Protein depalmitoylation 1 5 2.594866038045677 0.0094627793150925 1.3203883495145632 4.468446601941747 0.9114659728007516 0.274733419943775 1.0188856680336909 0.6320520706114182 1.1467191069327447 0.2583665413440971 0.0028240506634377 1.0 0.0039135152062846 0.0231366382468947 0.0823369674942117 +Glycosylation 18 47 2.5918043391470205 0.0095474053888786 13.33495145631068 45.42718446601942 0.831363055351092 0.4028474919440285 5.5712021107485015 7.578523489860055 1.3433056638769032 0.3649215649501745 0.7367784915570199 1.0 0.7934388322888715 0.0169952178401221 0.0267152456414294 +Neuronal action potential 1 5 2.5873276248658046 0.0096723576884862 1.2475728155339805 4.521844660194175 0.5642353900817267 0.463764525154269 1.1328582855694418 0.6169203935566157 0.8757196856996938 0.2995166866793592 0.0400526692576126 1.0 0.0471521402185075 0.1154193350298319 0.0214944247869924 +Regulation of macroautophagy 19 61 2.579213220662226 0.0099025643033912 12.53883495145631 54.54368932038835 0.6601926076755246 0.5184966676512008 5.17189441564166 7.149617002477752 0.982640144191414 0.3711017134042489 0.095779505577352 0.1399625708529587 0.0399865923514645 0.0052370120210683 8.459444388641232e-05 +Lysosomal lumen acidification 2 5 2.5618914854674784 0.0104103839781077 1.9077669902912624 4.094660194174757 1.0430284513288333 0.1731957374320673 1.0102570393282595 1.1504623937719378 1.495459416196642 0.2154807950267566 0.0034334205639732 0.0526645480715484 0.0047533286028597 0.0020064706347618 0.0141665154869097 +Ether biosynthetic process 4 5 2.560777786086718 0.0104438133163491 2.279126213592233 4.927184466019417 0.4312886834031472 0.4962399070037939 1.3837655160783582 0.5481999094578265 0.9002858560873801 0.3118323573140075 1.0 1.0 1.0 0.2175647207167039 0.010684483318579 +Cytochrome complex assembly 6 12 2.558428109322461 0.0105146558338442 5.339805825242719 11.616504854368932 1.5489281771301031 0.1834582376033618 2.45860248431673 2.439266047793512 1.3189185418401956 0.2620853228235733 0.2429761091428759 0.1541506060207377 0.0420348553288257 0.0012549484261259 0.0010690688695759 +Localization within membrane 46 191 2.555393968608612 0.0106067671016356 43.83252427184466 179.48543689320388 0.7329824809593914 0.5973922945503244 12.803162929787796 21.32668417309247 1.133148805830878 0.4087008058998355 0.3557531394244799 0.6916238028113749 0.4963041758068939 0.0250391297678622 0.0006505814102104 +Alcohol metabolic process 21 87 2.548076989426376 0.010831856310193 19.300970873786408 81.99029126213593 1.0392616248309592 0.3936245775900834 6.9548962308345 7.403089286448431 1.208378917036781 0.3759976884392474 0.0015284336925379 0.0825625608894291 0.0039375020442376 1.2407801327036288e-05 9.862496844284086e-06 +Glycoprotein biosynthetic process 21 55 2.5464601694248765 0.0108821629551241 16.72087378640777 51.87378640776699 1.042113998842759 0.381483262234126 6.756316800759528 8.908847583990125 1.5232206853916193 0.3819786061588057 1.0 1.0 1.0 0.0172419469934396 0.0232305870102045 +Atp transport 3 5 2.54493294361352 0.0109298725188125 3.4805825242718447 6.233009708737864 0.5838786306840471 0.3211615036091749 1.83337760624298 0.8807971179633459 1.3636108978108328 0.3170401972517012 1.0 1.0 1.0 0.0188064524051028 0.0005776438679051 +Cerebellar purkinje cell layer development 2 7 2.5439931212963818 0.0109593242773256 2.191747572815534 6.961165048543689 0.8392766864609098 0.2843914142715297 1.2383946131318218 1.2878998490964535 1.1730456034866912 0.2696789702944095 0.0092050279194046 1.0 0.0126574737404708 0.0087554356838108 0.0544656750173612 +Glycerophospholipid catabolic process 1 8 2.542223770883357 0.0110149628568048 2.216019417475728 7.563106796116505 0.8419758607208171 0.2558936783676348 1.405411068501889 1.391164232085279 1.2384126210044872 0.2497846504551273 0.1226742139485862 1.0 0.0100519320580488 0.0561137872346343 0.1818418904091173 +Calcium import into the mitochondrion 2 5 2.539550719871408 0.011099495018606 2.4563106796116503 6.04126213592233 0.8091317576129835 0.2214807715451704 1.7082137325011066 1.2010296388602073 1.3762222767333927 0.2421218388926935 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.2550529546148332 0.0182159139614431 +Negative regulation of leukocyte migration 0 6 2.5325364457316413 0.0113240596979289 1.5655339805825244 6.388349514563107 1.0839414642274992 0.2862432737648586 1.19995002173864 1.2770035444730965 0.9459956297737524 0.2624453160295969 0.1226742139485862 0.0756950383436983 0.1432798584585485 0.3247468214281712 0.5507460232908605 +Cellular lipid metabolic process 66 221 2.532519738503268 0.0113245993669999 55.06310679611651 205.83495145631068 0.2402431693065998 0.4937242414097398 20.280338607556292 23.717838556123585 1.6370289909336062 0.4061780961812439 7.50486711743899e-05 0.163614575963852 4.373291955217054e-05 9.114392056066745e-08 2.241501562239955e-07 +Ceramide transport 2 5 2.525749059172744 0.0115451914585738 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 0.100864684735291 1.0 0.1180585699575878 0.0382400085743442 0.0228394808772788 +Meiotic spindle assembly 2 5 2.524971196124062 0.0115707772551041 1.1592039800995024 3.154228855721393 0.2274719634324956 0.4964125333317712 0.9460719331376054 1.281748854779881 1.171249371551111 0.3199287699512845 1.0 1.0 1.0 1.0 0.0053637976870067 +Detection of biotic stimulus 1 5 2.5212964623167986 0.0116923296595627 1.4199029126213591 4.512135922330097 1.0591375818870654 0.2422781473049772 1.0196572764649048 1.0250968701423322 1.0664360760371396 0.2315508201016763 0.0040983965897468 0.0573151884822011 0.0056684159955205 0.0328731354880699 0.113339965404402 +Calcium ion export 2 5 2.516864820267668 0.0118404247904082 1.6844660194174756 4.128640776699029 0.405010289260511 0.458427433095341 1.1180129114659378 0.6077613681926137 1.011806942314794 0.3157947272796704 1.0 1.0 1.0 0.1577810442013011 0.0034775277607499 +Mitochondrial electron transport ubiquinol to cytochrome c 2 5 2.501401261495374 0.0123702931456026 1.5048543689320388 4.206310679611651 0.8658650693935839 0.2665349265497743 0.9514810775456936 0.7935779738409815 1.3072925004771625 0.2886561243868636 0.0709501192712976 1.0 0.0031504918831051 0.0010588751859522 0.0077568745967145 +Walking behavior 2 6 2.501142882760953 0.0123793222586883 1.5412621359223302 3.941747572815534 1.061808478348366 0.2641772565783438 0.940329605104622 0.948429900459882 1.1241511249150495 0.2684851276360596 0.1226742139485862 1.0 0.1432798584585485 0.0561137872346343 0.0401461367370898 +Regulation of mitochondrion organization 16 47 2.4900477377461905 0.0127725938290916 12.08980582524272 45.08252427184466 0.8217268052205459 0.4563186211764868 4.409741308614158 5.146210353910189 1.120993905462196 0.3778427085178187 0.228469810239162 0.1027744496234552 0.091109134162985 0.018133097015229 2.4324687349126644e-05 +Glycosaminoglycan catabolic process 1 5 2.4895014540014526 0.0127922395286552 2.6432038834951457 4.665048543689321 0.5167433573606753 0.1777854895826483 1.1305026922003756 0.6751064263980151 1.6910244329591049 0.2288538535307848 0.0860283086388496 0.0526645480715484 0.1008375048293403 0.027832231049335 0.0974859568290139 +Aminoglycan catabolic process 1 5 2.4895014540014526 0.0127922395286552 2.6893203883495147 4.728155339805825 0.5164809724591738 0.1764823388548578 1.1619294817897845 0.7656988020633148 1.69808407883546 0.2279588459746903 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.0328731354880699 0.113339965404402 +Tetrapyrrole metabolic process 5 21 2.4777308865790504 0.0132220830549965 5.652912621359223 19.283980582524272 1.0342508202848784 0.290677507336007 2.6828141040028877 2.549402305664568 1.2308389507353266 0.2976223887279709 0.005417471152029 0.0012757726476668 0.0085749794431607 0.0040251974639471 0.0050026695308212 +Regulation of nervous system process 2 14 2.4710926097626515 0.0134700930373157 2.6941747572815533 11.186893203883496 0.709685710886722 0.4267375683332639 1.6891041598029932 2.2483053074671338 0.9287991925104498 0.3050882814355576 0.3469532683251365 1.0 0.0890100643743446 0.1312000588255236 0.4687829092097882 +Mitochondrial cytochrome c oxidase assembly 1 5 2.467004005509972 0.0136248833464274 2.344660194174758 5.764563106796117 0.9954600272926416 0.2681565835601643 1.449018962088891 1.4364892997002987 1.2150903662861117 0.2820677765861404 1.0 1.0 0.191600110602388 0.0983610682747182 0.2914565107291916 +Respiratory chain complex iii assembly 3 6 2.436218142526476 0.0148417310352397 1.8470873786407769 5.160194174757281 1.360931378136811 0.1995688008303064 1.0650749835200868 1.2360161344522411 1.0120439004969468 0.2366879233397748 0.0633191306420368 0.0385773062479974 0.0743799864466655 0.0007187465088185 0.0003337445501144 +Cellular homeostasis 51 150 2.436092939478109 0.0148468693160301 35.03155339805825 140.69660194174756 0.4666088113804902 0.5685618966047314 11.62423291193178 14.777892439656425 1.1736922314243927 0.3887657095146841 0.6754554188015887 0.6203480442659333 0.5845772619373782 0.0517606125656443 0.0001877812722563 +Response to ph 2 5 2.4358753894739755 0.0148558012055106 1.7621359223300972 5.140776699029126 0.3480088533355521 0.3739523760080299 1.2528504590681426 1.153124661134805 1.2011912824917792 0.2945428652003891 0.1509425000049774 1.0 0.1758008751515455 0.0834574734746242 0.0708751155690715 +Cellular response to cadmium ion 0 5 2.4303076780420905 0.0150860101085577 0.9466019417475728 4.754854368932039 0.7346630274062432 0.4142129684279865 1.120013482406765 1.5170873755341794 0.9297582928234152 0.2900223727485326 0.1369226886862704 0.0847528009868792 0.1596960736798767 0.357118555081159 0.5935435236326052 +Negative regulation of gliogenesis 1 6 2.426011151828343 0.0152658011793538 1.3470873786407769 5.104368932038835 0.7908721225635217 0.3008340423028514 0.9967988871839628 1.1559387979758486 1.13650278668033 0.2567959459302846 0.1647372735136017 0.1026081339138497 0.018640880521655 0.0983610682747182 0.2914565107291916 +Glycerol ether metabolic process 5 6 2.4207266507372083 0.0154895198648381 2.7888349514563107 6.492718446601942 0.3049013983950943 0.5360040024219462 1.6971053602610944 0.9590880520585534 0.8600130036203345 0.3027961653474108 1.0 1.0 1.0 0.3247468214281712 0.0401461367370898 +Endomembrane system organization 47 174 2.419021617447761 0.0155623153355117 47.08980582524272 169.73058252427185 0.8987911429216844 0.5600148744834964 15.914797198368843 20.49740065572335 1.4161383035869868 0.4170367608227654 0.3871450046022617 0.5711826663660162 0.3151963186303143 0.1463576583198403 0.000609567222847 +Lipid homeostasis 10 27 2.416334218402225 0.0156776636018853 7.665048543689321 25.939320388349515 0.8425417577103904 0.3366972259521467 2.992619034719237 3.7336969269092393 1.1648658675422845 0.295769208633365 0.1464578257144481 0.3361355940595682 0.1897338295109766 0.0152064912316461 0.0022128693915906 +Fatty acid transmembrane transport 2 7 2.414173842683716 0.0157709356993502 2.3519417475728157 6.720873786407767 1.487456141723218 0.1763040127694548 1.5547987465385102 1.1092073674791965 0.7935702169981724 0.2103298472796338 0.0934764824591146 1.0 0.1094892401774078 0.00262770885776 0.0182159139614431 +Regulation of blood pressure 7 19 2.413516254143361 0.0157994231651081 5.762135922330097 17.737864077669904 1.3077123393993415 0.1882731913471478 2.2751770017499977 2.3871059987956724 1.372929386780725 0.2480453688154592 0.0116356079020295 0.0327224420542492 0.0181443698350236 0.0129296559640097 0.0067400711985061 +Modulation of excitatory postsynaptic potential 1 5 2.413345449707096 0.0158068300034162 0.8616504854368932 4.184466019417476 0.8716049128546732 0.3904030169730884 0.8964791942932838 0.8154761884284932 0.955782621454512 0.3079648786148587 1.0 1.0 0.1515272625734178 0.062605312422627 0.1998160014011807 +Intermembrane lipid transfer 1 8 2.394510880714297 0.0166425496498325 1.966019417475728 6.618932038834951 0.4006158968389467 0.3501200832710581 1.370213887212628 1.5743486325272755 1.2182069511780798 0.2776659407244052 0.0261335387625208 0.0100088432903632 0.0354914601129098 0.1724444479617574 0.450369534817547 +Kidney morphogenesis 1 5 2.3935171982194725 0.0166876989583877 1.1504854368932038 6.298543689320389 0.5679444269039395 0.4923204881150714 1.3389877198337503 1.4880422453073698 0.7785302422673186 0.2834148378199908 0.3469532683251365 1.0 0.3955810682553247 0.3601862036851755 0.7282060140583244 +Leukocyte differentiation 25 71 2.391332542907578 0.0167873400403621 13.259708737864075 62.82281553398058 0.2230074329146526 0.6311707774623282 5.891661699815195 7.755058720737631 0.8147397072079771 0.3290680435049292 0.643944990984077 0.7355299784186087 0.7316052790577359 0.7798466845039014 0.0370144977496041 +Intracellular lipid transport 3 14 2.390628172871512 0.0168195771752819 3.2475728155339807 12.529126213592232 1.0333463606041455 0.2805251274605093 1.854375285913986 2.478377603832177 1.0146678848168829 0.2521579143644115 0.2367426782920286 1.0 0.2732850813359189 0.007920049564759 0.0747991773170861 +Endoplasmic reticulum to golgi vesicle mediated transport 24 65 2.387656152230162 0.0169561977552923 17.32766990291262 65.39077669902913 0.808881464821498 0.4942452999677598 7.539018980743236 6.620812461410292 1.284359804176963 0.3933269611423161 0.0671474226148655 0.433640456963297 0.0987427785556486 0.0215851652574667 0.0001366068341766 +Negative regulation of amyloid precursor protein catabolic process 2 7 2.386564850641137 0.0170066076252635 2.645631067961165 8.78883495145631 0.7296788020743029 0.3749260712143212 1.4314957008524525 1.1001198531094605 1.057374600950545 0.3066940057573566 0.1298272630870375 0.0802348466038066 0.1515272625734178 0.062605312422627 0.0470360579614364 +Regulation of lysosomal lumen ph 2 6 2.379832256332894 0.0173205205524125 2.3567961165048543 5.58252427184466 1.1719038900849827 0.159040563248536 1.2351555175791742 1.4280428037740598 1.4707016211600112 0.2132438131163355 0.0064177808396821 0.0711332726649859 0.0088504827764808 0.0051503840765812 0.0338099842169397 +Intracellular transport 128 594 2.377933193878051 0.0174099798222528 120.90291262135922 544.3956310679612 0.5500812282996078 0.6924011803517542 31.43517433849213 53.582766758854405 1.193070641867047 0.396756529943003 0.0021819329839523 0.0812340508433709 0.0151744863157423 1.503350094101974e-05 5.396622462967162e-10 +Nucleotide transport 6 10 2.3729956245865504 0.0176444729371501 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 0.191665926491972 0.1201219647894398 0.2223047329091382 0.000347389598862 0.0001833997890783 +Glycoside catabolic process 3 6 2.372894833057968 0.0176492883820036 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 0.0017758793795144 1.0 0.002465796513642 0.0148625463558957 0.0003337445501144 +Pigment metabolic process 5 26 2.372295409759999 0.0176779504029527 6.730582524271845 27.429611650485437 0.7330558837492486 0.3938325994367372 3.1680652652278396 2.973572406869117 1.1788232115476622 0.3357800616079686 0.0100666740230864 0.0024333620388206 0.0157478410048603 0.0438041643494559 0.0167583931949217 +Endoplasmic reticulum membrane organization 5 8 2.370783833632323 0.0177504091343403 3.5679611650485437 8.12621359223301 0.656874598832497 0.271683145803182 1.813579499342004 1.2879547393790816 1.532817064292788 0.2945772195616556 1.0 1.0 1.0 0.003355333516566 0.0002504856541451 +Ceramide biosynthetic process 4 10 2.3623382456925457 0.0181600644815962 4.033980582524272 10.24757281553398 1.048715387316577 0.2344614502118888 2.237979905601341 2.0281678881596505 1.4071730245015133 0.2685344998940062 0.2491592407033175 1.0 0.0443091130960601 0.001435579094649 0.0063226090272968 +Signal peptide processing 2 5 2.362306625586971 0.018161613649845 2.0898058252427183 5.155339805825243 0.788498872885968 0.2357910477072221 1.2938213743418876 0.7208043181852656 1.3841109341751536 0.2490116896927748 0.0860283086388496 0.0526645480715484 0.1008375048293403 0.027832231049335 0.0141665154869097 +Positive regulation of macroautophagy 9 24 2.357311374643922 0.0184078045046143 5.058252427184466 20.34223300970874 0.7197293510270528 0.4154159089925248 2.5734840677494253 3.836065802213299 1.0387053871978371 0.3265560923975395 0.0856229888655945 0.0348230103466341 0.1132051672598368 0.0148252690690975 0.0005781925850387 +Cellular ion homeostasis 35 87 2.3560293307791795 0.0184714591455885 24.48543689320388 87.34708737864078 0.921352068115914 0.4223079442129951 9.212290310790763 8.933596252465952 1.5207794649628892 0.4002972861975121 0.3842847460551211 0.3887258576445169 0.2676537229472664 0.1270039158258352 0.0017825234792375 +Membrane lipid catabolic process 4 13 2.355146858339496 0.0185153865652096 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 0.0005365920794546 1.0 0.0008717411361388 9.22092773458021e-05 0.0002808101441202 +Nadh dehydrogenase complex assembly 10 28 2.35465443233911 0.0185399380998936 9.266990291262136 26.96359223300971 1.1245271541492263 0.3013677937017552 4.122702675359976 4.029157649894909 1.4460543016521823 0.3224564676521605 0.0784025564630051 0.0316917589218704 0.0173242512102645 0.0024554723849656 0.0003775126449021 +Regulation of mitochondrial fusion 4 5 2.353715582284132 0.0185868265355448 1.5242718446601942 4.766990291262136 0.7253550907037913 0.367601169377127 1.0824698493002796 0.7815081697098348 1.0008486659137603 0.2877626014609443 1.0 1.0 1.0 0.0231366382468947 0.010684483318579 +O glycan processing 2 5 2.3489092881648728 0.0188284932430151 1.8762135922330097 5.029126213592233 0.779006640385936 0.3319918611732407 1.1540209287066336 1.1758600296433448 1.0243123329907684 0.2736840802111854 1.0 1.0 1.0 0.1139407547181512 0.1093101132411038 +Positive regulation of chemokine production 2 7 2.3482538904213413 0.0188616595092057 1.703883495145631 7.002427184466019 1.1308330497685224 0.261365768238967 1.2206493839204828 0.948936007151574 0.9251734036107908 0.2478284645013121 0.1715513885376269 0.1070183553885475 0.1993869387044997 0.1060727287920157 0.09905667817091 +Lipoprotein metabolic process 6 21 2.346645337222946 0.0189432766834369 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 0.0050146181270217 0.3426841548479852 0.0089732445190698 0.0551022953292233 0.1200224502842224 +Ph reduction 4 13 2.342586547821023 0.0191505917727596 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 0.0215796251678188 0.1287528218161406 0.0023694947377154 0.0004989114687539 0.010448798153629 +Regeneration 6 34 2.335830033397172 0.0195001016625311 6.191747572815534 31.563106796116504 0.5380382799076718 0.5740012495882397 3.277553825936591 3.489707203654107 0.7812061797301654 0.3285807753592402 0.0539615299706925 0.093603257631803 0.0183313093591291 0.1112177727483601 0.0700280573838956 +Negative regulation of regulated secretory pathway 0 5 2.3315463980321915 0.0197245664878895 0.9781553398058253 4.398058252427185 0.7700890595439712 0.3703070501759239 1.164611062683957 0.8514956096808038 0.9880129676694246 0.2942343620509365 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.2550529546148332 0.4511907478135378 +Lipoprotein localization 3 8 2.3278136672314003 0.0199220000342155 1.7451456310679612 4.762135922330097 1.33870340128666 0.2150435313503844 1.1193794779630346 1.3835803073772095 0.999398972942542 0.2555578059866495 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.0328731354880699 0.0020183200628615 +Protein o linked mannosylation 3 5 2.323845814934628 0.0201337592367054 1.2087378640776698 3.487864077669903 0.5566012718394135 0.422693141596952 0.9579110358712762 0.7486870715056347 1.094367649259236 0.3075703139437587 1.0 1.0 1.0 0.2731207001200411 0.0228394808772788 +Protein mannosylation 3 5 2.323845814934628 0.0201337592367054 1.230582524271845 3.5776699029126213 0.5262069874103198 0.4175627359044286 0.9667966576123064 0.8397216412152502 1.108389625854248 0.3033484504285141 1.0 1.0 1.0 0.3411306657380243 0.0470360579614364 +Proton transmembrane transport 15 40 2.323680199726386 0.0201426404525779 14.28640776699029 43.01699029126213 0.7821394801431882 0.3918912894345224 6.076814900000799 3.1076483585332 1.5710697941383835 0.3739424994204808 0.1780068489281796 0.3713777336871285 0.061711249787699 0.0004398170742491 0.0001705988853611 +Sterol transport 3 26 2.322882158439382 0.0201854838428188 5.516990291262136 23.23058252427185 0.3564989162781894 0.4550431454343515 2.7566693478017315 3.339632072416373 1.1016145306573315 0.3225081354886266 0.0178361082707862 0.0437266531990119 0.0275216398495969 0.0824194625829831 0.2364098572110782 +Positive regulation of mitochondrion organization 10 23 2.320682069734674 0.0203040091379818 6.235436893203883 22.393203883495147 0.6669540243221574 0.4355223453199826 2.7589935116766484 2.962672702300372 1.01251720769805 0.3295170825531805 0.3522966120458038 0.2298835505782255 0.0919415891551245 0.008923404115777 3.906862786026704e-05 +Positive regulation of nervous system process 0 5 2.3099073753682524 0.0208932826624603 1.058252427184466 3.621359223300971 0.3617098287243019 0.4791062052878357 1.0642034508608802 0.9962697889215768 0.9995475352300992 0.3024239413218048 0.1081933924999157 1.0 0.1265462710440741 0.290751966651369 0.5034522087350044 +Porphyrin containing compound metabolic process 4 17 2.3026661994222506 0.0212976313550132 4.91747572815534 16.531553398058254 1.0269348271542438 0.279733852070357 2.276512713100022 2.089380108414912 1.2578863722796805 0.2914421038569487 0.0028215617056553 0.0006503204391585 0.0045096021611559 0.0097601039903573 0.0063226090272968 +Iron ion transport 6 9 2.301925824121902 0.0213393556053631 2.8762135922330097 9.3252427184466 0.6984692822717036 0.3339124009240178 1.7603279794274296 1.4434464182805606 1.1549328537786283 0.2828654848729625 1.0 1.0 1.0 0.1899587232036964 0.0747991773170861 +Amyloid precursor protein catabolic process 4 15 2.298057985814265 0.0215584890746822 4.62621359223301 16.47087378640777 1.203006467000838 0.2754962460876 2.1329801006381106 2.1803683249886516 0.947433834000198 0.2709877848980267 0.0496923416317891 0.0195557545343205 0.0666692325567911 0.0213813720021448 0.0614446561434308 +Aminoglycan metabolic process 4 15 2.295732716782346 0.0216911685828533 6.650485436893204 15.218446601941748 0.5538240398360251 0.1973407167351751 2.4739761552565955 2.4752855115427597 1.8355272359461776 0.2521795038965069 0.3984836434715033 0.2633971592089756 0.4515227909961177 0.0168986737095617 0.1837162306077457 +Response to progesterone 1 5 2.2957077400313146 0.0216925976021427 1.354368932038835 4.567961165048544 0.3842719312454053 0.4842439730306144 1.1723577355080894 1.195762225303476 0.9635234972248428 0.3017168949830429 0.1226742139485862 0.0756950383436983 0.1432798584585485 0.3247468214281712 0.1818418904091173 +Negative regulation of nitric oxide metabolic process 1 5 2.2945936840602705 0.0217564205707501 1.2912621359223302 4.016990291262136 0.5630789128357685 0.3784379265680423 0.9204375063682588 0.8825177299040856 1.0918982949647362 0.2851076124121109 0.0709501192712976 0.0432957136582515 0.0832836732680532 0.1981219124770219 0.0680064706612652 +Response to muscle activity 2 5 2.292419715245725 0.0218814354442777 1.1820388349514563 4.364077669902913 0.5239254658848286 0.45987221631934 0.9696199427834098 0.759068715173887 0.9441019188718152 0.3060195977413827 1.0 1.0 1.0 0.1577810442013011 0.0034775277607499 +Transferrin transport 2 5 2.291140583155728 0.0219552841057126 1.3567961165048543 4.084951456310679 0.0411177659246124 0.5131074055879287 1.0457391250473616 0.6424065400445841 1.0114807272198103 0.3190626379787961 1.0 1.0 1.0 0.1781979724676324 0.0546176715347421 +Mammary gland epithelial cell proliferation 2 6 2.287928616402216 0.0221416785046779 1.5 5.25 0.3625881460002983 0.5128071511243121 1.207782208876116 1.3467418432027014 0.9074645670527792 0.3044724408899644 1.0 1.0 1.0 0.4452488918515388 0.1093101132411038 +Intracellular protein transport 66 343 2.285635625845512 0.0222755841622059 72.23543689320388 320.84466019417476 0.4871189760263694 0.7214714639205947 20.45645165050656 29.914524602040487 1.0524664106682724 0.3751399671828122 0.051110551286917 0.1172475525147601 0.1222116110201987 0.0005527517225015 1.0319434635858193e-08 +Peptidyl glutamic acid modification 2 5 2.283490924005364 0.0224014668717604 1.2766990291262137 4.783980582524272 0.5726285862666396 0.4410327304183206 1.015004317126516 0.8299231919143666 0.9676219991614484 0.3116400575480735 1.0 1.0 1.0 0.0439142352380576 0.1467539296032722 +Lysosomal protein catabolic process 4 8 2.280683153801794 0.0225672027337908 2.6941747572815533 6.587378640776699 0.838918419522322 0.2080383809566978 1.5899151374262637 1.8707342212441815 1.5239608036504366 0.2420459791980847 0.0092050279194046 0.0847528009868792 0.0126574737404708 0.0007869115437374 0.0013613651941044 +Protein catabolic process in the vacuole 4 8 2.280683153801794 0.0225672027337908 2.70873786407767 6.618932038834951 0.8383076008345888 0.2101105309103242 1.6017652153393662 1.88837291272598 1.5176899437744062 0.242508547144668 0.0113114865314974 0.0937235599037543 0.0155240337321844 0.0011993766429203 0.0022722304352638 +Respiratory chain complex iv assembly 2 6 2.2795644689340246 0.0226335322916582 2.7475728155339807 6.451456310679611 1.036831430168084 0.2562354664331627 1.605321530277248 1.669274831081891 1.262804896468415 0.2848709091577191 1.0 1.0 0.2147385524083838 0.1219531221716571 0.1199524552735497 +Alcohol biosynthetic process 14 37 2.263103693583385 0.0236292979272501 9.344660194174756 36.09466019417476 1.0726679306851277 0.3539682718575088 3.792896481514287 3.1078151772256564 1.1587776417647702 0.3419459456532639 0.0348097020403367 0.3523884632837075 0.0526082110144703 0.0002679145729267 1.9907067560788416e-05 +Lipopolysaccharide mediated signaling pathway 2 9 2.2594973169341435 0.0238524670178583 1.8737864077669903 8.281553398058252 0.8878970764300863 0.35030444949346 1.2399468486141116 1.678924041304143 0.8123823005829252 0.2523157110268533 0.0245754818920448 1.0 0.0334071197556988 0.1637924032376012 0.1781060735503897 +Peptidyl serine modification 24 81 2.257801315632181 0.0239580491713504 15.684466019417476 64.47330097087378 -0.0255197168682743 0.675603190918526 7.744553454525985 10.538959887548597 0.7555498450856009 0.3087691688728917 0.8506538349481674 0.681327455599611 0.6527731189529361 0.3235988352127636 0.0963942406456812 +Outer mitochondrial membrane organization 2 5 2.257371506501629 0.02398487061503 1.4296116504854368 4.956310679611651 1.1531610290328034 0.2630141305877053 0.9963023114429655 0.2044029443827893 0.89744850896642 0.2676384061848394 0.0400526692576126 0.0242848323540905 0.0471521402185075 0.1154193350298319 0.0010694525645264 +Mitochondrion distribution 2 5 2.256852528749552 0.02401729116171 0.883495145631068 4.531553398058253 0.9534471314234194 0.3596945395533431 0.988290382956546 0.6434694450867872 0.8683890493550602 0.2867680655791957 0.100864684735291 1.0 0.1180585699575878 0.2731207001200411 0.4779737602264646 +Regulation of leukocyte degranulation 1 6 2.2539886839309986 0.0241968798787877 1.6699029126213591 6.470873786407767 0.5853711877145334 0.3457823611194687 1.4305158925119918 1.701406104268744 1.0992219708926214 0.2597166324139169 0.1647372735136017 0.1026081339138497 0.191600110602388 0.4172977923286156 0.2914565107291916 +Aminoglycan biosynthetic process 3 8 2.248515420024137 0.0245433429492347 3.0800970873786406 8.300970873786408 0.6387272076133388 0.2830924102482349 1.486473637192798 1.7113836533227735 1.3163721030030058 0.2655273000426038 1.0 1.0 1.0 0.0808776862517318 0.3363841302805421 +Negative regulation of autophagy 3 24 2.2453662540693338 0.0247446299347322 5.063106796116505 24.313106796116504 0.449887145270975 0.5377284095479077 2.9855473971181983 2.929018368027943 0.8516059018543028 0.3205218740462018 0.1031978917613202 0.0425713267043903 0.1355867800667393 0.0789974698724344 0.2273380233334186 +Regulation of water loss via skin 0 5 2.2405616649942783 0.0250544822123184 1.3980582524271843 4.95873786407767 0.4829857617931532 0.4190090745011622 1.132827083225922 0.8422959602674207 1.0405700816787415 0.2964107522750627 0.1154630790463651 1.0 0.1349531130589082 0.307957256786686 0.5276895149825147 +Acute inflammatory response 1 5 2.2373556105628567 0.0252631072966471 1.4466019417475728 4.689320388349515 0.9285034691739726 0.2315648833934721 0.949993922717463 0.5957637867345709 1.213201626775504 0.2269795845272838 0.0160900301160464 0.0060718409625537 0.0219975904219434 0.1139407547181512 0.3280048671308403 +Glycosphingolipid metabolic process 5 10 2.2336718188412985 0.0255046745662022 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 0.0293662469729552 0.1499686155438198 0.0398064357050217 0.007920049564759 0.0046837779345005 +Liposaccharide metabolic process 7 18 2.229911000745551 0.0257533519319346 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 0.080787090338714 0.2486824788491954 0.107004894081217 0.0026843919056765 0.0067400711985061 +Vacuolar acidification 4 10 2.22760109946708 0.0259071272909756 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 0.0092050279194046 0.0847528009868792 0.0006327439593496 5.302129833761715e-05 0.0013613651941044 +Mucopolysaccharide metabolic process 4 8 2.2263067123978764 0.0259936441788684 3.400485436893204 8.912621359223301 0.5894446998893683 0.2689339883290864 1.6227448151896249 1.7256308603927724 1.433353391777711 0.275728271795533 0.3083107652154563 0.1988423464133734 0.3530974878629287 0.0949405615621671 0.3768947236315802 +Cytosolic calcium ion transport 10 26 2.225626819952328 0.0260391881983235 6.567961165048544 23.944174757281555 0.4634706877593821 0.4616211122842976 3.323605294530572 2.8902732844456565 1.0331628024603872 0.3216839736311487 0.502251049808566 0.3426841548479852 0.5614825641059915 0.339549447449659 0.0026801846148119 +Mononuclear cell differentiation 17 50 2.224261774570256 0.0261308369492179 9.111650485436892 45.05825242718446 0.1366745299088765 0.6662710348554396 5.006031332610922 5.303553018108913 0.7143498771214317 0.2995144284800984 0.4895220999568962 0.631365625598012 0.5790998686136157 0.8696414366649964 0.0365459111767632 +Glycoprotein metabolic process 24 62 2.2173749546778185 0.0265974797184262 18.59223300970874 59.577669902912625 0.8707431654759812 0.409720724299967 7.543964208858723 9.989377193127202 1.488085349392555 0.3835029669336279 1.0 1.0 1.0 0.0483178302995877 0.0857708430007882 +Transepithelial transport 3 5 2.214552656876737 0.0267907846321671 1.6553398058252426 4.774271844660194 0.6732735902855568 0.3468688130957016 1.1752486335033188 1.0771313051019258 1.1029852758785914 0.2818815040837556 1.0 1.0 1.0 1.0 0.0470360579614364 +T cell differentiation 10 27 2.2115529853618203 0.0269975669800788 5.021844660194175 25.37378640776699 0.4350228719786409 0.5180951440553598 2.967789621588004 3.0760730597535333 0.9025381406717272 0.3196787714458526 0.2586407265060255 0.4502911936035841 0.324578641637734 0.5651059189685674 0.0337848883208686 +Tetrahydrofolate biosynthetic process 1 5 2.2113877475911696 0.0270089975750706 1.7936893203883495 4.983009708737864 0.1605580267226933 0.4510199931505445 1.7386689978430927 0.1292347525434382 1.0823232133771 0.2967084841927126 0.0478709038219733 1.0 0.0563150378970086 0.0082211090226218 0.0312108672695238 +Folic acid containing compound biosynthetic process 1 5 2.2113877475911696 0.0270089975750706 2.0364077669902914 5.548543689320389 0.1185786473734218 0.460967837187085 1.9007241105446349 0.5306826667147115 1.0747056928647158 0.3004314837246528 0.0633191306420368 1.0 0.0743799864466655 0.0148625463558957 0.0546176715347421 +Regulation of cellular ph 4 21 2.209202904974904 0.0271605309324181 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.0601982145921569 0.2145132052110039 0.0115248505447769 0.006410021202963 0.03080273588529 +Regulation of ph 4 21 2.209202904974904 0.0271605309324181 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.0668350320040178 0.2260688267312995 0.0135419734012732 0.0082403851981354 0.0397377338982377 +Regulation of oxidoreductase activity 8 17 2.2063815558423814 0.0273572953437106 4.745145631067961 16.524271844660195 0.8435277245089666 0.3527293456818395 2.542951562396442 1.641953963820047 1.0033906386071183 0.2899852749738094 0.0713888723716441 1.0 0.0949012099695084 0.1423397245441582 0.0010808437399693 +Protein transmembrane transport 5 25 2.202487562423165 0.0276308867345445 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 6.685691679625825e-05 0.027703186905031 0.0001474440444245 0.0016834035897202 0.0038524008603266 +Positive regulation of autophagy 11 34 2.1989012682558124 0.0278849434255237 7.036407766990291 30.483009708737864 0.6693528554580194 0.4628135853102879 3.235293043364778 5.784747493453153 0.9361869896860724 0.333658419297932 0.0630484281661602 0.1043267655807623 0.0929934383816013 0.0545097952893404 0.0082613470370876 +Lipoprotein catabolic process 2 6 2.196095747894361 0.0280850908804362 1.529126213592233 5.211165048543689 0.7074087979902727 0.279320898549559 1.1111204061152251 0.9407555329409328 1.2623530327786678 0.2599848817817885 0.0064177808396821 1.0 0.0088504827764808 0.0498779046475234 0.0338099842169397 +Establishment of protein localization to organelle 43 186 2.1819228404263584 0.0291152278307951 40.4247572815534 180.123786407767 0.6176411706537287 0.628535284461401 14.116769229706104 14.40373863390995 1.0281809729691214 0.3983757503188239 0.0083801307458013 0.0298849699939403 0.0213576408438396 0.0004199967720517 1.0851656685463628e-05 +Determination of adult lifespan 3 7 2.1818016675527474 0.0291241734633944 1.4684466019417477 6.878640776699029 0.9172678211727472 0.3356532972350567 1.327993783820954 0.8617154358126836 0.9778379941999832 0.290947936133699 0.0055914837945719 1.0 0.0077184558590264 0.0439142352380576 0.0037759888499611 +Macroautophagy 34 113 2.1799304279238343 0.0292626190303038 25.570388349514563 102.68203883495146 0.4734815024857951 0.6429834425349866 8.949285204664525 14.162660044372751 0.8554944786686205 0.3590213706304501 0.3664852753928785 0.3746413358700076 0.2507170766518014 0.1103501291422771 0.0052026631612309 +Chloride transmembrane transport 3 6 2.177048420421249 0.0294769548932871 1.9271844660194175 5.497572815533981 1.0121969151812915 0.2503571453769561 1.6864793094247907 1.5080669592016671 1.1003731395705292 0.2453144412674818 1.0 1.0 1.0 0.3411306657380243 0.0470360579614364 +Monovalent inorganic cation homeostasis 10 28 2.174921853404184 0.0296359729758366 9.014563106796116 27.87378640776699 1.1567920478867002 0.2845186374336156 4.051822262152646 3.607380814764068 1.4117439861533438 0.3149022278800241 0.1189734911484879 0.3024216363859021 0.033011066423499 0.0317341418138132 0.0251503768819699 +Cerebellar cortex development 2 12 2.1738368562087507 0.0297173895382714 3.2014563106796117 12.951456310679612 0.4913835354280507 0.4216383686135529 1.7737836843231067 1.855867843348426 1.0191189701346923 0.2901119129344551 0.0327496360061982 1.0 0.0443091130960601 0.0520565373494006 0.2421884168027767 +Excretion 1 5 2.1709366042573364 0.0299359648847039 1.269417475728155 5.201456310679611 0.6776908500633984 0.3886507914896875 1.1481249595760017 0.8622041158633096 0.9714806682442636 0.2826040335002768 0.1439609493286736 0.0892490045576324 0.1677870330809631 0.3727200206787977 0.236286730772413 +Regulation of dna primase activity 2 5 2.163545697089787 0.0304992329891877 1.5121359223300972 3.800970873786408 0.3367565838445433 0.5408150482429197 1.082673919736029 0.796959652976267 0.9529413940968616 0.3253082528692553 0.0400526692576126 0.0242848323540905 0.0471521402185075 0.1154193350298319 0.0214944247869924 +Purine containing compound transmembrane transport 4 7 2.1629472983693505 0.0305452333060896 3.6432038834951457 8.228155339805825 0.8480777288434221 0.3004167480224937 2.0847056152178514 1.431742605530374 1.2278207398320582 0.2967021731271802 0.1081933924999157 0.066549445548378 0.1265462710440741 0.0041946485896371 0.00037411273114 +Calcium ion import 6 13 2.15986433169369 0.0307831736940589 4.516990291262136 12.686893203883496 1.0417029373125424 0.2391249176108038 2.3196506830054986 1.9148178088324157 1.3383409214307818 0.27915846054651 0.0362780952267646 0.1665759675679584 0.048990890514732 0.2256009180273313 0.0324377486516598 +Neuron projection regeneration 2 11 2.159147985152522 0.030838687922015 2.3058252427184467 9.79611650485437 0.887202443720293 0.3987106095324453 1.3505356896696743 1.5461145996848544 0.8042022398095918 0.2932545495700766 0.0327496360061982 0.1583124314184509 0.0045096021611559 0.0520565373494006 0.2421884168027767 +Negative regulation of blood pressure 2 5 2.1539225575277547 0.0312462456261952 1.3883495145631068 4.186893203883495 0.7622294394612346 0.2478679651965233 0.7661910546387906 0.5883356962714492 1.358951451673839 0.2503899088710304 0.0028240506634377 0.0479914252810258 0.0039135152062846 0.0231366382468947 0.010684483318579 +Cellular macromolecule localization 133 587 2.153832156125944 0.0312533369680902 116.74029126213593 544.3228155339806 0.3819130491508938 0.7577794226812853 28.882302639166586 53.383983306101904 0.8794377571334007 0.3523979567946485 0.2688465801491582 0.3134954779514945 0.5020045903917087 0.0036255056405351 2.0417937342786426e-07 +Organic hydroxy compound metabolic process 22 119 2.152969180429295 0.0313211007641129 24.233009708737864 110.8883495145631 0.5334558429683288 0.4627633417898757 8.017219191403747 10.01417249072314 1.2419084217888356 0.3713800795527268 0.0087236425707 0.1658369531762066 0.0204190284700926 0.0002107551803872 0.0003549686915583 +Diol biosynthetic process 2 7 2.15284571745266 0.031330805798255 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.0048180551758565 1.0 0.0066572828402184 0.003355333516566 0.0028040242445346 +Diol metabolic process 2 7 2.15284571745266 0.031330805798255 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.0072960555134274 1.0 0.0100519320580488 0.0062267265321947 0.0063533232968262 +Organic hydroxy compound biosynthetic process 13 55 2.146639387587065 0.0318220016514863 12.42233009708738 52.37135922330097 0.7934054609743442 0.424605725297311 4.713262264354627 5.1877801804871915 1.1130427360157376 0.3580104692277669 0.0909663505918914 0.4769824301569347 0.1316707557608008 0.0045169289476005 0.0002027795715202 +Inorganic anion transmembrane transport 5 9 2.1395292011241147 0.0323928335779846 3.4101941747572817 8.983009708737864 1.1245392058053427 0.2357455210082705 2.3748669786284156 1.7214248641786654 1.1968417731555627 0.2697184972505711 0.2112978307962688 1.0 0.2445730022705269 0.1552222190730896 0.0504521665366165 +Amide transport 11 41 2.136371785778635 0.0326491218869431 9.512135922330096 37.99757281553398 0.8625203235532012 0.4243895840783888 3.9342099663331425 4.541875701235624 0.963016155404646 0.3369249994514658 0.3069800654544993 1.0 0.3803883597337516 0.0488236457953868 0.070832822352764 +Transmission of nerve impulse 2 7 2.135139095433632 0.0327496500134347 1.6771844660194175 6.643203883495145 0.3619553328898606 0.5471795517105698 1.4330237685789071 0.8339736597924642 0.7570915834009635 0.2720943657720215 0.1226742139485862 1.0 0.1432798584585485 0.3247468214281712 0.1818418904091173 +Synaptic transmission gabaergic 0 5 2.134916335415175 0.0327678447440127 1.3422330097087378 4.519417475728155 0.2347132009622901 0.5263821702803212 0.9813122104836663 1.053017693397039 0.9634597836833804 0.3045939104536951 1.0 1.0 1.0 1.0 1.0 +Purine nucleotide transport 4 8 2.1324583495982345 0.0329691849861324 4.970873786407767 10.817961165048544 0.961055494000064 0.2880106547862709 2.8308505383502496 1.988649275322177 1.3314072021441097 0.3042395363852717 0.1509425000049774 0.0937235599037543 0.1758008751515455 0.01180448121602 0.0022722304352638 +Regulation of nitric oxide synthase activity 3 7 2.124731252780164 0.0336090440987042 1.8980582524271843 6.400485436893204 0.8861714382596724 0.3064882013314778 1.014121704509923 0.9815283096291466 0.998778670456744 0.2492245557560045 0.0102339970863349 1.0 0.014058804472369 0.0762921742488627 0.0120515986398723 +Cellular monovalent inorganic cation homeostasis 4 25 2.122070485839467 0.0338318194210176 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.0880733344897457 0.2597451867723493 0.0207328276809773 0.0158393462317253 0.0281223334511535 +Organelle disassembly 13 52 2.116213136878543 0.0343266844286886 11.983009708737864 49.20388349514563 0.433561938027762 0.6160490735942882 4.954374615918461 6.142102393453674 0.8047024382669711 0.3415228222424311 0.0514908809094408 0.090603000234403 0.0766374872717975 0.0388423821354079 0.0004508403759836 +Multicellular organism aging 3 10 2.109151425692694 0.0349315131493488 2.1674757281553396 10.37864077669903 0.7123407673681669 0.4042486598886041 1.8218230592238136 1.366140512569931 0.923721768654342 0.2985518072202843 0.0124366578275625 1.0 0.0170518298819148 0.090818300458346 0.0172333771485565 +Sterol homeostasis 2 12 2.097793841731355 0.035923360766175 3.2597087378640777 11.594660194174756 0.7425754872590924 0.2773502445350785 1.6018884221780605 1.6170423171351411 1.3033948892752858 0.2615762483252933 0.0380950107843236 0.1706778675257841 0.0513963234576887 0.063688713570506 0.2822516950414785 +V d j recombination 3 8 2.0940002899986885 0.0362599544167876 2.9563106796116503 6.478155339805825 -0.2388966821444213 0.4835040509480232 1.730097359789895 1.245188212523476 0.9853013900358896 0.3049031121528418 0.1509425000049774 0.0937235599037543 0.1758008751515455 0.3879443652654283 0.0144964406909979 +Maintenance of location 17 74 2.093892446775742 0.0362695622765163 14.529126213592232 67.10194174757281 0.2761251361558006 0.5437230382448518 5.781761264023897 6.826866977938762 1.0069098531292424 0.349986956897805 0.0229421086682728 0.2552254179082389 0.0426118271714143 0.0229801348291327 0.0038654968924716 +Peptide catabolic process 5 11 2.0934446489616554 0.0363094802427526 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 1.0 1.0 1.0 0.0009779431698101 0.0002049367226 +Maintenance of protein location in cell 6 25 2.0932861937928378 0.0363236143518908 4.963592233009709 20.74757281553398 0.5138976626555444 0.4828559702191822 2.90064182866346 2.9061984196552437 0.947299732036647 0.3164077327541715 0.0073202198372533 0.0239365913087713 0.0115248505447769 0.006410021202963 0.0091015487948519 +Ribonucleoside metabolic process 2 7 2.0920874484964163 0.0364306937380882 2.1189320388349513 8.12621359223301 1.1914157696469383 0.2635896161542528 1.2648845164842024 0.7462477223524518 0.9827848183963048 0.2624193088278075 0.1783105780413945 1.0 0.2070995190727305 0.1139407547181512 0.1093101132411038 +Purine ribonucleoside metabolic process 2 7 2.0920874484964163 0.0364306937380882 2.063106796116505 7.834951456310679 1.2047777662844132 0.2574288772305114 1.199068432200366 0.6246876870736083 0.9870596763535292 0.2611531847589775 0.1298272630870375 1.0 0.1515272625734178 0.062605312422627 0.0470360579614364 +Mitochondrial calcium ion transmembrane transport 4 8 2.090884025441646 0.0365384614265564 3.4684466019417477 9.04126213592233 0.7792467211325117 0.2463779000555085 2.196969341156949 1.2010296388602075 1.3738174116662032 0.263849842646199 0.1226742139485862 0.0756950383436983 0.1432798584585485 0.0561137872346343 0.0063533232968262 +Glial cell proliferation 2 6 2.089581509435059 0.0366554089640978 1.6262135922330097 5.412621359223301 1.1035845317400614 0.2421873681292294 1.0594430818589295 1.1842969002295405 1.0977939547178823 0.257309212646388 0.0148267428903527 0.1070183553885475 0.0013262573806951 0.0173886328284286 0.09905667817091 +Regulation of protein neddylation 2 5 2.0886153070234923 0.0367423661643631 1.424757281553398 3.686893203883495 0.1969738541395791 0.5400144300750197 1.1089524004774276 0.9092422206315848 0.9660835969627868 0.3186886692947628 0.0633191306420368 0.0385773062479974 0.0743799864466655 0.1781979724676324 0.0546176715347421 +Hormone biosynthetic process 4 10 2.085180000841533 0.0370529645536166 3.2766990291262137 8.762135922330097 0.5893833627772115 0.3611309387757575 1.7820956292372838 1.0801489024333786 1.1172063688590312 0.2892911953740955 0.0187491014912179 0.007105321595433 0.0255840399150975 0.0242110622206542 0.0075753503172145 +Negative regulation of oxidoreductase activity 2 5 2.081857927522732 0.0373554487120431 1.1262135922330097 3.575242718446602 0.2632501367040795 0.4308232120454289 0.8887605818521015 0.5884558444722773 1.073417975926535 0.2798851521139121 1.0 1.0 1.0 0.2365379696877526 0.0141665154869097 +Regulation of autophagy of mitochondrion 6 15 2.077947118223044 0.0377142300541997 3.83495145631068 15.269417475728156 0.5599037905354275 0.4319133125136808 2.249474965186929 2.2839109385500524 1.0076019915675485 0.3108342800197468 0.0277307016086551 0.0106429023881486 0.0376249374527164 0.0070923684446229 0.0007278251765531 +Regulation of er to golgi vesicle mediated transport 4 6 2.076980376765269 0.0378033704011608 2.1966019417475726 5.915048543689321 0.8267152021532312 0.3699978591289015 1.4151359695885812 0.8244249231762646 0.9890575089615372 0.3183740962504898 1.0 1.0 1.0 0.2731207001200411 0.0228394808772788 +Negative regulation of cell killing 2 5 2.067020197572687 0.0387322508164529 1.3689320388349515 3.5606796116504853 0.5167799219956974 0.5078730201696048 0.9215888692497156 0.9130698908115662 0.9112362717993296 0.3251363652066285 1.0 1.0 1.0 1.0 1.0 +Antigen processing and presentation of endogenous peptide antigen 5 9 2.060629238182141 0.0393384251578088 2.638349514563106 6.390776699029126 1.097011591019633 0.2766562869747734 1.460743657586565 1.3760123823390067 1.0015631459591094 0.2785574288267012 0.1081933924999157 1.0 0.1265462710440741 0.0439142352380576 0.0037759888499611 +Antigen processing and presentation of endogenous antigen 5 9 2.060629238182141 0.0393384251578088 2.6529126213592233 6.463592233009709 1.0779744166035472 0.2832041157954688 1.4492771087670022 1.3990755299770097 1.00991421519493 0.2818848392729987 0.1154630790463651 1.0 0.1349531130589082 0.0498779046475234 0.0049531384619904 +Steroid hormone biosynthetic process 2 8 2.0569899481280216 0.0396871927814963 2.1820388349514563 6.468446601941747 0.509875024900919 0.3873819852543627 1.371827396671621 1.038798089355972 1.0610430914889264 0.2827025492365673 0.0082254277129148 0.0030581061915538 0.0113213926532688 0.0074273483269255 0.0079931710216612 +Mitochondrial fusion 8 14 2.0543994242097714 0.0399370487553514 5.730582524271845 14.140776699029129 0.9082040747396848 0.3521825448687026 2.97444400458197 2.016819417247653 1.0465735301082626 0.3054031781597867 1.0 1.0 1.0 0.0322769586697076 0.002368909886278 +Sterol biosynthetic process 9 26 2.051911267574047 0.0401782866226518 7.281553398058253 24.52912621359223 1.190088798384403 0.3136799329736269 3.292879861326439 2.61838648411319 1.1232845583768152 0.3105481837594456 0.3195763160296334 0.2067156970649581 0.3655284832956332 0.0008884443610078 1.725699745091733e-06 +Formation of extrachromosomal circular dna 0 5 2.049208195368824 0.0404417610400975 1.2427184466019416 4.871359223300971 0.3346202818185375 0.4342309628183224 1.3013511978498191 1.3312725123078977 1.0984359113559583 0.3048494268056453 0.1081933924999157 1.0 0.1265462710440741 0.290751966651369 0.5034522087350044 +Lipophagy 1 5 2.047598198965982 0.040599385975925 1.7451456310679612 4.766990291262136 0.2177000001101043 0.5599395204867244 1.3655258698104875 0.4664237727947306 0.8255666981734041 0.3051358138683513 1.0 1.0 1.0 1.0 0.0312108672695238 +Mitophagy 9 15 2.0412148401826986 0.0412294772761632 4.174757281553398 14.737864077669904 0.7026339988268726 0.4220360300693995 2.5842209186951752 2.0501535109396865 0.9566781806577936 0.318538155650451 0.2241232989350378 0.141543756104335 0.2590666885683055 0.0383377547470353 0.0033809375709235 +3 phosphoadenosine 5 phosphosulfate metabolic process 1 5 2.0398380199729544 0.0413664616370073 1.3033980582524272 4.133495145631068 0.2069577284428769 0.5232558264803253 1.1669760551932022 0.9133021371187936 0.9569939924859964 0.300200016757538 0.100864684735291 0.0619434524836269 0.1180585699575878 0.0382400085743442 0.1297945989547683 +Copi coated vesicle budding 2 6 2.0326550707512374 0.0420873834920298 1.7354368932038835 4.359223300970874 0.2179065168211083 0.3721057821405019 0.913972739389764 0.7051043981373246 1.2311252143625453 0.2964555974181374 1.0 1.0 1.0 0.1368589802283267 0.002061539822863 +Proton transporting two sector atpase complex assembly 1 5 2.0303151212576767 0.0423245181453491 1.7432098765432098 4.6839506172839505 1.079697689782964 0.2705190312822739 1.1688274457451555 1.1775111637565157 1.0292886485906785 0.2668917829180481 0.1081933924999157 0.066549445548378 0.1265462710440741 0.0439142352380576 0.1467539296032722 +Folic acid metabolic process 1 6 2.0181931169324376 0.0435711527242701 1.91747572815534 7.140776699029126 1.2977645388348351 0.249592124826322 1.215987926650751 0.8615786924829095 0.8405378716662024 0.2600707347072601 0.1081933924999157 1.0 0.1265462710440741 0.0439142352380576 0.1467539296032722 +Maintenance of protein localization in organelle 4 19 2.00908013932186 0.0445286355363134 3.866504854368932 15.29368932038835 0.5637691386290394 0.4400793840085654 2.3676920099244176 1.9777055894707407 0.9564449590017818 0.2977236914910925 0.0023797484711094 0.0112943240362007 0.0038117145357013 0.0010916803236277 0.0206839034685982 +Vesicle transport along microtubule 10 15 2.0029317978297456 0.0451846094916146 4.514563106796117 11.58980582524272 -0.102125747194735 0.5711972684164484 2.4921783572738394 1.5404554115317726 0.8762002857901487 0.2964402233799867 1.0 1.0 1.0 1.0 0.2957464229501276 +Pinocytosis 3 7 2.0004352728771213 0.0454532827437652 1.8713592233009708 7.33252427184466 0.5840579949486326 0.3745201042297812 1.4960968950914608 1.2320991783672317 1.0871891924456092 0.2933375341256155 0.1369226886862704 1.0 0.1596960736798767 0.357118555081159 0.0098879726868235 +Oxidative phosphorylation 12 61 1.9948008592069608 0.0460646036302732 18.140776699029125 60.61893203883495 0.8137621380364766 0.3661293054253088 7.750013302753429 5.582386553809936 1.7413544544034578 0.3762713520958283 0.0159836513683146 0.0204090903740193 0.0009786813716178 2.9902025799843167e-05 1.6785389152695707e-05 +Regulation of myeloid leukocyte mediated immunity 1 9 1.9898496709163216 0.0466074978994461 2.116504854368932 9.393203883495143 0.4271160580787478 0.5083359293303643 2.0351330238423526 1.7600618996132935 0.8264618558660956 0.2856631618880426 0.2112978307962688 0.1330370821365251 0.2445730022705269 0.5094216597603356 0.4165733999734724 +Positive regulation of autophagy of mitochondrion 3 6 1.986597414437796 0.0469670279834153 1.854368932038835 6.12621359223301 0.5582523218368712 0.3671654381748088 1.4221395544857194 0.967226157532586 1.067351028932407 0.2704601289024815 0.0860283086388496 0.0526645480715484 0.1008375048293403 0.0020064706347618 9.75534858956266e-05 +Chloride transport 5 13 1.9766994031147824 0.0480756183273309 4.33252427184466 12.12621359223301 1.0302584084066435 0.2341882174183942 2.3624510960969567 2.26059366569241 1.2797232968088257 0.2563105728143979 0.0293662469729552 0.0112943240362007 0.0398064357050217 0.0449350347407693 0.0046837779345005 +Histone h2a phosphorylation 0 5 1.9755467949772412 0.0482061296720908 0.75 4.526699029126213 0.6069030898696882 0.4672308023642537 1.18162509455312 0.620652472758149 0.843715948282856 0.2917097835110595 0.0556262242335954 1.0 0.0653907127050202 0.1577810442013011 0.295251642909297 +Response to ketone 9 42 1.9724544490593952 0.0485577513616974 8.135922330097088 38.38592233009709 0.3161441476593932 0.5684563546193468 3.4607326899442756 4.1947836161356875 0.8306352296989162 0.3114696972884839 0.0111741764604911 0.0966324665930835 0.0036338339198907 0.1179506058012683 0.0149727100324235 +Positive regulation of monooxygenase activity 3 6 1.9721588917735533 0.048591470802032 1.6844660194174756 5.415048543689321 1.0370130759472405 0.2898065983925483 1.0180179945339054 0.878583782950111 0.884976405150879 0.2417237008540366 0.0064177808396821 1.0 0.0088504827764808 0.0498779046475234 0.0049531384619904 +Response to food 2 5 1.963904969084921 0.0495411135007852 1.720873786407767 5.783980582524272 1.3281223897944048 0.1823213242558801 0.9790282548915298 0.8299231919143666 1.0823564620426191 0.211054619984942 0.100864684735291 0.0619434524836269 0.1180585699575878 0.2731207001200411 0.1297945989547683 +Antigen processing and presentation 13 25 1.9635459908135928 0.0495827660113099 6.201456310679611 22.17718446601942 0.8231471183465873 0.4220086818460768 2.970845032857872 3.056135613532617 0.9682333159777928 0.3245513416930483 0.0784025564630051 1.0 0.1039407380726692 0.048897845662748 0.0003775126449021 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..258fe98f004cc9f4e76194a079af6dc33b4fcc86 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 6562, + "title": "Average number of proteins per term", + "value": 20.488722950320025 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..73d674973a9d1f4b27159cba2c7f5fb017e4ec9f --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..db3703d9345bd2dbcfef717568d0b27292e1a85d --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1973 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transmembrane transport 0.5568956674323321 4.964943575787215 6.87210465383364e-07 0.0044993242000621 0.0036681637504025 213 Q13546,Q9NS69,P53985,O60831,L0R6Q1,Q9H9B4,P45880,Q07820,P46934,P21796,O60830,P06576,O75964,Q9UM00,Q8TB61,Q9C0H2,O75381,Q9UBX3,Q96GC9,Q14728,Q99595,Q96ES6,Q9Y584,Q6YHU6,P23786,P04062,Q8WTV0,Q00535,Q4KMQ2,O75844,Q03518,Q15629,Q9Y6M7,Q9UDW1,Q70HW3,Q9UHG3,P78417,Q9H2D1,O14925,Q13423,Q9HD20,P38435,Q9H2V7,O43772,O95202,Q9BSK2,P13073,Q8IXU6,P24539,P12235,P47985,Q03519,P00403,P12236,P30825,P05067,O14678,P52789,Q6P4A7,P16615,Q8IYU8,Q7KZN9,P42858,Q9Y619,P20020,Q9Y277,P0DP25,P49755,Q16625,Q9P2D1,P51798,Q96NB2,Q15388,Q07812,Q99797,Q99623,Q8NE01,Q9NUT2,P55011,P14854,Q9BQT8,Q15043,Q15041,Q8NE86,P08183,P56385,P50570,O43808,P05141,Q9UJZ1 90 +Mitochondrion organization 0.5289435579257117 4.5633147269678735 5.035224525107296e-06 0.0325013278353957 0.0036681637504025 200 P55786,Q8N2A8,Q9NS69,P42858,Q9P032,Q96CU9,P14406,Q69YU5,P30536,P45880,Q8NAN2,Q9H4A6,Q9BUR5,P21796,Q9P0J0,Q6DKK2,O43676,Q9H061,O95202,Q8N4H5,O60830,Q9Y512,Q96RL7,Q9BSK2,Q9Y5J9,Q9Y6C9,Q8NE86,Q9UBN7,P0DP25,Q9NUQ9,Q99595,P12235,Q9BWH2,O75153,Q86Y39,Q9Y584,P47985,Q99536,P04062,O14737,P03886,Q13505,Q9Y2R0,Q9Y5L4,Q7Z3C6,Q9Y6M9,Q96A26,O14965,Q8TB36,Q15388,Q5XKP0,Q9UDX5,Q9BUK6,P52789,P51970,O00203,Q07812,P27544,Q99797,P05141,Q99623,Q9NVI7,O14925,Q15070 64 +Ion transmembrane transport 0.534553694028082 4.141143868436935 3.455781097794208e-05 0.2028977174915259 0.0036681637504025 154 Q13546,P42858,P53985,Q13423,Q9NUT2,O60831,Q9HD20,Q9Y619,P55011,Q9H9B4,P45880,P14854,P46934,P21796,Q9BQT8,P20020,O43772,O95202,P06576,Q15043,O75964,Q9UM00,Q9Y277,Q15041,Q8TB61,Q8NE86,Q9C0H2,P0DP25,Q9UBX3,P13073,Q96GC9,Q14728,P08183,P24539,Q96ES6,P12235,Q6YHU6,P47985,P56385,Q00535,Q9P2D1,Q4KMQ2,O75844,P51798,P00403,P12236,Q9UDW1,Q96NB2,P30825,Q99623,Q70HW3,P05067,Q9UHG3,P78417,Q07812,P50570,O43808,Q9UJZ1,P05141,Q6P4A7,Q9H2D1,P16615,Q8IYU8,Q7KZN9 64 +Anion transport 0.6426555047949142 3.854075204809467 0.0001161678866721 0.5334256778776284 0.0041458693376167 67 Q13546,P53985,O60831,P55011,Q9Y619,Q9H9B4,P30536,P45880,P21796,Q9BQT8,Q15043,Q15041,Q9Y277,Q8TB61,Q9C0H2,Q9UBX3,Q14728,P08183,O43681,P12235,P07602,Q4KMQ2,P51798,P12236,Q96NB2,Q9Y6M7,P30825,Q9UHG3,Q15907,O43808,Q9NZJ7,P05141,Q9H2D1 33 +Anion transmembrane transport 0.734876199065179 3.8537731676286575 0.0001163113598763 0.5338647884533395 0.0041458693376167 40 Q13546,P53985,O60831,P55011,Q9Y619,Q9H9B4,P45880,P21796,Q9BQT8,Q15041,Q9Y277,Q8TB61,Q9UBX3,Q14728,P08183,P12235,Q4KMQ2,P51798,P12236,Q96NB2,P30825,Q9UHG3,O43808,P05141,Q9H2D1 25 +Vitamin d metabolic process 0.9579929988331364 3.728146421317766 0.0001928933010186 0.7180112030219592 0.0050472748015034 2 P04062 1 +Modified amino acid transport 0.9559509918319712 3.719005817724753 0.0002000084457667 0.7308769824782335 0.0050497056983845 2 Q9H2D1 1 +Ion transport 0.4675165018043275 3.7153254762659897 0.000202942298461 0.7360095922201719 0.0050497056983845 210 Q13546,P42858,P53985,Q13423,Q9NUT2,O60831,Q9HD20,Q9Y619,P55011,Q9H9B4,P45880,P30536,P14854,P46934,P17931,P21796,Q9BQT8,P20020,O43772,O95202,P06576,Q15043,O75964,Q9UM00,Q9Y277,Q15041,Q8TB61,Q8NE86,Q9C0H2,P0DP25,Q9UBX3,P13073,Q96GC9,Q14728,P08183,P24539,Q96ES6,P20337,P12235,O43681,Q9UJZ1,Q6YHU6,P47985,P56385,P07602,Q99959,Q00535,Q9P2D1,Q4KMQ2,O75844,P51798,O76024,P00403,P12236,Q9Y6M7,Q9UDW1,P30825,Q96NB2,Q99623,Q70HW3,P05067,Q9UHG3,P78417,Q15907,Q07812,P50570,Q9NZJ7,O43808,O15173,P05141,Q6P4A7,Q9H2D1,P16615,Q8IYU8,Q8NE01,Q7KZN9 76 +Microglia differentiation 0.9346557759626556 3.623054513063566 0.0002911444327331 0.8520332859850595 0.0060267816012458 2 P04062 1 +Calcium ion import into sarcoplasmic reticulum 0.927654609101512 3.591255296450572 0.0003290890756442 0.8846561859442981 0.0065438864072041 2 O75844 1 +Tetrapyrrole catabolic process 0.9783015261033204 3.5886348356016926 0.0003324140592313 0.8871463784602179 0.0065708463718001 3 P30519 1 +Response to cisplatin 0.9264877479579856 3.585943071915476 0.0003358622273668 0.8896720656600114 0.0065962616173207 2 P09601 1 +Positive regulation of glycolytic process 0.9256126021003503 3.5819565779283327 0.0003410304856386 0.8933522274316272 0.0066208344578713 2 P05067 1 +Calmodulin dependent kinase signaling pathway 0.9247374562427018 3.5779680880861644 0.0003462757166194 0.8969617249906998 0.0066414685038891 2 O75844 1 +Ornithine transport 0.9226954492415408 3.568653837497553 0.0003588201422881 0.9051065228577008 0.0066414685038891 2 P30825 1 +Membrane lipid metabolic process 0.7146607968428282 3.5685169884074965 0.0003590075791022 0.9052232081804324 0.0066414685038891 37 Q13510,O95470,P04062,P16278,Q8NBX0,O60512,P17900,P07602,O43292,P27544,Q8NCC3,P50897,Q06136,Q96G23 14 +Regulation of rna polymerase ii regulatory region sequence specific dna binding 0.9183197199533192 3.5486579641306544 0.0003871996761144 0.921235768565216 0.0068776681004381 2 O75844 1 +Sphingolipid metabolic process 0.7631491223669719 3.528775596271673 0.000417486985156 0.9354375056076624 0.0072283630516999 28 Q13510,O95470,P04062,P16278,O60512,P17900,P07602,P06280,Q07812,P27544,Q9NZJ7,Q8NCC3,P50897,Q06136,Q96G23 15 +Mitochondrial transport 0.5793278261933104 3.5208541013773433 0.0004301592264195 0.9405911529927992 0.0073776343011199 85 P55786,Q9NS69,P30536,P45880,Q9P0J0,O43772,Q8N4H5,O60830,O75964,Q9Y512,Q14849,Q9UBX3,P24539,Q99595,P12235,Q9Y584,P23786,O14737,Q9Y5L4,Q8TB36,Q15388,P52789,Q07812,Q99797,O14925,Q15070 26 +Positive regulation of triglyceride metabolic process 0.912193698949818 3.520579062758726 0.0004306055984957 0.9407649871667624 0.0073776343011199 2 Q8WTV0 1 +Regulation of response to food 0.9046091015169092 3.485676772483882 0.0004908937625931 0.960126198449438 0.0079733783914263 2 P80303 1 +Negative regulation of response to food 0.9046091015169092 3.485676772483882 0.0004908937625931 0.960126198449438 0.0079733783914263 2 P80303 1 +Regulation of appetite 0.9046091015169092 3.485676772483882 0.0004908937625931 0.960126198449438 0.0079733783914263 2 P80303 1 +Microglial cell activation 0.903442240373392 3.480293558000187 0.0005008646562993 0.9626527963482486 0.0080555732221485 2 P05067 1 +Steroid metabolic process 0.5864851085048526 3.464969285705618 0.0005302920392391 0.969214126187138 0.0083835809884993 71 P54646,Q15392,P30536,Q9BQE5,Q14534,Q16850,P38435,Q13510,O76062,Q14849,Q06520,P48449,P16435,Q14739,O95470,P04062,Q8WTV0,Q53GQ0,P05067,O15118,Q15800,P49748,P37268 23 +Negative regulation of glial cell proliferation 0.9478759446364105 3.455645561361023 0.0005489766848905 0.9727683173704644 0.0085975775805526 3 P30536 1 +Female genitalia development 0.8929404900816803 3.4316797082344808 0.0005998555510988 0.980501801260072 0.0091328355598858 2 Q9P2D1 1 +Lipid localization 0.5742199530490466 3.4224896640878253 0.0006205045689109 0.9829740184312624 0.0092991634689505 80 P30536,Q9BQE5,Q14534,Q9BUR5,Q9H2V7,Q14108,Q99720,O43772,Q9Y6B6,Q14849,P23786,Q9BXW6,P04062,Q8WTV0,P07602,O15118,O14678,P17900,Q9NZJ7 19 +Nucleotide excision repair dna gap filling 0.8888564760793418 3.412693616779125 0.000643242154019 0.985335316300894 0.0093991277196086 2 P28340 1 +Transepithelial chloride transport 0.8856476079346565 3.397744029106592 0.0006794396046789 0.988437613670784 0.0096192194653211 2 P51798 1 +Angiogenesis involved in wound healing 0.885647607934645 3.397744029106592 0.0006794396046789 0.988437613670784 0.0096192194653211 2 P42785 1 +Phosphatidylcholine catabolic process 0.9304416790644968 3.3784288687649906 0.0007290128965655 0.991650279341948 0.0098634693345634 3 Q8WTV0 1 +Manganese ion transport 0.8792298716452656 3.3677600334908333 0.0007578152458493 0.993089192727768 0.0100056008918787 2 Q9HD20 1 +Manganese ion transmembrane transport 0.8792298716452656 3.3677600334908333 0.0007578152458493 0.993089192727768 0.0100056008918787 2 Q9HD20 1 +Mitochondrial transmembrane transport 0.6258787107248942 3.360658020095409 0.0007775703667345 0.9939300294125114 0.0102252840611463 51 Q9NUT2,Q9Y619,Q9H9B4,P21796,Q9BQT8,O43772,O95202,O60830,O75964,Q9BSK2,Q8NE86,Q99595,P24539,P12235,P23786,P56385,P12236,Q96NB2,Q15388,Q8IYU8,Q9UJZ1,P05141,Q6P4A7,Q9H2D1,O14925 25 +Lipid metabolic process 0.4252224238109184 3.357033460871764 0.0007878357756727 0.9943257444133132 0.0103246970369588 294 Q6IAN0,Q15392,P53985,Q9P035,P30536,Q9BQE5,Q8N4Q0,P07099,Q16134,P06576,P16278,Q9NPH0,P52429,Q14849,A8MXV4,P50897,Q8NF37,Q9HB40,P43034,Q96G23,Q8IXJ6,P23786,O95470,P04062,Q8WTV0,P07602,P51648,O75844,Q8NCC3,Q06136,O15118,Q15800,P17900,Q86UY6,O14773,Q8TBX8,Q8NHP8,P37268,Q8N2A8,Q8NBX0,Q16850,P38435,Q13510,O76062,Q9H7Z7,Q06520,O43292,P48449,Q86YN1,A1L0T0,Q53GQ0,O00116,P49356,P05067,O14678,O60512,P49748,Q9NUQ2,P27544,Q9NZJ7,P54646,Q14534,Q8NCG7,P16435,Q14739,Q9BXW6,Q13315,Q15067,P42345,Q16836,Q07812,Q9BT22,Q99623,Q6NUM9,P15289,P06280,O95864,Q2TAA5,O15228,Q9UBM7,P48651,O43681,Q96N66,P21964,O15269,Q9BTU6,O75845,P49327,O43808,O00767,Q9UJZ1 91 +Glycolipid transport 0.9253243890715274 3.3556213244445328 0.0007918691436372 0.9944740703344356 0.0103246970369588 3 P07602 1 +Regulation of cellular response to osmotic stress 0.8766044340723369 3.355461089653649 0.0007923280176653 0.99449069775892 0.0103246970369588 2 O95202 1 +Optic nerve development 0.8716452742123559 3.332177541941268 0.0008616926475322 0.9965065473809334 0.0107908915135618 2 Q9H061 1 +Regulation of toll like receptor 9 signaling pathway 0.8687281213535488 3.318449305357756 0.0009051875174337 0.9973746221423692 0.0108902020206334 2 Q9NQC3 1 +Positive regulation of toll like receptor 9 signaling pathway 0.8687281213535488 3.318449305357756 0.0009051875174337 0.9973746221423692 0.0108902020206334 2 Q9NQC3 1 +Prostate gland growth 0.9125928350772328 3.298591840145211 0.0009717108773239 0.998303972925231 0.0111012157979039 3 P07602 1 +Vitamin transmembrane transport 0.9585522475189686 3.2867481902426765 0.0010135141814653 0.9987112114585432 0.011446953629562 4 Q9H2D1,P04062,Q8WTV0 3 +C21 steroid hormone biosynthetic process 0.908728222588339 3.281199500234662 0.0010336660342813 0.9988710017792948 0.0116345051748785 3 P30536 1 +Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway 0.8599766627771315 3.2771212484198533 0.0010487132462786 0.998977257249018 0.0117434408226629 2 Q07812 1 +Protein localization to mitochondrion 0.5949118653974275 3.269736187475432 0.001076478278261 0.999147770953623 0.0119219977441515 59 P55786,Q9NS69,P30536,Q9P0J0,Q8N4H5,O60830,Q9Y512,Q9Y6C9,P0DP25,Q99595,Q9Y584,O14737,Q9Y5L4,Q8TB36,Q15388,P52789,Q07812,Q99797,O14925,Q15070 20 +Ectopic germ cell programmed cell death 0.8567677946324409 3.2619134222156605 0.0011066293614609 0.999300904249446 0.0120226852150803 2 Q07812 1 +Programmed cell death involved in cell development 0.8567677946324409 3.2619134222156605 0.0011066293614609 0.999300904249446 0.0120226852150803 2 Q07812 1 +Immunoglobulin v d j recombination 0.8567677946324243 3.2619134222156037 0.0011066293614612 0.999300904249447 0.0120226852150803 2 Q13426 1 +Sterol metabolic process 0.6436917639400898 3.249651528480841 0.0011554650167477 0.9994927696297022 0.0124912050080708 42 P54646,P05067,Q15392,O15118,O76062,P04062,Q15800,Q8WTV0,P49748,Q14849,Q9BQE5,Q14534,Q16850,Q06520,P48449,P16435,Q14739,P37268 18 +Necroptotic signaling pathway 0.8503500583430569 3.2314098546563237 0.001231811717423 0.999692836703194 0.0131433308776097 2 P49327 1 +Secondary alcohol metabolic process 0.6267980813434416 3.2211034708533286 0.0012769803569745 0.9997717113951812 0.0134936314049387 46 P54646,P05067,Q15392,O15118,O76062,P04062,Q15800,Q8WTV0,P49748,Q14849,Q9BQE5,Q14534,Q16850,Q06520,P48449,P16435,Q14739,P37268 18 +Positive regulation of dendritic cell differentiation 0.8456826137689624 3.209151387605359 0.0013312737694042 0.9998402081494568 0.01381616624689 2 P09429 1 +Organic anion transport 0.6343980162697987 3.2034372604016217 0.0013579762501023 0.999865922977292 0.014055268380397 43 P53985,O60831,P55011,Q9Y619,Q9H9B4,Q9BQT8,Q15041,Q8TB61,Q9UBX3,Q14728,P12235,P07602,P12236,Q96NB2,Q9Y6M7,P30825,O43808,Q9NZJ7,P05141,Q9H2D1 20 +Intrinsic apoptotic signaling pathway in response to osmotic stress 0.8421820303383915 3.1924163711873925 0.0014108779330652 0.999905292581876 0.0144659078074598 2 Q92974 1 +Cell adhesion molecule production 0.8413068844807378 3.1882270837360513 0.0014314806907631 0.9999172846972854 0.0146002874072531 2 Q9H4A6 1 +Protein auto adp ribosylation 0.838973162193687 3.1770448007374936 0.0014878405038238 0.9999428870486052 0.0150899681392463 2 Q9UGN5 1 +Diacylglycerol metabolic process 0.8386814469078033 3.1756459041766134 0.0014950331815313 0.9999455239006828 0.0151395181129761 2 Q8NCC3 1 +Retinal rod cell development 0.8372228704783996 3.168647711402555 0.0015314990486199 0.999957132653416 0.0152316089912518 2 P54802 1 +Retinal rod cell differentiation 0.8372228704783996 3.168647711402555 0.0015314990486199 0.999957132653416 0.0152316089912518 2 P54802 1 +Camera type eye photoreceptor cell differentiation 0.8372228704783996 3.168647711402555 0.0015314990486199 0.999957132653416 0.0152316089912518 2 P54802 1 +Autophagosome membrane docking 0.835764294048998 3.161643327472018 0.0015688159188933 0.9999664560372316 0.0153879970998179 2 P16615 1 +Establishment of planar polarity of embryonic epithelium 0.8337222870478398 3.1518267683976555 0.0016225250218329 0.9999764328335592 0.0157035533824005 2 P43034 1 +Regulation of oocyte maturation 0.8325554259043186 3.146211837088061 0.0016540015996968 0.9999808372891104 0.0158910080486249 2 O14965 1 +Regulation of cell maturation 0.8325554259043186 3.146211837088061 0.0016540015996968 0.9999808372891104 0.0158910080486249 2 O14965 1 +Positive regulation of cell maturation 0.8325554259043186 3.146211837088061 0.0016540015996968 0.9999808372891104 0.0158910080486249 2 O14965 1 +Chromosome localization to nuclear envelope involved in homologous chromosome segregation 0.8281796966161005 3.1251203148192976 0.0017773234900588 0.9999914806739292 0.0168060043673752 2 Q13315 1 +Positive regulation of coagulation 0.8273045507584513 3.1208952614581817 0.0018030214987247 0.999992804869438 0.0168060043673752 2 P32119 1 +Positive regulation of biomineralization 0.8273045507584496 3.1208952614581817 0.0018030214987247 0.999992804869438 0.0168060043673752 2 P20020 1 +Positive regulation of bone mineralization 0.8273045507584496 3.1208952614581817 0.0018030214987247 0.999992804869438 0.0168060043673752 2 P20020 1 +Peripheral nervous system axon regeneration 0.9201487708820066 3.12007129800843 0.0018080727051801 0.999993039867478 0.0168291816899177 4 P30536 1 +Regulation of response to osmotic stress 0.8724832214765108 3.116201997967905 0.0018319673630182 0.9999940516380662 0.0169939577111474 3 Q92974,O95202 2 +Regulation of triglyceride metabolic process 0.8707324190253705 3.108144438008262 0.001882660327283 0.9999957375263324 0.0172783455491344 3 Q8NCG7,Q8WTV0 2 +Chorion development 0.8226371061843523 3.0983235026526623 0.0019461885613998 0.9999971928273814 0.0177127452703269 2 Q15363 1 +Extraembryonic membrane development 0.8226371061843523 3.0983235026526623 0.0019461885613998 0.9999971928273814 0.0177127452703269 2 Q15363 1 +Xenobiotic transport 0.8217619603267241 3.094084128662758 0.00197421496178 0.9999976652441032 0.0178686876954514 2 P08183 1 +Photoreceptor cell maintenance 0.8217619603267208 3.0940841286627245 0.0019742149617802 0.9999976652441032 0.0178686876954514 2 Q15555 1 +Negative regulation of amyloid precursor protein biosynthetic process 0.8669608668165601 3.090759167615829 0.0019964549069659 0.9999979828643478 0.0179955179938335 3 Q9Y287 1 +Pyramidal neuron differentiation 0.9119192777713502 3.0838961835691547 0.0020430887685565 0.9999985155448728 0.0182653249308827 4 P04062 1 +T cell tolerance induction 0.8191365227537935 3.0813523800849194 0.0020606262499258 0.9999986772270943 0.018335952134834 2 P01889 1 +Lymphocyte anergy 0.8191365227537935 3.0813523800849194 0.0020606262499258 0.9999986772270943 0.018335952134834 2 P01889 1 +Iron ion transmembrane transport 0.8162193698949867 3.0671819609935858 0.0021608727289732 0.9999993157819336 0.0189567471223621 2 Q15043 1 +Heme transport 0.8162193698949666 3.067181960993494 0.0021608727289739 0.9999993157819336 0.0189567471223621 2 O15173 1 +Iron coordination entity transport 0.8162193698949666 3.067181960993494 0.0021608727289739 0.9999993157819336 0.0189567471223621 2 O15173 1 +Spindle assembly involved in female meiosis 0.8613948059527283 3.065032322118071 0.0021764647436774 0.9999993824626776 0.0190510111774233 3 O14777,O95067 2 +Protein retention in golgi apparatus 0.8598503779663926 3.057879060313753 0.0022290951885031 0.9999995631385508 0.0193773328883757 3 Q9H4A6 1 +Organic acid transmembrane transport 0.6839376113529791 3.057794605603235 0.0022297234750208 0.9999995649399502 0.0193773328883757 29 O14678,P53985,Q15041,O60831,Q9Y619,Q9H2D1,Q9UBX3,Q9BQT8,P08183,O43772,Q96NB2,P30825,P23786 13 +Maintenance of protein location in mitochondrion 0.8597534384513177 3.0574298550492824 0.0022324388393191 0.9999995726403188 0.0193773328883757 3 P30536 1 +Protein insertion into membrane 0.6813460518457098 3.040752561319751 0.0023598767937946 0.999999815166842 0.0202955590050861 29 Q96A33,P46379,Q9Y512,Q9NS69,Q9Y5J9,O14737,Q9Y5L4,Q07812,Q9P0J0,Q7L5D6,O43681,Q15629,Q15070,Q9Y584 14 +Toll like receptor 9 signaling pathway 0.8554407447251873 3.03741968076651 0.0023861298516976 0.9999998444804842 0.0204143208433373 3 Q9NQC3 1 +Nucleobase transport 0.8543915961482268 3.0325441891356752 0.0024250158923018 0.9999998795799896 0.020564018479959 3 P12235,Q9Y277 2 +Mitochondrial adp transmembrane transport 0.8543915961482227 3.0325441891356477 0.002425015892302 0.9999998795799896 0.020564018479959 3 P12236,P12235 2 +Mitochondrial respiratory chain complex assembly 0.6248338403920288 3.019101019451129 0.0025352598014372 0.9999999416904118 0.0212944269955454 39 Q9Y512,Q9P032,Q9BSK2,Q96CU9,P03886,Q69YU5,Q9Y2R0,Q7L592,P51970,Q9Y6M9,Q9P0J0,Q6DKK2,O43676,Q9H061,Q86Y39,Q15070,P47985 17 +Fatty acid elongation 0.8063010501750314 3.018812202594807 0.0025376778284846 0.9999999426106296 0.0212944269955454 2 Q9P035 1 +Negative regulation of programmed necrotic cell death 0.8505981908374661 3.0148909202303926 0.00257071691099 0.9999999538220936 0.0214061319932786 3 Q92974,P12235 2 +Negative regulation of necrotic cell death 0.8505981908374661 3.0148909202303926 0.00257071691099 0.9999999538220936 0.0214061319932786 3 Q92974,P12235 2 +Antigen processing and presentation of lipid antigen via mhc class ib 0.805425904317389 3.014530087425359 0.0025737768154321 0.9999999547424008 0.0214061319932786 2 O00203 1 +Nk t cell differentiation 0.805425904317389 3.014530087425359 0.0025737768154321 0.9999999547424008 0.0214061319932786 2 O00203 1 +Regulation of nk t cell differentiation 0.805425904317389 3.014530087425359 0.0025737768154321 0.9999999547424008 0.0214061319932786 2 O00203 1 +Process utilizing autophagic mechanism 0.4229236189412625 2.9985715182466617 0.0027124848572763 0.9999999818302838 0.0221384647182183 173 P54646,P42858,Q93050,P30536,Q9Y5X3,Q07820,P46934,P09601,P21796,Q96DM3,Q9BQS8,Q96HY6,P42574,Q15382,Q96RL7,Q9UBN7,Q96GC9,P12235,Q9BWH2,Q8IXJ6,P09429,P04062,P13473,Q86UE4,O15269,Q13315,P07602,Q7Z3C6,Q969Q5,O75844,Q9Y487,Q9NZ45,O15118,P42345,P52789,Q8TBX8,P10619,P27544,Q9NZJ7,P05141,Q99623,P16615 42 +Chemosensory behavior 0.8468047855266982 2.997198428430262 0.002724732958685 0.99999998323715 0.0221832477355969 3 O76024,Q9P2D1 2 +Olfactory behavior 0.8468047855266982 2.997198428430262 0.002724732958685 0.99999998323715 0.0221832477355969 3 O76024,Q9P2D1 2 +Regulation of dendritic cell differentiation 0.8459293843011384 2.993109959076339 0.0027615023526974 0.99999998683949 0.0223715783190132 3 P09429,P01889 2 +Mitochondrial membrane organization 0.5843502974317231 2.9925644665628113 0.0027664423290088 0.999999987260407 0.0223839637027814 50 Q9NS69,Q9Y512,Q9Y5J9,Q5XKP0,Q15070,P12235,O14737,Q13505,Q9Y5L4,P45880,P52789,O00203,P0DP25,Q07812,Q9BUR5,Q9P0J0,O95202,Q9Y584 18 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.6885470291850249 2.9877118598391084 0.0028107440989364 0.999999990481916 0.0226864732807145 27 P42858,P24390,O43731,Q9P2W9,Q9H4A6,Q9Y282,P18085,P49755 8 +Histone h3 k4 dimethylation 0.7987164527421096 2.9816235640073687 0.0028672431406409 0.9999999934373708 0.0229555122224373 2 Q03164 1 +Histone h3 k4 monomethylation 0.7987164527421096 2.9816235640073687 0.0028672431406409 0.9999999934373708 0.0229555122224373 2 Q03164 1 +Neutral lipid biosynthetic process 0.8887597172574662 2.981202879853937 0.002871185102875 0.9999999936054268 0.0229555122224373 4 Q8WTV0 1 +Protection from natural killer cell mediated cytotoxicity 0.7966744457409598 2.9715814087753647 0.0029627031613097 0.9999999964986404 0.0233950158177071 2 P01889 1 +Detection of other organism 0.7966744457409598 2.9715814087753647 0.0029627031613097 0.9999999964986404 0.0233950158177071 2 P01889 1 +Membrane protein intracellular domain proteolysis 0.7952158693115381 2.9644006615896825 0.0030327314128155 0.9999999977916528 0.0234104456263593 2 Q8TCT9 1 +Positive regulation of protein neddylation 0.8395097753136636 2.963063590563443 0.0030459363642625 0.9999999979754868 0.0234104456263593 3 Q96GG9,Q92564 2 +Keratan sulfate metabolic process 0.8362662954274569 2.9478396297313383 0.0032000302502335 0.9999999992658212 0.023861842115476 3 P16278 1 +Positive regulation of neurotransmitter secretion 0.7917152858809816 2.947140352568633 0.0032072759442005 0.9999999993000188 0.023861842115476 2 Q00535 1 +Calcium ion regulated exocytosis of neurotransmitter 0.7917152858809653 2.9471403525685473 0.0032072759442014 0.9999999993000188 0.023861842115476 2 P16615 1 +Fluid transport 0.7908401400233349 2.942819414050126 0.0032523807710891 0.9999999994798504 0.0241426726469309 2 Q99797 1 +Nitrogen compound transport 0.3570593604746288 2.9374071771911368 0.0033096923475366 0.999999999643334 0.024402473241051 608 P55060,Q13546,Q9NS69,P24390,P53985,O75165,O60831,L0R6Q1,P30536,Q9H9B4,Q2M389,A6NIH7,Q07820,P46934,Q14108,P43307,Q8N4H5,O60830,O75955,O15400,Q8TB61,O76094,O75381,Q9Y5X2,Q96GC9,P50897,Q99595,P43034,P20337,O43731,Q9Y584,P41208,P07602,Q9Y282,Q03518,Q15629,Q9BTX1,Q9P2W9,Q15907,P10619,O15173,Q9H2D1,P46379,O14925,Q13432,Q15070,P55786,Q9Y3B3,Q7Z4Q2,Q9HD20,O60725,Q16850,Q9P0J0,O43772,P52292,P57105,O15127,Q9BSK2,Q96P70,Q9Y5M8,P12235,Q5T9L3,Q03519,P13473,Q9Y5L4,Q969Q5,Q96KC8,P53367,Q8N5M9,Q9BUN8,P12236,Q96PC5,P30825,O14678,Q15363,Q9NZJ7,Q6P4A7,Q9NR31,O95249,Q13277,Q5HYI8,Q9Y619,Q9Y5X3,Q9H4A6,Q8TCT9,Q96RL7,Q9Y277,Q9Y6B6,Q13190,P49755,Q99584,A0AVF1,O15260,O14737,Q9P2D1,Q658Y4,O15397,Q96NB2,Q8TB36,Q15388,Q16836,Q96D46,Q07812,Q96KP1,Q99797,Q99623,O95391,Q15154,P55011,Q9C0E2,Q9Y512,Q9Y5J9,Q15041,Q9BVK6,Q8NE86,Q92974,O95613,Q15904,Q9UBN7,Q96QU8,P08183,O43681,P61020,Q92973,Q7L5D6,P18085,P61970,Q12907,O00203,P50570,O43808,P05141 132 +Regulation of autophagy 0.4996968371299837 2.9269859334343 0.0034226436053357 0.9999999998304564 0.0249481935851839 103 P54646,P42858,Q93050,P30536,Q9Y5X3,Q07820,P46934,P09601,P21796,Q96DM3,Q9BQS8,Q15382,Q9UBN7,P12235,P09429,P04062,Q86UE4,O15269,Q13315,P07602,O75844,Q9Y487,Q9NZ45,O15118,P42345,Q8TBX8,P10619,P27544,Q9NZJ7,P05141 30 +Cation transmembrane transport 0.4744201763516428 2.926647571680444 0.0034263690869382 0.9999999998345648 0.0249481935851839 120 P42858,Q13423,Q9NUT2,Q9HD20,Q9Y619,P55011,Q9H9B4,P14854,P46934,P21796,P20020,O43772,O95202,P06576,Q15043,O75964,Q9UM00,Q8NE86,P0DP25,P13073,Q96GC9,P24539,Q96ES6,P12235,Q6YHU6,P47985,P56385,Q00535,Q9P2D1,Q4KMQ2,P00403,Q9UDW1,Q96NB2,P30825,Q70HW3,P05067,P78417,Q07812,P50570,Q9UJZ1,P05141,Q99623,P16615,Q8IYU8,Q7KZN9 45 +Lytic vacuole organization 0.709173740868375 2.926455899062615 0.0034284811071383 0.9999999998368496 0.0249481935851839 24 Q8N511,P04062,O14773,O75503,P50897,Q14108,P11117,P54802,P10253 9 +Alpha ketoglutarate transport 0.7855892648774784 2.9168443803769275 0.0035359214138297 0.999999999919586 0.0252964963395078 2 Q9BQT8 1 +Plasma membrane phospholipid scrambling 0.8275459585643419 2.9067643094289934 0.0036518823778537 0.9999999999625312 0.0257755146881071 3 Q7Z3C6,Q96GC9 2 +Positive regulation of striated muscle cell differentiation 0.8721352242109941 2.906665416034515 0.0036530369795702 0.9999999999628152 0.0257755146881071 4 Q9UGN5 1 +Positive regulation of heart rate 0.782380396732773 2.900928920747619 0.0037205826228263 0.999999999976168 0.0260643536173406 2 P16615 1 +Membrane lipid biosynthetic process 0.7231654297208161 2.8967111918751187 0.003770967312648 0.9999999999828986 0.0262130164254199 22 Q13510,O95470,P04062,Q8NBX0,O60512,O43292,Q06136,Q96G23 8 +Hormone catabolic process 0.8244236552183837 2.8920058575920757 0.0038279081003742 0.9999999999882472 0.0265072258458355 3 P42892 1 +Phosphatidylinositol acyl chain remodeling 0.7803383897316243 2.890784319464603 0.0038428175084748 0.9999999999893466 0.0265158448902331 2 Q96N66 1 +Protein targeting 0.4738743494721076 2.880783055613234 0.0039668858047627 0.9999999999952952 0.0269660918496983 118 P55786,Q9NS69,P30536,O60725,Q9P0J0,Q14108,P43307,Q8N4H5,O60830,P57105,Q9Y512,Q96RL7,Q9Y5J9,Q15041,Q9Y5M8,Q99595,Q9Y584,P13473,O14737,Q9Y5L4,Q15629,Q8TB36,Q15388,Q99797,P46379,O14925 26 +Calcium ion export across plasma membrane 0.8209327610993251 2.8754728444326036 0.004034228459816 0.9999999999969812 0.0273477346625133 3 P20020 1 +Epithelial cell differentiation involved in prostate gland development 0.8207136435602984 2.8744339547378166 0.0040475241278423 0.9999999999972344 0.0273661995742287 3 P07602 1 +Middle ear morphogenesis 0.8204119214351264 2.873003195830848 0.0040659000334404 0.9999999999975496 0.0274029965651178 3 P54802 1 +Establishment of protein localization to membrane 0.510379076184712 2.8729943119029793 0.0040660143700477 0.9999999999975516 0.0274029965651178 89 Q9NS69,Q13277,Q9HD20,O60725,Q9H4A6,Q9P0J0,P43307,Q9Y512,Q9Y5J9,Q15041,Q15904,P0DP25,O43681,Q96A33,Q9Y584,O14737,Q9Y5L4,Q7L5D6,Q15629,O15118,O00203,Q15907,Q07812,P46379,Q15070 25 +Regulation of tolerance induction 0.8193755471257622 2.868086785570399 0.0041296223977154 0.9999999999983898 0.0275221731502121 3 P09429,P01889 2 +Tolerance induction 0.8193755471257622 2.868086785570399 0.0041296223977154 0.9999999999983898 0.0275221731502121 3 P09429,P01889 2 +Protein targeting to mitochondrion 0.582173139663175 2.867961203230733 0.0041312618946904 0.9999999999984072 0.0275221731502121 46 P55786,Q8TB36,Q9NS69,Q9Y512,Q15388,O14737,P30536,Q9Y5L4,Q9P0J0,Q99797,Q99595,Q9Y584,O14925,Q8N4H5,O60830 15 +Post embryonic animal organ development 0.7750875145857579 2.864638769796538 0.0041748518575983 0.9999999999988048 0.0276720988783438 2 Q07812 1 +Membrane organization 0.4102923994825913 2.856355218885162 0.0042853539729608 0.999999999999423 0.0281578030334452 227 Q15392,Q9NS69,O95249,Q13277,P30536,P45880,Q86XL3,Q9H4A6,Q9BUR5,Q9P0J0,O95202,Q8NHH9,O75955,O15400,Q9Y512,Q9Y5J9,Q15041,Q9BVK6,Q9Y6B6,Q14849,O15228,Q13190,P0DP25,P49354,Q96GC9,P50897,P08183,P43034,O43681,P12235,O95487,P49755,Q9Y584,Q8IXJ6,Q96A33,Q8NFQ8,Q9H5V9,Q6UXV4,O14737,Q13505,Q9Y5L4,Q7Z3C6,O94901,O75844,Q7L5D6,Q15629,Q9UQB8,O15118,P57088,P16615,Q5XKP0,Q9P2W9,P52789,O00203,Q15363,Q07812,P50570,Q9NZJ7,P05141,Q9NR31,P46379,Q9NPA0,Q9BTV4,Q15070,Q9NQC3 65 +Regulation of lipophagy 0.8161676944787787 2.8528500355828283 0.0043329063759036 0.9999999999995782 0.0282910762573929 3 P42858 1 +Adp transport 0.8546409807355375 2.82747303772111 0.0046916966126895 0.9999999999999604 0.0300360128511904 4 P12236,P12235,O43808 3 +Positive regulation of mitophagy 0.8546409807355329 2.827473037721095 0.0046916966126897 0.9999999999999604 0.0300360128511904 4 P27544,P12235,P21796 3 +Lipid phosphorylation 0.7666277712952203 2.822334420689943 0.0047675433772793 0.999999999999976 0.0304029345400458 2 P52429 1 +Inorganic anion transport 0.6823103682063983 2.819704948609576 0.0048067824497255 0.9999999999999816 0.0306234043059213 25 Q9UHG3,Q9Y277,P55011,P30536,P45880,Q9C0H2,Q9UBX3,P51798,P21796,P08183,Q15043 11 +Axon ensheathment in central nervous system 0.7657526254375735 2.8179453018523124 0.0048332042744287 0.9999999999999843 0.0307618685245409 2 Q92542 1 +Sphingolipid biosynthetic process 0.7870114062415207 2.816749265724466 0.0048512381928851 0.999999999999986 0.0308266298748971 15 Q13510,O95470,P04062,O60512,Q06136,Q96G23 6 +Labyrinthine layer morphogenesis 0.8083162083417963 2.8154341644702563 0.004871137637328 0.999999999999988 0.0309133512341843 3 Q15363 1 +Peptidyl serine autophosphorylation 0.8081283454591277 2.8145367723108845 0.0048847588760116 0.9999999999999888 0.0309698432312934 3 Q13315 1 +Neutrophil differentiation 0.8514302393461667 2.8128536723929978 0.0049103990809 0.9999999999999908 0.0310592467858876 4 Q14739,P49327,Q8N5M9 3 +Maintenance of protein localization in endoplasmic reticulum 0.88456309960796 2.812679472805239 0.0049130597628392 0.9999999999999908 0.0310592467858876 5 O43731,P24390 2 +Protein retention in er lumen 0.88456309960796 2.812679472805239 0.0049130597628392 0.9999999999999908 0.0310592467858876 5 O43731,P24390 2 +Organophosphate ester transport 0.6803625643812541 2.807411489258559 0.0049941402036723 0.9999999999999946 0.0315111038620175 25 Q9BSK2,Q8WTV0,Q8TB61,Q7Z3C6,O43808,Q96GC9,P05141,Q14108,P08183,Q9H2D1,P12236,P12235 12 +Sphingosine biosynthetic process 0.8493216919002488 2.8032384399407584 0.0050592250568732 0.9999999999999964 0.0317876491777595 4 Q13510,P04062 2 +Zinc ion homeostasis 0.8056609279252922 2.802740980861159 0.0050670345991976 0.9999999999999968 0.0317876491777595 3 Q15043,O00203 2 +Antigen processing and presentation via mhc class ib 0.8056609279252909 2.802740980861145 0.0050670345991978 0.9999999999999968 0.0317876491777595 3 Q03519,O00203 2 +Steroid biosynthetic process 0.5644463692036686 2.7993556526415753 0.005120470468144 0.9999999999999976 0.0320053052963474 49 P54646,Q13510,Q15392,O76062,Q15800,Q53GQ0,Q14849,P30536,Q14534,Q16850,P48449,P16435,Q14739,P37268 14 +Hormone metabolic process 0.6446473941206948 2.795706497579628 0.0051786406745728 0.9999999999999984 0.0322412145223406 29 O95470,P42892,Q53GQ0,Q14849,P30536,P14735,Q06520,O75844,Q9HB40,P16435,Q6NUM9 11 +Response to corticosterone 0.8040612154271887 2.7950840958126366 0.0051886216132008 0.9999999999999986 0.0322621247945776 3 P20020 1 +Regulation of mammary gland epithelial cell proliferation 0.847161439075353 2.7933755175942685 0.0052161100715857 0.9999999999999988 0.0322906738582505 4 Q07812,Q9NQC3 2 +Establishment of protein localization 0.3507655601569476 2.790457823544364 0.0052633557214882 0.9999999999999992 0.0324911949618119 561 P55060,Q9NS69,P24390,P53985,O75165,O60831,P30536,Q2M389,A6NIH7,Q07820,P46934,Q14108,P43307,Q8N4H5,O60830,O15400,O76094,O75381,Q9Y5X2,Q96GC9,P50897,Q99595,P43034,P20337,O43731,Q9Y584,P41208,Q9Y282,Q03518,Q15629,Q9H7B4,O15118,Q9BTX1,Q9P2W9,Q15907,P10619,P46379,O14925,Q13432,Q15070,P55786,Q9Y3B3,Q7Z4Q2,Q9HD20,O60725,Q16850,Q9P0J0,P52292,P57105,O15127,Q96P70,Q9Y5M8,Q5T9L3,Q03519,P13473,Q9Y5L4,Q969Q5,Q96KC8,P53367,Q8N5M9,Q9BUN8,Q96PC5,P52789,Q15363,Q9NR31,O95249,Q13277,Q5HYI8,Q9Y5X3,Q9H4A6,Q8TCT9,Q96RL7,Q9Y6B6,Q13190,P0DP25,P49755,Q99584,Q96A33,A0AVF1,O15260,O14737,Q658Y4,O15397,Q8TB36,Q15388,Q16836,Q96D46,Q07812,Q96KP1,Q99797,Q99623,O95391,Q15154,P55011,P11279,Q9C0E2,Q9Y512,Q9Y5J9,Q15041,Q9BVK6,Q8NE86,Q92974,O95613,Q15904,Q9UBN7,Q96QU8,O43681,P61020,Q92973,Q7L5D6,P18085,P61970,Q12907,O00203,P50570,Q9NPA0 116 +Ceramide metabolic process 0.7471291212596842 2.7897977425887377 0.0052740977584802 0.9999999999999992 0.0325182384085814 18 Q13510,O95470,P04062,O60512,P17900,P06280,P27544,Q8NCC3,Q96G23 9 +Vacuole organization 0.5487170855947194 2.7796585555437416 0.0054416081267278 0.9999999999999996 0.0333406466177296 53 Q8N511,P04062,O14773,Q8TBX8,O75503,P50897,Q14108,P16615,P11117,P54802,P10253 11 +Positive regulation of nitric oxide synthase activity 0.843894127209588 2.778435223366625 0.0054621402770684 0.9999999999999998 0.0334352280766076 4 P00374,Q8WTV0 2 +Endoplasmic reticulum organization 0.5792972598453703 2.7759463141110015 0.005504129623955 0.9999999999999998 0.033629514518057 43 Q8NHH9,Q8NFQ8,P46379,P57088,Q15041,O95197,Q9P2W9,Q12907,Q15363,Q8N5M9,Q7L5D6,O43681,Q15629,Q96A33,Q9NQC3 15 +Protein o linked glycosylation via threonine 0.7990523837978797 2.7710625015887143 0.0055873700730342 1.0 0.0339960423199621 3 Q8N4A0 1 +Cellular response to ether 0.7989303151966982 2.770476183239984 0.0055974393637396 1.0 0.0339960423199621 3 Q9H4A6 1 +Regulation of hormone levels 0.5198754251172267 2.7665774182839606 0.0056648132601446 1.0 0.0341805766787338 68 O95470,P42892,Q16836,Q8NE86,Q53GQ0,Q14849,P30536,P14735,Q06520,Q9P2D1,Q15907,O75844,Q8N5M9,Q9HB40,P16435,Q6NUM9,Q15043 17 +Detection of external biotic stimulus 0.796906915669655 2.760751193904888 0.0057668591168169 1.0 0.0345590223968519 3 P01889,Q8WTV0 2 +C21 steroid hormone metabolic process 0.8388679400140506 2.7553981029376295 0.0058620760767758 1.0 0.0350017681672455 4 P30536 1 +Sulfur compound transport 0.9044734956804812 2.7539956324990995 0.0058872553793412 1.0 0.0351201543629427 6 Q8TB61,Q9UBX3 2 +Lung alveolus development 0.7925299095418721 2.739673923397563 0.0061500166011554 1.0 0.0358723634993617 3 O60476,Q16706 2 +Mitochondrion endoplasmic reticulum membrane tethering 0.7910709074992675 2.732635912200003 0.0062829743070238 1.0 0.0365504232293355 3 P16615,Q96GC9 2 +Regulation of cd40 signaling pathway 0.7464994165694103 2.7207716775206383 0.0065129729156687 1.0 0.0376215917892768 2 O15360 1 +Regulatory t cell differentiation 0.7464994165694103 2.7207716775206383 0.0065129729156687 1.0 0.0376215917892768 2 O15360 1 +Maternal placenta development 0.8308778832572682 2.71864077267981 0.0065550755730163 1.0 0.0378314915656406 4 Q15363 1 +Cation transport 0.4195051830987163 2.7173716214526675 0.0065802677589226 1.0 0.0379435123322058 160 P42858,Q13423,Q9NUT2,Q9HD20,Q9Y619,P55011,Q9H9B4,P30536,P14854,P46934,P17931,P21796,P20020,O43772,O95202,P06576,Q15043,O75964,Q9UM00,Q8NE86,P0DP25,P13073,Q96GC9,P24539,Q96ES6,P20337,P12235,Q6YHU6,P47985,P56385,Q99959,Q00535,Q9P2D1,Q4KMQ2,O75844,O76024,P00403,Q9UDW1,Q96NB2,P30825,Q70HW3,P05067,P78417,Q15907,Q07812,P50570,O43808,Q9UJZ1,O15173,P05141,Q99623,P16615,Q8IYU8,Q7KZN9 54 +Chemical homeostasis 0.4003507143463279 2.6996529129219144 0.0069411849402176 1.0 0.0394697188714977 187 P54646,P30519,P42858,P53985,Q93050,Q9HD20,P55011,Q9P035,P30536,Q9Y5X3,P09601,P20020,O95202,Q5BJF2,Q8N511,P06576,O43819,Q15043,Q9UM00,Q9Y6C9,Q9Y6B6,P09874,Q8NE86,Q15904,P42785,P0DP25,P50897,Q8NF37,Q9BWH2,Q96A33,P09429,P04062,O15260,Q8WTV0,Q9P2D1,O76024,Q8N5M9,Q9H1E3,Q9Y487,P05067,O15118,Q15067,P78417,P52789,O00203,Q15907,Q07812,P28340,Q9UJZ1,O75503,P16615,Q8IYU8,Q8NE01,Q9NQC3 54 +Vitamin transport 0.8914582213640558 2.6978042425865847 0.0069798471834168 1.0 0.0396552010541828 6 Q9H2D1,P38435,P04062,Q8WTV0 4 +Luteolysis 0.7418319719953381 2.6970365125792166 0.006995959896183 1.0 0.0396866559848799 2 P42574 1 +Carboxylic acid transport 0.6168925789708679 2.6956135448779976 0.0070259127541989 1.0 0.0397791540060858 32 P53985,Q15041,O60831,P55011,Q9Y619,P07602,Q9UBX3,Q9NZJ7,Q9BQT8,Q9H2D1,Q96NB2,P30825 12 +Negative regulation of mitochondrial fusion 0.7829004960606958 2.693109386345351 0.007078903986478 1.0 0.0399813248032399 3 Q99536,Q7Z6Z7 2 +Inorganic ion transmembrane transport 0.4627684453944936 2.6930625114287907 0.0070798993327285 1.0 0.0399813248032399 115 P42858,Q13423,Q9NUT2,Q9HD20,P55011,P14854,P46934,P21796,P20020,O95202,P06576,Q15043,O75964,Q9UM00,Q8NE86,P0DP25,Q9UBX3,P13073,Q96GC9,P24539,Q96ES6,P12235,Q6YHU6,P47985,P56385,Q00535,Q9P2D1,Q4KMQ2,P51798,P00403,Q9UDW1,Q9UHG3,P78417,Q07812,P50570,Q9UJZ1,P05141,Q99623,P16615,Q8IYU8,Q7KZN9 41 +Serine transport 0.782618160791797 2.6917400579579778 0.0071080322618237 1.0 0.0400422916045883 3 Q96NB2 1 +Sphingoid metabolic process 0.8555810458772289 2.6838432639840653 0.0072781217914523 1.0 0.0406806091954944 5 Q13510,P04062,Q06136 3 +Positive regulation of monocyte chemotaxis 0.7804127905468536 2.681036025075313 0.0073394614224471 1.0 0.0409536954541649 3 P09429 1 +Corpus callosum development 0.7799824919754832 2.6789458700309914 0.007385433194603 1.0 0.0411752018886875 3 P43034,Q00535 2 +Organic acid transport 0.5579958786349283 2.6706312727877077 0.0075708761612967 1.0 0.0419083699006931 46 O14678,P53985,Q15041,O60831,P55011,Q9Y619,Q9H2D1,Q9UBX3,O43808,Q9BQT8,P08183,O43772,Q6P4A7,Q96NB2,P30825,P23786 16 +Glycosylceramide catabolic process 0.777044503257155 2.664660323262277 0.0077066121751174 1.0 0.0424964614227906 3 P04062 1 +Establishment of protein localization to mitochondrial membrane 0.7123985025137921 2.660471440314094 0.0078031344625715 1.0 0.0428845631016703 19 Q9Y512,Q9NS69,Q9Y5J9,O14737,Q9Y5L4,P0DP25,Q07812,Q9P0J0,Q15070,Q9Y584 10 +Protein poly adp ribosylation 0.7752723856663527 2.65603149140108 0.0079066230511664 1.0 0.0431282298102693 3 Q9UGN5 1 +Granzyme mediated programmed cell death signaling pathway 0.7327887981330121 2.650850197461485 0.0080289443703516 1.0 0.0436503172810665 2 P11279 1 +Regulation of hormone biosynthetic process 0.7324970828471217 2.6493559199452985 0.008064535064348 1.0 0.0437351066878112 2 P16435 1 +Regulation of steroid hormone biosynthetic process 0.7324970828471217 2.6493559199452985 0.008064535064348 1.0 0.0437351066878112 2 P16435 1 +Lipid biosynthetic process 0.4206092581579972 2.644785720153446 0.0081742663053996 1.0 0.0442570424884756 154 Q6IAN0,P54646,Q15392,Q8NBX0,Q01968,O94788,Q9P035,P30536,Q14534,Q16850,O95864,Q9NWU1,Q13510,O76062,Q9NPH0,P52429,Q14849,Q9H7Z7,O15228,Q8NCG7,Q9UBM7,O43292,Q8NF37,P48449,Q86YN1,P16435,Q14739,P48651,Q96G23,Q96N66,Q92643,O95470,Q9BXW6,P04062,O15269,Q8WTV0,Q53GQ0,Q13315,O00116,Q8WVX9,Q5T2R2,Q8NCC3,Q9BTU6,Q06136,O75845,P49327,P42345,Q15800,P11802,O60512,P49748,Q9NUQ2,Q8TBX8,P27544,O00767,P37268,O75592,P54619 58 +Carbohydrate derivative transport 0.7932536843237404 2.642845444211437 0.0082212553579779 1.0 0.0444381199827438 13 Q8WTV0,Q8TB61,P07602,O43808,Q9NZJ7,P05141,P12236,P12235 8 +Chondroitin sulfate proteoglycan biosynthetic process 0.7688898288910113 2.6248773509961527 0.0086680184449099 1.0 0.0454672558237402 3 Q96L58 1 +Chondroitin sulfate proteoglycan metabolic process 0.7688898288910113 2.6248773509961527 0.0086680184449099 1.0 0.0454672558237402 3 Q96L58 1 +Chondroitin sulfate biosynthetic process 0.7688898288910113 2.6248773509961527 0.0086680184449099 1.0 0.0454672558237402 3 Q96L58 1 +Female meiosis i 0.809543193582174 2.6196703927615164 0.0088014790429193 1.0 0.0459817037863457 4 O14777,O95067 2 +Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c 0.7266627771295047 2.619412445486248 0.0088081380157629 1.0 0.0459817037863457 2 Q07812 1 +Cellular response to mineralocorticoid stimulus 0.7676124113714771 2.61862776845622 0.0088284223290677 1.0 0.0460509597164886 3 P20020 1 +Protein localization to endoplasmic reticulum 0.5867488037515541 2.613276500055603 0.0089678717178396 1.0 0.0465015904875175 36 P46379,P24390,O43292,Q9Y5M8,Q15629,O43731,Q9NQC3 7 +Amyloid precursor protein metabolic process 0.6924750637162416 2.613138084636643 0.0089715046566896 1.0 0.0465015904875175 20 Q15392,Q9Y287,O95197,Q9NQX7,Q96P70,Q9NQC3 6 +Nucleotide transmembrane transport 0.8530861369986509 2.609462357096971 0.0090684622657919 1.0 0.0468202908190237 8 Q9BSK2,Q8TB61,O43808,Q9H2D1,P12236,P12235 6 +Positive regulation of protein exit from endoplasmic reticulum 0.8073466267472723 2.609412174711496 0.0090697924152411 1.0 0.0468202908190237 4 Q9NR31,Q9Y6B6 2 +Neuroblast division 0.7656842719579724 2.609185549815647 0.0090758015729652 1.0 0.0468202908190237 3 Q92974,Q96N67 2 +Asymmetric neuroblast division 0.7656842719579724 2.609185549815647 0.0090758015729652 1.0 0.0468202908190237 3 Q92974,Q96N67 2 +Positive regulation of ryanodine sensitive calcium release channel activity 0.7651327033392583 2.606482474718019 0.0091477505074812 1.0 0.0470435257289124 3 P78417 1 +Regulation of sulfur metabolic process 0.7645154012338264 2.6034561984844755 0.0092289059541135 1.0 0.0473866047503074 3 O75027 1 +Autophagy of mitochondrion 0.5991465395840615 2.600845443468054 0.0092994340092342 1.0 0.0475626546910329 33 P42858,P04062,P30536,Q7Z3C6,Q9UBN7,P52789,Q9BWH2,P27544,P21796,Q99623,P12235 11 +Cellular hormone metabolic process 0.7016428578617941 2.5982455186262214 0.0093701470304519 1.0 0.0478497313726268 19 O95470,P42892,Q14849,P30536,Q9HB40 5 +Macromolecule depalmitoylation 0.8358311197409342 2.594866038045677 0.0094627793150925 1.0 0.0481728144807116 5 P50897 1 +Protein depalmitoylation 0.8358311197409342 2.594866038045677 0.0094627793150925 1.0 0.0481728144807116 5 P50897 1 +Glycosylceramide metabolic process 0.803760487013313 2.5926368561054822 0.0095243278779297 1.0 0.0484485577790505 4 P04062,O60512 2 +Glycosylation 0.5457006513697916 2.5918043391470205 0.0095474053888786 1.0 0.0484907694750942 47 O60502,O15118,Q16706,Q10472,Q9Y5P6,P04062,O60512,P46977,Q96L58,Q9H9S5,Q9BT22,O75503,Q86YN1,Q6ZXV5,Q8NAT1,Q8N4A0,O43505,Q2TAA5 18 +Neuronal action potential 0.8341676640023906 2.5873276248658046 0.0096723576884862 1.0 0.0490494676598508 5 P04062 1 +Locomotor rhythm 0.8017346712938902 2.5831452783213686 0.009790408693457 1.0 0.0493809852778363 4 P54802 1 +Positive regulation of dna ligation 0.719369894982489 2.5818274509102217 0.0098278708365229 1.0 0.0494938514422589 2 P09429 1 +T helper 1 type immune response 0.759655298838595 2.579590734848593 0.009891746864465 1.0 0.0497011048427408 3 P42345 1 +T helper 1 cell differentiation 0.759655298838595 2.579590734848593 0.009891746864465 1.0 0.0497011048427408 3 P42345 1 +Regulation of macroautophagy 0.5139373126352647 2.579213220662226 0.0099025643033912 1.0 0.0497173886448761 61 P54646,P42858,Q93050,Q9Y5X3,P09601,P46934,P21796,Q9BQS8,Q15382,Q9UBN7,P12235,P04062,O15269,Q9Y487,P42345,O15118,Q8TBX8,P27544,P05141 19 +Regulation of morphogenesis of a branching structure 0.7973680372097427 2.5626489044425953 0.0103877033522747 1.0 0.0515223804970727 4 Q9Y5V3,Q9NQC3 2 +Lysosomal lumen acidification 0.8285660361949159 2.5618914854674784 0.0104103839781077 1.0 0.0515958758794133 5 Q8N511,P50897 2 +Ether biosynthetic process 0.8283211678832069 2.560777786086718 0.0104438133163491 1.0 0.0516710609403768 5 Q6IAN0,P49327,O15228,O00116 4 +Minus end directed organelle transport along microtubule 0.714994165694284 2.5591931103832257 0.0104915443383422 1.0 0.0518024935652382 2 Q14204 1 +Cytochrome complex assembly 0.7949912591529961 2.558428109322461 0.0105146558338442 1.0 0.051877572617809 12 Q7KZN9,Q9BSK2,Q69YU5,Q9Y2R0,Q15070,P47985 6 +Retina morphogenesis in camera type eye 0.7959719789842226 2.5560852251735957 0.0105857188528415 1.0 0.0521889459897417 4 P54802,Q16706,Q15555 3 +Localization within membrane 0.3915289457656978 2.555393968608612 0.0106067671016356 1.0 0.0522534577484483 191 P35613,Q9HD45,Q9NS69,Q13277,Q9HD20,O60725,Q9H4A6,Q13641,O43805,P17931,Q9P0J0,P43307,O75955,P57105,O15400,Q9Y512,Q9Y5J9,Q15041,O76094,Q15904,P0DP25,P49354,Q15057,Q9H223,O43681,Q9Y584,Q96A33,O14737,Q9Y5L4,P07602,Q99959,Q7L5D6,O00264,Q15629,O15118,Q9BTX1,O00203,Q15907,Q15363,Q96KP1,Q9NZJ7,Q07812,P50570,P46379,Q9NPA0,Q15070 46 +Dendritic cell differentiation 0.7952406413005808 2.552644696151714 0.0106908492776234 1.0 0.052549328059749 4 P09429,P01889 2 +Alcohol metabolic process 0.4813374462648604 2.548076989426376 0.010831856310193 1.0 0.0530437620205123 87 P54646,Q15392,Q9BQE5,Q14534,Q16850,Q13510,O76062,Q14849,Q06520,P00374,P48449,P16435,Q14739,P04062,Q8WTV0,P51648,P05067,O15118,Q15800,P49748,P37268 21 +Glycoprotein biosynthetic process 0.5196274468848923 2.5464601694248765 0.0108821629551241 1.0 0.0532503753255216 55 Q9H4A6,Q9H9S5,Q8NAT1,Q8N4A0,Q2TAA5,Q16706,Q9Y287,Q9UL01,Q7LGA3,Q86YN1,Q10472,Q9Y5P6,Q9NQX7,Q6ZXV5,O60502,O15118,O60512,P46977,Q96L58,Q9BT22,O43505 21 +Dna methylation involved in gamete generation 0.7528450539830446 2.5460318406385465 0.0108955249626834 1.0 0.0532760318965191 3 Q8N2A8,Q8NB78 2 +Atp transport 0.8248409426176524 2.54493294361352 0.0109298725188125 1.0 0.0532851585946862 5 P12235,P12236,O43808 3 +Cerebellar purkinje cell layer development 0.8476189820719302 2.5439931212963818 0.0109593242773256 1.0 0.0533494702580197 7 O14949,P04062 2 +Glycerophospholipid catabolic process 0.8382735700285905 2.542223770883357 0.0110149628568048 1.0 0.0535485029592622 8 Q8WTV0 1 +Calcium import into the mitochondrion 0.8236602840358775 2.5395507198714076 0.011099495018606 1.0 0.0539118329475152 5 Q8IYU8,P21796 2 +Cellular lipid metabolic process 0.3907915516461189 2.532519738503268 0.0113245993669999 1.0 0.0545448521858642 221 Q6IAN0,P54646,Q8NBX0,Q9P035,P06280,O95864,Q8N4Q0,P07099,Q2TAA5,Q16134,Q13510,P16278,Q9NPH0,P52429,O15228,Q9H7Z7,A8MXV4,Q8NCG7,O43292,P50897,Q8NF37,Q9HB40,P43034,P48449,Q86YN1,P16435,P48651,Q96G23,Q96N66,P23786,O95470,Q8IXJ6,P04062,A1L0T0,Q8WTV0,O15269,Q53GQ0,Q13315,P07602,O00116,P51648,O75844,Q8NCC3,Q9BTU6,Q06136,Q99623,Q15067,P49327,O14678,Q16836,Q15800,O60512,P17900,P49748,Q9NUQ2,Q8TBX8,Q07812,P27544,O43808,Q9NZJ7,Q9BT22,O00767,Q8NHP8,Q6NUM9,Q9UJZ1,P37268 66 +Ceramide transport 0.8206362161823315 2.525749059172744 0.0115451914585738 1.0 0.0551431606531158 5 Q9NZJ7,P07602 2 +Meiotic spindle assembly 0.8204659290759064 2.524971196124062 0.0115707772551041 1.0 0.0552199566167224 5 O14777,O95067 2 +Detection of biotic stimulus 0.8196616845857669 2.5212964623167986 0.0116923296595627 1.0 0.0556381923321617 5 P30536 1 +Calcium ion export 0.818692257789361 2.516864820267668 0.0118404247904082 1.0 0.0561943651435153 5 O95202,P20020 2 +Immunological synapse formation 0.7068261376896123 2.5167744070894815 0.0118434634247914 1.0 0.0561943651435153 2 P17931 1 +Regulation of protein lipidation 0.7856986830639222 2.5076234635515946 0.0121546111204651 1.0 0.0574629381646196 4 P04062 1 +Mitochondrial electron transport ubiquinol to cytochrome c 0.8153136292741849 2.501401261495374 0.0123702931456026 1.0 0.0579399454828299 5 O14949,Q9UDW1 2 +Walking behavior 0.8466017672630333 2.501142882760953 0.0123793222586883 1.0 0.0579408792164855 6 O75844,O15118 2 +Positive regulation of toll like receptor signaling pathway 0.7825604129255257 2.4927627621146353 0.012675350499018 1.0 0.0591094256528406 4 P09429,Q9NQC3 2 +Central nervous system projection neuron axonogenesis 0.7420484388678058 2.4925475604906016 0.0126830343369703 1.0 0.0591094256528406 3 P43034,O75592 2 +Regulation of mitochondrion organization 0.5336522256577999 2.4900477377461905 0.0127725938290916 1.0 0.0593581874691923 47 Q8N2A8,P42858,Q8NE86,Q9Y6C9,O14737,P30536,Q9H4A6,Q9UBN7,Q07812,P27544,P21796,Q9NUQ9,Q96A26,P12235,Q99536,O14965 16 +Glycosaminoglycan catabolic process 0.8127179107795259 2.4895014540014526 0.0127922395286552 1.0 0.0593654001322743 5 P16278 1 +Aminoglycan catabolic process 0.8127179107795259 2.4895014540014526 0.0127922395286552 1.0 0.0593654001322743 5 P16278 1 +Eye photoreceptor cell development 0.7806422569193381 2.4836665944170258 0.0130037493481416 1.0 0.0602191977575902 4 P54802,Q15555 2 +Plus end directed organelle transport along microtubule 0.7399982341063206 2.482352088321313 0.0130518241228891 1.0 0.06039920302849 3 Q9BQS8 1 +Regulation of vasoconstriction 0.7395775731750169 2.480258632912812 0.0131287115777902 1.0 0.060627755388984 3 P42892 1 +Regulation of response to extracellular stimulus 0.7794204596640114 2.4778674752855965 0.0132170226904311 1.0 0.0609292900329263 4 P80303 1 +Tetrapyrrole metabolic process 0.662076006295011 2.4777308865790504 0.0132220830549965 1.0 0.0609292900329263 21 P30519,O14678,P30536,P09601,O00264 5 +Regulation of heart rate by chemical signal 0.6992415402567143 2.4771890448240024 0.0132421741918113 1.0 0.0609790505590641 2 P09493 1 +Regulation of nervous system process 0.7409400346248686 2.4710926097626515 0.0134700930373157 1.0 0.0619416611849094 14 P04062,Q9UQB8 2 +Cellular response to leucine starvation 0.7371811895147166 2.468322756416163 0.0135747860010777 1.0 0.0622485993983733 3 P42345 1 +Mitochondrial cytochrome c oxidase assembly 0.8078206129039891 2.467004005509972 0.0136248833464274 1.0 0.0622693776812846 5 Q9Y2R0 1 +Positive regulation of isotype switching to igg isotypes 0.6954492415402582 2.457325150763576 0.0139975931327029 1.0 0.0638305810540632 2 Q96QE3 1 +Retinal metabolic process 0.7338780274292328 2.451842312470113 0.0142126930122541 1.0 0.0645870440072103 3 O94788,Q8NBN7 2 +Regulation of morphogenesis of an epithelium 0.7330204843938288 2.4475584493236706 0.0143827794863822 1.0 0.0651794191917404 3 Q9Y5V3 1 +Respiratory chain complex iii assembly 0.8320246894700875 2.4362181425264757 0.0148417310352397 1.0 0.0668612945888621 6 Q69YU5,Q9BSK2,P47985 3 +Cellular homeostasis 0.4095375659863194 2.4360929394781095 0.0148468693160301 1.0 0.0668612945888621 150 P54646,P42858,Q9NUT2,Q15120,Q93050,Q9HD20,P55011,Q07820,P09601,P20020,O95202,O14617,P06576,Q8N511,Q15043,O43819,Q9UM00,Q8NE86,Q15904,P0DP25,P32119,P50897,Q9BWH2,Q6YHU6,Q96A33,P09429,P13473,P14735,Q00535,Q9P2D1,Q4KMQ2,Q8N5M9,Q9H1E3,O76024,Q16763,Q9Y6M7,Q9Y487,P10253,P05067,P78417,P52789,O00203,Q15907,Q07812,Q9UJZ1,O75503,Q92544,O75027,P16615,Q8IYU8,Q9NQC3 51 +Response to ph 0.8010661110961279 2.4358753894739755 0.0148558012055106 1.0 0.0668612945888621 5 Q15907,P04062 2 +Negative regulation of gliogenesis 0.829743203540696 2.426011151828343 0.0152658011793538 1.0 0.0682359425165257 6 P30536 1 +Glycerol ether metabolic process 0.8285630841121541 2.4207266507372083 0.0154895198648381 1.0 0.0690035501378601 6 Q6IAN0,P49327,O15228,O00116,P43034 5 +Endomembrane system organization 0.3837136968025004 2.419021617447761 0.0155623153355117 1.0 0.0692395595159507 174 Q9Y3B3,P42858,Q13277,O75165,Q86XL3,Q2M389,Q9H4A6,Q14108,Q8TBA6,Q8NHH9,O75955,Q15041,Q9BVK6,O95197,Q13190,Q96GC9,P43034,O43681,P49755,Q96A33,Q8IXJ6,P61020,Q8NFQ8,Q9H5V9,O15260,P06493,Q7Z3C6,O94901,Q4KMQ2,O75844,Q8N5M9,Q9BTU6,P48729,Q7L5D6,Q15629,Q9UQB8,Q14789,P57088,P16615,Q9P2W9,Q12907,Q15363,P50570,P46379,Q9NPA0,Q9BTV4,Q9NQC3 47 +Negative regulation of cellular amine metabolic process 0.6881563593932372 2.4189915655562144 0.0155636010798578 1.0 0.0692395595159507 2 O14874 1 +Lipid homeostasis 0.6024973537675441 2.416334218402225 0.0156776636018853 1.0 0.0695672466687505 27 P54646,Q15067,O15118,O15260,Q9Y6C9,Q9Y6B6,Q8WTV0,P28340,Q9NQC3,Q5BJF2 10 +Fatty acid transmembrane transport 0.8188895169423688 2.4141738426837156 0.0157709356993502 1.0 0.069830553346246 7 O43772,P23786 2 +Regulation of blood pressure 0.6701694586138529 2.4135162541433615 0.0157994231651081 1.0 0.0698951607024374 19 P42892,Q9Y5X3,Q9UIQ6,P42785,P09601,P20020,Q9HB40 7 +Modulation of excitatory postsynaptic potential 0.7961929761995568 2.413345449707096 0.0158068300034162 1.0 0.0698951607024374 5 Q9UQB8 1 +Glutamate receptor signaling pathway 0.7647924242863848 2.4081232293930905 0.0160347676302237 1.0 0.0707600169398305 4 P05067,Q8NCG7 2 +Positive regulation of atpase coupled calcium transmembrane transporter activity 0.6855309218203002 2.405148309697637 0.0161659036200791 1.0 0.071290765829946 2 Q96GC9 1 +Regulation of presynaptic cytosolic calcium ion concentration 0.7231677130765406 2.398180966602504 0.0164767227023392 1.0 0.0723696481745315 3 P20020 1 +Negative regulation of glycoprotein metabolic process 0.7626529598694985 2.397873911239816 0.0164905406587139 1.0 0.072381891506676 4 Q9Y287 1 +Intermembrane lipid transfer 0.8061467797188683 2.394510880714297 0.0166425496498325 1.0 0.0729028109494001 8 P30536 1 +Kidney morphogenesis 0.7919149437380478 2.3935171982194725 0.0166876989583877 1.0 0.0729059124933024 5 O75844 1 +Leukocyte differentiation 0.4756148346239954 2.391332542907578 0.0167873400403621 1.0 0.073049419989958 71 Q6IAN0,Q13546,P24390,P01889,Q5HYI8,P17931,P55327,P09874,Q15904,P32119,Q14739,O96005,O15360,P09429,P04062,Q13315,Q9P2D1,Q8N5M9,P05067,P49327,P42345,P78527,O00203,Q07812,P05141 25 +Intracellular lipid transport 0.7257473376687866 2.390628172871512 0.0168195771752819 1.0 0.0731411964375083 14 O43772,O15118,P23786 3 +Endoplasmic reticulum to golgi vesicle mediated transport 0.4869341828195453 2.387656152230162 0.0169561977552923 1.0 0.0735890011046483 65 O95249,Q9Y3B3,P24390,Q6NUQ1,Q9Y678,P62820,Q8NHH9,Q9BVK6,Q9Y6B6,Q9HCU5,Q13190,O43731,P49755,O95487,Q9H5V9,P61019,Q9Y282,P18085,Q96PC5,O15498,Q9P2W9,Q12907,Q15363,Q9NR31 24 +Negative regulation of amyloid precursor protein catabolic process 0.8128362940767041 2.3865648506411374 0.0170066076252635 1.0 0.0735984325607885 7 O95197,Q9NQC3 2 +Regulation of lysosomal lumen ph 0.8194554958719347 2.379832256332894 0.0173205205524125 1.0 0.0741888093113126 6 Q8N511,P50897 2 +Intracellular transport 0.3351459664264266 2.377933193878051 0.0174099798222528 1.0 0.0743777914020986 594 P55060,Q9NS69,P24390,O75165,P30536,P45880,Q2M389,P46934,Q14108,P43307,Q8N4H5,O60830,P06576,O75964,O15400,Q14849,O76094,O75381,Q9Y5X2,Q9UBX3,Q99595,P43034,O43731,O95487,Q9Y584,P23786,Q96N67,Q9H5V9,Q4KMP7,P06493,P07602,O95071,O94901,Q00535,O75844,Q9Y282,Q03518,Q15629,O15118,Q9P2W9,Q15907,P10619,O75503,P46379,O14925,Q15070,P55786,Q9Y3B3,Q7Z4Q2,O60725,Q9P0J0,O43772,P52292,P57105,Q96P70,Q9Y5M8,P24539,P12235,Q5T9L3,Q03519,P13473,Q9Y5L4,Q969Q5,P53367,Q8NBN3,Q9BUN8,Q96PC5,P05067,O14678,P52789,Q15363,Q9NZJ7,Q9NR31,P16615,O95249,P42858,Q13277,Q5HYI8,Q9Y5X3,Q8TCT9,P62841,Q96RL7,Q9Y6B6,Q13190,Q15057,Q9H223,P49755,A0AVF1,O15260,O14737,Q658Y4,A4D1P6,O15397,Q8TB36,Q15388,Q96D46,Q9UBK9,Q07812,Q99797,Q99623,O95391,Q15154,O43805,Q9BQS8,P11279,Q8NHH9,Q9C0E2,Q9Y512,Q9Y5J9,Q15041,Q9BVK6,Q92974,O95613,Q15904,Q9UBN7,Q96QU8,O43681,P61020,P56385,Q92973,Q13409,Q7L5D6,P18085,P61970,Q12907,O00203,P05141,Q9UJZ1 128 +Bicarbonate transport 0.6799883313885617 2.37584849732372 0.0175086500275503 1.0 0.0745969395791277 2 Q9Y6M7 1 +Nucleotide transport 0.7839494954072836 2.3729956245865504 0.0176444729371501 1.0 0.0749124387857101 10 Q9BSK2,Q8TB61,O43808,Q9H2D1,P12236,P12235 6 +Glycoside catabolic process 0.8179148024957809 2.3728948330579676 0.0176492883820036 1.0 0.0749124387857101 6 Q9BTY2,P04062,Q9NUJ1 3 +Pigment metabolic process 0.6047420313847097 2.372295409759999 0.0176779504029527 1.0 0.0749855918191181 26 P30519,P30536,P09601,O00264,Q7KZN9 5 +Endoplasmic reticulum membrane organization 0.801038216662675 2.370783833632323 0.0177504091343403 1.0 0.0751957293347587 8 Q8NHH9,Q15041,Q9P2W9,Q15363,Q9NQC3 5 +Response to aldosterone 0.7169536037350386 2.36688913159081 0.0179383055591033 1.0 0.0758448202827553 3 P09874,O95831 2 +Ceramide biosynthetic process 0.7817341030205742 2.3623382456925457 0.0181600644815962 1.0 0.0765295257003843 10 Q13510,P04062,Q96G23,O60512 4 +Signal peptide processing 0.7852013418746129 2.362306625586971 0.018161613649845 1.0 0.0765295257003843 5 P67812,O75503 2 +Positive regulation of macroautophagy 0.6191330816380894 2.357311374643922 0.0184078045046143 1.0 0.0769866240658248 24 P54646,P42858,O15269,Q8TBX8,P09601,P27544,P21796,Q9BQS8,P12235 9 +Fatty acid homeostasis 0.754019646968897 2.3563886764474415 0.0184535979051414 1.0 0.0771054166115471 4 P28340 1 +Cellular ion homeostasis 0.4635507147819066 2.3560293307791795 0.0184714591455885 1.0 0.0771054166115471 87 P42858,Q93050,Q9HD20,P55011,P09601,P20020,O95202,O14617,P06576,Q8N511,Q15043,O43819,Q9UM00,Q8NE86,Q15904,P0DP25,P50897,Q6YHU6,Q96A33,P09429,Q00535,Q9P2D1,O76024,Q9Y6M7,Q9Y487,P05067,P78417,O00203,Q07812,Q9UJZ1,O75503,Q92544,O75027,P16615,Q8IYU8 35 +Membrane lipid catabolic process 0.7368370811201493 2.355146858339496 0.0185153865652096 1.0 0.0771415661212101 13 O95470,P50897,P04062,P17900 4 +Nadh dehydrogenase complex assembly 0.5847462956885477 2.35465443233911 0.0185399380998936 1.0 0.0771948437890241 28 Q9P032,Q96CU9,P03886,P51970,Q9Y6M9,Q9P0J0,O43676,Q9H061,Q86Y39,Q15070 10 +Regulation of mitochondrial fusion 0.7833576642335462 2.3537155822841314 0.0185868265355448 1.0 0.0772919871522468 5 Q8N2A8,Q99536,Q7Z6Z7,Q9Y6C9 4 +O glycan processing 0.7823270196442331 2.3489092881648728 0.0188284932430151 1.0 0.0781483698043425 5 Q8N4A0,O43505 2 +Positive regulation of chemokine production 0.8044690389713655 2.3482538904213413 0.0188616595092057 1.0 0.078188011799838 7 P05067,P09601 2 +Lipoprotein metabolic process 0.6408083643596986 2.346645337222946 0.0189432766834369 1.0 0.0784411360505263 21 P04062,Q5HYI8,Q9BQE5,Q9NUJ1,O43292,P50897 6 +Ph reduction 0.7344169300030762 2.342586547821023 0.0191505917727596 1.0 0.0791584157200046 13 Q8N511,Q9Y487,O75503,P50897 4 +Dna dealkylation involved in dna repair 0.6726954492415256 2.337140526963763 0.0194318783489486 1.0 0.0800954684207293 2 Q8N3C0 1 +Regeneration 0.5589747605229485 2.335830033397172 0.0195001016625311 1.0 0.0801767802785657 34 P30536,P09601,P00374,Q7Z4V5,P31939,Q96G23 6 +Protein localization to membrane raft 0.6724037339556462 2.335588528030205 0.0195126970595655 1.0 0.0801767802785657 2 O75955 1 +Toll like receptor 3 signaling pathway 0.6724037339556462 2.335588528030205 0.0195126970595655 1.0 0.0801767802785657 2 O75955 1 +Regulation of toll like receptor 3 signaling pathway 0.6724037339556462 2.335588528030205 0.0195126970595655 1.0 0.0801767802785657 2 O75955 1 +Lipoprotein localization 0.7918223476361669 2.3278136672314003 0.0199220000342155 1.0 0.0815087318993219 8 Q9Y6B6,Q13432,A6NIH7 3 +Magnesium ion transport 0.6703617269544955 2.324716606382908 0.020087118715264 1.0 0.0819856591801723 2 Q6P4Q7 1 +Protein o linked mannosylation 0.7769618570547933 2.323845814934628 0.0201337592367054 1.0 0.0820459383301158 5 Q9H9S5,O43505,Q6ZXV5 3 +Protein mannosylation 0.7769618570547933 2.323845814934628 0.0201337592367054 1.0 0.0820459383301158 5 Q9H9S5,O43505,Q6ZXV5 3 +Proton transmembrane transport 0.5301797607008945 2.323680199726386 0.0201426404525779 1.0 0.0820459383301158 40 O75964,P56385,Q7KZN9,Q13423,P14854,P13073,Q9UJZ1,P00403,P05141,Q99623,P24539,Q96ES6,P12235,Q9UDW1,P47985 15 +Sterol transport 0.5974600979463693 2.322882158439382 0.0201854838428188 1.0 0.0820536299416131 26 Q14849,P30536,Q8WTV0 3 +Behavioral response to pain 0.7081062638023589 2.32213732297226 0.0202255425615338 1.0 0.0820536299416131 3 P30536 1 +Response to pain 0.7081062638023589 2.32213732297226 0.0202255425615338 1.0 0.0820536299416131 3 P30536 1 +Positive regulation of mitochondrion organization 0.6214374846202677 2.320682069734674 0.0203040091379818 1.0 0.0820536299416131 23 Q8N2A8,P42858,Q8NE86,O14737,Q07812,P27544,P21796,Q96A26,P12235,O14965 10 +Negative regulation of lipase activity 0.7054484993297128 2.3086478221182256 0.0209631319435423 1.0 0.0835723401054222 3 P16435 1 +Porphyrin containing compound metabolic process 0.6720442667042786 2.3026661994222506 0.0212976313550132 1.0 0.084263805695939 17 O00264,P30519,P30536,P09601 4 +Iron ion transport 0.7779009804795327 2.301925824121902 0.0213393556053631 1.0 0.084303944300056 9 Q9H9B4,Q15907,P50570,O15173,O75027,Q15043 6 +Amyloid precursor protein catabolic process 0.6906134906524499 2.298057985814265 0.0215584890746822 1.0 0.0850672310932441 15 Q96P70,Q15392,O95197,Q9NQC3 4 +Prenylation 0.7416054952667661 2.2963797740012484 0.0216541764113702 1.0 0.0853874354897447 4 P49356 1 +Aminoglycan metabolic process 0.6901943122737632 2.295732716782346 0.0216911685828533 1.0 0.0853874354897447 15 Q96L58,P54802,P16278,Q7LGA3 4 +Response to progesterone 0.7709571310417834 2.2957077400313146 0.0216925976021427 1.0 0.0853874354897447 5 P30536 1 +Negative regulation of nitric oxide metabolic process 0.7707197914067433 2.2945936840602705 0.0217564205707501 1.0 0.0855396235981199 5 P30536 1 +Response to muscle activity 0.770256734769579 2.292419715245725 0.0218814354442777 1.0 0.0859281743778281 5 P54646,Q9UDX5 2 +Semaphorin plexin signaling pathway involved in neuron projection guidance 0.7020134454343847 2.2911817339123512 0.0219529049605819 1.0 0.086012283165186 3 P42892 1 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.7020116500271805 2.2911725956013185 0.0219534332757982 1.0 0.086012283165186 3 P01889 1 +Transferrin transport 0.7699843331836008 2.291140583155728 0.0219552841057126 1.0 0.086012283165186 5 Q15907,P50570 2 +Mammary gland epithelial cell proliferation 0.7991458478626873 2.287928616402216 0.0221416785046779 1.0 0.0866390544708985 6 Q07812,Q9NQC3 2 +Intracellular protein transport 0.3481000301415595 2.285635625845512 0.0222755841622059 1.0 0.0871110746557781 343 P55786,Q15154,Q9NS69,Q9Y3B3,Q7Z4Q2,Q13277,Q5HYI8,P30536,O60725,Q9Y5X3,Q8TCT9,Q9P0J0,Q14108,P43307,Q8N4H5,O60830,P52292,P57105,Q9C0E2,Q9Y512,Q96RL7,Q9Y5J9,Q15041,Q9BVK6,Q9Y6B6,Q92974,O95613,Q15904,Q13190,Q9UBN7,Q96P70,Q96QU8,Q9Y5M8,Q99595,O43681,P49755,Q9Y584,Q5T9L3,P61020,P13473,O15260,O14737,Q92973,Q9Y5L4,Q969Q5,Q658Y4,P53367,O15397,Q9Y282,Q7L5D6,Q9BUN8,Q15629,P18085,Q8TB36,Q15388,Q9P2W9,Q15363,P10619,Q07812,Q99797,Q99623,Q9NR31,P46379,O14925,O95391,Q15070 66 +Peptidyl glutamic acid modification 0.7683561146372473 2.283490924005364 0.0224014668717604 1.0 0.0872222729446189 5 P38435,Q8N0U8 2 +Lysosomal protein catabolic process 0.7817666727311569 2.280683153801794 0.0225672027337908 1.0 0.0875730244465616 8 Q8N511,P04062,P13473,O14773 4 +Protein catabolic process in the vacuole 0.7817666727311569 2.280683153801794 0.0225672027337908 1.0 0.0875730244465616 8 Q8N511,P04062,P13473,O14773 4 +Respiratory chain complex iv assembly 0.7973081736495631 2.2795644689340246 0.0226335322916582 1.0 0.0877785099869155 6 Q9Y2R0,Q15070 2 +Dttp metabolic process 0.6974583838785886 2.267966100185787 0.0233312729456005 1.0 0.089689404258366 3 Q9H773 1 +Plasma membrane to endosome transport 0.7356108680185577 2.2672519223559715 0.0233748406178897 1.0 0.0898042764254054 4 P61020 1 +Alcohol biosynthetic process 0.5366004879246976 2.263103693583385 0.0236292979272501 1.0 0.0905697739477892 37 P54646,Q13510,Q15392,O76062,P04062,O15269,Q15800,Q9UBM7,Q16850,P00374,P48449,P16435,Q14739,P37268 14 +Lipopolysaccharide mediated signaling pathway 0.7690202522584595 2.2594973169341435 0.0238524670178583 1.0 0.0911605693680585 9 Q86UE4,Q8WTV0 2 +Peptidyl serine modification 0.4582737961694957 2.257801315632181 0.0239580491713504 1.0 0.0911605693680585 81 P54646,Q13546,Q15120,P51812,Q8N4A0,P09874,Q9UGN5,Q9UBN7,Q96N67,Q10472,P06493,Q13315,Q00535,P48729,Q15418,O14965,Q9H7B4,P05067,P42345,Q14149,Q13535,P78527,Q07812,Q96GX5 24 +Outer mitochondrial membrane organization 0.7628074199020584 2.257371506501629 0.02398487061503 1.0 0.0911605693680585 5 O14737,Q9NS69 2 +Mitochondrion distribution 0.7626973388721415 2.256852528749552 0.02401729116171 1.0 0.0911605693680585 5 O75153,Q9BUK6 2 +Negative regulation of natural killer cell mediated immunity 0.7333517558510064 2.2562495123995756 0.0240550093250966 1.0 0.0912421798793549 4 P04439,P01889 2 +Regulation of leukocyte degranulation 0.7916998783548327 2.2539886839309986 0.0241968798787877 1.0 0.0916965800147129 6 P09601 1 +Aminoglycan biosynthetic process 0.7749345164821504 2.248515420024137 0.0245433429492347 1.0 0.0926108544695028 8 Q96L58,O43505,Q7LGA3 3 +Neuron remodeling 0.6936095710533674 2.2483013992003675 0.0245569775642997 1.0 0.0926108544695028 3 P05067,O94887 2 +Negative regulation of autophagy 0.6021047400349733 2.2453662540693338 0.0247446299347322 1.0 0.0931579240572077 24 P09601,O15118,P30536 3 +Acute inflammatory response 0.7585665475549335 2.2373556105628567 0.0252631072966471 1.0 0.0946212957081042 5 Q9BQE5 1 +Glycosphingolipid metabolic process 0.7552007453185611 2.2336718188412985 0.0255046745662022 1.0 0.0951329377055589 10 P04062,P16278,O60512,P17900,Q07812 5 +Skeletal muscle contraction 0.7285932024959177 2.2330287690804984 0.0255470472565026 1.0 0.0951417276374408 4 P78417 1 +Liposaccharide metabolic process 0.6496369650952423 2.229911000745551 0.0257533519319346 1.0 0.0957856386268644 18 P04062,P16278,O60512,P17900,Q8NBX0,Q07812,O43292 7 +Positive regulation of mast cell activation involved in immune response 0.6522753792298762 2.227816754440191 0.0258927371271247 1.0 0.096100943631081 2 O95219 1 +Vacuolar acidification 0.7539584174599516 2.22760109946708 0.0259071272909756 1.0 0.096100943631081 10 Q8N511,Q9Y487,O75503,P50897 4 +Mucopolysaccharide metabolic process 0.7702321163464902 2.2263067123978764 0.0259936441788684 1.0 0.0963673972326183 8 Q9UL01,Q96L58,P16278,O43505 4 +Cytosolic calcium ion transport 0.5832444016155132 2.225626819952328 0.0260391881983235 1.0 0.0964734481065955 26 P42858,P78417,Q8IYU8,Q9P2D1,P0DP25,Q07812,P21796,P20020,P16615,O95202 10 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.727040979057433 2.2254409145327982 0.0260516534661516 1.0 0.0964734481065955 4 Q03518 1 +Mononuclear cell differentiation 0.4951330195520659 2.224261774570256 0.0261308369492179 1.0 0.0966575828978399 50 P55327,P49327,P42345,P09429,P24390,P04062,P01889,Q5HYI8,Q13315,P78527,Q9P2D1,O00203,P32119,Q07812,P05141,O96005,O15360 17 +Retina homeostasis 0.6886489641085318 2.222890628828998 0.0262231758368665 1.0 0.0968603717593021 3 P11166,Q15555 2 +Organic cation transport 0.7261468699429873 2.221067196695265 0.0263464104349648 1.0 0.0968603717593021 4 O43772,Q70HW3 2 +Glycoprotein metabolic process 0.474512355220069 2.2173749546778185 0.0265974797184262 1.0 0.0975042803979404 62 Q9H4A6,Q9H9S5,Q8NAT1,Q8N4A0,Q2TAA5,P62820,Q16706,Q9Y287,Q9UL01,Q7LGA3,Q86YN1,Q92542,Q10472,Q9Y5P6,Q9NQX7,Q6ZXV5,O60502,O15118,O60512,P46977,Q96L58,Q9BT22,O43505,O60476 24 +Transepithelial transport 0.7537469248807045 2.214552656876737 0.0267907846321671 1.0 0.0981033084577458 5 P55011,P51798,P08183 3 +T cell differentiation 0.5730014935860812 2.2115529853618203 0.0269975669800788 1.0 0.0987370708008991 27 P42345,P09429,P24390,P04062,Q5HYI8,P78527,Q9P2D1,P32119,O96005,O15360 10 +Tetrahydrofolate biosynthetic process 0.7530789748502094 2.2113877475911696 0.0270089975750706 1.0 0.0987370708008991 5 P00374 1 +Folic acid containing compound biosynthetic process 0.7530789748502094 2.2113877475911696 0.0270089975750706 1.0 0.0987370708008991 5 P00374 1 +Regulation of cellular ph 0.6188451842027218 2.2092029049749033 0.0271605309324181 1.0 0.0991253637255437 21 Q8N511,O75503,Q9Y487,P50897 4 +Regulation of ph 0.6188451842027218 2.2092029049749033 0.0271605309324181 1.0 0.0991253637255437 21 Q8N511,O75503,Q9Y487,P50897 4 +Regulation of atpase coupled calcium transmembrane transporter activity 0.6857309600233237 2.2079086421913305 0.027250642284275 1.0 0.0993989520119028 3 Q96GC9,Q6YHU6 2 +Regulation of oxidoreductase activity 0.6554313653186099 2.2063815558423814 0.0273572953437106 1.0 0.0997325400252385 17 Q8WTV0,P06280,P0DP25,Q8TCT9,P00374,P16435,Q15070,Q99623 8 +Protein transmembrane transport 0.5878603367809911 2.202487562423165 0.0276308867345445 1.0 0.1003952817010415 25 Q9NS69,O60830,Q99595,Q15629,Q9Y584 5 +Positive regulation of autophagy 0.5409831897936449 2.1989012682558124 0.0278849434255237 1.0 0.1010508810737987 34 P54646,P42858,P09429,Q86UE4,O15269,Q8TBX8,P09601,P27544,P21796,Q9BQS8,P12235 11 +Regulation of smooth muscle cell chemotaxis 0.6467327887981392 2.197903982221635 0.0279559490703549 1.0 0.1010726930025724 2 O94813 1 +Smooth muscle cell chemotaxis 0.6467327887981392 2.197903982221635 0.0279559490703549 1.0 0.1010726930025724 2 O94813 1 +Lipoprotein catabolic process 0.7790651484182041 2.1960957478943612 0.0280850908804362 1.0 0.1014836819148801 6 P50897,Q9NUJ1 2 +Response to iron ii ion 0.6817599173585248 2.1874790381701525 0.0287075718242115 1.0 0.1028831711144054 3 Q14457 1 +Establishment of protein localization to organelle 0.3679108139578483 2.1819228404263584 0.0291152278307951 1.0 0.1037640957003218 186 P55786,P55060,Q9NS69,Q7Z4Q2,P30536,P46934,Q9P0J0,Q14108,P52292,Q8N4H5,O60830,P11279,Q9Y512,Q96RL7,Q9Y5J9,O76094,O75381,Q96P70,P0DP25,Q9Y5M8,Q99595,O43681,Q9Y584,P13473,O14737,Q92973,P06493,O95071,Q9Y5L4,O15397,Q7L5D6,Q15629,Q8TB36,P61970,Q15388,P52789,O00203,Q07812,Q99797,Q99623,P46379,O14925,Q15070 43 +Determination of adult lifespan 0.76854104193265 2.1818016675527474 0.0291241734633944 1.0 0.1037640957003218 7 O75844,P14735,P04062 3 +Spontaneous synaptic transmission 0.6806497291334064 2.181759073553241 0.029127318543126 1.0 0.1037640957003218 3 P05067 1 +Regulation of spontaneous synaptic transmission 0.6806497291334064 2.181759073553241 0.029127318543126 1.0 0.1037640957003218 3 P05067 1 +Macroautophagy 0.4233912641076077 2.1799304279238343 0.0292626190303038 1.0 0.1040202091423908 113 P54646,P42858,Q93050,Q9Y5X3,P46934,P09601,P21796,Q9BQS8,Q96HY6,P42574,P62820,Q15382,Q7Z6Z7,Q9Y5W7,Q9UBN7,Q96GC9,P12235,Q86Y82,P04062,P13473,Q9UPT5,O15269,Q7Z3C6,Q00535,Q9Y487,O15118,P42345,P50851,Q8TBX8,P27544,Q9Y5K8,P05141,Q99623,P16615 34 +Chloride transmembrane transport 0.7749261952262252 2.177048420421249 0.0294769548932871 1.0 0.1042658079982897 6 P55011,P51798,Q9UHG3 3 +Monovalent inorganic cation homeostasis 0.5595007332502901 2.174921853404184 0.0296359729758366 1.0 0.1046669831364047 28 Q8N511,Q93050,P55011,Q9Y5X3,Q15904,O75503,P50897,Q9Y6M7,Q9Y487,P06576 10 +Cerebellar cortex development 0.7185621759730325 2.1738368562087507 0.0297173895382714 1.0 0.1048980689349849 12 O14949,P04062 2 +Excretion 0.7445627478797889 2.1709366042573364 0.0299359648847039 1.0 0.1053861596423966 5 P09601 1 +Acylglycerol homeostasis 0.7147455407145453 2.165104876779105 0.0303796545957311 1.0 0.1064910755647369 4 Q8WTV0 1 +Regulation of dna primase activity 0.7430108978132733 2.163545697089787 0.0304992329891877 1.0 0.1067672797332452 5 Q9Y248,Q14691 2 +Purine containing compound transmembrane transport 0.7645139014493654 2.1629472983693505 0.0305452333060896 1.0 0.1068431881420895 7 Q8TB61,P12236,O43808,P12235 4 +Calcium ion import 0.699596405535031 2.15986433169369 0.0307831736940589 1.0 0.1074463754151141 13 Q8NE86,O75844,P17931,P21796,P16615,Q8IYU8 6 +Neuron projection regeneration 0.7315542455318899 2.159147985152522 0.030838687922015 1.0 0.1075829187369818 11 P30536,P00374 2 +Negative regulation of blood pressure 0.7409922651777723 2.1539225575277547 0.0312462456261952 1.0 0.1086827754025482 5 Q9HB40,P42785 2 +Cellular macromolecule localization 0.3264170522592191 2.1538321561259437 0.0312533369680902 1.0 0.1086827754025482 587 P55060,Q9NS69,P24390,P30536,Q13641,P46934,P17931,Q13426,Q14108,P43307,Q8N4H5,O60830,O75955,O15400,P09874,O76094,O75381,Q15555,Q9Y5X2,Q99595,P20337,O43731,O95487,Q9Y584,Q92643,P06493,O95071,O94901,Q00535,Q5JRX3,Q9Y282,Q15629,Q15554,Q14789,O75190,O15118,Q14149,P50402,Q9P2W9,P50851,O14773,Q99523,Q15907,P10619,Q9Y5K8,P46379,O14925,Q15070,Q9NQC3,P55786,Q9HD45,Q9Y3B3,Q7Z4Q2,Q9HD20,O60725,Q9P0J0,P52292,Q9Y5V3,P57105,Q9Y6C9,Q96P70,O43292,Q9Y5M8,Q5T9L3,Q8NFQ8,P13473,Q9Y5L4,Q969Q5,P53367,Q9BUN8,O00264,Q13535,P52789,Q15363,Q9NR31,Q13277,Q5HYI8,Q9Y5X3,Q9H4A6,Q8TCT9,Q9H2U1,Q96HY6,Q96RL7,Q9Y6B6,Q13190,P0DP25,P49354,Q9H223,P49755,Q96A33,A0AVF1,Q16625,O15260,O14737,Q13315,Q99959,Q658Y4,O15397,Q8TB36,Q15388,Q96D46,Q9Y6X3,Q07812,Q99797,Q99623,O95391,P35613,Q15154,O43805,Q68CQ4,P11279,Q9C0E2,Q9Y512,Q9Y5J9,Q15041,Q9BVK6,Q92974,O95613,Q15904,Q9UBN7,Q96QU8,O43681,P61020,Q92973,Q7Z3C6,Q7L5D6,P18085,O14777,O14965,P61970,Q96DY7,O00203,Q9NPA0 133 +Organic hydroxy compound metabolic process 0.4136937926003558 2.152969180429295 0.0313211007641129 1.0 0.1087792315598676 119 P54646,Q15392,Q9BQE5,Q14534,Q16850,P38435,Q13510,O76062,Q14849,Q06520,P00374,P48449,P16435,Q14739,P04062,Q8WTV0,P51648,P05067,O15118,Q15800,P49748,P37268 22 +Diol biosynthetic process 0.7623597530233763 2.1528457174526596 0.031330805798255 1.0 0.1087792315598676 7 P04062,P00374 2 +Diol metabolic process 0.7623597530233763 2.1528457174526596 0.031330805798255 1.0 0.1087792315598676 7 P04062,P00374 2 +Organic hydroxy compound biosynthetic process 0.4763109441700781 2.146639387587065 0.0318220016514863 1.0 0.1097875787786819 55 P54646,Q13510,Q15392,O76062,P04062,Q15800,Q14534,Q16850,P00374,P48449,P16435,Q14739,P37268 13 +Inorganic anion transmembrane transport 0.7441384253092659 2.1395292011241147 0.0323928335779846 1.0 0.111402228866824 9 Q9UHG3,P55011,Q4KMQ2,P51798,Q9UBX3 5 +Amide transport 0.5055795857555528 2.136371785778635 0.0326491218869431 1.0 0.1119934855316888 41 Q03519,Q16836,Q8NE86,P07602,Q9P2D1,Q15907,Q8N5M9,Q9NZJ7,Q03518,P08183,Q9H2D1 11 +Transmission of nerve impulse 0.7585896382799429 2.135139095433632 0.0327496500134347 1.0 0.1122796255946494 7 P42345,P04062 2 +Purine nucleotide transport 0.750489681489934 2.1324583495982345 0.0329691849861324 1.0 0.1128553948247266 8 Q8TB61,P12236,O43808,P12235 4 +Vesicle fusion with golgi apparatus 0.6709084783800079 2.131411938471183 0.0330552202015648 1.0 0.1130319723619949 3 Q13190 1 +Regulation of nitric oxide synthase activity 0.7563770148934599 2.124731252780164 0.0336090440987042 1.0 0.1139589835036641 7 P0DP25,P00374,Q8WTV0 3 +Cellular monovalent inorganic cation homeostasis 0.5760307287651298 2.122070485839467 0.0338318194210176 1.0 0.1144352572374834 25 Q8N511,O75503,Q9Y487,P50897 4 +Cellular response to copper ion 0.6684575147494956 2.118699765982453 0.0341158481437031 1.0 0.1150874050285587 3 P05067 1 +Organelle disassembly 0.4779020427990502 2.116213136878543 0.0343266844286886 1.0 0.115572962145231 52 P42858,P04062,P12235,P30536,Q13190,Q9UBN7,Q7Z3C6,P52789,P27544,P21796,Q99623,Q96HY6,Q9BWH2 13 +Negative regulation of t cell differentiation 0.7044376818503686 2.114206799386124 0.034497608395871 1.0 0.1160123884761594 4 P32119 1 +Antifungal innate immune response 0.6309801633605676 2.1123337223396947 0.0346578353691833 1.0 0.1162703045463301 2 Q9Y4E8 1 +Response to yeast 0.6309801633605547 2.112333722339622 0.0346578353691895 1.0 0.1162703045463301 2 P46108 1 +Regulation of monocyte chemotaxis 0.7039600966780875 2.111841636522685 0.0347000347110595 1.0 0.1163158841843516 4 Q4KMQ2,P09429 2 +Multicellular organism aging 0.7298857482263205 2.109151425692694 0.0349315131493488 1.0 0.1167705498145833 10 O75844,P14735,P04062 3 +Aorta morphogenesis 0.7024609908903374 2.10441357392648 0.0353423863738613 1.0 0.1177242331904964 4 Q96AY3,Q9P2D1 2 +Oxidative demethylation 0.6648697344441171 2.1000592286496715 0.0357236312716489 1.0 0.1187640129302489 3 Q6P6C2 1 +Oxidative rna demethylation 0.6648697344441171 2.1000592286496715 0.0357236312716489 1.0 0.1187640129302489 3 Q6P6C2 1 +Sterol homeostasis 0.7038400111555586 2.097793841731355 0.035923360766175 1.0 0.1191632962945111 12 Q5BJF2,Q8WTV0 2 +Response to ether 0.7003774728381295 2.0940797228161583 0.0362528790557297 1.0 0.1194613517997687 4 Q9H4A6 1 +V d j recombination 0.742458313393947 2.0940002899986885 0.0362599544167876 1.0 0.1194613517997687 8 P09429,Q13315,Q13426 3 +Maintenance of location 0.4461085682723307 2.093892446775742 0.0362695622765163 1.0 0.1194613517997687 74 P42858,P24390,Q96RL7,P04062,Q8WTV0,P78417,P17900,P30536,P52789,Q9H4A6,Q14534,P0DP25,O43292,Q9P2D1,O95202,O43731,P10253 17 +Peptide catabolic process 0.7184909979550825 2.0934446489616554 0.0363094802427526 1.0 0.1194764698632117 11 P55786,P42892,P14735,O14773,Q9UIQ6 5 +Maintenance of protein location in cell 0.5718212963188642 2.0932861937928378 0.0363236143518908 1.0 0.1194764698632117 25 P24390,P30536,P52789,Q9H4A6,O43292,O43731 6 +Ribonucleoside metabolic process 0.7494535142947242 2.0920874484964163 0.0364306937380882 1.0 0.1196371130610411 7 Q13126,O60725 2 +Purine ribonucleoside metabolic process 0.7494535142947242 2.0920874484964163 0.0364306937380882 1.0 0.1196371130610411 7 Q13126,O60725 2 +Mitochondrial calcium ion transmembrane transport 0.741808999479099 2.090884025441646 0.0365384614265564 1.0 0.1196371130610411 8 Q8IYU8,P21796,O95202,Q8NE86 4 +Glial cell proliferation 0.7560315883310078 2.089581509435059 0.0366554089640978 1.0 0.119668056528562 6 P30536,Q96G23 2 +Regulation of protein neddylation 0.7273493560201794 2.0886153070234923 0.0367423661643631 1.0 0.119892295758603 5 Q96GG9,Q92564 2 +Hormone biosynthetic process 0.725051925066914 2.085180000841533 0.0370529645536166 1.0 0.1207256968226575 10 Q53GQ0,Q14849,P30536,P16435 4 +Negative regulation of oxidoreductase activity 0.7259432687179477 2.0818579275227314 0.0373554487120431 1.0 0.1212896855261884 5 Q15070,P06280 2 +Regulation of autophagy of mitochondrion 0.6514109891050079 2.077947118223044 0.0377142300541997 1.0 0.12215088693221 15 P42858,P30536,Q9UBN7,P27544,P21796,P12235 6 +Regulation of dna ligation 0.6605948610729035 2.07779911555559 0.0377278653348938 1.0 0.12215088693221 3 P09429 1 +Regulation of er to golgi vesicle mediated transport 0.7533243577676123 2.0769803767652695 0.0378033704011608 1.0 0.1223203730633223 6 Q9Y6B6,Q9NR31,Q9P2W9,Q6NUQ1 4 +Negative regulation of cell killing 0.7228594108878226 2.067020197572687 0.0387322508164529 1.0 0.1247110058182355 5 P04439,P01889 2 +Regulation of neuron projection arborization 0.6577181208053604 2.0627890088877 0.039132678753307 1.0 0.1254463302292139 3 Q9HCE1,Q15334 2 +Negative regulation of membrane potential 0.6573603820067218 2.0609207150120357 0.039310604678268 1.0 0.12561496150148 3 Q07812 1 +Antigen processing and presentation of endogenous peptide antigen 0.7279527095496457 2.060629238182141 0.0393384251578088 1.0 0.12561496150148 9 Q03519,P01889,P14735,Q03518,Q9NZ08 5 +Antigen processing and presentation of endogenous antigen 0.7279527095496457 2.060629238182141 0.0393384251578088 1.0 0.12561496150148 9 Q03519,P01889,P14735,Q03518,Q9NZ08 5 +Steroid hormone biosynthetic process 0.7347607923714446 2.0569899481280216 0.0396871927814963 1.0 0.1262372074804551 8 Q14849,P30536 2 +Response to vitamin a 0.6564941839688616 2.0563954304483643 0.0397444164009248 1.0 0.1263579750110799 3 P04818 1 +Phototransduction 0.6925176497884876 2.054991833515321 0.0398797935007688 1.0 0.1266656364724324 4 Q13432 1 +Mitochondrial fusion 0.6637425242802333 2.0543994242097714 0.0399370487553514 1.0 0.1267248133136441 14 Q8N2A8,Q7Z6Z7,Q9Y6C9,Q8NAN2,Q07812,Q9UJZ1,Q99536,Q8TB36 8 +Sterol biosynthetic process 0.5582248512962603 2.051911267574047 0.0401782866226518 1.0 0.1272441683483791 26 P54646,Q15392,O76062,Q15800,Q14534,Q16850,P48449,P16435,P37268 9 +Lipophagy 0.7188301940319166 2.047598198965982 0.040599385975925 1.0 0.1282682574742514 5 P42858 1 +Dna replication synthesis of rna primer 0.6545083163116517 2.0460123337522926 0.0407551572120519 1.0 0.1286984319660657 3 P49642,P49643 2 +Mitophagy 0.6449597317855569 2.0412148401826986 0.0412294772761632 1.0 0.1296298323524236 15 Q7Z6Z7,P50851,Q9UBN7,P27544,P21796,P05141,Q99623,P12235,Q14457 9 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.7172226342778429 2.0398380199729544 0.0413664616370073 1.0 0.129816700747031 5 Q8TB61 1 +Regulation of histone h2b ubiquitination 0.6889908868665999 2.0373992341607465 0.0416100505575529 1.0 0.1303318146819391 4 P50750 1 +Copi coated vesicle budding 0.7438305669386014 2.0326550707512374 0.0420873834920298 1.0 0.1315757077059076 6 Q15363,P49755 2 +Proton transporting two sector atpase complex assembly 0.7152517313277214 2.0303151212576767 0.0423245181453491 1.0 0.1320402144478482 5 Q8N511 1 +Response to oxygen radical 0.6515039680266184 2.0302821572268126 0.0423278668357973 1.0 0.1320402144478482 3 P00374 1 +Cellular response to oxygen radical 0.6515039680266184 2.0302821572268126 0.0423278668357973 1.0 0.1320402144478482 3 P00374 1 +Cellular response to brain derived neurotrophic factor stimulus 0.6146441073512341 2.022734272068839 0.0431005514333571 1.0 0.1337870475428994 2 P38919 1 +Folic acid metabolic process 0.7407427167710771 2.0181931169324376 0.0435711527242701 1.0 0.1348650491399343 6 P00374 1 +Cellular copper ion homeostasis 0.6849255892576032 2.017079305699028 0.0436872378567068 1.0 0.1351606104741678 4 P05067 1 +Maintenance of protein localization in organelle 0.6035160096853885 2.0090801393218594 0.0445286355363134 1.0 0.1369245109603041 19 O43292,O43731,P24390,P30536 4 +Vesicle transport along microtubule 0.6382626231961266 2.0029317978297456 0.0451846094916146 1.0 0.1383771717849518 15 P62820,P42858,Q14204,Q9Y496,O00203,Q92572,Q9BQS8,P43034,O14617,Q9Y2T2 10 +Pinocytosis 0.730144181044855 2.0004352728771213 0.0454532827437652 1.0 0.1390510216151923 7 Q9Y5X3,P50897,Q9H223 3 +Purine nucleoside diphosphate catabolic process 0.6105600933488972 2.000199220523949 0.0454787559643321 1.0 0.1390641177250454 2 Q9BW91 1 +Collateral sprouting 0.6808901210615226 1.996865299964103 0.045839817597278 1.0 0.1400376550620757 4 P05067 1 +Oxidative phosphorylation 0.453362899785509 1.9948008592069608 0.0460646036302732 1.0 0.1405280934550687 61 O75964,Q9BSK2,P14406,P03886,P22695,P13073,O14949,P00403,P24539,O43676,Q9UDW1,P47985 12 +Regulation of myeloid leukocyte mediated immunity 0.7135484904141812 1.9898496709163216 0.0466074978994461 1.0 0.1414608701277362 9 P09601 1 +Positive regulation of mitophagy in response to mitochondrial depolarization 0.6792094089071178 1.9884338324801805 0.046763730138033 1.0 0.1418694392814483 4 Q7Z6Z7,Q9UBN7 2 +Fatty acid alpha oxidation 0.6788717922910881 1.9867392497512957 0.0469512998705505 1.0 0.1423545670333355 4 O43808,A1L0T0 2 +Positive regulation of autophagy of mitochondrion 0.7340128411252267 1.986597414437796 0.0469670279834153 1.0 0.1423545670333355 6 P27544,P12235,P21796 3 +Positive regulation of b cell proliferation 0.642852179018027 1.9848361995128172 0.0471626985685398 1.0 0.1428157028180703 3 P02786 1 +Chloride transport 0.6653846870309859 1.9766994031147824 0.0480756183273309 1.0 0.1451781902733299 13 Q9UHG3,P55011,P30536,Q9C0H2,P51798 5 +Production of sirna involved in rna interference 0.6764523386777623 1.9745866718780107 0.0483150727976986 1.0 0.1456332143768941 4 O75569,Q15631 2 +Response to ketone 0.4844160431692392 1.9724544490593952 0.0485577513616974 1.0 0.1460962698007606 42 P54646,Q9H7B4,P04062,P16278,P30536,Q9H4A6,P0DP25,Q13126,P20020 9 +Positive regulation of monooxygenase activity 0.7309447977447865 1.9721588917735535 0.048591470802032 1.0 0.1461307201663311 6 P0DP25,P00374,Q8WTV0 3 +L ascorbic acid metabolic process 0.6750767547704151 1.967670486429467 0.0491059637685098 1.0 0.1467819333857022 4 P78417 1 +Response to food 0.7015618808064403 1.963904969084921 0.0495411135007852 1.0 0.1478348280091646 5 P80303,Q9UMX5 2 +Antigen processing and presentation 0.5530054546997936 1.9635459908135928 0.0495827660113099 1.0 0.147891868439189 25 P61020,Q03519,P04062,P01889,Q9Y6B6,P14735,Q9NZ08,Q9UIQ6,O00203,P50570,Q03518,P20337,O14617 13 +Regulation of mitophagy 0.7215780447039538 1.959491482429229 0.050055256417824 1.0 0.1489626270357194 7 P12235,P21796 2 +Positive regulation of necrotic cell death 0.7200558936326804 1.9521979364198203 0.0509147091027177 1.0 0.1509268747085738 7 P00403,Q7Z3C6,P30536 3 +Positive regulation of dna demethylation 0.601808634772458 1.951730142205702 0.050970251983736 1.0 0.1510008097143458 2 Q93008 1 +G2 mi transition of meiotic cell cycle 0.6360875763876068 1.9491526223859856 0.0512772009610493 1.0 0.1517731135346892 3 O95067 1 +Mitotic dna replication checkpoint signaling 0.6981021897810131 1.9470492922378992 0.0515288253977044 1.0 0.1523804201260642 5 Q9Y619,Q99741,Q92547,Q13564 4 +Positive regulation of calcium ion transport 0.5831315041673045 1.9404005060838136 0.052331035146875 1.0 0.1542752073717188 20 P42858,P78417,P30536,P0DP25,O76024,P17931,Q07812,Q96GC9,P20020 9 +Necrotic cell death 0.59244103083086 1.9401437878569323 0.0523622177311531 1.0 0.1542752073717188 19 Q13510,P49327,Q92974,Q7Z3C6,P30536,Q07812,P00403,P12235 8 +Growth hormone secretion 0.6338727559604591 1.937440895969694 0.0526914716236261 1.0 0.1542752073717188 3 Q9P2D1 1 +Myeloid leukocyte cytokine production 0.7027983537494813 1.9366842955328676 0.0527839466157571 1.0 0.1542843018675271 9 P09601 1 +B cell homeostasis 0.6688483161803496 1.936293484769232 0.0528317663075268 1.0 0.1543553207969684 4 Q07812 1 +Negative regulation of secretion 0.5914749774231223 1.9341075729222148 0.0530999030255219 1.0 0.154754799618977 19 Q16850,P09601,Q8N5M9 3 +Amyloid beta clearance 0.7014807530963316 1.930148193363573 0.0535884785034219 1.0 0.1559412842303569 9 Q15907,Q16850 2 +Meiotic spindle organization 0.7077463461785996 1.9259483215951043 0.0541108269437486 1.0 0.1566278105006082 8 O14965,O14777,O95067 3 +Iron ion homeostasis 0.5990940593096078 1.9251658907720732 0.0542086078323893 1.0 0.1568004441268289 18 Q8N511,P30519,P09601 3 +Secretion 0.370428527474861 1.92452795795412 0.0542884397846747 1.0 0.156934247518518 155 Q13277,P55011,Q9Y5X3,Q9H4A6,Q16850,P09601,P11279,Q9BRK5,P55327,Q9H7Z7,P0DP25,P50897,P49755,Q99584,Q5T9L3,Q13505,Q9P2D1,Q96KC8,P53367,Q8N5M9,P00403,Q96PC5,Q16836,P52789,Q15907,Q96KP1,P16615 27 +Regulation of glial cell proliferation 0.6926057837118709 1.920211190088532 0.0548312287359138 1.0 0.1581549551494798 5 P30536 1 +Circulatory system process 0.4273716852497901 1.9195630757224351 0.0549131118313388 1.0 0.1583215465014259 81 P42892,Q16625,P42345,P78417,Q9Y5X3,Q99959,P42785,Q9UIQ6,O75844,P09601,P0DP25,Q9P2D1,P20020,Q9HB40,P16615,Q9NZ08,P30825,P10253 18 +Regulation of monooxygenase activity 0.6916917020964857 1.9180675095920123 0.0551024515642988 1.0 0.1587279574911891 10 Q8WTV0,P0DP25,Q8TCT9,P00374,P16435 5 +Nitric oxide mediated signal transduction 0.5950991831971969 1.9144064410146568 0.0555682432052111 1.0 0.1597500331761861 2 P23634 1 +Prostate gland development 0.71805580508952 1.9112680737534704 0.0559701396739871 1.0 0.1600749497643548 6 P07602 1 +Negative regulation of arp2 3 complex mediated actin nucleation 0.5945157526254482 1.9111542421486043 0.0559847622232847 1.0 0.1600749497643548 2 Q9BR76 1 +Negative regulation of actin nucleation 0.5945157526254482 1.9111542421486043 0.0559847622232847 1.0 0.1600749497643548 2 Q9BR76 1 +Ceramide catabolic process 0.7032887343428023 1.9041554419162952 0.0568899428882239 1.0 0.1617299839459572 8 Q13510,P04062,P17900 3 +Locomotory behavior 0.5058066672169717 1.8978042028681337 0.0577218793720564 1.0 0.16333375266901 33 P05067,O15118,Q96RL7,Q9P2D1,O75844,P50897,P54802,P10253 8 +Female sex differentiation 0.6032136645322953 1.897035580936808 0.057823242236946 1.0 0.1635500498098447 17 O95470,Q13315,Q9P2D1,Q07812,P49770,O15360 6 +Granulocyte differentiation 0.7084462563136719 1.89639156864651 0.0579082859427337 1.0 0.1637200225576127 7 Q14739,P49327,Q8N5M9,O00203 4 +Ether metabolic process 0.7013762126276027 1.8947907834758024 0.0581201247178071 1.0 0.1642481732981268 8 Q6IAN0,P49327,O15228,O00116,P07099,P43034 6 +Response to amyloid beta 0.6867346799584011 1.8914634996553028 0.0585624989631885 1.0 0.1649511539724156 5 P05067,P09874 2 +Cellular response to amyloid beta 0.6867346799584011 1.8914634996553028 0.0585624989631885 1.0 0.1649511539724156 5 P05067,P09874 2 +Axoneme assembly 0.6599725404671463 1.8914074342350151 0.0585699769514977 1.0 0.1649511539724156 4 A0AVF1,Q15555 2 +Growth plate cartilage development 0.6238989998789364 1.884528916540311 0.0594934672030555 1.0 0.1671932041911994 3 O75844 1 +Bone growth 0.6238989998789364 1.884528916540311 0.0594934672030555 1.0 0.1671932041911994 3 O75844 1 +Response to dexamethasone 0.6916484075224862 1.8812385737655477 0.0599394726754209 1.0 0.1681066502997585 9 Q9H7B4,P04062 2 +Regulation of necrotic cell death 0.6625426321742105 1.8811575900776685 0.0599504848703267 1.0 0.1681066502997585 12 Q13510,Q92974,Q7Z3C6,P30536,P00403,P12235 6 +Protein localization to organelle 0.3284403912277827 1.8809978301311188 0.0599722140127605 1.0 0.1681066502997585 344 P55060,Q9NS69,P24390,P30536,P46934,Q13426,Q14108,Q8N4H5,O60830,P09874,O76094,O75381,Q15555,Q99595,O43731,Q9Y584,P06493,O95071,O94901,Q00535,Q5JRX3,Q15629,Q15554,Q14789,O75190,Q14149,O14773,Q99523,P46379,O14925,Q15070,Q9NQC3,P55786,Q7Z4Q2,Q9P0J0,P52292,Q9Y5V3,Q9Y6C9,Q96P70,O43292,Q9Y5M8,Q8NFQ8,P13473,Q9Y5L4,Q13535,P52789,Q9H4A6,Q96HY6,Q96RL7,P0DP25,P49755,Q96A33,A0AVF1,O14737,O15397,Q8TB36,Q15388,Q96D46,Q9Y6X3,Q07812,Q99797,Q99623,Q15154,Q68CQ4,P11279,Q9Y512,Q9Y5J9,O43681,Q92973,Q7L5D6,P18085,O14777,O14965,P61970,Q96DY7,O00203,Q9NPA0 77 +Cellular response to nutrient 0.711230333444623 1.8788716520658364 0.060262020414749 1.0 0.1686206401200559 6 P09601,P20020 2 +Response to mitochondrial depolarisation 0.6969348464557089 1.8730102704107567 0.061066966773869 1.0 0.1703747601913811 8 P04062,Q7Z6Z7,P52789,Q9UBN7,Q14457 5 +Positive regulation of peptidyl threonine phosphorylation 0.7028286551235968 1.8692768034365803 0.061584313653578 1.0 0.1715264287753732 7 P05067 1 +Endoplasmic reticulum calcium ion homeostasis 0.6815895276581034 1.86689601051893 0.0619161111038712 1.0 0.1720853541141903 10 P05067,Q9UM00,Q07812,O76024,P16615,Q96A33 6 +Maintenance of location in cell 0.4581938018128875 1.865601052936271 0.0620972022091377 1.0 0.1721882139965649 49 P42858,P24390,Q96RL7,P78417,P30536,P52789,Q9H4A6,Q9P2D1,P0DP25,O43292,O95202,O43731,P10253 13 +Dicarboxylic acid transport 0.5978648788097717 1.864785517490729 0.0622114740988597 1.0 0.1723951406405057 17 Q02978,Q15041,O60831,P55011,Q15042,Q9UBX3,Q9BQT8,Q9H2D1 8 +Genitalia development 0.7081476299159701 1.8642060616718137 0.0622927724574804 1.0 0.1724747564835386 6 Q15392,Q9P2D1 2 +Positive regulation of mitochondrial translation 0.6934106892800294 1.85569478157626 0.0634970750514125 1.0 0.1741194343866983 8 Q9Y2R0,Q567V2 2 +Response to corticosteroid 0.5068901273425784 1.855397360628136 0.0635395040269626 1.0 0.1741630014306302 31 Q9H7B4,P04818,P04062,P16278,P0DP25,P20020,P16435,P42574 8 +Regulation of steroid biosynthetic process 0.6791921442498466 1.854714614148343 0.0636369907252636 1.0 0.1742991862608028 10 Q13510,P30536,P16435 3 +Inner mitochondrial membrane organization 0.5573925918195265 1.85467737269765 0.0636423118379889 1.0 0.1742991862608028 22 Q9Y512,Q5XKP0,Q13505,Q9Y5L4,Q9BUR5,Q9P0J0,O95202,Q9Y584 8 +Long chain fatty acid transport 0.6121980122461428 1.852496656778296 0.063954537194828 1.0 0.1744262980351045 15 O43772,P23786 2 +Response to testosterone 0.6712176416116729 1.8518043951235557 0.0640539163026241 1.0 0.1746247606056583 11 P04062,P30536 2 +Ubiquitin recycling 0.6520753223503537 1.851302166573628 0.0641260945842245 1.0 0.1746894772801786 4 P14735 1 +Primary alcohol catabolic process 0.6174011004227182 1.849907500221195 0.0643268827018588 1.0 0.1748439931030483 3 Q06520 1 +Ethanol catabolic process 0.6174011004227182 1.849907500221195 0.0643268827018588 1.0 0.1748439931030483 3 Q06520 1 +Protein import into mitochondrial matrix 0.6851210688837387 1.848638992574656 0.0645099583502684 1.0 0.1748439931030483 9 Q99595,O14925,O60830 3 +Positive regulation of glucose import 0.6166284100779706 1.8457828068538136 0.0649237480044069 1.0 0.1751766588836012 3 Q16625 1 +Cell volume homeostasis 0.7037702317399405 1.843345290327158 0.0652786124809747 1.0 0.1759894228020363 6 Q4KMQ2,P55011,P54105,Q9NUT2 4 +Nucleoside diphosphate catabolic process 0.6157593928158633 1.8411419632839217 0.0656007576020838 1.0 0.1762785304606364 3 Q9UKK9 1 +Ribonucleoside diphosphate catabolic process 0.6157593928158633 1.8411419632839217 0.0656007576020838 1.0 0.1762785304606364 3 Q9UKK9 1 +Regulation of toll like receptor signaling pathway 0.6835855387704062 1.8409551547229823 0.0656281307657913 1.0 0.1762798993389777 9 Q9NPR9,P09429,Q9NQC3 3 +Cellular response to chemical stress 0.41894884183605 1.840325204584161 0.0657205071369808 1.0 0.1764557969856253 84 P54646,Q13546,P30536,Q07820,P09601,Q8N0U8,Q99720,O95202,P42574,Q92974,P09874,Q9UBN7,P32119,P00374,Q8IXJ6,P04062,P06493,Q13315,Q8TED1,P49327,O75569,P16615 22 +Positive regulation of histone phosphorylation 0.6494107290508375 1.83773512936112 0.0661014447184653 1.0 0.1772610054117571 4 Q13315 1 +Lipid translocation 0.675140948285537 1.8344560931009344 0.0665863196565077 1.0 0.1780596171200944 5 Q7Z3C6,Q96GC9,P08183 3 +Regulation of membrane lipid distribution 0.675140948285537 1.8344560931009344 0.0665863196565077 1.0 0.1780596171200944 5 Q7Z3C6,Q96GC9,P08183 3 +Protein o linked glycosylation via serine 0.6487634327133345 1.8344367040236331 0.0665891954301602 1.0 0.1780596171200944 4 Q8N4A0 1 +Response to manganese ion 0.6750179932858091 1.8338498339954492 0.0666762879755942 1.0 0.1782198784911809 5 P30536 1 +Proteolysis 0.3101683171655489 1.8257829015083111 0.0678829698516298 1.0 0.1804894846703384 414 Q15392,Q16740,Q8N3C0,P46934,P51812,Q6NTF9,Q5VYK3,P42574,P67812,P09874,P42785,Q9H3G5,P49721,Q9HB40,O94822,Q8IXJ6,Q92643,P04062,Q9BXK5,P06493,Q00535,O75844,Q5JRX3,Q92530,Q96A26,Q92820,P20618,Q9UHG3,P22695,O14773,P10619,O75503,P46379,P55786,Q9UIQ6,Q9P0J0,P42892,P60900,O43292,O95628,P28072,Q96KC8,Q9UBU6,Q9BUN8,Q15418,P05067,Q9NZJ7,Q9Y6J9,Q8TCT9,P61289,Q96HY6,P16435,P49755,Q96A33,Q9UPU5,O14737,P14735,A4D1P6,P28074,P48729,Q70CQ2,Q92896,Q07812,Q99797,Q9NZ08,Q96S82,Q9H9S5,Q13867,Q8WW12,Q15041,Q9UBN7,P09429,Q969V3,O76024,Q9H3F6,Q7L5D6,Q6ZXV5,Q16763,O14965,P49327,Q9H1I8,Q14674,Q9UJZ1,Q96FZ2 84 +Positive regulation of stem cell differentiation 0.6728406500068455 1.8231081519404968 0.0682870121764769 1.0 0.1809880742409667 5 Q9Y6C9 1 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.6928716557084824 1.8210413425644976 0.0686005726378977 1.0 0.1809880742409667 7 P52789,P04062,Q7Z6Z7,Q9UBN7 4 +Tor signaling 0.5389628365258712 1.818105407957362 0.0690480236045745 1.0 0.181559174300805 24 P54646,Q15382,P04062,Q13315,Q9H4A6,O75844 6 +Negative regulation of neurotransmitter transport 0.5778879813302239 1.818027061176391 0.0690599968081087 1.0 0.181559174300805 2 Q06787 1 +Negative regulation of neurotransmitter secretion 0.5778879813302239 1.818027061176391 0.0690599968081087 1.0 0.181559174300805 2 Q06787 1 +Dna replication checkpoint signaling 0.6983060747663634 1.8172470820978923 0.0691792887212077 1.0 0.1817271787784487 6 Q99741,Q92547,Q13564,Q9Y619,Q9UNS1 5 +Maintenance of protein location 0.4953596545318028 1.815793424579093 0.0694020663337369 1.0 0.1820280994515849 33 P24390,P30536,P52789,Q9H4A6,O43292,O43731 6 +Organic hydroxy compound transport 0.4920012985721493 1.815775603632098 0.0694048011014729 1.0 0.1820280994515849 34 Q14849,P30536,Q8WTV0 3 +Regulation of vacuole organization 0.663650054741323 1.8125752512371145 0.0698973578062391 1.0 0.1830386129737591 11 Q14108 1 +Double strand break repair via break induced replication 0.6828393774201014 1.803581338486622 0.0712969637420659 1.0 0.1858763115118938 8 Q9Y248,Q14566 2 +Protein insertion into er membrane 0.6479272245188279 1.8033476410893177 0.0713336350142439 1.0 0.1858980591594395 12 P46379,Q7L5D6,O43681,Q15629,Q96A33 5 +Amino acid transport 0.5694305547696656 1.7953829267417358 0.072592710775293 1.0 0.1881652313013629 19 Q15041,O60831,P55011,Q9Y619,Q6P4A7,Q96NB2,P30825 7 +Olfactory lobe development 0.641093555892181 1.7952752019037337 0.0726098639900172 1.0 0.1881652313013629 4 Q9UPW5,Q9P2D1 2 +Regulation of cysteine type endopeptidase activity 0.4437418743257481 1.794945371072732 0.0726624041630072 1.0 0.1881652313013629 52 Q15392,P09429,Q15041,Q9BXK5,O14737,Q07812,P51812,Q9NZJ7,Q9P0J0,P16435,Q96A26,Q15418 12 +Behavior 0.4165038487520285 1.7895120730452854 0.0735323849019715 1.0 0.1899683109160383 79 Q15154,P42858,P53985,P30536,Q13641,P42574,Q96RL7,P50897,P43034,P04062,Q9P2D1,O76024,O75844,O00264,P18085,P10253,P05067,O15118,P42345,P17900,Q7Z2T5,P54802 22 +Adult locomotory behavior 0.585258725566249 1.7883791406103204 0.0737148593583978 1.0 0.1902898926474455 17 O75844,P05067,O15118,P50897 4 +Calcium ion transport 0.4326573707452172 1.786846938924631 0.0739622304643707 1.0 0.1906284981567954 61 P42858,P30536,P17931,P21796,P20020,O95202,Q9UM00,Q8NE86,P0DP25,Q96GC9,Q6YHU6,Q00535,O76024,Q9P2D1,O75844,P78417,Q07812,Q9UJZ1,P16615,Q8IYU8 20 +Regulation of amyloid precursor protein catabolic process 0.6304162615970414 1.7858644570068245 0.0741212071141907 1.0 0.1908284028681968 13 Q96P70,O95197,Q9NQC3 3 +Photoreceptor cell development 0.6652096780860356 1.7853761631671583 0.0742003223980667 1.0 0.1908284028681968 5 P54802,Q15555 2 +Presynaptic modulation of chemical synaptic transmission 0.6049022468631354 1.7829894371675654 0.0745880227934541 1.0 0.1914892823046345 3 P35268,Q00535 2 +Mast cell activation involved in immune response 0.6909659996246789 1.7820883788154218 0.0747348206127345 1.0 0.1916412242519592 6 P09601 1 +Vesicle mediated transport 0.3086267810441223 1.7806391313184895 0.0749714227906801 1.0 0.1918294390732076 387 O95249,Q9Y3B3,P24390,P42858,Q13277,P55899,O75165,Q9Y5X3,Q9H4A6,Q2M389,P09601,P46934,P17931,Q14108,Q7L576,Q8TBA6,P11279,Q9BRK5,Q8NHH9,P57105,O75955,O15127,Q96RL7,O15400,Q9BVK6,Q9Y6B6,O95197,Q14849,Q15904,Q13190,Q5VW38,P0DP25,Q9Y5X2,Q15057,P50897,Q9H223,P20337,O43731,P49755,Q99584,O95487,P61020,Q9BXW6,P09429,Q9H5V9,O15260,Q4KMP7,Q8WTV0,Q00535,Q658Y4,P53367,Q8N5M9,A4D1P6,Q8NBN3,Q9Y282,Q08380,P18085,Q96PC5,Q9NX40,P05067,O15118,Q9P2W9,Q12907,O00203,Q15907,Q15363,Q96KP1,P50570,O75503,Q9NR31,P16615,Q13432 72 +Leukotriene biosynthetic process 0.6043186460461017 1.779854692353072 0.0750997441757528 1.0 0.1918294390732076 3 Q99735,O14880 2 +Regulation of modification of synaptic structure 0.6380153982799915 1.779518414635986 0.0751548086028111 1.0 0.1918294390732076 4 Q9UQB8 1 +Regulation of modification of postsynaptic structure 0.6380153982799915 1.779518414635986 0.0751548086028111 1.0 0.1918294390732076 4 Q9UQB8 1 +Positive regulation of ion transport 0.4524859744415797 1.7742627318193471 0.076019702024229 1.0 0.1934993346326574 47 P42858,Q15041,P78417,P55011,P30536,Q99959,Q00535,P0DP25,O76024,P17931,P50570,Q96GC9,Q07812,P20020,P08183,P20337 16 +Positive regulation of leukocyte degranulation 0.6368261816073209 1.773424861533455 0.0761583323829326 1.0 0.1936943913586568 4 O95219,P11279 2 +T cell differentiation involved in immune response 0.6365179579169511 1.77184497238606 0.0764202949341925 1.0 0.1937673784227865 4 P42345 1 +Blood vessel endothelial cell migration 0.5322170846671935 1.7713537311792316 0.0765018975893943 1.0 0.1938596183430866 24 P09601,P42785 2 +Neuron apoptotic process 0.4371774756447236 1.7707332407252108 0.0766050720540842 1.0 0.1940109929829799 55 P05067,P49327,P04062,P09874,Q13315,Q07820,P09601,O76024,Q07812,P50897,Q99720,Q01105,Q96A26,P42574 14 +Innervation 0.6025294477731716 1.770238650912329 0.0766873931319573 1.0 0.1940873032188088 3 P42892 1 +Regulation of hormone metabolic process 0.6621472524918655 1.7701968253983276 0.0766943580076762 1.0 0.1940873032188088 5 O75844 1 +Vesicle tethering 0.6360322221619096 1.769354736282042 0.0768346942677722 1.0 0.1942925872004321 4 Q14849 1 +Negative regulation of cytokine production involved in inflammatory response 0.569136522753805 1.7686800229158783 0.0769472879269206 1.0 0.1943977377356986 2 Q53EL6 1 +Gland development 0.4155823305369438 1.768573051459417 0.0769651512705493 1.0 0.1943977377356986 76 P30536,P09601,P62841,P32119,Q5T9L3,P04818,O95067,Q13505,Q13315,P07602,O75844,P00403,Q15418,O14965,P52789,Q07812,Q9NZJ7,Q99623,Q9NQC3 19 +Protein quality control for misfolded or incompletely synthesized proteins 0.6271258366921614 1.767726831428362 0.077106582135797 1.0 0.1946051507596538 13 P46379,Q16740 2 +Camera type eye morphogenesis 0.6686886671227156 1.766121231416429 0.0773755122140844 1.0 0.1949860707993344 9 Q07812,P54802,Q16706,Q15555 4 +Negative regulation of calcium ion transmembrane transport 0.67519974959667 1.7657619351030742 0.0774357970897692 1.0 0.1949860707993344 8 P21796,P78417 2 +Phospholipid transport 0.5971251592620871 1.7644849279390302 0.0776503707090539 1.0 0.1953555758862707 15 Q8WTV0,Q7Z3C6,Q96GC9,Q14108,P08183 5 +Myeloid leukocyte mediated immunity 0.5893319262380978 1.7643572389312991 0.0776718527106492 1.0 0.1953555758862707 16 P09601,Q8N5M9,Q9H2U1 3 +Regulation of calcium ion transport 0.4747472913109839 1.7616903035705966 0.0781216370177637 1.0 0.1961322003043223 37 P42858,P78417,P30536,Q9P2D1,P0DP25,O76024,P17931,Q07812,P21796,Q96GC9,P20020,Q6YHU6 12 +Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.5673862310385069 1.7587839054670735 0.0786142194798262 1.0 0.196970793519137 2 Q13043 1 +Antigen processing and presentation of exogenous antigen 0.6731760968868109 1.755722167314412 0.079135859849448 1.0 0.1976242528922821 8 Q9UIQ6,P50570,O00203,Q03518,O14617 5 +Neuromuscular process 0.4963761619843685 1.7516752257080102 0.0798296692060713 1.0 0.1990282254294226 30 P05067,P04062,P78417,P17900,O14773,O75844,P10253 7 +Neutral amino acid transport 0.632507036498307 1.7512653609428377 0.0799002114568316 1.0 0.1991284419216595 4 Q96NB2 1 +Male meiosis i 0.598404200733755 1.7480357772556991 0.0804578324482054 1.0 0.2000622571144844 3 P54652 1 +Sarcoplasmic reticulum calcium ion transport 0.6581923139674469 1.7474093663150123 0.0805663539359913 1.0 0.2001803917182791 10 P0DP25,O75844,P16615,P78417 4 +Rhythmic behavior 0.656843626346366 1.7438594936518808 0.0811835933346776 1.0 0.2014851510825092 5 P54802 1 +Vesicle cytoskeletal trafficking 0.5406398402130572 1.742606796791456 0.0814023219749426 1.0 0.2018752973543363 22 P62820,P42858,Q12965,O94832,Q14204,Q9Y496,O00203,Q92572,P78537,Q9BQS8,P43034,O14617,Q9Y2T2 13 +Response to wounding 0.409577603164264 1.7387541327102658 0.0820780196972885 1.0 0.2030904846355986 85 P55011,P30536,P09601,P38435,P42574,P52429,P42785,P32119,P00374,Q9BWH2,Q96G23,Q16625,Q8WTV0,P06493,Q00535,O14965,P42345,Q96AY3,O00203,Q07812,Q99623 21 +Positive regulation of tau protein kinase activity 0.5635939323220585 1.7373123474709942 0.0823320532675735 1.0 0.2035671284495885 2 P07900 1 +Protein insertion into mitochondrial inner membrane 0.6752928166984626 1.7353498289402078 0.0826788608257818 1.0 0.2039949043567417 7 Q9Y5L4,Q9P0J0,Q9Y584 3 +Regulation of endothelial cell migration 0.4940312635228377 1.7336830436599464 0.0829743367368613 1.0 0.2045461552138753 30 P09601,Q8WTV0,P42785 3 +Telomerase holoenzyme complex assembly 0.680894429695814 1.733662212606822 0.0829780349252264 1.0 0.2045461552138753 6 Q13315,Q13535 2 +Intraciliary transport involved in cilium assembly 0.5954941260766795 1.7323468626128344 0.0832118228715967 1.0 0.2049684615928746 3 A0AVF1 1 +Cellular transition metal ion homeostasis 0.5507689259255487 1.731748728543664 0.0833183105006039 1.0 0.2051537536603987 20 Q8N511,P05067,O43819,Q15904,O00203,P09601,O75027,Q9Y487,Q15043 9 +Retrograde transport vesicle recycling within golgi 0.6285470175880368 1.730909984927088 0.0834678204755685 1.0 0.2053311420417707 4 Q9UP83,Q8TBA6 2 +Antigen processing and presentation of exogenous peptide antigen 0.6542094037107767 1.7307553016117485 0.0834954172177786 1.0 0.2053311420417707 5 P50570,Q03518,Q9UIQ6 3 +Golgi vesicle transport 0.3684471462659182 1.729480853983095 0.0837230702387605 1.0 0.205533403257294 138 O95249,Q9Y3B3,P24390,P42858,Q6NUQ1,Q9H4A6,Q92572,Q96A65,O14617,Q9Y678,Q8TBA6,P11279,P62820,Q8NHH9,O75396,O15127,Q96RL7,P61026,Q9BVK6,Q9Y6B6,Q9HCU5,Q13190,Q9Y5X2,O95487,O43731,P49755,A2RRP1,O15258,Q9H5V9,O15260,P61019,Q9Y282,P18085,Q96PC5,O15498,Q9P2W9,Q12907,Q99523,Q15363,P50570,Q96KP1,Q9NR31 42 +Regulation of tor signaling 0.550261846341044 1.7284467779950965 0.083908155083326 1.0 0.2057568436684549 20 P54646,Q15382,P04062,Q9H4A6,O75844 5 +Cellular response to arsenic containing substance 0.6668332975866087 1.724195979813822 0.0846724696479443 1.0 0.2072132248925947 8 P09601,P78417 2 +Inflammatory response 0.4142806583966242 1.7240903299310646 0.0846915375132488 1.0 0.2072132248925947 70 Q6IAN0,P05067,P49327,P09429,P04062,P42345,P60900,Q13315,Q9BQE5,Q8NCG7,Q8IV08,P09601,P42785,P32119,O00203,O15360 16 +Regulation of translation in response to stress 0.6452950418859379 1.7168305037160745 0.0860101457573541 1.0 0.2094098861814212 11 P51812,Q15418 2 +Regulation of golgi organization 0.6582829067779006 1.713544684472447 0.0866123800551048 1.0 0.2106562038256479 9 Q9P2W9,Q13190 2 +Mitochondrial electron transport cytochrome c to oxygen 0.6763852689076755 1.7119139989543954 0.0869125184639874 1.0 0.2110223652343937 6 P13073,P00403 2 +Protein localization to lysosome 0.5804970906466149 1.711425936612172 0.0870025126236291 1.0 0.2110223652343937 16 P13473,Q99523,O00203,P46934,Q14108,O14617,Q9NQC3 7 +Peptidyl lysine deacetylation 0.5916196795800045 1.711425487407438 0.0870025954874398 1.0 0.2110223652343937 3 Q9UBN7 1 +Negative regulation of hormone secretion 0.6762643204648617 1.7113300876646873 0.0870201951118971 1.0 0.2110223652343937 6 Q8N5M9 1 +Negative regulation of peptide secretion 0.6762643204648617 1.7113300876646873 0.0870201951118971 1.0 0.2110223652343937 6 Q8N5M9 1 +Regulated exocytosis 0.4787530906097802 1.709614353610276 0.087337209627337 1.0 0.2115565779160523 34 Q13277,P0DP25,P09601,Q15907,P16615,P49755,Q99584,Q9BRK5 8 +Atp metabolic process 0.3902900558167337 1.7088398952027957 0.0874806104937346 1.0 0.211747608284724 109 O75964,P05067,Q7KZN9,Q9BSK2,P14406,P03886,P22695,P30536,Q9BRR6,P52789,O14949,P13073,P00403,P24539,O43676,Q9UDW1,P47985 17 +Development of primary female sexual characteristics 0.5798929598034912 1.707797385439464 0.0876739443973741 1.0 0.2119809959968936 16 O95470,Q13315,Q07812,P49770,O15360 5 +Negative regulation of fibroblast apoptotic process 0.5906661943591289 1.7062710587162726 0.0879576239339525 1.0 0.2125783800256714 3 Q9HCK8 1 +Animal organ regeneration 0.5637139810000559 1.7061196257660578 0.0879858092273275 1.0 0.2125783800256714 18 P04818,P09601,P31939,O14965,P62841 5 +Regulation of bone mineralization 0.6489236828886935 1.7044159292372911 0.08830341006907 1.0 0.2130319767916315 5 O75844,P20020 2 +Heparan sulfate proteoglycan biosynthetic process 0.6747002920805992 1.7037766911856935 0.0884228141626843 1.0 0.2131187348070313 6 Q96L58,Q7LGA3 2 +Heparan sulfate proteoglycan metabolic process 0.6747002920805992 1.7037766911856935 0.0884228141626843 1.0 0.2131187348070313 6 Q96L58,Q7LGA3 2 +Ventricular cardiac muscle tissue development 0.6620378475272084 1.7003030257178753 0.0890739416182919 1.0 0.2141821930741047 8 O75844,Q99959 2 +Regulation of phospholipase activity 0.6554296087670902 1.6990857190373516 0.0893030337724765 1.0 0.2142929583815777 9 P50897,Q99623 2 +Negative regulation of cytokine production 0.4863615233378639 1.69664309368614 0.0897641573391911 1.0 0.2148859756535327 31 P09601,P30536 2 +Positive regulation of blood circulation 0.6218589323149815 1.6964499996191555 0.0898006916200586 1.0 0.2148859756535327 4 P16615,P09493 2 +Labyrinthine layer development 0.6673176666656838 1.6962568869198025 0.0898372413976447 1.0 0.2148859756535327 7 Q15363,O75190 2 +Cellular response to increased oxygen levels 0.6611702714701 1.6959751691879716 0.0898905826225155 1.0 0.2148859756535327 8 Q8N511,Q15904,Q9Y487 3 +Cognition 0.47703626900208 1.6957814425929736 0.0899272781505979 1.0 0.2148954112251361 34 P05067,P42858,P17900,Q13641,Q9P2D1,P50897,P43034,Q7L576,P18085,P42574,O00264 11 +T cell activation 0.4280001957638024 1.6805896178538713 0.0928426538073758 1.0 0.2203023740036514 55 P24390,Q5HYI8,P17931,O14617,P42574,P32119,Q9NUQ9,O96005,O15360,P04439,P09429,P04062,Q9P2D1,P30825,P42345,P78527,Q96J02,O00203,Q07812,Q9UJZ1 20 +Central nervous system neuron axonogenesis 0.6438473002405658 1.679064106514384 0.0931395506116219 1.0 0.2205635983808961 5 P43034,O75592,O94813 3 +Regulation of atp metabolic process 0.4920107899118705 1.677125196195677 0.0935180027087962 1.0 0.2213799183892933 28 P05067,Q9BSK2,P14406,P30536,P00403 5 +Er overload response 0.6178368262370167 1.675677919455162 0.0938012971183623 1.0 0.2215709545322872 4 O76024,Q96A33 2 +Negative regulation of calcium ion transport into cytosol 0.6177099951362124 1.675022321646065 0.0939298521624834 1.0 0.2216352714456008 4 P78417 1 +Negative regulation of ryanodine sensitive calcium release channel activity 0.6177099951362124 1.675022321646065 0.0939298521624834 1.0 0.2216352714456008 4 P78417 1 +Positive regulation of sequestering of calcium ion 0.6177099951362124 1.675022321646065 0.0939298521624834 1.0 0.2216352714456008 4 P78417 1 +Protein localization to golgi apparatus 0.6439531942904997 1.6740569097067617 0.0941194152994315 1.0 0.2220027329959993 10 Q96RL7,Q9H4A6 2 +Polyamine metabolic process 0.584196410783491 1.6712370993301138 0.0946748550600364 1.0 0.2229086243985341 3 Q9UBN7 1 +Positive regulation of synaptic transmission gabaergic 0.5519253208868287 1.670995426012411 0.0947225812716827 1.0 0.2229086243985341 2 P33176 1 +Positive regulation of regulated secretory pathway 0.642214991355972 1.6709008641715428 0.0947412608118731 1.0 0.2229086243985341 5 O95219,P11279,Q00535 3 +Ion homeostasis 0.3870724822735485 1.6677445116152223 0.0953664552212862 1.0 0.2237725769834229 109 P30519,P42858,Q93050,Q9HD20,P55011,P30536,Q9Y5X3,P09601,P20020,O95202,P06576,Q8N511,Q15043,O43819,Q9UM00,Q8NE86,P09874,Q15904,P0DP25,P50897,Q6YHU6,Q96A33,P09429,Q00535,Q9P2D1,O76024,Q9Y6M7,Q9Y487,P05067,P78417,O00203,Q07812,Q9UJZ1,O75503,Q92544,P16615,Q8IYU8,Q8NE01 38 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.5513418903150632 1.6676699159598012 0.095381270622163 1.0 0.2237725769834229 2 P51572 1 +Terpenoid metabolic process 0.5648411890564673 1.663481849244468 0.0962160211703884 1.0 0.2251516066812075 17 P37268,Q9HB40,P51648 3 +Detection of stimulus 0.5568891888997108 1.663357787205987 0.0962408376430643 1.0 0.2251516066812075 18 Q9UNS1,P30536,Q13432,Q8WTV0 4 +Organonitrogen compound catabolic process 0.3036221148982689 1.6616259650787475 0.0965877938733938 1.0 0.2257603286564799 395 P55786,P30519,Q16740,Q9Y5X3,P06280,Q9UIQ6,Q16850,P09601,Q8TCT9,Q96S82,P61289,Q9P0J0,Q9BQT8,Q13867,Q8WW12,Q96HY6,Q68CQ4,Q8N511,Q13510,P42892,Q96RL7,P49902,P16278,P60900,O43708,Q13190,A8MXV4,Q9UBN7,P50897,P49721,Q9H773,Q96A33,Q9UPU5,O95470,P21964,P04062,P13473,Q8WTV0,P28072,O95628,Q9NRN7,P14735,Q13315,Q9NUJ1,O76024,O75844,Q13126,Q8NCC3,A4D1P6,Q9UBU6,Q9BUN8,P28074,P48729,Q9H3F6,Q7L5D6,Q6ZXV5,Q16763,O14965,O60502,P42345,Q9UHG3,Q70CQ2,P17900,O14773,P10619,O75503,P46379,Q9NZ08,P54802 69 +Deoxyribonucleoside catabolic process 0.5501750291715428 1.6610162027971658 0.0967101926018436 1.0 0.2257603286564799 2 Q9Y315 1 +Purine deoxyribonucleoside monophosphate metabolic process 0.5501750291715422 1.6610162027971591 0.0967101926018449 1.0 0.2257603286564799 2 P55263 1 +Damp metabolic process 0.5501750291715422 1.6610162027971591 0.0967101926018449 1.0 0.2257603286564799 2 P55263 1 +Deoxyribonucleoside monophosphate catabolic process 0.5501750291715339 1.661016202797115 0.0967101926018538 1.0 0.2257603286564799 2 O43598 1 +Low density lipoprotein particle clearance 0.6412971215118295 1.6603235245405028 0.0968493856909897 1.0 0.2260048609190166 10 P09601 1 +Lipid droplet formation 0.6147631522222301 1.6597800202463118 0.0969587145431982 1.0 0.2261795537975353 4 Q14534 1 +Cellular hyperosmotic response 0.6399349214187635 1.6594890082806428 0.0970172937428335 1.0 0.2262357787990311 5 Q92974,O95202 2 +Multicellular organismal signaling 0.4891982578565311 1.655856371231898 0.0977509087359367 1.0 0.2276229464603324 28 P04062,Q99959,P0DP25,O75844,P20020,P16615 6 +Cellular response to osmotic stress 0.6402189053686916 1.6547441105986842 0.0979764152674249 1.0 0.2279054367191927 10 Q92974,O95202,P30536,P42574 4 +Selective autophagy 0.4831422371125391 1.6497503717367576 0.0989940030139593 1.0 0.2298650558307151 30 P42858,Q7Z6Z7,O15269,P50851,Q9UBN7,P27544,Q14457,P21796,P05141,Q63HN8,Q96HY6,P12235,Q99623 13 +Retrograde transport endosome to golgi 0.4645807774175104 1.6480519518864511 0.0993420108271472 1.0 0.2305099982488472 36 O95249,O15260,Q9BVK6,Q9Y5X3,Q13190,Q9Y5X2,P53367,Q8NBN3,O75503 9 +Layer formation in cerebral cortex 0.6120894124684239 1.645934081459048 0.0997773312291809 1.0 0.2312704858151273 4 P43034,Q96N66 2 +Development of secondary sexual characteristics 0.6115570320072835 1.6431753295988425 0.100346662652027 1.0 0.2322662435000358 4 Q07812 1 +Regulation of microtubule based movement 0.6617502034615917 1.6410513726146252 0.1007867516467571 1.0 0.2328741775725422 6 P11279,Q9UBN7 2 +Negative regulation of lymphocyte differentiation 0.6359570915811461 1.6395546303418134 0.1010978030069873 1.0 0.2332643401307492 5 P32119,P09429 2 +Vitamin metabolic process 0.4862618923167766 1.6336095042468646 0.1023408708956052 1.0 0.2355527165264685 28 O14678,P04062,P78417,P38435,P00374,Q8N0U8,Q9H2D1 7 +Positive regulation of meiotic cell cycle 0.5771864872768151 1.6331649589974957 0.1024343075379856 1.0 0.2356851073156598 3 Q9H6S0 1 +Positive regulation of ubiquitin protein transferase activity 0.6290262433087688 1.63129527435214 0.1028280300471238 1.0 0.2364252043339966 11 Q16763,Q9BTE7,Q92564,Q96GG9,Q96GX5 5 +Positive regulation of oxidoreductase activity 0.6412847966392701 1.627148537026782 0.1037055546049141 1.0 0.2381924568839505 9 P0DP25,P00374,Q8WTV0 3 +Metal ion export 0.6471014282296843 1.6255761730656368 0.1040398473313184 1.0 0.2387778568747721 8 P0DP25,O95202,P20020 3 +Reactive oxygen species metabolic process 0.4415186198831931 1.6248919777572337 0.1041855778559985 1.0 0.2387778568747721 44 Q15067,Q13546,Q13423,Q9BSK2,P30536,P52789,Q9UBN7,P42785,P32119,P00374,Q9P0J0,P00403,O75027,P18085,Q8IXJ6 15 +Cranial nerve development 0.6330063727865548 1.624747160684936 0.1042164440243316 1.0 0.2387778568747721 5 Q9H061,Q9P2D1 2 +Eye photoreceptor cell differentiation 0.658253277639322 1.624058976732343 0.1043632221636001 1.0 0.2387778568747721 6 P54802,Q8NBN7,Q15555 3 +Leukocyte degranulation 0.6276250738735053 1.6239003168738757 0.10439708493961 1.0 0.2387778568747721 11 P09601,Q99584 2 +Regulation of lipid metabolic process 0.4229759500612384 1.6234475421508794 0.104493768641787 1.0 0.2388111729928774 54 Q13510,P42345,Q8WTV0,P49748,P30536,P07602,Q8NCG7,Q9UBM7,Q8TBX8,O75844,Q9NZJ7,P16435,Q96G23,Q99623 14 +Endoplasmic reticulum tubular network organization 0.6272548533463891 1.6219456791566904 0.1048149796547142 1.0 0.2388111729928774 11 Q8NHH9,O95197,Q15041,Q9NQC3 4 +Golgi disassembly 0.6324421070836502 1.6219135849736075 0.1048218523446866 1.0 0.2388111729928774 5 Q13190 1 +Ovulation cycle process 0.6577705739424345 1.6217116319723908 0.1048651070311357 1.0 0.2388111729928774 6 O95470,P42574 2 +Amyloid precursor protein biosynthetic process 0.6572618765978973 1.619237420917617 0.1053961893711152 1.0 0.239477075710962 6 Q9Y287 1 +Organelle transport along microtubule 0.4607420128914467 1.6161743854354134 0.1060566151693109 1.0 0.2406443667845846 36 P42858,Q92572,P78537,Q9BQS8,Q9Y678,O14617,Q5SNT2,P11279,P62820,Q14204,O75381,Q9UBN7,P43034,O94901,Q9UPW5,Q9UBK9,Q9Y496,O00203,Q9Y2T2 19 +Male meiotic nuclear division 0.6564276297309487 1.6151787746452435 0.1062719856511495 1.0 0.2410496957631675 6 O15360 1 +Calcium mediated signaling 0.5491349911218926 1.6145854735381169 0.106400493318788 1.0 0.2412577875459182 18 P42345,P42858,P78417,P0DP25,O75844,P16615 6 +Liver regeneration 0.6321505636681355 1.6129134098212985 0.1067633213958023 1.0 0.2417222616061797 10 P09601,P04818,P62841 3 +Regulation of clathrin dependent endocytosis 0.655941810282941 1.6128146596496973 0.106784780233883 1.0 0.2417222616061797 6 P50570,Q13432 2 +Negative regulation of protein secretion 0.6445552548222576 1.612792845800883 0.1067895209381766 1.0 0.2417222616061797 8 Q16850,Q8N5M9 2 +Regulation of pattern recognition receptor signaling pathway 0.5267920741823308 1.6106531197293252 0.1072553489820329 1.0 0.2424454061992309 21 P09429,Q9NUD5,O43657,Q9NPR9,Q9NQC3 5 +Golgi organization 0.4142780813281965 1.6100499791187624 0.1073869458171967 1.0 0.242656039411999 62 P42858,Q9Y3B3,Q9H4A6,Q8TBA6,P62820,Q8NHH9,Q7Z6Z7,Q9BVK6,Q13190,Q96GC9,P49755,O15260,P06493,Q9BTU6,P48729,Q14789,Q9P2W9,Q12907,P50570,Q15363 20 +Oligodendrocyte development 0.6435577784111702 1.6077814657934328 0.1078830490621265 1.0 0.2434417358822814 8 P49770,Q96P11,Q92542 3 +Cristae formation 0.6362492057226173 1.6014382471901452 0.1092798871832276 1.0 0.244852742257019 9 Q9Y512,Q5XKP0,Q6UXV4,Q9BUR5,O95202 5 +Positive regulation of ubiquitin protein ligase activity 0.603006986318149 1.5987885882840702 0.10986758554436 1.0 0.2458067154251928 4 Q16763 1 +Regulation of regulated secretory pathway 0.5382897972663464 1.5963530210077286 0.1104099985797666 1.0 0.2469145344638406 19 Q00535,P0DP25,P09601,P16615,P11279 5 +Glycoside metabolic process 0.6352011454260454 1.5960807535018464 0.1104707651336533 1.0 0.2469145344638406 9 Q9BTY2,P04062,Q9NUJ1 3 +Estrogen metabolic process 0.6520015083146136 1.5936245084151972 0.1110201617711958 1.0 0.2477428629392903 6 O95470 1 +Sulfur compound catabolic process 0.6283291415566157 1.59305311410222 0.1111482762104953 1.0 0.2477428629392903 10 P16278 1 +Meiotic cell cycle phase transition 0.6018474612575699 1.5927575158509022 0.1112145991779995 1.0 0.2478065194587549 4 O95067 1 +Membrane protein proteolysis 0.6213329433955636 1.5906394998012536 0.1116907296740163 1.0 0.2486579604204287 11 Q8TCT9,Q16740 2 +Divalent inorganic cation homeostasis 0.4196224390472012 1.5903601926557906 0.1117536378304289 1.0 0.2486579604204287 54 P42858,Q9HD20,P20020,O95202,O14617,Q15043,Q9UM00,Q8NE86,P0DP25,Q96A33,Q6YHU6,P09429,Q00535,O76024,Q9P2D1,P05067,P78417,O00203,Q07812,Q9UJZ1,P16615,Q8IYU8,Q8NE01 23 +Folic acid containing compound metabolic process 0.5815589042627445 1.5899840165857908 0.1118384078807528 1.0 0.2486579604204287 14 Q9H2D1,P31939,P00374,Q9NRN7 4 +Regulation of lipoprotein metabolic process 0.6260844631113412 1.5899450676573177 0.1118471877918894 1.0 0.2486579604204287 5 P04062 1 +Regulation of natural killer cell activation 0.6009636833633205 1.5881588924218135 0.1122504139638489 1.0 0.2491837673987742 4 P11279 1 +Polyol biosynthetic process 0.607856215019406 1.587183770630473 0.1124710293732313 1.0 0.2495046973452144 12 P04062,P00374 2 +Triglyceride metabolic process 0.6261885021362863 1.5819148939717846 0.1136690003628779 1.0 0.2513126618535058 10 Q8NCG7,Q8WTV0 2 +Adult behavior 0.5168383068738023 1.5814290800603097 0.1137799627375846 1.0 0.2514732622041193 22 O75844,P05067,P50897,O15118 4 +Plasma lipoprotein particle clearance 0.6193867640423241 1.58033463411512 0.114030252307494 1.0 0.2518024355082907 11 P09601 1 +Early endosome to golgi transport 0.6438069682824926 1.5802745006884833 0.114044016813569 1.0 0.2518024355082907 7 O15260,Q9BVK6,Q13190,Q9Y5X2,P49257 5 +Autophagosome organization 0.479023358074032 1.5785904073239985 0.1144300363655386 1.0 0.2522303992713014 28 P62820,P04062,P50851,Q15042,Q7Z3C6,Q8TBX8,Q96GC9,P16615,Q86Y82,Q14457 10 +Histone serine phosphorylation 0.6229466072530725 1.5741387625408685 0.1154553728776783 1.0 0.2538934841901225 5 P54646 1 +Protein neddylation 0.6367697192662325 1.5736273671974463 0.1155736224806434 1.0 0.2540411338354729 8 Q96GG9,Q92564 2 +Xenobiotic metabolic process 0.5575085198659204 1.5725685342683111 0.1158187583695151 1.0 0.2542950167758158 16 P78417,O43169,Q06520,P07099,O15217 5 +Positive regulation of endoplasmic reticulum unfolded protein response 0.5660614303395854 1.5725125587554891 0.1158317289154089 1.0 0.2542950167758158 3 Q07812 1 +Positive regulation of ire1 mediated unfolded protein response 0.5660614303395854 1.5725125587554891 0.1158317289154089 1.0 0.2542950167758158 3 Q07812 1 +Negative regulation of macrophage migration 0.5344224037339698 1.570852708733973 0.1162168655607587 1.0 0.2546952167394102 2 P14174 1 +Negative regulation of macrophage chemotaxis 0.5344224037339698 1.570852708733973 0.1162168655607587 1.0 0.2546952167394102 2 P14174 1 +Negative regulation of jun kinase activity 0.5341306884480822 1.5691773151722632 0.1166066284697837 1.0 0.255156142964376 2 Q53EL6 1 +Oligosaccharide metabolic process 0.6461673587611981 1.5651606708446535 0.1175452406576669 1.0 0.2565895004231874 6 P17900,P10253 2 +Proteoglycan biosynthetic process 0.6401799879179455 1.5622897551351418 0.1182197443792825 1.0 0.2578125498892827 7 Q96L58,Q9UL01,Q7LGA3 3 +Proteoglycan metabolic process 0.6401799879179455 1.5622897551351418 0.1182197443792825 1.0 0.2578125498892827 7 Q96L58,Q9UL01,Q7LGA3 3 +Golgi to vacuole transport 0.6400712767765059 1.561750340258156 0.1183468146620563 1.0 0.2579623591765305 7 O14617,P11279,Q99523 3 +Response to mineralocorticoid 0.6391251393185718 1.5570548169514136 0.1194574712137119 1.0 0.2598209897594888 7 P0DP25,P09874,O95831,P20020 4 +Membrane to membrane docking 0.5631747884447016 1.556731023145639 0.1195343598261333 1.0 0.2599020772627857 3 Q13464,P26038 2 +Golgi to lysosome transport 0.6194163877086432 1.5563345033934597 0.1196285708679345 1.0 0.2600207625158617 5 P11279 1 +Cellular response to vitamin d 0.5942340846470808 1.5530922223957346 0.1204011039406487 1.0 0.2604919367156403 4 P20020 1 +Pteridine containing compound biosynthetic process 0.6374669952299321 1.5488219632287723 0.1214245242719194 1.0 0.262099967634296 7 P00374 1 +Export across plasma membrane 0.6374340421764289 1.548658299767447 0.1214638832026659 1.0 0.262099967634296 7 P0DP25,P20020,P08183 3 +Regulation of action potential 0.5738354533094437 1.545352643155064 0.1222609884483061 1.0 0.2636466007879674 14 P0DP25,P16615,P04062 3 +Negative regulation of nervous system development 0.5380589711177068 1.5445897494702685 0.1224455271792823 1.0 0.2638914281420917 18 P30536,Q96G23 2 +Reactive nitrogen species metabolic process 0.5455969216466348 1.5445508085335502 0.1224549525590779 1.0 0.2638914281420917 17 O43169,P30536,P06280,P16435 4 +Homeostatic process 0.3235010320901057 1.5434454750164062 0.1227227272659006 1.0 0.2643640611386691 310 Q6IAN0,P30519,P53985,Q9P035,P30536,Q9H9B4,Q07820,P09601,P42574,Q5BJF2,Q8N511,P06576,O43819,Q9UM00,P09874,P42785,Q15555,P50897,Q8NF37,Q6YHU6,P23786,Q96N67,P04062,Q8WTV0,Q00535,Q9Y487,O15118,P78417,O14773,Q15907,O75503,Q9NQC3,Q93050,Q9HD20,Q9UIQ6,O95202,Q9Y6C9,P13473,Q8N5M9,Q9H1E3,Q9NX40,P05067,P49748,P52789,P62847,P28340,P16615,Q8IYU8,P54646,P42858,Q9Y5X3,P20020,Q15382,Q9Y6B6,P0DP25,P32119,Q96A33,Q16625,O15260,P14735,Q9P2D1,P10253,Q15067,Q16836,Q07812,Q8NE01,Q9NUT2,P55011,Q15043,Q8NE86,Q15904,Q9BWH2,P09429,O95067,O76024,Q16763,P49327,Q6ZU35,P78527,O00203,O00767,P05141,Q9UJZ1 83 +Regulation of dna methylation 0.6249006341046557 1.5433130235764427 0.1227548452132771 1.0 0.2643640611386691 9 O75844,P09874,Q03164 3 +Anterior posterior axis specification 0.6245261950101187 1.5413910609483288 0.123221638301469 1.0 0.2651952740355001 9 Q5T9L3,Q15363,Q8N2A8 3 +Nuclear pore complex assembly 0.624364161720669 1.5405592784533937 0.1234240851614885 1.0 0.2654568491739388 9 Q9BTX1 1 +Regulation of anion transport 0.5990778417781962 1.539320438365285 0.1237260867143557 1.0 0.2657537946625512 12 Q13546,Q15041,P55011,Q15042,O43865,Q15907,P08183 7 +Purine deoxyribonucleoside triphosphate metabolic process 0.5599649839509907 1.5391624409535885 0.1237646443902402 1.0 0.2657537946625512 3 Q96DE0,Q9Y3Z3 2 +Golgi vesicle budding 0.6297587870312653 1.5382623441795067 0.1239844828635163 1.0 0.2660517254906456 8 Q15363,P49755,Q9H4A6 3 +Cellular response to abiotic stimulus 0.3951311058223546 1.5351228829787136 0.1247536463816134 1.0 0.2674398652584605 74 Q96MG7,P30536,P46934,Q9H2U1,O95202,P42574,Q92974,P09874,Q13315,O75844,Q9H1E3,P49327,Q13535,P50570,P27544,Q15907,Q07812,P28340,P29692 19 +Regulation of protein localization to endosome 0.6147868873626415 1.5329526014126365 0.1252875339164032 1.0 0.2684966680468446 5 Q8IZ07,P35241 2 +Positive regulation of response to endoplasmic reticulum stress 0.6326114634095126 1.524686727481387 0.127337253787779 1.0 0.2717356290586686 7 Q07812,P46379 2 +Vocalization behavior 0.5262543757293027 1.5238684723441318 0.1275415705969178 1.0 0.2719063633063596 2 Q15334 1 +Regulation of biomineralization 0.6322951170297267 1.5231129012645026 0.1277304616863497 1.0 0.2720439109334069 7 O75844,P20020 2 +Cellular iron ion homeostasis 0.5698034707889689 1.5219951921435275 0.1280102853816607 1.0 0.2723746733704467 14 Q8N511,P09601 2 +Cell recognition 0.4965333086010953 1.5207922412212722 0.1283119820867795 1.0 0.2729281123025761 24 P35613,P05067,Q8WTV0,P45880,P17931,Q9NQC3 6 +Bleb assembly 0.5879764502709776 1.520408285779001 0.1284083933067752 1.0 0.2730282221949849 4 Q9NR77 1 +Toll like receptor signaling pathway 0.5488882264378139 1.5201078608607554 0.1284838692682282 1.0 0.2730282221949849 16 P09429,O00203,P51812,Q9NPR9,Q9NQC3 5 +Positive regulation of cell killing 0.6316201276141988 1.5197542697139628 0.1285727463868151 1.0 0.2731286376789514 7 O15400,Q9NUQ9,P01889,P11279 4 +Regulation of gtp binding 0.6312908828674204 1.518115732159749 0.1289852258477237 1.0 0.2737390207027048 7 O75503 1 +Negative regulation of macroautophagy 0.6131624805639259 1.513942887436698 0.1300403254226201 1.0 0.2757106996520947 10 P09601,O15118 2 +Ribosome associated ubiquitin dependent protein catabolic process 0.6105966229280968 1.5117573819961143 0.1305955949009667 1.0 0.2762215713815472 5 Q8N3C0,Q9H1I8 2 +Cellular response to biotic stimulus 0.4378056390558235 1.508201723550047 0.1315029063171988 1.0 0.2774669039400189 39 P09429,Q9UM00,Q86UE4,Q8WTV0,P30536,O76024,P32119,O75844,Q9NUQ9,Q96A33,Q8IXJ6 11 +Regulation of cardiac muscle contraction by calcium ion signaling 0.6285795274365391 1.5046155367644034 0.1324229494820645 1.0 0.2790492596343313 7 P16615,P78417 2 +Positive regulation of calcium ion transport into cytosol 0.6222451055633887 1.500265383757147 0.133545672487001 1.0 0.2809547247723111 8 P0DP25,P42858,P78417 3 +Positive regulation of release of sequestered calcium ion into cytosol 0.6222451055633887 1.500265383757147 0.133545672487001 1.0 0.2809547247723111 8 P0DP25,P42858,P78417 3 +Response to osmotic stress 0.5234171825954961 1.500145641344455 0.1335766804248972 1.0 0.2809547247723111 19 Q92974,P55011,P30536,Q07812,P08183,O95202,P42574 7 +Response to arsenic containing substance 0.5659310744514382 1.4995263079197174 0.1337371490546504 1.0 0.2811069145741998 14 P09601,Q13535,P78417 3 +Positive regulation of pattern recognition receptor signaling pathway 0.6163075997586589 1.4991421047324651 0.1338367706209253 1.0 0.2812157825214576 9 P09429,Q9NQC3,Q9NUD5 3 +Endothelial cell migration 0.443323121746802 1.497485630284399 0.1342669418614843 1.0 0.2819390951984193 37 P09601,Q8WTV0,P42785 3 +Positive regulation of calcium ion transmembrane transporter activity 0.6097341819242494 1.4960003315105534 0.134653568787048 1.0 0.2825057395641913 10 P0DP25,P42858,Q96GC9,P78417 4 +Regulation of synaptic transmission gabaergic 0.5520863729209353 1.4959528274697602 0.1346659483932932 1.0 0.2825057395641913 3 P21359,P33176 2 +Regulation of multicellular organism growth 0.5649704400703994 1.4939470855156525 0.1351894502051531 1.0 0.2834227387368099 14 O95470,P05067,O75844 3 +Hyperosmotic response 0.6260540996521988 1.4920305043082327 0.1356911486949379 1.0 0.2841811063184287 7 Q92974,P55011,O95202 3 +Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator 0.5207117852975662 1.49190362844395 0.1357244113383047 1.0 0.2841811063184287 2 Q9UNS2 1 +Phosphatidylinositol 3 phosphate biosynthetic process 0.630790953956434 1.4898709107740498 0.1362581815135466 1.0 0.2848442775061781 6 Q01968,Q13315,Q14457 3 +Endothelial cell proliferation 0.5216136059893949 1.4884329469893445 0.1366367531700789 1.0 0.2855447051917382 19 P09601,Q8WTV0 2 +Positive regulation of release of cytochrome c from mitochondria 0.6301132578873194 1.4865440898625786 0.1371352638492164 1.0 0.286495256726698 6 Q96A26,O14737 2 +Purine deoxyribonucleotide catabolic process 0.550335570469812 1.486334674581375 0.1371906193979897 1.0 0.2865196831602828 3 Q96DE0,Q9Y3Z3 2 +Regulation of epithelial cell migration 0.4213620671024463 1.4860626249801263 0.1372625570532668 1.0 0.2865787144077432 47 P09601,Q9NQC3,Q8WTV0,P42785 4 +Regulation of cell killing 0.6077740658394607 1.4857323002563467 0.137349943412727 1.0 0.2866699518684206 10 O15400,P01889,Q9NUQ9,P04439,P11279 5 +Response to axon injury 0.5286413763887354 1.484787760400725 0.1376000551824838 1.0 0.2870093967283722 18 P30536,P00374 2 +Histone h3 k27 trimethylation 0.5808050729360007 1.4828663565562277 0.1381099216328163 1.0 0.2878898684099558 4 P16402,P10412 2 +Nerve development 0.6127851223915962 1.4809982500235097 0.1386070398170373 1.0 0.2887426651680632 9 P42892,Q9H061,Q9P2D1 3 +Response to abiotic stimulus 0.3300810666935987 1.4803106066599745 0.1387903739294995 1.0 0.289032619563465 236 P55786,P30519,Q9NXR7,Q92547,P42858,Q6PJG6,Q96MG7,P55011,Q9Y4P3,P30536,P46934,P09601,Q9H2U1,Q13426,P20020,Q7L576,O95202,P42574,Q9BRK5,Q8N511,Q92974,P09874,Q15904,Q15555,P49770,P08183,Q8IXJ6,P04062,Q13315,Q00535,O75844,P51798,Q9H1E3,P00403,Q96A26,Q9Y487,P22830,O75190,P05067,P42345,P11166,Q13535,P49327,P49748,P52789,P78527,Q15907,P27544,P28340,Q07812,P50570,Q92544,Q99623,O95391,Q9UNS1,P29692,O75592,Q13432,Q6P6C2 59 +Regulation of lipase activity 0.588235628771681 1.479980810709692 0.1388783677969529 1.0 0.289032619563465 12 P18085,Q99623,P50897,P16435 4 +Carbohydrate derivative biosynthetic process 0.3365405958190863 1.4797165408771011 0.1389489094439893 1.0 0.2890877437449137 162 Q8WVC6,Q8NBX0,Q9H4A6,Q9H9S5,P49915,Q8NAT1,Q8N4A0,P31939,Q2TAA5,P06576,O75964,Q16706,Q9UL01,Q9Y287,Q8TB61,P09874,Q7LGA3,O43292,P50897,Q86YN1,P24539,Q92643,P56385,Q10472,P04818,Q53GQ0,Q9NQX7,Q13126,P00403,Q6ZXV5,O15118,O60502,O60512,Q96L58,Q9BT22,O43505,Q9UJZ1 37 +Cholesterol efflux 0.6119317210141828 1.476599353247643 0.1397830651996894 1.0 0.2904548682205072 9 Q8WTV0 1 +Connective tissue replacement 0.517502917152869 1.4733689985022052 0.1406515648972508 1.0 0.2916131339196714 2 Q13464 1 +Positive regulation of connective tissue replacement 0.517502917152869 1.4733689985022052 0.1406515648972508 1.0 0.2916131339196714 2 Q13464 1 +Regulation of connective tissue replacement 0.517502917152869 1.4733689985022052 0.1406515648972508 1.0 0.2916131339196714 2 Q13464 1 +Positive regulation of tissue remodeling 0.517502917152869 1.4733689985022052 0.1406515648972508 1.0 0.2916131339196714 2 Q13464 1 +Positive regulation of nucleotide metabolic process 0.6270631865493091 1.47156285105189 0.1411389634791462 1.0 0.2921641281624985 6 P05067,P00403 2 +Regulation of leukocyte mediated cytotoxicity 0.6108678387633781 1.4711138439710036 0.1412603316971514 1.0 0.2922289711843341 9 O15400,P01889,Q9NUQ9,P04439,P11279 5 +Lipid storage 0.5261710992812554 1.4690603945556349 0.1418164088684794 1.0 0.2930163925507208 18 P17900,P04062,Q8WTV0 3 +Regulation of dna dependent dna replication 0.4948837010752736 1.4687271390654824 0.1419068133316128 1.0 0.2930163925507208 23 Q9Y248,P0CG13,Q9BRT9,O75844,Q14691,Q8WVB6,Q9UNS1 7 +Response to xenobiotic stimulus 0.3881406510373446 1.4678731790168218 0.1421386748790474 1.0 0.2933062844516695 79 P54646,Q13867,O15118,P08183,Q16836,Q13535,P78417,O43169,P50750,P30536,O15228,Q06520,P09601,P07099,P27544,O15217,P16435 17 +Negative regulation of calcium ion transport 0.6039660224134697 1.465764847961625 0.1427123606424281 1.0 0.2943050001683259 10 P21796,P78417 2 +Mitochondrial fission 0.5730106132611933 1.4654263738485855 0.1428046262096816 1.0 0.2943364868671535 13 Q9UDX5,Q8NE86,Q9NUQ9,O14965,Q8TB36 5 +Regulation of ion transport 0.3833027571631598 1.4636264235947154 0.1432960487469325 1.0 0.2948600413538324 91 Q13546,P42858,P55011,P30536,P46934,P17931,P21796,P20020,Q15041,P0DP25,Q96GC9,P08183,P20337,Q6YHU6,Q99959,Q00535,Q9P2D1,O75844,O76024,P05067,P78417,Q15907,Q07812,P50570,Q99623 25 +Pyrimidine deoxyribonucleoside triphosphate metabolic process 0.5763895864355564 1.4597087267764417 0.1443701424711125 1.0 0.2966089896694599 4 Q9H773 1 +Regulation of cyclic nucleotide phosphodiesterase activity 0.5756808000090552 1.4559885078178374 0.1453957965421932 1.0 0.2981221893085212 4 P0DP25 1 +Glycolipid catabolic process 0.6134907726419468 1.455877211797632 0.1454265662871954 1.0 0.2981221893085212 8 P17900,P04062 2 +Negative regulation of meiotic cell cycle 0.5142940490081725 1.4548144004097416 0.1457206504284456 1.0 0.2986317639323735 2 Q15645 1 +Cellular modified amino acid metabolic process 0.3971655305152899 1.4535254076215751 0.146077930531904 1.0 0.2991085589097096 64 Q9UHG3,Q9NRN7,P78417,O43708,Q9H7Z7,O60725,Q06520,P00374,P48651,Q8NCC3,P16435,O15217,P31939,Q9H2D1,Q8TB36,P23786 16 +Chemokine production 0.6074505909319251 1.4534817126733186 0.1460900535363638 1.0 0.2991085589097096 9 P05067,P09601 2 +Regulation of steroid metabolic process 0.5576138839731687 1.4511538661590022 0.1467370198925763 1.0 0.3001522208650518 14 Q13510,P49748,P30536,P16435 4 +Regulation of mitotic cell cycle spindle assembly checkpoint 0.6226590848158307 1.4499073850330824 0.1470843476680914 1.0 0.300675230342061 6 P14635,Q96SN8 2 +Axonal fasciculation 0.5434686347759948 1.4485579636366022 0.1474610676820602 1.0 0.3011831631933538 3 Q9NQC3 1 +Neuron recognition 0.6173391885732776 1.4485261982124324 0.1474699445605634 1.0 0.3011831631933538 7 P35613,P05067,Q9NQC3 3 +Fatty acyl coa metabolic process 0.5439326788725952 1.4485241657500645 0.1474705125480411 1.0 0.3011831631933538 15 P50897,A8MXV4 2 +Homologous chromosome pairing at meiosis 0.6119951779373722 1.448282012363972 0.1475381961712343 1.0 0.3012276425873178 8 Q9BTX1 1 +Metencephalon development 0.4547069666777141 1.4474962605908557 0.147757983003431 1.0 0.3015345805498289 31 P54802,O14949,P31939,P04062 4 +Regulation of t cell mediated cytotoxicity 0.5978099872264633 1.44690564731447 0.1479233512544182 1.0 0.3015345805498289 5 O15400,Q9NUQ9,P01889 3 +Positive regulation of t cell mediated cytotoxicity 0.5978099872264633 1.44690564731447 0.1479233512544182 1.0 0.3015345805498289 5 O15400,Q9NUQ9,P01889 3 +Regulation of mitochondrial membrane permeability 0.5298805767482778 1.446640990318278 0.1479974995265607 1.0 0.3015345805498289 17 Q07812,P12235,P52789,P45880 4 +B cell differentiation 0.5427814959427872 1.4416052024349444 0.1494137799726367 1.0 0.3035458898391462 15 P55327,Q5HYI8,Q13315,P78527,Q07812 5 +Regulation of retrograde protein transport er to cytosol 0.5421651590312331 1.4413781337343554 0.1494778843180348 1.0 0.3035821346007257 3 Q13438,P51572 2 +Carbohydrate catabolic process 0.4063506118458102 1.432024470454034 0.1521368182686955 1.0 0.3073307416842972 52 P05067,P16278,P17900,Q9BRR6,P52789,Q9NUJ1,Q14108 7 +Regulation of oxidative phosphorylation 0.6086222370772206 1.4311408128928984 0.1523898623896977 1.0 0.3075922107047668 8 P14406 1 +Positive regulation of interleukin 1 production 0.608429319835704 1.4301599148158417 0.1526711273135519 1.0 0.3080651714119088 8 P05067,P49755,Q99584 3 +Nervous system process 0.3678078367067637 1.4297460884592352 0.1527899072275707 1.0 0.3082100741553393 110 P42858,Q13641,Q14108,Q7L576,P42574,Q9Y5J9,Q15555,P50897,P43034,P04062,Q9Y5L4,Q00535,Q9P2D1,O75844,O76024,Q9Y6M9,O00264,P18085,Q9UQB8,P10253,P05067,P42345,P78417,P17900,O14773,Q99797,Q9ULX3,Q13432 28 +Intracellular protein transmembrane transport 0.4997499523244089 1.428567237381617 0.1531286563915526 1.0 0.3087718770356981 21 Q99595,Q15629,O60830 3 +Er associated misfolded protein catabolic process 0.6132214716183118 1.4279324754819676 0.1533112950772412 1.0 0.3089634310257133 7 P46379 1 +Negative regulation of mononuclear cell migration 0.50962660443409 1.4277921047339748 0.1533517060120006 1.0 0.3089634310257133 2 O94813 1 +Histamine secretion 0.53924715494603 1.425295160709216 0.1540718984283506 1.0 0.3093769461502886 3 P51809,O95219 2 +Regulation of histamine secretion by mast cell 0.53924715494603 1.425295160709216 0.1540718984283506 1.0 0.3093769461502886 3 P51809,O95219 2 +Histamine production involved in inflammatory response 0.53924715494603 1.425295160709216 0.1540718984283506 1.0 0.3093769461502886 3 P51809,O95219 2 +Histamine transport 0.53924715494603 1.425295160709216 0.1540718984283506 1.0 0.3093769461502886 3 P51809,O95219 2 +Organelle fusion 0.4248463199177358 1.4248693217865809 0.1541949791134671 1.0 0.3093769461502886 40 Q8N2A8,O95249,Q13277,O75396,O15400,O60343,Q7Z6Z7,Q9Y6C9,P02786,P06493,Q13190,Q8NAN2,Q07812,Q99536,Q9UJZ1,Q86Y82,Q8TB36 17 +Hindbrain development 0.4315700867882261 1.4247071110489409 0.1542418827052865 1.0 0.3093769461502886 38 Q5T9L3,Q9UKA9,P04062,O94788,O15228,Q00535,O95456,O14949,O95487,P31939,P54802,Q9BRK5 12 +Natural killer cell activation 0.5959417839182969 1.423611123568843 0.1545590740323716 1.0 0.309803468207937 10 Q5HYI8,P46379 2 +Embryonic axis specification 0.6170526931944293 1.4223018140879835 0.1549386524948977 1.0 0.3102555500981137 6 Q8N2A8 1 +Myeloid leukocyte differentiation 0.4489376654923956 1.4220900572717865 0.1550001088059136 1.0 0.3102839273899955 32 Q6IAN0,P05067,Q13546,P49327,P04062,P42345,P09874,Q15904,O00203,Q8N5M9,Q14739 11 +Positive regulation of oligodendrocyte differentiation 0.5928889274882566 1.4218822426011546 0.1550604390187206 1.0 0.3103100338032464 5 Q15382 1 +Amino acid transmembrane transport 0.5525206244244533 1.4214595705526585 0.1551831990090453 1.0 0.3103663980180906 14 Q15041,O60831,Q9Y619,Q96NB2,P30825 5 +Regulation of plasma lipoprotein particle levels 0.5518072650684465 1.417296458728894 0.1563962700990864 1.0 0.3122644646468248 14 P09601 1 +Mitochondrial outer membrane permeabilization 0.5887246362915735 1.4170044976924587 0.1564816124878487 1.0 0.3122644646468248 11 Q07812,P45880 2 +Response to toxic substance 0.4131890456346869 1.4092575484371157 0.1587590265534562 1.0 0.3154987075238581 47 P08183,P78417,Q15165,O43708,Q07812,P32119,P07099,P27544,P00374,Q13867 10 +Regulation of stress activated protein kinase signaling cascade 0.4493529484190326 1.404888870698333 0.160054326522169 1.0 0.3176879886988726 31 P05067,Q13546,P09429,P49327,Q96J02,O75844,P78318,P43034,O75915 9 +Glycolipid biosynthetic process 0.6031753893600802 1.4034260892110024 0.1604898177486702 1.0 0.3181674272105057 8 O43292,Q8NBX0 2 +Regulation of protein exit from endoplasmic reticulum 0.6077899677381484 1.4007332449194314 0.1612938573426596 1.0 0.3195683248437598 7 Q9Y6B6,Q9NR31,Q92544 3 +Negative regulation of leukocyte chemotaxis 0.534578348409702 1.3995350668158626 0.1616525903187835 1.0 0.3198017768629135 3 P14174,O94813 2 +Glycerolipid biosynthetic process 0.4068749245098778 1.3992561965598307 0.1617361700653663 1.0 0.3198017768629135 50 Q6IAN0,Q92643,Q9NPH0,Q8WTV0,P52429,O15228,Q13315,Q9NUQ2,Q8TBX8,O43292,Q9BTU6,P48651,Q8NF37,Q8NCC3,Q96N66 15 +Cellular response to xenobiotic stimulus 0.450904399762384 1.3978439103033555 0.162159945097378 1.0 0.3203171462158323 30 P54646,P78417,O43169,Q06520,P27544,P07099,O15217 7 +Regulation of programmed necrotic cell death 0.6071317809406387 1.3974346800166595 0.1622828964659919 1.0 0.3204635469785853 7 Q13510,P12235,Q92974 3 +Interstrand cross link repair 0.5879022304088037 1.3964919005167746 0.1625664179473771 1.0 0.3207389563032339 5 Q9H1E3 1 +Response to vitamin d 0.5879005472149688 1.396483324978851 0.1625689985773477 1.0 0.3207389563032339 5 P20020 1 +Protein localization to vacuole 0.4728830751311936 1.3926634552995818 0.1637215845136275 1.0 0.3225332533303408 25 Q96RL7,P13473,Q99523,O00203,P46934,Q14108,Q9NQC3 7 +Neuron maturation 0.6010287065097518 1.392492332844744 0.1637733617946808 1.0 0.3225332533303408 8 P05067,O75503 2 +Mammary gland epithelium development 0.6048453091472994 1.3859716609015271 0.1657555570666464 1.0 0.3255506331495346 7 Q07812,Q9NQC3 2 +Regulation of hyaluronan biosynthetic process 0.5023337222870619 1.385496045745772 0.165900840788181 1.0 0.3255506331495346 2 Q00610 1 +Hyaluronan metabolic process 0.5023337222870619 1.385496045745772 0.165900840788181 1.0 0.3255506331495346 2 Q00610 1 +Hyaluronan biosynthetic process 0.5023337222870619 1.385496045745772 0.165900840788181 1.0 0.3255506331495346 2 Q00610 1 +Positive regulation of synaptic transmission 0.5198670842784042 1.3839375625601231 0.1663775738601454 1.0 0.3261279778930114 17 O75955,P05067,Q13277,Q00535,Q92542 5 +Second messenger mediated signaling 0.4773239132921018 1.383884400634306 0.1663938540057608 1.0 0.3261279778930114 24 P42345,P42858,P78417,P0DP25,O75844,P16615 6 +Cartilage development involved in endochondral bone morphogenesis 0.5616624149152653 1.382259296789757 0.1668920989816458 1.0 0.326909239855988 4 O75844 1 +Neuron death 0.3806094485931729 1.3810388860193856 0.1672670046247637 1.0 0.3275458323926289 79 P05067,Q15392,P49327,P04062,Q9UMX5,Q13315,Q9UGN5,Q07820,P09601,Q07812,O76024,P50897,Q99720,Q01105,Q96A26,P42574 16 +Phosphatidic acid metabolic process 0.5933566839400233 1.3805750070993372 0.1674096723481291 1.0 0.3276283330414368 9 P52429,O15228,Q9NUQ2,Q9NPH0 4 +Polyamine biosynthetic process 0.5014585764294142 1.380414951092378 0.1674589193875311 1.0 0.3276283330414368 2 P52788 1 +Homologous chromosome segregation 0.581242706746088 1.3769039203447035 0.1685419549936884 1.0 0.3293389627770504 11 Q14674,Q9BTX1,Q13315,P46379 4 +Calcium ion transmembrane transport 0.4153595629129233 1.373666363497479 0.1695452839340789 1.0 0.3307241834647522 43 P42858,Q9UM00,Q8NE86,P78417,Q8IYU8,Q9P2D1,P0DP25,Q00535,Q07812,Q9UJZ1,P21796,Q96GC9,P20020,P16615,O95202,Q6YHU6 16 +Insulin receptor signaling pathway 0.4523033354042715 1.3734783418223102 0.1696036897454289 1.0 0.3307397955748899 28 P43490,P14735,Q9Y5X3,Q8TBX8,Q9H1E3,Q9UQB8 6 +Regulation of protein tyrosine kinase activity 0.5566400863459512 1.3727001076040584 0.1698455957381353 1.0 0.3310147903871826 13 O95684,Q13432 2 +C4 dicarboxylate transport 0.5913697490425252 1.3702746980333846 0.170601168207483 1.0 0.3319943255567923 9 Q9UBX3 1 +Synaptic vesicle recycling via endosome 0.528751554170041 1.367342219302052 0.171518064150054 1.0 0.3332844349874605 3 O00203 1 +Negative regulation of peptidyl threonine phosphorylation 0.5586434765968087 1.366347139533938 0.1718300317690815 1.0 0.3335942806120452 4 P0DP25 1 +Protein localization to axon 0.5284505398307693 1.3656779031985256 0.1720400828668193 1.0 0.3339032900834276 3 O14579,Q9Y2J2 2 +Response to hydrostatic pressure 0.4985414235706043 1.3634700228264642 0.1727344258140992 1.0 0.3347558482552036 2 P23634 1 +5 phosphoribose 1 diphosphate metabolic process 0.5579240692516989 1.362553704434076 0.1730232077630376 1.0 0.3352165011340575 4 P06737 1 +Regulation of synapse structure or activity 0.4361410707192452 1.361584253843217 0.1733291273374642 1.0 0.3357100748490083 34 Q14444,P05067,Q13641,Q00535,P46934,Q9H2U1,P50897,P43034,Q7L576,P18085,Q9UQB8,O00264 12 +Cellular response to oxygen levels 0.4164889241722311 1.360834162633746 0.1735661031845277 1.0 0.3358844042240513 41 P55786,Q8N511,P42345,Q9Y4P3,Q15904,P09601,Q99623,Q96A26,Q9Y487 9 +Dense core granule transport 0.4979579929988517 1.360079621124444 0.1738047291868738 1.0 0.3361351703284014 2 P33176 1 +Anterograde neuronal dense core vesicle transport 0.4979579929988517 1.360079621124444 0.1738047291868738 1.0 0.3361351703284014 2 P33176 1 +Positive regulation of sprouting angiogenesis 0.4976662777129663 1.3583842488758595 0.174341789623809 1.0 0.336975205747109 2 P14618 1 +Mammary gland development 0.5010197506417146 1.3540692286250458 0.1757142922841585 1.0 0.3389062508807214 19 Q13505,P52789,Q07812,P00403,Q99623,Q9NQC3 6 +Negative regulation of cell development 0.478479924813752 1.353571923773623 0.1758729892963946 1.0 0.3389062508807214 23 P30536,Q96G23 2 +Pulmonary valve morphogenesis 0.4967911318553268 1.3532974570667775 0.1759606212664564 1.0 0.3389062508807214 2 O94813 1 +Pulmonary valve development 0.4967911318553268 1.3532974570667775 0.1759606212664564 1.0 0.3389062508807214 2 O94813 1 +Mature b cell differentiation 0.496791131855316 1.3532974570667151 0.1759606212664763 1.0 0.3389062508807214 2 P16885 1 +Macrophage differentiation 0.593226990046415 1.35270732284402 0.1761491500952368 1.0 0.3391698130648309 8 P05067,Q13546,P04062 3 +Regulation of long term synaptic potentiation 0.5558377039136384 1.3515489646826306 0.1765196459803906 1.0 0.3397834898572376 4 P05067 1 +Lysosomal transport 0.4115119639873869 1.35095267018918 0.1767105945142184 1.0 0.3399516039877753 44 O15118,P07602,P13473,Q14108 4 +Antigen processing and presentation of peptide antigen 0.5276862312358868 1.350623570228393 0.1768160465186417 1.0 0.3400547764523232 15 Q03519,Q9Y6B6,P14735,Q9UIQ6,P50570,Q03518,Q9NZ08 7 +Sphingolipid mediated signaling pathway 0.4962077012835659 1.3499057088194546 0.1770462302664102 1.0 0.3402364038597672 2 P15311 1 +Interleukin 23 production 0.496207701283554 1.349905708819384 0.1770462302664328 1.0 0.3402364038597672 2 P16885 1 +Atp synthesis coupled electron transport 0.4229400247542529 1.3498439785607668 0.1770660346207109 1.0 0.3402364038597672 38 P03886,P13073,O14949,P00403,O43676,Q9UDW1,P47985 7 +Protein transmembrane import into intracellular organelle 0.5522171347239433 1.3475686380077505 0.1777971633063781 1.0 0.3412415869015658 13 Q99595,O60830 2 +Negative regulation of axon extension 0.5246923795770728 1.3448895681464097 0.1786608995407506 1.0 0.3423346193113943 3 Q9NQC3 1 +Positive regulation of wound healing 0.5964757023463563 1.343959737108409 0.1789614070501124 1.0 0.3427743003686041 7 P32119,P42345,Q16625 3 +Regulation of ire1 mediated unfolded protein response 0.6011239861444825 1.3436614054078904 0.1790579030138679 1.0 0.342859048607237 6 Q07812,Q96HY6 2 +Tetrahydrofolate metabolic process 0.5744568840304649 1.3404653614527848 0.1800940983834404 1.0 0.3442404525465005 11 P31939,P00374,Q9NRN7 3 +Modification of postsynaptic actin cytoskeleton 0.5766180222575203 1.338927108342401 0.1805944036436062 1.0 0.3446947285367493 5 Q9UQB8 1 +Regulation of calcium ion transmembrane transport 0.4708650011857326 1.3375854338479738 0.1810316153442561 1.0 0.345428746696426 24 P42858,P78417,Q9P2D1,P0DP25,Q07812,P21796,Q96GC9,Q6YHU6 8 +T cell differentiation in thymus 0.5844665979209717 1.3344512091058596 0.1820560268872049 1.0 0.346979857227371 9 Q5HYI8,O96005,P04062 3 +Mannosylation 0.5836912255443687 1.3304240469765571 0.1833785959392331 1.0 0.3487914047980427 9 Q9BT22,Q9H9S5,O43505,Q6ZXV5,Q2TAA5 5 +Positive regulation of peptidase activity 0.4128932649740821 1.3284729829283062 0.18402190306846 1.0 0.3499135693814067 41 P05067,P09429,Q9BXK5,O14737,Q07812,Q9NZJ7,P61289,Q9P0J0,Q96A26,Q96HY6 10 +Regulation of mitochondrial gene expression 0.571500108999643 1.3245695035686424 0.1853139763512383 1.0 0.3518606229215353 11 Q9Y2R0,Q567V2 2 +Pteridine containing compound metabolic process 0.5103386506546381 1.3240712211224015 0.1854793923526227 1.0 0.3519575058339803 17 Q9H2D1,P31939,P00374,Q9NRN7 4 +Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.5208637292092355 1.3236946443196662 0.1856044778721752 1.0 0.3519575058339803 3 P63241,P62081 2 +Purine deoxyribonucleotide metabolic process 0.5504962054874538 1.3233535080627272 0.1857178451323706 1.0 0.3519575058339803 4 Q96DE0,Q9Y3Z3,P55263 3 +Myelin assembly 0.5969386753562506 1.3229542009568382 0.1858506089046556 1.0 0.3519575058339803 6 Q9NR77,P18074,O15228 3 +Regulation of membrane permeability 0.4889616794836193 1.322851901353715 0.1858846333143671 1.0 0.3519575058339803 20 P42345,P52789,P45880,Q07812,P12235 5 +Protein targeting to vacuole 0.5033149024960862 1.3228286030823204 0.1858923828633791 1.0 0.3519575058339803 18 Q96RL7,P13473,Q99523,O00203,P46934,Q14108,O14617 7 +Peptidyl arginine methylation 0.5968847921289941 1.322687504664115 0.1859393205948873 1.0 0.3519575058339803 6 Q6P2P2,Q7L592,O14744 3 +Peptidyl arginine n methylation 0.5968847921289941 1.322687504664115 0.1859393205948873 1.0 0.3519575058339803 6 Q6P2P2,Q7L592,O14744 3 +Protein o linked glycosylation 0.5167019706560587 1.3226403941101856 0.185954994319782 1.0 0.3519575058339803 16 O60502,Q10472,Q9H9S5,O43505,Q6ZXV5,Q8N4A0 6 +Negative regulation of neuron apoptotic process 0.4435646462471831 1.3222427944695667 0.1860873149955109 1.0 0.3521063901385647 29 P09601,P50897 2 +Fat soluble vitamin metabolic process 0.5959128995602274 1.3178766641836617 0.1875449386727408 1.0 0.354047723696929 6 P38435,P04062 2 +Aerobic respiration 0.372289725667704 1.315487523309525 0.1883461077978656 1.0 0.3552535669357845 88 O75964,Q7KZN9,Q13423,Q9BSK2,P14406,P03886,P22695,O14949,P13073,P00403,P24539,O43676,Q9UDW1,Q15070,P47985 15 +Negative regulation of b cell proliferation 0.5488055556216158 1.314423434893628 0.18870374836865 1.0 0.3558258611480118 4 Q13315 1 +Regulation of defense response to virus 0.5149999058365511 1.3121393628589275 0.1894731167526275 1.0 0.356968875145203 16 O43657 1 +Embryonic heart tube development 0.5851421840221316 1.3114069475564836 0.1897203128564557 1.0 0.3572294671345947 8 P42892 1 +Learning 0.4944573735377706 1.3110403120936602 0.1898441445102854 1.0 0.3572930034881357 19 P05067,P42858,Q13641,P50897,O00264,P18085 6 +Regulation of microtubule binding 0.4892065344224086 1.3091729301905894 0.1904757795440295 1.0 0.358138127612585 2 Q7KZI7 1 +Regulation of blood circulation 0.4372932224294921 1.3084951119999366 0.1907054314040748 1.0 0.3584672130832251 31 P42892,P78417,Q99959,P0DP25,O75844,P20020,P16615 7 +Lymphocyte activation 0.3650523225648508 1.3079233881126762 0.1908992958332971 1.0 0.3587288600395463 101 P24390,Q5HYI8,P17931,P11279,P55327,P32119,Q9NUQ9,O96005,O15360,P09429,P04062,Q9UQ84,Q13315,Q9P2D1,P30825,P42345,P78527,O00203,Q07812,P05141,Q99623,P46379,Q9UJZ1,Q96FZ2 24 +Protein targeting to membrane 0.4240826989147582 1.307750046977749 0.1909581022948636 1.0 0.3587366353446594 36 P46379,Q15041,O76094,O60725,Q7L5D6,O43681,Q15629,P43307 8 +Telencephalon glial cell migration 0.5841425240736416 1.3062957952360288 0.1914519864728037 1.0 0.3593286681364379 8 P43034,Q96N66,O94901,Q9NQC3 4 +Cerebral cortex radially oriented cell migration 0.5841425240736416 1.3062957952360288 0.1914519864728037 1.0 0.3593286681364379 8 P43034,Q96N66,O94901,Q9NQC3 4 +Negative regulation of cation channel activity 0.5935670303173811 1.3062613768295794 0.1914636868170918 1.0 0.3593286681364379 6 P78417 1 +Positive regulation of mitochondrial calcium ion concentration 0.5469726842344727 1.3047392228478965 0.1919816607419264 1.0 0.3599381879395775 4 Q8IYU8 1 +Regulation of protein secretion 0.404648179814934 1.300354075858915 0.1934796421363906 1.0 0.3619055744962806 45 Q5T9L3,Q16836,P55011,Q9H4A6,Q16850,Q96KC8,P53367,Q8N5M9,P49755 9 +Positive regulation of epithelial cell migration 0.431349952296682 1.3002322510457236 0.1935213801181428 1.0 0.3619055744962806 33 P42345,P09429,Q8WTV0,Q9UBN7,P09601,Q9NQC3,P06576 7 +Meiotic chromosome condensation 0.5688456334814701 1.2992020376208349 0.193874602423377 1.0 0.3623483739966392 5 Q9NTJ3,P42695 2 +Positive regulation of protein localization to early endosome 0.5458204036508403 1.2986495220370788 0.1940642345849967 1.0 0.3625995180372292 4 P35241 1 +Amino acid import 0.5825244938700447 1.2980210672251724 0.1942800957652632 1.0 0.3627962402992765 8 Q96NB2,Q15041,P30825 3 +Chromosome organization involved in meiotic cell cycle 0.499116867288431 1.2958481956819972 0.1950277898569106 1.0 0.3637783846051868 18 Q9BTX1,Q13315,P42695,P46379 4 +Anterior head development 0.4868728121353717 1.2955836660571765 0.195118959502726 1.0 0.3638450162707838 2 Q13206 1 +Response to steroid hormone 0.3732934327380377 1.2901848408828502 0.1969864881654506 1.0 0.366086219163358 76 Q9H7B4,O15118,P04818,P04062,P16278,P09874,P30536,Q9UBN7,P0DP25,P46934,O15173,P20020,P16435,Q96HY6,P42574,Q99623 16 +Multicellular organismal response to stress 0.5903193880870725 1.2901738196315615 0.1969903139082318 1.0 0.366086219163358 6 P30536 1 +Glial cell migration 0.5419942894479096 1.2893740360870254 0.1972680833419 1.0 0.3664986304896795 13 P30536,O94901,P43034,Q9NQC3,Q96G23,Q96N66 6 +Amyloid beta formation 0.5648774462248433 1.2889290991285804 0.1974227365706029 1.0 0.3665593869465599 11 O95197,Q9NQC3 2 +Positive regulation of dna catabolic process 0.514517694211116 1.2885315537014592 0.197560992279592 1.0 0.3665713461343298 3 Q13315 1 +Response to glycoside 0.4854142357059632 1.2870878077789405 0.1980636845365515 1.0 0.3672489115368327 2 P05023 1 +Peroxisomal transport 0.5896569397753609 1.2868913376599411 0.1981321649604452 1.0 0.3672721091724412 6 O14678,O75381 2 +Negative regulation of cysteine type endopeptidase activity 0.458212843661955 1.2854354578239893 0.1986401572438858 1.0 0.3680058474970013 25 Q15392,P51812,Q15418,P16435 4 +Regulation of secretion 0.3669718607111693 1.2827030794922365 0.1995961206159227 1.0 0.3692797108275936 94 Q5T9L3,Q16836,P55011,Q9Y5X3,Q9H4A6,Q9P2D1,Q16850,P09601,Q96KC8,P53367,Q8N5M9,P0DP25,P16615,P49755,P11279 15 +Negative regulation of cellular senescence 0.5133054909773306 1.2818108025647217 0.1999090237849572 1.0 0.3696260958232993 3 Q15554 1 +Leukocyte mediated cytotoxicity 0.5157935726827771 1.2786568119738342 0.2010179344125959 1.0 0.3709447934801615 15 O15400,P01889,Q9NUQ9,P04439,P11279 5 +Metal ion homeostasis 0.371166669797915 1.2764292118521086 0.2018038353972462 1.0 0.3721857132874451 81 P30519,P42858,Q9HD20,P55011,Q9Y5X3,P09601,P20020,O95202,Q15043,Q8N511,O43819,Q9UM00,Q8NE86,Q15904,P0DP25,Q96A33,Q6YHU6,P09429,Q9P2D1,O76024,Q9Y487,P05067,P78417,O00203,Q07812,Q9UJZ1,P16615,Q8IYU8,Q8NE01 29 +Regulation of cardiac conduction 0.5639561012517716 1.2741859903034047 0.2025975090364793 1.0 0.3731251345207346 5 P16615 1 +Positive regulation of vasculature development 0.4719642102625488 1.2722718591781146 0.2032765434934775 1.0 0.3739877195312847 22 P09601,P52789,Q86UE4 3 +Protein targeting to lysosome 0.5389601011650211 1.27207619884324 0.2033460468772554 1.0 0.3739877195312847 13 P46934,P13473,Q14108,O00203 4 +Oligosaccharide lipid intermediate biosynthetic process 0.5635148679724868 1.2719277036427408 0.2033988075882509 1.0 0.3739877195312847 5 Q9BT22,Q86YN1 2 +Skin development 0.4054707147873605 1.2719023168961503 0.2034078285594567 1.0 0.3739877195312847 42 O75844,Q15392,P04062 3 +Positive regulation of cysteine type endopeptidase activity 0.4389677014667194 1.2700913379908134 0.2040520967430112 1.0 0.374752269473171 28 P09429,O14737,Q9BXK5,Q07812,Q9NZJ7,Q9P0J0,Q96A26 7 +Cellular potassium ion homeostasis 0.5105489417486577 1.26652372255712 0.2053256418077202 1.0 0.3766695167856473 3 P55011 1 +Regulation of animal organ morphogenesis 0.5756170653959962 1.2626716778332605 0.2067071964957481 1.0 0.3788862076550556 8 Q99623,Q9Y5V3,Q8TAA9 3 +Regulation of reactive oxygen species metabolic process 0.4240636693757221 1.261399446909632 0.2071649675044768 1.0 0.3795132654283577 34 Q13546,Q9BSK2,P30536,P52789,Q9UBN7,P42785,P32119,P00374,P00403,O75027,P18085,Q8IXJ6 12 +Pattern recognition receptor signaling pathway 0.4212032627075017 1.259724713793524 0.2077686868528134 1.0 0.380327604017688 35 P09429,Q9NUD5,O00203,O43657,P51812,Q99623,Q9NPR9,Q9NQC3 8 +Regulation of metal ion transport 0.3798569431419891 1.2576884930181118 0.2085044353902285 1.0 0.38132834588369 63 P42858,P78417,P30536,Q99959,Q00535,P0DP25,P46934,P17931,O76024,P21796,Q96GC9,P20020,Q9P2D1,P50570,Q07812,Q6YHU6 16 +T cell mediated cytotoxicity 0.5836111094132747 1.2569202243259536 0.2087825243517613 1.0 0.3817305446632092 6 O15400,Q9NUQ9,P01889 3 +Diencephalon development 0.5741133456084812 1.254971592308893 0.209489072642639 1.0 0.3828090489225835 8 Q07812,O75569,O14949,O94788 4 +Meiosis i cell cycle process 0.4693997213945466 1.2544427585226632 0.2096811191915311 1.0 0.3830172562757188 22 O95067,Q9BTX1,Q13315,Q14674,P46379,O14777,O14965 7 +Positive regulation of cell migration by vascular endothelial growth factor signaling pathway 0.5081299488609505 1.253104441948094 0.2101676997059685 1.0 0.383621820715039 3 Q12965 1 +Hydrogen peroxide biosynthetic process 0.5079257729630218 1.2519716216436216 0.2105802048038292 1.0 0.3841767283396965 3 P00403 1 +Regulation of cellular response to vascular endothelial growth factor stimulus 0.5078381484524299 1.2514854510953888 0.2107574184372387 1.0 0.3843774818746971 3 Q12965 1 +Myeloid cell activation involved in immune response 0.5578413989610901 1.2510161321676927 0.2109285918127117 1.0 0.3845827784037273 11 P09601 1 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.5631990597353069 1.2507017398586675 0.2110433154645132 1.0 0.384657272020463 10 O43657 1 +Positive regulation of dna damage response signal transduction by p53 class mediator 0.5593423741816812 1.2505664304113389 0.2110927045865431 1.0 0.384657272020463 5 Q13535 1 +Cellular response to vitamin 0.5588142468324355 1.2478619544374467 0.2120816154666287 1.0 0.3856508793831346 5 Q8TB36,P20020 2 +Export from cell 0.3339917129173984 1.247806011632775 0.2121021066281214 1.0 0.3856508793831346 142 P53985,Q13277,O43768,P55011,Q9H4A6,Q16850,P09601,Q96A65,P20020,Q9Y678,P11279,Q9BRK5,P62820,P61026,Q8NE86,Q9HCU5,P0DP25,P50897,P08183,P43034,P20337,P49755,Q99584,O00443,Q5T9L3,Q9UPT5,Q15042,Q00535,Q96KC8,Q4KMQ2,P27824,P53367,Q8N5M9,Q9P2D1,Q96PC5,Q16836,O15498,Q15907,Q96KP1,P16615,O60645,O75592 42 +Synaptic vesicle budding 0.5069935032205165 1.2467988544743167 0.2124712606415888 1.0 0.3861081175104142 3 O00203 1 +Regulation of coagulation 0.534538781874629 1.238976976099281 0.2153540247053216 1.0 0.3896203777547065 4 P32119 1 +Amyloid beta metabolic process 0.5211552322448876 1.2376140033998149 0.2158592195724926 1.0 0.3902545475685142 14 O95197,P49755,Q9NQC3 3 +Immune system development 0.3109420361075879 1.2350970349991808 0.2167943927630069 1.0 0.3912554470051846 178 Q6IAN0,Q13546,P24390,P01889,Q5HYI8,Q9H9B4,P17931,Q9H2U1,Q13426,P42574,P55327,Q9NPH0,P09874,Q15904,P32119,Q14739,O96005,O15360,O95470,P09429,P04062,O95067,O95628,Q9UQ84,Q13315,Q9P2D1,O75844,Q8N5M9,P05067,P42345,P49327,Q9NUQ2,P78527,O00203,Q07812,Q03164,P05141,Q96FZ2 38 +Hypothalamus development 0.5791398405859088 1.2347412102090816 0.2169268333940608 1.0 0.3913868245069637 6 Q07812,O75569,O14949 3 +Cell activation 0.3354927000194896 1.2323150674227554 0.2178314135184718 1.0 0.3926949822824758 136 P24390,Q5HYI8,P09601,P17931,P11279,P42574,P55327,P32119,Q9NUQ9,O96005,O15360,Q9BWH2,Q99584,P09429,P04062,Q9UQ84,Q13315,Q9P2D1,Q15418,P30825,P05067,P42345,P78527,O00203,Q07812,P05141,Q99623,P46379,Q9UJZ1,Q96FZ2 30 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.520023285353261 1.230954802890941 0.2183397689386508 1.0 0.393287280750872 14 O43657,Q9NUD5 2 +Positive regulation of i kappab kinase nf kappab signaling 0.400290929862289 1.224647946675912 0.2207078944298988 1.0 0.396464605324116 42 Q5T9L3,Q86UE4,Q8TB61,P09601,Q9H2U1,O43657 6 +Regulation of nitric oxide metabolic process 0.5578560317546589 1.2223863786765197 0.2215615478552681 1.0 0.3976926421569832 10 P30536,P06280 2 +Detection of light stimulus 0.5526235732445429 1.2161507233441438 0.2239275110630307 1.0 0.4004939568262763 5 Q13432 1 +Regulation of alcohol biosynthetic process 0.5297301619950151 1.2135219297400128 0.2249303352129699 1.0 0.4014122544649194 4 P16435 1 +Regulation of cholesterol biosynthetic process 0.5297301619950151 1.2135219297400128 0.2249303352129699 1.0 0.4014122544649194 4 P16435 1 +Negative regulation of hormone metabolic process 0.4722870478413156 1.2105594844191918 0.2260642800167946 1.0 0.4031070123560344 2 P05023 1 +Cotranslational protein targeting to membrane 0.5160292978977279 1.2074492406165562 0.2272591820188867 1.0 0.4045780663070902 14 P43307 1 +Regulation of system process 0.3699241008364511 1.2056503934207436 0.2279523197809365 1.0 0.4051928146426389 68 P05067,P42892,P04062,P78417,Q9Y5X3,Q9UGN5,Q99959,P0DP25,O75844,P20020,P16615,Q9UQB8,P10253 13 +Long chain fatty acyl coa biosynthetic process 0.573265939581223 1.2055916300339746 0.2279749880616615 1.0 0.4051928146426389 6 Q53GQ0 1 +Associative learning 0.5381908223867647 1.2036054709534807 0.2287421039093091 1.0 0.4062261666719585 12 O00264,P05067,P50897,Q13641 4 +Very low density lipoprotein particle assembly 0.4708284714119072 1.2020516628774542 0.2293435124258869 1.0 0.4069637989558328 2 P35610 1 +Negative regulation of response to external stimulus 0.381155544871633 1.200139131531442 0.230085310147678 1.0 0.408059406807855 53 P80303,O43657,Q96G23 3 +Meiotic cell cycle checkpoint signaling 0.5267783223345881 1.197892395320385 0.2309589106746119 1.0 0.4087250193761606 4 O60921,Q08J23 2 +Cellular response to corticosteroid stimulus 0.5369528724846588 1.196734262006892 0.2314101481904396 1.0 0.4092837562481887 12 Q9H7B4 1 +Regulation of neurogenesis 0.3757784886453483 1.1956797738110685 0.2318215473186888 1.0 0.4096991633464144 61 Q14444,Q15154,Q15382,Q16706,Q96N67,P42345,O15031,P30536,Q9P2D1,P55209,Q9H2U1,P43034,Q7L576,Q9NQC3,Q96G23,Q9UQB8,Q8IXJ6 17 +Female meiosis chromosome segregation 0.4975196965275884 1.1942122576460092 0.23239494944547 1.0 0.410491428872456 3 P53350,P33981 2 +Cellular respiration 0.3535406020276675 1.1936389180695743 0.2326192434404106 1.0 0.4106930821226985 105 O75964,Q9NZ45,Q7KZN9,P04062,Q13423,Q9BSK2,P14406,P03886,P22695,O14949,P13073,P00403,P24539,O43676,Q9UDW1,Q15070,P47985 17 +Tail anchored membrane protein insertion into er membrane 0.557364391999318 1.1933799276607628 0.2327206124386074 1.0 0.4107349808558746 9 O43681,P46379,Q7L5D6 3 +Response to x ray 0.5016037505990771 1.1925467083930563 0.233046947534381 1.0 0.4110753063635177 15 P50570,Q9H1E3,Q13315,Q13426 4 +Intrinsic apoptotic signaling pathway in response to dna damage 0.4454805199421505 1.1919284330874171 0.2332893082745717 1.0 0.4110753063635177 25 Q13315,P78527,Q07812,P09601,P46379 5 +Photoreceptor cell differentiation 0.5661536570119815 1.1912569531698094 0.2335527273458244 1.0 0.4113185713481749 7 P54802,Q8NBN7,Q15555 3 +Regulation of calcium ion transport into cytosol 0.5246326156060004 1.1902766764240102 0.2339376647698001 1.0 0.4116650459156418 13 P0DP25,P42858,Q9P2D1,P78417 4 +Regulation of release of sequestered calcium ion into cytosol 0.5246326156060004 1.1902766764240102 0.2339376647698001 1.0 0.4116650459156418 13 P0DP25,P42858,Q9P2D1,P78417 4 +Antigen processing and presentation of peptide antigen via mhc class i 0.5129394623070731 1.189256346528196 0.2343388076889723 1.0 0.4122603903632805 14 Q03519,Q9Y6B6,P14735,Q9UIQ6,Q03518,Q9NZ08 6 +Potassium ion homeostasis 0.5239052525354541 1.1826783944964658 0.2369366300322881 1.0 0.4161611794089601 4 P55011,P05023 2 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.545854636239424 1.1814634437392268 0.2374186674151319 1.0 0.4167847232686185 5 O95373,Q96SN8,P42574 3 +Negative regulation of tissue remodeling 0.4670361726954523 1.1799299482845045 0.2380280774672603 1.0 0.4176310813743749 2 P11274 1 +Membrane raft organization 0.5583232064478719 1.1740455371996392 0.2403767864194197 1.0 0.4208517802786105 8 P50897 1 +Ire1 mediated unfolded protein response 0.5626582251024823 1.1736250234377827 0.2405452536449643 1.0 0.4210343970174062 7 Q07812,Q96HY6 2 +Regulation of dna directed dna polymerase activity 0.5432890902373964 1.1724908521232111 0.2410000427239234 1.0 0.4216055132909584 11 Q9Y248,Q8WVB6,Q14691,P0CG13 4 +Response to water 0.4934344908082951 1.171530476269089 0.2413856150862752 1.0 0.4220902194899376 3 Q15149,P23634 2 +Progesterone receptor signaling pathway 0.5434316811323718 1.1690453983457945 0.2423853409547249 1.0 0.4230736324412275 5 P46934,O95071 2 +Regulation of peptidase activity 0.3610727083697997 1.1689605772537026 0.2424195150836658 1.0 0.4230736324412275 85 P05067,Q15392,P09429,Q15041,Q9BXK5,O14737,Q07812,P49755,P51812,Q9NZJ7,Q9P0J0,P61289,P16435,Q96A26,Q96HY6,Q15418 16 +Regulation of mitochondrial membrane permeability involved in apoptotic process 0.531847762174418 1.168390696526859 0.2426492059551699 1.0 0.4233083463077874 12 Q07812,P45880 2 +Regulation of hydrogen peroxide metabolic process 0.5430360715661586 1.1670178121022672 0.2432031763730955 1.0 0.4237650672756912 5 P32119,P00403 2 +Female meiotic nuclear division 0.5309545474202846 1.163430531259852 0.2446548681863336 1.0 0.4259552255342853 12 O14965,O14777,Q13315,O95067 4 +Central nervous system development 0.3104948754616789 1.1612433001228624 0.2455429704218135 1.0 0.4270482300312589 201 Q15154,Q9UKA9,P14854,Q86XL3,P51812,P20020,P31939,P42574,Q9BRK5,Q15382,O15031,O15228,P0DP25,Q9H9T3,P49770,P50897,P43034,P24539,O95487,Q96N66,Q8IXJ6,Q5T9L3,Q96N67,P04062,Q13315,O94901,Q00535,P51648,Q9P2D1,O14949,Q96SN8,Q16352,Q9UQB8,P05067,O75569,P42345,P78527,O14773,Q07812,O75503,P46379,P54802,Q9NQC3 43 +Response to oxygen levels 0.3634153737804991 1.158665270678304 0.2465926522493413 1.0 0.4282606111455319 70 P55786,P30519,Q9Y4P3,P09601,P42574,Q8N511,Q15904,Q8IXJ6,Q13315,Q96A26,Q9Y487,P49327,P42345,P11166,P52789,Q92544,Q99623,O75592,Q6P6C2 19 +Nuclear pore organization 0.5406916881377335 1.1584652416605687 0.2466742281893963 1.0 0.4282606111455319 11 Q9BTX1 1 +Respiratory electron transport chain 0.380536779549261 1.15834088719615 0.2467249520229208 1.0 0.4282606111455319 51 Q7KZN9,P04062,P03886,P13073,O14949,P00403,O43676,Q9UDW1,P47985 9 +Lipoprotein biosynthetic process 0.5190295125762621 1.1582496508745834 0.2467621717069881 1.0 0.4282606111455319 13 O43292,P04062 2 +Regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.5455790424173833 1.1572714252108254 0.2471614842047114 1.0 0.4287268462467132 10 Q92974,P09601 2 +Regulation of membrane potential 0.3654461778738894 1.1557128926917146 0.2477986128494778 1.0 0.4293780030415298 68 P05067,P42345,P04062,Q9BSK2,P30536,Q99959,P0DP25,O75844,P16615,Q9UQB8 10 +Regulation of amyloid fibril formation 0.5405775335542928 1.1544173454375812 0.2483291072649145 1.0 0.4299650581216294 5 P05067,O15212 2 +Negative regulation of transforming growth factor beta production 0.462660443407256 1.1544054568734132 0.2483339790126448 1.0 0.4299650581216294 2 P08238 1 +Positive regulation of neurotransmitter transport 0.5185089604129428 1.1541020618760944 0.2484583281653158 1.0 0.4300668819363763 4 P20337,Q00535 2 +Cellular response to fatty acid 0.5404328298722123 1.1536757232863968 0.2486331404437871 1.0 0.4301425435254762 5 P11802 1 +Meiotic cell cycle 0.3682293599497672 1.1523393301832123 0.2491816611574733 1.0 0.430649948369019 65 Q8N2A8,O95067,Q9UQ84,Q9BTX1,Q13315,Q9BZD4,Q9H6S0,Q9H2V7,P42695,Q14674,P46379,O15360,O14777,O14965,Q96GX5,Q8IXJ6 16 +Regulation of endoplasmic reticulum unfolded protein response 0.5540868697727173 1.152321599137507 0.2491889445225792 1.0 0.430649948369019 8 Q07812,Q96HY6,O76024 3 +Tissue migration 0.373070018488974 1.1514283086445485 0.2495560732459967 1.0 0.430650719998533 59 P09601,Q9NQC3,Q8WTV0,P42785 4 +Vesicle cargo loading 0.5177884216723814 1.1511540139227014 0.2496688799911623 1.0 0.430650719998533 13 Q15363,P49755,Q9NR31,O95487,Q96PC5 5 +Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 0.5622276931304042 1.150792806525296 0.2498174848835606 1.0 0.430650719998533 6 P78417 1 +Hindbrain morphogenesis 0.5443494037322292 1.1507473387626113 0.2498361952238887 1.0 0.430650719998533 10 O15228,P04062 2 +Cytokine production involved in immune response 0.5177132656438276 1.1507243134713845 0.2498456706849154 1.0 0.430650719998533 13 P09601 1 +Immune response regulating signaling pathway 0.3689073933946402 1.149535133072242 0.2503353883761809 1.0 0.4312682642490154 64 P09429,Q9NUD5,O00203,Q07812,P17931,O43657,P51812,P49770,Q9UJZ1,Q99623,P46379,Q9NPR9,Q9NQC3 13 +Regulation of dna templated transcription in response to stress 0.5173075192642088 1.148404455693288 0.2508016351505615 1.0 0.4316182349483306 13 P09601,P51812 2 +Modification of synaptic structure 0.5531982057330876 1.147764389936804 0.2510658415588958 1.0 0.4318464095175554 8 Q9UQB8 1 +Perk mediated unfolded protein response 0.5386845277559402 1.144715671297625 0.2523269575662372 1.0 0.4337881832721113 5 Q15363,P57088 2 +Integrated stress response signaling 0.5386845277559402 1.144715671297625 0.2523269575662372 1.0 0.4337881832721113 5 Q15363,P57088 2 +Negative regulation of autophagosome assembly 0.4880836868334145 1.141823633786427 0.2535273364939518 1.0 0.4357376590029628 3 Q14457 1 +Regulation of multicellular organismal development 0.307719453572977 1.1397659176321744 0.2543838364994359 1.0 0.4368321288903634 190 Q13546,Q15154,P01889,P55011,P30536,Q13641,P09601,P17931,Q9H2U1,P20020,Q7L576,Q68CQ4,P57105,Q14444,Q15382,Q16706,O15031,Q9UGN5,P32119,P16435,P43034,O96005,O15360,Q96G23,Q8IXJ6,Q96N67,P09429,Q86UE4,O95628,P06493,Q00535,Q9P2D1,O75844,P55209,Q9UQB8,P42345,Q92896,P52789,P78527,O00203,P46379,Q9NZ08,Q9NQC3 43 +Positive regulation of amine transport 0.5598781509694308 1.1391282157858698 0.2546496805051488 1.0 0.4370942201084976 6 P55011,P20337,Q15041 3 +Regulation of cellular response to insulin stimulus 0.48093731255116 1.1384652472688104 0.254926262454592 1.0 0.437340165810989 17 Q9H1E3,Q9Y5X3,Q8TBX8 3 +Regulation of nervous system development 0.3633977698731943 1.132825838940389 0.2572873982798351 1.0 0.4408145972616914 68 Q14444,Q15154,Q15382,Q16706,Q96N67,P42345,O15031,P30536,Q13641,Q9P2D1,P55209,Q9H2U1,P43034,Q7L576,Q9NQC3,Q96G23,Q9UQB8,Q8IXJ6 18 +Water soluble vitamin metabolic process 0.45638059034756 1.132539240625364 0.2574077965802415 1.0 0.4409057585903275 21 Q9H2D1,O14678,P00374,P78417 4 +Cellular response to gamma radiation 0.5355015378210876 1.1304357225376331 0.2582926687913955 1.0 0.4421905798615022 11 O75844,Q13535 2 +Monocarboxylic acid metabolic process 0.3109442889509916 1.129988556055452 0.258481046658757 1.0 0.44239765993082 168 P54646,Q9BRR6,Q8N4Q0,P07099,P21796,Q13510,Q9H7Z7,A8MXV4,Q06520,Q8NCG7,Q9HB40,P16435,P23786,O95470,Q9BXW6,A1L0T0,Q9NRN7,Q53GQ0,Q9NUJ1,P51648,Q8NCC3,P05067,O15118,O14678,Q15067,Q15800,P49748,P52789 28 +T cell homeostasis 0.557868216841157 1.1291502730211451 0.2588344467851491 1.0 0.4427669120850951 6 Q07812,P49327,O95067,P42574 4 +Response to salt stress 0.5578372858869918 1.1289967281317943 0.258899213908947 1.0 0.4427669120850951 6 O95202 1 +Regulation of gliogenesis 0.5025500633797273 1.1280474034526533 0.2592999000775204 1.0 0.4432211368347719 14 Q15382,P30536,Q96G23 3 +Regulation of cardiac muscle cell action potential 0.5348845969442901 1.1271038128843889 0.2596985914573098 1.0 0.4437870200892882 11 P0DP25,P16615 2 +Carbohydrate derivative catabolic process 0.3974344175222246 1.1267458140369953 0.2598499662220961 1.0 0.4438188023187672 38 O60502,P04062,P49902,P16278,P17900,Q9BTY2,A8MXV4,Q9NUJ1,Q13126,P54802,Q9H773 11 +Dna unwinding involved in dna replication 0.479066894931302 1.126630745724229 0.2598986342052387 1.0 0.4438188023187672 17 Q9Y248,Q14691,Q14566 3 +Regulation of peptidyl threonine phosphorylation 0.5391187308071689 1.1229941581910203 0.261439975516228 1.0 0.4458339707218005 10 P0DP25,P05067 2 +Positive regulation of carbohydrate metabolic process 0.5560154574197447 1.119953357026133 0.2627336389619248 1.0 0.4474586397270051 6 P05067 1 +Mitochondrion localization 0.454421222614189 1.1190969713901788 0.2630987717690112 1.0 0.447964229462442 21 Q9UBK9,Q6PJG6,O75153,Q9UBN7 4 +Programmed cell death 0.2819079514167132 1.1173698224740096 0.2638362326293992 1.0 0.4488704585206424 449 P54646,Q15392,Q9NS69,P24390,P42858,Q9UHX1,Q6PJG6,Q9P032,P30536,P45880,Q86XL3,Q9H4A6,P09601,P51812,P21796,Q9P0J0,P61289,Q99720,Q96HY6,Q9Y5V3,P11279,Q13510,Q15041,Q9Y6C9,Q92974,O95197,Q9UGN5,Q9UBN7,Q96KA5,P32119,P50897,P16435,P12235,O95470,P09429,P04062,Q86UE4,O15269,Q9BXK5,O14737,Q9NQX7,Q13315,O76024,O75844,Q96A26,P12236,Q01105,Q15418,P18085,O14965,O95881,P05067,P42345,P49327,Q9UDX5,Q9NVI7,Q9UBK9,P52789,P78527,Q07812,P50570,Q9NZJ7,Q03164,P05141,Q99623,P46379,Q9NQC3 67 +Thymus development 0.5379257042008254 1.1166643249133394 0.2641378768950393 1.0 0.4491660665292331 10 O75844,P32119,Q13315 3 +Bradykinin catabolic process 0.5114339353685142 1.1166432680226053 0.2641468836842899 1.0 0.4491660665292331 4 P42892 1 +T cell apoptotic process 0.5375800639110682 1.114830500554693 0.2649230635101922 1.0 0.4501122520549368 10 Q07812,P49327,Q13546,P24390 4 +Positive regulation of attachment of spindle microtubules to kinetochore 0.5547613935084287 1.1137288381232278 0.2653955337158207 1.0 0.4507053551354077 6 Q14457,P14635,Q8IXJ6 3 +Positive regulation of phospholipase activity 0.5539018760377169 1.109462932362133 0.267230526683365 1.0 0.4532351295156994 6 Q99623 1 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.4547841306884553 1.108477385043974 0.2676557006379196 1.0 0.4535377622364364 2 Q13177 1 +Maternal process involved in female pregnancy 0.5410326433463727 1.108215053765064 0.2677689510162868 1.0 0.4535621725784394 9 Q15363,Q9BQE5 2 +Positive regulation of fatty acid transport 0.4544924154025892 1.1067770357653852 0.2683903391978033 1.0 0.4544320348369173 2 P14174 1 +Bone mineralization 0.5451911170137074 1.1067061520281056 0.2684209946705107 1.0 0.4544320348369173 8 O75844 1 +Cell maturation 0.4176314807703015 1.1036975493423122 0.2697243590589488 1.0 0.456403105761945 28 O75503,P05067,Q8N2A8,P04062 4 +Leukocyte migration 0.3795078320796041 1.1023016043148015 0.2703305721354603 1.0 0.4570713736789374 48 P35613,P05067,P04062,Q8NE86,P55011,Q9H4A6,P09601,Q8N5M9 8 +Tangential migration from the subventricular zone to the olfactory bulb 0.4536172695449312 1.1016763790176771 0.2706023896237526 1.0 0.4571814831902844 2 O94813 1 +Synaptic vesicle cytoskeletal transport 0.5522762304846535 1.101395362455743 0.2707246229364592 1.0 0.4571940078280649 6 Q92572,O14617,Q9Y2T2,O00203 4 +Positive regulation of dephosphorylation 0.4809236914118411 1.101176080006799 0.2708200301460601 1.0 0.4571960478051059 16 P0DP25,Q86XL3,P04062 3 +Axis specification 0.5297320196701482 1.099277643567271 0.2716469807839392 1.0 0.4581816558005129 11 Q5T9L3,Q15363,Q8N2A8 3 +Regulation of translation at synapse modulating synaptic transmission 0.5077485758488948 1.0971389776720708 0.2725806436724682 1.0 0.459105283310764 4 Q7L576,P35268 2 +Cellular response to insulin stimulus 0.3708810102712411 1.0962024149230525 0.272990203040679 1.0 0.4596771137677535 53 Q12965,P43490,Q9Y5X3,Q92572,P20020,Q7L576,Q15043,O60343,P61026,Q9BSK2,P09874,P14735,Q9H1E3,Q9BZF1,Q9UQB8,O14654,P11802,P78527,Q8TBX8 19 +Antiviral innate immune response 0.5290534112272012 1.095370419004718 0.2733543881397451 1.0 0.4599362807623095 5 Q99623 1 +Vesicle targeting 0.4419993744155689 1.0952045859182786 0.2734270170510704 1.0 0.4599405500869326 23 Q9Y6B6,Q14849,Q658Y4,Q15363,Q9NR31,P49755 6 +Dna dependent dna replication maintenance of fidelity 0.4854197747260425 1.0941631373436835 0.2738834355553008 1.0 0.4605902368308262 15 Q13535,P28340,Q9H1E3,Q9UNS1,Q07864 5 +Regulation of cellular response to heat 0.5334671137228787 1.0930108726874477 0.274389025998428 1.0 0.4612040954410054 10 O75190,P42345,Q13315,Q13535 4 +Regulation of snrna transcription by rna polymerase ii 0.4791362707907916 1.0921725785423653 0.2747572529119351 1.0 0.4613503310153833 3 Q4G0J3,Q6P1N0 2 +Snrna transcription 0.4791362707907916 1.0921725785423653 0.2747572529119351 1.0 0.4613503310153833 3 Q4G0J3,Q6P1N0 2 +Snrna transcription by rna polymerase ii 0.4791362707907916 1.0921725785423653 0.2747572529119351 1.0 0.4613503310153833 3 Q4G0J3,Q6P1N0 2 +Negative regulation of phosphatidylinositol 3 kinase signaling 0.4779690691567072 1.0856992963710157 0.2776120521021143 1.0 0.4656672509954178 3 Q10713,O95630 2 +Negative regulation of ion transmembrane transport 0.4783503242994059 1.0852170508469274 0.2778255340543385 1.0 0.4659062495437182 16 P0DP25,P46934,P21796,P78417 4 +L amino acid transport 0.5166263597843055 1.0838520949383723 0.2784303828164547 1.0 0.4663576122479871 12 O60831,Q9Y619,Q15041,P30825 4 +Regulation of heart contraction 0.4130702767283825 1.0820485065110188 0.2792309748724659 1.0 0.467307742186463 29 P78417,Q99959,P0DP25,O75844,P20020,P16615 6 +Cellular modified amino acid catabolic process 0.5442455928691992 1.080756327235869 0.2798055199155009 1.0 0.4680305433814727 7 Q9UHG3 1 +Positive regulation of protein dephosphorylation 0.4822769624473316 1.0750536774505304 0.2823506969546614 1.0 0.470847591719565 15 P0DP25,Q86XL3,P04062 3 +Amyloid fibril formation 0.5427957187728555 1.0734482316744496 0.2830700540185913 1.0 0.4711324442935724 7 P05067,Q13546,Q99471,O15212 4 +Entry into host 0.4015445743626031 1.0733906237353978 0.2830958896448576 1.0 0.4711324442935724 34 P35613,O15118,Q8WTV0,Q9BTY2,P14735,Q96KP1,Q14108 7 +Regulation of transcription elongation from rna polymerase ii promoter 0.4762685660583414 1.0723074007218167 0.2835819837810782 1.0 0.4718217488771388 16 P50750,Q8IXH7,P35269 3 +Phosphatidylcholine metabolic process 0.5037484822936072 1.0708767598697653 0.2842248467811472 1.0 0.4727714688410363 13 Q6IAN0,Q8NCC3,Q96N66,Q8WTV0 4 +Vacuolar localization 0.4577441981791363 1.0691455610550935 0.2850040844761188 1.0 0.473707396740702 19 P09601,Q99584 2 +I kappab kinase nf kappab signaling 0.3658215246615186 1.0688065201244783 0.285156860751635 1.0 0.4738413067237855 58 Q5T9L3,Q86UE4,Q8TB61,P09601,Q9H2U1,O43657,Q96HY6 7 +Regulation of carbohydrate catabolic process 0.4754017115626482 1.0669320668507984 0.2860025132885961 1.0 0.4750059458870584 16 P05067,Q14108 2 +Ribonucleotide catabolic process 0.5284251313217068 1.066270717023614 0.2863012827740476 1.0 0.4752615779315205 10 A8MXV4 1 +Lipid catabolic process 0.3519729053969057 1.0660269023574511 0.2864114809536184 1.0 0.4753242635350643 87 O95470,Q13510,Q8N2A8,O14678,P04062,A1L0T0,Q8WTV0,P17900,A8MXV4,Q06520,Q8NCC3,P50897,Q8NHP8,P23786 14 +Lysine metabolic process 0.5015748267732765 1.0644851745825596 0.2871089669559936 1.0 0.4761455723242772 4 Q9NRN7 1 +Regulation of dna damage response signal transduction by p53 class mediator 0.5131323689368993 1.0644518582936875 0.2871240520705829 1.0 0.4761455723242772 12 O75844,Q13535 2 +Cellular response to molecule of bacterial origin 0.4068737926316697 1.0634093348232712 0.2875963613212784 1.0 0.4766878815332733 31 P32119,P30536,Q86UE4,Q8WTV0 4 +Regulation of lipid kinase activity 0.5406729386744333 1.0627506572552368 0.2878950414660526 1.0 0.4770588479504449 7 Q8TBX8 1 +Histone h4 r3 methylation 0.446907817969661 1.0625951795095918 0.2879655740219007 1.0 0.4770588479504449 2 O14744 1 +Protein catabolic process 0.3032455960921432 1.0611992899606817 0.2885993420173245 1.0 0.4776672454746358 295 Q13546,Q16740,Q9Y5X3,Q8N3C0,Q9UIQ6,Q16850,P46934,Q8TCT9,Q96S82,Q6NTF9,Q9P0J0,P61289,Q8WW12,Q96HY6,Q68CQ4,Q8N511,Q96RL7,P60900,Q13190,Q9UBN7,P50897,P49721,Q96A33,Q9UPU5,P04062,P13473,O95628,P28072,P14735,Q13315,Q9NUJ1,O76024,O75844,A4D1P6,Q9H3F6,P28074,Q9UBU6,Q9BUN8,P48729,Q7L5D6,Q6ZXV5,Q16763,O14965,O60502,P42345,Q9UHG3,Q9H1I8,Q70CQ2,O14773,P10619,O75503,P46379 52 +Positive regulation of neuron projection development 0.4085609549071331 1.0611450419545685 0.2886239909032202 1.0 0.4776672454746358 30 Q9UQB8,Q9H2U1,O15031,Q14108 4 +Neuron development 0.3052096996587761 1.0608226182538512 0.2887705211434856 1.0 0.4777892485485509 203 P35613,Q13277,P30536,Q13641,P46934,Q9H2U1,Q9BPU6,Q14108,Q7L576,P42574,O75955,P42892,Q14444,O15031,Q9NR77,Q9UBN7,Q15555,Q9HCE1,P00374,P50897,P43034,P83731,O95487,Q96G23,Q96N67,P09429,P04062,O94915,Q9NQX7,Q00535,O14949,O00264,P18085,O14965,Q9UQB8,P05067,P50570,Q9NZJ7,O75503,P54802,Q9NQC3 41 +Mast cell activation 0.5361885265017031 1.0605678370132448 0.2888863457184576 1.0 0.4778603984382452 8 P09601 1 +Vasoconstriction 0.5221901092802219 1.0602347089314113 0.2890378343017388 1.0 0.4778722183042725 5 P42892 1 +Regulation of cellular respiration 0.468497202565272 1.0597441359881852 0.2892610176985424 1.0 0.4778778444455778 17 P14406,Q9BSK2,Q9NZ45 3 +Tetrapyrrole biosynthetic process 0.5016404303963947 1.058827047348608 0.2896785532940806 1.0 0.4783623387482456 13 O00264,P30536 2 +Regulation of systemic arterial blood pressure 0.5356757246522243 1.0579410788579544 0.2900823056158961 1.0 0.4786189254813959 8 P42785 1 +Mitochondrial outer membrane permeabilization involved in programmed cell death 0.5116519252880636 1.056233508586556 0.2908615452635126 1.0 0.4795561457334597 12 Q07812,P45880 2 +Myotube differentiation 0.4791237909423397 1.055884160858916 0.291021141371262 1.0 0.4795782847007085 15 Q9H7B4,O75955,P42345,Q8IV08 4 +Negative regulation of transmembrane transport 0.44928782083673 1.0556925767082803 0.2911086897244599 1.0 0.4796021144795144 20 P0DP25,P46934,P21796,P78417 4 +Response to nutrient 0.3993822137487207 1.05528393219778 0.2912954874838684 1.0 0.4796825958653182 34 P42345,P53985,P04818,O94788,O15228,P30536,P02786,Q96C86,P09601,P20020,P16435,Q8TB36,Q14457 13 +Response to molecule of bacterial origin 0.3806900742569233 1.0544101882667634 0.291695159734701 1.0 0.4800861896611759 43 P51812,P30536,Q86UE4 3 +Er nucleus signaling pathway 0.5007837366647812 1.0539307956788972 0.291914602356877 1.0 0.4802064729671163 13 P57088,O76024,Q15363,P16615,Q96A33 5 +Head development 0.3077748971319064 1.051442010723959 0.2930556296203943 1.0 0.4818419046777819 166 Q15154,Q9UKA9,P14854,P20020,P31939,P42574,Q9BRK5,O15031,O15228,P0DP25,P50897,P43034,P24539,O95487,Q96N66,Q8IXJ6,O95470,Q5T9L3,Q96N67,P04062,Q13315,O94901,Q00535,Q9P2D1,O14949,Q96SN8,Q16352,Q9UQB8,P05067,O75569,P78527,Q07812,O75503,P46379,P54802,Q9NQC3 36 +Lactation 0.5207294341677182 1.0506790650226456 0.2934060142128465 1.0 0.4822971606374495 11 Q13505,P00403 2 +Ovarian follicle development 0.5295885938116107 1.048569604116722 0.2943762515735857 1.0 0.4837708396759002 9 Q07812,Q13315 2 +Vesicle localization 0.3586514531239906 1.0474072918741608 0.2949117700390555 1.0 0.4842870457948655 65 P42858,Q12965,Q92572,Q9BQS8,O14617,P62820,Q9BVK6,Q9Y6B6,Q14204,Q9HCU5,Q14849,P43034,P49755,O00560,Q00535,Q658Y4,O94832,O15498,O00203,P50570,Q15907,Q15363,Q9NR31,Q9Y2T2 24 +Cd40 signaling pathway 0.5195982817453992 1.0469757300014169 0.2951107719660295 1.0 0.4844925908534115 5 O15360 1 +Regulation of tube size 0.4992304526023207 1.0450544351167128 0.29599781149152 1.0 0.4855844097518386 13 P42892,Q9HB40 2 +Ethanol metabolic process 0.4964472846725952 1.037390980384098 0.2995536801480858 1.0 0.4895316559562883 4 Q06520 1 +Positive regulation of dendritic spine morphogenesis 0.5316254273680551 1.0372008800041943 0.2996422480465379 1.0 0.4895316559562883 8 Q9H2U1,Q9UQB8 2 +Regulation of b cell differentiation 0.4425320886814587 1.0371367030348575 0.2996721520841832 1.0 0.4895316559562883 2 O15347 1 +Response to amine 0.5176256106076723 1.0368884356931076 0.2997878540089054 1.0 0.4895987799916469 5 P0DP25 1 +Endoplasmic reticulum unfolded protein response 0.4379570184807057 1.0351415439993366 0.3006028135260128 1.0 0.4905634574378752 22 P57088,Q9Y4P3,O76024,Q15363,Q07812,Q9BUN8,Q96HY6 7 +Peptide transport 0.3918868500652063 1.032422867708077 0.3018740638816963 1.0 0.4920780215985215 36 Q03519,Q16836,Q8NE86,Q9P2D1,Q15907,Q8N5M9,Q03518 7 +Regulation of aerobic respiration 0.5073490627840924 1.0323550118543334 0.3019058389143016 1.0 0.4920780215985215 12 P14406,Q9BSK2 2 +Biomineralization 0.4965213764442883 1.0295771749698466 0.3032085345068744 1.0 0.4938387728925026 13 O75844 1 +Calcium ion transport into cytosol 0.4578521050134669 1.0295700320648489 0.3032118890557593 1.0 0.4938387728925026 18 P42858,P78417,Q9P2D1,P0DP25,O95202 5 +Very long chain fatty acid catabolic process 0.5158942350410645 1.0280383715556525 0.3039317782737276 1.0 0.4945202898666503 5 Q15067,O14678 2 +Pigment biosynthetic process 0.4369082165128949 1.0278180217810071 0.3040354372697367 1.0 0.4945663211115548 22 O00264,P30536,Q7KZN9 3 +Epithelial cell proliferation 0.3689224818277095 1.0276135379383562 0.3041316534703162 1.0 0.4945838646682739 50 P57105,P09429,Q8WTV0,Q07812,P09601,Q99623,Q15418,Q9Y5V3,Q9NQC3 9 +Purine nucleotide catabolic process 0.5064693423667281 1.0274747609570378 0.3041969640050523 1.0 0.4945838646682739 12 A8MXV4 1 +Protein destabilization 0.5064249109023565 1.0272282946186104 0.304312977728852 1.0 0.4946499281289886 12 Q68CQ4,P42858,Q9UBN7,Q9BUN8 4 +Mitochondrial atp synthesis coupled proton transport 0.520859514288415 1.026174987203499 0.3048091091888047 1.0 0.4953336737238576 10 P24539,O75964,Q9UJZ1,P56385 4 +Negative regulation of cell aging 0.4940391379936645 1.0246765048282298 0.3055158526870238 1.0 0.4962363924089729 4 Q15554 1 +Action potential 0.4223516405036109 1.021469307639664 0.3070321433323095 1.0 0.4983291923192222 25 P0DP25,P16615,P04062,Q99959 4 +Long term synaptic potentiation 0.5279778160489998 1.01853489634075 0.3084238257273473 1.0 0.5003081792839178 8 P05067 1 +Response to increased oxygen levels 0.519310759941235 1.0179727887746364 0.308690887885735 1.0 0.5005262185090669 10 Q8N511,Q15904,Q9Y487 3 +Connective tissue development 0.4166121164640033 1.0151686894461125 0.3100254230196393 1.0 0.5021937363255673 26 P04818,P43490,Q92896,O75844,O15173,P16435,Q96HY6,Q15043 8 +Calcium ion regulated exocytosis 0.5186603220082532 1.0145287711239763 0.3103305079572269 1.0 0.5024398700259864 10 Q9BRK5,P16615,Q00535 3 +Positive regulation of endothelial cell migration 0.4391522093365536 1.0143109680786035 0.3104343920727772 1.0 0.5024840850472532 21 P09601 1 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.4721130507891165 1.013283300346102 0.3109248617761468 1.0 0.5031508508771502 15 Q96A26,Q9BXK5,Q9NZJ7 3 +Negative regulation of interleukin 12 production 0.4642544499562421 1.0097492671946176 0.3126154318905088 1.0 0.5050209979985757 3 P32121,Q07021 2 +Positive regulation of amino acid transport 0.5123132937215759 1.009745187338977 0.3126173870573323 1.0 0.5050209979985757 5 P55011,Q15041 2 +Sensory perception of mechanical stimulus 0.4485004186719086 1.008140187119118 0.3133871673568051 1.0 0.5058909205892634 19 Q9Y5J9,Q9Y5L4,Q9P2D1,O76024,Q9Y6M9,Q14108 6 +Single strand break repair 0.4905640331931004 1.006342348969484 0.3142509156140152 1.0 0.5068656852571167 4 Q15554,P09874 2 +Regulation of calcium ion dependent exocytosis 0.5115821770578022 1.0060122823441917 0.3144096618268053 1.0 0.5068983361213433 5 P16615,Q00535 2 +Small molecule metabolic process 0.2802613166256454 1.0041032822311695 0.3153288335456834 1.0 0.5081502469859466 521 P54646,Q15392,Q969T7,P43490,Q8WVC6,Q9Y619,Q9BRR6,O60725,Q9BQE5,Q14534,Q8N4Q0,Q16850,P07099,P38435,P21796,Q8N0U8,P49915,P31939,P21912,Q13510,O75964,O76062,P49902,P16278,Q8TB61,Q14849,Q9H7Z7,A8MXV4,Q06520,Q8NCG7,Q9UBX3,P00374,P50897,P48449,Q9HB40,P24539,P16435,Q14739,Q9H773,P23786,O95470,Q9BXW6,P04062,A1L0T0,Q8WTV0,Q9NRN7,Q53GQ0,O00116,Q9NUJ1,P51648,O75844,Q13126,Q8NCC3,P00403,Q06136,Q9NSD9,P10253,P05067,O15118,O14678,Q15067,Q15800,P42345,P78417,P49748,Q16836,P52789,Q9H2D1,P37268 69 +Regulation of production of small rna involved in gene silencing by rna 0.5282198405969093 1.0000699596656684 0.3172766526652268 1.0 0.5101615767677575 7 O75844 1 +Regulation of cardiac muscle contraction 0.4698908984517301 0.9997890860745258 0.3174125886176215 1.0 0.5101624814975025 15 P0DP25,P16615,P78417 3 +Body fluid secretion 0.4911557746685488 0.9989417754601008 0.3178228975484072 1.0 0.510664508744527 13 Q13505,P00403 2 +Establishment of protein localization to vacuole 0.4326314361410588 0.9979599602754804 0.3182987746671801 1.0 0.5113039313013553 22 Q96RL7,P13473,Q99523,O00203,P46934,Q14108 6 +Phagolysosome assembly 0.4619200466880804 0.9968485881378636 0.3188380097892735 1.0 0.5117942808799445 3 P61106,P51149 2 +Phagosome maturation 0.4619200466880804 0.9968485881378636 0.3188380097892735 1.0 0.5117942808799445 3 P61106,P51149 2 +Response to bacterium 0.3555929380864163 0.9959302701838212 0.319284026484985 1.0 0.5120468951387928 63 Q86UE4,Q8WTV0,Q9BTY2,P30536,Q9P2D1,P32119,P51812,Q9NUQ9,Q9UQB8 9 +Cellular lipid catabolic process 0.3479878056777056 0.995721369207004 0.3193855443162265 1.0 0.5120468951387928 75 Q13510,O95470,Q15067,O14678,P04062,A1L0T0,Q8WTV0,P17900,P49748,A8MXV4,Q8NCG7,Q8NCC3,P50897,Q8NHP8,P23786 15 +Ovulation cycle 0.5191925267560592 0.994469451310356 0.3199943707229893 1.0 0.5127724201915155 9 O95470,P42574 2 +Negative regulation of amine transport 0.4349474912485492 0.9930837249435692 0.3206691545791551 1.0 0.5133522791774618 2 O75915 1 +Negative regulation of anion transport 0.4349474912485492 0.9930837249435692 0.3206691545791551 1.0 0.5133522791774618 2 O75915 1 +Negative regulation of amino acid transport 0.4349474912485492 0.9930837249435692 0.3206691545791551 1.0 0.5133522791774618 2 O75915 1 +Negative regulation of organic acid transport 0.4349474912485492 0.9930837249435692 0.3206691545791551 1.0 0.5133522791774618 2 O75915 1 +Establishment of protein localization to endoplasmic reticulum 0.4315876016000383 0.9906744208087926 0.3218445851936624 1.0 0.5148571838227238 22 P46379,O76094,Q15005,Q9Y5M8,Q7L5D6,O43681,Q15629 7 +Positive regulation of muscle hypertrophy 0.5180902091667445 0.9887400182944952 0.3227903578636315 1.0 0.5158899292803493 9 P09874,P50750,Q9UGN5 3 +Negative regulation of proteolysis 0.3473951440389832 0.9885873920812026 0.3228650573015996 1.0 0.5158899292803493 72 P05067,Q15392,P46379,Q15041,Q92896,Q15418,Q96KC8,P51812,P16435,Q96HY6,P49755 11 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.5220340355472446 0.9881494550589832 0.3230794582155394 1.0 0.5160777519012584 8 O43681,P46379 2 +Regulation of phospholipid metabolic process 0.5135365049097237 0.9874148767234556 0.3234392942560258 1.0 0.5164011311211779 10 Q9UJZ1,Q99623,Q8WTV0 3 +Sensory perception 0.373349371600564 0.9863413925711364 0.3239656141937019 1.0 0.5169898736233152 43 Q9Y5J9,Q9Y5L4,Q15555,Q9P2D1,O76024,Q00535,Q9Y6M9,P50897,Q14108,Q99797,Q9ULX3,Q13432,P42574 13 +N glycan processing 0.4867116081650928 0.986038884651574 0.3241140318958013 1.0 0.5170229852553486 4 Q16706 1 +Release of sequestered calcium ion into cytosol by endoplasmic reticulum 0.5214858752547763 0.9853493928054136 0.3244524787413643 1.0 0.5173037097335502 8 P0DP25,P78417 2 +Response to lipid 0.3122868027138291 0.9851133133496648 0.3245684145498724 1.0 0.5173037097335502 152 P30536,P51812,Q9P0J0,P20020,Q96HY6,P16278,O15228,Q9UBN7,P0DP25,P32119,P16435,P09429,P04062,Q86UE4,Q8WTV0,Q13315,Q13126,Q8TB36,Q9H7B4,O15118,O15173,Q99623 22 +Lymphocyte migration 0.5124824057689236 0.9818408386622578 0.3261782654032448 1.0 0.519132131354861 10 P05067,P04062 2 +Regulation of cytosolic calcium ion concentration 0.4121009490859343 0.98125663223676 0.3264662030854515 1.0 0.5193782246982271 26 P42858,P78417,Q9P2D1,P0DP25,Q07812,P20020,O95202 7 +Prostanoid metabolic process 0.4608661659994018 0.9768685797488272 0.3286342187847477 1.0 0.5220293334880488 16 Q8N4Q0,Q9H7Z7,Q8NCG7 3 +Vacuolar transport 0.3584338446031616 0.9768669075861188 0.3286350467295229 1.0 0.5220293334880488 55 O15118,P13473,P07602,Q9NZJ7,Q14108 5 +Formation of translation preinitiation complex 0.51407229589206 0.9678703406316308 0.3331091285372507 1.0 0.5274763758352894 9 P23588,P55010,Q7Z478 3 +Regulation of natural killer cell mediated immunity 0.5217427925923668 0.9675391764433244 0.3332745665677765 1.0 0.5276110267352834 7 P04439,P11279,P01889 3 +Ventricular cardiac muscle tissue morphogenesis 0.5249213442065814 0.9659415736083136 0.3340734177877942 1.0 0.528238498198435 6 Q99959,Q9P2D1 2 +Muscle organ morphogenesis 0.5249213442065814 0.9659415736083136 0.3340734177877942 1.0 0.528238498198435 6 Q99959,Q9P2D1 2 +Cardiac muscle tissue morphogenesis 0.5249213442065814 0.9659415736083136 0.3340734177877942 1.0 0.528238498198435 6 Q99959,Q9P2D1 2 +Positive regulation of dendrite morphogenesis 0.5133657735380122 0.9642029826455488 0.3349441693125625 1.0 0.529232756809303 9 Q9H2U1,Q9UQB8 2 +Axonemal dynein complex assembly 0.4296966161026895 0.9626562621040108 0.3357200529137012 1.0 0.5295874269773684 2 Q86Y56 1 +Inner dynein arm assembly 0.4296966161026895 0.9626562621040108 0.3357200529137012 1.0 0.5295874269773684 2 Q86Y56 1 +Outer dynein arm assembly 0.4296966161026895 0.9626562621040108 0.3357200529137012 1.0 0.5295874269773684 2 Q86Y56 1 +Electron transport chain 0.3482284224475586 0.9626451481786104 0.3357256321913808 1.0 0.5295874269773684 68 Q7KZN9,P21912,P04062,P03886,P13073,O14949,Q9P0J0,P00403,O43676,Q9UDW1,P47985 11 +Long chain fatty acyl coa metabolic process 0.5130625618668379 0.9626293332617524 0.3357335715065304 1.0 0.5295874269773684 9 Q8WVX9,Q53GQ0 2 +Oocyte differentiation 0.4847057335624484 0.9621591286402476 0.3359696761906978 1.0 0.5297051934558767 13 O14965,Q8N2A8,Q13315,Q9H6S0 4 +Energy derivation by oxidation of organic compounds 0.3202416703577831 0.9610844315589344 0.3365097169061921 1.0 0.530301816123543 125 Q13423,P14406,P14635,O43676,Q16134,P06576,P21912,O75964,Q9BSK2,P13073,P24539,Q96QE5,P47985,P56385,P04062,P03886,P14735,O14949,Q9Y6M9,P00403,Q9UDW1,Q9NZ45,P10253,P42345,P49748,P22695,P51970,Q9UJZ1,Q15070,Q7KZN9 30 +Fatty acid transport 0.4412145187129754 0.9601038210631248 0.3370029655715689 1.0 0.5306967746773783 19 O43772,P23786 2 +Metal ion transport 0.3343075495784947 0.9577882278668922 0.3381695565305929 1.0 0.5316407834100983 107 P42858,Q9NUT2,Q9HD20,P55011,Q9H9B4,P30536,P46934,P17931,P21796,P20020,O95202,Q15043,Q9UM00,Q8NE86,P0DP25,Q96GC9,Q6YHU6,Q99959,Q00535,Q9P2D1,Q4KMQ2,O75844,O76024,P78417,Q15907,Q07812,P50570,Q9UJZ1,O15173,P16615,Q8IYU8 31 +Regulation of fatty acid transport 0.4546250364750684 0.9566026180249492 0.3387678669165366 1.0 0.5321988850146788 3 P14174,P07814 2 +Viral protein processing 0.5156748609945664 0.9556928625411608 0.3392274295581221 1.0 0.5327932964960261 8 Q16706,P48729,Q10472 3 +Wound healing 0.3510106949243329 0.954502758784224 0.3398292135125547 1.0 0.5335707814760215 64 P42345,Q16625,Q8WTV0,P55011,P52429,Q96AY3,P42785,O00203,P38435,P09601,P32119,Q9BWH2,P42574 13 +Response to oxidative stress 0.3360498093654633 0.9498288986284222 0.3421991993888333 1.0 0.5359215146514378 103 P30519,Q15392,P05067,P04062,Q15165,O43169,P09601,P00374,Q8N0U8,Q99720,P16615 11 +Tumor necrosis factor superfamily cytokine production 0.4296828888546171 0.9493833554899882 0.3424256726355699 1.0 0.5360203396552027 21 Q92974,P05067,P09429,P30536 4 +Retinol metabolic process 0.5171433008494926 0.944477224746222 0.3449258349406738 1.0 0.5387772741920261 7 Q6NUM9,O94788,Q9Y394,Q8NBN7 4 +Cellular sodium ion homeostasis 0.4780829899013882 0.9406619195049668 0.3468781396031317 1.0 0.5406684921795132 4 P55011 1 +Negative regulation of jnk cascade 0.519346109927405 0.9384498657439084 0.3480132698206133 1.0 0.5417943242142027 6 P43034 1 +Regulation of lymphocyte differentiation 0.4492363832533199 0.938021077105008 0.3482335785462114 1.0 0.5418739274786043 17 P09429,O15347,P78527,O00203,P32119,O96005,O15360,O14617 8 +Regulation of striated muscle contraction 0.4544715280973878 0.9373246993926015 0.3485915615914488 1.0 0.5420516178111581 16 P0DP25,P16615,P78417 3 +Cellular response to retinoic acid 0.5120029715698577 0.936981634685938 0.3487680049122246 1.0 0.5421666818442046 8 Q13315,Q9P0J0,Q99623 3 +Positive regulation of phosphoprotein phosphatase activity 0.5181663259645045 0.9326394642002672 0.351006150144576 1.0 0.5447734998223056 6 P0DP25,P42345 2 +Mitotic dna replication 0.4984386557685357 0.9306582765596229 0.3520303588301057 1.0 0.546233912188024 11 O75844,Q14691 2 +Phosphatidylinositol phosphate biosynthetic process 0.4787631523188043 0.9283274496819196 0.3532377394220787 1.0 0.5473308255224747 13 Q01968,Q13315,Q8TBX8,Q14156,Q9BTU6,O00443,Q14457 7 +Negative regulation of immune effector process 0.5021929629705003 0.9275194854964616 0.3536568795907167 1.0 0.5475923652369709 10 P04439,P09601,P17931,P01889 4 +Meiotic cell cycle process 0.3636688482836372 0.925502602650072 0.3547045305121226 1.0 0.5488260149069909 46 O95067,Q9BTX1,Q13315,Q9BZD4,P42695,Q14674,P46379,O15360,O14777,O14965,Q96GX5,Q8IXJ6 12 +Neuromuscular process controlling balance 0.4768967983483219 0.917715793659702 0.3587676769441024 1.0 0.5536767394419566 13 P17900,P05067,O14773 3 +Positive regulation of phosphatase activity 0.5117426234665632 0.9174469973440786 0.3589084550227235 1.0 0.553763762487447 7 P0DP25,P42345 2 +Regulation of cell shape 0.3866753742790845 0.915126362529209 0.3601252967412192 1.0 0.5553180539472861 32 O75844,Q9UQB8 2 +Histone arginine methylation 0.4470382258535337 0.9148805603551396 0.3602543364299579 1.0 0.5553180539472861 3 Q86X55,O14744 2 +Peptidyl arginine methylation to asymmetrical dimethyl arginine 0.4470382258535225 0.9148805603550778 0.3602543364299904 1.0 0.5553180539472861 3 O60678,Q86X55 2 +Isoprenoid metabolic process 0.4118903689867011 0.9116353679605136 0.3619606976435296 1.0 0.5571009890837644 24 P37268,P51648,Q9HB40 3 +Protection from non homologous end joining at telomere 0.4725308548902505 0.9115507176951876 0.3620052754424216 1.0 0.5571009890837644 4 Q15554 1 +Response to misfolded protein 0.4988609246623164 0.9099695349856392 0.3628385765262809 1.0 0.5578600607229277 10 P46379,Q9BUN8 2 +Response to retinoic acid 0.4845958748429033 0.9064466190973228 0.3646995070147119 1.0 0.5598030795393075 12 O94788,Q13315,Q9P0J0,Q99623,Q8TB36 5 +Response to insulin 0.3465114658802714 0.9053016174135136 0.36530561978907 1.0 0.5605849565021745 64 Q12965,P43490,Q9Y5X3,Q92572,P20020,Q7L576,Q15043,O60343,P61026,Q9BSK2,P09874,P14735,Q9H1E3,Q9BZF1,Q9UQB8,P42345,P11166,Q16836,P11802,O14654,P78527,Q99523,Q8TBX8 23 +Positive regulation of glucokinase activity 0.4194865810968534 0.9037086213400262 0.366149926405042 1.0 0.561285171715966 2 Q9UNI6 1 +Axon development 0.3397020515666307 0.9036551802750296 0.366178271886018 1.0 0.561285171715966 81 P35613,P30536,Q9BPU6,Q7L576,P42574,O75955,P42892,O15031,Q9UBN7,P00374,P43034,P83731,Q96G23,Q96N67,O00264,Q9UQB8,P05067,P50570,Q9NQC3 19 +Odontoblast differentiation 0.41919486581097 0.902029339474454 0.3670412824487634 1.0 0.5623452942864314 2 P07437 1 +Urogenital system development 0.3584845279031424 0.8985998570985614 0.3688658348649474 1.0 0.5644817183730841 48 O95470,P07602,O75844,P46379,Q9Y5V3 5 +Multicellular organismal movement 0.5002388928904876 0.8962273729804199 0.3701313389902401 1.0 0.5662329997117805 9 P10253,P78417 2 +Regulation of amino acid transport 0.5107401118456726 0.8961309939673513 0.3701828053586617 1.0 0.5662329997117805 6 P55011,Q15042,Q15041 3 +Regulation of protein complex stability 0.4897525321765071 0.8949810557181231 0.3707972149933831 1.0 0.5670406256785319 5 Q969V3,Q9BQ95,Q7Z392 3 +Lymphocyte homeostasis 0.5037058918497256 0.8947981965189595 0.370894974590946 1.0 0.5670579737338741 8 Q07812,P49327,O95067,P42574 4 +Positive regulation of anion transmembrane transport 0.4692373604272287 0.894319909336913 0.3711507505873048 1.0 0.5673168472755402 4 Q15041 1 +Regulation of ribosome biogenesis 0.4177362893815863 0.8936375281286671 0.37151586038602 1.0 0.5677426818474763 2 Q96DE0 1 +Nucleoside phosphate catabolic process 0.4244213522515613 0.8881766558356681 0.3744457337610547 1.0 0.5716875069660403 20 Q9H773,A8MXV4 2 +Regulation of lipid localization 0.412770937962569 0.8876372296517918 0.3747359206695506 1.0 0.5719974671862273 23 Q9Y6B6,P30536,Q8WTV0 3 +Cardiac conduction 0.4206084649239268 0.8872941217489332 0.3749205695294382 1.0 0.5720780383546444 21 P0DP25,O75844,P16615,P20020 4 +Phosphatidylinositol biosynthetic process 0.3899478195234015 0.8872151700179596 0.3749630665899612 1.0 0.5720780383546444 28 Q92643,Q01968,P52429,Q9NTJ5,Q13315,Q8TBX8,O43292,Q14457,Q9H490,Q9BTU6,Q14156,Q96N66,O00443 13 +Regulation of synaptic vesicle recycling 0.5054759669194399 0.8861596565820704 0.3755314998726713 1.0 0.5726003766271772 7 P0DP25,Q7L576 2 +Regulation of response to interferon gamma 0.4417858185001622 0.8860933831714645 0.3755672083211476 1.0 0.5726003766271772 3 P08238,Q16543 2 +Receptor recycling 0.5053323140469447 0.8854435202218194 0.3759174688558788 1.0 0.5727962900684389 7 Q15907 1 +Atp synthesis coupled proton transport 0.4899121074994171 0.8849622794754414 0.3761769759955544 1.0 0.5727962900684389 11 P24539,O75964,Q9UJZ1,P56385 4 +Regulation of synaptic vesicle exocytosis 0.4898940030706575 0.884865428074479 0.3762292160871328 1.0 0.5727962900684389 11 P0DP25,P16615,Q00535 3 +Cellular response to radiation 0.34973235438716 0.8839774031416113 0.3767084111961341 1.0 0.5728229568560669 54 Q13535,Q96MG7,P09874,Q13315,P50570,P46934,O75844,Q9H2U1,Q9H1E3,P27544,Q07812,P28340,P29692 13 +Interleukin 1 production 0.4805096510474352 0.88393402058084 0.3767318308910603 1.0 0.5728229568560669 12 P05067,P49755,Q99584 3 +Pore complex assembly 0.4604519217484421 0.8805554043167974 0.3785585050464495 1.0 0.5742926499015414 14 Q9BTX1 1 +Regulation of maintenance of sister chromatid cohesion 0.4154025670945263 0.8802271671730616 0.3787362590487126 1.0 0.5742926499015414 2 O75367 1 +Positive regulation of maintenance of sister chromatid cohesion 0.4154025670945263 0.8802271671730616 0.3787362590487126 1.0 0.5742926499015414 2 O75367 1 +Osteoclast development 0.4665063276588679 0.8800553417256654 0.3788293301242156 1.0 0.5742926499015414 4 Q15904 1 +Negative regulation of peptidase activity 0.3609530638793273 0.8799892844172619 0.3788651145113948 1.0 0.5742926499015414 44 P05067,Q15392,P51812,P16435,Q15418 5 +Myoblast migration 0.4403268164575609 0.878112986589197 0.3798824060685857 1.0 0.5754762789138133 3 Q7Z628,Q13464 2 +Endocrine system development 0.4697288546562692 0.8770331147136688 0.3804686518277398 1.0 0.5759250964921865 13 P30536 1 +Central nervous system neuron development 0.4696914512963117 0.8768211598946002 0.3805837840445347 1.0 0.5759665108164753 13 Q9UPW5,Q00535,O14949,P43034,O75592 5 +Production of molecular mediator of immune response 0.3663877648499737 0.875377919444527 0.381368309957204 1.0 0.5767101768512122 39 P09601,Q13426 2 +Positive regulation of cation channel activity 0.4920665321175497 0.8742597453297781 0.3819768161074912 1.0 0.5770108033530431 10 P42858,P78417 2 +Cellular carbohydrate catabolic process 0.4278815800748393 0.8724312028251117 0.3829731843779704 1.0 0.5782489728228813 19 Q14108 1 +Leukocyte homeostasis 0.4874613427349998 0.8718591559841301 0.383285217990654 1.0 0.5785869796307044 11 Q07812,P49327,P09429,O95067 4 +Response to oxygen containing compound 0.2922931853191873 0.8684220029518586 0.3851633538779535 1.0 0.5809746796297661 305 P54646,P35613,P43490,P30536,Q9Y5X3,Q9H4A6,P09601,P51812,Q9H2U1,Q9P0J0,P20020,Q99720,Q9BRK5,Q15043,Q9BSK2,P16278,Q92974,O15228,Q9UBN7,P0DP25,P32119,P00374,P49770,P16435,P09429,P04062,Q86UE4,Q8WTV0,P14735,Q13315,Q8N5M9,Q13126,Q9H1E3,Q9UQB8,Q8TB36,Q9H7B4,P05067,P42345,Q15388,Q16836,Q8TBX8,Q15907,P27544,Q99623,Q9UNS1 45 +Cellular response to inorganic substance 0.358717227743463 0.8683164926576883 0.3852210958654545 1.0 0.5809746796297661 45 P54646,P05067,P30536,P09601,Q9UNS1 5 +Response to ionizing radiation 0.3575218852789016 0.8669634140425804 0.3859620559930596 1.0 0.5819584125520353 46 Q9NXR7,Q6PJG6,Q92547,Q13535,P09874,Q13315,P78527,P50570,O75844,Q07812,Q9H1E3,Q13426,P29692,P42574 14 +Cytosolic transport 0.3367747180708837 0.8666010901039242 0.3861606160443138 1.0 0.582124043758968 71 O95249,O94832,Q96RL7,Q4KMP7,Q9BVK6,O75165,O15260,Q9Y5X3,Q13190,Q9Y5X2,P53367,A4D1P6,Q8NBN3,O75503,P11279 15 +Establishment of golgi localization 0.4379924131893883 0.8653600030683902 0.3868412266834264 1.0 0.5827484227494593 3 P60953,Q9Y678 2 +Apoptotic mitochondrial changes 0.3786571004507996 0.865053802601442 0.3870092591412741 1.0 0.5828677435127475 33 O14737,P52789,P45880,Q96A26,P12235 5 +Programmed necrotic cell death 0.447460468342981 0.8640314552159051 0.3875706112078485 1.0 0.5833302875000647 15 Q13510,P49327,Q92974,Q07812,P12235 5 +N terminal peptidyl methionine acetylation 0.4374088123723466 0.8621748762704398 0.3885912927583388 1.0 0.5843116551512877 3 Q5VZE5,Q9BXJ9 2 +Smad protein signal transduction 0.4972263682138306 0.8619661216532106 0.3887061609551341 1.0 0.5843504761025407 8 P09874,Q9UIQ6 2 +Sulfur compound biosynthetic process 0.3579713969686219 0.8612792712688767 0.389084249454716 1.0 0.5847848934772896 45 Q8TB61,Q96L58,Q53GQ0,Q13126,P50897 5 +Positive regulation of membrane permeability 0.4569368648226393 0.8600265076297527 0.3897744306972712 1.0 0.5855539867755252 14 Q07812,P45880 2 +Vesicle targeting to from or within golgi 0.4466917012109588 0.8593994529517925 0.3901201714350311 1.0 0.5858753273659816 15 Q9Y6B6,Q15363,P49755,Q9NR31 4 +Membrane depolarization during cardiac muscle cell action potential 0.4368252115553082 0.8589910325462279 0.3903454634629795 1.0 0.5858753273659816 3 Q12955,Q9HD47 2 +Regulation of membrane depolarization during cardiac muscle cell action potential 0.4368252115553082 0.8589910325462279 0.3903454634629795 1.0 0.5858753273659816 3 Q12955,Q9HD47 2 +Regulation of membrane depolarization during action potential 0.4368252115553082 0.8589910325462279 0.3903454634629795 1.0 0.5858753273659816 3 Q12955,Q9HD47 2 +L alpha amino acid transmembrane transport 0.4850003030523623 0.858716956818475 0.3904966928799198 1.0 0.5859157341714739 11 Q9Y619,Q15041,P30825 3 +Eye morphogenesis 0.4565673645544502 0.8578705922496042 0.3909639243261229 1.0 0.5862672009661835 14 Q07812,P54802,Q16706,Q15555 4 +Positive regulation of ossification 0.4620466898166981 0.8568120692672453 0.3915487544150737 1.0 0.5868759539679567 4 P20020 1 +Positive regulation of cilium assembly 0.502625019407608 0.8563846420857152 0.391785056784685 1.0 0.5870960362231338 6 P42858 1 +Positive regulation of dendritic spine development 0.4747097667665413 0.8520534856928723 0.3941844068707283 1.0 0.5898832560742803 12 P43034,Q14444,Q9H2U1,Q9UQB8 4 +Regulation of cell death 0.2775440055198624 0.8507530825291899 0.3949065291404163 1.0 0.5905598551092552 358 P54646,Q15392,Q9NS69,P42858,Q9P032,P30536,P45880,Q86XL3,Q9H4A6,P09601,P51812,P21796,Q9P0J0,P61289,Q99720,Q96HY6,Q9Y5V3,Q13510,Q15041,Q9Y6C9,Q92974,Q9UGN5,Q9UBN7,P32119,P50897,P16435,P12235,P09429,P04062,Q86UE4,O15269,Q9UMX5,Q9BXK5,O14737,Q9NQX7,Q13315,Q7Z3C6,O76024,P00403,Q96A26,Q01105,Q15418,P18085,O14965,O95881,P49327,O15118,Q9NVI7,P78527,Q07812,P50570,Q9NZJ7,Q99623,P46379,Q9NQC3 55 +Regulation of response to wounding 0.411458919737655 0.8505187843253571 0.395036721439407 1.0 0.5906199512611959 22 P32119,P42345,Q16625,Q96G23 4 +Acid secretion 0.4350744091041909 0.8494473795515718 0.3956323986654835 1.0 0.5913758086658093 3 P21359,O75146 2 +Regulation of ossification 0.4902100917018003 0.8445577096128304 0.3983578294851955 1.0 0.5936915914335346 9 O75844 1 +Sprouting angiogenesis 0.4342390247892853 0.8436939258719469 0.3988404626528796 1.0 0.5941410024808618 17 P09601 1 +Gliogenesis 0.3451207794715745 0.8431719727778075 0.3991322708712101 1.0 0.5944407538485886 56 P05067,Q15382,P42345,P04062,P30536,P06493,O94901,Q96G23,P49770,P43034,Q9NQC3,Q96N66,Q8IXJ6 13 +Sodium ion homeostasis 0.4997077990646249 0.8421403652794158 0.3997093892843772 1.0 0.5948952171658163 6 Q9Y5X3 1 +Glycerol 3 phosphate metabolic process 0.4086931155192513 0.8417966224785787 0.3999018028184791 1.0 0.595046628139424 2 Q8N335 1 +Cellular response to virus 0.4021573490048586 0.8414629926004686 0.4000886087929789 1.0 0.59518962840615 24 Q07812,O43657,Q9NUD5 3 +Midbrain development 0.4137994616346586 0.8408394788727825 0.4004378670793151 1.0 0.5953043234649901 21 Q5T9L3,P14854,P0DP25,O14949,P24539,Q8IXJ6 6 +Chemical synaptic transmission postsynaptic 0.4630607397605201 0.8393095239745801 0.4012956401433196 1.0 0.5960393822137763 13 Q9UQB8 1 +Regulation of postsynaptic membrane potential 0.4630607397605201 0.8393095239745801 0.4012956401433196 1.0 0.5960393822137763 13 Q9UQB8 1 +Pyridine containing compound metabolic process 0.4885546011466894 0.8360554509587882 0.4031237087222776 1.0 0.5984836598723046 9 Q13126 1 +Import across plasma membrane 0.4379043358704341 0.8352928436894185 0.4035528457069375 1.0 0.5988966157461191 16 P11166,Q15041,P55011,P05023,Q9BXP2,O75915,P30825,Q15043 8 +Regulation of generation of precursor metabolites and energy 0.3688016323549626 0.8342843209031955 0.4041207850355848 1.0 0.5992860093567248 36 P54646,P05067,Q9BSK2,P14406,P14735,Q99623,Q9NZ45 7 +Regulation of hydrolase activity 0.2902142878638902 0.8334169419434275 0.4046096230493892 1.0 0.5996044142841219 187 Q15392,P42858,Q01968,P17931,P51812,P78318,Q9P0J0,Q14108,P61289,Q96HY6,Q15043,O60343,Q15041,O15031,Q15555,P0DP25,P49354,P50897,P16435,P43034,P49755,Q96N67,P09429,Q4KMP7,Q9BXK5,O14737,P07602,Q92530,Q96A26,Q15554,Q15418,P18085,O75190,P05067,P42345,P49327,Q99523,Q15363,Q07812,Q9NZJ7,Q99623,Q66K14,Q96GX5 43 +Negative regulation of telomere capping 0.4773103514173284 0.8322123179843303 0.4052891121920026 1.0 0.6001837891546495 5 Q15554,Q13315 2 +Fatty acyl coa biosynthetic process 0.4840364791769027 0.832211818615256 0.4052893940111755 1.0 0.6001837891546495 10 P50897 1 +Multicellular organism growth 0.3782455973590364 0.832075311821582 0.4053664360764106 1.0 0.6001837891546495 31 O95470,P05067,Q13315,Q9P2D1,Q15363,O75844 6 +Protein targeting to peroxisome 0.4571104014896487 0.8311640574468838 0.405880956407564 1.0 0.6006745232175091 4 O75381 1 +Amino acid import across plasma membrane 0.4970781338823036 0.8293220637924265 0.4069221891354377 1.0 0.6018082950432145 6 P30825 1 +Positive regulation of transcription elongation from rna polymerase ii promoter 0.483380953172416 0.8287877694027634 0.4072245102043785 1.0 0.6021197016586598 10 P35269 1 +Regulation of t cell differentiation 0.4609846431849642 0.8275924056747428 0.4079013705795125 1.0 0.6025773961600092 13 P09429,O00203,P32119,O96005,O15360 5 +Response to reactive oxygen species 0.3577722176243865 0.8272571394805351 0.4080913313528269 1.0 0.6027223309334347 41 Q99720,P09601 2 +Cerebral cortex cell migration 0.4790029667991313 0.8267637983584577 0.4083709526988368 1.0 0.6029995930715047 11 P43034,Q96N66,O94901,Q9NQC3 4 +Regulation of entry of bacterium into host cell 0.455815866972585 0.8244528671740278 0.4096822862145721 1.0 0.6045278079919096 4 Q9BTY2,Q96KP1 2 +Response to vitamin 0.4404803585955421 0.8220448252902999 0.4110513856248934 1.0 0.6060166816623626 15 P04818,P30536,Q96C86,P20020,Q8TB36 5 +Cellular response to heat 0.373413455377438 0.8217721854338406 0.4112065668406477 1.0 0.6060955731375405 33 P42345,Q13535,Q13315,P09601,Q9H2U1 5 +Embryonic digit morphogenesis 0.4891214371234818 0.8210630145507042 0.4116103757305245 1.0 0.6065545217928816 8 P42892 1 +Cellular pigmentation 0.468902977656788 0.820234621978309 0.4120823684496262 1.0 0.606750328068808 12 Q15907,O14617,O00203 3 +Positive regulation of multicellular organismal process 0.2932225492423106 0.8184951742730023 0.4130744964373676 1.0 0.6077566918434991 213 Q13546,P50750,Q96FZ2,P30536,Q9Y5X3,Q13641,P09601,P17931,Q9H2U1,P20020,Q7L576,Q68CQ4,Q9Y5V3,O75955,Q14444,Q15382,Q16706,Q9NUD5,Q92974,P09874,O15031,Q9UGN5,P32119,Q9NUQ9,P16435,P43034,P49755,Q99584,P23786,P09429,P04062,Q86UE4,P06493,Q9P2D1,P55209,Q9UQB8,P05067,P42345,Q16836,P78417,P52789,P78527,O00203,Q9UJZ1,O00767,P16615,Q9NZ08,Q9NQC3 48 +Regulation of leukocyte differentiation 0.3795680742948188 0.8174076276002028 0.4136955181612736 1.0 0.6083975773586457 29 Q13546,P09429,P42345,P01889,P78527,O00203,P32119,O96005,O15360 9 +Negative regulation of ion transport 0.4136575072926159 0.8160680919552997 0.4144611922104411 1.0 0.6091140746438778 20 P21796,P78417 2 +Sodium ion transport 0.3942655091860061 0.8148367952370345 0.4151657359517409 1.0 0.6098221993586198 25 Q8N335,P55011,Q9HD47,Q99959,P23634,O43865,P50570,P46934,Q4KMQ2,P05023,Q16795,Q9Y6M7 12 +Positive regulation of translation 0.3401072365718111 0.8088404442881757 0.418606929157407 1.0 0.6134208729635786 60 Q9NWS8,Q7Z478,O15031,P98179,Q9Y2R0,Q9H2U1,Q567V2 7 +Regulation of integrin activation 0.4028588098016346 0.808548071702359 0.4187751444079262 1.0 0.6135303633857584 2 O94887 1 +Cellular response to starvation 0.3716418038017794 0.8071685226854532 0.4195693981868851 1.0 0.6144196364432805 33 P54646,P49327,P21964,P42345,P04062,P13473,P11166,Q9Y4P3,P54619 9 +Peptidyl threonine modification 0.3585018364953321 0.8050941985671269 0.4207653233414805 1.0 0.615822605610647 39 P05067,P42345,Q10472,P06493,P78527,P0DP25,Q8N4A0,Q8IXJ6 8 +Interleukin 6 production 0.4467583315505846 0.8008026030565807 0.4232459318221957 1.0 0.6184234701886547 14 Q92974,P05067,P09429,P04062 4 +Small molecule biosynthetic process 0.3020323532008452 0.7979072338653797 0.4249243251922483 1.0 0.6204613755922416 149 P54646,Q15392,Q16850,Q13510,O76062,Q14849,Q9H7Z7,Q8NCG7,Q9UBX3,P00374,P48449,P16435,Q14739,Q9BXW6,P04062,A1L0T0,Q53GQ0,Q13126,Q15800,P49748,P37268 21 +Negative regulation of response to wounding 0.4734182917818199 0.7971140465171587 0.4253847992289432 1.0 0.6206995693507783 11 Q96G23 1 +Phosphatidylinositol metabolic process 0.3754783769712014 0.796991555945011 0.4254559354132095 1.0 0.6206995693507783 30 Q92643,Q01968,P52429,Q9NTJ5,Q13315,Q8TBX8,O43292,Q6UWP7,Q14457,Q9H490,Q9BTU6,Q14156,Q96N66,O00443 14 +Positive regulation of transporter activity 0.3958239598861429 0.7959620516047518 0.4260540926900269 1.0 0.6213181521680929 24 P42858,P78417,P0DP25,P50570,Q96GC9,Q03164,P08183 7 +Positive regulation of cellular response to insulin stimulus 0.4841181338317925 0.7959188639218365 0.4260791960921088 1.0 0.6213181521680929 8 Q9BZF1,Q9H1E3,Q9Y5X3 3 +Cardiac muscle contraction 0.3993910600915957 0.7931618200581286 0.4276835488271753 1.0 0.6224311027289909 23 P78417,Q99959,P0DP25,P16615,P10253 5 +Cellular response to light stimulus 0.3717224935904259 0.7931402660336884 0.4276961051821122 1.0 0.6224311027289909 32 Q13535,Q96MG7,P09874,Q07812,P46934,P27544,Q9H2U1,P28340 8 +Regulation of glycoprotein metabolic process 0.4634422552544434 0.7904172009335323 0.4292841599830013 1.0 0.6240834275867033 12 Q9Y287 1 +Cartilage development 0.4351635502463776 0.7901818173667404 0.4294215932367651 1.0 0.6240834275867033 15 Q92896,O75844,P16435,Q96HY6,Q15043 5 +Forebrain cell migration 0.463196738225844 0.7890792157776525 0.4300657088278798 1.0 0.6243564560461389 12 P43034,Q96N66,O94901,Q9NQC3 4 +Regulation of vesicle mediated transport 0.3079641540760544 0.788833202323984 0.4302095009874507 1.0 0.6244120732305463 128 O75165,P09601,P17931,P11279,O75955,P57105,Q9Y6B6,P0DP25,P50897,Q9H223,P20337,P61020,P09429,Q8WTV0,Q00535,P53367,P05067,Q9P2W9,Q12907,Q15907,P50570,Q9NR31,P16615,Q13432 24 +Positive regulation of calcium ion transmembrane transport 0.4444662291116635 0.7875185950281961 0.4309783474277768 1.0 0.6252663974842078 14 P42858,P78417,Q07812,P0DP25,Q96GC9 5 +Vesicle targeting rough er to cis golgi 0.4715190013657089 0.7870560148554127 0.4312490763091019 1.0 0.6253826383956523 11 Q9Y6B6,Q15363,Q9NR31 3 +Positive regulation of catabolic process 0.2928494461898107 0.7856702760891776 0.4320606813347276 1.0 0.6261859863237902 165 P54646,P42858,Q969T7,P09601,Q9H2U1,P21796,Q9P0J0,Q9BQS8,Q96HY6,Q13190,Q8NCG7,Q9HCE1,P12235,P09429,P04062,Q86UE4,O15269,P14735,Q13315,P48729,Q6ZXV5,P05067,Q8TBX8,Q07812,P27544,P46379 26 +Response to hydroxyurea 0.484820202544513 0.7837997315143395 0.4331576314244667 1.0 0.6273185560378174 7 Q9UNS1 1 +Response to hormone 0.2887180505413176 0.7834836424504332 0.4333431556595086 1.0 0.6273485151665938 194 P54646,P35613,Q15392,P43490,P30536,Q9Y5X3,P09601,P20020,Q96HY6,Q15043,Q9BSK2,P16278,Q9UBN7,P42785,P0DP25,P49770,P16435,P04062,P14735,Q9H1E3,Q9UQB8,Q9H7B4,O15118,P42345,Q16836,Q8TBX8,O15173,Q99623 28 +Positive regulation of t cell proliferation 0.4812915626027741 0.7817538603675912 0.4343592416490147 1.0 0.6280884406568609 8 P04439,P09429,P30825 3 +Glycerophospholipid biosynthetic process 0.34851811957334 0.7813283593727491 0.4346093946356588 1.0 0.6283117090987427 46 Q6IAN0,Q01968,Q9NPH0,P52429,O15228,O43292,Q9H490,P48651,Q8NF37,Q96N66,O00443,Q92643,Q13315,Q8WVX9,Q14156,Q9BTU6,Q9NTJ5,Q9NUQ2,Q8TBX8,Q6UWP7,Q14457 21 +Anterior posterior pattern specification 0.4082064249714445 0.7797130639612648 0.4355597875094426 1.0 0.6288544170818399 20 Q5T9L3,Q8N2A8,Q13315,Q15363,O14965 5 +Peripheral nervous system development 0.4516041375106943 0.7748448929227127 0.4384313182914687 1.0 0.6323046836546413 13 Q9NR77,P06493,Q8IXJ6,P51648 4 +Histone h3 k4 trimethylation 0.4691011708800432 0.7742721322170243 0.438769879943933 1.0 0.6326539117099732 11 P10412,P16402,Q03164 3 +Negative regulation of neuron death 0.350439858973861 0.773966967681909 0.4389503255169082 1.0 0.632775051854559 43 P04062,Q9UMX5,Q9UGN5,O76024,P09601,Q07812,P50897 7 +Regulation of ion transmembrane transport 0.333722973020754 0.7729293145262179 0.4395642147298968 1.0 0.633129742761134 65 P05067,Q13546,P42858,Q15041,P78417,Q00535,P0DP25,P46934,Q9P2D1,O75844,P21796,Q96GC9,P50570,P08183,Q07812,Q6YHU6,Q99623 17 +Coenzyme a metabolic process 0.4726211384025862 0.7727983040500939 0.4396417572710318 1.0 0.633129742761134 10 A8MXV4 1 +Negative regulation of neuron projection development 0.4037185931164869 0.7723650151032384 0.4398982684517092 1.0 0.6333068094734787 21 Q9NQX7,Q96G23,Q9NQC3 3 +Positive regulation of anion transport 0.4791378816742378 0.770981656316117 0.4407178045704185 1.0 0.6343474958523988 8 P55011,Q15041,P08183 3 +Clathrin dependent endocytosis 0.4068255893573995 0.7705248415995843 0.4409886250685333 1.0 0.6344366549909718 20 Q5VW38 1 +Inorganic ion import across plasma membrane 0.4820783748898997 0.7703220198225462 0.4411088975879562 1.0 0.6344366549909718 7 Q9BXP2,P55011,P05023,Q15043 4 +Neurotransmitter secretion 0.4173776975819308 0.7696486113773353 0.4415083609271781 1.0 0.6347891902725993 18 P16615,Q13277,P50897 3 +Positive regulation of pathway restricted smad protein phosphorylation 0.4201925882696367 0.7688708240662137 0.4419699991367758 1.0 0.6353137205554267 3 O00560,P33981 2 +Negative regulation of cell activation 0.395893529930913 0.7685797146789513 0.4421428516098347 1.0 0.6354229943634988 23 P09429,Q13315,P09601,P17931,P32119,P42574 6 +Muscle adaptation 0.4119557395197821 0.7684019978654243 0.4422483938123636 1.0 0.6354355069403831 19 P09601,P16615,Q9UGN5 3 +Superoxide metabolic process 0.4814514961853135 0.7672447411669666 0.4429360161980304 1.0 0.6361449197398722 7 P00374 1 +Regulation of leukocyte migration 0.3834637870101851 0.766833092865931 0.4431807579646465 1.0 0.6362523444516088 26 P05067,P09429,Q8NE86,P09601,P17931 5 +Roof of mouth development 0.4840294213224115 0.7660649911161563 0.4436376324852857 1.0 0.6365952644584397 6 O95470 1 +Protein k29 linked ubiquitination 0.4440937516251461 0.7640036936313035 0.4448650414723434 1.0 0.6376593276849098 4 Q16763,Q96J02 2 +Microtubule anchoring 0.4663876214992747 0.7599529738717747 0.4472826950016655 1.0 0.6399334392387925 11 Q15154,O95684,Q9Y496,O75381,Q8TD16,Q9P287 6 +Anatomical structure maturation 0.3599810145230773 0.7588709429084162 0.4479297623880967 1.0 0.6403736603029826 36 O75503,P05067,Q8N2A8,P04062 4 +Heat acclimation 0.3935239206534509 0.7557372236223198 0.4498067615385901 1.0 0.642357338240746 2 Q16576 1 +Cellular response to x ray 0.4783954027397668 0.7522660237535673 0.4518910958395585 1.0 0.6446391604578631 7 Q9H1E3,Q13315 2 +Protein localization to extracellular region 0.3302687580861451 0.7512266759981144 0.4525162485631777 1.0 0.6452269734257058 67 Q5T9L3,P53985,Q16836,Q8NE86,P55011,Q9H4A6,Q16850,Q96KC8,P53367,Q8N5M9,Q15907,P43034,P49755,Q96PC5 14 +Replicative senescence 0.4607044005708574 0.7492969607512625 0.4536782392376883 1.0 0.6463478897570983 5 Q13535 1 +Positive regulation of atp metabolic process 0.4771806693242648 0.7463233652194076 0.4554721002776527 1.0 0.6479632960444536 7 P05067,P00403 2 +Positive regulation of jnk cascade 0.4706763405477766 0.744847785803855 0.456363743161158 1.0 0.6486157423919252 9 P05067,P09429 2 +Protein containing complex localization 0.3402261903177513 0.7442407529947308 0.4567308373266405 1.0 0.6488564092958249 50 P57105,Q15154,O15400,Q13277,A0AVF1,Q13535,Q96D46,Q9BTX1,Q13315,O43805,Q15554,O60645,O14617,P62841 14 +Generation of precursor metabolites and energy 0.2850018825472263 0.742082863719002 0.4580371316665264 1.0 0.6498680341612424 186 P54646,Q13423,P14406,Q9BRR6,Q9P0J0,O43676,P21912,O75964,Q9BSK2,P13073,P16435,P24539,P12235,P47985,P04062,P03886,P14735,O14949,P00403,Q9UDW1,Q9NZ45,P10253,P05067,Q15067,P49748,P22695,P52789,Q15070,Q7KZN9 29 +L glutamate import across plasma membrane 0.4149096568418436 0.7405402640873394 0.4589722391983994 1.0 0.6507726520354142 3 Q15041 1 +Regulation of amino acid transmembrane transport 0.4149096568418436 0.7405402640873394 0.4589722391983994 1.0 0.6507726520354142 3 Q15041 1 +Regulation of l glutamate import across plasma membrane 0.4149096568418436 0.7405402640873394 0.4589722391983994 1.0 0.6507726520354142 3 Q15041 1 +Anaphase promoting complex dependent catabolic process 0.4624110462754975 0.7390265083326111 0.4598909009299161 1.0 0.6515409750290139 11 Q9H1A4,Q9UJX4,Q9UJX3,Q9UJX2,Q16763,P53350,Q13042,P30260 8 +Cellular response to uv 0.3681048982953429 0.7385183077141697 0.4601995461909434 1.0 0.6516087669902787 30 Q13535,Q96MG7,Q07812,P46934,P27544,Q9H2U1,P28340 7 +Positive regulation of developmental process 0.2873587806189776 0.7381142144741322 0.4604450466548977 1.0 0.6517343391176529 201 Q13546,Q8N2A8,Q96FZ2,P30536,Q13641,P09601,P17931,P51812,Q9H2U1,P20020,Q7L576,Q68CQ4,Q9Y5V3,O75955,Q14444,Q15382,Q16706,Q9Y6C9,Q8NE86,P09874,Q92974,O15031,Q9UGN5,P16435,P43034,Q8IXJ6,Q8WUJ1,P09429,Q86UE4,P06493,Q9P2D1,P55209,Q15418,O14965,Q9UQB8,P42345,P52789,P78527,O00203,Q07812,P50570,Q9NZ08,Q9NQC3 43 +Regulation of lipid catabolic process 0.4723058210825914 0.7369371248758968 0.4611605861472392 1.0 0.6520439056880379 8 Q8WTV0 1 +Golgi localization 0.4381202568593171 0.7334514485507996 0.4632831297624562 1.0 0.6544809251886411 4 P48444,P60953,Q9Y678 3 +Cellular response to peptide 0.3254858425372406 0.7324948543272151 0.463866582296873 1.0 0.6550231360086252 76 Q12965,P43490,P46108,Q9Y5X3,Q92572,P20020,Q7L576,Q15043,O60343,P61026,Q9BSK2,Q92974,P09874,P16435,P14735,O43865,Q00535,Q9H1E3,Q9BZF1,Q9UQB8,P05067,O14654,P11802,P78527,Q8TBX8,Q9UNS1 26 +Regulation of jnk cascade 0.4162619713101286 0.7316553533883121 0.4643789534392077 1.0 0.6556055706686922 17 P43034,P05067,Q13546,P09429 4 +Regulation of neurotransmitter transport 0.4206136485039705 0.7298365780016208 0.46549008304429 1.0 0.6566091842082183 16 O75955,Q00535,P0DP25,P16615,P20337 5 +Meiotic chromosome segregation 0.3902434953750812 0.7289983579814451 0.4660026669070503 1.0 0.6570497422097258 23 Q9BTX1,Q13315,Q14674,P46379,Q9BZD4 5 +Regulation of ryanodine sensitive calcium release channel activity 0.4728674064348462 0.7252757864628029 0.4682828572249953 1.0 0.6594655484103082 7 P78417 1 +Positive regulation of cell growth 0.343919178186128 0.7210088325500379 0.4709040804506523 1.0 0.6614025205302185 44 Q9BSK2,O95684,Q9UGN5,P51812,Q15418 5 +Regulation of cartilage development 0.474439392580173 0.720009416717699 0.4715191976813311 1.0 0.661983092679695 6 P16435 1 +Regulation of chondrocyte differentiation 0.474439392580173 0.720009416717699 0.4715191976813311 1.0 0.661983092679695 6 P16435 1 +Dendritic spine morphogenesis 0.4093617573750574 0.718854649282016 0.4722304815791416 1.0 0.6626981223529357 18 Q14444,Q9UBN7,Q9H2U1,P43034,Q9UQB8 5 +Cardiac ventricle morphogenesis 0.4711023704446503 0.7166880222310169 0.473566618173568 1.0 0.6641982964855248 7 Q99959,Q9P2D1 2 +Negative regulation of circadian rhythm 0.3865227537923056 0.7164939343415991 0.4736864115536674 1.0 0.6641982964855248 2 P23246 1 +Response to estrogen 0.4319683648389671 0.7155055133842657 0.4742967352721328 1.0 0.6646028564714361 14 P09601 1 +Exocytosis 0.323731271280799 0.7149227665642227 0.474656768320596 1.0 0.6646815436875269 72 Q13277,P0DP25,P09601,Q8N5M9,Q15907,Q96KP1,P16615,P49755,Q99584,Q9BRK5 10 +Regulation of body fluid levels 0.3372070318084718 0.7145266623394231 0.474901575360009 1.0 0.6648824701327883 50 P04062,P52429,Q13505,P52789,O00203,O76024,P38435,P32119,Q4KMQ2,P00403,Q9BWH2 11 +Regulation of lipid transport 0.413363378848689 0.7137378381025227 0.475389304264719 1.0 0.665413228415681 17 Q9Y6B6,P30536 2 +Transcytosis 0.4675617495752479 0.7134216356067766 0.4755848889468979 1.0 0.665413228415681 8 Q15907 1 +Positive regulation of neuron apoptotic process 0.4403472499094293 0.7120505785418498 0.4764334563599535 1.0 0.6659971122026742 13 Q13315,Q00535,Q07812,Q07820,P42574 5 +Cellular response to exogenous dsrna 0.4531375915646529 0.7119275064237255 0.4765096680572318 1.0 0.6659971122026742 5 Q9NUD5 1 +Purine containing compound biosynthetic process 0.3236174991318996 0.711034980661084 0.477062559253258 1.0 0.6664859514200296 75 O75964,Q8WVC6,Q8TB61,Q53GQ0,Q13126,P50897,P00403,P24539,P31939 9 +Phosphatidylglycerol metabolic process 0.4601151794388528 0.7083208742437103 0.4787460170420514 1.0 0.6680952602129184 10 Q9UJZ1,Q8NCC3,Q99623 3 +Regulation of calcium ion transmembrane transporter activity 0.407536503119356 0.7073387893818959 0.4793559657167858 1.0 0.6680952602129184 18 P42858,P78417,P0DP25,Q96GC9,Q6YHU6 5 +Carbohydrate derivative metabolic process 0.2886289243898071 0.7072959122443528 0.4793826053076981 1.0 0.6680952602129184 272 P54646,Q8WVC6,Q8NBX0,Q9BRR6,O60725,Q9H4A6,P49915,Q8N4A0,P31939,O75964,P16278,Q9NPH0,Q8TB61,Q9Y287,A8MXV4,Q06520,Q7LGA3,O43292,P50897,Q86YN1,P24539,Q9H773,P04062,Q53GQ0,Q9NQX7,Q9NUJ1,Q13126,P00403,P05067,O15118,O60502,O60512,P17900,Q96L58,P52789,O43505,P54802 37 +Protein processing 0.3396223593275677 0.7061087892163302 0.480120486294517 1.0 0.668764727460119 47 P42892,Q15392,P67812,P09874,Q92896,Q8TCT9,O75844,Q9H9S5,O75503,Q99797,Q9UJZ1,P42574 12 +T cell activation involved in immune response 0.4688246409580642 0.7056283863136765 0.4804192666012647 1.0 0.6690388852796051 7 P17931,P42345,P09429 3 +Bone morphogenesis 0.462854517379121 0.705367938222602 0.4805812912363798 1.0 0.6690885331221189 9 O75844,Q92896,P16435 3 +Morphogenesis of a branching structure 0.4021989190208477 0.7052432895545963 0.4806588456473131 1.0 0.6690885331221189 19 Q15363,Q9UNS1,Q9Y5V3,Q9NQC3 4 +Vascular process in circulatory system 0.3574171093762894 0.7047392037202214 0.4809725493357522 1.0 0.6693832171243278 34 P08183,P42892,Q16625,P55011,P20020,Q9HB40,P30825 7 +Positive regulation of fibroblast proliferation 0.4684263773120348 0.703697281640592 0.4816213135846015 1.0 0.6698304227686953 7 P14635,P11802 2 +Pancreatic juice secretion 0.3841890315052498 0.7034912908278318 0.4817496323799488 1.0 0.6698304227686953 2 P53621 1 +Secretion by tissue 0.3841890315052498 0.7034912908278318 0.4817496323799488 1.0 0.6698304227686953 2 P53621 1 +Sulfur compound metabolic process 0.315215141048061 0.7034035957771553 0.4818042663011646 1.0 0.6698304227686953 107 P16278,P78417,Q8TB61,Q53GQ0,Q96L58,Q9H7Z7,O60725,A8MXV4,Q06520,Q9UBX3,Q13126,P50897,O15217 13 +Receptor mediated endocytosis 0.33004642768631 0.7019255742983668 0.4827255789777516 1.0 0.6708230357172468 60 Q5VW38,Q13432,P50897,Q14108 4 +Protein localization to phagophore assembly site 0.4510360860641075 0.701602391959018 0.4829271595136046 1.0 0.6708230357172468 5 Q7Z3C6 1 +Regulation of anion transmembrane transport 0.4703384060205033 0.7004458928246138 0.4836488843318776 1.0 0.6713991916618955 6 Q13546,Q15041,P08183 3 +Regulation of organic acid transport 0.4614050521014436 0.6980853698791049 0.4851238069095287 1.0 0.6721668963134138 9 P55011,Q15042,Q15041 3 +Regulation of b cell proliferation 0.4671118990412092 0.6973294264159541 0.4855966565332112 1.0 0.672547983735599 7 Q13315,P42574 2 +Heart process 0.3541541607455107 0.692880464955849 0.488384570035874 1.0 0.6761138288133766 35 P78417,Q99959,P0DP25,O75844,P20020,P16615,P10253 7 +Signal release 0.3294355127997751 0.6871397585441703 0.491994661909634 1.0 0.6800946067056592 58 Q5T9L3,Q13277,Q16836,Q9P2D1,P0DP25,Q15907,Q8N5M9,P50897,P16615 9 +Regulation of dendritic spine morphogenesis 0.435606197009907 0.6858012152910795 0.4928384698587096 1.0 0.6807000713982009 13 P43034,Q14444,Q9H2U1,Q9UQB8 4 +Adipose tissue development 0.4521755553501648 0.6855151919094388 0.493018877438069 1.0 0.6808059498629228 11 O15173 1 +Neural retina development 0.4643855597782009 0.6841510368130957 0.4938797968896278 1.0 0.6817078727786574 7 P54802,P20020,Q15555 3 +Pyrimidine deoxyribonucleotide metabolic process 0.4642714438270947 0.6836003061898339 0.4942275912811471 1.0 0.6819914406342974 7 Q9H773 1 +Negative regulation of endoplasmic reticulum unfolded protein response 0.4470684113700272 0.6821766651643747 0.4951272479681661 1.0 0.6825682775561147 5 Q96HY6 1 +Positive regulation of signal transduction by p53 class mediator 0.4429559903241734 0.6797157397053214 0.4966844678880393 1.0 0.6837439337972154 12 Q13535,P62841 2 +Glandular epithelial cell development 0.4274809890169169 0.6795365248800582 0.4967979730180429 1.0 0.6837439337972154 4 Q15382 1 +Nucleosome positioning 0.4573422929236483 0.6777330523102107 0.4979409657178797 1.0 0.685008095815666 9 P16403,P16402,P10412,Q92522 4 +Cell cell junction maintenance 0.4029763641669259 0.6771940353528626 0.4982828516827355 1.0 0.685159264939677 3 Q07157,Q6IQ23 2 +Adherens junction maintenance 0.4029763641669259 0.6771940353528626 0.4982828516827355 1.0 0.685159264939677 3 Q07157,Q6IQ23 2 +Regulation of response to endoplasmic reticulum stress 0.3895251607714519 0.6768227223687473 0.498518439514275 1.0 0.685159264939677 21 O95881,P46379,O76024,Q07812,Q96HY6 5 +Regulation of neuron projection development 0.3203301786447784 0.6744342180092765 0.500035294316961 1.0 0.6867374636475301 73 Q14444,O15031,Q9NQX7,Q9H2U1,Q14108,Q96G23,Q9UQB8,Q9NQC3 8 +Leukocyte apoptotic process 0.3922594243062893 0.6742395722764364 0.5001590147779673 1.0 0.6867636440621514 20 P49327,Q13546,P24390,Q07812,P17931 5 +Regulation of cholesterol metabolic process 0.4642393936714124 0.6715128991794785 0.5018938448783787 1.0 0.6887168928304047 6 P49748,P16435 2 +Lymphocyte apoptotic process 0.4149560261119175 0.6703276146816366 0.5026489671814167 1.0 0.6892073511789563 15 Q07812,P49327,Q13546,P24390 4 +Rescue of stalled ribosome 0.4639803239594456 0.6702884347234584 0.5026739382417684 1.0 0.6892073511789563 6 Q8N3C0,Q9H1I8 2 +Sensory perception of light stimulus 0.3963043878312473 0.667366637441532 0.5045379709225157 1.0 0.6911164234783146 19 Q15555,O76024,Q99797,P50897,Q9ULX3,Q13432 6 +Regulation of catabolic process 0.2777851599672248 0.6670908740885143 0.504714088992211 1.0 0.6911164234783146 330 P54646,P42858,Q969T7,Q93050,P30536,Q9Y5X3,Q16850,P09601,Q9H2U1,P21796,Q9P0J0,Q14108,P61289,Q96HY6,Q15382,Q13190,Q8NCG7,P12235,P04062,Q86UE4,Q8WTV0,P14735,Q13315,P07602,O75844,A4D1P6,P48729,Q9Y487,Q9NZ45,P05067,O15118,P42345,Q8TBX8,P10619,P27544,Q9NZJ7,P46379 37 +Positive regulation of organic acid transport 0.4608143819024434 0.6669507873928336 0.504803568688138 1.0 0.6911164234783146 7 P55011,Q15041 2 +Positive regulation of tumor necrosis factor superfamily cytokine production 0.4234010474587275 0.6666283803877779 0.5050095363568752 1.0 0.6912541880629568 14 Q92974,P05067,P09429 3 +Regulation of mitochondrial atp synthesis coupled electron transport 0.3999277005998639 0.6611730866237119 0.5085013187912346 1.0 0.6947575458333904 3 P14635 1 +Regulation of ubiquitin protein transferase activity 0.3768416080102503 0.660786905438482 0.5087489815599935 1.0 0.6949231509152117 24 Q96GX5,Q16763,Q9BTE7,Q92564,Q96GG9,P62841 6 +Positive regulation of gliogenesis 0.4504982685049684 0.6592784250214418 0.5097169941670718 1.0 0.6959556628639878 10 Q15382,P30536 2 +Response to nitric oxide 0.4559317864293216 0.6562686178720104 0.5116513056438485 1.0 0.6971461519175527 8 P46108,P50570,O95831 3 +Cellular response to reactive nitrogen species 0.4559317864293216 0.6562686178720104 0.5116513056438485 1.0 0.6971461519175527 8 P46108,P50570,O95831 3 +Atp biosynthetic process 0.3890100428847732 0.6529493919689372 0.5137889052163458 1.0 0.6993326687470776 20 O75964,P56385,P00403,P24539,Q9UJZ1,P06576 6 +Negative regulation of stress activated protein kinase signaling cascade 0.4481211419632168 0.6472394622240796 0.5174769749015957 1.0 0.7028517261339158 10 P43034,Q96J02 2 +Cardiac ventricle development 0.4198964037052359 0.6467694673282142 0.5177811559530334 1.0 0.7028517261339158 14 O75844,Q99959 2 +Nucleosome assembly 0.348540773052178 0.6459781692753271 0.5182934935504138 1.0 0.7031304330530939 35 Q9H7B4,Q99733,P07305,P16402,P55209,P10412,Q92522,P16403,Q01105 9 +Regulation of establishment of planar polarity 0.4395145135402735 0.6454582811350386 0.5186302453978033 1.0 0.7031511715496664 5 Q8TAA9 1 +Regulation of cation transmembrane transport 0.3264857333295889 0.64527156413753 0.5187512168751076 1.0 0.7031698998418624 53 P05067,P42858,P78417,Q00535,P0DP25,P46934,Q9P2D1,P50570,P21796,Q96GC9,Q07812,Q99623,Q6YHU6 13 +Extrinsic apoptotic signaling pathway 0.3319935370967932 0.6425988315471458 0.5204844414587813 1.0 0.704791354695114 48 P49327,Q13546,P42858,Q92974,Q9NQX7,Q9UGN5,Q07820,P09601,P32119,Q07812,P61289,Q9P0J0 12 +Cell death in response to oxidative stress 0.3664349316886162 0.6410287112660091 0.5215040291863984 1.0 0.7058114319082586 26 Q13546,P04062,Q9UBN7,Q07820,Q99720 5 +Regulation of dendrite morphogenesis 0.4094491168392827 0.6380986861464015 0.523409441780293 1.0 0.7068558874176338 15 Q14444,Q9H2U1,P46934,Q9UQB8 4 +Bile acid metabolic process 0.4268036733316486 0.6374311609977502 0.5238440363848091 1.0 0.7072069927254084 13 O15118,Q06520 2 +Positive regulation of small molecule metabolic process 0.4266586733378951 0.6366387210353381 0.5243601973265473 1.0 0.7072665189839267 13 P54646,P05067,P00403 3 +Negative regulation of erk1 and erk2 cascade 0.4265060938697973 0.6358050187990479 0.5249035158808091 1.0 0.7076217639935087 13 P57105 1 +Extrinsic apoptotic signaling pathway via death domain receptors 0.4005027389428009 0.6348883406724597 0.5255012418051548 1.0 0.7080091083538763 17 Q92974,P09601,P17931,Q07812 4 +Protein adp ribosylation 0.4262617682327947 0.6344703542249606 0.5257739081085704 1.0 0.7080091083538763 13 P09874,Q9UGN5,Q9ULX3,P18085,Q8IXJ6 5 +Organophosphate catabolic process 0.3362184453152308 0.6320272336851385 0.5273690817761763 1.0 0.7092626493667178 41 Q8WTV0,A8MXV4,Q8NCC3,Q8NHP8,Q9H773 5 +Adenylate cyclase inhibiting g protein coupled receptor signaling pathway 0.4477582575203126 0.6301052623226973 0.5286257169609998 1.0 0.7103861189675985 9 P07602 1 +Negative regulation of endoplasmic reticulum calcium ion concentration 0.4171374694606429 0.627836915168734 0.5301107806251428 1.0 0.7117562614806315 4 Q07812 1 +Terpenoid biosynthetic process 0.4358040577075817 0.62756027443196 0.5302920393750088 1.0 0.7117562614806315 5 P48449 1 +Monocyte chemotaxis 0.4523643122094604 0.6265538091230878 0.5309517545127167 1.0 0.7123503195895414 7 Q4KMQ2,P17931,P09429 3 +Cell activation involved in immune response 0.3357921469509065 0.62372274178558 0.5328096851426318 1.0 0.7144048128128219 40 P05067,P42345,P09429,Q9UQ84,P09601,Q99584,P11279,Q96FZ2 8 +Regulation of insulin receptor signaling pathway 0.4068609452375932 0.6230291335841003 0.5332653771255236 1.0 0.7148697455970758 15 Q9H1E3,Q8TBX8 2 +Embryonic appendage morphogenesis 0.4155220361570717 0.6221048239660439 0.5338729431818603 1.0 0.715245866304485 14 P42892,Q9P2D1 2 +Regulation of vasculature development 0.3345334932049711 0.6219244707187248 0.533991533511853 1.0 0.7152587146162032 42 P57105,Q86UE4,P52789,P09601,Q9NZ08 5 +Insulin secretion involved in cellular response to glucose stimulus 0.4396821350988886 0.6210111001451062 0.5345923197568887 1.0 0.7154792580552118 11 Q15907 1 +Response to organic cyclic compound 0.277455973901351 0.6194843102649159 0.5355973547836839 1.0 0.7159595366232955 182 P35613,P53985,P30536,Q9H4A6,P46934,P07099,Q9H2U1,P20020,Q96HY6,P42574,O75955,P16278,Q9NUD5,P09874,Q9UBN7,P0DP25,P00374,P49721,P16435,Q8IXJ6,P04062,P04818,P06493,O95071,Q00535,Q13126,Q8TB36,Q9H7B4,P05067,O15118,Q15388,P11802,P50570,O15173,Q99623 35 +Positive regulation of peptidyl tyrosine phosphorylation 0.3887058641331044 0.6189158226251729 0.5359718143571042 1.0 0.7159595366232955 19 P42345,Q13432,Q9H223 3 +Positive regulation of response to wounding 0.4482054640550557 0.6187425901567308 0.5360859477975333 1.0 0.7159595366232955 8 P32119,P42345,Q16625 3 +Fatty acid derivative metabolic process 0.3776391544669332 0.6186218296622183 0.5361655175485587 1.0 0.7159595366232955 22 P50897,A8MXV4 2 +Transition metal ion homeostasis 0.3669821139713912 0.6170971627459169 0.5371706400033087 1.0 0.7165915307383028 25 Q8N511,P30519,P09601 3 +Chaperone mediated autophagy 0.4475992269352701 0.615814748778561 0.5380167920984895 1.0 0.7172828504165559 8 P10619 1 +Regulation of calcium mediated signaling 0.4466689462359341 0.6113268466433114 0.5409832212521042 1.0 0.7196294137150431 8 P0DP25,P42858 2 +Response to activity 0.4002826125269739 0.6080057353992467 0.543183669974717 1.0 0.721974231676823 16 P54646,O43819,Q15388,Q16836,Q9UDX5 5 +Tubulin deacetylation 0.448223782277796 0.6069275034898411 0.5438990247633992 1.0 0.7224828745946207 7 P54646,P49354,Q9UBN7 3 +Face development 0.4361286106442217 0.602853390223049 0.5466062253367852 1.0 0.7246121314464614 11 O95470,O94788,Q15042,Q9P2D1 4 +Columnar cuboidal epithelial cell development 0.4495257223153717 0.6026209660912727 0.5467608694525665 1.0 0.7246707383049368 6 Q15382,P04818 2 +Protein import 0.3140702911349 0.6008396662364637 0.5479467816076768 1.0 0.7259492794083536 85 P55060,P61970,Q9NS69,Q7Z4Q2,P13473,Q15388,Q9Y512,O14737,Q92973,P06493,O75381,Q96P70,O15397,Q99623,Q99595,O14925,P52292,O60830 18 +Vascular transport 0.4278733909404161 0.5997564878782208 0.5486685358150412 1.0 0.7267587670606177 12 P11166,P53985,P55011,P08183,P30825 5 +Response to alcohol 0.3311828047962673 0.5970416440196923 0.5504795774527973 1.0 0.7281288021054738 43 P54646,P16278,P30536,Q9H4A6,P20020,Q9BRK5 6 +Positive regulation of myelination 0.3869273416982853 0.5937226299301038 0.5526976446491949 1.0 0.7297295831098523 3 O75746,Q9UPY3 2 +Dna modification 0.3494653656551524 0.5922854434704022 0.5536594617721118 1.0 0.7301272886150719 30 O75844,Q8N2A8,Q9UGN5 3 +Protein exit from endoplasmic reticulum 0.3703169655263854 0.5911162886510362 0.5544425066761343 1.0 0.7304913405746251 23 O15260,Q9Y6B6,Q8TCT9,Q9BUN8,Q9NR31 5 +Negative regulation of inclusion body assembly 0.4281638211308441 0.5910208503844795 0.554506450646389 1.0 0.7304913405746251 5 O75190,P54652,P25685 3 +Synaptic vesicle membrane organization 0.4096401516660306 0.5908760817438105 0.5546034530238924 1.0 0.7304913405746251 4 Q13277 1 +Negative regulation of epithelial cell proliferation 0.3924211105931746 0.5859828770037981 0.5578870216408345 1.0 0.7329038310324636 17 P57105,Q9Y5V3 2 +Regulation of release of cytochrome c from mitochondria 0.4325444845820111 0.5846336484250289 0.558794077469444 1.0 0.7339485060757589 11 Q96A26,O14737 2 +Cellular oxidant detoxification 0.3784597242372024 0.5844181968327221 0.5589389870004515 1.0 0.733991921692408 20 P32119,P00374,P78417 3 +Endochondral bone morphogenesis 0.4445314816989537 0.5795679707031883 0.5622059975211249 1.0 0.7373435379744842 6 O75844 1 +Cellular amide metabolic process 0.2635063525438497 0.5794728962248722 0.5622701297640638 1.0 0.7373435379744842 479 P55786,Q969T7,Q9Y619,P06280,Q9UIQ6,Q8TCT9,P51812,Q9H2U1,Q567V2,P62841,Q13510,Q14444,P42892,P67812,P49902,O95197,O15031,Q9H7Z7,O43708,A8MXV4,Q9Y3U8,Q9HCE1,P00374,P50897,P49770,P83731,P49755,Q96G23,O95470,Q9NWS8,P42766,P04062,Q7Z478,P04818,Q9NRN7,O15269,Q7Z7H8,Q53GQ0,P14735,Q9Y2R0,P98179,P62424,P62266,Q96KC8,P47914,Q8NCC3,Q14197,Q15418,Q9NSD9,Q8TB36,P05067,P42345,P55010,Q9H1I8,P78417,P17900,O60512,P78527,O14773,P62847,Q15363,P27544,O75503,Q99797,O15217,O60841,Q9H2D1,P29692,Q9NZ08,P62750,Q9NQC3 71 +Female gamete generation 0.3489793106024948 0.5794663957515991 0.5622745147705173 1.0 0.7373435379744842 29 O14965,Q9Y5A9,Q8N2A8,O95067,Q13315,Q9H6S0,P62753,P84243,Q9Y2W6,P53350,O14777,O60879,Q96GX5,Q8IXJ6 14 +Protein deglycosylation 0.4442381183988798 0.5782195464854275 0.5631159037497013 1.0 0.73811347627026 6 O60502,Q16706 2 +Negative regulation of cell death 0.2816161115579101 0.5779834270820057 0.56327530834666 1.0 0.73811347627026 225 P54646,Q15392,Q13546,P42858,Q9P032,Q86XL3,P45880,Q9H4A6,Q07820,P09601,P17931,P51812,P21796,Q9P0J0,P61289,Q96HY6,Q15041,Q92974,Q9UGN5,P32119,P50897,P16435,P12235,P04062,Q86UE4,Q9UMX5,O76024,Q01105,Q15418,P18085,O14965,O95881,P49327,O15118,Q9NVI7,P78527,Q07812,P05141,Q99623,P46379 40 +Pyrimidine deoxyribonucleoside monophosphate metabolic process 0.4068874020152888 0.5774250797063089 0.5636523361155552 1.0 0.73811347627026 4 P04818,P32321 2 +Pyrimidine deoxyribonucleoside monophosphate biosynthetic process 0.4068874020152888 0.5774250797063089 0.5636523361155552 1.0 0.73811347627026 4 P04818,P32321 2 +Dtmp metabolic process 0.4068874020152888 0.5774250797063089 0.5636523361155552 1.0 0.73811347627026 4 P04818,P32321 2 +Hydrogen peroxide metabolic process 0.4337060655510848 0.5750535641403477 0.565255071593032 1.0 0.73947443775787 10 Q15067,P00403,P32119 3 +Cell proliferation in forebrain 0.4059514558843361 0.5728671312304499 0.5667346610880055 1.0 0.7409668950108572 4 Q15154 1 +Sodium ion export across plasma membrane 0.3599766627771251 0.5714315348065898 0.5677071579300041 1.0 0.7417358449187158 2 P05023 1 +Deoxyribose phosphate metabolic process 0.3978795994998403 0.5711647447542059 0.5678879739213087 1.0 0.7417358449187158 15 P04818,P31350,P32321,P34896,Q96G03,Q9H773 6 +Cellular response to peptide hormone stimulus 0.3147148070681674 0.5708412209397892 0.5681072779810066 1.0 0.7418746185296249 66 Q12965,P43490,P46108,Q9Y5X3,Q92572,P20020,Q7L576,Q15043,O60343,P61026,Q9BSK2,P09874,P16435,P14735,O43865,Q9H1E3,Q9BZF1,Q9UQB8,O14654,P11802,P78527,Q8TBX8 22 +Somitogenesis 0.4324483821140316 0.5688287623408476 0.5694723534731352 1.0 0.7433816107163741 10 Q15363,P78527,Q13315 3 +Integrin activation 0.3816749343449158 0.5669168835660372 0.570770652780598 1.0 0.7440200682451895 3 Q96AC1,O94887 2 +Histone h3 k27 methylation 0.4372976080353608 0.5664676826176807 0.5710758960013373 1.0 0.7442701151064103 8 P16402,P10412 2 +Glandular epithelial cell differentiation 0.4226421101270431 0.5648990296757822 0.5721424437189733 1.0 0.7453212778238001 5 Q15382 1 +Regulation of transmembrane transport 0.3112553655339088 0.564780321025534 0.5722231937940117 1.0 0.7453212778238001 78 Q13546,P42858,P46934,P21796,Q15041,P0DP25,Q96GC9,P08183,Q6YHU6,Q16625,Q00535,Q9P2D1,O75844,P05067,P78417,P52789,Q07812,P50570,Q99623 19 +Negative regulation of kinase activity 0.3228433044481352 0.564187055843668 0.5726268361409872 1.0 0.7456095861522117 49 Q9H7B4,P04062,Q8TBX8 3 +Negative regulation of excitatory postsynaptic potential 0.3585180863477357 0.5636695414964594 0.5729790499226639 1.0 0.7457724203376529 2 P38919 1 +Dna methylation or demethylation 0.3662802144412256 0.5636032701028137 0.5730241608263404 1.0 0.7457724203376529 23 O75844,Q8N2A8 2 +Cellular response to oxygen containing compound 0.2808472510046226 0.5633318552435015 0.5732089303618848 1.0 0.7458649615377132 225 P54646,P43490,P30536,Q9Y5X3,Q9H4A6,Q9H2U1,Q9P0J0,P20020,Q99720,Q15043,Q9BSK2,Q92974,P32119,P00374,P16435,Q86UE4,Q8WTV0,P14735,Q13315,Q8N5M9,Q9H1E3,Q9UQB8,Q8TB36,Q9H7B4,P05067,P42345,Q8TBX8,Q15907,P27544,Q99623,Q9UNS1 31 +Dna methylation 0.3797852158180639 0.5626709053131801 0.5736589996058605 1.0 0.7461546789719835 19 O75844,Q8N2A8 2 +Exit from mitosis 0.4281583492021188 0.5624737817085657 0.5737932619652955 1.0 0.7461814080492012 11 Q16763,P83731,Q99623 3 +Regulation of transport 0.2695540080877892 0.5612164012849105 0.57465002335588 1.0 0.7469994954955 344 P55786,Q15154,P42858,Q13546,P53985,O75165,P55011,P30536,Q9Y5X3,Q9H4A6,Q16850,P09601,P46934,P17931,P21796,P20020,Q7L576,P11279,P57105,Q9C0E2,O75955,Q15041,Q8NE86,Q9Y6B6,O95613,P0DP25,Q96GC9,P50897,Q9H223,P08183,P20337,P49755,O95487,Q6YHU6,Q5T9L3,P61020,Q16625,P09429,O15260,Q8WTV0,O14737,P06493,Q99959,O95071,Q9P2D1,Q96KC8,O75844,P53367,Q8N5M9,O76024,Q9Y282,Q00535,P05067,Q16836,P78417,Q9P2W9,Q12907,P52789,Q15907,Q07812,P50570,Q03164,P05141,Q99623,Q9NR31,P16615,Q13432 67 +Negative regulation of smooth muscle cell apoptotic process 0.3805077327108381 0.5609983842212926 0.5747986386764108 1.0 0.7470446953841569 3 P32121,P26358 2 +Regulation of response to external stimulus 0.2893724892476846 0.5575478012094502 0.577153209136612 1.0 0.7493800390483294 142 P80303,Q13546,Q13277,P01889,P55011,P11279,Q9NUD5,P60900,Q8NE86,Q8NCG7,P32119,O43657,Q9NUQ9,O15360,Q96G23,P09429,P04062,Q9UMX5,Q13315,O75844,P05067,P78527,Q9NZ08 23 +Regulation of erbb signaling pathway 0.4196756032997563 0.5570038321753212 0.5775248109153388 1.0 0.7494987000086494 12 Q9NQC3 1 +Primary alcohol metabolic process 0.3875067957487865 0.5565324051070157 0.5778469481605017 1.0 0.7494987000086494 17 O94788,Q06520,P51648,Q9Y394,Q6NUM9,P30837 6 +Deoxyribonucleoside triphosphate metabolic process 0.4350705081336147 0.5559064398959124 0.5782748155925228 1.0 0.7495100591092163 8 Q9H773 1 +Regulation of rna binding 0.4325643312004208 0.5558862543178857 0.5782886155659048 1.0 0.7495100591092163 9 Q9H1E3 1 +Positive regulation of stress activated protein kinase signaling cascade 0.4115541503630113 0.5549794662897202 0.5789087054914788 1.0 0.7501577656862329 13 P05067,Q13546,P09429,O75915 4 +Striated muscle contraction 0.3545622715646656 0.5547066702826843 0.5790953129986374 1.0 0.7502514203153126 26 P78417,Q99959,P0DP25,P16615,P10253 5 +Regulation of dendritic spine development 0.3911538395269583 0.5543632284547105 0.5793302862973901 1.0 0.7504076862778275 16 Q9H2U1,Q9UQB8 2 +Sequestering of triglyceride 0.3787569302597128 0.5521478185212331 0.5808470821621698 1.0 0.7513423612992984 3 Q9BZF1,Q9BXB4 2 +Regulation of sequestering of triglyceride 0.3787569302597128 0.5521478185212331 0.5808470821621698 1.0 0.7513423612992984 3 Q9BZF1,Q9BXB4 2 +Negative regulation of dna replication 0.4260984196217378 0.5521211760433138 0.5808653344284513 1.0 0.7513423612992984 11 Q13535 1 +Amine transport 0.4340013290398488 0.5508506297198618 0.5817360736344099 1.0 0.7521876089042361 8 P55011,P20337,Q15042,Q15041 4 +Positive regulation of nervous system development 0.3247493094161022 0.5503530644070901 0.5820772345547436 1.0 0.7524804596430708 45 Q14444,Q15382,P42345,Q16706,O15031,P30536,Q13641,P55209,Q9H2U1,Q7L576,Q9UQB8 11 +Regulation of keratinocyte migration 0.4191369395913935 0.5484512550096716 0.5833820908590039 1.0 0.7537002639263666 5 P42345 1 +Keratinocyte migration 0.4191369395913935 0.5484512550096716 0.5833820908590039 1.0 0.7537002639263666 5 P42345 1 +Peptidyl arginine modification 0.4325753459359525 0.5441224569329255 0.5863572078357517 1.0 0.7560770284571041 8 Q6P2P2,Q9ULX3 2 +Regulation of dna binding 0.3492397006022428 0.5435926561565553 0.5867218145073396 1.0 0.7562516303099718 27 P09429,P09874,P07305,P0DP25,P09601,O75844,Q96HY6 7 +Respiratory system development 0.3563291106899057 0.5414994086566115 0.5881634051366436 1.0 0.7570671370158208 25 Q16706,O60476,O94788,O00203,Q9P2D1,P46379,O95487,Q9UNS1 8 +Positive regulation of cell death 0.2903055006204794 0.5334888218189443 0.5936952468785293 1.0 0.7619456698644453 131 Q13546,Q9NS69,P42858,P30536,Q07820,P09601,Q9Y5V3,P42574,Q9Y6C9,P09874,Q9UBN7,Q8IXJ6,P09429,O14737,Q9NQX7,Q13315,Q7Z3C6,Q00535,Q4KMQ2,P00403,Q96A26,P49327,P78527,Q07812,P50570,Q9NZJ7 26 +Pigmentation 0.3748095778593833 0.5316449508306703 0.5949719256057389 1.0 0.7634348407948491 19 Q8TAA9,Q15907,Q07812,O00203,O14617 5 +Base excision repair gap filling 0.4273630238442949 0.5308993967498731 0.5954884958314826 1.0 0.763644128665418 9 P28340 1 +Blood vessel remodeling 0.4153430414467441 0.5307730896906795 0.5955760301570279 1.0 0.763644128665418 5 Q9P2D1 1 +Cellular response to lipid 0.3050367715340289 0.5298919306732223 0.596186861229993 1.0 0.7639532212787999 100 Q9H7B4,O15118,Q86UE4,Q8WTV0,P30536,Q13315,Q9UBN7,P32119,O15173,Q9P0J0,P20020,Q96HY6,Q8TB36,Q99623 14 +Receptor diffusion trapping 0.352100350058345 0.5298241286583918 0.5962338743068112 1.0 0.7639532212787999 2 Q15334 1 +Neurotransmitter gated ion channel clustering 0.352100350058345 0.5298241286583918 0.5962338743068112 1.0 0.7639532212787999 2 Q15334 1 +Positive regulation of receptor internalization 0.4331191588785182 0.5276151699757505 0.5977664618126453 1.0 0.7649265839342001 6 Q8NBU5,P16885,P32121,Q96CW1,Q06787 5 +Positive regulation of neurogenesis 0.3234000529495358 0.5264696877040794 0.5985619076604032 1.0 0.7654299775418533 43 Q14444,Q15382,O15031,P30536,P55209,Q9H2U1,Q9UQB8 7 +Cellular protein catabolic process 0.2801219513079983 0.5250316187804045 0.5995612108020176 1.0 0.7655809817635415 256 Q13546,Q16740,Q9Y5X3,Q8N3C0,P46934,Q8TCT9,Q96S82,Q6NTF9,P61289,Q8WW12,Q96HY6,Q8N511,Q96RL7,P60900,Q9UBN7,P50897,P49721,Q96A33,Q9UPU5,P04062,P13473,O95628,P28072,P14735,O76024,O75844,A4D1P6,Q9H3F6,P28074,Q9UBU6,Q9BUN8,P48729,Q7L5D6,Q6ZXV5,Q16763,O14965,Q9UHG3,Q9H1I8,Q70CQ2,O14773,P46379 41 +Neutrophil activation involved in immune response 0.3957968476357326 0.5239528435175954 0.6003113390750792 1.0 0.7659426418453567 4 P51809,P12429,P11274 3 +Neutrophil degranulation 0.3957968476357326 0.5239528435175954 0.6003113390750792 1.0 0.7659426418453567 4 P51809,P12429,P11274 3 +Negative regulation of ion transmembrane transporter activity 0.405096751382387 0.5206752616320774 0.6025930105047621 1.0 0.7673593204593665 13 P0DP25,P46934,P78417 3 +Oogenesis 0.3726963126714937 0.5185504855908656 0.6040742454247838 1.0 0.7687641113800969 19 O14965,Q8N2A8,Q13315,P62753,P84243,Q9Y2W6,Q9H6S0,O60879,Q8IXJ6 9 +Neuroblast proliferation 0.4046383505530211 0.5182555397253862 0.6042799887989241 1.0 0.7687641113800969 13 Q92974,P43034,O15031,Q8NCG7 4 +Negative regulation of keratinocyte proliferation 0.4125547445255513 0.5178668256256246 0.6045511894778834 1.0 0.7689600514351369 5 Q6YHK3,Q15648,P58107,O14936 4 +Detection of abiotic stimulus 0.4218921204599346 0.5171085922108258 0.6050803559840046 1.0 0.7694363747203637 10 Q13432 1 +Somatic diversification of immunoglobulins 0.362191915408306 0.515649693464215 0.6060990961583408 1.0 0.7703316422605136 22 Q13426 1 +Response to gamma radiation 0.3762519783733342 0.5139599995424392 0.6072799572913834 1.0 0.7710857352449803 18 Q13535,P78527,Q13315,Q07812,O75844 5 +Regulation of stem cell differentiation 0.371770045163641 0.5128274204709474 0.6080720470622776 1.0 0.7717927993854286 19 Q9NX40,Q9Y6C9,P78527,Q96J02,Q9H2U1 5 +Leukocyte mediated immunity 0.3131600212362398 0.5116199695646638 0.6089170066263603 1.0 0.7725663954915267 53 P09429,P01889,Q9UQ84,P09601,Q8N5M9,Q9H2U1,Q9NUQ9,Q99584,P11279,Q96FZ2 10 +Torc1 signaling 0.4275455472154514 0.5108548772372596 0.609452679301467 1.0 0.7730965554951142 7 Q13315 1 +Plasma membrane organization 0.3516516579232887 0.5087099130496763 0.6109555729018168 1.0 0.774703472344294 25 O75955,Q7Z3C6,P50570,Q96GC9,P16615,Q9UQB8 6 +Positive regulation of ion transmembrane transport 0.3392215715840999 0.5053369915388256 0.613322165481609 1.0 0.777103697603846 29 P42858,Q15041,P78417,Q00535,P0DP25,P50570,Q07812,Q96GC9,P08183 9 +Response to interleukin 4 0.425975973225052 0.5037112509972693 0.6144643009187472 1.0 0.7782502880966645 7 P49327,P39023 2 +Natural killer cell mediated immunity 0.4090786903444997 0.502621957028016 0.6152300888853781 1.0 0.7784689246559683 12 P04439,P11279,P01889 3 +Nucleoside bisphosphate biosynthetic process 0.3386829708588165 0.501280717174543 0.6161735741508594 1.0 0.7793621807204971 29 Q8TB61,Q53GQ0,P50897 3 +Positive regulation of histone ubiquitination 0.4087617674169175 0.5004326572320917 0.6167704631914699 1.0 0.7798471997629524 5 P50750 1 +Nucleus localization 0.3934657049455048 0.500229391588307 0.6169135650669744 1.0 0.7798471997629524 14 P42345,Q96N67,Q15154,Q14204,O94901,P43034,Q5SNT2 7 +Cell death in response to hydrogen peroxide 0.4183393419239158 0.4999295932463989 0.6171246538779824 1.0 0.7799637863534902 10 Q99720,Q9UBN7 2 +Segmentation 0.3933247949743076 0.4994662431422921 0.6174509621546986 1.0 0.7802259221373257 14 Q15363,Q8N2A8,Q13315,P78527 4 +Regulation of peptidyl tyrosine phosphorylation 0.3362083602303516 0.4989976175352804 0.6177810624557005 1.0 0.7803599064974965 31 P05067,P42345,O95684,Q9H223,Q13432 5 +Fibroblast proliferation 0.377718505918888 0.4986212160458609 0.6180462559138769 1.0 0.7803770504727459 17 Q14149,P11802,P50402,P14635,Q07812,O75844 6 +Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.367668514735927 0.4969034931296728 0.6192571081049187 1.0 0.7810042558878487 3 P11940,A2RRP1 2 +Regulation of lipid biosynthetic process 0.3427798350658242 0.4963969655431023 0.6196143655660351 1.0 0.7813046631138206 27 Q13510,P42345,Q8WTV0,P49748,P30536,P16435 6 +Regulation of the force of heart contraction 0.426050610164419 0.4959968888218174 0.6198966059911355 1.0 0.781444106020016 6 P16615 1 +Acidic amino acid transport 0.4077542948391406 0.4959026116985381 0.6199631234288636 1.0 0.781444106020016 12 Q15041,O60831,P55011,Q15042,O75915 5 +Neurotrophin trk receptor signaling pathway 0.4213629121596517 0.4918480693948978 0.6228267518875066 1.0 0.7838490882021132 8 Q7L576,Q99523,P42574 3 +Regulation of neutrophil migration 0.4210987726475405 0.4906308280129631 0.6236875783387636 1.0 0.7843188582396102 8 P63000,Q8NHP6,Q8NE86,O00429,O94813,Q07021,P84095 7 +Inner ear receptor cell development 0.4230167443674361 0.490306305857886 0.6239171654999642 1.0 0.7843188582396102 7 P43034,O95487,P54802 3 +Myeloid leukocyte activation 0.3521361113961022 0.489288494258916 0.6246374656341618 1.0 0.7849236019707717 24 P09601,P05067,Q13315,Q99584 4 +Polyol metabolic process 0.3451617034096591 0.4874797844503264 0.6259183654190839 1.0 0.7857808138282051 26 P00374,P04062 2 +Negative regulation of protein containing complex assembly 0.3187114522215843 0.4843302517703998 0.6281515096793577 1.0 0.7881319706531444 43 P09429,P04062,P45880,Q9UBN7,Q9NUQ9 5 +Mitochondrial calcium ion homeostasis 0.4174681804309802 0.4840454440602689 0.6283536180334519 1.0 0.7882348387565498 9 Q8IYU8,O95202 2 +Regulation of neutrophil chemotaxis 0.4209757522641283 0.4811104848836485 0.6304379766087049 1.0 0.7902452726850662 7 P63000,Q8NHP6,Q8NE86,O00429,O94813,Q07021 6 +Response to heat 0.3175228718448869 0.4785272143967515 0.6322750092884859 1.0 0.7921456639536241 44 P42345,Q13535,Q13315,P09601,Q9H2U1,O95391 6 +Immune effector process 0.3037998938370772 0.4784693100245886 0.6323162127078761 1.0 0.7921456639536241 77 P05067,P42345,P09429,P01889,Q9UQ84,P09601,P17931,Q8N5M9,Q9H2U1,P32119,Q9NUQ9,Q99623,Q99584,P11279,Q96FZ2 15 +Attachment of gpi anchor to protein 0.4037884437110514 0.4777975400336396 0.6327943121999973 1.0 0.7924420375298439 5 Q92643,O43292 2 +Regulation of cation channel activity 0.3590502211212687 0.4772764146672398 0.6331653034567206 1.0 0.7926041055480734 21 P05067,P42858,P78417 3 +Regulation of protein dephosphorylation 0.3351925925647971 0.4750945291068623 0.6347195977797466 1.0 0.7936845176084427 29 P42345,P42858,P04062,Q86XL3,P0DP25,Q96GX5 6 +Potassium ion import across plasma membrane 0.4029413302597249 0.473968456487374 0.6355224011680645 1.0 0.7943424755171122 5 P55011,P05023 2 +Fatty acid metabolic process 0.2990721067638244 0.4718207912332092 0.6370547092658385 1.0 0.7958029701508533 104 O95470,Q13510,P54646,O14678,Q15067,Q15800,A1L0T0,P49748,Q53GQ0,Q9H7Z7,A8MXV4,P51648,Q8N4Q0,Q8NCG7,P07099,Q8NCC3,P16435,P23786 18 +One carbon metabolic process 0.3954817110752774 0.4703872656621523 0.6380783605464131 1.0 0.7969299965560644 13 P04818,P00374 2 +Oligodendrocyte differentiation 0.3601430236205752 0.4681672353847562 0.6396650008317553 1.0 0.7984557229328473 20 Q15382,P42345,Q00535,P49770,Q96P11,Q92542 6 +Appendage development 0.3643366475765989 0.4672845820753959 0.6402962857875172 1.0 0.7987878759197125 19 P42892,O75569,Q9P2D1,Q07812,O75592 5 +Oocyte maturation 0.4177483783479788 0.4666548046735928 0.6407468698751513 1.0 0.7990461725809089 7 O14965 1 +Developmental maturation 0.3148401389432943 0.4655248572999516 0.6415556402827967 1.0 0.7997030857927819 46 O75503,P05067,Q8N2A8,P04062 4 +Monosaccharide catabolic process 0.3867681528513802 0.464208160646555 0.6424986150260228 1.0 0.8003181305620276 14 P16278 1 +Cd4 positive alpha beta t cell differentiation 0.4185189892410643 0.4628316255186603 0.6434850605315308 1.0 0.8013947555907961 6 P42345 1 +Negative regulation of muscle organ development 0.3822610237494748 0.4604597577636866 0.6451862502107943 1.0 0.8025679011473279 4 Q9NQ29 1 +Limbic system development 0.3508710316621756 0.4603246883152623 0.6452831829401557 1.0 0.8025679011473279 23 O75569,Q15042,Q00535,Q07812,O14949,P43034,P42574 7 +Cellular carbohydrate metabolic process 0.3058110708212416 0.4579607843138107 0.6469806156308537 1.0 0.8042217843852363 63 P16278,P52789,Q9NUJ1,Q7LGA3,O75844,Q14108 6 +Regulation of dna helicase activity 0.359206302888835 0.4557786244265823 0.6485491767072247 1.0 0.805713687533663 3 P49736,P33993 2 +Organelle localization 0.2703743630725047 0.4528775680371219 0.6506369045174663 1.0 0.8074556292802808 192 Q15154,P42858,Q13277,Q12965,Q6PJG6,P14635,P09601,Q92572,Q9BQS8,O14617,Q86U38,Q9Y678,P62841,P62820,P11279,O15400,P61026,Q9BVK6,Q9Y6B6,Q14849,Q9HCU5,O75381,Q13190,Q9UBN7,Q96GC9,P43034,P20337,P49755,Q86Y82,O75153,Q99584,Q96N67,Q96DB5,Q13315,O94901,Q00535,O43865,Q658Y4,Q96SN8,O14777,Q9BZD4,P42345,O94832,P16615,Q9BUK6,Q96D46,O15498,Q14674,Q9UBK9,O00203,Q15907,Q15363,P50570,Q9NR31,Q9NVT9,Q9Y2T2,Q14457 57 +Regulation of glycolytic process 0.4082018366367145 0.4516140487366067 0.6515470474546348 1.0 0.8079084893041031 10 P05067 1 +Mirna loading onto risc involved in gene silencing by mirna 0.3578019635187053 0.4490485678774141 0.6533966212203526 1.0 0.8095899978187223 3 O75569 1 +Positive regulation of transport 0.2705182781029731 0.4485968761483578 0.6537224876767413 1.0 0.8096877867866901 194 P55786,Q15154,P42858,P55011,P30536,Q9Y5X3,Q9H4A6,P46934,P17931,P20020,P11279,O75955,Q9C0E2,Q15041,Q8NE86,Q9Y6B6,O95613,P0DP25,Q96GC9,P50897,P08183,P20337,P49755,Q5T9L3,Q16625,O14737,P06493,O95071,Q99959,Q00535,O76024,Q9Y282,P78417,Q9P2W9,Q12907,Q07812,P50570,Q03164,Q9NR31 39 +Sulfur amino acid metabolic process 0.3911003852075275 0.4478190308862079 0.654283807621781 1.0 0.8099246077370547 13 Q13126 1 +Cellular response to ionizing radiation 0.335796336630291 0.4460316589844373 0.6555743773085392 1.0 0.8110631719265902 27 Q9NXR7,Q13535,Q13315,P50570,O75844,Q9H1E3,P29692 7 +Embryonic pattern specification 0.4111826838429671 0.4454520358736113 0.6559931146369902 1.0 0.811298184455362 8 Q8N2A8 1 +Regulation of inflammatory response 0.3188346507814378 0.4422544314865245 0.6583051017090866 1.0 0.8133681185115846 38 P05067,P04062,P60900,Q8NCG7,O15360 5 +Response to fatty acid 0.4035986436117045 0.4416643774948576 0.6587320908672063 1.0 0.8136979235423921 11 O15228,P11802,O00767 3 +Regulation of growth 0.2833024823951283 0.4414459690663179 0.6588901690906455 1.0 0.8136979235423921 136 Q6PJG6,Q96MG7,O95684,P51812,Q9P0J0,Q7L576,Q7Z4V5,Q5BJF2,Q9BSK2,Q9BTE7,Q9UGN5,P50897,P43034,O95470,O95067,P06493,Q00535,Q9P2D1,O75844,O76024,Q15418,Q9UBU8,P05067,P42345,P11802,P50570,Q9NVI7,Q9NQC3 28 +Glial cell development 0.353235702483271 0.4404418933935786 0.6596170884194981 1.0 0.8136979235423921 21 P05067,P18074,Q00535,Q92542,Q9UPY3,P49770,Q96P11,Q13418,Q8IXJ6 9 +Regulation of binding 0.2970355041248017 0.4404344506309208 0.6596224779477624 1.0 0.8136979235423921 103 Q6IAN0,P50750,P09601,Q96HY6,O75955,P09874,P07305,O75381,P0DP25,Q8IXJ6,P09429,P14735,O75844,Q9H1E3,P48729,Q9BUN8,O14965,P05067,Q96D46,Q07812,P35269,O75503,P16615 23 +Neuron projection guidance 0.3384417837751892 0.4401726777350063 0.6598120468102817 1.0 0.8136979235423921 26 P35613,P05067,P42892,O15031,Q00535,Q9BPU6,O00264,P83731,Q7L576 9 +Negative regulation of platelet derived growth factor receptor signaling pathway 0.3340140023337189 0.4374960919774443 0.6617516096531251 1.0 0.8147288157618613 2 O14964 1 +Endocytosis 0.283877487055746 0.4374770656364928 0.6617654050610668 1.0 0.8147288157618613 131 O75165,Q9Y2T2,Q9Y5X3,P46934,P17931,Q14108,Q8IZ07,P62820,O75955,P57105,Q5VW38,P0DP25,P50897,Q9H223,P61020,O15260,Q8WTV0,Q00535,Q4KMQ2,P27824,Q08380,Q9NZQ3,Q8IYB5,Q9NX40,P05067,O15118,P02786,Q99523,P50570,Q13432,Q14457 31 +Positive regulation of protein binding 0.3499621753322066 0.4361719070277244 0.6627120088552156 1.0 0.815205299353044 22 O75955,P05067,Q96D46,P14735,Q9BUN8 5 +Positive regulation of translational initiation 0.4021865331660845 0.434912067064676 0.6636262552932339 1.0 0.8158209616391747 11 Q7Z478 1 +Negative regulation of muscle tissue development 0.376603180945653 0.4345739770815965 0.6638716873067154 1.0 0.8158209616391747 4 Q9NQ29 1 +Positive regulation of protein kinase b signaling 0.3666519843611301 0.4345408277069131 0.6638957536045706 1.0 0.8158209616391747 17 Q86UE4 1 +Dna damage response signal transduction by p53 class mediator 0.3587925112762498 0.4338009688731236 0.6644329779846498 1.0 0.8161754401975425 19 O75844,Q13535 2 +Production of molecular mediator involved in inflammatory response 0.4017401040321 0.4327822745443113 0.6651729518096934 1.0 0.8168461961356486 11 Q8IV08 1 +Response to hydrogen peroxide 0.3256489059090176 0.426758733143344 0.6695550665739192 1.0 0.8212374480108519 32 P09601 1 +Positive regulation of peptidyl serine phosphorylation 0.350448672342678 0.4229645503737329 0.6723211253767245 1.0 0.8237063526366815 21 Q9H7B4,P05067,Q96N67,Q14012,Q9UBN7 5 +Regulation of mitochondrial membrane potential 0.3503345869720612 0.4222517143921347 0.6728412982304257 1.0 0.8238821793222717 21 Q07812,Q9UJZ1,P30536,Q9BSK2 4 +Positive regulation of helicase activity 0.373810026947329 0.4219495951200544 0.6730618088914262 1.0 0.8239249941239414 4 P52701,P43246 2 +Positive regulation of catalytic activity 0.2729017520497744 0.4194832120577621 0.6748630213438385 1.0 0.8255874619795428 221 P54619,Q14012,P61088,P14635,P0CG13,P61289,Q13426,Q9P0J0,Q96HY6,Q8WVB6,Q9Y5V3,O60343,Q9H8V3,Q9BTE7,Q9Y248,Q92616,Q92564,Q15555,P0DP25,P49354,Q14691,P00374,P16435,Q96M27,Q92542,Q96N67,Q99627,P09429,Q4KMP7,Q8WTV0,Q9BXK5,Q15185,O14737,P07602,Q00535,Q96A26,Q15554,Q96GG9,Q16763,P18085,P05067,P42345,P49327,Q9BRT9,Q07812,Q66K14,Q9NZJ7,Q99623,Q13432,Q96GX5 50 +Organelle inheritance 0.4010516526300888 0.4182205919716676 0.675785841537413 1.0 0.8262460784249794 10 Q13190 1 +Sodium ion transmembrane transport 0.3496626576708912 0.4180575350823577 0.6759050516588372 1.0 0.8262460784249794 21 P55011,Q9HD47,Q14BN4,P08195,P46934,P54709,P05023,Q13557,P23634,Q96PU5,Q6P4Q7,Q9H4A3,Q4KMQ2,Q12955,Q9Y6M7,Q8N335,O43707,P50570,Q9UHD1,P46939 20 +Fatty acid derivative biosynthetic process 0.377543037310946 0.4155034305926443 0.6777734043078898 1.0 0.8276049644712268 14 Q8WVX9,Q53GQ0,O75592,P50897 4 +Endothelial cell apoptotic process 0.3723073099858016 0.415201652720377 0.6779942890423079 1.0 0.8276118147216139 4 Q4KMQ2 1 +Histone phosphorylation 0.3278192928200465 0.4145391689038302 0.6784792876562298 1.0 0.8276118147216139 28 P54646,P50750,P06493,Q13315,O75844,O14965 6 +Positive regulation of cold induced thermogenesis 0.3913477287018194 0.4142898210259427 0.6786618675734539 1.0 0.8276118147216139 12 Q16836,P23786 2 +Positive regulation of protein localization to cell surface 0.4067740960046158 0.4123090640893213 0.6801129058602888 1.0 0.8286113791784655 6 Q9HD47,Q13277,Q92544 3 +Protein localization to synapse 0.3906985693716283 0.4111277859010715 0.6809788365842357 1.0 0.8295123678607305 12 Q9UQB8 1 +Negative regulation of alpha beta t cell activation 0.3886068799211432 0.4104353266136324 0.681486636413426 1.0 0.8299768574879178 5 P09429 1 +Intermediate filament organization 0.4026775116470917 0.4075675012577408 0.6835912277534639 1.0 0.8317681506616411 8 Q99959 1 +Regulation of postsynapse organization 0.3615933590963448 0.4058150448149364 0.6848785034602694 1.0 0.8323968947639555 17 Q14444,Q9H2U1,P43034,P18085,Q9UQB8 5 +Mechanoreceptor differentiation 0.401440632777492 0.4021298485133741 0.6875884667800594 1.0 0.8341570565743667 8 P43034,O95487,P54802 3 +Microtubule anchoring at microtubule organizing center 0.3866062552962266 0.401770113271888 0.6878532191854161 1.0 0.8343239970969871 5 Q8TD16,Q15154,Q9Y496 3 +Cardiolipin metabolic process 0.4026726158012385 0.400631206094442 0.688691666782 1.0 0.8348780191065 7 Q9UJZ1,Q99623 2 +Response to uv 0.3076902004944909 0.4002966251397963 0.6889380533794585 1.0 0.8350224429767281 46 Q13535,Q96MG7,Q07812,P46934,P27544,Q9H2U1,P28340,P42574,Q9BRK5 9 +Mitochondrial genome maintenance 0.3965080420603494 0.3973220015822938 0.6911300249487708 1.0 0.8365975325057802 10 Q9BSK2 1 +Negative regulation of transport 0.2967994234391866 0.3935556661016285 0.6939091182413888 1.0 0.8389609597615254 84 P78417,Q16850,P09601,P53367,Q8N5M9,P21796,Q13432 7 +Positive regulation of nf kappab transcription factor activity 0.3223086373277884 0.3932899895572525 0.6941053109639319 1.0 0.8389609597615254 31 P05067,Q13546,Q86UE4,Q92974,P60900,Q96HY6 6 +Positive regulation of sodium ion transmembrane transporter activity 0.3845255474452593 0.3928140984883063 0.6944567909131023 1.0 0.839002167450257 5 P50570,Q12955,Q9UHD1,O43707 4 +Neurotrophin signaling pathway 0.3952786064233125 0.3917122923969576 0.6952708064157744 1.0 0.8395682577921428 10 Q7L576,Q99523,P42574 3 +Immunoglobulin production 0.3280332970918237 0.3909755196024207 0.6958153310385646 1.0 0.8399448495723071 27 Q13426 1 +Regulation of cytoplasmic translation 0.3648570636612763 0.3879428864123463 0.6980582998904374 1.0 0.8419455276688746 15 P42345,Q9H2U1,Q9H074 3 +Regulation of receptor mediated endocytosis 0.3224520612895591 0.3873256599596145 0.6985151313145508 1.0 0.8422742175093867 30 Q13432,P50897 2 +Positive regulation of mitotic cell cycle spindle assembly checkpoint 0.3654407472270935 0.3847753277354573 0.700403880039455 1.0 0.8436027171062919 4 Q5JVF3,P12270,O14777 3 +Response to peptide hormone 0.2955409288465795 0.3844379356632776 0.7006538881065636 1.0 0.8436027171062919 91 P35613,Q12965,P43490,O75150,P46108,Q9Y5X3,Q92572,P20020,Q7L576,Q15043,O60343,Q9BSK2,P09874,P49770,P16435,P14735,O43865,Q9H1E3,Q9BZF1,Q9UQB8,P42345,P11166,O14654,P11802,Q16836,P78527,Q99523,Q8TBX8 28 +Actin mediated cell contraction 0.3442137806326979 0.3843213712848454 0.7007402700367706 1.0 0.8436027171062919 21 P16615,Q9UM22 2 +Somatic diversification of immune receptors 0.3228621991523382 0.3841639157028977 0.7008569612031197 1.0 0.8436027171062919 29 P09429,Q9UQ84,P78527,Q13315,Q13426 5 +Positive regulation of protein modification by small protein conjugation or removal 0.3077679029507065 0.3841025104946258 0.7009024708417408 1.0 0.8436027171062919 42 Q96GG9,Q96MG7,Q9BTE7,P50750,P61088,Q92564,O76024,Q9BUN8,Q16763,O75592,Q96GX5 11 +Positive regulation of leukocyte migration 0.364015633141372 0.3834656699875977 0.7013745198266437 1.0 0.8440160643870228 15 P05067,P17931,P09429,Q8NE86 4 +Negative regulation of cell growth 0.3216281130776842 0.3812613091567322 0.7030093601690304 1.0 0.8456732211602525 30 P50897,Q9NQC3 2 +Cd4 positive alpha beta t cell activation 0.3957723768710828 0.3774573183154976 0.7058337775987056 1.0 0.8482444609631105 8 P42345,P09429 2 +Mononuclear cell migration 0.3404656010152838 0.3760319321015057 0.7068931568480572 1.0 0.8486809137791442 22 P05067,P09429,P04062,P55011,P17931 5 +Positive regulation of cellular amide metabolic process 0.2967335817687064 0.3752147909846756 0.7075007308454189 1.0 0.8487998032867071 66 Q9NWS8,Q7Z478,O15031,P98179,Q9Y2R0,Q9H2U1,Q567V2 7 +Semaphorin plexin signaling pathway 0.3932753331231674 0.3739371344194904 0.7084510880164583 1.0 0.8496128144023286 9 P42892 1 +Regulation of carbohydrate metabolic process 0.3173630167447138 0.3721938118912472 0.709748553075384 1.0 0.8505058446458491 33 O75844,P05067,Q14108 3 +Positive regulation of amyloid precursor protein biosynthetic process 0.3410302386285747 0.3709950364834761 0.7106412286431538 1.0 0.8510467072141236 3 Q92542 1 +Glycolytic process through fructose 6 phosphate 0.3924080727803738 0.3701244107186575 0.7112897945243593 1.0 0.8510467072141236 9 Q9BRR6 1 +Response to peptide 0.2915769989495209 0.3700163658886904 0.7113702962671746 1.0 0.8510467072141236 103 P35613,Q12965,P43490,O75150,P46108,Q9Y5X3,Q92572,P20020,Q7L576,Q15043,O60343,Q9BSK2,Q92974,P09874,P49770,P16435,P14735,O43865,Q00535,Q9H1E3,Q9BZF1,Q9UQB8,P05067,P42345,P11166,O14654,P11802,Q16836,P78527,Q99523,Q8TBX8,Q9UNS1 32 +Positive regulation of establishment of protein localization to mitochondrion 0.3821149793571186 0.3698524470570154 0.711492434601507 1.0 0.8510467072141236 12 P55786 1 +Cellular response to toxic substance 0.3216012675490493 0.369834712524467 0.7115056493067211 1.0 0.8510467072141236 28 P32119,P00374,P27544,P78417 4 +Positive regulation by host of viral genome replication 0.3790512062896796 0.3695330886897953 0.7117304144863956 1.0 0.8510467072141236 5 Q9H1E3 1 +Positive regulation of lipase activity 0.3946209826043564 0.3664870196562083 0.7140016967163334 1.0 0.8529545118974293 7 Q99623 1 +Changes to dna methylation involved in embryo development 0.31913652275379 0.3655692079282963 0.7146865554625408 1.0 0.8536172509911163 2 P26358 1 +Ensheathment of neurons 0.3274716334531137 0.3645625769340224 0.715437954192401 1.0 0.8541738847367404 26 Q9BYI3,P42345,P18074,O15228,Q9NR77,Q8IXJ6,P49770,Q96P11,Q7L576,Q13418,Q92542 11 +Dendritic spine development 0.3207905185122638 0.3640618574460879 0.715811818524219 1.0 0.8543392421163923 28 Q14444,Q9UBN7,Q00535,Q9H2U1,P43034,P18085,Q9UQB8 7 +Response to camp 0.386826856546917 0.3630855742617594 0.7165409604376314 1.0 0.854743098053397 11 P05067 1 +Positive regulation of sodium ion transport 0.3907292521852257 0.3627729635160183 0.7167744899848092 1.0 0.854866267408273 9 P50570,Q99959 2 +Aspartate family amino acid biosynthetic process 0.3739892203817389 0.3620785698060347 0.7172933175153466 1.0 0.855174191412737 13 Q13126 1 +Receptor metabolic process 0.3106861317305871 0.361779595315859 0.7175167413488617 1.0 0.8551811048895035 37 O75955,P42892,O00560,P02786,Q96J02,Q00535,P50570,P46934,P49354,Q15907,Q8IZ07,Q14457 12 +Positive regulation of epithelial cell proliferation 0.3329326622008185 0.3615731684864129 0.7176710183593524 1.0 0.8551811048895035 24 P09601 1 +Hippocampus development 0.3535820175621911 0.3611425722547909 0.7179928696854847 1.0 0.8553865669709787 17 P43034,O14949,P42574 3 +Ameboidal type cell migration 0.293991926509385 0.3608822245014564 0.718187492211626 1.0 0.8554631192399147 82 O95470,Q8WTV0,P42785,P09601,Q9NQC3 5 +Biological process involved in intraspecies interaction between organisms 0.3943398812815091 0.3606030049823358 0.7183962426172461 1.0 0.8555564689753846 6 Q96RL7 1 +Endosomal vesicle fusion 0.3381966734753475 0.3582661014218499 0.7201441838177649 1.0 0.8567578187130483 3 Q9P2R3,Q8WUH2 2 +Positive regulation of leukocyte proliferation 0.3794071844208904 0.3570482261176855 0.7210557027237825 1.0 0.8574787099082023 12 P04439,P09429,P30825 3 +Regulation of sodium ion transport 0.3493552168815877 0.3566975929988341 0.7213182076733831 1.0 0.8576354554725022 18 Q9H4A3,Q8N335,O43707,Q9HD47,Q14BN4,Q99959,P23634,O43865,P50570,P46934,Q12955,P54709,Q9UHD1,P46939,P05023,Q96PU5,Q13557 17 +Mammary gland morphogenesis 0.3758637741828048 0.3561731411426339 0.721710905012475 1.0 0.8579469128064966 5 Q07812 1 +Cellular response to topologically incorrect protein 0.3082718509509038 0.3548671824492858 0.722689095059744 1.0 0.8583907302264777 38 P46379,P57088,Q9Y4P3,Q9UBN7,O76024,Q15363,Q07812,Q9BUN8,Q96HY6 9 +Regulation of nucleotide metabolic process 0.3453242952852402 0.3544552679117002 0.7229977216942183 1.0 0.8583907302264777 19 P54646,P05067,P09874,P00403,P54619 5 +Regulation of dna replication 0.2998641305440069 0.3544523156244013 0.7229999338557973 1.0 0.8583907302264777 50 Q13535,Q9Y248,P0CG13,Q9BRT9,O75844,Q14691,Q9H1E3,Q8WVB6,Q9UNS1 9 +Cytoplasmic translational initiation 0.3388224592760332 0.3514561994907244 0.7252461268796129 1.0 0.8596577103656105 21 P42345,P55010,Q7Z478 3 +Deoxyribonucleoside monophosphate metabolic process 0.3892479854697377 0.3495839787677873 0.7266509362743365 1.0 0.8607456078712046 8 P04818,O43598,P32321 3 +Negative regulation of mapk cascade 0.3163681282375822 0.349191771656315 0.7269453431507349 1.0 0.8607456078712046 31 P57105,P04062 2 +Positive regulation of transmembrane transport 0.3129909245727654 0.3477565494500353 0.7280230237478353 1.0 0.8618594771483484 34 P42858,Q16625,Q15041,P78417,Q00535,P0DP25,P50570,Q07812,Q96GC9,P08183 10 +Response to temperature stimulus 0.2964869486973295 0.3472424075910387 0.7284092139159006 1.0 0.862161122243171 54 P42345,Q13535,P49748,Q13315,P09601,Q9H2U1,P00403,P20020,O95391 9 +Membrane protein ectodomain proteolysis 0.3870241849043646 0.3466876559224726 0.7288259848862058 1.0 0.862302114216397 9 Q8TCT9,Q9NZ08 2 +Mammalian oogenesis stage 0.3150525087514526 0.3465591251031536 0.7289225582990482 1.0 0.862302114216397 2 P62753 1 +Positive regulation of cell differentiation 0.2781293328228467 0.3455337017618934 0.7296931782876244 1.0 0.8627924890254958 126 Q13546,P30536,P17931,P51812,Q9H2U1,Q7L576,Q14444,Q15382,Q16706,Q9Y6C9,Q92974,P09874,O15031,Q9UGN5,P16435,P43034,Q8WUJ1,P09429,P55209,Q15418,O14965,Q9UQB8,P42345,P78527,O00203,P50570 26 +Meiotic sister chromatid cohesion centromeric 0.3352786693901507 0.3453077574674083 0.7298630153277081 1.0 0.8627924890254958 3 O60566,O43683 2 +Negative regulation of receptor signaling pathway via stat 0.3352786693901459 0.3453077574673868 0.7298630153277244 1.0 0.8627924890254958 3 O14964,Q8WXW3 2 +Negative regulation of receptor signaling pathway via jak stat 0.3352786693901459 0.3453077574673868 0.7298630153277244 1.0 0.8627924890254958 3 O14964,Q8WXW3 2 +Appendage morphogenesis 0.3562343790868973 0.3426074489386805 0.7318937974473427 1.0 0.864570134806384 15 P42892,Q9P2D1 2 +Regulation of transporter activity 0.298282354196739 0.3397062596610726 0.7340777472784281 1.0 0.8664750995216404 50 P05067,Q13546,P42858,P78417,P0DP25,P46934,P50570,Q96GC9,Q03164,P08183,Q6YHU6,Q99623 12 +Neuron cellular homeostasis 0.3891227947951488 0.3395110494918784 0.7342247745948807 1.0 0.8664750995216404 6 Q14203,P20020,P23634,Q00535 4 +Negative regulation of lipid metabolic process 0.3756129798829679 0.3392920123429673 0.7343897593854285 1.0 0.8664750995216404 12 Q8TBX8 1 +Cell cycle dna replication initiation 0.3890095513366354 0.3390574016283577 0.7345664882132166 1.0 0.8664750995216404 6 P33991,P49736,P33993,P25205 4 +Nadh oxidation 0.3338196673475477 0.3388870414747616 0.7346948268421833 1.0 0.8664750995216404 3 Q8N335,P43304 2 +Embryonic placenta morphogenesis 0.3707363572002999 0.3349975651022903 0.7376269229741772 1.0 0.86962052974426 5 Q15363 1 +Sequestering of calcium ion 0.3377292808176924 0.3324231050520707 0.7395697942752424 1.0 0.8717544440513995 20 P42858,P78417,Q9P2D1,P0DP25,O95202 5 +Paraxial mesoderm formation 0.311260210034999 0.3292145011632088 0.741993562973247 1.0 0.8741403519264717 2 Q96A65 1 +Mesenchyme morphogenesis 0.311260210034999 0.3292145011632088 0.741993562973247 1.0 0.8741403519264717 2 Q96A65 1 +Paraxial mesoderm morphogenesis 0.311260210034999 0.3292145011632088 0.741993562973247 1.0 0.8741403519264717 2 Q96A65 1 +Transcription initiation from rna polymerase ii promoter 0.3190342521230535 0.3285907629149472 0.7424650308494289 1.0 0.8745387780351737 27 P09429,P50750,P53999,P35269,Q9H2U1,Q9Y6J9,O75448 7 +Phospholipid metabolic process 0.2910799928479927 0.3276636679541053 0.7431659768694665 1.0 0.8748932795510296 81 Q6IAN0,Q9NPH0,P52429,O15228,O43292,Q8NF37,Q86YN1,P48651,P43034,Q96N66,Q92643,O15269,Q8WTV0,Q13315,Q8NCC3,Q9BTU6,Q99623,Q9NUQ2,Q8TBX8,Q8NHP8,Q9UJZ1,P37268 22 +Energy homeostasis 0.3824725365971129 0.3271978371620915 0.7435182566360476 1.0 0.8749940459192511 9 P42785 1 +Negative regulation of receptor mediated endocytosis 0.3728633606921998 0.3265641754053731 0.7439975430411025 1.0 0.8751551307767748 12 Q13432 1 +Regulation of response to reactive oxygen species 0.3785918306944227 0.3259223569929527 0.7444831000552103 1.0 0.8752948862580938 11 P00374,Q9UBN7 2 +Osteoclast differentiation 0.3726382333496586 0.3255274114257087 0.7447819400340827 1.0 0.8752948862580938 12 P43034,P42345,P02786,Q15904 4 +Humoral immune response 0.3726212785037293 0.3254493634750119 0.7448410004366346 1.0 0.8752948862580938 12 Q9UQ84 1 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.3678832116788371 0.3233891297075628 0.7464005608902247 1.0 0.8763429022296751 5 Q9Y5S9,P38919,P11940,A2RRP1 4 +Chromatin remodeling at centromere 0.350569063079388 0.3213686827851688 0.7479310129428476 1.0 0.877121148758356 4 P49321,P84243 2 +Lipid droplet organization 0.3809656924654833 0.3208136251078068 0.7483516334011286 1.0 0.877121148758356 9 Q15042,Q14534 2 +Microtubule anchoring at centrosome 0.350425645425737 0.3207750470856941 0.7483808704552997 1.0 0.877121148758356 4 Q15154,Q9Y496 2 +Regulation of peptidyl serine phosphorylation 0.3208267063291415 0.3199018504228023 0.7490427350934521 1.0 0.8777175763720059 26 Q9H7B4,P05067,Q96N67,Q14012,Q9UBN7,Q07812 6 +Alpha beta t cell activation 0.3487113213609757 0.3182585699139141 0.7502888080985395 1.0 0.8790207389292298 16 P42345,P09429,Q96J02,O00203,Q9UJZ1,O14617 6 +Citrulline biosynthetic process 0.3496789258610692 0.3176900022643439 0.7507200956820239 1.0 0.8792120770775372 4 P23634,P27708,P54886 3 +Citrulline metabolic process 0.3496789258610692 0.3176900022643439 0.7507200956820239 1.0 0.8792120770775372 4 P23634,P27708,P54886 3 +Positive regulation of dna biosynthetic process 0.3048620262498929 0.3152242696820004 0.7525913796645733 1.0 0.8807748588120082 37 Q13535,Q9Y248,Q13315,P0CG13,Q14691,Q8WVB6 6 +Apical protein localization 0.3282753829504548 0.3148552630456995 0.7528715501357339 1.0 0.8809168373304106 3 P18085 1 +Regulation of oligodendrocyte differentiation 0.3808370528576913 0.3145413310013446 0.753109930526382 1.0 0.8809168373304106 8 Q15382 1 +Neutrophil migration 0.3479304679589536 0.3141805406928363 0.7533839212280196 1.0 0.8809168373304106 16 P35613,Q8N5M9,Q8NE86 3 +Positive regulation of cell cycle checkpoint 0.3655474452554789 0.3139817072362045 0.7535349322371996 1.0 0.8809364377944955 5 P12270,Q8N163,O14777,Q5JVF3 4 +Membrane depolarization during action potential 0.3479276123759545 0.3104928890584981 0.7561861661849933 1.0 0.8830919420725978 4 Q12955,Q14BN4,Q9HD47 3 +Neuron projection organization 0.3221233523287201 0.3095602636192335 0.7568953778607688 1.0 0.8837313249087685 25 Q14444,P05067,Q9UBN7,Q9H2U1,P43034,Q9UQB8 6 +Regulation of embryonic development 0.3337746513767473 0.3094187439233749 0.7570030139152983 1.0 0.8837313249087685 20 P43034,P46379,Q68CQ4,Q9H2U1 4 +Regulation of exocytosis 0.3008930309805928 0.3077841459616797 0.758246586059766 1.0 0.8843932763944442 39 P0DP25,P09601,P16615,P20337,P11279 5 +Alcohol catabolic process 0.368731974959922 0.3076700532316221 0.7583334091152225 1.0 0.8843932763944442 12 Q8WTV0 1 +Multicellular organism reproduction 0.2742315318315577 0.3068054615527266 0.7589914509100795 1.0 0.8849505865088738 137 P35613,Q8N2A8,Q9BQE5,Q9H2U1,Q9H2V7,P42574,P43034,O15360,Q8IXJ6,O95470,A0AVF1,P41208,O95067,Q14320,Q13315,O94901,O14777,O14965,P05067,Q15067,P42345,Q9BTX1,Q9H6S0,O00203,Q15363,Q07812,P50570,P46379,O75592,P54619,Q96GX5 31 +Negative regulation of extrinsic apoptotic signaling pathway 0.3125881925752517 0.306459193812964 0.7592550446992545 1.0 0.8850471953840635 28 Q13546,P42858,Q92974,Q07820,P09601,P32119,P61289 7 +Regulation of proteolysis 0.2633819578744976 0.3060645018558211 0.7595555351835017 1.0 0.8850471953840635 168 Q15392,P51812,P61289,Q9P0J0,Q96HY6,Q15041,Q9UBN7,P16435,P49755,P09429,P04062,Q9BXK5,O14737,Q96KC8,P48729,Q6ZXV5,Q96A26,Q15418,O14965,P05067,Q92896,Q07812,Q9NZJ7,P46379 24 +Regulation of sodium ion transmembrane transport 0.349048316251825 0.3058108300983542 0.7597486820479167 1.0 0.8850471953840635 15 Q9H4A3,Q8N335,O43707,Q9HD47,Q14BN4,P23634,P50570,Q9UHD1,Q12955,P54709,P46934,P46939,Q96PU5,Q13557 14 +Regulation of transcription regulatory region dna binding 0.3681736871222613 0.3051385643918197 0.7602606207492719 1.0 0.8853149974800105 12 O75844,P09874,Q96HY6 3 +Multi multicellular organism process 0.3155343267820432 0.3048003271212987 0.7605182323673909 1.0 0.8853149974800105 27 P35613,P11166,Q9BQE5,P47914,Q9UIQ6,Q15363,Q96GC9 7 +Positive regulation of organelle assembly 0.3154333070554316 0.3041178825020232 0.7610380834216068 1.0 0.8856059413748154 27 Q9P2W9,Q8TBX8 2 +Multi organism reproductive process 0.263764702861318 0.3037284952700383 0.7613347468601566 1.0 0.885794079591551 167 P35613,Q8N2A8,P45880,Q9BQE5,Q9UIQ6,Q9H2U1,Q9H2V7,Q96GC9,P43034,O15360,Q8IXJ6,O95470,A0AVF1,P41208,O95067,Q14320,P06493,Q13315,O94901,P47914,O14777,O14965,P05067,Q15067,P42345,P11166,Q9BTX1,Q9H6S0,O00203,Q15363,Q07812,P50570,P46379,O75592,P54619,Q96GX5 36 +Negative regulation of signal transduction in absence of ligand 0.3791275523436737 0.3032834792856581 0.7616738352801069 1.0 0.8858744606714041 7 P32119,Q13546 2 +Vascular associated smooth muscle cell migration 0.3458041867325029 0.3018397417827403 0.7627742334023493 1.0 0.8863756395676781 4 Q96N67 1 +Regulation of muscle contraction 0.3234320647393725 0.3009070306751985 0.7634853889437232 1.0 0.8868774464542694 24 P0DP25,P16615,P20020,P78417 4 +Carnitine metabolic process 0.3782142145592565 0.2996685062478013 0.7644300235468555 1.0 0.8876640974189464 7 P23786 1 +Postsynaptic modulation of chemical synaptic transmission 0.3450087565674329 0.2986192310687569 0.7652305903475096 1.0 0.8879651872432109 4 P06730,P38919,Q7L576 3 +Mitochondrial protein processing 0.378037006854388 0.2959870853071107 0.7672399441774742 1.0 0.8890391159619611 6 Q99797 1 +Histone h3 deacetylation 0.3768163823597245 0.2941611186738301 0.7686347896916015 1.0 0.8898087930938168 7 Q9UBN7,Q8IXJ6 2 +Positive regulation of fat cell differentiation 0.3600000000000042 0.291996647471044 0.7702891872616515 1.0 0.8911561436549643 5 Q96A49,Q86X55,O96017,Q13043 4 +Regulation of phosphoprotein phosphatase activity 0.3435506227205711 0.2915251594079243 0.7706497046578913 1.0 0.8912589640403741 16 P0DP25,P42345,P42858,Q96GX5 4 +Neurogenesis 0.2660165692248692 0.290812220626914 0.7711949383963033 1.0 0.8914182113363646 300 P35613,Q15154,Q13277,P30536,Q13641,P46934,Q9H2U1,Q9BPU6,Q14108,Q8NAT1,Q7L576,P42574,O75955,P42892,Q14444,Q16706,Q15382,Q92974,O15031,Q9NR77,Q8NCG7,Q15555,Q9UBN7,Q9H9T3,Q9HCE1,P00374,P50897,P49770,P43034,P83731,O95487,Q96G23,Q96N66,Q8IXJ6,Q8WUJ1,Q96N67,P09429,P04062,O94915,Q9NQX7,P06493,O94901,Q9P2D1,P55209,O14949,Q96SN8,O00264,P18085,O14965,Q9UQB8,P05067,P42345,Q07812,P50570,Q9NZJ7,O75503,P54802,Q9NQC3 58 +T cell proliferation 0.3191442764967681 0.2904149247694354 0.7714988271683707 1.0 0.8916124170269195 25 P09429,P02786,Q96J02,Q07812,P32119,P17931,P04439,P30825,P42574,Q92542 10 +Regulation of glucose import 0.3755446877723994 0.2891774679384252 0.7724455735841895 1.0 0.8924974239138592 7 P52789 1 +Positive regulation of molecular function 0.2625608973261417 0.2874242496322527 0.7737874956563426 1.0 0.8929992167599228 322 Q13546,P42858,P50750,P14635,P0CG13,P61289,Q13426,Q9P0J0,Q96HY6,Q8WVB6,Q9Y5V3,O75955,P60900,Q9Y248,Q92974,Q9BTE7,Q92564,P09874,Q9UBN7,P07305,P0DP25,Q15555,P49354,Q14691,P00374,Q96GC9,P16435,P08183,Q8IXJ6,Q8NFQ8,Q96N67,P09429,Q4KMP7,Q86UE4,Q8WTV0,Q9BXK5,O14737,P14735,P07602,Q9BUN8,Q96A26,Q96GG9,Q16763,P18085,P05067,P42345,P49327,P78417,Q96D46,Q9BRT9,Q07812,P50570,Q66K14,Q9NZJ7,O75503,Q03164,Q99623,Q13432,Q96GX5 59 +Copii coated vesicle budding 0.3279566435891842 0.286961342072597 0.7741419204469293 1.0 0.8932511485796993 21 P62820,Q9Y6B6,Q15363,P49755,Q9NR31,O95487 6 +Pigment granule organization 0.3756194707770538 0.2867426149593861 0.7743094050644213 1.0 0.893287327009974 6 O14617,O00203 2 +Mitochondrial electron transport nadh to ubiquinone 0.3234485669011582 0.2858636326359481 0.7749825688497705 1.0 0.89374966903202 23 O43676 1 +Defense response 0.2655889351083168 0.285314253829286 0.7754033935302571 1.0 0.8940778542164025 219 Q6IAN0,Q13546,Q9P032,P01889,Q9BQE5,Q8IV08,P09601,Q9H2U1,P11279,Q9NUD5,P60900,Q92974,Q8NCG7,P42785,P32119,Q9HCE1,O43657,O15360,P09429,P04062,Q13315,O75844,Q8N5M9,Q08380,Q03518,P05067,P42345,P49327,P78527,O00203,Q99623,Q9NVI7,Q9NZ08 33 +Pancreas development 0.368834448036753 0.2832607893779838 0.7769769323865234 1.0 0.8952033738024499 11 Q5T9L3,Q15382,O76024 3 +Carbohydrate homeostasis 0.2921416278383095 0.2830535766809772 0.7771357673087746 1.0 0.8952033738024499 50 P54646,Q8NE86,P52789,P42785,O76024,Q15907,Q8N5M9,Q9H1E3,Q15043 9 +Regulation of nik nf kappab signaling 0.339004108950231 0.2827943641227589 0.7773344748440048 1.0 0.8952033738024499 17 P05067,O43657 2 +Homeostasis of number of cells 0.2896463880966252 0.2824671173811916 0.7775853569228064 1.0 0.8953351661918679 60 Q9NX40,P49327,P09429,P04062,O95067,Q9H9B4,P78527,P62847,O00203,Q07812,P09601,P32119,P05141 13 +Cell cycle dna replication 0.3356643715194853 0.281324669377388 0.7784613906230382 1.0 0.8961866044330487 18 O75844,Q14691,Q14566 3 +Arf protein signal transduction 0.357080291970807 0.2806340806661757 0.7789910734368737 1.0 0.8966390850539844 5 O95819,Q9NP61,Q92538,Q15555 4 +Regulation of endocytosis 0.2895059178836032 0.2787315026784613 0.780450884587534 1.0 0.8975313570825842 56 P61020,O75955,P57105,P05067,P0DP25,P50570,P17931,P50897,Q9H223,Q13432 10 +3 utr mediated mrna destabilization 0.3731458096664115 0.2773792662333312 0.7814889004085201 1.0 0.898411030918134 6 Q9H2U1 1 +Regulation of dna demethylation 0.3192296469215203 0.2769598057752014 0.7818109696076816 1.0 0.8986238540139441 3 Q93008,Q93009 2 +Response to radiation 0.2850529635319483 0.2761910854486207 0.78240130382991 1.0 0.8989450799856428 100 Q9NXR7,Q6PJG6,Q96MG7,P46934,Q9H2U1,Q13426,P42574,Q9BRK5,P09874,Q15555,Q13315,Q00535,O75844,Q9H1E3,P22830,P05067,Q13535,P78527,Q07812,P27544,P28340,P50570,P29692,Q13432 24 +Dna dependent dna replication 0.2864985490626051 0.2760607367556962 0.7825014167750672 1.0 0.8989450799856428 80 Q13535,Q9Y248,Q9Y619,P50750,P0CG13,Q9BRT9,O75844,P28340,Q9H1E3,Q14691,Q8WVB6,Q96QE5,Q9UNS1,Q07864,Q14566 15 +Negative regulation of growth 0.3053390788096501 0.2752783110408663 0.7831024262894717 1.0 0.8993206372613779 32 P50897,Q9NQC3 2 +Glutathione metabolic process 0.3166775708309183 0.2747212795235996 0.7835303812741179 1.0 0.8996546565040703 25 O15217,Q9H7Z7,Q8TB36,P78417 4 +Post embryonic development 0.3369365533897911 0.2720245180553688 0.7856031672676198 1.0 0.9010271772826604 17 O95470,P42345,Q13315,Q96A33 4 +Positive regulation of mononuclear cell migration 0.3690469607134213 0.271578860909222 0.7859458552929968 1.0 0.9010271772826604 9 P05067,P17931,P09429 3 +Telencephalon development 0.2929999739599718 0.2697285537321877 0.7873690917417404 1.0 0.901950251875016 46 O94901,Q9P2D1,Q00535,Q07812,O14949,P43034,P31939,Q96N66,P42574,Q9NQC3 10 +Organic hydroxy compound catabolic process 0.3417848126619662 0.2696182269912446 0.7874539763779285 1.0 0.901950251875016 15 P30837,P21964,Q06520,Q8WTV0 4 +Attachment of mitotic spindle microtubules to kinetochore 0.3693796016193739 0.2685607797337611 0.7882676969737348 1.0 0.902179445378935 8 Q96DB5,O14777,Q9BZD4 3 +Peroxisome organization 0.3657720995502634 0.263651525054107 0.7920484515232133 1.0 0.9051683240454266 10 O14678 1 +Alpha beta t cell differentiation 0.3638251686296918 0.2619831898106435 0.7933344022715467 1.0 0.9053601855071112 11 P42345,P09429,O00203 3 +Positive regulation of camp dependent protein kinase activity 0.3154362416107539 0.2615799684410025 0.793645289289209 1.0 0.9053601855071112 3 P23634,Q9Y4G8 2 +Cellular response to testosterone stimulus 0.31543624161075 0.2615799684409872 0.7936452892892207 1.0 0.9053601855071112 3 P26038,O75116 2 +Protein localization to chromosome telomeric region 0.3317945369292799 0.260719568584015 0.7943087742911079 1.0 0.9053601855071112 18 O14773 1 +Meiosis ii cell cycle process 0.335376532399307 0.2605595621202287 0.7944321774077943 1.0 0.9053601855071112 4 O60566,O43683,Q96GX5 3 +Pallium development 0.2930976012727998 0.2595799026228639 0.7951878404283814 1.0 0.9060640057112412 42 O94901,Q00535,Q07812,O14949,P43034,P31939,Q96N66,P42574,Q9NQC3 9 +Locomotory exploration behavior 0.31456084038519 0.2580754172493739 0.7963487032911176 1.0 0.9070453349184054 3 Q15334,Q05086 2 +Mitochondrial transcription 0.3665576627801831 0.2575681436685652 0.7967402179929426 1.0 0.9070453349184054 8 O00411,Q96QE5,Q9BSK2 3 +Negative regulation of cell projection organization 0.3034611921322929 0.2561628150008259 0.7978251201834203 1.0 0.9076045411307462 31 Q9NR77,Q9NQX7,P50570,P43034,Q96G23,Q9NQC3 6 +Positive regulation of locomotion 0.284811624730169 0.2551895892779239 0.7985766714997915 1.0 0.9077259935970428 91 Q13277,O95684,Q13641,P09601,P17931,Q96HY6,P06576,Q8NE86,Q92974,Q9UBN7,Q15555,Q9H9T3,Q96N67,P09429,Q8WTV0,Q13315,P05067,P42345,Q9NQC3 19 +Gpi anchor metabolic process 0.3666098640089394 0.2531196952793083 0.8001757197151456 1.0 0.9091688073659594 6 Q92643,O43292 2 +Cellular response to ketone 0.3200923121724552 0.252906463144971 0.8003404949350148 1.0 0.9091688073659594 22 P54646,Q9H7B4,Q9H4A6 3 +Visual behavior 0.3663826904960229 0.2522893290683015 0.8008174355987201 1.0 0.9091688073659594 6 P05067 1 +T cell lineage commitment 0.3494247224181995 0.2515548820330587 0.8013851361809321 1.0 0.9091688073659594 5 P42345 1 +Deoxyribonucleoside monophosphate biosynthetic process 0.3661761278476468 0.2515350616564769 0.8014004580589025 1.0 0.9091688073659594 6 P04818,P32321 2 +Neuron differentiation 0.2658440734934403 0.251207651785062 0.8016535689453583 1.0 0.9091688073659594 242 P35613,Q13277,P30536,Q13641,P46934,Q9H2U1,Q9BPU6,Q14108,Q7L576,P42574,O75955,P42892,Q14444,Q92974,O15031,Q9NR77,Q9UBN7,Q15555,Q9HCE1,P00374,P50897,P43034,P83731,O95487,Q96G23,Q8WUJ1,Q96N67,P09429,P04062,O94915,Q9NQX7,O14949,Q96SN8,O00264,P18085,O14965,Q9UQB8,P05067,P50570,Q9NZJ7,O75503,P54802,Q9NQC3 43 +Gland morphogenesis 0.3555443013612621 0.2493397914474472 0.8030979539295748 1.0 0.910334906492636 12 Q07812,Q15418 2 +Response to copper ion 0.3642395580193602 0.2486410499243425 0.803638452183373 1.0 0.910475746413552 8 O75592,P05067,P02786,P06493 4 +Positive regulation of response to reactive oxygen species 0.3319535590279973 0.2474682754169997 0.8045458406257353 1.0 0.9108747077615726 4 Q9UBN7 1 +Positive regulation of response to oxidative stress 0.3319535590279973 0.2474682754169997 0.8045458406257353 1.0 0.9108747077615726 4 Q9UBN7 1 +Autophagosome maturation 0.32604698769577 0.246859123587788 0.8050172520530099 1.0 0.911251200271149 19 P13473,Q9Y5W7,Q96GC9,Q9BQS8,P16615 5 +Regulation of neurotransmitter levels 0.3025402518703852 0.2450457585765938 0.8064210009740591 1.0 0.9124350504510352 30 O75955,P21964,Q13277,Q8NCG7,P0DP25,P50897,P16615,P20337 8 +Myeloid leukocyte migration 0.3119117852253477 0.2448302889208477 0.8065878403316422 1.0 0.9124350504510352 25 P35613,P09429,Q8NE86,Q8N5M9,P17931 5 +Reactive oxygen species biosynthetic process 0.3596978783856657 0.2447895719631572 0.8066193686883181 1.0 0.9124350504510352 11 P00403,Q9BSK2 2 +Gmp biosynthetic process 0.3596543998815167 0.2446101164570538 0.8067583301915431 1.0 0.9124350504510352 11 P31939 1 +Positive regulation of glial cell differentiation 0.3633055878081802 0.2425726332823733 0.8083364835672475 1.0 0.9137474599773088 7 Q15382 1 +Regulation of mrna binding 0.3629743595035614 0.2413468691500043 0.8092862879379814 1.0 0.9144121957840796 7 P38919,P50750,Q86X55,P60228 4 +Positive regulation of tor signaling 0.3621833871637033 0.2408018541079431 0.8097086925310923 1.0 0.9146683491804146 8 Q9H4A6 1 +Extracellular exosome assembly 0.3301225919439635 0.2405627423571667 0.8098940295107668 1.0 0.9147202446901296 4 O00560,Q92783,Q99816 3 +Erad pathway 0.290641901246536 0.2376515432188753 0.812151369835671 1.0 0.9166386805747632 40 O76024,Q8TCT9,Q6NTF9,Q9UBU6,Q9BUN8,Q7L5D6,P46379,Q96A33 8 +Positive regulation of interleukin 6 production 0.3602454127317742 0.2367601240065562 0.8128428884887935 1.0 0.9171492248149512 9 Q92974,P05067 2 +Unsaturated fatty acid biosynthetic process 0.3525325381811754 0.2364709590178212 0.8130672396722187 1.0 0.9171991106634174 12 Q9H7Z7,Q8NCG7,O95864 3 +Kinetochore organization 0.361720165498223 0.2354428223854167 0.813865052586503 1.0 0.9175677374288552 6 Q9BZD4 1 +Regulation of actin filament based movement 0.3586003913657196 0.2346883158474255 0.8144506570926577 1.0 0.9175677374288552 10 P16615 1 +Cell killing 0.323561607390165 0.2335866839708275 0.8153058664477844 1.0 0.9178647582133658 19 O15400,P01889,Q9NUQ9,P04439,P11279 5 +Tube morphogenesis 0.2751894878707846 0.2335480997953414 0.8153358237771577 1.0 0.9178647582133658 117 O95470,P57105,P35613,Q86UE4,O15031,P52789,Q96AY3,P42785,Q15363,P09601,Q9P2D1,Q07812,Q99623,Q9UNS1,Q9NZ08,Q9Y5V3 16 +Positive regulation of synapse assembly 0.3277875072971464 0.2318559320759254 0.816649912976549 1.0 0.9183987538906796 4 Q9BQT9,Q9H2P0,Q13641 3 +Positive regulation of mitochondrial fission 0.3602407627875588 0.2313050342562161 0.8170778359548208 1.0 0.9187225427579736 7 Q8NE86 1 +Positive regulation of sodium ion transmembrane transport 0.3603971962616868 0.2307318049706256 0.8175231633206894 1.0 0.9190657868271996 6 Q9H4A3,O43707,P50570,Q9UHD1,Q12955 5 +Negative regulation of intrinsic apoptotic signaling pathway 0.2988786317719055 0.2292118343203043 0.8187042749608473 1.0 0.919598153472 32 O95881,Q92974,P45880,O76024,Q9P0J0 5 +Regulation of endoplasmic reticulum tubular network organization 0.3595251748270635 0.2276435605709952 0.8199233524733698 1.0 0.9204100416293732 6 P57088,Q15041 2 +Synaptic vesicle transport 0.3504243887722819 0.2275690650472636 0.8199812714668264 1.0 0.9204100416293732 12 O00203,P50570,Q00535,Q92572,O14617,Q9Y2T2 6 +Aorta development 0.3588417510334193 0.2262176055468101 0.8210321782581824 1.0 0.9211169693503494 7 Q96AY3,Q9P2D1 2 +Regulation of neurotransmitter uptake 0.3261781544979509 0.2259213222798921 0.8212626137409811 1.0 0.9212179951056954 4 O75955 1 +Establishment of tissue polarity 0.3577169825658675 0.2240360156413647 0.8227292789914078 1.0 0.9223901467181987 8 P43034,Q8TAA9 2 +Detoxification 0.3003521885098426 0.2236116238052553 0.8230595181976701 1.0 0.9224811496591964 28 P32119,O43708,P00374,P78417 4 +Regulation of signal transduction by p53 class mediator 0.2930470199977554 0.2234885033538434 0.8231553298670389 1.0 0.9224811496591964 37 P42345,Q13535,Q13315,O75844,P62841 5 +Columnar cuboidal epithelial cell differentiation 0.3555577170112622 0.2226877838986621 0.8237785096819177 1.0 0.9227781803572456 10 Q15382,P04818 2 +Dna dealkylation 0.3579070377954348 0.2219490111090104 0.824353576539437 1.0 0.9232647498296273 6 Q93008,Q8N3C0 2 +Positive regulation of exocytosis 0.331185944363091 0.2187913322404192 0.826812599174634 1.0 0.924598547338778 15 Q7Z460,O00560,O75122,O43747,P51149,O14964,P51809,O75351,Q99816,Q00535,Q92783,O95219,P11279,Q9UN37 14 +Cell communication by electrical coupling involved in cardiac conduction 0.3563919666923182 0.2173949569929841 0.8279005609666861 1.0 0.9253421020377098 7 P0DP25 1 +Protein kinase c signaling 0.3037931675237026 0.2163941949630439 0.8286804908307459 1.0 0.9257407866583852 3 O75955 1 +Regulation of extrinsic apoptotic signaling pathway 0.2905643326549684 0.2143397530426784 0.8302821198564723 1.0 0.9272143074367208 38 Q13546,P42858,Q92974,Q9NQX7,Q07820,P09601,P32119,P61289 8 +Nuclear migration 0.3411241956433627 0.2108214451560464 0.833026603802109 1.0 0.92933025742085 13 Q15154,Q96N67,Q14204,O94901,P43034,Q5SNT2 6 +Trna transport 0.3372747971461652 0.2076526157098557 0.8355002182980258 1.0 0.9316146869110696 5 Q15388 1 +Insulin secretion 0.2974470120252634 0.2070672075140692 0.8359573716704731 1.0 0.9319339911097106 29 Q15907,Q8N5M9,Q16836,Q8NE86 4 +Demethylation 0.3213080263141593 0.2066231265713932 0.836304197605896 1.0 0.9319699536140584 18 Q16850,Q6P6C2,P16435,Q8NB78 4 +Regulation of cellular amide metabolic process 0.2575433339946929 0.2065171965137781 0.8363869333790293 1.0 0.9319699536140584 195 Q969T7,P51812,Q9H2U1,Q567V2,Q14444,O95197,O15031,P00374,P49755,Q9NWS8,Q7Z478,P98179,Q9Y2R0,Q96KC8,Q15418,P05067,P55010,Q15363,Q9NQC3 19 +Negative regulation of amyloid fibril formation 0.3207322068144217 0.2062482402732227 0.8365970074995066 1.0 0.9320457662498748 4 O15212 1 +Regulation of neuron migration 0.3524354106147982 0.2046878571066305 0.837816008171036 1.0 0.9329180178553818 8 O15031 1 +Skeletal system morphogenesis 0.3133414441694191 0.2044756017211356 0.8379818562200518 1.0 0.9329180178553818 21 O95470,O75844,Q92896,P16435 4 +Ribonucleoside triphosphate biosynthetic process 0.2970344481126216 0.2043362007797662 0.8380907825750497 1.0 0.9329180178553818 29 O75964,P56385,P00403,P24539,Q9UJZ1,P06576 6 +Regulation of mitochondrial fission 0.3510513290855789 0.2019063440491499 0.8399899423845856 1.0 0.9345564601437184 9 Q9NUQ9,Q8NE86 2 +Positive regulation of wnt signaling pathway 0.3127732221114523 0.2013793400631234 0.8404019685396529 1.0 0.934856368461977 21 Q5T9L3,Q9H2V7 2 +Negative regulation of transferase activity 0.2807686895526682 0.2011856025357009 0.8405534488453039 1.0 0.934866395139472 64 Q9H7B4,P04062,O95684,Q8TBX8,P27544 5 +Positive regulation of cell cycle g2 m phase transition 0.3272005375337488 0.2003373880125088 0.841216723794477 1.0 0.9352870453302876 15 P05067,P06493,P14635 3 +Cell differentiation involved in embryonic placenta development 0.2993872191421209 0.2001293733572817 0.8413794014187574 1.0 0.9353094413196488 3 O75190,Q13043 2 +Microtubule organizing center localization 0.3383595727328153 0.1990667258473815 0.8422105492174632 1.0 0.9359162784022004 13 P43034,O14965 2 +Dna geometric change 0.2807884798465841 0.1981065782063246 0.842961678171416 1.0 0.936592369143385 54 P09429,P18074,O15347,Q9Y248,Q96RR1,Q8N3C0,P0CG13,Q9P2D1,Q9H4L7,Q9BRT9,P40937,Q9H2U1,Q14691,Q9HCK8,Q86WJ1,Q8WVB6,Q2NKX8,Q14566 18 +Pathway restricted smad protein phosphorylation 0.3343065693430691 0.1973695246532279 0.8435383763315576 1.0 0.9370744583524092 5 O00560,P33981,P67870,Q9Y4E8 4 +Response to topologically incorrect protein 0.2806255524926586 0.1965994174521464 0.8441410265201821 1.0 0.9375852092121588 54 Q15629,P46379,P57088,Q9Y4P3,Q9UBN7,O76024,Q15363,Q07812,Q9BUN8,Q96HY6 10 +Positive regulation of intracellular protein transport 0.2809707769488735 0.1962481682290187 0.8444159281978894 1.0 0.93768869442629 58 P55786,Q9C0E2,Q15154,Q7Z6Z7,Q14012,O95613,Q9Y6B6,O14737,P06493,O95071,P50402,Q00535,Q9Y282,Q92544,Q9NR31 15 +Cellular amino acid biosynthetic process 0.2914375703475567 0.1950101272558402 0.8453850194250885 1.0 0.93833161323874 35 Q13126,P00374,A1L0T0 3 +Phospholipid biosynthetic process 0.2806091407215133 0.19333109867791 0.8466996725133331 1.0 0.9392446851663412 60 Q6IAN0,Q92643,O15269,Q9NPH0,P52429,O15228,Q13315,Q9NUQ2,Q8TBX8,O43292,Q9BTU6,P48651,Q86YN1,Q8NF37,Q96N66 15 +Positive regulation of growth 0.2802302095880628 0.1914393613052378 0.8481813844259465 1.0 0.9398480215457548 55 Q6PJG6,Q9BSK2,O95684,Q9UGN5,Q9P2D1,O76024,P51812,Q7L576,P43034,Q7Z4V5,Q15418 11 +Mrna splice site selection 0.3109266242603269 0.1913784637802182 0.8482290916338289 1.0 0.9398480215457548 21 O95391,Q9UKA9,Q9UHX1 3 +Regulation of mda 5 signaling pathway 0.2967610154654322 0.1906617837094548 0.8487905815518433 1.0 0.9398480215457548 3 O75179,Q07021 2 +Mda 5 signaling pathway 0.2967610154654322 0.1906617837094548 0.8487905815518433 1.0 0.9398480215457548 3 O75179,Q07021 2 +Release of cytochrome c from mitochondria 0.3250467415873526 0.1905226355915877 0.8488996073912967 1.0 0.9398480215457548 15 Q96A26,O14737 2 +Base excision repair 0.3180146578839566 0.1901944679705363 0.8491567459224902 1.0 0.939875371657128 18 P28340,Q9UGN5 2 +Neurotransmitter transport 0.3050346103142317 0.1895436303185325 0.8496667627554899 1.0 0.939875371657128 24 O75955,Q13277,P0DP25,P50897,P16615,P20337 6 +Intraciliary transport 0.3468373010117579 0.1864797176442035 0.852068582858494 1.0 0.9415145402702236 9 A0AVF1,Q15154 2 +Regulation of striated muscle cell differentiation 0.3403795848527857 0.1864057086010999 0.85212661607206 1.0 0.9415145402702236 12 Q9UGN5 1 +Positive regulation of cytoplasmic translation 0.3447471057421749 0.1852464381032948 0.853035747013319 1.0 0.9415661484623064 11 Q9H2U1,Q9H074 2 +Regulation of wound healing 0.3169685758954458 0.1850353314175526 0.8532013235751805 1.0 0.9415661484623064 18 P55011,P42345,Q16625,P32119 4 +Respiratory gaseous exchange by respiratory system 0.3446833328683975 0.1850021383819572 0.8532273583402745 1.0 0.9415661484623064 11 Q7KZN9,O00203,Q16706,P10253 4 +Golgi to endosome transport 0.346395350345315 0.1848824634792369 0.8533212259837453 1.0 0.9415661484623064 9 Q96RL7 1 +Negative regulation of protein polyubiquitination 0.3142169021291001 0.1835670362182747 0.8543531249120893 1.0 0.9422294463316184 4 O95071 1 +Negative regulation of protein k63 linked ubiquitination 0.3142169021291001 0.1835670362182747 0.8543531249120893 1.0 0.9422294463316184 4 O95071 1 +Imp metabolic process 0.3393858374441799 0.1824499984969319 0.8552295910822589 1.0 0.9427207419253794 12 P31939 1 +Regulation of anatomical structure morphogenesis 0.2604968947410506 0.1818218313220824 0.855722551172911 1.0 0.9427890162519544 158 Q8N2A8,P55011,P46934,P09601,Q9H2U1,Q7L576,Q9Y5V3,P57105,Q14444,Q9Y6C9,Q8NE86,O15031,Q9HCE1,Q9NUQ9,P43034,O95487,Q99536,Q86UE4,O75844,O14965,Q9UQB8,P52789,P78527,Q8TAA9,P50570,Q99623,Q9NZ08,Q9NQC3 28 +Negative regulation of hydrolase activity 0.2765232717640934 0.1799252411421992 0.85721125900369 1.0 0.94395373075721 70 O75190,Q15392,P05067,Q15041,Q92530,Q15418,Q99523,Q15363,P17931,P51812,P16435,Q15554,P49755,Q96GX5,Q15043 15 +Cellular response to acid chemical 0.320573577753466 0.1794593751464926 0.8575770133802116 1.0 0.9439554052414972 16 Q9UQB8 1 +Positive regulation of double strand break repair via nonhomologous end joining 0.3289617467175131 0.1793102720699755 0.8576940816239373 1.0 0.9439554052414972 5 P78527,Q96T60 2 +Glycerolipid metabolic process 0.2764119201140823 0.1782193764227627 0.8585506931328526 1.0 0.944415608536292 73 Q6IAN0,Q9NPH0,P52429,O15228,Q8NCG7,O43292,P48651,Q8NF37,P43034,Q96N66,Q92643,Q8WTV0,Q13315,Q9BTU6,Q8NCC3,Q9NUQ2,Q8TBX8,Q99623,Q9UJZ1 19 +Response to light stimulus 0.2779320022689031 0.1780783890926902 0.8586614137607662 1.0 0.944415608536292 66 P22830,P05067,Q13535,Q96MG7,P09874,Q15555,P50570,P46934,P27544,Q9H2U1,Q07812,P28340,Q13432,P42574,Q9BRK5 15 +Regulation of protein k63 linked ubiquitination 0.3442854375153946 0.1759354272350182 0.860344672528097 1.0 0.9459754928165838 6 P61088,O95071 2 +Positive regulation of protein polyubiquitination 0.3117879539345177 0.1753566647059327 0.8607993894705162 1.0 0.9462057315470304 4 P61088 1 +Signal transduction by p53 class mediator 0.2799747604601231 0.1741170805430508 0.8617734499034007 1.0 0.946718335255258 50 P42345,Q13535,Q13315,O75844,P46379,P62841 6 +Ear development 0.3022371799957208 0.1734273214439171 0.8623155510731915 1.0 0.9470283103591268 24 P42892,Q9P2D1,P54802,P43034,O95487,Q9Y6M7 6 +Response to amino acid starvation 0.3321403881156289 0.1732476782956861 0.8624567483550964 1.0 0.9470283103591268 13 Q92616,P49327,P42345 3 +Regulation of myelination 0.3422382555401504 0.1722996606217203 0.863201951147645 1.0 0.9475787315296124 10 P42345,Q7L576,Q96P11,Q8IXJ6 4 +Copii coated vesicle cargo loading 0.3423011263495349 0.1702753798534111 0.8647935725326636 1.0 0.9483664091289122 9 Q9NR31,O95487 2 +Cellular response to reactive oxygen species 0.2888099508523629 0.1698595514461755 0.8651205920520677 1.0 0.9483664091289122 34 Q99720 1 +Regulation of peptide transport 0.2993253932551685 0.168891194166875 0.8658822257359715 1.0 0.9490427869182304 25 Q8N5M9,Q16836,Q9P2D1,Q8NE86 4 +Regulation of dna templated transcription initiation 0.3201632053115676 0.168693839425089 0.866037464759752 1.0 0.9490544161244978 15 P09429,P11802,P53999,Q9H2U1,Q9NVC6,O75448 6 +Non canonical wnt signaling pathway 0.3248810038586903 0.1659275700867687 0.8682139504441526 1.0 0.950487144280035 5 Q8TAA9 1 +Modulation by host of viral genome replication 0.3413144712205832 0.1656057663565814 0.8684672090629051 1.0 0.950500353602073 7 Q9H1E3 1 +Regulation of reactive oxygen species biosynthetic process 0.3407375705820941 0.1647886559336187 0.8691103332247683 1.0 0.9509924973521644 9 Q9BSK2 1 +Endosome organization 0.2906448028575976 0.1609846291145961 0.8721055069235151 1.0 0.953633783774722 28 P61020,Q9BTU6,Q14108,O75165 4 +Regulation of mitotic recombination 0.3071734526186865 0.160134991667115 0.8727747374723234 1.0 0.9542065690258892 4 Q15554 1 +Replication fork processing 0.3377689970237432 0.1590300378232834 0.8736452082169255 1.0 0.9544886633762066 11 Q9H1E3,Q13535 2 +Regulation of telomere capping 0.3377658513651862 0.1590184580093439 0.8736543314814862 1.0 0.9544886633762066 11 Q15554,Q13315,Q96T60 3 +Regulation of heart rate 0.3159525624168957 0.1584625213179735 0.8740923511377126 1.0 0.9545338672267716 16 P0DP25,P16615 2 +Cell junction disassembly 0.3223108293466761 0.1576828634302978 0.8747067045499655 1.0 0.9548869398198092 5 Q15555 1 +Nucleoside triphosphate biosynthetic process 0.2870228400383083 0.1574267306321399 0.8749085481096686 1.0 0.95494841861205 34 O75964,P56385,P04818,P00403,P24539,Q9UJZ1,P06576 7 +Regulation of cell activation 0.2745287017753835 0.1542869734600082 0.8773834680066201 1.0 0.9565360221065696 69 P09429,Q13315,P78527,O00203,Q9BWH2,P09601,P17931,P32119,Q9NUQ9,O96005,O15360,Q15418,P11279,P30825,Q96FZ2 15 +Histone h4 deacetylation 0.3206889506169362 0.1525543976836757 0.8787496893164946 1.0 0.957707268110752 5 Q8IXJ6 1 +Dna replication independent chromatin organization 0.3368709587816909 0.1512050508339771 0.8798139661173403 1.0 0.958389649014274 7 P49321,P84243,O14929 3 +Regulation of cell development 0.2758249112242354 0.1500111113649991 0.88075584885916 1.0 0.9592476483587006 92 Q15154,P30536,Q9H2U1,Q7L576,Q14444,Q15382,Q16706,O15031,P43034,Q96G23,Q8IXJ6,Q96N67,Q9P2D1,P55209,O14965,Q9UQB8,P42345,P78527,P50570,Q9NQC3 20 +Intra golgi vesicle mediated transport 0.3136592624882027 0.148252739128412 0.8821433118199431 1.0 0.9603047514109068 16 O95249 1 +Leukocyte proliferation 0.281783491442657 0.1482348518457515 0.882157427842875 1.0 0.9603047514109068 38 P09429,P04062,P02786,Q13315,Q96J02,Q07812,P32119,P17931,P04439,P30825,P42574,Q92542 12 +Response to endoplasmic reticulum stress 0.2754431308929198 0.1479315134799916 0.882396817653536 1.0 0.9603523116954378 83 Q9Y4P3,Q8TCT9,Q6NTF9,Q96HY6,Q5VYK3,O75955,Q9H3N1,Q96A33,O76024,Q9UBU6,Q6ZXV5,Q9BUN8,Q7L5D6,O95881,P46379,P57088,Q15363,Q07812,P16615 19 +Intrinsic apoptotic signaling pathway 0.2753234546625848 0.147808604042391 0.8824938188850182 1.0 0.9603523116954378 82 O95881,Q92974,Q13315,P45880,P78527,Q07820,P09601,Q07812,O76024,Q9P0J0,P46379,P42574 12 +Protein maturation 0.2729337220763878 0.1471232627813378 0.8830347286289322 1.0 0.960559954566609 71 P42892,Q15392,P67812,Q9NRN7,Q92896,Q86UY6,O76024,Q8TCT9,O75844,Q9H9S5,O75503,Q99797,Q9UJZ1,P42574 14 +L glutamate transmembrane transport 0.3353016767262389 0.1462167820634471 0.8837502577690823 1.0 0.9610820668678683 7 O60831,O75915,Q15041 3 +Granulocyte migration 0.3060461540176878 0.1445946156325112 0.8850309486593035 1.0 0.96231534135913 19 P35613,Q8N5M9,Q8NE86 3 +Negative regulation of transporter activity 0.3143648853635007 0.1435718159991658 0.8858385976147769 1.0 0.9630339426024132 15 P0DP25,P46934,P78417 3 +Cellular response to estradiol stimulus 0.2827545958564412 0.1431532217934927 0.8861691728262155 1.0 0.9632337439267228 3 Q14103,O95831 2 +Positive regulation of reproductive process 0.3344225950848185 0.1428475700885502 0.8864105667943822 1.0 0.9633365583479192 8 Q9H6S0,O14965,Q8IXJ6 3 +Cellular glucose homeostasis 0.2828768430986628 0.1407370843483988 0.8880776475779859 1.0 0.9647245086402396 36 Q15907,Q8N5M9,Q9H1E3,P52789 4 +Regulation of transferase activity 0.2520219994026182 0.1406724192572621 0.8881287346381723 1.0 0.9647245086402396 186 P42858,O95684,P14635,P0CG13,Q8WVB6,Q9Y5V3,P42574,P62841,Q9Y248,Q92564,P0DP25,Q14691,P04062,O95067,Q13315,A4D1P6,Q96SN8,Q96GG9,Q16763,Q9H7B4,P05067,P42345,Q9BRT9,Q8TBX8,P27544,Q99623,Q13432,Q96GX5 28 +Double strand break repair via nonhomologous end joining 0.2920546590366497 0.1394368096418236 0.8891049865704996 1.0 0.9649169916512912 26 P78527,P09429,Q13315,Q13426 4 +Peptidyl tyrosine modification 0.2780998758803954 0.1393314835916626 0.8891882122089847 1.0 0.9649169916512912 43 P05067,P42345,O95684,Q9H223,Q13432 5 +Regulation of dendrite extension 0.3000583771161783 0.1376541137767502 0.8905137859595018 1.0 0.9658762749530994 4 Q9Y263,Q96PU5,O60271 3 +Positive regulation of amyloid precursor protein catabolic process 0.3322066728921063 0.1365301991817084 0.8914021525727382 1.0 0.9664032784850962 7 Q96P70 1 +Regulation of exit from mitosis 0.3154808617783874 0.136480437990928 0.8914414880631343 1.0 0.9664032784850962 5 Q99623 1 +Nucleoside phosphate biosynthetic process 0.2743954800201891 0.1349251937855528 0.8926710199287355 1.0 0.9672568085819622 94 O75964,P43490,Q8WVC6,Q8TB61,Q53GQ0,P50897,P00403,P24539,P31939 9 +Exploration behavior 0.3147445255474495 0.1342569136048662 0.8931994226755422 1.0 0.967509840144752 5 P38919,Q05086,Q15334,P80404 4 +Neurotransmitter metabolic process 0.3301448118828513 0.132020773401123 0.8949678607675722 1.0 0.9689455704267956 6 Q8NCG7 1 +Regulation of t cell activation 0.282462856726541 0.1315654812235785 0.8953279901224358 1.0 0.9690157135384172 35 P09429,O15360,Q96J02,O00203,P32119,P17931,Q9NUQ9,O96005,P04439,O14617,P30825,P42574 12 +Extracellular vesicle biogenesis 0.3306050862320891 0.1304994249828237 0.8961713090499832 1.0 0.969614569158054 9 O00560,P51149,O14964,O75351,Q99816,Q92905,Q92783,Q9UN37 8 +Positive regulation of exosomal secretion 0.3305084745762756 0.1303056721841074 0.896324592580426 1.0 0.969614569158054 8 O00560,P51149,O14964,O75351,Q99816,Q92783,Q9UN37 7 +Regulation of exosomal secretion 0.3305084745762756 0.1303056721841074 0.896324592580426 1.0 0.969614569158054 8 O00560,P51149,O14964,O75351,Q99816,Q92783,Q9UN37 7 +Regulation of dendrite development 0.2990975101177339 0.1296616912678988 0.8968340925760423 1.0 0.9698147635608534 21 Q14444,P46934,Q9H2U1,Q7L576,Q9UQB8 5 +Response to nerve growth factor 0.3110256108847126 0.129511365125038 0.896953032619753 1.0 0.9698147635608534 15 P05067,Q15057,Q99523 3 +Heart morphogenesis 0.2841444399949973 0.1290307611030606 0.8973333084376269 1.0 0.9699210277632732 32 Q99959,Q9P2D1,Q15363,O75844,Q9NQC3,P10253 6 +Negative regulation of gtpase activity 0.3300484108339077 0.1286806722040372 0.8976103295895257 1.0 0.9699210277632732 9 Q15363,Q9H6U6,P35241 3 +Transport along microtubule 0.2732780114323417 0.1286399565008588 0.8976425482484545 1.0 0.9699210277632732 65 Q15154,P42858,Q9Y366,O43805,Q92572,P78537,Q9BQS8,Q9Y678,O14617,P11279,P62820,Q14204,O75381,Q9UBN7,P43034,A0AVF1,Q13409,O94901,Q15554,P05067,Q9UPW5,Q9UBK9,Q9Y496,O00203,Q9Y2T2 25 +Regulation of leukocyte mediated immunity 0.2824704796196154 0.1262809885602267 0.8995095047082196 1.0 0.9717782959985736 34 P09429,P01889,P09601,Q9H2U1,Q9NUQ9,P11279,Q96FZ2 7 +Adaptive immune response 0.2752357083548133 0.1227139864997172 0.9023335879542748 1.0 0.9740274723072792 47 P42345,P09429,Q03519,P01889,Q9UQ84,Q9NUQ9,Q03518,Q9NZ08,Q96FZ2 9 +Protein n linked glycosylation 0.3058267496194819 0.1223270694940194 0.9026399946271032 1.0 0.9741816820311257 17 Q9BT22,Q2TAA5,Q86YN1 3 +B cell activation 0.2758956393851733 0.1221586633611545 0.9027733630648088 1.0 0.9741816820311257 41 P55327,Q9UQ84,Q5HYI8,Q13315,P78527,Q07812,P05141,Q99623,Q96FZ2 9 +Negative regulation of lipid biosynthetic process 0.3279144454580082 0.1217728629836929 0.9030789061793384 1.0 0.9743511644769512 9 P49748 1 +Positive regulation of muscle cell differentiation 0.3275572003026739 0.1206264361621092 0.9039869287069752 1.0 0.9746909999000096 9 Q9UGN5 1 +Rhythmic process 0.2724607550357452 0.12056346996308 0.9040368044680585 1.0 0.9746909999000096 65 P54646,O95470,P42345,P04818,P43490,P06493,P78527,Q00535,P54802,Q03164,Q9UNS1,O75592,Q9Y5V3,P42574 14 +Negative regulation of homotypic cell cell adhesion 0.2754595856434343 0.1204799193561575 0.9041029857999 1.0 0.9746909999000096 3 P80404,P35241 2 +Tubulin complex assembly 0.3100729927007349 0.1204375320760406 0.904136561473843 1.0 0.9746909999000096 5 O75347,Q9BTW9,P17987,Q15813 4 +Positive regulation of alpha beta t cell differentiation 0.3255728909787834 0.1187082912939543 0.9055064674978024 1.0 0.9760074638174407 6 O00203 1 +Nucleotide excision repair 0.2939631682120461 0.1180465206147043 0.906030797422881 1.0 0.9764122339774912 23 P28340,P41208 2 +Negative regulation of leukocyte cell cell adhesion 0.308018375326361 0.1171119102030533 0.906771371707815 1.0 0.9770498753935438 15 P32119,P17931,P09429,P42574 4 +Actin filament based transport 0.326220403390815 0.1163621617154632 0.9073655222093624 1.0 0.9773331985888868 9 O94832,Q12965,Q9UH99,O43707,O00159,O43795,Q8WXH0,Q9UM54 8 +Regulation of cilium assembly 0.3023305642779663 0.1160283557669674 0.90763006891202 1.0 0.9773331985888868 18 P42858,Q9Y277,Q15555,P50570,Q66K14 5 +Ribose phosphate biosynthetic process 0.2719739747306095 0.1141089045321553 0.9091514635376188 1.0 0.978650246675501 80 O75964,Q8WVC6,Q8TB61,Q53GQ0,P50897,P00403,P24539,P31939 8 +Negative regulation of endocytosis 0.3066227075511455 0.1114435325099109 0.9112646410840066 1.0 0.9804424618450978 15 Q13432 1 +Glucose import 0.3242500667185354 0.1102506227610606 0.9122106157798652 1.0 0.9812993542208978 10 Q16625,P11166,P52789,Q99523 4 +Scarna localization to cajal body 0.3062773722627784 0.1095789476868509 0.9127433074101085 1.0 0.9816605672209844 5 P17987,P78371,O60832,Q9BUR4 4 +Regulation of developmental growth 0.2724516089649045 0.1094499806633973 0.9128455929872672 1.0 0.9816605672209844 50 O95470,P05067,P06493,Q9UGN5,Q00535,Q9P2D1,O75844,P50570,P43034,Q7L576,Q9NQC3 11 +Regulation of alpha beta t cell differentiation 0.3235352048654545 0.1087941811031204 0.9133657392306328 1.0 0.9820589842424072 8 P09429,O00203 2 +Regulation of protein localization to cell surface 0.3108807646534687 0.1085602432185843 0.9135512956357053 1.0 0.9820975756817656 14 Q15907 1 +Cell cell signaling 0.2521079205229568 0.1074796977395038 0.9144084308719752 1.0 0.982448968323552 195 P54646,Q13277,P43490,Q9UIQ6,P51812,Q9H2V7,P52292,P57105,Q9NR77,Q8NCG7,P0DP25,P50897,Q5T9L3,Q99959,Q9P2D1,Q8N5M9,P48729,Q15418,Q9UQB8,P05067,Q16836,Q70CQ2,Q15907,P16615,Q13432 25 +Membrane docking 0.2842874667047462 0.1073972065211719 0.9144738705635898 1.0 0.982448968323552 27 O15400,Q13277,O15498,Q13190,O43865,Q96GC9,P16615,P20337,Q86Y82 9 +Substantia nigra development 0.3023859686466444 0.1073761132746166 0.9144906037778278 1.0 0.982448968323552 17 P0DP25,P14854,P24539,Q8IXJ6 4 +Regulation of ubiquitin protein ligase activity 0.3147287477154262 0.1058829967659461 0.9156751848383426 1.0 0.9834141674155816 13 P62081,Q16763,P61927,Q96GX5,P62841 5 +Ventral spinal cord development 0.3048175182481807 0.105491810942576 0.9159855676543758 1.0 0.9835865316557052 5 Q8NCM8,Q96KG9,Q9ULW3,Q14203 4 +Post golgi vesicle mediated transport 0.2730044027456965 0.1045585152958059 0.9167261342013096 1.0 0.9839582473924464 47 O15127,Q96RL7,Q9H4A6,Q99523,P50570,Q92572,Q96KP1,Q96A65,O14617,P11279 10 +Positive regulation of proteolysis 0.271873792237047 0.1042466110037533 0.9169736452148712 1.0 0.9840034439738324 92 P05067,P09429,P04062,Q96HY6,Q9BXK5,O14737,Q07812,Q9NZJ7,P61289,Q9P0J0,P48729,Q6ZXV5,Q96A26,P46379,O14965 15 +Cardiac chamber development 0.2992683364905284 0.1023885549744056 0.918448267736106 1.0 0.985139131644656 18 O75844,Q99959 2 +Very long chain fatty acid metabolic process 0.3214083802361573 0.1018537351121934 0.9188727729361484 1.0 0.985396819089231 11 Q9P035,Q15067,Q9NZ01,O14678 4 +Dendrite morphogenesis 0.2791264768927164 0.099903517353474 0.9204209238799952 1.0 0.9867345372489018 33 Q14444,Q9UBN7,Q13641,P46934,Q9H2U1,P43034,Q9UQB8 7 +Regulation of receptor signaling pathway via stat 0.3206505446146789 0.0990345466743608 0.9211108406421687 1.0 0.987312861204494 9 Q9NX40,Q9H490,Q00535 3 +Receptor localization to synapse 0.3204868132021924 0.0988206414143431 0.9212806792325774 1.0 0.9873336301035722 11 P57105 1 +Homologous recombination 0.3205413228966968 0.0983759988242409 0.9216337323839208 1.0 0.987550710630844 10 Q9H1E3 1 +Positive regulation of binding 0.2695141214590967 0.0962577555746593 0.9233158614026856 1.0 0.9891916216366404 54 O75955,P05067,P09429,Q96D46,P09874,P50750,P07305,P14735,P0DP25,O75503,Q9BUN8,Q96HY6,Q8IXJ6 13 +Blood vessel morphogenesis 0.2711700655928539 0.0959548896011783 0.9235564000583044 1.0 0.9892878056125682 89 O95470,P57105,P35613,Q86UE4,P52789,Q96AY3,P42785,Q9P2D1,P09601,Q07812,Q9NZ08 11 +Peroxisome proliferator activated receptor signaling pathway 0.3157126168224354 0.091527499555768 0.9270734564518176 1.0 0.9925691011970674 6 O43707,Q15120,Q01469,Q96EK7,Q15648 5 +Microtubule based transport 0.2692003464221218 0.0906411413305297 0.9277777404099768 1.0 0.9931610982985754 66 Q15154,P42858,Q9Y366,O43805,Q92572,P78537,Q9BQS8,Q9Y678,O14617,P11279,P62820,Q14204,O75381,Q9UBN7,P43034,A0AVF1,Q13409,O94901,Q15554,P05067,Q9UPW5,Q9UBK9,Q9Y496,O00203,Q9Y2T2 25 +Cardiac muscle cell action potential 0.2943228421347049 0.0899941646388381 0.9282918519570088 1.0 0.9935493610409216 19 P0DP25,P16615 2 +Rig i signaling pathway 0.3137942803073367 0.0884884863646826 0.929488434991448 1.0 0.994667826225356 12 Q9NUD5 1 +Secretory granule organization 0.298255177295584 0.0877386956406623 0.9300843635279072 1.0 0.995143256721038 5 P43034,P78537 2 +Establishment of organelle localization 0.2564550139088444 0.0857462350400616 0.931668147199618 1.0 0.996512857689306 152 Q15154,P42858,P14635,P09601,Q9BQS8,O14617,Q86U38,P62841,P11279,P62820,Q9BVK6,Q9Y6B6,Q14849,O75381,Q9UBN7,P43034,P49755,Q99584,Q96N67,Q96DB5,Q13315,O94901,Q00535,Q658Y4,Q96SN8,O14777,Q9BZD4,O94832,Q96D46,Q14674,Q9UBK9,O00203,Q15907,Q15363,P50570,Q9NR31 36 +Hematopoietic progenitor cell differentiation 0.2779360715736523 0.0842488799553166 0.9328585557133804 1.0 0.9976235075930904 29 Q9H2U1,Q9NUQ2,P78527,Q9NPH0 4 +Protein localization to nuclear envelope 0.3129012387434149 0.080805761784059 0.9355964258161382 1.0 1.0 7 Q8NFQ8,P61970 2 +Negative regulation of defense response 0.2752590714959012 0.0785939174072679 0.9373556257799768 1.0 1.0 34 O43657 1 +T cell migration 0.3127155424774576 0.0775930704031155 0.938151754780447 1.0 1.0 8 P05067 1 +Tissue remodeling 0.2892435027720618 0.0775017678521836 0.9382243849630104 1.0 1.0 20 O14773,Q9P2D1 2 +Regulation of hormone secretion 0.2767931891539025 0.07749442816549 0.9382302236259776 1.0 1.0 29 Q8N5M9,Q16836,Q9P2D1,Q8NE86 4 +Cochlea development 0.2783706887351068 0.0768654240487782 0.9387306037521904 1.0 1.0 4 P43034,P33993 2 +Histone h4 k16 acetylation 0.3130908136837906 0.0752331235817614 0.9400292302168264 1.0 1.0 11 O75844 1 +Thyroid gland development 0.2775831873905495 0.074883528161501 0.9403073823790014 1.0 1.0 4 P04049,Q02750,P28482 3 +Negative regulation of tor signaling 0.3120883532360584 0.0725417772436068 0.9421707595926716 1.0 1.0 10 P54646 1 +Positive regulation of dna binding 0.2922726552607987 0.0723337908310349 0.942336273923583 1.0 1.0 18 P09429,O60869,P09874,P07305,P0DP25,Q96HY6,Q8IXJ6 7 +Centrosome duplication 0.290018974453723 0.0710532233244761 0.943355396404384 1.0 1.0 19 P41208,Q96SN8 2 +Stress activated protein kinase signaling cascade 0.268884767073232 0.0699970508792093 0.9441960069392112 1.0 1.0 41 P05067,Q13546,P09429,P49327,Q9P035,Q96J02,Q99956,P78318,O75844,P43034,O75915 11 +T cell mediated immunity 0.3113065175861189 0.0697463424012918 0.9443955556636584 1.0 1.0 11 O15400,P09429,P01889,P36915,Q9NUQ9 5 +Regionalization 0.2751264344838218 0.0676985601828964 0.9460255954912868 1.0 1.0 28 Q5T9L3,Q8N2A8,Q13315,Q15363,O14965 5 +Hormone transport 0.2712368874474843 0.0664522879988468 0.9470177423589744 1.0 1.0 37 Q16836,Q8NE86,Q9P2D1,Q15907,Q8N5M9 5 +Neural precursor cell proliferation 0.2748266326049334 0.0659970310553254 0.947380189177708 1.0 1.0 29 Q15154,Q96N67,Q9UKA9,Q92974,O15031,Q8NCG7,O95456,P55209,Q9UBD5,P43034,Q8IXJ6 11 +Negative regulation of dna recombination 0.2923770778727372 0.065940915619441 0.9474248654982133 1.0 1.0 17 P07305,P16402,P10412,Q92522,P16403 5 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.2922269828249068 0.0653435649584144 0.9479004566182452 1.0 1.0 17 O95881,P46379,Q07812 3 +Positive regulation of endocytosis 0.2834540368501146 0.0648294190115153 0.9483098177295386 1.0 1.0 23 P50570,O75955,P50897 3 +Epidermis development 0.2672502040497038 0.0631145911993372 0.9496752553674784 1.0 1.0 49 Q13510,P51648,O00203,O75844,P43034,P16615,O95487,P42574 8 +Regulation of histone phosphorylation 0.3066636965428264 0.0613263869266149 0.9510992766190284 1.0 1.0 8 Q13315 1 +Negative regulation of phosphorylation 0.266896142373806 0.0594873335814432 0.9525639539487688 1.0 1.0 80 Q9H7B4,Q16625,P04062,O95684,Q86XL3,Q8TBX8,Q15363,P0DP25 8 +Negative regulation of apoptotic signaling pathway 0.2646872739233909 0.0580382352816504 0.9537181724914112 1.0 1.0 72 O95881,Q13546,P42858,Q92974,P45880,Q07820,P09601,P32119,O76024,P61289,Q9P0J0,Q07812,P05141 13 +Regulation of phagocytosis 0.2902314233180861 0.0574707824498388 0.9541701798557513 1.0 1.0 17 P50570,P09429,Q12907,Q8WTV0 4 +Somite development 0.3005677370595169 0.0569004247551904 0.9546245159571956 1.0 1.0 13 Q15363,Q13315,P78527 3 +Rna polymerase ii preinitiation complex assembly 0.3047576680682781 0.056382171889493 0.95503735913196 1.0 1.0 8 Q9Y6J9 1 +Negative regulation of binding 0.2678422338140518 0.0561636950991345 0.9552114026044888 1.0 1.0 39 Q6IAN0,P16615,O75381,Q07812,P09601,P35269,O14981,O14965 8 +Attachment of spindle microtubules to kinetochore 0.2805537553041615 0.0508487269972887 0.959446062541358 1.0 1.0 23 Q9H8V3,Q8NBT2,Q96DB5,P14635,Q15005,Q14457,O14777,Q9BZD4,Q8IXJ6 9 +Regulation of chemotaxis 0.2738872268503585 0.0490939614907358 0.960844415638864 1.0 1.0 27 P09429,Q13277,Q8NE86,Q13641,Q4KMQ2,Q9NUQ9 6 +Dendrite extension 0.3003213555360747 0.0490207277115458 0.960902777470861 1.0 1.0 7 Q9Y263,Q9BRT6,Q96PU5,Q96F07,Q7L576,O60271 6 +Protein k11 linked ubiquitination 0.3035196911597051 0.0481440068440951 0.96160147445753 1.0 1.0 10 Q9H1A4,Q9UJX4,Q9UJX3,Q16763,Q13042,P30260 6 +Purine nucleoside monophosphate biosynthetic process 0.2932803597184853 0.045348139599553 0.9638298170285472 1.0 1.0 14 P31939 1 +Regulation of nucleotide biosynthetic process 0.3014698792899563 0.0449717142003943 0.9641298549335148 1.0 1.0 9 P09874,P00403 2 +Telomere capping 0.288810674443974 0.0441384016351312 0.9647940825203968 1.0 1.0 15 Q15554,Q13315,P78527 3 +Nucleoside triphosphate metabolic process 0.2651051163764319 0.0421000559399769 0.9664189355782172 1.0 1.0 47 O75964,P56385,P04818,P00403,P24539,Q9UJZ1,Q9H773,P06576 8 +Central nervous system neuron differentiation 0.2803791785846632 0.0412652668153017 0.9670844225385786 1.0 1.0 21 P43034,O14949,Q00535 3 +Branching morphogenesis of an epithelial tube 0.2877839866153785 0.0405545724727947 0.9676510002532426 1.0 1.0 15 Q9UNS1,Q9Y5V3 2 +Negative regulation of cellular catabolic process 0.2662018940505787 0.0399505382521402 0.968132559539112 1.0 1.0 93 P09601,O15118,P30536,P10619 4 +Circadian rhythm 0.2645669192052026 0.0395203729304243 0.9684755109542644 1.0 1.0 48 P54646,P42345,P04818,P43490,Q03164,Q9UNS1,P54802,Q9Y5V3 8 +Positive regulation of telomere capping 0.2776642335766468 0.0387330806858926 0.969103198617128 1.0 1.0 5 Q14103,Q96GD4,Q96T60,P28482 4 +Leukotriene metabolic process 0.2603619381202645 0.0355595344959806 0.9716335746941775 1.0 1.0 4 Q99735,O14880,P09960 3 +Asymmetric cell division 0.2938293336899174 0.0340524500663184 0.9728353258232914 1.0 1.0 7 Q92974,Q96N67 2 +Organic acid metabolic process 0.2521982130460377 0.0338403194529529 0.9730044840708196 1.0 1.0 315 P54646,Q9BRR6,O60725,Q8N4Q0,P07099,P21796,P49915,P31939,P21912,Q13510,Q8TB61,Q9H7Z7,A8MXV4,Q06520,Q8NCG7,P00374,Q9HB40,P16435,P23786,O95470,Q9BXW6,A1L0T0,Q9NRN7,Q53GQ0,Q9NUJ1,P51648,Q13126,Q8NCC3,Q9NSD9,P05067,O15118,O14678,Q15067,Q15800,P78417,P49748,P52789,Q9H2D1 38 +Regulation of synapse assembly 0.2967986432540579 0.033158274899828 0.973548371617274 1.0 1.0 9 P05067 1 +Odontogenesis of dentin containing tooth 0.2947755950411826 0.0319036696089645 0.9745488722061322 1.0 1.0 8 Q07812 1 +Negative regulation of protein binding 0.2705357627475888 0.0312431368204428 0.9750756384836516 1.0 1.0 27 Q6IAN0,O75381,Q07812,P35269,P16615,O14965 6 +Regulation of cell differentiation 0.2533333330663432 0.0285739139267356 0.9772044172577748 1.0 1.0 231 Q13546,Q15154,P01889,P50750,P30536,Q8N4Q0,P17931,P51812,Q9H2U1,Q7L576,Q14444,Q15382,Q16706,Q9Y6C9,Q92974,P09874,O15031,Q9UGN5,Q9UBN7,P32119,P16435,P43034,O96005,O15360,Q96G23,Q8IXJ6,Q8WUJ1,Q96N67,P09429,O95628,P06493,Q99959,Q9P2D1,P55209,Q96SN8,Q15418,O14965,Q9UQB8,Q9NX40,P05067,P42345,Q92896,P78527,O00203,P50570,Q9NQC3 46 +Neural nucleus development 0.2795584400163819 0.0276562258641191 0.9779363370361114 1.0 1.0 19 P14854,P0DP25,P24539,O95487,Q8IXJ6 5 +Regulation of bone remodeling 0.2536485697606612 0.0223040253019106 0.9822054379555264 1.0 1.0 4 P21359,P02786,P41240 3 +Regulation of bone resorption 0.2536485697606612 0.0223040253019106 0.9822054379555264 1.0 1.0 4 P21359,P02786,P41240 3 +Cytoplasmic pattern recognition receptor signaling pathway 0.2759533279399809 0.0202979346116265 0.9838057033897972 1.0 1.0 20 O43657,Q9NUD5 2 +Ribosomal small subunit export from nucleus 0.2893377929142773 0.0195743422700684 0.9843829318138452 1.0 1.0 8 P62841 1 +Endosomal transport 0.2637307533154097 0.0187336376512537 0.9850535939936568 1.0 1.0 84 O95249,Q4KMP7,O15260,Q9BVK6,Q9Y5X3,Q13190,Q2M389,Q15904,Q9Y5X2,Q15907,P53367,O00203,O75503,Q8NBN3,Q15057,Q9H223 16 +Mitotic g1 s transition checkpoint signaling 0.2920428052725259 0.0183604319932851 0.9853513178126424 1.0 1.0 10 Q13315 1 +Positive regulation of immune effector process 0.2628485413292641 0.0162444708705775 0.9870393575116392 1.0 1.0 38 P01889,P09601,Q9H2U1,Q9NUQ9,Q99623,P11279,Q96FZ2 7 +Regulation of dephosphorylation 0.263843399218063 0.0135997973909731 0.9891492661147168 1.0 1.0 36 P42345,P42858,P04062,Q86XL3,P0DP25,Q96GX5 6 +Pyrimidine deoxyribonucleotide biosynthetic process 0.2645255474452609 0.012811796799371 0.9897779447834016 1.0 1.0 5 P33316,P04818,P34896,P32321 4 +Negative regulation of molecular function 0.2527623544767504 0.012143799806407 0.9903108877708282 1.0 1.0 234 Q6IAN0,Q15392,Q96GX5,Q14012,O95684,P06280,P46934,P09601,P51812,P17931,P42574,P62841,Q15043,Q15041,O75381,Q9UBN7,P0DP25,P32119,P16435,P49755,Q6YHU6,P04062,O76024,Q9H1E3,Q96SN8,Q92530,Q15554,Q01105,Q15418,O14965,Q9H7B4,O75190,P05067,P16615,P78417,Q96J02,Q99523,Q8TBX8,Q15363,P27544,P35269,Q07812,Q99623,O14981,Q15070 45 +Protein peptidyl prolyl isomerization 0.271037191949517 0.0117328213159335 0.9906387777940816 1.0 1.0 24 Q9NWM8,O95302,Q9Y680 3 +Glial cell differentiation 0.2602769018392906 0.0090965725609774 0.9927420852933876 1.0 1.0 41 P05067,Q15382,P42345,P04062,P06493,P49770,Q8IXJ6 7 +Negative regulation of vascular endothelial growth factor receptor signaling pathway 0.2624361923960453 0.0090694482560173 0.9927637264648086 1.0 1.0 5 P46934 1 +Regulation of muscle organ development 0.2858895649772727 0.0076708969831999 0.9938795697533876 1.0 1.0 9 O75955,Q9NQ29 2 +Histone h2a ubiquitination 0.283459964932791 0.0070461975910487 0.9943779942508416 1.0 1.0 8 Q8IWV8,P63208,O95071,Q16531,Q96FW1,Q13620,Q99496 7 +Fat cell differentiation 0.2639694875856377 0.0066570992599605 0.9946884425127972 1.0 1.0 28 Q6IAN0,Q9BRK5,Q9UBN7,Q8N4Q0,Q9NZ08,Q8IXJ6 6 +Regulation of protein binding 0.2592652698674521 0.0057584312947045 0.9954054619676462 1.0 1.0 55 Q6IAN0,O75955,P05067,Q96D46,P14735,O75381,Q00535,Q07812,P35269,Q9BUN8,P16615,O14965 12 +Negative regulation of lymphocyte activation 0.2748236551161579 0.0044933305062219 0.996414853026536 1.0 1.0 18 P09429,Q13315,P32119,P17931,P42574 5 +Platelet morphogenesis 0.2790951804417911 0.0037233223859398 0.9970292254174072 1.0 1.0 7 P78527 1 +Sphingomyelin metabolic process 0.2757009345794524 0.0035120534610994 0.9971977925273228 1.0 1.0 6 Q9NXE4,O15269,O15270,P22059,Q9P0L0 5 +Hemostasis 0.264859927120167 0.0021210083929742 0.9983076814187783 1.0 1.0 27 P52429,O00203,P38435,P32119,Q9BWH2 5 +Regulation of immune response 0.2537983909375608 0.0001781886201779 0.9998578260518016 1.0 1.0 129 P01889,Q96FZ2,P09601,P17931,P51812,P11279,O75955,Q9NUD5,O43657,P49770,Q9NUQ9,Q9NPR9,P09429,P78527,O00203,Q07812,Q9UJZ1,Q99623,P46379,Q9NZ08,Q9NQC3 21 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0eea3e18a9d450a93dd0301b1fec678d505bfb11 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of janus kinase activity", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activation of store operated calcium channel activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Acylglycerol transport", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult heart development", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine catabolic process", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in coronary vascular morphogenesis", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antifungal innate immune response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide antigen via mhc class ib", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in blood vessel morphogenesis", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Atrioventricular node development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome lysosome fusion", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Av node cell to bundle of his cell communication", "Av node cell to bundle of his cell signaling", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone mineralization involved in bone maturation", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "Bundle of his cell to purkinje myocyte signaling", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein deglutamylation", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into cytosol", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate import across plasma membrane", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac right ventricle morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine secretion", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell differentiation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hydroperoxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nicotine", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorio allantoic fusion", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalamin transport", "Cochlea development", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common bile duct development", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion transport", "Copulation", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial nerve morphogenesis", "Cranial nerve structural organization", "Cranial skeletal system development", "Craniofacial suture morphogenesis", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide biosynthetic process", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytidine to uridine editing", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Dehydroascorbic acid transport", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of calcium ion", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of light stimulus involved in sensory perception", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of stimulus involved in sensory perception", "Detection of stimulus involved in sensory perception of pain", "Detection of temperature stimulus", "Detection of temperature stimulus involved in sensory perception", "Detection of temperature stimulus involved in sensory perception of pain", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Dichotomous subdivision of an epithelial terminal unit", "Dichotomous subdivision of terminal units involved in salivary gland branching", "Diencephalon development", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine secretion", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal cell differentiation", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardium development", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of left right asymmetry", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facial nerve morphogenesis", "Facial nerve structural organization", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain neuron fate commitment", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled glutamate receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactolipid biosynthetic process", "Galactolipid metabolic process", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Gamma delta t cell activation", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastric acid secretion", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular basement membrane development", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glomerulus morphogenesis", "Glomerulus vasculature morphogenesis", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import across plasma membrane", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gonadotropin secretion", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Heat generation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus cell migration", "Hypothalamus development", "Hypothalamus gonadotrophin releasing hormone neuron differentiation", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid catabolic process", "Icosanoid metabolic process", "Icosanoid transport", "Immature b cell differentiation", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Inhibitory postsynaptic potential", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate biosynthetic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Inositol trisphosphate biosynthetic process", "Inositol trisphosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphocyte migration into lymphoid organs", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage activation involved in immune response", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of animal organ identity", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Marginal zone b cell differentiation", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature b cell differentiation", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane fusion involved in viral entry into host cell", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microtubule severing", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Midgut development", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotactic protein 1 production", "Monocyte chemotaxis", "Monocyte differentiation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Motor neuron migration", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multinuclear osteoclast differentiation", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myd88 independent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid dendritic cell differentiation", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myoblast proliferation", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Nail development", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immune response to tumor cell", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of atpase coupled calcium transmembrane transporter activity", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axon extension involved in axon guidance", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone mineralization", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of catecholamine secretion", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cell adhesion mediated by cadherin", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell proliferation involved in kidney development", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular extravasation", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular response to vascular endothelial growth factor stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromatin organization", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of digestive system process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of dopamine secretion", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell apoptotic process", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of g0 to g1 transition", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of granulocyte differentiation", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of high voltage gated calcium channel activity", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrogen peroxide metabolic process", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon beta production", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 1 beta production", "Negative regulation of interleukin 1 production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein metabolic process", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage derived foam cell differentiation", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotactic protein 1 production", "Negative regulation of monocyte chemotaxis", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell activation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil activation", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of nlrp3 inflammasome complex assembly", "Negative regulation of non canonical wnt signaling pathway", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of ossification", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl cysteine s nitrosylation", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to microtubule", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of ribosome biogenesis", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of torc1 signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tubulin deacetylation", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest cell migration involved in autonomic nervous system development", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron neuron synaptic transmission", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nitrogen utilization", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling involved in heart development", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Olfactory nerve development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Opsonization", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast development", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Osteoclast fusion", "Otic vesicle development", "Otic vesicle formation", "Otic vesicle morphogenesis", "Otolith development", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Outflow tract septum morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parasympathetic nervous system development", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide modification", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericardium development", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine acyl chain remodeling", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet dense granule organization", "Platelet derived growth factor receptor alpha signaling pathway", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic dna fragmentation", "Positive regulation of apoptotic process involved in development", "Positive regulation of apoptotic process involved in morphogenesis", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagosome maturation", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axon extension involved in axon guidance", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell differentiation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of b cell receptor signaling pathway", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood pressure by epinephrine norepinephrine", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell differentiation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cd8 positive alpha beta t cell differentiation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell growth involved in cardiac muscle cell development", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular ph reduction", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental pigmentation", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna catabolic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of heat generation", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide mediated programmed cell death", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of inhibitory postsynaptic potential", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 23 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic cell cycle phase transition", "Positive regulation of meiotic nuclear division", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myoblast proliferation", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immune response to tumor cell", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of opsonization", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of osteoblast proliferation", "Positive regulation of osteoclast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of peroxisome proliferator activated receptor signaling pathway", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet derived growth factor receptor signaling pathway", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein localization to synapse", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle fiber development", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of store operated calcium channel activity", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride catabolic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of uterine smooth muscle contraction", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor receptor signaling pathway", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic animal morphogenesis", "Post embryonic animal organ development", "Post embryonic animal organ morphogenesis", "Post embryonic camera type eye development", "Post embryonic development", "Post embryonic eye morphogenesis", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Prepulse inhibition", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein deglutamylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked deubiquitination", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c activating g protein coupled receptor signaling pathway", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to site of double strand break", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein side chain deglutamylation", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antifungal innate immune response", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagic cell death", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of blood vessel remodeling", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone mineralization involved in bone maturation", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching involved in ureteric bud morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell differentiation", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cd8 positive alpha beta t cell differentiation", "Regulation of cdc42 protein signal transduction", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell proliferation involved in kidney development", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular ph reduction", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centromere complex assembly", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte development", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to fungus", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gamma aminobutyric acid secretion", "Regulation of gastric acid secretion", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glutamine family amino acid metabolic process", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of heat generation", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homophilic cell adhesion", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipid transporter activity", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage derived foam cell differentiation", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myoblast proliferation", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immune response to tumor cell", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil activation", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil degranulation", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide mediated signal transduction", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non canonical wnt signaling pathway", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of opsonization", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast development", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pancreatic juice secretion", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl cysteine s nitrosylation", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phosphatidylinositol dephosphorylation", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic cytosolic calcium ion concentration", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor activity", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of cardiac muscle", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of sarcomere organization", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sensory perception", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle cell proliferation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of store operated calcium channel activity", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by norepinephrine epinephrine", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride catabolic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of voltage gated sodium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal system vasculature development", "Renal system vasculature morphogenesis", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Resolution of recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to camptothecin", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cycloheximide", "Response to cytokine", "Response to dexamethasone", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 17", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to pheromone", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to staurosporine", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to vitamin k", "Response to water", "Response to water deprivation", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to yeast", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell programmed cell death", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 3 uridylation", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secondary palate development", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Semicircular canal development", "Semicircular canal morphogenesis", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of chemical stimulus", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory perception of taste", "Sensory perception of temperature stimulus", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfation", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taurine transport", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thioester biosynthetic process", "Thioester metabolic process", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 2 signaling pathway", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Trigeminal ganglion development", "Trigeminal nerve development", "Trigeminal nerve morphogenesis", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type b pancreatic cell proliferation", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Ureter development", "Urinary bladder smooth muscle contraction", "Urinary tract smooth muscle contraction", "Urogenital system development", "Uronic acid metabolic process", "Uterine smooth muscle contraction", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Vagina development", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated cholesterol transport", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Vestibulocochlear nerve development", "Vestibulocochlear nerve morphogenesis", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAGAB", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEH", "APEX1", "API5", "APIP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARL8B", "ARMC1", "ARMC10", "ARMC6", "ARMC8", "ARMC9", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "AS3MT", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATR", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT1", "BCAT2", "BCCIP", "BCKDHB", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BECN1", "BEND3", "BICD2", "BIRC6", "BLM", "BLMH", "BLOC1S1", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C19orf70", "C1QBP", "C21orf59", "C2CD2L", "C2CD5", "C2orf49", "C3orf58", "C5orf51", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPF", "CENPU", "CENPV", "CEP250", "CEP290", "CEP44", "CEP55", "CEP97", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTF8", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT4", "CNOT7", "CNP", "CNPY2", "COA3", "COASY", "COG5", "COG7", "COG8", "COIL", "COLGALT1", "COMMD7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF15", "DCAF16", "DCAF7", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENND5B", "DENR", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSE", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFR3A", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "ENSA", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM105A", "FAM120B", "FAM126A", "FAM129B", "FAM162A", "FAM208A", "FAM20B", "FAM213A", "FAM49B", "FAM50A", "FAM83D", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXL18", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN6", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHITM", "GID8", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR180", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTSE1", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK1", "HP1BP3", "HPF1", "HPRT1", "HPS5", "HS1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS4", "INTS6", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRS4", "ISCA2", "ISG20L2", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA1211", "KIAA1468", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT4", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC14", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCRS1", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL13", "METTL25", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOCS2", "MOCS3", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDZ", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL19", "MRPL2", "MRPL20", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS27", "MRPS30", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NET1", "NEU1", "NF1", "NFATC2IP", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OTULIN", "OXA1L", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAWR", "PAXBP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCNT", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEBP1", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF6", "PHGDH", "PHIP", "PHLDB2", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLEKHA7", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "POMP", "PON2", "POP1", "POR", "POU2F1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPFIBP1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REL", "RELA", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SACS", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SC5D", "SCAF1", "SCAF11", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SH3RF1", "SHCBP1", "SHMT1", "SHMT2", "SHPRH", "SHTN1", "SIGMAR1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SLU7", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SMYD4", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRA1", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR3", "SSRP1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TENM3", "TERF2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TM7SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM199", "TMEM201", "TMEM214", "TMEM33", "TMEM43", "TMEM87A", "TMEM97", "TMLHE", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC28", "TTC37", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL4A", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBL7", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS28", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VPS72", "VRK1", "VRK2", "VRK3", "WAPL", "WARS", "WASF2", "WASHC3", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR35", 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"AIFM1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH3A2", "ALG1", "ALG11", "ALKBH5", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANKRD13A", "ANKRD17", "ANO6", "ANXA3", "AP1G1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APOL2", "APOO", "APOOL", "APP", "ARCN1", "ARF4", "ARFGAP3", "ARFIP1", "ARHGEF2", "ARL6IP1", "ARL6IP5", "ARMC1", "ARRB2", "ARSA", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ATAD1", "ATAD3A", "ATAD5", "ATG9A", "ATIC", "ATL2", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATR", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BAX", "BCAP31", "BCAS3", "BCCIP", "BCKDK", "BCL2L13", "BCR", "BECN1", "BICD2", "BLMH", "BLOC1S1", "BRAT1", "BSG", "BTAF1", "BUB1", "BUB1B", "C12orf73", "C19orf70", "C1QBP", "CAD", "CALM3", "CAMK1", "CAMK2D", "CANX", "CAPRIN1", "CARM1", "CASK", "CASP3", "CC2D1A", "CCAR2", "CCDC47", "CCNB1", "CCNB2", "CCT2", "CD109", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC6", "CDK1", "CDK4", "CDK5", "CDK5RAP2", "CDK9", "CERS1", "CERS2", "CETN2", "CHD1L", "CHD7", "CHD8", "CHEK2", "CHORDC1", "CHTF18", "CHTF8", "CISD1", "CLASP1", "CLASP2", "CLCN7", "CLN5", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLSTN3", "CLTC", "CLUH", "CNNM3", "CNNM4", "CNOT4", "COA3", "COG5", "COMT", "COPA", "COPE", "COPG1", "COPS3", "COPS5", "COPS8", "CORO1B", "COX15", "COX2", "COX4I1", "COX6B1", "COX7A2", "CPT2", "CPVL", "CRK", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CTSA", "CUL4B", "CXorf56", "CYB5B", "CYB5D2", "CYFIP1", "CYFIP2", "CYP51A1", "DAGLB", "DCAKD", "DCPS", "DCTD", "DCTN1", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DDB1", "DDRGK1", "DDX10", "DERA", "DERL1", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX29", "DHX36", "DIAPH2", "DICER1", "DIEXF", "DKC1", "DNAAF5", "DNAJB1", "DNAJB6", "DNAJC1", "DNAJC13", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOLPP1", "DPYSL5", "DSE", "DUSP12", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC2H1", "ECE1", "ECSIT", "ECT2", "EDF1", "EEF1D", "EFR3A", "EHD4", "EIF2B2", "EIF3E", "EIF4A3", "EIF4B", "EIF4E", "EIF5", "EIF5A", "EIF5B", "ELP3", "EMC7", "EMD", "ENSA", "EPB41L3", "EPDR1", "EPHX1", "EPPK1", "EPRS", "ERAP1", "ERCC2", "ERCC6L", "ERGIC3", "ESPL1", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC7", "EZR", "FABP5", "FADS2", "FAM120B", "FAM126A", "FAM162A", "FAM49B", "FAM50A", "FAM8A1", "FAM91A1", "FANCA", "FAR1", "FARP2", "FARSB", "FASN", "FCGRT", "FDFT1", "FECH", "FERMT2", "FGFR1OP", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FKRP", "FLOT1", "FMR1", "FNTA", "FNTB", "FOXRED1", "FRYL", "FUCA2", "FUNDC2", "FYCO1", "GAA", "GALNT1", "GALNT4", "GBA", "GBF1", "GCN1", "GDAP1", "GET4", "GGCX", "GGH", "GINS1", "GINS2", "GINS4", "GLA", "GLB1", "GLG1", "GM2A", "GMPPB", "GMPS", "GNL1", "GNPAT", "GOLGA5", "GOLGB1", "GOLPH3", "GOSR1", "GPAA1", "GPD1L", "GPD2", "GPR107", "GPR108", "GPX8", "GSTA4", "GSTO1", "GSTZ1", "GTF2F1", "H1F0", "H1FX", "H2AFY", "H3-3A*", 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"MRPL10", "MRPL58", "MSH2", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTOR", "MTX1", "MYCBP2", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO6", "NAA15", "NAA35", "NAA40", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NASP", "NBAS", "NCAPD3", "NCKIPSD", "NCLN", "NCSTN", "ND1", "NDC1", "NDC80", "NDUFA11", "NDUFA13", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB3", "NDUFB9", "NEDD4", "NEDD4L", "NELFCD", "NENF", "NET1", "NF1", "NMD3", "NNT", "NOB1", "NOP9", "NPC1", "NPEPPS", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NUCB2", "NUCKS1", "NUDT16", "NUDT19", "NUDT5", "NUDT9", "NUF2", "NUTF2", "OCIAD1", "OCLN", "OCRL", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL8", "OTUB1", "OXA1L", "OXSM", "PABPC1", "PAFAH1B1", "PAIP1", "PAK2", "PARP1", "PARP2", "PCID2", "PCM1", "PCNP", "PCNT", "PCYOX1", "PDCD4", "PDCD5", "PDK3", "PDSS1", "PEX14", "PFDN5", "PFDN6", "PGM2", "PGRMC1", "PGRMC2", "PHB2", "PI4K2A", "PIBF1", "PIGK", "PIGU", "PIK3C2A", "PIP4K2C", 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0.3438986948818692 0.0264151659552541 0.3228460923172884 0.0069551143734033 0.000626517772181 1.815017509270564e-07 +Respirasome 15 45 2.980173908690144 0.0028808477926611 15.08495145631068 43.37378640776699 1.2524823540042158 0.2922262294299136 6.290312072426717 4.489587979561489 1.7783434517583476 0.3462844006183536 0.0318748387409637 0.0650462755169659 0.00132313066272 8.587907478336206e-07 1.7725163111437326e-08 +Cis golgi network 6 16 2.9479688302104803 0.0031986931486445 5.446601941747573 14.91747572815534 1.304763677188147 0.2415633778835601 2.9087352716231463 3.2280604409731746 1.23405443481851 0.2890539664507128 0.0002703275031585 0.0155575631698287 0.000509979222831 0.0142235096743441 0.0024763006502838 +Golgi associated vesicle membrane 5 22 2.908385275070027 0.0036330044915062 4.201456310679611 19.589805825242717 0.79417597045559 0.3511132904952779 2.457541951272857 2.384047500904294 1.2111660039755976 0.3110721945776767 0.0041367574832764 0.0163255968864409 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0.0008717411361388 9.22092773458021e-05 0.0002808101441202 +Vacuolar membrane 40 123 2.7514737995575653 0.0059327765476695 31.91504854368932 121.20631067961163 0.8693310080509177 0.3422944242486927 10.598363436017626 13.850227259030053 1.9844114292962869 0.3837860427998523 0.0196543981557686 0.0824567482863823 0.0156550103902373 0.0001977141065674 1.802171476305432e-05 +Intrinsic component of mitochondrial inner membrane 15 30 2.748408292513808 0.0059885384902129 13.946601941747574 31.446601941747577 1.7062420859184484 0.2149692261988765 6.992163651608136 3.3601842163433866 1.8185871159494191 0.3070405082296492 0.0077423266250305 0.2183837422916212 0.0013172485850202 0.0012377122057681 3.5073165494242945e-06 +Golgi cisterna 9 24 2.7321169210320697 0.0062928804507635 8.524271844660195 22.490291262135923 0.9086972174309816 0.318868202549777 4.2525712614684625 5.269200019661922 1.391079392561209 0.3149122340418913 0.4505349580539141 0.3024216363859021 0.5071521873221705 0.0317341418138132 0.0027070136406106 +Cytochrome complex 7 18 2.714750105146193 0.0066325797353212 6.021844660194175 16.08495145631068 1.0267019648816196 0.2321293206617183 2.9315837025395948 1.6175814223208935 1.624269406530766 0.2919563386676546 0.0230572634873926 0.1330370821365251 0.0026246094830452 4.450565670464667e-06 6.032921662821078e-06 +Transport vesicle 37 91 2.706517535202956 0.0067992991468939 26.046116504854368 92.34708737864078 0.9512017428916244 0.4458616213657612 9.46815354334768 9.09007867686459 1.424803887648301 0.3967491654773343 0.1631407547178678 0.3675531568855632 0.2423406323390604 0.2989758563376967 0.008651591599046 +Azurophil granule 23 70 2.6277357303708744 0.0085955263352812 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 0.0671474226148655 0.1090224971962506 0.0987427785556486 0.0018745467202956 6.062412727623742e-07 +Vesicle membrane 68 273 2.6243402327783265 0.0086817012682871 59.03398058252427 252.66747572815535 0.5350285241159404 0.6113983912197217 17.512237349079548 29.567983380691818 1.3292572988488431 0.402876017449685 0.0465868975235878 0.0796227953740581 0.0643053502208768 0.0194455413836578 0.0024060278672291 +Golgi cisterna membrane 7 18 2.569638394144224 0.0101804719135689 6.233009708737864 17.101941747572816 0.7930989258143627 0.3092897028410761 3.2184356191878685 3.952300069740005 1.3504727992091758 0.2953094162507478 0.3469532683251365 0.2260688267312995 0.3955810682553247 0.0082403851981354 0.0034128621981353 +Golgi lumen 2 5 2.558333110302132 0.0105175290142063 1.745679012345679 4.548148148148148 1.1368717941323 0.2457507117503182 1.2159484823715767 1.4039724163790972 1.161880305109492 0.2643265801751675 0.230458544012733 0.1457663642848915 0.266209970857853 0.0415700360883472 0.2031992995383869 +Tim23 mitochondrial import inner membrane translocase complex 3 6 2.547085143571357 0.0108626925906702 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 0.0034334205639732 0.0526645480715484 0.0047533286028597 9.701143498590324e-05 0.0013990642028563 +Secretory granule membrane 25 72 2.537658301170275 0.0111596884994786 19.699029126213592 69.8495145631068 0.9295860214656708 0.3887665887416008 7.284889203542463 7.49087955205396 1.5950364553562375 0.3903287060113383 0.182766124350531 0.2224854546727621 0.2522992371519743 0.0126405625937654 0.0031512494634226 +Nucleotide excision repair complex 1 5 2.520306715981872 0.0117252614090661 1.5533980582524272 4.934466019417476 0.2841448149228163 0.5542842134362547 1.31811983882756 0.9100711891020776 0.8468277475661165 0.3060785085592118 0.0860283086388496 1.0 0.1008375048293403 0.027832231049335 0.0974859568290139 +Respiratory chain complex iii 3 8 2.4743152201113925 0.0133491855709386 2.5145631067961167 7.186893203883495 0.8648567981956616 0.2640480169416735 1.5224155414895728 0.9433070612984726 1.3007640218760226 0.2795290338624424 0.100864684735291 1.0 0.0066572828402184 0.0002022933287296 0.0028040242445346 +Golgi associated vesicle 7 33 2.4591904145989893 0.0139250739218419 6.745145631067961 30.33009708737864 0.696501539533066 0.3869218626415568 3.3093865809086713 3.3403631844705557 1.2881306559419168 0.3350067162782171 0.0178361082707862 0.0437266531990119 0.0275216398495969 0.0012385676091947 0.0054856561315088 +Intrinsic component of plasma membrane 27 78 2.446048665507451 0.0144431503771713 29.711165048543688 79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.8991876460858538 0.9046312933555888 0.8330259814094686 0.3431228375054138 0.3418261238102543 +Golgi stack 14 34 2.393439885879989 0.0166912162541916 9.67233009708738 31.25242718446602 0.7055900861920908 0.4265468940333196 4.557817503574521 5.847941213698429 1.2226912303929196 0.3463938041520717 0.5528580736305715 0.3837329617083285 0.6136637824136402 0.089202410661812 0.0207966076304104 +Coated vesicle membrane 9 60 2.340917070837512 0.0192364394106556 12.470873786407768 56.310679611650485 0.4487003631021872 0.5093312281655428 5.273732877175169 4.573093801439982 1.1487677393522833 0.3682374685669872 0.015540504727495 0.0199622774755299 0.0267992171546872 0.066807830876721 0.0287949721551627 +Microbody membrane 10 26 2.2461051442950786 0.0246972739270565 9.83980582524272 26.8373786407767 1.0322166739723002 0.3740701224912098 5.101262737371427 4.075770333088885 1.3138416014090577 0.3534887732287703 0.373241446469727 1.0 0.4242240140575919 0.1596086760652474 0.0060616304531859 +Mitochondrion 115 641 2.202485841642571 0.0276310081560624 150.5606796116505 610.75 0.3893280889581553 0.5444893646695418 55.48150839960472 53.47985851692477 2.1394883185001157 0.4272675793576402 3.643525332799317e-05 0.0001225187498266 4.2258120010577046e-07 1.0809277920082355e-10 1.9881762791029e-15 +Intrinsic component of synaptic vesicle membrane 4 7 2.1720947470455525 0.0298485171194464 3.648058252427184 9.116504854368932 0.724313202500786 0.4129003553732678 2.1933086936710184 1.7154408466980504 1.018214829869002 0.3297596143558817 1.0 1.0 1.0 1.0 0.1423023069394473 +Coated vesicle 19 90 2.163956098053162 0.0304677189119928 21.15776699029126 89.28398058252426 0.7996411773181966 0.4463095457932411 7.252509633536616 8.542551157088123 1.3406722753228342 0.3892656029628454 0.0058418554307936 0.0166552464814746 0.012797337283199 0.0244236045811103 0.0092983401263268 +Respiratory chain complex iv 5 11 2.161481616160703 0.0306581555394231 3.754854368932039 9.74271844660194 0.8119042784517004 0.2590637228606872 2.032646352020888 1.0643473720992946 1.3870085883810457 0.2875864020654643 0.1369226886862704 0.0847528009868792 0.1596960736798767 5.302129833761715e-05 0.0001461959825676 +Mitochondrial permeability transition pore complex 3 5 2.1544417963029003 0.031205541799596 1.325242718446602 4.330097087378641 0.7242621093920801 0.3068172423227327 1.3075745312141824 0.4753812882464113 1.1252583476072917 0.2626584709430976 0.0478709038219733 0.0290719737908623 0.0563150378970086 0.0082211090226218 7.736530612306859e-05 +Intrinsic component of golgi membrane 6 7 2.128747323387386 0.033275171240015 4.655339805825243 10.08495145631068 1.3178763872097854 0.2129685736028588 2.6046347098798024 1.9780511021437377 1.2704958978874823 0.2699640456705705 0.0456983473100118 0.1868885334554594 0.0614247268920475 0.0808776862517318 0.3363841302805421 +Copii coated er to golgi transport vesicle 12 29 2.121106015155052 0.033912881872862 10.810679611650484 32.4247572815534 0.9209697551014924 0.3949407296339237 5.01338814607213 3.9617918728777735 1.2509556054930144 0.3456813773327062 0.4227209904197462 1.0 0.4775398588675821 0.0789974698724344 0.0014020336345134 +Proteasome core complex beta subunit complex 4 7 2.0940385038718063 0.0362565504255025 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 0.0709501192712976 1.0 0.0832836732680532 0.0188064524051028 0.0077568745967145 +Pore complex 5 10 2.087215101712662 0.0368686949763705 3.2111650485436893 8.830097087378642 1.029129610796519 0.2182996080526768 1.893158762220583 0.772882004264421 1.343874754683687 0.2717215815078918 0.0082254277129148 0.0030581061915538 0.0113213926532688 0.0074273483269255 0.0001016217979366 +Phagocytic vesicle membrane 8 23 2.051990369331484 0.0401705983767219 7.512135922330097 23.83009708737864 0.5348434256443761 0.4468744105904624 3.681144332021715 3.0024693704800938 1.1652764437248655 0.3385441964418395 0.3935168848661239 1.0 0.1163398228410075 0.0034676048515423 0.0091218528537202 +Azurophil granule membrane 10 22 2.036087505394449 0.0417415691607812 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 0.0538078303441176 0.2027885470531376 0.0720571885403784 0.0048857385669874 0.0003165443223373 +Postsynaptic density membrane 1 8 1.9962328135831628 0.0459085873025308 1.8106796116504855 6.669902912621359 0.9700827983290172 0.2992953748741365 1.3610684424812354 1.822930264123012 0.935271302642404 0.2569047527325972 0.2491592407033175 0.1583124314184509 0.2872333566147377 0.2076979954646016 0.5144612633618493 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f262856f5ae00b23f3c51baede68591b71ccfc63 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 909, + "title": "Average number of proteins per term", + "value": 30.231023102310232 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a6d20cc6e23477b0960bde071dcc11367f05ad8c --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..aba8bb418fdcc02346aabdb6b75879da99b47e1d --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,289 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Organelle subcompartment 0.5538051746943864 6.536856817946362 6.282514067830412e-11 5.710805215670748e-08 5.710805378557844e-08 380 Q6IAN0,P30519,Q15392,P24390,P01889,Q9P035,Q9BQE5,P09601,P07099,Q6NTF9,Q14108,O00461,Q99720,Q8NAT1,Q5VYK3,P43307,Q5BJF2,Q8N511,P67812,Q16706,Q9UM00,Q9UL01,Q8TB61,O95197,Q14849,Q96GC9,Q8NF37,Q9NPR9,O43731,O95487,Q96G23,Q6YHU6,O95470,P04062,Q86UE4,P51648,O75844,Q9Y282,Q03518,Q06136,Q15629,Q15800,Q9P2W9,P37268,Q9NQC3,Q9Y3B3,Q9HD20,Q9BRR6,Q86XL3,O60725,Q16850,P38435,Q8N0U8,P52292,O15127,O76062,O43292,Q9Y5M8,P48449,Q86YN1,Q5T9L3,Q8NFQ8,Q03519,A1L0T0,Q53GQ0,Q96KC8,P53367,Q8N5M9,Q8NBN3,Q9UBU6,Q9BUN8,O00264,Q96PC5,P05067,O14678,O60512,Q96L58,Q9NUQ2,Q15363,P27544,P16615,Q07065,O95249,Q9Y4P3,Q9H4A6,Q14534,Q8IV08,Q8TCT9,Q9BUR5,Q96HY6,Q8TBA6,Q15382,Q96RL7,Q9Y6B6,Q13190,P16435,Q14739,P49755,Q96A33,Q10472,O15260,Q658Y4,P42345,Q07812,Q9BT22,Q6NUM9,Q9NZ08,P51571,P35613,O95864,Q2TAA5,Q8NHH9,Q9H3N1,Q15041,Q9BVK6,Q15904,Q9UBM7,P48651,Q96N66,Q6UX53,O15269,Q969V3,Q7Z3C6,O76024,Q9BTU6,O75845,P57088,Q12907,P50570,O00767,Q9NPA0 131 +Endoplasmic reticulum 0.5237310607058961 6.3524476015768 2.1191562264243336e-10 1.926312833579747e-07 9.631565094548597e-08 488 P80303,P30519,Q15392,Q6IAN0,P24390,P01889,Q9P035,P30536,Q9BQE5,Q13641,P09601,P07099,Q6NTF9,Q14108,Q99720,Q8NAT1,Q5VYK3,P43307,Q5BJF2,Q8N511,P67812,Q02818,Q9UM00,Q9UL01,Q8TB61,O95197,Q14849,O76094,Q96GC9,Q8NF37,O43731,O95487,Q96G23,Q6YHU6,O95470,Q92643,P27635,P04062,Q86UE4,P06493,P51648,O75844,Q9Y282,Q03518,Q06136,Q8TED1,Q15629,Q92530,Q9UQB8,Q9Y680,O15118,O94832,Q15800,P46977,P50402,Q9P2W9,P50851,Q02878,Q99523,Q8TBX8,P10619,O75503,O15173,Q9Y394,P37268,O60476,Q9NQC3,Q9Y3B3,Q8IY95,Q6NUQ1,Q9HD20,Q9BRR6,Q86XL3,O60725,P46778,P26373,Q16850,P38435,P13674,O95302,Q9BU23,Q8N0U8,Q9NZ01,P52292,Q9BRK5,Q13510,P62820,O76062,Q9HCU5,O95456,O43292,Q15005,Q9Y5M8,P48449,Q86YN1,O14975,P04439,P14859,Q92542,Q5T9L3,Q8NFQ8,Q96AG4,Q03519,Q15631,A1L0T0,Q53GQ0,Q15042,O43865,Q96KC8,O00584,Q8N5M9,P27824,Q9UBU6,Q9BUN8,O00264,Q96PC5,P05067,O14678,Q14257,Q9NUQ2,P52789,P62847,Q15363,P27544,Q9NR31,P16615,Q96LJ7,Q07065,P42858,Q9Y4P3,Q14534,Q8IV08,Q8TCT9,Q9BUR5,Q96HY6,P55327,Q15382,Q96RL7,Q9Y6B6,Q13190,Q9H223,P16435,Q14739,P49755,Q96A33,Q9NWM8,Q10472,O15260,Q9UMX5,O95881,P42345,Q9BTY2,Q96AY3,Q07812,Q9BT22,Q99797,Q6NUM9,Q9NZ08,P51571,P35613,P15289,O95864,Q9H9S5,Q2TAA5,Q8NHH9,Q9H3N1,Q15041,Q9BVK6,Q15904,Q9UBM7,P48651,O43681,P83731,Q96N66,Q6UX53,O15269,Q969V3,Q7Z3C6,P62266,O76024,Q6ZXV5,Q01105,O75845,P57088,Q12907,O00767,P29692,Q9NPA0,Q9H6S0,Q9BTV4 190 +Nuclear outer membrane endoplasmic reticulum membrane network 0.5728907544304138 5.873080857635064 4.277696940833311e-09 3.888418968522599e-06 1.2961421733754928e-06 314 Q6IAN0,P30519,Q15392,P24390,P01889,Q9P035,Q9BQE5,P09601,P07099,Q6NTF9,Q14108,Q99720,Q8NAT1,P43307,Q5BJF2,Q8N511,P67812,Q9UM00,Q9UL01,Q8TB61,O95197,Q14849,Q96GC9,Q8NF37,O43731,O95487,Q96G23,Q6YHU6,O95470,Q86UE4,P51648,O75844,Q9Y282,Q03518,Q06136,Q15629,Q15800,Q9P2W9,P37268,Q9NQC3,Q9Y3B3,Q9HD20,Q9BRR6,Q86XL3,O60725,Q16850,P38435,Q8N0U8,P52292,O76062,O43292,Q9Y5M8,P48449,Q86YN1,Q5T9L3,Q8NFQ8,Q03519,A1L0T0,Q53GQ0,Q96KC8,Q8N5M9,Q9UBU6,Q9BUN8,O00264,Q96PC5,O14678,Q9NUQ2,Q15363,P27544,P16615,Q07065,Q9Y4P3,Q14534,Q8IV08,Q8TCT9,Q9BUR5,Q96HY6,Q15382,Q96RL7,Q9Y6B6,Q13190,P16435,Q14739,P49755,Q96A33,Q10472,O15260,P42345,Q07812,Q9BT22,Q6NUM9,Q9NZ08,P51571,P35613,O95864,Q2TAA5,Q8NHH9,Q9H3N1,Q15041,Q9BVK6,Q15904,Q9UBM7,P48651,Q96N66,Q6UX53,O15269,Q969V3,Q7Z3C6,O76024,O75845,P61970,P57088,Q12907,O00767,Q9NPA0 115 +Mitochondrial envelope 0.4905063521520062 4.6654860467880335 3.078883891838302e-06 0.0027947970290141 0.0005909714243757 320 Q9NS69,P14406,O43169,Q69YU5,P30536,P45880,Q9H9B4,Q07820,P09601,P17931,P21796,O43676,Q9H061,Q16134,Q8N4H5,O60830,P06576,O75964,Q9UBX3,Q99595,Q9Y584,P23786,Q9BXK5,P03886,Q13505,Q9Y2R0,Q8WY22,O14949,Q96A26,Q9UDW1,Q70HW3,Q9UDX5,P22695,Q9H2D1,O14925,Q15070,Q8N2A8,Q13423,Q8NAN2,Q9H2V7,Q9P0J0,Q567V2,O43772,O95202,P57105,Q9BSK2,Q9Y6C9,P13073,P24539,P12235,Q86Y39,P47985,Q7Z7H8,Q9Y5L4,P00403,O00264,P12236,Q9NZ45,P49748,Q9NUQ2,P52789,Q9NZJ7,Q6P4A7,Q8IYU8,Q7KZN9,Q96CU9,Q9Y619,Q9H4A6,Q9BUR5,Q6DKK2,P21912,Q96RL7,Q9Y277,P0DP25,Q99536,Q96NB2,Q8TB36,P42345,Q15388,Q5XKP0,Q96AY3,Q07812,Q9NPL8,Q99623,Q9NVI7,Q9P032,Q9NUT2,Q96IX5,P14854,Q9BQT8,Q9Y512,Q9Y5J9,Q8NE86,O15228,Q9BWH2,P56385,P04818,Q9Y6M9,Q14197,P22830,Q9BUK6,P51970,P05141,Q9UJZ1 104 +Golgi apparatus 0.4859559053771958 4.65431040397643 3.2506679008559303e-06 0.0029505006167674 0.0005909714243757 326 P80303,Q15392,P24390,P01889,L0R6Q1,P46934,Q6NTF9,Q14108,O00461,Q5VYK3,Q02818,Q9H8H2,P16278,Q16706,Q8TB61,Q9UM00,O95197,Q9UL01,P07305,Q5VW38,P50897,Q8NF37,Q9NPR9,O43731,P20337,P04062,Q9Y282,Q9UQB8,Q14789,O15118,P11166,Q9P2W9,P50851,O14773,Q99523,O75503,Q92544,O60645,O60476,O75592,Q6P6C2,Q8N2A8,Q9Y3B3,Q8IY95,Q93050,Q01968,Q8N4A0,P52292,O14617,Q9BRK5,P62820,O15127,Q7Z6Z7,Q9Y287,Q9H7Z7,Q7LGA3,O95456,P04439,Q96M27,Q86Y82,Q92542,Q5T9L3,Q9NQX7,Q15042,O75063,P53367,P61019,Q8NBN3,Q6ZRP7,Q9NX40,P05067,Q13535,O60512,O43852,O15498,Q96L58,Q8IZA0,Q15363,O43505,Q9NR31,P54646,O95249,P42858,Q9H4A6,Q8IV08,Q9BUR5,Q8TBA6,Q15382,Q96RL7,Q9Y6B6,Q13190,P49755,Q10472,O15260,Q658Y4,P42345,Q92896,P35613,P06280,Q9H9S5,Q9BQS8,Q9BVK6,Q92974,Q7Z3C6,Q9BTU6,Q96SN8,P18085,P49327,Q12907,O00203,P50570,Q9BTV4 112 +Intrinsic component of organelle membrane 0.6120227733841347 4.563325746208363 5.03496013748439e-06 0.0045663327423759 0.000762796460829 124 P01889,L0R6Q1,Q9P035,Q9H9B4,Q86XL3,Q9Y4P3,Q8TCT9,Q9BUR5,Q6NTF9,P20020,Q16134,O60830,P57105,O43819,P42892,O76062,Q9UM00,Q9Y287,Q9Y512,Q8TB61,Q15041,Q8NE86,Q9UBM7,O43292,Q86YN1,Q99595,Q14739,P20337,P12235,Q9BWH2,Q96A33,Q92643,O95470,Q5T9L3,P61020,Q03519,P13473,Q6UXV4,Q13505,Q9Y2R0,O94901,O76024,O75844,Q9Y282,Q03518,Q9BUN8,Q15629,Q96NB2,Q8TB36,O15118,Q15388,P57088,Q5XKP0,O43808,O00767,O43505,Q6P4A7,O14925,Q9NPA0,Q9BTV4,Q15070,Q9NQC3 62 +Golgi membrane 0.5754573867101689 4.336110665517773 1.4502594945620118e-05 0.0130964398457311 0.0018465174423057 136 P35613,Q15392,Q9Y3B3,P24390,O95249,P01889,L0R6Q1,Q9H4A6,Q8IV08,Q9BUR5,Q9H9S5,Q6NTF9,Q14108,O00461,Q8N4A0,P52292,O14617,Q8TBA6,P62820,Q15382,Q16706,Q9UM00,Q9UL01,Q7Z6Z7,Q8TB61,Q9Y287,O95197,Q9BVK6,Q9H7Z7,Q13190,Q7LGA3,Q8NF37,P04439,O43731,Q86Y82,P49755,Q5T9L3,Q10472,O15260,Q7Z3C6,O75063,P53367,P61019,Q8NBN3,Q9Y282,Q6ZRP7,Q14789,P42345,P11166,O60512,Q9P2W9,Q96L58,Q92896,Q8IZA0,Q12907,Q15363,P50570,O43505,O60476 59 +Organelle inner membrane 0.502664057761816 4.311011046680496 1.625097859014879e-05 0.014663685032112 0.0018465174423057 242 P14406,Q69YU5,Q9H9B4,P17931,Q99720,O43676,Q9H061,Q16134,O60830,P06576,O75964,Q9UBX3,Q99595,Q9Y584,P23786,P03886,Q13505,Q9Y2R0,O75844,O14949,Q9UDW1,Q70HW3,Q9H1E5,Q9UDX5,P22695,Q9H2D1,O14925,Q15070,Q13423,Q9H2V7,Q9P0J0,Q567V2,O43772,O95202,Q8IXM6,O76062,Q9BSK2,Q9Y6C9,P13073,P24539,P12235,Q86Y39,P47985,Q7Z7H8,Q9Y5L4,P00403,P12236,P49748,Q6P4A7,Q8IYU8,Q7KZN9,Q96CU9,Q9Y619,Q9BUR5,Q6DKK2,P21912,Q14739,Q96NB2,Q5XKP0,Q9NPL8,Q99623,Q9NVI7,Q9P032,Q9NUT2,Q96IX5,P14854,Q9BQT8,Q9Y512,Q9Y5J9,Q8NE86,P56385,P04818,Q9Y6M9,Q14197,P22830,P61970,P51970,P05141,Q9UJZ1,Q9BTV4 80 +Envelope 0.4131893019814486 4.1871830601632585 2.824380192700815e-05 0.0253472044354237 0.002709298344625 493 P80303,P55060,Q9NS69,P14406,O43169,Q69YU5,P30536,P45880,Q9P035,Q9H9B4,Q07820,P09601,P21796,Q99720,O43676,Q9H061,Q8N4H5,O60830,Q5BJF2,O75964,Q9UBX3,Q99595,Q9Y584,P23786,P41208,Q86UE4,Q9BXK5,P03886,Q13505,Q9Y2R0,Q8WY22,O75844,O14949,Q96A26,Q9UDW1,Q70HW3,O15118,Q9H1E5,Q9UDX5,Q9BTX1,P22695,O15173,Q9H2D1,O14925,Q15070,Q9NQC3,Q8N2A8,Q13423,Q8NAN2,Q9H2V7,Q9P0J0,Q567V2,O43772,O95202,Q8IXM6,P57105,O76062,Q9BSK2,Q9Y6C9,Q96P70,P13073,P24539,P12235,Q86Y39,P47985,Q8NFQ8,Q7Z7H8,Q9Y5L4,Q96KC8,P00403,O00264,P12236,Q9NZ45,P05067,P49748,Q9NUQ2,P52789,Q9NZJ7,Q6P4A7,Q8IYU8,Q7KZN9,Q96CU9,Q9Y619,Q9H4A6,Q9BUR5,Q6DKK2,P21912,Q96RL7,Q9Y277,P0DP25,Q14739,Q99536,O15397,Q96NB2,Q8TB36,P42345,Q15388,Q5XKP0,Q96AY3,Q07812,Q9NPL8,Q99623,Q6NUM9,Q9NVI7,Q15154,Q9P032,Q9NUT2,Q96IX5,P14854,Q9BQT8,P42167,Q9C0E2,Q9Y512,Q9Y5J9,Q8NE86,O15228,Q9UBM7,Q9BWH2,P56385,P04818,Q9Y6M9,Q14197,P22830,P61970,P57088,Q9BUK6,P51970,P05141,Q9UJZ1,Q9BTV4 130 +Vacuole 0.4986813582227233 4.174949148846081 2.980526231710634e-05 0.0267296537230241 0.002709298344625 216 Q07065,P15289,P42858,Q13277,Q15165,Q93050,P06280,Q9UIQ6,Q8IV08,P38435,Q9H2V7,Q14108,Q9BQS8,P11279,Q5BJF2,Q8N511,Q13510,Q9UM22,P42892,Q15382,Q96RL7,P16278,Q14849,Q9H7Z7,Q8NCG7,P42785,P50897,P11117,Q99536,Q16625,P04062,P13473,O15260,Q8WTV0,Q9NQX7,P07602,Q969Q5,P51798,Q8NCC3,Q9Y487,P10253,Q9NX40,O15118,O14678,Q9UHG3,P42345,P17900,Q9BRF8,Q9BTY2,O14773,Q8TBX8,P10619,Q9NZJ7,O75503,Q8NHP8,P54802 56 +Vacuolar lumen 0.6631395756277596 4.0003705516074195 6.32433751257544e-05 0.0558687117215634 0.0035930142493319 66 P15289,Q8IV08,P38435,Q14108,Q13510,Q9UM22,P16278,Q9H7Z7,P50897,P11117,Q99536,P04062,P13473,P07602,P10253,Q9BRF8,P17900,Q9BTY2,O14773,P10619,Q9NZJ7,Q8NHP8,P54802 23 +Lysosomal lumen 0.7592976956428076 3.820429473216734 0.0001332194963437 0.1140587050571217 0.0057665010560204 36 P15289,P06280,Q8IV08,P38435,Q14108,Q13510,Q9UM22,P16278,P50897,P11117,P04062,P13473,P07602,P10253,P17900,O14773,P10619,Q9NZJ7,Q8NHP8,P54802 20 +Outer membrane 0.585627362781791 3.678684180929018 0.0002344403588696 0.1919499428604394 0.0075304230969359 93 Q8N2A8,Q9NS69,O43169,P30536,P45880,Q8NAN2,P09601,Q9BUR5,P21796,Q99720,Q8N4H5,P57105,Q9Y512,Q96RL7,Q9Y277,Q9Y6C9,Q9UBM7,Q9BWH2,Q99536,Q13505,Q8WY22,O00264,Q8TB36,Q9NZ45,P42345,Q15388,P61970,Q5XKP0,Q9NUQ2,P52789,Q07812,Q9NZJ7,Q99623,Q6NUM9 34 +Triglyceride rich plasma lipoprotein particle 0.920361726954487 3.5579956223010325 0.0003736955401894 0.2880536574713773 0.008087839191242 2 Q9UHG3 1 +Inner mitochondrial membrane protein complex 0.5778673606460368 3.4225804089374785 0.0006202974811622 0.4310856367984592 0.009721558799594 76 Q96CU9,Q96IX5,P14406,P14854,Q9BUR5,Q9P0J0,O43676,O60830,P21912,O75964,Q9Y512,Q8NE86,P13073,P24539,Q99595,Q86Y39,Q9Y584,P47985,P56385,P03886,Q13505,O14949,P00403,P12236,Q9UDW1,Q5XKP0,O14925,P22695,Q99623,Q8IYU8 30 +Intrinsic component of vacuolar membrane 0.936230266048786 3.4041497830226652 0.0006637034848033 0.4531095465973083 0.009974819785177 3 O15118 1 +Atp binding cassette abc transporter complex 0.8865227537922933 3.4018239847849747 0.0006693773453199 0.4559247659647941 0.009974819785177 2 O14678 1 +Secondary lysosome 0.8798133022170291 3.370490542295834 0.0007503448162575 0.4945567224681876 0.0106572412184083 2 P13473 1 +Autolysosome 0.8798133022170291 3.370490542295834 0.0007503448162575 0.4945567224681876 0.0106572412184083 2 P13473 1 +Membrane protein complex 0.4222496014515824 3.35997686481463 0.0007794899967903 0.5077815746227715 0.0106966204561303 302 Q13546,Q9NS69,P01889,P14406,P45880,Q6NTF9,P21796,O43676,Q8N4H5,O60830,P42574,Q8N511,O75955,O75964,O15400,P67812,P06576,Q9C0H2,Q99595,O95487,Q9Y584,Q92643,Q6UXV4,P63218,P03886,Q13505,O94901,O14949,Q03518,Q9UDW1,Q9Y487,Q9P2W9,P22695,O14925,Q9Y3B3,Q93050,Q9P0J0,O43292,P13073,Q9Y5M8,P24539,P12235,Q86Y39,P47985,Q03519,Q53GQ0,P00403,Q9UBU6,Q9BUN8,P12236,O14678,Q9NR31,Q8IYU8,O95249,Q13277,Q96CU9,Q9Y5X3,Q8TCT9,Q9BUR5,P21912,Q9Y277,Q9Y6B6,Q13190,P0DP25,P49755,P51798,Q15388,Q5XKP0,Q07812,Q99623,P51571,Q9NUT2,Q96IX5,P14854,Q9Y512,Q15041,Q8NE86,Q15904,P56385,P09429,O15269,Q9Y6M9,P49327,P51970,O00203,P05141,Q9NPA0 87 +Uniplex complex 0.8768961493582205 3.3568285818698427 0.0007884197695937 0.5117639294395613 0.0106966204561303 2 Q8IYU8 1 +Platelet dense granule 0.8646441073512167 3.29918971419787 0.0009696435663173 0.5859769386847393 0.0122417500247565 2 P13473 1 +Zymogen granule membrane 0.9086664721330588 3.2809212886691683 0.0010346861457191 0.609769082484169 0.0125403960861156 3 Q15363,Q13277 2 +Intrinsic component of endoplasmic reticulum membrane 0.6032041400169681 3.256605839884942 0.0011275288560539 0.6413835981882008 0.0134858385546451 54 P01889,Q9Y4P3,Q9P035,Q86XL3,Q8TCT9,Q6NTF9,Q9NZ01,O76062,Q15041,Q9UM00,Q8TB61,Q9HCU5,Q9UBM7,O43292,Q86YN1,O14975,P04439,Q96A33,O95470,Q92643,Q03519,O76024,O75844,Q9Y282,Q03518,Q9BUN8,Q15629,P57088,O00767,Q9NPA0,Q9NQC3 31 +Bcl 2 family protein complex 0.8462660443407265 3.211937120868166 0.0013184322854995 0.698578506603032 0.0146153042380376 2 Q07812 1 +Proton transporting v type atpase v0 domain 0.880974709172187 3.1551661313833272 0.0016040673847563 0.7675936539864372 0.0164303334690894 3 Q9Y487 1 +Vacuolar proton transporting v type atpase v0 domain 0.880974709172187 3.1551661313833272 0.0016040673847563 0.7675936539864372 0.0164303334690894 3 Q9Y487 1 +Dopaminergic synapse 0.8340140023337217 3.1532298793212825 0.0016147459338697 0.7698422640104641 0.0164303334690894 2 O75955 1 +Compact myelin 0.8325554259043085 3.146211837088022 0.001654001599697 0.7779232446832409 0.0165218401552159 2 Q9NR77 1 +Potassium channel complex 0.8775292658772127 3.139379357721785 0.0016930611232943 0.7856825255149503 0.0167281800116802 3 P0DP25 1 +Protein lipid complex 0.8533712102159922 3.0277994937771022 0.0024634147662165 0.893754906792779 0.0221707328959492 3 Q9UHG3 1 +Copi coated vesicle membrane 0.8259507729538134 3.0175000110224977 0.0025486903182394 0.9016985869009336 0.0224928106726181 15 Q8N511,O43731,Q9Y3B3,P24390 4 +Er membrane insertion complex 0.8499815248624032 3.012017456043727 0.0025951767358509 0.9057761543061552 0.0226828428162358 3 P46379 1 +Mitochondrial protein containing complex 0.4402752848849914 2.995297500708598 0.0027417728345495 0.9175608130801478 0.0235619902072594 159 Q9NS69,Q96CU9,Q96IX5,P14406,P14854,Q9BUR5,P21796,Q9P0J0,Q567V2,O43676,Q8N4H5,O60830,P21912,O75964,Q9Y512,Q9Y5J9,Q8NE86,P13073,Q99595,P24539,P12235,Q86Y39,Q9Y584,P47985,P56385,Q7Z7H8,P03886,Q13505,Q9Y5L4,O14949,Q9Y6M9,P00403,P12236,Q14197,Q9UDW1,Q15388,Q5XKP0,Q8IYU8,P22695,P51970,Q07812,Q99623,O14925 43 +Endocytic vesicle membrane 0.6151582986206529 2.991383115050672 0.0027771683208364 0.920178142856677 0.0235619902072594 40 Q5T9L3,Q03519,Q8WTV0,Q93050,Q15907,Q14108,Q03518,Q9Y487 8 +Intrinsic component of mitochondrial membrane 0.606637720663435 2.9906441716012204 0.0027838967984952 0.9206662112029332 0.0235619902072594 43 Q9H9B4,Q9BUR5,Q16134,O60830,P57105,O43819,Q9Y512,Q8NE86,Q99595,Q9BWH2,P12235,Q13505,Q9Y2R0,Q96NB2,Q8TB36,Q15388,Q5XKP0,Q6P4A7,O14925,Q15070 20 +Respirasome 0.5992858563414997 2.980173908690144 0.0028808477926611 0.9273767331318654 0.0235619902072594 45 Q7KZN9,Q13423,Q96CU9,P14406,P03886,P22695,Q9UDW1,P13073,O14949,Q9P0J0,P00403,Q6DKK2,O43676,Q86Y39,P47985 15 +Endosome lumen 0.840229883926203 2.966439634806689 0.0030126949590072 0.9356020329684082 0.0235619902072594 3 Q9UIQ6 1 +Gamma secretase complex 0.7952158693115393 2.9644006615896825 0.0030327314128155 0.9367677972690492 0.0235619902072594 2 P49755 1 +Cis golgi network 0.8004685907412142 2.9479688302104803 0.0031986931486445 0.9456479143605608 0.0240311650537524 16 O95249,P24390,O00461,Q9NPR9,O43731,Q8TBA6 6 +Golgi associated vesicle membrane 0.7251375609342768 2.908385275070027 0.0036330044915062 0.9634258828567313 0.026705594163707 22 Q8N511,Q9Y3B3,P24390,Q9Y287,O43731 5 +Endoplasmic reticulum golgi intermediate compartment 0.5647860719504588 2.887643108731315 0.0038813999509079 0.970842919242153 0.0275640043388698 52 P80303,Q8N511,Q9Y3B3,P24390,Q02818,Q9BVK6,Q10472,Q03519,P09429,O15260,Q12907,Q15904,Q13190,Q15363,P49755,Q9Y282,Q03518,Q5VYK3 18 +Growth cone membrane 0.7704200700116687 2.841326145493183 0.0044926340338555 0.9833109994184056 0.0306468857124526 2 Q9UPT5 1 +Endoplasmic reticulum golgi intermediate compartment membrane 0.6715137093964244 2.812821646207749 0.0049108881432249 0.9886097145053184 0.03234426552062 26 Q8N511,Q9Y3B3,P24390,Q10472,Q9BVK6,Q03519,O15260,Q15904,Q13190,Q15363,Q9Y282,Q03518,P49755 13 +Copi coated vesicle 0.7623663021364835 2.80822666763564 0.0049815150416796 0.9893213986208482 0.03234426552062 17 Q8N511,Q9Y3B3,P24390,Q15363,O43731 5 +Integral component of synaptic vesicle membrane 0.7963233148526326 2.757944072648607 0.0058166148606835 0.9950220638447168 0.0364641579886987 3 O76024,P20020 2 +Vacuolar membrane 0.4550657492371507 2.7514737995575653 0.0059327765476695 0.995523683831438 0.0369146839369062 123 Q07065,O75165,Q93050,Q9UIQ6,Q8IV08,Q9H2V7,Q96DM3,Q14108,P11279,Q15043,Q8N511,O75955,P42892,O15400,Q15382,Q96RL7,Q14849,Q8NCG7,P42785,Q96GC9,P11117,Q16625,P04062,P13473,O15260,Q8WTV0,Q9NQX7,Q7Z3C6,P07602,P51798,Q9BTU6,Q9Y487,P10253,O15118,O14678,P42345,O00203,P10619,Q9NZJ7,O75503 40 +Intrinsic component of mitochondrial inner membrane 0.6333669716431619 2.748408292513808 0.0059885384902129 0.9957462162736472 0.0369146839369062 30 O43819,Q9Y512,Q15070,Q5XKP0,Q8NE86,Q13505,Q9H9B4,Q9Y2R0,Q9BUR5,Q96NB2,Q99595,O14925,Q6P4A7,Q16134,O60830 15 +Cell body membrane 0.7938899773913635 2.7462291679407858 0.0060284637157568 0.9958987267816906 0.0369146839369062 3 P20020 1 +Golgi cisterna 0.6777544418729149 2.7321169210320697 0.0062928804507635 0.9967797701890228 0.0369495637870389 24 O95249,O60512,Q9Y6B6,Q96L58,Q9H4A6,Q15363,Q8NBN3,O00461,Q8TBA6 9 +Death inducing signaling complex 0.8337160679611307 2.7317166221859015 0.006300530678758 0.9968022270815864 0.0369495637870389 4 P49327,Q13546 2 +Cytochrome complex 0.7336871701897308 2.7147501051461935 0.0066325797353212 0.997640009748126 0.0381583226544749 18 P14406,P22695,P13073,O14949,P00403,Q9UDW1,P47985 7 +Transport vesicle 0.4927229935232952 2.706517535202956 0.0067992991468939 0.9979739565038862 0.0386285182782911 91 O95249,Q9Y3B3,P24390,Q13277,P01889,Q92572,Q9BT78,P20020,O00461,Q9Y678,Q8TBA6,P11279,P62820,O75396,O15400,Q9BVK6,Q9Y6B6,Q13190,P0DP25,P50897,P04439,O43731,Q86Y82,P20337,O95487,Q92542,P49755,P61020,O15260,O76024,P05067,O15498,Q99523,Q15907,Q15363,Q9NR31,O75592 37 +Nonhomologous end joining complex 0.8227822695746749 2.681227172258205 0.0073352700884719 0.998759617740717 0.0399007684779682 4 Q13426 1 +Cell tip 0.7322053675612565 2.647861366977286 0.0081002735364028 0.9993845349710978 0.0425615528589028 2 Q9BTU6 1 +Azurophil granule 0.5012150654954494 2.6277357303708744 0.0085955263352812 0.9996091188345624 0.0436499074791657 70 P15289,Q07065,Q13277,O75165,P06280,P11279,O15400,P16278,Q9H7Z7,P42785,Q8NF37,O43681,Q99536,P13473,O15260,Q9NQX7,P07602,P10253,Q9BRF8,P17900,Q9BTY2,P10619,Q9NZJ7 23 +Vesicle membrane 0.3894253266998457 2.6243402327783265 0.0086817012682871 0.999638815831722 0.0438425914048501 273 P35613,P30519,Q13546,P55899,P24390,Q9Y3B3,P01889,O75165,O60831,Q93050,Q07065,P42858,Q13277,Q9Y5X3,P55011,Q9UIQ6,Q8IV08,P17931,Q14108,O00461,Q96DM3,P20020,P11279,Q15043,Q8N511,P42892,O15400,O15127,Q96RL7,Q9UL01,Q9Y287,Q9Y6B6,Q14849,Q15904,Q13190,P42785,Q9Y5X2,P0DP25,Q15057,Q8NF37,Q14728,Q9H223,P20337,O43731,P49755,Q5T9L3,P61020,Q03519,P13473,O15260,Q8WTV0,Q9NQX7,Q7Z3C6,P07602,Q969Q5,O76024,A4D1P6,Q03518,O00264,Q9Y487,P10253,O15118,O00203,Q15907,Q15363,P50570,Q9NZJ7,Q9NR31 68 +Zymogen granule 0.8066090228774528 2.605964597844866 0.0091615930365398 0.9997674187760308 0.0448967619024659 4 Q15363,Q13277 2 +Golgi cisterna membrane 0.708032482096529 2.569638394144224 0.0101804719135689 0.9999087106500456 0.0479484402561357 18 O60512,Q9Y6B6,Q96L58,Q9H4A6,Q15363,Q8NBN3,O00461 7 +Golgi medial cisterna 0.7971395213076251 2.5615748763470383 0.0104198777707598 0.9999267301387132 0.0485726609929265 4 O95249,Q96L58,Q16706 3 +Golgi lumen 0.8277837743899217 2.5583331103021316 0.0105175290142063 0.9999330165690624 0.0487777238464977 5 Q9BRK5,O00461 2 +Tim23 mitochondrial import inner membrane translocase complex 0.8569854397145054 2.5470851435713575 0.0108626925906702 0.9999512209317912 0.0491253112682552 6 Q99595,O14925,O60830 3 +Secretory granule membrane 0.4895606768046596 2.537658301170275 0.0111596884994786 0.9999628736772128 0.0497262590491476 72 P35613,P30519,Q07065,Q13277,P01889,O75165,Q93050,P17931,P11279,P42785,Q8NF37,P49755,P61020,P13473,O15260,Q9NQX7,P07602,Q969Q5,Q4KMQ2,O00264,P10253,Q15363,Q9Y5K8,Q9NZJ7,O60645 25 +Nucleotide excision repair complex 0.8194451315980185 2.520306715981872 0.0117252614090661 0.999977928885784 0.051739138936122 5 P41208 1 +Torc1 complex 0.6998249708284496 2.4802408102444025 0.0131293678763053 0.9999939389944164 0.0560309643171905 2 P42345 1 +Tor complex 0.6998249708284496 2.4802408102444025 0.0131293678763053 0.9999939389944164 0.0560309643171905 2 P42345 1 +Respiratory chain complex iii 0.8234339382813267 2.4743152201113925 0.0133491855709386 0.999995050034785 0.0567028489905759 8 O14949,P22695,Q9UDW1 3 +Postsynaptic recycling endosome 0.6966161026837869 2.4634421824259665 0.0137610087675321 0.999996613187491 0.0576440413349619 2 Q86Y82 1 +Postsynaptic endosome 0.6966161026837869 2.4634421824259665 0.0137610087675321 0.999996613187491 0.0576440413349619 2 Q86Y82 1 +Golgi associated vesicle 0.5797553281851873 2.4591904145989893 0.0139250739218419 0.999997088522962 0.0580637256649281 33 Q8N511,P05067,Q9Y3B3,P24390,Q9Y287,Q15363,O43731 7 +Intrinsic component of plasma membrane 0.4776741676964507 2.446048665507451 0.0144431503771713 0.9999981942912716 0.0599489666340126 78 P35613,P53985,P01889,P55011,Q8NAN2,Q9UIQ6,O95864,P20020,O60637,P11279,Q15043,O76062,O15031,P0DP25,O43657,O96005,P12235,Q8WTV0,Q9BTU6,O00264,P30825,P05067,O15118,Q12907,Q99797,P05141,P16615 27 +Golgi stack 0.5666255918979236 2.3934398858799892 0.0166912162541916 0.9999997734646056 0.0680372895742611 34 O95249,Q16706,Q10472,O60512,Q9Y6B6,Q01968,Q96L58,Q9H4A6,Q99523,Q15363,Q8NBN3,O00461,Q8TBA6,Q14789 14 +Platelet alpha granule membrane 0.6799883313885668 2.375848497323748 0.0175086500275489 0.9999998936296638 0.0710507271207233 2 Q6YHK3 1 +Anchored component of synaptic vesicle membrane 0.7543132388293239 2.3578027912342057 0.0183834561758238 0.9999999526675344 0.0742691629503282 4 P61020 1 +Coated vesicle membrane 0.4903119716828176 2.340917070837512 0.0192364394106556 0.9999999785232592 0.0764947819408859 60 Q8N511,Q9Y3B3,P24390,Q9Y6B6,Q13190,Q15363,Q14108,Q9NR31,O43731 9 +Cyclin cdk positive transcription elongation factor complex 0.7112342719044933 2.3379863550202846 0.0193879559921836 0.9999999813372468 0.0764947819408859 3 P50750 1 +Mhc class i protein complex 0.7020116500271805 2.2911725956013185 0.0219534332757982 0.9999999982748956 0.0830747448213722 3 P01889 1 +Mhc protein complex 0.7020116500271805 2.2911725956013185 0.0219534332757982 0.9999999982748956 0.0830747448213722 3 P01889 1 +Microbody membrane 0.5862249956586152 2.2461051442950786 0.0246972739270565 0.999999999865801 0.0908899676100988 26 Q6IAN0,Q15067,O14678,Q9NR77,O15228,O75381,O00116,P51648,O43808,Q8TB36 10 +Mitochondrial intermembrane space protein transporter complex 0.6910462185457955 2.2351798134226697 0.025405546202128 0.9999999999306642 0.0927455481836724 3 Q9Y5L4 1 +Haus complex 0.7241972971320314 2.211522925127896 0.0269996461354713 0.9999999999843427 0.0958698372544666 4 O94927 1 +Mitochondrion 0.329769988633342 2.202485841642571 0.0276310081560624 0.9999999999913208 0.0962321318538727 641 Q9NS69,Q16740,Q15165,P14406,O43169,Q69YU5,P30536,P45880,P09601,P21796,O43676,Q9H061,Q8N4H5,O60830,O75964,Q9NPH0,Q14849,Q9UBX3,P00374,Q99595,Q9Y584,P23786,Q9BXK5,P03886,Q13505,Q9Y2R0,Q9NUJ1,Q8WY22,O14949,Q96A26,Q9UDW1,Q70HW3,Q9UDX5,P22695,Q3SXM5,Q9H2D1,O14925,Q15070,Q8N2A8,Q13423,Q8NBX0,Q8NAN2,Q9H2V7,Q9P0J0,Q567V2,O43772,O95202,P57105,Q9BSK2,Q9Y6C9,Q9H7Z7,O43292,P13073,P24539,P12235,Q86Y39,Q9H773,P47985,Q9NWS8,Q7Z7H8,Q9Y5L4,O00116,P00403,O00264,P12236,Q9NZ45,P49748,Q9NUQ2,P52789,Q9NZJ7,Q6P4A7,Q8IYU8,Q7KZN9,Q96CU9,Q9Y619,O43572,Q9H4A6,Q9BUR5,Q9H2U1,Q6DKK2,P21912,Q96RL7,Q9Y277,Q9NR77,P0DP25,Q9NUQ9,P16435,Q99536,Q9UMX5,P14735,Q9HC38,Q96NB2,Q8TB36,P42345,Q15388,Q16836,Q5XKP0,Q96AY3,Q07812,Q9NPL8,Q99797,Q8TAE8,Q99623,Q9NVI7,P35613,Q9P032,Q9NUT2,Q96IX5,P14854,P14635,Q9BQT8,Q9Y512,Q9Y5J9,Q8NE86,O43708 115 +Nuclear cyclin dependent protein kinase holoenzyme complex 0.7176052401160473 2.1791745706342582 0.0293187022568646 0.9999999999982108 0.1005295202451572 4 P50750,Q9P287 2 +Intrinsic component of synaptic vesicle membrane 0.7664666669391581 2.1720947470455525 0.0298485171194464 0.9999999999989106 0.1008604243457836 7 P61020,P20337,P20020,O76024 4 +Coated vesicle 0.4440667379736309 2.163956098053162 0.0304677189119928 0.9999999999993904 0.1010543302820176 90 Q9Y3B3,P24390,P01889,Q14108,Q8N511,P42892,Q9BVK6,Q9Y6B6,Q13190,Q5VW38,P49755,O43731,Q9Y282,P05067,Q12907,O00203,Q15363,P50570,Q9NR31 19 +Respiratory chain complex iv 0.7320199510059185 2.161481616160703 0.0306581555394231 0.99999999999949 0.1010543302820176 11 P14406,P22695,P13073,P00403,P47985 5 +Mismatch repair complex 0.676101546542173 2.15828725839401 0.030905504750716 0.9999999999995955 0.1010543302820176 3 P52701,P43246 2 +Mitochondrial permeability transition pore complex 0.7411011300574156 2.1544417963029003 0.031205541799596 0.9999999999996948 0.101306562485117 5 Q07812,P12235,P21796 3 +Intrinsic component of golgi membrane 0.757230499561806 2.128747323387386 0.033275171240015 0.9999999999999564 0.1072593285715377 7 O15258,Q8TB61,L0R6Q1,Q9Y282,O43505,Q6ZRP7 6 +Copii coated er to golgi transport vesicle 0.5487978822408998 2.121106015155052 0.033912881872862 0.999999999999976 0.1085451043043365 29 P05067,Q9Y3B3,Q9BVK6,P01889,Q9Y6B6,Q12907,Q13190,Q15363,P49755,Q9Y282,Q9NR31,Q5VYK3 12 +Intrinsic component of peroxisomal membrane 0.7025685931114853 2.104946943727595 0.0352959267242134 0.9999999999999934 0.1121053261417253 4 Q8WVX9,O43808,O14975 3 +Extrinsic component of endosome membrane 0.7015350346860667 2.0998224473415696 0.0357444628465193 0.9999999999999958 0.1121053261417253 4 Q9Y5X3 1 +Polar microtubule 0.6286464410735199 2.0995871337676144 0.035765175556766 0.9999999999999958 0.1121053261417253 2 Q96CW5 1 +Proteasome core complex beta subunit complex 0.7498666276299767 2.0940385038718063 0.0362565504255025 0.9999999999999972 0.1124819260641018 7 P20618,P28074,P49721,P28072 4 +Pore complex 0.7254618161497807 2.087215101712662 0.0368686949763705 0.9999999999999986 0.1136055719780367 10 Q9Y277,P45880,Q07812,P21796,P12235 5 +Derlin 1 retrotranslocation complex 0.6920622022499836 2.052721779092036 0.0400995685529528 1.0 0.1197215538506239 4 Q9BUN8 1 +Phagocytic vesicle membrane 0.5803562793795783 2.0519903693314836 0.0401705983767219 1.0 0.1197215538506239 23 Q03519,P13473,Q93050,P50570,Q15907,Q9Y487,Q03518,P11279 8 +Azurophil granule membrane 0.5849028433978027 2.036087505394449 0.0417415691607812 1.0 0.1231079249880939 22 Q07065,P13473,O15260,O75165,Q9NQX7,P07602,P42785,Q9NZJ7,P11279,P10253 10 +Postsynaptic density membrane 0.7221898875663985 1.9962328135831628 0.0459085873025308 1.0 0.1308906108720629 8 Q99720 1 +Mpp7 dlg1 lin7 complex 0.6076429404900896 1.9840699844183 0.047248038682633 1.0 0.1336721873444221 2 Q5T2T1 1 +Parallel fiber to purkinje cell synapse 0.6061843640606864 1.975995170154695 0.0481553242280232 1.0 0.1341750090596692 2 P23634 1 +Atpase dependent transmembrane transport complex 0.6766487332751205 1.9755737053103164 0.0482030791893965 1.0 0.1341750090596692 4 O14678 1 +Outer mitochondrial membrane protein complex 0.6213930897137819 1.954264343694052 0.0506699633403855 1.0 0.1395727172012437 16 Q15388,Q9NS69,Q5XKP0,Q13505,Q9BUR5,Q8N4H5 6 +Golgi apparatus subcompartment 0.4246975213576494 1.9437930235218857 0.0519204154039705 1.0 0.1425850682846199 90 O95249,Q9H4A6,O00461,Q5VYK3,Q8TBA6,O15127,Q16706,Q9Y6B6,Q9NPR9,Q5T9L3,P04062,Q10472,Q7Z3C6,Q658Y4,P53367,Q8NBN3,Q9BTU6,Q14789,P05067,O60512,Q96L58,Q99523,Q15363,P50570,O75592 25 +Endosome 0.3549556013966424 1.929890299349604 0.0536204316356461 1.0 0.14485020585715 237 P35613,Q13546,P55899,P42858,Q8IY95,P01889,O75165,O60831,Q93050,Q01968,Q9Y5X3,Q2M389,Q9UIQ6,Q9H4A6,Q8IV08,Q14108,O00461,Q96DM3,Q8IZ07,Q9BQS8,Q5VYK3,O14617,P11279,Q9BRK5,P62820,O75955,Q13510,O15400,O15127,P42892,Q9Y287,Q96RL7,Q15043,Q14849,Q15904,Q9Y5W7,Q9UBN7,Q9Y5X2,Q5VW38,Q15057,Q9H223,P20337,P04439,Q86Y82,Q5T9L3,Q9BXW6,P61020,P09429,P13473,Q7Z3C6,P07602,Q969Q5,A4D1P6,Q9BTU6,Q9BUN8,Q9Y487,Q9NX40,P05067,O15118,O94832,Q96J02,Q99523,O14773,Q15907,P50570,Q9NZJ7,Q92544 67 +Hrd1p ubiquitin ligase erad l complex 0.6939283688518825 1.9266758145815912 0.0540200437685081 1.0 0.14485020585715 5 Q9BUN8 1 +Dystrophin associated glycoprotein complex 0.5927654609101625 1.901391294182625 0.0572507789992697 1.0 0.1516412943453656 2 Q13425 1 +Glycoprotein complex 0.5927654609101625 1.901391294182625 0.0572507789992697 1.0 0.1516412943453656 2 Q13425 1 +Epsilon dna polymerase complex 0.659369527145344 1.8883506267399488 0.0589788949411798 1.0 0.1536301770777487 4 Q9NRF9,Q07864,Q9NR33 3 +Intrinsic component of postsynaptic density membrane 0.6243511029870628 1.8869334141296037 0.0591692821489897 1.0 0.1536301770777487 3 Q15334 1 +Dna repair complex 0.5808534128871157 1.8675000504016588 0.0618317897897635 1.0 0.1592212377305809 19 P28340,P41208,Q13315,Q13426 4 +Alpha dna polymerase primase complex 0.6546993578517203 1.8646454391443632 0.0622311192122473 1.0 0.1597968569602622 4 P25205,P49642,P49643 3 +Rough endoplasmic reticulum 0.4940491875999261 1.860176976217768 0.0628604913477013 1.0 0.160958272211438 35 Q07065,P05067,Q15041,P51571,Q8TCT9,Q9H9S5,Q9Y5M8,Q9UQB8,Q96A33,Q5BJF2 10 +Azurophil granule lumen 0.4668789334661272 1.851620672806769 0.0640803123549629 1.0 0.1619110356287617 44 P15289,P16278,Q9BRF8,P17900,Q9BTY2,Q9H7Z7,P06280,P10619,Q99536 9 +Transport vesicle membrane 0.4695726987507648 1.84398767771255 0.065184935999256 1.0 0.1636826155340434 42 P62820,P61020,Q9Y3B3,P01889,Q9Y6B6,Q13190,P0DP25,O76024,Q15907,Q15363,P20337,P20020,Q9NR31,O95487,P04439,P49755,O75592 17 +Exocyst 0.6963588989223687 1.83796016734319 0.0660682750499217 1.0 0.1637172075368793 7 Q96KP1,Q9UPT5,O60645 3 +Phosphatidylinositol 3 kinase complex 0.6494136555297688 1.8377500394589 0.0660992466072989 1.0 0.1637172075368793 4 Q14457 1 +Excitatory synapse 0.70107684269287 1.830489037919521 0.0671768444797329 1.0 0.165934107695862 6 Q9UQB8 1 +Dynactin complex 0.6725943807064702 1.821892523664983 0.0684712949463914 1.0 0.1686731899898912 5 O75935 1 +Autophagosome 0.5183657455920437 1.8199134450194387 0.0687721870891817 1.0 0.168956535308287 27 P42858,P13473,Q7Z3C6,Q969Q5,Q8TBX8,Q9BQS8,P11279 7 +Endocytic vesicle 0.4158146287338206 1.815800526289585 0.0694009765437677 1.0 0.1700417457635711 86 P01889,Q93050,Q14108,O00461,Q5VYK3,P11279,Q9H223,Q5T9L3,P61020,Q16625,Q03519,P13473,Q8WTV0,Q969Q5,Q03518,Q9Y487,P42345,Q15907,P50570 19 +Ciliary transition zone 0.6727185668647426 1.7864165252017532 0.0740318419156456 1.0 0.1789759156950049 9 A6NIH7 1 +Er ubiquitin ligase complex 0.6853501248975723 1.784458113087663 0.0743492553281728 1.0 0.1792665068788039 7 Q9UBU6,Q9BUN8 2 +Nuclear inner membrane 0.5403233787888085 1.7826730281967362 0.0746395443679723 1.0 0.1793323733172342 23 Q14739,P61970,O76062,Q9H1E5,O94901,O75844,Q14728,Q99720,Q9BTV4,Q8IXM6 10 +Dendrite terminus 0.6384736596976712 1.7818656484719704 0.07477114355031 1.0 0.1793323733172342 4 Q7L576,Q9Y366 2 +Proton transporting two sector atpase complex proton transporting domain 0.6623564983809324 1.7341561429752907 0.0828903822000837 1.0 0.1949678185234873 9 Q93050,O75964,Q9Y487 3 +Origin recognition complex 0.6540926021449642 1.7301739129504323 0.0835992077009737 1.0 0.1953513619542034 5 Q9Y619,P33993,Q9UBD5 3 +Postsynaptic specialization membrane 0.6331301763891612 1.7239920340927504 0.084709281227725 1.0 0.1962512646546672 12 Q99720,P52292 2 +Transporter complex 0.4264399439812631 1.6916691350026274 0.0907090765410434 1.0 0.206653008961926 58 Q9NUT2,Q96CU9,Q9P0J0,O43676,Q9Y5J9,Q8NE86,Q9C0H2,P0DP25,Q86Y39,P47985,P03886,Q9Y5L4,O14949,Q9Y6M9,P51798,Q9UDW1,O14678,P22695,Q8IYU8 19 +Organelle membrane contact site 0.5609413788242648 1.6887663792425125 0.0912642091903133 1.0 0.2073686600076568 18 Q9BXW6,Q15388,Q5XKP0,Q14849,O43865,Q96N66 6 +Nata complex 0.5545507584597572 1.6859490173470604 0.0918056195355421 1.0 0.2075903188005168 2 Q9BXJ9 1 +Mcm complex 0.6679322429906611 1.6710351782946475 0.0947147295735451 1.0 0.2120583477397844 6 P49736,P25205,P33991,P33993,Q14566 5 +Cell trailing edge 0.6398480315250321 1.659053911113418 0.0971049293291357 1.0 0.2146885787391148 5 O75955,P26038 2 +Lipid droplet 0.4737336105019664 1.6439998831898963 0.1001762265047612 1.0 0.2199521494995844 33 Q07065,Q96RL7,Q8NBX0,P48449,Q99720,Q01105,Q6UX53 7 +Juxtaparanode region of axon 0.6091652072387583 1.630773694224199 0.1029380800499133 1.0 0.2240500084335641 4 Q14168,Q15334,Q8IXJ6 3 +Proton transporting two sector atpase complex 0.5240278283546006 1.6303454976506822 0.1030284967274255 1.0 0.2240500084335641 22 Q8N511,O75964,Q93050,Q96IX5,Q15904,P24539,Q9Y487 7 +Postsynaptic specialization intracellular component 0.6062990899591983 1.615897093931851 0.1061165640498962 1.0 0.2280377227455216 4 Q9UQB8 1 +Postsynaptic density intracellular component 0.6062990899591983 1.615897093931851 0.1061165640498962 1.0 0.2280377227455216 4 Q9UQB8 1 +Postsynaptic cytosol 0.6304681189547656 1.6119959394521477 0.1069628233334489 1.0 0.2293141660615686 5 Q9UQB8 1 +Dna polymerase complex 0.6239461627542239 1.6044636221271706 0.1086118968479101 1.0 0.2317563714430759 11 P25205,P49643,P49005,Q9NRF9,Q9NR33,P28340,Q9NRG0,P49642,Q07864 9 +Cyclin dependent protein kinase holoenzyme complex 0.6067618040981066 1.581225827261519 0.1138264120150767 1.0 0.2389013631053836 12 O95067,P11802,P50750,P14635,P06493,Q00535,Q9P287 7 +Dna replication preinitiation complex 0.6195279853921738 1.5810826585279325 0.1138591392684911 1.0 0.2389013631053836 11 P49736,P25205,Q9Y248,Q9BRT9,P33991,Q14691,P33993,Q9UBD5,Q14566 9 +Endoplasmic reticulum tubular network membrane 0.5965889988882894 1.5653731729761984 0.1174954349095809 1.0 0.2410910842727066 4 Q9NQC3 1 +Exocytic vesicle 0.453117522098139 1.552607700182609 0.1205168849362656 1.0 0.2456274627961109 36 P61020,P05067,O15400,Q13277,Q9BVK6,P0DP25,O76024,Q15907,Q9BT78,P20020,P50897,P20337,Q86Y82,P11279 14 +Ap 3 adaptor complex 0.5618824622367116 1.5496601270727015 0.1212231131142009 1.0 0.2465141159302207 3 O14617 1 +Snare complex 0.5867243352801331 1.5426959078009692 0.1229045752515234 1.0 0.248820175731926 13 O95249,O15400,Q13277,O15498,Q9P2W9,Q13190,Q86Y82 7 +Oxidoreductase complex 0.4033118190504673 1.4957668240991824 0.1347144295467972 1.0 0.2633449816301907 62 Q96CU9,O43169,P03886,P22695,Q9UDW1,O14949,Q9P0J0,O43676,Q86Y39,P47985 10 +Late endosome 0.3915892758862486 1.490817680267526 0.1360093685932859 1.0 0.2647377217372524 71 P42858,Q8IV08,Q14108,Q96DM3,Q9BQS8,Q5VYK3,P11279,Q9BRK5,Q15043,Q14849,Q9UBN7,Q9BXW6,P13473,Q7Z3C6,P07602,A4D1P6,Q9BUN8,O15118,Q9NZJ7 19 +Gamma tubulin complex 0.5447913627079214 1.455840949845145 0.1454365926195397 1.0 0.278906883314687 3 Q96CW5,P38398 2 +Micos complex 0.5972978547514247 1.4443030569456003 0.1486537462716066 1.0 0.2826909107968419 5 Q9BUR5,Q5XKP0,Q6UXV4 3 +Proton transporting v type atpase complex 0.5808255381877387 1.4392937710179676 0.1500673069394167 1.0 0.2843133456086491 12 Q8N511,Q9Y487 2 +Phagocytic cup 0.5674400387983234 1.412679725732117 0.1577499154296631 1.0 0.2956591198465232 4 Q9Y5X3 1 +Mitochondrial proton transporting atp synthase complex coupling factor f o 0.5906346306474727 1.4104082218819711 0.1584191790580766 1.0 0.2956941145047057 5 P24539,O75964 2 +Proteasome core complex 0.5363454594262314 1.4028700225825448 0.1606556015518259 1.0 0.2992539791201019 15 P20618,P28072,P60900,P28074,P49721,Q92530 6 +Dendritic shaft 0.6090774007940715 1.382963481140669 0.1666760637025031 1.0 0.3066974532501524 6 Q9UQB8 1 +Dense core granule membrane 0.4979579929988361 1.3600796211243538 0.1738047291869024 1.0 0.3185251992558354 2 Q709C8 1 +Membrane microdomain 0.3830673229335148 1.3381623090652424 0.1808435327133746 1.0 0.3269159994294986 67 P35613,P05067,Q13546,P49327,O15118,P13473,Q8WTV0,Q9UBN7,O14773,P09601,P21796,P50897,P20020,Q9BTU6,P05141,Q9UJZ1,P42574 17 +Mitotic spindle microtubule 0.5949474788888452 1.313097056293399 0.1891502456714993 1.0 0.3391518249238247 6 O94927 1 +Ribose phosphate diphosphokinase complex 0.5185293259410709 1.3107641796016465 0.1899374479612141 1.0 0.3392006683629541 3 Q14558,P11908 2 +Myosin filament 0.5164867230814266 1.299445763005105 0.1937909952378844 1.0 0.3433836746595194 3 Q7Z406,P35579 2 +Nuclear outer membrane 0.5722990515193631 1.2988766032249726 0.1939862802261949 1.0 0.3433836746595194 10 Q6NUM9,Q99720,P61970,Q9UBM7 4 +Phagocytic vesicle 0.4077325420772666 1.292499225977003 0.1961843138093553 1.0 0.3456037621176434 42 O75396,P42345,Q12965,Q03519,P01889,P13473,Q93050,Q01968,P50570,Q15907,Q9Y487,Q03518,P04439,Q86Y82,P11279,Q14457 16 +Glial cell projection 0.5620245038178242 1.264298911194695 0.2061227602524784 1.0 0.3596268504213107 5 P05067 1 +Specific granule membrane 0.522804869844084 1.2473165159040276 0.2122814639155632 1.0 0.3689557374746596 14 O00264,P30519 2 +Autophagosome membrane 0.556937679852878 1.2461434702844916 0.2127117281766244 1.0 0.3689980170086862 11 Q7Z3C6,P13473,P11279 3 +Nucleotide activated protein kinase complex 0.5338803032603617 1.235491778281914 0.2166475344666185 1.0 0.3743965947341374 4 P54646 1 +Caveola 0.4986637545109608 1.2111377973333808 0.2258425974377651 1.0 0.3873413605111859 16 P09601 1 +Chromatoid body 0.4705367561260282 1.200350047847899 0.2300034201740721 1.0 0.391670607275024 2 Q08J23 1 +Ficolin 1 rich granule membrane 0.477090588849447 1.1967935352810564 0.2313870386566938 1.0 0.3924701779786198 19 P13473,Q93050,P42785,P11279,P10253 5 +Calcium and calmodulin dependent protein kinase complex 0.4687864644107379 1.1901401096026412 0.2339913278189533 1.0 0.3953496598279342 2 Q13555 1 +Transcription factor tfiid complex 0.5582993411141663 1.1739231617524772 0.2404258041840585 1.0 0.4039686802279283 8 P35269 1 +Synaptic vesicle membrane 0.5203758746242734 1.1659465876856228 0.2436360413687734 1.0 0.4071050764783366 13 P61020,P0DP25,Q15907,O76024,P20020,P20337 6 +Rough endoplasmic reticulum membrane 0.5075823672749373 1.157700387141006 0.2469863259264062 1.0 0.4096908216552979 14 Q9Y5M8,Q5BJF2,Q96A33,P51571 4 +Blood microparticle 0.4833146671348924 1.1535049640357509 0.2487031812473872 1.0 0.4110385304615909 17 P11166,P04062,P02786,Q08380,P38435 5 +Cytosolic large ribosomal subunit 0.3870090960616765 1.147457271534856 0.2511926828573447 1.0 0.412290667050664 46 P46778,P26373,P62910,P46779,P46776,P84098,Q9Y3U8,Q07020,P83731,P27635,P42766,P62917,P62424,P47914,P61513,P61927,P83881,P36578,Q02878,P39023,P62750 21 +Cul4b ring e3 ubiquitin ligase complex 0.4884738838634515 1.1439897417444989 0.2526278912953796 1.0 0.413763519256757 3 Q9NZJ0,Q16531 2 +Endosome membrane 0.3297734139312657 1.141500201976303 0.2536618279919533 1.0 0.4143141814585048 135 Q13546,P55899,P01889,O75165,O60831,Q93050,Q9Y5X3,Q8IV08,Q14108,O00461,Q96DM3,P11279,Q15043,P42892,O15400,O15127,Q96RL7,Q9Y287,Q14849,Q15904,Q15057,Q9H223,Q5T9L3,P61020,P13473,Q7Z3C6,A4D1P6,Q9Y487,O15118,Q15907 30 +Cell pole 0.4872557213648952 1.137227492095553 0.2554431969470656 1.0 0.4161252079298972 3 Q9BTU6 1 +Mitochondria associated endoplasmic reticulum membrane 0.5378112115456659 1.0914191442266992 0.2750884923171022 1.0 0.4364850232593389 9 Q15388,O43865,P27824,Q9Y320,Q96N66 5 +Proton transporting atp synthase complex coupling factor f o 0.5469723779276034 1.0750824751718842 0.2823378047965605 1.0 0.4432557246287971 6 P24539,O75964 2 +Presynaptic cytosol 0.5235347737451362 1.0671158645493186 0.2859195187949443 1.0 0.4473336361180799 5 Q9UQB8 1 +Er to golgi transport vesicle membrane 0.4408548820368805 1.0553780142551477 0.2912524739731945 1.0 0.4525952243498553 22 Q9Y3B3,P01889,Q9Y6B6,Q13190,Q15363,Q9NR31,P49755 7 +Myosin ii complex 0.4997081144191532 1.0546182201339869 0.2915999673620004 1.0 0.4525952243498553 4 Q7Z406,P35580,P35579 3 +Proton transporting atp synthase complex 0.5259754591789796 1.053283648468884 0.2922110107932347 1.0 0.4525952243498553 10 Q96IX5,O75964,P56385,P24539 4 +Nadh dehydrogenase complex 0.4293981775088376 1.0382725504854875 0.2991431843113235 1.0 0.4597042720806001 24 O43676,P03886,Q86Y39,Q9P0J0 4 +Intrinsic component of mitochondrial outer membrane 0.5179538642930519 1.0357049046713884 0.3003398335033322 1.0 0.4600104222225747 11 P57105,Q15388,Q8TB36 3 +Mib complex 0.5223528886063336 1.0340859763909067 0.3010959715967409 1.0 0.4600104222225747 10 Q9Y512,Q5XKP0,Q6UXV4,Q13505,Q9BUR5,Q16891 6 +Trans golgi network membrane 0.4457180617079232 1.0316054616725194 0.3022569807785169 1.0 0.4602204280195509 20 P53367,O15127 2 +Calcium channel complex 0.524940516565549 0.9835923349235656 0.3253159954382629 1.0 0.486368815548324 7 P0DP25,Q8IYU8 2 +Unconventional myosin complex 0.4848219497956857 0.9760889893915616 0.3290203672175762 1.0 0.4910993658469241 4 Q12965,P60660,Q9UM54 3 +Barr body 0.4799998309455438 0.9507292173603196 0.3417418524141349 1.0 0.5059337847629457 4 P84243 1 +Sex chromatin 0.4502480303472551 0.9325135015324144 0.3510712124122292 1.0 0.5172183664225549 3 Q15022,O75367 2 +Microbody 0.3509119345054734 0.9238287529739392 0.3555754824286126 1.0 0.5218430182274267 60 Q6IAN0,Q15067,O14678,P14735,O15228,Q9NR77,O75381,A8MXV4,Q13315,Q8N4Q0,O00116,P51648,Q8WVX9,O15254,O43808,Q96CN7,Q9UBQ7,Q8TB36 18 +Presynaptic active zone membrane 0.4948517720449112 0.9208293911665604 0.3571395074932209 1.0 0.522769424011816 5 Q13277 1 +Chloride channel complex 0.5122522298540437 0.9035550797928358 0.3662313695022505 1.0 0.5343568457103463 6 P51798,Q9C0H2 2 +Neuron projection terminus 0.4715560434107525 0.8873917532934607 0.3748680218705469 1.0 0.5403654490203398 13 Q7L576,O14617,Q9UQB8,Q13641 4 +Cytoplasmic ubiquitin ligase complex 0.4932993316335656 0.8807307813819766 0.3784635521603565 1.0 0.543480835566768 10 Q9UBU6,Q9BUN8 2 +Endoplasmic reticulum protein containing complex 0.3414127357105552 0.8758548607881563 0.3811089413800703 1.0 0.5455559491566676 67 Q6NUQ1,Q8TCT9,P13674,Q6NTF9,P67812,Q15041,O43292,Q15005,Q9Y5M8,O43681,Q92643,Q03519,O15269,Q53GQ0,Q03518,Q9UBU6,Q9BUN8,P46977,Q9NPA0,P51571 20 +Eukaryotic translation initiation factor 2 complex 0.4341990078786293 0.8446800968817497 0.3982894749130621 1.0 0.5674688600250368 3 P20042,P05198 2 +Cytosolic ribosome 0.3334691708960526 0.8263207328623882 0.4086221754981616 1.0 0.5778114379648892 77 P46781,P46778,P26373,P62753,P62910,P46779,P46776,P84098,P62841,Q9Y3U8,Q07020,P83731,P27635,P42766,Q7Z478,P62917,P61353,P62424,P62266,P47914,P61513,P62701,P61927,P83881,P62277,P36578,Q02878,P62847,P39023,P62269,P62750 31 +X chromosome 0.4761006927075087 0.8261360800200069 0.4087269027628424 1.0 0.5778114379648892 5 P84243 1 +Phagophore assembly site 0.4785160700602524 0.8241745728393807 0.4098403725646391 1.0 0.5781961850693985 11 Q6PHR2,Q9H6U6,Q7Z3C6,Q9Y2L5,Q96GC9,Q86Y82,Q14457 7 +Pericentriolar material 0.4551545686112833 0.8210270514293716 0.4116308597527824 1.0 0.5781961850693985 4 Q15154 1 +Golgi transport complex 0.4535901926444897 0.8129298509785768 0.4162582785738662 1.0 0.5821211926517605 4 Q9UP83,P83436,Q96MW5 3 +Apical dendrite 0.4513722172744157 0.8014669012338939 0.4228613981703701 1.0 0.5877385488331291 4 O94832 1 +Apical part of cell 0.338523223451172 0.7748066479340163 0.438453920411245 1.0 0.6029570554520752 56 O75955,Q15154,Q16625,Q13277,P53985,P41208,Q86UE4,P05067,P55011,Q99797,P20020,P08183,Q9Y6M7,P30825,Q15043 15 +Recycling endosome 0.3511215215121681 0.7667589220857877 0.4432248637456655 1.0 0.6053077587875834 41 P05067,O15400,O15127,P61026,P01889,Q96BR1,P02786,Q7Z3C6,O14773,Q15907,Q9H223,P04439,Q86Y82 13 +Trans golgi network 0.3350463250912222 0.766308413435362 0.4434928133691205 1.0 0.6053077587875834 62 Q5T9L3,P05067,O15127,P04062,Q7Z3C6,Q9H4A6,Q658Y4,P53367,P50570,Q9BTU6,Q9NPR9 11 +Plasma membrane raft 0.3942999570472633 0.757398844862318 0.4488109479716433 1.0 0.6098193598000355 23 P09601 1 +Mmxd complex 0.4156116053785124 0.7442952113976227 0.4566978976340206 1.0 0.6186861236204542 3 P05141 1 +N terminal protein acetyltransferase complex 0.4375364856976121 0.7304758870757546 0.4650993468649997 1.0 0.6228881403170367 4 Q5VZE5,Q9GZZ1,Q9BXJ9 3 +Mhc class i peptide loading complex 0.4765641200003564 0.7301775224648775 0.4652816801708117 1.0 0.6228881403170367 6 Q03518 1 +Lumenal side of membrane 0.4629630473608915 0.7229392083430848 0.4697172336709716 1.0 0.6279014197160488 10 Q8TCT9,P04439,P01889,P10619 4 +Perinuclear region of cytoplasm 0.2843379993425581 0.6999951096811435 0.48393035849397 1.0 0.6407861267337108 195 Q07065,P42858,Q8IY95,Q93050,O95684,O94788,Q9Y5X3,Q9UIQ6,P46934,P09601,Q6NTF9,Q8N4A0,Q7L576,P11279,P55327,P42892,O15400,P16278,Q9H7Z7,Q9UBN7,Q9H223,P43034,P20337,Q99584,Q8IXJ6,Q10472,Q86UE4,Q9NQX7,O95071,Q96SN8,Q92530,Q01105,Q9Y487,O75935,O14965,O75190,O75569,O15118,P05067,Q9H6S0,Q99523,P50570,O75503,O60645,O75592 45 +Basal part of cell 0.3343198169124488 0.6980486618688029 0.4851467623476497 1.0 0.6407861267337108 51 P35613,O75955,P57105,Q96N67,P53985,O94832,P55011,P14735,P42785,P20020,Q9Y6M7,P30825,Q15043 13 +Clathrin coated vesicle 0.3364929027121501 0.6858463464973845 0.4928100068455334 1.0 0.6445529442051654 48 P42892,Q9BVK6,O00203,Q5VW38,Q14108,P49755 6 +Early endosome membrane 0.332185247341369 0.6352726034826878 0.5252506383673146 1.0 0.673712832039661 47 P61020,Q5T9L3,O15400,P01889,O75165,Q01968,Q9Y5X3,Q96J02,Q8IV08,Q9Y5X2,A4D1P6,Q9H223,P04439,Q15043 14 +Neuron projection membrane 0.446985031874301 0.6262880876875194 0.5311259983302568 1.0 0.6761814180423017 9 O94832,P20020 2 +Tertiary granule 0.3323631599934941 0.5974520034087262 0.5502056426607085 1.0 0.6985152642158995 41 Q13510,O15400,P13473,Q93050,P42785,Q4KMQ2,P17931,Q7L576,P11279,P10253 10 +Secretory vesicle 0.2833073074968951 0.5950637225802151 0.5518008768667351 1.0 0.6985891324120643 268 P35613,P30519,Q07065,P15289,Q13277,Q8NBX0,Q93050,P45880,P06280,P20020,P11279,Q13510,P42892,Q96RL7,P16278,Q9BVK6,Q9H7Z7,P42785,P0DP25,P50897,Q9NUQ9,O43681,P49755,Q99536,P61020,P09429,O15260,P13473,Q9NQX7,P07602,Q969Q5,O76024,O00264,Q9Y487,Q9UQB8,P10253,P05067,P17900,Q9BRF8,Q9BTY2,Q15907,P10619,Q15363,Q9NZJ7 44 +Apical plasma membrane 0.3305633066470435 0.5913992772697416 0.5542529245256307 1.0 0.7007175360136277 43 O75955,Q16625,Q13277,P53985,Q86UE4,P55011,Q99797,P20020,P08183,Q9Y6M7,P30825,Q15043 12 +Ribonuclease mrp complex 0.3845929384301227 0.5817748070954719 0.5607183755162377 1.0 0.7059459880114406 3 P78346,Q99575 2 +Sodium potassium exchanging atpase complex 0.3599766627771251 0.5714315348065898 0.5677071579300041 1.0 0.7100437225368292 2 P05023 1 +Cation transporting atpase complex 0.3599766627771251 0.5714315348065898 0.5677071579300041 1.0 0.7100437225368292 2 P05023 1 +Endoplasmic reticulum exit site 0.380227777508931 0.5654431873154337 0.5717723566010875 1.0 0.712950716255677 19 Q9Y6B6,Q9HCU5,Q9NR31,O95487,Q96PC5 5 +Schaffer collateral ca1 synapse 0.3962614718594915 0.5618973486061888 0.574185960262342 1.0 0.713300972555413 15 Q13277,Q9UQB8,Q00535 3 +Annulate lamellae 0.4198540145985436 0.5518072741126454 0.5810804030196395 1.0 0.7186787212554908 5 Q9Y5L0,Q8TD16,O14980,P63241 4 +Anchored component of synaptic membrane 0.352100350058345 0.5298241286583918 0.5962338743068112 1.0 0.7348183518956812 2 Q15334 1 +Meiotic spindle 0.3949933073178028 0.5201265615187074 0.602975366513445 1.0 0.7376912626658432 4 O14965 1 +Cytosolic region 0.4280597201136744 0.51320000695596 0.6078114210977774 1.0 0.7426083088412361 7 Q9UQB8 1 +Immunological synapse 0.4066492854173226 0.4903103003088005 0.6239143393547786 1.0 0.7551772762629744 12 P17931,Q9UJZ1,P20020 3 +Late endosome membrane 0.3276017492590131 0.4867379985348557 0.6264440134109328 1.0 0.7572308619555026 36 O15118,P13473,Q14849,Q8IV08,A4D1P6,Q14108,P11279,Q15043 8 +Pole plasm 0.4047989396737389 0.482375343868429 0.6295393331134185 1.0 0.758260271456691 5 Q9Y2W6,Q9HCE1 2 +Nucleoid 0.3314406763673816 0.4815314623696221 0.6301388242344095 1.0 0.758260271456691 33 P49748,P45880,P21796,P05141,Q9NVI7,Q96QE5 6 +Centriolar subdistal appendage 0.3644587102422052 0.4811922587522333 0.6303798622330099 1.0 0.758260271456691 3 O00139,Q14203 2 +Gpi anchor transamidase complex 0.4037884437110514 0.4777975400336396 0.6327943121999973 1.0 0.7588522820445878 5 Q92643,O43292 2 +Beta catenin destruction complex 0.381090647669746 0.4550715494588357 0.6490577652484126 1.0 0.7750238021067327 4 P48729 1 +Anaphase promoting complex 0.4075779517341472 0.4486767652197125 0.653664848054746 1.0 0.7787435738948415 10 Q9H1A4,Q9UJX4,Q9UJX3,Q16763,Q13042,P30260 6 +Peptidase complex 0.3036802278109858 0.4447202570300769 0.6565219283034933 1.0 0.7807840278071937 65 P67812,P60900,P28072,O43292,O43396,P61289,Q9Y6J9,P49721 8 +Platelet alpha granule lumen 0.3956304259887596 0.435285531912352 0.663355185305696 1.0 0.784774046984945 12 P05067,Q8NBX0 2 +External side of plasma membrane 0.3545379170892818 0.433455427694953 0.6646839405426106 1.0 0.784774046984945 20 P49327,P42892,P55899,P14735,P08183,O96005,P11279 7 +Copii vesicle coat 0.4017181035510742 0.4326773776024671 0.6652491668984077 1.0 0.784774046984945 11 Q9NR31,Q9Y3B3 2 +Early endosome 0.2939079183287904 0.4321485745427488 0.665633432591191 1.0 0.784774046984945 109 P42858,P01889,O75165,Q01968,Q9Y5X3,Q9UIQ6,Q8IV08,Q5VYK3,Q15043,P62820,O75955,Q13510,O15400,Q9Y5X2,Q5VW38,Q9H223,P04439,Q86Y82,Q5T9L3,P61020,A4D1P6,Q9BUN8,P05067,O94832,Q96J02,Q99523,Q92544 27 +Recycling endosome membrane 0.3432757808546517 0.429611188724572 0.6674784967259793 1.0 0.7859299916112891 24 O15127,P01889,P02786,Q7Z3C6,Q15907,Q9H223,P04439,Q86Y82 8 +Intrinsic component of presynaptic membrane 0.3917159167969545 0.4240035821908687 0.6715632008234746 1.0 0.7876786445787594 5 P20020,Q92542 2 +Protein kinase complex 0.3272504312483705 0.4162193140231351 0.6772495279824375 1.0 0.7933245115155099 29 P54646,O95067,P11802,P50750,P14635,P06493,P78527,Q00535,Q9P287,P54619 10 +Main axon 0.3909156675742419 0.4121846539034547 0.6802040843460357 1.0 0.7948069425771587 12 P05067,O94832,Q8IXJ6 3 +Organelle envelope lumen 0.3148910458367714 0.4093717263947048 0.6822668853535927 1.0 0.7948069425771587 38 P05067,Q9Y5J9,O14925,Q9Y5L4,Q96AY3,Q9H4A6,P51970,Q8IYU8 8 +9plus0 non motile cilium 0.3892737282383983 0.4042067991390256 0.6860606543609868 1.0 0.7967576065515081 12 P35613,P41208,Q15555 3 +Multivesicular body 0.3974997566471472 0.4018612325132148 0.6877861550288045 1.0 0.7974459373994685 10 P11279,Q9UBN7 2 +Dynein complex 0.3847562972000783 0.3824447500782491 0.702131502705132 1.0 0.8089195639530609 12 Q9UJW0,Q14204,Q13409,Q14203,Q13561 5 +Basolateral plasma membrane 0.3046204864168412 0.354565157063944 0.7229153829263419 1.0 0.8276102719711201 41 P35613,O75955,P57105,O94832,P53985,P55011,P14735,P20020,Q9Y6M7,P30825,Q15043 11 +Secretory granule 0.2706652911434836 0.3432077233926377 0.7314421947515544 1.0 0.8311537682132668 244 P35613,P30519,Q07065,P15289,Q13277,Q8NBX0,Q93050,P45880,P06280,P11279,Q13510,P42892,Q96RL7,P16278,Q9H7Z7,P42785,Q9NUQ9,O43681,P49755,Q99536,P61020,P09429,P13473,O15260,Q9NQX7,P07602,Q969Q5,O76024,O00264,Q9Y487,Q9UQB8,P10253,P05067,P17900,Q9BRF8,Q9BTY2,Q15363,P10619,Q9NZJ7 39 +Microbody lumen 0.3300779214453478 0.3431462150374907 0.7314884648741622 1.0 0.8311537682132668 24 Q15067,P14735,Q13315,O00116,A8MXV4 5 +Cytoplasmic dynein complex 0.3838264755482563 0.3404439328698015 0.7335222387222142 1.0 0.8321944586388198 10 Q9UJW0,Q13409 2 +Risc loading complex 0.3339586519186813 0.3394969757579796 0.7342353749486616 1.0 0.8321944586388198 3 O75569 1 +Platelet alpha granule 0.3482441627317614 0.3319874566565841 0.7398987305215092 1.0 0.8365272960746913 17 P05067,Q8NBX0 2 +Messenger ribonucleoprotein complex 0.3794010978423083 0.3012433850426647 0.7632289089224131 1.0 0.8533518797176796 6 Q99959 1 +Nuclear envelope 0.2590125618456632 0.2920196961296242 0.77027156466758 1.0 0.8570096111172952 180 P80303,Q8NFQ8,O15118,P41208,Q9H1E5,O76062,Q86UE4,P05067,Q9BTX1,Q96P70,O75844,Q96KC8,Q9H2V7,O15173,Q99720,Q9NQC3,Q8IXM6,Q5BJF2 18 +Endoplasmic reticulum lumen 0.2899671998582972 0.2873910036562768 0.7738129488395449 1.0 0.859897274443944 61 Q9NWM8,P15289,Q07065,P05067,Q02818,O95881,Q14257,Q9BTY2,Q96AY3,O76024,O43681,Q9NZ08,Q9Y680 13 +Ciliary basal body 0.3172034122833562 0.2622294183703403 0.7931445741580834 1.0 0.8760248091247846 24 Q15154,P41208,A0AVF1,P48729 4 +Myelin sheath 0.3576386070398814 0.2583911359042766 0.7961050569102575 1.0 0.8771630263411201 12 O94832,P04350,Q9NR77,P0DP25,Q8IXJ6 5 +Terminal bouton 0.3491368506293948 0.2504821638568298 0.8022144963400173 1.0 0.8828244275703097 5 Q7L576 1 +Mcrd mediated mrna stability complex 0.3486131386861361 0.2485345563881137 0.8037208364920079 1.0 0.8834126243908528 5 Q14103,P11940,O60506,Q9H074 4 +Cuticular plate 0.3116428362999806 0.2465169597113169 0.8052820775060225 1.0 0.8840596720446552 3 Q01082,Q12965 2 +Lumenal side of endoplasmic reticulum membrane 0.3567566232069012 0.2204788910362402 0.8254982104249675 1.0 0.8997336610027523 8 Q8TCT9,P04439,P01889 3 +Prefoldin complex 0.3207322068144217 0.2062482402732227 0.8365970074995066 1.0 0.9085623414779588 4 O15212 1 +Ap type membrane coat adaptor complex 0.3479089897053564 0.1974651961395774 0.8434635146514406 1.0 0.9149264138641522 11 O14617,Q9Y2T2,O00203 3 +Hops complex 0.3322627737226314 0.190393755672583 0.8490005904326106 1.0 0.9198349662732336 5 Q9P253,Q9H267,Q96AX1,Q9H269 4 +Non motile cilium 0.3156911257444912 0.167077771717176 0.8673088557606983 1.0 0.9363227433331054 17 P35613,Q15154,P41208,Q15555 4 +Specific granule 0.2871677767751461 0.1584308238600638 0.8741173265656452 1.0 0.9403226625422147 34 O00264,P30519,Q07065 3 +Mitochondrial alpha ketoglutarate dehydrogenase complex 0.3013486449021388 0.141640330507482 0.8873641089271731 1.0 0.950821440451785 4 O14874 1 +Outer kinetochore 0.3328365753027092 0.1384852351278743 0.8898569378419441 1.0 0.9516234782333262 7 P14635 1 +Cytoplasmic side of endoplasmic reticulum membrane 0.3308266506406052 0.1340439684124898 0.893367806374048 1.0 0.9542553889471324 6 Q8TCT9 1 +Mediator complex 0.3247928498946932 0.1269410675846622 0.8989870423105204 1.0 0.9580061212898746 12 P50750,O75448,P11802,Q9NVC6 4 +Cul4 ring e3 ubiquitin ligase complex 0.3273285822326356 0.1218243979510436 0.9030380910941124 1.0 0.9606993074138066 11 Q9NXF7,Q9Y4B6,P61962,Q66K64 4 +Filopodium tip 0.3259345794392592 0.119745272159823 0.9046849363544758 1.0 0.9606993074138066 6 P61086,O95782,Q8IZP0,Q06787,Q7L576 5 +Stereocilium membrane 0.2690399766559752 0.1017435894474451 0.9189602022720856 1.0 0.971536690779944 3 O00159,Q12965 2 +Microtubule associated complex 0.2696572156239544 0.1000924844929624 0.9202709018754072 1.0 0.971536690779944 53 Q9UJW0,O94927,Q13409,Q9UBN7,Q15555,Q96P70,P49354,P43034,O75935,P49356,O14965 11 +Cytosolic small ribosomal subunit 0.2798933461244823 0.098995622526418 0.9211417457502888 1.0 0.971536690779944 31 Q7Z478,P62847 2 +Proteasome complex 0.2716163890011815 0.0987922518587741 0.9213032205195948 1.0 0.971536690779944 49 P20618,P60900,P28072,P51665,O43242,O43396,P61289,P28074,P49721,Q92530,Q5VYK3,Q99436 12 +Centriole 0.2757854638463752 0.0863410140982463 0.9311953356538092 1.0 0.9808303129887748 35 Q15154,P41208,P42858,O95613,O95684 5 +Ctf18 rfc like complex 0.3131905797888591 0.0849171058971982 0.9323272923682152 1.0 0.980886005512393 6 P0CG13 1 +Pigment granule 0.2678375119382616 0.073150799589836 0.94168611767631 1.0 0.989586914413602 59 P35613,O75955,P62820,P61020,Q13277,P49327,P57088,P11166,Q93050,O43852,O14773,P27824,P61019,P55209,Q92820,P49755,P11279,Q92542 18 +Site of polarized growth 0.2664053960316985 0.0666763762212893 0.9468393414947176 1.0 0.9938533041786354 55 P05067,Q96N67,Q9UKA9,Q13277,O94915,P43034,Q00535,P0DP25,P50570,Q9BTU6,Q99720,Q7L576,Q8IXJ6 13 +Ubiquitin ligase complex 0.2634030739736478 0.0384757716738638 0.9693083485799756 1.0 1.0 74 Q9NXR7,Q96K76,O75150,P61088,Q9NWU2,P61962,P46934,Q93034,Q6NTF9,O75448,Q9BTE7,Q9NXF7,Q92564,Q96P70,Q9H1A4,Q9UJX4,Q9HB71,Q9H3F6,Q9UBU6,Q9BUN8,Q96GG9,Q16763,Q66K64,Q13438,P62699 25 +Neuromuscular junction 0.2818460192523824 0.02252375606527 0.9820301622055254 1.0 1.0 16 P57105 1 +Endoplasmic reticulum tubular network 0.2917555592503703 0.0209297714832965 0.983301677612778 1.0 1.0 12 Q8NHH9,P50402,Q15042,Q9NQC3 4 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f367718e29b615c0094dbce7e3812fc008b12bf1 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atp binding cassette abc transporter complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc 1 complex", "Bloc complex", "Blood microparticle", "Borc complex", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Calyx of held", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body fiber", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Checkpoint clamp complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition fiber", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fanconi anaemia nuclear complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fhf complex", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gemini of coiled bodies", "Germ cell nucleus", "Gid complex", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle a", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microfibril", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mks complex", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Mon1 ccz1 complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class i", "Phosphatidylinositol 3 kinase complex class ia", "Phosphatidylinositol 3 kinase complex class iii", "Photoreceptor connecting cilium", "Photoreceptor disc membrane", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilia coupling link", "Stereocilium bundle", "Stereocilium membrane", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic cleft", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAGAB", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADNP", "ADPGK", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR7A2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANKRD13A", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEH", "APEX1", "API5", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARL8B", "ARMC1", "ARMC10", "ARMC8", "ARMC9", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG3", "ATG7", "ATG9A", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATR", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT1", "BCAT2", "BCCIP", "BCKDHB", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BECN1", "BEND3", "BICD2", "BIRC6", "BLM", "BLOC1S1", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRD8", "BRI3BP", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C12orf73", "C19orf70", "C1QBP", "C1orf35", "C21orf59", "C2CD2L", "C2CD5", "C2orf49", "C3orf58", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARS2", "CASK", "CASP3", "CAST", "CBFB", "CBL", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC22", "CCDC47", "CCDC58", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CEP170", "CEP250", "CEP290", "CEP44", "CEP55", "CEP97", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTF8", "CHUK", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIT", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT4", "CNOT7", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG5", "COG7", "COG8", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTDP1", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTC", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF15", "DCAF16", "DCAF7", "DCP1A", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF2", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DSC2", "DSE", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUS2", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOG", "ENO1", "ENO2", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM105A", "FAM126A", "FAM129B", "FAM162A", "FAM208A", "FAM20B", "FAM49B", "FAM83D", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXL18", "FBXO22", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FLYWCH1", "FMR1", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN6", "GET4", "GFM1", "GGA1", "GGA2", "GGCX", "GGH", "GHDC", "GHITM", "GID8", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNG5", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSR", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP8", "GTSE1", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDGF", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEBP2", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HOOK1", "HP1BP3", "HPF1", "HPS5", "HS1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS4", "INTS6", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "ISCA2", "ISG20L2", "ISOC1", "IST1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPK1", "ITSN2", "IVD", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA1468", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT4", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8A", "LRWD1", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCRS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METTL13", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD10", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOCS2", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDZ", "MPHOSPH10", "MPHOSPH6", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL50", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAF1", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NENF", "NES", "NEU1", "NF1", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NLE1", "NLN", "NMD3", "NME1", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C3A", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT19", "NUDT21", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTULIN", "OXA1L", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAWR", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCNT", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEF1", "PELP1", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF6", "PHIP", "PHLDB2", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN4", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLEKHA7", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "POMP", "PON2", "POP1", "POR", "POU2F1", "PPA2", "PPAN", "PPFIA1", "PPFIBP1", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PRUNE1", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTPA", "PTPN1", "PTPN23", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REL", "RELA", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SACS", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SC5D", "SCAF1", "SCAF11", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SCYL1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3RF1", "SHCBP1", "SHMT2", "SHPRH", "SHTN1", "SIGMAR1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKA3", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35A4", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLFN11", "SLIRP", "SLK", "SLMAP", "SLTM", "SLU7", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRA1", "SRCAP", "SREK1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR3", "SSR4", "SSRP1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAMM41", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TCP11L1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TENM3", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TM7SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM33", "TMEM43", "TMEM87A", "TMEM97", "TMLHE", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP1", "TPBG", "TPD52", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC13", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM27", "TRIM28", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TST", "TTC1", "TTC19", "TTC26", "TTC28", "TTC37", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA5", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UFD1", "UFL1", "UGGT1", "UHRF1", "ULK3", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP28", "USP32", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS28", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VPS72", "VRK1", "VRK2", "VRK3", "WAPL", "WASF2", "WASHC3", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR35", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR47", "WDR48", "WDR5", "WDR61", "WDR62", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WLS", "WRAP53", "WRAP73", "WTAP", "WWP2", "XAB2", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO6", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YES1", "YKT6", "YLPM1", "YME1L1", "YPEL5", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCCHC11", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMAT2", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF326", "ZNF622", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB8", "ABCD4", "ABHD10", "ABI1", "ACADVL", "ACAP2", "ACOX1", "ACOX3", "ACP2", "ACP6", "ADPGK", "AGPAT5", "AGPS", "AHCYL1", "AKAP10", "ALDH1A2", "ALDH3A2", "ALG1", "ALG11", "ALKBH5", "ANAPC1", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD13A", "ANO6", "AP2A1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APOL2", "APOO", "APOOL", "APP", "ARF4", "ARFIP1", "ARHGEF2", "ARL6IP1", "ARSA", "ASAH1", "ASNA1", "ATAD3A", "ATG9A", "ATL2", "ATM", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATR", "AURKA", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BAX", "BCAS3", "BCCIP", "BCKDK", "BCL2L13", "BECN1", "BICD2", "BRCA1", "BRI3BP", "BSG", "C12orf73", "C19orf70", "CACYBP", "CALM3", "CALU", "CAMK2G", "CANX", "CASP3", "CCDC47", "CCNB1", "CCNB2", "CD109", "CDC16", "CDC27", "CDK1", "CDK4", "CDK5", "CDK5RAP2", "CDK9", "CERS1", "CERS2", "CETN2", "CHRAC1", "CHTF8", "CISD1", "CKAP4", "CLCN7", "CLN5", "CLPP", "CLPTM1", "COA3", "COG5", "COG7", "COG8", "COPG1", "COPS4", "COX15", "COX2", "COX4I1", "COX6B1", "COX7A2", "CPPED1", "CPT2", "CSE1L", "CSNK1A1", "CTSA", "CUL5", "CYB5B", "CYFIP1", "CYP51A1", "DAGLB", "DCAF1", "DCAF15", "DCAF16", "DCAF7", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DDB1", "DDRGK1", "DDX31", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX29", "DHX36", "DNAJB6", "DNAJC1", "DNAJC13", "DNM2", "DOCK7", "DOLPP1", "DSE", "DTL", "DYNC1H1", "DYNC1I2", "ECE1", "EEF1D", "EHD4", "EIF2S1", "EIF2S2", "EIF5A", "EMC7", "EMD", "EPDR1", "EPHX1", "ERAP1", "ERGIC3", "ETFDH", "EXOC2", "EXOC3", "EXOC7", "FADS2", "FAM162A", "FAM20B", "FAM49B", "FAM8A1", "FAM91A1", 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transmembrane transporter activity 35 71 3.514847518099686 0.0004400065524319 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 0.0141292836774146 0.0308143020622331 0.0023050420516563 8.49740324187542e-05 2.39952893371316e-06 +Cation transmembrane transporter activity 34 65 3.448689315153934 0.0005633144348766 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 0.5645793526399844 0.6829262542482903 0.0715157250646603 0.0001542585439863 7.43702574580328e-06 +Lipid binding 29 156 3.38442681793519 0.0007132703024061 30.883495145631063 138.65533980582524 0.9844637598707308 0.4289871747751645 8.92748670410201 14.760635317682617 1.446857667744565 0.4068298387995807 0.0002585511920742 0.0013982202745197 0.0003462915456642 0.0013159384462046 0.0195864357597532 +Active transmembrane transporter activity 31 74 3.367737211283232 0.0007578779753985 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 0.0822972595345236 0.6332097195283641 0.0130891925218009 3.115772874042807e-05 4.1036289666354474e-08 +Steroid binding 9 23 3.348808652212912 0.0008115982593801 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 2.562487711591701e-06 3.745017516645138e-06 6.76794881948827e-06 2.078573381251053e-07 1.7824094846844216e-05 +Tetrapyrrole binding 9 18 3.330809067303828 0.0008659397526886 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.0009475018323456 0.0023085518548632 0.0017566671607845 5.100580211902312e-06 0.0002385246399813 +Anion transmembrane transporter activity 24 43 3.275719054243827 0.0010539334608055 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 0.003582430265017 0.0033011735408768 0.0072395357132445 0.0034907253987009 1.02793849599523e-05 +Serine hydrolase activity 6 18 3.1977044902846967 0.0013852615604545 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 4.1183264776790406e-05 8.494254101186968e-05 9.137815410524424e-05 0.0001418153943193 0.0081332818022798 +Molecular transducer activity 8 34 3.1256230310984163 0.0017742883406675 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.0589652879423998 0.1323708772076377 0.1025723617341366 0.1746659339951793 0.8144012927760322 +Serine type carboxypeptidase activity 3 5 3.0827371182693506 0.00205106253949 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 5.1414797307057535e-06 0.0002334823336694 8.49211205937994e-06 1.649417533450067e-06 2.682481879206317e-05 +Active ion transmembrane transporter activity 19 38 3.0734904523381386 0.0021157045764941 16.271844660194176 41.71116504854369 1.2957221273899948 0.3267733012969381 7.788084220174416 5.097264791179653 1.6571109350293016 0.3632481416270505 0.6209562593926423 1.0 0.3139585525038253 0.0022388598446307 5.436205328755033e-05 +Sterol transfer activity 1 5 3.0687456848797146 0.0021495949553005 1.1213592233009708 3.344660194174758 0.3235272874601829 0.3390492486761095 0.8729094844518525 0.949013607004438 1.3678558444912603 0.2777240845045601 0.0034334205639732 0.0012601973854463 0.0047533286028597 0.027832231049335 0.0974859568290139 +Ceramide binding 4 5 3.011557321812574 0.002599113248962 2.8228155339805827 5.048543689320389 1.42330045764979 0.1242195400491618 1.17628831869178 0.9309003969609838 1.481980135982154 0.2133994029014766 2.7606668988593696e-06 3.066034551708988e-05 5.369271916582234e-06 8.796898694645245e-06 0.0002504856541451 +Sterol binding 5 18 3.003532314052692 0.0026686520743144 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 9.78792173649192e-06 7.767065221647448e-07 2.2037872854000083e-05 0.0002012784147989 0.0015247609081843 +Proton transmembrane transporter activity 12 35 2.9486251223470497 0.0031919090104075 12.769417475728156 35.478155339805824 1.2352045534927034 0.2879171268332734 5.319202861157036 2.7149368379617917 1.7021108079122016 0.3308025072902738 0.1216592602205618 0.3058671484100957 0.0055234944679999 1.8136205386528244e-07 3.897270991547889e-07 +Serine type exopeptidase activity 4 7 2.9313986224633406 0.0033743948208 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 4.218158680727945e-05 0.0008300469730069 6.936272072908627e-05 9.327097249989188e-07 2.8870402872731e-05 +Phosphatidylcholine binding 2 7 2.89077523988264 0.0038429285260153 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.0002698581237979 5.941460259222129e-05 0.000440337804097 0.0062267265321947 0.0401461367370898 +Endopeptidase activity 23 65 2.887098417017836 0.0038881259047331 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 0.0462341618392982 0.1955208267630179 0.0756746726427118 0.0071073575953651 0.0011994014780138 +Organic anion transmembrane transporter activity 15 28 2.8697849847524566 0.0041075100400296 12.951456310679612 30.182038834951456 1.56101282472555 0.2452312368187786 6.880574373146614 3.5222410835885483 1.575669523214114 0.314839840161206 0.152104590180354 0.3426841548479852 0.1967082241040804 0.0169357854376417 0.0026801846148119 +Cholesterol binding 5 15 2.853948789551307 0.004317949113467 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 3.844299215616099e-06 3.001636272447584e-07 8.719376349895246e-06 6.929711507029932e-05 0.0004790727366591 +Galactosyltransferase activity 2 5 2.8478917215904267 0.0044009895369048 1.4004854368932038 4.014563106796117 0.4835514024572315 0.4297894898723106 1.1026445515529784 1.0725079733100582 1.0886375545888918 0.3129067636178667 1.0 1.0 1.0 0.0062267265321947 0.0401461367370898 +Alcohol binding 5 17 2.8343755393806824 0.0045915339399056 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 5.031408806994049e-05 4.145834874720293e-06 0.0001113664394611 0.0012377122057681 0.0101516407294213 +Hydrolase activity acting on glycosyl bonds 9 30 2.811704094766979 0.0049279815554272 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 0.0215059099610276 0.3024216363859021 0.033011066423499 0.0018794473463126 0.0027070136406106 +Protein transporter activity 8 15 2.788618849992371 0.0052933321207131 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 4.533849025767395e-05 0.0065792573185243 8.694316847855437e-05 2.2879176712764704e-05 1.4660824937382194e-06 +G protein alpha subunit binding 1 5 2.787450580228761 0.0053124556474795 1.2815533980582523 3.96116504854369 1.1518090627532231 0.2356662931606298 0.7653601947652959 0.7780025469432862 1.0915303524696884 0.2503004448344019 0.0072960555134274 0.0027067874988798 0.0100519320580488 0.0561137872346343 0.1818418904091173 +Vitamin transmembrane transporter activity 3 5 2.781293038275392 0.0054142840504298 2.7766990291262137 6.252427184466019 1.4438342367310928 0.182339474606115 1.52603324115363 1.3650879028699858 1.0282691527982806 0.2346378729908682 0.1439609493286736 1.0 0.1677870330809631 0.0009779431698101 0.0120515986398723 +Amide binding 23 110 2.755104144030706 0.0058673456231379 22.521844660194176 102.53398058252426 0.8716704131409604 0.4134472412494542 7.596116055031058 7.786365397071367 1.2519470693533183 0.3815633057547212 7.930934838427674e-07 0.0032478194797668 5.943698306786224e-07 1.5050965614820188e-10 4.6716254013133495e-09 +Secondary active transmembrane transporter activity 11 19 2.7149493725592317 0.0066285902915623 9.080097087378642 21.490291262135923 1.2627683473613005 0.2947710034053126 5.466215032972134 3.0675886156990426 1.4241587428281404 0.3340388164945335 0.1606544482804305 1.0 0.2072288126229632 0.0621642703962852 0.01028970028679 +Monooxygenase activity 5 10 2.7067442169604123 0.0067946586084868 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0201433177792313 0.0076498462283805 0.0274603336438859 0.0004179970223822 0.0016034677277021 +Glycolipid binding 5 9 2.695245478607714 0.0070336791140004 3.95873786407767 9.17233009708738 1.1300394975336625 0.1723818604496332 1.779261971800237 1.789101691327159 1.517965150696512 0.2390589148665743 0.000325764016582 0.0802348466038066 0.0005309775927247 1.8818469985730976e-06 0.0001016217979366 +Hydrolase activity hydrolyzing o glycosyl compounds 8 23 2.6877848847030688 0.0071927717174355 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 0.0069121244314848 0.2106238865633207 0.0108939889611676 0.0009951056419778 0.0004418539826712 +Sphingolipid binding 5 7 2.6831929349782104 0.0072922907344876 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 1.1453789936630002e-05 8.597904339497348e-05 2.214575962840231e-05 5.302129833761715e-05 0.0001461959825676 +Peptidase activity 32 117 2.633253258997587 0.0084571259483139 29.021844660194176 113.626213592233 1.2572335980018865 0.3731282983707893 8.334453494010912 9.805689463637474 1.5136028692995414 0.3922229485757941 0.0095434922248472 0.0542732260417351 0.0222030587712471 0.0019759955585733 0.0043697516464878 +Primary active transmembrane transporter activity 20 56 2.617684193194098 0.00885286950304 17.696601941747574 52.529126213592235 1.0080198242353189 0.3544097082146772 7.649017203625277 6.455721193615876 1.66885648871365 0.3767837436492733 0.2556169370591458 0.4475497772550058 0.028278569718715 0.0001527751802754 2.844337499882519e-07 +Lipid transporter activity 12 23 2.615097203696408 0.0089202065295559 6.546116504854369 19.805825242718445 0.7389006587243017 0.301332987440896 3.074370954053146 3.741159812966952 1.4134673193588587 0.2984913911167897 0.1298049423458981 0.0546342218360011 0.1690424872723929 0.0386631533679294 0.0333177078736064 +Palmitoyl protein hydrolase activity 1 5 2.594866038045677 0.0094627793150925 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0040983965897468 1.0 0.0056684159955205 0.0328731354880699 0.113339965404402 +Sterol transporter activity 3 10 2.589943009473786 0.00959918221429 2.621359223300971 8.364077669902912 0.5454888897585024 0.2973249899153176 1.425267849835305 1.6080715320593837 1.318674977748992 0.2709274408896192 0.0148267428903527 0.0055832614279084 0.0202898922491691 0.0173886328284286 0.0236194052560011 +Macromolecule transmembrane transporter activity 6 13 2.5766564312596985 0.0099761053577105 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 1.7911542241865245e-05 0.0042324529563037 3.4550328168080166e-05 9.22092773458021e-05 2.789873905099777e-05 +Quaternary ammonium group binding 3 11 2.5665191099936613 0.0102724964730953 2.8567961165048543 12.12864077669903 0.9707568143407772 0.2573327609820879 1.4849985868988949 1.260087490061347 1.304146106648176 0.2795917987269193 0.0007164091674755 0.0001600370606554 0.0011613234829685 0.0017432511761074 0.020271757680103 +Atp dependent peptidase activity 0 5 2.553335696075432 0.0106696605568781 1.91747572815534 5.179611650485437 0.3096816660551942 0.4263179137334537 1.572823025272822 0.3901354565114186 1.104598172623402 0.3112103230891728 0.0556262242335954 0.0338360956076009 0.0653907127050202 0.1577810442013011 0.295251642909297 +Atp transmembrane transporter activity 3 5 2.54493294361352 0.0109298725188125 3.058252427184466 5.456310679611651 0.5680189081478334 0.3318090311699867 1.598392655736251 0.6936144116307477 1.3025695117924114 0.3140848719976767 1.0 1.0 1.0 0.0148625463558957 0.0003337445501144 +Protein transmembrane transporter activity 6 12 2.5403989471939954 0.0110726085965673 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 8.963957464742468e-06 0.0030581061915538 1.7352123755419733e-05 3.906142953800441e-05 7.955277431518348e-06 +Hexosaminidase activity 2 5 2.4833845246564605 0.0130140521252419 2.5194174757281553 4.973300970873787 0.3568105957806153 0.2227497456156347 1.091499214132507 0.3065083294438748 1.6445593916296413 0.2548912926080147 1.0 1.0 1.0 0.0010588751859522 0.0077568745967145 +Cysteine type endopeptidase regulator activity involved in apoptotic process 2 6 2.476843882508766 0.0132549866523572 2.487864077669903 6.155339805825243 -0.5976261422345511 0.4158756304167604 1.3714666166386429 0.6683886078726529 0.9732025376808128 0.2957325729934952 0.1647372735136017 0.1026081339138497 0.018640880521655 0.0153906222854723 0.0892170338783466 +Voltage gated anion channel activity 3 6 2.428657055073318 0.0151548597468536 2.854368932038835 6.25 1.127126362633441 0.1649553590552043 1.5417035527207152 0.9966570336472054 1.4583344406160936 0.2334940994157564 0.0028240506634377 0.0010343090391069 0.0039135152062846 0.0231366382468947 0.0009257875785001 +Exopeptidase activity 7 32 2.4272875642293603 0.0152121928724411 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 0.0014975426414666 0.0358926009784828 0.0027541417385927 0.0001028265848382 0.0001505378016183 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 14 34 2.4219530265395206 0.0154373458671759 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.1750936134432409 0.0760657989123155 0.2248900268904883 0.0750173773780456 0.0148600283171556 +Nucleobase containing compound transmembrane transporter activity 7 12 2.4030511536143573 0.0162589128954366 6.529126213592233 14.04126213592233 1.4296604886183193 0.212054291115069 3.2696940585469636 1.915888183904924 1.3255809572534116 0.2748813593420038 0.230458544012733 0.1457663642848915 0.266209970857853 0.0009447024772989 0.0007278251765531 +Lipid transfer activity 1 8 2.394510880714297 0.0166425496498325 1.966019417475728 6.618932038834951 0.4006158968389467 0.3501200832710581 1.370213887212628 1.5743486325272755 1.2182069511780798 0.2776659407244052 0.0261335387625208 0.0100088432903632 0.0354914601129098 0.1724444479617574 0.450369534817547 +Nucleotide transmembrane transporter activity 6 10 2.3729956245865504 0.0176444729371501 5.606796116504855 12.029126213592232 1.4217258291760082 0.2036087501116975 3.0234925518113496 1.8899648667798992 1.291115513359647 0.2666064512499804 0.157867792113085 0.0981765691424607 0.1837383274168749 0.0001186481206876 4.010191317578068e-05 +Organophosphate ester transmembrane transporter activity 6 10 2.3729956245865504 0.0176444729371501 5.665048543689321 12.143203883495143 1.4298365636921646 0.2056324024803549 3.029697948284232 1.927415248708952 1.2819429632405106 0.2680490563295835 0.1647372735136017 0.1026081339138497 0.191600110602388 0.0001505310959671 5.636361715141554e-05 +Oxidoreductase activity acting on a heme group of donors 4 7 2.371583687348735 0.0177120350857167 3.111650485436894 6.483009708737864 0.8850005512180296 0.2757097651603665 1.538237610319269 1.0226572421183926 1.2777814224392188 0.2966482201944345 1.0 1.0 1.0 0.0498779046475234 0.0005388274165263 +Glucosidase activity 1 5 2.3211685431682345 0.0202777492174042 1.674757281553398 4.980582524271845 0.3871275652038076 0.3636983138593921 1.1787123504763262 0.1379870912966203 1.1856385826834483 0.2919762169358068 0.0556262242335954 1.0 0.0653907127050202 0.1577810442013011 0.0423042030727838 +Peptide binding 15 80 2.310205700330303 0.0208767686141988 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 0.0012294766344115 0.1621145077252613 0.0028752871023592 4.986166093179258e-07 2.8671760276026736e-05 +Antiporter activity 5 8 2.3052386613900206 0.0211532107200118 4.621359223300971 10.405339805825244 1.056576117278179 0.2813324268221227 2.679901841610502 1.304685592846984 1.2558310293487471 0.3063102364368053 0.2733967462722031 1.0 0.3143397790261298 0.0142235096743441 0.010788368915323 +Peptide antigen binding 4 8 2.266627599676323 0.0234129846046395 2.25 5.218446601941747 1.3488418251083294 0.2076946662826 1.4985834735457568 1.269832767279765 0.9581301458127084 0.2397273125927817 0.0064177808396821 0.0711332726649859 0.0088504827764808 0.0051503840765812 0.0338099842169397 +Inorganic anion transmembrane transporter activity 8 19 2.260285531739361 0.0238035353507044 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.0008211635363398 0.002071073147083 0.0015259573241502 0.0367529115341812 0.0008152365052425 +Atpase coupled transmembrane transporter activity 12 24 2.248713315676257 0.0245307414568698 8.072815533980583 22.696601941747577 0.8561067713091313 0.3392846662603397 4.166386392056555 3.892074110340729 1.3163009809214623 0.3229730128136945 0.3783722246380302 1.0 0.4297892617739207 0.0515621560092188 0.0004366653435552 +Cyclin dependent protein serine threonine kinase regulator activity 3 5 2.2394846559789023 0.0251243985960358 2.4805825242718447 5.519417475728155 0.228341462053297 0.5714132507541911 1.69582916411688 1.600094551358398 0.8688933058851026 0.3181784185621054 1.0 1.0 1.0 1.0 0.5591798689697555 +Abc type transporter activity 5 10 2.210206561996524 0.0270908297741394 3.0194174757281553 7.652912621359223 0.9831250219385844 0.2361571806590424 1.9482657586917436 2.350049836723345 1.2743804993059251 0.258194993176919 0.1850152793775121 1.0 0.2147385524083838 0.0028478177309091 0.0010422272070108 +Cargo receptor activity 3 7 2.2009627827618496 0.0277386586765644 3.7063106796116503 7.95873786407767 0.9623237890522576 0.1578680760704802 1.9530058934839476 1.7914972745396005 1.6202205206532496 0.203966946010782 0.0215796251678188 0.1287528218161406 0.0293903981750984 0.1467432355955838 0.0451666412494461 +Carbohydrate derivative transmembrane transporter activity 5 9 2.177580173956692 0.0294373069125417 4.672330097087379 10.12135922330097 1.0096229459917263 0.2944050311743799 2.686158589641687 1.471354338494036 1.2935479322863277 0.3146313980204608 0.191665926491972 0.1201219647894398 0.2223047329091382 0.0242110622206542 0.0075753503172145 +Palmitoyltransferase activity 2 5 2.172718313954127 0.0298015245397069 1.8786407766990292 5.084951456310679 0.875863834441912 0.3421870647647222 1.2306088543936362 0.6827036113457149 1.018188317250868 0.2997914787323893 0.1439609493286736 1.0 0.1677870330809631 0.3727200206787977 0.236286730772413 +Dynactin binding 2 5 2.162215146365829 0.0306015965986392 2.150485436893204 5.584951456310679 0.2775355704886244 0.5227141328346228 1.318897287741983 1.161713977954793 0.9194793023459098 0.3062784805257165 1.0 1.0 1.0 1.0 0.0823369674942117 +Purine nucleotide transmembrane transporter activity 4 8 2.1324583495982345 0.0329691849861324 4.334951456310679 9.441747572815531 0.9917737457277228 0.2833655940290197 2.4104227054611673 1.6217588601139772 1.262135146193827 0.3001583617421954 0.1226742139485862 0.0756950383436983 0.1432798584585485 0.0062267265321947 0.0007525839576665 +Cullin family protein binding 2 6 2.1302148296960053 0.0331538812866973 1.8300970873786409 5.121359223300971 0.3673698119768558 0.502173694899352 1.3671836938429172 1.2147276242251626 0.9625644716440604 0.3225012539188705 0.1647372735136017 0.1026081339138497 0.191600110602388 0.4172977923286156 0.2914565107291916 +Antigen binding 4 10 2.1121900731485352 0.0346701496255177 2.504854368932039 6.936893203883495 1.1926555941065955 0.2669458193807861 1.6287691845260013 1.3674077446215156 0.9067202373946956 0.2605304200525402 0.0148267428903527 0.1070183553885475 0.0202898922491691 0.0173886328284286 0.09905667817091 +Snap receptor activity 7 10 2.1025573505229724 0.0355044814201206 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 1.0 1.0 1.0 0.5661975770404395 0.0816645346360282 +Anion channel activity 4 11 2.0979570938998644 0.0359089357495727 4.20873786407767 11.21116504854369 1.03959259790327 0.2192420598609839 2.3076742714116403 2.0905640066649145 1.3937691950814175 0.2662450395835827 0.0014713217280779 0.0003334624710947 0.0023694947377154 0.0294507732567689 0.010448798153629 +Organic acid transmembrane transporter activity 8 19 2.089429393353357 0.0366690876118622 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 0.427451384124797 1.0 0.4825947600252522 0.2274506769816413 0.0468956043941571 +Oxidoreductase activity 48 243 2.0882106971513217 0.0367788327930893 52.54126213592233 227.42961165048544 0.490492706528076 0.5955656171597654 20.033606385640603 16.688970744458114 1.2909283370539455 0.4039853598071011 0.0051076191125326 0.0080990643912862 0.0019611074592371 4.489282638554995e-07 4.092848197237384e-09 +Glycosyltransferase activity 16 51 2.0880396648350974 0.0367942568401364 10.808252427184469 46.75 0.6230735361107147 0.5000303532444054 4.489970468729936 5.6981622825309435 0.9932734853426128 0.358363386747457 0.3723918584085505 1.0 0.4537870647761208 0.0394842162502369 0.0877828739424634 +Amyloid beta binding 3 12 2.0320028267107717 0.0421533697832725 3.5898058252427183 10.560679611650484 1.053866189591651 0.2544642672774957 2.009490338022764 1.9342863324228672 1.0942484681219342 0.2534200432416059 0.2613762066892051 1.0 0.3009165941166509 0.0118572988629309 0.1040239469578102 +Nadph binding 1 5 2.029773997607717 0.0423795172023515 1.3786407766990292 5.429611650485437 0.8367704566864596 0.3914568233833007 1.0938176207501296 1.2950229014206938 0.8806674554162238 0.2962147259816868 0.1081933924999157 1.0 0.1265462710440741 0.290751966651369 0.1467539296032722 +Phospholipid binding 13 104 2.0271881967630425 0.042643169789245 18.890776699029125 88.4635922330097 0.777309720287493 0.452120200534915 6.970479526806733 10.51702894240924 1.1988133109990275 0.3785217149858343 0.0113511974176816 0.0599945491514207 0.0084671328775968 0.0636016933799903 0.3043491097243462 +Pre mirna binding 3 5 2.019240856764468 0.0434621917009891 2.395631067961165 4.645631067961165 0.0451174645519511 0.5714751002964188 1.4112173151187923 0.7699800399668832 0.8626355963307901 0.3053316374984833 1.0 1.0 1.0 1.0 0.2591162943571684 +Quinone binding 2 5 2.018670643134078 0.0435214632025469 2.0825242718446604 5.371359223300971 0.6144040024425256 0.3400691378536611 1.308295206174148 0.7946759106689059 1.1785397932704846 0.300626350021166 1.0 1.0 1.0 0.2731207001200411 0.1297945989547683 +Passive transmembrane transporter activity 14 33 2.0162927905568053 0.0437693683523858 10.728155339805824 34.00242718446602 0.8598494327527568 0.3171523987434088 5.464704354730218 4.259483301090722 1.5882390061019254 0.3339692919660049 0.0138460200078838 0.0022975434079307 0.0239832744272861 0.1429687098473413 0.0229956600929944 +Metalloendopeptidase activity 4 14 2.006796175378442 0.0447713702827092 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 0.2367426782920286 1.0 0.2732850813359189 0.0449350347407693 0.0206839034685982 +Tap binding 3 6 2.004856155328319 0.0449784271353068 1.8592233009708736 3.895631067961165 0.8127354819395453 0.3477955376218754 1.070154411615344 1.0456940556701602 1.051123567423606 0.2887299843781864 0.0556262242335954 1.0 0.0653907127050202 0.0113265963942617 0.0423042030727838 +Transferase activity transferring alkyl or aryl other than methyl groups 6 25 2.002403071274064 0.04524139843488 6.269417475728155 21.9004854368932 0.1637295171124019 0.5810042550406141 3.4221915209842564 3.50274507569733 0.8797870134307709 0.3068689904123456 1.0 1.0 1.0 0.0036383017284534 0.0043866153154496 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..51ca3ebee17ac35a09c2edee5191b8cf780f8fc2 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 1395, + "title": "Average number of proteins per term", + "value": 17.585663082437275 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..795af0fb60e97a6e7b69e9598917af81d5fec0a1 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..830b9d83a737c98066bfde6291d547a589989e35 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,429 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transporter activity 0.6281125083044619 5.68912431511688 1.2769248660942864e-08 1.781294334478091e-05 1.7813101883410295e-05 173 Q9NS69,P53985,L0R6Q1,Q9H9B4,P45880,P30536,Q07820,P21796,O43676,O60830,P06576,O75964,Q9UM00,Q8TB61,Q14849,Q9C0H2,Q9UBX3,Q96GC9,Q99595,Q96ES6,Q9Y584,P04062,Q8WTV0,P03886,Q03518,Q9UDW1,Q9Y487,Q70HW3,O15118,P17900,O15173,Q9H2D1,O14925,Q13423,Q93050,Q9HD20,P38435,Q9H2V7,Q9P0J0,O43772,O95202,Q9BSK2,P13073,Q8IXU6,P24539,P12235,P47985,Q03519,P00403,P12236,P30825,O14678,Q6P4A7,P16615,Q7KZN9,Q9Y619,P20020,Q9Y277,P49755,Q9BXW6,P51798,Q96NB2,Q15388,Q07812,Q99797,Q8NE01,Q9NUT2,P55011,P14854,Q9BQT8,Q15043,Q9Y5J9,Q8NE86,P08183,O43681,P56385,Q7Z3C6,Q9Y6M9,P51970,O43808,P05141 81 +Ion transmembrane transporter activity 0.6128739991592803 3.970418312721257 7.174655226904747e-05 0.0952440417287134 0.0032610339204676 95 P53985,Q13423,Q93050,Q9HD20,Q9Y619,P55011,Q9H9B4,P45880,P14854,P21796,Q9BQT8,P20020,O43772,O95202,P06576,Q15043,O75964,Q9UM00,Q9Y277,Q8NE86,Q8TB61,Q9C0H2,Q9UBX3,P13073,Q14728,P24539,Q96ES6,P12235,O43681,P47985,P56385,Q00535,Q4KMQ2,P51798,P00403,P12236,Q9UDW1,Q9Y6M7,Q9Y487,P30825,Q96NB2,Q70HW3,P11166,O43808,P05141,Q6P4A7,Q9H2D1,P16615,Q7KZN9 49 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9953325554259038 3.893479058401399 9.881673655409706e-05 0.1287759994071763 0.0032610339204676 2 P30519 1 +Er retention sequence binding 0.9830805134189012 3.839603174610217 0.0001232333337377 0.1579543869903108 0.0033346525429886 2 P24390 1 +Sulfatide binding 0.9682030338389712 3.7736936721546854 0.0001608482443657 0.2010056053167053 0.0038031067947506 2 P50897 1 +Lysophosphatidic acid binding 0.9682030338389712 3.7736936721546854 0.0001608482443657 0.2010056053167053 0.0038031067947506 2 P50897 1 +Vitamin d binding 0.9579929988331364 3.728146421317766 0.0001928933010186 0.2359424081982708 0.0040770629533494 2 P04062 1 +Sulfotransferase activity 0.9492415402567094 3.6888986897747498 0.0002252268750027 0.2696466918289653 0.004425232262377 2 Q06520 1 +Ribosomal protein s6 kinase activity 0.9364060676779402 3.6309845452341096 0.0002823420932578 0.3255939040142542 0.0047643552094154 2 P51812 1 +Sphingosine n acyltransferase activity 0.9299883313885592 3.6018691342121043 0.0003159374067476 0.3564800943741708 0.0048839023204445 2 Q96G23 1 +Catalytic activity acting on a glycoprotein 0.9285297549591596 3.5952371421751956 0.0003240962197939 0.3637651397605693 0.0048839023204445 2 Q96L58 1 +Beta 1 3 galactosyltransferase activity 0.9285297549591596 3.5952371421751956 0.0003240962197939 0.3637651397605693 0.0048839023204445 2 Q96L58 1 +Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity 0.9285297549591596 3.5952371421751956 0.0003240962197939 0.3637651397605693 0.0048839023204445 2 Q96L58 1 +L ornithine transmembrane transporter activity 0.9226954492415408 3.568653837497553 0.0003588201422881 0.3938597744761052 0.0048839023204445 2 P30825 1 +5 3 exodeoxyribonuclease activity 0.9209451575262482 3.560661514009175 0.0003699216888515 0.403177916042562 0.0048839023204445 2 Q9UQ84 1 +Phospholipase d activity 0.9209451575262466 3.560661514009175 0.0003699216888515 0.403177916042562 0.0048839023204445 2 P09601 1 +Inorganic molecular entity transmembrane transporter activity 0.5919491993962813 3.514847518099686 0.0004400065524319 0.4587880055785641 0.0054345446148305 71 Q13423,Q93050,Q9HD20,P55011,P14854,P45880,P21796,P20020,O95202,P06576,Q15043,O75964,Q9UM00,Q9Y277,Q8NE86,Q9C0H2,P13073,Q9UBX3,O43681,P24539,P12235,Q96ES6,P47985,P56385,Q00535,Q4KMQ2,P51798,P00403,Q9UDW1,Q9Y487,Q9Y6M7,P05141,Q99797,P16615,Q7KZN9 35 +Cation transmembrane transporter activity 0.601398211194097 3.448689315153934 0.0005633144348766 0.5443567183579876 0.0063479633502727 65 Q13423,Q93050,Q9HD20,Q9Y619,P14854,Q9H9B4,P55011,P20020,O43772,O95202,P06576,Q15043,O75964,Q9UM00,Q8NE86,P13073,P24539,Q96ES6,P12235,P47985,P56385,Q00535,Q4KMQ2,P00403,Q96NB2,Q9Y487,P30825,Q9UDW1,Q9Y6M7,Q70HW3,O43808,P05141,P16615,Q7KZN9 34 +Galactoside binding 0.8841890315052399 3.3909394348311492 0.0006965349178305 0.6216761739053909 0.0071975274842485 2 P16278 1 +Galactosidase activity 0.8841890315052399 3.3909394348311492 0.0006965349178305 0.6216761739053909 0.0071975274842485 2 P16278 1 +Lipid binding 0.4724935984363686 3.38442681793519 0.0007132703024061 0.6304122549019731 0.0072474814788127 156 Q13277,P30536,P45880,Q9BQE5,A6NIH7,Q9Y5X3,P38435,Q9H4A6,P21796,Q14108,Q9UM22,Q14849,O43292,P50897,Q99584,Q9BXW6,P04062,Q8WTV0,P07602,P53367,Q8NCC3,O00264,Q15067,O15118,O14773,Q07812,Q9NZJ7,O15173,Q13432 29 +Ganglioside binding 0.9296761015465356 3.3750208795805077 0.0007381009065243 0.6430040867577105 0.0072668197362447 3 Q9UM22,P07602 2 +Glycosphingolipid binding 0.9296761015465356 3.3750208795805077 0.0007381009065243 0.6430040867577105 0.0072668197362447 3 Q9UM22,P07602 2 +Transition metal ion transmembrane transporter activity 0.8792298716452656 3.3677600334908333 0.0007578152458493 0.6526953858333505 0.0072677639583173 2 Q9HD20 1 +Manganese ion transmembrane transporter activity 0.8792298716452656 3.3677600334908333 0.0007578152458493 0.6526953858333505 0.0072677639583173 2 Q9HD20 1 +Active transmembrane transporter activity 0.5736548342140123 3.3677372112832313 0.0007578779753985 0.6527257993867108 0.0072677639583173 74 P53985,Q9NUT2,Q9HD20,P55011,P14854,Q9P0J0,P20020,O43676,O95202,Q15043,Q8NE86,P13073,Q9UBX3,P08183,Q96ES6,P12235,P47985,Q03519,P03886,Q9Y6M9,P51798,P00403,Q03518,P12236,Q9UDW1,O14678,Q15388,P51970,P05141,P16615,Q7KZN9 31 +Steroid binding 0.7908983311849646 3.348808652212912 0.0008115982593801 0.6778181876180569 0.0073725654996225 23 O15118,P04062,Q14849,P30536,P45880,P38435,P21796,O15173,Q14108 9 +Arylsulfatase activity 0.87193698949825 3.3335490580639644 0.0008574554901437 0.6977991827931795 0.0074133039211602 2 P15289 1 +Tetrapyrrole binding 0.8476924617150987 3.330809067303828 0.0008659397526886 0.7013578600239332 0.0074133039211602 18 Q8WUJ1,P30519,O43169,Q9H7Z7,Q16850,P09601,Q6UW02,O15173,O00264 9 +Folic acid binding 0.8684364060676657 3.317075172267759 0.0009096513808564 0.7190394985664249 0.007501889382844 2 P00374 1 +Mhc class ib protein binding 0.910417274584181 3.288805609590508 0.0010061348751546 0.754452461065272 0.0080137932471313 3 Q03519,Q03518 2 +Anion transmembrane transporter activity 0.6439806651745335 3.275719054243827 0.0010539334608055 0.770307193956673 0.0081679843212427 43 P53985,P55011,Q9Y619,Q9H9B4,P45880,P21796,Q9BQT8,Q15043,Q9Y277,Q8TB61,Q9C0H2,Q9UBX3,Q14728,O43681,P12235,Q4KMQ2,P51798,P12236,Q96NB2,Q9Y6M7,P30825,O43808,P05141,Q9H2D1 24 +Nucleobase transmembrane transporter activity 0.8541423570594999 3.2494488918295876 0.001156288538644 0.8009015375863723 0.008625788831061 2 P12235 1 +Oxidative phosphorylation uncoupler activity 0.8541423570594999 3.2494488918295876 0.001156288538644 0.8009015375863723 0.008625788831061 2 P12235 1 +Tap1 binding 0.8935807502001583 3.2126602324682594 0.0013151176720063 0.8405135895715319 0.0096051788086325 3 Q03518 1 +Peptide transmembrane transporter activity 0.8935807502001583 3.2126602324682594 0.0013151176720063 0.8405135895715319 0.0096051788086325 3 Q03518 1 +Serine hydrolase activity 0.8223408362788993 3.1977044902846967 0.0013852615604545 0.8553993655352912 0.0099396024069302 18 P67812,Q16740,O14773,P42785,Q9H3G5,Q9HB40 6 +Ubiquinone binding 0.842765460910144 3.195207998420873 0.0013973009838843 0.8578109795112489 0.0099396024069302 2 P21912 1 +Death receptor binding 0.8421820303383891 3.1924163711873925 0.0014108779330652 0.860482390272471 0.0099402763465962 2 Q13546 1 +Sulfur compound transmembrane transporter activity 0.9304305688488684 3.165038552166543 0.0015506240406448 0.8852270403277634 0.0107085175084138 4 Q8TB61,Q9UBX3 2 +Organic hydroxy compound transmembrane transporter activity 0.8351808634772462 3.1588398379721685 0.0015839851382153 0.8904540465715229 0.0108316630775019 2 P53985 1 +Molecular transducer activity 0.6683453096887773 3.1256230310984163 0.0017742883406675 0.9160329345624714 0.0116203391325407 34 O15118,Q8WTV0,O15031,P30536,O15173,Q14108,Q99720,Q15629 8 +Neurotransmitter receptor regulator activity 0.8278879813302149 3.1237122141141285 0.0017858503223544 0.9173787494921608 0.0116255836998054 2 P49354 1 +Voltage gated chloride channel activity 0.8273045507584569 3.1208952614582177 0.0018030214987245 0.9193377998705312 0.0116255836998054 2 P51798 1 +Solute sodium symporter activity 0.8240956826137732 3.1053840887023605 0.0019003208503056 0.9295934941374726 0.0121047834985224 2 P55011 1 +Xenobiotic transmembrane transporter activity 0.8217619603267241 3.094084128662758 0.00197421496178 0.9365023243978984 0.0124616736275258 2 P08183 1 +Serine type carboxypeptidase activity 0.946836342782834 3.0827371182693506 0.00205106253949 0.9429695842701672 0.012773358225842 5 Q9H3G5,Q9HB40,P42785 3 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.910834872032019 3.079117110018601 0.0020761505214952 0.9449349821922116 0.0128721332332704 4 Q16850,Q15800 2 +Amide transmembrane transporter activity 0.9105239655846458 3.077746389242896 0.0020857233649833 0.9456669517428492 0.0128742659033265 4 Q9H2D1,Q03518 2 +Active ion transmembrane transporter activity 0.6381433406185065 3.0734904523381386 0.0021157045764941 0.947897088480673 0.0129107361304429 38 Q9HD20,P55011,P14854,P20020,O95202,P06576,Q15043,P13073,Q96ES6,P12235,P47985,P51798,P00403,P12236,Q9Y6M7,Q9UDW1,P05141,P16615,Q7KZN9 19 +Sterol transfer activity 0.9435582833875552 3.0687456848797146 0.0021495949553005 0.9503080617790326 0.0129107361304429 5 P30536 1 +Heme transmembrane transporter activity 0.8162193698949666 3.067181960993494 0.0021608727289739 0.9510853845443552 0.0129107361304429 2 O15173 1 +Mannosyl oligosaccharide mannosidase activity 0.8150525087514592 3.0615066921481273 0.0022022606901697 0.9538353755724108 0.0129523288856258 2 Q16706 1 +Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 0.8549751969652755 3.0352566053385517 0.0024033111569286 0.9651483300176904 0.0136841594445526 3 O75845,O95864 2 +Fatty acid synthase activity 0.8065927654609134 3.0202390609369503 0.0025257524096522 0.970632943710101 0.0142073573042939 2 P49327 1 +Ceramide binding 0.9302189781021784 3.011557321812574 0.002599113248962 0.9734966210622537 0.0145030519292079 5 Q9UM22,P21796,P07602,P45880 4 +Sterol binding 0.786078789061868 3.003532314052692 0.0026686520743144 0.9759530206085684 0.0147728954113834 18 Q14849,P30536,P45880,P21796,Q14108 5 +P type calcium transporter activity 0.843102561986426 2.9798932401413425 0.0028834885957003 0.9821950208222312 0.0154855844579361 3 P16615 1 +H4 histone acetyltransferase activity 0.8426203454741318 2.977636462011099 0.0029048030141904 0.9827181255901274 0.0155256712827422 3 Q86UY6 1 +Beta 2 microglobulin binding 0.7966744457409598 2.9715814087753647 0.0029627031613097 0.9840628977380348 0.0157746981298744 2 P55899 1 +Aspartic endopeptidase activity intramembrane cleaving 0.7952158693115381 2.9644006615896825 0.0030327314128155 0.985550400038327 0.0159647559278404 2 Q8TCT9 1 +Proton transmembrane transporter activity 0.6377013036499741 2.9486251223470497 0.0031919090104075 0.988435723620582 0.0166146010056662 35 O75964,Q13423,Q93050,P12235,P13073,P00403,P24539,Q96ES6,O95202,Q9UDW1,Q9Y487,P47985 12 +Cysteine type endopeptidase inhibitor activity involved in apoptotic process 0.879987676190403 2.9419590916957734 0.0032614300834759 0.98950787594858 0.0167867109991029 4 P51812 1 +Acid phosphatase activity 0.8798362014839356 2.9412797412286062 0.0032685920424637 0.9896125200994496 0.0167867109991029 4 Q9NPH0 1 +Ubiquinol cytochrome c reductase activity 0.879740855452054 2.940852093273846 0.0032731078077103 0.9896779636597004 0.0167867109991029 4 Q9UDW1 1 +Oxidoreductase activity acting on diphenols and related substances as donors 0.879740855452054 2.940852093273846 0.0032731078077103 0.9896779636597004 0.0167867109991029 4 Q9UDW1 1 +Serine type exopeptidase activity 0.936086998566212 2.9313986224633406 0.0033743948208 0.9910422911986992 0.0171798568431243 7 Q9H3G5,Q9HB40,O14773,P42785 4 +Porin activity 0.8751075879328145 2.920043308496958 0.0034998274484918 0.992484763678124 0.0175470484536166 4 P21796,P45880 2 +Wide pore channel activity 0.8751075879328145 2.920043308496958 0.0034998274484918 0.992484763678124 0.0175470484536166 4 P21796,P45880 2 +Phospholipid scramblase activity 0.8275459585643419 2.9067643094289934 0.0036518823778537 0.9939257737052102 0.0179379433700914 3 Q7Z3C6,Q96GC9 2 +Phosphatidylcholine binding 0.9266116094867982 2.89077523988264 0.0038429285260153 0.9953515084489124 0.0186141850478866 7 P21796,P45880 2 +Endopeptidase activity 0.53919220613056 2.8870984170178353 0.0038881259047331 0.9956366166355782 0.0187679433809785 65 Q16740,Q8TCT9,Q6NTF9,Q13867,P42574,P42892,P67812,P60900,O43292,P49721,Q9UPU5,Q92643,P28072,P14735,O75844,Q5JRX3,P28074,Q70CQ2,P22695,O14773,Q99797,Q14674,Q9NZ08 23 +Organic anion transmembrane transporter activity 0.6600196011616816 2.8697849847524566 0.0041075100400296 0.9967909386474988 0.019690640913544 28 P53985,Q8TB61,Q9Y619,Q9H9B4,Q9UBX3,O43808,Q9BQT8,Q14728,P05141,Q9H2D1,P12236,P12235,Q96NB2,P30825,Q9Y6M7 15 +Cholesterol binding 0.7941558897533869 2.853948789551307 0.004317949113467 0.997610285169819 0.0203497939638058 15 Q14849,P30536,P45880,P21796,Q14108 5 +Galactosyltransferase activity 0.892564740595909 2.8478917215904267 0.0044009895369048 0.9978727598572144 0.0206713144915226 5 Q96L58,O60512 2 +Alcohol binding 0.7671863993410881 2.8343755393806824 0.0045915339399056 0.9983712457771368 0.0214220396192921 17 Q14849,P30536,P45880,P21796,Q14108 5 +Adp transmembrane transporter activity 0.8546409807355375 2.82747303772111 0.0046916966126895 0.9985845649630376 0.021661617202953 4 P12236,P12235,O43808 3 +Diacylglycerol kinase activity 0.7666277712952203 2.822334420689943 0.0047675433772793 0.9987273162084466 0.0218056492173924 2 P52429 1 +Sulfuric ester hydrolase activity 0.8091625328275369 2.819475683337377 0.0048102175414033 0.9988012120826733 0.0219289329093386 3 O43681,P15289 2 +Hydrolase activity acting on glycosyl bonds 0.6425927011647691 2.811704094766979 0.0049279815554272 0.9989836412733346 0.0222476837211037 30 O60502,P04062,P16278,P17900,Q9BTY2,Q9NUJ1,O75503,P54802,P10253 9 +Scavenger receptor activity 0.8481686105207897 2.797975394060847 0.0051424029992188 0.9992475383816396 0.0228660685862548 4 Q14108 1 +Protein transporter activity 0.781629921332253 2.788618849992371 0.0052933321207131 0.999391072324807 0.0233677161658064 15 Q15388,Q9NS69,Q9HD20,Q99595,Q9Y584,O14925,P49755,O60830 8 +G protein alpha subunit binding 0.8788514815147795 2.787450580228761 0.0053124556474795 0.999407186433196 0.0233781565559429 5 P80303 1 +Vitamin transmembrane transporter activity 0.8774601650954498 2.781293038275392 0.0054142840504298 0.9994860821852424 0.0237513404099046 5 Q9H2D1,P38435,P04062 3 +1 phosphatidylinositol 3 kinase activity 0.7578763127187714 2.7783345795395644 0.0054638325712959 0.9995205856916788 0.023818895115493 2 Q13315 1 +Phosphatidylinositol 3 kinase activity 0.7578763127187714 2.7783345795395644 0.0054638325712959 0.9995205856916788 0.023818895115493 2 Q13315 1 +Acetylgalactosaminyltransferase activity 0.7990523837978797 2.7710625015887143 0.0055873700730342 0.9995968644699644 0.0242061529561576 3 Q8N4A0 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.7990523837978797 2.7710625015887143 0.0055873700730342 0.9995968644699644 0.0242061529561576 3 Q8N4A0 1 +Amide binding 0.475134608521105 2.755104144030706 0.0058673456231379 0.9997278217677792 0.0249541071471873 110 P55786,Q15392,P24390,P45880,Q9UIQ6,P21796,P52292,Q9UM22,P42892,Q9Y287,Q9H7Z7,P00374,O43731,Q9Y584,Q03519,Q8WTV0,Q9NQX7,P07602,Q03518,O00264,Q9Y680,P49748,O14773 23 +Secondary active transmembrane transporter activity 0.7218799421715294 2.7149493725592313 0.0066285902915623 0.9999065109709632 0.0272769423502345 19 P53985,P12236,Q8NE86,P12235,P55011,Q9UBX3,P51798,P05141,Q96ES6,O95202,Q15043 11 +Monooxygenase activity 0.8547563223983259 2.7067442169604123 0.0067946586084868 0.999925959411679 0.0277963306710824 10 P30519,Q15800,Q16850,P09601,Q6UW02 5 +Intramembrane lipid transporter activity 0.8277875072971395 2.704379035390557 0.0068432180349438 0.9999308410177578 0.0279131261951655 4 Q7Z3C6,Q96GC9,P08183 3 +Glycolipid binding 0.8623617858940165 2.695245478607714 0.0070336791140004 0.999947075923927 0.0282766062363994 9 Q9UM22,P07602,O14773,O43292,P50897 5 +Serine transmembrane transporter activity 0.782618160791797 2.6917400579579778 0.0071080322618237 0.9999523254797866 0.0283856974862705 3 Q96NB2 1 +Sphingolipid transporter activity 0.7406651108518032 2.691091794220226 0.0071218595843689 0.9999532427301564 0.0283856974862705 2 P08183 1 +Phosphatidylcholine transporter activity 0.7406651108518032 2.691091794220226 0.0071218595843689 0.9999532427301564 0.0283856974862705 2 P08183 1 +Hydrolase activity hydrolyzing o glycosyl compounds 0.6796116989257389 2.6877848847030688 0.0071927717174355 0.9999576768507658 0.0285866568257055 23 O60502,P04062,P16278,P17900,Q9BTY2,Q9NUJ1,P54802,P10253 8 +Sphingolipid binding 0.8789259828124734 2.6831929349782104 0.0072922907344876 0.9999632002017876 0.0287365694198031 7 Q9UM22,P45880,P07602,Q9NZJ7,P21796 5 +High density lipoprotein particle binding 0.7763650936474453 2.661353210841559 0.0077827267378631 0.9999815301788764 0.0302420718643987 3 Q9BQE5 1 +Protein lipid complex binding 0.7763650936474453 2.661353210841559 0.0077827267378631 0.9999815301788764 0.0302420718643987 3 Q9BQE5 1 +Protein adp ribosylase activity 0.7752723856663527 2.65603149140108 0.0079066230511664 0.9999844830000356 0.0306381643232698 3 Q9UGN5 1 +Peptidase activity 0.4548695005359421 2.633253258997587 0.0084571259483139 0.9999928461582712 0.0323224402682135 117 P55786,Q16740,Q9UIQ6,Q8TCT9,Q6NTF9,Q13867,P42574,P42892,P67812,P60900,P42785,Q9H3G5,O43292,P49721,Q9HB40,Q9UPU5,Q92643,Q969V3,P28072,P14735,O75844,Q5JRX3,P28074,Q92820,Q70CQ2,P22695,O14773,P10619,Q99797,Q14674,Q9NZ08,Q96FZ2 32 +Primary active transmembrane transporter activity 0.5260953013934042 2.617684193194098 0.00885286950304 0.9999959008999983 0.0335591112954916 56 Q9NUT2,Q9HD20,P14854,Q9P0J0,P20020,O43676,P13073,P08183,P47985,Q03519,P03886,Q9Y6M9,P51798,P00403,Q03518,Q9UDW1,O14678,Q15388,P16615,Q7KZN9 20 +Lipid transporter activity 0.667896123949584 2.6150972036964077 0.0089202065295559 0.9999962715595254 0.0336315894830555 23 Q9BXW6,O15118,O14678,P11166,P17900,O14975,Q14849,P30536,Q7Z3C6,Q4KMQ2,Q96GC9,P08183 12 +Palmitoyl protein hydrolase activity 0.8358311197409342 2.594866038045677 0.0094627793150925 0.9999982631389152 0.0352956608143157 5 P50897 1 +Mannosidase activity 0.7618658804253899 2.5904543914018885 0.0095849321590979 0.9999985376601472 0.0356139872046132 3 Q16706 1 +Sterol transporter activity 0.8296550725962131 2.589943009473786 0.00959918221429 0.9999985667186884 0.0356139872046132 10 O15118,Q14849,P30536 3 +Gpi anchor binding 0.7613072658301477 2.58771050248829 0.0096616142344281 0.9999986873777184 0.0357381239889782 3 Q92643,O43292 2 +Macromolecule transmembrane transporter activity 0.7801042135466788 2.5766564312596985 0.0099761053577105 0.9999991572109932 0.0367194379261377 13 Q9NS69,Q99595,Q9Y584,O14925,P49755,O60830 6 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.7986594221126144 2.5687158024751096 0.0102076133100021 0.9999993918201682 0.0373582558601793 4 Q7KZN9 1 +Quaternary ammonium group binding 0.8147537854881358 2.5665191099936613 0.0102724964730953 0.9999994449700008 0.0373582558601793 11 P21796,P45880,Q14108 3 +Cation chloride symporter activity 0.7132438739789803 2.55012182195355 0.0107685283534415 0.999999724193246 0.0387167449820901 2 P55011 1 +Potassium chloride symporter activity 0.7132438739789803 2.55012182195355 0.0107685283534415 0.999999724193246 0.0387167449820901 2 P55011 1 +Atp transmembrane transporter activity 0.8248409426176524 2.54493294361352 0.0109298725188125 0.9999997803233538 0.0391542968723832 5 P12235,P12236,O43808 3 +Protein transmembrane transporter activity 0.7913313744177679 2.5403989471939954 0.0110726085965673 0.999999820383334 0.0393723510864236 12 Q9NS69,Q99595,Q9Y584,O14925,P49755,O60830 6 +Nitric oxide synthase binding 0.7514885072266624 2.5393307846471367 0.011106475808384 0.9999998287626872 0.0393723510864236 3 P0DP25 1 +Lipase activator activity 0.7109101516919475 2.5380111422001255 0.0111484434975894 0.9999998386063076 0.0393723510864236 2 P42574 1 +Anion cation symporter activity 0.7475651712604119 2.519919613802162 0.0117381637941857 0.9999999297778408 0.0408347593338882 3 P55011 1 +Solute anion antiporter activity 0.7860478692352332 2.5092753279691955 0.0120979147643536 0.9999999577435053 0.0416705952994402 4 P12236,P12235,P05141 3 +Anaphase promoting complex binding 0.7039089848307979 2.5015717115762115 0.0123643399163408 0.9999999709942864 0.04248338468792 2 Q16763 1 +Adp ribose diphosphatase activity 0.701283547257878 2.4878653066972265 0.0128512394608817 0.9999999854208113 0.0436191704329197 2 Q9UKK9 1 +Hexosaminidase activity 0.8113850579811763 2.4833845246564605 0.0130140521252419 0.9999999884174968 0.0439578758225485 5 P17900,P54802 2 +Cysteine type endopeptidase regulator activity involved in apoptotic process 0.8411328789285502 2.476843882508766 0.0132549866523572 0.9999999917606732 0.0446635419807689 6 Q9BXK5,P51812 2 +Rage receptor binding 0.7357578832108452 2.4612254592380727 0.0138463323690283 0.9999999964296648 0.0464492849743237 3 Q99584 1 +Peroxisome targeting sequence binding 0.729833408182945 2.431618112268588 0.0150315465116572 0.9999999993329812 0.0499262080565759 3 Q9NXR7 1 +Voltage gated anion channel activity 0.8303343561678006 2.428657055073318 0.0151548597468536 0.9999999994398748 0.0502162217265101 6 P21796,P45880,Q9Y277 3 +Exopeptidase activity 0.579599847165273 2.4272875642293603 0.0152121928724411 0.999999999483566 0.0502285993800218 32 P55786,O14773,P42785,Q9H3G5,O75844,P10619,Q9HB40 7 +Frizzled binding 0.6893232205367592 2.425136783517401 0.0153026198827999 0.9999999995456594 0.0502285993800218 2 O00560 1 +Acetylcholine receptor binding 0.6893232205367592 2.425136783517401 0.0153026198827999 0.9999999995456594 0.0502285993800218 2 O15258 1 +Beta 2 adrenergic receptor binding 0.6893232205367482 2.4251367835173427 0.0153026198828023 0.9999999995456594 0.0502285993800218 2 P46934 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.5704304093775391 2.4219530265395206 0.0154373458671759 0.999999999624608 0.0505518720298366 34 P30519,Q9NVH6,Q15800,O95864,Q16850,P09601,Q14534,P13674,O00767,Q6UW02,P16435,O75592,O75845,Q6P6C2 14 +Nucleobase containing compound transmembrane transporter activity 0.7637039389225593 2.4030511536143573 0.0162589128954366 0.9999999998828532 0.0529934193671359 12 Q9BSK2,Q8TB61,O43808,P05141,Q9H2D1,P12236,P12235 7 +Lipid transfer activity 0.8061467797188683 2.394510880714297 0.0166425496498325 0.9999999999320138 0.0534939095887475 8 P30536 1 +Pyruvate dehydrogenase acetyl transferring kinase activity 0.7221808185322356 2.3932190880980233 0.0167012649505371 0.9999999999374474 0.0535592289793087 3 Q15120 1 +Peptide hormone binding 0.720158492365641 2.383042171422902 0.0171702272378677 0.999999999967846 0.053946997740598 3 P42892 1 +Nucleotide transmembrane transporter activity 0.7839494954072836 2.3729956245865504 0.0176444729371501 0.9999999999836008 0.0551189775478704 10 Q9BSK2,Q8TB61,O43808,Q9H2D1,P12236,P12235 6 +Organophosphate ester transmembrane transporter activity 0.7839494954072836 2.3729956245865504 0.0176444729371501 0.9999999999836008 0.0551189775478704 10 Q9BSK2,Q8TB61,O43808,Q9H2D1,P12236,P12235 6 +Oxidoreductase activity acting on a heme group of donors 0.8095598943263866 2.371583687348735 0.0177120350857167 0.9999999999851008 0.0551524306798545 7 P13073,Q7KZN9,P00403,P16435 4 +Leukotriene c4 synthase activity 0.6770711785297621 2.3603865362647434 0.0182559019865009 0.9999999999931194 0.0562185061173705 2 Q99735 1 +Beta n acetylhexosaminidase activity 0.7535401308371517 2.3540785338904886 0.0185686875684594 0.9999999999955886 0.0568183062537389 4 P17900 1 +P type transmembrane transporter activity 0.7529594112567304 2.3512799897848664 0.0187089499568675 0.999999999996386 0.0571093767829983 4 P16615 1 +Potassium ion transmembrane transporter activity 0.7134519988328016 2.349205352250404 0.0188135277145646 0.9999999999968852 0.0573032121437068 3 P55011,P05023 2 +Immunoglobulin binding 0.7098633079427499 2.331043556194359 0.0197510630830934 0.9999999999991792 0.0592531892492804 3 P55899 1 +Magnesium ion transmembrane transporter activity 0.6703617269544955 2.324716606382908 0.020087118715264 0.9999999999994912 0.060003277532748 2 Q6P4Q7 1 +Glucosidase activity 0.7763896773798815 2.3211685431682345 0.0202777492174042 0.9999999999996122 0.0601860854431465 5 P04062 1 +Peptide binding 0.4637117258833765 2.310205700330303 0.0208767686141988 0.9999999999998348 0.0617014665610326 80 P55786,Q15392,P42892,P24390,Q03519,Q9Y287,Q8WTV0,Q9NQX7,Q9H7Z7,O14773,Q9UIQ6,Q03518,O43731,P52292,Q9Y584 15 +Antiporter activity 0.786998987986468 2.3052386613900206 0.0211532107200118 0.9999999999998884 0.0623863191425297 8 O95202,Q9UBX3,P51798,P12236,P12235 5 +Protein prenyltransferase activity 0.7416054952667661 2.2963797740012484 0.0216541764113702 0.9999999999999456 0.063461294314835 4 P49356 1 +Mitochondrion targeting sequence binding 0.7005210277951943 2.2835822445674903 0.0223960942556562 0.999999999999981 0.0654413978441595 3 Q9Y584 1 +Peptide antigen binding 0.7787783105317163 2.266627599676323 0.0234129846046395 0.9999999999999956 0.0677616463142577 8 Q15392,P55899,Q03519,Q03518 4 +Inorganic anion transmembrane transporter activity 0.6445645732681518 2.2602855317393615 0.0238035353507044 0.9999999999999974 0.0683249625807257 19 Q9Y277,P55011,P45880,Q9C0H2,Q9UBX3,P51798,P21796,Q15043 8 +Atpase coupled transmembrane transporter activity 0.6026108012336766 2.248713315676257 0.0245307414568698 0.9999999999999992 0.0699803360579415 24 O14678,Q03519,Q15388,Q9NUT2,Q9HD20,P51798,Q9Y5K8,P20020,P08183,Q03518,P16615,P06576 12 +Neurexin family protein binding 0.6551925320886876 2.2435193486097713 0.0248633435822522 0.9999999999999994 0.0706402531512055 2 O00560 1 +Cyclin dependent protein serine threonine kinase regulator activity 0.7590171794640476 2.2394846559789023 0.0251243985960358 0.9999999999999996 0.0712368618729066 5 P14635,O95067,P42574 3 +Organic cation transmembrane transporter activity 0.7261468699429873 2.221067196695265 0.0263464104349648 1.0 0.0740992793483387 4 O43772,Q70HW3 2 +Abc type transporter activity 0.7504034414554576 2.210206561996524 0.0270908297741394 1.0 0.0754325499699092 10 O14678,Q03519,Q9NUT2,Q9HD20,Q03518 5 +Cargo receptor activity 0.772642393500772 2.2009627827618496 0.0277386586765644 1.0 0.0769292820155216 7 O15260,Q14108,Q8WTV0 3 +Carbohydrate derivative transmembrane transporter activity 0.7519943121058008 2.177580173956692 0.0294373069125417 1.0 0.0811562117450509 9 Q8TB61,O43808,P05141,P12236,P12235 5 +Palmitoyltransferase activity 0.7449370404800306 2.172718313954127 0.0298015245397069 1.0 0.0819982775796671 5 O15269,P23786 2 +Dynactin binding 0.7427316612362916 2.162215146365829 0.0306015965986392 1.0 0.0835405621430562 5 P42858,Q9Y5X3 2 +Purine nucleotide transmembrane transporter activity 0.750489681489934 2.1324583495982345 0.0329691849861324 1.0 0.0891492345396194 8 Q8TB61,P12236,O43808,P12235 4 +Cullin family protein binding 0.7647865806238031 2.1302148296960053 0.0331538812866973 1.0 0.0894577647871235 6 Q96GG9,Q92564 2 +Antigen binding 0.7304993860951058 2.1121900731485352 0.0346701496255177 1.0 0.0931885524616517 10 Q15392,P55899,Q03519,Q03518 4 +Snap receptor activity 0.7285548072262591 2.1025573505229724 0.0355044814201206 1.0 0.0948826658641154 10 O95249,O15400,Q13277,O15498,Q9P2W9,Q13190,Q86Y82 7 +Oxidative rna demethylase activity 0.6648697344441171 2.1000592286496715 0.0357236312716489 1.0 0.0951039420304393 3 Q6P6C2 1 +Anion channel activity 0.7193851902143035 2.0979570938998644 0.0359089357495727 1.0 0.095415172134579 11 Q9C0H2,P21796,P45880,Q9Y277 4 +Organic acid transmembrane transporter activity 0.6165250515609034 2.0894293933533574 0.0366690876118622 1.0 0.0968452609282837 19 P53985,Q9Y619,Q9UBX3,Q9BQT8,P08183,Q9H2D1,Q96NB2,P30825 8 +Oxidoreductase activity 0.3635431885972303 2.0882106971513217 0.0367788327930893 1.0 0.0968452609282837 243 P30519,Q15392,Q13423,Q8NBX0,Q96CU9,P14406,O43169,P14854,Q14534,Q8N4Q0,P09601,Q16850,O43396,O95864,Q9P0J0,Q8N0U8,O43676,P21912,Q9H3N1,O76062,O43708,Q9H7Z7,P32119,P13073,P00374,P16435,Q14739,Q99536,P47985,P03886,Q53GQ0,O00116,P51648,P00403,Q06136,Q9UDW1,O95881,Q15067,Q9UHG3,Q15800,Q16836,P78417,P49748,Q3SXM5,Q6UW02,Q6NUM9,Q96LJ7,Q7KZN9 48 +Glycosyltransferase activity 0.4775040257708894 2.0880396648350974 0.0367942568401364 1.0 0.0968452609282837 51 Q10472,P04062,P43490,O60512,P09874,Q96L58,Q9UGN5,Q9ULX3,Q13126,Q9BT22,O43505,Q6ZXV5,Q8NAT1,Q8N4A0,Q2TAA5,Q8IXJ6 16 +Amyloid beta binding 0.6911997949254873 2.0320028267107713 0.0421533697832725 1.0 0.1076995436770425 12 Q9NQX7,Q9Y287,Q8WTV0 3 +Nadph binding 0.7151397976845405 2.029773997607717 0.0423795172023515 1.0 0.1080793903058143 5 P00374 1 +Phospholipid binding 0.4206564554154798 2.0271881967630425 0.042643169789245 1.0 0.1083555953661145 104 Q9UM22,Q8WTV0,Q9Y5X3,P45880,P07602,O14773,O43292,P53367,Q9NZJ7,P21796,P50897,Q14108,Q8NCC3 13 +Pre mirna binding 0.7129622504281263 2.0192408567644677 0.0434621917009891 1.0 0.1099863064629582 5 O75569,Q9H2U1,Q9HAV4 3 +Quinone binding 0.7128444375977007 2.018670643134078 0.0435214632025469 1.0 0.1099863064629582 5 P21912,Q8N0U8 2 +Passive transmembrane transporter activity 0.5210511990402376 2.0162927905568053 0.0437693683523858 1.0 0.1103870962155395 33 O75964,P56385,Q9UM00,Q9Y277,Q8NE86,P45880,Q9C0H2,Q00535,Q07812,P51798,P21796,Q99797,P24539,P06576 14 +Metalloendopeptidase activity 0.6551463413338288 2.006796175378442 0.0447713702827092 1.0 0.1119284257067732 14 O75844,P42892,P22695,P14735 4 +Tap binding 0.737899235157462 2.004856155328319 0.0449784271353068 1.0 0.112244912081848 6 Q03518,Q03519,P01889 3 +Transferase activity transferring alkyl or aryl other than methyl groups 0.5586142064911889 2.0024030712740637 0.04524139843488 1.0 0.112498664557322 25 P78417,O00116,P49354,O15217,P49356,P37268 6 +Nucleoside diphosphatase activity 0.6105600933488804 2.000199220523859 0.0454787559643419 1.0 0.1128876593776814 2 Q9UKK9 1 +5 deoxyribose 5 phosphate lyase activity 0.6038506417736387 1.9630613810080444 0.0496390422296448 1.0 0.1216985305981627 2 P12956 1 +Histone serine kinase activity 0.6733371942194384 1.95891723367253 0.0501224804297837 1.0 0.1218133452953803 4 P54646 1 +Phosphatase activator activity 0.7276857240833419 1.9567977985600071 0.0503712460146323 1.0 0.1221503763961318 6 P0DP25,P35269 2 +1 alkyl 2 acetylglycerophosphocholine esterase activity 0.6000583430571783 1.942007162576777 0.0521362332033734 1.0 0.1260416310003136 2 P68402 1 +Hexosyltransferase activity 0.4993175916852022 1.9323979314320028 0.0533104091718723 1.0 0.1279510953716765 36 Q10472,P04062,O60512,Q96L58,Q13126,Q9BT22,O43505,Q6ZXV5,Q8N4A0,Q2TAA5 10 +Phosphatidylinositol 4 phosphate binding 0.7085177719887353 1.929714933194056 0.0536421686315109 1.0 0.1281349747276674 8 P53367,Q9Y5X3 2 +Mhc protein binding 0.6815507932813345 1.90513115361146 0.0567630246793708 1.0 0.133307103413674 11 Q03519,Q9NUQ9,Q03518,Q9BUN8 4 +Long chain acyl coa dehydrogenase activity 0.6620902588528421 1.9021353069905025 0.0571534676979617 1.0 0.1337228934272072 4 P49748 1 +Chemoattractant activity 0.6605820416966668 1.894496193921224 0.0581591790859077 1.0 0.1354458344321223 4 P09429 1 +Single stranded dna exodeoxyribonuclease activity 0.6810587948004656 1.8635939905909569 0.0623787422043027 1.0 0.1424195505319186 5 Q9UQ84,Q8IV08 2 +Fad binding 0.6432748632288194 1.8564513827382636 0.0633892466259729 1.0 0.1435519464987535 13 Q15067,Q15392,Q8NB78,O00116,Q14534,O15254 6 +Carboxypeptidase activity 0.641784904773431 1.848296494050642 0.0645594626489758 1.0 0.1450694950064044 13 Q9H3G5,Q9HB40,P42785 3 +Oxidoreduction driven active transmembrane transporter activity 0.5021172841666097 1.8431222826306897 0.0653111586459005 1.0 0.1464551962408105 32 Q7KZN9,P03886,P14854,P13073,Q9Y6M9,Q9P0J0,P00403,O43676,Q9UDW1,P47985 10 +Mhc class i protein binding 0.6767855229495542 1.842471882237931 0.0654061557405196 1.0 0.1464551962408105 10 Q03519,Q03518 2 +Minor groove of adenine thymine rich dna binding 0.6493483369958363 1.837417243466954 0.0661483231661379 1.0 0.1474072057775757 4 Q03164 1 +Alpha glucosidase activity 0.6126581558407684 1.82456358008447 0.0680669135797371 1.0 0.1509592121521992 3 P10253 1 +Signaling receptor regulator activity 0.5980228438272853 1.816178662438805 0.0693429701134751 1.0 0.1533018118990456 16 P05067,P09429,P43490,Q9UMX5,P17931,P49354 6 +Cytokine activity 0.6686836491061323 1.802569893551953 0.0714557887664395 1.0 0.1567308574358225 5 P43490 1 +Nadplus adp ribosyltransferase activity 0.6938693482861438 1.7960089871140534 0.0724930877309562 1.0 0.1582613442410212 6 P09874,Q9ULX3,Q9UGN5 3 +Death domain binding 0.6392955102307779 1.786073942646007 0.0740872865701764 1.0 0.1612352024421157 4 Q07812,Q13546 2 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.6800766963344874 1.7587357481139114 0.0786224025255863 1.0 0.1678771000407652 7 P50750,P06493,P11802 3 +Prenyltransferase activity 0.6727250610829338 1.7534832508355054 0.0795190920453912 1.0 0.1683294892311392 8 P49356,P49354,P37268 3 +Threonine type endopeptidase activity 0.6724964923090697 1.7523484771855982 0.0797139050656428 1.0 0.1684862084341995 8 P20618,P28074,P49721,P28072 4 +Neutral amino acid transmembrane transporter activity 0.632507036498307 1.7512653609428377 0.0799002114568316 1.0 0.168624500729622 4 Q96NB2 1 +Symporter activity 0.6637582659604389 1.741240171605292 0.0816414884135097 1.0 0.1707494397853763 9 P55011,P53985,Q96ES6,Q15043 4 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.6041874556475058 1.7198456973527343 0.0854604935078084 1.0 0.1784691443763366 14 Q15392,O76062,Q9H7Z7,Q9UBM7,Q8N4Q0,Q14739 6 +Mannose binding 0.6689742430408028 1.676081836739793 0.0937221639512704 1.0 0.1925514266745541 6 P35613,O75503 2 +Four way junction helicase activity 0.5516336056009423 1.669332783520692 0.0950514465778549 1.0 0.1942356869771695 2 P46063 1 +Solute cation symporter activity 0.6612593863906808 1.6664732648647478 0.0956191888632878 1.0 0.1944442688983767 7 P55011,Q96ES6,Q15043 3 +Exogenous protein binding 0.5655805776885805 1.6215048588458407 0.104909408781358 1.0 0.2096685175501353 16 P35613,O15118,Q8WTV0,P14735,Q14108 5 +Bh domain binding 0.5733641912054256 1.612357378160305 0.106884194038048 1.0 0.2123004154489107 3 Q07812 1 +Bh3 domain binding 0.5733641912054256 1.612357378160305 0.106884194038048 1.0 0.2123004154489107 3 Q07812 1 +Proline rich region binding 0.6547677815821457 1.607099789342881 0.1080324795207703 1.0 0.2133514581183744 6 Q9UQB8 1 +Calcium ion binding 0.3952666242030593 1.6066614243788666 0.108128660135979 1.0 0.2133514581183744 91 P80303,O95302,O95202,Q9BRK5,P55327,Q9UM22,Q02818,P0DP25,Q9H223,Q99584,Q96A33,Q9NWM8,P41208,O75071,Q9Y680,Q14257,Q96AY3,P16615,Q8IYU8,Q66K14 20 +Nucleotidase activity 0.6501210266094299 1.5844564206576384 0.1130898912693814 1.0 0.2209529388246317 6 P49902,Q969T7 2 +Gated channel activity 0.5931492158904709 1.5787532792475358 0.1143926588101345 1.0 0.2219695561685401 13 Q9C0H2,P21796,P45880,Q9Y277 4 +Aspartic type peptidase activity 0.6212195321080529 1.5654312675620357 0.1174818217210944 1.0 0.226990500416796 5 Q8TCT9,P42574 2 +Phosphatidylinositol kinase activity 0.5962154375274253 1.5634257440374784 0.1179524888117504 1.0 0.227578237811971 4 Q9BTU6,Q13315 2 +Udp glycosyltransferase activity 0.5483143637593444 1.561411551922472 0.118426677981176 1.0 0.2278692631499869 17 Q8N4A0,Q96L58,O43505,O60512 4 +Oxidoreductase activity acting on the ch ch group of donors 0.4674982086725318 1.548768359002182 0.1214374142915675 1.0 0.2320619081325159 31 Q15067,Q15392,Q7KZN9,O76062,Q6NUM9,P49748,Q9H7Z7,Q9UBM7,Q8N4Q0,Q14739,P21912 11 +Rna directed dna polymerase activity 0.5591538368732406 1.534719386524282 0.124852771702014 1.0 0.2366435007123771 3 Q15554 1 +Telomerase activity 0.5591538368732406 1.534719386524282 0.124852771702014 1.0 0.2366435007123771 3 Q15554 1 +Electron transfer activity 0.4130876930301773 1.525622702193441 0.1271038549587697 1.0 0.2402572868123086 54 P47985,Q7KZN9,P14406,P03886,P13073,Q9P0J0,P00403,O43676,Q9UDW1,P21912 10 +Exodeoxyribonuclease activity 0.6143818268711605 1.5203193655392588 0.1284307292090614 1.0 0.2424368974920712 10 Q9UQ84,Q8IV08,P28340 3 +Modified amino acid binding 0.5077707191596922 1.5194665097448488 0.1286451117282738 1.0 0.2425134200823541 22 P09429,P04818,Q8WTV0,Q9H7Z7,P00374,Q14108 6 +Atpase binding 0.4750584361842956 1.4987011865654178 0.1339511687704733 1.0 0.2504850944166357 27 Q93050,Q8NFQ8,Q9Y487,Q16740 4 +Phosphoric diester hydrolase activity 0.5873817720635007 1.4752977261257867 0.1401325175017782 1.0 0.2606464825533075 12 P09601,Q8N2A8 2 +Hyaluronic acid binding 0.5172112018669843 1.471683028796943 0.1411064926063754 1.0 0.2621085981170356 2 Q07021 1 +Deoxynucleoside kinase activity 0.516627771295233 1.4683105968664056 0.1420198737778015 1.0 0.2632959908642734 2 P55263 1 +Protein phosphatase activator activity 0.5970895557968865 1.4432444016128776 0.1489516356592202 1.0 0.2740220952285132 5 P0DP25 1 +Voltage gated channel activity 0.5930452117582211 1.4401215623326329 0.1498330096720606 1.0 0.2750224322270059 11 P21796,P45880,Q9Y277 3 +Dicarboxylic acid transmembrane transporter activity 0.6154135471989168 1.4388985261161036 0.1501792751917063 1.0 0.2752957804105524 7 Q9UBX3 1 +Fk506 binding 0.6196492710510834 1.4350923998752028 0.1512607690062646 1.0 0.2765514715121089 6 Q9Y680 1 +Macrolide binding 0.6196492710510834 1.4350923998752028 0.1512607690062646 1.0 0.2765514715121089 6 Q9Y680 1 +Dna directed dna polymerase activity 0.6137794955425692 1.4307246643869405 0.15250914154463 1.0 0.2781049051696195 7 Q9NRF9,Q9NR33,P28340,Q9NRG0,Q07864 5 +Amino acid transmembrane transporter activity 0.5981098546828534 1.4051944308363131 0.1599634697584666 1.0 0.2893990754501371 9 Q9Y619,Q96NB2,P30825 3 +Steroid dehydrogenase activity 0.6085518447758005 1.404550783395272 0.1601549005358464 1.0 0.2893990754501371 7 Q3SXM5 1 +Cyclin dependent protein kinase activity 0.6029344738063251 1.402199328469332 0.1608557321358168 1.0 0.2895403178444702 8 P50750,P06493,P11802,Q00535 4 +Pentosyltransferase activity 0.5290034701260712 1.3983779867853428 0.161999590018413 1.0 0.2912234897882554 16 P43490,P09874,Q9UGN5,Q13126,Q9ULX3 5 +Dna polymerase activity 0.588093431486794 1.382285864256409 0.1668839445844661 1.0 0.2977021773597572 10 Q15554,Q15185,P28340,Q07864 4 +Glutathione transferase activity 0.5966668952393321 1.370258195832981 0.1706063176440766 1.0 0.3035660881549578 8 O15217,P78417 2 +O acyltransferase activity 0.5431346800291158 1.3666074893517344 0.1717483684684615 1.0 0.3052088840936354 14 O15228,Q9NUQ2,Q8NCC3,Q96N66,P23786 5 +Pdz domain binding 0.5427071523585502 1.3641052226045758 0.1725344513092861 1.0 0.3062157246519773 14 Q15067,P20020,Q9UQB8 3 +Metal ion transmembrane transporter activity 0.4900557291854152 1.3627479146920358 0.1729619713859134 1.0 0.3065844346675339 21 Q9UM00,Q8NE86,Q9HD20,P55011,Q00535,P20020,P16615,O95202,Q15043 9 +Myosin v binding 0.5783933499182058 1.3479929093702112 0.1776606631987873 1.0 0.3121368075092045 5 Q15907,P20337 2 +Metallopeptidase activity 0.4138417522667486 1.337015747309502 0.1812174966818669 1.0 0.3168313313494916 41 P55786,P42892,P14735,P22695,Q9UIQ6,O75844,Q99797,Q9NZ08 8 +Signal sequence binding 0.4450420364251079 1.3338156525872626 0.1822642798852132 1.0 0.3182211144428941 29 O43731,P24390,Q9Y584 3 +Dna secondary structure binding 0.5787423401744282 1.3329387191914672 0.1825519148970347 1.0 0.3183249016017043 10 P09429,O15347,P07305,P17096,Q03164,P52701 6 +Phosphoserine residue binding 0.5506762807539076 1.3243045138805936 0.1854019320150088 1.0 0.3228910051946783 4 P46934,Q92541 2 +Protein arginine n methyltransferase activity 0.5968847921289941 1.322687504664115 0.1859393205948873 1.0 0.3234231324561944 6 Q6P2P2,Q7L592,O14744 3 +S methyltransferase activity 0.5491214850453154 1.3160923862117149 0.1881430361462517 1.0 0.3260366899677281 4 Q03164 1 +Ribose phosphate diphosphokinase activity 0.5185293259410709 1.3107641796016465 0.1899374479612141 1.0 0.3271144937109799 3 Q14558,P11908 2 +Diphosphotransferase activity 0.5185293259410709 1.3107641796016465 0.1899374479612141 1.0 0.3271144937109799 3 Q14558,P11908 2 +Plus end directed microtubule motor activity 0.5657061834900579 1.2831418318392789 0.1994423904704731 1.0 0.3376482217309589 5 Q9Y496 1 +Threonine type peptidase activity 0.5730691200811859 1.2751939781489268 0.2022405922061372 1.0 0.3411454723452495 9 P20618,P28074,P49721,P28072 4 +Oxidoreductase activity acting on ch or ch2 groups 0.4833722287047949 1.2751905758481352 0.2022417961501945 1.0 0.3411454723452495 2 P31350 1 +Transmembrane transporter binding 0.4181181597047732 1.233735947864087 0.2173013140170583 1.0 0.3617366742885398 35 P42858,P30536,P0DP25,P21796,P16615 5 +Rna polymerase ii general transcription initiation factor activity 0.5718960409172438 1.2202163602827167 0.2223828664976914 1.0 0.3684371719290731 7 P35269 1 +Procollagen proline dioxygenase activity 0.5286388836853604 1.2077440263853865 0.227145737633577 1.0 0.3749920757382721 4 P13674,Q32P28 2 +Sequence specific mrna binding 0.5668861214661237 1.194951391750382 0.2321060221276751 1.0 0.3818253547972958 7 P00374 1 +Thiolester hydrolase activity 0.4990589957516269 1.177084485111613 0.239161786973773 1.0 0.3893006917484403 15 P50897 1 +Translation repressor activity mrna regulatory element binding 0.5666196134520449 1.1725976988077456 0.240957172669046 1.0 0.3913099602716172 6 P00374 1 +Tumor necrosis factor receptor superfamily binding 0.5664202567903616 1.171607948897414 0.2413544952285158 1.0 0.3914994428416041 6 Q13546,P42574 2 +Oligosaccharyl transferase activity 0.5208345668503936 1.1664172925726717 0.2434457702829469 1.0 0.3939754635089453 4 Q8TCJ2,P46977 2 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.5208345668503936 1.1664172925726717 0.2434457702829469 1.0 0.3939754635089453 4 Q8TCJ2,P46977 2 +Phosphatidylserine binding 0.5463133931404902 1.1611675645122708 0.2455737625194425 1.0 0.3945400821465407 10 Q14108 1 +General transcription initiation factor activity 0.5550551809705258 1.1572872304311506 0.2471550289065638 1.0 0.3953450676828214 8 P35269 1 +Endoribonuclease activity producing 5 phosphomonoesters 0.5073298045230588 1.156212336952545 0.2475943148173827 1.0 0.3953450676828214 14 Q9UQ84 1 +Protein homodimerization activity 0.3072193130784943 1.1428655633865736 0.2530944122623311 1.0 0.4016686064914128 186 Q8N2A8,Q5HYI8,O95684,Q8NAN2,P09601,Q8TCT9,Q14108,P31939,Q8TBA6,P55327,P42892,P16278,Q14849,Q99584,P14735,P07602,P51648,Q03518,O00264,Q15067,Q07812,Q9NZJ7,Q03164,O15217,Q15070 25 +Phosphatase regulator activity 0.4435990344394185 1.1410432086392583 0.2538519425653578 1.0 0.4023479711623366 24 O14974,Q6IN85,Q86XL3,P0DP25,P78318,P17931,P35269,Q9Y570,Q01105 9 +Adrenergic receptor binding 0.537810218978104 1.1402350059772584 0.2541884070887819 1.0 0.4023479711623366 5 P46934,Q15334,Q07021,Q9Y4G8 4 +Sodium ion transmembrane transporter activity 0.5355197393941247 1.1284974947421833 0.2591098743031055 1.0 0.4093020386753575 5 P55011,Q9Y6M7,P05023 3 +L amino acid transmembrane transporter activity 0.5491848854382044 1.1271839044834904 0.2596647342133988 1.0 0.4093020386753575 8 Q9Y619,P30825 2 +Acylglycerol o acyltransferase activity 0.5479434505085168 1.120818163361467 0.2623652710786743 1.0 0.4112354529828659 8 Q9NUQ2,Q8NCC3,Q96N66 3 +Dopamine receptor binding 0.554140828113871 1.1106488596545825 0.2667195229543502 1.0 0.4171230207638099 6 Q9Y5X3 1 +5 3 exonuclease activity 0.5336630211045331 1.094050075970066 0.2739330164124531 1.0 0.4268109366315438 10 Q9UQ84 1 +Cysteine type endopeptidase inhibitor activity 0.532131405725156 1.0859258843908184 0.2775117839984706 1.0 0.4301432651976295 10 P51812 1 +Procollagen proline 4 dioxygenase activity 0.4757907061521762 1.0736212683045168 0.2829924613051051 1.0 0.4371810448733351 3 P13674 1 +Peptidyl proline 4 dioxygenase activity 0.4757907061521762 1.0736212683045168 0.2829924613051051 1.0 0.4371810448733351 3 P13674 1 +Four way junction dna binding 0.539633853922711 1.0387053079466295 0.2989418118056284 1.0 0.4567621330436491 6 P52701,P09429,O15347 3 +Peroxisome proliferator activated receptor binding 0.4416569428238033 1.03204842548887 0.3020494326380158 1.0 0.4610054250875625 2 P17096 1 +Phospholipid transporter activity 0.5295132171270138 1.0263904706139817 0.3047075680065503 1.0 0.4635409567820476 8 Q7Z3C6,Q4KMQ2,Q96GC9,P08183,Q9BZF1 5 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.4728023092053214 1.0174698808907827 0.3089299533228418 1.0 0.4684318313971351 15 Q9UQ84 1 +Heparin binding 0.5034890929647295 1.010946978128043 0.3120418077107936 1.0 0.4726366142850783 12 O14737,P05067,Q53GQ0,P47914 4 +Nuclear export signal receptor activity 0.5242383135704429 0.9994131003433464 0.3175946162802985 1.0 0.4779336458587016 8 Q96QU8,P55060,Q9C0E2 3 +Phosphatidylinositol phosphate 4 phosphatase activity 0.4618768929904517 0.9966101983236484 0.3189537538192022 1.0 0.4794617312260636 3 Q01968 1 +Hormone binding 0.5226930485823623 0.9915162938163826 0.321433540141804 1.0 0.4826693094702008 8 P42892,P30536 2 +Protein tyrosine kinase activator activity 0.4343640606767927 0.9896997382890456 0.3223209029646146 1.0 0.4834813544469218 2 Q13177 1 +Sodium channel regulator activity 0.5161951951313225 0.9788941865821492 0.3276322649118732 1.0 0.4903937870730292 9 Q8N335,Q96BR1,Q9HD47,Q99959,P46934 5 +Nadp binding 0.4368397043554107 0.971733867858854 0.3311829632948762 1.0 0.4951770994601846 20 O76062,Q13423,P00374,P16435,Q14739 5 +Molecular function activator activity 0.4839403095641537 0.9577981055190038 0.3381645746890258 1.0 0.5029206627837858 13 Q8NFQ8 1 +Peptidase activator activity 0.5023330128138135 0.9515773437718416 0.3413113762055171 1.0 0.5059823271059473 11 Q9BXK5,P05067 2 +Ubiquitin conjugating enzyme binding 0.5143498855524866 0.9489383248020562 0.342651981050714 1.0 0.5074304814922994 8 Q96GG9,Q92564 2 +Scaffold protein binding 0.4153824444560092 0.9368649358508376 0.3488280378024999 1.0 0.5143922967595004 24 P07602,Q9UQB8 2 +Lys63 specific deubiquitinase activity 0.4247374562427115 0.9339848334925474 0.3503117164571692 1.0 0.5154903422550117 2 O95630 1 +Histone arginine n methyltransferase activity 0.4470382258535337 0.9148805603551396 0.3602543364299579 1.0 0.5247725183551311 3 Q86X55,O14744 2 +Protein arginine omega n asymmetric methyltransferase activity 0.4470382258535225 0.9148805603550778 0.3602543364299904 1.0 0.5247725183551311 3 O60678,Q86X55 2 +Chloride channel regulator activity 0.4722169950970405 0.9099073989259548 0.3628713474330216 1.0 0.5272974267386095 4 Q96BR1,O15400 2 +Atpase activator activity 0.4844517716539446 0.9056520399596958 0.3651200549785456 1.0 0.529362383231354 12 Q8NFQ8 1 +3 5 exodeoxyribonuclease activity 0.5119962556770936 0.902297948331802 0.3668986151573272 1.0 0.530387117248157 6 P28340 1 +Signal recognition particle binding 0.5075411104381614 0.8804426719928968 0.3786195484755139 1.0 0.5461988315649865 6 Q9BUN8 1 +O methyltransferase activity 0.4980409311582278 0.8660875595493894 0.3864421468653403 1.0 0.5529095332073329 8 O60725 1 +Phosphatidylinositol 3 kinase binding 0.481961209614922 0.8556199078365306 0.3922080546279041 1.0 0.5600104771810913 5 P0DP25,P50570,O14654 3 +Protein methyltransferase activity 0.3904475516899305 0.8535772276451035 0.3933392806381091 1.0 0.5610514279040513 27 Q9H7B4,Q6P2P2,O60725 3 +Ubiquitin specific protease binding 0.4887577578911026 0.8370983711296562 0.4025372759221273 1.0 0.5700908628541803 9 P46379 1 +Oxidized dna binding 0.4982497049031682 0.8350302426876189 0.4037006807416325 1.0 0.5707660246731874 6 P52701,P18887,P43246 3 +Racemase and epimerase activity acting on carbohydrates and derivatives 0.4578105522650594 0.8347964843982018 0.4038323056289863 1.0 0.5707660246731874 4 Q9UL01 1 +Map kinase phosphatase activity 0.4069428238039728 0.8318044059289248 0.4055193565771016 1.0 0.5714136388131885 2 Q99956 1 +Flavin adenine dinucleotide binding 0.3712129939188129 0.8036355834497501 0.4216074663906366 1.0 0.5875548607541838 33 Q15392,A1L0T0,P49748,O00116,Q14534,P16435 6 +Phospholipase activity 0.4203462157953901 0.7885403299808857 0.4303807180397749 1.0 0.5956161722871885 18 P09601,Q8N2A8,Q8NCC3,Q8NHP8 4 +Peptidase regulator activity 0.3696980687827568 0.7766819762038096 0.4373464232148421 1.0 0.6028638936607753 32 Q9BXK5,P51812,P05067,Q15418 4 +Lipase activity 0.4034609880756689 0.7706209958521804 0.4409316125404006 1.0 0.6066071000925629 21 Q8N2A8,Q8IV08,P09601,Q8NCC3,Q8NHP8 5 +Proton transporting atp synthase activity rotational mechanism 0.4679341804169288 0.7485502977217929 0.454128298523738 1.0 0.6210872318045241 10 P24539,O75964,P56385 3 +Proton channel activity 0.4679341804169288 0.7485502977217929 0.454128298523738 1.0 0.6210872318045241 10 P24539,O75964,P56385 3 +Oxidoreductase activity acting on nad p h 0.3661762383135025 0.7351354424989106 0.4622570110103026 1.0 0.6297348929290744 31 Q13423,P03886,Q9P0J0,O43676,Q7KZN9 5 +Mdm2 mdm4 family protein binding 0.4769218573714179 0.731891596955321 0.4642347354782168 1.0 0.6318121521874267 6 P61289 1 +Atpase coupled cation transmembrane transporter activity 0.4426431157904797 0.7248066006739218 0.4685706858080367 1.0 0.6352343116639565 13 Q9HD20,P16615,P20020,P06576 4 +N acyltransferase activity 0.3949420620788609 0.7131434886764179 0.4757569711245195 1.0 0.6426973248978763 21 Q86UY6,P27544,O14929,O75448,Q96G23 5 +Chloride channel inhibitor activity 0.4093104512581386 0.71069829780007 0.4772712147138309 1.0 0.6428905485967046 3 O15400 1 +Long chain fatty acid transporter activity 0.4714934580953467 0.7059474840187783 0.4802207966554901 1.0 0.6429059609735208 6 O14678,P11166 2 +Nucleocytoplasmic carrier activity 0.3932925793379386 0.7020631162514854 0.4826398029474186 1.0 0.6436735421717485 21 Q9C0E2,Q92973,Q96P70,Q96QU8,P52292 5 +Deoxyribonuclease activity 0.3930961285959297 0.6797341799970232 0.4966727895733838 1.0 0.6592374324023504 20 Q8IV08,P28340,Q9UQ84,Q07864 4 +Nadh dehydrogenase activity 0.3828775821583313 0.6776812280038964 0.497973831249467 1.0 0.6603360214762419 23 O43676,P03886 2 +Phosphatidylinositol 3 5 bisphosphate phosphatase activity 0.3934294196737723 0.6272729895350918 0.5304803056327825 1.0 0.6896738363072988 3 Q01968 1 +G protein activity 0.4155266903009569 0.6221309902008323 0.5338557388168161 1.0 0.6927354167817069 14 P62820,Q15907,P61020 3 +Ionotropic glutamate receptor binding 0.4086542829713298 0.5860510503129086 0.5578412092850078 1.0 0.7172244119378671 4 P27824,O75955 2 +Metalloexopeptidase activity 0.3756100915832447 0.5845501207010935 0.5588502548059946 1.0 0.7174618892215493 21 P55786,O75844,Q9NZ08,Q9UIQ6 4 +Protease binding 0.354646432671856 0.583482041996469 0.5595688426330077 1.0 0.7174618892215493 27 P07602,Q9NZJ7,Q6NTF9,Q9BUN8,P46379,P42574 6 +Potassium channel inhibitor activity 0.3843011380216046 0.5802851224028812 0.5617223585856483 1.0 0.7189015506669536 3 Q96PU5,O43768 2 +Endopeptidase regulator activity 0.3534211860080763 0.5744141150053692 0.5656876035540246 1.0 0.7219892103914587 27 P05067,P51812,Q15418 3 +Tumor necrosis factor receptor binding 0.4057209573847106 0.571745855699454 0.5674941634516442 1.0 0.7229720164520946 4 P42224,Q9NXR7,Q12933 3 +Calcium ion transmembrane transporter activity 0.4133337012130159 0.5645015624580424 0.572412837106723 1.0 0.7273027976725933 13 Q9UM00,Q8NE86,P20020,P16615,O95202 5 +Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity 0.3585180863477231 0.5636695414963923 0.5729790499227096 1.0 0.7273027976725933 2 Q9Y217 1 +Cobalamin binding 0.403677758318745 0.5618280657587759 0.5742331681580164 1.0 0.7282320632549389 4 Q99707,P22033,Q9Y4U1 3 +Transforming growth factor beta receptor binding 0.4030939871570411 0.5590015998347112 0.5761606283388729 1.0 0.7300127852250025 4 Q9Y4E8,Q9UNH7,Q8WUH2 3 +Misfolded protein binding 0.3952098843207288 0.5558881130868041 0.5782873448025794 1.0 0.7320425099814866 15 P46379,Q9UBN7,Q9BUN8 3 +Phosphotransferase activity for other substituted phosphate groups 0.4193973381763219 0.5496694282492683 0.5825461292867851 1.0 0.7354315387828644 5 Q9H9S5,Q9NRN7 2 +Aminopeptidase activity 0.3938010093488719 0.5478541850209159 0.5837920294110273 1.0 0.7363380479460968 15 P55786,Q9NZ08,Q9UIQ6 3 +Phosphatase inhibitor activity 0.4346159425207226 0.5433100197115738 0.5869163666848132 1.0 0.738497717544475 7 Q01105,P17931,Q9Y570 3 +Translation initiation factor binding 0.3831674561836257 0.5307294890294757 0.5956062479975941 1.0 0.7447409710536959 17 P55010,P62847 2 +Trna guanine methyltransferase activity 0.4291496461166051 0.5280303242955855 0.5974782889486987 1.0 0.7461792417935852 8 Q7Z2T5 1 +Protein phosphatase regulator activity 0.366682326359971 0.526317714063162 0.5986674772733087 1.0 0.7462363928489856 21 Q6IN85,Q86XL3,P0DP25,P78318,P17931,Q9Y570,Q01105 7 +Co smad binding 0.3509334889148208 0.5237266624464916 0.6004686682837446 1.0 0.7472379948758463 2 Q93008 1 +Isopeptidase activity 0.4256065477930528 0.522515010736345 0.6013117978607365 1.0 0.7476202834364772 9 Q7L5N1,P51665,O95630,Q92905,O15372,Q6P2Q9,Q9H4L4,O00303 8 +Mannosyltransferase activity 0.4313056763393419 0.5194601422427266 0.6034399006681046 1.0 0.7489311934448452 6 Q9BT22,Q2TAA5 2 +3 hydroxyacyl coa dehydrogenase activity 0.4289684138842382 0.5173504557448951 0.6049115383381707 1.0 0.7500903075393317 7 Q53GQ0 1 +Nucleoside binding 0.4108029197080328 0.5097967980866168 0.6101938291308511 1.0 0.755297596838986 5 P30876,Q9H9Y6,Q9NW08,P00491 4 +Metal dependent deubiquitinase activity 0.4253578732106338 0.5009044219682064 0.6164383902765613 1.0 0.759841536273348 7 Q7L5N1,P51665,Q92905,O15372,Q6P2Q9,O00303 6 +3 5 dna helicase activity 0.4179058169381631 0.4860976325674842 0.6268979453739483 1.0 0.7698262621449453 9 P49736,P33993,Q8N3C0,Q14566 4 +Nadp retinol dehydrogenase activity 0.3841033725004522 0.4689759850164671 0.6390868016932756 1.0 0.7820404283878241 4 Q9Y394,Q8NBN7 2 +Cation channel activity 0.363016771323343 0.4592738306655437 0.646037537767461 1.0 0.7881050029561927 19 O75964,P56385,Q9UM00,Q8NE86,Q00535,P24539,P06576 7 +Ribosome binding 0.3185646135365125 0.4553591497529753 0.6488508788617369 1.0 0.7885963019875162 39 P42345,Q15070,Q9UM00,Q969V3,P46379,O95202,Q96A33 7 +Nadplus kinase activity 0.3590834724442854 0.4551888650759711 0.6489733705335674 1.0 0.7885963019875162 3 P52429 1 +Phosphatidylinositol monophosphate phosphatase activity 0.3586227020717957 0.4529784166492057 0.6505642832901757 1.0 0.7885963019875162 3 Q9NTJ5,Q9Y217 2 +Protein serine threonine kinase activator activity 0.4077485517701134 0.4494795240406229 0.653085775744926 1.0 0.7894754394836844 10 P0DP25 1 +Lysophospholipid acyltransferase activity 0.4125780472973694 0.4437238681331024 0.6572422368333362 1.0 0.7928079470929752 7 Q9NUQ2,Q8NF37,Q96N66 3 +Protein antigen binding 0.3351808634772443 0.443301704406806 0.6575475231444963 1.0 0.7928079470929752 2 Q96L91 1 +Dynein intermediate chain binding 0.4097217135287289 0.4388850334292453 0.6607448418449797 1.0 0.7959750037769834 8 P43034,Q14204,P42858 3 +N methyltransferase activity 0.3310291956844219 0.4378946781663264 0.6614626336140041 1.0 0.7961521776458462 28 Q9H7B4,Q6P2P2,Q7Z2T5 3 +Guanyl nucleotide exchange factor activity 0.3137501434732195 0.4304656028231488 0.6668569829472304 1.0 0.8012622663319435 40 P80303 1 +Tau protein kinase activity 0.407710280373848 0.4162790467735241 0.6772058232054277 1.0 0.8109031101901902 6 Q7L7X3,Q00535,O75116,Q7KZI7,Q13464 5 +Membrane insertase activity 0.4042501126016569 0.4074164033442856 0.683702181327414 1.0 0.8158807039792494 7 Q15070 1 +Metalloaminopeptidase activity 0.3891194033093573 0.4034587974436218 0.6866107396889316 1.0 0.8186512665521877 12 P55786,Q9UIQ6 2 +Insulin like growth factor receptor binding 0.3478260869565279 0.4020827205357902 0.6876231491242262 1.0 0.8186683379418591 3 P46108,P61981 2 +Inositol phosphate phosphatase activity 0.3689433741973218 0.4002106471364001 0.6890013732157472 1.0 0.8186683379418591 4 Q10713,Q01968,Q9UNW1 3 +Ubiquitin like protein conjugating enzyme binding 0.3883609606356503 0.3997873051367048 0.6893131817767391 1.0 0.8186683379418591 12 Q96GG9,Q92564 2 +Acyltransferase activity 0.30140588709839 0.3978535264849485 0.6907381586634944 1.0 0.8186743681695623 58 P49327,O15269,O15228,Q9NUQ2,Q86UY6,P27544,Q9H9T3,P23786,Q8NCC3,O14929,O75448,Q96G23,Q96N66 13 +Nad dependent protein deacetylase activity 0.3838890635476268 0.3900860802476361 0.6964728954953379 1.0 0.8226754354072788 5 Q9UBN7 1 +Iron ion binding 0.3316424443724508 0.3720343738407587 0.7098672566773141 1.0 0.8352202614821894 25 P22830,Q9NVH6,Q15800,Q16850,O00767,Q6UW02,O75845 7 +Nadplus binding 0.3956917454736068 0.3709793148207568 0.7106529385176215 1.0 0.8352202614821894 7 Q16836 1 +Gtp dependent protein binding 0.3942998408740632 0.3604397154540819 0.7185183310563628 1.0 0.8404687079207284 6 P61020 1 +Magnesium ion binding 0.2937395577688253 0.3601079216035734 0.718766429067691 1.0 0.8404687079207284 79 Q15382,Q969T7,A1L0T0,Q9NRN7,A8MXV4,P51812,Q9H2U1,Q15418,Q9H773 9 +Molecular carrier activity 0.3138741407937657 0.3545437109034811 0.7229314520533503 1.0 0.8432185414836318 34 P55060,Q9C0E2,Q92973,Q96P70,Q96QU8,Q9NPA0,P52292,Q15070 8 +Protein phosphatase 2a binding 0.3844103894966112 0.3520765100667398 0.724780884214091 1.0 0.844283853517501 11 P78318,Q86XL3,Q9Y570,Q96GX5 4 +Phosphoric ester hydrolase activity 0.2918367779621619 0.3441399571206134 0.7307410345978855 1.0 0.8480729977238355 75 Q8N2A8,Q969T7,Q9NPH0,Q8IV08,P09601,P11117 6 +Proteoglycan binding 0.3549132707263643 0.3395171961415578 0.7342201449466303 1.0 0.8514024124692846 4 O00560 1 +2 iron 2 sulfur cluster binding 0.3803161764722781 0.3336197768034116 0.7386664927649895 1.0 0.8547057638026446 11 P47985,P21912,Q9NZ45 3 +Lrr domain binding 0.3323606653049396 0.332506060919167 0.739507163859018 1.0 0.8547057638026446 3 Q9NY61,Q6P1K2 2 +Leucine zipper domain binding 0.3323606653049396 0.332506060919167 0.739507163859018 1.0 0.8547057638026446 3 Q9NY61,Q6P1K2 2 +Acetylglucosaminyltransferase activity 0.3873590232374881 0.3324660618404715 0.7395373623385963 1.0 0.8547057638026446 6 O43505 1 +Trna methyltransferase activity 0.3798729316043688 0.3316367800165407 0.7401635434237293 1.0 0.8547057638026446 11 Q7Z2T5 1 +Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor 0.3238192178529116 0.3205491980520876 0.7485520415020912 1.0 0.8608657031289507 25 O43676,P03886 2 +Amidine lyase activity 0.3493870402802171 0.3164867350100118 0.7516330920698286 1.0 0.8633391555906534 4 O75592,O75223,Q8WUX2 3 +Nad retinol dehydrogenase activity 0.308343057176194 0.3160816231193081 0.7519405548692788 1.0 0.8633391555906534 2 Q8TC12 1 +Endoribonuclease activity 0.3248035723303955 0.309545089388517 0.7569069187447439 1.0 0.8683266049744389 24 Q9UQ84 1 +Oxidoreductase activity acting on a sulfur group of donors 0.3244680212233777 0.307427811570074 0.7585177619131007 1.0 0.8690536540588787 24 O95881,O43396,Q9UHG3,P78417 4 +Protein serine kinase activity 0.2892942600012538 0.3070745465079955 0.7587866312858167 1.0 0.8690536540588787 81 P54646,Q13546,P42345,Q13535,P11802,P50750,P06493,Q13315,P78527,Q00535,P51812,P48729,Q15418,O14965,Q96GX5 15 +Nuclear import signal receptor activity 0.3617373681692107 0.303395060811337 0.7615888093061105 1.0 0.8694078469574665 13 P52292 1 +Nf kappab binding 0.3471558413877382 0.2962806180041198 0.7670157864259479 1.0 0.8734587935217938 15 Q86UE4 1 +Phosphatidylinositol bisphosphate phosphatase activity 0.3588321167883258 0.2874340366937218 0.7737800027095809 1.0 0.8793445224647574 5 Q01968,Q9Y217,Q96PE3,Q10713 4 +Protein tyrosine serine threonine phosphatase activity 0.3588321167883253 0.2874340366937197 0.7737800027095825 1.0 0.8793445224647574 5 Q9UNI6,P51452,P49593,Q99956 4 +Rna polymerase ii c terminal domain binding 0.3403385872737953 0.2799461068108276 0.7795188527332977 1.0 0.8807771454216078 4 Q00839,O60885,Q92541 3 +Beta tubulin binding 0.3266949378916551 0.2796368779899821 0.77975611082128 1.0 0.8807771454216078 21 P42858,O14737,Q9UBK9,O75381,Q9UBN7 5 +Protein self association 0.36672564371202 0.2742497650788426 0.783892686573616 1.0 0.8811686525142581 11 Q9BTV4,P11166,Q9Y282 3 +Glutamate receptor binding 0.3701230696530162 0.2682233494840337 0.7885274029976996 1.0 0.8856648367003147 7 P0DP25,O75955,Q15334,P27824 4 +Carboxylic acid binding 0.2970820146031028 0.2650516700077043 0.7909696578394791 1.0 0.8876932201818772 38 Q9UM22,Q13277,P07602,Q9NZJ7,P00374 5 +Keratin filament binding 0.3154362416107533 0.2615799684409999 0.793645289289211 1.0 0.8899800470727084 3 P08670,P58107 2 +Protein deacetylase activity 0.3676041491675612 0.2567643035670459 0.7973607280171859 1.0 0.8927112484622587 6 Q9UBN7 1 +Carbon nitrogen lyase activity 0.3494890510948959 0.2517948043306531 0.8011996735070825 1.0 0.8962899314694308 5 O75592,O75223,Q8WUX2,Q9HDC9 4 +Fibroblast growth factor binding 0.3589584433007668 0.2256437704234459 0.8214784947887022 1.0 0.9120419321896794 6 Q99584 1 +Proteasome binding 0.3440453173711879 0.223420850678421 0.8232079779355612 1.0 0.9128578133705152 13 O76024,O95456,Q92530,P46379,Q5VYK3 5 +Enzyme activator activity 0.2718144973839655 0.2179002302933573 0.8275068477092036 1.0 0.9168959909089268 121 Q01968,O43169,Q9P035,P14635,P61289,P42574,O60343,Q9H8V3,Q9HCU5,P0DP25,Q15057,Q96QE5,Q4KMP7,Q9BXK5,O14737,Q15042,P07602,Q5JRX3,Q99735,Q8IYB5,P05067,O75569,P17900,Q6IN85,P10619,P35269,Q9NZJ7,Q66K14 28 +Glycosaminoglycan binding 0.322313089380436 0.2116920316744159 0.8323473050250005 1.0 0.9200669496908684 18 P05067,O14737,Q53GQ0,P47914,P15586,P43034 6 +Growth factor receptor binding 0.3288936938704078 0.2081314914415388 0.8351262989167159 1.0 0.921678154263306 15 O00560,P05067,Q9NZ08,P18085,O60749,Q92542 6 +Carbohydrate binding 0.2839936560778471 0.1959143548492472 0.8446772014508719 1.0 0.9280389930067464 47 P35613,P49257,P13674,P17931,Q8N4A0,Q16706,Q04446,Q10472,Q10471,P27824,P35573,P10253,Q12907,P52789,Q32P28,Q13438,O75503,Q9NPA0,O75592 19 +Cysteine type endopeptidase activity 0.3031501394678648 0.1914771538762854 0.8481517779516017 1.0 0.9297590519437868 25 Q70CQ2,O43292,Q13867,Q14674,P42574,Q9UPU5 6 +Phosphorus oxygen lyase activity 0.2967610154654291 0.1906617837094435 0.8487905815518522 1.0 0.9297590519437868 3 O00584,Q9NZB8 2 +Glutathione peroxidase activity 0.3368835479929603 0.1512452754836334 0.8797822363870458 1.0 0.95435164833587 7 O43708,Q8TED1 2 +Protein serine threonine tyrosine kinase activity 0.2752046389838022 0.1433821731772984 0.8859883612430894 1.0 0.958846985208774 85 P54646,Q13546,P42345,Q13535,P11802,P50750,P06493,Q13315,P78527,Q00535,P51812,P48729,Q15418,O14965,Q96GX5 15 +Double stranded telomeric dna binding 0.33323598130842 0.1412709052143979 0.8876559333506655 1.0 0.9598745904416686 6 P27695,P13010,P12956,Q92878,Q15554 5 +Peptidyl proline dioxygenase activity 0.3164963503649691 0.1395669821714343 0.8890021296420327 1.0 0.9598745904416686 5 P07237,O15460,P13674,Q32P28 4 +Retromer complex binding 0.309781021897815 0.1195904211458619 0.9048076080818022 1.0 0.9739248559213842 5 Q99523,P20645,P11717,P51149 4 +Microfilament motor activity 0.3263157894736891 0.1170045149674848 0.90685647563257 1.0 0.9753776279933964 10 P35579,O94832,Q12965,O00159,O43795,P60660,Q7Z406,P35580,Q9UM54 9 +Lys48 specific deubiquitinase activity 0.3235981308411277 0.1130959682580174 0.9099544713497576 1.0 0.977955691473738 6 Q9H8M7,Q9Y4E8,Q93009,Q6GQQ9,Q93008 5 +Kinase regulator activity 0.2701199676019689 0.08646472555892 0.9310969959507144 1.0 0.997603924232908 49 O95067,P11802,O95684,P14635,P0DP25,Q9H9T3,A4D1P6,P54619,P42574 9 +Histone lysine n methyltransferase activity 0.304129204847908 0.0832662648939504 0.9336398238296676 1.0 0.9987941366889468 14 Q9H7B4 1 +Lysine n methyltransferase activity 0.304129204847908 0.0832662648939504 0.9336398238296676 1.0 0.9987941366889468 14 Q9H7B4 1 +Structural constituent of postsynapse 0.277875072971402 0.0756162453153015 0.9397244115756728 1.0 1.0 4 Q15334,Q16352,P07196 3 +Carbon carbon lyase activity 0.2865703063337207 0.0740173885255593 0.9409965491701716 1.0 1.0 22 O95470 1 +Phosphatidylinositol 3 5 bisphosphate binding 0.3112012688024111 0.073442186538145 0.941454248212102 1.0 1.0 8 Q9Y5X3 1 +Mismatched dna binding 0.2767353786871238 0.0727677679204464 0.9419909204080564 1.0 1.0 4 P52701,P43246 2 +Dna insertion or deletion binding 0.2767353786871238 0.0727677679204464 0.9419909204080564 1.0 1.0 4 P52701,P43246 2 +Polyubiquitin modification dependent protein binding 0.291200481506874 0.0678671420746078 0.945891395249708 1.0 1.0 18 Q9NXR7,P54725,Q9UBN7,Q96S82,P46379 5 +Peptide lysine n acetyltransferase activity 0.3097318726098813 0.0649709416945829 0.9481971365243732 1.0 1.0 11 O75448,Q86UY6 2 +Dna clamp loader activity 0.3048891203510303 0.0601397761437741 0.9520443104967238 1.0 1.0 7 P35251,Q8WVB6,P0CG13 3 +Cis trans isomerase activity 0.279584594602466 0.0601150257787035 0.952064022765736 1.0 1.0 25 Q9NWM8,O95302,Q96AY3,Q9Y680 4 +Vitamin binding 0.266089151217112 0.0537799727384952 0.9571104658634746 1.0 1.0 49 O95470,P38435,P00374,P04062 4 +Peptide n acetyltransferase activity 0.2990351709802358 0.0519303240844479 0.9585842117418436 1.0 1.0 13 O75448,Q86UY6 2 +Cell cell adhesion mediator activity 0.27420004079542 0.0069352590603968 0.9944665082287236 1.0 1.0 19 Q99959,Q9UQB8 2 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..c87fa2753f5b47a378f2adf96a14350c3e60a62b --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 3 kinase regulator activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "3 phosphoadenosine 5 phosphosulfate binding", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5alpha androstane 3beta 17beta diol dehydrogenase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenosine receptor binding", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminoacyltransferase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Angiotensin receptor binding", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Ap 2 adaptor complex binding", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbohydrate transmembrane transporter activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Chloride transmembrane transporter activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Connexin binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Crossover junction endodeoxyribonuclease activity", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclase regulator activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase inhibitor activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase activity involved in apoptotic process", "Cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D glucose transmembrane transporter activity", "D loop dna binding", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Dehydroascorbic acid transmembrane transporter activity", "Delta catenin binding", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix constituent conferring elasticity", "Extracellular matrix protein binding", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Fatz binding", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Filamin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate binding", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H3 histone acetyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Icosanoid binding", "Identical protein binding", "Ige binding", "Igg binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol bisphosphate phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate kinase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor i binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide 1 2 alpha mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular sequestering activity", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Mutsalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin light chain binding", "Myosin v binding", "Myristoyltransferase activity", "N acetyllactosamine synthase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus nucleosidase activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nadplus nucleosidase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neuregulin binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neurotransmitter binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on metal ions", "Oxidoreductase activity acting on metal ions nad or nadp as acceptor", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced ascorbate as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreductase activity acting on the ch nh2 group of donors oxygen as acceptor", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 4 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphorylation dependent protein binding", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase 2b binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein sequestering activity", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Selenium binding", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sugar transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syndecan binding", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Triglyceride lipase activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor binding", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor activated receptor activity", "Vascular endothelial growth factor binding", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Wnt protein binding", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Y form dna binding", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADO", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APBB1", "APEH", "APEX1", "API5", "APIP", "APMAP", "APOL2", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL15", "ARL2", "ARL3", "ARL6IP1", "ARL8A", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "AS3MT", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATR", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS3", "BCAT1", "BCAT2", "BCCIP", "BCKDHB", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BECN1", "BEND3", "BICD2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRD8", "BRIX1", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "C2CD2L", "C2CD5", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CD3EAP", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CENPV", "CEP250", "CEP290", "CEP44", "CEP55", "CEP97", "CERS1", "CERS2", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHM", "CHMP5", "CHORDC1", "CHRAC1", "CHTF18", "CHTF8", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT4", "CNOT7", "CNP", "COASY", "COIL", "COLGALT1", "COMMD7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC22", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENND5B", "DENR", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSE", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFCAB14", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "ENSA", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM105A", "FAM120A", "FAM129B", "FAM208A", "FAM20B", "FAM213A", "FAM49B", "FAM50A", "FAM83D", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FSD1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GID8", "GIGYF2", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP6", "GTPBP8", "GTSE1", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS4", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK1", "HP1BP3", "HPF1", "HPRT1", "HS1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INPPL1", "INTS11", "INTS6", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRGQ", "IRS4", "ISCA2", "ISG20L2", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JMJD6", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LLGL1", "LLPH", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT4", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC14", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRRC8A", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MACF1", "MAGED1", "MAGT1", "MAIP1", "MAK16", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCRS1", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL13", "METTL25", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOCS2", "MOCS3", "MOGS", "MORC2", "MORC3", "MORF4L1", "MOV10", "MPC2", "MPDZ", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL4", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG1", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NET1", "NEU1", "NF1", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NMD3", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OTULIN", "OXA1L", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNT", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEBP1", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF6", "PHGDH", "PHIP", "PHLDB2", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLEKHA7", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "PON2", "POP1", "POR", "POU2F1", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIBP1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REL", "RELA", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTF1", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SACS", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SCYL2", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SH3RF1", "SHCBP1", "SHMT1", "SHMT2", "SHPRH", "SHTN1", "SIGMAR1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SLU7", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMYD3", "SMYD4", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPNS1", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRA1", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSRP1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAB1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TENM3", "TERF2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFRC", "TGFBRAP1", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TM7SF2", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM201", "TMEM43", "TMLHE", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSPYL1", "TSR1", "TST", "TSTA3", "TTC1", "TTC26", "TTC28", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBL7", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VMP1", "VPS16", "VPS18", "VPS25", "VPS28", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS72", "VRK1", "VRK2", "VRK3", "WARS", "WASF2", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WLS", "WNK1", "WRAP53", "WTAP", "WWP2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO6", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YES1", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMAT2", "ZMPSTE24", "ZMYM2", "ZMYM3", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "AATF", "ABCB1", "ABCB8", "ABCD4", "ABHD10", "ACADVL", "ACAP2", "ACOX1", "ACOX3", "ACP2", "ACP6", "ADK", "AGL", "AGPAT5", "AGPS", "ALDH3A2", "ALG1", "ALG11", "ALKBH5", "ANKLE2", "ANO6", "APEX1", "APMAP", "APOL2", "APP", "ARF4", "ARFIP1", "ARSA", "ASCC3", "ASNA1", "ATG9A", "ATIC", "ATM", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATR", "AURKA", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BAX", "BCL2L13", "BLMH", "BRD4", "BSG", "C1QBP", "CALM3", "CANX", "CARM1", "CASP3", "CCDC47", "CCNB1", "CCNB2", "CDK1", "CDK4", "CDK5", "CDK9", "CERS1", "CERS2", "CETN2", "CHAC2", "CHRAC1", "CHTF18", "CHTF8", "CISD1", "CLCN7", "CLN5", "CLPP", "CNNM3", "CNNM4", "COPS5", "COPS6", "COX15", "COX2", "COX4I1", "COX6B1", "COX7A2", "CPT2", "CPVL", "CRK", "CSE1L", "CSNK1A1", "CTSA", "CYB5B", "CYB5D2", "CYP20A1", "CYP51A1", "DCTPP1", "DCUN1D1", "DCUN1D4", "DERL1", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHX36", "DNM2", "DSE", "DUSP12", "DUSP3", "DUSP9", "DYNC1H1", "ECE1", "ECT2", "EFCAB14", "EHD4", "EIF3F", "EIF3H", "EIF5", "ELP3", "EMC7", "ENSA", "EP400", "EPDR1", "EPPK1", "ERAP1", "ERGIC3", "ESPL1", "EXO1", "FADS2", "FAM49B", "FASN", "FCGRT", "FDFT1", "FECH", "FGFR1OP", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FKRP", "FLOT1", "FNTA", "FNTB", "FOXRED1", "FUCA2", "GAA", "GALNT1", "GALNT2", "GALNT4", "GBA", "GBE1", "GGCT", "GGCX", "GGH", "GLB1", "GM2A", "GNPAT", "GNS", "GOLGA5", "GOLPH3", "GOSR1", "GPAA1", "GPD1L", "GPX8", "GSTA4", "GSTO1", "GSTZ1", "GTF2F1", "H1F0", "HACD3", "HADH", "HAT1", "HDAC6", "HK2", "HLA-B", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMOX1", "HMOX2", "HNRNPU", "HSD17B12", "HSDL1", "HTT", "ICMT", "IDE", "IGBP1", "IGF2R", "ILVBL", "INA", "INPP4A", "IPO9", "IRS4", "ITM2B", "ITM2C", "KDELR1", "KDELR3", "KDM1B", "KDSR", "KIAA0368", "KIF3A", "KMT2A", "KPNA2", "LBR", "LETM1", "LGALS3", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LPCAT1", "M6PR", "MAN2A1", "MARK2", "MASTL", "MBOAT7", "MCL1", "MCM2", "MCM6", "MCM7", "MCU", "MED24", "MFSD10", "MFSD3", "MGEA5", "MGST2", "MICU2", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MMACHC", "MOCS1", "MSH2", "MSH6", "MSMO1", "MTAP", "MTCH1", "MTDH", "MTMR6", "MTOR", "MTR", "MUT", "MYCBP2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO6", "NAA40", "NAGLU", "NAMPT", "NCLN", "NCSTN", "ND1", "NDUFA13", "NDUFA8", "NDUFAF7", "NDUFB3", "NDUFB9", "NEDD4", "NEDD4L", "NEFL", "NENF", "NNT", "NOB1", "NPC1", "NPEPPS", "NT5C2", "NT5C3B", "NUCB1", "NUCB2", "NUDT19", "NUDT5", "OCRL", "OS9", "OSBPL1A", "OSBPL8", "OTUD7B", "OXA1L", "P3H1", "P4HA1", "P4HA2", "P4HB", "PAFAH1B1", "PAFAH1B2", "PAK2", "PARP1", "PARP2", "PCYOX1", "PDCD5", "PDK3", "PEX14", "PGRMC1", "PGRMC2", "PI4K2A", "PIGK", "PITRM1", "PKP2", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PLXNB2", "PMF1", "PMPCA", "PNP", "POLD1", "POLE", "POLE3", "POLE4", "POLR1B", "POLR2B", "POLR3B", "POMGNT2", "POR", "PPM1F", "PPME1", "PPP1R12A", 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0.2501622891395578 2.541375726543966 2.628804376839775 1.8399520883426277 0.3043503409762604 0.0856229888655945 0.2560754722464486 0.0198486300115185 0.0005812813538685 0.0005781925850387 +Abnormal retinal artery morphology 7 22 2.5535590594389923 0.0106628193662718 6.985436893203883 21.733009708737864 0.6882820766413594 0.2247118762866906 2.318097134221824 2.0518941450352677 1.8438290687413053 0.2835525492265039 0.0623838765901622 0.2183837422916212 0.0121763996061805 0.0001846255682835 0.0006053327615549 +Endocarditis 3 5 2.546803843204533 0.010871452351121 1.6699029126213591 5.055825242718447 1.0315066990472646 0.3137673633075574 1.128951309195931 0.7031759081548564 0.9300019606367588 0.2935479974969262 0.0934764824591146 1.0 0.1094892401774078 0.2550529546148332 0.0182159139614431 +Bulbar signs 7 13 2.5434216948634667 0.0109772658547664 4.888349514563107 12.016990291262136 1.527818207801298 0.1656113111527082 2.218011046873564 1.4803576942139227 1.2783367300196684 0.2344360472575242 0.0021760960656691 0.1457663642848915 0.0002347353167816 0.0009447024772989 0.0001122473104027 +Limb undergrowth 16 60 2.538078518859734 0.0111462973561964 10.648058252427184 51.10436893203884 0.3980398713744312 0.5752346762319336 4.664982243954684 7.303495661229484 0.9215304205365352 0.3350258300048305 0.0608969678898302 0.0595462588150643 0.0979989328881401 0.1532147512154899 0.0075649948066216 +Insidious onset 1 5 2.526806166269775 0.0115105011307123 1.5606796116504855 4.798543689320389 1.010752209781939 0.2963577845750634 1.0233713199598442 0.8899098980975658 0.9610714276026808 0.2642783107441792 0.1081933924999157 1.0 0.1265462710440741 0.290751966651369 0.1467539296032722 +Neurofibrillary tangles 2 6 2.515024016995727 0.0119024275291452 1.9878345498783456 4.347931873479319 0.5966090900062281 0.2642083372508564 1.0995898071170882 1.1496807364853057 1.4348037417662018 0.2714513638042118 1.0 1.0 1.0 0.0041946485896371 0.0280386150660574 +Pericardial effusion 3 7 2.502798848817944 0.0123215551257613 1.9466019417475728 5.980582524271845 0.6333430474464145 0.2773316461993735 1.2136213588737947 1.4646685732948297 1.3006352977804805 0.2635985168358294 0.0136086826932428 0.1026081339138497 0.018640880521655 0.0017432511761074 0.020271757680103 +Long toe 1 10 2.4901917467284247 0.0127674193630122 2.0509708737864076 9.45631067961165 0.5785940019712174 0.5046426078252286 1.608479964210984 1.1619092007798284 0.7950670706550987 0.3062114383050053 0.0160900301160464 0.1114073342812727 0.0219975904219434 0.1139407547181512 0.3280048671308403 +Abnormal csf protein level 8 13 2.475129829029988 0.0133187749735548 4.434466019417476 12.20631067961165 1.1239853500963992 0.2260559983233297 2.11400242863219 2.084072511592451 1.241935948510828 0.248039542652958 0.2733967462722031 1.0 0.0538434207197609 0.0142235096743441 8.252659237109036e-05 +Abnormal myocardium morphology 39 186 2.4698841206714426 0.0135156825976352 39.25970873786408 168.2597087378641 0.3575832300862268 0.6390291398034755 13.965214340125677 16.3501737739829 0.9922765990658236 0.3661562236284471 0.0551106598858521 0.0542903881668313 0.0492822266858241 0.0067336704689934 3.0114120478267667e-06 +Psychomotor deterioration 4 9 2.4680930793489324 0.0135834993635386 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 0.0048180551758565 1.0 0.0002296483500821 8.796898694645245e-06 0.0002504856541451 +Progressive neurologic deterioration 10 21 2.441656450360873 0.0146200520309511 6.75 20.466019417475728 0.5813429756502071 0.2930928839947513 2.6727908035631316 1.300228015706032 1.5791549964390388 0.3142214461904322 0.0050775930259089 0.1908924307699622 0.0080456420559546 0.0005468287448316 4.590361996766185e-06 +Abnormal aortic valve morphology 11 43 2.416758829427047 0.0156593886084446 8.643203883495145 40.00970873786408 0.3771375227817258 0.6013013640738508 3.3791734249815333 4.169922691726094 0.7682658177529654 0.3210565311311592 0.0213880457941844 0.1332928413805449 0.0363983757034302 0.0958642022468623 0.0246559918080744 +Increased bone mineral density 9 27 2.4107136912458813 0.0159213413862557 6.242718446601942 24.75 1.1480702818250033 0.3148175930983396 2.4533156459354677 2.2345749579547443 1.0849696139569316 0.312718333498069 0.0033575894968213 0.0533785743764077 0.0060698672163979 0.0368512438420236 0.0036518848204098 +Renal agenesis 14 55 2.4070945462047417 0.0160800063515185 11.104368932038836 52.58495145631068 0.3515217416182281 0.6544780729142105 5.336381845754198 5.2951770277229695 0.7079887182546287 0.3091424091849951 0.0265537390997117 0.0305051812830626 0.0447466679201601 0.0196856428380044 0.0031313536025979 +Abnormal pulmonary interstitial morphology 10 35 2.404467990365404 0.0161960245391026 6.371359223300971 30.5995145631068 0.4103689768813533 0.4555813960836699 3.330566746297264 2.186076806332745 1.1224431747517174 0.329794447909787 0.0281740632520034 0.0597604037758126 0.0428883183388871 0.0136037852653257 0.0057895334881982 +Ventricular arrhythmia 11 43 2.4039182109242274 0.016220401870435 10.0 36.96601941747573 1.0415384316890377 0.3677574027458479 3.8522468541414527 4.8022861343455805 1.0152201826292362 0.3231502492090489 0.5637945515640705 1.0 0.2533609509960167 0.0030790050493254 0.0036074014716307 +Personality changes 5 16 2.392638147573945 0.0167277294293641 4.235436893203883 16.20873786407767 0.716641708966708 0.4361664780008399 2.2513009299259603 2.2727002372019856 0.9467269936740988 0.3182188186141179 0.2674108336121077 1.0 0.0513963234576887 0.063688713570506 0.0095095891823194 +Abnormal pericardium morphology 6 12 2.3723588155835524 0.0176749166623066 3.487864077669903 10.762135922330096 1.0304485268572945 0.2849705132346721 1.7172308655515107 1.695717994097398 1.0794817436655069 0.2735310781030822 0.0310394603318191 0.1541506060207377 0.0420348553288257 0.0088087297166582 0.0054583584483833 +Narrow iliac wing 0 5 2.370524398425319 0.0177628715227209 1.4296116504854368 3.8033980582524274 -0.1744775351061762 0.5274958568876678 0.9963023114429658 0.7123652022350986 0.9508111368268222 0.3086827710758455 0.0556262242335954 0.0338360956076009 0.0653907127050202 0.1577810442013011 0.295251642909297 +Malar prominence 0 5 2.364139869096263 0.0180719882000615 1.5485436893203883 2.924757281553398 -0.3811051579641389 0.534182561306747 0.934803242645304 0.7923595641827221 0.9537737232870516 0.3138986917031902 0.0478709038219733 0.0290719737908623 0.0563150378970086 0.1368589802283267 0.2591162943571684 +Abnormal heart valve morphology 17 82 2.3607201213763416 0.0182394901846769 17.83252427184466 77.13106796116504 0.4699099631595928 0.6096529829544438 6.02733340682127 8.717091003223958 0.8450929313560487 0.3556463006581863 0.0629815602618123 0.13795486567134 0.1089652119169875 0.306120005000176 0.2133907796787597 +Thoracic kyphosis 2 18 2.353104471057545 0.0186174026253316 3.849514563106796 15.725728155339803 0.7266071624304212 0.4267138621860136 1.957478752201897 1.77496566461622 0.8648337345468261 0.3040731381323691 0.0030601380286973 0.1624541869963563 0.004885623522166 0.0558093330619567 0.2554523730097116 +Stroke like episode 3 5 2.3493523705655543 0.0188061000592494 1.9320388349514563 5.347087378640777 0.7802983779647638 0.3377286829697849 1.3402806250303152 1.5433591727314462 1.1185957061594276 0.2970042406174105 1.0 1.0 0.1515272625734178 0.062605312422627 0.0079931710216612 +Schizophrenia 10 23 2.342278152582794 0.0191664247702154 5.444174757281553 19.50242718446602 0.9817145874838714 0.3473822480141803 2.400301366302062 2.641618717487706 1.084663392230114 0.3211478296747099 0.0044373898287515 0.1828652209005429 0.0070463522145746 0.016869226769582 0.0001250677426663 +Abnormal nasal mucosa morphology 2 7 2.33916275431798 0.0193270118927764 0.9951456310679612 3.029126213592233 0.5238599989093575 0.4513344844257824 0.947646921342256 1.2303311629304916 1.1326671108301385 0.3296055235905867 0.1783105780413945 1.0 0.2070995190727305 0.0195244436529747 0.1093101132411038 +Capillary hemangioma 3 8 2.336699302865209 0.0194548248220121 2.533980582524272 7.133495145631068 1.1471796350867234 0.2683759543048971 1.4112277515033682 1.3471092449900268 0.9767941621718578 0.2786452679412407 0.2367426782920286 0.1499686155438198 0.2732850813359189 0.1899587232036964 0.0747991773170861 +Mucosal telangiectasiae 5 9 2.330403723503463 0.0197848231652066 3.2354368932038833 9.689320388349516 0.8501086222195428 0.291727970426265 1.410916714116348 1.5996305775803197 1.2598794700933909 0.2907637890882055 1.0 1.0 1.0 0.1467432355955838 0.0019580681099174 +Abnormality of corneal stroma 5 14 2.324959407350068 0.0200741308585548 4.733009708737864 13.131067961165048 0.6716440045814968 0.2233795964932449 1.7589100966397004 2.506749302052849 1.61853564814875 0.2527544669587041 0.0831940720909641 0.2523879312119707 0.1100932826860655 0.0138556470380734 0.0238799220201886 +Neuronal loss in central nervous system 5 11 2.3180476335743623 0.0204467324269432 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 0.0245754818920448 1.0 0.0334071197556988 0.0056128198685199 0.0028413691736374 +Abnormality of glycolipid metabolism 5 8 2.2995154489107708 0.0214756871390116 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 0.0785196824488724 1.0 0.0921025797166938 0.001485709034831 2.312503759377148e-06 +Proportionate short stature 11 35 2.294321378821115 0.0217720454523597 8.20873786407767 34.116504854368934 0.7111768198576495 0.4559300049156646 3.388318218343798 3.7920483254309434 0.966379822462628 0.3393663702605685 0.2164712900591845 0.0966324665930835 0.2747845331601694 0.1179506058012683 0.0057681272960385 +Muscle stiffness 4 19 2.294278843200337 0.0217744870290346 5.109223300970874 19.216019417475728 1.2530133657268057 0.2695837776665858 2.5817154639007844 2.4582801786037667 1.0397164239726309 0.2961148999712332 0.0100666740230864 0.237457799625543 0.0157478410048603 0.0104048104957299 0.1287911185788367 +Sensory ataxia 1 5 2.2923238135671604 0.0218869646710462 1.0946601941747574 4.475728155339806 0.90365564949505 0.3273813679316174 0.9128375854156834 0.6980508256758201 0.971845594745156 0.277174718697645 1.0 1.0 1.0 0.1577810442013011 0.0423042030727838 +Progressive gait ataxia 4 12 2.2901291492171363 0.0220138310633803 3.3810679611650487 11.0873786407767 0.9190295749650902 0.2658532875386696 1.7592835107251577 1.880439920211323 1.2434873962438642 0.2734996669217905 0.1715513885376269 1.0 0.1993869387044997 0.0173886328284286 0.0043704316922178 +Posterior fossa cyst 1 5 2.2890849967902405 0.0220744143663318 0.808252427184466 2.5728155339805827 0.7096929011433214 0.3745794382476462 0.8445311529596474 1.1749979694059942 1.381091073667821 0.3121366974203809 0.0860283086388496 0.0526645480715484 0.1008375048293403 0.2365379696877526 0.0974859568290139 +Hypoketotic hypoglycemia 3 7 2.2883813612366226 0.0221153221148335 2.3470873786407767 7.560679611650485 1.365087782487965 0.212332843161917 1.4324316558480732 0.6923349575659244 0.8002406012991511 0.2265642620801705 0.0860283086388496 1.0 0.1008375048293403 0.0020064706347618 0.0013990642028563 +Congenital nonbullous ichthyosiform erythroderma 0 5 2.286253214573557 0.0222394492131219 0.9781553398058253 3.9927184466019416 0.4055816504656483 0.5030421110644205 1.0575702575507464 0.5681219173387819 0.8690005948138257 0.2920983303866526 0.0556262242335954 1.0 0.0653907127050202 0.1577810442013011 0.295251642909297 +Abnormal circulating cholesterol concentration 13 34 2.284031134518558 0.0223697012260557 9.691747572815531 31.70873786407767 0.976903841313624 0.2790879029908041 4.4525142732793395 3.04459115485426 1.5883623188049951 0.3063455707490317 0.0230810279302175 0.0521335433076176 0.0353550186833354 0.0095088070763824 5.906319771660951e-05 +Corneal erosion 2 5 2.278336555307439 0.0227065332786902 1.2233009708737863 4.177184466019417 0.7910414476205148 0.3878014540608661 0.8582216749751288 0.7975471103055628 0.8908109698603051 0.2858661110419254 0.1226742139485862 1.0 0.1432798584585485 0.3247468214281712 0.5507460232908605 +Reduced visual acuity 30 124 2.2769955622775577 0.0227864906240127 25.553398058252423 114.88106796116504 0.4786956822479749 0.5063280215354549 8.433035081523723 11.838637206126975 1.2158495541746812 0.3830713742278179 0.0214188437866224 0.0257136443113427 0.0172328990604978 0.0738458624380283 0.0013516464101542 +Hypocholesterolemia 6 9 2.273534042462043 0.0229940170730633 3.2645631067961167 8.048543689320388 1.205673434171466 0.2055905154190861 1.747510449264718 1.0646904903887575 1.232151298114248 0.2464368010987078 0.100864684735291 1.0 0.1180585699575878 0.0002022933287296 8.329520797212374e-07 +Pedal edema 1 7 2.27353037716157 0.0229942376838248 2.092233009708738 7.211165048543689 0.6115824815809859 0.289867756561444 1.3297338459429695 1.219410808682535 1.3115580791228945 0.2762999280116011 0.0187491014912179 0.1201219647894398 0.0255840399150975 0.1300982938321277 0.3640245481081547 +Pericarditis 2 5 2.273411782630613 0.0230013767618963 1.5412621359223302 4.808252427184466 1.0465356013883245 0.3273693330411259 1.0523881114446327 0.8152847226576512 0.8192491618381674 0.278983410545408 1.0 1.0 1.0 1.0 0.1467539296032722 +Obsessive compulsive trait 0 5 2.2675634189634324 0.0233558294167561 1.058252427184466 4.718446601941747 0.3404953128582698 0.3777736884452908 1.1066896559256998 0.5731445492483667 1.1547313079382495 0.2847027325793588 1.0 1.0 1.0 0.2550529546148332 0.4511907478135378 +Ventricular preexcitation 3 6 2.263664573845196 0.023594752946016 2.5145631067961167 6.497572815533981 0.9841118497305948 0.2225227126053997 1.468861772329754 1.5757549992030588 1.3097679632537274 0.2453287763295943 1.0 1.0 0.1677870330809631 0.0102137155300364 0.0120515986398723 +Focal segmental glomerulosclerosis 3 22 2.254972830507365 0.0241350342194772 5.546116504854369 21.611650485436893 0.6827474585317643 0.4280798303492368 2.9461690553889595 2.0180400455423047 1.030587218054049 0.3284604148463202 0.0496923416317891 0.1948770046367652 0.0085749794431607 0.0213813720021448 0.1653068273939545 +Dysostosis multiplex 2 10 2.250685088116734 0.0244054898976255 3.983009708737864 7.990291262135922 0.4150973501220912 0.1595724105588133 1.65382835361071 1.246316090990369 1.8479195153421644 0.2123242141003258 0.157867792113085 0.0981765691424607 0.1837383274168749 0.0135296171343662 0.0798154053066686 +Abnormal femoral neck morphology 10 39 2.243479386662928 0.0248659176607721 9.25242718446602 36.74029126213592 0.6712343390867015 0.4697291762664369 3.621586968033212 4.796644044529848 0.9043918120717824 0.3346762025558714 0.0539615299706925 0.093603257631803 0.0183313093591291 0.1112177727483601 0.013126082022681 +Periventricular white matter hyperintensities 6 10 2.2384003641303374 0.0251949583158657 2.978155339805826 8.604368932038835 0.7206271937008832 0.2495118997135797 1.313488091366194 1.3113693798075805 1.4898193087366574 0.2872267653893681 0.1154630790463651 1.0 0.1349531130589082 0.000371706641515 4.468336037942089e-05 +Disproportionate short limb short stature 9 24 2.237629283940256 0.0252452402548348 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.1057846124719042 0.0437266531990119 0.1388614812827933 0.0242455864981032 0.0015738324289291 +Short femur 1 5 2.234110030905516 0.0254758341626459 1.5364077669902914 5.419902912621359 0.3480595482817972 0.5201386508470084 1.231123375525344 0.5581627196812791 0.8309126266247754 0.2838510564222687 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.0328731354880699 0.113339965404402 +Oromandibular dystonia 2 6 2.230353208591134 0.0257240033541499 1.730582524271845 4.956310679611651 1.1882502597012077 0.2382412593757527 1.131086190944388 1.1979083634266432 0.9893427275402558 0.2482274576089271 0.1081933924999157 0.066549445548378 0.1265462710440741 0.290751966651369 0.0280386150660574 +Submucous cleft of soft and hard palate 8 24 2.228367719629227 0.0258560038595276 5.138349514563107 22.941747572815533 0.8980380147163236 0.4007892874523231 2.272201189765468 2.581958475140233 0.7850752745431548 0.2945527466716488 0.0930363205394527 0.2670314735990955 0.1226746045160812 0.0660458541210367 0.0110260444811021 +Hyperconvex nail 4 9 2.223409625500868 0.0261881912384915 2.405339805825242 7.939320388349515 0.7351828941114927 0.3065172604341125 1.3467943353086171 0.7527989998960608 1.0793151443208264 0.2411455315204656 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.00262770885776 0.000160552482799 +Abnormal epiglottis morphology 1 5 2.221935847854472 0.0262876413540884 1.145631067961165 4.138349514563107 0.0455794526781296 0.4003298365054372 1.1096029814805428 0.7868982948153208 1.197451485181648 0.2907678047097171 0.1226742139485862 1.0 0.1432798584585485 0.0561137872346343 0.1818418904091173 +Elevated pulmonary artery pressure 10 26 2.214336992283387 0.0268056057064598 7.422330097087379 24.033980582524272 0.8771466934674594 0.3206437689207037 3.083196929894625 3.78086786662344 1.283632173810104 0.3146045769490745 0.0358181532121945 0.3555919235953944 0.0105112684317993 0.0057382004919105 0.0111044401007954 +Loss of speech 6 20 2.205886216343934 0.0273919675608738 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 0.0456983473100118 1.0 0.0614247268920475 0.0032788281256578 0.0038296417177728 +Abnormal thoracic spine morphology 3 31 2.2029327624527126 0.0275994880394332 6.558252427184466 27.104368932038835 0.8238927765093872 0.4398474942511601 2.7009535990178555 2.5649391710658156 0.8855000478727516 0.3360788168488923 0.0015910029305701 0.2633971592089756 0.0029226642017144 0.0629955787418294 0.1837162306077457 +Acetabular dysplasia 2 10 2.2017880588212257 0.0276802829692497 2.1237864077669903 8.589805825242719 0.3801663889605914 0.4387255567007486 1.523829244380368 1.2881811370718848 1.0266156680408756 0.3016334780122599 0.0082254277129148 0.0802348466038066 0.0113213926532688 0.0074273483269255 0.0079931710216612 +Abnormal elasticity of skin 10 63 2.198984555979305 0.0278790204742871 12.949029126213592 61.342233009708735 0.3908434863184051 0.6206140883004606 4.691432392388869 5.29075607716294 0.8206735368420446 0.3519232728015974 0.009232055698344 0.1813311010194401 0.0041049904908562 0.0146509945269355 0.0448170844289016 +Macular degeneration 3 15 2.1986177005413685 0.0279051172908577 3.5072815533980584 13.201456310679612 0.7081764422831481 0.3007939344006393 1.5711122114355351 1.3240485924903622 1.388921785741595 0.3097317018961461 0.0086290067493602 1.0 0.0135419734012732 0.0367529115341812 0.2469963169810251 +Pseudoepiphyses of the metacarpals 2 5 2.197687805553434 0.0279713611445511 1.2985436893203883 4.046116504854369 0.0282019346368502 0.4811008179492558 0.9377197169243692 0.412557105219866 1.0009566841696136 0.2897330117435 0.0556262242335954 0.0338360956076009 0.0653907127050202 0.0113265963942617 0.0034775277607499 +Variable expressivity 13 80 2.1944351725660405 0.0282041396539207 16.655339805825243 76.72572815533981 0.9137081973948464 0.4866305980303022 6.903822328870412 7.203694993346709 1.0588933116250316 0.3878161256963057 0.028110246238849 0.6476405998709945 0.0040418457473529 0.0050679728559218 0.088777811155892 +Abnormal bone structure 38 188 2.1940566774188706 0.0282313352304379 37.41747572815534 174.03398058252426 0.5052466892255619 0.6451089511590872 11.181012226303604 17.857684720378465 0.8786021869184294 0.373142151762858 0.1190355057988256 0.4574225531930811 0.1149526533167171 0.0396737527264202 0.0009679209510767 +Unilateral renal agenesis 8 23 2.189124454407147 0.02858779556796 4.62621359223301 20.31553398058253 0.5855038682969245 0.5321289482967012 2.124999653457358 2.488312770336574 0.7217913002653688 0.3066786091165442 0.0105749607533271 0.0306743412959273 0.0165254238564816 0.0112051302851985 0.0014124552017243 +Myoclonus 17 105 2.1880232455391706 0.0286679091110213 19.92718446601942 92.40291262135922 0.7794869182612147 0.4142145469430702 6.660238401732631 11.33633180094438 1.369340457412049 0.3858779422292388 0.0178371593727309 0.7204370408135331 0.0115416775225923 0.0004914899094742 0.003405429504412 +Abnormality of lower limb joint 34 178 2.187264882036516 0.0287231928209505 33.80582524271845 166.25242718446603 0.2412979108610408 0.7714482514929651 11.09824463722585 17.08912584844864 0.6310491383229854 0.3006235946777967 0.0993710217401118 0.694945036572121 0.094341938332424 0.1298774084770376 0.004407398687777 +Abnormally lax or hyperextensible skin 9 43 2.1852552258860687 0.0288701383090317 10.3373786407767 42.60679611650485 0.3474462280446399 0.5687204029624341 3.951804420390705 4.299554326326563 0.9473596696641492 0.3538650259671493 0.083180778464552 0.1267011687502946 0.033005107755267 0.0855245570517092 0.0874554037605769 +Supernumerary tooth 2 7 2.184453656699392 0.028928929120396 1.837378640776699 7.182038834951456 0.7585871881827633 0.400000437027925 1.4747917155327317 1.1734803097311852 0.8707169959243988 0.2908701317755205 0.2112978307962688 0.1330370821365251 0.2445730022705269 0.5094216597603356 0.1659016353191164 +Abnormal autonomic nervous system physiology 12 35 2.184226812410994 0.0289455856340972 8.24757281553398 32.320388349514566 0.4638475540870246 0.4509985093876737 3.0051523606495087 3.6502788621576223 1.089960321271389 0.3249871136051702 0.1270753973132237 1.0 0.1656331484196294 0.1123101919918835 0.000282388856727 +Gait ataxia 14 71 2.179645884849699 0.0292837207618663 14.351941747572816 68.35194174757281 0.6787136514518399 0.4783255809544575 5.256980668043156 6.678826209042067 1.046898326537344 0.3693668840587258 0.3898456682961305 0.5585728030790713 0.2115863552914892 0.0189254895904163 0.0066390577033407 +Erythema 4 21 2.178295235030656 0.0293840636984294 5.512135922330097 21.009708737864077 0.7860124479392929 0.4207309091489555 2.592436403423807 3.539637263054128 0.9160883902281578 0.3036972678357262 0.0178361082707862 0.2849410889163232 0.0040840095186766 0.0242455864981032 0.1130329164300312 +Abnormality of the pulmonary veins 0 8 2.175906728743089 0.029562235570689 1.2135922330097086 6.669902912621359 0.9535622979003926 0.3793496965363341 1.175399006302687 0.7806936113776552 0.7920022166500139 0.2937792263138297 0.2491592407033175 0.1583124314184509 0.2872333566147377 0.5767416823779237 0.8265804918808977 +Abnormality of pulmonary circulation 12 31 2.1739534520804704 0.0297086311452186 8.439320388349515 28.538834951456312 0.8940347945025898 0.342085103264471 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1.1033956384068455 0.3774724921329495 0.149097107200102 0.1919587855748741 0.0730872751916656 0.0182651978308217 0.0003888007355333 +Insulin resistant diabetes mellitus 1 8 2.1579102265781644 0.0309348122418635 2.1019417475728157 7.546116504854369 0.6114204624259709 0.4284525010692327 1.494097161065418 1.1618153965036069 0.891680754985607 0.2850251295246622 0.0160900301160464 0.1114073342812727 0.0219975904219434 0.1139407547181512 0.3280048671308403 +Abnormal cellular phenotype 43 199 2.157725097048457 0.0309492114881273 39.61407766990291 185.5461165048544 0.5974508379603953 0.5924097878960474 13.622479133459526 17.10902530988799 1.1142688852015548 0.3995331163327372 0.0023142419402238 0.1551233409770831 0.0002077127202739 0.0001018777766594 4.090368026610615e-06 +Horizontal nystagmus 4 25 2.156541488331004 0.0310414077996963 6.274271844660194 23.053398058252423 1.1086320165192889 0.2915732095622053 2.6115907074401723 2.1860242554539786 1.3408731048130669 0.3129960018850027 0.0095729757760163 0.2336798458054532 0.0149914480702132 0.0096445533674611 0.0465202107555725 +Exercise intolerance 6 32 2.147083503939282 0.0317866343316246 7.589805825242719 32.94660194174757 0.6935647402019111 0.4794430320014746 3.6422804337959303 3.649320073231373 0.9787082553108852 0.3464451860868903 0.4550401045993952 1.0 0.034172513126223 0.002033856678576 0.0270449321241776 +Osteoarthritis 4 9 2.146161276196669 0.0318601138815237 3.783980582524272 10.466019417475728 1.011181157871384 0.2141266987491498 1.7388858389175554 1.4384831140913243 1.3548711699904423 0.2434324139099127 0.0014713217280779 0.1287528218161406 0.0023694947377154 0.0294507732567689 0.010448798153629 +Cns demyelination 4 14 2.141376868895374 0.0322436587414141 4.330097087378641 13.868932038834952 0.932085489476866 0.3543850979390085 1.8689509518649636 1.4505793369743718 0.9962875819434424 0.3044831103069028 0.0261335387625208 1.0 0.0354914601129098 0.0383377547470353 0.0160305095638712 +Coxa valga 6 21 2.14081754739192 0.0322887543339334 5.245145631067961 19.95145631067961 0.3761170106319844 0.4485543113651226 2.6522752145550523 3.395824508532713 1.0354006500412785 0.2987185055269495 0.0151748347862839 0.0391768542263283 0.0235138787886837 0.0691718370159023 0.0353987036177446 +Sensorimotor neuropathy 5 30 2.1393579175560804 0.0324066923689161 8.980582524271844 31.118932038834952 1.3016328701661894 0.3009249972125085 3.646997920951252 3.5836645053134393 1.2437208862143418 0.3260038325488978 0.4367975808521693 1.0 0.029653655190088 0.0270875919971298 0.1251747232498637 +Supranuclear gaze palsy 5 19 2.138043616180725 0.0325132034416881 5.186893203883495 19.1626213592233 0.8242716574954257 0.3183493558985887 2.2612229396433574 2.139608194404574 1.2188387108542005 0.2935859783151378 0.0038488891828583 0.1747599807978781 0.0061250241039257 0.0023536569339089 0.010788368915323 +Urinary glycosaminoglycan excretion 1 7 2.1353800063398243 0.0327299824812743 2.9490291262135924 6.563106796116505 0.4749855796693131 0.2196485727407601 1.2846457065606351 0.9261036754709504 1.6390629541794843 0.2603486997442626 0.1154630790463651 0.0711332726649859 0.1349531130589082 0.0498779046475234 0.1641299211995837 +Abnormality of metacarpal epiphyses 3 6 2.133736330891838 0.0328643703148698 1.7839805825242718 5.046116504854369 0.2406962910537866 0.4132943637552222 1.0093907032739955 0.412557105219866 1.0697293151425844 0.2772154335257644 0.0785196824488724 0.0479914252810258 0.0921025797166938 0.0231366382468947 0.0009257875785001 +Severe short stature 8 24 2.1294177774703864 0.0332197109272909 5.997572815533981 23.890776699029125 0.6572048998571618 0.4085599295800764 2.761119431778089 3.4934352273944844 1.0243280415736038 0.3082890569118746 0.1464578257144481 0.0623838765899965 0.1897338295109766 0.1418336443700749 0.0193099294165308 +Progressive psychomotor deterioration 5 9 2.120963505895169 0.0339248736527038 3.349514563106796 8.320388349514563 0.5379615244672443 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0.5633198814967983 0.4160552944360035 2.179476502394243 2.2801276272213657 1.0919629859527038 0.3085705503430486 0.2241232989350378 0.141543756104335 0.0354914601129098 0.0063239101987386 0.0033809375709235 +Arthritis 12 43 2.0841897718414084 0.0371429087534342 10.45631067961165 41.12864077669903 0.9299077951686036 0.3844403642845474 3.7326340917241647 4.351147052994631 1.200139433310656 0.3557501916131977 0.0577729404178657 0.4135892767062017 0.0855550276988868 0.2660268009983631 0.0062115237881769 +Aplasia hypoplasia involving bones of the thorax 13 39 2.079519398531642 0.0375696367099231 9.28640776699029 35.33980582524272 0.5249215385737955 0.5461983959238311 3.2747207260659774 5.165801281013191 0.8293623778025828 0.326660670955727 0.0878161620373375 0.4717478376334574 0.127360361297291 0.0932188412403147 0.0040293935237904 +Abnormal macrophage morphology 2 6 2.0770835781292902 0.0377938459737832 2.9150485436893203 5.640776699029126 -0.1129741045260028 0.144980672561322 1.3090672390975422 1.117854819168669 1.9286041303300476 0.1913667515871486 0.1226742139485862 0.0756950383436983 0.1432798584585485 0.0062267265321947 0.0401461367370898 +Hallucinations 13 48 2.0709737670482675 0.0383612476334207 11.20388349514563 45.44660194174757 0.6705549628539956 0.4221278622600144 3.902598644570227 4.462852401771342 1.2595119979903464 0.3693437289960082 0.0088607173186997 0.3898210156701354 0.0155897140308174 0.0106685370568607 0.0010922754256425 +Congenital ichthyosiform erythroderma 0 6 2.06222882609482 0.0391859555189164 1.483009708737864 5.451456310679611 0.3763011420656366 0.4420094691835529 1.3209303392195928 0.7727600360616235 1.004780932779387 0.2961698816845319 0.0934764824591146 1.0 0.1094892401774078 0.2550529546148332 0.4511907478135378 +Muscle abnormality related to mitochondrial dysfunction 12 37 2.06069507594827 0.0393321397042032 11.12378640776699 35.58252427184466 0.9791864828781052 0.3365990386989574 4.6259837298613 4.333263242301439 1.4740065920951253 0.3430734831138388 0.1006292377029538 0.2778293030066073 0.0036673828223822 0.0010365522124053 6.98000131723506e-05 +Poikiloderma 2 5 2.0557819881869106 0.0398035349334304 1.8422330097087376 4.929611650485437 0.165321323480874 0.5981372974768383 1.4403555602285267 1.07820276776122 0.7913967552456191 0.2969939020648666 1.0 1.0 1.0 1.0 1.0 +Ventricular hypertrophy 10 40 2.0530270699115416 0.0400699521966256 10.04126213592233 36.45873786407767 1.1361758135608295 0.3518404639351837 4.440080726024568 4.153106961798495 1.0569836433105884 0.3376234863759063 0.1809277994037846 1.0 0.0632956597671369 0.0276263990590475 0.0063456243919498 +Abnormal iliac wing morphology 5 15 2.045846533326 0.0407714721290295 2.9927184466019416 11.45388349514563 0.4398572915535464 0.4575870111865495 1.8175106704590591 2.359716427347697 0.9444361293460763 0.2859810560858897 0.0456983473100118 0.0179094063189584 0.0614247268920475 0.0808776862517318 0.0153479918417224 +Low frustration tolerance 2 9 2.044848160766835 0.040869829983783 2.2402912621359223 8.861650485436893 0.6170800437496735 0.4474642212406593 1.8402268519458895 1.0394103977385205 0.9109780988264436 0.3087684537640934 0.0072960555134274 0.0756950383436983 0.0100519320580488 0.0062267265321947 0.0401461367370898 +Vegetative state 3 5 2.040161929583098 0.0413342001808947 1.5024271844660195 3.6601941747572817 0.6889646165990501 0.3006113643789318 0.899025325538738 0.9583906216441116 1.249157254962958 0.2580915876663678 0.0478709038219733 1.0 0.0563150378970086 0.0082211090226218 7.736530612306859e-05 +Abnormal femoral neck head morphology 12 49 2.0400424987242296 0.0413460930352354 11.097087378640778 44.88834951456311 0.710356821644891 0.4647128189516342 4.081724752298962 5.521112188696193 0.9531654138623804 0.3489729073692786 0.0847137862779167 0.1283414687065841 0.0338351909830103 0.0880488219416482 0.008891308509188 +Falls 4 8 2.039140079899809 0.041436049082002 2.691747572815534 7.910194174757281 0.3687428164443696 0.5014475269680574 1.806038913655999 1.6411554540725524 0.9272999954453608 0.314347637982024 1.0 1.0 1.0 1.0 0.1199524552735497 +Bilateral microphthalmos 0 6 2.0383668643325543 0.0415132575196199 1.2864077669902914 5.252427184466019 0.1710353440269415 0.5614666593852344 1.318468407100526 0.6750540661833788 0.8348381920339047 0.2883802573409094 0.1298272630870375 0.0802348466038066 0.1515272625734178 0.3411306657380243 0.5726791496550556 +Brittle hair 4 17 2.036619932276324 0.0416881437747129 3.9223300970873782 15.133495145631068 0.7155570866703008 0.488149294465297 2.2336322475397568 1.0493384034370854 0.7650144087086427 0.320703410400334 0.1982629499046588 1.0 0.0274603336438859 0.1383652025719425 0.0089325963600969 +Abnormal placenta morphology 2 8 2.036279530002009 0.0417222941299015 1.944174757281553 8.475728155339805 0.7648192021909558 0.3426805830523109 1.4036326133106245 0.983797478904342 1.0207702392187767 0.275511162241509 0.0136086826932428 0.1026081339138497 0.018640880521655 0.0983610682747182 0.0892170338783466 +Abnormality of the cerebrospinal fluid 35 157 2.034277227943264 0.0419236518361205 33.26456310679612 139.65776699029126 0.6333875809946081 0.5372237787257415 11.267291201647208 15.193792257662585 1.1555525507377646 0.3935007134599857 0.1206150666052265 0.608461948875821 0.1031571691941151 0.0441176958307019 0.0002525633030196 +Upper airway obstruction 2 5 2.0320834085692394 0.042145212733343 1.7378640776699028 4.395631067961165 0.9757524179748694 0.272585161266212 1.0188625396632285 0.5317860908423824 1.0518772900465188 0.2586596530104152 0.100864684735291 1.0 0.1180585699575878 0.2731207001200411 0.0228394808772788 +Respiratory distress 11 54 2.031907742789523 0.0421629965497372 12.805825242718448 52.09466019417476 0.6386570898760532 0.4437575130669694 5.288397728288474 5.051988998968333 1.24726945526474 0.3693239953771813 0.0235997553467621 0.4847391385004878 0.0093219096206541 0.0052370120210683 0.0136044190525648 +Primary gonadal insufficiency 2 10 2.0255133611372584 0.0428146779030491 2.8398058252427183 8.28883495145631 0.095136534376847 0.6554738921361674 2.0805544353399332 1.0845658618457932 0.6814475727061905 0.2787823434728517 0.1369226886862704 0.0847528009868792 0.1596960736798767 0.357118555081159 0.0544656750173612 +Decreased circulating progesterone 1 6 2.0239651186855863 0.0429737408674775 1.9199029126213591 5.725728155339806 0.4194255289469373 0.5362330293745715 1.455118848878142 0.5486242315644689 0.8018369578064876 0.3025026752766461 1.0 1.0 1.0 1.0 0.0312108672695238 +Abnormal circulating progesterone level 1 6 2.0239651186855863 0.0429737408674775 1.9199029126213591 5.725728155339806 0.4194255289469373 0.5362330293745715 1.455118848878142 0.5486242315644689 0.8018369578064876 0.3025026752766461 1.0 1.0 1.0 1.0 0.0312108672695238 +Chorioretinal dysplasia 5 6 2.0191470998570757 0.0434719326819617 1.7402912621359223 5.298543689320389 0.7805003547346996 0.372123736539573 1.2140072106043596 1.250513609252692 0.912363976173464 0.2760281930947573 1.0 1.0 1.0 0.4028006685093745 0.2730711037423907 +Contractures of the joints of the upper limbs 13 73 2.018021875809115 0.0435889830795714 15.5873786407767 70.82038834951456 0.961917368584866 0.453560490665382 5.296970733704175 9.19591360516456 0.9682537043334576 0.378553967263451 0.1056256871896054 0.2954003025990862 0.1632643902509063 0.0426169798265677 0.1219720992755237 +Episodic vomiting 5 12 2.017630743023084 0.0436297326080279 4.179611650485437 11.12378640776699 1.060494846441687 0.2663322982599159 1.9809215871966128 1.7630834730718608 1.1982900451883365 0.2840581402107739 1.0 1.0 0.2590666885683055 0.0063239101987386 0.0033809375709235 +Hypertrophic cardiomyopathy 27 116 2.012978114627499 0.0441169317832386 26.796116504854368 107.3495145631068 0.4274787301303976 0.4988726739093555 10.944572821213892 9.196568310864103 1.312724112644841 0.3809066370755179 0.2860063810565698 0.101739099976225 0.1782641205635585 0.0037977884378683 2.110809557950819e-06 +Meningitis 4 7 2.011364673426979 0.044286951886955 2.179611650485437 6.274271844660194 0.789971069936712 0.3622376484019577 1.3480557177345056 1.3864875660317604 0.9776190102947984 0.2839276823170232 1.0 1.0 1.0 1.0 0.1781060735503897 +Abnormality of the ribs 18 66 2.007646094287973 0.044680912672921 15.46359223300971 63.26456310679612 0.6596881680500318 0.4822792711086646 5.162987649103379 7.327989071924885 1.0464354559452582 0.3722680363619953 0.0846190597046506 0.2643557331790067 0.1330886303833328 0.060090907600599 0.0022600281486622 +Abnormality of extrapyramidal motor function 12 75 2.00579590549951 0.0448780277003808 17.723300970873787 74.23058252427184 0.6611914449106878 0.5008095396366101 5.517064505158221 6.985611887807198 1.1554912414277594 0.3847143245763222 0.0256770944986737 0.266182518567592 0.0473694372220574 0.0615871979120701 0.0758170004501617 +Abnormal lower limb bone morphology 35 180 2.0028626629493766 0.0451920316460829 36.657766990291265 165.25728155339806 0.5352167715889311 0.634339097616788 11.388414435872194 20.95665476687095 0.8935720216867307 0.3771208726436903 0.0750282069144016 0.2776032466217266 0.0781153998832659 0.0701342848310274 0.0250738761031191 +Rhizomelia 7 15 2.0023613649584853 0.0452458805449975 4.276699029126213 11.868932038834952 1.3783619481702345 0.228956695884812 2.09278482575067 1.6655579622091714 0.936017394236602 0.2616202806826952 0.3139663859894041 0.2027885470531376 0.3593428278464597 0.0998367022916053 0.0015279037069893 +Short nail 2 6 1.9971462979686645 0.0458092927766198 1.5946601941747574 4.990291262135922 0.8281151844707718 0.3406921792672602 1.016022432607237 0.7372889940840268 0.9280165491339682 0.2589439848544906 0.0709501192712976 1.0 0.0031504918831051 0.0010588751859522 0.0077568745967145 +Infantile axial hypotonia 3 10 1.99229510202338 0.0463386887973116 3.0970873786407767 9.91747572815534 0.2141703344813526 0.3664899290512883 1.6385203075306134 1.5973234399272347 1.21609252960959 0.2741067096589152 0.2177365324780222 1.0 0.2518545844225215 0.0352396407582777 0.0560616912320164 +Hyperconvex fingernails 2 6 1.9879837625507413 0.046813485813183 1.849514563106796 5.890776699029126 -0.0625068248155766 0.4618415982179777 1.17070833975769 0.362317752836059 0.9863015915491462 0.2773935338205699 0.0633191306420368 0.0385773062479974 0.0743799864466655 0.0148625463558957 0.0053637976870067 +Abnormal pupillary function 2 7 1.985808654732234 0.0470545744058836 1.7985436893203883 6.25 0.9459174425459445 0.2892194993230557 1.1928988171245156 1.7202745886032773 1.109204161812943 0.2732247962160634 0.2241232989350378 1.0 0.2590666885683055 0.1724444479617574 0.1905468417868487 +Anophthalmia 6 10 1.985235001029222 0.0471183318617907 2.861650485436894 9.395631067961164 0.4842375076047043 0.4992513937830266 1.7811813452413223 2.297377217063272 0.8357915391858239 0.2927718406240587 1.0 1.0 1.0 0.7413859127899196 0.5063201093736163 +High frequency sensorineural hearing impairment 2 5 1.9836408371548648 0.0472958933021976 1.6650485436893203 4.043689320388349 0.9386965591020852 0.2149168047575724 0.8809977505524413 0.5895810431067134 1.3383980938857114 0.231944191038228 0.0400526692576126 1.0 0.0471521402185075 0.0055694485300755 0.0010694525645264 +Abnormal speech prosody 1 7 1.982574858591922 0.0474149379855244 1.7184466019417477 7.531553398058253 0.8238611105871386 0.3292070194756458 1.3593793253030109 1.1305443806694235 1.0768574157850217 0.2870822069632543 0.1298272630870375 1.0 0.0113213926532688 0.062605312422627 0.1998160014011807 +Intrauterine growth retardation 41 211 1.9823620385605023 0.0474387351150142 39.529126213592235 192.123786407767 0.0057783619228977 0.8003097643448815 14.974464549922502 18.336967733600783 0.5380311561880176 0.2699427288761261 0.0091541579364427 0.0627826328473973 0.0031825303145349 0.0203553072544171 1.988465610553235e-05 +Bilateral talipes equinovarus 0 5 1.9810803825479788 0.0475822598873811 1.2160194174757282 5.072815533980583 0.5190331925889594 0.4052637886709829 1.0991769558198925 1.20659145801502 1.0429198424686923 0.2748805198506031 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.2550529546148332 0.4511907478135378 +Fluctuations in consciousness 2 7 1.9791213346491296 0.0478023469654889 2.871359223300971 7.104368932038835 1.0899440920546752 0.2545542015295898 1.680977263462837 1.481694234866534 1.1451509420956862 0.2733842157028129 0.1439609493286736 1.0 0.014058804472369 0.0102137155300364 0.0624183143373935 +Abnormality of bone mineral density 30 145 1.974932918066667 0.0482757611604645 27.356796116504853 134.4368932038835 0.3643048003328085 0.6271112047303443 9.127541669014532 13.17298640894851 0.8979996901173003 0.3610272080787325 0.0347924258568506 0.2855721919672975 0.0295895570824959 0.0224556045168462 0.0017584904366626 +Nephropathy 5 23 1.970288318298747 0.0488053364813896 4.953883495145631 20.679611650485437 0.6460031144846833 0.4125859609731191 2.359716427347698 2.5216098734814283 1.0719980152629416 0.3150102108345451 0.4131440684784993 0.2742474624411909 0.1290920553826253 0.2083714330221484 0.2095200016460435 +Abnormality of the nasal septum 0 7 1.9646068948756528 0.0494597533414526 2.058252427184466 5.601941747572815 -0.4765777621921677 0.4843449294042251 1.3096004187036847 0.6245745087617683 0.8267065785383844 0.2782055541721944 0.1081933924999157 0.066549445548378 0.1265462710440741 0.290751966651369 0.5034522087350044 +Memory impairment 12 39 1.9643747582580715 0.0494866478633029 9.20631067961165 37.271844660194176 0.6455055455031676 0.5315679983039603 3.950378988895289 4.419054449573657 0.8352402457141732 0.3415020574881957 0.5565333340580584 1.0 0.2462273560384733 0.0921959194184465 0.0086109576281194 +Peripheral demyelination 8 22 1.964173038307436 0.04951002837942 4.524271844660194 16.973300970873787 0.9472740181618832 0.3208012027704231 2.3341893675900383 2.269845761985369 1.1784704386991718 0.3026863353342601 0.2674108336121077 1.0 0.0513963234576887 0.063688713570506 6.630630328822088e-05 +Macrogyria 3 7 1.9617374617513728 0.0497930579783192 1.5024271844660195 5.648058252427185 0.9880312678764684 0.314713035809367 1.057793055191099 0.9137148736849272 0.850980571286911 0.2493075505833739 0.1647372735136017 0.1026081339138497 0.191600110602388 0.0983610682747182 0.0892170338783466 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..591b3a7695a2c25a1667e1fa5c138cf3c5a4192d --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 4646, + "title": "Average number of proteins per term", + "value": 25.059621179509254 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..1320860c47d5a284b2e5a320dd6e1e85916030c3 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..376d9ddd1763a7dcc295d74b2e70816f797999b8 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1789 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cognitive impairment 0.490801080974654 4.031939686779531 5.531838549255319e-05 0.2266444136320529 0.0070005515617375 176 P15289,P42858,Q9Y619,P14854,Q9BQE5,P06280,Q9H9S5,Q13426,Q14108,Q99720,Q6DKK2,P21912,Q13510,Q96RL7,P16278,Q9Y287,O95613,Q6PGP7,P49770,P50897,O43681,P12235,O95470,P21964,P04062,P13473,P03886,Q9Y2R0,P07602,Q13315,O76024,P00403,Q9Y487,P05067,O15118,P42345,Q13535,Q5XKP0,P17900,P27544,Q9NZJ7,O75503,Q03164,Q9NPL8,Q9NZ08,P54802 46 +Cerebral amyloid angiopathy 0.93465577596266 3.623054513063566 0.0002911444327331 0.7414985516087473 0.0089838221573425 2 Q9Y287 1 +Vascular tortuosity 0.9346557759626558 3.623054513063566 0.0002911444327331 0.7414985516087473 0.0089838221573425 2 P03886 1 +Flaring of rib cage 0.9320303383897256 3.6111446637176634 0.0003048485505432 0.7574487600660043 0.0089838221573425 2 P16278 1 +Hyperesthesia 0.9294049008167976 3.599216999525182 0.0003191767710333 0.773074153314661 0.0089838221573425 2 P07602 1 +Sea blue histiocytosis 0.9689107262750328 3.5478238333008156 0.0003884279287109 0.8355233613452857 0.0102170210000975 3 P16278 1 +Caudate atrophy 0.915110851808635 3.5339623291226445 0.0004093794215942 0.8507848737667434 0.010574466214462 2 P42858 1 +Micrographia 0.9151108518086276 3.533962329122501 0.0004093794215944 0.8507848737668974 0.010574466214462 2 P04062 1 +Hypertrophic nerve changes 0.8981913652275384 3.4560238409601607 0.0005482068309161 0.9217359822142276 0.0116063645112421 2 Q9NR77 1 +Hyporeflexia of upper limbs 0.8973162193698956 3.4519716666648015 0.0005565061607017 0.9246979048607692 0.011656912300236 2 Q9NR77 1 +Narrow pelvis bone 0.8763127187864665 3.3540933614256137 0.0007962549193709 0.9752980717245702 0.0143945539120565 2 P16435 1 +Abnormal pelvis bone morphology 0.8763127187864665 3.3540933614256137 0.0007962549193709 0.9752980717245702 0.0143945539120565 2 P16435 1 +Large sella turcica 0.8763127187864524 3.3540933614255364 0.0007962549193711 0.9752980717245956 0.0143945539120565 2 P16278 1 +Facial capillary hemangioma 0.8745624270711807 3.345882030989521 0.0008202128361509 0.9779020953679992 0.0146004169990705 2 P16435 1 +Elbow ankylosis 0.872812135355895 3.337662182441257 0.0008448639953921 0.9802952824685464 0.0148683262219397 2 P16435 1 +Humeroradial synostosis 0.872812135355895 3.337662182441257 0.0008448639953921 0.9802952824685464 0.0148683262219397 2 P16435 1 +Mental deterioration 0.5367313135294125 3.281951449171773 0.0010309135372852 0.991704937631642 0.0160725647457289 100 P15289,P42858,P14854,Q9BQE5,Q14108,P21912,Q13510,Q96RL7,P16278,Q9Y287,P50897,O43681,O95470,P21964,P04062,P03886,P07602,P00403,Q9Y487,P05067,O15118,Q5XKP0,P17900,P27544,Q9NZJ7,O75503,Q03164,Q9NPL8,P54802 29 +Reduced delayed hypersensitivity 0.8599766627771223 3.2771212484198533 0.0010487132462786 0.9923639770222176 0.0161600906443069 2 Q96MG7 1 +Abnormal delayed hypersensitivity skin test 0.8599766627771223 3.2771212484198533 0.0010487132462786 0.9923639770222176 0.0161600906443069 2 Q96MG7 1 +Widened cerebral subarachnoid space 0.904338254946192 3.2613965541626997 0.0011086487600702 0.9942216635863764 0.0163516893310674 3 P03886 1 +Abnormality of the radioulnar joints 0.8985122854217593 3.2350394192640355 0.0012162593785474 0.9964971566165994 0.0172278691241807 3 Q96L58 1 +Radioulnar dislocation 0.8985122854217593 3.2350394192640355 0.0012162593785474 0.9964971566165994 0.0172278691241807 3 Q96L58 1 +Saccadic oscillation 0.8973884707843145 3.229945119214233 0.0012381398228975 0.9968361375252623 0.0173577742040479 3 P04062 1 +Opsoclonus 0.8973884707843145 3.229945119214233 0.0012381398228975 0.9968361375252623 0.0173577742040479 3 P04062 1 +Ketotic hypoglycemia 0.8497666277712833 3.228630966328916 0.0012438429020864 0.9969189693900828 0.0173577742040479 2 Q13423 1 +Hip osteoarthritis 0.8491831971995369 3.2258511022228067 0.0012559867980657 0.9970881954630632 0.0173577742040479 2 P51798 1 +Amyloidosis 0.8943909599688963 3.2163412753017075 0.0012983633251577 0.9976091716726604 0.0174846261121245 3 Q9Y287 1 +Delusions 0.7847735365312097 3.1970366928807508 0.001388472630756 0.9984278739477932 0.0183438565511337 21 P15289,P42858,Q96RL7,P04062,P07602,Q9BQE5,Q9NZJ7,P49770,O43681 9 +Atlantoaxial dislocation 0.8398483080513318 3.181240007978979 0.0014664608410652 0.9989062876957616 0.0188730666692223 2 Q96L58 1 +Dilation of virchow robin spaces 0.8319719953325542 3.1434028776646876 0.0016699582277406 0.9995757176642128 0.0206050059966739 2 P43034 1 +Broad chin 0.831388564760797 3.14059292148221 0.0016860621093157 0.9996063529369966 0.0206050059966739 2 P55011 1 +Prominent crus of helix 0.8313885647607808 3.140592921482094 0.0016860621093164 0.9996063529369978 0.0206050059966739 2 Q7LGA3 1 +Calf muscle pseudohypertrophy 0.8310968494749158 3.139187569392222 0.0016941696708414 0.9996209291119852 0.0206050059966739 2 Q9H9S5 1 +Fusion of the cerebellar hemispheres 0.8310968494749158 3.139187569392222 0.0016941696708414 0.9996209291119852 0.0206050059966739 2 Q9H9S5 1 +Abnormality of the tongue muscle 0.8310968494749158 3.139187569392222 0.0016941696708414 0.9996209291119852 0.0206050059966739 2 Q9H9S5 1 +Abnormal muscle fiber alpha dystroglycan 0.8310968494749158 3.139187569392222 0.0016941696708414 0.9996209291119852 0.0206050059966739 2 Q9H9S5 1 +Decreased cervical spine mobility 0.8310968494749158 3.139187569392222 0.0016941696708414 0.9996209291119852 0.0206050059966739 2 Q9H9S5 1 +Abducens palsy 0.8739390919154437 3.1228960044570213 0.0017908101245773 0.9997582394073486 0.0216106593215234 3 P07602 1 +Osteopetrosis 0.8730668222935324 3.1188860371881315 0.001815361612961 0.9997843459092745 0.0217113956247036 3 P51798,Q15392 2 +Smooth muscle antibody positivity 0.8191365227537944 3.0813523800849194 0.0020606262499258 0.9999311477054152 0.0238744876737047 2 P49327 1 +Abnormality of fundus pigmentation 0.8644201403131244 3.0790260195086026 0.0020767854273364 0.9999361374969438 0.0238830324143694 3 P38435 1 +Hypopigmentation of the fundus 0.8644201403131244 3.0790260195086026 0.0020767854273364 0.9999361374969438 0.0238830324143694 3 P38435 1 +Bilateral tonic clonic seizure with focal onset 0.8640166711417191 3.0771611933556264 0.0020898225758787 0.9999398984675236 0.0239736189815621 3 P07602 1 +Dementia 0.5739063666934566 3.0710576303109103 0.0021330197643403 0.9999508480482484 0.0242666703497855 58 Q13510,P05067,O15118,P42858,P04062,Q9Y287,P17900,P03886,P07602,P27544,Q9NZJ7,P00403,Q14108,Q9Y487,P21912 15 +Congenital blindness 0.9075368988877524 3.064565032876308 0.002179867758272 0.9999604806510316 0.0245891783935529 4 Q13426 1 +Aortic valve calcification 0.8566507707865021 3.04303907880158 0.0023420191695799 0.9999814266494574 0.0257592335525216 3 P04062 1 +Cortical cataract 0.8109684947491264 3.0416111965900754 0.0023531563141738 0.9999823654004536 0.0257592335525216 2 Q99797 1 +Erlenmeyer flask deformity of the femurs 0.902218330414464 3.0410411853611956 0.0023576157948526 0.9999827278532006 0.0257592335525216 4 Q9NZJ7,P04062,P07602 3 +Asymmetric septal hypertrophy 0.8089264877479414 3.031644698815404 0.0024322531246219 0.999987799246832 0.0260284887273957 2 P54802 1 +Enlarged ovaries 0.853692401453453 3.029293306822046 0.0024512657283537 0.9999888331573116 0.0260284887273957 3 P21912 1 +Lop ear 0.8083430571761914 3.028794826320902 0.0024553137133558 0.9999890417157522 0.0260284887273957 2 Q9P2D1 1 +Cervical spine instability 0.8077596266044205 3.025943929621452 0.0024785826107314 0.9999901672262068 0.026112233128023 2 Q96L58 1 +Vascular skin abnormality 0.4736450742743143 3.0235205911492504 0.0024985202510863 0.9999910391982564 0.026203442633289 125 P06280,P38435,P51812,Q13426,Q14108,P21912,P16278,Q9UBM7,P48651,Q14739,O15360,Q9NWM8,P21964,Q16625,P04062,P03886,Q13315,P51648,O75844,P51798,Q13126,P00403,Q06136,Q15427,Q9Y487,P22830,Q13535,Q96L58,Q8IZA0,P10619,P28340,Q07864 32 +Increased cerebral lipofuscin 0.9302189781021828 3.011557321812601 0.0025991132489617 0.9999943913480956 0.0267653784101724 5 P50897,O75503,P07602,O14773 4 +Orchitis 0.8494309892033843 3.009451261457251 0.0026172006648845 0.999994844539178 0.0267653784101724 3 P49327,Q9NZ08 2 +Neuroinflammation 0.8494309892033843 3.009451261457251 0.0026172006648845 0.999994844539178 0.0267653784101724 3 P49327,Q9NZ08 2 +Pleuritis 0.8494309892033843 3.009451261457251 0.0026172006648845 0.999994844539178 0.0267653784101724 3 P49327,Q9NZ08 2 +Patchy changes of bone mineral density 0.8486450946610749 3.005786562614912 0.0026489486362502 0.9999955532832048 0.0269163272704244 3 Q13126 1 +Biliary tract abnormality 0.6743661268820803 2.994682956855217 0.0027473023811788 0.9999971877685524 0.0275679629869477 29 P15289,Q14739,P04062,Q5XKP0,P07602,P09601,Q9NZJ7,Q14108,O43681,O95202,Q9NSD9 11 +Disproportionate short stature 0.6692008007410231 2.991690852267815 0.0027743705914797 0.9999975209604384 0.0277795813965841 30 Q15392,P42345,P16278,Q9UHX1,O95613,O15228,O00116,Q9UBN7,Q7LGA3,Q03164,Q13426,Q14739,Q96HY6 13 +Small anterior fontanelle 0.8452088048194343 2.989742993467029 0.0027921226599789 0.9999977177429002 0.0278373430863997 3 Q13535 1 +Metatarsus valgus 0.8441785818500105 2.9849267213720423 0.0028364626515702 0.9999981437099154 0.0280985191454057 3 Q9H9S5,O43505 2 +Polar cataract 0.8855295499582101 2.9667743439657817 0.0030094174222816 0.999999170824592 0.0291894641835503 4 Q9Y287 1 +Abnormality of upper limb metaphysis 0.7946324387397894 2.961526544906369 0.0030611810478793 0.9999993485466924 0.0293425117548655 2 P26373 1 +Square face 0.8378003731087991 2.955043770063531 0.0031262469476234 0.9999995189498944 0.0293425117548655 3 Q9UHX1 1 +Abnormal biliary tract morphology 0.6919605491669859 2.94332284325714 0.0032470960597728 0.999999726114117 0.0302927874300296 26 P15289,Q14739,P04062,Q5XKP0,P07602,P09601,Q9NZJ7,Q14108,O43681,Q9NSD9 10 +Abnormal brain n acetyl aspartate level by mrs 0.8349104958581964 2.94146727728115 0.0032666135390539 0.9999997499309612 0.0302927874300296 3 P07602 1 +Reduced brain n acetyl aspartate level by mrs 0.8349104958581964 2.94146727728115 0.0032666135390539 0.9999997499309612 0.0302927874300296 3 P07602 1 +Abnormal brain choline level by mrs 0.8349104958581964 2.94146727728115 0.0032666135390539 0.9999997499309612 0.0302927874300296 3 P07602 1 +Thickened ribs 0.8767503562517065 2.927427443457329 0.0034177879701113 0.9999998764031156 0.0314436493250247 4 P16278 1 +Dilatation of the ventricular cavity 0.8313393638751121 2.924658320128274 0.0034483461881296 0.9999998928143076 0.0315996378501976 3 P27635,Q99959 2 +Progressive peripheral neuropathy 0.8724460011675327 2.908065193600072 0.0036367251372095 0.9999999554664564 0.0328984994355641 4 P15289,Q9NZJ7,P07602 3 +Undetectable electroretinogram 0.870384335087534 2.898774627540182 0.0037462406864843 0.9999999732763688 0.0334069754883036 4 P50897 1 +Cardiorespiratory arrest 0.8998343322878737 2.879749787008248 0.0039799088969343 0.9999999910135704 0.0350891480591994 5 O43772,P13473 2 +Negativism 0.8212040489558072 2.876758899512133 0.0040178245021307 0.9999999924703206 0.0352869804100177 3 Q9BQE5 1 +Fractures of the long bones 0.8205799069656429 2.873799810648394 0.00405565941501 0.9999999936885908 0.0354851104371691 3 Q13126 1 +Anteverted ears 0.7747957992998864 2.863183723482512 0.0041940729546086 0.999999996691066 0.0362861507395001 2 P27635 1 +Abnormality of femur morphology 0.5201324671238058 2.8537870350116497 0.0043201481242687 0.9999999981625538 0.037238234110116 74 Q9UHX1,P55011,Q9Y619,P06280,P51812,Q96HY6,P16278,Q7LGA3,P16435,Q14739,O15360,Q96A33,P04062,P07602,O00116,Q9P2D1,O75844,P51798,Q9Y487,Q96L58,Q96AY3,Q9NZJ7 22 +Adenomatous colonic polyposis 0.8133256063701193 2.8393263534169044 0.0045208893526456 0.999999999279931 0.0387528633438957 3 P28340 1 +Disproportionate short trunk short stature 0.8524559905109343 2.817527077293038 0.0048395033859327 0.9999999998372678 0.0407324868316006 4 Q9UHX1 1 +Recurrent pancreatitis 0.8068030286595184 2.80820308657086 0.004981879850187 0.99999999991629 0.041854997801029 3 P03886 1 +Respiratory arrest 0.8842567552758851 2.7942475349765243 0.005202064224117 0.9999999999700614 0.0432357609753987 9 P49748,O43772,P13473,P23786 4 +Intracellular accumulation of autofluorescent lipopigment storage material 0.8028320205396859 2.7891957023620253 0.0052839125151158 0.9999999999795726 0.0437885554394993 3 O14773 1 +Abnormal protein o linked glycosylation 0.8027871040558191 2.788980450628525 0.0052874256568142 0.9999999999799052 0.0437885554394993 3 Q8N511 1 +Mitral stenosis 0.8425465978300607 2.7722653729179445 0.0055667633926921 0.99999999999455 0.045614078875569 4 P04062 1 +Hypotriglyceridemia 0.7561260210034831 2.7695055503307455 0.0056141447725983 0.9999999999956324 0.0458406267372442 2 Q9Y6B6 1 +Hypolipidemia 0.7561260210034831 2.7695055503307455 0.0056141447725983 0.9999999999956324 0.0458406267372442 2 Q9Y6B6 1 +Simple ear 0.8417060228641662 2.768414295700357 0.0056329798848502 0.9999999999960004 0.0458631529167143 4 P16435 1 +Mixed demyelinating and axonal polyneuropathy 0.8409550411583964 2.764972135146313 0.0056927658465819 0.9999999999969752 0.0461009614747275 4 P03886 1 +Decerebrate rigidity 0.8727007299269882 2.7601937699133483 0.0057767087156561 0.9999999999979566 0.0462734287809285 5 P15289,Q9NZJ7,P07602,P16278 4 +Trismus 0.8363710087340546 2.743929173057562 0.00607086346461 0.9999999999994832 0.0476214809527953 4 P04062 1 +Laryngeal dystonia 0.7922381091333522 2.7382668119656715 0.0061763944367954 0.9999999999996844 0.0483089706285378 3 O75569,Q96RL7 2 +Abnormal circulating lipid concentration 0.503890781377848 2.7296851416343224 0.0063394840860202 0.9999999999998528 0.0493606043432789 80 Q15392,P42858,Q9Y4P3,P06280,Q13426,O43772,Q8N511,Q9Y6B6,Q15904,Q9UBM7,Q14739,P23786,O95470,P07602,O75844,O75845,P22830,Q16836,Q15800,P49748,P28340,Q9NZJ7,Q9NVI7,P37268 24 +Abnormal heart rate variability 0.8332382746341159 2.729516848410887 0.006342720790559 0.999999999999855 0.0493606043432789 4 P07602 1 +Concentric hypertrophic cardiomyopathy 0.789346980698215 2.7243120294496603 0.0064435597650087 0.9999999999999096 0.0499779276598175 3 P03886 1 +Anemic pallor 0.7464994165694103 2.7207716775206383 0.0065129729156687 0.9999999999999346 0.0504321202769951 2 O15360 1 +Generalized osteosclerosis 0.7870531809821122 2.7132232369076346 0.0066632201982737 0.9999999999999676 0.0514241213308631 3 Q15392 1 +Gastric ulcer 0.7866800523786801 2.7114180024203205 0.0066996109151329 0.9999999999999728 0.051619224397525 3 P04062 1 +Pancreatic islet cell hyperplasia 0.786142873691622 2.7088183690789194 0.0067523293833713 0.9999999999999788 0.0519392753561974 3 Q14739 1 +Stuttering 0.8284747233651001 2.707552627619096 0.0067781323142948 0.9999999999999812 0.0520515747639895 4 P03886 1 +Corneal opacity 0.530511693976926 2.70078461253236 0.0069176121247405 0.99999999999999 0.052773770002536 59 Q13510,Q16625,P04062,P16278,Q9Y4P3,P06280,Q9UBM7,P51648,O75844,P10619,Q9H9S5,O43505,Q06136,Q8NAT1,Q9NVI7,O95202,O75845 17 +Clumsiness 0.6977855938653557 2.6934578243585525 0.0070715091592206 0.9999999999999952 0.0537712464054647 21 Q13510,P15289,Q15067,P42858,Q9NR77,P07602,O14773,Q9NZJ7,O75503,O43681 10 +Cold induced muscle cramps 0.7814558828731198 2.686100562256601 0.007229132741588 0.9999999999999976 0.0547543361791438 3 P23786 1 +Decreased ldl cholesterol concentration 0.8235864189509485 2.684951235000125 0.0072540389316384 0.999999999999998 0.0547543361791438 4 P37268,Q15800 2 +Truncal titubation 0.7389148191365096 2.6821665043781233 0.0073147042983703 0.9999999999999984 0.054990479239852 2 Q6PJG6 1 +Recurrent acute respiratory tract infection 0.8529636689605568 2.6721069269811117 0.0075376625602672 0.9999999999999994 0.0560485954314971 5 Q03518 1 +Angiokeratoma 0.7751097387606879 2.655239068508391 0.0079252219921059 1.0 0.0574424046416917 3 P16278 1 +Short middle phalanx of finger 0.8164039696438673 2.6516284108273007 0.008010464637477 1.0 0.0578730510891326 4 O95613,Q03164,Q9UHX1 3 +Elevated serum acid phosphatase 0.8145744079322563 2.6431183876403965 0.008214630714765 1.0 0.0580832354543364 4 Q9NZJ7,P07602 2 +Biliary tract neoplasm 0.8457043175229029 2.639467474225715 0.0083036390890967 1.0 0.0583641561390972 5 P15289,Q9NZJ7,P07602 3 +Neoplasm of the gallbladder 0.8457043175229029 2.639467474225715 0.0083036390890967 1.0 0.0583641561390972 5 P15289,Q9NZJ7,P07602 3 +Abnormality of the alveolar ridges 0.8134505450972738 2.637886451384297 0.0083424510510121 1.0 0.058548380034747 4 Q15392 1 +Aplastic clavicle 0.7712426275701754 2.636375560815059 0.0083796929252202 1.0 0.0587173225911867 3 Q9Y619 1 +Depletion of mitochondrial dna in muscle tissue 0.8127442751070637 2.6345968265057658 0.0084237274077505 1.0 0.0587970651426068 4 Q9UBX3 1 +Central scotoma 0.863891818192525 2.616639409244641 0.0088800094408409 1.0 0.0608739903899784 7 P03886,Q9H061 2 +Abnormal circulating arginine concentration 0.7252042007001227 2.611909305824561 0.0090038136332672 1.0 0.0613368301175364 2 Q9NVS9 1 +Cardiac valve calcification 0.8074394493855548 2.60984592707411 0.009058300996281 1.0 0.061527582498131 4 P04062 1 +Mitral valve calcification 0.8074394493855548 2.60984592707411 0.009058300996281 1.0 0.061527582498131 4 P04062 1 +Abnormality of lysosomal metabolism 0.8365659078506448 2.5981937386784484 0.0093715602055202 1.0 0.062647868654456 5 Q13510,Q9NZJ7,P07602 3 +Abnormal circulating citrulline concentration 0.8045503925498458 2.5963348391464467 0.0094224192780232 1.0 0.0628973562725516 4 P03886 1 +Decreased light and dark adapted electroretinogram amplitude 0.760494664551983 2.5837174007274633 0.0097741845098089 1.0 0.0648726589036747 3 P50897 1 +Cherry red spot of the macula 0.8281076389689188 2.582688535482271 0.0098033781790969 1.0 0.064919985313762 10 Q13510,P16278,P17900,P07602,P10619 5 +Abnormal glomerular basement membrane morphology 0.7179113185530952 2.5742896291958477 0.0100446149850321 1.0 0.0661009649015006 2 P52429 1 +Abnormality of head blood vessel 0.6434244766607842 2.570869289662133 0.01014436068556 1.0 0.0665327974527337 25 Q13510,P16278,P17900,P03886,Q9Y4P3,P07602,P10619,Q9NZJ7,P48651 9 +Finger swelling 0.7161610268378125 2.5652350602049943 0.0103105929071258 1.0 0.067279514952959 2 Q01968 1 +Craniofacial osteosclerosis 0.755456219217295 2.558915108290271 0.0104999378445824 1.0 0.0679424947436353 3 P51798 1 +Mitochondrial inheritance 0.7962249233485554 2.557274850998416 0.0105495825973358 1.0 0.0680741121489199 4 P03886 1 +Abnormal retinal artery morphology 0.6663933853482079 2.5535590594389923 0.0106628193662718 1.0 0.0685193067437057 22 Q13510,P16278,P17900,P03886,P07602,P10619,Q9NZJ7 7 +Endocarditis 0.8252515277240858 2.5468038432045335 0.010871452351121 1.0 0.0694756088353625 5 P49327,Q9NZ08,P04062 3 +Abnormal thalamic size 0.7936368943374164 2.5450949507501948 0.0109248027204531 1.0 0.0696250115764408 4 Q9H9S5,P11166,Q9Y5P6 3 +Bulbar signs 0.7735405246787636 2.5434216948634667 0.0109772658547664 1.0 0.0698635303578697 13 P15289,P04062,P03886,P07602,Q9NZJ7,Q99720,Q15043 7 +Limb undergrowth 0.5112097211171549 2.538078518859734 0.0111462973561964 1.0 0.0705527214126548 60 Q15392,P42345,Q13535,Q9UHX1,O95613,O15228,O00116,Q9UBN7,Q9P2D1,Q03164,Q13426,Q14739,Q96HY6,O15360,Q15427,Q07864 16 +Abnormal pr interval 0.710035005834285 2.533465028038441 0.0112941009460802 1.0 0.0711008035169228 2 P10253 1 +Prominent antitragus 0.7097432905484287 2.5319490975833374 0.0113430456575651 1.0 0.0712159326014159 2 Q92643 1 +Insidious onset 0.8208676600096657 2.526806166269775 0.0115105011307123 1.0 0.072027624306081 5 P04062 1 +Hyperextensibility of the finger joints 0.7880263800540248 2.5186286892630365 0.0117812822808889 1.0 0.07337243629626 4 P51812 1 +Abnormality of hand joint mobility 0.7880263800540248 2.5186286892630365 0.0117812822808889 1.0 0.07337243629626 4 P51812 1 +Neurofibrillary tangles 0.849733086987371 2.515024016995727 0.0119024275291452 1.0 0.0739287143053595 6 O15118,Q9Y287 2 +Pericardial effusion 0.8384543733097369 2.502798848817944 0.0123215551257613 1.0 0.0759998113577087 7 P04062,Q14108,P47985 3 +Vertebral wedging 0.7036172695449057 2.5000499001170917 0.0124175814321689 1.0 0.0760106499787313 2 Q96AY3 1 +Atlantoaxial abnormality 0.7836828723563837 2.498081015397503 0.0124867653159899 1.0 0.0763335679711699 4 Q9NWM8,Q96L58 2 +Abnormal optical coherence tomography 0.7030338389731681 2.4970054356256592 0.0125247036835236 1.0 0.0763645319076783 2 P04439 1 +Photoreceptor layer loss on macular oct 0.7030338389731681 2.4970054356256592 0.0125247036835236 1.0 0.0763645319076783 2 P04439 1 +Cavernous hemangioma 0.7828013264290854 2.493904505664134 0.0126346530900725 1.0 0.0769023782911256 4 P21912 1 +Hand oligodactyly 0.7422572462545849 2.4935852370402656 0.0126460217422341 1.0 0.0769023782911256 3 Q15427 1 +Long toe 0.8084943140036727 2.4901917467284247 0.0127674193630122 1.0 0.0772362374486394 10 Q9UHX1 1 +Large placenta 0.7399891394155751 2.4823068333876965 0.0130534820043619 1.0 0.0785487552371502 3 O75844 1 +Abnormal pupillary light reflex 0.779458265856733 2.478046978504098 0.0132103750246463 1.0 0.0786164010547878 4 Q9NZJ7,P07602 2 +Slow pupillary light response 0.779458265856733 2.478046978504098 0.0132103750246463 1.0 0.0786164010547878 4 Q9NZJ7,P07602 2 +Abnormal csf protein level 0.7601338187029308 2.4751298290299877 0.0133187749735548 1.0 0.0790463844816534 13 P15289,Q16625,P55011,P03886,Q9NR77,P07602,Q9NZJ7,P00403 8 +Punctate cataract 0.6986581096849489 2.474136155051403 0.0133558785660994 1.0 0.0790463844816534 2 Q15436 1 +Abnormal myocardium morphology 0.3857184308314045 2.4698841206714426 0.0135156825976352 1.0 0.0796876413053469 186 Q13423,Q9P032,Q96CU9,Q96IX5,Q9Y4P3,P14854,P06280,Q9H9S5,Q13426,Q14108,Q9P0J0,O43772,O43676,Q9H061,P21912,Q96RL7,P16278,P12235,O15360,Q86Y39,P47985,P23786,Q9NWS8,P04062,P13473,P03886,Q99959,P00403,P10253,Q16836,Q5XKP0,P49748,Q9BT22,Q9NPL8,Q99797,Q9NVI7,Q9NZ08,P54802,Q7KZN9 39 +Psychomotor deterioration 0.8131040249543242 2.4680930793489324 0.0135834993635386 1.0 0.079985979775666 9 P50897,Q9NZJ7,Q9Y487,P07602 4 +Spontaneous hemolytic crises 0.6971995332555465 2.466499009686763 0.0136441105736619 1.0 0.0801397442796885 2 P11166 1 +Spontaneous hematomas 0.6945740956826154 2.452734420964335 0.0141774968358323 1.0 0.0828536481751913 2 Q96MW5 1 +Abnormal thyroid hormone level 0.6931155192532145 2.4450775714569324 0.0144820989715126 1.0 0.0842100523424878 2 O14654 1 +Brushfield spots 0.7320056458881175 2.4424859752456265 0.0145864963561284 1.0 0.0842896478224484 3 O75381 1 +Progressive neurologic deterioration 0.6561913417954899 2.441656450360873 0.0146200520309511 1.0 0.0843785860072039 21 P15289,P04062,Q5XKP0,P16278,Q9Y287,P07602,Q9NZJ7,Q9NPL8,P54802,P21912 10 +Abnormal aortic valve morphology 0.5350028763809359 2.416758829427047 0.0156593886084446 1.0 0.0891664416289527 43 P04062,Q9UHX1,Q96L58,Q9Y4P3,P06280,Q9P2D1,O75844,P51812,Q6PGP7,O15360,P37268 11 +Heparan sulfate excretion in urine 0.7665904691362455 2.416727323842242 0.0156607439451625 1.0 0.0891664416289527 4 P54802 1 +Increased bone mineral density 0.6016787329498556 2.4107136912458813 0.0159213413862557 1.0 0.090318134408479 27 Q15392,P04062,Q9Y4P3,P51798,Q13126,Q14108,Q14739,P54802,Q15043 9 +Renal agenesis 0.5043188661707816 2.4070945462047417 0.0160800063515185 1.0 0.0907748596709052 55 Q15392,P42766,Q9UHX1,Q86XL3,P62847,Q7LGA3,Q9UBM7,Q9P2D1,Q8TAA9,Q13426,P42695,P16435,O15360,Q15427 14 +Abnormal pulmonary interstitial morphology 0.5637271543171112 2.404467990365404 0.0161960245391026 1.0 0.0912081575862676 35 Q13510,P49327,P04062,Q9UJW0,Q96MG7,Q8IZA0,P09601,Q14108,Q9NSD9,Q13432 10 +Ventricular arrhythmia 0.5334517810748948 2.4039182109242274 0.016220401870435 1.0 0.0912348511985971 43 P42892,P13473,P49748,P03886,Q99959,P0DP25,P00403,O43772,P12235,P23786,P21912 11 +Decreased cd4 cd8 ratio 0.7628032626456047 2.398594358055924 0.0164581355247708 1.0 0.092348427111214 4 Q13432 1 +Monochromacy 0.6831971995332593 2.3928239845691612 0.0167192597081251 1.0 0.0936349770226819 2 A2RRP1 1 +Personality changes 0.6978767372507766 2.392638147573945 0.0167277294293641 1.0 0.0936349770226819 16 P42858,P04062,Q96RL7,P03886,P00403 5 +Abnormal pericardium morphology 0.7575905663314383 2.3723588155835524 0.0176749166623066 1.0 0.0963046229239109 12 P49327,P04062,P49748,Q14108,Q9NZ08,P47985 6 +Abnormal response to endocrine stimulation test 0.7180153806463535 2.3722440351118443 0.0176804088298041 1.0 0.0963046229239109 3 Q13423 1 +Ulnar deviation of the wrist 0.7570807266274443 2.371121142173107 0.0177342174324486 1.0 0.0963046229239109 4 P16278 1 +Chromosomal breakage induced by crosslinking agents 0.7568045995812123 2.3697932355334443 0.0177980353742799 1.0 0.0963046229239109 4 P13073 1 +Abnormal heart valve morphology 0.4672889738695776 2.3607201213763416 0.0182394901846769 1.0 0.0974030705724243 82 P21964,P04062,P16278,Q9UHX1,P01889,Q96L58,Q9Y4P3,O15360,P06280,Q9P2D1,O75844,P51798,P51812,Q6PGP7,Q6ZXV5,O95202,P37268 17 +Social and occupational deterioration 0.7543250311348808 2.357859585159185 0.0183806440124885 1.0 0.0977456122200659 4 Q9BQE5 1 +Upper limb asymmetry 0.6764877479579864 2.357290748354752 0.0184088270969775 1.0 0.0977456122200659 2 Q15555 1 +Abnormal circulating free fatty acid concentration 0.753704896856983 2.354872390093945 0.0185290675797227 1.0 0.0978250545174906 4 P49748,Q16836 2 +Thoracic kyphosis 0.6705509207163929 2.353104471057545 0.0186174026253316 1.0 0.09806854035974 18 P04062,Q9UHX1 2 +Albinism 0.7137599081853792 2.350761830486554 0.0187350214306669 1.0 0.0984648298267858 3 O00203 1 +Stroke like episode 0.7824220084195326 2.3493523705655543 0.0188061000592494 1.0 0.0987267128534156 5 O76024,P03886,P00403 3 +Abnormal circulating long chain fatty acid concentration 0.7521328578552395 2.347295164551644 0.0189102676677481 1.0 0.0990497221920608 4 P23786 1 +Schizophrenia 0.6247925804119121 2.342278152582794 0.0191664247702154 1.0 0.1002783890567804 23 P15289,P21964,P04062,Q9BUK6,P07602,Q9BQE5,O76024,Q9NZJ7,O43681,P16615 10 +Abnormal nasal mucosa morphology 0.8024889798720534 2.33916275431798 0.0193270118927764 1.0 0.1008228635852672 7 Q13432,Q03518 2 +Capillary hemangioma 0.7937242968728737 2.336699302865209 0.0194548248220121 1.0 0.1011041567372128 8 P16435,Q9UHX1,Q7LGA3 3 +Cataplexy 0.7493811642049961 2.334015800975749 0.0195948945606634 1.0 0.1014915051603593 4 O15118,P26358 2 +Mucosal telangiectasiae 0.783885955825148 2.330403723503463 0.0197848231652066 1.0 0.1023611229683187 9 Q13315,Q8IZA0,P10619,Q14739,P21912 5 +Abnormality of corneal stroma 0.713452505425767 2.324959407350068 0.0200741308585548 1.0 0.1033973525153499 14 Q13510,P04062,P16278,P10619,O43505 5 +Neuronal loss in central nervous system 0.7635437605899851 2.3180476335743623 0.0204467324269432 1.0 0.1046206154797119 11 O15118,P42858,P04062,P07602,Q9NZJ7 5 +Lactose intolerance 0.7070303073315602 2.31667885637324 0.0205212321829473 1.0 0.1048862978239529 3 P42345 1 +Severe short limb dwarfism 0.7430432611689854 2.3033513084644235 0.0212590849792215 1.0 0.1067703585213201 4 Q13426 1 +Gastrointestinal infarctions 0.6662777129521434 2.3029311306876505 0.0212827182817192 1.0 0.1067703585213201 2 P01889 1 +Recurrent pharyngitis 0.6662777129521434 2.3029311306876505 0.0212827182817192 1.0 0.1067703585213201 2 P01889 1 +Angina pectoris 0.7041067750625124 2.3018298281634113 0.0213447707196037 1.0 0.1068618585811195 3 O75844 1 +Recurrent upper and lower respiratory tract infections 0.6656942823803991 2.2998143882333326 0.0214587379512554 1.0 0.1072860671482235 2 Q93008 1 +Abnormality of glycolipid metabolism 0.7857781614541332 2.2995154489107708 0.0214756871390116 1.0 0.1072860671482235 8 P15289,P17900,P07602,P06280,Q9NZJ7 5 +Abnormality of the antitragus 0.7031390812208556 2.2969091177551784 0.0216239547515142 1.0 0.1079107344527767 3 Q92643 1 +Proportionate short stature 0.54929742631997 2.294321378821115 0.0217720454523597 1.0 0.1083686312819982 35 Q15392,Q16836,Q13535,P16278,Q9Y619,Q96L58,P10619,Q14739,Q96HY6,Q07864,P21912 11 +Muscle stiffness 0.6502066556901778 2.294278843200337 0.0217744870290346 1.0 0.1083686312819982 19 P49748,Q15392,P07602,P23786 4 +Abnormality of the distal phalanges of the toes 0.7407853079651638 2.2924002720257515 0.021882556348028 1.0 0.1086397840402572 4 O75844 1 +Sensory ataxia 0.7702363103321705 2.2923238135671604 0.0218869646710462 1.0 0.1086397840402572 5 P54802 1 +Type ii transferrin isoform profile 0.7020717829004988 2.291478656217891 0.0219357449426571 1.0 0.1087657107829083 3 Q9UP83,Q15904 2 +Progressive gait ataxia 0.7413180026252687 2.2901291492171363 0.0220138310633803 1.0 0.1090365235825856 12 P15289,Q9NZJ7,P07602,O14773 4 +Posterior fossa cyst 0.7695466635604477 2.2890849967902405 0.0220744143663318 1.0 0.109220158834907 5 Q9UHX1 1 +Hypoketotic hypoglycemia 0.7914669855109281 2.2883813612366226 0.0221153221148335 1.0 0.1093061558994859 7 P49748,O43772,P23786 3 +Abnormal circulating cholesterol concentration 0.5521370569215106 2.284031134518558 0.0223697012260557 1.0 0.1101271310521079 34 Q8N511,Q15392,P42858,Q15800,Q9Y6B6,Q15904,P07602,Q9UBM7,Q9NZJ7,Q14739,Q9NVI7,P37268,O75845 13 +Abnormal placental size 0.7390285001876227 2.2838701722331685 0.0223791620875284 1.0 0.1101271310521079 4 O75844 1 +Corneal erosion 0.7672598238972832 2.278336555307439 0.0227065332786902 1.0 0.1109460525527653 5 P01889,P51648 2 +Reduced visual acuity 0.4162673448368132 2.2769955622775577 0.0227864906240127 1.0 0.1112038187386167 124 P15289,Q13277,Q9P032,Q9UHX1,Q96CU9,Q9H9S5,Q13426,P10412,O43676,Q9H061,P31939,P21912,Q15043,P16278,Q92974,P49770,P50897,O43681,Q86Y39,P03886,P07602,P51798,Q9Y6M9,P49327,P17900,O00203,Q9NZJ7,Q9NPL8,O43505,Q9NZ08 30 +Hypocholesterolemia 0.7719535289576273 2.273534042462043 0.0229940170730633 1.0 0.1113945151616843 9 Q15800,Q9Y6B6,P07602,Q9NZJ7,Q9NVI7,P37268 6 +Pedal edema 0.7882557698278214 2.27353037716157 0.0229942376838248 1.0 0.1113945151616843 7 Q14108 1 +Pericarditis 0.7662129734406131 2.273411782630613 0.0230013767618963 1.0 0.1113945151616843 5 P49327,Q9NZ08 2 +Testicular dysgenesis 0.6598599766627821 2.2685846606431346 0.0232935952968185 1.0 0.1116763950615011 2 Q8IY37 1 +Ventricular preexcitation 0.7938196914771387 2.263664573845196 0.023594752946016 1.0 0.1124369729044827 6 P00403,P03886,P13473 3 +Agyria 0.7345097561682039 2.2618909840169965 0.0237041395543224 1.0 0.1128375331653507 4 P43034,Q9H9S5 2 +Adenoma sebaceum 0.6956521739130246 2.258743189539622 0.0238993642143463 1.0 0.113418228947756 3 P52701,P21912 2 +Angiofibromas 0.6956521739130246 2.258743189539622 0.0238993642143463 1.0 0.113418228947756 3 P52701,P21912 2 +Focal segmental glomerulosclerosis 0.618800343082123 2.2549728305073655 0.0241350342194772 1.0 0.1143031284237425 22 O95470,P03886,Q14108 3 +Dysostosis multiplex 0.7586869180313893 2.250685088116734 0.0244054898976255 1.0 0.1153488362811479 10 P10619,P16278 2 +Abnormal femoral neck morphology 0.525081076205439 2.243479386662928 0.0248659176607721 1.0 0.116811985290139 39 P16278,P55011,Q9Y619,Q96L58,Q96AY3,O75844,P51812,Q96HY6,Q9Y487,Q96A33 10 +Periventricular white matter hyperintensities 0.7561689956681139 2.2384003641303374 0.0251949583158657 1.0 0.1176439963170975 10 P15289,P17900,P07602,Q9NZJ7,O75503,O43681 6 +Disproportionate short limb short stature 0.6009356595209356 2.237629283940256 0.0252452402548348 1.0 0.1177485543274116 24 Q15392,P42345,O15228,O00116,Q9UBN7,Q7LGA3,Q03164,Q13426,Q14739 9 +Short femur 0.7578798010882372 2.234110030905516 0.0254758341626459 1.0 0.118597921362378 5 Q9UHX1 1 +Oromandibular dystonia 0.7865315896494871 2.230353208591134 0.0257240033541499 1.0 0.1192418240416979 6 Q99720,Q96RL7 2 +Submucous cleft of soft and hard palate 0.5995375192799534 2.228367719629227 0.0258560038595276 1.0 0.1192418240416979 24 Q15392,Q9Y619,P62266,Q7LGA3,O75844,Q9H9S5,P48651,O43505 8 +Male pseudohermaphroditism 0.6896339132130798 2.2279419168644323 0.0258843884944779 1.0 0.1192418240416979 3 P53701 1 +Abnormal sex determination 0.6522753792298772 2.2278167544402017 0.025892737127124 1.0 0.1192418240416979 2 Q8IY37 1 +Female external genitalia in individual with 46 xy karyotype 0.6522753792298772 2.2278167544402017 0.025892737127124 1.0 0.1192418240416979 2 Q8IY37 1 +Gonadoblastoma 0.6522753792298772 2.2278167544402017 0.025892737127124 1.0 0.1192418240416979 2 Q8IY37 1 +Ovarian gonadoblastoma 0.6522753792298772 2.2278167544402017 0.025892737127124 1.0 0.1192418240416979 2 Q8IY37 1 +Hypoplasia of the vagina 0.6522753792298772 2.2278167544402017 0.025892737127124 1.0 0.1192418240416979 2 Q8IY37 1 +Hyperconvex nail 0.7615003382862635 2.223409625500868 0.0261881912384915 1.0 0.1199943953336476 9 P51812,P42892,Q9Y619,O95202 4 +Lacticaciduria 0.7266230723158746 2.223396908730559 0.0261890479699351 1.0 0.1199943953336476 4 P03886 1 +Chronic axonal neuropathy 0.6886489641085548 2.2228906288291164 0.0262231758368585 1.0 0.1200323891015218 3 O15269,Q96MW5 2 +Abnormal epiglottis morphology 0.7553060682507025 2.221935847854472 0.0262876413540884 1.0 0.1200888425070173 5 Q15427 1 +Elevated pulmonary artery pressure 0.5816040459693227 2.214336992283387 0.0268056057064598 1.0 0.1217388505495722 26 O14678,P04062,P03886,P14854,Q8IZA0,P51970,O75844,P51798,P00403,Q14108 10 +Epicanthus inversus 0.6868638014737463 2.2137280510765667 0.0268474920744057 1.0 0.1218100079860244 3 Q7Z6Z7 1 +Loss of speech 0.6253110144333038 2.205886216343934 0.0273919675608738 1.0 0.1234365482908047 20 P15289,O15118,P17900,P07602,Q9NZJ7,P50897 6 +Nonketotic hypoglycemia 0.7228415877461021 2.2048798645762995 0.0274625258096159 1.0 0.1236345880925152 4 P23786 1 +Abnormal thoracic spine morphology 0.5529758443047452 2.2029327624527126 0.0275994880394332 1.0 0.124130901675902 31 P04062,Q9UHX1,P51648 3 +Contractures of the large joints 0.6846206334175707 2.202201161242793 0.0276511020775931 1.0 0.1242427662016418 3 O75431 1 +Acetabular dysplasia 0.7486854113012029 2.2017880588212257 0.0276802829692497 1.0 0.1242537146619654 10 Q9Y584,P16278 2 +Abnormal elasticity of skin 0.4711077513763257 2.1989845559793055 0.0278790204742871 1.0 0.1249009392421244 63 P04062,Q9UHX1,Q96L58,Q9Y4P3,P38435,O75844,P51812,Q13126,P28340,Q9Y487 10 +Macular degeneration 0.6727848036467787 2.1986177005413685 0.0279051172908577 1.0 0.1249009392421244 15 P04062,P50897,P51648 3 +Pseudoepiphyses of the metacarpals 0.750190371179724 2.197687805553434 0.0279713611445511 1.0 0.1250769430968089 5 O95202,P51812 2 +Variable expressivity 0.4529231603030643 2.1944351725660405 0.0282041396539207 1.0 0.1258759918240065 80 O95470,Q70HW3,Q13510,Q9NWS8,P17900,P03886,P07602,Q9NZJ7,P00374,P00403,Q6P4A7,Q9H061,Q15427 13 +Abnormal bone structure 0.3688803872372586 2.1940566774188706 0.0282313352304379 1.0 0.1258759918240065 188 Q15392,Q13277,Q9Y619,Q9Y4P3,Q86XL3,P06280,P38435,Q14108,Q96HY6,O95202,P21912,Q13510,Q15043,P16278,O15228,Q9UBN7,Q9UBM7,O43292,P48651,Q14739,P12235,O15360,Q9NWM8,P04062,P07602,O00116,Q9P2D1,O75844,P51798,Q13126,Q9NSD9,Q9Y487,Q96L58,Q96AY3,P28340,Q9NZJ7,P54802,Q07864 38 +Unilateral renal agenesis 0.6011726740996706 2.189124454407147 0.02858779556796 1.0 0.1266147742695353 23 Q9UHX1,Q86XL3,Q9UBM7,Q7LGA3,Q13426,P42695,P16435,Q15427 8 +Myoclonus 0.433023563233736 2.1880232455391706 0.0286679091110213 1.0 0.1266748394603393 105 Q13510,P05067,Q9NWS8,P42858,P04062,P03886,P07602,O14773,P27544,Q9UBX3,P13073,P00374,P50897,Q14108,O75503,P00403,Q9NZJ7 17 +Abnormality of lower limb joint 0.3671755221616273 2.1872648820365157 0.0287231928209505 1.0 0.1266748394603393 178 P42858,Q9UHX1,P55011,Q9Y619,Q9Y4P3,Q86XL3,Q9H9S5,Q96HY6,O95202,P21912,Q13510,Q15043,P49902,P16278,Q15041,Q9NR77,Q7LGA3,Q9UBM7,P48651,P16435,O15360,Q9Y584,P23786,Q96A33,P07602,O75844,P51798,Q15427,Q9Y487,Q13535,Q96L58,Q96AY3,Q9NZJ7,P37268 34 +Abnormally lax or hyperextensible skin 0.5073670042978282 2.1852552258860687 0.0288701383090317 1.0 0.1268975048096134 43 Q9NWM8,P04062,Q9UHX1,Q96L58,Q9Y4P3,Q15904,P38435,P51812,Q9Y487 9 +Supernumerary tooth 0.7691081644156265 2.184453656699392 0.028928929120396 1.0 0.1269888487781073 7 Q9UHX1,Q9UBM7 2 +Abnormal autonomic nervous system physiology 0.5350472004366646 2.184226812410994 0.0289455856340972 1.0 0.1269888487781073 35 P15289,P42892,Q6PJG6,Q96RL7,P04062,Q15067,P07602,P06280,P0DP25,O76024,Q9NZJ7,O43681 12 +Gait ataxia 0.4551940985910298 2.179645884849699 0.0292837207618663 1.0 0.1283511006222935 71 P15289,O15118,P42858,P03886,Q9NR77,P07602,O14773,Q8IV08,O43292,Q15907,Q9NZJ7,Q14108,Q9NVI7,P12235 14 +Erythema 0.6139520991555409 2.178295235030656 0.0293840636984294 1.0 0.1284274317430888 21 P03886,Q13426,Q06136,P51648 4 +Abnormality of pulmonary circulation 0.5490684092247671 2.1739534520804704 0.0297086311452186 1.0 0.1290397744016902 31 P49327,O14678,P04062,P03886,P14854,Q8IZA0,P51970,O75844,P51798,P00403,Q14108,Q9NZ08 12 +Joint subluxation 0.7738426243831305 2.1720551544075213 0.0298515030070118 1.0 0.1290397744016902 6 P16278,Q9UHX1 2 +Irregular femoral epiphysis 0.6775863273751975 2.1659565614028224 0.0303145064781493 1.0 0.1305371527697121 3 P26373 1 +Hemoptysis 0.7145367176512845 2.164076601420583 0.0304584709521786 1.0 0.1310278296702057 4 P49327,Q9NZ08 2 +Abnormalities of placenta or umbilical cord 0.6573655167689787 2.1630659729762773 0.0305361057758388 1.0 0.1310506536768208 16 O75844,Q6PGP7,P16278 3 +Abnormality of the crus of the helix 0.6769956148829975 2.162906156359084 0.0305483981773562 1.0 0.1310506536768208 3 Q7LGA3 1 +Abnormality of cartilage of external ear 0.6769956148829975 2.162906156359084 0.0305483981773562 1.0 0.1310506536768208 3 Q7LGA3 1 +Abnormal social behavior 0.4530291021373604 2.160206077970233 0.0307567198573639 1.0 0.1318226203480746 72 P15289,P05067,Q15067,Q9P032,Q9UHX1,Q96CU9,Q5XKP0,P03886,Q9Y4P3,P07602,Q15907,Q9NZJ7,Q9NPL8,Q9P0J0,O43681,O43676,Q2TAA5,Q86Y39 18 +Insulin resistant diabetes mellitus 0.7558235475943468 2.1579102265781644 0.0309348122418635 1.0 0.1324033485946958 8 Q13426 1 +Abnormal cellular phenotype 0.3676928810703929 2.157725097048457 0.0309492114881273 1.0 0.1324033485946958 199 Q9P032,Q96CU9,Q96MG7,P09601,Q13426,Q14108,Q9P0J0,O43772,O43676,P21912,Q13510,Q15904,Q9UBX3,P13073,Q6PGP7,Q14739,P12235,O15360,Q86Y39,Q9Y584,P23786,P21964,P04062,P03886,Q9Y2R0,P07602,Q13315,O75844,P51798,Q9Y6M9,P00403,Q70HW3,P42345,P49327,Q16836,Q9UJW0,P49748,O14773,P51970,Q9NZJ7,O75503,Q9NPL8,Q7KZN9 43 +Horizontal nystagmus 0.5810889161299686 2.156541488331004 0.0310414077996963 1.0 0.132547263917831 25 Q9H061,P04062,P07602,O14773 4 +Epispadias 0.7129369161122322 2.1561950282770814 0.0310684396053633 1.0 0.132547263917831 4 Q9Y619,P48651 2 +Exercise intolerance 0.5418334820910735 2.147083503939282 0.0317866343316246 1.0 0.1351150074151218 32 P13473,P03886,Q9Y2R0,Q9H2D1,P12235,P23786 6 +Osteoarthritis 0.7455052914657552 2.146161276196669 0.0318601138815237 1.0 0.1353035549301274 9 O75844,P04062,Q14108,Q96HY6 4 +Ivory epiphyses 0.6730535562073914 2.142522945289882 0.0321514242920253 1.0 0.1362915303473993 3 Q13535 1 +Cns demyelination 0.6795618236854575 2.141376868895374 0.0322436587414141 1.0 0.1365579202485049 14 Q15067,Q9NZJ7,P07602,P51648 4 +Coxa valga 0.608040996387131 2.14081754739192 0.0322887543339334 1.0 0.1366243648774632 21 P16278,Q9Y619,Q96L58,O75844,P51812,Q96A33 6 +Sensorimotor neuropathy 0.5479160658029907 2.1393579175560804 0.0324066923689161 1.0 0.1369986285222787 30 P03886,Q9Y2R0,P07602,Q9NZJ7,P00403 5 +Supranuclear gaze palsy 0.6244501422326045 2.138043616180725 0.0325132034416881 1.0 0.1373239483546211 19 O15118,P04062,P07602,Q9NZJ7,Q99720 5 +Abnormal ossification involving the femoral head and neck 0.6720422352589271 2.1372862428428294 0.0325747171082069 1.0 0.137458797170508 3 Q96L58 1 +Ulnar claw 0.7089451403817624 2.1364989909437497 0.032638763134368 1.0 0.1376040776064193 4 Q9NR77 1 +Urinary glycosaminoglycan excretion 0.7586408839606728 2.1353800063398243 0.0327299824812743 1.0 0.1378523563717026 7 P16278 1 +Abnormality of metacarpal epiphyses 0.765547171397387 2.133736330891838 0.0328643703148698 1.0 0.1380541270188838 6 O95202,P51812,P16435 3 +Nodular goiter 0.6347724620770201 2.133008775076034 0.0329240063626419 1.0 0.138072404520628 2 Q9UPY3 1 +Hypoplastic iliac wing 0.6707452647164133 2.1305659690402012 0.0331249156503055 1.0 0.138273457422569 3 O95613 1 +Severe short stature 0.5846879213970275 2.1294177774703864 0.0332197109272909 1.0 0.1385446830953264 24 Q15392,P16278,Q9Y619,Q96L58,P10619,Q96HY6,Q07864,P21912 8 +Trichorrhexis nodosa 0.6692426169532264 2.122773721329642 0.0337728179284519 1.0 0.1403942479313914 3 Q6PGP7 1 +Progressive psychomotor deterioration 0.740317330018854 2.120963505895169 0.0339248736527038 1.0 0.1407276455271981 9 P15289,P16278,P07602,Q9NZJ7,P21912 5 +Progressive spastic quadriplegia 0.7387743413946332 2.1134558435187447 0.0345617705916185 1.0 0.1418498111030564 9 P15289,P17900,P07602,Q9NZJ7,O43681 5 +Chronic fatigue 0.7462999350332673 2.112415938218487 0.0346507891344582 1.0 0.1420896437058192 8 Q9NZJ7,P07602,Q13423 3 +Pulmonary infiltrates 0.7534597092229333 2.1109905272021727 0.0347731260880459 1.0 0.1422623370375308 7 Q13510,P49327,Q9NZ08,P04062 4 +Bruising susceptibility 0.5367814990180138 2.1089456875763113 0.0349492699721751 1.0 0.1425586552157382 32 Q9NWM8,P04062,Q96L58,P38435,Q13126,Q14108,O15360 7 +Hepatomegaly 0.3622649860779647 2.10471414153472 0.0353161987517895 1.0 0.143733713529512 179 Q96CU9,Q9Y619,P09601,Q13426,Q14108,O43772,O43676,Q96HY6,Q13510,Q96RL7,P16278,Q6PGP7,P00374,Q14739,Q86Y39,Q96A33,P23786,Q9NWS8,Q16625,P04062,P03886,P07602,Q9P2D1,P51798,P10253,Q15067,O15118,P49748,P28340,Q9NZJ7,Q9BT22,Q9NPL8,Q9NVI7,P54802 34 +Telangiectasia 0.5122600394724933 2.102976770271933 0.035467800151856 1.0 0.1441674536356282 38 Q13535,P03886,Q13315,Q8IZA0,P10619,P28340,Q13426,Q14739,Q07864,P21912 10 +Small for gestational age 0.4427265269264083 2.1003662816224367 0.0356966327493519 1.0 0.1448441534964971 83 P42766,Q9UHX1,P49748,Q96MG7,Q9Y619,P22695,O15360,P62847,P51812,Q6PGP7,P16435,O95202,Q9Y584,P47985 14 +Bird like facies 0.7419306187813255 2.0914677952300877 0.0364861504064428 1.0 0.1465122340435035 8 Q13426 1 +Mania 0.6698938683002148 2.0883173144074156 0.0367692206159593 1.0 0.146533942607307 14 P12235,P03886,P51812,P00403 4 +Arthritis 0.4955144808257207 2.0841897718414084 0.0371429087534342 1.0 0.1474922684345775 43 Q13510,P49327,P21964,Q96RL7,P04062,P06280,O75844,P51798,Q14108,Q14739,Q96HY6,Q9NZ08 12 +Aplasia hypoplasia involving bones of the thorax 0.5050648450502288 2.079519398531642 0.0375696367099231 1.0 0.1481736266165561 39 Q13535,Q9UHX1,O95613,Q9Y619,Q96L58,Q9UBN7,Q8TAA9,O75844,Q03164,P16435,Q14739,Q96HY6,Q15427 13 +Abnormal macrophage morphology 0.7533465146056191 2.0770835781292902 0.0377938459737832 1.0 0.1489314744649676 6 O15118,P16278 2 +Hallucinations 0.4830781214885603 2.0709737670482675 0.0383612476334207 1.0 0.1509113941616196 48 P15289,P21964,P42858,P04062,P05067,O43681,P07602,Q9BQE5,O76024,Q9NZJ7,O75503,P50897,Q6DKK2 13 +Acantholysis 0.694570104537314 2.0652148761509608 0.0389026735777378 1.0 0.1523961394959273 4 P16615 1 +Muscle abnormality related to mitochondrial dysfunction 0.5112484151533794 2.06069507594827 0.0393321397042032 1.0 0.1533304644064179 37 Q9P032,Q96CU9,P03886,P14854,Q9Y2R0,Q9UBX3,Q9Y6M9,Q9NPL8,P00403,O43676,P12235,Q86Y39 12 +Poikiloderma 0.7205269505525451 2.0557819881869106 0.0398035349334304 1.0 0.1547508144775882 5 Q9H1A4,O75431 2 +Ventricular hypertrophy 0.497476216242384 2.0530270699115416 0.0400699521966256 1.0 0.1556563527638151 40 P10253,P03886,P14854,P06280,O75844,P00403,O43772,P12235,P23786,P21912 10 +Abnormal iliac wing morphology 0.645771810155459 2.045846533326 0.0407714721290295 1.0 0.1575908980960659 15 P16278,O95613,Q96L58,Q8TAA9,P51812 5 +Low frustration tolerance 0.7247318038781985 2.044848160766835 0.040869829983783 1.0 0.1577504465250673 9 P04062,Q9UHX1 2 +Vegetative state 0.7172897071887364 2.040161929583098 0.0413342001808947 1.0 0.1589455602352193 5 P15289,Q9NZJ7,P07602 3 +Abnormal femoral neck head morphology 0.477260268023266 2.0400424987242296 0.0413460930352354 1.0 0.1589455602352193 49 P16278,P55011,Q9Y619,Q96L58,Q96AY3,Q7LGA3,O75844,P51812,Q14739,Q96HY6,Q9Y487,Q96A33 12 +Falls 0.7310592078913062 2.039140079899809 0.041436049082002 1.0 0.1591007306074227 8 Q8WVX9,Q96RL7,Q9BQT8,P21912 4 +Brittle hair 0.6265651766095994 2.036619932276324 0.0416881437747129 1.0 0.1595227571094317 17 O75844,Q9NVI7,Q6PGP7,Q9Y487 4 +Abnormal placenta morphology 0.7304666586203635 2.036279530002009 0.0417222941299015 1.0 0.1595227571094317 8 O75844,P16278 2 +Urogenital sinus anomaly 0.6524657134519909 2.0353205400781222 0.0418186307429593 1.0 0.1595227571094317 3 O14974,Q8IY37 2 +Abnormality of the cerebrospinal fluid 0.376039027969857 2.034277227943264 0.0419236518361205 1.0 0.1595227571094317 157 P15289,Q15392,Q9P032,Q96CU9,P55011,P14854,Q9H9S5,Q9P0J0,O43676,O95202,Q9NR77,Q9UBN7,Q9UBM7,P13073,P48651,P16435,O43681,O15360,Q86Y39,P23786,Q9NWS8,Q16625,P04062,P21964,P03886,P07602,P51798,P00403,Q15427,Q96L58,Q8TAA9,Q9NZJ7,Q9NPL8,O43505,Q7KZN9 35 +Upper airway obstruction 0.7156175535784315 2.0320834085692394 0.042145212733343 1.0 0.1601711218070965 5 O75844,Q96HY6 2 +Respiratory distress 0.4652184480520436 2.031907742789523 0.0421629965497372 1.0 0.1601711218070965 54 Q13510,P04062,Q9UHX1,P10253,P49748,Q9Y619,P03886,Q96L58,P07602,Q9NZJ7,P23786 11 +Primary gonadal insufficiency 0.71307395902546 2.0255133611372584 0.0428146779030491 1.0 0.1622487712378192 10 P49770,Q13426 2 +Decreased circulating progesterone 0.7419745626692089 2.0239651186855863 0.0429737408674775 1.0 0.1624540277219695 6 P16435 1 +Abnormal circulating progesterone level 0.7419745626692089 2.0239651186855863 0.0429737408674775 1.0 0.1624540277219695 6 P16435 1 +Chorioretinal dysplasia 0.7409462616822498 2.0191470998570753 0.0434719326819617 1.0 0.163937174708112 6 Q01968,Q9H9S5,O43505,Q8NAT1,P53701 5 +Contractures of the joints of the upper limbs 0.4393386161959535 2.018021875809115 0.0435889830795714 1.0 0.1639943293756718 73 P42892,Q15392,Q13535,Q9Y619,Q9NR77,Q96L58,Q8IZA0,Q7LGA3,O75844,P16435,Q99720,P37268,P23786 13 +Episodic vomiting 0.6884502387033001 2.017630743023084 0.0436297326080279 1.0 0.1639943293756718 12 P49748,Q9Y619,P22695,P03886,P00403 5 +Abnormal sternal ossification 0.6849709164500939 2.0173061095862956 0.0436635784411765 1.0 0.1639943293756718 4 O95202 1 +Abnormal echocardiogram 0.6842683041003071 2.0137898350379646 0.0440316033974648 1.0 0.1648435369739093 4 P12235 1 +Hypertrophic cardiomyopathy 0.406584292447732 2.012978114627499 0.0441169317832386 1.0 0.1650111750066295 116 Q13423,Q9P032,Q96CU9,Q96IX5,Q9Y4P3,P14854,Q9P0J0,O43676,Q9H061,P21912,P16278,P12235,O15360,Q86Y39,P47985,P13473,P03886,P00403,P10253,Q16836,Q5XKP0,P49748,Q9NPL8,Q99797,Q9NVI7,P54802,Q7KZN9 27 +Meningitis 0.7324369632777994 2.011364673426979 0.044286951886955 1.0 0.1650111750066295 7 P49327,Q9NZ08,P01889,Q8TAA9 4 +Abnormality of the ribs 0.4474176925319382 2.007646094287973 0.044680912672921 1.0 0.1654318759256153 66 Q13535,P16278,Q9UHX1,Q9Y619,Q96L58,Q9UBN7,Q9UBM7,Q9P2D1,O75844,P51798,Q8TAA9,Q03164,P16435,Q14739,Q96HY6,O95202,Q15427,P54802 18 +Abnormality of extrapyramidal motor function 0.4375647609462167 2.00579590549951 0.0448780277003808 1.0 0.1654318759256153 75 P05067,P42858,P04062,P16278,P17900,Q9Y4P3,P07602,O14949,Q9NZJ7,Q6DKK2,Q99720,P12235 12 +Abnormal lower limb bone morphology 0.3562304858174556 2.0028626629493766 0.0451920316460829 1.0 0.1662858873491023 180 Q15392,P42858,Q9UHX1,P55011,Q9Y619,P06280,P51812,Q9H9S5,Q96HY6,O95202,Q13510,P16278,O95613,Q9UBN7,Q7LGA3,Q9UBM7,P13073,P16435,Q14739,O15360,Q96A33,P04062,P07602,O00116,Q9P2D1,O75844,P51798,Q15427,Q9Y487,Q13535,Q96L58,Q96AY3,Q9NZJ7,Q03164,O43505 35 +Rhizomelia 0.6381630356354273 2.0023613649584853 0.0452458805449975 1.0 0.1663072476361223 15 Q15392,P42345,O15228,O00116,Q9UBN7,Q03164,Q14739 7 +Short nail 0.7362572807741357 1.9971462979686645 0.0458092927766198 1.0 0.1679794587530984 6 O75844,Q9Y487 2 +Infantile axial hypotonia 0.7064380694543746 1.99229510202338 0.0463386887973116 1.0 0.1697867098992979 10 P17900,Q9NZJ7,P07602 3 +Abnormality of the temporomandibular joint 0.6798591124323913 1.9916940169019193 0.0464046405917011 1.0 0.169894373671429 4 O75844 1 +Hyperconvex fingernails 0.7343076678490068 1.9879837625507413 0.046813485813183 1.0 0.1708612309904676 6 O95202,P51812 2 +Tibial torsion 0.6082263710618523 1.9872980092213068 0.0468893821594544 1.0 0.1708612309904676 2 P26196 1 +Edema of the dorsum of feet 0.608226371061845 1.9872980092212664 0.0468893821594589 1.0 0.1708612309904676 2 Q9Y263 1 +Edema of the dorsum of hands 0.608226371061845 1.9872980092212664 0.0468893821594589 1.0 0.1708612309904676 2 Q9Y263 1 +Abnormal pupillary function 0.7270798780837626 1.985808654732234 0.0470545744058836 1.0 0.1712924646556178 7 Q9NZJ7,P07602 2 +Anophthalmia 0.7050306527843371 1.985235001029222 0.0471183318617907 1.0 0.1712924646556178 10 O75569,Q96N67,Q9P2D1,Q9H9S5,O43505,Q8NAT1 6 +High frequency sensorineural hearing impairment 0.7056203650580161 1.9836408371548648 0.0472958933021976 1.0 0.1718035342314388 5 Q13510,O75844 2 +Abnormal speech prosody 0.726403019830852 1.982574858591922 0.0474149379855244 1.0 0.1720533671696771 7 P04062 1 +Intrauterine growth retardation 0.3579931789588814 1.9823620385605023 0.0474387351150142 1.0 0.1720533671696771 211 Q15392,Q9P032,Q9UHX1,Q96CU9,Q9Y619,P14854,Q13426,O43676,O95202,P21912,P16278,O95613,Q9UBN7,Q9UBM7,Q6PGP7,Q14691,P48651,O15360,Q86Y39,Q9Y584,P47985,P21964,P04062,P03886,Q9P2D1,O75844,P51798,Q9Y6M9,Q15427,Q9NSD9,Q9Y487,O75845,Q16836,Q13535,Q96L58,Q9BT22,Q03164,Q9NPL8,Q6P4A7,P37268,Q07864 41 +Fluctuations in consciousness 0.7256804209120538 1.97912133464913 0.0478023469654889 1.0 0.1728324544760011 7 P03886,P04062 2 +Myokymia 0.6061843640606864 1.975995170154695 0.0481553242280232 1.0 0.1739591211770164 2 Q9Y6X9 1 +Abnormality of bone mineral density 0.3812028903163502 1.974932918066667 0.0482757611604645 1.0 0.1739591211770164 145 Q15392,Q13277,Q9Y4P3,P06280,Q14108,Q96HY6,O95202,Q15043,Q13510,P16278,O15228,O43292,Q14739,P12235,O15360,Q9NWM8,P04062,P07602,Q9P2D1,O75844,P51798,Q13126,Q9NSD9,Q9Y487,Q96L58,Q96AY3,P28340,Q9NZJ7,P54802,Q07864 30 +Agenesis of cerebellar vermis 0.6058926487748046 1.9743793936830931 0.0483386193369625 1.0 0.1739591211770164 2 Q10713 1 +Neonatal breathing dysregulation 0.6058926487748046 1.9743793936830931 0.0483386193369625 1.0 0.1739591211770164 2 Q10713 1 +Nephropathy 0.5680969063910302 1.970288318298747 0.0488053364813896 1.0 0.1755027811861735 23 P03886,P06280,O76024,P00403,Q14108 5 +Patellar aplasia 0.6754187640597833 1.9693905078412568 0.0489082649288152 1.0 0.1757368900690455 4 Q9H1A4,Q9Y619 2 +Memory impairment 0.4912113605354313 1.9643747582580715 0.0494866478633029 1.0 0.1771547406538287 39 P15289,P05067,P42858,P49327,P01889,P03886,P07602,Q9NZJ7,P49770,P00403,O43681,Q9NZ08 12 +Peripheral demyelination 0.5739367349034101 1.9641730383074356 0.04951002837942 1.0 0.1771547406538287 22 P15289,Q9P032,P03886,Q9NR77,P07602,Q9NZJ7,O43681,Q8TB36 8 +Abnormal circulating tyrosine concentration 0.6387510942515251 1.963218466962673 0.0496207944646414 1.0 0.1771547406538287 3 Q9NVS9,Q9UJS0 2 +Macrogyria 0.7220470054859602 1.9617374617513728 0.0497930579783192 1.0 0.1774068614779686 7 Q15392,Q9H9S5,O43505 3 +Hyperlipidemia 0.5238158824133238 1.9599610663148164 0.0500003411127309 1.0 0.1778725764240032 30 O95470,P22830,P06280,O75844,P28340,Q13426,P23786 7 +Absent nipple 0.6023920653442341 1.9549689857508843 0.0505867310393757 1.0 0.1797539209768033 2 Q6NUK1 1 +Bilateral sensorineural hearing impairment 0.5369355380116753 1.9548009335598568 0.050606570950852 1.0 0.1797539209768033 27 P15289,Q15067,P55011,P03886,P07602,Q9NZJ7,P00403 7 +Aplasia hypoplasia of the ribs 0.5365121100458675 1.9517453250265944 0.0509684484766665 1.0 0.1804873564196593 27 Q13535,Q9UHX1,Q9Y619,Q96L58,Q8TAA9,Q03164,Q14739,Q96HY6,Q15427 9 +Abnormality of the lymphatic system 0.3586979054664416 1.9512885350050528 0.0510227321399616 1.0 0.1805419752644797 170 Q15392,Q13546,Q96MG7,Q5HYI8,Q13426,Q14108,Q96HY6,O95202,Q13510,Q96RL7,P16278,Q15904,Q6PGP7,Q14691,Q14739,Q96A33,P21964,Q16625,P04062,Q13315,P07602,Q9P2D1,P51798,O75845,P10253,P49327,O15118,O00203,P10619,Q96KP1,Q9NZJ7,Q9BT22,Q9NZ08,P54802 34 +Abnormal circulating acetylcarnitine concentration 0.7197751350728514 1.950852059327305 0.0510746469273328 1.0 0.1805881351783779 7 O43772,P23786 2 +Exaggerated startle response 0.7053407106184469 1.949283740931075 0.0512615491798078 1.0 0.1809231623388906 9 P16278 1 +Absent earlobe 0.6706616125886018 1.9454386980948264 0.0517222010200426 1.0 0.1821844927514163 4 Q13535 1 +Ovoid vertebral bodies 0.7180503091480788 1.942579685741395 0.0520669633351771 1.0 0.1828443776683544 7 P54802,P16278 2 +Splenomegaly 0.4201271281628762 1.939144757159057 0.0524837140928036 1.0 0.1834757981001998 96 Q15392,Q13546,Q14108,Q96HY6,Q13510,Q96RL7,P16278,Q15904,Q6PGP7,Q14739,Q96A33,P21964,Q16625,P04062,Q13315,P07602,Q9P2D1,P51798,P10253,P49327,O15118,O00203,Q9NZJ7,Q9BT22,Q9NZ08,P54802 26 +Broad columella 0.6681260945709302 1.9326486559200695 0.0532794942123595 1.0 0.1849446256039162 4 P36543,Q8TC12,O00443 3 +Abnormal circulating copper concentration 0.6950818111833764 1.932310258852474 0.0533212229563633 1.0 0.1849446256039162 5 Q15904,Q9Y487 2 +Scotoma 0.6943473599007002 1.9314764248615983 0.0534241620114777 1.0 0.1849446256039162 10 Q9H061,P03886 2 +Ascending tubular aorta aneurysm 0.6949071467729939 1.931457247333656 0.0534265314801754 1.0 0.1849446256039162 5 O75844,Q96L58 2 +Thickened calvaria 0.7004246952440775 1.9249063961486923 0.0542410695852535 1.0 0.1870853818063013 9 P51812 1 +Abnormal intestine morphology 0.3540277860041096 1.9213573638983368 0.0546866698083741 1.0 0.1883426745216501 204 Q15392,Q13546,Q13277,Q5HYI8,P55011,Q9Y4P3,P06280,P09601,P51812,Q13426,O95202,P21912,P42892,Q9Y6B6,Q9UBM7,Q6PGP7,P08183,Q14739,O15360,Q96A33,Q14566,P21964,P42766,P03886,Q9P2D1,O76024,O75844,P00403,Q15427,Q9NSD9,O14965,P49327,P42345,Q9UJW0,P49748,P62847,Q8TAA9,Q07812,P28340,Q9BT22,Q9NZ08,Q07864 42 +Protein losing enteropathy 0.6649153531815458 1.9164288014989888 0.0553105377116698 1.0 0.1899281287571456 4 Q96MW5,Q9BT22,O00443 3 +Generalized hyperkeratosis 0.6642526275493923 1.9130775877902044 0.0557381204703315 1.0 0.1909729407855165 4 O75844 1 +Heterogeneous 0.4674053447833284 1.909803541741698 0.0561585131133886 1.0 0.1918943529353231 47 P05067,P21964,Q16836,P01889,Q9Y619,Q9NR77,P03886,Q13315,Q9BQE5,P50570,O75844,P51798,P12235,Q8TB36 14 +Micromelia 0.5521401314152354 1.9088313642951045 0.0562838494139781 1.0 0.1921342868312582 24 Q15392,Q9UHX1,O95613,Q14739,Q96HY6,Q07864 6 +Orthostatic hypotension due to autonomic dysfunction 0.6897100099395314 1.9080498427981027 0.0563847745084507 1.0 0.1923374907241277 10 P15289,P04062,P07602,Q9NZJ7,O43681 5 +Recurrent bronchitis 0.7106309359752414 1.9069169449477892 0.0565313435275833 1.0 0.1923747449463626 7 Q03519,Q03518 2 +Abnormality of exocrine pancreas physiology 0.5871067261039679 1.9067676159772575 0.0565506866444103 1.0 0.1923747449463626 19 Q5HYI8,Q15904,Q9UHX1,P09601 4 +Emg neuropathic changes 0.5584497015823614 1.9055114043074224 0.0567136264373673 1.0 0.1926827774242594 23 Q13510,P15289,Q96RL7,Q9NR77,P07602,O14773,Q9NZJ7,O43681,Q8TB36 9 +Aortic valve stenosis 0.6663318980681163 1.901235688659652 0.0572711484498824 1.0 0.1932329380523993 12 P04062,P16278 2 +Optic disc pallor 0.4595496448175126 1.899324216724226 0.0575218607248206 1.0 0.1939380006730892 50 Q13277,Q9P032,Q9Y287,Q96CU9,Q92974,P03886,Q96L58,Q9Y6M9,P51798,Q9NPL8,O43676,Q9H061,Q86Y39 13 +Abnormality of the fetal cardiovascular system 0.715143055021314 1.8974556821580884 0.0577678226071995 1.0 0.1941859031457198 6 P47985 1 +Abnormal endocrine physiology 0.6879347899501298 1.897346480568648 0.0577822242003425 1.0 0.1941859031457198 5 Q13423 1 +Goiter 0.7078690983870546 1.8936090978951543 0.0582769150182598 1.0 0.1956318982477132 7 P12235 1 +Abnormal form of the vertebral bodies 0.4212447846176702 1.8903446512517832 0.0587118806810167 1.0 0.1969497455913384 88 Q9UHX1,Q6NUQ1,Q01968,Q9Y619,Q9Y4P3,P26373,P15586,P51812,Q96HY6,O95202,Q9UM00,P16278,O15228,Q9UBN7,Q9UBM7,P16435,Q14739,Q9P2D1,P51798,Q15427,O75845,Q96L58,Q96AY3,Q96J02,Q8TAA9,P54802 26 +Skin plaque 0.6861179222421259 1.8884388028970387 0.0589670662510501 1.0 0.1976630518054684 5 Q06136 1 +Pseudoepiphyses of hand bones 0.7131765904833361 1.888119924993368 0.0590098525298534 1.0 0.197663860745277 6 O95202,P51812 2 +Retinal detachment 0.6100036847329441 1.8872026520274137 0.0591330737487909 1.0 0.1979339053579847 16 P49327,Q9Y5P6,Q9UL01,Q9H9S5,Q13426,O43505,Q8NAT1 7 +Metatarsus adductus 0.6485620671318577 1.8853375653142477 0.0593842775037762 1.0 0.1986316438319255 13 Q15392,Q96L58,O95202 3 +Abnormal vertebral morphology 0.4011048470831949 1.884960306182685 0.0594351970931992 1.0 0.1986589393489234 112 Q9UHX1,Q6NUQ1,Q01968,Q9Y619,Q9Y4P3,P26373,P15586,P51812,Q9H9S5,Q14108,Q96HY6,O95202,Q9UM00,P16278,Q9UL01,O15228,Q9UBN7,Q9UBM7,P16435,Q14739,P04062,Q9P2D1,P51798,Q15427,O75845,Q96L58,Q96AY3,Q96J02,Q8TAA9,P10619,Q8IWS0,P54802 32 +Bone pain 0.5551992275567785 1.883591033416592 0.0596203156554651 1.0 0.1988620428388748 23 P04062,P07602,P51798,Q9NZJ7,Q14108 5 +Ascites 0.5162082997165923 1.8799065209419377 0.060120819034658 1.0 0.2003739779304313 29 Q13510,O15118,P04062,Q14108,Q14739 5 +Abnormal bronchus morphology 0.5127779588956325 1.8766829829817888 0.0605615563032209 1.0 0.2012653723782291 30 Q03519,Q13277,Q03518,P16435,Q96HY6,Q13432 6 +Abnormal visual fixation 0.7102806373856676 1.874355820454498 0.0608813984898417 1.0 0.2020392695598605 6 P04062 1 +Abnormality of pelvic girdle bone morphology 0.3654714540003022 1.873440852234244 0.0610075332146458 1.0 0.2021014089838682 157 P42858,Q9UHX1,P55011,Q9Y619,Q9Y4P3,P51812,Q9H9S5,Q96HY6,O95202,P16278,O95613,O15228,Q9UBN7,Q7LGA3,P16435,Q14739,O15360,Q9Y584,Q96A33,O75844,P51798,Q15427,Q9Y487,Q13535,Q96L58,Q96AY3,Q8IZA0,Q8TAA9,Q15907,Q9NVI7 30 +Abnormal systemic arterial morphology 0.3690423345850921 1.8688445095465136 0.0616444503627118 1.0 0.2031206499185525 152 P42858,Q9UHX1,P55011,Q9Y4P3,P38435,P21912,Q13510,P16278,O95613,Q7LGA3,Q9UBM7,O15360,Q9NWM8,P21964,P42766,P04062,P03886,P07602,Q9P2D1,O75844,Q6ZXV5,Q9NSD9,P10253,P05067,O15118,O14678,P17900,Q96L58,P62847,P10619,Q9NZJ7 31 +Psychosis 0.4981824243439013 1.864945947702016 0.0621889810667537 1.0 0.203758819489519 34 O15118,Q9Y287,P03886,P51812,P00403,Q6DKK2 6 +Poor eye contact 0.4718413522384367 1.86372733098104 0.0623600052394541 1.0 0.2039614252438628 42 Q5XKP0,Q9UHX1,Q96CU9,P03886,Q15907,Q9NPL8,Q9P0J0,O43676,Q86Y39 9 +Foam cells 0.7016316227798676 1.8634897353622584 0.0623933953718327 1.0 0.2039614252438628 7 O15118,P16278 2 +Sloping forehead 0.4447233961367896 1.8632548449623132 0.0624264198658572 1.0 0.2039614252438628 57 Q16625,Q13535,O95613,Q86XL3,Q13409,Q96KP1,Q9H9S5,Q13426,P42695,Q96SN8,O15360,P23786 12 +Hyperextensible skin 0.5971349647536696 1.8603766762203195 0.0628322521791613 1.0 0.2048725631423993 17 Q96L58,P04062,Q9UHX1 3 +Abnormality of epiphysis morphology 0.4373795259304301 1.860338984762319 0.0628375812479378 1.0 0.2048725631423993 63 Q13535,P16278,O95613,Q9Y619,O15228,Q96L58,O00116,Q7LGA3,P38435,P51798,P51812,P16435,Q14739,Q96HY6,O95202 15 +Abnormal cardiac ventricular function 0.5795573786260501 1.8593427088960084 0.0629785768860784 1.0 0.2051882666288362 19 P10253,P49748,P03886,O75844,P00403,P12235,P21912 7 +Deep plantar creases 0.7070307298625145 1.8588873859561683 0.0630431024324957 1.0 0.2052545577444817 6 Q9Y487 1 +Polyneuropathy 0.596651853070468 1.857457538945984 0.0632460868343309 1.0 0.2054534679655695 17 P03886,Q9NZJ7,P07602 3 +Abnormality of the gingiva 0.4615212079367517 1.856556538856667 0.0633742720884822 1.0 0.205468854238024 47 Q15392,P04062,P16278,Q9Y4P3,Q9UBM7,O00203,Q14108,Q14739,O75845 9 +Abnormal vascular physiology 0.4448928219645645 1.85513234145121 0.0635773304170645 1.0 0.2059834568463613 56 Q9NWM8,P05067,P49327,O14678,P04062,P03886,Q9Y4P3,P14854,Q8IZA0,P06280,P51970,O75844,P51798,P00403,Q14108,Q14739,Q9NZ08 17 +Chronic sinusitis 0.6990741977142655 1.8511149679949304 0.0641530151909521 1.0 0.2071264131877441 7 Q03518 1 +Mitochondrial myopathy 0.5149268940063929 1.848912280874384 0.0644704800856224 1.0 0.2078624916570448 28 Q9P032,Q96CU9,P03886,Q9Y6M9,Q9NPL8,P00403,O43676,P12235,Q86Y39 9 +Rigidity 0.4438698332883486 1.8451391201863616 0.0650173037690149 1.0 0.2086121500765493 56 P15289,Q15392,P42858,Q6PJG6,P04062,Q9Y287,Q96CU9,P16278,P07602,Q9NZJ7,P12235 11 +Thin clavicles 0.6499533738240214 1.840499484613809 0.0656949398617445 1.0 0.209729198971741 4 O75844 1 +Blindness 0.4201271066912655 1.8386456822399024 0.0659673175028734 1.0 0.2100645353792666 81 Q9P032,Q96CU9,Q9H9S5,Q13426,O43676,P31939,P21912,P16278,P49770,P50897,Q86Y39,P03886,P07602,P51798,Q9Y6M9,P17900,Q9NZJ7,Q9NPL8,O43505,Q9NZ08 20 +Abnormal abdomen morphology 0.3498510883153855 1.835840079295865 0.0663813119136316 1.0 0.2108210182866212 230 Q15392,Q96CU9,Q5HYI8,Q9Y619,P09601,Q13426,Q14108,O43772,O43676,Q96HY6,Q13510,Q96RL7,P16278,Q6PGP7,P00374,Q14739,Q86Y39,Q96A33,P23786,Q9NWS8,Q16625,P04062,P03886,Q13315,P07602,Q9P2D1,P51798,Q9NSD9,P10253,Q15067,O15118,P49748,P10619,P28340,Q9NZJ7,Q9BT22,Q9NPL8,Q9NVI7,Q9NZ08,P54802 40 +Buphthalmos 0.6147467203224538 1.8357313570545408 0.0663973979313858 1.0 0.2108210182866212 3 Q9H9S5 1 +Lymphangioma 0.5808051341890417 1.834425805833712 0.0665908118865603 1.0 0.2108210182866212 2 O75874 1 +Hemangiomatosis 0.5808051341890417 1.834425805833712 0.0665908118865603 1.0 0.2108210182866212 2 O75874 1 +Visceral angiomatosis 0.5808051341890417 1.834425805833712 0.0665908118865603 1.0 0.2108210182866212 2 O75874 1 +Action tremor 0.4396589196198722 1.834274411683978 0.0666132705219026 1.0 0.2108210182866212 59 P15289,Q6PJG6,Q96RL7,Q9Y287,P03886,Q9NR77,P07602,O14773,Q9NZJ7,Q14108,Q99720 11 +Abnormal activity of mitochondrial respiratory chain 0.4445375983386822 1.8339042102305323 0.0666682145055346 1.0 0.2108512761012347 54 Q70HW3,Q7KZN9,Q96CU9,P03886,Q9Y2R0,P13073,Q9UBX3,Q9NPL8,Q9P0J0,O43676,Q86Y39,Q9Y584,P21912 13 +Central apnea 0.6821017054383482 1.8335246495717985 0.0667245862911871 1.0 0.2108860053801738 9 O76024,Q9NZJ7,P07602 3 +Arteriosclerosis 0.6076386499166462 1.825950968597124 0.0678576477687609 1.0 0.2123422170391516 15 O75844,O15118,P38435,P16278 4 +Abnormal enzyme coenzyme activity 0.3471990643666495 1.824343763487384 0.0681001181193154 1.0 0.2129159816839433 192 Q5HYI8,Q9Y619,Q9H9S5,O43772,Q2TAA5,Q8N511,Q13510,Q96RL7,P16278,Q9Y6B6,Q15904,Q14739,P12235,Q96A33,P23786,P42766,P04062,Q16625,P03886,Q13315,P07602,P51798,Q9NSD9,P10253,Q15067,O15118,O14678,Q16836,Q5XKP0,P49748,P22695,Q96AY3,P62847,P10619,P28340,Q9NZJ7,O43505 37 +Pulmonary embolism 0.6727869809962588 1.822843244187184 0.0683271359943922 1.0 0.2132872262951162 5 P49327,Q9NZ08 2 +Osteopenia 0.4187909860132054 1.811147593133033 0.0701180080026686 1.0 0.2176140715967926 78 Q9NWM8,P04062,Q13277,Q96L58,Q9Y4P3,Q96AY3,P07602,Q9P2D1,O75844,O43292,Q13126,Q9NZJ7,Q14108,Q9NSD9,Q9Y487,Q07864 16 +Left ventricular systolic dysfunction 0.6969537832186904 1.8107782703429904 0.0701751812635318 1.0 0.2176461229308203 6 O75844,P12235 2 +Abnormal lumbar spine morphology 0.6490769886323731 1.8094896726600296 0.0703749631384691 1.0 0.2179762986030284 12 P51812 1 +Limb ataxia 0.5439040316600511 1.807053098599801 0.0707540004944351 1.0 0.2185658818465064 23 P04062,Q9NR77,P14854,O14773,Q8IV08,Q14108 6 +Generalized hyperpigmentation 0.6192345991877384 1.805399082334772 0.0710122546682021 1.0 0.2192178971351941 14 P51648 1 +Visual loss 0.4445765486822353 1.802916087633182 0.0714013940481039 1.0 0.2198349083813724 52 P03886,P07602,O14773,P51798,Q9NZJ7,O75503,P50897,P48449,P00403 9 +Progressive visual loss 0.5359255906932033 1.797081054911153 0.0723227528596035 1.0 0.2217288255909696 24 P03886,P50897,O14773 3 +Impaired visuospatial constructive cognition 0.6748042565040755 1.7969056307384974 0.0723506025819866 1.0 0.2217288255909696 9 P03886,P00403 2 +Bilateral cryptorchidism 0.6744196710059541 1.7949722818066771 0.0726581162707729 1.0 0.2223939535510647 9 P27635,P37268,P48449,Q07864 4 +Myoclonic seizure 0.4346125817475338 1.79493930363792 0.072663370962229 1.0 0.2223939535510647 60 Q13510,Q6PJG6,P04062,Q5XKP0,P16278,Q9Y619,P03886,P07602,O43292,Q9NZJ7,O75503,Q96N66,P21912 13 +Impaired social interactions 0.4410603710678737 1.7923973450553754 0.0730693397883848 1.0 0.2231953666382878 53 Q15067,Q9P032,Q9UHX1,Q96CU9,Q5XKP0,P03886,Q15907,Q9NPL8,Q9P0J0,O43676,Q2TAA5,Q86Y39 12 +Cerebral inclusion bodies 0.6016956912782948 1.7912491943411464 0.0732533150510064 1.0 0.2236103165091824 15 O15118,P04062,Q9Y287 3 +Aplasia hypoplasia of the femur 0.5929789349421899 1.7861335999645973 0.0740776289994407 1.0 0.2255338560494112 16 Q96L58,O00116,Q9UHX1 3 +Impaired distal proprioception 0.6052017703020354 1.7845979448968572 0.0743265550122089 1.0 0.2261435328007353 3 Q96RR1 1 +Ankylosis 0.6645968752872204 1.7823403988666848 0.0746937384823933 1.0 0.2268151039145095 5 O75844,P16435 2 +Poor gross motor coordination 0.6644627441150944 1.7816758140809428 0.0748021131865113 1.0 0.2269958313942074 5 Q9H9S5,O75503 2 +Clonic seizure 0.6840230132426535 1.7779904717447717 0.0754054198111411 1.0 0.2283403342851344 7 P07602 1 +Lipoma 0.6636125151614625 1.7774622163680411 0.0754922221034255 1.0 0.2283403342851344 5 P21912,Q9BUK6,Q8TAA9 3 +Bone fracture 0.6899413605564673 1.7771713323520282 0.0755400546268298 1.0 0.2283403342851344 6 Q9H1A4,P51798,Q13126 3 +Generalized clonic seizure 0.6894507765861749 1.7748163348592276 0.0759282182804841 1.0 0.2291127232482318 6 P07602 1 +Abnormality of the larynx 0.4416270927866454 1.7747237005843173 0.0759435199746614 1.0 0.2291127232482318 52 Q13510,Q9UHX1,Q15165,O95613,P07602,Q9UBM7,Q9P2D1,Q9NZJ7,P16435,Q14739,Q96HY6,Q15427 12 +Generalized myoclonic seizure 0.4563073166402043 1.7739208355626872 0.0760762458026416 1.0 0.2293642037631881 45 Q13510,Q6PJG6,P04062,P16278,Q9Y619,P03886,P07602,Q9NZJ7,Q96N66,P21912 10 +Exercise induced muscle cramps 0.6890507201414107 1.772895532671 0.0762460190656091 1.0 0.229471654080594 6 P13473,P23786 2 +Depression 0.3971109204887256 1.771623863239174 0.0764570157464201 1.0 0.2299154013966783 107 P15289,P42858,P01889,O75165,Q15165,P55011,Q9Y4P3,P06280,P51812,Q6DKK2,Q96RL7,P50897,O43681,P12235,Q96N66,P21964,P04062,P03886,P07602,Q9P2D1,O76024,P00403,Q9BUK6,Q9NZJ7 24 +Young adult onset 0.6555672198962276 1.770515308621176 0.0766413364726388 1.0 0.2303206010684864 11 P38435,O15118,Q9NZJ7,P07602 4 +Incoordination 0.4167860266893869 1.7689565776386087 0.0769011212491237 1.0 0.2309519129433929 71 P15289,P42858,O75165,Q9Y619,Q9H9S5,Q6DKK2,P21912,Q13510,O43819,Q92974,Q9NR77,O43681,P12235,P27635,P04062,P07602,Q01105,Q15067,O14773,Q9NZJ7,O75503 21 +Oval face 0.6817652552693608 1.766978601531726 0.0772318120252548 1.0 0.2317952187786396 7 Q96L58,Q9UHX1 2 +Abnormal spermatogenesis 0.5815663413656414 1.7658953816547238 0.0774134021672694 1.0 0.2321902301285563 17 P04062,Q13423,Q13315,P16435,O15360 5 +Abnormal lower motor neuron morphology 0.6809856724868907 1.763173757015227 0.0778711884535661 1.0 0.2332621157674198 7 Q99720 1 +J shaped sella turcica 0.6343828160549398 1.7608945075261433 0.0782562597326421 1.0 0.2342645507202677 4 O75431,Q96AX1 2 +Abnormality of hepatobiliary system physiology 0.4123087435299212 1.7550937855866149 0.0792432671256415 1.0 0.236499163960126 82 P01889,Q9Y619,O43772,Q8N511,Q13510,O43819,Q6PGP7,Q96A33,P23786,Q9NWS8,Q16625,P04062,P03886,Q9NSD9,O75845,P22830,O15118,Q16836,Q5XKP0,P22695,Q9BT22 21 +Cutaneous photosensitivity 0.5164418436393531 1.7546728647773189 0.0793152800519354 1.0 0.236499163960126 26 Q13426,Q14108,Q06136 3 +Abnormality of the spleen 0.3707059476725741 1.7544814580194612 0.0793480443329577 1.0 0.236499163960126 137 Q15392,Q13546,Q5HYI8,Q14108,Q96HY6,O95202,Q13510,Q96RL7,P16278,Q15904,Q6PGP7,Q14739,Q96A33,P21964,Q16625,P04062,Q13315,P07602,Q9P2D1,P51798,O75845,P10253,P49327,O15118,O00203,P10619,Q96KP1,Q9NZJ7,Q9BT22,Q9NZ08,P54802 31 +Generalized onset seizure 0.3898821762861851 1.754329381197569 0.0793740841101655 1.0 0.236499163960126 113 Q6PJG6,P55011,Q9Y619,Q2M389,P51812,Q14108,P21912,Q13510,P16278,O43292,P00374,P43034,Q96N66,P27635,Q96N67,Q9H5V9,P04062,P03886,P07602,Q8WVX9,Q01105,P42345,P11166,Q9NZJ7,O75503,Q9NVI7 26 +Frequent falls 0.4623639841073557 1.7538228381432666 0.0794608684764865 1.0 0.236499163960126 40 Q13510,P15289,O43819,P27635,P04062,O75165,Q92974,Q9NR77,P07602,Q9H9S5,Q9NZJ7,O43681,P12235,P21912 14 +Abnormal larynx morphology 0.4841998875948186 1.7533868914125488 0.0795356195603143 1.0 0.2365700950558387 34 Q13510,Q9UHX1,O95613,P07602,Q9P2D1,Q9NZJ7,P16435,Q14739,Q96HY6,Q15427 10 +Airway obstruction 0.5793546732799179 1.7524058560005624 0.0797040452158099 1.0 0.2369193820042566 17 P06280,O75844,P09601,P16435,Q96HY6 5 +Diffuse cerebral atrophy 0.5708747125602698 1.750815199188555 0.0799777476321483 1.0 0.2375809562013819 18 P07602,P16278 2 +Hyperintensity of cerebral white matter on mri 0.5417888687421549 1.7503308062465266 0.080061248096225 1.0 0.2376770342843844 22 P15289,P21912,P10253,Q9BUK6,P17900,P07602,Q9NZJ7,O75503,O43681,Q15043 10 +Abdominal distention 0.5016259395502439 1.7495355829266597 0.0801984836183828 1.0 0.2379324105306557 28 P15289,P42345,Q13277,P04062,Q9Y6B6,P07602,Q9NZJ7,Q96HY6 8 +Inappropriate antidiuretic hormone secretion 0.565344224037345 1.7472273661393969 0.0805979065224629 1.0 0.2385444802323925 2 P50336 1 +Dilatation of the cerebral artery 0.6228513047515372 1.7441198663089528 0.081138190590283 1.0 0.2393447831634635 13 P38435,Q9NSD9,P10253 3 +Tritanomaly 0.5644690781797068 1.7422709383847104 0.0814610461636853 1.0 0.2395203586570607 2 O00429 1 +Temporal optic disc pallor 0.5644690781797068 1.7422709383847104 0.0814610461636853 1.0 0.2395203586570607 2 O00429 1 +Morning glory anomaly 0.5644690781797068 1.7422709383847104 0.0814610461636853 1.0 0.2395203586570607 2 O00429 1 +Anomalous trichromacy 0.5644690781797068 1.7422709383847104 0.0814610461636853 1.0 0.2395203586570607 2 O00429 1 +Nonimmune hydrops fetalis 0.5077626712537513 1.7421012906195696 0.0814907218105571 1.0 0.2395203586570607 27 P42766,P04062,P62847,P10619,Q14739 5 +Resting tremor 0.5774492852716183 1.7407711981800955 0.0817236924472151 1.0 0.2400052307899882 17 P12235,Q9NZJ7,P04062,P07602 4 +Abnormality of the autonomic nervous system 0.4280523308853466 1.7400369257185129 0.0818525342999285 1.0 0.240231758911856 61 P15289,P42892,Q6PJG6,Q96RL7,P21964,P04062,O15269,Q15067,P07602,P06280,Q9UBM7,P0DP25,O76024,Q9NZJ7,O43681,O15360,Q15427 17 +Focal white matter lesions 0.6815988532479331 1.7370560152865806 0.0823772840739442 1.0 0.2414667897839401 6 O00584,P12235,P42345,O00443 4 +Craniofacial hyperostosis 0.6813918189019355 1.7360586609454822 0.0825534628320685 1.0 0.2418306357615324 6 Q96L58,P51812 2 +Abnormal lymphocyte morphology 0.4537888815349691 1.735176286058799 0.0827095854502941 1.0 0.2421058883461312 44 O95470,P49327,P16278,Q96MG7,Q13315,Q9P2D1,O00203,Q6PGP7,Q13426,Q13432 10 +Retinal coloboma 0.6351650972818317 1.7349387947076913 0.082751646727003 1.0 0.2421058883461312 12 Q9UHX1 1 +Dilated cardiomyopathy 0.4500691318568959 1.7344653409974071 0.0828355502146003 1.0 0.2421988460019088 46 Q96RL7,P13473,P16278,Q16836,P49748,P03886,Q9H9S5,Q13426,P00403,P12235,P23786 11 +Alopecia totalis 0.680507353273366 1.7317969092867609 0.0833097286505024 1.0 0.2431386918483327 6 O75844 1 +Abnormality of the gastric mucosa 0.5837369808659447 1.7308657817703028 0.0834757059187318 1.0 0.2434068335802929 16 P49327,Q13546,P04062,Q9Y4P3,O76024,Q6PGP7,Q14739 7 +Cupped ear 0.6203669255484506 1.7303764231696372 0.0835630433836778 1.0 0.2434068335802929 13 P42892,Q15392 2 +Abnormality of fontanelles 0.4495450845616864 1.7296968282709275 0.0836844556854441 1.0 0.2436077575905848 46 P42345,Q13535,Q9UL01,Q96MG7,Q9Y619,O15228,O75844,P51812,Q9BT22,Q9BPU6,P48651,P16435,Q16134,Q9Y487 14 +Dysdiadochokinesis 0.5828096737045991 1.7253051983345895 0.0844724856281458 1.0 0.2451343604178379 16 Q9BUK6,P04350,O75503,Q13426,O75027,Q6DKK2 6 +Emg chronic denervation signs 0.6333391850208292 1.7251168719390908 0.0845064125446373 1.0 0.2451343604178379 12 Q13510,P15289,P07602,Q9NZJ7,O43681 5 +Abnormal aortic valve physiology 0.4542181864958462 1.7237835323979454 0.0847469285291389 1.0 0.2456233499353582 43 P49327,P04062,P16278,Q9UHX1,Q9Y4P3,O75844,Q6PGP7,Q6ZXV5,Q9NZ08 9 +Type ii lissencephaly 0.6522488629183887 1.720992667862916 0.0852521543997744 1.0 0.2467797565989731 5 Q8NAT1,Q9H9S5,O43505 3 +Segmental peripheral demyelination remyelination 0.6520837901636442 1.720170300995519 0.0854014898301747 1.0 0.2470581081886623 5 P03886,Q9NR77 2 +Head titubation 0.6714186016914259 1.7163754897585524 0.0860933396412533 1.0 0.2485951870560987 7 Q99720 1 +Positional foot deformity 0.3958918832066094 1.7130099773891434 0.0867107040556232 1.0 0.2499928742441354 103 Q15392,Q9UHX1,Q9Y619,P10412,O95202,P49902,Q9NR77,Q9UBM7,P16435,Q96A33,Q9NWM8,P21964,Q9P2D1,Q6ZXV5,Q15427,Q9Y487,Q8TB36,Q13535,Q96L58,Q96AY3,Q8TAA9,Q15907,Q9NVI7 23 +Swan neck like deformities of the fingers 0.5592182030338524 1.7124872457081457 0.086806913070244 1.0 0.2500340471942676 2 Q9NZJ4 1 +Avascular necrosis 0.5299139892865918 1.7114847055712352 0.0869916721921668 1.0 0.2502559188884255 23 P49327,P04062,Q9Y619,O75844,P51798,Q14108,Q9NZ08 7 +Abnormal epiphyseal ossification 0.5723184461773029 1.7093811819432272 0.0873803643687425 1.0 0.2510631866772899 17 Q96L58,O00116,Q9UBM7,P38435,Q14739,Q96HY6 6 +Abnormal peripheral myelination 0.4608435984573502 1.7072921634080038 0.0877677619614076 1.0 0.2516262699344317 39 P15289,Q96RL7,Q9P032,O15269,P03886,Q9NR77,P07602,Q9NZJ7,O43681,Q8TB36 10 +Abnormal retinal vascular morphology 0.4368173560625523 1.7068650435430766 0.0878471394390116 1.0 0.2516262699344317 51 Q13510,P16278,P17900,P03886,Q9Y4P3,P07602,P38435,P10619,Q9NZJ7 9 +Broad nasal tip 0.4321007331071805 1.705610734441945 0.0880805794399226 1.0 0.2519842192597787 53 P16278,Q9UHX1,Q7LGA3,P51812,Q13426,Q9Y487 6 +Hypersplenism 0.6566393781274511 1.7052183621788426 0.0881537066339381 1.0 0.2520382283207857 9 P04062,P07602,Q14108 3 +Abnormal protein glycosylation 0.5622348289334698 1.6968651141921116 0.0897221648340456 1.0 0.2555788950453562 18 Q8N511,Q9BT22,Q2TAA5,Q9Y487,P51571 5 +Hemivertebrae 0.6273420001083977 1.6927976041409276 0.0904939988952755 1.0 0.2574828134283276 12 Q9Y619,Q9UHX1,P16435 3 +Abnormal liver morphology 0.3414464059498549 1.692758815410063 0.0905013849178775 1.0 0.2574828134283276 244 Q96CU9,Q5HYI8,Q9Y619,P09601,Q13426,Q14108,O43772,O43676,Q96HY6,Q8N511,Q13510,Q96RL7,P16278,Q9Y6B6,Q6PGP7,P00374,Q14739,Q86Y39,Q96A33,P23786,Q9NWS8,Q16625,P04062,P03886,P07602,Q9P2D1,P51798,Q9NSD9,P10253,Q15067,O15118,Q16836,Q5XKP0,P49748,P10619,P28340,Q9NZJ7,Q9BT22,Q9NPL8,Q9NVI7,P54802,Q7KZN9 42 +Biparietal narrowing 0.6133094721000253 1.6912444414719052 0.090790126312851 1.0 0.257549025744239 13 Q13426,Q9UBM7 2 +Progressive spasticity 0.5770410166195986 1.690652499962009 0.0909031913426738 1.0 0.257549025744239 16 P15289,P17900,P07602,Q9NZJ7,P51812 5 +Abnormal joint morphology 0.3357986569845627 1.6892460052514056 0.0911722960174252 1.0 0.2579698461004615 288 Q15392,P42858,Q9UHX1,P55011,Q9Y619,Q9Y4P3,Q86XL3,P06280,P38435,Q9H9S5,Q14108,Q96HY6,O95202,P21912,Q13510,Q15043,P42892,Q96RL7,P49902,P16278,Q15041,O95613,Q9NR77,Q7LGA3,Q9UBM7,P48651,P16435,Q14739,O15360,Q9Y584,P23786,Q96A33,P21964,P04062,P07602,O75844,P51798,Q15427,Q9Y487,Q13535,Q96L58,Q96AY3,Q8IZA0,Q8TAA9,Q9NZJ7,Q03164,Q9NZ08,P37268,P51571 49 +Hepatic failure 0.4349188073117204 1.6887386563609084 0.091269524143676 1.0 0.2580872840878185 51 Q13510,P22830,O15118,P04062,Q16836,P01889,Q9Y619,P03886,O75381,Q96J02,Q6PGP7,O43772,O75845,P23786 14 +Ectrodactyly 0.5689049692579222 1.6884498813687057 0.0913249020749835 1.0 0.2580872840878185 17 Q9NR77,P48449,Q99720,O95202,Q8TB36 5 +Abnormality of endocrine pancreas physiology 0.6454063876262094 1.6868560253045577 0.0916310395158512 1.0 0.2586377944050091 5 Q14739 1 +Temporal pattern 0.6592527634881171 1.6864041603263449 0.091717980673633 1.0 0.2587179089974894 8 P04062 1 +Equinovarus deformity 0.6452031788003516 1.685840725674916 0.0918264812606242 1.0 0.2587179089974894 5 Q96RL7 1 +Toe walking 0.5133579274557754 1.6845598767420231 0.092073518010733 1.0 0.2589428357614199 25 P15289,O95831,O43681,P50402,P07602,Q9H9S5,Q9NZJ7,Q99720,Q13057,Q9BTV4 10 +Abnormality of upper limb joint 0.3780512430224156 1.683991289071277 0.0921833522230319 1.0 0.2590948907611655 119 Q13510,Q15392,P42892,Q13535,P16278,Q96L58,P37268,Q9Y619,Q8IZA0,Q9Y4P3,Q7LGA3,Q9NR77,O75844,Q03164,O95202,Q15427,P23786 17 +Amyotrophic lateral sclerosis 0.5830346032074707 1.681566502509707 0.0926529307182764 1.0 0.2597211239773915 15 Q15165 1 +Slurred speech 0.6453741873094194 1.6813978124718665 0.0926856701580962 1.0 0.2597211239773915 10 Q9Y487,P16278 2 +Decreased activity of mitochondrial complex iv 0.5675560665711556 1.680168044270655 0.0929246248863633 1.0 0.260233759627513 17 Q70HW3,Q9Y2R0,Q9Y584 3 +Parkinsonism 0.4895085466547155 1.677935197062851 0.0933597504657648 1.0 0.2611375079253121 29 P05067,P04062,P07602,Q9NZJ7,Q99720 5 +Tachycardia 0.4864543336544319 1.6753457448860574 0.0938664150101613 1.0 0.2617308004443424 30 P42892,P21912,P49748,P0DP25,O43772,P23786 6 +Distal peripheral sensory neuropathy 0.6427207810902267 1.673430925054766 0.0942424941460604 1.0 0.2623430963466727 5 P03886 1 +Short long bone 0.4567303309781585 1.671992198545845 0.0945258604583658 1.0 0.262816964506025 39 Q13535,P16278,Q9UHX1,Q96L58,O00116,Q96HY6,O15360,Q15427 8 +Agenesis of incisor 0.5516336056009475 1.6693327835207237 0.0950514465778487 1.0 0.2638046719239457 2 P38919 1 +Abnormality of visual evoked potentials 0.5296604914821871 1.668532142540858 0.0952101367254427 1.0 0.2638858259803354 22 P15289,Q15067,Q92974,P14854,P07602,P51798,Q9NZJ7,O75503 8 +Opisthotonus 0.4904494259414039 1.6653227521797591 0.0958483816683704 1.0 0.2644904719708839 28 Q99720,P11117,P04062,P07602 4 +Thoracolumbar scoliosis 0.6598538723285767 1.6595530131331062 0.0970044074708758 1.0 0.2663797906120331 7 P27635,P78318 2 +Decreased activity of mitochondrial complex i 0.4658805360348894 1.6588256266614037 0.0971509348091743 1.0 0.2663797906120331 36 Q70HW3,Q9P032,Q96CU9,P03886,Q9UBX3,Q9Y6M9,Q9NPL8,O43676,Q86Y39,Q9Y584 10 +Postural tremor 0.5561417216814621 1.658664936378333 0.0971833286886345 1.0 0.2663797906120331 18 P03886,O14773,Q14108 3 +Pelvic kidney 0.6473013095289617 1.6577989124568766 0.0973580609164936 1.0 0.2667013862134609 9 Q9UHX1 1 +Hypoplastic vertebral bodies 0.6594131686539465 1.6573823414462427 0.0974421992488001 1.0 0.266774577318754 7 Q14739,P16278 2 +Dry skin 0.4689972755223545 1.6569662113009476 0.0975263065542486 1.0 0.2668475973209889 35 O95613,P37268,P51648,Q9P2D1,Q96KP1,Q6PGP7,Q06136,Q2TAA5 8 +Midline defect of the nose 0.549008168028019 1.6543589198458797 0.0980546080206306 1.0 0.2679774758022815 2 P21359 1 +Biliary atresia 0.5490081680280136 1.6543589198458488 0.0980546080206368 1.0 0.2679774758022815 2 Q10713 1 +Abnormal retinal morphology 0.3396078206052872 1.6530046811092398 0.0983299108773241 1.0 0.2683957781918289 231 P42858,Q9UHX1,P01889,Q96CU9,P55011,Q9Y619,Q9Y4P3,P38435,P51812,Q9H9S5,Q13426,Q9BPU6,Q9P0J0,Q8NAT1,O95202,P21912,Q13510,O43819,Q9UM00,P16278,Q9UL01,Q9Y287,Q9Y6B6,O75381,Q15555,Q7LGA3,P50897,P27635,P21964,P04062,P03886,P07602,P51648,Q9P2D1,O76024,P00403,Q9Y487,Q15067,P49327,Q16836,Q5XKP0,Q9BUK6,P17900,O14773,P50570,P10619,Q9NZJ7,O75503,O43505,Q9NZ08,Q13432,Q7KZN9 52 +Malar rash 0.5487164527421379 1.6526940443145512 0.098393147114721 1.0 0.2683957781918289 2 P54132 1 +Hallux valgus 0.5630641839325838 1.652547316922292 0.098423027656221 1.0 0.2683957781918289 17 Q96L58,Q15427,P04062 3 +Broad based gait 0.4956417294311589 1.652470155126119 0.0984387443045364 1.0 0.2683957781918289 27 Q03164,P04062,Q13426,O14773 4 +Glomerular sclerosis 0.4714098974304843 1.650329596938151 0.0988755419837734 1.0 0.2692916146399729 34 O95470,P03886,P00403,Q14108 4 +Cardiovascular calcification 0.6458263651933582 1.6502919805122096 0.0988832317210059 1.0 0.2692916146399729 9 P04062 1 +Ectopic calcification 0.4231728555229601 1.6495939545155938 0.0990260123130768 1.0 0.2695224681936467 57 P05067,Q16625,P04062,Q96MG7,P03886,O15228,O00116,Q9UBM7,P38435,O75844,P00403,Q14739,Q9NSD9,P23786 14 +Spastic diplegia 0.5207123205419567 1.6481789272682834 0.0993159597368524 1.0 0.2700681715296633 23 Q99720,P07602,P51648 3 +Abnormal aldolase level 0.6124833434633798 1.6479750112344849 0.0993577991214897 1.0 0.2700681715296633 4 Q9H9S5,O43505 2 +Broad ribs 0.6119654461275263 1.6452917518786625 0.0999096599687741 1.0 0.2712223571652841 4 P16278 1 +Long ear 0.5472578763127334 1.644366358140014 0.1001005498470897 1.0 0.2714927931054167 2 Q7LBC6 1 +Basal ganglia calcification 0.6496076253836401 1.6381463105246774 0.1013911763506141 1.0 0.2744907808469526 8 P03886 1 +Abnormal oral mucosa morphology 0.4157965739501964 1.6377323199143938 0.1014775453970084 1.0 0.2744907808469526 63 P49327,Q15392,Q13546,P04062,P01889,P16278,Q9Y4P3,P78527,Q9UBM7,O00203,Q14108,Q14739,Q9NZ08,O75845 14 +Overlapping toe 0.5191557418651347 1.6374359872761002 0.1015394039468771 1.0 0.2744907808469526 23 Q9UM00,Q7Z6Z7,Q9UHX1,Q9UBM7,Q15907,Q15427,Q96A33 7 +Progressive sensorineural hearing impairment 0.6367488933759358 1.6367707655797314 0.101678376340847 1.0 0.2746498467904509 10 P03886,P00403 2 +Bronchitis 0.6364446891040645 1.6351938635427044 0.1020084141494672 1.0 0.2750629512428981 10 Q03519,Q03518 2 +Simple febrile seizure 0.5775590721814539 1.6351914264513083 0.1020089248797919 1.0 0.2750629512428981 3 P11166 1 +Severe combined immunodeficiency 0.6489057038601959 1.6346269960555193 0.1021272648610196 1.0 0.2752223158609613 8 Q13426,Q9P2D1 2 +Thoracic scoliosis 0.6030622690517862 1.6341939114438295 0.1022181405949174 1.0 0.2753075253356442 13 Q9UHX1 1 +Non midline cleft lip 0.6602464670709609 1.6337471370450924 0.1023119563297405 1.0 0.2754005498887454 6 Q15427 1 +Increased circulating antibody level 0.5520358618298551 1.6328542174894562 0.1024996609662747 1.0 0.275746047972966 18 P04062,Q14108 2 +Nasal regurgitation 0.5449241540256793 1.6310306911136154 0.1028838436834025 1.0 0.276619408421926 2 P53007 1 +Subependymal cysts 0.5446324387397999 1.629362757709825 0.1032362478846082 1.0 0.277406366496177 2 O00330 1 +Microretrognathia 0.5732636435824516 1.623720277406065 0.1044355213347754 1.0 0.280466723769576 15 Q9UL01,Q15427,Q16625,Q9UHX1 4 +Microcytic anemia 0.6404430856398808 1.6228545781066324 0.1046204953359162 1.0 0.2808011677242442 9 P22830,Q13546,Q9UBX3,Q9BQT8,O75027 5 +Abnormal tissue metabolite concentration 0.5723615598741889 1.6183659456042003 0.1055837564980739 1.0 0.2825937597116553 15 P15289,P17900,P07602,P06280,Q9NZJ7,O43681 6 +Synostosis of joints 0.4537187356182266 1.6150008035491314 0.1063105208581809 1.0 0.2841879631226172 38 Q9UHX1,O95613,Q96L58,Q9Y4P3,Q8TAA9,Q9H9S5,P16435,O95202,Q15427 9 +Reduced consciousness confusion 0.3644977746979898 1.614583637130058 0.1064008912717471 1.0 0.2842659809364791 129 P15289,P42858,Q13423,P01889,Q96CU9,Q9P032,Q96IX5,Q9Y619,Q9H9S5,O43772,O43676,Q16134,Q9UBM7,P49770,O43681,P12235,Q86Y39,P23786,Q9NWS8,P42766,P04062,P03886,P07602,Q9Y6M9,P00403,P05067,P49327,O14678,Q16836,P49748,P62847,Q9NZJ7,Q9NPL8,Q9NZ08 34 +Unexplained fevers 0.6556271597363985 1.6112832657613227 0.1071179964284618 1.0 0.2855898742014589 6 P07602 1 +Absent septum pellucidum 0.4601263091516422 1.6110535007100415 0.1071680620282835 1.0 0.2855898742014589 36 Q15392,P55011,Q13409,Q2M389,Q96C86,Q6P1N0,Q9H9S5,P53701,P48651,O43505,Q8NAT1,Q9NZ01,O95202,Q96N66,P51571 15 +Gingival bleeding 0.6242177169313705 1.605899322674077 0.1082960323877086 1.0 0.2871822867998256 11 Q14108 1 +Calcinosis 0.629132875915565 1.6052832030497188 0.1084314939816628 1.0 0.2873587042462123 5 O75844 1 +Abnormality of the optic nerve 0.3351711717095527 1.6021747709237433 0.1091169673764562 1.0 0.2883132427811778 262 P15289,P42858,Q13277,Q6PJG6,Q9UHX1,Q96CU9,Q9P032,P55011,P06280,P38435,P51812,Q9H9S5,Q9P0J0,O43676,O95202,P31939,Q9H061,Q15043,P49902,P16278,Q9Y287,Q92974,Q7LGA3,Q9UBM7,O43292,P49770,P50897,O43681,Q86Y39,P47985,P21964,P04062,P03886,P07602,Q9P2D1,O76024,P51798,Q9Y6M9,P00403,Q6ZXV5,Q15067,P49327,Q5XKP0,Q96L58,Q15907,Q96KP1,Q9NZJ7,Q9NPL8,O43505,Q9NVI7,Q9NZ08,P37268,Q7KZN9 53 +Orthostatic hypotension 0.5623585757701609 1.6019941284486447 0.1091569078889564 1.0 0.2883132427811778 16 P15289,P04062,P07602,Q9NZJ7,O43681 5 +Heterophoria 0.5396732788798214 1.600975318206774 0.1093823859471809 1.0 0.2887446392673879 2 Q7Z392 1 +Dysphagia 0.3600402503168133 1.60032241752497 0.1095270762041091 1.0 0.2889624054765992 137 P42858,Q9UHX1,Q14108,Q99720,P21912,Q13510,Q96RL7,Q9NR77,Q14739,P12235,P04062,P03886,P07602,Q9P2D1,P05067,O15118,Q8IZA0,Q9NZJ7,Q03164 19 +Redundant skin 0.5074416925794567 1.597942036000251 0.1100558777087867 1.0 0.2900281383068765 24 P38435,P51812,Q9Y487 3 +Limb joint contracture 0.3857387982948499 1.596333668833983 0.1104143168605722 1.0 0.2906430119740615 104 Q15392,P42892,P21912,Q13535,P49902,Q96L58,Q9Y619,Q86XL3,Q8IZA0,Q9NR77,Q7LGA3,O75844,Q99720,P37268,P23786 15 +Slender long bone 0.5685767514535522 1.5958763925847168 0.1105163931754642 1.0 0.2907469777424727 15 P37268,Q9Y619,Q96L58,Q9Y487 4 +Generalized abnormality of skin 0.336306516756362 1.5941629591939386 0.1108995404409127 1.0 0.2910135677057081 236 Q5HYI8,Q9Y4P3,P06280,P38435,P51812,Q13426,Q14108,O43772,P21912,P16278,O95613,Q15904,Q9UBM7,Q6PGP7,P00374,P48651,Q14739,O15360,Q9NWM8,P21964,Q16625,P04062,O15269,P03886,Q13315,P51648,Q9P2D1,O75844,P51798,Q13126,P00403,Q06136,Q15427,Q9Y487,P22830,O15118,Q13535,P49748,Q96L58,Q8IZA0,P10619,P28340,P37268,Q07864 44 +Abnormal urine protein level 0.4091494205408001 1.593349517718279 0.1110818038965213 1.0 0.2910135677057081 65 O95470,P04062,P03886,Q9Y4P3,P09601,P00403,Q14108 7 +Carcinoma 0.626211633810652 1.590585278579824 0.1117029396965341 1.0 0.291937740952162 5 P28340 1 +Ventricular tachycardia 0.5525373509600541 1.5875712251346903 0.1123833292390046 1.0 0.2930038987903566 17 P49748,P0DP25,O43772,P23786 4 +Bronchiectasis 0.4995055749740784 1.5853966854971842 0.1128762337847879 1.0 0.2934655747980553 25 Q03519,Q13277,Q13432,Q03518 4 +Juvenile onset 0.4413731698472796 1.5828135960624328 0.1134639568946136 1.0 0.294435014377452 41 Q13510,O15118,P16278,Q9NR77,P06280,O14773,P51798,P49770,P54802,Q14566 10 +Abnormality of the synovia 0.3942075488762843 1.5819050944424802 0.1136712377828119 1.0 0.294435014377452 89 Q96A33,Q13535,P16278,Q9UHX1,P55011,Q96L58,O15360,Q96AY3,O75844,Q9H9S5,P16435,O95202,Q15427,Q9Y487,Q9Y584 15 +Oligohydramnios 0.4659472691175453 1.5815072808362345 0.1137620955235596 1.0 0.294435014377452 33 Q9UHX1,Q96L58,Q7LGA3,P16435,O15360,P23786 6 +Lymphopenia 0.4659160631849821 1.58125617342811 0.1138194760701472 1.0 0.294435014377452 33 O95470,P49327,Q96MG7,Q13315,Q9P2D1,Q6PGP7,Q13426,Q13432 8 +Ragged red muscle fibers 0.5357214709590128 1.5797889789605315 0.1141552003762329 1.0 0.2949750060889756 19 Q9H2D1,Q70HW3,P12235,P03886 4 +Abnormal dlco 0.5358809801633759 1.57922668473992 0.1142840713124038 1.0 0.2951191317599103 2 P53621 1 +Abnormal ilium morphology 0.498614694131506 1.5789914456351244 0.1143380191923888 1.0 0.2951191317599103 25 P16278,O95613,Q96L58,Q9UBN7,Q8TAA9,P51812 6 +Phenotypic variability 0.3841797686615859 1.5767135873176503 0.1148614425593106 1.0 0.2958127838861182 104 O95470,Q70HW3,Q13510,Q9NWS8,P17900,P03886,P07602,Q9NZJ7,P00374,P00403,Q6P4A7,Q9H061,Q15427,P21912 14 +Motor neuron atrophy 0.521452464782493 1.5748937632531133 0.1152809684945037 1.0 0.2967287421747726 21 Q15165,Q99720 2 +Rectal prolapse 0.6364878928863378 1.5722074867203053 0.1159024397325771 1.0 0.2975095538074052 8 P51812 1 +Chronic pulmonary obstruction 0.6421777212919865 1.572198613737554 0.1159044968556615 1.0 0.2975095538074052 7 P09601,P06280 2 +Gastritis 0.6474168451181931 1.5712616584346668 0.1161218832674664 1.0 0.2979029650252065 6 P49327,Q13546,Q6PGP7 3 +Abnormality of the umbilical cord 0.6362312964430951 1.5709145904268598 0.1162024890552788 1.0 0.297945234078822 8 O75844 1 +Beaking of vertebral bodies 0.6240166568677773 1.570604840897969 0.1162744648307505 1.0 0.2979653412044495 10 Q96L58,Q9UM00,P16278 3 +Abnormal blood transition element cation concentration 0.6167552116807291 1.5663881563572228 0.1172577739544715 1.0 0.2998236751747247 11 Q6PGP7,Q15904,Q9Y487 3 +Abnormal midbrain morphology 0.635035446848374 1.5648875388956538 0.1176092810129239 1.0 0.3005570514774721 8 P04062 1 +Epiphyseal stippling 0.6035068260498827 1.563490106241515 0.1179373610002232 1.0 0.3008743498103997 12 Q14739,P38435,O00116,Q9UBM7 4 +Progressive external ophthalmoplegia 0.6287957686255901 1.563290927443078 0.1179841812876774 1.0 0.3008743498103997 9 P12235,P03886 2 +Abnormal diaphysis morphology 0.3976269864059703 1.5631391550072808 0.1180198677097483 1.0 0.3008743498103997 74 P16278,O95613,Q9Y619,Q9Y4P3,Q9NR77,Q96L58,Q96AY3,Q7LGA3,P51798,P51812,Q13126,P16435,Q14739,Q96HY6,Q9Y487 15 +Hypopigmented skin patches 0.4952652140552069 1.5548803915478822 0.1199745581733917 1.0 0.3050912957162441 25 P21964,P42345,O95613,P07602,Q8IZA0,Q9NZJ7,O15360,P21912 8 +Abnormal aortic valve cusp morphology 0.4952185080458646 1.554543859745806 0.1200547431690042 1.0 0.3051069739951285 25 P37268,Q96L58,Q9Y4P3,Q9UHX1 4 +Ileus 0.5942790426152923 1.553326778008568 0.1203450860290515 1.0 0.3051069739951285 4 P16930,Q01844,P50336 3 +Photophobia 0.4462817784806021 1.551419740398991 0.1208011275318634 1.0 0.3056873848110226 38 P49327,Q9Y287,P01889,P07602,P51648,O00203,Q9NZJ7,P48449,Q9NZ08,Q13432 10 +Telangiectasia of the skin 0.5114963440839955 1.544960436066268 0.122355833476585 1.0 0.3084455791276257 22 Q13315,Q8IZA0,Q13426,Q14739,Q07864 5 +Talipes equinovarus 0.3941614083951059 1.5436785818656038 0.1226662174864181 1.0 0.3088928164996741 81 Q15392,Q9Y619,P10412,O95202,Q9UM00,P49902,Q9NR77,P16435,Q96A33,Q9NWM8,P21964,Q6ZXV5,Q15427,Q9Y487,Q8TB36,O75845,Q96L58,Q96AY3,Q8TAA9,Q15907 20 +Occipital encephalocele 0.6413696304341042 1.5417098653335075 0.1231441135359756 1.0 0.3098999484787078 6 Q9H9S5,O43505,Q6ZXV5 3 +Cystinuria 0.5288798133022319 1.5389868333201906 0.1238075106671336 1.0 0.3102533411863555 2 Q9UDR5 1 +Bilateral tonic clonic seizure with generalized onset 0.6114206747141732 1.5380730994244771 0.1240307425026814 1.0 0.3104778177087596 11 P04062 1 +Abnormal metabolic brain imaging by mrs 0.5368165351460951 1.5367148794759948 0.1243631457634748 1.0 0.3109747982869236 18 P00403,P03886,Q9NZJ7,P07602 4 +Ectopia lentis 0.6109697278033517 1.5356769096672416 0.1246176409118566 1.0 0.3114375764238022 11 Q03519,Q03518 2 +Esophageal varix 0.5907953679629225 1.5351405091433077 0.1247493176333827 1.0 0.3114375764238022 4 P04062 1 +Muscle hypertrophy of the lower extremities 0.6228707775931881 1.532890869332532 0.1253027459660973 1.0 0.3123157498704336 9 P50570,Q8NAT1,Q9NR77,Q9H9S5 4 +Oligosacchariduria 0.633688072225 1.5300416203080542 0.1260064271651155 1.0 0.3135650030043529 7 Q01968,P16278,P10253 3 +Hypokinesia 0.5834643985381178 1.5243646957584691 0.1274176341093342 1.0 0.3169070278757853 13 P12235,P42858,P04062,P13473 4 +Death in adulthood 0.5699880237540508 1.5230651581235637 0.1277424046699873 1.0 0.3173877552220729 14 P05067,P51812 2 +Abnormal rib cage morphology 0.3928256407047584 1.521600554729357 0.1281091984806459 1.0 0.3178355057741781 79 Q13535,P16278,Q9UHX1,Q96L58,Q9Y619,Q9UBN7,Q9P2D1,Q8TAA9,O75844,P51798,Q9UBM7,Q03164,P16435,Q14739,Q96HY6,O95202,Q15427,P54802 18 +Decreased head circumference 0.2989319759295438 1.5215056417149633 0.1281329966239852 1.0 0.3178355057741781 476 Q15392,Q9UHX1,Q16740,P51812,Q13426,Q99720,O43676,P00374,P50897,P23786,O95470,P04062,P03886,P07602,P51648,Q06136,Q15427,Q9Y487,Q15800,P22695,Q15907,Q86XL3,O43772,O95202,Q7LGA3,P48449,Q86Y39,P42766,Q13535,P49748,P62847,Q9NZJ7,Q03164,O43505,Q7KZN9,P42858,Q96CU9,Q9Y619,Q9Y4P3,P21912,P16435,O15360,Q96A33,Q16625,Q9P2D1,Q9NSD9,Q5XKP0,Q96KP1,Q9BT22,Q9NPL8,Q99797,Q07864,P51571,Q6PJG6,Q9P032,P55011,Q9H9S5,Q2TAA5,Q15043,Q92974,O95613,O15228,Q9UBM7,Q14691,P49770,P48651,P42695,Q96N66,P21964,Q13409,P62266,Q9Y6M9,Q96SN8,Q6ZXV5,Q01105,O75845,P78527,P51970 78 +Macrovesicular hepatic steatosis 0.6369468249228749 1.520058132398478 0.1284963659098754 1.0 0.3185667641500967 6 Q5JPH6,Q5XKP0,P23786 3 +Abnormality of the gallbladder 0.439030401962003 1.5188678010938446 0.1287957752972879 1.0 0.3190183546401231 39 P15289,P21964,P04062,O75845,Q9Y4P3,P07602,Q9UBM7,Q9NZJ7,O43681,O95202,Q96A33,P47985 12 +Abnormal morphology of the conjunctival vasculature 0.6310593993355211 1.5169636119826035 0.129275871416324 1.0 0.3199870530635276 7 P10619,Q13315 2 +Abnormal atrioventricular valve morphology 0.4421946907071619 1.5163389384957089 0.1294336704390717 1.0 0.3200987881021034 38 O75844,Q96L58,P51812,P04062 4 +Hypointensity of cerebral white matter on mri 0.6359879234454361 1.5153597272966064 0.1296813303425046 1.0 0.3203080599528317 6 P07602 1 +Ectopic kidney 0.5332139445792831 1.513855298312628 0.1300625438110094 1.0 0.3210789471551274 18 O15360,Q9Y4P3,Q13426,Q9UHX1 4 +Abnormality of small intestinal villus morphology 0.6302679549781564 1.5130238407979686 0.130273603128959 1.0 0.3213960025926367 7 Q6PGP7,Q13277 2 +Peroneal muscle atrophy 0.6106648074063137 1.512102508389169 0.1305077868423014 1.0 0.3215009280313495 5 Q96RL7 1 +Abnormal size of the clitoris 0.5329364118619677 1.5120927156191846 0.1305102777156963 1.0 0.3215009280313495 18 O14974,Q13535,Q9Y619,O75381,Q9UBM7,P16435,P40855,P53701,P31939 9 +Dysmetria 0.4085218213747873 1.510444336385296 0.1309300827147606 1.0 0.322022850340274 58 Q9Y4P3,O14773,Q8IV08,O43292,O75503,Q13426,Q9NPL8,Q6P4A7,Q6DKK2 9 +Preaxial hand polydactyly 0.6109944548281845 1.5025986411890206 0.1329425740086063 1.0 0.3255936736130653 10 Q9UHX1 1 +Limb dysmetria 0.5215869311552093 1.496954948409429 0.1344049809783718 1.0 0.3279650953915523 2 P21359 1 +Subcutaneous nodule 0.5378456298424356 1.4963435550018778 0.134564150499074 1.0 0.3281056247831588 17 Q13510,P49327,P11802,P01889,P06280,Q9NZ08,P21912 7 +Bradycardia 0.5776997447450112 1.4918920692800135 0.1357274420806513 1.0 0.3303419940556131 13 Q6PJG6,P51970,P0DP25,O43772,P47985 5 +High pitched voice 0.5641976000525082 1.4894570371647726 0.1363670586343244 1.0 0.3313605410120665 14 O75844,P28340,Q13426 3 +Short palpebral fissure 0.4543143097996752 1.4875533084442176 0.1368687347545769 1.0 0.3318852513934053 33 O75844,Q9Y619,Q03164,Q9UHX1 4 +Capillary malformation 0.5758474830803229 1.4814432060853555 0.1384885085509677 1.0 0.3352491839268051 13 Q9Y4P3,Q9UHX1 2 +Pathologic fracture 0.5280173295538436 1.4808162399052294 0.1386555477715656 1.0 0.3353428812840676 18 P04062,O15269,Q96L58,Q13126,Q14108 5 +Retinopathy 0.4638303552290204 1.48027600292268 0.1387996046416706 1.0 0.3353839711670142 29 P49327,O43819,P01889,Q9Y6B6,Q9NZ08,Q15555,P51648,O95202 8 +Abnormal neuron morphology 0.4661108249716441 1.479844920375072 0.1389146376100736 1.0 0.3353839711670142 28 Q15165,Q99720 2 +Corneal dystrophy 0.6042917463218549 1.479811724104687 0.1389234989700369 1.0 0.3353839711670142 5 P12235 1 +Glomerulopathy 0.600220099598884 1.478440992297554 0.1392897801869461 1.0 0.335791036146977 11 P49327,P01889,P06280,Q14108,Q9NZ08 5 +Parkinsonism with favorable response to dopaminergic medication 0.6118930184904733 1.4763998307832225 0.1398365881189898 1.0 0.3366593624234195 9 P04062,P07602 2 +Pseudoepiphyses 0.6224108467086761 1.4738574703430902 0.1405199707554842 1.0 0.3376882290436855 7 O95202,P51812 2 +Biliary cirrhosis 0.6161458892909358 1.469352533154462 0.1417371948584147 1.0 0.3403157660528139 8 Q14739,P09601 2 +Aortic regurgitation 0.4709100168693855 1.4674892572745737 0.1422430095070728 1.0 0.3413538337654236 27 P49327,Q9UHX1,P01889,O75844,Q6PGP7,Q6ZXV5,Q9NZ08 7 +Nasogastric tube feeding in infancy 0.5979313733132496 1.4662271817564196 0.1425864057772936 1.0 0.3416614030840148 11 P07602,Q9UHX1 2 +Optic neuropathy 0.4997540143475766 1.4644501021801883 0.1430710071974059 1.0 0.3416614030840148 22 Q9P032,Q96CU9,P03886,Q9NPL8,Q9P0J0,O43676,Q86Y39 7 +Functional motor deficit 0.3456037706229795 1.4640905876018058 0.1431691986882399 1.0 0.3416614030840148 147 P15289,P42858,Q9H9S5,Q99720,P21912,Q13510,Q96RL7,Q15041,Q92974,Q9NR77,O43292,P12235,P23786,Q9NWM8,P04062,P13473,P03886,Q9Y2R0,P07602,P00403,Q9NSD9,Q15067,O14773,Q15907,Q9NZJ7,Q9H2D1 26 +Abnormal large intestine morphology 0.3876488115526085 1.462219648592545 0.1436810289713277 1.0 0.3419504092808729 79 P49327,Q13546,P42766,P49748,Q5HYI8,Q9Y4P3,P62847,Q8TAA9,Q07812,O75844,P28340,P51812,Q6PGP7,P08183,O14965,Q07864,P21912 17 +Limited elbow movement 0.4324574310741385 1.4615246612850876 0.1438715127718444 1.0 0.3419504092808729 39 Q13535,O95613,P50402,Q96L58,Q96AY3,P37268,Q7LGA3,P48651,P16435,Q15427,Q9BTV4,P23786 12 +Colorectal polyposis 0.6198418375684647 1.461030828553448 0.1440069812791535 1.0 0.3419504092808729 7 P28340,P21912 2 +Aqueductal stenosis 0.6196451448812148 1.4600483716072012 0.1442767802834916 1.0 0.3423441885582749 7 Q15427 1 +Visual hallucinations 0.6002042461493526 1.4590679196703022 0.144546414780696 1.0 0.342738761835701 5 P04062 1 +Inflammation of the large intestine 0.5456611675917905 1.4589073502723062 0.1445906098144584 1.0 0.342738761835701 15 P49327,Q13546,P01889,P49748,Q6PGP7,P08183 6 +Axonal degeneration 0.6192914214978925 1.4582814222675682 0.1447629887608394 1.0 0.3428318335655322 7 Q6DKK2,Q9BQT8,Q8TB36 3 +Furrowed tongue 0.5999789324160774 1.457923736701357 0.144861565111448 1.0 0.3428562564991275 5 Q15042,P21912 2 +Generalized onset motor seizure 0.4023386289922489 1.4559438127618072 0.1454081526785373 1.0 0.3437996322363789 59 Q13510,P27635,Q96N67,Q6PJG6,P04062,P16278,Q9Y619,P03886,P07602,Q9NZJ7,P43034,Q01105,Q96N66,P21912 14 +Renal hypoplasia aplasia 0.3828755436124787 1.4527381414833118 0.1462964727160307 1.0 0.3455482522819922 90 Q15392,Q9NWS8,P42766,P21964,Q9UHX1,Q9Y4P3,Q86XL3,P62847,Q7LGA3,Q9P2D1,Q8TAA9,Q9UBM7,Q6PGP7,Q13426,P42695,P16435,O15360,Q15427 18 +Abnormality of the upper respiratory tract 0.3718723232061486 1.450277754592885 0.1469810798550275 1.0 0.3469888704301107 107 Q13510,Q03519,Q13277,P16278,Q9UHX1,Q15165,Q13315,P07602,Q9NZJ7,Q03518,P16435,Q14739,Q96HY6,Q15427,P54802,Q13432 16 +Increased serum pyruvate 0.4432686138584857 1.4445063099112032 0.1485966060917924 1.0 0.3493825060235161 35 Q70HW3,Q96CU9,P03886,P22695,Q9NPL8,O43676,Q86Y39,P21912 8 +Hypotension 0.4737348931684751 1.4423466751426122 0.1492045990110948 1.0 0.3504573139562925 26 P15289,P04062,Q13423,O43681,P07602,Q9NZJ7,O43772 7 +Thick hair 0.6208624425651751 1.44106537163977 0.1495662153427672 1.0 0.3509518366073215 6 Q9Y487 1 +Birth length less than 3rd percentile 0.5724796256351447 1.4391768363714967 0.1501004265217864 1.0 0.351849940272563 4 Q99741,Q9Y619 2 +Peripheral axonal neuropathy 0.4005804016372469 1.4378250092671503 0.1504837114472528 1.0 0.3525705110357723 59 Q15067,Q96RL7,O15269,P03886,P07602,Q8IV08,O76024,Q9NZJ7,Q13426,P00403,Q9NVI7,P12235 12 +Cutis laxa 0.455862797727561 1.4368934089657548 0.1507482830169126 1.0 0.3529286906750892 30 Q96L58,Q9Y4P3,Q15904,P38435,P51812,Q9Y487 6 +Aplasia hypoplasia of toe 0.442337395146165 1.4367518468833882 0.150788517216972 1.0 0.3529286906750892 35 Q13510,P42858,Q9UHX1,P55011,Q7LGA3,Q9P2D1,P13073,Q03164,O95202,Q15427 10 +Abnormal sella turcica morphology 0.6041400892793155 1.4363828656628013 0.1508934260293051 1.0 0.3529964034905093 9 P16278 1 +Abnormal labia minora morphology 0.6095398671014947 1.4358058223731345 0.1510576025949954 1.0 0.3532026279095867 8 Q9Y619,P31939 2 +Megaloblastic anemia 0.6094631249960809 1.4354157304438897 0.1511686660751103 1.0 0.3532845184028987 8 P00374 1 +Abnormality of pancreas physiology 0.4205648973046992 1.4341876960441962 0.1515187072733483 1.0 0.353924541976861 44 P49327,P53985,Q9UJW0,Q9UHX1,Q5HYI8,P03886,Q15904,P09601,P00403,Q14739,Q9NZ08 11 +Vertebral segmentation defect 0.452801328396168 1.4323452114558388 0.1520450500632226 1.0 0.3547972388717892 31 Q9UHX1,Q9Y619,Q9Y4P3,Q9P2D1,Q8TAA9,P16435,O95202 7 +Episodic tachypnea 0.6030965897612464 1.430989692683618 0.1524331692204881 1.0 0.3551793057234116 9 P22695 1 +Titubation 0.5972777613693971 1.4306365311490885 0.1525344119736125 1.0 0.3552188522403959 10 Q99720,Q6PJG6,Q96RL7 3 +Coarse hair 0.4998296700264818 1.4291074042645655 0.1529733657062468 1.0 0.3555348959836032 21 P51812,P54802,Q9Y487 3 +Elevated hepatic transaminase 0.3722093409419121 1.4250312762795347 0.1541481604292245 1.0 0.3571931936928564 104 Q5HYI8,Q9Y619,O43772,Q2TAA5,Q8N511,Q13510,Q96RL7,Q9Y6B6,Q14739,P12235,P23786,Q16625,Q13315,Q9NSD9,P10253,Q15067,Q16836,Q5XKP0,P49748,P22695,P28340 21 +Abnormal mitochondria in muscle tissue 0.4938520606365508 1.423814944973831 0.1545000483058378 1.0 0.3578301218489146 22 Q9P032,Q96CU9,P03886,Q9NPL8,P00403,O43676,Q86Y39 7 +Abnormal saccadic eye movements 0.4771216649157565 1.4235208062343552 0.1545852349872405 1.0 0.3578490292729046 25 Q8IV08,Q96RL7,O14773,P04062 4 +Abnormal cerebral artery morphology 0.5114463059170565 1.4222338465327409 0.1549583761014306 1.0 0.3585341709996247 19 P38435,Q9NSD9,P05067,P10253 4 +Hyperinsulinemic hypoglycemia 0.6167854933376828 1.420985109638553 0.1553210883420632 1.0 0.3591945129105156 6 Q16836 1 +Abnormal forearm bone morphology 0.4823633398646647 1.4199207106590777 0.1556307657204707 1.0 0.3595527287604709 24 Q13535,Q96L58,Q9P2D1,P16435,O15360,Q15427 6 +Flared iliac wing 0.6111742377235221 1.4176851237680066 0.1562827151931412 1.0 0.3608794705702455 7 P16278 1 +Abnormality of coordination 0.3110457018154403 1.4142824740938658 0.1572789807005772 1.0 0.3625859862164371 332 P15289,P42858,Q6PJG6,Q9P032,Q96CU9,Q96IX5,Q9Y619,Q9Y4P3,P14854,Q8IV08,Q9H9S5,Q13426,Q14108,Q9P0J0,Q99720,O43676,O95202,Q6DKK2,Q2TAA5,P21912,Q13510,Q96RL7,P16278,Q9Y287,Q92974,Q9NR77,O43292,P00374,P50897,O43681,P12235,Q86Y39,O95470,P04062,P03886,Q13315,P07602,Q9P2D1,O76024,O14949,Q9Y6M9,P00403,Q01105,Q9Y487,P05067,O15118,Q15067,P49327,Q5XKP0,O14773,Q15907,Q9NZJ7,O75503,Q9NPL8,Q6P4A7,Q9NVI7,Q9NZ08,Q7KZN9 58 +Recurrent gastroenteritis 0.5372045520863847 1.414029145271891 0.1573533451992408 1.0 0.3625859862164371 3 Q96AX1,P54132 2 +Abnormality of upper limb epiphysis morphology 0.5244961658073067 1.4129530512254602 0.1576695288739289 1.0 0.3625859862164371 17 Q13535,O95613,P51812,P16435,O95202 5 +Mandibular aplasia 0.5674519063193236 1.412742164939199 0.1577315489740434 1.0 0.3625859862164371 4 P53701,Q9Y619 2 +Shuffling gait 0.5994735899854701 1.4122522785321994 0.1578756922819335 1.0 0.3625859862164371 9 P04062 1 +Ichthyosis 0.4363503466300035 1.411706855222404 0.1580362940353605 1.0 0.3625859862164371 36 O95470,P04062,Q15800,O75381,Q9P2D1,P51648,Q14691,P48449,Q9BTV4 9 +Triphalangeal thumb 0.4811291850970206 1.411102847085791 0.158214290645253 1.0 0.3628151995744549 24 Q15427,P42766,P62847 3 +Eeg with spike wave complexes 0.5500460993143916 1.4070142043233935 0.1594231768471288 1.0 0.3648670343013598 14 Q14108 1 +Dermal atrophy 0.4542161998424173 1.4055041862097843 0.159871405372485 1.0 0.3657127274054974 29 P28340,O75844,Q15392,Q96L58 4 +Pulmonary fibrosis 0.4962105118283364 1.4045657768459272 0.1601504392807018 1.0 0.3660090374021311 21 P49327,Q9UJW0,P04062,Q8IZA0,P09601 5 +Sporadic 0.4540923732782524 1.4045386994869316 0.1601584961339932 1.0 0.3660090374021311 29 P42345,P04062,Q9P2D1,P51812,O95202,P21912 6 +Abnormal bleeding 0.3649869767624675 1.4039491616157516 0.1603339887756214 1.0 0.3662299468296643 111 Q9UHX1,P38435,Q14108,P21912,Q14739,O15360,P11117,P23786,Q9NWM8,P21964,Q16625,P04062,O76024,O75844,P51798,Q13126,Q6ZXV5,Q9Y487,P05067,P49327,Q96L58,O00203,P50570,Q9NZ08 24 +Tapered finger 0.4199798408692339 1.4035854390059914 0.1604423335883846 1.0 0.366297337519231 42 P42892,Q15907,P51812,Q06136,P23786 5 +Delayed epiphyseal ossification 0.5884260865717895 1.3991606718523537 0.1617648071189061 1.0 0.3689539979746873 5 Q96L58 1 +Abnormality of the intrinsic pathway 0.585275942572221 1.3985311405402712 0.1619536280897553 1.0 0.3692034132016699 11 Q9Y487 1 +Abnormality of the biliary system 0.3558350786849045 1.3958875889554585 0.1627483486127643 1.0 0.3702883583030867 120 P15289,Q5HYI8,Q9Y4P3,P09601,Q14108,O95202,Q13510,Q15904,Q9UBM7,Q6PGP7,P00374,Q14739,O43681,Q96A33,P47985,P21964,Q16625,P04062,P07602,Q9NSD9,O75845,P22830,O15118,Q5XKP0,P49748,Q9NZJ7 26 +Abnormal gallbladder morphology 0.442794462712711 1.393868540548019 0.1633573058176984 1.0 0.3714919446054954 33 P15289,P21964,P04062,O75845,Q9Y4P3,P07602,Q9NZJ7,O43681,Q96A33,P47985 10 +Abnormality of hair texture 0.3977981098953066 1.3928980733069654 0.163650615155239 1.0 0.3719768874810374 57 P42345,Q9UM00,Q01968,O95613,P46778,P62266,O75844,P51798,P51812,Q6PGP7,Q9BPU6,Q9NVI7,P54802,Q9Y487,Q96A33 15 +Abnormal muscle fiber morphology 0.3841717001848764 1.3922610210407578 0.1638433704474478 1.0 0.3722329090947884 70 Q70HW3,P05067,P03886,P00403,Q99720,O43676,P12235,Q9H2D1,P23786 9 +Stenosis of the external auditory canal 0.6050419894962219 1.386957949792028 0.165454585541152 1.0 0.3749765875239962 7 O95202,P16435 2 +Abnormal cartilage morphology 0.5589833719801922 1.3860021220353231 0.1657462555228597 1.0 0.3754544627787451 13 Q9UHX1 1 +Clonus 0.4358680457161994 1.382766884742829 0.1667363559468095 1.0 0.3771456230422966 35 P42858,Q6PJG6,Q9Y619,P07602,Q9H9S5,Q9NZJ7,Q9BQT8,Q99720 8 +Soft skin 0.5937098849573238 1.3824054762018074 0.1668472355980581 1.0 0.3772127769287484 9 Q96L58,Q13126 2 +Ventricular fibrillation 0.598779699828361 1.381031066373358 0.1672694088293924 1.0 0.3779833041932671 8 P49748,Q9HD47,Q99959,P46976 4 +Spastic paraparetic gait 0.584464701800811 1.378971175058366 0.1679036414276271 1.0 0.378949192478312 5 Q15041,Q15043 2 +Hypothermia 0.5815586045681334 1.3785986957510497 0.1680185189099059 1.0 0.378949192478312 11 P49748,P03886,O43772,P47985 4 +Sick sinus syndrome 0.5843102756564272 1.3781837499497511 0.168146563092979 1.0 0.378949192478312 5 Q9HD47,Q99959 2 +Immune dysregulation 0.5008751458576497 1.3770269322206306 0.1685039212918067 1.0 0.378949192478312 2 P16885 1 +Atrophy degeneration involving the caudate nucleus 0.5606538304168478 1.3769444981345154 0.1685294081469717 1.0 0.378949192478312 4 P42858 1 +Abnormal st segment 0.6077806938687198 1.376560384034458 0.1686482061568428 1.0 0.378949192478312 6 Q9HD47,Q99959,P46976 3 +St segment elevation 0.6077806938687198 1.376560384034458 0.1686482061568428 1.0 0.378949192478312 6 Q9HD47,Q99959,P46976 3 +Abnormality of the calf 0.3877116286070488 1.3761567069851257 0.1687731222685882 1.0 0.378949192478312 66 Q13535,P16278,Q9Y619,Q9Y4P3,Q9NR77,Q96L58,Q7LGA3,Q9P2D1,Q13126,P16435,Q96HY6,Q15427 12 +Abnormality of the spinocerebellar tracts 0.5005834305717769 1.3753327385553085 0.1690283111844386 1.0 0.378949192478312 2 O00754 1 +Spinocerebellar tract degeneration 0.5005834305717769 1.3753327385553085 0.1690283111844386 1.0 0.378949192478312 2 O00754 1 +Abnormal cranial nerve physiology 0.3808477358091007 1.3751548485527243 0.1690834429633105 1.0 0.378949192478312 75 Q9UHX1,P01889,P51812,Q9H9S5,P21912,Q13510,Q15043,O43819,Q9NR77,O75381,P48651,P12235,O15360,Q9H5V9,Q9Y5P6,P07602,Q9P2D1,P51798,P49327,P50570,Q9NZJ7,Q9NZ08 22 +Absent forearm bone 0.6026220324297433 1.3748194505103073 0.1691874264218151 1.0 0.3789994132862841 7 O15360,Q15427 2 +Puberty and gonadal disorders 0.3201642582271002 1.371890419502446 0.1700975532929549 1.0 0.3803047317608608 174 P42858,Q13423,Q16740,P55011,Q9Y4P3,P06280,Q13426,Q14108,O95202,O95613,Q7LGA3,Q9UBM7,P49770,P48449,P16435,O15360,O95470,P04062,P03886,Q13315,Q9P2D1,O75844,P00403,Q15800,P28340,Q9BT22,Q9NVI7,Q07864 28 +Pain 0.3195978090833734 1.3707824854525517 0.1704427723637163 1.0 0.3808932758065541 183 Q13546,Q13423,Q15165,Q5HYI8,Q9Y4P3,P14854,P06280,Q9H9S5,Q14108,Q96HY6,P21912,Q13510,Q15043,P42892,Q9NR77,Q14739,P12235,P23786,Q14566,P21964,P04062,O15269,P07602,O75844,P51798,Q70HW3,P49327,Q15800,Q9BUK6,P49748,Q8TAA9,P50570,Q9NZJ7,Q9NZ08,Q9BTV4,Q07864 36 +Kyphosis 0.3344911236910242 1.3675267629463872 0.171460254478188 1.0 0.3824312733104472 155 P42858,Q9P032,Q9UHX1,P55011,Q9Y4P3,P51812,Q9H9S5,P10412,Q14108,O95202,P21912,P16278,Q9NR77,Q7LGA3,Q9UBM7,Q14739,Q9NWM8,P04062,P51648,O75844,Q9Y487,Q8TB36,Q96L58,Q96AY3,P28340,Q9BT22 26 +Malrotation of small bowel 0.5586896292787218 1.3665904820812491 0.1717537022111339 1.0 0.3829019675973744 4 O95202 1 +Progressive proximal muscle weakness 0.49854142357061 1.3634700228264982 0.1727344258140886 1.0 0.3847301266326148 2 Q7Z392 1 +Bruxism 0.5952024032810694 1.362787832489209 0.1729493869251808 1.0 0.3847919764076287 8 P42858 1 +Hepatic encephalopathy 0.557928649141169 1.3625778560864408 0.1730155916305502 1.0 0.3847919764076287 4 A2RRP1,Q6NUQ1 2 +Abnormal upper limb bone morphology 0.3626502918775587 1.361982921249464 0.173203275051661 1.0 0.3850250793732139 110 P42858,Q9UHX1,P55011,Q9Y4P3,P51812,O95202,P16278,O95613,O15228,Q7LGA3,Q9UBM7,P16435,Q14739,O15360,O00116,Q9P2D1,O75844,P51798,Q15427,Q13535,Q96L58,Q96AY3 22 +Leg muscle stiffness 0.4979579929988472 1.3600796211244182 0.173804729186882 1.0 0.3859927207467753 2 Q6PI48 1 +Areflexia of lower limbs 0.4944240576611443 1.3594389852093944 0.174007524524391 1.0 0.386113580045429 20 Q15067,Q96RL7,Q15041,Q9NR77,P50570,P12235 6 +Abnormality of the abdominal organs 0.2951710593964273 1.3584067613968431 0.1743346499926561 1.0 0.3864307174932635 368 P15289,Q15392,Q13546,P53985,Q9P032,Q9UHX1,Q96CU9,Q5HYI8,Q9Y619,Q9Y4P3,P09601,Q13426,Q14108,O43772,O43676,O95202,Q96HY6,P21912,Q8N511,Q13510,Q96RL7,P16278,Q9Y6B6,Q15904,Q9UBM7,Q6PGP7,P00374,Q14739,O43681,P12235,O15360,Q86Y39,Q96A33,P23786,P47985,Q9NWS8,Q16625,P04062,P21964,P03886,Q13315,P07602,Q9P2D1,O76024,P51798,Q9Y6M9,P00403,Q9NSD9,O75845,P10253,P22830,Q15067,O15118,P49327,Q16836,Q5XKP0,Q9UJW0,P49748,O00203,P10619,P28340,Q9NZJ7,Q96KP1,Q9BT22,Q9NPL8,Q9NVI7,Q9NZ08,P54802,Q7KZN9 69 +Abnormal circulating non proteinogenic amino acid concentration 0.5991486415021301 1.3573851808602222 0.1746588543996092 1.0 0.3869647293946517 7 P05067,P03886 2 +Confusion 0.5012902137900737 1.355840647019296 0.1751498753788589 1.0 0.3877254310044864 19 P05067,P49327,P11166,Q16836,P01889,Q9Y619,P26358,Q9NZ08 8 +Abnormality of limb epiphysis morphology 0.4381250669509007 1.3557279535868745 0.1751857418984272 1.0 0.3877254310044864 33 Q13535,O95613,Q96L58,Q7LGA3,P51812,P16435,O95202 7 +Infectious encephalitis 0.5987768141186823 1.3555180478001478 0.1752525624428371 1.0 0.3877254310044864 7 Q14739,P49327,Q9NZ08 3 +Dysgenesis of the cerebellar vermis 0.4962077012835553 1.3499057088193922 0.1770462302664301 1.0 0.3910015147705706 2 Q10713 1 +Abnormality of long bone morphology 0.3187432645757218 1.3498316411608748 0.1770699929137495 1.0 0.3910015147705706 185 P42858,Q9UHX1,P55011,Q9Y619,Q9Y4P3,P38435,P51812,Q96HY6,O95202,P16278,O95613,Q9NR77,O15228,Q9UBN7,Q7LGA3,Q9UBM7,P16435,Q14739,O15360,O00116,Q9P2D1,O75844,P51798,Q13126,Q15427,Q9Y487,Q13535,Q96L58,Q96AY3,P37268,Q07864 31 +Abnormal lung lobation 0.5397373832718713 1.3467150784041868 0.1780720141196057 1.0 0.392468015939131 14 Q14739,Q9UHX1,Q9UBM7 3 +Ankle clonus 0.5637647276848008 1.3452609009211078 0.1785409952813343 1.0 0.3933150612029775 12 P42858,P07602,Q9NZJ7 3 +Agitation 0.4367338763794202 1.344347102914447 0.1788361705530898 1.0 0.3933717319803669 33 P05067,P42892,P04062,Q15165,P48449 5 +Vertebral hypoplasia 0.563533433916732 1.3439830621154203 0.1789538641621075 1.0 0.3933717319803669 12 Q14739,Q96HY6,P16278 3 +Perimembranous ventricular septal defect 0.6011663913848908 1.3438711246731796 0.1789900648744071 1.0 0.3933717319803669 6 Q9UHX1 1 +Abnormal vascular morphology 0.3224240850303254 1.3431338011356275 0.1792286523507362 1.0 0.3937098434144305 248 Q15392,P42858,Q9UHX1,P55011,Q9Y4P3,P38435,P21912,Q13510,P42892,P16278,O95613,Q7LGA3,P0DP25,Q9UBM7,Q6PGP7,P48651,O15360,P47985,Q9NWM8,P21964,P42766,P04062,P03886,P07602,Q99959,Q9P2D1,O75844,P51798,Q6ZXV5,Q15427,Q9NSD9,Q9Y487,O75845,P10253,P05067,O15118,O14678,P17900,Q96L58,P62847,P10619,Q9NZJ7,Q9NZ08,P51571 44 +Psychotic mentation 0.5949331464999037 1.336208536375851 0.1814811216911347 1.0 0.3977175902721754 7 P03886 1 +Focal t2 hyperintense brainstem lesion 0.4980130026360059 1.3343655008371789 0.1820841006413491 1.0 0.3988508871191458 19 Q9P032,Q96CU9,P03886,Q9NPL8,O43676,Q86Y39 6 +Azoospermia 0.5249358795692436 1.3340003346708302 0.1822037468495307 1.0 0.3989248858920453 15 O15360,P04062,Q13423 3 +Aplasia hypoplasia of the ulna 0.5373577813363637 1.332770490652431 0.182607132475647 1.0 0.3993216014626186 14 O15360,Q15427 2 +Open mouth 0.4400615468054207 1.330670775655851 0.1832973630901349 1.0 0.4003622657569058 31 P51812,P04062 2 +Ambiguous genitalia 0.4751964329212109 1.3304280048992807 0.1833772926239121 1.0 0.4003622657569058 23 Q15392,Q8TAA9,P16435,Q9UBM7 4 +Hypoplasia of the radius 0.5832317058674071 1.3280370666542272 0.1841658620114712 1.0 0.4013295473289378 9 Q15427 1 +Inappropriate behavior 0.5235142719056792 1.325403068592063 0.1850374997889377 1.0 0.4027709487752666 15 P17900,Q9NZJ7,P07602 3 +Toxemia of pregnancy 0.5739573337673753 1.3253343578624437 0.1850602781931245 1.0 0.4027709487752666 5 O43772 1 +Slow saccadic eye movements 0.5714317157831426 1.324201691409888 0.185436069273887 1.0 0.4033408135985388 11 Q8IV08,P04062 2 +Depressed nasal tip 0.5504584304658158 1.3231540083014153 0.1857841671169202 1.0 0.4039088630908804 4 Q03164 1 +Inguinal hernia 0.3745876960795785 1.3228118275715697 0.1858979629378139 1.0 0.4039137185938494 83 Q9NWM8,P21964,O14678,Q6PJG6,Q9UM00,P16278,Q9UHX1,Q9UL01,Q9Y4P3,P51970,Q15555,P51812,Q6PGP7,Q13426,P48651,P43034,Q9NSD9,Q9Y487 18 +Abnormality of the metacarpal bones 0.4166157936853554 1.3223632676142376 0.1860472143329397 1.0 0.4039137185938494 39 P16278,O95613,Q96L58,Q9UBM7,P51798,P51812,P16435,Q14739,O95202 9 +Nail dysplasia 0.4286019422590277 1.3219103934242735 0.1861979910601774 1.0 0.4040522496336218 35 P42892,Q13535,P51812,P16615,O95202 5 +Knee flexion contracture 0.4453803076083978 1.3198786536438232 0.1868755356352116 1.0 0.4053332112797354 28 P27635,P49902,Q86XL3,Q96AY3,Q7LGA3,P48651,P37268,P23786,P21912 9 +Profound sensorineural hearing impairment 0.5496591428848003 1.31893244552437 0.1871916979440016 1.0 0.4056402185857423 4 Q9NR77 1 +Aplasia hypoplasia of the extremities 0.318461758451487 1.318029273084945 0.1874938487596482 1.0 0.406105557733019 195 Q15392,P42858,Q9UHX1,P55011,Q9Y619,P38435,P51812,Q13426,Q96HY6,O95202,Q13510,O95613,O15228,Q9UBN7,Q7LGA3,Q9UBM7,P13073,P16435,Q14739,O15360,Q96A33,P42766,O00116,Q9P2D1,O75844,P51798,Q15427,P42345,Q13535,Q96L58,Q96AY3,P62847,Q03164,Q07864 34 +Thyroiditis 0.5856164983976874 1.313831740167127 0.1889028337604075 1.0 0.4085859244184606 8 P49327,P50851,Q9P2D1 3 +Hydrops fetalis 0.4045540110946041 1.3131302239886673 0.1891390709826175 1.0 0.4087567625348192 46 Q13510,P42766,P04062,P16278,P62847,P10619,Q14739 7 +Broad palm 0.5903320407929471 1.3130746985077286 0.1891577786159839 1.0 0.4087567625348192 7 P51812 1 +Abnormal circulating pyruvate family amino acid concentration 0.4872755149892741 1.311544557937882 0.1896738501168879 1.0 0.4096814075514001 20 Q5XKP0,P03886,P22695,Q99797,Q9P0J0 5 +Spastic hyperactive bladder 0.5941403096262485 1.309100320403734 0.1905003707528385 1.0 0.4107028874792055 6 P04062 1 +Subcutaneous hemorrhage 0.4066948155060863 1.3064781813933803 0.1913899941005219 1.0 0.4120472254824026 44 Q9NWM8,Q16625,P04062,Q96L58,P38435,Q13126,Q14108,O15360 8 +Contractures of the joints of the lower limbs 0.3909921724888209 1.3043375806629147 0.1921185072661044 1.0 0.412828053400869 54 P27635,Q9BTV4,Q9Y5P6,P49902,P50402,Q86XL3,Q96AY3,Q8IZA0,Q7LGA3,Q9H9S5,P48651,Q99720,P37268,P23786,P21912 15 +Ureteral duplication 0.5884058573591618 1.3033843556558813 0.1924435747948227 1.0 0.4129759115458414 7 O75844,P23786 2 +Poor head control 0.3745780711843485 1.3020793943133742 0.1928892463353502 1.0 0.4131689435103905 74 Q9NWM8,Q5XKP0,Q96CU9,P17900,P03886,P07602,P13073,Q9NZJ7,P00374,Q9P0J0,Q9NPL8,O43676,Q86Y39,P21912 14 +Spinal muscular atrophy 0.5671462757604918 1.3011443456601657 0.1932090510382522 1.0 0.4135378750086821 11 Q99720 1 +Cerebral dysmyelination 0.57732265886752 1.297323157351116 0.1945200197588734 1.0 0.4155126491033223 9 P07602 1 +Abnormality of the abdominal wall 0.3423133428214457 1.2968162729168538 0.1946944102120471 1.0 0.4156940394509058 129 Q6PJG6,Q9UHX1,Q9Y4P3,P51812,Q13426,Q96HY6,Q9UM00,P16278,Q9UL01,Q15555,Q9UBM7,Q6PGP7,P48651,Q14739,P43034,O15360,Q9NWM8,P21964,Q9P2D1,O75844,Q15427,Q9NSD9,Q9Y487,P42345,O14678,P51970 26 +Diaphyseal thickening 0.5447677655015628 1.2930854711921205 0.195981499508439 1.0 0.4174828274718971 4 Q14739 1 +Abnormal visual electrophysiology 0.3958814292723099 1.2923603771688408 0.1962323717260796 1.0 0.4178256640877021 50 P15289,Q15067,Q92974,P14854,P07602,O14773,P51798,Q9NZJ7,O75503,P50897,P12235 11 +Abnormality of the mitochondrion 0.3681734106735398 1.2915545123134844 0.1965114654633137 1.0 0.4178963883914303 93 Q96CU9,Q9P0J0,O43772,O43676,P21912,Q9UBX3,P13073,P12235,Q86Y39,Q9Y584,P23786,P03886,Q9Y2R0,P00403,Q70HW3,Q16836,P49748,Q9NPL8,Q7KZN9 19 +Varicose veins 0.5673369942372997 1.2914853548486858 0.1965354301840884 1.0 0.4178963883914303 5 P04062 1 +Venous insufficiency 0.5673369942372997 1.2914853548486858 0.1965354301840884 1.0 0.4178963883914303 5 P04062 1 +Generalized hypotonia 0.2913317471887937 1.287843189617524 0.1978005545052235 1.0 0.4202018181212932 370 P15289,Q9P032,Q9UHX1,Q96CU9,P51571,P55011,Q9Y619,P14854,P51812,Q9H9S5,Q9P0J0,O43772,O43676,O95202,P31939,P21912,Q8N511,Q92974,Q9NR77,O15228,Q9UBM7,O43292,Q9UBX3,P13073,P00374,P50897,P49770,P48651,O43681,P12235,P11117,Q86Y39,Q96N66,Q96A33,P23786,O95470,Q9NWS8,P07602,Q13409,P62266,O14949,P51798,Q9Y6M9,Q01105,Q9NSD9,Q9Y487,O75845,P10253,Q70HW3,O15118,O14678,P42345,Q16836,Q5XKP0,P17900,Q96L58,Q15907,Q9NZJ7,Q03164,Q9BT22,Q99797,Q6P4A7,Q9NVI7,Q7KZN9 64 +Hip dislocation 0.3806147618125876 1.2872118318965664 0.1980204643631948 1.0 0.4203192102582198 65 Q13535,Q9UHX1,P55011,Q96L58,O15360,O75844,Q9H9S5,O95202,Q15427,Q9Y487,Q96A33 11 +Hyperacusis 0.5803047399089748 1.2866653958058312 0.1982109392799922 1.0 0.4204968145638557 8 P17900 1 +Dyspnea 0.3637711925581012 1.2838368783715977 0.1991990370007466 1.0 0.421739990204156 100 Q13510,P04062,Q9UHX1,Q15165,P49748,P03886,Q96L58,P07602,O75844,Q9NZJ7,P12235,P23786 12 +Hepatocellular adenoma 0.4848308051342069 1.2836889472055388 0.1992508132798076 1.0 0.421739990204156 2 O00330 1 +Congenital craniofacial dysostosis 0.4848308051341925 1.2836889472054551 0.1992508132798369 1.0 0.421739990204156 2 Q6NUK1 1 +Advanced eruption of teeth 0.5525847900690207 1.2834166926816934 0.1993461287478801 1.0 0.4217495966132291 12 P51812 1 +Cerebellar vermis atrophy 0.5284880225838946 1.280719949696659 0.2002920499543212 1.0 0.4233652702856126 14 Q13426 1 +Abnormality of toe 0.3144952513769541 1.2780933276934234 0.2012165212917849 1.0 0.4243540435413675 184 P42858,Q9UHX1,Q9Y4P3,P51812,Q99720,O95202,Q13510,P49902,Q9NR77,Q7LGA3,P13073,Q14739,O15360,Q96A33,P23786,P04062,Q9P2D1,O75844,Q15427,Q13535,Q96L58,Q15907,Q03164,P37268 24 +Delayed closure of the anterior fontanelle 0.5515212097147656 1.277525725645862 0.2014167040249646 1.0 0.4244680619286331 12 P51812 1 +Mandibular prognathia 0.4048497317353549 1.2774219778915592 0.2014533096325088 1.0 0.4244680619286331 43 P51812,Q9UHX1 2 +Abnormal glycosylation 0.4673742236958998 1.27518411421215 0.2022440826902887 1.0 0.4257857737449683 23 Q8N511,Q9BT22,Q2TAA5,Q9Y487,P51571 5 +Abnormality of digestive system morphology 0.3183274160946795 1.275133512739978 0.2022619893790669 1.0 0.4257857737449683 258 Q15392,Q13546,Q13277,Q5HYI8,P55011,Q9Y4P3,P06280,P09601,P51812,Q9H9S5,Q13426,O95202,P21912,P42892,Q9Y6B6,Q9UBM7,Q6PGP7,P48651,P16435,Q14739,P08183,O15360,Q96A33,Q14566,P21964,P42766,P04062,P03886,Q9P2D1,O76024,O75844,P00403,Q6ZXV5,Q15427,Q9NSD9,O14965,P49327,P42345,Q9UJW0,P49748,P62847,Q8TAA9,Q07812,P50570,P28340,Q9BT22,P16615,Q9NZ08,Q07864 49 +Synostosis involving digits 0.5636637338727698 1.2726896320894492 0.2031281981379917 1.0 0.4270287821489184 5 O95613,P48651 2 +Lissencephaly 0.3846217815368368 1.2723026095607426 0.203265621771137 1.0 0.4271244137262337 59 Q15392,Q9NWS8,Q16625,Q9Y5P6,Q13535,P43034,Q86XL3,P78527,Q00535,Q9H9S5,Q96SN8,P42695,Q6ZXV5,Q8NAT1,O43505,Q16134,Q9Y487,P23786 18 +Elbow flexion contracture 0.4368522083399745 1.2695724602171532 0.2042369644515167 1.0 0.428971490434786 29 Q13535,Q96L58,Q96AY3,Q7LGA3,P48651,P16435,P37268,P23786 8 +Large hands 0.5664509711838386 1.2679252885781591 0.2048246322390237 1.0 0.429817182196253 10 P51812 1 +Ridged nail 0.581038262379042 1.2662917631279913 0.2054086448154686 1.0 0.4306536840309869 7 Q13535 1 +Abnormal corneal epithelium morphology 0.4941520940810454 1.2639004313487745 0.2062657669670142 1.0 0.432018664981567 18 P49327,P01889,P51648,O75844,Q14739,Q9NZ08 6 +Hypoglycemic seizures 0.5849080713101227 1.26335160020182 0.2064628498035583 1.0 0.432018664981567 6 Q16836,Q13423 2 +Upper limb undergrowth 0.4706564614363483 1.2631816172664732 0.2065239176472248 1.0 0.432018664981567 22 Q14739,O15360,Q15427,Q13535 4 +Abnormal renal resorption 0.5391126678342103 1.2631796202971863 0.2065246351536935 1.0 0.432018664981567 4 P16930,Q01968,O15078 3 +Abnormal pulmonary thoracic imaging finding 0.4703617366655724 1.2611324970941014 0.2072611140368829 1.0 0.433027621340976 22 Q13510,P49327,P21964,P04062,Q96L58,Q9NZ08 6 +Abnormal mitral valve physiology 0.402986332350042 1.2603010836988318 0.2075607692097929 1.0 0.4334055432578417 43 P49327,O43819,P04062,P01889,Q9UL01,Q96L58,Q9Y4P3,P06280,Q8WVX9,O75844,P51812,Q9NZ08 12 +Cranial hyperostosis 0.5367562787976307 1.2595059213132316 0.2078476528209383 1.0 0.433809611413333 13 Q96L58,P51812,Q15043 3 +Abnormality of urinary uric acid concentration 0.5088999124598914 1.2573761794359684 0.2086174506232838 1.0 0.4351136701630294 3 P00492,P00491 2 +Myoglobinuria 0.5641843980354457 1.2559213888475755 0.2091444729212777 1.0 0.435342841035957 10 P49748,Q16836,P23786 3 +Abnormal nervous system electrophysiology 0.3148330082644436 1.2534205471362887 0.2100526976228987 1.0 0.4362560720411208 195 P15289,Q15120,Q01968,Q9Y619,P55011,Q9BQE5,Q2M389,Q9H9S5,Q14108,Q99720,Q9NZ01,O95202,Q2TAA5,Q96RL7,Q9NR77,O75381,O43292,Q9UBX3,P13073,P50897,P48449,P43034,O43681,Q96N66,Q96A33,P27635,Q96N67,P21964,Q9Y5P6,O15269,P03886,P07602,P00403,Q8TB36,Q15067,P11166,O14773,Q96C86,P50570,Q9NVS9,Q9NZJ7,O75503,Q8IWS0 43 +Aplasia hypoplasia of the radius 0.4784165715779544 1.252044095826122 0.210553796534235 1.0 0.4370367008228095 20 Q13535,Q96AY3,Q9P2D1,O15360,Q15427 5 +Premature rupture of membranes 0.5825931062588391 1.251871484871781 0.2106166967589906 1.0 0.4370367008228095 6 O75844 1 +Shoulder girdle muscle weakness 0.5234003216195969 1.2508180439048036 0.2110008701579175 1.0 0.4374762702518198 14 P12235,Q9NZJ7,P07602 3 +Abnormality of the clitoris 0.4687475042630227 1.24990631233268 0.2113337732712104 1.0 0.4375507645414234 22 O14974,Q13535,Q9Y619,Q15042,O75381,Q9UBM7,P16435,P40855,P53701,P31939 10 +Aplasia hypoplasia involving the vertebral column 0.4985693783086178 1.2499020675442376 0.2113353240703732 1.0 0.4375507645414234 17 Q14739,Q96HY6,P16278 3 +Nausea and vomiting 0.3310879551701372 1.2490309823597967 0.2116537421195305 1.0 0.4378198067174261 148 Q13277,Q13423,Q9P032,Q96CU9,Q15165,Q5HYI8,Q9Y619,Q9Y4P3,P06280,O43676,Q2TAA5,P21912,P42892,Q9Y6B6,P11117,Q86Y39,Q9Y584,P23786,P03886,P07602,P00403,Q9NSD9,Q16836,P49748,P22695,Q8IZA0,Q9NZJ7,Q9NPL8,Q9NZ08,P51571 30 +Abnormal uterus morphology 0.4197914211799007 1.247835441465288 0.2120913266640156 1.0 0.4383346546623739 35 Q9UBM7,Q07812,P28340,P51812,O15360,Q15427,Q07864,P21912 8 +Congenital hip dislocation 0.4530166059115836 1.2473163895662196 0.212281510221437 1.0 0.4385326351662056 25 Q9UHX1 1 +Macrocytic anemia 0.4219298826653008 1.243643951963438 0.2136306324336003 1.0 0.4411235192384477 34 P42766,P00374,P62847 3 +Abnormality of the septum pellucidum 0.3997464538218857 1.2421229333476276 0.2141912083095389 1.0 0.4417806753874657 44 O14974,Q15392,P55011,P43034,Q13409,Q2M389,Q96C86,Q6P1N0,Q9H9S5,P53701,P48651,O43505,Q8NAT1,Q9NZ01,O95202,Q96N66,P51571 17 +Left ventricular hypertrophy 0.4575866190558601 1.242057595216995 0.2142153126115453 1.0 0.4417806753874657 24 P10253,P03886,P06280,P00403,P12235,P21912 6 +Bradykinesia 0.4573584699219131 1.2404127067376638 0.2148227834827789 1.0 0.44279798228083 24 Q5JPH6,O75569,P42858,Q96RL7,P04062,O75165,Q96IX5,Q6DKK2,P12235,Q15043 10 +Accessory spleen 0.570633996885062 1.237149460507838 0.2160316003359166 1.0 0.4448948648761829 8 Q96KP1,O95202 2 +Eyelid myoclonus 0.5597743109285704 1.232554409392857 0.2177420552012727 1.0 0.4482186922751942 10 P00374 1 +Aplasia hypoplasia involving forearm bones 0.4612500737012452 1.231838334028886 0.2180094804618444 1.0 0.4485704367695878 23 Q13535,Q96AY3,Q9P2D1,O15360,Q15427 5 +Osteolysis 0.4298584406271826 1.2310877625970966 0.218290041937438 1.0 0.4488519924029705 30 P04062,Q14108 2 +Intestinal pseudo obstruction 0.5592990949402387 1.2300356865120876 0.2186837415866476 1.0 0.4488519924029705 10 P03886,P00403 2 +Abnormality of the auditory canal 0.4705807097041007 1.2298457558810807 0.2187548702548278 1.0 0.4488519924029705 21 P55011,Q9Y619,P16435,O95202,Q15427 5 +Anteriorly placed anus 0.5538830472842525 1.2296690440478713 0.2188210634298653 1.0 0.4488519924029705 11 P49748,P48651,P16435 3 +Abnormal rectum morphology 0.4336078164932844 1.2283864123433252 0.2193019461279257 1.0 0.4496367350884126 28 Q9Y4P3,Q8TAA9,P28340,P51812,P21912 5 +Paraparesis 0.4393267676328925 1.2278454080002286 0.2195050061510728 1.0 0.4498492509651707 27 Q13510,P04062,Q9Y619,Q6DKK2,P21912 5 +Acanthocytosis 0.5776994630896836 1.22759444830777 0.2195992469197174 1.0 0.4498492509651707 6 Q9Y6B6,Q96RL7 2 +Delayed puberty 0.3809915796737592 1.227026898487882 0.2198124811946262 1.0 0.4500876102380932 58 P04062,Q15800,Q13315,P06280,Q9P2D1,O75844,Q14108,P16435,Q9NVI7 9 +Undetectable visual evoked potentials 0.5320673188661393 1.2258950568514626 0.2202381692276787 1.0 0.4505621022597073 4 Q8TC12,P14854 2 +Elevated circulating follicle stimulating hormone level 0.5314128049371224 1.222430186032289 0.2215449898549781 1.0 0.4528352121858948 4 P16435 1 +Hypertriglyceridemia 0.4647628147846809 1.222174391402845 0.2216416858611116 1.0 0.4528352121858948 22 O95470,O75431,P06737,P22830,P50402,Q9Y285,Q9UJS0,P28340,Q13426,P35573,Q9BTV4 11 +Abnormal auditory evoked potentials 0.5628088676155331 1.221758622674327 0.2217989201129622 1.0 0.4529572671845373 9 P07602 1 +Abnormal cornea morphology 0.3206618069139627 1.2202220419180472 0.2223807132434476 1.0 0.4535589924212094 162 P42858,P01889,P55011,Q9Y4P3,P06280,Q9H9S5,Q9BPU6,P10412,Q8NAT1,O95202,Q2TAA5,Q13510,P16278,Q9UL01,Q92974,O75381,Q7LGA3,Q9UBM7,Q14739,P12235,O15360,Q9NWM8,P21964,Q16625,P04062,P51648,O75844,Q06136,O75845,P49327,Q96L58,P10619,O43505,Q9NVI7,Q9NZ08 35 +Abnormal conjunctiva morphology 0.4383138073483035 1.2201107190917395 0.2224229056377469 1.0 0.4535589924212094 27 Q13510,P49327,P01889,Q13315,P06280,P10619,Q14739,Q9NZ08,P21912 9 +Vomiting 0.3586587287875709 1.2190471077987624 0.2228263132857801 1.0 0.4538584180296952 100 Q13277,Q13423,Q9P032,Q96CU9,Q9Y619,P06280,O43676,Q2TAA5,Q9Y6B6,P11117,Q86Y39,Q9Y584,P23786,P03886,P07602,P00403,Q9NSD9,Q16836,P49748,P22695,Q9NZJ7,Q9NPL8,P51571 23 +Abnormality of prenatal development or birth 0.3153970025107178 1.218742012812272 0.2229421266346727 1.0 0.4538953200458762 258 Q9UHX1,Q96CU9,Q9Y619,Q9Y4P3,O43772,O43676,O95202,Q13510,P16278,Q7LGA3,P0DP25,Q6PGP7,P16435,Q14739,O15360,Q86Y39,P23786,P42766,P04062,P03886,Q9P2D1,O75844,P51798,Q15427,Q9NSD9,Q9Y487,Q70HW3,O15118,Q96L58,P62847,Q8TAA9,P10619,Q9BT22,Q9NPL8,Q9NVI7,Q7KZN9 36 +Functional abnormality of male internal genitalia 0.4188137182398622 1.217687619025527 0.2233427037405251 1.0 0.4545116958293823 34 P04062,Q13423,Q9Y4P3,Q13315,P16435,O15360 6 +Short ribs 0.5564063357228456 1.214700720498619 0.2244802576495432 1.0 0.4560785563197917 10 Q96HY6,Q9Y619,Q15427 3 +Abnormal periventricular white matter morphology 0.3967382893953352 1.2141930461849035 0.2246740153018962 1.0 0.4560785563197917 44 P15289,Q9UHX1,P17900,P07602,Q9H9S5,Q9NZJ7,O75503,O95202,P51571 9 +Vitiligo 0.566107426624345 1.2139534143162647 0.2247655140791966 1.0 0.4560785563197917 8 P49327,P03886,P00403 3 +Ulnar bowing 0.5010594056401032 1.2138636256678723 0.2247998049875856 1.0 0.4560785563197917 3 P16435 1 +Large fleshy ears 0.4725787631272085 1.2122609892035994 0.2254124918388822 1.0 0.4571219716645337 2 P21281 1 +Abnormality of chromosome stability 0.4858662383838688 1.2105003806915025 0.2260869447765676 1.0 0.4578901244254286 18 P13073,O15360,Q13426 3 +Abnormality of the anterior fontanelle 0.4202705165054143 1.2091312584720193 0.2266124218822751 1.0 0.4585545784255446 33 P42345,Q13535,Q96MG7,Q9Y619,P51812,Q9BPU6,P16435,Q16134,Q9Y487 9 +Nephrotic syndrome 0.4266019486706687 1.205162376765977 0.228140623447826 1.0 0.4610445135009133 30 O95470,Q9BT22,Q14108,Q9P2D1 4 +Urticaria 0.5383712788447562 1.2046070178490025 0.2283550462309747 1.0 0.461217035254264 12 Q15427,P21912,P51648 3 +Premature skin wrinkling 0.4668677601870443 1.204427115619107 0.2284245368316964 1.0 0.461217035254264 21 O75844 1 +Postaxial foot polydactyly 0.5588711017203383 1.2012347013509257 0.2296601720619391 1.0 0.4626827723631588 9 Q14739,Q9UBM7 2 +Abnormality of the 5th toe 0.5588711017203383 1.2012347013509257 0.2296601720619391 1.0 0.4626827723631588 9 Q14739,Q9UBM7 2 +Hypoplasia of the frontal lobes 0.5538585172609739 1.201190699405368 0.229677236327126 1.0 0.4626827723631588 10 Q86XL3,P42695,Q9UBM7 3 +Skin nodule 0.4660156846253667 1.1985910396249355 0.2306870040273236 1.0 0.4640408926022162 21 Q13510,P49327,P01889,P11802,P06280,P16615,Q9NZ08,P21912 8 +Abnormal talus morphology 0.483966397158007 1.1982443858184235 0.2308218904011454 1.0 0.4640408926022162 18 O75844,Q9UHX1 2 +Hypoplasia of the iris 0.5699038803057236 1.1889025508848532 0.2344780162363509 1.0 0.4705273302891259 6 O95202 1 +Difficulty standing 0.5472135693795845 1.188427974932488 0.2346648403809261 1.0 0.4705450359990432 5 O43292 1 +Abnormality of the uterus 0.3750373992283652 1.1878143180611818 0.2349065721344505 1.0 0.4706886292080092 61 P21964,Q16740,O15360,Q9UBM7,Q9P2D1,Q07812,P28340,P51812,O95202,Q15427,Q07864,P21912 12 +Moderately reduced visual acuity 0.4963524948935084 1.187731847028448 0.2349390725642215 1.0 0.4706886292080092 3 O60313,O00429 2 +Abnormal pharynx morphology 0.3959523296314185 1.1849832763792556 0.2360240591853155 1.0 0.4720481183706311 42 Q13510,Q03519,Q13277,P16278,Q03518,P54802,Q13432 7 +Abnormal chorioretinal morphology 0.4279657626427988 1.184408812514226 0.2362512734549193 1.0 0.4722992325609103 28 Q5XKP0,Q01968,Q9Y619,O75381,Q9P2D1,Q9H9S5,O43505,Q8NAT1,P53701 9 +Sensory neuropathy 0.4145841846383374 1.1824113295069805 0.237042529953467 1.0 0.4728006708785993 34 Q15067,Q96RL7,Q15041,P03886,Q8IV08,Q13426,P00403 7 +Insulin resistance 0.4878786821309979 1.182368271089162 0.2370596071421036 1.0 0.4728006708785993 17 O75844,Q13426 2 +Poor motor coordination 0.4999000434247724 1.1821952725450304 0.2371282280132725 1.0 0.4728006708785993 15 O75503,P42858,Q96RL7,Q9H9S5 4 +Chordee 0.5684766510061525 1.1818171934545054 0.2372782441235563 1.0 0.4728006708785993 6 P53701,P48651,P16435 3 +Cyanosis 0.4669003132788891 1.1745054824358947 0.240192617275645 1.0 0.4754087121504912 20 O75844,P51812 2 +Cachexia 0.4735987792296294 1.1737731037684696 0.240485919864164 1.0 0.4754087121504912 19 Q99720,Q13535,P04062,P07602 4 +Desquamation of skin soon after birth 0.5221842212947343 1.1735645267151351 0.2405694968286278 1.0 0.4754087121504912 4 P04062 1 +Recurrent aspiration pneumonia 0.562425325745088 1.1724501463240429 0.241016376509209 1.0 0.4760893219650447 7 P04062 1 +Weight loss 0.3627092987564831 1.1707248096014895 0.241709409494728 1.0 0.477255383133237 78 P42858,Q13423,P01889,Q5HYI8,Q99720,P21912,P42892,Q96RL7,O95613,O15360,P04062,Q13315,P07602,O75844,Q06136,P49327,Q13535,Q9NZJ7,Q9NZ08 19 +Bifid scrotum 0.5616550670076215 1.1685644802811106 0.2425791460653463 1.0 0.4787692067203055 7 P16435,Q9P2D1,Q9UBM7 3 +External ophthalmoplegia 0.4972122076312717 1.1658606185357163 0.2436708036022126 1.0 0.4803861456652316 15 P12235,P03886,P00403 3 +Hydrocele testis 0.5652024453791406 1.1655618069319331 0.2437916572897545 1.0 0.4803861456652316 6 Q9UBX3 1 +Delayed cranial suture closure 0.4255440523668637 1.1655115305867625 0.2438119955829996 1.0 0.4803861456652316 28 O75844,P51812 2 +Motor deterioration 0.5424297370880506 1.1639102146322349 0.2444603996218726 1.0 0.4812555155267881 5 O75503 1 +Abnormal cortical bone morphology 0.4720625353101123 1.1636413891721171 0.2445693708528864 1.0 0.4812661147744644 19 Q86XL3,P51798,P48651,P42695,Q9NSD9 5 +Neonatal hypoglycemia 0.555728458863647 1.160739861670062 0.2457477060220063 1.0 0.4827783492625314 8 O43772,P42345 2 +Abnormal left ventricle morphology 0.4230307443604033 1.160725600217542 0.2457535075346291 1.0 0.4827783492625314 29 P10253,P03886,P06280,P00403,P12235,P21912 6 +Functional abnormality of the inner ear 0.3119720107456499 1.158887164897047 0.2465021813483705 1.0 0.4838399385485972 263 P15289,Q9P032,Q16740,Q96CU9,P55011,Q9Y4P3,P06280,P51812,Q13426,O43676,O95202,Q9H061,Q2TAA5,P42167,P21912,Q13510,Q15043,P42892,O95613,Q9NR77,Q15904,Q7LGA3,P0DP25,Q9UBM7,P48651,O43681,P12235,Q86Y39,O95470,Q9NWM8,P04062,O15269,P03886,P07602,Q9P2D1,O76024,O75844,Q9Y6M9,P00403,Q96SN8,Q15067,P49327,Q5XKP0,Q96L58,P28340,Q9NZJ7,Q9NPL8,Q9NZ08 48 +Vertebral fusion 0.5299481488837456 1.1578415562488518 0.2469287012806242 1.0 0.4840636059703715 12 O95202,Q9UHX1,Q8TAA9 3 +Long clavicles 0.5183601282790312 1.1533139431117752 0.248781549188999 1.0 0.4860527644143413 4 Q14739 1 +Inability to walk 0.3564520292920421 1.152475415673485 0.2491257664015387 1.0 0.4861143682072864 94 P42858,Q96CU9,Q9H9S5,Q99720,P21912,Q13510,Q15043,Q96RL7,Q15041,Q9NR77,O43292,P12235,Q96N66,P27635,Q96N67,Q9Y5P6,O15269,Q13409,Q8WVX9,O14949,Q8TB36,O75190,P11166,Q9BUK6,O75503,Q9NVI7 26 +Coxa vara 0.5178451751161729 1.1514784976125738 0.2495354363318775 1.0 0.4865050932429304 13 O95613,Q96AY3,P26373,Q99575,Q96HY6,Q9Y487 6 +Joint dislocation 0.3558296289350131 1.1504037166407 0.2499776300753358 1.0 0.4871627807592324 95 Q9UHX1,P55011,Q9Y619,Q9Y4P3,Q9H9S5,Q9BPU6,O95202,Q9UL01,Q9UBM7,P43034,O15360,Q96A33,P21964,O75844,P51798,Q6ZXV5,Q15427,Q9Y487,Q13535,Q96L58,P51571 21 +Abnormal shape of the palpebral fissure 0.4942183832281069 1.1476619198610702 0.2511081571971505 1.0 0.4887509419094937 15 Q9UHX1 1 +Retinal pigment epithelial mottling 0.4609101516919703 1.1441968046035955 0.25254202800769 1.0 0.4913359556632025 2 O60231 1 +Rhabdomyolysis 0.5164290784278693 1.14338182970169 0.2528800932739981 1.0 0.491581972113387 13 O43772,P23786 2 +Abnormal sensory nerve conduction velocity 0.5606774041694568 1.1430961381573206 0.2529986775234529 1.0 0.491606798734405 6 Q9NR77 1 +Status epilepticus 0.3753945921185919 1.14191998079095 0.2534872824620493 1.0 0.4923502986282111 53 Q13510,P42892,Q15392,P07602,O43292,Q9Y487 6 +Abnormal circulating proteinogenic amino acid derivative concentration 0.4436491421313536 1.1414055745992262 0.2537011859476346 1.0 0.4925598453458881 24 Q5XKP0,P03886,P22695,Q99797,Q9P0J0 5 +Abnormality of blood circulation 0.3615844467395247 1.1379040542882688 0.2551605481618588 1.0 0.4951862601336659 70 P05067,P21964,P49327,Q13277,P04062,Q9UHX1,O76024,P38435,O75844,P50570,Q9Y487,Q14739,Q9NZ08,P23786,P21912 15 +Hypoplasia of teeth 0.4381005561307823 1.1375929292049398 0.2552905005140711 1.0 0.4952315930640394 25 O75844,P55011,Q13535,P51648 4 +Temperature instability 0.5507447406139209 1.135182746514102 0.2562987570213859 1.0 0.4967535178214947 8 Q9NZJ7,P07602 2 +Abnormal atrioventricular conduction 0.4741606056460827 1.1349351213551702 0.2564025030005363 1.0 0.4967535178214947 18 P49748,Q99959,P06280,P0DP25,O43772,Q9BTV4,P21912 7 +Radioulnar synostosis 0.45195969206516 1.13291208123404 0.2572511760392846 1.0 0.4967535178214947 22 Q15427,Q96L58,O95202,Q9Y4P3 4 +Lethargy 0.3584342455705944 1.1287361764261832 0.2590091435178749 1.0 0.4984906714101272 82 Q9NWS8,P42766,O14678,Q16836,Q9P032,Q96CU9,P49748,Q96IX5,P03886,Q9Y619,P62847,Q9NPL8,P49770,O43772,O43676,P12235,Q86Y39,P23786 18 +Joint stiffness 0.3726104047699453 1.1277322072043323 0.2594330314491571 1.0 0.4986484566805079 56 P16278,Q9Y4P3,Q96AY3,P51648,O76024,O75844,Q8TAA9,P16435,Q15427,P54802,Q9BTV4 11 +Abnormality of female external genitalia 0.3943848847964956 1.1252121395268988 0.2604991501776599 1.0 0.5002820160477964 39 Q15392,Q13535,O95613,Q9Y619,Q9P2D1,P16435,P31939 7 +Unusual infection by anatomical site 0.5238003961349047 1.1236963227140275 0.2611418769687903 1.0 0.5009899152698696 12 P49327,P01889,Q8TAA9,Q14739,Q9NZ08 5 +Hypertonia 0.2814667271539988 1.1226134329588568 0.2616017078012707 1.0 0.5009899152698696 393 P15289,Q15392,P42858,Q6PJG6,Q9P032,Q96CU9,Q15165,P55011,Q9Y619,Q9Y4P3,Q86XL3,P51812,Q9H9S5,Q9P0J0,P10412,Q99720,Q6DKK2,Q2TAA5,P21912,Q13510,Q15043,Q96RL7,P49902,P16278,Q9Y287,Q15041,Q7LGA3,Q9UBM7,O43292,Q9UBX3,P49770,P50897,P42695,Q14739,O43681,P12235,P11117,Q96N66,Q16625,P04062,P03886,Q13315,P07602,Q13409,P51648,Q6ZXV5,Q9Y487,P05067,O15118,Q15067,Q5XKP0,P17900,Q15907,Q96KP1,Q9NZJ7,O75503,Q99797,O43505,Q9NVI7,Q7KZN9 60 +Localized skin lesion 0.3106363760833973 1.1212465289839055 0.2621829391194132 1.0 0.5010703147465216 230 Q15392,P42858,Q9UHX1,P55011,Q9Y619,Q9Y4P3,P06280,P38435,P10412,O95202,P21912,Q13510,O95613,Q7LGA3,Q6PGP7,P48651,Q14739,O15360,Q9NWM8,P21964,P04062,Q03519,O15269,Q13315,P07602,Q9P2D1,O75844,Q13126,Q03518,Q06136,Q6ZXV5,Q15427,P42345,Q96L58,Q96AY3,Q8IZA0,Q8TAA9,P28340,Q9NZJ7,Q03164,P16615,Q9NZ08 42 +Abnormal circulating carbohydrate concentration 0.3899682657993276 1.1208155985906123 0.2623663630258981 1.0 0.5010741948818827 41 Q70HW3,Q96CU9,P03886,P22695,Q9NPL8,O43676,Q86Y39,P21912 8 +Abnormal larynx physiology 0.5013092392943082 1.1207350202781816 0.2624006707162334 1.0 0.5010741948818827 14 Q15165 1 +Type i diabetes mellitus 0.5231448794094439 1.1200553529481785 0.2626901748057515 1.0 0.5011381982914412 12 P03886,P00403,P50851 3 +Fibular hypoplasia 0.5520075111285991 1.1198967084645528 0.2627577811101917 1.0 0.5011381982914412 7 Q15427 1 +Prominent superficial blood vessels 0.5230433381620477 1.1194913582685506 0.2629305755467288 1.0 0.5012619835823152 12 O75844 1 +Abnormal number of granulocyte precursors 0.4565344224037377 1.118680739920902 0.2632763647015617 1.0 0.5016863294922324 2 Q07020 1 +Hyperostosis 0.4894114302888294 1.1184351696012207 0.2633811806604407 1.0 0.5016863294922324 15 Q96L58,P51812,Q15043 3 +Vertebral compression fracture 0.4777362057042322 1.1182104831719295 0.2634771080415512 1.0 0.5016863294922324 17 Q96HY6,P04062,Q14108 3 +Global brain atrophy 0.458391407306381 1.1171226797985392 0.2639418745067512 1.0 0.5021596842581352 20 P07602,Q9UHX1 2 +Symptomatic seizures 0.5509211478723073 1.1144173080578286 0.2651002014949082 1.0 0.5041538548661217 7 Q16836,Q13423 2 +Abnormality of the vasculature of the eye 0.358175110757051 1.1141681313240757 0.2652070644194579 1.0 0.5041538548661217 75 Q13510,P49327,P21964,P16278,P17900,P03886,Q9Y4P3,Q13315,P07602,P06280,P38435,P10619,Q9NZJ7,Q14739,Q9NZ08,P21912 16 +Paroxysmal involuntary eye movements 0.4536157707156616 1.113570475650363 0.2654634983446822 1.0 0.5044071028321099 21 Q9P032,Q96CU9,P03886,Q9NPL8,O43676,Q86Y39 6 +Abnormal acetabulum morphology 0.4445174319991736 1.1130988254645229 0.2656659880822585 1.0 0.5044071028321099 23 Q9Y584,Q96L58,Q96AY3,P16278 4 +Neck muscle weakness 0.4883880159299167 1.1122121421543842 0.2660469484797341 1.0 0.5049240697045934 15 Q99720,P07602 2 +Aplasia hypoplasia involving the femoral head and neck 0.5320623110137508 1.1118617829566293 0.2661975826905529 1.0 0.5050036623847729 11 O75431,O95831,Q96L58,Q99575,Q96HY6 5 +Pectus carinatum 0.3897724424982143 1.110450539820674 0.2668049300667057 1.0 0.5059492673836385 40 P16278,Q96L58,Q9Y619,Q96AY3,P51812,Q9NVI7 6 +Upper motor neuron dysfunction 0.2809989273417426 1.1096770760936192 0.2671382046079948 1.0 0.5063745812357178 396 P15289,Q15392,P42858,Q6PJG6,Q13423,Q9P032,Q96CU9,Q15165,P55011,Q9Y619,Q9Y4P3,Q86XL3,P51812,Q9H9S5,Q9P0J0,Q99720,Q6DKK2,Q2TAA5,P21912,Q13510,Q15043,P49902,P16278,Q9Y287,Q15041,Q9NR77,O43292,Q9UBX3,P49770,P50897,O43681,P11117,Q96N66,Q16625,P04062,P03886,Q13315,P07602,Q13409,P51648,Q9P2D1,P00403,Q6ZXV5,Q01105,Q9Y487,Q15067,O15118,P42345,Q5XKP0,P17900,Q96L58,O14773,Q15907,Q96KP1,Q9NZJ7,O75503,O43505,Q9NVI7,Q9NZ08,Q7KZN9 60 +Ankyloblepharon 0.509876286198463 1.1083987385319125 0.2676896494702609 1.0 0.5070061603908815 4 O75569 1 +Gastrointestinal obstruction 0.4991290163450282 1.107886370256685 0.2679108926247946 1.0 0.5072184218153203 14 Q5HYI8,P42892 2 +Abnormality of the elbow 0.364989181270538 1.1069605693564983 0.2683109766090195 1.0 0.5072258338482007 64 Q13510,Q13535,O95613,Q9Y619,Q96L58,Q96AY3,P37268,Q7LGA3,Q03164,P16435,Q15427,P23786 12 +Premature birth 0.3884003633515864 1.1065462559955472 0.2684901546024982 1.0 0.5072258338482007 41 O75844,O43676,P04062 3 +Gastrointestinal hemorrhage 0.4161145546069841 1.1061097230164425 0.2686790308007796 1.0 0.5072258338482007 29 P49327,P21964,Q9UHX1,O76024,Q14739,Q9NZ08,P21912 7 +Low set posteriorly rotated ears 0.3575700652409471 1.105734391742766 0.2688414995844199 1.0 0.5073264041710865 71 Q15392,P04062,Q9UM00,Q9UL01,Q96L58,Q9Y4P3,P37268,O75381,Q9UBM7,Q9P2D1,P16435,O95202,Q15427 13 +Fibrous tissue neoplasm 0.4629971318246719 1.103821138246163 0.2696707334319583 1.0 0.5082718975760155 19 Q15392,Q13126 2 +Convex nasal ridge 0.4384159035636922 1.1035469297339435 0.2697897232866846 1.0 0.5082899652838349 24 O75844,O95202,Q13426,Q13535 4 +Abnormal tracheobronchial morphology 0.3583805975163303 1.101523820633895 0.2706687429986694 1.0 0.5093264398427776 70 Q13277,Q03519,O95613,P55011,Q9Y4P3,Q13315,Q96L58,Q9P2D1,Q03518,P16435,Q14739,Q96HY6,O15360,Q13432 14 +Spastic paraparesis 0.455486814944026 1.0975245063932648 0.2724121739800673 1.0 0.5111077221444342 20 Q6DKK2,Q9Y619,P04062,P21912 4 +Abnormality of fibula morphology 0.5080036830976651 1.095204808542807 0.2734269195407126 1.0 0.5122344629782867 13 Q96HY6,Q15427,Q13535 3 +Aplasia hypoplasia of the ear 0.3698096483334061 1.0938137506825156 0.274036672060133 1.0 0.5129630855726744 55 P42766,P04062,Q9Y619,P62847,Q9P2D1,Q6PGP7,Q9H9S5,O95202,Q15427,Q07864 10 +Abnormality of the ureter 0.356459145754023 1.0931899920800114 0.2743103902075059 1.0 0.5132686560225825 73 P21964,Q9UHX1,Q9Y4P3,Q86XL3,Q7LGA3,Q9UBM7,O76024,Q9P2D1,O75844,Q8TAA9,P42695,P16435,O15360,P23786,P21912 15 +Abnormality of earlobe 0.4083780858875871 1.0926516380309277 0.2745467811861102 1.0 0.5134798601669676 32 Q15392,Q13535,O95613,Q9P2D1,Q7LGA3,P16435 6 +Papule 0.4610614209009897 1.0910434535138296 0.2752537625662046 1.0 0.5139987865283707 19 P49327,O75844,P38435,P16615,Q9NZ08,P21912 6 +Sound sensitivity 0.5376228993608023 1.090437432641204 0.2755205002511074 1.0 0.5142901744341684 9 P17900 1 +Pancytopenia 0.3958129148759529 1.0885760247210237 0.2763408941957066 1.0 0.5156143752743987 37 P04062,Q13535,P00374,Q13426,Q14108,O15360 6 +Hypolipoproteinemia 0.5415518760340002 1.088050401740372 0.2765728576914488 1.0 0.5156330244119065 8 P37268,Q15800 2 +Abnormality of skull ossification 0.5066170767445038 1.0872766498727828 0.2769145647844613 1.0 0.5160630036055384 13 Q14739,O75844,P54802 3 +Lower extremity joint dislocation 0.3551050144493116 1.08494465081516 0.2779461703396633 1.0 0.5173629436691008 80 P21964,Q13535,Q9UHX1,P55011,Q96L58,Q9Y4P3,O15360,Q9UBM7,O75844,Q9H9S5,Q9BPU6,Q6ZXV5,P43034,O95202,Q15427,Q9Y487,Q96A33 17 +Delirium 0.4775455792480729 1.0833509069416531 0.2786526974877252 1.0 0.518470337416088 3 P26358 1 +Abnormal middle phalanx morphology of the hand 0.5314944245513787 1.082547389812386 0.2790093698923119 1.0 0.5186555304642542 10 O95613,Q03164,Q9UHX1 3 +Abnormality of the lower urinary tract 0.3084344370286198 1.0823722936346376 0.279087134343658 1.0 0.5186555304642542 227 P15289,P01889,Q9UHX1,O75165,Q9Y619,Q9Y4P3,Q86XL3,P51812,Q99720,O95202,P21912,Q9UL01,O95613,Q9NR77,O75381,Q15555,Q9UBM7,Q9UBX3,Q6PGP7,P48449,P48651,P16435,O43681,P42695,P12235,O15360,Q9NWM8,P27635,P21964,Q9H5V9,P04062,P42766,P07602,Q9P2D1,O76024,O75844,Q96SN8,P42345,Q13535,P62847,Q8TAA9,P51970,P50570,Q9NZJ7,P37268,Q07864,P51571 47 +Dermal translucency 0.5359213108687086 1.081567357881145 0.2794448154285098 1.0 0.5191125999523617 9 O75844 1 +Genu valgum 0.394940541158346 1.0809978530420812 0.2796980686574595 1.0 0.5191841063804088 37 P16278,Q9Y619,Q9NR77,Q9Y4P3,Q96L58,Q7LGA3 6 +Intestinal polyp 0.4657455451096852 1.0805658709886867 0.2798902708638913 1.0 0.5193171718984181 18 P42892,P28340,P42345,P21912 4 +Female hypogonadism 0.5439120537467101 1.079075016993049 0.2805542873338245 1.0 0.5197564830883569 7 O75844,Q13315 2 +Hand polydactyly 0.3965268441166289 1.0722490618857128 0.2836081792475071 1.0 0.5237057236820024 36 Q15067,P21964,Q9UHX1,Q9UBM7,Q9P2D1,Q14739,O95202,O75845 8 +Large for gestational age 0.5378912079814805 1.0692908306428897 0.2849386410455072 1.0 0.5248402635313575 8 P50570,P42345,Q9UM00 3 +Peripheral axonal degeneration 0.3541170636216781 1.0670552951842245 0.2859468673055008 1.0 0.5259339451707666 75 Q15067,Q96RL7,O15269,P03886,P07602,Q8IV08,O76024,Q9NZJ7,Q13426,Q9BQT8,P00403,Q6DKK2,Q9NVI7,P12235,Q8TB36 15 +Bowing of the legs 0.3675686352187485 1.0664472921549666 0.2862214930804354 1.0 0.5262307308475279 54 P16278,Q9Y619,Q9Y4P3,Q9NR77,Q96L58,Q7LGA3,Q13126,P16435,Q96HY6 9 +Spasticity 0.2960894371298814 1.0628401332069015 0.2878544559395068 1.0 0.5279798572145976 328 P15289,Q15392,P42858,Q9P032,Q96CU9,Q15165,P55011,Q9Y619,Q9Y4P3,Q86XL3,P51812,Q9P0J0,Q99720,Q6DKK2,Q2TAA5,P21912,Q13510,Q15043,P49902,P16278,Q9Y287,Q15041,O43292,Q9UBX3,P49770,P50897,O43681,P11117,Q96N66,Q16625,P04062,P03886,Q13315,P07602,Q13409,P51648,Q6ZXV5,Q9Y487,O15118,Q5XKP0,P17900,Q15907,Q96KP1,Q9NZJ7,O75503,O43505,Q9NVI7,Q7KZN9 48 +Skeletal dysplasia 0.3767771640746744 1.062661008662312 0.2879357091718615 1.0 0.5279798572145976 47 P16278,Q96L58,P51648,Q9P2D1,P10619,Q14739,Q96HY6,Q15427,Q07864 9 +Abnormal full field electroretinogram 0.5443740282230298 1.0621978058244934 0.2881458957447496 1.0 0.5279798572145976 6 Q15067,P50897 2 +Abnormal light and dark adapted electroretinogram 0.5443740282230298 1.0621978058244934 0.2881458957447496 1.0 0.5279798572145976 6 Q15067,P50897 2 +Thickened skin 0.343455826483641 1.0619739049963637 0.2882475318346624 1.0 0.5279798572145976 105 P06280,Q13426,P42167,P21912,P16278,Q9UBN7,Q14691,P48449,Q14739,O95470,Q9NWM8,P04062,P51648,Q9P2D1,O75844,Q06136,Q15800,P28340,P16615 19 +Flared metaphysis 0.5273491610820888 1.06056595091669 0.2888872032622405 1.0 0.5284133647072321 10 Q14739,O95613,Q96L58,Q96HY6 4 +Talipes valgus 0.50058377116171 1.059246294784021 0.2894876264009083 1.0 0.5292045844338844 4 Q15233,Q9H2M9,O00754 3 +Abnormal circulating metabolite concentration 0.2847645586375115 1.0560253286826708 0.2909566431363353 1.0 0.5311530703384729 362 Q15392,P42858,Q13423,Q9P032,Q96CU9,Q9Y619,Q9Y4P3,P14854,P06280,Q9H9S5,Q13426,Q9P0J0,O43772,O43676,P42167,P21912,Q8N511,Q15043,Q96RL7,Q9Y6B6,Q15904,Q9UBM7,P0DP25,Q6PGP7,Q14739,P12235,Q86Y39,Q9Y584,P23786,O95470,P47985,Q9NWM8,P21964,P13473,P03886,Q13315,P07602,Q9P2D1,O75844,P51798,Q9Y6M9,Q6ZXV5,Q9NSD9,Q9Y487,O75845,P10253,P22830,Q70HW3,P05067,O14678,Q16836,Q15800,Q5XKP0,P49748,P22695,P28340,Q9NZJ7,Q9BT22,Q99797,O43505,Q9NPL8,Q9NVI7,P37268 63 +Abnormality of the liver 0.299832937269333 1.049511984185498 0.2939425424789843 1.0 0.5359721555562642 310 P15289,Q9P032,Q96CU9,Q5HYI8,Q9Y619,Q9Y4P3,P09601,Q13426,Q14108,O43772,O43676,O95202,Q96HY6,P21912,Q8N511,Q13510,Q96RL7,P16278,Q9Y6B6,Q15904,Q9UBM7,Q6PGP7,P00374,Q14739,O43681,P12235,O15360,Q86Y39,Q96A33,P23786,P47985,Q9NWS8,Q16625,P04062,P21964,P03886,P07602,Q9P2D1,P51798,Q9Y6M9,Q9NSD9,O75845,P10253,P22830,Q15067,O15118,P49327,Q16836,Q5XKP0,P49748,P10619,P28340,Q9NZJ7,Q9BT22,Q9NPL8,Q9NVI7,P54802,Q7KZN9 58 +Hydrocephalus 0.3497752673468993 1.0465814816722034 0.2952926464700895 1.0 0.5380116217647201 89 Q15392,P04062,Q96L58,O15360,Q9UBN7,Q8TAA9,Q9UBM7,P51798,Q9H9S5,P48651,O43505,P16435,O95202,Q15427,P23786 15 +Delayed ability to stand 0.497941372391613 1.0452829228803486 0.2958922279479368 1.0 0.5387364847970844 4 P21912 1 +Nevus 0.4065160615894954 1.0447942144642048 0.2961180894229409 1.0 0.5388815681390456 30 Q9Y4P3,P10412,Q9UHX1,P21912 4 +Recurrent respiratory infections 0.3229631283753317 1.044471176668769 0.2962674478911582 1.0 0.5389422720839159 136 Q13546,Q13277,Q9Y4P3,P09601,O95202,Q13510,P16278,O95613,P04062,Q03519,Q13315,P07602,Q8N5M9,P51798,Q03518,Q9Y487,P10253,Q9UJW0,P78527,O00203,Q9NZJ7,Q9NPL8,P54802,Q13432,Q07864 25 +Thoracic hypoplasia 0.404497948983867 1.0441975962033043 0.2963939788835539 1.0 0.5389614191362001 31 P42345,P04062,Q9UHX1,P51798,P16435,Q14739,Q96HY6,Q96A33 8 +Tip toe gait 0.4700904581266575 1.0420392599642574 0.2973934773115272 1.0 0.540489460930122 3 Q9ULH0,Q9UDR5 2 +Abnormal endocardium morphology 0.4656236376597801 1.041563139287296 0.2976142657880807 1.0 0.5405456914978197 17 P49327,P04062,Q9Y4P3,P06280,Q9NZ08 5 +Stroke 0.395202339118995 1.0399002678437896 0.2983862380272621 1.0 0.541242564680566 35 P05067,O95613,P03886,Q9Y4P3,Q96L58,P06280,O76024,O75844,P00403 9 +Abnormal peripheral nervous system morphology 0.3063467274633608 1.0391607907725482 0.2987299623897761 1.0 0.541242564680566 167 P15289,Q9P032,Q9UHX1,Q9Y619,Q8IV08,P51812,Q9H9S5,Q13426,Q9BQT8,Q6DKK2,Q99720,P21912,Q13510,Q15043,Q96RL7,Q9NR77,P48651,O43681,P12235,O15269,P03886,P07602,Q9P2D1,P51798,P00403,Q8TB36,Q15067,Q9NZJ7,Q9NVI7 29 +Increased serum lactate 0.340433793016258 1.0390303473210565 0.2987906226418368 1.0 0.541242564680566 107 Q96CU9,Q9P0J0,P21912,Q9UBX3,P13073,P12235,Q86Y39,Q9Y584,Q9NWS8,P03886,O14949,P00403,Q70HW3,Q5XKP0,P22695,Q99797,Q6P4A7,Q9NVI7,Q7KZN9 19 +2 3 toe syndactyly 0.4091076169799176 1.0370287521388544 0.2997224576041792 1.0 0.5422548824100533 28 P51812,Q9UHX1 2 +Generalized joint laxity 0.4757409697023347 1.0353239946700594 0.3005176277013173 1.0 0.5434818599845543 15 Q9P2D1,Q9Y487,Q9UHX1,Q9BUK6 4 +Multiple cafe au lait spots 0.464557348774118 1.034817801627349 0.3007540077463007 1.0 0.5435783160155174 17 O15360,Q13315,P21912 3 +Immunodeficiency 0.3556200208778913 1.0345157426514648 0.3008951210677253 1.0 0.5435783160155174 67 P21964,Q07864,Q9UJW0,Q13315,Q9P2D1,P09601,Q6PGP7,Q9BT22,Q13426,O95202,Q13432,Q96A33,P21912 13 +Hyperventilation 0.5350555559861687 1.0344583022628997 0.3009219605664897 1.0 0.5435783160155174 7 P03886 1 +Abnormality of the endometrium 0.5340506812473388 1.0294000364867852 0.3032917319877652 1.0 0.5470083023350766 7 P28340,P21912 2 +Abnormal enchondral ossification 0.4041695988653297 1.026029333342229 0.3048777576570476 1.0 0.5492291826578686 30 Q9Y619,Q96L58,O00116,P38435,Q14739,Q96HY6,O95202 7 +Abnormal large intestine physiology 0.4408058641926685 1.0256576055936548 0.3050530040535029 1.0 0.5493318824932459 21 P15289,P07602,P06280,Q8TAA9,Q9NZJ7,O43681 6 +Exercise induced myoglobinuria 0.5147083726607917 1.0219786893994756 0.3067909867508884 1.0 0.5505411063903545 5 P49748 1 +Abnormal ldl cholesterol concentration 0.4843342062633037 1.0207300876455756 0.3073823354530569 1.0 0.5511765073388276 14 Q8N511,P37268,Q15800 3 +Anorexia 0.4116346388643881 1.0158109906605404 0.3097194012581883 1.0 0.5538530614397572 27 P49327,P04062,Q13423,Q5HYI8,Q13315,P06280,Q14108,Q9NZ08 8 +Vascular neoplasm 0.3899104147143905 1.0154520468606223 0.3098903939446944 1.0 0.5538530614397572 36 P42345,Q9UHX1,Q7LGA3,Q9UBM7,P10619,P16435,O95202,P21912 8 +Abnormal cardiac test 0.4350401936541201 1.0147752293734285 0.3102129840342877 1.0 0.5538530614397572 22 Q16836,P49748,Q99959,P0DP25,P12235,Q9BTV4,P10253 7 +Psoriasiform dermatitis 0.4921518845626551 1.014717510660623 0.3102405046388965 1.0 0.5538530614397572 4 Q15800 1 +Aplasia hypoplasia involving bones of the upper limbs 0.3135629495445397 1.014092464368341 0.3105386334434377 1.0 0.5538530614397572 153 P42858,Q9UHX1,Q9Y619,P38435,P51812,O95202,Q13510,O95613,O15228,Q9UBN7,Q9UBM7,P13073,P16435,Q14739,O15360,P42766,O00116,Q9P2D1,O75844,P51798,Q15427,P42345,Q13535,Q96L58,Q96AY3,P62847,Q03164 27 +Tetraplegia 0.4822775783861744 1.0086254975970217 0.3131542742647502 1.0 0.5563727564948487 14 P15289,O95831,Q13423,P43034,P51970,Q96T60,O43681 7 +Atrophic scars 0.5257272297567716 1.0070247080410042 0.3139229007903528 1.0 0.5568865204551275 8 Q9NWM8,Q96L58 2 +Abnormal atrioventricular valve physiology 0.3610107929649128 1.003390717377412 0.3156723811054724 1.0 0.5584234474487638 55 P49327,O43819,P04062,P01889,Q9UL01,Q96L58,Q9Y4P3,P14854,Q15904,P06280,Q8WVX9,O75844,P51812,Q9NZ08 14 +Woolly hair 0.5324821894563978 1.0033018036710246 0.3157152661475806 1.0 0.5584234474487638 6 Q6PGP7 1 +Abnormal cd4 cd8 ratio 0.5324169116675914 1.0029789181630868 0.3158710331242684 1.0 0.5584234474487638 6 Q13432 1 +Congenital muscular dystrophy 0.4629290940123918 1.002423735714786 0.3161389831433903 1.0 0.5586845628315676 3 Q9H9S5 1 +Abnormality of bone marrow cell morphology 0.3608568523039329 1.001806673532585 0.3164369734643883 1.0 0.5587860808496953 55 P04062,Q13535,Q13315,P51798,P00374,Q13426,Q14108,Q14739,O15360 9 +Posteriorly rotated ears 0.3340976419121932 1.0006544450378283 0.3169938984186358 1.0 0.5595568586827439 112 Q15392,Q9UHX1,Q9Y619,Q9Y4P3,Q9H9S5,Q8NAT1,O95202,P42892,Q9UM00,Q9UL01,O75381,Q7LGA3,Q9UBM7,P16435,P23786,P04062,Q9P2D1,Q15427,Q96L58,O00203,O43505,P37268,Q07864 23 +Increased csf lactate 0.3646052530550169 0.9998686727005606 0.3173740667597382 1.0 0.5598025490378679 51 Q9NWS8,Q9P032,Q96CU9,P03886,P14854,P13073,Q9Y6M9,Q9NPL8,Q9P0J0,P00403,O43676,Q86Y39,Q7KZN9 13 +Inappropriate crying 0.5281061166833588 0.9994982983385016 0.3175533629970961 1.0 0.559906233200952 7 P07602 1 +Chronic rhinitis 0.4890902247630901 0.998572104577418 0.3180020189931882 1.0 0.56022905578942 4 P51798 1 +Hepatosplenomegaly 0.3713134893809973 0.9983039576543348 0.3181319890961915 1.0 0.56022905578942 46 Q13510,P04062,P11166,P16278,Q5HYI8,Q9Y285,Q9Y5W7,Q96J02,O00203,P10619,P51798,Q14739,Q96HY6,O75845 14 +Aplasia hypoplasia of the cerebral white matter 0.5237404124730902 0.9968683365673614 0.3188284226818472 1.0 0.5605610376826844 8 P03886 1 +Malabsorption 0.3610691695895147 0.9965728805951732 0.3189718749699757 1.0 0.5605610376826844 53 P49327,P42345,Q9UJW0,P01889,Q9Y6B6,Q9Y4P3,P06280,O76024,P09601,Q13426,Q14739,Q9NZ08,Q96A33,Q14566 14 +Abnormal choroid morphology 0.4002019893839941 0.994297454760658 0.3200780744779163 1.0 0.561941351368297 30 Q5XKP0,Q01968,Q9Y619,O75381,Q9P2D1,Q9H9S5,O43505,Q8NAT1,P53701 9 +Abnormality of chorioretinal pigmentation 0.4881254228821834 0.9934873162866448 0.3204725285838101 1.0 0.561941351368297 4 Q9Y619 1 +Skin tags 0.4361019013976481 0.9933860355678342 0.3205218642113618 1.0 0.561941351368297 21 Q15427,Q9UHX1 2 +Breast carcinoma 0.4276266611449671 0.9930464602695672 0.3206873135610486 1.0 0.5620193356486729 23 Q13535,Q5HYI8,Q13315,P28340,P21912 5 +Raynaud phenomenon 0.5226520385826872 0.991306760793908 0.3215358127207164 1.0 0.562657395819378 8 O75844 1 +Abnormal brain lactate level by mrs 0.5096566702025322 0.9909825835218148 0.3216940847519061 1.0 0.5627102174642404 11 P03886,P00403 2 +Oligodactyly 0.522497962942309 0.9905195593195232 0.3219202337645361 1.0 0.5627102174642404 8 Q15427 1 +Clubbing of fingers 0.4875586368397814 0.9905008998374568 0.3219293495522926 1.0 0.5627102174642404 4 P50851 1 +Abnormality of the bladder 0.3231240079537602 0.9890355895233606 0.3226457292811637 1.0 0.5630500222469879 124 P15289,P01889,Q9UHX1,O75165,Q9Y4P3,Q86XL3,P51812,Q99720,P21912,Q9UL01,Q9NR77,P42695,P16435,O43681,P12235,Q9NWM8,P21964,Q9H5V9,P04062,P07602,Q9P2D1,Q8WVX9,O76024,Q96SN8,Q8TAA9,P50570,Q9NZJ7 27 +Laryngomalacia 0.4571309530512466 0.9878630301883166 0.3232197334916207 1.0 0.5636932739497259 17 P21964,O95613,P07602,Q9P2D1,Q9NZJ7,P16435 6 +Abnormality of lipoprotein cholesterol concentration 0.4625740085631294 0.987440033282722 0.323426966900415 1.0 0.56384303497911 16 Q8N511,P37268,Q15800 3 +Diffuse white matter abnormalities 0.5128185260332705 0.983618070538741 0.3253033367362228 1.0 0.5658340066643529 10 O43819,Q9H9S5,P16278 3 +Alkalosis 0.5070244547487153 0.9827587046804512 0.3257262104928178 1.0 0.5658340066643529 5 Q9Y619 1 +Cytochrome c oxidase negative muscle fibers 0.5168288040380801 0.9821856547580132 0.3260083934634346 1.0 0.5660070986663367 9 P12235,Q9Y2R0 2 +Polymicrogyria 0.3459052393011197 0.9815160944065084 0.3263383016462777 1.0 0.5663682291552508 83 Q15392,Q16625,Q9Y5P6,P42345,P55011,P37268,O75381,Q2M389,Q96C86,Q9H9S5,O43505,Q6ZXV5,Q8NAT1,Q01105,Q15427,Q96N66,Q9Y487,P23786 18 +Diminished movement 0.4300883118873734 0.9802117270295936 0.3269816170175663 1.0 0.5666633982569764 22 P42858,P04062,P13473,P12235,Q2TAA5 5 +Abnormality of the female genitalia 0.3161394654199705 0.9801820799756826 0.3269962485421769 1.0 0.5666633982569764 143 Q15392,Q16740,Q5HYI8,Q9Y619,Q9Y4P3,P51812,O95202,P31939,P21912,O95613,Q9UBM7,P49770,P16435,O15360,P21964,Q13315,Q9P2D1,O75844,Q15427,O14965,Q13535,Q07812,P28340,Q07864 24 +Absent thumb 0.4211586653820617 0.9786371708436842 0.3277592862186789 1.0 0.5673508359806193 24 Q15427,P42766,P62847 3 +Abnormality of the peripheral nervous system 0.3363737127594959 0.9769492337546968 0.3285942858420634 1.0 0.56847510895393 106 P15289,Q6PJG6,Q9Y619,P06280,Q99720,P42892,Q96RL7,Q9NR77,Q9UBM7,P0DP25,O43681,O15360,P21964,P04062,O15269,P07602,O76024,Q15427,Q8TB36,Q15067,P50570,Q9NZJ7 22 +Progressive hearing impairment 0.4872794809072897 0.9768296470336224 0.328653496050421 1.0 0.56847510895393 13 P03886,P00403 2 +Joint contracture of the hand 0.3677785745048194 0.9762647271092928 0.3289332947562009 1.0 0.5687473343644621 47 P42892,Q15392,Q9Y619,Q9NR77,Q8IZA0,O75844 6 +Developmental cataract 0.3569207134965079 0.9755268514584878 0.3292989890297157 1.0 0.5689561558319299 58 Q53H12,Q9H1A4,P42766,P18074,Q15800,Q01968,P03886,Q15042,P62847,O76024,Q8WVX9,P48449,P00403,Q99797,Q9NVI7,Q16134,P21912 17 +Renal hypoplasia 0.3874372864662212 0.974042805139825 0.330035286013062 1.0 0.5698045108943464 35 Q9NWS8,Q9UHX1,Q9Y4P3,Q9UBM7,Q9P2D1,Q6PGP7,Q13426 7 +Abnormal metatarsal morphology 0.4110602193296441 0.9734348576602424 0.3303372215336639 1.0 0.5699022396009665 26 Q15392,Q96L58,Q9H9S5,O43505,P16435,O95202 6 +Proximal tubulopathy 0.4200578737415939 0.9706734566791566 0.3317109137187706 1.0 0.5716353505702553 24 Q9P032,Q96CU9,P03886,Q9Y6M9,Q9NPL8,P00403,O43676,Q86Y39 8 +Epistaxis 0.4752533218746217 0.9673194675849645 0.3333843546738348 1.0 0.5728514211550828 14 P04062 1 +Rheumatoid factor positive 0.4831432215103363 0.9672552495109124 0.3334164487326287 1.0 0.5728514211550828 4 P49327 1 +Color vision defect 0.4752143450995982 0.9670904502950056 0.3334988190253023 1.0 0.5728514211550828 14 Q9H061,Q13432 2 +Papilloma 0.5139114784997898 0.9670355157799722 0.3335262794284328 1.0 0.5728514211550828 9 P16615 1 +Cardiomegaly 0.3758532457014652 0.9598788148304904 0.3371162096057136 1.0 0.5767438649894022 39 P04062,P13473,P10253,P49748,Q9Y4P3,Q14739,P54802,P23786 8 +Blistering by anatomical location 0.4552086372921079 0.95981805114915 0.3371467957285587 1.0 0.5767438649894022 3 Q15149,Q9H4L7 2 +Urethral stricture 0.4552086372921025 0.959818051149119 0.3371467957285743 1.0 0.5767438649894022 3 Q15149,P09884 2 +Abnormal pattern of respiration 0.2983440711524531 0.9591153527909628 0.3375006369166942 1.0 0.5771173938590214 194 Q6PJG6,Q9UHX1,Q96CU9,Q15165,P51571,Q9Y619,P06280,P51812,Q9P0J0,O43772,Q13510,P12235,Q86Y39,Q96A33,P47985,P23786,P04062,P03886,P07602,O75844,P51798,Q9NSD9,P10253,O14678,P49748,Q96L58,P22695,Q96KP1,Q9NZJ7,Q7KZN9 30 +Profound hearing impairment 0.5022740966245383 0.9585574711914018 0.337781726035135 1.0 0.5773855405295207 5 Q9NR77 1 +Retrognathia 0.3440151575244517 0.9568425244550032 0.3386467448828119 1.0 0.5784385208549794 82 Q15392,P04062,Q9UHX1,P37268,O75844,Q15427 6 +Abnormal pyramidal sign 0.3192319045703353 0.9553412070303036 0.3394051753295708 1.0 0.5792282362688592 128 P15289,P42858,Q6PJG6,P01889,Q9Y619,P51812,Q9H9S5,Q9P0J0,Q6DKK2,Q99720,P21912,Q15043,P49902,Q9NR77,O43681,Q9H5V9,Q9Y5P6,P07602,P51648,Q8WVX9,Q15067,O75569,P49327,P11166,P17900,O14773,Q9NZJ7,Q9NZ08 28 +Large intestinal polyposis 0.515543641248216 0.9550237906647784 0.3395656660640656 1.0 0.5792282362688592 8 P28340,P21912 2 +Oculomotor apraxia 0.4036943638580446 0.9549405271269163 0.3396077734817848 1.0 0.5792282362688592 27 O43292,P04062,O14773 3 +Metaphyseal widening 0.4299754238115744 0.951387506324581 0.3414077001959743 1.0 0.5815893881896262 21 P16278,O95613,Q96L58,Q14739,Q96HY6 5 +Prematurely aged appearance 0.3661556764962713 0.9491888183893668 0.3425245874978659 1.0 0.5831327348901009 46 Q13535,O95613,Q9Y4P3,Q13315,O75844,Q13126,P48651,Q9Y487 8 +Prominent forehead 0.3427367129404047 0.9480919649341392 0.343082638416637 1.0 0.5838688417888994 85 Q15392,P42858,P42345,Q9UHX1,Q96L58,Q7LGA3,O43292,Q9NSD9,P51812,Q6PGP7,Q14739,P31939,P23786 13 +Macular coloboma 0.4270711785297605 0.9474686305563712 0.3434000337153309 1.0 0.5841950042626978 2 Q92620 1 +Retinal dysplasia 0.5139445189766786 0.946872425027666 0.3437037907324192 1.0 0.5844977348985431 8 Q8NAT1,P53701,Q9H9S5,O43505 4 +Congenital sensorineural hearing impairment 0.5138350652012228 0.9463146569113556 0.3439881198107715 1.0 0.5847672172121641 8 Q9P2D1,Q16740 2 +Cerebral calcification 0.3880460839155946 0.9427018988754524 0.3458334018353852 1.0 0.5872601348324349 33 P05067,Q16625,Q96MG7,P03886,P00403,P23786 6 +Dysarthria 0.3013873631254615 0.9427011652125225 0.3458337772065307 1.0 0.5872601348324349 166 P15289,Q96CU9,Q9Y4P3,Q8IV08,Q13426,Q14108,Q9P0J0,Q6DKK2,Q96RL7,O43292,P49770,O43681,P12235,P04062,Q13315,P07602,Q13409,P51648,Q9P2D1,O15118,Q5XKP0,O14773,Q9NZJ7,O75503,Q7KZN9 25 +Abnormal sputum 0.516072755777238 0.9391147484906902 0.3476718328008736 1.0 0.5898637131490504 7 P49327,Q9NZ08,P01889 3 +Stillbirth 0.4904087744442903 0.9385348515282608 0.34796961521918 1.0 0.5898637131490504 12 O75844,P04062,P16435 3 +Preaxial polydactyly 0.4703404439380454 0.9384721628715144 0.3480018161303373 1.0 0.5898637131490504 14 Q9UHX1 1 +Abnormal brainstem mri signal intensity 0.4198656039646574 0.9379333489539042 0.34827866360326 1.0 0.5901115837132129 23 Q9P032,Q96CU9,P03886,Q9NPL8,O43676,Q86Y39 6 +Peptic ulcer 0.4997488673168269 0.9376932333641426 0.3484020822482443 1.0 0.5901115837132129 11 Q9Y4P3,P04062 2 +Metaphyseal cupping 0.4978509832535683 0.9360607878366738 0.349241890723611 1.0 0.5908877728703192 5 Q14739,Q9UBN7 2 +Lipid accumulation in hepatocytes 0.3448334339538494 0.935425732799402 0.3495689405680164 1.0 0.5909451960660899 69 Q8N511,Q15067,Q9NWS8,Q16836,Q9Y6B6,P49748,P28340,Q13426,O43772,Q9NSD9,P23786,Q7KZN9 12 +Abnormal esophagus physiology 0.3008737630306253 0.935254003320302 0.349657413686113 1.0 0.5909451960660899 233 P42858,P01889,Q9UHX1,O75165,P55011,Q9Y619,Q9Y4P3,P06280,Q9BPU6,Q14108,Q99720,O95202,P21912,Q13510,Q96RL7,Q9NR77,Q9UBM7,P16435,Q14739,P12235,Q9Y584,Q96A33,P21964,P04062,O15269,P03886,P07602,Q9P2D1,O76024,Q6ZXV5,Q01105,Q9NSD9,P05067,O15118,O14678,Q15067,P49748,Q8IZA0,O00203,Q9NZJ7,Q03164,P51571 42 +Restrictive ventilatory defect 0.4896957405917184 0.934595200422707 0.3499969534401808 1.0 0.5912241560148314 12 Q96L58,Q9H9S5,P16278 3 +Abnormal erythrocyte morphology 0.2978758666004957 0.9341932144137698 0.350204235332074 1.0 0.5912241560148314 200 Q96CU9,P06280,P09601,Q13426,Q14108,Q9P0J0,Q9BQT8,P21912,Q13510,Q96RL7,Q9Y6B6,O95613,Q15904,Q9UBX3,P00374,O15360,P47985,P42766,P04062,P03886,P07602,Q9P2D1,O76024,P51798,P00403,Q9NSD9,O75845,P22830,O14678,P62847,Q9NZJ7,Q6P4A7,Q7KZN9 33 +Abnormal nephron morphology 0.3465792274426553 0.9336148806477584 0.3505025865608213 1.0 0.5912981180688366 67 O95470,P49327,O43819,P01889,P03886,Q9Y4P3,P06280,P00403,Q14108,Q9NZ08,P23786,P21912 12 +Deformed sella turcica 0.4972262773722667 0.932886627695196 0.350878507408441 1.0 0.5914340982822122 5 Q96AX1,O75431,O60568,P08236 4 +Abnormal heart valve physiology 0.3384758734371703 0.9327189652498908 0.3509650901773695 1.0 0.5914340982822122 95 Q9UHX1,P01889,Q9Y4P3,P14854,P06280,P51812,O43819,P16278,Q9UL01,Q15904,Q6PGP7,P04062,Q9P2D1,Q8WVX9,O75844,Q6ZXV5,P49327,Q96L58,Q9NZ08 19 +Abnormal palmar dermatoglyphics 0.3481525094332893 0.931937583666656 0.3513687830012224 1.0 0.5916851634011161 65 Q13535,Q9UHX1,Q9P2D1,Q15907,P51812,O95202,Q9Y487 7 +Hemiparesis 0.43669254762695 0.9303277134966524 0.352201433049133 1.0 0.5922151985486935 19 P49327,P42345,P01889,P03886,P00403,Q9NZ08 6 +Nuclear cataract 0.4760501291907272 0.9299944097530904 0.3523739789103923 1.0 0.5922151985486935 4 Q99797 1 +Sclerocornea 0.50263526685719 0.9298507845157602 0.3524483478233184 1.0 0.5922151985486935 10 O75569,O95202,Q9UBM7 3 +Decreased number of peripheral myelinated nerve fibers 0.4478001037597964 0.9289643903462664 0.3529075410751201 1.0 0.5925581625713798 17 Q8TB36,Q9NR77,Q96RL7,O15269 4 +Flat face 0.4139463377968209 0.926486710999782 0.3541931000680876 1.0 0.594206261384151 24 O14974,Q9UM00,Q96L58,O75381,Q9NRZ9,Q15555,Q96C86,Q03164,Q9Y487 9 +Chondrosarcoma 0.4490808287131778 0.9260981780470676 0.3543949607541792 1.0 0.594206261384151 3 O75874,P48735 2 +Abnormal erythrocyte enzyme level 0.4418089692350502 0.9260871756414536 0.3544006780661821 1.0 0.594206261384151 18 P42766,P62847 2 +Abnormality of the vertebral endplates 0.5092708446265986 0.9230753924059568 0.3559679173561363 1.0 0.5961180847581646 8 Q96L58,P51798 2 +Arrhinencephaly 0.4875797951168511 0.9229098780106724 0.3560541724502597 1.0 0.5961180847581646 12 Q15427,Q9P2D1,Q8TAA9 3 +Calvarial skull defect 0.512776635739694 0.922617746372409 0.3562064441825054 1.0 0.596158191524467 7 O95202 1 +Prenatal maternal abnormality 0.4570628317598857 0.9220229795688673 0.3565165893968229 1.0 0.5962476869465945 15 Q14739,O43772,P16435 3 +Restlessness 0.3688310011527727 0.921026569918848 0.3570365552560617 1.0 0.5964731520027554 40 P05067,P42892,P04062,Q15165,P48449 5 +Abnormality of the lymph nodes 0.3651609162042858 0.919362897274428 0.3579057892262309 1.0 0.5972836641562179 44 Q13510,P49327,Q13546,Q5HYI8,Q13315,Q9P2D1,P51798,Q14691,Q13426,Q9NZ08 10 +Abnormal sternum morphology 0.3200896915624132 0.9186105219625478 0.3582993264428593 1.0 0.5972941050066467 122 Q13510,P04062,P16278,Q9UHX1,Q96L58,Q9Y619,Q9Y4P3,Q96AY3,Q7LGA3,P51812,Q03164,Q14739,Q9NVI7,O95202,Q9NSD9,Q9Y487,Q96A33,P21912 18 +Abnormal morphology of the radius 0.4659305685465771 0.91261656387902 0.3614442396767159 1.0 0.6012423693297608 14 Q96L58,Q15427,Q13535 3 +Abnormal circulating albumin concentration 0.3858569042298186 0.9084356955106578 0.3636480736858938 1.0 0.6036116292764068 32 O95470,Q5XKP0,Q9Y6B6,Q6PGP7,Q9NSD9 5 +Hypocalcemia 0.4495932900302166 0.9072089265159408 0.3642963241372992 1.0 0.6042862741128598 16 P49748,P51798,Q9NSD9,Q9P2D1 4 +Abnormality of the amniotic fluid 0.3360140820251906 0.9066494697229964 0.3645921925075155 1.0 0.6045308088472224 96 Q9UHX1,Q9UM00,Q7LGA3,Q9UBM7,Q6PGP7,P16435,Q14739,P43034,O15360,P23786,P27635,P21964,P04062,Q9P2D1,O75844,P51798,Q9NSD9,Q70HW3,Q96L58,P50570,Q9BT22,Q9NVI7 22 +Abnormal urine cytology 0.3636012654698361 0.904767364679882 0.3655886444234582 1.0 0.6057506569156158 44 P09601,Q14108 2 +Abnormality of the hallux 0.3510226920524355 0.904367887270796 0.3658003601721238 1.0 0.605885373746769 56 P42858,P04062,Q9UHX1,Q96L58,Q7LGA3,O95202,Q15427 7 +Hemianopia 0.5053384585556895 0.9030866901681456 0.3664798873875536 1.0 0.6066653404973504 8 P03886 1 +Short chin 0.4836412194518552 0.9011835561940286 0.3674907324903151 1.0 0.6076021150000015 12 Q13426 1 +Abnormality of the wrist 0.3867395664990207 0.900604238369884 0.3677987802958449 1.0 0.607895102545178 31 Q13510,O75844,Q96L58,P16278 4 +Irregular vertebral endplates 0.5105135563587514 0.8950191251595093 0.3707768644428784 1.0 0.6111159751023368 6 Q96L58 1 +Decreased number of large peripheral myelinated nerve fibers 0.5105048083147317 0.8949761947099897 0.3707998135629546 1.0 0.6111159751023368 6 Q8TB36 1 +Hypoplastic facial bones 0.4369279938803735 0.8946889025699981 0.370953412608844 1.0 0.6111523244612375 18 Q15427,Q9Y4P3,P16435 3 +Retinal hemorrhage 0.5102469087521911 0.8937106507901328 0.3714767252656386 1.0 0.6114165404982775 6 Q9Y487 1 +Neurodegeneration 0.3907721734617635 0.8936511183984053 0.3715085867039684 1.0 0.6114165404982775 28 Q15165,P42858,P17900 3 +Glucose intolerance 0.3275435773285028 0.8929885360215685 0.3718633118947927 1.0 0.6117836214813055 110 Q9P032,Q96CU9,Q5HYI8,P03886,Q9Y4P3,Q13315,O95613,Q8TAA9,O76024,O75844,P28340,Q9NPL8,Q13426,P00403,Q06136,O43676,P12235,Q86Y39 18 +Thin ribs 0.462315283272757 0.8914515479135775 0.372686973961021 1.0 0.6124880371499483 14 O75431,O95831,Q9Y619,Q9UBN7,P50570,O75844 6 +Abnormality of the ulna 0.3644957181438284 0.888542833507666 0.3742488259241241 1.0 0.6146200230623827 41 Q96L58,Q9Y4P3,O15360,Q9P2D1,P16435,O95202,Q15427 7 +Single transverse palmar crease 0.3546750235703922 0.8868586657283279 0.3751549979237993 1.0 0.6158905018918628 50 Q15907,O95202,P51812,Q9UHX1 4 +Hypergonadotropic hypogonadism 0.4407759729978149 0.8847367928967502 0.3762986067600735 1.0 0.6166784222247977 17 P48449,Q16740 2 +Deep palmar crease 0.480600763462864 0.8844355555683583 0.376461136454044 1.0 0.6167272355308493 12 Q9Y487 1 +Bicornuate uterus 0.4977628759124421 0.8834463924876064 0.3769951344191447 1.0 0.617384347730471 9 O15360,Q15427 2 +Coarctation of aorta 0.3645237820453323 0.8820537427906163 0.3777477452406685 1.0 0.6178049975244679 40 P42766,Q9UHX1,O14678 3 +Adenocarcinoma of the colon 0.4234758885560594 0.8818287431886612 0.3778694255392725 1.0 0.6178049975244679 20 P28340,P42766,P62847 3 +Muscle spasm 0.3493669156545838 0.880235077126702 0.378731974877343 1.0 0.618050142353402 54 P53985,Q9Y5P6,P04062,O75165,Q15165,P13473,P49748,Q9NR77,P06280,Q9H9S5,P12235,P23786 12 +Hyperactive patellar reflex 0.4968582279249369 0.8787804198986675 0.3795203446680166 1.0 0.6191192139492997 9 P13073,P21912 2 +Abnormal head movements 0.4792607058297924 0.8770612361353155 0.3804533780971859 1.0 0.6199882127813138 12 Q99720 1 +Abnormal paranasal sinus morphology 0.3885656772476614 0.876427892263711 0.3807974606624187 1.0 0.6203313472081338 28 Q03519,Q13432,Q03518 3 +Hypomimic face 0.4784455195984865 0.8725775541059066 0.3828933793534324 1.0 0.6230902418480023 12 P12235,P04062,Q15043 3 +Abnormal renal physiology 0.2944783196617596 0.8709192687676055 0.3837982349708493 1.0 0.6240268388154734 170 Q13277,Q9P032,Q96CU9,Q9Y4P3,P09601,Q14108,O43772,O43676,P21912,O15360,Q86Y39,P23786,O95470,Q9NWS8,Q16625,P04062,P03886,Q9P2D1,P00403,Q8TAA9,Q9BT22,Q9NPL8,Q9NZ08 23 +Caesarian section 0.4646818447168769 0.8705385084438448 0.3840061842818421 1.0 0.6240268388154734 4 P33991,O14802,O60313 3 +Reticular hyperpigmentation 0.4136522753792333 0.8701834195446326 0.3842001754669999 1.0 0.6241237815453432 2 P09884 1 +Abnormal aortic arch morphology 0.4778199159527492 0.8691378124658403 0.3847717567925883 1.0 0.624833828052557 12 Q9UHX1,Q9P2D1 2 +Abnormality of corneal size 0.3614367726206598 0.8678685177125207 0.3854663153467159 1.0 0.6249360922618954 42 Q9NWM8,Q9Y5P6,O15347,Q96L58,Q9Y4P3,Q15042,Q15555,Q9H9S5,Q96EK5,O43505,Q8NAT1,O95202,O75845 13 +Webbed neck 0.3679740857229031 0.867314727633077 0.3857695893594484 1.0 0.6249360922618954 38 P42766,P62847,O75844,Q03164,O95202 5 +Crackles 0.4382842135979116 0.866953042051771 0.3859677391640184 1.0 0.6249360922618954 3 Q86TI2,O95453 2 +Honeycomb lung 0.4382842135979116 0.866953042051771 0.3859677391640184 1.0 0.6249360922618954 3 Q86TI2,O95453 2 +Optic atrophy 0.2938903197976849 0.8665659804027452 0.3861798601076434 1.0 0.6249361302891366 198 P15289,Q6PJG6,Q9P032,Q96CU9,P06280,P51812,Q9H9S5,Q9P0J0,O95202,Q9H061,P31939,Q15043,P49902,P16278,Q9UBM7,O43292,P49770,P50897,O43681,Q86Y39,P21964,P03886,P07602,Q9P2D1,O76024,P51798,P00403,Q15067,Q5XKP0,Q15907,Q9NZJ7,O43505,Q9NVI7,Q7KZN9 34 +Intestinal malrotation 0.3806769419393271 0.8661199862835114 0.3864243659806865 1.0 0.6251140683656927 32 Q15392,P55011,Q9UBM7,Q14739,O95202,Q9NSD9 6 +Combined immunodeficiency 0.4903466826886253 0.8652387687787466 0.3869077506368747 1.0 0.625330631780157 10 Q13426,Q9P2D1 2 +Visual impairment 0.292496215253646 0.8651398684516916 0.3869620246164338 1.0 0.625330631780157 303 P15289,P42858,Q13277,Q6PJG6,Q9UHX1,Q96CU9,Q9P032,P55011,Q9Y4P3,P14854,Q9H9S5,Q13426,P10412,O43676,Q9H061,P31939,P21912,Q15043,P16278,Q9Y287,Q9Y6B6,Q92974,Q7LGA3,O43292,P49770,P50897,P48449,O43681,P12235,O15360,Q86Y39,Q96N66,Q96A33,P13473,P03886,P07602,Q9P2D1,P51798,Q9Y6M9,P00403,Q01105,P49327,Q5XKP0,P17900,P78527,O14773,Q15907,Q9NZJ7,O75503,Q9NPL8,O43505,Q6P4A7,Q9NZ08,P37268,Q13432 55 +Abnormal odontoid tissue morphology 0.3561472448756299 0.8644899203028765 0.3873188151364186 1.0 0.6256895741042423 47 Q13535,P16278,O95613,Q96L58,Q9Y4P3,Q96AY3,Q9UBM7,P51648,P48651 9 +Urinary incontinence 0.3578999841465924 0.8606055071042089 0.3894553518005477 1.0 0.6280491372666936 45 P15289,Q9H5V9,O43681,P07602,Q8TAA9,Q8WVX9,P50570,P51812,Q9NZJ7,Q99720 10 +Aplasia hypoplasia of the skin 0.3453865389468435 0.8594484786397792 0.3900931333000499 1.0 0.6288593675614268 59 Q9NWM8,Q15392,Q9Y619,Q96L58,O75844,P28340,Q13126,O95202 8 +Hypoparathyroidism 0.4755297354927212 0.8565549694014388 0.3916908812571285 1.0 0.630297944820752 12 P03886,P00403 2 +Recurrent paroxysmal headache 0.4843609252660621 0.8553053466560899 0.392382128381834 1.0 0.6306442109371043 11 P03886,P00403 2 +Abnormal morphology of the musculature of the neck 0.4558532561450818 0.8537051662712999 0.393268370907611 1.0 0.6315263799338178 14 Q99720 1 +Kinetic tremor 0.3610462311441085 0.8506082041738454 0.3949870305206704 1.0 0.6333387832633873 40 P15289,Q9Y287,P07602,Q9NZJ7,Q14108 5 +Limited elbow extension 0.4742840181712554 0.8497169815335364 0.3954824548836189 1.0 0.6334261801584687 12 Q96L58,Q15427,P16435 3 +Long fingers 0.3351806779757773 0.8496844297485012 0.3955005572959924 1.0 0.6334261801584687 81 P42892,Q9UHX1,Q96L58,Q15907,P51812,Q06136,O95202,P23786 8 +Mortality aging 0.3243250834520491 0.8494954053035726 0.3956056858029799 1.0 0.6334261801584687 110 Q6PJG6,Q13277,Q96IX5,Q9Y4P3,P51812,Q9H9S5,P16278,Q15904,P16435,Q14739,Q9NWS8,P04062,P07602,O75844,P05067,Q15067,P49748,Q9NZJ7,Q9BT22,Q9NPL8,Q9NVI7 21 +Abnormality of the protein c anticoagulant pathway 0.4098599766627797 0.8484660599224575 0.3961784664449963 1.0 0.6336127900528238 2 P34949 1 +Reduced protein c activity 0.4098599766627797 0.8484660599224575 0.3961784664449963 1.0 0.6336127900528238 2 P34949 1 +Reduced protein s activity 0.4098599766627797 0.8484660599224575 0.3961784664449963 1.0 0.6336127900528238 2 P34949 1 +Limb girdle muscle weakness 0.3896744090252616 0.8476739497030907 0.396619578008307 1.0 0.6340999860380573 27 P12235,Q13126,P07602 3 +Abnormal soft palate morphology 0.3350507392561375 0.8452734901187076 0.3979581587605467 1.0 0.6349661596611551 73 Q9NWM8,Q15392,P42766,Q9Y619,P62847,Q9P2D1,Q6PGP7,Q9H9S5,P48651,O43505,O15360,Q15427 12 +Motor seizure 0.3219797018408233 0.8448937560137393 0.3981701609844406 1.0 0.6349661596611551 113 Q6PJG6,P55011,Q9Y619,Q2M389,Q9NZ01,P21912,Q13510,P16278,O43292,Q9UBX3,P13073,P43034,Q96N66,P27635,Q96N67,P04062,P03886,P07602,Q8WVX9,Q01105,P11166,Q5XKP0,Q96C86,Q9NZJ7,O75503 25 +Aplasia hypoplasia involving the skeletal musculature 0.4824055254250575 0.8448789705174482 0.3981784169735025 1.0 0.6349661596611551 11 Q9NR77,Q9H9S5,Q9Y487,O43505 4 +Abnormal renal insterstitial morphology 0.4543157777605582 0.8447423449617473 0.3982547114189854 1.0 0.6349661596611551 14 P23786 1 +Adult onset 0.3393751981088642 0.8438279462394186 0.3987655566394814 1.0 0.6355625304106453 66 P42345,O15118,P21912,P04062,P07602,Q8IV08,P38435,O76024,Q9NZJ7,P12235,Q07864,Q14566 12 +Arthrogryposis multiplex congenita 0.3652278779162222 0.84315286762194 0.3991429544241798 1.0 0.6358416278871488 38 Q15392,P04062 2 +Cardiac conduction abnormality 0.3652133549971808 0.843025139449572 0.3992143841039202 1.0 0.6358416278871488 38 P21912,P49748,P03886,Q99959,P0DP25,P00403,O43772,P23786 8 +Abnormality of ocular smooth pursuit 0.4063414026161187 0.8421631782721748 0.399696621449916 1.0 0.6361172001267036 23 Q13426 1 +Gastrointestinal inflammation 0.406321393418745 0.8420218556469861 0.3997757199681733 1.0 0.6361172001267036 23 P49327,Q13546,P01889,P49748,Q6PGP7,P08183 6 +Abnormal anterior eye segment morphology 0.2862778665736937 0.840521496492494 0.4006160539399099 1.0 0.6361172001267036 327 P42858,Q9UHX1,P01889,P55011,Q9Y4P3,P06280,P51812,Q9H9S5,Q13426,P10412,Q9BQS8,Q9BPU6,Q8NAT1,O95202,Q2TAA5,Q16134,P21912,Q13510,P16278,Q9Y287,Q92974,Q9UL01,Q9NR77,O15228,O75381,Q7LGA3,Q9UBM7,P48449,Q14739,P12235,O15360,P23786,Q9NWM8,P21964,P42766,P04062,Q03519,Q16625,P03886,P51648,Q9P2D1,O75844,O76024,Q13126,P00403,Q03518,Q06136,Q6ZXV5,O75845,P49327,Q15800,Q96L58,P62847,O00203,P10619,Q99797,O43505,Q9NVI7,Q9NZ08 59 +Decreased plasma carnitine 0.4631877076854808 0.8400265657508384 0.4008934915994377 1.0 0.6361172001267036 13 P49748,O43772,P23786 3 +Abnormal nerve conduction velocity 0.3545838985038176 0.8389994583409912 0.4014696135604585 1.0 0.6365749456177523 46 P15289,O43681,O15269,Q9Y619,Q9NR77,P07602,Q9NZJ7,Q99720,Q8TB36 9 +Abdominal wall muscle weakness 0.4585522475189787 0.8386464519272564 0.4016677355394999 1.0 0.6365749456177523 4 P36507,P46976,P21359 3 +Migraine 0.405501997558197 0.8362357164363399 0.4030223090795255 1.0 0.637535460668531 23 P05067,P49327,P01889,P03886,Q9NZ08,P00403,P12235 7 +Aplasia hypoplasia of the uterus 0.427246904180829 0.8326001215861247 0.4050702904098067 1.0 0.6392103719493247 18 O95202,Q16740 2 +Abnormality of central nervous system electrophysiology 0.2991647346931602 0.8324025219118901 0.4051817790337411 1.0 0.6392103719493247 159 Q01968,P55011,Q9BQE5,Q2M389,Q9H9S5,Q14108,Q9NZ01,O95202,Q2TAA5,O75381,O43292,Q9UBX3,P13073,P50897,P48449,P43034,Q96N66,Q96A33,P27635,Q96N67,P21964,Q9Y5P6,P03886,P07602,P00403,Q15067,P11166,Q96C86,Q9NVS9,Q9NZJ7,O75503,Q8IWS0 32 +Abnormality of temperature regulation 0.3216452991932403 0.8309433981827714 0.4060056055858601 1.0 0.6400753456233139 112 Q13546,P06280,O43772,Q2TAA5,Q13510,Q9NR77,P49770,Q14739,P47985,P23786,P03886,Q13315,P07602,Q9P2D1,P51798,P00403,P10253,P49327,Q5XKP0,P49748,P50570,Q9NZJ7,Q9NZ08 23 +B cell lymphoma 0.4768230395925552 0.8297638874777201 0.4066722921509105 1.0 0.6402573599908947 5 Q13315 1 +Long penis 0.4063593932322066 0.828476939240317 0.4074004495869197 1.0 0.6410071364901323 2 O14802 1 +Increased intracranial pressure 0.4318030870828083 0.8284345140092999 0.4074244670803617 1.0 0.6410071364901323 17 P49327,P07602,Q9NZJ7,Q9NZ08,P21912 5 +Hip dysplasia 0.3439050087450881 0.8271916882821406 0.4081284219441428 1.0 0.6414630068851446 55 P42858,Q13535,Q9UHX1,P55011,Q96L58,Q7LGA3,Q15907,Q9NVI7,O95202,Q96A33 10 +Anemia of inadequate production 0.3378202863975535 0.8265638039746218 0.4084843402278799 1.0 0.6416701618949441 66 P22830,P49327,P42766,Q15904,P62847,O76024,Q9UBX3,P00374,Q9BQT8,Q6P4A7,O15360,P47985 12 +Milia 0.4553415061296032 0.8219952948764603 0.4110795747722857 1.0 0.6441402038421719 4 Q15149,P50336,Q9H4L7 3 +Aplasia hypoplasia of the phalanges of the hand 0.3411333648543423 0.819758972281747 0.4123535240757858 1.0 0.6457008671574321 60 P42345,Q9UHX1,O95613,P38435,O75844,P51812,P51798,Q03164,P16435,Q14739 10 +Cholecystitis 0.4853190606170863 0.8194632164558948 0.412522180166333 1.0 0.6457473211094283 9 P15289,Q9NZJ7,P07602 3 +Abnormality of hair pigmentation 0.3897289611526804 0.8135302657358764 0.4159141009897968 1.0 0.6493067584672703 26 P49327,Q13315,Q9UBM7,O00203,Q13126,Q6PGP7,P37268 7 +Aplasia hypoplasia of the fibula 0.4839087231490291 0.8122416165448068 0.4166530039922897 1.0 0.650241806028948 9 Q15427 1 +Hyperkinetic movements 0.4669081281316536 0.8093294881002489 0.4183256489130142 1.0 0.6519761706977069 12 Q9NZJ7,P07602 2 +Bilateral tonic clonic seizure 0.3308370983370328 0.8060449004666709 0.420216960033531 1.0 0.6533895569999281 86 Q13510,P04062,Q96RL7,P49748,P03886,P07602,O43292,P27544,P51812,Q9NZJ7,P00403 11 +Absent toe 0.3927064535982992 0.8034264469901371 0.4217282939688864 1.0 0.6555201250516717 25 O95202,Q15427,Q9UHX1,Q7LGA3 4 +Osteosarcoma 0.4006297870492751 0.8018811880238521 0.4226216889825385 1.0 0.6562501226647305 23 Q13126,P42766 2 +Abnormality of peripheral nerves 0.3460227917649696 0.8013948920963527 0.4229030712741521 1.0 0.656467647557538 50 P15289,Q96RL7,O43681,O15269,Q9Y619,Q9NR77,P07602,Q9NZJ7,Q99720,Q8TB36 10 +Wide nasal ridge 0.4512551079976712 0.8008622348814315 0.4232114051624722 1.0 0.6567268498279378 4 P27635,Q15022,O14802 3 +Shortening of all distal phalanges of the fingers 0.4736366657580795 0.7982713494722835 0.424713040430531 1.0 0.6577534876261318 11 P51812,Q9H5V9,P16435 3 +Intracranial hemorrhage 0.383073597471932 0.7973570709700539 0.4252436837653683 1.0 0.6580319358848934 27 O75844,P04062,P05067,P23786 4 +Fetal distress 0.391856956295076 0.7972133355877999 0.4253271423724354 1.0 0.6580319358848934 25 Q9P032,Q96CU9,Q9NVI7,P03886,Q9NPL8,O43676,Q86Y39 7 +Paralysis 0.3466543627763338 0.7953600986868435 0.4264040634476553 1.0 0.6590879049143102 49 P04062,Q15165,P17900,Q9NR77,P51798,Q8TB36,P21912 7 +Death in infancy 0.3377356087403327 0.7953064453596013 0.4264352652114542 1.0 0.6590879049143102 62 Q15067,O43819,Q6PJG6,Q13277,Q9NWS8,P16278,P04062,P49748,Q15904,P07602,Q9UBN7,P50570,Q9BT22,Q9NZJ7 14 +Limitation of joint mobility 0.3241285010568722 0.794040033365259 0.427172125881212 1.0 0.6597877981529625 103 P01889,Q9Y4P3,P16278,O95613,Q7LGA3,P48651,P16435,P23786,P51648,O76024,O75844,Q15427,Q13535,Q96L58,Q96AY3,Q8TAA9,Q9BT22,P37268,P54802,Q9BTV4 20 +Adenocarcinoma of the intestines 0.403100563454433 0.7926438083582075 0.4279853773453648 1.0 0.6604139926768383 22 P28340,P42766,P62847 3 +Hypoplasia of the musculature 0.4884298966288115 0.7873276828896091 0.4310900683908778 1.0 0.6642423858078998 6 Q9Y487 1 +Abnormal circulating ige level 0.4881707164952937 0.7860732689442204 0.4318245636710425 1.0 0.664763725253699 6 Q96MG7 1 +Fatigue 0.3296882543405343 0.7852134979511686 0.4323284027549985 1.0 0.6653189000330317 82 Q70HW3,P04062,Q13423,Q15165,Q5HYI8,Q13315,P07602,Q9NZ08,Q9NZJ7,Q14739,P12235,P21912 12 +Impaired horizontal smooth pursuit 0.4225269915377985 0.7814389656498854 0.4345443609565453 1.0 0.6678442279206449 3 P35251,Q9NW08 2 +Duplication of hand bones 0.3377778208494595 0.7790314645412478 0.435961180189921 1.0 0.6695787250123547 59 Q15067,P21964,P42766,Q9UHX1,O15360,P62847,Q9UBM7,Q9P2D1,Q14739,O95202 10 +Dental crowding 0.3695386143919615 0.7753864049002447 0.4381113660647153 1.0 0.672362707342984 32 Q92643,P27635,Q13535,Q9UL01,Q01968,Q9UBM7,O75844,P28340,P51812,Q01105,Q96A33 11 +Aplasia hypoplasia of fingers 0.3252785818728617 0.7752228630183557 0.4382079805928875 1.0 0.672362707342984 97 Q13510,P42766,Q9UHX1,O15360,P62847,Q9P2D1,P38435,O75844,P51812,P13073,Q03164,P51798,P16435,O95202,Q15427 15 +Respiratory failure 0.3345559569043697 0.7744923713202022 0.4386396777605064 1.0 0.672802886390001 64 Q13510,Q70HW3,Q5XKP0,P10253,Q15165,Q9Y619,P07602,Q9BT22,Q9NZJ7,Q9NSD9,P23786 11 +Severe cytomegalovirus infection 0.4210679894952009 0.773580461080854 0.4391789303083917 1.0 0.673407693139534 3 Q9H0U3,Q7L590 2 +Bile duct proliferation 0.4652767559866407 0.772012325698014 0.4401071273239929 1.0 0.6743857894285195 5 Q9NSD9 1 +Aganglionic megacolon 0.4068258515339 0.7705265852848171 0.4409875911515011 1.0 0.6752681352239981 20 P42892,Q15427,O15360,Q9UBM7 4 +Multifocal cerebral white matter abnormalities 0.4843437038783833 0.7675810285504611 0.4427361369388976 1.0 0.6770744214016189 6 Q9Y619,P10253 2 +Very long chain fatty acid accumulation 0.4442792581944589 0.7649554183499655 0.4442980921235437 1.0 0.6790160973703896 4 O75381 1 +Functional abnormality of the gastrointestinal tract 0.289837231894086 0.7628815497393479 0.4455340405162407 1.0 0.679856951097908 288 Q13546,P42858,Q9UHX1,P01889,Q5HYI8,Q9Y619,Q9Y4P3,P55011,P06280,Q14108,Q99720,O95202,P21912,Q13510,P42892,Q96RL7,Q9NR77,Q9UBM7,Q6PGP7,P16435,Q14739,P08183,P12235,Q9Y584,Q96A33,P21964,P04062,O15269,P03886,P07602,Q9P2D1,O76024,P00403,Q6ZXV5,Q01105,Q9NSD9,P05067,O15118,O14678,Q15067,P49327,P49748,Q8IZA0,O00203,Q9NZJ7,Q03164,Q9NZ08,P51571 48 +Xerostomia 0.4400854956587653 0.7621918276950345 0.4459455229045104 1.0 0.6799681323972285 14 Q14739,Q15165 2 +Widely spaced teeth 0.3642217276370127 0.7612143253531787 0.4465290632129965 1.0 0.6805106827287446 34 P51812 1 +Abnormality of the metaphysis 0.3371902602475563 0.7610066805526707 0.4466530770288806 1.0 0.6805106827287446 56 P16278,O95613,Q96L58,Q9UBN7,Q9P2D1,P51798,Q13126,Q14739,Q96HY6,Q07864 10 +Microglossia 0.4434023385512687 0.7604579639229093 0.4469808869593659 1.0 0.6805778289610949 4 Q9UBM7 1 +Aplasia hypoplasia affecting bones of the axial skeleton 0.2920193581026504 0.7602957592574958 0.447077816183655 1.0 0.6805778289610949 255 Q15392,P42858,Q6PJG6,Q9UHX1,P55011,Q9Y619,Q9Y4P3,Q86XL3,Q9H9S5,Q13426,Q96HY6,O95202,P16278,O95613,O15228,Q9UBN7,Q7LGA3,Q9UBM7,P48651,P16435,Q14739,O15360,P42766,P04062,Q16625,Q9P2D1,O75844,Q15427,O14678,Q13535,Q96L58,P62847,Q8TAA9,P28340,Q9BT22,Q03164,Q9NVI7,P37268,Q07864,P51571 40 +Poor wound healing 0.4796675313288908 0.7584962908843291 0.4481539326562977 1.0 0.6819925224766327 7 P04062 1 +Sensory axonal neuropathy 0.4296527345756464 0.7572832613937354 0.4488801769025827 1.0 0.6826505079834367 15 Q8IV08,Q13426 2 +Sparse eyelashes 0.4101402303193017 0.7566108653641268 0.4492830298931185 1.0 0.683039580132012 19 O75844,Q15427 2 +Renal tubular dysfunction 0.3492319885096561 0.7558504146809805 0.4497388861384053 1.0 0.6831161274097108 42 Q9NWS8,Q9P032,Q96CU9,P03886,Q9Y6M9,Q9NPL8,P00403,O43676,Q86Y39,Q16134 10 +Absence of pubertal development 0.4813081890324939 0.7529554003122664 0.4514767152508727 1.0 0.6854773918482205 6 O75844 1 +Megalocornea 0.4557698450021783 0.7487229393181861 0.4540242145511652 1.0 0.688895003528646 12 O95202,Q9Y4P3,Q9Y5P6,Q9H9S5 4 +Neoplasm of the tracheobronchial system 0.3920653442240339 0.7475338661332575 0.4547413681302217 1.0 0.6894798352094853 2 Q9UPY3 1 +Abnormality of the pinna 0.2912907604891112 0.7448948763090047 0.4563352728056329 1.0 0.6908251754817898 249 Q15392,P42858,Q9UHX1,Q01968,Q9Y619,Q9Y4P3,P55011,P78318,P51812,Q9H9S5,Q9BPU6,Q8NAT1,O95202,Q16134,O14617,P42892,Q7Z6Z7,P16278,Q9UL01,O95613,Q15555,Q7LGA3,O15047,Q6PGP7,P48449,Q01433,P16435,P48651,Q96A33,P23786,Q92643,P27635,Q96N67,Q9H5V9,P04062,P42766,P21964,P62266,Q9P2D1,Q8WVX9,O75844,O76024,Q06136,Q01105,Q15427,P11166,Q13535,P62847,Q15907,Q96KP1,Q96EK5,O43505,Q8IWS0,P37268,Q07864,P51571 56 +Middle age onset 0.4671198405094986 0.7443470286891158 0.4566665566827845 1.0 0.6908251754817898 10 P07602 1 +Elevated hemoglobin a1c 0.4155237817333099 0.7438252528932414 0.4569822005373969 1.0 0.6908251754817898 3 O75431,O00330 2 +Abnormality of mouth size 0.3028926227265186 0.7399795971920967 0.4593123744095906 1.0 0.6932020813830567 136 Q15392,P42858,P55011,Q9Y619,Q9Y4P3,P51812,Q9BPU6,P31939,Q9UM00,P16278,Q9UL01,Q9UBN7,Q15555,Q7LGA3,Q9UBM7,Q6PGP7,P48651,P16435,P43034,P21964,P04062,Q9P2D1,O75844,Q01105,Q15427,Q9Y487,P42345,P28340,Q9NVI7,P51571 30 +Hypophosphatemic rickets 0.3906067677946423 0.7393446860147961 0.4596977212098523 1.0 0.6932020813830567 2 P16930 1 +Abnormal urine potassium concentration 0.3906067677946283 0.7393446860147167 0.4596977212099005 1.0 0.6932020813830567 2 P05023 1 +Absent shortened dynein arms 0.3894399066511099 0.7328038261678732 0.4636780873386281 1.0 0.6962664491839905 2 Q86Y56 1 +Absent outer dynein arms 0.3894399066511099 0.7328038261678732 0.4636780873386281 1.0 0.6962664491839905 2 Q86Y56 1 +Respiratory insufficiency due to defective ciliary clearance 0.3894399066511099 0.7328038261678732 0.4636780873386281 1.0 0.6962664491839905 2 Q86Y56 1 +Chronic bronchitis 0.3894399066511099 0.7328038261678732 0.4636780873386281 1.0 0.6962664491839905 2 Q86Y56 1 +Abnormal metacarpal morphology 0.364186402911041 0.7319726825542024 0.4641852414662635 1.0 0.6967292890742502 32 Q96L58,P51812,P16278,P16435 4 +Aplasia of the fingers 0.3698385469313208 0.7309163638420015 0.4648302401718851 1.0 0.6973204055016398 28 Q15427,O15360,P42766,P62847 4 +Thin skin 0.3692871453969182 0.7266569382077299 0.4674361389214005 1.0 0.6996482929860912 28 Q96L58,Q9Y619,O75844,Q13126,P48651 5 +Abnormality of bladder morphology 0.4598314430176786 0.7254904554399494 0.4681511981902164 1.0 0.7003047657843452 11 Q9Y4P3,P16435 2 +Bowing of the arm 0.4753341244862607 0.7242886434504134 0.4688885476002027 1.0 0.700777287329704 6 Q96L58,P16435 2 +Abnormal circulating fatty acid anion concentration 0.4239126654669949 0.7231740793294201 0.4695729415936243 1.0 0.7013832724987054 15 P49748,O43772,P23786 3 +Hepatic cysts 0.436077057793351 0.7230453281913269 0.4696520363201619 1.0 0.7013832724987054 4 Q9UBS4,Q9UGP8,O43909 3 +Colitis 0.4592492160387816 0.722439752866864 0.4700241536494296 1.0 0.7014880237247832 11 P49748,P49327,Q6PGP7 3 +Abnormal urine carbohydrate level 0.4330020121659474 0.7214315882377221 0.4706440174818111 1.0 0.7021875739307947 14 P16278,Q01968,Q9Y5W7,Q6PGP7,P10253 5 +Wide mouth 0.3249933304093901 0.7201367538566227 0.4714408000096257 1.0 0.7029649011930312 70 P55011,Q9Y4P3,P15586,P51812,Q9BPU6,P31939,Q7Z6Z7,Q9UM00,P16278,Q9UBN7,Q7LGA3,Q9UBM7,Q6PGP7,P48651,Q01105,Q15427,P42345,P11166,P51571 19 +Abnormality of the parathyroid gland 0.3959753447108134 0.7200931659371651 0.4714676349800872 1.0 0.7029649011930312 21 P03886,P00403,Q9P2D1 3 +Emphysema 0.4585719091630837 0.7188929674241676 0.4722068698794079 1.0 0.7037872277604652 11 Q9NSD9,Q03519,Q03518 3 +Tics 0.4685800805221507 0.7184601607827227 0.4724736038280006 1.0 0.7037872277604652 8 Q9UHX1 1 +Abnormal macular morphology 0.3636474814058292 0.7149175164803758 0.4746600126130689 1.0 0.7061384625681454 31 P04062,P50897,P51648 3 +Leukoencephalopathy 0.3196418926615934 0.7129133923017618 0.4758993514903689 1.0 0.7077555656287624 99 P15289,Q9P032,Q9UHX1,Q96CU9,P17900,P03886,P07602,Q9Y6M9,Q9NZJ7,O75503,Q9NPL8,Q9H9S5,P49770,O43681,O43676,O95202,Q86Y39,P51571 18 +Upper limb postural tremor 0.4336802474539327 0.710868709558697 0.4771655976792854 1.0 0.7094116373817473 4 Q9NR77 1 +Hypomethioninemia 0.4091041727458486 0.7096027834703441 0.4779504930517566 1.0 0.7103512446316255 3 Q99707,Q9Y4U1 2 +Postural instability 0.4171046079015413 0.7086147521382671 0.4785635791712987 1.0 0.7110349820370496 16 P04062,O75165,Q9NR77,P35251,Q8WVX9,O75503 6 +Difficulty walking 0.3233557276171823 0.7072515593118687 0.4794101626609761 1.0 0.7120650945405674 78 Q13510,Q15067,P15289,P42858,Q15041,O43681,Q9BUK6,Q9NR77,P07602,O14773,Q15907,O43292,Q9NZJ7,Q9H9S5,Q99720 15 +Tracheal stenosis 0.4715505972611254 0.7062198178716812 0.4800514478884365 1.0 0.7126827365611917 6 O95613,Q96HY6 2 +Aplasia hypoplasia involving the pelvis 0.4166861817963397 0.7060889951222121 0.4801327949712721 1.0 0.7126827365611917 16 O75431,O95831,Q96L58,Q99575,Q96HY6,O95202 6 +Spinal deformities 0.4686144362942848 0.7046090428829236 0.481053569392055 1.0 0.71359351321695 7 Q9H9S5,Q9Y5P6,Q8TB36 3 +Abnormal peripheral nervous system physiology 0.3321111852277592 0.7037931491572923 0.4815616007377712 1.0 0.7138470058005876 54 P15289,Q96RL7,O43681,O15269,Q9Y619,Q9NR77,P07602,Q9NZJ7,Q99720,Q8TB36 10 +Pseudohypoaldosteronism 0.3841890315052675 0.7034912908279305 0.4817496323798873 1.0 0.7138470058005876 2 Q13618 1 +Microdontia 0.3590056710848618 0.7034203609412075 0.4817938213616204 1.0 0.7138470058005876 33 Q9UM00,O95613,Q9Y619,Q9Y4P3,Q96L58,Q7LGA3,Q9Y487,Q96A33 8 +Facial hemangioma 0.451157736030758 0.7021994150795144 0.4825548103443442 1.0 0.7138470058005876 5 P16435 1 +Ventriculomegaly 0.2855488127123172 0.7018984479924038 0.4827424968800431 1.0 0.7138470058005876 202 Q15392,P42858,Q9UHX1,Q96CU9,P14854,Q86XL3,P51812,Q9H9S5,Q9BPU6,Q13426,Q8NAT1,O95202,O43819,Q96RL7,Q9UM00,P16278,Q9UL01,O95613,Q9UBM7,P42695,P43034,O15360,P23786,Q16625,P04062,Q9Y5P6,P07602,Q9P2D1,Q96SN8,Q6ZXV5,Q01105,Q9Y487,P42345,P51970,Q96KP1,Q9NZJ7,Q9NPL8,O43505 38 +Prelingual sensorineural hearing impairment 0.3838973162193698 0.7018688888118116 0.4827609324635054 1.0 0.7138470058005876 2 P23634 1 +Childhood onset sensorineural hearing impairment 0.3838973162193698 0.7018688888118116 0.4827609324635054 1.0 0.7138470058005876 2 P23634 1 +Scleroderma 0.4505652610868116 0.6992925020656721 0.4843692518628428 1.0 0.7150872399602058 5 P28340 1 +Breast hypoplasia 0.4503648290404507 0.6983095526051408 0.4849836264962328 1.0 0.7157668134375788 5 Q9Y619 1 +Abdominal pain 0.3218962742559318 0.6972234888636293 0.4856629413729456 1.0 0.7161481270835256 86 Q70HW3,Q13546,P42892,P04062,Q13423,P21912,P49327,Q5HYI8,Q14566,Q9Y4P3,P06280,Q14108,Q9NZ08,P23786 14 +Hypopigmentation of the skin 0.3363241936655662 0.6946133695910932 0.4872976313820225 1.0 0.7172609771801263 49 P49327,P21964,P42345,Q01968,O95613,P07602,Q8IZA0,O00203,Q96C86,P51798,Q6PGP7,Q9NZJ7,P53701,O15360,O14617,P21912 16 +Abnormality of subcutaneous fat tissue 0.427333789722608 0.6890094984513211 0.490817290237584 1.0 0.7202600458604518 14 O75844 1 +Abnormal muscle fiber protein expression 0.4652889908275531 0.688513557186417 0.491129435892967 1.0 0.7204885883039863 7 Q9H9S5,Q9Y5P6,Q9BTV4 3 +Esodeviation 0.3428944288386063 0.6871467595848701 0.4919902505430364 1.0 0.7212958990290147 40 Q9UHX1 1 +Epicanthus 0.280498868458798 0.6865424777370259 0.4923710875951204 1.0 0.7213554534894093 179 Q15392,Q6PJG6,Q9UHX1,Q9Y4P3,P51812,Q13426,O95202,Q9UM00,O75381,Q15555,Q7LGA3,Q9UBM7,P43034,O15360,P21964,P42766,Q9Y2R0,P62266,Q9P2D1,Q9Y487,O75845,Q15067,P62847,O00203,Q03164,P37268 26 +Microcornea 0.3600648512058759 0.6863432789212813 0.4924966634671559 1.0 0.7213554534894093 31 Q9NWM8,O15347,Q96L58,Q15042,Q15555,Q9H9S5,O43505,Q8NAT1,O75845 9 +Involuntary movements 0.2724916980605544 0.684778779999239 0.4934835277298492 1.0 0.7219135949249046 352 P15289,P42858,Q6PJG6,Q9UHX1,Q96CU9,Q96IX5,P55011,Q9Y619,Q9Y4P3,P06280,Q9H9S5,Q9P0J0,Q14108,Q9BQT8,Q99720,Q6DKK2,O95202,P21912,Q13510,Q96RL7,Q9Y287,Q9NR77,O43292,Q9UBX3,P13073,P00374,P50897,P12235,Q9NWS8,P04062,P03886,Q13315,P07602,Q9P2D1,O14949,P51798,P00403,P05067,Q5XKP0,P17900,O14773,Q15907,P27544,Q9NZJ7,O75503,Q03164,Q9NPL8,Q6P4A7 48 +Hypoplasia of the uterus 0.4549640970565933 0.6819876663430444 0.4952467497622881 1.0 0.7231038338766784 10 Q16740 1 +Episodic pain 0.4260468970514681 0.6816750556897764 0.4954444437146439 1.0 0.723165216933156 14 Q13423,P23786 2 +Abnormal arterial physiology 0.360712519391146 0.6802037134564013 0.4963754813706904 1.0 0.7238419605926641 30 Q9NWM8,P05067,P49327,Q9Y4P3,P06280,O75844,Q14739,Q9NZ08 8 +Absent distal phalanges 0.379813302217043 0.6792264548606743 0.4969943875101172 1.0 0.7243177453845641 2 Q6NUK1 1 +Abnormality of facial musculature 0.3206342389152102 0.6788382310978693 0.4972403669769321 1.0 0.7243177453845641 84 Q9UHX1,O75165,P51812,Q9H9S5,Q9BQT8,Q15043,Q13510,O43819,Q9UL01,O75381,P48651,P12235,Q9H5V9,P04062,Q9Y5P6,Q9P2D1,P51798,P10253,Q9BUK6,Q15907,P50570 21 +Abnormal leukocyte physiology 0.3213758774267222 0.6788078562378506 0.4972596152929678 1.0 0.7243177453845641 70 P49327,P21964,P42345,P04062,Q9UJW0,Q96MG7,Q15904,Q13315,O00203,P09601,Q6PGP7,Q14108 12 +Abnormal libido 0.4463063369450405 0.6784561510838066 0.497482517053889 1.0 0.7243180673960639 5 P42858 1 +Interstitial pneumonitis 0.379521586931172 0.6776143682052239 0.498016233576684 1.0 0.7245843661161867 2 P16885 1 +Muscle fiber atrophy 0.3895047821571021 0.6766864589569758 0.4986049097382059 1.0 0.7245843661161867 21 Q99720 1 +Infantile spasms 0.357317223290192 0.6765014481066172 0.498722326941402 1.0 0.7245843661161867 32 Q9UBX3,P03886 2 +Aplasia hypoplasia of the earlobes 0.4329765825266863 0.6712992334564003 0.5020299228912648 1.0 0.7279207573678138 13 O95613,Q13535,Q9P2D1 3 +Retinal degeneration 0.3256811723699275 0.6712547106248951 0.5020582807553886 1.0 0.7279207573678138 63 Q13510,P04062,O14773,P51648,Q7LGA3,O75503,P50897 7 +Abnormality of globe size 0.323802373585134 0.6711116879854009 0.5021493816969098 1.0 0.7279207573678138 66 O75431,O15347,Q9UHX1,Q01968,Q9H9S5,Q8NAT1,Q9UBN7,Q15555,P53701,O15360,P21964,Q96N67,Q9Y5P6,Q15042,Q9P2D1,O75569,P11166,Q13535,Q9BUK6,O43505 20 +Abnormal csf metabolite level 0.3271243828801962 0.666711581196168 0.504956379809733 1.0 0.7303945643200558 59 Q9NWS8,Q9P032,Q96CU9,P03886,P14854,P13073,Q9Y6M9,Q9NPL8,Q9P0J0,P00403,O43676,Q86Y39,Q7KZN9 13 +Abnormal external genitalia 0.2831991864244876 0.6640304602805561 0.5066708157727657 1.0 0.7319628762687405 302 Q15392,P42858,Q13423,Q9UHX1,P01889,P55011,Q9Y619,Q9Y4P3,Q86XL3,Q9H9S5,Q9BPU6,Q13426,Q8NAT1,O95202,P31939,P21912,P42892,Q9UM00,Q9UL01,O95613,O75381,Q15555,Q7LGA3,Q9UBM7,Q9UBX3,Q6PGP7,P48449,P48651,P16435,P43034,O15360,O95470,P27635,P21964,P42766,Q13315,Q9P2D1,O76024,O75844,Q06136,Q9NSD9,Q9Y487,O75845,P49327,P42345,O14678,Q13535,P78527,P62847,Q8TAA9,P51970,P50570,P28340,O43505,Q9NVI7,Q9NZ08,P37268,Q07864,P51571 59 +Anencephaly 0.4049994955629985 0.6623276504413942 0.5077612599149277 1.0 0.7333101689663519 17 Q15427,O43505,Q9P2D1,Q8TAA9 4 +Night sweats 0.3760210035005799 0.6583263110219123 0.5103284747007817 1.0 0.7360927985542606 2 Q9UJS0 1 +Generalized dystonia 0.3993394633708439 0.658090161623404 0.5104801973615642 1.0 0.7360927985542606 3 P04350 1 +Abnormal circulating sulfur amino acid concentration 0.4501927451556407 0.6577291439393942 0.5107121917148243 1.0 0.7361988342249686 10 Q6PGP7,Q99707,O14678,Q9UDR5 4 +Abnormality of the lens 0.2852498336201435 0.6573106696571257 0.5109811773198274 1.0 0.7363581109888084 219 P01889,Q9Y4P3,P06280,P51812,Q9H9S5,Q13426,Q9BQS8,Q8NAT1,Q16134,P21912,Q9Y287,O15228,O75381,Q15555,Q7LGA3,Q9UBM7,P48449,P12235,O15360,P23786,P21964,P42766,Q9Y5P6,Q03519,Q16625,Q14320,P03886,O76024,Q13126,P00403,Q03518,Q06136,Q6ZXV5,O75845,P49327,Q15800,Q96L58,P62847,Q99797,O43505,Q9NVI7,Q9NZ08 42 +Kyphoscoliosis 0.3256932570699619 0.6557974105544836 0.5119544827507543 1.0 0.7373033251270937 60 Q9NWM8,Q96L58,Q9NR77,Q96AY3,O75844,P51812,P10412,Q9Y487,Q8TB36 9 +Gait disturbance 0.2754962667175429 0.6550713686060685 0.5124218051157721 1.0 0.7377476624009535 337 P15289,P42858,Q6PJG6,P01889,Q96CU9,O75165,P55011,Q9Y619,Q9Y4P3,Q8IV08,P51812,Q9H9S5,Q13426,Q14108,Q9BQT8,Q99720,Q9BPU6,P21912,Q13510,Q15043,O43819,Q96RL7,P49902,P16278,Q15041,Q9NR77,Q7LGA3,O43292,P49770,O43681,P12235,Q96N66,P27635,Q96N67,P04062,P13473,O15269,Q9Y5P6,P03886,Q13315,P07602,Q13409,Q9P2D1,Q8WVX9,O75844,O14949,Q5JRX3,P00403,Q8TB36,P05067,O15118,Q15067,P42345,Q5XKP0,P49327,Q9BUK6,O75190,O75569,P11166,P50402,Q96AY3,O14773,Q15907,P50570,Q96C86,Q9NZJ7,O75503,Q03164,Q9NVI7,Q9NZ08,Q9BTV4 71 +Persistent head lag 0.4581701027323748 0.6542622583201262 0.5129428569595409 1.0 0.7382690562063281 7 Q9NSD9 1 +Aphthous ulcer 0.4580497857014055 0.653685910325558 0.5133141825289824 1.0 0.7384987244387162 7 P49327,Q9NZ08,P78527 3 +Abnormal jejunum morphology 0.3751458576429436 0.6535211859262194 0.5134203357591591 1.0 0.7384987244387162 2 O14974 1 +Gastroesophageal reflux 0.2982413200997872 0.652352150281259 0.514174024838433 1.0 0.7391039079295737 131 Q9UHX1,P55011,Q9Y619,Q9Y4P3,O95202,Q9UBM7,P16435,Q14739,P12235,Q96A33,Q9Y584,P21964,O15269,P07602,Q9P2D1,Q6ZXV5,Q01105,Q9NSD9,O14678,P49748,Q8IZA0,Q9NZJ7,Q03164,P51571 24 +Abnormality of the pubic bone 0.4600398843012553 0.6517123748582077 0.5145867379948452 1.0 0.7391039079295737 6 O95202 1 +Abnormality of the knee 0.3158996915549429 0.6516357662068811 0.5146361690617915 1.0 0.7391039079295737 96 Q13510,P21964,P21912,P49902,P16278,Q15041,Q96L58,Q9Y619,Q86XL3,Q9Y4P3,Q9NR77,Q7LGA3,Q96AY3,P51798,P48651,Q96HY6,P37268,P23786 18 +Deviation of toes 0.3337989768216827 0.6506084237012665 0.5152992912612886 1.0 0.739733234041219 47 P42858,P04062,Q96L58,Q7LGA3,P51812,Q15427 6 +Abnormal ureter physiology 0.3306590109883886 0.6502620179366121 0.5155229869228695 1.0 0.739733234041219 50 P21964,Q9UHX1,Q9Y4P3,Q86XL3,Q9UBM7,Q9P2D1,Q8TAA9,P42695,P16435,P21912 10 +Abnormality of the phalanges of the toes 0.3883059479655736 0.6483466498022478 0.5167607680231074 1.0 0.7409963904557192 20 O75844,Q7LGA3 2 +Abnormal labia morphology 0.3932934878246986 0.6481140749095541 0.516911171215451 1.0 0.7409963904557192 19 Q9Y619,P31939,P16435 3 +Skin dimple 0.3748337705605009 0.6466283232807571 0.5178725225451171 1.0 0.7421455088663214 24 P27635,Q9UM00,Q9Y4P3,Q8TAA9,Q03164,P43034,O95202 7 +Ecchymosis 0.4363574267624533 0.6445453293850019 0.5192218733594489 1.0 0.7433913169885977 12 P04062 1 +Parietal bossing 0.3728121353558934 0.6407418376628267 0.5216904270404421 1.0 0.745309703017343 2 O14802 1 +External ear malformation 0.4013266776616271 0.6399045921156626 0.5222346282851729 1.0 0.745309703017343 17 Q9UL01,O75381,Q9P2D1,Q15555,P40855,O15360 6 +Leukodystrophy 0.3220900911374822 0.6384397084084786 0.5231874894522599 1.0 0.7463092035600858 64 P15289,Q15067,Q7KZN9,Q9P032,Q96CU9,P03886,P14854,P07602,Q9NZJ7,Q9NPL8,Q9P0J0,O43681,O43676,Q86Y39,P21912 15 +Reticulocytopenia 0.3864894286756732 0.6364900004080019 0.5244570965122886 1.0 0.7472025974842357 20 P42766,P62847 2 +Cessation of head growth 0.4541661170483816 0.6351301307224088 0.5253435472339414 1.0 0.7480067791752656 7 P49770 1 +Pleural effusion 0.4262221485833952 0.6342539660464597 0.5259150936452781 1.0 0.7483618759803865 13 Q14739,P49327,Q9NZ08 3 +Agenesis of corpus callosum 0.3154747906156541 0.6324507612845995 0.5270923733746082 1.0 0.7485043849212382 92 Q15392,Q9Y5P6,Q9UHX1,P55011,P03886,Q86XL3,Q13409,Q7LGA3,Q9H9S5,Q9BPU6,P00403,O43505,Q8NAT1,P48651,O95202,P42695,Q96SN8,P23786 18 +Telecanthus 0.3335895971309022 0.6323344898584091 0.5271683310110307 1.0 0.7485043849212382 45 Q86XL3,O75844,P51812,Q03164,Q13426 5 +Hypoplastic heart 0.3942223519113086 0.631390519688772 0.5277852132088188 1.0 0.7485043849212382 3 Q12768,O60826 2 +Solitary median maxillary central incisor 0.3942223519113058 0.6313905196887565 0.527785213208829 1.0 0.7485043849212382 3 Q14683,A5YKK6 2 +Aplasia hypoplasia of the optic nerve 0.372393901283623 0.6294674513527064 0.5290430711200655 1.0 0.7494843288525912 24 Q9NVI7,Q96KP1,P37268,Q9UHX1 4 +Decreased proportion of cd4 positive helper t cells 0.4444942201830403 0.6289404012759324 0.5293880749148296 1.0 0.7494843288525912 10 Q96MG7,Q13315,Q13432 3 +Abnormality of the tarsal bones 0.3647123396183326 0.6284210415637869 0.5297281565342411 1.0 0.7494843288525912 26 Q14739,O75844,Q9UHX1,P16435 4 +Emg abnormality 0.3166254628468357 0.6279006401979678 0.5300690315852159 1.0 0.7496805847016479 78 P15289,Q9H9S5,P42167,Q13510,O43819,Q96RL7,Q9Y6B6,Q9NR77,O43681,P12235,Q9Y5P6,P13473,O15269,P07602,Q8TB36,Q9BUK6,P50402,O14773,P50570,Q9NZJ7,Q9BTV4 21 +T lymphocytopenia 0.4250114573577817 0.6276470336371199 0.5302351901835101 1.0 0.7496873687135082 13 Q96MG7,P49327,Q13315,Q13432 4 +Enamel hypoplasia 0.3992244435910329 0.6271164760033959 0.5305828878402377 1.0 0.7499507444191494 17 P18074,Q13535,O95613,Q01968,P51648 5 +Abnormality of the forearm 0.3238729472266219 0.6260874574440013 0.5312575785514273 1.0 0.7504477683034149 57 Q13535,O95613,Q96L58,Q9Y4P3,O15360,Q96AY3,Q9UBM7,Q9P2D1,P16435,O95202,Q15427 11 +Abnormally large globe 0.445664281407007 0.6197772608837988 0.5354044413518588 1.0 0.7551575696784262 9 Q01968,Q9H9S5,Q13535 3 +Abnormal platelet volume 0.4454474720316097 0.6187096036273094 0.5361076822122215 1.0 0.7556906224387078 9 Q14739,Q6PGP7 2 +Olivopontocerebellar hypoplasia 0.4336916343029477 0.6174140556587145 0.5369616533681092 1.0 0.7566647987710753 5 Q9H9S5 1 +Myalgia 0.334404111592259 0.6157381544329755 0.5380673511295058 1.0 0.7573041240071747 41 P49327,P21964,P01889,Q9BUK6,P49748,P14854,P06280,Q9NZ08,P50570,Q9H9S5,Q14739,P12235,P23786 13 +Abnormality of skeletal maturation 0.3119705273753657 0.6143939249137036 0.5389550492792434 1.0 0.7580942049504586 99 P04062,Q15800,Q13535,Q9Y619,Q9Y4P3,Q9P2D1,P13073,P51812,Q03164,P48449,Q14108,P10412,O95202,P16435 14 +Paresthesia 0.3665158853343293 0.6137648643226166 0.5393707183609067 1.0 0.7581896523161064 25 P49327,P05067,P01889,Q9NR77,P06280,Q9NZ08,P54802 7 +Abnormal ureter morphology 0.3586867147164553 0.6134926296265253 0.5395506546922217 1.0 0.7581896523161064 27 Q8TAA9,Q7LGA3,O75844,O15360,P23786 5 +Aplasia hypoplasia of the tongue 0.4327836181309712 0.6130627497794835 0.5398348494086238 1.0 0.7581896523161064 5 Q9UBM7 1 +Congenital malformation of the right heart 0.4412073887043497 0.6124334558619865 0.5402510123806721 1.0 0.7582655663134868 10 Q86Y56,P01889,Q9P2D1 3 +Hypopigmented macule 0.4138937536485763 0.6117892408339772 0.5406772091118532 1.0 0.7584499738930164 4 Q15149,Q15233,P21359 3 +Tremor 0.2761155009422032 0.6110429953784039 0.5411711166713191 1.0 0.7586846735229176 178 P15289,P42858,Q9Y4P3,Q14108,Q6DKK2,Q99720,P21912,Q13510,Q96RL7,Q9Y287,Q9NR77,O43292,P12235,P04062,P03886,Q13315,P07602,Q9P2D1,P51798,O14773,Q9NZJ7,O75503,Q6P4A7 23 +Abnormal respiratory motile cilium physiology 0.3895535453749701 0.6072267535010328 0.5437004398653116 1.0 0.7594805302508231 3 Q9NVR5,Q86Y56 2 +Abnormal respiratory motile cilium morphology 0.3895535453749701 0.6072267535010328 0.5437004398653116 1.0 0.7594805302508231 3 Q9NVR5,Q86Y56 2 +Nasal congestion 0.3895535453749701 0.6072267535010328 0.5437004398653116 1.0 0.7594805302508231 3 Q9NVR5,Q86Y56 2 +Wheezing 0.3895535453749701 0.6072267535010328 0.5437004398653116 1.0 0.7594805302508231 3 Q9NVR5,Q86Y56 2 +Abnormal atrial arrangement 0.3895535453749701 0.6072267535010328 0.5437004398653116 1.0 0.7594805302508231 3 Q9NVR5,Q86Y56 2 +Cutis marmorata 0.3867433536809059 0.6064791877284114 0.5441965984784689 1.0 0.7594885540795935 19 Q5T2R2,P51812,P48651,Q9UBM7 4 +Impaired proprioception 0.3398970206418739 0.604693864313732 0.5453824257216198 1.0 0.7602300075886127 37 Q96RL7,Q9Y6B6,Q9Y619,O14773,Q8IV08,P54802 6 +Ectopic anus 0.3997160910396822 0.6046549602735211 0.5454082803900502 1.0 0.7602300075886127 16 P49748,P16435 2 +Decreased circulating iga level 0.428744287115792 0.6043299115736633 0.5456243235298066 1.0 0.7602300075886127 12 P42345,Q15904,Q13315,P50851 4 +Abnormality of the calf musculature 0.3910238908083763 0.6042015374221451 0.545709658912618 1.0 0.7602300075886127 18 Q96RL7,Q9NR77,P50570,Q9H9S5,Q8NAT1 5 +Neoplasm of the colon 0.335612610055186 0.6027833133106246 0.5466528489461888 1.0 0.7610574460642257 39 P42766,Q5HYI8,P62847,P28340,P21912 5 +T cell lymphoma 0.4305370452603865 0.6023234580011858 0.5469588489901958 1.0 0.7610574460642257 5 P49327,Q07864 2 +Abnormality of retinal pigmentation 0.3141351031520148 0.599655155922967 0.5487360803342187 1.0 0.7623887049141088 76 Q15067,Q7KZN9,Q16836,Q9BUK6,Q96CU9,P03886,O75381,Q15555,P51648,O76024,P51812,Q9H9S5,Q9P0J0,P00403,Q13432,P21912 16 +Abnormal renal tubule morphology 0.3606763667037855 0.5989866012878101 0.5491818195213898 1.0 0.7626227931068568 26 P03886,Q9Y4P3,P23786 3 +Progressive cerebellar ataxia 0.3372423400035133 0.5989100644451832 0.5492328596073057 1.0 0.7626227931068568 38 P42858,Q96CU9,O14773,Q9P0J0,Q9Y487,Q7KZN9 6 +Arthralgia 0.3410193446132484 0.5982750705251167 0.5496564078957102 1.0 0.7627549794156123 36 Q13510,P49327,Q15800,P01889,Q9Y4P3,P06280,Q96HY6,Q9NZ08 8 +Muscle weakness 0.2802736996734677 0.5953053079481547 0.5516394085013927 1.0 0.7641134416171228 300 P15289,P42858,Q9P032,Q9UHX1,P01889,Q15165,Q96CU9,P14854,P51812,Q9H9S5,Q9P0J0,Q9BQT8,Q8NAT1,Q99720,O43676,O43772,Q16134,Q6DKK2,P21912,Q13510,Q15043,O43819,Q96RL7,Q9UL01,Q9NR77,O75381,P13073,P00374,P48651,P43034,Q14739,P12235,O43681,Q86Y39,P23786,P47985,Q9NWM8,Q9H5V9,P13473,O15269,P03886,P07602,Q9P2D1,P51798,Q13126,Q9Y6M9,P00403,Q8TB36,P10253,Q70HW3,Q15067,Q5XKP0,Q9BUK6,P17900,P49748,P51970,P50570,Q9NZJ7,Q9NPL8,O43505,Q9BTV4 61 +Spondyloepimetaphyseal dysplasia 0.4432403234843454 0.5948390256284676 0.5519510783613999 1.0 0.7641134416171228 8 Q96L58 1 +Amblyopia 0.3978721827585291 0.5937680213840254 0.5526672804049766 1.0 0.7645877216790143 16 P10412,Q9UHX1 2 +Abnormal systemic blood pressure 0.3119345292983978 0.5912974651561143 0.554321127712389 1.0 0.7659846809134263 93 P15289,P42892,P04062,Q13423,O43681,P03886,Q9Y4P3,P07602,P06280,Q8TAA9,O75844,Q9NZJ7,P00403,P16435,O43772,Q9NSD9,P21912 17 +Infantile muscular hypotonia 0.3130517992994071 0.5902552560863251 0.5550195319755837 1.0 0.7663510511583639 73 Q13510,P16278,P17900,P49748,P03886,P07602,Q9H9S5,Q9NZJ7,Q2TAA5,Q9Y487,P10253 11 +Abnormal liver physiology 0.4466396080059914 0.5892767277828045 0.555675653728414 1.0 0.7665288263723905 6 Q13510 1 +Abnormality of the pharynx 0.3217508389467995 0.5852936700746536 0.5583502703594716 1.0 0.7688486532572926 52 Q13510,Q03519,Q13277,P16278,Q03518,P54802,Q13432 7 +Aplasia hypoplasia of the patella 0.4453838905492401 0.5834896759635718 0.55956370502081 1.0 0.769708065564676 6 Q9Y619,Q96AY3 2 +Facial asymmetry 0.3333876342305421 0.5833374920113644 0.5596661281893973 1.0 0.769708065564676 39 Q13535,Q9UHX1,O15360,Q03164,O95202 5 +Diplopia 0.3754102686307797 0.5832376148598959 0.5597333526654071 1.0 0.769708065564676 21 P04062 1 +Abnormal qt interval 0.4353350130243149 0.583134522879409 0.5598027450587688 1.0 0.769708065564676 10 P49748,P0DP25,Q16836 3 +Hyperthyroidism 0.4379165577594887 0.5818324390636027 0.5606795515269818 1.0 0.7701483411046469 9 P12235,P21964 2 +Skin ulcer 0.3424027463202434 0.5813160691768885 0.5610274524296837 1.0 0.7701483411046469 34 Q03519,P04062,O15269,Q8IZA0,Q03518,Q14739 6 +Polyhydramnios 0.3197079386830177 0.5808716107210282 0.5613269871098647 1.0 0.7701483411046469 56 Q70HW3,P21964,P04062,Q9UM00,P43034,Q9UBM7,Q9P2D1,O75844,P51798,Q6PGP7,P50570,Q14739,Q9NVI7 13 +Abnormality of skin pigmentation 0.2911462373842102 0.5806228840628902 0.5614946456644347 1.0 0.7701483411046469 141 P42858,Q13423,P55011,P21912,O95613,Q7LGA3,Q6PGP7,Q14739,O15360,P21964,P04062,P03886,Q13315,P07602,P51648,O75844,P51798,P00403,Q06136,P49327,P42345,Q96AY3,Q8IZA0,Q9NZJ7,P16615 25 +Abnormal cerebral vascular morphology 0.3121946804415644 0.5803667043697582 0.5616673533811669 1.0 0.7701483411046469 73 P05067,P04062,P10253,O95613,P03886,Q9Y4P3,Q96L58,P06280,O76024,P38435,O75844,P00403,Q9NSD9,P23786,P21912 15 +Abnormality of taste sensation 0.384301138021611 0.5802851224029129 0.561722358585627 1.0 0.7701483411046469 3 Q12756,O95163 2 +Respiratory tract infection 0.2759689454650981 0.5799529025015275 0.561946378894695 1.0 0.7701483411046469 173 Q13277,Q9Y4P3,P09601,O95202,Q13510,P16278,P04062,Q03519,Q13315,P07602,Q9P2D1,Q8N5M9,P51798,Q03518,Q9Y487,P10253,P49748,Q9NZJ7,Q9NPL8,P54802,Q13432 21 +Abnormal tendon morphology 0.2815265794987143 0.5796166385393072 0.5621731701258004 1.0 0.7702319517559624 223 Q15392,Q6PJG6,Q9P032,Q9Y619,Q86XL3,Q9H9S5,P10412,Q99720,P21912,Q13510,Q15043,P42892,P49902,Q15041,Q9NR77,O15228,Q7LGA3,P50897,P48449,P16435,Q96A33,P23786,P04062,Q9P2D1,O75844,Q8TB36,Q13535,Q96L58,Q96AY3,Q8IZA0,P28340,Q96KP1,Q9BT22,P37268 34 +Antinuclear antibody positivity 0.4421091991495174 0.5781656077178097 0.5631523159826914 1.0 0.771346008271104 7 P49327 1 +Chronic otitis media 0.3484835594333422 0.5756731223727938 0.5648361457812614 1.0 0.7717166490461002 29 O95202,Q03519,Q03518 3 +Premature ventricular contraction 0.4436011377604311 0.5752939514770885 0.5650925114985839 1.0 0.7717166490461002 6 O43772 1 +Feeding difficulties 0.2622873636176098 0.5741070415633264 0.5658953686266206 1.0 0.7717166490461002 369 P15289,Q15392,P42858,Q13277,Q6PJG6,Q9UHX1,Q96CU9,Q96MG7,Q9P032,Q9Y619,P55011,P14854,P51812,Q9H9S5,Q99720,O43676,Q2TAA5,P21912,Q13510,P16278,Q7LGA3,Q9UBM7,P00374,O43681,Q86Y39,Q96N66,Q9Y584,P23786,P47985,Q96A33,Q9NWS8,P21964,P04062,P03886,P07602,Q9P2D1,O76024,Q9Y6M9,Q9NSD9,Q9Y487,P10253,P42345,O14678,Q16836,Q5XKP0,P49748,P22695,Q15907,Q9NZJ7,Q03164,Q99797,Q9NPL8,Q9NVI7,P37268,Q07864,P51571 56 +Decreased absent ankle reflexes 0.4150952621921837 0.5739550131793762 0.565998244183942 1.0 0.7717166490461002 13 P12235,Q96RL7,Q15041 3 +Abnormal circulating protein concentration 0.2859781073761309 0.57335483147752 0.5664044667079424 1.0 0.7717166490461002 154 P53985,Q15120,Q9Y4P3,Q9H9S5,O43772,Q8NAT1,P42167,Q8N511,Q96RL7,Q9Y6B6,Q6PGP7,P12235,Q9Y584,P47985,O95470,P23786,Q9NWM8,Q9Y5P6,P13473,Q13315,Q5JRX3,Q6ZXV5,Q9NSD9,Q9Y487,P10253,O75190,Q16836,Q5XKP0,Q9BUK6,P49748,P50402,P50570,Q9BT22,O43505,Q9BTV4 35 +Abnormal femoral head morphology 0.3708801551797184 0.5732595365468757 0.566468978285136 1.0 0.7717166490461002 22 O75431,O95831,P16278,Q6NUQ1,O95613,Q96L58,Q7LGA3,Q99575 8 +Increased susceptibility to fractures 0.3181663934782194 0.5728033238578485 0.5667778682941385 1.0 0.7717614232399084 59 P04062,O15269,Q96L58,Q96AY3,Q9P2D1,P51798,Q13126,Q14108,P16435,Q14739 10 +Abnormal conjugate eye movement 0.2738154089518639 0.5672470856346783 0.5705463218227298 1.0 0.774577046608805 328 Q15392,P42858,Q9P032,Q9UHX1,Q96CU9,P51571,P55011,Q9Y619,Q9Y4P3,P38435,P51812,Q9H9S5,Q9P0J0,P10412,Q99720,O43676,O95202,Q9H061,Q2TAA5,Q96RL7,Q92974,Q7LGA3,P16435,Q14739,P12235,O15360,Q86Y39,O95470,P42766,P04062,P03886,Q13315,P07602,Q9P2D1,Q9Y487,Q15067,O15118,P42345,Q13535,P62847,Q15907,Q9NZJ7,Q03164,Q9BT22,Q9NPL8,Q9NVI7,Q7KZN9 47 +Abnormal t wave 0.4229709420870967 0.5664475282999508 0.5710895931828517 1.0 0.774577046608805 5 P0DP25 1 +Head tremor 0.4050628397111751 0.5637486293136615 0.5729252170914889 1.0 0.7764908280650692 14 Q99720 1 +Abnormal carotid artery morphology 0.3885966327315724 0.5630433121205504 0.5734053911904131 1.0 0.7768810399178064 17 O75844,Q9Y4P3 2 +Respiratory insufficiency 0.2734254723657875 0.5621996996434735 0.5739799660463949 1.0 0.777240140557141 178 Q9P032,Q96CU9,Q15165,Q9Y619,P06280,O43772,O43676,Q13510,Q9NR77,Q14739,P12235,Q86Y39,P23786,P13473,P03886,P07602,Q9P2D1,Q15427,Q9NSD9,P10253,Q70HW3,Q15067,Q5XKP0,P49748,Q96L58,Q96AY3,Q9NZJ7,Q9BT22,Q9NPL8 29 +Abnormal cardiac ventricle morphology 0.2774835835678904 0.5611696373091364 0.574681899344003 1.0 0.7779638998695333 199 Q9UHX1,Q96CU9,P55011,Q9Y4P3,P14854,P06280,Q9P0J0,O43772,O95202,P21912,P42892,P0DP25,Q6PGP7,Q14739,P12235,P47985,P23786,P42766,P03886,Q99959,Q9P2D1,O75844,P00403,Q15427,P10253,P49748,Q96L58,P62847,Q96KP1,Q7KZN9 30 +Broad distal phalanx of finger 0.4379842792184196 0.5589223190169891 0.5762147365318349 1.0 0.7795846435430708 7 Q7LGA3 1 +Neonatal insulin dependent diabetes mellitus 0.3796323314852747 0.5565689840862176 0.5778219498549122 1.0 0.780831782189411 3 A5YKK6,O00330 2 +Missing ribs 0.390971797182315 0.55330153986459 0.5800569468033798 1.0 0.7820484450563674 16 Q14739,Q96L58,Q13535,Q8TAA9 4 +Tetraparesis 0.3294627910919843 0.5491684659479219 0.5828898429381066 1.0 0.7835311240536211 39 P17900,Q9UBX3,Q9NZJ7,P07602 4 +Lower limb pain 0.4192541666967352 0.5489995811150277 0.5830057372920816 1.0 0.7835311240536211 5 Q8WVX9 1 +Constitutional symptom 0.281296636106604 0.548761551668178 0.5831690992108354 1.0 0.7835311240536211 258 P15289,Q13546,Q13423,Q15165,Q5HYI8,Q9Y4P3,P14854,O43572,P06280,P51812,Q9H9S5,Q14108,Q99720,Q96HY6,P21912,Q13510,Q15043,P42892,Q9NR77,P0DP25,Q14739,O43681,P12235,P23786,Q14566,P21964,P04062,O15269,Q13315,P07602,Q99959,O75844,P51798,Q70HW3,P49327,Q15800,Q9BUK6,P49748,Q8TAA9,P50570,Q9NZJ7,Q9NZ08,Q9BTV4,Q07864 44 +Deviation of the hallux 0.3366922720767639 0.5479150713741169 0.5837502196876745 1.0 0.7835311240536211 35 P42858,P04062,Q96L58,Q7LGA3,Q15427 5 +Neoplasm of the large intestine 0.3242745861730647 0.5459748629751248 0.5850832163380335 1.0 0.784501189929727 45 P42766,Q5HYI8,P62847,Q07812,P28340,Q07864,P21912 7 +Abnormality of dna repair 0.4369959861007272 0.54514428589439 0.5856542863069913 1.0 0.7846394047102866 6 O15360,P18074 2 +Large basal ganglia 0.3813489824300722 0.5448425125808185 0.5858618370512234 1.0 0.7846394047102866 18 Q13535,P55011,Q2M389,Q96C86,Q9NZ01,Q96N66 6 +Weakness of facial musculature 0.3142555389097005 0.543302253210654 0.5869217131605298 1.0 0.7853796887511005 62 Q13510,O43819,Q9H5V9,Q9Y5P6,Q9UHX1,Q9BUK6,O75381,Q9P2D1,P50570,P51798,P51812,Q9H9S5,Q9BQT8,P48651,P12235,Q15043 16 +Hammertoe 0.3765182875511613 0.5422695655895268 0.5876328183523643 1.0 0.7854232016872191 19 Q99720,Q9NR77,Q8TB36 3 +Tissue ischemia 0.369131646690821 0.5422069144603983 0.5876759725285896 1.0 0.7854232016872191 21 P49327,P05067,Q9Y4P3,P06280,O75844,Q9NZ08 6 +Babinski sign 0.30885292514731 0.5417822034968909 0.587968552619059 1.0 0.7854232016872191 88 Q6DKK2,Q15067,P42858,P15289,P49902,Q6PJG6,Q15043,Q9NR77,P07602,O14773,P51812,Q9NZJ7,Q99720,P21912 14 +Otitis media 0.3143748729526192 0.540296810466291 0.5889923576536504 1.0 0.7863386476031207 61 P21964,Q03519,Q9Y4P3,Q9UBM7,Q8N5M9,P51798,Q03518,Q14739,O95202,Q13432,Q96A33 11 +Sparse or absent eyelashes 0.3485902776589497 0.5388240707153172 0.5900082529520139 1.0 0.7874686421186603 27 O75844,Q15427 2 +Movement abnormality of the tongue 0.3987388760929975 0.5380193982377371 0.5905636565097654 1.0 0.787983557766907 4 P10253 1 +Premature loss of teeth 0.41591812082009 0.5376001249770281 0.5908531439330513 1.0 0.7880849045526095 12 O75844 1 +Neoplasm of fatty tissue 0.4311034159007688 0.5371956185870207 0.5911324974148848 1.0 0.7880849045526095 8 P21912,Q9BUK6,Q8TAA9 3 +Abnormal involuntary eye movements 0.2754164588121157 0.5356125285757495 0.5922263681602695 1.0 0.7888428057547627 313 Q15392,P42858,Q13277,Q6PJG6,Q9P032,Q96CU9,Q9Y4P3,Q8IV08,Q13426,Q9P0J0,Q99720,O43676,O95202,Q9H061,O43772,Q6DKK2,P21912,Q13510,P49902,Q9NR77,Q7LGA3,O43292,P12235,O15360,Q86Y39,Q16625,P04062,P03886,Q13315,P07602,Q9P2D1,P51798,Q15067,Q5XKP0,P17900,O14773,Q15907,Q9NZJ7,O75503,Q9BT22,Q9NPL8,Q9NVI7,Q7KZN9 43 +Gingival overgrowth 0.3420025904143942 0.5346459268629401 0.592894719174411 1.0 0.7894058983616563 30 P16278,Q9Y4P3,Q9UBM7,Q14739,O75845 5 +Abnormality of the nasal tip 0.3029990005277878 0.5345097096354527 0.5929889335519114 1.0 0.7894058983616563 106 P42892,P16278,Q9UHX1,Q7LGA3,O75844,P51812,Q13426,Q9Y487,P23786 9 +Periorbital fullness 0.3648111687765036 0.5329267068833977 0.5940843170507191 1.0 0.7906375643132744 22 Q96N67,P51812,P62266,Q7LGA3 4 +Diarrhea 0.3085305394090025 0.5323866155352086 0.594458253315493 1.0 0.7909086611981043 79 Q13546,Q13277,Q13423,Q5HYI8,P06280,Q13510,P42892,Q9Y6B6,Q15904,Q6PGP7,Q14691,Q96A33,Q14566,P03886,Q9P2D1,P00403,Q16836,Q9BT22,P54802 19 +Abnormal vitamin b12 level 0.4319055410833951 0.5308165252758944 0.5955459274192274 1.0 0.7916756448611532 7 O14678 1 +Zonular cataract 0.4270986887715227 0.5296358416163741 0.5963644390650487 1.0 0.7925369519153936 9 O76024,P11166,Q99797 3 +Abnormal delivery 0.3642285948656672 0.5290768761949072 0.5967521217466252 1.0 0.7925987300271071 22 O75844,Q9Y619,Q9Y487,Q9UBM7 4 +Acute coronary syndrome 0.3740919723298625 0.5271926927561761 0.5980597825613536 1.0 0.7930696117464411 19 P49327,Q9Y4P3,P06280,O75844,Q9NZ08 5 +Abnormality of the ankles 0.3248638041336216 0.5270903496641964 0.5981308479465195 1.0 0.7930696117464411 40 P42858,P49902,Q9Y4P3,Q96AY3,P07602,O75844,Q9NZJ7 7 +Atresia of the external auditory canal 0.3895669188224371 0.5238315929464451 0.6003956773976369 1.0 0.7953915931535276 15 Q9Y619,Q15427 2 +Severe hearing impairment 0.3729209220893007 0.522891490700598 0.601049766517066 1.0 0.7955775541989485 3 P21281,P04049 2 +Synovitis 0.3729209220892995 0.5228914907005917 0.6010497665170704 1.0 0.7955775541989485 3 O14802,Q02750 2 +Prominent nasal bridge 0.3142044367074496 0.522022241864849 0.6016548445727787 1.0 0.7960645011613093 53 Q15427,P42892,P31939,Q13426 4 +Abnormality of acid base homeostasis 0.2720180485635681 0.5203890232961543 0.6027924591120111 1.0 0.7968578008659416 182 Q13277,Q9P032,Q96CU9,Q9Y619,Q9P0J0,O43676,P21912,Q9UBX3,P13073,P12235,Q86Y39,Q9Y584,P47985,P23786,Q9NWS8,P03886,O14949,P00403,Q70HW3,O14678,Q16836,Q5XKP0,P49748,P22695,Q9NPL8,Q99797,Q6P4A7,Q9NVI7,Q7KZN9 29 +Skeletal muscle hypertrophy 0.31999759553185 0.5202712197629896 0.6028745523124805 1.0 0.7968578008659416 47 Q9Y5P6,P16278,P10253,Q9Y4P3,Q9NR77,Q9Y5W7,Q7LGA3,P50570,Q9H9S5,Q99575,Q8NAT1,Q96A33,P21912 13 +Fasciculations 0.3313398406970513 0.5175796705374528 0.6047515688460705 1.0 0.798203349107626 36 Q13510,Q9NWS8,P07602,P06280,Q9NZJ7 5 +Congenital malformation of the left heart 0.3943374197314708 0.5170084395863338 0.605150267414341 1.0 0.7985027385421835 4 Q12768,O14802,O60826 3 +Type ii diabetes mellitus 0.3235633455155564 0.5156873756375793 0.6060727732722035 1.0 0.7994929314658313 40 O95613,P03886,Q9Y4P3,Q13315,Q13426,P00403 6 +Dental malocclusion 0.3414959563788869 0.5151961413529852 0.6064159651525931 1.0 0.7996066407971044 28 P51812,Q9Y4P3,Q13535 3 +Myopathy 0.3030544048193598 0.513589208940263 0.6075392257280048 1.0 0.8005182197198838 102 Q9P032,Q9Y4P3,Q9H9S5,O43676,P42167,P21912,Q96RL7,Q9UL01,Q9Y6B6,P12235,Q86Y39,P23786,Q9NWM8,Q9NWS8,Q9Y5P6,P13473,P03886,O76024,Q13126,P00403,O75190,Q9BUK6,P50570,Q9BTV4 24 +Tongue fasciculations 0.4033828529911479 0.5116392007834127 0.6089035447574174 1.0 0.8011843055421005 13 Q13510,Q9NWS8 2 +Abnormality of humoral immunity 0.3098482993519664 0.511387971219881 0.6090794160944251 1.0 0.8011843055421005 65 P49327,P42345,P04062,Q9UJW0,Q96MG7,Q15904,Q13315,P09601,Q6PGP7,Q14108 10 +Rapidly progressive 0.4203934345277157 0.5098471209266696 0.6101585705657011 1.0 0.8020873300754572 10 Q14108 1 +Myelomeningocele 0.3927375546202453 0.5094219719830801 0.6104564785077091 1.0 0.8020873300754572 4 Q8TAA9 1 +Abnormal renal cortex morphology 0.3124098011755026 0.5081241812281024 0.6113662579983359 1.0 0.8021484424344164 57 O95470,P49327,P01889,P03886,P06280,Q6PGP7,P00403,Q14108,Q9NZ08,Q16134,P21912 11 +Micropenis 0.3054093653997434 0.5060772368424645 0.6128024297830488 1.0 0.8038057845206225 71 Q9Y619,Q9H9S5,Q13426,Q9BPU6,P42892,Q7Z6Z7,Q9UBM7,P48449,P16435,P53701,O95470,Q9Y5P6,Q5TBB1,Q9P2D1,P46977,P78527,Q96T60,O43505,Q8IWS0,Q9NVI7,Q07864 21 +Abnormality of the kidney 0.2636945448728969 0.5047770588111735 0.6137154305998715 1.0 0.8045490661870777 356 Q15392,Q13277,Q9P032,Q9UHX1,Q96CU9,Q9Y4P3,Q86XL3,P06280,P09601,Q9H9S5,Q13426,Q14108,O43772,O43676,O95202,P21912,Q7LGA3,Q9UBM7,Q6PGP7,P42695,P16435,O15360,Q86Y39,P23786,O95470,Q9NWS8,P42766,P04062,Q16625,P21964,P03886,Q9P2D1,O76024,Q9Y6M9,P00403,Q96SN8,Q15427,O14965,O75845,Q96L58,P62847,Q8TAA9,Q07812,Q92733,Q9BT22,Q03164,Q9NPL8,O43505,Q9NZ08,Q07864,P51571 51 +Abnormal circulating fatty acid concentration 0.3657591677724668 0.5033839238958587 0.6146943720525835 1.0 0.8053779054022286 20 O43772,P49748,P23786 3 +Developmental regression 0.2880155929029969 0.5016376494868278 0.6159224307361089 1.0 0.8057471147815393 132 P15289,P42858,P01889,Q96IX5,Q9Y4P3,P06280,P21912,Q13510,Q15043,O43819,P16278,O75381,P13073,P49770,O43681,O95470,P03886,P07602,O76024,Q15067,P49327,P17900,O14773,Q9NZJ7,O75503,Q9NZ08 26 +Aplasia hypoplasia involving bones of the lower limbs 0.3037445698036269 0.5015036137646515 0.6160167351924295 1.0 0.8057471147815393 97 Q13510,P42858,Q13535,Q9UHX1,P55011,Q96L58,Q9Y619,Q96AY3,O00116,Q9UBN7,Q7LGA3,Q9P2D1,P13073,Q03164,Q96HY6,O95202,Q15427,Q96A33 18 +Glaucoma 0.3044388057394741 0.5006836609866165 0.6165937730991105 1.0 0.8060480218960233 94 Q9Y4P3,Q86XL3,Q9H9S5,Q8NAT1,Q9UL01,O95613,O75381,Q15555,Q9UBM7,Q6PGP7,P12235,P21964,P42766,Q9Y5P6,O76024,Q06136,P49327,Q13535,Q96L58,P62847,O43505 21 +Aplasia hypoplasia involving the skeleton 0.2708434462629496 0.5003242692591925 0.6168467680395118 1.0 0.8061519224505125 328 Q15392,P42858,Q6PJG6,Q9UHX1,P55011,Q9Y619,Q9Y4P3,Q86XL3,P38435,P51812,Q9H9S5,Q13426,Q96HY6,O95202,Q13510,P16278,O95613,O15228,Q9UBN7,Q7LGA3,Q9UBM7,P13073,P16435,Q14739,O15360,Q96A33,P42766,P04062,Q16625,O00116,Q9P2D1,O75844,P51798,Q15427,P42345,O14678,Q13535,Q96L58,Q96AY3,P62847,Q8TAA9,P28340,Q9BT22,Q03164,Q9NVI7,P37268,Q07864,P51571 48 +Abnormal t cell morphology 0.3696712254576557 0.4998977117839556 0.6171471035620997 1.0 0.8063176161837781 19 P49327,Q96MG7,Q13315,O00203,Q13432 5 +Abnormal immune system morphology 0.2720516194573318 0.4987258986600868 0.6179724968388058 1.0 0.8071690245468349 172 Q13546,Q96MG7,Q5HYI8,Q13426,Q14108,P42167,Q13510,P16278,Q15904,Q6PGP7,Q14691,Q14739,O15360,O95470,P42766,P04062,Q13315,Q9P2D1,Q8N5M9,P51798,P49327,O15118,O14678,P62847,Q8TAA9,Q07812,O00203,Q13432 28 +Cleft soft palate 0.3105583093997524 0.4966300974876348 0.6194499248064909 1.0 0.8079293940783332 60 Q9NWM8,Q15392,P42766,Q9Y619,P62847,Q6PGP7,Q9H9S5,P48651,O43505 9 +Brain imaging abnormality 0.3233487442559263 0.4963268095836249 0.6196638541413777 1.0 0.8079293940783332 39 P03886,P07602,Q9NZJ7,P00403,P21912 5 +Abnormal shape of the frontal region 0.2914647422256692 0.4957095571378341 0.6200993432150801 1.0 0.8079293940783332 121 Q15392,Q9Y619,P51812,O95202,P31939,P16278,Q9UBN7,P13073,Q6PGP7,P16435,Q14739,O15360,P51798,Q9Y487,Q15067,P42345,Q96L58,Q9NVI7,Q07864 19 +Subarachnoid hemorrhage 0.3453908984830825 0.4950152474148372 0.6205893576379466 1.0 0.8079293940783332 2 Q6YHK3 1 +Abnormal venous morphology 0.3387776641903183 0.4949651453443328 0.62062472407748 1.0 0.8079293940783332 28 Q9Y487,P04062,P48651,P47985 4 +Recurrent mycobacterial infections 0.3896672504378344 0.4949415025041221 0.6206414135741645 1.0 0.8079293940783332 4 P42224,Q9NVR5,Q86Y56 3 +Female infertility 0.3896672504378342 0.4949415025041211 0.6206414135741651 1.0 0.8079293940783332 4 Q15645,Q9NVR5,Q86Y56 3 +Optic nerve hypoplasia 0.361186226221707 0.4909262949490835 0.6234785784362185 1.0 0.8093663421096784 21 Q9NVI7,P37268,Q9UHX1 3 +Generalized muscle weakness 0.3312105615269419 0.4908446383145393 0.6235363356033852 1.0 0.8093663421096784 34 P42858,P21912,Q15165,P12235,P10253 5 +Abnormality of the thenar eminence 0.3763696956332366 0.4907269093332337 0.6236196114477308 1.0 0.8093663421096784 17 P42766 1 +Adducted thumb 0.3419564604052278 0.4904213881264198 0.6238357449622811 1.0 0.8093663421096784 27 P42892,Q96L58,Q86XL3 3 +Prolonged bleeding following procedure 0.3442240373395513 0.4890256634585311 0.6248235279784442 1.0 0.8104215831903551 2 P49257 1 +Abnormal bronchoalveolar lavage fluid morphology 0.3439323220536751 0.487531348704297 0.6258818327651685 1.0 0.8115676793265345 2 P53621 1 +Apraxia 0.3042963935618761 0.4848836806371109 0.6277588591766139 1.0 0.8133205966911735 70 P05067,P42858,P04062,Q9Y619,O14773,Q7LGA3,O43292,Q13426 8 +Abnormal thorax morphology 0.2777529770950651 0.4824346200492689 0.6294972326428903 1.0 0.8147041997425754 243 P42858,Q9UHX1,P55011,Q9Y619,Q9Y4P3,P51812,Q9BPU6,Q96HY6,O95202,P21912,Q13510,Q9UM00,P16278,Q9UL01,O95613,Q9UBN7,Q7LGA3,Q9UBM7,P48651,P16435,Q14739,Q96A33,P21964,P42766,P04062,P51648,Q9P2D1,O75844,P51798,Q6ZXV5,Q15427,Q9NSD9,Q9Y487,O75845,P42345,Q13535,Q9BUK6,Q96L58,Q96AY3,P62847,Q8TAA9,P50570,Q03164,Q9NVI7,P54802,Q9BTV4 46 +Erythroid hypoplasia 0.3707383277718024 0.4808951041328078 0.6305910525578278 1.0 0.8158524172051428 18 P42766 1 +Soft tissue sarcoma 0.3279722214229585 0.4768074191319498 0.6334992621771467 1.0 0.817565992243062 35 Q15392,Q07812,Q13126,O14965,P21912 5 +Toe syndactyly 0.3080871642540539 0.4741426931537358 0.6353981557448607 1.0 0.8189969738660796 61 Q15427,P51812,Q9UHX1 3 +Atrophy degeneration affecting the cerebrum 0.2775493558985848 0.4739022911459452 0.635569585319447 1.0 0.8189969738660796 256 P42858,Q9UHX1,O75165,P55011,Q9Y619,Q9Y4P3,Q2M389,P51812,Q9H9S5,Q9BPU6,Q6DKK2,Q2TAA5,Q15043,Q96RL7,Q9UM00,P16278,Q9UL01,Q7LGA3,P13073,P00374,P50897,P43034,Q96N66,Q96A33,Q96N67,Q9NWS8,P04062,Q9Y5P6,Q16625,P03886,P07602,Q13409,Q8WVX9,O76024,P00403,Q01105,Q9NSD9,O75845,P05067,O14678,P17900,O14773,P51970,Q9NZJ7,O75503,Q9BT22 46 +Chorea 0.3032434115987335 0.4735937614067951 0.635789625085756 1.0 0.8189969738660796 88 P15289,P42858,Q96RL7,Q5XKP0,O43681,P17900,Q96IX5,P03886,P55011,Q13315,P07602,Q2M389,Q9NZJ7,Q9BPU6,Q9P0J0,Q99720,Q01105,Q96N66 18 +Neoplasm 0.2766747748494791 0.4716435334105808 0.6371812479832202 1.0 0.8193166216861946 233 P15289,Q15392,Q13423,Q9UHX1,Q5HYI8,Q13426,O95202,P21912,P42892,Q7LGA3,Q9UBM7,Q6PGP7,Q14691,P16435,O43681,O15360,P42766,P04062,Q13315,P07602,Q9P2D1,Q13126,Q06136,O14965,P49327,P42345,Q13535,Q9BUK6,Q96L58,P62847,Q8TAA9,Q07812,P10619,P28340,Q9NZJ7,Q92733,P16615,Q07864 38 +Profound global developmental delay 0.3800267041768012 0.4704326446551736 0.6380459457443097 1.0 0.8199258832819613 15 P55011,P37268,Q9H490,O75381 4 +Abnormal t cell subset distribution 0.3765404755367769 0.4702848402413895 0.6381515268935798 1.0 0.8199258832819613 16 Q96MG7,P49327,Q13315,Q13432 4 +Erythroderma 0.4143513028318645 0.4694864835930529 0.6387219439575058 1.0 0.8204318915196493 9 P48449 1 +Apnea 0.3009584401531325 0.4601004331204901 0.6454441332223337 1.0 0.8272368118485415 95 Q7KZN9,P04062,Q96CU9,P03886,P07602,P51798,P51812,Q9NZJ7,Q9P0J0,Q96KP1,O43772,Q86Y39,Q96A33,P23786 14 +Cirrhosis 0.3221961140623544 0.4558820172610964 0.6484748215029614 1.0 0.8290589092284921 37 P04062,Q15904,Q6PGP7,Q14108,Q14739,Q9NSD9 6 +Abnormality of the nasal dorsum 0.3071143158166398 0.4541848636141242 0.6496957765265536 1.0 0.8297104391815195 57 Q13535,P16278,O95613,O75844,P28340,Q6PGP7,Q13426,O95202 8 +Abnormal proportion of cd4 positive t cells 0.3981878826832776 0.4479315046335143 0.6542026305892679 1.0 0.8338615697442355 12 Q96MG7,Q13315,Q13432 3 +Abnormal tongue physiology 0.3567498720104362 0.4470990524773586 0.6548035431366557 1.0 0.8341698002228961 20 Q13510,Q9NWS8,P10253 3 +Pallor 0.3086546889158769 0.4463941651097189 0.6553125468909697 1.0 0.8345893894888831 51 P42766,O15360,P62847,P00374,Q9H061,P21912 6 +Premature graying of hair 0.4060604796366387 0.4415508437292106 0.6588142616906747 1.0 0.8374421504281463 10 Q13126,Q13315 2 +Glomerular deposits 0.3560854937269448 0.4408611040910176 0.6593135538759958 1.0 0.8378446188950618 3 P52429 1 +Cerebral hemorrhage 0.3818927883330331 0.4383294720342467 0.6611474644265254 1.0 0.8391810401442693 14 P05067,P23786 2 +Abnormal respiratory system morphology 0.2678457322659625 0.4375751526802403 0.6616942864270068 1.0 0.8391810401442693 329 Q15392,P42858,Q13277,Q9UHX1,Q15165,Q96MG7,P55011,Q9Y4P3,P09601,Q14108,Q96HY6,O95202,Q13510,P16278,Q7LGA3,Q6PGP7,P16435,Q14739,O15360,P04062,Q03519,Q13315,P07602,Q9P2D1,O75844,Q8N5M9,P51798,Q03518,Q15427,Q9NSD9,Q9Y487,P10253,P49748,Q96L58,Q8IZA0,Q8TAA9,Q9NZJ7,Q9NPL8,Q9NZ08,P54802,Q13432,Q07864 42 +Multifocal epileptiform discharges 0.3290124723598174 0.4360669251573802 0.6627881734139709 1.0 0.8392973610312547 30 Q96N67,P55011,Q2M389,Q96C86,Q6P1N0,Q9UBX3,O75503,Q9NZ01,Q96N66 9 +Sleep wake cycle disturbance 0.3944525547445304 0.4360467031151009 0.6628028449469785 1.0 0.8392973610312547 5 Q14683,Q05086,Q9Y4R8,Q9UBM7 4 +Abnormal number of incisors 0.3944525547445294 0.4360467031150975 0.6628028449469809 1.0 0.8392973610312547 5 P38919,A5YKK6,P54132,Q14683 4 +Tetraplegia tetraparesis 0.306448768110896 0.4347411960917604 0.6637502923386003 1.0 0.8400391877431591 52 P15289,Q13423,P17900,P43034,P07602,P51970,Q9UBX3,Q9NZJ7,O43681,P21912 10 +Neoplasm of the rectum 0.3952402619907301 0.4333632627244521 0.6647508852453046 1.0 0.8406185663717161 12 P28340,P21912 2 +Leukopenia 0.3105380555368998 0.4323506356072713 0.665486590362417 1.0 0.8409216037103319 47 P42766,P04062,Q14108,P62847 4 +Abnormal dermatoglyphics 0.2996281185931778 0.4276257660743496 0.668923603812591 1.0 0.8436253053881744 80 Q13535,Q9UHX1,Q9Y4P3,Q9P2D1,Q15907,P51812,O95202,Q9Y487 8 +Nephrogenic diabetes insipidus 0.3319719953325556 0.4273908394412776 0.6690946785012142 1.0 0.8436253053881744 2 Q9H267 1 +Aplasia hypoplasia of the hallux 0.3484434742399467 0.4264540884385956 0.6697769957544686 1.0 0.8436253053881744 22 O95202,Q9UHX1,Q7LGA3 3 +Neuronal loss in basal ganglia 0.3920158599092105 0.4253190269383008 0.6706041250594978 1.0 0.843885906020159 5 P42858 1 +Hyperreflexia 0.2748865594686279 0.4232057037150071 0.6721451857097467 1.0 0.8451646051030046 248 P15289,P42858,Q6PJG6,Q9P032,Q96CU9,Q96IX5,P55011,Q9Y619,Q9Y4P3,Q86XL3,Q9H9S5,Q9P0J0,Q9BQT8,Q6DKK2,Q99720,Q2TAA5,P21912,Q15043,P49902,Q15041,Q9NR77,O43292,P13073,P42695,Q14739,O43681,O15360,Q96N66,Q16625,P04062,P03886,P07602,Q13409,O14949,Q96SN8,Q15067,Q5XKP0,P17900,O14773,Q9NZJ7,O75503,Q9NZ08,Q7KZN9 43 +Diminished motivation 0.3392052513923447 0.4229278427110771 0.6723479079769059 1.0 0.8451646051030046 25 P17900,P42858,P04062 3 +Macroglossia 0.3179514222371536 0.4208865246451803 0.6738379456130088 1.0 0.8465795282093129 37 P16278,P10253,Q9Y4P3,Q7LGA3,Q96A33,P21912 6 +Abnormality of the shoulder girdle musculature 0.3194537337926115 0.4202662650512268 0.6742909512062614 1.0 0.8469196429587159 36 O75190,Q9BTV4,Q9Y5P6,P07602,Q9H9S5,Q9NZJ7,P12235,Q9Y487 8 +Metaphyseal dysplasia 0.4005727119810118 0.4160055453040078 0.6774059454563366 1.0 0.8495716587706686 10 Q07864,O95831,Q99575,Q9UBN7 4 +Widened subarachnoid space 0.3279662935538855 0.4156048005764968 0.6776992132918203 1.0 0.8495716587706686 28 P03886,P51812 2 +Abnormal sperm motility 0.3897810218978145 0.4155449871576905 0.6777429893666582 1.0 0.8495716587706686 5 Q9UBS4,Q9NVR5,Q86Y56,Q14697 4 +Adrenal hypoplasia 0.3998081264659355 0.4124752726595818 0.6799911012210949 1.0 0.8513173420299668 10 O75844 1 +Cerebral hypoplasia 0.3660630402227979 0.4116442487035078 0.6806001940123685 1.0 0.8518503505876789 16 Q86XL3,P42695,Q9UBM7 3 +Recurrent fractures 0.3209604254863188 0.40959090396225 0.682106070554938 1.0 0.8534153486048398 34 Q96L58,Q9P2D1,P51798,Q13126,P16435 5 +Clitoral hypoplasia 0.4060363997116685 0.409188081666522 0.6824016401349504 1.0 0.8534153486048398 6 Q9Y619,Q15042,Q9H2M9 3 +Hypoplastic labia minora 0.4060363997116685 0.409188081666522 0.6824016401349504 1.0 0.8534153486048398 6 Q9Y619,Q15042,Q9H2M9 3 +Expressive language delay 0.3901511534761905 0.4084656179085811 0.682931867650681 1.0 0.8538486160132035 12 Q9UHX1 1 +Pyridoxine responsive sideroblastic anemia 0.4057332264716444 0.4079073186590091 0.6833417194577844 1.0 0.8539014600863009 6 Q9NVS9,O15360 2 +Macular purpura 0.3618438809969054 0.4072285932948862 0.683840102721367 1.0 0.8542944655131678 17 P38435,Q16625,P04062 3 +Short digit 0.2727139477191273 0.4059251009923623 0.6847976341556605 1.0 0.8550026825493291 161 P42858,Q9UHX1,P55011,P38435,P51812,O95202,P21912,Q13510,O95613,Q7LGA3,Q9UBM7,P13073,P48449,P16435,Q14739,O15360,P42766,Q9P2D1,O75844,P51798,Q06136,Q15427,P42345,P62847,Q03164 25 +Bifid uvula 0.3125223549851904 0.4041750740864115 0.6860839817966173 1.0 0.8554874340920784 39 Q15392,Q9Y619,P62266,Q6PGP7,Q9H9S5,P48651,O43505 7 +Abnormal sacrum morphology 0.3245599233940486 0.4028997193446599 0.6870219978122205 1.0 0.8564272073613031 30 Q9UM00,P01889,P43034,Q9Y4P3,Q8TAA9,Q03164,Q14739,O95202 8 +Protuberant abdomen 0.4026054118493664 0.4003428217755595 0.6889040320493771 1.0 0.8581678996448393 7 P04062 1 +Abnormal male reproductive system physiology 0.3092075153865167 0.3999990483198047 0.6891572177302832 1.0 0.8581678996448393 43 P04062,Q13423,Q9Y4P3,Q13315,P16435,O15360 6 +Failure to thrive 0.2688381002405158 0.3990238705133943 0.6898756157287413 1.0 0.8582890652791421 315 Q15392,Q13423,Q9P032,Q96CU9,Q96MG7,P51571,Q9Y619,Q9Y4P3,Q9P0J0,Q9BQT8,O43676,O95202,Q2TAA5,P21912,Q13510,P42892,Q9Y6B6,O15228,Q15904,Q9UBM7,P13073,Q6PGP7,Q14739,P12235,Q86Y39,Q16625,P04062,P03886,Q13315,P07602,O00116,Q9P2D1,O75844,Q8N5M9,P00403,Q9NSD9,Q9Y487,P10253,Q15067,Q16836,Q15800,Q5XKP0,Q96L58,Q9NZJ7,Q03164,Q9NPL8,Q99797,P37268,Q7KZN9 49 +Abnormality of circulating adrenocorticotropin level 0.3988965541545551 0.3988910212557744 0.689973505318557 1.0 0.8582890652791421 9 Q13423 1 +Misalignment of incisors 0.3856934306569379 0.3978339218818259 0.690752610669441 1.0 0.8586790701972372 5 Q9BSJ2,Q96N67,Q8WXI9,Q99496 4 +Degeneration of the striatum 0.3856769510309127 0.3977629618056973 0.6908049215430498 1.0 0.8586790701972372 5 P42858 1 +Abnormality of the chin 0.2967007174020145 0.3970124839191676 0.6913582547211323 1.0 0.8586790701972372 90 P42345,P16278,Q9UHX1,Q9BUK6,P55011,Q9Y4P3,Q7LGA3,Q9P2D1,O75844,P51812,Q13426,P48651,Q9NVI7 13 +Synostosis involving bones of the upper limbs 0.3217011066234584 0.3966342242696193 0.691637211015498 1.0 0.8586790701972372 32 Q96L58,Q9Y4P3,P16435,O95202,Q15427 5 +Impairment of activities of daily living 0.3011075847177026 0.396559922567396 0.6916920114372123 1.0 0.8586790701972372 59 P15289,P21964,Q9H5V9,O43681,O15269,P07602,Q8TAA9,Q8WVX9,P50570,P51812,Q9NZJ7,Q9BPU6,Q99720 13 +Cerebellar cortical atrophy 0.3464921790480135 0.3959203046061355 0.6921638215408186 1.0 0.8586790701972372 3 O75845 1 +Fever 0.2966826108257758 0.3954749197629724 0.6924924274093915 1.0 0.8586790701972372 89 Q13510,P49327,Q13546,P10253,P03886,Q9NR77,Q13315,P07602,P06280,Q9P2D1,Q9NZJ7,P49770,P00403,Q14739,Q9NZ08,P23786 16 +Abnormal cerebral ventricle morphology 0.2735833283020059 0.3949916477638139 0.6928490519799135 1.0 0.8586790701972372 258 Q15392,P42858,Q9UHX1,Q96CU9,P14854,Q86XL3,P51812,Q9H9S5,Q9BPU6,Q13426,Q8NAT1,O95202,O43819,Q96RL7,Q9UM00,P16278,O95613,Q9UBN7,Q9UBM7,P48651,P42695,P16435,O15360,P23786,P21964,Q16625,P04062,P07602,Q9P2D1,P51798,Q96SN8,Q6ZXV5,Q01105,Q15427,Q9Y487,P42345,Q96L58,P51970,Q8TAA9,Q96KP1,Q9NZJ7,Q9NPL8,O43505 43 +Non hodgkin lymphoma 0.3979665011411162 0.3947340040774235 0.6930392047665586 1.0 0.8586790701972372 9 Q13315,Q07864 2 +Gastrointestinal carcinoma 0.3214436312515876 0.394679656279001 0.6930793183899353 1.0 0.8586790701972372 32 P42766,P62847,Q07812,P28340,Q07864 5 +Narrow mouth 0.2965636306243526 0.3927205751703485 0.6945258723705989 1.0 0.8600125807659389 79 Q15392,P42858,P04062,P21964,Q9UL01,P55011,Q9Y619,Q15555,Q7LGA3,O75844,P28340,Q6PGP7,Q9P2D1,Q9BPU6,P16435,P43034,Q9NVI7,Q9Y487 18 +Abnormality of facial skeleton 0.2598300893267523 0.391201150255259 0.695648558142083 1.0 0.860509228422376 353 Q15392,P42858,Q6PJG6,Q9UHX1,P55011,Q9Y619,Q9Y4P3,Q86XL3,P51812,Q9H9S5,Q13426,O95202,Q2TAA5,Q15043,Q96RL7,P16278,O95613,O15228,Q9UBN7,Q7LGA3,Q9UBM7,P16435,Q14739,O15360,P42766,P04062,Q03519,Q16625,Q13315,Q9P2D1,O75844,P51798,Q03518,Q15427,Q9Y487,O14678,Q13535,Q96L58,P62847,P28340,Q9BT22,Q9NVI7,P37268,Q13432,Q07864,P51571 46 +Abnormal metabolism 0.3028256367459608 0.3905214677403718 0.6961509840332956 1.0 0.8606792474837572 51 Q8N511,O14678,Q9Y6B6,Q15904,Q9NSD9,Q9BT22,Q2TAA5,Q9Y487,P51571 9 +Abnormality of neuronal migration 0.2743838173878326 0.3902234634534861 0.6963713128793685 1.0 0.8606919711725316 155 Q15392,P55011,Q86XL3,Q2M389,P51812,Q9H9S5,Q13426,Q8NAT1,Q2TAA5,Q16134,O75381,Q9UBM7,P42695,P43034,Q96N66,P23786,Q9NWS8,Q16625,Q9Y5P6,Q13409,Q96SN8,Q6ZXV5,Q01105,Q15427,Q9Y487,P42345,Q13535,P78527,O43505,P37268 30 +Facial erythema 0.3449080828713236 0.3886398654071073 0.6975425722448392 1.0 0.8614801778757802 3 Q9H1A4,O00170 2 +Abnormality of the humerus 0.3723520250584088 0.3886091328591033 0.6975653097651067 1.0 0.8614801778757802 14 O15228,O00116,P16435 3 +Melena 0.3443244820542889 0.3859681404541392 0.6995202642539033 1.0 0.8625188820922598 3 Q6YHK3,Q9UER7 2 +Peripheral neuropathy 0.263804317131087 0.3846578331078155 0.7004909400653516 1.0 0.8631315720598572 175 P15289,Q96CU9,Q8IV08,Q13426,Q9P0J0,Q96RL7,Q15041,Q9NR77,O43681,P12235,O95470,Q9NWS8,O15269,P03886,Q9Y2R0,P07602,P00403,Q8TB36,Q15067,Q16836,Q9NZJ7,Q9NPL8,Q9NVI7,P54802,Q7KZN9 25 +Headache 0.2948701718469294 0.384545058060313 0.7005745067235734 1.0 0.8631315720598572 72 P05067,P04062,P21912,P03886,Q8TAA9,P00403,P12235,Q9NSD9,P23786 9 +Secondary microcephaly 0.2956341660213655 0.3842200837283838 0.7008153339717067 1.0 0.863199374770029 77 Q6PJG6,Q5XKP0,Q9UHX1,Q96CU9,Q96KP1,Q9BT22,P00374,P50897,Q86Y39,Q9Y487,Q15043 11 +Ovarian cyst 0.3640927137897654 0.3838753504184255 0.7010708367854117 1.0 0.8632852127498073 15 Q9Y4P3,P21912,P16435 3 +Spina bifida occulta 0.3440425001465557 0.3832691441608932 0.7015202150921498 1.0 0.863609676554883 21 Q9Y4P3,Q9UHX1 2 +Hypotelorism 0.3098572731642669 0.3818211819851286 0.7025940060559379 1.0 0.8642445729774656 39 Q9NXE4,P18074,Q7Z6Z7,Q9H2M9,Q9BUK6,Q9BXW9,Q15042,Q15904,Q9UDR5,Q9Y366,Q9Y3C4,Q13426,Q9BPU6,Q08J23,A5YKK6,Q9NSD9,O14617,Q93008 18 +Vasculitis 0.3929977835168303 0.381357791066937 0.702937776590876 1.0 0.8644385680363181 10 P49327,Q9NZ08 2 +Osteomyelitis 0.363550669177726 0.3809963958642583 0.7032059228992222 1.0 0.8645394860518091 15 P51798,Q13126 2 +Abnormality of the musculature of the lower limbs 0.3231142527776434 0.3806433961404308 0.7034678756169783 1.0 0.8646327381260532 28 Q96RL7,Q9Y5P6,Q9NR77,P50570,Q9H9S5,Q8NAT1,Q9BTV4 7 +Alopecia 0.3048340522540314 0.3800908413861926 0.7038779840498419 1.0 0.864907990980049 47 Q13535,O75844,P48449,Q06136,P47985 5 +Abnormality of salivation 0.3063320693991202 0.3785728645311662 0.7050050758303807 1.0 0.8656061264027349 44 Q96RL7,Q15165,Q9NR77,P51812,Q14739 5 +Abnormal muscle glycogen content 0.3803687251028789 0.3750979890053927 0.7075875925719912 1.0 0.8674020724530523 5 Q9BUK6 1 +Weakness due to upper motor neuron dysfunction 0.2747344766301285 0.3716133878652657 0.7101807197813166 1.0 0.8698918070403365 151 P15289,Q13423,Q96CU9,Q9Y619,Q9H9S5,Q9P0J0,Q6DKK2,P21912,Q13510,P49902,Q15041,Q9UBX3,P04062,P03886,P07602,Q9P2D1,P00403,P42345,Q5XKP0,P17900,Q96L58,Q9NZJ7,Q9NZ08,Q7KZN9 24 +Spastic tetraparesis 0.3282231289712299 0.369670830150931 0.711627768678845 1.0 0.8708799980464326 26 P17900,Q9NZJ7,P07602 3 +Severe varicella zoster infection 0.3619381202568654 0.3695238905640325 0.7117372691739785 1.0 0.8708799980464326 4 Q9H0U3,P54132,P17812 3 +Abnormal gastrointestinal motility 0.3206131334779071 0.3678794953131837 0.7129630901067858 1.0 0.871960112550946 29 Q5HYI8,P03886,P06280,Q9UBM7,P00403 5 +Radial bowing 0.3784182845655685 0.3668685548466657 0.7137170680427367 1.0 0.871960112550946 5 Q96L58 1 +Right ventricular cardiomyopathy 0.3958628349298748 0.3668296569754601 0.7137460843803805 1.0 0.871960112550946 6 Q99959 1 +Dermatological manifestations of systemic disorders 0.2934065799780304 0.363794880484152 0.7160111858707912 1.0 0.8742675347058333 74 Q14739,O15118,P49748,Q5HYI8,O75844,P51812,P00374,Q6PGP7,O43772 9 +Abnormal dentin morphology 0.3945520489051433 0.3614686078831677 0.7177491681055579 1.0 0.8761593891272784 6 Q96L58 1 +Upslanted palpebral fissure 0.2926785580555997 0.3597492197715248 0.719034680801979 1.0 0.8770688453641582 96 P21964,Q9UM00,Q9UHX1,O95613,Q86XL3,O75381,Q13409,Q15555,Q15907,Q7LGA3,Q96KP1,Q9UBM7,O00203,Q13426,P42695,Q96SN8,Q9NVI7,O15360 18 +Bladder diverticulum 0.3915695654312488 0.3594354671026261 0.7192693461184771 1.0 0.8770688453641582 8 Q9Y4P3 1 +Abnormal hand morphology 0.2859720630504884 0.3587915317530236 0.7197510481407463 1.0 0.8770688453641582 114 Q13510,P42766,Q9UHX1,O15360,P62847,Q9P2D1,O75844,P38435,P51812,P13073,Q03164,P51798,P16435,O95202,P21912 15 +Abnormal blood potassium concentration 0.3593231077823962 0.3587051845581179 0.7198156494562065 1.0 0.8770688453641582 15 P0DP25,P11166,Q13423 3 +Vitritis 0.338194305238625 0.3582555222219045 0.7201521001108129 1.0 0.8772487302346189 3 P53701 1 +Normochromic anemia 0.3374276811980676 0.357128530758903 0.7209955864844724 1.0 0.8778159053477094 22 P42766,P47985 2 +Abnormal basal ganglia mri signal intensity 0.3174073219192814 0.356852940593886 0.7212019011084889 1.0 0.8778370533272307 31 P03886,Q9P0J0,P16278,Q7KZN9 4 +Decreased fertility in females 0.390122735242553 0.3532871092355101 0.7238732086002537 1.0 0.8800335677291012 8 P54132,Q9NVR5,P51809,Q86Y56,Q15645,O00170,Q8IY37 7 +Abnormal motor nerve conduction velocity 0.3342509891465862 0.3528775548144487 0.724180238416892 1.0 0.8800335677291012 23 Q99720,Q9NR77 2 +Abnormal clavicle morphology 0.340977635126961 0.3515521851378033 0.7251741295003586 1.0 0.8801355814155346 20 O95613,Q9Y619,Q96AY3,O75844,Q14739 5 +Abnormal cns myelination 0.2742905139325683 0.348764033206184 0.727266467286267 1.0 0.8822141010475186 148 P15289,Q9P032,Q96CU9,P14854,Q9P0J0,Q99720,O43676,P21912,Q7LGA3,P49770,Q86Y39,Q9Y584,Q9NWS8,P03886,P07602,P51648,Q8TB36,P10253,Q15067,Q96KP1,Q9NZJ7,Q9NPL8,Q7KZN9 23 +Chronic diarrhea 0.3381800722066492 0.3475765109774824 0.7281582491730851 1.0 0.8826045462191895 21 Q13510,Q13277,P50851,Q15904,Q9P2D1,Q9BT22,Q96A33 7 +Oral cleft 0.2634466083897374 0.3459196846968601 0.7294030746218647 1.0 0.8836523297765797 172 Q15392,Q9UHX1,Q9Y619,Q9H9S5,Q8NAT1,O95202,Q9UM00,Q9UL01,Q15555,Q7LGA3,Q9UBM7,Q6PGP7,P48651,P16435,Q14739,O15360,Q9NWM8,P21964,P42766,Q9Y5P6,P62266,Q9P2D1,O75844,Q15427,Q13535,Q96L58,P62847,Q8TAA9,O43505 29 +Aplasia hypoplasia of the vagina 0.3352786693901454 0.3453077574673844 0.7298630153277261 1.0 0.8837173435047104 3 P51809,Q8IY37 2 +Enuresis 0.3147607934655776 0.345214246759698 0.7299333090163964 1.0 0.8837173435047104 2 Q9UJS0 1 +Malignant genitourinary tract tumor 0.3398796561234032 0.3450635130793172 0.7300466230244096 1.0 0.8837173435047104 20 P42766 1 +Abnormal epidermal morphology 0.3472433976465889 0.3448361143939183 0.7302175810836382 1.0 0.8837173435047104 18 O75844,Q06136 2 +Aplasia hypoplasia of the 5th finger 0.3636622175949411 0.3445022128723479 0.7304686321401856 1.0 0.88379095440711 14 Q9UHX1 1 +Abnormal pleura morphology 0.3271949767467656 0.3426101565306722 0.73189176024406 1.0 0.8848215243543853 25 P49327,P01889,Q96L58,Q14739,Q9NZ08 5 +Platyspondyly 0.3108882821457434 0.3411504200614921 0.7329903457208018 1.0 0.8858912591693515 35 P16278,Q6NUQ1,Q01968,Q96L58,Q96AY3,Q9UBN7,Q14739,Q96HY6 8 +Wide intermamillary distance 0.3174617048353306 0.3405041692925472 0.7334768835348169 1.0 0.8858912591693515 28 O14678,Q9UM00,Q92974,Q9UBM7,Q15555,Q9P2D1,Q96KP1,P23786 8 +Curly hair 0.3758352560294216 0.3403261207514435 0.7336109483832813 1.0 0.8858912591693515 12 P42345,Q6PGP7,Q96A33 3 +Sunken cheeks 0.3341114677560653 0.3401680241994522 0.7337299968324602 1.0 0.8858912591693515 3 P17980,P04350 2 +Keratosis pilaris 0.3341114677560619 0.3401680241994366 0.733729996832472 1.0 0.8858912591693515 3 Q02750,P04049 2 +Abnormality of facial soft tissue 0.2776014275841059 0.338785011659207 0.7347716932383785 1.0 0.8864578776384073 127 Q9UHX1,O75165,Q9Y4P3,P51812,Q9H9S5,Q9BQT8,P21912,Q13510,Q15043,O43819,Q9UL01,O75381,Q9UBM7,P48651,P16435,P12235,Q9H5V9,P04062,Q9P2D1,O75844,P51798,P10253,Q9BUK6,Q15907,P50570 25 +Broad finger 0.3023744866935707 0.337702658467558 0.7355872711770264 1.0 0.8869811736019892 42 Q96L58,P51812,Q9UHX1,Q7LGA3 4 +Weakness of long finger extensor muscles 0.3127187864644057 0.3358496724771556 0.7369842302933105 1.0 0.8879742567278839 2 P31483 1 +Lymphoma 0.3226451120127318 0.3320297104030896 0.7398668247530757 1.0 0.8907544098996605 26 Q13315,Q13426,Q07864,Q9P2D1 4 +Abnormal intraocular pressure 0.386601315904536 0.3294531875885695 0.7418131715763585 1.0 0.8922681262492561 6 Q9UL01,Q15043 2 +Displacement of the urethral meatus 0.2784569702701303 0.3294497339348645 0.7418157816338029 1.0 0.8922681262492561 123 Q9UHX1,Q9Y619,O95202,O95613,Q9UBM7,Q9UBX3,Q6PGP7,P48449,P48651,P16435,O15360,P42766,O75844,P42345,Q13535,P62847,P37268,Q07864,P51571 19 +Congenital contracture 0.3002786375209672 0.3293484442734304 0.7418923314035464 1.0 0.8922681262492561 45 Q15392,P04062 2 +Abnormality of the humeroradial joint 0.359934572796473 0.3259596309187821 0.7444548983082686 1.0 0.8946114086871577 14 Q96L58,Q13535,P16435 3 +Cerebral cortical atrophy 0.2840440815430713 0.3257534293274476 0.7446109163567023 1.0 0.8946114086871577 113 P42858,O75165,P55011,Q9Y619,Q9Y4P3,P51812,Q9H9S5,Q9BPU6,Q96RL7,Q9UM00,Q7LGA3,P43034,Q96N67,Q9NWS8,P04062,Q16625,P03886,O76024,P00403,P05067,P51970,O75503 22 +11 pairs of ribs 0.3723518210792174 0.3242095977794155 0.7457793562226793 1.0 0.8949575391791567 12 Q14739,Q96L58,Q13535 3 +Iron deficiency anemia 0.3680419209793608 0.3240315005351981 0.7459141857605203 1.0 0.8949575391791567 5 P49327 1 +Abnormality of thyroid physiology 0.290705284486261 0.3233369833352184 0.7464400482822282 1.0 0.8949575391791567 81 O95470,Q13423,P03886,Q9Y4P3,Q6PGP7,Q13426,P00403,P12235 8 +Perisylvian polymicrogyria 0.3677738177739071 0.3229465939590187 0.7467356884234058 1.0 0.8950810135229987 5 P42345 1 +Narrow forehead 0.2970664911644253 0.3215740460963215 0.7477754084653869 1.0 0.8951343989055033 49 Q9UM00,Q9UHX1,O75845,P55011,Q9UBM7,Q7LGA3,O43292,Q96A33 8 +Abnormal meningeal morphology 0.321044590343934 0.3213511658786697 0.7479442860377559 1.0 0.8951343989055033 26 P21964,Q9UHX1,Q15904,Q8TAA9,Q9H9S5,O75845 6 +Abnormal blood glucose concentration 0.2897248338315495 0.3208962380652166 0.7482890248892646 1.0 0.8951343989055033 95 O95470,P42345,Q16836,Q13423,Q5XKP0,Q96CU9,P49748,P03886,P22695,O75844,Q9NPL8,O43772,O43676,Q9NSD9,Q86Y39,P23786 16 +Absent testis 0.3843588006950287 0.3205849128610667 0.7485249724131093 1.0 0.8951343989055033 6 O15360,Q8IY37,Q9BXW9 3 +Abnormal thrombocyte morphology 0.2760396494777747 0.3195824146627601 0.7492849068754848 1.0 0.8951343989055033 130 Q14108,Q13510,Q15904,Q6PGP7,P00374,Q14739,O15360,P47985,P21964,P42766,P04062,Q16625,P07602,O76024,P51798,O75845,P49327,P42345,O14678,P62847,O00203,Q9NZJ7 22 +Wide anterior fontanel 0.3332307320332185 0.3179589564033494 0.7505160705213425 1.0 0.896144349432577 21 P42345,Q96MG7,P16435,Q16134,Q9Y487 5 +Meningocele 0.3709068246594647 0.3175813363812995 0.7508025331728443 1.0 0.8962021947769736 12 P21964,Q9H9S5,O75845,Q8TAA9 4 +Hypoplastic helices 0.3086347724620747 0.3173865509835323 0.7509503108624103 1.0 0.8962021947769736 2 Q9UDR5 1 +Hepatic fibrosis 0.3108184681418774 0.3152259159546821 0.7525901297952937 1.0 0.8974675931799113 32 Q13510,P49748,Q6PGP7,P04062 4 +Abnormality of dental structure 0.2896804265047371 0.3148245598590291 0.7528948631792605 1.0 0.8976005990071451 78 Q13535,P16278,P55011,Q96L58,Q9Y4P3,Q96AY3,O95613,P51648,Q9UBM7,O75844,P51798,P48651,Q9Y487 13 +Supernumerary spleens 0.363918381888892 0.3136578790129817 0.7537808950635456 1.0 0.898426382366658 13 Q96KP1,O95202 2 +Increased circulating igm level 0.3784959612074645 0.3104250415682247 0.7562377536470142 1.0 0.8999186118505015 9 Q96MG7 1 +Female reproductive system neoplasm 0.3319554303570006 0.3104086799327682 0.7562501942881792 1.0 0.8999186118505015 21 Q07812,P28340,Q07864,P21912 4 +Abnormality of prothrombin 0.349882343412906 0.3100326220501521 0.7565361489549749 1.0 0.8999186118505015 15 Q16836,Q5XKP0,Q6NUQ1,Q9UJS0,P38435,P49257,A2RRP1 7 +Muscle fibrillation 0.3441479207608229 0.3099717258898763 0.7565824575738396 1.0 0.8999186118505015 17 Q13510,Q9NWS8,Q9BQT8 3 +Limb dystonia 0.3470224524156829 0.3094530158815786 0.7569769471578867 1.0 0.9001573832852678 16 Q99720 1 +Abnormal circulating iga level 0.3439907739299555 0.3091335735027442 0.7572199211433872 1.0 0.9002159042047536 17 P49327,P42345,P50851,Q15904,Q13315 5 +Abnormal leukocyte count 0.2801025964267928 0.3085814008907787 0.7576399707697887 1.0 0.9004848565352874 118 O95470,P42766,P04062,O14678,Q96MG7,Q13315,P62847,Q8N5M9,Q6PGP7,Q13426,Q14108,Q14739,O15360,Q13432 14 +Abnormality of cardiovascular system electrophysiology 0.2768384640437589 0.3063521801465824 0.7593365137313635 1.0 0.9013483502289 123 Q6PJG6,Q9Y4P3,O43572,O43772,P21912,P42892,P0DP25,P12235,P47985,P23786,P04062,P13473,P03886,P07602,Q99959,P00403,Q8TB36,P10253,Q16836,P49748,Q9NZJ7 21 +Aplasia hypoplasia of the thymus 0.3463757352161309 0.3060955977885791 0.7595318596261633 1.0 0.9013499412064252 16 Q96MG7,Q6PGP7,Q13315,Q9P2D1 4 +Multiple lipomas 0.3633858818444085 0.3053545937494875 0.7600961002427487 1.0 0.9016013406363284 5 Q8TAA9 1 +Abdominal aortic aneurysm 0.3455925277291369 0.3009816620764963 0.7634284780802616 1.0 0.9050494282115068 4 O15460,Q96MF7,P01889 3 +Menorrhagia 0.3450087565674322 0.2986192310687543 0.7652305903475116 1.0 0.9059948042637416 4 P35579,Q9UPZ3,P49257 3 +Stage 5 chronic kidney disease 0.3084885594367615 0.2981470140119308 0.7655909602969113 1.0 0.9059948042637416 32 P23786 1 +Dystonia 0.2607156866211801 0.297571259308013 0.7660304130943927 1.0 0.9062840079543032 172 P15289,P42858,Q9P032,Q96CU9,P55011,Q9P0J0,Q6DKK2,Q99720,Q15043,Q96RL7,P16278,O43681,P04062,P03886,Q13315,P07602,O14949,Q15067,O15118,P17900,Q96L58,Q15907,Q9NZJ7,Q7KZN9 24 +Sepsis 0.3417465200139064 0.2972171833482952 0.7663007039025815 1.0 0.9063729812452632 17 P42892,P01889,P50851,Q9P2D1,Q9BT22 5 +Abnormal skin morphology of the palm 0.286792577484008 0.2948788121733419 0.7680864580881404 1.0 0.9077918301392776 99 Q13535,Q9UHX1,Q9P2D1,Q15907,P51812,Q06136,Q14739,P16615,O95202,Q9Y487,P21912 11 +Vertical supranuclear gaze palsy 0.371343173352246 0.2940798117425141 0.7686969170528697 1.0 0.9080931278337352 11 O15118 1 +Male infertility 0.3744898677548299 0.2937777237031513 0.7689277582647254 1.0 0.9080931278337352 9 O15360,Q86Y56 2 +Retinal vascular tortuosity 0.3464550670649897 0.292769251318933 0.7696985328108932 1.0 0.9085725651023648 15 P03886,Q9Y4P3 2 +Reduced forced vital capacity 0.3599925414845392 0.2919674352362633 0.7703115225867876 1.0 0.9085725651023648 5 Q9H9S5 1 +Broad toe 0.3090295661438416 0.2903562830256445 0.7715436847914376 1.0 0.9088722006949846 30 Q15427,Q9UHX1,Q7LGA3 3 +Pure red cell aplasia 0.3337392861997914 0.2888485585570002 0.772697270754241 1.0 0.910000385278632 19 P42766 1 +Impaired vibratory sensation 0.3093496930423684 0.2879852547853331 0.7733580257320201 1.0 0.9100864710108828 29 Q9Y6B6,Q9Y619,Q96RL7,O14773 4 +Aplasia hypoplasia of the nails 0.2869539182709446 0.2861491042951793 0.7747639233753403 1.0 0.9112792881017294 69 Q96L58,Q9Y4P3,O75844,P51812,P16615,Q9Y487,P23786 7 +Focal myoclonic seizure 0.3717729100211409 0.2826350362259954 0.7774566198811927 1.0 0.9134736936832996 9 O75503 1 +Abnormal glucose homeostasis 0.2596227531264177 0.2824314942173712 0.7776126686434459 1.0 0.9134736936832996 185 Q13423,Q96CU9,Q5HYI8,Q9Y4P3,Q13426,O43772,O43676,P12235,Q86Y39,P23786,O95470,P03886,Q13315,O75844,P00403,Q06136,Q9NSD9,P42345,Q16836,Q5XKP0,P49748,P22695,Q8TAA9,P28340,Q9NPL8 25 +Contractures involving the joints of the feet 0.3268392263704019 0.2804726695538365 0.7791148908680405 1.0 0.914645444159086 21 P49902,P50402,Q8IZA0,Q9H9S5,Q9BTV4 5 +Emotional lability 0.2896134876751261 0.2801041332182168 0.7793976137378005 1.0 0.914645444159086 58 P15289,Q96RL7,Q96CU9,Q15165,P07602,Q9NZJ7,P49770,Q9P0J0,Q7KZN9 9 +Talipes calcaneovalgus 0.373754072505752 0.2796725910864173 0.7797287086369451 1.0 0.9148029243250624 6 Q9NR77 1 +Cleft lip 0.289237348085288 0.2787319473607325 0.7804505433007987 1.0 0.9153762256279606 53 P42766,Q9UM00,Q96L58,P62847,Q9P2D1,Q9H9S5,O95202,Q15427 8 +Abnormal lactate dehydrogenase level 0.3283597428176921 0.2784567221011973 0.780661782498697 1.0 0.9153762256279606 20 Q96RL7,P10253,Q5JRX3,Q9H9S5,O43505,Q8NAT1,P23786 7 +Multiple lentigines 0.3732476635514062 0.2777628689696746 0.7811943962071153 1.0 0.9153762256279606 6 Q02750,P10644,P04049,P36507,P28482 5 +Panhypogammaglobulinemia 0.3732448672977991 0.2777523354673886 0.7812024826979904 1.0 0.9153762256279606 6 Q6PGP7 1 +Hypoplastic female external genitalia 0.3407614427676238 0.2772973347087423 0.7815518059470681 1.0 0.9154629592055046 16 Q9Y619,P16435 2 +Spina bifida 0.2955116188976601 0.277142629658369 0.7816705895755998 1.0 0.9154629592055046 40 P21964,Q9UHX1,Q9Y4P3,Q8TAA9,Q9H9S5,O15360 6 +Mask like facies 0.3669241915611314 0.2750948788531713 0.7832433459387809 1.0 0.9168426770550708 11 P04062 1 +Abnormal uvula morphology 0.2927627524026416 0.2719165975991814 0.7856861488839879 1.0 0.9189870536176804 47 Q15392,Q9Y619,P62266,Q6PGP7,Q9H9S5,P48651,O43505,O15360 8 +Atrophy degeneration affecting the central nervous system 0.2621880302191323 0.2711670243625085 0.7862625738488729 1.0 0.9189870536176804 320 P42858,Q6PJG6,Q9UHX1,O75165,Q15165,P55011,Q9Y619,Q9Y4P3,Q2M389,P51812,Q9H9S5,Q9BPU6,Q99720,Q6DKK2,Q2TAA5,Q15043,Q13510,O43819,Q96RL7,Q9UM00,P16278,Q9UL01,Q7LGA3,P13073,P00374,P50897,P43034,Q86Y39,Q96N66,Q96A33,Q9NWS8,Q16625,P04062,Q96N67,Q9Y5P6,P03886,P07602,Q13409,O76024,Q8WVX9,P00403,Q01105,Q9NSD9,O75845,P05067,O15118,O14678,P17900,P78527,O14773,P51970,Q9NZJ7,O75503,Q9BT22 54 +Accelerated skeletal maturation 0.3675346694483005 0.2709105074429541 0.7864598633628708 1.0 0.9189870536176804 10 Q03164 1 +Focal onset seizure 0.2859747622012575 0.2674073709037597 0.7891555248581708 1.0 0.9205362092612784 89 Q6PJG6,P55011,Q2M389,Q9BPU6,Q9NZ01,P21912,Q9UBX3,P43034,Q96N66,P27635,Q96N67,P03886,P07602,Q8WVX9,P00403,Q6ZXV5,Q01105,P42345,P11166,Q96C86,Q9NZJ7,O75503 22 +Abnormality of the thymus 0.3353248617461152 0.2636927591393735 0.7920166754886797 1.0 0.922660820504257 17 Q96MG7,Q6PGP7,Q13315,Q9P2D1 4 +Partial duplication of the phalanx of hand 0.3287292971389887 0.2613478278745558 0.7938242864668394 1.0 0.9241061475632512 19 P42766 1 +Abnormal proportion of cd8 positive t cells 0.3682286389904268 0.261015993362 0.7940801737471819 1.0 0.9241724667408334 7 Q96MG7 1 +Increased circulating lactate dehydrogenase concentration 0.3393814255524169 0.2578789555175648 0.7965003267487236 1.0 0.9262929957633468 15 Q5JRX3,Q96RL7,P23786,P10253 4 +Proximal muscle weakness 0.2862922309142763 0.2574190715205044 0.7968552818866392 1.0 0.9263047519889792 64 Q13510,O75190,Q9Y5P6,P13473,P10253,Q9BUK6,Q8NAT1,P50570,Q9H9S5,Q13126,Q9BQT8,Q99720,P12235,Q9BTV4,Q8TB36,P21912 16 +Unusual infection 0.2642281823694657 0.2573473536748804 0.7969106401088568 1.0 0.9263047519889792 220 Q13546,Q13277,Q13423,Q9Y4P3,P09601,O95202,Q13510,P16278,O95613,Q15904,Q9UBM7,Q6PGP7,Q14691,Q14739,O15360,Q96A33,P04062,Q03519,Q13315,P07602,O76024,Q8N5M9,P51798,Q03518,Q9NSD9,Q9Y487,P10253,P49327,Q9UJW0,P78527,Q8TAA9,O00203,Q9NZJ7,Q9BT22,Q9NPL8,Q9NZ08,P54802,Q13432,Q07864 39 +Heterotropia 0.2877352062913465 0.2566166720770188 0.7974747034450052 1.0 0.926498492674542 52 Q9UHX1 1 +Hypoplastic labia majora 0.3623419714119681 0.2557686273241289 0.7981295000701829 1.0 0.9267957154026668 11 Q9Y619 1 +Abnormal labia majora morphology 0.3623419714119681 0.2557686273241289 0.7981295000701829 1.0 0.9267957154026668 11 Q9Y619 1 +Central nervous system cyst 0.2863050535320572 0.2524531744463493 0.8006908034789415 1.0 0.9285528873484372 62 Q9Y5P6,Q9UHX1,Q01968,Q9Y285,Q9UBM7,Q9P2D1,Q8WVX9,Q96KP1,Q9H9S5,Q9BPU6,O43505,Q8NAT1,O95202,Q9Y487,P23786 15 +Atelectasis 0.3505808104985057 0.2522529369995256 0.8008455628568159 1.0 0.9285528873484372 13 Q13510,P21964,Q96L58 3 +Relative macrocephaly 0.2939088666717178 0.2515198634948898 0.8014122068469156 1.0 0.9285528873484372 39 Q15392,P42858,Q7Z6Z7,P55011,Q96J02,Q7LGA3,O75844,Q99575,Q9BPU6,P48651,Q07864 11 +Aplasia hypoplasia affecting the anterior segment of the eye 0.3034352078721054 0.251226600283778 0.8016389198537088 1.0 0.9285528873484372 30 Q7LGA3,O95202,Q9Y4P3,P21912 4 +Abnormal left ventricular outflow tract morphology 0.3491970802919762 0.2507064752567963 0.8020410540097458 1.0 0.9285528873484372 5 Q15645,O60566,O43683,Q06124 4 +Subvalvular aortic stenosis 0.3491970802919762 0.2507064752567963 0.8020410540097458 1.0 0.9285528873484372 5 Q15645,O60566,O43683,Q06124 4 +Aspiration pneumonia 0.3101787147487755 0.2504479687013035 0.8022409376155235 1.0 0.9285529138419836 26 P04062,P16278 2 +Irritability 0.2835877879483182 0.2496230491368034 0.8028788721240858 1.0 0.9290598355886682 76 Q13510,Q15067,P42858,Q96RL7,P07602,Q9NZJ7,P50897,O43772,Q9NZ08,P37268,P21912 11 +Cardiac arrest 0.2948646283661664 0.2476542763706521 0.8044019120529482 1.0 0.9301272482324532 38 P04062,P49748,Q9Y4P3,P0DP25,O43772 5 +Cleft upper lip 0.3020756075021119 0.2464328428927523 0.8053471850378313 1.0 0.930756970568598 31 Q96L58,O95202,Q15427,Q9P2D1 4 +Spastic tetraplegia 0.2916872442893676 0.2460687124736085 0.8056290423667873 1.0 0.9308511640975116 40 P15289,Q9P032,P16278,Q86XL3,Q96KP1 5 +Pigmentary retinopathy 0.2880171984328325 0.2455905406736208 0.8059992124623996 1.0 0.931047324987645 50 Q15067,Q7KZN9,Q16836,Q9BUK6,Q96CU9,P03886,Q15555,O76024,Q9H9S5,Q9P0J0,P00403,P21912 12 +Intellectual disability profound 0.288433029626936 0.2435700502267108 0.8075638262374243 1.0 0.9323910379470858 49 Q9H5V9,Q16625,P51812,Q9H9S5,P43034,Q01105,P31939,Q9Y487 8 +Short nose 0.2795034480486725 0.2420621984142912 0.8087319685503274 1.0 0.9330786158297744 109 Q15392,P42892,P04062,P42345,Q9UHX1,Q96L58,Q9Y4P3,O75844,P38435,Q03164,P16435,Q9Y487 12 +Abnormality of alkaline phosphatase level 0.3136832453879615 0.2407934450114646 0.8097152102921921 1.0 0.9339465906200408 24 Q8N511,Q96A33,Q96AY3,P51798,Q14739,O75845 6 +Severe viral infection 0.362149532710293 0.2369784058832043 0.8126735427594765 1.0 0.9366611956488532 6 P29144,P54132,P17812,Q9H0U3,Q7L590 5 +Lymphoproliferative disorder 0.3448288391176549 0.2346141276252791 0.8145082433214472 1.0 0.9385429807716876 5 P33991,P50851,Q9H0U3 3 +Eyelid coloboma 0.3519701923269052 0.2340877693242285 0.8149168408421028 1.0 0.9387809676549492 12 Q15427 1 +Abnormality of the supraorbital ridges 0.3101246830094318 0.2337743676886726 0.8151601498613883 1.0 0.9388284720515644 25 Q6PGP7,P51812 2 +Hyperpigmentation of the skin 0.2818284504151336 0.2333107755676788 0.8155200917826335 1.0 0.939010246944762 99 P42345,P42858,P04062,Q13423,P55011,Q13315,P51648,Q7LGA3,O75844,Q6PGP7,Q06136,Q14739,P16615,O15360,P21912 15 +Periventricular cysts 0.3605296852992964 0.2323600822717568 0.8162583502181076 1.0 0.9392125739795144 7 Q01968,O95202 2 +Anorectal anomaly 0.282004977969865 0.2320432381515887 0.8165044309735814 1.0 0.9392125739795144 76 P49748,Q9Y4P3,Q9P2D1,Q8TAA9,P28340,P51812,Q9H9S5,P48651,P16435,P16615,O15360,Q07864,P21912 13 +Abnormal location of ears 0.2653196010934427 0.2306407009816348 0.8175939451389596 1.0 0.9400003635524884 257 Q15392,Q9UHX1,P55011,Q9Y619,Q9Y4P3,Q9H9S5,Q8NAT1,O95202,P31939,P42892,Q9UM00,P16278,Q9UL01,O95613,O75381,Q9UBN7,Q15555,Q7LGA3,Q9UBM7,Q6PGP7,P16435,P43034,Q14739,P23786,P21964,P42766,P04062,Q16625,P62266,Q9P2D1,O75844,Q15427,Q9Y487,Q15067,Q13535,Q96L58,P78527,P62847,O00203,Q96KP1,Q03164,O43505,P37268,Q07864 44 +Nyctalopia 0.3006695987230936 0.2285773351342481 0.8191974421636707 1.0 0.9408691499370856 29 P38435,Q13432 2 +Abnormality of the pancreas 0.2813337503565756 0.2207689007923922 0.8252723796903896 1.0 0.945552521835154 78 P49327,P53985,Q9UJW0,Q9UHX1,Q5HYI8,P03886,Q15904,P09601,Q6PGP7,P00403,Q14739,Q9NZ08 12 +Non motor seizure 0.2849556754626132 0.2181228586662694 0.8273333875365227 1.0 0.94701823781348 50 Q13510,Q96N67,Q9H5V9,Q8WVX9,O43292,P51812,P00374,P43034,Q9NVI7,Q01105 10 +Pes planus 0.2813732117318056 0.21807973284395 0.8273669882231844 1.0 0.94701823781348 80 Q9NWM8,Q13535,Q9UHX1,Q96L58,Q9Y4P3,Q9P2D1,P51812,O15360,Q9Y487 9 +Limited hip movement 0.3369250166672022 0.2172711282277471 0.8279970559969132 1.0 0.9470518265668748 14 O75844,Q7LGA3 2 +Chromosome breakage 0.3477999083543982 0.2166116180575862 0.8285110308002204 1.0 0.9471609864906062 12 P13073 1 +Abnormality of the basal ganglia 0.2816033314433139 0.215714734712714 0.8292101149768065 1.0 0.9474938992086184 88 Q7KZN9,P04062,Q13535,P16278,P42858,Q96CU9,P03886,Q9P0J0,P00403,P23786 10 +Hyperkeratosis 0.2828266152906978 0.2149562269996948 0.8298014465557462 1.0 0.9477034220004908 60 Q9NWM8,P04062,Q9UBN7,P06280,P51648,O75844,Q06136,P16615,P42167,P21912 10 +Pneumothorax 0.3552490950721469 0.2133168475759937 0.8310798334985166 1.0 0.9485206154840096 7 Q96L58 1 +Pectus excavatum 0.2813918103270831 0.2132532316317691 0.8311294502013351 1.0 0.9485206154840096 88 P04062,Q9UHX1,Q96L58,Q9Y4P3,Q7LGA3,P51812,Q03164,Q9Y487,Q96A33,P21912 10 +Antineutrophil antibody positivity 0.3386343506991786 0.2124220047317415 0.831777820185192 1.0 0.9488066512154576 5 P49327 1 +Mild global developmental delay 0.3224547021999355 0.2124082812216457 0.8317885256996469 1.0 0.9488066512154576 18 Q96MG7,O95613,Q13535,O00203 4 +Impaired antigen specific response 0.3534121905125307 0.2107020545849467 0.8331197712713245 1.0 0.9493928028762753 9 Q96MG7,P49327,Q13546 3 +Abnormality of the small intestine 0.282374425102211 0.2099083237157553 0.833739225574363 1.0 0.9496636238151356 59 Q13277,Q9Y6B6,O15360,Q9P2D1,Q6PGP7,P51812,Q14739,O95202,Q96A33 9 +Neoplasm of the breast 0.2960500642074722 0.2094265858964218 0.8341152403502075 1.0 0.9496636238151356 32 Q13535,Q5HYI8,Q13315,P28340,Q07864,P21912 6 +Heart block 0.2973154489043351 0.2094256413208204 0.8341159776648515 1.0 0.9496636238151356 30 P49748,Q99959,P0DP25,O43772,P23786 5 +Duplication of thumb phalanx 0.3102575655381101 0.2077530338855656 0.8354218059324516 1.0 0.9506627455471864 23 P42766,P62847 2 +Abnormal blood ion concentration 0.2791206316852124 0.2075350299923999 0.8355920381592146 1.0 0.9506627455471864 73 Q13423,Q15043,P49748,Q9Y4P3,Q15904,Q9P2D1,P0DP25,P51798,Q6PGP7,Q9NSD9,Q9Y487,P21912 12 +Abnormal distal phalanx morphology of finger 0.2814447914832535 0.2059737748316452 0.8368113967151507 1.0 0.9506627455471864 53 Q96L58,Q7LGA3,O75844,P38435,P51812,P51798,P16435 7 +Abnormality of the urethra 0.2675664657061064 0.2045897680097682 0.8378926502563471 1.0 0.9506627455471864 136 Q9UHX1,P01889,Q9Y619,Q9Y4P3,O95202,O95613,O75381,Q15555,Q9UBM7,Q9UBX3,Q6PGP7,P48449,P48651,P16435,O15360,P21964,P42766,O75844,P42345,Q13535,P62847,P51970,P37268,Q07864,P51571 25 +Persistence of hemoglobin f 0.3179922841810304 0.2044013714278906 0.8380398585645059 1.0 0.9506627455471864 19 P42766 1 +Prominent metopic ridge 0.3340163934426225 0.2043166865072417 0.8381060310595598 1.0 0.9506627455471864 14 Q99741,P18074,O75845,P46821,P30153,O00330,P40763,Q00839,Q5SRE5,P61978,Q96GM5,P30566,P28482 13 +Lower limb spasticity 0.2804139554647628 0.2018952504492105 0.8399986152136396 1.0 0.951861845434773 87 Q6DKK2,P04062,P21912,Q96CU9,Q9Y619,P07602,Q9NZJ7,Q9P0J0,Q99720,Q7KZN9 10 +Aplasia hypoplasia of the clavicles 0.3489029109307936 0.2013486906678758 0.8404259324232128 1.0 0.9519195669363678 11 O75844,Q9Y619 2 +Lack of skin elasticity 0.3243633201636803 0.1970888182854618 0.843758033529421 1.0 0.9538053637316952 16 O75844 1 +Mixed hearing impairment 0.3497426567161696 0.1970777553669181 0.8437666906881764 1.0 0.9538053637316952 9 Q9NWM8,Q96L58 2 +Abnormal localization of kidney 0.2778287947800061 0.1937779520706044 0.8463497514756302 1.0 0.9559659673514648 70 P42766,Q9UHX1,Q9Y4P3,P62847,Q9UBM7,Q9P2D1,Q8TAA9,Q13426,P16435,O15360,P51571 11 +Encephalopathy 0.2753444643094213 0.1930535475217604 0.8469170319275436 1.0 0.9559659673514648 110 Q15067,Q7KZN9,P04062,Q16836,Q96CU9,Q9NVI7,P03886,Q9Y619,P07602,Q9NZJ7,Q9NPL8,P00403,O43772,O43676,Q86Y39,P23786 16 +Emg myopathic abnormalities 0.2948148009151305 0.1926711675145685 0.8472165053261835 1.0 0.9559659673514648 30 P13473,Q9BUK6,Q9Y6B6,P50570,Q9H9S5,P12235,Q9BTV4 7 +Type i transferrin isoform profile 0.3477016004032817 0.1925337697257166 0.8473241182852629 1.0 0.9559659673514648 10 Q9BT22,P51571 2 +Ocular anterior segment dysgenesis 0.2787324179547131 0.190951726781785 0.8485634135962319 1.0 0.9568994222252654 97 P42766,Q15800,P03886,Q9Y4P3,O15360,P62847,Q7LGA3,P48449,P00403,Q99797,Q9NVI7,O95202,P21912 13 +Aplasia hypoplasia involving the metacarpal bones 0.2979155279344553 0.1898132605333948 0.8494554644016852 1.0 0.9574405840878772 27 Q14739,Q96L58,P51812,P16435 4 +Corpus callosum atrophy 0.3245483870097201 0.188267794387322 0.8506667302499902 1.0 0.9576476345049836 15 O75503,P51970 2 +Abnormal cortical gyration 0.2663308013080168 0.1882639065721267 0.850669777787789 1.0 0.9576476345049836 137 Q15392,P55011,Q86XL3,Q2M389,Q9H9S5,Q13426,Q8NAT1,Q16134,O75381,P42695,P43034,Q96N66,P23786,Q9NWS8,Q16625,Q9Y5P6,Q13409,Q00535,Q96SN8,Q6ZXV5,Q01105,Q15427,Q9Y487,P42345,Q13535,P78527,Q96C86,O43505,P37268 29 +Abnormality of lower limb epiphysis morphology 0.3147246381809236 0.1876514138333159 0.8511499196846173 1.0 0.9577730340113696 19 O95831,Q6NUQ1,O95613,Q96L58,Q7LGA3,P26373 6 +Exercise induced myalgia 0.3471454849282809 0.1875958635331898 0.851193469098783 1.0 0.9577730340113696 9 P23786 1 +Aplasia hypoplasia of the humerus 0.3467760620921318 0.1862581580261915 0.8522423182952961 1.0 0.9587210195641516 9 O00116 1 +Aplasia hypoplasia of the distal phalanges of the hand 0.2865186735373341 0.183545951934255 0.8543696667050273 1.0 0.9601841972693655 38 P42345,O75844,P38435,P51798,P51812,P16435 6 +Tube feeding 0.2765408882664395 0.1824755794100624 0.855209517416291 1.0 0.9604310896582278 72 Q99720,P07602,Q9UHX1 3 +Recurrent 0.2941348117887429 0.1813672742900303 0.8560793041984052 1.0 0.9609433310717058 3 Q14683,P11182 2 +Decreased muscle mass 0.3126207174418267 0.1770189434930903 0.8594935098022618 1.0 0.9636116907676902 19 O95202,Q9Y487 2 +Duplication involving bones of the feet 0.3063924930356525 0.1757181217944246 0.8605153976932698 1.0 0.964524617052577 22 Q14739,P21964,O95202,Q9UBM7 4 +Sarcoma 0.2786655174931758 0.1752473908648782 0.8608852479438125 1.0 0.9647064307638574 61 Q15392,P42766,P62847,Q07812,Q13126,O14965,P21912 7 +Aplasia hypoplasia of the eyelid 0.3214954473094127 0.1745892453108433 0.861402399788302 1.0 0.9650531828831568 15 Q15427 1 +Mediastinal lymphadenopathy 0.3274353617365322 0.1742629064927783 0.8616588494964894 1.0 0.9651077663357496 5 O15460,Q9H0U3,P01889 3 +Ulnar deviation of finger 0.3426800973423002 0.1716129232592906 0.8637418468990286 1.0 0.9655964763743252 9 Q96L58,Q9UBM7 2 +Abnormal subarachnoid space morphology 0.2904668003616198 0.171118452890506 0.8641306265626203 1.0 0.9655964763743252 32 P03886,P51812 2 +Eclabion 0.2866311604192416 0.1675685134717169 0.8669227435023799 1.0 0.9678059352285336 36 P51812 1 +Keratoconjunctivitis 0.3400517344522088 0.1674904802172641 0.8669841374130771 1.0 0.9678059352285336 11 Q14739,P49327,Q9NZ08 3 +Posterior embryotoxon 0.313206008907181 0.166721198102988 0.8675894253075573 1.0 0.968248971890202 18 P21964,Q9Y4P3,O75381,Q7LGA3 4 +Slowly progressive 0.2773762416847544 0.1636920975832293 0.8699735388490126 1.0 0.9700065246828384 56 O14773,Q8IV08,Q9P0J0,Q99720,P12235 5 +Abnormality of the maxilla 0.2860308899664364 0.1632439118868934 0.8703263932084164 1.0 0.9700065246828384 36 Q15427,Q9Y619,P51812 3 +Feeding difficulties in infancy 0.2521096706943795 0.1631288803505444 0.8704169611284445 1.0 0.9700065246828384 181 P15289,Q9UHX1,Q9Y619,P51812,Q9H9S5,Q99720,P21912,Q9UBM7,O43681,Q9Y584,P47985,P23786,P21964,P07602,Q9P2D1,O76024,Q9Y487,P10253,Q16836,P22695,Q9NZJ7,Q9NPL8,Q9NVI7,P37268 24 +Mutism 0.3288426296059643 0.1599192759705717 0.8729446639101419 1.0 0.971711254783459 13 Q13510 1 +Abnormality of circulating enzyme level 0.2761174691903034 0.1594529439039708 0.873312029232348 1.0 0.9718341767217936 97 P53985,Q15120,Q9Y4P3,Q9H9S5,Q8NAT1,O43772,P42167,Q96RL7,P12235,Q9Y584,P47985,Q9NWM8,P23786,Q9Y5P6,P13473,Q5JRX3,Q6ZXV5,P10253,O75190,Q16836,Q9BUK6,P49748,P50402,P50570,O43505,Q9BTV4 26 +Abnormal cranial nerve morphology 0.2753859085172826 0.1554009629233105 0.8765052250848424 1.0 0.974220879364636 67 Q13510,O43819,Q9H5V9,Q9Y5P6,Q9UHX1,Q15043,O75381,Q9P2D1,P50570,P51798,P51812,Q9H9S5,P48651,P12235,P21912 15 +Keratitis 0.3321384626173109 0.1542667924181948 0.8773993796576278 1.0 0.9747715116630116 12 Q14739,P49327,Q9NZ08 3 +Abnormal circulating dicarboxylic acid concentration 0.2796212882562364 0.1540551210927915 0.877566273938786 1.0 0.9747715116630116 45 O14678,P43034,P22695,P37268,Q14739,Q9NSD9,Q16134,O75845,P23786 9 +B lymphocytopenia 0.3378122185493106 0.1539742302729932 0.8776300545170852 1.0 0.9747715116630116 8 Q13546,Q13432 2 +Preauricular skin tag 0.310479463422986 0.1536928017769993 0.8778519606956445 1.0 0.9747849448833568 18 O95202,Q15427 2 +Visual field defect 0.2797877939640522 0.1520096387261865 0.8791793333968072 1.0 0.9755593940677254 41 Q9H061,P03886,Q9Y287 3 +Abscess 0.3360981829953593 0.1503126575665853 0.880517947152438 1.0 0.9768114571323367 10 Q5HYI8,Q8TAA9 2 +Abnormal scapula morphology 0.2752149230442154 0.1471112570432741 0.8830442047172911 1.0 0.9791211048480704 54 Q9BTV4,P42766,Q9Y5P6,Q9UM00,O95613,Q9Y619,P62847,P16435,Q14739,Q15427,Q9Y487 11 +Joint hypermobility 0.2730956967914151 0.1468731490285776 0.8832321460220109 1.0 0.9791211048480704 106 Q9NWM8,P21964,P42858,Q13535,Q9UHX1,P55011,Q96L58,Q9Y619,Q9Y4P3,O95613,Q15904,Q7LGA3,P51812,Q03164,P48651,Q6ZXV5,Q9Y487 17 +Focal t2 hyperintense basal ganglia lesion 0.2990632174413677 0.145235688978156 0.8845247889228984 1.0 0.9803201739827734 23 P03886,Q9P0J0,Q7KZN9 3 +Moyamoya phenomenon 0.3339728686010643 0.1435053363682857 0.8858910970590326 1.0 0.980898483540578 6 Q5TBB1,O95613 2 +Abnormality of the nail 0.2652365763487319 0.1429074458805539 0.886363277972708 1.0 0.9811874647274724 123 P42892,Q13535,Q96L58,Q9Y619,Q9Y4P3,O75844,P51812,Q06136,P16615,O95202,Q9Y487,P23786 12 +Abnormality of the achilles tendon 0.3190786313214628 0.1409382008502643 0.8879187634190822 1.0 0.9826530026898044 14 Q9BTV4,Q9H9S5,Q15041 3 +Fat malabsorption 0.3335522973699603 0.1402428717661303 0.8884680998244094 1.0 0.9826530026898044 9 Q9Y6B6,Q14739 2 +Abnormal urine metabolite level 0.2546487339686271 0.1396057902595622 0.8889714654635243 1.0 0.9829037193106936 166 Q9Y619,Q9Y4P3,P06280,P09601,Q14108,P21912,P16278,Q6PGP7,P23786,O95470,P04062,P03886,P00403,P10253,O14678,Q16836,Q5XKP0,P49748,Q9NVI7,P54802 20 +Neurogenic bladder 0.3331284691247644 0.1388299144344804 0.8895845545816712 1.0 0.9832341371757018 9 O76024,Q9UP83,Q9BTW9,Q8TAA9 4 +Oral pharyngeal dysphagia 0.3234066934196234 0.1385183534172112 0.8898307655065603 1.0 0.9832341371757018 13 Q13510,P42858 2 +Irregular hyperpigmentation 0.2727869715087271 0.1365793143694126 0.8913633280003439 1.0 0.9843769959328732 74 P42345,P42858,P55011,Q13315,Q7LGA3,O75844,Q6PGP7,Q06136,Q14739,P16615,O15360,P21912 12 +Protruding ear 0.2755093150374255 0.1354543149119656 0.8922526826980912 1.0 0.9848909393716636 50 P27635,Q9UL01,Q01968,Q9Y4P3,Q9H9S5,P51812,O43505,Q06136,Q8NAT1 9 +Dyspareunia 0.3147703268656108 0.134334618980303 0.8931379793381065 1.0 0.9856339790985374 5 Q9P2D1 1 +Hernia 0.2617159165091216 0.1340405208110971 0.8933705325604941 1.0 0.9856564935350404 143 Q6PJG6,Q9UHX1,Q9Y4P3,P51812,Q13426,O95202,Q9UM00,P16278,Q9UL01,Q15555,Q9UBM7,Q6PGP7,P48651,Q14739,P43034,O15360,Q9NWM8,P21964,Q9P2D1,Q6ZXV5,Q9NSD9,Q9Y487,P42345,O14678,P51970 25 +Arterial stenosis 0.3114874552419318 0.131437872336104 0.8954289307320968 1.0 0.9872242079215288 15 O95613,Q9Y4P3,P21912 3 +Purpura 0.2979374252853005 0.1307753390847547 0.8959530319898641 1.0 0.9875676836595276 22 P38435,P51798,Q16625,P04062 4 +Lower limb hypertonia 0.3302266355257015 0.1300609032793663 0.8965182419828601 1.0 0.9879562979725732 10 Q14739,P21912 2 +Increased head circumference 0.2625450623708085 0.127397676123656 0.8986256554394889 1.0 0.990043821477796 134 Q15392,P42858,P55011,P78318,P51812,Q99575,Q9BPU6,P10412,Q9H9S5,Q8NAT1,Q16134,P21912,Q9UM00,Q7Z6Z7,O75381,Q9Y5W7,Q7LGA3,Q9UBN7,P49770,P48651,Q14739,Q9H5V9,P07602,Q8WVX9,O75844,P51798,Q5T2R2,P42345,P11166,P49748,Q96J02,P50570,Q9NZJ7,O43505,Q8IWS0,Q07864 36 +Facial hypotonia 0.3199045764955902 0.125117097647848 0.9004308476942999 1.0 0.9913274214188904 13 Q15907,Q9UL01,P10253 3 +Gowers sign 0.3098439843007051 0.1246092274020448 0.9008329229303268 1.0 0.991533021852668 15 Q13510,Q8NAT1,Q9Y5P6,Q9BUK6 4 +Oral ulcer 0.3278926403718232 0.1217028063121156 0.903134390646212 1.0 0.9933623056208096 9 P49327,Q13546,Q9NZ08 3 +Abnormality of the upper arm 0.2972869701186825 0.1205942330709135 0.9040124368482968 1.0 0.9940927293721152 21 O15228,O00116,P48651,P16435,Q9BTV4 5 +Abnormality of the skull base 0.2715709466372866 0.1200055862908989 0.9044787227217508 1.0 0.9941426385643046 68 Q9UHX1,P49748,Q96L58,Q9UBM7,Q9P2D1,Q9H9S5,Q9NPL8,O43505,Q14739,Q9Y487,P23786 11 +Hypertensive crisis 0.3091061346408024 0.11763985905784 0.9063530212488456 1.0 0.9952531639617436 5 P21964 1 +Abnormal finger phalanx morphology 0.248749939778248 0.1160825962118677 0.907587081769642 1.0 0.9959408423431212 178 P42858,Q9UHX1,P55011,Q9Y619,P38435,P51812,O95202,O95613,Q7LGA3,Q9UBM7,P48651,P16435,Q14739,O15360,P21964,P42766,Q9P2D1,O76024,O75844,P51798,Q15427,Q15067,P42345,Q13535,Q96L58,P62847,Q03164 27 +Abnormal circulating amino acid concentration 0.2719845376696121 0.1160380713308542 0.9076223690229824 1.0 0.9959408423431212 55 P05067,O14678,Q5XKP0,P03886,Q9Y619,P22695,Q6PGP7,Q9P0J0,Q99797 9 +Abnormal electroretinogram 0.2819954781134134 0.1150601172004854 0.908397471755702 1.0 0.9961605477350352 32 P50897,O14773 2 +Reduced tendon reflexes 0.2484366135793172 0.1149738757526531 0.9084658288319724 1.0 0.9961605477350352 177 P15289,Q9H9S5,Q9BQT8,Q8NAT1,Q99720,Q13510,O43819,Q96RL7,Q15041,Q9Y6B6,Q92974,Q9NR77,O75381,O43681,P12235,Q9NWS8,P04062,Q9Y5P6,O15269,P03886,Q13315,P07602,Q00535,Q8TB36,P10253,Q15067,Q9BUK6,Q96AY3,Q8TAA9,P50570,Q9NZJ7,Q9BT22,O43505,P54802,Q9BTV4 35 +Hip subluxation 0.3251887371704804 0.1137972594355884 0.9093985111350622 1.0 0.9969479666667056 8 Q96L58 1 +Aplasia hypoplasia of the nipples 0.3032190178295731 0.1109635896332894 0.911645219640388 1.0 0.9991752041635392 17 O95202 1 +Athetosis 0.304675482897572 0.1096626674367859 0.9126769088615624 1.0 1.0 16 O14949 1 +Peripheral pulmonary artery stenosis 0.3239233165739741 0.1091914304092356 0.9130506572113212 1.0 1.0 10 Q9Y4P3 1 +Decreased circulating cortisol level 0.3234411936177302 0.1085115771461235 0.9135898975067752 1.0 1.0 8 Q13423 1 +Cerebellar dysplasia 0.3215537383177624 0.1073742129949875 0.9144921112662704 1.0 1.0 6 P63000,Q7Z3E5,Q8NI27,P60953,Q9H9S5 5 +Areflexia 0.2721699063281371 0.1072652071163798 0.9145785859501976 1.0 1.0 89 Q15120,Q9H9S5,Q9BQT8,Q8NAT1,Q13510,O43819,Q96RL7,Q15041,Q9Y6B6,Q9NR77,P12235,Q9NWS8,Q9Y5P6,O15269,Q00535,Q5T2R2,Q8TB36,P10253,Q15067,P50570,Q9BT22,O43505 22 +Hyposmia 0.2999886320827025 0.1055709148993534 0.915922802308192 1.0 1.0 18 Q15043,P04062,Q9P2D1 3 +Hyperactive deep tendon reflexes 0.3224071724230156 0.1054163895178688 0.9160454115687452 1.0 1.0 8 Q9NR77,P21912 2 +Abnormal tracheal morphology 0.2736353313302491 0.1046197515650975 0.9166775412321352 1.0 1.0 42 O95613,P55011,Q9Y4P3,Q96L58,Q9P2D1,Q14739,Q96HY6,O15360 8 +Gastrostomy tube feeding in infancy 0.2792268158574557 0.1045715631566278 0.916715780273748 1.0 1.0 34 Q99720 1 +Abnormal connection of the cardiac segments 0.2710735738671161 0.1024801585329747 0.9183755611212916 1.0 1.0 60 Q9UHX1,Q9Y4P3,O75844,Q6PGP7,O15360,Q15427 6 +Abnormality of the coagulation cascade 0.2742797195840544 0.1018994161131758 0.9188365134255954 1.0 1.0 39 Q16836,Q5XKP0,Q9Y619,P38435,Q9Y487 5 +Abnormally folded helix 0.2969502701286249 0.1018558713121526 0.918871077313568 1.0 1.0 19 P21964,Q9P2D1,P23786 3 +Retinal atrophy 0.2798914293321401 0.1015544672419934 0.9191103223929222 1.0 1.0 32 P42858,P04062,P55011,P51648,Q7LGA3 5 +Cns hypomyelination 0.2728607788600703 0.1003276913276355 0.9200841738985096 1.0 1.0 40 Q9NWS8,Q96KP1,P49770,Q99720,Q8TB36 5 +Abnormal penis morphology 0.2531422534961976 0.0985642114742175 0.921484286715389 1.0 1.0 203 Q9UHX1,Q9Y619,Q9Y4P3,Q9H9S5,Q13426,Q9BPU6,Q8NAT1,O95202,P21912,P42892,O95613,O75381,Q15555,Q9UBM7,Q9UBX3,Q6PGP7,P48449,P48651,P16435,P43034,O15360,O95470,P27635,P21964,P42766,Q9P2D1,O75844,O75845,P42345,Q13535,P78527,P62847,P51970,O43505,Q9NVI7,P37268,Q07864,P51571 38 +Triangular face 0.2722727328434929 0.0945154036026653 0.924699746914043 1.0 1.0 44 Q13426 1 +Genu varum 0.3192942328914499 0.0944563202767131 0.9247466786260884 1.0 1.0 10 Q96HY6,Q9Y619,P26373 3 +Hydroureter 0.3069304801483277 0.093606759260252 0.925421540080558 1.0 1.0 14 O15360,Q7LGA3 2 +Inflammatory abnormality of the eye 0.2719054197119921 0.0933022295922465 0.9256634608531422 1.0 1.0 40 P49327,Q15800,P01889,P02786,P50851,Q9NZ08,P51648,Q9BUR4,Q14739,P04439 10 +Dysgraphia 0.3111334570770715 0.092933911471535 0.9259560648585216 1.0 1.0 13 P05067 1 +Focal dystonia 0.2886812761503316 0.0908106054907917 0.927643082910377 1.0 1.0 23 Q99720,Q96L58,Q96RL7 3 +Abnormality of the palm 0.2601693989165714 0.0890829859550583 0.9290159588712564 1.0 1.0 125 Q9UHX1,Q9Y619,P51812,Q9BPU6,O95202,P42167,P21912,Q9UL01,O75381,Q9UBN7,Q15555,P48651,P16435,Q14739,P62266,Q9P2D1,Q06136,Q9Y487,P42345,Q13535,Q15907,P16615 22 +Synostosis involving bones of the hand 0.3138825425821477 0.0887849086093739 0.9292528515064182 1.0 1.0 12 Q96L58,P16435 2 +Paroxysmal ventricular tachycardia 0.3153160190616639 0.0873219310492839 0.9304156221465878 1.0 1.0 7 Q9HD47,Q99959 2 +Cortical dysplasia 0.2781815816499581 0.0867029990713238 0.930907592483287 1.0 1.0 30 P42345,P55011,Q2M389,Q96C86,O43505,Q9NZ01,Q96N66 7 +Long eyelashes 0.2721326201095604 0.0864397497864928 0.9311168494028812 1.0 1.0 39 Q9UM00,Q9UHX1,Q92974,Q9Y619,P62266,Q03164 6 +Tremor by anatomical site 0.2782994917151767 0.0860220148357616 0.9314489167827882 1.0 1.0 28 Q99720,Q96RL7 2 +Aplasia hypoplasia involving bones of the feet 0.267874027941427 0.0846972532046785 0.932502079747396 1.0 1.0 74 Q13510,P42858,Q9UHX1,P55011,Q9UBN7,Q7LGA3,Q9P2D1,P13073,Q03164,O95202,Q15427,Q96A33 12 +Tonic seizure 0.2823265289975624 0.0843164725299896 0.93280481585342 1.0 1.0 26 P27635,P07602,Q9NZJ7,P43034,Q01105 5 +Petechiae 0.3086316547656166 0.084126494245665 0.932955859944686 1.0 1.0 13 Q16625,P04062 2 +Abnormal circulating androgen level 0.3041294128572968 0.0832670245077137 0.933639219843028 1.0 1.0 14 Q13423,P16435 2 +Long philtrum 0.2584441201249631 0.0797354532332776 0.9364476616074944 1.0 1.0 141 P42858,Q6PJG6,Q9UHX1,P55011,Q9Y4P3,P51812,Q9BPU6,Q2TAA5,P16278,Q9UL01,Q92974,Q15555,Q7LGA3,Q9UBM7,Q6PGP7,P16435,P27635,P21964,Q9H5V9,Q16625,Q8WVX9,Q9Y487,O75845,P42345,Q96L58,P78527,O00203,Q96KP1,Q03164 29 +Patent ductus arteriosus 0.2696847936006411 0.0795632485425431 0.9365846259294512 1.0 1.0 93 Q9NWM8,P42892,Q15392,P21964,Q9UHX1,O95613,Q9Y4P3,Q9P2D1,P0DP25,O75844,Q9UBM7,Q6PGP7,O15360,Q15427,P51571 15 +Exertional dyspnea 0.2939339945481588 0.0793290900789758 0.9367708686699054 1.0 1.0 18 O75844 1 +Orofacial dyskinesia 0.2946265900726533 0.0783614898316287 0.9375405059607972 1.0 1.0 5 Q96RL7 1 +Dilated fourth ventricle 0.2697205554460264 0.0782383191914901 0.9376384811153288 1.0 1.0 47 Q9Y5P6,Q9UBM7,Q9P2D1,Q96KP1,Q9H9S5,Q9BPU6,O43505,Q8NAT1,Q9Y487,P23786 10 +Cutaneous syndactyly of toes 0.2786764963414252 0.077639362703831 0.938114929957118 1.0 1.0 4 P27635 1 +First degree atrioventricular block 0.3088362964138315 0.0738367622548018 0.941140274800038 1.0 1.0 6 Q9HD47,Q99959 2 +Myotonia 0.3108247703537785 0.0724184708820144 0.942268885749542 1.0 1.0 8 O75190,Q9BTV4 2 +Sparse and thin eyebrow 0.3121178684123461 0.0722313524063814 0.942417794718888 1.0 1.0 11 Q96EK5,Q9UM00,P48449 3 +Increased circulating igg level 0.2755399883245838 0.0698161779835953 0.9443399704296824 1.0 1.0 4 P49327,P29144,O95394 3 +Chronic kidney disease 0.2707239970884986 0.0692029508135273 0.9448280743314572 1.0 1.0 38 P23786 1 +X linked dominant inheritance 0.2843092958902045 0.0690121420456761 0.944979954588902 1.0 1.0 23 P51812 1 +Severe postnatal growth retardation 0.3072635120205558 0.0671166059673104 0.9464888740535096 1.0 1.0 12 O76024,O95202 2 +Short palm 0.2809342855467507 0.0671003533467869 0.9465018126009856 1.0 1.0 25 Q9Y619,Q9UBN7,Q9UHX1 3 +Back pain 0.282042119354162 0.0646776550926009 0.9484306542165292 1.0 1.0 24 P01889,Q5HYI8,Q8TAA9,Q8WVX9,P51798,Q9BTV4 6 +Demyelinating peripheral neuropathy 0.2916128541991183 0.0629070081510918 0.949840554202516 1.0 1.0 17 P03886 1 +Abnormality of the tonsils 0.304254194667079 0.0626347708396748 0.9500573406392364 1.0 1.0 6 P21964 1 +Abnormal hemoglobin 0.2823760803672241 0.0595962910575333 0.9524771724273908 1.0 1.0 23 P42766 1 +Abnormality of the pulmonary vasculature 0.267307327749643 0.0578658267623874 0.9538555037838734 1.0 1.0 46 Q15392,P42858,Q9Y4P3,Q7LGA3,P51798,Q6PGP7 6 +Abnormal lung development 0.2671213789184277 0.0577600183012197 0.953939785754397 1.0 1.0 47 Q9UHX1,Q96L58,Q9UBM7,Q8TAA9,O75844,Q14739,O95202 7 +Multiple joint contractures 0.282650785775428 0.0554967824573886 0.955742693228766 1.0 1.0 22 Q9Y5P6,Q5TBB1,Q96L58,P35251,O75844,Q9H9S5,Q15043 7 +Lower limb hyperreflexia 0.2839651513450895 0.0540241106019169 0.9569159548065104 1.0 1.0 20 Q14739,P13073,P21912 3 +Coarse facial features 0.2643248471834299 0.0538840706460524 0.9570275280096096 1.0 1.0 70 P16278,Q9Y4P3,Q7LGA3,P10619,P51812,P54802 6 +Abnormality of urine homeostasis 0.2503197617589262 0.0538394661253391 0.9570630656816266 1.0 1.0 201 Q13423,Q9Y619,Q9Y4P3,P06280,P09601,Q9H9S5,Q14108,O43772,P21912,P16278,Q6PGP7,P12235,P23786,O95470,P04062,P03886,P00403,P10253,O14678,Q16836,Q5XKP0,P49748,Q9NVI7,P54802 24 +Atonic seizure 0.2798436455174149 0.0537198401885743 0.957158375440002 1.0 1.0 24 Q13510,Q96N67,P11166,O43292,Q96T60,P43034,Q01105 7 +Aortic arch aneurysm 0.3039999820930494 0.0515941637859851 0.9588520697721978 1.0 1.0 9 Q9Y4P3 1 +Hodgkin lymphoma 0.3044714466722731 0.0494754829105983 0.9605403750693168 1.0 1.0 11 Q13315,Q07864 2 +Sleep apnea 0.2713609357968842 0.0464932566570584 0.9629171086842 1.0 1.0 28 P51812,Q96A33 2 +Increased mean corpuscular volume 0.2811268225425944 0.0445585788224427 0.9644591591560252 1.0 1.0 21 P42766 1 +Lactic acidosis 0.2665229241683847 0.0434095904671399 0.9653750328218568 1.0 1.0 91 Q70HW3,Q9NWS8,Q16836,Q5XKP0,Q9P032,Q96CU9,P03886,Q9NPL8,P00403,Q99797,Q6P4A7,O43676,P12235,Q86Y39,P47985 15 +Ventricular escape rhythm 0.2781374453395442 0.0397442238682305 0.9682970439632465 1.0 1.0 5 Q9BTV4 1 +Hemiplegia hemiparesis 0.2645323435846252 0.0374278364706435 0.970143877921491 1.0 1.0 42 P49327,P42345,Q9Y5P6,P01889,P03886,Q9H9S5,P00403,Q9NZ08 8 +Abnormal urinary electrolyte concentration 0.281973563247874 0.0373347933987059 0.9702180637017204 1.0 1.0 19 Q13423 1 +Generalized hypopigmentation 0.2994476229903983 0.0371940751634021 0.9703302626800636 1.0 1.0 10 Q01968,Q6PGP7,O00203 3 +Multifactorial inheritance 0.2865930997352628 0.0364392483770701 0.9709321192681788 1.0 1.0 15 Q07812,P42892 2 +Abnormal levels of alpha fetoprotein 0.2964997291241397 0.0359612070785889 0.97131329119958 1.0 1.0 8 Q01968,Q13315 2 +Scrotal hypoplasia 0.2814520597726144 0.0352272562389457 0.9718985283794166 1.0 1.0 19 P18074,Q8TCJ2,Q9H2M9,P46977,Q6NUK1,Q9UBM7,Q15555,P07437,P16435,Q8IWS0 10 +Elevated circulating alanine aminotransferase concentration 0.2967113055961332 0.0349783886938884 0.9720969736501804 1.0 1.0 12 Q15904,Q96RL7,P10253 3 +Torsion dystonia 0.2594820976419356 0.0337564859895569 0.9730713353028642 1.0 1.0 4 P11166 1 +Carious teeth 0.264123458930125 0.0335664627808794 0.9732228660133764 1.0 1.0 46 Q13535,P16278,Q96L58,Q9Y4P3,Q9Y487 5 +Skin rash 0.2773881809076148 0.0315262990611935 0.97484981894788 1.0 1.0 22 Q06136,P21912 2 +Abnormal reflex 0.2391632870961655 0.0304058111616791 0.9757434103631528 1.0 1.0 373 P15289,P42858,Q6PJG6,Q9P032,P01889,Q96CU9,Q96IX5,P55011,Q9Y619,Q9Y4P3,Q86XL3,P51812,Q9H9S5,Q9P0J0,Q9BQT8,Q99720,Q6DKK2,Q8NAT1,Q2TAA5,P21912,Q13510,Q15043,O43819,Q96RL7,P49902,Q15041,Q9Y6B6,Q92974,Q9NR77,O75381,Q15555,O43292,P13073,P42695,Q14739,O43681,P12235,O15360,Q96N66,Q9NWS8,Q16625,P04062,Q9H5V9,O15269,Q9Y5P6,P03886,Q13315,P07602,Q13409,Q00535,Q8WVX9,O14949,Q5JRX3,Q5T2R2,Q96SN8,Q8TB36,P10253,Q15067,P49327,O75569,P11166,Q5XKP0,Q9BUK6,P17900,Q96AY3,O14773,Q8TAA9,P50570,Q9NZJ7,O75503,Q9BT22,O43505,Q9NZ08,P54802,Q9BTV4,Q7KZN9 76 +Abnormal stomach morphology 0.2641483830457591 0.0283979773561186 0.9773447373880972 1.0 1.0 81 P49327,Q13546,Q9H5V9,P04062,P11802,Q9Y4P3,O75381,Q9UBM7,Q07812,O76024,P50570,P51812,Q6PGP7,Q6ZXV5,Q14739,O14965,P21912 17 +Abnormality of t cell physiology 0.2910580732357887 0.0271377566457598 0.9783498603926276 1.0 1.0 13 Q96MG7,P21964 2 +Abnormal internal genitalia 0.2551913489719928 0.0198471072793879 0.9841653390977256 1.0 1.0 131 Q16740,Q5HYI8,Q9Y4P3,P51812,O95202,P21912,Q9UBM7,P49770,P16435,O15360,P21964,Q13315,Q9P2D1,O75844,Q15427,O14965,Q07812,P28340,Q07864 19 +Abnormal caudate nucleus morphology 0.2924719583114748 0.0194137917455089 0.9845110082604512 1.0 1.0 10 P42858,Q96RL7 2 +Aortic dissection 0.2507297139521376 0.0168989581778278 0.9865172239027984 1.0 1.0 4 O15460,P31153,P01889 3 +Abnormal circulating methionine concentration 0.2878118294304358 0.0162421682117285 0.9870411945252238 1.0 1.0 8 Q99707,Q6PGP7 2 +Achilles tendon contracture 0.2899744416828588 0.0160460093311922 0.9871976862725408 1.0 1.0 12 P50402,Q9H9S5,Q9BTV4,Q08J23 4 +Horseshoe kidney 0.261762728448329 0.0158818354020629 0.9873286614253688 1.0 1.0 46 P42766,Q9UHX1,P62847,Q9P2D1,P16435,O15360 6 +Abnormality of the sense of smell 0.2736798744717578 0.0152722260769851 0.9878150002792858 1.0 1.0 22 P42858,P04062,Q9P2D1,Q15043 4 +Decreased facial expression 0.2653614818826179 0.0139723593345064 0.9888520329405576 1.0 1.0 28 P04062,Q9BUK6,O75165,Q9H9S5,P12235,Q15043 6 +Uveitis 0.2882993445232253 0.0130472036052908 0.9895901330269712 1.0 1.0 9 P49327,P01889 2 +Skin pit 0.2830717673764099 0.012866496178909 0.9897343045900416 1.0 1.0 14 O95202 1 +Abnormal blistering of the skin 0.2721335725496167 0.0120979672738509 0.9903474541547452 1.0 1.0 23 Q9H1A4,P49327,P01889,P51798,Q06136,Q9H4L7,Q9NZ08 7 +Cough 0.2648004822051864 0.011013531813997 0.991212650653872 1.0 1.0 28 Q9NSD9,Q9NR77,P04062,O15269 4 +Abnormal nipple morphology 0.2610774090894094 0.0106243020079768 0.991523192929882 1.0 1.0 64 Q15067,O14678,Q92974,Q7LGA3,Q9P2D1,Q96KP1,O95202,Q2TAA5,Q96A33,P23786 10 +Aplasia hypoplasia of the eyebrow 0.2608524866992881 0.0101740089597326 0.991882455371595 1.0 1.0 43 Q92643,Q9UM00,O95613,P46778,Q9P2D1,O75844,Q96EK5,P48449,Q9NVI7,Q15427 10 +Abnormality of the nasal alae 0.2424371427801131 0.0088253270438859 0.9929584992139542 1.0 1.0 177 Q15392,P04062,P16278,Q9UHX1,Q7LGA3,P51812,Q13426,P31939,Q9Y487 9 +Lymphocytosis 0.2618134445573439 0.0079739307238792 0.9936377912085692 1.0 1.0 5 P49327 1 +Dysphonia 0.2626069283071456 0.005914901932168 0.9952806185884402 1.0 1.0 36 Q6DKK2,Q9Y4P3,Q13510,P21912 4 +Abnormality of the musculature of the upper limbs 0.2607581794320104 0.0055611999172917 0.995562827317832 1.0 1.0 76 O75190,Q9BTV4,P42766,Q9Y5P6,P50402,Q9NR77,P07602,P62847,P50570,Q9H9S5,Q9NZJ7,Q9BQT8,P12235,Q9Y487,Q8TB36 15 +Abnormal exteroceptive sensation 0.2592572287368245 0.0030506213071878 0.9975659601334528 1.0 1.0 56 P05067,P49327,Q9UL01,O15269,P01889,Q9NR77,P07602,P06280,Q8WVX9,Q9NZJ7,Q9NZ08,P54802 12 +Primary amenorrhea 0.2634708215389084 0.0020952779663679 0.9983282112832896 1.0 1.0 31 P49770,P16435,Q9P2D1,Q16740 4 +Duodenal atresia 0.2829581993569076 0.0013247716822029 0.9989429854373616 1.0 1.0 9 O60566,Q7LBC6,Q9P2D1,Q15645,O43683,O43684,Q8N3U4,P49454 8 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..da5f422539a8ef9270a3eb8472716bf3f4c74701 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 4th finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal bowel sounds", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal coronary sinus morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger flexion creases", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemidiaphragm morphology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lacrimal punctum morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mast cell morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal right ventricular function", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the dental root", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal tarsal ossification", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of masticatory muscle", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanges of the toes", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent lacrimal punctum", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent tibia", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Acetabular spurs", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acromicria", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Acute rhabdomyolysis", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anaphylactic shock", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lens", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the middle phalanges of the toes", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar impression", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonate wasting renal tubular acidosis", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid epiglottis", "Bifid nasal tip", "Bifid nose", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of cartilage", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cephalohematoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical cord compression", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal dystrophy", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Choroideremia", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic myelogenous leukemia", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clinodactyly of the 2nd finger", "Clinodactyly of the 3rd finger", "Clinodactyly of the 4th finger", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystathioninemia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dacryocystitis", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased csf homovanillic acid", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to anti cd3", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased nasal nitric oxide", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum complement c4", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatochalasis", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the 4th finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Discoid lupus rash", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal symphalangism", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Dumbbell shaped long bone", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of phalanx of hallux", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgenesis of the hippocampus", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Eeg with spike wave complexes 2 5 3 5 hz", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated total serum tryptase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg myotonic discharges", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic aura", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial paralysis", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal motor status epilepticus", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal sensory seizure", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Ganglioneuroblastoma", "Ganglioneuroma", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked horizontal nystagmus", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu recurvatum", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonadotropin deficiency", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Halitosis", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematemesis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemolytic uremic syndrome", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hypereosinophilia", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensibility of the knee", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypoglycorrhachia", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the primary teeth", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic iris stroma", "Hypoplastic ischia", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile cilia", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired renal concentrating ability", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased fibular diameter", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intervertebral space", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proportion of cd25 mast cells", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urinary potassium", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Increased vldl cholesterol concentration", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "Ivory epiphyses", "Ivory epiphyses of the phalanges of the hand", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Kinked brainstem", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Knee pain", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens luxation", "Lens subluxation", "Lenticonus", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited knee extension", "Limited wrist extension", "Limited wrist movement", "Linear arrays of macular hyperkeratoses in flexural areas", "Lingual dystonia", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Lobar holoprosencephaly", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Long upper lip", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low self esteem", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lupus anticoagulant", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Malar rash", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Meningoencephalocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal spurs", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microangiopathic hemolytic anemia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Miosis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Motor tics", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic absence seizure", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuroma", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve compression", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthokeratosis", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Oxycephaly", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary cystadenoma of the epididymis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid dysgenesis", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dyskinesia", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Percussion myotonia", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Personality disorder", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Popliteal pterygium", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior rib cupping", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent calcaneus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protracted diarrhea", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent thrombophlebitis", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal sodium wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocerebellar cyst", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of finger phalanx", "Sclerosis of hand bone", "Sclerosis of skull base", "Sclerotic vertebral endplates", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe platyspondyly", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Silver gray hair", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skewfoot", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small forehead", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hematomas", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous pneumothorax", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Spotty hypopigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary cusp", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Swan neck like deformities of the fingers", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic dysplasia", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thrombophlebitis", "Thymus hyperplasia", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tibialis muscle weakness", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "True hermaphroditism", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Uncontrolled eye movements", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral atresia", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Yellow white lesions of the retina", "Young adult onset", "Zollinger ellison syndrome", "Zonular cataract"], "available_proteins": ["AAAS", "AAGAB", "AARS", "AARS2", "AASS", "ABAT", "ABCB1", "ABCB7", "ABCD3", "ABCD4", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACY1", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AGTPBP1", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP10", "AKAP9", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG11", "ALG2", "AMPD2", "ANAPC1", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANXA11", "AP1B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARID1A", "ARID2", "ARL2", "ARL3", "ARL6IP1", "ARMC9", "ARPC1B", "ARSA", "ARVCF", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATG7", "ATIC", "ATL3", "ATM", "ATP1A1", "ATP2A2", "ATP2B4", "ATP5A1", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATR", "ATXN10", "AURKA", "B3GALT6", "B4GAT1", "BAG3", "BANF1", "BARD1", "BAX", "BAZ1B", "BCAP31", "BCAT2", "BCKDHB", "BCKDK", "BCR", "BCS1L", "BICD2", "BLM", "BLVRA", "BMS1", "BPTF", "BRAT1", "BRCA1", "BRD4", "BUB1", "BUB1B", "BUB3", "BUD23", "C19orf70", "C1QBP", "C21orf59", "CAD", "CALD1", "CALM3", "CALR", "CAMK2G", "CAPN1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBL", "CC2D1A", "CCDC115", "CCDC22", "CCDC47", "CCT5", "CD109", "CD2AP", "CD3EAP", "CDC40", "CDC42", "CDC6", "CDC73", "CDH2", "CDK13", "CDK4", "CDK5", "CDK5RAP2", "CELF2", "CENPF", "CEP250", "CEP290", "CEP55", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD7", "CHD8", "CHEK2", "CHM", "CHORDC1", "CHUK", "CISD2", "CIT", "CIZ1", "CLASP1", "CLCC1", "CLCN7", "CLIP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "CNP", "COA3", "COA7", "COASY", "COG5", "COG7", "COG8", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ8A", "COX15", "COX2", "COX4I1", "COX5A", "COX6B1", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CREBBP", "CRKL", "CRTAP", "CSNK2A1", "CSNK2B", "CSTB", "CTBP1", "CTDP1", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CUL3", "CUL4B", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "DARS", "DARS2", "DAXX", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DKC1", "DLAT", "DLD", "DLST", "DNAAF2", "DNAAF5", "DNAJB11", "DNAJB6", "DNAJC13", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPH1", "DPM1", "DPP9", "DPYSL5", "DSC2", "DSE", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHHADH", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELMO2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERLIN1", "ERLIN2", "ESS2", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXOC2", "EXOC6B", "EXOC7", "EXOC8", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FAH", "FAM126A", "FAM50A", "FANCA", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FUCA1", "FUS", "FXR1", "FYCO1", "G6PD", "GAA", "GALE", "GALK1", "GALNT2", "GAMT", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GBA", "GBE1", "GCDH", "GCLC", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GINS1", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GNAI2", "GNAI3", "GNB1", "GNE", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPT2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2E2", "GTF2I", "GTPBP3", "GUF1", "GUSB", "GYG1", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HARS2", "HCCS", "HCFC1", "HDAC6", "HELLS", "HERC2", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS5", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IFT52", "IGBP1", "IGF2BP2", "IGF2R", "IKBKB", "INF2", "INPPL1", "INTS1", "INTS8", "IRAK1", "IRF2BPL", "IRS4", "ISCA2", "ITCH", "ITGA6", "ITM2B", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KATNB1", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KLC2", "KMT2A", "KNSTRN", "L2HGDH", "LAMB1", "LAMC1", "LAMP2", "LAMTOR2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD2", "LEMD3", "LETM1", "LIN28B", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LSS", "LZTFL1", "MACF1", "MAGED2", "MAGT1", "MAN2B1", "MAP1B", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPKAPK3", "MAPRE2", "MARS", "MARS2", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MECR", "MED17", "MED23", "MESD", "MGME1", "MIA3", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMACHC", "MOCS1", "MOCS2", "MOGS", "MORC2", "MPDZ", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTHFR", "MTMR2", "MTO1", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MVD", "MYH14", "MYH9", "MYO1E", "MYO5A", "MYO6", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCDN", "NCSTN", "ND1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEMF", "NEU1", "NF1", "NHLRC2", "NHP2", "NIPBL", "NNT", "NONO", "NOP56", "NOTCH2", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NUBPL", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OSBPL2", "OTULIN", "OXCT1", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PARS2", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PCNT", "PDCD6", "PDHA1", "PDHB", "PDHX", "PDK3", "PDSS1", "PDSS2", "PEPD", "PEX14", "PEX19", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PISD", "PITRM1", "PKN1", "PKP2", "PLAA", "PLCG2", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNP", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "POLR3B", "POMGNT2", "POMP", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCA", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PRUNE1", "PSAP", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PSMG2", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QRICH1", "QRSL1", "RAB11B", "RAB18", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RABL3", "RAC1", "RAD21", "RAD50", "RAF1", "RALA", "RANBP2", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RB1", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "RELA", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RMND1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF2", "RNF213", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS28", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RRP7A", "SACS", "SALL2", "SAMHD1", "SAR1B", "SARS", "SARS2", "SATB2", "SBDS", "SC5D", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCYL1", "SCYL2", "SDHA", "SDHB", "SEC23A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SELENBP1", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SLC12A2", "SLC16A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC2A1", "SLC39A14", "SLMAP", "SLTM", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMG8", "SMN1*", "SMPD4", "SMS", "SNRNP200", "SNRPE", "SNX14", "SOAT1", "SON", "SORD", "SPART", "SPATA5", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SRA1", "SRCAP", "SRP54", "SRP72", "SSBP1", "SSR4", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK4", "STT3A", "STT3B", "STUB1", "STX3", "SUCLA2", "SUCLG1", "SUZ12", "SYNE2", "TAF15", "TAF6", "TALDO1", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARDBP", "TARS", "TARS2", "TBCD", "TBCE", "TBL2", "TCF20", "TCOF1", "TDP2", "TECR", "TELO2", "TENM3", "TERF2IP", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM22", "TIMM50", "TIMMDC1", "TJP2", "TKFC", "TKT", "TMCO1", "TMEM126A", "TMEM199", "TMEM43", "TMLHE", "TMPO", "TMPO", "TMTC3", "TMX2", "TNPO3", "TNRC6A", "TOE1", "TOMM40", "TONSL", "TOP2A", "TOR1A", "TOR1AIP1", "TP53", "TPI1", "TPM1", "TPM3", "TPP1", "TPP2", "TPRKB", "TRAPPC11", "TRAPPC4", "TRIM28", "TRIO", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRRAP", "TSFM", "TSPYL1", "TTC19", "TTC37", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", 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sha256:6f7ae1195bca762a34578f6fc54173f102152f585b554b4ffb44337611f0267b +size 141093 diff --git a/msigdb_kegg/consensus.joblib b/msigdb_kegg/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0f8e6236df0e4cafed006c8ec109685fa5abe965 --- /dev/null +++ b/msigdb_kegg/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5fd6fd030e9b184928cd3a18e54c05090c11968f9660379e29971682f3641b95 +size 98438 diff --git a/msigdb_kegg/df_merge.tsv b/msigdb_kegg/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3becd6157a14d230ecaa19a6e4161a536d0ff769 --- /dev/null +++ b/msigdb_kegg/df_merge.tsv @@ -0,0 +1,15 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lysosome 23 50 3.888330541960108 0.0001009361048358 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 0.0012443166286677 0.0846927074460255 4.418300680293524e-05 1.9469379794185524e-11 5.446756819932193e-12 +Nicotinate and nicotinamide metabolism 2 5 2.831752403386201 0.0046293680377074 1.577669902912621 5.555825242718447 0.8765246600520394 0.3422223651000359 1.128314495064996 0.9700815942780172 0.9601213388242128 0.2885413402242885 1.0 1.0 1.0 0.0498779046475234 0.0338099842169397 +Parkinsons disease 15 55 2.789047505176507 0.0052863310276958 16.90776699029126 54.04126213592233 1.0315348591123816 0.3152611195514452 7.595108151251147 4.223805209268991 1.8494970521239744 0.3626807692210581 0.0014849208064248 0.0015835716265251 5.699557697064118e-05 1.676164402647137e-07 9.278866536151362e-08 +Calcium signaling pathway 7 19 2.719598888321769 0.0065361148231086 5.735436893203883 16.946601941747574 1.0005800740695592 0.3113014190776675 2.984654368989517 2.3866666657890168 1.2450167285670062 0.3187454651207294 0.098079111708626 0.0402962873689797 0.1290920553826253 0.0723728978816966 0.0040466728259346 +Sphingolipid metabolism 8 12 2.7028638931498765 0.0068744889783787 5.672330097087379 11.759708737864075 0.9805985471070467 0.1821702203806468 2.452838935293596 1.3449033287601222 1.7625559835482287 0.2542774311591588 4.533849025767395e-05 0.1157751708195439 8.694316847855437e-05 0.0002861885476851 1.4660824937382194e-06 +Cardiac muscle contraction 7 21 2.6134710558876977 0.0089627675032877 7.728155339805825 19.856796116504853 1.0644813600437804 0.240240383706381 3.4195161605095614 1.765741250102918 1.6465694074711887 0.3002212677564749 0.0517352073763297 0.1988423464133734 0.0091243340822671 9.297701577536192e-05 0.0002658988531176 +Oxidative phosphorylation 15 61 2.446611848884541 0.0144206045919825 18.79854368932039 59.0752427184466 1.0149760730411637 0.3252836463038503 7.263801581344288 4.652138947381941 1.8018345229041028 0.3643612228552857 0.0098095354399013 0.0139189683537814 5.699557697064118e-05 1.676164402647137e-07 1.7941487861113353e-08 +Steroid biosynthesis 8 13 2.387676481718566 0.0169552599323516 4.451456310679611 10.919902912621358 0.8535439655720318 0.1867209176898754 2.1463612955879627 1.3314318120676296 1.5430058140543457 0.1933818217769055 0.1081933924999157 0.066549445548378 0.1265462710440741 4.854640979129953e-07 2.328477048209561e-09 +Riboflavin metabolism 1 6 2.3328808526788607 0.019654399582786 1.2597087378640777 5.470873786407767 0.8651682051380694 0.3242718261444057 1.1073575266667028 1.2430881579904736 0.9666566709677474 0.2578857718572043 0.0860283086388496 0.0526645480715484 0.1008375048293403 0.027832231049335 0.0974859568290139 +Porphyrin and chlorophyll metabolism 2 14 2.210021969803477 0.0271036375842366 3.728155339805826 13.315533980582524 1.2215621624941897 0.2689555702886888 1.770547470360957 1.4201912411596824 1.0389071586082248 0.2908939383930566 0.0113114865314974 0.0042324529563037 0.0155240337321844 0.0834574734746242 0.0144964406909979 +Glycosaminoglycan degradation 1 6 2.17005871471893 0.0300023982551271 3.407766990291262 5.864077669902913 0.1350713234786387 0.1703873780123549 1.3379225542760151 0.7043353086258667 1.932540087143412 0.2532951180616937 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.0328731354880699 0.113339965404402 +Mtor signaling pathway 5 14 2.1632713590236525 0.0305203146096582 3.9271844660194177 12.893203883495143 -0.1175056834720911 0.5561036431268109 2.3769807958492986 2.3767180657908846 0.9104883448278088 0.3008944302982549 0.2852239797067621 0.1828652209005429 0.327507803675052 0.2616785322574622 0.0476655926672988 +Abc transporters 5 8 2.1190594496623096 0.0340854431078403 2.3762135922330097 6.366504854368932 0.6645221155900782 0.3307647417699358 1.8079428939478197 2.1798157082242287 1.1702884010083077 0.2791394174824396 0.1509425000049774 1.0 0.1758008751515455 0.01180448121602 0.0022722304352638 +Snare interactions in vesicular transport 7 10 2.1025573505229724 0.0355044814201206 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 1.0 1.0 1.0 0.5767416823779237 0.0888289826938022 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f530ee6bc02a9e671f8510398c58dd50a3cace09 --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 181, + "title": "Average number of proteins per term", + "value": 18.23204419889503 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e08a0dc0f63450f4eb129262dc00d9bef0964ed3 --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b7fc2313741b1e149070c2067372f0e95dcf1760 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,67 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosome 0.6984117547616391 3.888330541960108 0.0001009361048358 0.0181044659197083 0.014665353945674 50 P15289,Q93050,P06280,Q14108,P11279,Q13510,P16278,Q15904,P50897,P11117,P04062,P13473,P07602,Q8NCC3,Q9Y487,P10253,O15118,P17900,O14773,P10619,Q9NZJ7,O75503,P54802 23 +Glycosaminoglycan biosynthesis keratan sulfate 0.9285297549591598 3.5952371421751956 0.0003240962197939 0.0569829574407483 0.014665353945674 2 O60512 1 +Glycosphingolipid biosynthesis lacto and neolacto series 0.9285297549591598 3.5952371421751956 0.0003240962197939 0.0569829574407483 0.014665353945674 2 O60512 1 +Glycosaminoglycan biosynthesis heparan sulfate 0.909610112648759 3.2851717203602004 0.0010192023403348 0.1685380121265404 0.0273200821627229 3 Q7LGA3 1 +Primary immunodeficiency 0.9073552138418486 3.275011222207197 0.0010565777631992 0.1741496338297925 0.0273200821627229 3 Q03518 1 +Glycosaminoglycan biosynthesis chondroitin sulfate 0.8398483080513318 3.181240007978979 0.0014664608410652 0.2332728086663307 0.0294921569147572 2 Q96L58 1 +Renin angiotensin system 0.8705264767146472 2.899415511400889 0.0037385908756566 0.4923449178404568 0.0565582956857522 4 P10619 1 +Nicotinate and nicotinamide metabolism 0.8888929054530988 2.831752403386201 0.0046293680377074 0.5682295213596974 0.0565582956857522 5 Q13423,P43490 2 +Parkinsons disease 0.5468327801726567 2.789047505176507 0.0052863310276958 0.6168634836260207 0.0565582956857522 55 P47985,P12236,P14406,P03886,P22695,P45880,P13073,O14949,P21796,P00403,P24539,O43676,P12235,Q9UDW1,P21912 15 +Alpha linolenic acid metabolism 0.798657718120793 2.7691666943075166 0.0056199873539239 0.6394363729269591 0.0565582956857522 3 Q15067,O95864 2 +Calcium signaling pathway 0.722691986200167 2.719598888321769 0.0065361148231086 0.6948402731564832 0.0565582956857522 19 P16615,Q9Y277,P45880,P21796,P20020,P12236,P12235 7 +O glycan biosynthesis 0.8295547398908258 2.7125376828836707 0.00667701891894 0.7025750034859359 0.0565582956857522 4 Q8N4A0,O43505 2 +Sphingolipid metabolism 0.8245972856819339 2.7028638931498765 0.0068744889783787 0.7130878222453578 0.0565582956857522 12 Q13510,P15289,O95470,P04062,P16278,P06280,Q06136,O43681 8 +Cardiac muscle contraction 0.6844402282586922 2.6134710558876977 0.0089627675032877 0.803987064663826 0.0705330833954382 21 P14406,P22695,P13073,O14949,P00403,Q9UDW1,P47985 7 +Oxidative phosphorylation 0.4998659475267885 2.446611848884541 0.0144206045919825 0.9278589581724934 0.1003895935057248 61 O75964,Q7KZN9,Q93050,P14406,P03886,P22695,Q9UDW1,P13073,O14949,P00403,P24539,O43676,Q86Y39,Q9Y487,P47985 15 +Steroid biosynthesis 0.7431212594488719 2.387676481718566 0.0169552599323516 0.9547348083623663 0.109603644562702 13 Q15392,O76062,Q15800,Q9UBM7,Q16850,Q14534,P48449,P37268 8 +Riboflavin metabolism 0.8090526711511365 2.3328808526788607 0.019654399582786 0.9724807906315212 0.1185815441494757 6 Q9NPH0 1 +Graft versus host disease 0.736457135674097 2.2713698665085036 0.0231245969943962 0.9855159308404492 0.1195872015995922 4 P49327,P01889 2 +Autoimmune thyroid disease 0.736457135674097 2.2713698665085036 0.0231245969943962 0.9855159308404492 0.1195872015995922 4 P49327,P01889 2 +Allograft rejection 0.736457135674097 2.2713698665085036 0.0231245969943962 0.9855159308404492 0.1195872015995922 4 P49327,P01889 2 +Porphyrin and chlorophyll metabolism 0.6921530327303704 2.210021969803477 0.0271036375842366 0.9930808792790304 0.1362710667429674 14 P30519,P09601 2 +Glycosaminoglycan degradation 0.773409552974643 2.17005871471893 0.0300023982551271 0.9959682875380128 0.1406491626228852 6 P16278 1 +Mtor signaling pathway 0.6835674909044475 2.1632713590236525 0.0305203146096582 0.996339780779924 0.1406491626228852 14 P54646,P42345,Q15382,P51812,Q15418 5 +Steroid hormone biosynthesis 0.6713565972922362 2.1337342220761224 0.0328645430358272 0.9976384218798952 0.1428069141564852 3 Q53GQ0 1 +Abc transporters 0.7476877045950605 2.1190594496623096 0.0340854431078403 0.9981210867687772 0.1428069141564852 8 O14678,Q03519,Q9NUT2,Q03518,P08183 5 +Snare interactions in vesicular transport 0.7285548072262591 2.1025573505229724 0.0355044814201206 0.998560078722658 0.1428069141564852 10 O95249,O15400,Q13277,O15498,Q9P2W9,Q13190,Q86Y82 7 +Metabolism of xenobiotics by cytochrome p450 0.6857862641824924 1.88818545566384 0.0590010576770527 0.999983418130754 0.2061361535779925 10 P07099,P78417 2 +Huntingtons disease 0.4232299911037284 1.873377974367132 0.0610162093089323 0.9999887509656 0.2083761110361652 81 P42858,P14406,P14854,P45880,P21796,O43676,P42574,P21912,Q9Y277,P13073,P24539,P12235,P47985,O14949,Q9Y6M9,P00403,P12236,Q9UDW1,Q9UJW0,P22695,P51970,Q07812,P05141 23 +Alzheimers disease 0.4383527127521271 1.8570344001092467 0.0633062600730782 0.9999927694918777 0.2105077914312859 62 P14406,P14854,O43676,P42574,P21912,P0DP25,P13073,P24539,P47985,P14735,O14949,Q9Y6M9,P00403,Q9UDW1,P05067,P49327,P22695,P51970,P16615 19 +Other glycan degradation 0.6881144081948009 1.8296178311953912 0.0673071054920768 0.9999966680463922 0.2137295805976475 8 P04062,P16278 2 +Vibrio cholerae infection 0.486667812666214 1.4506364458466718 0.1468811210896587 0.9999999999996744 0.3909629840768859 24 O43731,P24390,Q9Y487 3 +Base excision repair 0.5292735967561732 1.400037724428136 0.1615020219998195 0.9999999999999858 0.4175980854566762 16 P28340,P09429,Q9UGN5,Q07864 4 +P53 signaling pathway 0.5208483107016411 1.3482005306622824 0.1775938939935666 0.9999999999999996 0.440335545381309 16 P49327,O95067,Q13535,P06493,Q13315,P14635,Q07812,P42574 8 +Galactose metabolism 0.5329882192404052 1.3071422508921138 0.1911644041437858 1.0 0.4522874084698386 14 P52789,P16278,P10253 3 +Protein export 0.5125897820899805 1.2592343774713413 0.2079456879298939 1.0 0.4590020672598879 15 P67812,Q15070 2 +Drug metabolism cytochrome p450 0.5498714536300748 1.1543086512944292 0.2483736509142939 1.0 0.5078528080934306 9 O15217,P78417 2 +Pantothenate and coa biosynthesis 0.5148861646234729 1.1349193004202751 0.2564091323906874 1.0 0.5156672551412713 4 O15382,Q9NVE7,Q13057 3 +N glycan biosynthesis 0.471958446513824 1.0816469900693455 0.2794094162011649 1.0 0.5437968207786112 17 Q16706,P46977,O60512,Q9BT22,Q86YN1,Q2TAA5 6 +One carbon pool by folate 0.5235437876562292 1.0658676443883697 0.2864834770706341 1.0 0.5516330781891998 11 P00374 1 +Biosynthesis of unsaturated fatty acids 0.4919234582803811 0.8533658187486106 0.3934564705717056 1.0 0.6914137978007643 9 Q15067,Q53GQ0,O95864,O00767,Q9NZ01 5 +Retinol metabolism 0.4686197237799419 0.7886784233997595 0.4302999818698589 1.0 0.7235908834819588 5 Q6NUM9,O94788 2 +Regulation of autophagy 0.4794643004575787 0.7726131399869113 0.4397513656520191 1.0 0.7235908834819588 8 P54646 1 +Vasopressin regulated water reabsorption 0.4206075216060754 0.7297994634073376 0.4655127725325463 1.0 0.7326766245947033 16 P61020,Q15907,Q13409 3 +Progesterone mediated oocyte maturation 0.3635951733972219 0.6923483372080111 0.4887186013939264 1.0 0.7473591181476261 29 Q9H1A4,O95067,P14635,P06493,P51812,Q15418 6 +Ether lipid metabolism 0.4669880279085161 0.6845271555052187 0.4936423477600997 1.0 0.7473591181476261 6 Q8NF37,O00116 2 +Ribosome 0.3203056058091154 0.6767346519026352 0.498574326480846 1.0 0.7473591181476261 71 P46781,P46778,P62753,P26373,P62910,P46779,P46776,P84098,P62841,Q9Y3U8,Q07020,P83731,P27635,P42766,P62917,P61353,P62266,P47914,P62424,P61513,P62701,P61927,P83881,P62277,P36578,Q02878,P62847,P39023,P62269,P62750 30 +Amyotrophic lateral sclerosis als 0.4401657596512709 0.6072180174848222 0.5437062366500549 1.0 0.7552088467514054 10 Q07812,Q9BUN8 2 +Neurotrophin signaling pathway 0.3367768229832033 0.5948962235139055 0.5519128418126513 1.0 0.7567895785461355 38 P0DP25,P51812,Q9Y5V3,Q15418 4 +Basal transcription factors 0.4401454905202982 0.5800301715526005 0.5618942714903357 1.0 0.7589765905951549 8 P35269 1 +Long term potentiation 0.3723323679095116 0.5163005960982726 0.6056444799673231 1.0 0.7789527273822547 19 P51812,Q15418 2 +Glycosylphosphatidylinositol gpi anchor biosynthesis 0.4037884437110514 0.4777975400336396 0.6327943121999973 1.0 0.8009494441132833 5 Q92643,O43292 2 +Glutathione metabolism 0.3498327820161703 0.4534801698367621 0.6502030194381399 1.0 0.804306461248277 23 O95881,O15217,P78417 3 +Antigen processing and presentation 0.36008737972256 0.4181596706958245 0.6758303798432843 1.0 0.8155019916775631 18 Q03519,Q03518 2 +Glycerophospholipid metabolism 0.3424969624013033 0.301190631266291 0.7632691334988939 1.0 0.8855879048929474 17 P52429,O15228,Q8NCC3,P48651,Q96N66 5 +Viral myocarditis 0.3604447045055569 0.2706475820463941 0.7866620959239852 1.0 0.9069161742817918 12 P63000,P35579,P01889,P10321,O43432,Q7Z406,P78310,P78344,P04439,P35580,P42574 11 +Proteasome 0.2951815852108831 0.2397641765339083 0.8105130799637366 1.0 0.92265954385809 37 P20618,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 9 +Mismatch repair 0.3261625691178467 0.2313384209431275 0.8170519004985233 1.0 0.9242899624389544 18 Q9UQ84 1 +Glycerolipid metabolism 0.3323831023506171 0.1971266725110557 0.8437284112864805 1.0 0.9485393940549874 14 P52429,P06280,P51648,Q6UWP7,P30837 5 +Type ii diabetes mellitus 0.3380983448787381 0.1602436407553521 0.8726891531895964 1.0 0.963150833703152 11 P52789 1 +Peroxisome 0.2833893430034696 0.1379793315230561 0.890256752346783 1.0 0.9727477696479664 35 Q15067,O14678,Q9NR77,O15228,O75381,A8MXV4,O00116,Q8WVX9,O43808,O15254 10 +Starch and sucrose metabolism 0.3124817565217988 0.1356053022346152 0.8921333135997924 1.0 0.9727477696479664 15 P06737,P52789,P06744,P35573,Q04446,P10253 6 +Phosphatidylinositol signaling system 0.3080739344263959 0.1239918908273438 0.9013216956983194 1.0 0.9768815983317116 16 P0DP25,P52429,Q8TBX8 3 +Hypertrophic cardiomyopathy hcm 0.3167729251851486 0.0868073696888133 0.9308246295758082 1.0 0.9894921233284624 11 P54646,P50402,P54619,P16615 4 +Epithelial cell signaling in helicobacter pylori infection 0.2868862136013544 0.0817769948786079 0.9348240502163928 1.0 0.9894921233284624 23 Q9Y487 1 +Tyrosine metabolism 0.3032617509595579 0.0474379928899739 0.9621641491437468 1.0 1.0 10 O43708 1 +Nucleotide excision repair 0.275057582383031 0.0372097808523733 0.9703177400218916 1.0 1.0 25 P28340,P41208 2 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e9fb2d5597b37368683faa66bf5bf1d57827293e --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Taurine and hypotaurine metabolism", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN2", "ACTN4", "ACY1", "ADAR", "ADH5", "ADI1", "ADK", "ADO", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALYREF", "AMPD2", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEX1", "APIP", "APP", "APRT", "AQR", "ARAP1", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARG2", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG4B", "ATG7", "ATIC", "ATM", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATR", "AURKA", "B3GALT6", "B4GALT3", "B4GAT1", "BAIAP2", "BAX", "BCAS2", "BCAT1", "BCAT2", "BCKDHB", "BCR", "BDH2", "BECN1", "BIRC6", "BLM", "BLVRA", "BPNT1", "BRCA1", "BRD8", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CBL", "CBR1", "CCDC6", "CCNB1", "CCNB2", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC40", "CDC42", "CDC5L", "CDC6", "CDH2", "CDK1", "CDK2", "CDK4", "CDK5", "CETN2", "CFL1", "CFL2", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHMP5", "CHORDC1", "CHUK", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT10", "CNOT3", "CNOT4", "CNOT7", "COASY", "COMT", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT1A", "CPT2", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CXADR", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DARS", "DARS2", "DAXX", "DBT", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERA", "DERL1", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOLPP1", "DPM1", "DPYSL2", "DPYSL5", "DSC2", "DSE", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "EMD", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "ERBIN", "ERCC2", "ERCC3", "ERO1A", "ESPL1", "EXO1", "EXOC3", "EXOC4", "EXOC7", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EZR", "FABP5", "FADS2", "FAH", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLCN", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GBE1", "GCAT", "GCDH", "GCLC", "GCLM", "GFPT1", "GGA1", "GGA2", "GGCT", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNE", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GPT2", "GRB2", "GRHPR", "GSK3A", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTSE1", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HCCS", "HDAC1", "HDAC2", "HERC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIP1", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGF2BP1", "IGF2R", "IKBKB", "ILK", "IMPDH2", "INPP4A", "INPPL1", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRS4", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITPA", "ITPK1", "IVD", "JUP", "KARS", "KDELR1", "KDELR3", "KDSR", "KIDINS220", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LIG1", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LPCAT4", "LRP1", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LYPLA1", "LYPLA2", "M6PR", "MAGED1", "MAN1A2", "MAN2A1", "MAN2B1", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MARCKS", "MARCKSL1", "MARS", "MARS2", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MGST2", "MGST3", "MID1", "MIF", "MINPP1", "MMAB", "MOGS", "MPDZ", "MPHOSPH6", "MPI", "MPST", "MRE11", "MRPL13", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTMR2", "MTMR6", "MTOR", "MTR", "MUT", "MVD", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCAM1", "NCBP1", "NCBP2", "NCKAP1", "NCL", "NCSTN", "ND1", "NDUFA10", "NDUFA11", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4", 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0.1757583754913391 4.192861933829232 2.1968580551223003 2.1941615995620167 0.2567064655985949 1.035486132387102e-05 0.2633971592089756 1.949284152634766e-06 2.30996546554735e-08 2.7266368609321845e-08 +Protein localization 26 77 3.155630087042733 0.0016015183134483 25.97087378640777 74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 2.042695571996302e-07 6.300443265267913e-05 9.849004725073229e-07 5.32231515886556e-08 3.180588104226038e-11 +Heparan sulfate heparin hs gag metabolism 3 5 3.0190816409624603 0.0025354219756776 2.4320388349514563 4.83252427184466 0.8003221575390526 0.2230961855611341 1.2648123228701085 1.2708877857521428 1.4628061886044337 0.2633127679646707 0.230458544012733 0.1457663642848915 0.266209970857853 0.0070923684446229 0.0682397501835214 +Transport of small molecules 53 154 2.914781693882735 0.0035593742557713 41.730582524271846 151.96601941747574 1.4265613612661356 0.380396759556163 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1.2175929202976112 2.2116324239586063 0.2290247571497847 0.0023797484711094 0.1499686155438198 0.0038117145357013 1.1213911854546629e-05 2.321126472472232e-06 +Sphingolipid de novo biosynthesis 4 10 2.6379893524778124 0.0083399200402529 4.08252427184466 10.614077669902912 1.3205451179619188 0.2079933246203462 1.939118365602947 1.3614298144224892 1.289169434780902 0.261809046515659 0.0016315078589778 1.0 0.0001585002786519 0.0005910649168726 0.002368909886278 +Mitochondrial calcium ion transport 7 15 2.572550449982171 0.0100952241441689 6.502427184466019 16.12135922330097 1.0650233237312683 0.2089377868120644 3.410790121717641 1.246287729205551 1.626144580445205 0.28031724173526 0.0124366578275625 0.0046633751497463 0.0170518298819148 0.0135296171343662 4.010191317578068e-05 +Mitophagy 2 12 2.529756808806917 0.0114141609768627 3.662621359223301 11.783980582524272 1.3564301304992197 0.1917930287367771 1.8155907654273165 1.3363606860118669 1.2723890100166135 0.2636913304405313 0.0009305834118446 0.0002088865488349 0.0015052123544451 0.0195244436529747 0.0272826327042602 +Ras processing 2 5 2.5019639437764503 0.0123506502459656 1.3519417475728157 4.871359223300971 1.1011688928930974 0.2799307194914149 1.0191949595335985 0.8620674500492106 1.0561018280407846 0.2880746444526379 1.0 1.0 1.0 0.0762921742488627 0.0624183143373935 +Autophagy 12 53 2.4833808102984327 0.0130141878426779 10.618932038834952 49.09466019417476 0.5991637048381673 0.5478738847433878 5.048592116085888 6.4120843612202885 0.9575127000026346 0.3634200031879806 0.0893853301358435 0.0256886126869327 0.1295090696181635 0.3867509927062335 0.0107221044968784 +Metabolism of steroids 14 50 2.4687579083532727 0.0135582909854508 11.16019417475728 45.26699029126213 0.7621248609364072 0.3994790342082778 4.702670999060317 5.049423467032678 1.2014135082145578 0.3371477938402821 0.0098095354399013 0.0139189683537814 0.0172011735219368 3.769325873542945e-05 4.512915836952935e-07 +Pink1 prkn mediated mitophagy 2 8 2.4685774228056645 0.0135651303808694 3.2815533980582523 8.473300970873787 1.395617281862234 0.1554977461962819 1.6230588150315317 0.9738153254376878 1.3577427922485954 0.2414588001366878 0.000325764016582 7.189730386960826e-05 0.0005309775927247 0.0074273483269255 0.0079931710216612 +Copi mediated anterograde transport 11 57 2.4049504086066387 0.016174660545033 14.364077669902912 53.29368932038835 0.4832864212749729 0.5898511157237575 6.303679837135847 4.572358803691129 1.0202251873333663 0.3614704266753352 0.1635242481649697 0.3555919235953944 0.2107495506364678 0.0646269414847783 0.0038532557542741 +Slc mediated transmembrane transport 12 20 2.3882018763533326 0.016931038651869 8.672330097087379 21.910194174757283 1.4735742044813558 0.239038892478899 4.348519601656105 3.146764860695784 1.3934177975338422 0.3068823132077037 0.1985982792971584 0.3928429005031874 0.0731929968318565 0.035804698333377 0.0250984668710431 +Caspase activation via extrinsic apoptotic signalling pathway 3 5 2.374344572115438 0.0175801359888423 1.4320388349514563 3.412621359223301 -0.0581954782096571 0.5236809101108786 1.0940007270220875 1.3616223626883153 1.0370116916215335 0.3144517115099657 1.0 1.0 1.0 0.357118555081159 0.2179847922025966 +Peptide ligand binding receptors 3 7 2.3722210975563747 0.0176815065555295 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.1298272630870375 1.0 0.1515272625734178 0.00062382482254 0.0079931710216612 +Class a 1 rhodopsin like receptors 3 7 2.3722210975563747 0.0176815065555295 2.8640776699029127 6.796116504854369 1.193322814833652 0.1851946070449122 1.2850789986620814 0.7987760455175396 1.3206182868906609 0.2426624676455473 0.157867792113085 1.0 0.1837383274168749 0.001453665706999 0.0172333771485565 +Selective autophagy 8 35 2.355408207644282 0.018502367688268 7.315533980582524 31.50728155339806 0.9304065525388932 0.4028226131520862 3.350474746292583 3.101431769008479 1.074438805028982 0.3502038092942861 0.0171479808364698 0.0042640190855243 0.0264876267470493 0.2210522410556178 0.0049679147591338 +O linked glycosylation 3 5 2.323833707240288 0.0201344084033501 1.766990291262136 4.330097087378641 0.8603336668848929 0.3169450005244383 1.1529100664253755 1.1773621125091884 1.0771631098821022 0.279831511700265 1.0 1.0 1.0 0.2076979954646016 0.2421884168027767 +Wax and plasmalogen biosynthesis 3 5 2.2811363915975007 0.022540377287894 2.0072815533980584 4.014563106796117 0.4941193635445591 0.4650109497457026 1.185447925809208 0.5868970183049173 0.9576481321233842 0.3128017902780047 1.0 1.0 1.0 0.1154193350298319 0.0214944247869924 +Metabolism of steroid hormones 2 6 2.277273084795528 0.0227699231666271 2.0606796116504853 5.754854368932039 0.472180937604631 0.3480370596589613 1.2262134961449431 0.9324780265795692 1.1891708581028433 0.2889255498989442 0.0040983965897468 0.0015075035399645 0.0056684159955205 0.00262770885776 0.0182159139614431 +Biological oxidations 7 48 2.262406360848069 0.0236723082974121 9.58980582524272 42.907766990291265 0.5797258374932459 0.4965502516733612 4.863095917627343 3.5143586004975274 1.0031637620757048 0.3373734498260092 0.0071480005919465 0.010878638830109 0.0126614085231583 0.0019595403906339 0.0058601021721165 +Transport to the golgi and subsequent modification 26 82 2.249124758937437 0.0245045597387507 20.604368932038835 77.1626213592233 0.4958457957496105 0.6299790557050085 8.044251420264837 7.0373663516482345 0.9638132242129624 0.3700222187340509 0.3399211419271696 0.5194717620066895 0.4176554250980517 0.0682104000582474 0.0056545230935283 +Synaptic adhesion like molecules 0 5 2.248289723342324 0.0245577215864125 1.6674757281553398 5.951456310679611 1.045730316736721 0.2890276876766184 1.4188777313077996 1.1438195320406324 0.8614150619700692 0.2468687149363868 0.0860283086388496 0.0526645480715484 0.1008375048293403 0.2365379696877526 0.4230365159515766 +Metabolism of porphyrins 2 9 2.228661786138729 0.0258364166725999 2.766990291262136 9.186893203883496 1.2638611374915407 0.2204767139400954 1.3861582272503026 1.170645435718008 1.0950295956895657 0.2541910601955712 0.0082254277129148 0.0030581061915538 0.0113213926532688 0.062605312422627 0.0079931710216612 +Gastrin creb signalling pathway via pkc and mapk 1 6 2.205275953792793 0.0274347361537619 2.1019417475728157 5.223300970873787 -0.3886444460554432 0.4412055381641779 1.2064938033730337 0.9236066791475944 1.088184116363022 0.3134692687748335 0.1081933924999157 0.066549445548378 0.1265462710440741 0.0439142352380576 0.1467539296032722 +Iron uptake and transport 3 18 2.191758647857355 0.0283969384691775 4.089805825242719 17.9126213592233 1.0360420001787272 0.323786301352462 2.0477771422769826 0.9863810102632052 1.0014322629164618 0.2971986354372174 0.0380950107843236 0.0148056693212618 0.005693097574516 0.0130060888805635 0.0359117122080593 +Class i peroxisomal membrane protein import 4 8 2.1848280107939653 0.0289014594360388 4.300970873786408 9.604368932038836 1.1426576411245968 0.2560233101944223 2.515331441636984 1.9424437465598188 1.2133199793435778 0.2911424942178205 0.1439609493286736 1.0 0.1677870330809631 0.3727200206787977 0.0120515986398723 +Ire1alpha activates chaperones 5 26 2.1694427009555417 0.0300490900731014 6.050970873786408 24.223300970873787 0.9379365742980283 0.4047880585679882 2.6930013625985207 2.1985522104416564 1.0262193137091864 0.3353529084578252 0.0496923416317891 0.1948770046367652 0.0666692325567911 0.0040251974639471 0.0050026695308212 +Sialic acid metabolism 1 6 2.161791789009611 0.0306342286773404 1.633495145631068 4.638349514563107 0.3331729503932819 0.3039098658637086 1.1012545438565893 0.8492059078669172 1.3430882059420008 0.2726683810004117 0.1226742139485862 0.0756950383436983 0.1432798584585485 0.0561137872346343 0.1818418904091173 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 6 11 2.109450871526052 0.0349056823762539 4.016990291262136 10.99757281553398 1.1239772251284714 0.2752182956921286 1.9514004604865949 1.181365809872934 1.0815649178051203 0.2865915409883788 0.0102339970863349 0.0892490045576324 0.014058804472369 0.0009779431698101 1.8924379158190217e-05 +Er to golgi anterograde transport 23 78 2.106640572268576 0.0351487470735241 19.152912621359224 74.15776699029126 0.4357486981835305 0.6456866134420882 7.637631429097237 6.107600140782552 0.9360192475456132 0.3613336360589621 0.2828385727136282 0.4717478376334574 0.3526837640973719 0.0932188412403147 0.0040293935237904 +Heme signaling 0 7 2.0842140505375597 0.0371407012568452 1.230582524271845 5.803398058252427 0.6243516489333526 0.4389875136545328 1.4355867683297088 1.6714879444213002 0.8385522152075133 0.2749710688420202 0.2552924739487913 0.1624541869963563 0.2941077913158182 0.5870305126491255 0.8350628750672632 +Keratan sulfate keratin metabolism 2 6 2.062897862952904 0.0391223332158596 3.1359223300970873 5.439320388349515 0.1148000450757159 0.1857420338858874 1.294488268568909 0.7592200419566036 1.8452752770630356 0.2520366769461069 0.1298272630870375 0.0802348466038066 0.1515272625734178 0.0074273483269255 0.0470360579614364 +Aurka activation by tpx2 12 39 2.0443921494165727 0.0409148222487665 10.276699029126211 31.893203883495147 0.5790832053921023 0.5039527741558584 4.914920890107843 4.281168113347361 0.9784215516709706 0.3534896123548716 0.4505349580539141 1.0 0.5071521873221705 0.1005919349614823 0.0027070136406106 +Cytosolic sulfonation of small molecules 1 5 2.0398380199729544 0.0413664616370073 1.4174757281553398 4.563106796116505 0.2618118421521333 0.5085407170975286 1.1618889194158637 0.9771158561611718 0.947384439548352 0.2939581688170716 0.1081933924999157 0.066549445548378 0.1265462710440741 0.0439142352380576 0.1467539296032722 +Cholesterol biosynthesis 9 18 2.0360444113141893 0.0417458958904892 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 0.1783105780413945 0.1114073342812727 0.2070995190727305 1.774557205833731e-05 7.319750106126091e-08 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 22 63 2.0357579342238283 0.0417746684009834 20.8373786407767 62.38106796116505 0.8350130317954786 0.3584533980641267 8.974357262450994 5.887120286458052 1.9056004199022172 0.3784220720284639 0.0685404232852726 0.1106003446312499 0.0051243305729325 2.3111698587352784e-05 2.951498304174892e-06 +Intra golgi and retrograde golgi to er traffic 30 95 1.9666103528017973 0.0492281490153092 23.762135922330096 91.83252427184466 0.7836914286379623 0.5449079285432085 8.961715947260837 10.213669235838784 1.1120768516172963 0.4008074869702365 0.182766124350531 0.2224854546727621 0.2522992371519743 0.1502057024283079 0.0153800713476268 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..72b5f89b894e9ea6f023eb1710a7c0d0ab09e845 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 1411, + "title": "Average number of proteins per term", + "value": 20.250177179305457 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..113df0f0147838ddcecc6f8e90b99a998302041f --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a37c200410e57f07bd310ab68999c7e6b3cbbf8c --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,373 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Metabolism of lipids 0.4710898778464791 3.757750696887952 0.000171447566384 0.2148914230628082 0.0073400203702529 200 Q6IAN0,P54646,Q15392,Q8N2A8,P15289,Q15165,P30536,Q8NAN2,Q14534,Q16850,P38435,Q8IV08,P06280,O95864,O43772,O75448,Q13510,O76062,P16278,Q9NPH0,Q9Y6B6,Q14849,Q9H7Z7,O15228,A8MXV4,Q06520,Q9UBM7,P50897,P48449,P48651,Q14739,O43681,Q96G23,Q96N66,P23786,O95470,Q9BXW6,P04062,O15269,Q53GQ0,P07602,O00116,P51648,Q8NCC3,Q9BTU6,Q06136,O75845,Q15067,P49327,Q16836,Q15800,P17900,P49748,Q9NUQ2,Q8TBX8,P10619,P27544,Q9NZJ7,O00767,O43808,P37268 61 +Creb phosphorylation 0.9364060676779402 3.6309845452341096 0.0002823420932578 0.328634072767991 0.0088328791468983 2 P51812 1 +Keratan sulfate biosynthesis 0.9285297549591598 3.5952371421751956 0.0003240962197939 0.3670563533986142 0.0091459953225839 2 O60512 1 +Heme degradation 0.9783015261033204 3.5886348356016926 0.0003324140592313 0.3744438669256434 0.0091967889720672 3 P30519 1 +Sphingolipid metabolism 0.7960241551465616 3.5780949903728376 0.0003461076725135 0.3864186707695234 0.0093008892468096 26 Q13510,P15289,O95470,P04062,P16278,P17900,P07602,P06280,P51648,P27544,P10619,Q9NZJ7,Q06136,O43681,Q96G23 15 +Synthesis of pg 0.92094515752625 3.560661514009175 0.0003699216888515 0.4067005714293039 0.0093008892468096 2 Q8N2A8 1 +Hs gag degradation 0.963206735853328 3.522932967709845 0.00042679929132 0.4524723678265291 0.0098723573779115 3 P16278 1 +Abacavir transport and metabolism 0.8722287047841312 3.3349203367973224 0.0008532383892634 0.7001381093139761 0.0143843919232736 2 P49902 1 +The activation of arylsulfatases 0.87193698949825 3.3335490580639644 0.0008574554901437 0.7019186067327836 0.0143843919232736 2 P15289 1 +Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.8547257876312712 3.2522204838114535 0.0011450715913847 0.8014316222770024 0.0170073264783569 2 P49327 1 +Proton coupled monocarboxylate transport 0.8497666277712974 3.228630966328967 0.0012438429020862 0.8272923074054882 0.0179087993351395 2 P35613 1 +Caspase activation via dependence receptors in the absence of ligand 0.8421820303383778 3.192416371187302 0.0014108779330657 0.8635987593061292 0.0193276578985992 2 Q9Y5V3 1 +Protein localization 0.5489760883965858 3.155630087042733 0.0016015183134483 0.8958115274545109 0.0197790262587736 77 Q9NS69,P09601,P21796,Q8N4H5,O60830,Q9Y512,Q9Y5J9,Q9NR77,O15228,Q13190,A8MXV4,Q99595,P12235,Q9Y584,P14735,Q13505,Q9Y5L4,O00116,P51648,P12236,Q8TB36,P05067,Q15067,Q15388,P46379,O14925 26 +Downregulation of erbb4 signaling 0.8191365227537931 3.0813523800849194 0.0020606262499258 0.945553866417307 0.0244331398205495 2 P46934 1 +Activation of ppargc1a pgc 1alpha by phosphorylation 0.8144690781796843 3.05866753333662 0.0022232372996349 0.9567379789589944 0.0259255192544204 2 P54646 1 +Heparan sulfate heparin hs gag metabolism 0.931968606678004 3.0190816409624603 0.0025354219756776 0.9721806456058348 0.028169137068356 5 P54802,P16278,Q7LGA3 3 +Transport of bile salts and organic acids metal ions and amine compounds 0.8500145900204217 3.0121715553060966 0.0025938596139798 0.974387911180739 0.0283715962428337 3 P35613,Q15043 2 +Vitamin d calciferol metabolism 0.842285567293537 2.976069320905438 0.0029196885675546 0.9838479191566994 0.0312097012789364 3 P04062 1 +Noncanonical activation of notch3 0.7952158693115507 2.9644006615897505 0.0030327314128149 0.9862358236745996 0.0317030208742236 2 P67809 1 +Mucopolysaccharidoses 0.8849870668382571 2.9643486220674684 0.0030332443784693 0.9862458127916484 0.0317030208742236 4 P16278 1 +Transport of small molecules 0.4400006246179991 2.914781693882735 0.0035593742557713 0.9934692691682744 0.0354327247038187 154 P35613,P30519,Q13546,P53985,Q9NUT2,Q93050,Q9HD20,P55011,P51665,P45880,P09601,P21796,P61289,Q9BU23,P20020,O95202,Q99436,Q15043,Q9Y277,Q8NE86,Q8TB61,P60900,Q9Y6B6,Q15904,Q9C0H2,Q9UBX3,P49721,P08183,P12235,Q8WTV0,P28072,P63218,Q4KMQ2,P51798,P28074,Q92530,Q9BUN8,P12236,Q9Y6M7,Q9Y487,P30825,Q99623,P20618,Q70HW3,O15118,P11166,Q9UJZ1,Q9Y5K8,Q99797,P05141,O75027,P16615,Q8IYU8 53 +Glycosaminoglycan metabolism 0.7939808074722934 2.8530391701665256 0.0043303283574847 0.9978089206083636 0.0404641941219266 15 P16278,O60512,Q8TB61,Q96L58,Q7LGA3,P54802 6 +Mitochondrial protein import 0.6171627448583461 2.83854452092686 0.0045319796668084 0.9983535887996984 0.041994578624156 36 Q9NS69,O14925,Q13505,Q9Y5L4,P21796,Q99595,Q9Y584,P12235,Q8N4H5,O60830 10 +Rsk activation 0.8567415815374466 2.837023291045387 0.0045536290074386 0.9984033442812082 0.041994578624156 4 P51812 1 +Glycosphingolipid metabolism 0.7759480554531675 2.8185423316210807 0.0048242249322889 0.9989120429229092 0.0436344960221776 16 Q13510,P15289,P04062,P16278,P17900,P07602,P06280,P10619,Q9NZJ7 9 +Pregnenolone biosynthesis 0.8412811636370043 2.766467113217223 0.0056667300192396 0.999670685357522 0.0495497101766639 4 P30536 1 +Vitamin c ascorbate metabolism 0.787478110109551 2.715278597028045 0.0066220037626121 0.999915158131158 0.0530498894144705 3 P78417 1 +O linked glycosylation of mucins 0.8295547398908258 2.7125376828836707 0.00667701891894 0.9999215357475034 0.0530498894144705 4 Q8N4A0,O43505 2 +Pre notch processing in golgi 0.8293901947248326 2.7117783859397018 0.0066923319034555 0.9999232240751516 0.0530498894144705 4 Q15363 1 +Sphingolipid de novo biosynthesis 0.839937777484717 2.6379893524778124 0.0083399200402529 0.999992621736604 0.0630658824275132 10 O95470,Q96G23,Q06136,P51648 4 +Release of apoptotic factors from the mitochondria 0.7266627771295047 2.619412445486248 0.0088081380157629 0.9999962107456606 0.0644344474724632 2 Q07812 1 +Mitochondrial calcium ion transport 0.7408933407646292 2.572550449982171 0.0100952241441689 0.9999993942199488 0.070185368666513 15 Q9Y277,Q8NE86,Q8IYU8,P45880,P21796,Q99623,O95202 7 +Mitophagy 0.7891747094474573 2.529756808806917 0.0114141609768627 0.999999907679656 0.0745619497145989 12 Q9NS69,P21796 2 +Ras processing 0.8154364595710502 2.5019639437764503 0.0123506502459656 0.9999999757603916 0.0788541515703957 5 P49356,O60725 2 +Ngf stimulated transcription 0.7417310868056197 2.490970218237978 0.0127394797820039 0.9999999860931796 0.0806570680913108 3 P50570 1 +Autophagy 0.5152163567396613 2.4833808102984327 0.0130141878426779 0.9999999906093928 0.0816134179823047 53 P54646,Q15382,Q9NS69,P42345,P13473,Q15388,O95613,Q13315,Q7Z3C6,Q9UBN7,P21796,Q8N4H5 12 +E2f enabled inhibition of pre replication complex formation 0.7796263864564912 2.4788451657096933 0.0131808509954409 0.9999999926003896 0.0816248341374492 4 Q9Y619,P14635,P06493 3 +Nade modulates death signalling 0.6992415402567057 2.47718904482396 0.0132421741918129 0.9999999932215948 0.0816248341374492 2 P42574 1 +Metabolism of steroids 0.522716468969273 2.4687579083532727 0.0135582909854508 0.9999999956869609 0.08198313936404 50 Q15392,O76062,P04062,Q15800,Q9Y6B6,Q53GQ0,Q14849,P30536,Q14534,Q16850,P38435,P48449,Q14739,P37268 14 +Pink1 prkn mediated mitophagy 0.8221855776092332 2.4685774228056645 0.0135651303808694 0.9999999957289496 0.08198313936404 8 Q9NS69,P21796 2 +Ra biosynthesis pathway 0.7338780274292328 2.451842312470113 0.0142126930122541 0.9999999983090684 0.0853366376182578 3 O94788,Q8NBN7 2 +Activated notch1 transmits signal to the nucleus 0.7335291599198737 2.4500998072123994 0.0142816621325665 0.999999998468025 0.0853873952078448 3 Q96J02 1 +Cytochrome p450 arranged by substrate type 0.7327435561501676 2.44617458251197 0.0144381068755463 0.9999999987754196 0.0858055296345509 3 Q16850 1 +Copi mediated anterograde transport 0.5014304248657195 2.4049504086066387 0.016174660545033 0.999999999898304 0.0943076282191801 57 O95249,Q9Y3B3,P24390,Q9BVK6,O43731,Q13190,Q13409,Q15363,P18085,P49755,O75935 11 +Endosomal vacuolar pathway 0.7615731452018328 2.3926962260818248 0.016725082034215 0.9999999999538288 0.0971155997953805 4 P01889,Q9UIQ6 2 +Slc mediated transmembrane transport 0.6549926080457015 2.3882018763533326 0.016931038651869 0.999999999965644 0.0979085882696199 20 P35613,Q70HW3,P53985,Q8TB61,P55011,Q9UBX3,P05141,P12236,P12235,Q9Y6M7,P30825,Q15043 12 +Caspase activation via extrinsic apoptotic signalling pathway 0.7877878668637641 2.374344572115438 0.0175801359888423 0.9999999999864712 0.0989641929333703 5 P49327,Q13546,Q9Y5V3 3 +Peptide ligand binding receptors 0.8096991798445393 2.3722210975563747 0.0176815065555295 0.9999999999883044 0.0989641929333703 7 P05067,P42892,P07602 3 +Class a 1 rhodopsin like receptors 0.8096991798445393 2.3722210975563747 0.0176815065555295 0.9999999999883044 0.0989641929333703 7 P05067,P42892,P07602 3 +Selective autophagy 0.5572784196144246 2.355408207644282 0.018502367688268 0.9999999999964048 0.1019700914510012 35 P54646,Q9NS69,Q15388,O95613,Q13315,Q9UBN7,P21796,Q8N4H5 8 +O linked glycosylation 0.7769592690284637 2.3238337072402877 0.0201344084033501 0.9999999999996564 0.1049571341939486 5 Q8N4A0,Q10472,O43505 3 +Caspase activation via death receptors in the presence of ligand 0.7080292751447645 2.3217468651013107 0.0202465698534664 0.9999999999997076 0.1049571341939486 3 P49327 1 +Regulation by c flip 0.7080292751447645 2.3217468651013107 0.0202465698534664 0.9999999999997076 0.1049571341939486 3 P49327 1 +Phosphorylation of emi1 0.7041143857601238 2.3018685173062865 0.0213425881282713 0.9999999999999396 0.1083251505359386 3 P14635,P06493 2 +Cdc6 association with the orc origin complex 0.701196381674912 2.2870220203007063 0.0221945378310064 0.9999999999999823 0.1106285542952506 3 Q9Y619,Q9UBD5 2 +Wax and plasmalogen biosynthesis 0.7678552447477923 2.2811363915975007 0.022540377287894 0.9999999999999892 0.1108169768404825 5 Q6IAN0,O15228,O00116 3 +Metabolism of steroid hormones 0.7968050451590813 2.2772730847955276 0.0227699231666271 0.9999999999999925 0.1110201187658384 6 Q14849,P30536 2 +Activation of smo 0.6972026710961943 2.2666609691864994 0.0234109444755081 0.999999999999997 0.1127400773206213 3 P48729 1 +Biological oxidations 0.5046570978451571 2.262406360848069 0.0236723082974121 0.999999999999998 0.1128672401361952 48 P78417,Q8TB61,O43169,Q9NUJ1,Q16850,P07099,O15217 7 +Coenzyme a biosynthesis 0.6586931155192577 2.2623251246366576 0.0236773232319729 0.999999999999998 0.1128672401361952 2 Q13057 1 +Dna damage reversal 0.7337077708207842 2.2579843120840835 0.0239466375136547 0.9999999999999986 0.1137666852921444 4 Q9H1I8,Q8N3C0 2 +Transport to the golgi and subsequent modification 0.456910541854565 2.249124758937437 0.0245045597387507 0.9999999999999992 0.1155031505280937 82 O95249,Q9Y3B3,P24390,Q9Y678,P62820,O75396,Q16706,Q9BVK6,Q9Y6B6,Q9HCU5,Q13190,O95487,O43731,P49755,P04350,Q13409,P18085,Q96PC5,O75935,Q14789,Q9UJW0,O60512,O15498,Q12907,Q15363,O60476 26 +Metabolism of porphyrins 0.7625928733250693 2.228661786138729 0.0258364166725999 1.0 0.1195251931968476 9 P30519,P09601 2 +Gastrin creb signalling pathway via pkc and mapk 0.781063153308254 2.2052759537927935 0.0274347361537619 1.0 0.1252764165467898 6 P51812 1 +Iron uptake and transport 0.6432181839778377 2.191758647857355 0.0283969384691775 1.0 0.1292518715484178 18 P30519,Q9Y487,P09601 3 +Glycogen storage diseases 0.7191056957691795 2.1865479313167366 0.0287755419876696 1.0 0.1305539863170477 4 P46976,P10253 2 +Class i peroxisomal membrane protein import 0.7614809837614943 2.1848280107939653 0.0289014594360388 1.0 0.1307049976418294 8 O43808,Q9NR77,Q8TB36,P51648 4 +Ire1alpha activates chaperones 0.5751011070898802 2.1694427009555417 0.0300490900731014 1.0 0.1346715796606574 26 P49748,O14773,Q9Y5M8,O43731,P43307 5 +Vitamin b5 pantothenate metabolism 0.7155844400217168 2.169234549816701 0.0300648813558519 1.0 0.1346715796606574 4 P49327,Q9NRN7 2 +Sialic acid metabolism 0.7716173004999859 2.161791789009611 0.0306342286773404 1.0 0.1347189725036684 6 P16278 1 +Diseases of mismatch repair mmr 0.676101546542173 2.15828725839401 0.030905504750716 1.0 0.1350082575952333 3 P52701,P43246 2 +Alpha oxidation of phytanate 0.712796317398722 2.1555020243908873 0.0311225703811734 1.0 0.1355368728636907 4 O43808,P51648 2 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.7216647836719455 2.109450871526052 0.0349056823762539 1.0 0.1465830887883758 11 P05067,Q13190,P51648,P09601,O43681,P46379 6 +Er to golgi anterograde transport 0.4457365944353196 2.1066405722685757 0.0351487470735241 1.0 0.1467942002056263 78 O95249,Q9Y3B3,P24390,Q9Y678,P62820,O75396,Q9BVK6,Q9Y6B6,Q9HCU5,Q13190,P49755,O95487,O43731,P04350,Q13409,P18085,Q96PC5,O75935,Q14789,Q9UJW0,O15498,Q12907,Q15363 23 +Keratan sulfate keratin metabolism 0.7503032179411874 2.062897862952904 0.0391223332158596 1.0 0.1520705569354765 6 P16278,O60512 2 +Aurka activation by tpx2 0.5008211864921012 2.0443921494165727 0.0409148222487665 1.0 0.1564520709837657 39 Q15154,P41208,O94927,O95613,O95684,P06493,Q13409,O43805,Q96SN8,P43034,O75935,O14965 12 +Cytosolic sulfonation of small molecules 0.7172226342778429 2.0398380199729544 0.0413664616370073 1.0 0.1572510385222904 5 Q8TB61 1 +Cholesterol biosynthesis 0.617295289501288 2.0360444113141893 0.0417458958904892 1.0 0.1572510385222904 18 Q15392,O76062,Q15800,Q9UBM7,Q16850,Q14534,P48449,Q14739,P37268 9 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.4547090766192421 2.0357579342238283 0.0417746684009834 1.0 0.1572510385222904 63 Q9P032,P14854,Q9P0J0,Q7L592,O43676,Q16134,P06576,P21912,O75964,P13073,P24539,Q86Y39,P47985,P56385,P03886,O14949,Q9Y6M9,P00403,Q9UDW1,P22695,P51970,Q9NPL8 22 +Abc transporters in lipid homeostasis 0.6166861143523873 2.033981638221527 0.0419534468124911 1.0 0.1574370038628324 2 P40855 1 +Ptk6 regulates proteins involved in rna processing 0.6143523920653532 2.0211264064404197 0.0432666814498112 1.0 0.1607790503974465 2 P23246 1 +Small interfering rna sirna biogenesis 0.6764523386777623 1.9745866718780107 0.0483150727976986 1.0 0.1704314192938819 4 O75569,Q15631 2 +Intra golgi and retrograde golgi to er traffic 0.4232181795157879 1.9666103528017975 0.0492281490153092 1.0 0.1723595986615418 95 O95249,Q9Y3B3,P24390,Q6NUQ1,O00461,Q8TBA6,Q9Y678,P62820,O75396,Q16706,Q9BVK6,Q14204,Q13190,P43034,O43731,P49755,A2RRP1,Q10472,Q10471,O15260,P04350,Q15042,Q13409,P18085,O75935,Q9UJW0,O15498,Q9P2W9,Q15363,O60476 30 +N glycan antennae elongation in the medial trans golgi 0.6296385622102156 1.915012193688856 0.0554909485679502 1.0 0.1886692251310307 3 O60512 1 +Other interleukin signaling 0.6179971361569863 1.8530880784826336 0.0638697352725672 1.0 0.2120475211049231 3 Q13277 1 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.6776295424904719 1.8467191867575048 0.064787849456255 1.0 0.2135879803335884 5 P12236,P12235 2 +Recruitment of mitotic centrosome proteins and complexes 0.4716890788290272 1.8341398444943868 0.0666332381901921 1.0 0.2175387321493533 40 Q15154,P41208,O94927,O95613,O95684,P06493,Q13409,O43805,Q96SN8,P43034,O75935 11 +Respiratory electron transport 0.4443642300528869 1.8322281649307857 0.066917434348084 1.0 0.2175587554496465 54 P47985,Q9P032,P03886,P14854,P22695,Q7L592,Q9UDW1,P51970,P13073,Q86Y39,O14949,Q9P0J0,Q9Y6M9,P00403,Q9NPL8,O43676,Q16134,P21912 18 +Regulation of plk1 activity at g2 m transition 0.4641178057936057 1.8271647048747348 0.0676750089126623 1.0 0.2190124715040516 44 Q15154,P41208,O95067,O94927,O95613,O95684,P14635,P06493,Q13409,O43805,Q96SN8,P43034,O75935,O14965 14 +Phase i functionalization of compounds 0.6075999476779881 1.8257253471066677 0.0678916431591003 1.0 0.2192107745937999 15 Q16850,O43169,P07099 3 +Synthesis of gdp mannose 0.6118285365907993 1.820124244978835 0.0687400861920553 1.0 0.2214435196734932 3 Q9Y5P6 1 +Cargo concentration in the er 0.6038167284345113 1.803647181577429 0.0712866345822262 1.0 0.2275688719355685 15 O75396,Q9Y6B6,Q12907,Q9HCU5,Q13190,Q15363,P49755,O95487,Q96PC5 9 +Copi dependent golgi to er retrograde traffic 0.4420185285063753 1.7784695017982786 0.0753267766193233 1.0 0.2343774894186429 52 Q9Y3B3,P24390,O15260,Q9BVK6,Q9P2W9,Q15363,P49755,O43731 8 +Mapk targets nuclear events mediated by map kinases 0.6711204420466206 1.778372576286459 0.0753426836424258 1.0 0.2343774894186429 9 P51812 1 +Erk mapk targets 0.6711204420466206 1.778372576286459 0.0753426836424258 1.0 0.2343774894186429 9 P51812 1 +Diseases of carbohydrate metabolism 0.6633181231144931 1.773699487225103 0.0761128713149874 1.0 0.2360335415943896 10 P54802,P16278 2 +Phase ii conjugation of compounds 0.4937526048975363 1.7540704114295136 0.079418442920526 1.0 0.243079008591892 31 Q8TB61,O15217,Q9NUJ1,P78417 4 +Activation of ampk downstream of nmdars 0.6785261306997838 1.7511611530344104 0.0799181548635841 1.0 0.2440790400703835 7 P54646,P54619 2 +Unwinding of dna 0.6587045408145675 1.750039356550158 0.0801115228062456 1.0 0.2441411634548869 10 Q9Y248,Q14691,Q14566 3 +Smac xiap regulated apoptotic response 0.5974001246472456 1.7426250052435412 0.0813991392445427 1.0 0.2451234106755423 3 P42574 1 +Metabolism of folate and pterines 0.6669847299626351 1.724949676741363 0.0845365419232497 1.0 0.2495419678947812 8 P00374 1 +Synthesis of pa 0.6323210933656531 1.7196366847662954 0.0854985034682078 1.0 0.2518546730556185 12 Q8N2A8,Q9NPH0,O15228,Q9NUQ2,Q8NAN2 5 +Antigen activates b cell receptor bcr leading to generation of second messengers 0.5914794280711898 1.7106674462450242 0.0871425204610019 1.0 0.2556301379843528 3 P16885,O43865 2 +Golgi to er retrograde transport 0.4089889251160141 1.6924143319299492 0.0905670016113977 1.0 0.2613293236680618 75 Q9Y3B3,P24390,Q6NUQ1,Q9Y678,P62820,O75396,Q9BVK6,Q14204,P43034,O43731,P49755,A2RRP1,Q10472,Q10471,O15260,P04350,Q15042,Q8N6H7,Q13409,P18085,O75935,Q9UJW0,Q9P2W9,Q9Y496,Q15363 25 +Recruitment of numa to mitotic centrosomes 0.4494885069335445 1.6817072351041504 0.0926256243767367 1.0 0.2660364800468449 43 Q15154,P41208,O94927,O95613,O95684,P06493,Q13409,O43805,Q96SN8,P43034,O75935 11 +Transport of inorganic cations anions and amino acids oligopeptides 0.6505843550420247 1.6744918791212762 0.0940339690937315 1.0 0.2660553087682439 9 Q70HW3,Q9UBX3,P30825 3 +Transport of vitamins nucleosides and related molecules 0.6622177805732908 1.6711898102068237 0.0946841923098773 1.0 0.2660553087682439 7 Q8TB61,P12235 2 +Displacement of dna glycosylase by apex1 0.5519253208868286 1.6709954260124131 0.0947225812716823 1.0 0.2660553087682439 2 P13051 1 +Platelet calcium homeostasis 0.6145982729448608 1.6589266388582895 0.0971305759754574 1.0 0.2660553087682439 4 P16615 1 +Reduction of cytosolic ca levels 0.6145982729448608 1.6589266388582895 0.0971305759754574 1.0 0.2660553087682439 4 P16615 1 +The nlrp3 inflammasome 0.6395385457043198 1.657504050797321 0.0974176105851765 1.0 0.2660553087682439 5 P09601 1 +Purinergic signaling in leishmaniasis infection 0.6395385457043198 1.657504050797321 0.0974176105851765 1.0 0.2660553087682439 5 P09601 1 +Inflammasomes 0.6395385457043198 1.657504050797321 0.0974176105851765 1.0 0.2660553087682439 5 P09601 1 +Diseases associated with glycosylation precursor biosynthesis 0.6396118065540425 1.6516014553168228 0.0986158231649834 1.0 0.2660553087682439 10 P16278 1 +Cytoprotection by hmox1 0.4123314823004129 1.6407816873789194 0.1008427409471757 1.0 0.2689775188591019 66 P30519,P60900,P28072,P09601,Q8TCT9,P13073,P61289,P28074,P49721,P00403 10 +Diseases of glycosylation 0.5359597403254895 1.6349220955535853 0.1020653798917963 1.0 0.2717250019383483 20 P16278,Q96L58,P10619,Q9BT22,O43505 5 +Gpcr ligand binding 0.6316182023390808 1.6101484956582408 0.1073654421536434 1.0 0.280078402196344 10 P05067,P42892,P07602 3 +Dna replication initiation 0.6550817757009428 1.6086284757099818 0.1076976038505139 1.0 0.280078402196344 6 P49643,Q9NRF9,Q9NR33,P49642,Q07864 5 +G2 m dna replication checkpoint 0.596953852196825 1.5672749470757108 0.1170504386832629 1.0 0.2954528962112415 4 P14635,O95067 2 +Anchoring of the basal body to the plasma membrane 0.4437942044195837 1.5602698048464378 0.1186961357846814 1.0 0.2990718707003312 39 Q15154,P41208,O94927,O95613,O95684,P06493,Q13409,O43805,Q96SN8,P43034,O75935 11 +Phospholipid metabolism 0.4253425564191746 1.5581437658862918 0.1191991718668279 1.0 0.2998039777256581 49 Q8N2A8,Q9NPH0,O15228,Q9NUQ2,Q8NAN2,Q8TBX8,Q8IV08,Q8NCC3,P48651,Q96N66 10 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.6121937446083104 1.5421800096389655 0.1230298564276202 1.0 0.3077927791123619 11 P15289,P38435,O60725 3 +Glycerophospholipid catabolism 0.5256709451575425 1.5205068025451256 0.1283836503759685 1.0 0.3175389287687443 2 Q8IY17 1 +Sensing of dna double strand breaks 0.61152127007521 1.5164369716848565 0.1294088963448638 1.0 0.3181114159278796 5 P52292 1 +Activation of nmda receptors and postsynaptic events 0.4765359345575823 1.50980055533189 0.1310943233200072 1.0 0.321456081815285 27 P51812,P52292,Q15418 3 +Pyroptosis 0.6099706013866057 1.5085883176676764 0.131404021447882 1.0 0.321456081815285 5 Q07812,P09429 2 +Cilium assembly 0.3956467086997702 1.5042745563486315 0.1325106875827391 1.0 0.3222287495768824 69 Q15154,A0AVF1,P41208,O94927,O95613,O95684,Q92973,P06493,Q13409,Q9UBN7,A6NIH7,O43805,Q9H6D7,Q96KP1,Q96SN8,P43034,P18085,O75935 18 +Organelle biogenesis and maintenance 0.3781451090045858 1.5004723113880694 0.1334921006000513 1.0 0.3222287495768824 104 P54646,Q15154,O95684,A6NIH7,O43805,Q9BUR5,P06576,O75964,Q9Y512,O95613,Q9UBN7,P43034,P24539,P56385,A0AVF1,P41208,Q6UXV4,Q13505,P06493,Q92973,Q13409,Q96SN8,P18085,O75935,Q5XKP0,O94927,Q9H6D7,Q96KP1,O60645 29 +Asparagine n linked glycosylation 0.3570676181917586 1.4991902965829582 0.1338242716173303 1.0 0.3222287495768824 127 O95249,Q9Y3B3,P24390,Q2TAA5,P62820,Q16706,P16278,Q9BVK6,Q9Y6B6,Q9HCU5,Q13190,Q86YN1,O95487,O43731,P49755,Q9Y5P6,P04350,Q13409,Q9BUN8,P18085,Q96PC5,O75935,Q14789,Q9UJW0,P46977,O60512,Q12907,Q15363,P10619,Q9BT22,O60476 31 +Glycerophospholipid biosynthesis 0.4636666963557519 1.4981404522055384 0.1340967629951457 1.0 0.322334808494294 30 Q8N2A8,Q9NPH0,O15228,Q9NUQ2,Q8NAN2,Q8IV08,Q8NCC3,P48651 8 +Nuclear events kinase and transcription factor activation 0.5898470156663345 1.488814832542457 0.1365361353805123 1.0 0.3248777184180487 12 P50570,P51812,Q15418 3 +Role of lat2 ntal lab on calcium mobilization 0.5198366394399168 1.48685075932032 0.1370542318184053 1.0 0.3255614833262121 2 P62993 1 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.6038431120246406 1.465119956323481 0.1428881928633314 1.0 0.3354662897340443 10 P51812 1 +Synthesis of very long chain fatty acyl coas 0.6185679085947257 1.4546667011016556 0.14576155542081 1.0 0.3386145279148547 7 Q53GQ0,Q9P035 2 +Prevention of phagosomal lysosomal fusion 0.5385721419269534 1.4215728222051696 0.1551502991999367 1.0 0.3502673154737771 3 O14964 1 +G1 s specific transcription 0.5747113121244021 1.4056481712714082 0.1598286242900135 1.0 0.3562688607791613 12 Q9Y619,P04818,P00374 3 +Srp dependent cotranslational protein targeting to membrane 0.3783629333886497 1.398538941102382 0.1619512873797282 1.0 0.3598634117996795 90 P46781,P46778,P26373,P62753,P62910,P46779,P46776,P43307,P84098,P62841,P67812,O76094,Q9Y3U8,Q15005,Q9Y5M8,Q07020,P83731,P27635,P42766,P62917,P61353,P62424,P62266,P47914,P61513,P62701,Q15629,P61927,P83881,P62277,P36578,Q02878,P62847,P39023,P62269,P62750,P51571 37 +Nef and signal transduction 0.4962077012835549 1.3499057088193895 0.177046230266431 1.0 0.3837361457848452 2 Q13177 1 +Signaling by erbb4 0.5895680988466786 1.3340246233551711 0.182195786884735 1.0 0.3923989374731967 8 Q15334,Q96J02,P46934,P61201,Q92542 5 +Neutrophil degranulation 0.3166353358944161 1.3316059028891722 0.1829897242079117 1.0 0.3923989374731967 179 P30519,Q07065,P15289,P01889,O75165,Q93050,P51665,P46976,P06280,P15586,P17931,Q7L576,Q99436,P11279,Q5T9A4,Q13510,Q7Z6Z7,P16278,P61026,Q13442,Q14204,Q9H7Z7,P42785,Q8NF37,O14975,O43681,P04439,Q99536,O00231,Q92542,P61020,O00560,P09429,P13473,O15260,Q9NQX7,O43242,P07602,Q969Q5,O00584,Q4KMQ2,Q92820,O00264,P10253,P20618,P17900,Q9BRF8,Q9BTY2,P10619,Q9Y5K8,Q9NZJ7,Q5T4S7 52 +Cellular response to chemical stress 0.3753529292683374 1.3138912185785452 0.1888828142750451 1.0 0.3989725313504322 76 P30519,P60900,P28072,P09601,Q8TCT9,P32119,P61289,P13073,P49721,P28074,P00403 11 +Recycling of eif2 gdp 0.5895679000328065 1.3092308046690724 0.1904561805079798 1.0 0.4016945750325255 7 P49770 1 +The citric acid tca cycle and respiratory electron transport 0.3654225493050336 1.2898062530359569 0.1971179363228887 1.0 0.4126608429548902 98 P35613,P53985,Q13423,Q9P032,P14854,P21796,Q9P0J0,Q7L592,O43676,Q16134,P21912,P06576,O75964,O43708,P13073,P24539,Q86Y39,P47985,P56385,P03886,O14949,Q9Y6M9,P00403,Q9UDW1,P22695,P51970,Q9NPL8 27 +Intra golgi traffic 0.5162516375645301 1.2814326521143775 0.2000417413976807 1.0 0.4175427472072892 15 O95249,Q8TBA6,O00461 3 +Metabolism of fat soluble vitamins 0.5648797054022336 1.278912689584851 0.2009278035468658 1.0 0.4181550601838166 5 Q8N0U8 1 +Cristae formation 0.4884578648522384 1.271627751205764 0.2035054118270314 1.0 0.4204189400994748 19 O75964,P56385,Q9Y512,Q5XKP0,Q13505,Q9BUR5,P24539,P06576 8 +Chondroitin sulfate dermatan sulfate metabolism 0.5379541300899349 1.257050323563375 0.2087354136503063 1.0 0.4243885715570349 4 Q96L58 1 +Lipophagy 0.5365525892498707 1.2496343822860638 0.211433137337309 1.0 0.4286563324342974 4 P54646 1 +Nuclear signaling by erbb4 0.5361305716193157 1.2474011625555177 0.2122504405030654 1.0 0.4296777210184007 4 P61201,Q92542 2 +Rnd1 gtpase cycle 0.503768345744602 1.2427346470573946 0.2139656320266558 1.0 0.4315010933834751 16 O43396,P51648 2 +Polb dependent long patch base excision repair 0.5804120586026831 1.2410528496708904 0.2145862260016207 1.0 0.4319274820089683 6 Q9UGN5 1 +Plasma lipoprotein clearance 0.5325177597791328 1.2353165223321727 0.2167127269656048 1.0 0.433732847870168 13 Q8WTV0 1 +Runx3 regulates p14 arf 0.4746207701283652 1.2241708166235972 0.2208877957691311 1.0 0.4395947529340535 2 P25440 1 +Tp53 regulates transcription of genes involved in cytochrome c release 0.5289412312000327 1.209344873523439 0.2265303778675536 1.0 0.4451951008761065 4 Q13315 1 +Mastl facilitates mitotic progression 0.5668737104335988 1.1738592147082647 0.2404514211200057 1.0 0.4656759221497983 6 P14635,P06493,Q96GX5 3 +Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 0.4862275786424016 1.131520476225082 0.2578360900591774 1.0 0.4876765724845835 3 Q96T60 1 +Processing of smdt1 0.5386884091070185 1.1207109828319073 0.2624109056986392 1.0 0.4899262451834908 10 Q8IYU8,Q99623,Q8NE86 3 +Fatty acyl coa biosynthesis 0.5012168111591305 1.1201903198227166 0.2626326681646937 1.0 0.4899262451834908 14 P49327,Q53GQ0,Q9P035,O00767,P50897 5 +Energy dependent regulation of mtor by lkb1 ampk 0.5519432322210408 1.1195724899282462 0.2628959841138647 1.0 0.4899262451834908 7 P54646,P42345,Q15382 3 +Ros and rns production in phagocytes 0.5413531774510455 1.1098864228294802 0.2670479718273686 1.0 0.4912707799848984 9 Q9Y487 1 +Phosphorylation of the apc c 0.5211652462276648 1.1090599180120897 0.2674043345307408 1.0 0.4912858281547856 12 Q9H1A4,Q9UJX4,Q9UJX3,P06493,P14635,Q16763,P53350,Q13042,P30260 9 +Vxpx cargo targeting to cilium 0.5388964201430885 1.0970768271313158 0.2726078091047035 1.0 0.4990792557469027 9 Q96KP1,P18085,Q9UPT5,O60645 4 +Dopamine neurotransmitter release cycle 0.4524504084014041 1.0948764751221234 0.2735707566197027 1.0 0.4990792557469027 2 O14936 1 +Synthesis of pips at the golgi membrane 0.5439063251941756 1.0790461409325658 0.2805671590926826 1.0 0.5036644548088742 7 Q01968,Q9BTU6,O00443 3 +Regulation of hmox1 expression and activity 0.3769004468980765 1.063843501881996 0.2873996007810686 1.0 0.5133175148127694 47 P60900,P28072,P09601,Q8TCT9,P61289,P49721 6 +Nr1h2 and nr1h3 mediated signaling 0.5390511362738807 1.0545797805248462 0.2916175551981919 1.0 0.5175753086599355 7 P49327,Q9HCE1,O00767 3 +Interaction between l1 and ankyrins 0.498540572095744 1.048448665895504 0.294431941695741 1.0 0.5209666261262068 4 Q12955,Q01082,O15020 3 +Phase 0 rapid depolarisation 0.4689232564925757 1.035577296855955 0.300399388132055 1.0 0.5271934535501612 3 Q9HD47,Q13555 2 +Response to elevated platelet cytosolic ca2 0.4007089805344818 1.0299301689082845 0.3030427873923267 1.0 0.530512869740165 32 P05067,P13473,Q8NBX0,P07602,O94919,Q9NZJ7 6 +Apc c cdc20 mediated degradation of cyclin b 0.5129818311042343 1.0088969110424033 0.3130240767878756 1.0 0.5446078573954284 11 Q9H1A4,Q9UJX4,Q9UJX3,P14635,P06493,Q16763,Q13042,P30260 8 +Sulfur amino acid metabolism 0.4978579832625099 0.9797441871218228 0.327212408575861 1.0 0.5616748278595376 12 Q9UBX3 1 +Telomere c strand synthesis initiation 0.5054091843025151 0.9745252196247496 0.3297958233162634 1.0 0.5626867070123914 5 Q15554,P49642,P49643 3 +Interleukin 4 and interleukin 13 signaling 0.4830945347116313 0.9529803799044544 0.3406000117046006 1.0 0.5776281448499898 13 P09601 1 +Inactivation of cdc42 and rac1 0.4534578348409812 0.9501741760511864 0.342023757932651 1.0 0.5781770716593876 3 P63000,O94813 2 +Fatty acid metabolism 0.3540250074403843 0.945135525838276 0.3445896903101304 1.0 0.5781770716593876 58 P54646,P49327,Q15067,Q16836,Q15165,P49748,Q53GQ0,Q9H7Z7,A8MXV4,O95864,P51648,O43808,O00767,P50897,O43772,P23786 16 +Synthesis of substrates in n glycan biosythesis 0.4389355003878535 0.9450926756012196 0.3446115643271048 1.0 0.5781770716593876 19 P10619,P16278 2 +Er quality control compartment erqc 0.4769410391126736 0.9346683011711652 0.3499592678047776 1.0 0.5864519321526618 4 Q9UBV2,Q9GZP9,Q13438 3 +Carnitine metabolism 0.516661359223166 0.9252314674426227 0.3548455184287569 1.0 0.5918286365283404 6 O43772,P23786 2 +Regulation of lipid metabolism by pparalpha 0.4115240265562905 0.9089899450826864 0.3633554333809834 1.0 0.5991652342675469 24 Q15067,P37268,Q06520,P23786 4 +Complex i biogenesis 0.3894995197327912 0.9087428628301528 0.3634858730566153 1.0 0.5991652342675469 30 Q9P032,P03886,P51970,Q9Y6M9,Q9NPL8,Q9P0J0,O43676,Q86Y39 8 +Response of eif2ak4 gcn2 to amino acid deficiency 0.3404636341540353 0.9079296651585228 0.3639153832510897 1.0 0.5991652342675469 75 P46781,P46778,P62753,P26373,P62910,P46779,P46776,P84098,P62841,P20042,Q92616,Q9Y3U8,Q07020,P83731,P27635,P42766,P62917,P61353,P62266,P47914,P62424,P61513,P62701,P61927,P83881,P62277,P36578,Q02878,P62847,P39023,P62269,P62750 32 +Stimuli sensing channels 0.4966260444625672 0.8982115763668674 0.3690727628518764 1.0 0.6048335289012748 10 Q13546,Q96BR1,Q9C0H2,Q4KMQ2,P51798 5 +Formation of atp by chemiosmotic coupling 0.4997796383123667 0.8938556375109921 0.371399136189122 1.0 0.6065326170866333 9 P24539,O75964,P56385 3 +Plasma lipoprotein assembly remodeling and clearance 0.434509410968849 0.8791519333854768 0.3793189023568684 1.0 0.6145000513087862 18 O15118,Q8WTV0 2 +Insulin receptor recycling 0.4928520197759989 0.8783823679441028 0.3797362496794005 1.0 0.6145000513087862 10 Q9Y487 1 +Unfolded protein response upr 0.3625750364092195 0.8783350821186928 0.3797619027223682 1.0 0.6145000513087862 42 P49748,O14773,Q9Y5M8,O43731,P43307 5 +Signaling by insulin receptor 0.4447487722281215 0.8773559810304772 0.3802933144717619 1.0 0.6146550592435924 16 Q9Y487 1 +Arms mediated activation 0.43974321564052 0.8749229044210604 0.3816158555951117 1.0 0.6160595894412788 3 P46108,Q9ULH0 2 +Mtor signalling 0.4688653652779584 0.8721409089144339 0.3831315111476308 1.0 0.6165147394642747 13 P54646,P42345,Q15382,P23588,P62753,P54619 6 +Ub specific processing proteases 0.3372094981197732 0.8716752094038588 0.3833855881582344 1.0 0.6165147394642747 79 Q15388,Q9Y277,P60900,P28072,P14735,P45880,P21796,P61289,P49721,P28074,Q9UPU5 11 +Golgi cisternae pericentriolar stack reorganization 0.4782004530984926 0.8712299854567599 0.3836285905383652 1.0 0.6165147394642747 12 P62820,P14635,P06493,O95067 4 +Rnd2 gtpase cycle 0.4312144212078768 0.8580110296899593 0.3908863730337266 1.0 0.6234030427476308 18 Q07065,O43396,P51648 3 +Gap junction assembly 0.4791240875912451 0.8413323099657997 0.4001617948841149 1.0 0.6328350766872235 5 Q9BUF5,P04350,P68371,Q13885 4 +Transport of connexons to the plasma membrane 0.4791240875912451 0.8413323099657997 0.4001617948841149 1.0 0.6328350766872235 5 Q9BUF5,P04350,P68371,Q13885 4 +Glutathione conjugation 0.4364653359332952 0.8264688869566206 0.4085381603291926 1.0 0.642639179737448 16 P78417 1 +Arachidonic acid metabolism 0.4886718528902504 0.8188001115146225 0.412900467315072 1.0 0.6459022996197213 8 Q15165 1 +Mismatch repair 0.4686404125360326 0.8187984784624741 0.4129013991899282 1.0 0.6459022996197213 12 Q9UQ84 1 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.42399883106922 0.8118382866915347 0.416884429704667 1.0 0.6485379606541181 18 Q07065,Q02818,P05067,Q9BTY2 4 +Rhog gtpase cycle 0.3564573592006286 0.8091573437153672 0.4184246474196462 1.0 0.6502171558470494 40 O15498,O96013,P50402,Q86XL3,Q13190,Q8TAA9,Q7L576,O15173,Q14739,O95202,P42167 11 +Apoptosis induced dna fragmentation 0.4743829648646112 0.7819366218911348 0.4342518212811257 1.0 0.668189007445658 10 P09429,P16402,P10412,P16403,P42574 5 +Transferrin endocytosis and recycling 0.4703176841871029 0.7807013596629538 0.4349781607524898 1.0 0.668577543378827 11 Q93050,Q9Y5K8,Q15904,Q9Y487 4 +Wnt mediated activation of dvl 0.4201925882696399 0.7688708240662305 0.4419699991367658 1.0 0.6763770811084344 3 P19784,P68400 2 +Rhoa gtpase cycle 0.3377250870037296 0.7635775805661474 0.4451190137956602 1.0 0.6796482449267368 55 P30519,Q92974,Q13190,Q8TAA9,Q8NBN3,O15173,Q14739,Q96HY6,P42167 9 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.4805646355602106 0.7628939830039337 0.4455266249207299 1.0 0.6796482449267368 7 Q16850 1 +Resolution of d loop structures 0.477186281668828 0.7612363814129345 0.446515891599635 1.0 0.6796482449267368 8 Q9UQ84 1 +Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.477186281668828 0.7612363814129345 0.446515891599635 1.0 0.6796482449267368 8 Q9UQ84 1 +Heme biosynthesis 0.4818752637472976 0.755684727871487 0.4498382427636307 1.0 0.6817634377438055 6 Q7KZN9 1 +Carboxyterminal post translational modifications of tubulin 0.4747297692083045 0.7343531489830994 0.4627335330882505 1.0 0.6953322845447513 7 Q9UPW5,P04350,P68371,Q9BUF5,Q9BVA1,Q13885 6 +Mitochondrial biogenesis 0.3588700114715964 0.7324526251622572 0.4638923484272319 1.0 0.6955743227773767 35 P54646,O75964,P56385,Q9Y512,Q5XKP0,Q6UXV4,Q13505,Q9BUR5,P24539,P54619,P06576 11 +Activation of nima kinases nek9 nek6 nek7 0.4563879924769128 0.7279441937927782 0.4666477485709128 1.0 0.6967428021065531 5 P14635,O95067 2 +Rac2 gtpase cycle 0.3471977595932645 0.7257540553694269 0.4679895572669104 1.0 0.6967428021065531 40 Q13505,Q86XL3,Q8TAA9,O15173,Q14739,P42167 6 +P130cas linkage to mapk signaling for integrins 0.381563593932325 0.688913822871659 0.4908775001894581 1.0 0.7192400340262984 2 P46108 1 +Copi independent golgi to er retrograde traffic 0.3640282528438454 0.6861306086315219 0.4926307507705771 1.0 0.7210601549141954 28 Q10472,Q10471,Q9H2M9,Q9UJW0,P04350,Q14204,Q15042,Q13409,Q8TD16,Q14203,P43034,O75935,P68402 13 +G alpha i signalling events 0.3715672876393117 0.6787364010460538 0.4973048974654241 1.0 0.7241457278882493 26 P05067,P52292,P07602 3 +Interleukin 17 signaling 0.3964171127005846 0.6680887319772272 0.5040769540827803 1.0 0.7260358357315614 19 P51812 1 +Neurotransmitter receptors and postsynaptic signal transmission 0.3387149071434398 0.649773518728424 0.5158385267606147 1.0 0.7393533029325228 40 P51812,P52292,Q15418 3 +Antigen presentation folding assembly and peptide loading of class i mhc 0.3916317419719428 0.6375181005015627 0.5237874236354778 1.0 0.7467365484938296 19 Q03519,P01889,Q9Y6B6,Q9NZ08,Q03518,P04439,O95487 7 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.376962857981714 0.6367529313185438 0.5242857896438737 1.0 0.7467365484938296 23 P10619,Q9BT22,Q86YN1,P16278 4 +Mitotic g2 g2 m phases 0.3116438230872063 0.6364824340711482 0.5244620266175657 1.0 0.7467365484938296 104 Q15154,O95684,P51665,P14635,O43805,P61289,Q99436,P60900,O95613,P49721,P43034,P41208,O95067,P28072,P04350,P06493,O43242,Q13409,P28074,Q96SN8,Q92530,O75935,O14965,P20618,O94927,Q9H6D7 26 +Formation of senescence associated heterochromatin foci sahf 0.4486242864460602 0.6343852830210475 0.5258294117104607 1.0 0.7479287297615524 9 P16403,P16402,P10412 3 +Pi metabolism 0.384802241492406 0.6255016844935677 0.5316418431884071 1.0 0.7525853212832632 20 Q9Y217,Q01968,Q9NTJ5,Q8TBX8,Q9BTU6,P48739,O00443 7 +Receptor mediated mitophagy 0.416520723876247 0.6247792636677262 0.5321159421873007 1.0 0.7525853212832632 4 P67870,P19784,P68400 3 +Response of eif2ak1 hri to heme deficiency 0.392471549460186 0.6223063057871249 0.5337404756035888 1.0 0.7538616727494132 3 P20042,P05198 2 +Chaperone mediated autophagy 0.4435283013034208 0.6092730387965495 0.542343474757498 1.0 0.7644821607221076 9 O95613,P13473 2 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.4418912576872951 0.6012442632200901 0.5476773069393586 1.0 0.7704612962028266 9 Q9H1A4,Q9UJX4,Q9UJX3,Q16763,Q13042,P30260 6 +Activation of gene expression by srebf srebp 0.3854925086294518 0.5985702581229013 0.5494594943296776 1.0 0.770502519892656 19 P49327,O76062,Q9UBM7,Q16850,Q14534,P48449,P37268,O75845 8 +Post chaperonin tubulin folding pathway 0.4362074761734258 0.5874711595881941 0.5568873144808637 1.0 0.7779881195371274 10 Q99426,P04350 2 +Toll like receptor tlr1 tlr2 cascade 0.3688017932986684 0.5807699352489506 0.5613955203137921 1.0 0.7814205547052527 23 P51812,Q15418 2 +Synthesis of pips at the plasma membrane 0.4163169023427098 0.5805266929279448 0.56155949147493 1.0 0.7814205547052527 13 Q9Y217,Q01968,Q8TBX8,Q9BTU6,O00443 5 +Eukaryotic translation elongation 0.3114451950163898 0.5682900343984228 0.5698380447394911 1.0 0.785964302177343 76 P46781,P46778,P62753,P26373,P62910,P46779,P46776,P84098,P62841,Q9Y3U8,Q07020,P83731,P27635,P42766,P62917,P61353,P62266,P47914,P62424,P61513,P62701,P61927,P83881,P62277,P36578,Q02878,P62847,P29692,P39023,P62269,P62750 31 +Cytosolic iron sulfur cluster assembly 0.4411914047313675 0.5642544647204173 0.5725809660713927 1.0 0.7869539632430819 6 P28340,O75027 2 +Peroxisomal lipid metabolism 0.404951616071787 0.563133170596843 0.5733442056795806 1.0 0.7869539632430819 14 A8MXV4 1 +Abc transporter disorders 0.3257200011096751 0.5593138239319534 0.5759475625125874 1.0 0.7897589997135673 45 O14678,P60900,P28072,P61289,P49721,Q9BUN8 6 +Interleukin 27 signaling 0.379632331485275 0.5565689840862191 0.5778219498549111 1.0 0.7900259411291469 3 P42224,P27824 2 +Interleukin 35 signalling 0.379632331485275 0.5565689840862191 0.5778219498549111 1.0 0.7900259411291469 3 P42224,P27824 2 +Formation of incision complex in gg ner 0.3869816128562033 0.5533991186214025 0.5799901423218032 1.0 0.7914565675203716 17 P54725,P41208,P18074,P09874,P61088,Q9UGN5 6 +Regulation of cholesterol biosynthesis by srebp srebf 0.3497775549588791 0.5475458436724062 0.584003784091149 1.0 0.7946280996650059 27 P49327,O76062,Q9Y6B6,Q9UBM7,Q16850,Q14534,O00767,P48449,P37268,O75845 10 +Activation of the pre replicative complex 0.3716291531694199 0.5406136111459099 0.5887739342206331 1.0 0.798040366172251 20 Q99741,P49736,P25205,P49643,Q9Y619,Q9NRF9,Q9NR33,P33991,P33993,P49642,P33992,Q9UBD5,Q07864,Q14566 14 +Recycling pathway of l1 0.3658191917081116 0.5395973730837651 0.5894747286281135 1.0 0.798223456904288 22 P51812 1 +Diseases of dna repair 0.4215983313134629 0.5296333474888446 0.5963661686668786 1.0 0.8029783599225141 11 Q9UQ84 1 +Translation of sars cov 1 structural proteins 0.4320097216978371 0.5226227046306053 0.6012368372764949 1.0 0.8071790460486531 6 Q10472 1 +Rab geranylgeranylation 0.3654002897499259 0.5180289037403373 0.6044381030856223 1.0 0.8105445981118196 21 P62820,P61020,Q969Q5,Q15907,P61019,P20337 6 +Condensation of prometaphase chromosomes 0.4168126110694091 0.5059221356079606 0.6129113122303278 1.0 0.8166434229609554 11 P14635,O95067 2 +Regulation of tp53 expression and degradation 0.4193138298765383 0.5046294897023864 0.6138190933195928 1.0 0.8166434229609554 10 P42345,Q13315 2 +Synthesis of ip2 ip and ins in the cytosol 0.3688357163700191 0.5026492768772004 0.6152108775424909 1.0 0.8166434229609554 3 Q01968,Q9NPH2 2 +Nef mediated downregulation of mhc class i complex cell surface expression 0.3879159369527205 0.4867294261408968 0.6264500891329294 1.0 0.8269232390118026 4 P04439,Q10567,O43747 3 +Peptide hormone metabolism 0.3908066482243994 0.4858659281832804 0.6270622269451769 1.0 0.8269232390118026 14 P67812,Q9UPT5,Q15005,Q96KP1,O60645 5 +Methylation 0.4192160552601622 0.4819747057128898 0.6298239149690323 1.0 0.8272800967335004 8 P78417 1 +Amyloid fiber formation 0.4143303594426966 0.4806941261030086 0.6307339064696893 1.0 0.8272800967335004 10 Q9Y287 1 +Attachment of gpi anchor to upar 0.4037884437110514 0.4777975400336396 0.6327943121999973 1.0 0.8274380793045986 5 Q92643,O43292 2 +Association of tric cct with target proteins during biosynthesis 0.3653635042432502 0.4735333134201038 0.6358327396434846 1.0 0.828642391646541 19 P04062 1 +Synthesis of dna 0.3028068534062951 0.4645212125427381 0.6422743652858312 1.0 0.8352526538417583 83 Q9Y619,P51665,P61289,Q99436,P60900,Q9Y248,Q14691,P49721,Q14566,Q9H1A4,Q9UJX4,P28072,O43242,P28074,Q92530,Q16763,P20618,P35251,Q9NR33,Q9BRT9,P28340,Q07864 22 +Eukaryotic translation initiation 0.2992125077605227 0.4552920968638131 0.648899111196124 1.0 0.8390733123605594 100 P23588,P46781,P46778,P26373,P62753,P62910,P46779,P46776,P84098,P62841,P20042,Q9Y3U8,P49770,Q07020,P83731,P27635,P42766,P62917,P61353,P62081,P62424,P62266,P47914,P61513,P62701,P61927,P83881,P62277,Q9Y262,Q14152,P36578,P55010,Q02878,P62847,O60841,P39023,P62269,P62750 38 +Toll like receptor 9 tlr9 cascade 0.3437121531038313 0.4537214093661308 0.6500293554820626 1.0 0.8390733123605594 25 P51812,Q15418 2 +Potential therapeutics for sars 0.3234977995359012 0.4531197081809247 0.6504625446394936 1.0 0.8390733123605594 36 Q99720,P21964,P49354,P49356 4 +Synthesis of pips at the late endosome membrane 0.3586227020717929 0.4529784166491918 0.6505642832901857 1.0 0.8390733123605594 3 Q99570,O00443 2 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.398458621066535 0.4492748279709044 0.6532334139934717 1.0 0.8409784189277267 12 P09601 1 +Rhobtb3 atpase cycle 0.3788674839462998 0.4448841860190241 0.6564034514658965 1.0 0.8428902305970277 4 O14964,Q13618,Q15345 3 +Regulated necrosis 0.3720087554056926 0.4447360221425279 0.6565105339660762 1.0 0.8428902305970277 16 P49327,Q13546,P09429,O75955,Q07812,Q16543,P42574 7 +Abc family proteins mediated transport 0.3062739498378117 0.443436436994723 0.657450085506402 1.0 0.8433291551359393 53 P20618,P20042,Q9NUT2,Q92530,P60900,P28072,O75027,P51665,P61289,P28074,P49721,P08183,Q9BUN8,Q99436 14 +Scf skp2 mediated degradation of p27 p21 0.3145990144629803 0.4404545820582888 0.659607900216534 1.0 0.8445614765930395 41 P20618,P11802,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 10 +Translation of sars cov 2 structural proteins 0.3671515934249716 0.4373982293551175 0.6618225680197911 1.0 0.8466288698784453 17 Q16706,P46977,P48729,Q10472 4 +Regulation of runx3 expression and activity 0.3191339597884896 0.4306040162438089 0.6667563204263889 1.0 0.8506267342871924 37 P20618,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 9 +Dna strand elongation 0.3326744705765137 0.4237649619146943 0.6717372335200982 1.0 0.8548317699646173 27 Q9Y248,P28340,Q14691,Q14566 4 +Innate immune system 0.2724287285165627 0.4224983912003762 0.6726612747455634 1.0 0.8548317699646173 298 P30519,Q07065,Q93050,Q8IV08,P09601,P51812,Q9H2U1,P61289,Q13510,P16278,P60900,Q9H7Z7,P42785,P49721,Q99536,P13473,O15260,P28072,Q9NQX7,P07602,Q969Q5,P28074,O00264,Q15418,Q9Y487,Q9UQB8,P10253,P05067,P17900,Q9BRF8,P10619,Q9NZJ7 32 +Activation of rac1 0.3912408759124137 0.42192252139262 0.6730815708225995 1.0 0.8548317699646173 5 P63000,O96013,O94813,Q13177 4 +Cd28 dependent vav1 pathway 0.391240875912413 0.4219225213926182 0.6730815708226008 1.0 0.8548317699646173 5 P63000,P62993,P60953,Q13177 4 +Mitotic g1 phase and g1 s transition 0.29858399827242 0.4209051620163051 0.6738243356682592 1.0 0.8550055194495627 75 Q9Y619,P14635,P51665,P61289,Q99436,P60900,P00374,P49721,Q14566,P04818,P28072,P06493,O43242,P28074,Q92530,P20618,P11802,Q9NR33,Q07864 19 +Cdc42 gtpase cycle 0.3175593846168685 0.4176706221250633 0.6761879544089175 1.0 0.8564642761858013 37 Q96N67,Q9H8V3,O15498,O96013,P02786,Q8N6H7,Q6IAA8,Q8TAA9,A4D1P6,Q14739,Q9UQB8,P42167 12 +Purine ribonucleoside monophosphate biosynthesis 0.4016725419653396 0.4113634202402879 0.6808060722621296 1.0 0.8597114171834422 9 P31939 1 +Cdt1 association with the cdc6 orc origin complex 0.3112573779711226 0.4090808332667009 0.6824803415222078 1.0 0.8598793658767664 40 P60900,P28072,Q9Y619,P61289,P49721 5 +Rac3 gtpase cycle 0.3142864174749647 0.4043559296778878 0.6859510026632569 1.0 0.8634048748955 38 O15498,Q01968,O96013,P50402,Q8TAA9,O15173,Q14739,Q9UQB8,Q7L576,P42167 10 +Senescence associated secretory phenotype sasp 0.3472024993917207 0.4027638746150129 0.6871219392565839 1.0 0.8636251062419936 21 Q9H1A4,Q9UJX4,P11802,P51812,Q16763,Q15418 6 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.3945405424525596 0.3883540989645539 0.697754007437668 1.0 0.872116535696237 10 Q07812,P14635,O14965 3 +Hdr through mmej alt nhej 0.3976992949454713 0.3857984748201496 0.6996459249421654 1.0 0.8736286726490224 8 Q9UGN5 1 +Myd88 independent tlr4 cascade 0.3328469267743885 0.3800699363395165 0.7038935015541032 1.0 0.8766052345038303 25 P51812,Q15418 2 +Post translational modification synthesis of gpi anchored proteins 0.3958662335995276 0.3778624755538222 0.7055327595043286 1.0 0.8778718903532695 8 O43292,Q9ULX3 2 +Insulin processing 0.3907856062336434 0.3630191057316062 0.7165906121933256 1.0 0.886938029653318 9 Q96KP1,Q9UPT5,O60645 3 +Synthesis of pips at the early endosome membrane 0.3770628027202833 0.361181507970283 0.7179637649293136 1.0 0.8870813242690555 5 Q9BTU6 1 +Metabolism of carbohydrates 0.291449066688712 0.353199324498299 0.7239390142641191 1.0 0.8929003051806574 99 P16278,O60512,Q8TB61,Q9BTX1,Q96L58,Q9BRR6,P52789,Q7LGA3,Q9UBX3,P54802 10 +Cellular response to starvation 0.2929928100201494 0.3494838888129326 0.7267260640990056 1.0 0.894226610360643 87 P46781,P46778,P26373,P62753,P62910,P46779,P46776,P84098,P62841,P20042,Q15382,Q92616,Q9Y3U8,Q07020,P83731,P27635,P42766,P62917,P61353,P62424,P62266,P47914,P61513,P62701,P61927,P83881,P62277,P42345,P36578,Q02878,P62847,Q6IAA8,Q9Y5K8,P39023,P62269,P62750 36 +Mtorc1 mediated signalling 0.3856927702661568 0.3486725795904473 0.7273351321985384 1.0 0.894226610360643 10 Q15382,P23588,P42345,P62753 4 +The role of gtse1 in g2 m progression after g2 checkpoint 0.2983813215458497 0.3483872703665766 0.7275493612289285 1.0 0.894226610360643 51 P20618,O95067,P60900,P28072,P04350,P14635,P51665,P06493,P61289,P28074,P49721,Q92530,Q99436 13 +Copii mediated vesicle transport 0.316724706505987 0.3454590415259804 0.7297492971738677 1.0 0.895617875331026 30 P62820,Q9Y6B6,O15498,Q9HCU5,Q12907,Q13190,Q15363,O95487,P49755 9 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.3731386861313918 0.3448694739168645 0.7301925005949761 1.0 0.895617875331026 5 Q99570,P62993,O14654,O00459 4 +Antigen processing cross presentation 0.2961080061694543 0.3443467579874997 0.7305855241006456 1.0 0.895617875331026 53 P20618,P09429,Q03519,P01889,Q92530,P60900,P28072,P51665,Q9UIQ6,P61289,P28074,P49721,Q03518,P04439,Q99436 15 +Stabilization of p53 0.3020961265793953 0.3315932789724893 0.7401963953152029 1.0 0.9019146060360546 40 P60900,P28072,Q13315,P61289,P49721 5 +Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.369124264369797 0.3284228598467408 0.742591961023104 1.0 0.9039128247171664 5 Q9HCE1 1 +E2f mediated regulation of dna replication 0.3790458933266025 0.319603399623798 0.7492689969227062 1.0 0.9090443290266024 10 P49643,Q9Y619,P14635,P06493,Q9UBD5 5 +The phototransduction cascade 0.38295246172429 0.3150609825532295 0.7527153523653447 1.0 0.910875953848629 6 P49356 1 +E3 ubiquitin ligases ubiquitinate target proteins 0.3406415782728482 0.3082963744155433 0.7578568245802713 1.0 0.914744208282945 18 O75150,P61088,P78527,O75381,Q9BUN8,P04439 6 +Maturation of sars cov 1 spike protein 0.3470519556333976 0.3069147162304212 0.758908287394306 1.0 0.9152304218062955 4 P27824,Q13724,Q14697 3 +Cargo trafficking to the periciliary membrane 0.3312454756464081 0.2948775416110709 0.768087428719642 1.0 0.9245967706450952 20 Q9UPT5,A6NIH7,Q96KP1,O60645,P18085 5 +Post translational protein modification 0.2497874118637652 0.2947768986788672 0.768164314890704 1.0 0.9245967706450952 430 Q13546,P24390,P45880,P21796,Q13426,Q8NAT1,Q02818,Q16706,P16278,Q9BTE7,P09874,Q92564,O75381,P49721,P20337,O43731,O95487,Q92643,P41208,Q9Y5P6,P06493,Q92530,Q14789,P20618,P46977,Q9BTX1,Q15907,P10619,O60476,Q9NXR7,Q9Y3B3,P61088,P51665,O60725,P38435,Q9HA64,Q9BT78,Q8N4A0,Q99436,P62820,Q8NB78,P60900,Q9HCU5,O43292,Q86YN1,P04439,Q99627,Q9NX08,P28072,P04350,O43242,Q969Q5,P27824,Q9BUN8,Q96PC5,O75935,P05067,O60512,Q15363,O43505,Q07065,O95249,Q96MG7,P61289,Q9Y277,Q9Y6B6,Q9NXF7,Q13190,P49755,Q9UPU5,Q10472,P14735,P28074,Q96GG9,Q15388,Q70CQ2,Q9BTY2,Q9BT22,P15289,Q2TAA5,Q9BVK6,O43681,P61020,Q13409,O76024,Q16763,P18085,O14965,Q9UJW0,Q12907,P78527,Q9ULX3 92 +Apc c mediated degradation of cell cycle proteins 0.2909098913534426 0.29287833243583 0.7696151512195644 1.0 0.9245967706450952 58 P20618,Q9H1A4,Q9UJX4,P60900,P28072,P14635,P51665,P06493,P61289,P28074,P49721,Q92530,Q16763,Q99436,O14965 15 +Signaling by interleukins 0.2796606684970096 0.2801458665875403 0.7793655964925446 1.0 0.9303000018747976 115 P05067,Q13277,P78417,P60900,P28072,P09601,Q13126,P51812,P49721,Q15418,P14859 11 +Hedgehog on state 0.294070974289465 0.2721696579560497 0.785491570917606 1.0 0.9360883501391404 44 P20618,P60900,P28072,P51665,Q96J02,P61289,P28074,P49721,Q92530,P48729,Q99436 11 +Defective cftr causes cystic fibrosis 0.2933895325874497 0.2663721330254135 0.7899526247848678 1.0 0.9396557701319213 44 P60900,P28072,P61289,P49721,Q9BUN8 5 +Switching of origins to a post replicative state 0.2879493659777794 0.2644400847820694 0.791440827272587 1.0 0.9400025313818352 59 P20618,Q9H1A4,Q9UJX4,P60900,P28072,Q9Y619,P51665,O43242,P61289,P28074,P49721,Q92530,Q16763,Q99436,Q14566 15 +Glycogen breakdown glycogenolysis 0.3684194784393468 0.2617393044971594 0.7935224359479811 1.0 0.9408908883383204 7 P35573,P06737,P46976,P10253 4 +Negative regulation of notch4 signaling 0.2930232234863866 0.256874723213581 0.7972754839439653 1.0 0.943754788460516 40 P20618,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 9 +Regulation of mecp2 expression and activity 0.3452876969342288 0.2555463951480227 0.7983011146139907 1.0 0.944024834910344 14 Q14739,P42858 2 +Dna damage recognition in gg ner 0.3239587613129692 0.2537790390972628 0.7996662678035018 1.0 0.9440597242402424 20 P41208 1 +Tysnd1 cleaves peroxisomal proteins 0.3649189440946683 0.2469601442864317 0.8049390690793117 1.0 0.946939094212584 6 O00116 1 +Tp53 regulates transcription of cell death genes 0.363584625576674 0.2461359632009253 0.8055769846365117 1.0 0.946939094212584 8 Q07812,Q13315 2 +Pyruvate metabolism 0.3288793090249073 0.24541905735864 0.8061319744975348 1.0 0.946939094212584 18 P35613,O43708,P21796 3 +Dna double strand break repair 0.2857148557956656 0.2447155628017567 0.806676676997538 1.0 0.946939094212584 61 Q13535,Q9UQ84,Q13315,Q9UGN5,P28340,Q13426,P52292,Q9UNS1 8 +Rora activates gene expression 0.3304144775248173 0.241659006178538 0.809044396482494 1.0 0.948140899864451 4 Q15648,P50416,Q86X55 3 +Signaling by gpcr 0.2849679574206924 0.2386289993292305 0.8113932764286111 1.0 0.949316677479909 53 P05067,P42892,P07602,P51812,Q9NZJ7,Q15418,P52292 7 +Rnd3 gtpase cycle 0.3230028519908223 0.2306234861765805 0.817607320079385 1.0 0.9542133404731284 19 Q07065,O43396 2 +Role of phospholipids in phagocytosis 0.3600933605785024 0.2296542410288949 0.818360454881836 1.0 0.9543029767258434 6 Q8IV08 1 +Hdr through homologous recombination hrr 0.3037748759683929 0.227095455690955 0.8203495175795783 1.0 0.9558325097479644 27 Q9UQ84,P28340,Q13315,Q13535 4 +Sumoylation of dna damage response and repair proteins 0.2885902704779373 0.2239476197828978 0.8227980613707875 1.0 0.9571047523447496 43 P41208,Q13426 2 +Costimulation by the cd28 family 0.3363583138173301 0.2147322360396389 0.8299760880585925 1.0 0.960152374078624 14 P63000,P42345,Q14738,P30154,P41240,Q06124,P07947,Q16512,P62993,O00459,P60953,Q13177,Q16537 13 +Degradation of axin 0.2909636910595049 0.2077418250964686 0.835430558327314 1.0 0.9635664917258274 37 P20618,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 9 +Cross presentation of soluble exogenous antigens endosomes 0.2909636910595049 0.2077418250964686 0.835430558327314 1.0 0.9635664917258274 37 P20618,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 9 +Orc1 removal from chromatin 0.2837268953049914 0.2071856056048511 0.8358649084850551 1.0 0.9635664917258274 50 P20618,P60900,P28072,Q9Y619,P51665,O43242,P61289,P28074,P49721,Q92530,Q99436,Q14566 12 +Degradation of dvl 0.2888257726833271 0.2010390126425792 0.8406680690862864 1.0 0.9650438432578282 38 P20618,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 9 +Polymerase switching on the c strand of the telomere 0.3250442964529361 0.2002946766810756 0.841250125589744 1.0 0.9650438432578282 16 P49643,Q8WVB6,P49005,P35251,P0CG13,P40937,P28340,Q15554 8 +Tp53 regulates metabolic genes 0.2912894014221073 0.1939398707614632 0.8462229639944214 1.0 0.9665458334166352 35 P54646,Q15382,P42345,P14854,P32119,P13073,P00403 7 +Signaling by notch 0.2797766324469175 0.1890370255550625 0.8500637977258136 1.0 0.9696362316823952 63 P20618,P60900,P28072,P51665,Q96J02,Q9UBN7,Q15363,Q92542,Q9HCE1,P61289,P28074,P49721,Q92530,P16615,Q99436,P67809 16 +G1 s dna damage checkpoints 0.2842134452119549 0.1871524313034627 0.8515411200929199 1.0 0.9705367693466156 42 P60900,P28072,Q13315,P61289,P49721 5 +Regulation of ras by gaps 0.283719258291036 0.1828077023877893 0.8549489048266885 1.0 0.9728491167019818 40 P60900,P61289,P49721,P28072 4 +Metabolism of polyamines 0.2846791925757033 0.1794400515528052 0.8575921851184036 1.0 0.9736970887271752 39 P60900,P61289,P49721,P28072 4 +Advanced glycosylation endproduct receptor signaling 0.3447163585160495 0.1788506297608887 0.8580549893549667 1.0 0.9736970887271752 9 P05067,P09429 2 +Nucleotide biosynthesis 0.3383480136376171 0.17834197719482 0.8584544141577648 1.0 0.9736970887271752 12 P31939 1 +Cyclin a cdk2 associated events at s phase entry 0.2823943065445811 0.1748502607188837 0.8611972942661776 1.0 0.9752709318630668 44 P20618,P11802,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436 10 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.2794455386167994 0.17481580818733 0.8612243664786543 1.0 0.9752709318630668 51 P20618,Q9H1A4,Q9UJX4,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q16763,Q99436,O14965 13 +Transcriptional regulation by runx2 0.2769832813926117 0.1614264232116223 0.8717575568654015 1.0 0.9818286205702504 55 P20618,P11802,P60900,P28072,P14635,P51665,Q9UBN7,P06493,Q07812,P17931,P61289,P28074,P49721,Q92530 14 +Cellular senescence 0.2800479053542153 0.1597578782253676 0.8730718061230238 1.0 0.9818286205702504 46 Q9H1A4,P11802,P07305,P16402,Q13315,Q15554,Q9HCE1,P51812,P10412,Q16763,P16403,Q15418 12 +Initiation of nuclear envelope ne reformation 0.309115326957821 0.1595771740838149 0.8732141609757726 1.0 0.9818286205702504 19 O95067,Q86XL3,P14635,P06493,Q14739,P42167,Q8IXJ6 7 +Hdr through single strand annealing ssa 0.3112990795125396 0.1575873616290707 0.8747819630866087 1.0 0.9821316530796408 18 Q9UQ84,Q13535 2 +Visual phototransduction 0.3379381700339762 0.156816020356165 0.8753898466461385 1.0 0.9821316530796408 10 P49356,P49354 2 +Toll like receptor cascades 0.2888516927086312 0.1565044019646808 0.8756354497336556 1.0 0.9821316530796408 31 P05067,P09429,P50570,P51812,Q15418 5 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.2778524796991321 0.137385746966856 0.8907258964917064 1.0 0.9911713276379148 43 P20618,P60900,P28072,P51665,Q96J02,P61289,P28074,P49721,Q92530,Q03164,Q99436 11 +S phase 0.2744119645367297 0.1362104796779613 0.8916548907976793 1.0 0.9911713276379148 95 Q9Y619,P51665,P61289,Q99436,P60900,Q9Y248,Q14691,P49721,Q14566,Q9H1A4,Q9UJX4,P28072,O43242,P28074,Q92530,Q16763,Q29RF7,P20618,P11802,P35251,Q9NR33,Q9BRT9,P28340,Q07864 24 +Rhou gtpase cycle 0.3000618401246097 0.1345337782337544 0.8929805026961648 1.0 0.9911713276379148 21 Q9NNW5,O14964,O96013,Q8TAA9,O43396,Q93008,Q9UM54 7 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.3306536542855473 0.1334032573596453 0.8938744694346592 1.0 0.9911713276379148 11 Q9H1A4,Q9UJX4,Q9UJX3,Q16763,Q13042,P30260 6 +Apc cdc20 mediated degradation of nek2a 0.3306536542855473 0.1334032573596453 0.8938744694346592 1.0 0.9911713276379148 11 Q9H1A4,Q9UJX4,Q9UJX3,Q16763,Q13042,P30260 6 +Trans golgi network vesicle budding 0.2783934970125534 0.132063227064882 0.8949342816518098 1.0 0.9911713276379148 39 P55327,O75976,P05067,Q01968,P02786,Q9Y5X3,Q14789,Q99523,P15586,O00203,Q92572,P78537,P50570,O60749,O00443 15 +Signaling by notch4 0.276713224684969 0.1292463029283604 0.8971627589949849 1.0 0.99286011995445 44 P20618,P60900,P28072,P51665,P61289,P28074,P49721,Q92530,Q99436,Q92542 10 +Dna damage telomere stress induced senescence 0.3047826244726227 0.1271559820035304 0.898816943776888 1.0 0.9938411701241996 18 P07305,Q13315,P16402,P10412,P16403 5 +Peroxisomal protein import 0.2928084872146275 0.1209167121742318 0.903757004896875 1.0 0.9978099639354387 24 Q15067,P14735,O15228,O75381,A8MXV4,O00116,O15254 7 +Membrane trafficking 0.2593197818997045 0.1124180538838105 0.910491941134996 1.0 1.0 256 P54646,O95249,Q9Y3B3,P24390,Q12965,Q6NUQ1,Q01968,Q9Y5X3,Q9UIQ6,P15586,Q92572,Q96A65,Q9BT78,Q14108,O00461,Q9Y678,Q8TBA6,P62820,P55327,O75396,O60343,Q16706,P61026,Q9BVK6,Q9Y6B6,Q14204,Q9HCU5,Q13190,P43034,O43731,O95487,P49755,A2RRP1,O00443,P61020,Q99627,Q10472,Q4KMP7,Q9UPT5,Q10471,O15260,P04350,Q15042,Q13409,P18085,Q96PC5,O75935,Q14789,P05067,Q9UJW0,O15498,Q9P2W9,P02786,Q12907,Q99523,O00203,Q15907,Q15363,Q96KP1,Q6ZUT9,P50570,O60645,O60476,P54619 64 +Degradation of gli1 by the proteasome 0.272127820081572 0.0932306397385383 0.9257203333968718 1.0 1.0 42 P20618,P60900,P28072,P51665,Q96J02,P61289,P28074,P49721,Q92530,Q99436 10 +Tnfr2 non canonical nf kb pathway 0.271892487310736 0.0912793018207606 0.9272706640754932 1.0 1.0 43 P60900,P61289,P49721,P28072 4 +Apoptotic factor mediated response 0.3169188942326346 0.0893948846022484 0.9287680886926276 1.0 1.0 8 Q07812 1 +Activation of rac1 downstream of nmdars 0.2611613656259214 0.0803352484867457 0.935970624559546 1.0 1.0 3 Q14012,P63000 2 +Mapk3 erk1 activation 0.2775831873905493 0.0748835281615007 0.9403073823790016 1.0 1.0 4 P06493,Q02750,Q06124 3 +Auf1 hnrnp d0 binds and destabilizes mrna 0.2695094406385776 0.0736893401004829 0.9412575810952368 1.0 1.0 42 P60900,P61289,P49721,P28072 4 +Asymmetric localization of pcp proteins 0.2706030643049305 0.0683677202409014 0.9454929172026714 1.0 1.0 38 P60900,P61289,P49721,P28072 4 +Regulation of tp53 activity 0.2658248801352217 0.0669577963162514 0.9466153014212282 1.0 1.0 53 P54646,P42345,Q13535,P54619,Q9UQ84,P06493,Q13315,Q00535,Q8TBX8,O14965 10 +Hedgehog ligand biogenesis 0.2683083663016959 0.0648306170589161 0.9483088638327036 1.0 1.0 42 P60900,P61289,P49721,P28072 4 +Interleukin 12 signaling 0.2766347288640934 0.0640775984306013 0.9489084390444852 1.0 1.0 27 Q13126 1 +Transcriptional regulation by runx3 0.2671818490993543 0.056583439258463 0.9548770269644722 1.0 1.0 42 P60900,P61289,P49721,P28072 4 +Cellular response to hypoxia 0.2659300241318738 0.0502957265463696 0.9598867291836864 1.0 1.0 40 P60900,P61289,P49721,P28072 4 +Aggrephagy 0.2868633697373449 0.0444782347488105 0.9645232009585998 1.0 1.0 17 O95613,P04350,P61088,Q13409,Q9UBN7 5 +Mapk6 mapk4 signaling 0.2638441102005682 0.0417466854582817 0.9667006367648974 1.0 1.0 51 P20618,P60900,P28072,P51665,P06493,Q9HCE1,P61289,P28074,P49721,Q92530,Q99436 11 +Negative feedback regulation of mapk pathway 0.277664233576647 0.0387330806858931 0.9691031986171276 1.0 1.0 5 P36507,P28482,Q02750,P04049 4 +Intraflagellar transport 0.2937573302900584 0.0353231941605815 0.97182202860371 1.0 1.0 13 P04350,A0AVF1,Q92973,Q9Y496 4 +Cyclin a b1 b2 associated events during g2 m transition 0.2967037565468154 0.0349564760429507 0.9721144467304296 1.0 1.0 12 P14635,P06493,O95067 3 +Signaling by ntrks 0.2656243207684202 0.0248008856098896 0.9802137846622598 1.0 1.0 36 P50570,P51812,Q07812,Q15418 4 +Basigin interactions 0.2890594886461943 0.02368122259488 0.9811068840046429 1.0 1.0 7 P35613 1 +Neuronal system 0.2617749019200511 0.0189646368575877 0.9848693160327388 1.0 1.0 59 O95197,P51812,P52292,Q15418 4 +Platelet homeostasis 0.2922589370559317 0.0162644048662724 0.9870234545852083 1.0 1.0 11 P16615 1 +Negative regulators of ddx58 ifih1 signaling 0.2654014598540187 0.0144114171474277 0.9885017507700292 1.0 1.0 5 Q7Z434,Q96J02,P61086,Q14258 4 +Apoptotic execution phase 0.2656412371721119 0.0142094286637427 0.9886628977610012 1.0 1.0 31 Q16625,P09429,P16402,P49354,P10412,P16403,P42574 7 +Apoptotic cleavage of cell adhesion proteins 0.281841288443876 0.0089939146092945 0.9928239911373524 1.0 1.0 7 Q16625 1 +Ephrin signaling 0.2613138686131439 0.0071016846585241 0.9943337230840772 1.0 1.0 5 P63000,O00560,Q13177,Q16512 4 +Glycogen metabolism 0.2867591992488337 0.0025872907999604 0.9979356429195644 1.0 1.0 11 P06737,P46976,P35573,Q04446,P10253 5 +Raf independent mapk1 3 activation 0.2778264680105108 0.0013469783526322 0.9989252670936896 1.0 1.0 7 Q02750,Q06124,P06493,Q99956,P36507,P28482 6 +Regulation of runx2 expression and activity 0.2594329309618522 0.000191342737952 0.999847330584498 1.0 1.0 43 P60900,P61289,P49721,P28072 4 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8866fb0a231a208fbe21cf3c95206db2b4f43269 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine neurotransmitter release cycle", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of caspases through apoptosome mediated cleavage", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the phototransduction cascade", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pe", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Ampk inhibits chrebp transcriptional activation activity", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via dependence receptors in the absence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular hexose transport", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Clec7a inflammasome pathway", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of particulate exogenous antigens phagosomes", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Dectin 2 family", "Defective cftr causes cystic fibrosis", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective lfng causes scdo3", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr activation", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling by cbl mutants", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of cell death genes", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose catabolism", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 processing", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming and elongation in the cis golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Ncam1 interactions", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neurofascin interactions", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Norepinephrine neurotransmitter release cycle", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch2 intracellular domain regulates transcription", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Olfactory signaling pathway", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase 2 plateau phase", "Phase 3 rapid repolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Ptk6 regulates rtks and their effectors akt1 and dok1", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine catabolism", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Ras signaling downstream of nf1 loss of function variants", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of fzd by ubiquitination", "Regulation of gene expression by hypoxia inducible factor", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in bcr signaling", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of keratinocytes", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx1 regulates transcription of genes involved in interleukin signaling", "Runx1 regulates transcription of genes involved in wnt signaling", "Runx2 regulates bone development", "Runx2 regulates chondrocyte maturation", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates immune response and cell migration", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory perception of taste", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Serotonin neurotransmitter release cycle", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is proteolytically processed", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of immune response proteins", "Sumoylation of intracellular receptors", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 24 hydroxycholesterol", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis of wybutosine at g37 of trna phe", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADO", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP12", "AKAP13", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANO6", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "AP3S1", "APBB1", "APEH", "APEX1", "APIP", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARL8A", "ARMC8", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "AS3MT", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3B", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATR", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BARD1", "BAX", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCKDHB", "BCKDK", "BCR", "BCS1L", "BDH2", "BECN1", "BICD2", "BIRC6", "BLM", "BLMH", "BLOC1S1", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BSG", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "C2orf49", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC115", "CCDC22", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK9", "CDKAL1", "CENPF", "CENPU", "CEP250", "CEP290", "CEP97", "CERS1", "CERS2", "CETN2", "CFL1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHTF18", "CHTF8", "CHUK", "CIAPIN1", "CIT", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN7", "CLINT1", "CLIP1", "CLNS1A", "CLTA", "CLTB", "CLTC", "CMAS", "CMBL", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT4", "CNOT7", "COASY", "COG5", "COG7", "COG8", "COLGALT1", "COMMD2", "COMMD7", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTC", "CWC22", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF16", "DCAF7", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDA1", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DENND5B", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPH1", "DPH2", "DPH5", "DPM1", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DSC2", "DSE", "DSG2", "DSP", "DST", "DTL", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFHD2", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERCC2", "ERCC3", "ERCC6L", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESPL1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM49B", "FAM91A1", "FAM98B", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXL18", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP14", "FKBP4", "FKBP5", "FKBP8", "FKBP9", "FLAD1", "FLCN", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTA", "FNTB", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN6", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNE", "GNG5", "GNL3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GTSE1", "GUSB", "GYG1", "GYS1", "H1F0", "H2AFX", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HERC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILK", "IMMT", "IMP3", "IMP4", "IMPDH2", "INCENP", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS4", "INTS6", "INTS7", "INTS8", "INTS9", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRS4", "ISCA2", "ISG20L2", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JMJD6", "JUP", "KARS", "KAT7", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIN9", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPCAT4", "LRP1", "LRPPRC", "LRRC1", "LRRC41", "LRRC8A", "LRRFIP1", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MAGED1", "MAGED2", "MAGT1", "MAIP1", "MAN1A2", "MAN2A1", "MAN2B1", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MARC1", "MARC2", "MARCKS", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCRS1", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "METAP2", "MFAP1", "MFGE8", "MFN1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU2", "MID1", "MIF", "MIGA1", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOCS2", "MOCS3", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL50", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1C", "MYO1E", "MYO5A", "MYO6", "NAA35", "NADK2", "NAE1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCKAP1", "NCKIPSD", "NCL", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEK9", "NELFB", "NELFCD", "NELFE", "NET1", "NEU1", "NF1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NIT2", "NLN", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NOTCH2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUDC", "NUDT1", "NUDT16", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OTULIN", "OXA1L", "OXCT1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNT", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDK3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PEBP1", "PELP1", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PIK3R4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "POFUT1", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "PON2", "POP1", "POR", "POU2F1", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPFIBP1", "PPIB", "PPID", "PPIE", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R2", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PTBP1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUS1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "REL", "RELA", "REPS1", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RGS10", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP7A", "RRP8", "RRP9", "RSF1", "RSU1", "RTCB", "RTF1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SATB2", "SC5D", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFPQ", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3RF1", "SHMT1", "SHMT2", "SHPRH", "SHTN1", "SIGMAR1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLIT2", "SLK", "SLTM", "SLU7", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMYD3", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR3", "SSR4", "SSRP1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX18", "STX3", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SULT2A1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SYMPK", "SYNE2", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFG", "TFIP11", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TM7SF2", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM87A", "TMLHE", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TNRC6A", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPX2", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC13", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRMT10C", "TRMT11", "TRMT61A", "TRMU", "TRRAP", "TSFM", "TSG101", "TSN", "TSNAX", "TSPO", "TSR1", "TST", "TSTA3", "TTC26", "TTC37", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXNDC5", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBR1", "UBR2", "UBR4", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC119B", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS25", "VPS26A", "VPS28", "VPS29", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VPS72", "VRK1", "VRK2", "VRK3", "WAPL", "WARS", "WASF2", "WBP11", "WDCP", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR35", "WDR36", "WDR4", "WDR43", "WDR46", "WDR48", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR91", "WFS1", "WIPI2", "WLS", "WNK1", "WRAP53", "WTAP", "WWP2", "XAB2", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YES1", "YKT6", "YME1L1", "YPEL5", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCRB1", "ZFYVE16", "ZMYM2", "ZNF512B", "ZNF638", "ZW10"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCB7", "ABCB8", "ABCD4", "ABHD10", "ACADVL", "ACOX1", "ACOX3", "ACP6", "ADPGK", "AGL", "AGPAT5", "AGPS", "AGTPBP1", "AHCYL1", "ALDH1A2", "ALDH3A2", "ALG1", "ALG11", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANO6", "AP1B1", "AP1G1", "AP3B1", "AP3S1", "APOO", "APOOL", "APP", "ARF4", "ARFGAP2", "ARHGEF2", "ARSA", "ASAH1", "ASCC2", "ASCC3", "ASNA1", "ATAD3B", "ATG9A", "ATIC", "ATM", "ATP13A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATR", "AURKA", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BAX", "BICD2", "BLOC1S1", "BRD2", "BSG", "C19orf70", "CAMK1", "CAMK2G", "CANX", "CARM1", "CASK", "CASP3", "CCNB1", "CCNB2", "CDC16", "CDC27", "CDC37", "CDC42", "CDC6", "CDK1", "CDK4", "CDK5", "CDK5RAP2", "CERS1", "CERS2", "CETN2", "CHTF18", "CHTF8", "CKAP4", "CLCN7", "COASY", "COMMD8", "COMT", "COPG1", "COPS2", "COPS4", "COPS8", "COX15", "COX2", "COX4I1", "COX6B1", "CPD", "CPPED1", "CPT1A", "CPT2", "CRK", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CTSA", "CUL3", "CYB5B", "CYFIP1", "CYP51A1", "DCAF16", "DCTN1", "DCTN3", "DCTN4", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DDRGK1", "DENND5B", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHX36", "DNAJC13", "DNM2", "DOCK7", "DOLPP1", "DUSP9", "DYNC1H1", "DYNC1I2", "ECE1", "ECT2", "EEF1D", "EIF2B2", "EIF2S1", "EIF2S2", "EIF3A", "EIF3L", "EIF4B", "EIF5", "EIF5B", "EMD", "ENDOD1", "EPHX1", "ERAP1", "ERCC2", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC7", "FADS2", "FASN", "FDFT1", "FGFR1OP", "FLOT1", "FN3KRP", "FNTA", "FNTB", "FUCA2", "GAA", "GALNT1", "GALNT2", 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3.407766990291262 5.864077669902913 0.1350713234786387 0.1703873780123549 1.3379225542760151 0.7043353086258667 1.932540087143412 0.2532951180616937 0.0934764824591146 0.0573151884822011 0.1094892401774078 0.0328731354880699 0.113339965404402 +Pregnane x receptor pathway 1 5 2.1502434928795853 0.0315359595159416 1.1893203883495145 4.766990291262136 0.5016334176412254 0.4430864332327935 1.2160266844733736 0.6855496483071739 1.011470017110033 0.3166911340775686 1.0 1.0 1.0 0.290751966651369 0.1467539296032722 +Nrf2are regulation 0 8 2.1470811306184423 0.0317868232420306 1.3932038834951457 7.487864077669903 0.5584074795150484 0.4834256005216908 1.868427620745717 1.627240293200848 0.8067836575465853 0.2862393699405285 0.157867792113085 0.0981765691424607 0.1837383274168749 0.4028006685093745 0.6502314184365742 +Apoptosis modulation by hsp70 3 5 2.1154276278145123 0.0343935171491831 1.116504854368932 4.37378640776699 0.6980556798635181 0.4553264587927301 1.2564472247640217 1.5830081456928182 0.8995929017617261 0.3096983934223993 1.0 1.0 1.0 1.0 0.5507460232908605 +Nonalcoholic fatty liver disease 18 55 2.083329735568417 0.0372211780938724 14.446601941747574 49.78883495145631 0.8140299356769594 0.4039994838731682 5.918094936421778 5.382150615191258 1.5259550974793896 0.3817978315095583 0.083180778464552 0.1267011687502946 0.033005107755267 0.0009538334978556 0.0001252927918642 +Mitochondrial complex iv assembly 5 12 2.076013380557694 0.0378927134736628 4.645631067961165 11.985436893203884 1.036764412652062 0.2236438909453165 2.399566170297607 1.9080263664188637 1.5325215618909758 0.2795558816325345 0.2429761091428759 0.1541506060207377 0.0420348553288257 0.0088087297166582 0.0054583584483833 +Alzheimers disease and mirna effects 29 92 2.0642262121036783 0.0389962733454896 19.78640776699029 84.62864077669903 0.8675405351918691 0.5019659822826982 9.06411947478317 6.212690980603589 1.0744065053186531 0.3869842050583563 0.0788753857556171 0.0736360802948869 0.1246977476538018 0.0229801348291327 0.0006937188076055 +Degradation pathway of sphingolipids including diseases 4 8 2.0559699227874675 0.0397854154151942 3.645631067961165 6.432038834951456 0.0687547082162972 0.1728701573933007 1.3368036576958324 0.5554170290527195 1.9109030412897592 0.2451148181788838 0.0709501192712976 0.0432957136582515 0.0832836732680532 0.0188064524051028 2.8870402872731e-05 +Lung fibrosis 0 6 2.015185992075529 0.0438851647009743 1.199029126213592 5.728155339805825 0.180000282984538 0.4698716201887856 1.2204563165107083 0.5249905178483796 0.9537706627653704 0.255471846967142 0.1509425000049774 0.0937235599037543 0.1758008751515455 0.3879443652654283 0.6322714034398937 +Alzheimers disease 16 90 2.007238639833155 0.0447242591485215 18.929611650485437 83.0752427184466 0.8523996335219438 0.5089902911900335 9.09856474570077 6.061710858604258 1.0800674607776464 0.3865214102951685 0.0755271999699754 0.071048600593009 0.1197766464902761 0.0209324672006932 0.0013981409421044 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b14561636d4f8de1da7646c64e6a6f7f38cde2bc --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 607, + "title": "Average number of proteins per term", + "value": 11.841845140032948 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bfe0e99597d87ce08262730eae2492419bb67d70 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..19c23e6e21987479dbe0b67dda5446e3f117629d --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,172 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Overview of nanoparticle effects 0.8929404900816693 3.4316797082344808 0.0005998555510988 0.305262755664945 0.0110337066520307 2 P09601 1 +Drug induction of bile acid pathway 0.8722287047841223 3.33492033679725 0.0008532383892636 0.4043706973402975 0.013974006282691 2 Q06520 1 +Proteoglycan biosynthesis 0.9177070458978172 3.3215495276977163 0.0008951909306944 0.4193599532499688 0.013974006282691 3 Q8TB61 1 +Metabolism of spingolipids in er and golgi apparatus 0.9060402684563658 3.269080119651105 0.001078977446965 0.4807100581789541 0.0144531177900463 3 O95470,Q06136 2 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.9536819451808 3.265802286765394 0.0010915443265451 0.4846604526961029 0.0144531177900463 4 P09601 1 +Liver x receptor pathway 0.8547257876312712 3.2522204838114535 0.0011450715913847 0.5011534302002965 0.0147884777866076 2 P49327 1 +Nanoparticle triggered regulated necrosis 0.8389731621936986 3.17704480073758 0.0014878405038234 0.5949690121610505 0.0180623837164166 2 Q13546 1 +Vitamin d metabolism 0.8748176247446633 3.1269327207416455 0.0017664034522408 0.6580719646895611 0.0191465517055395 3 P38435,P04062 2 +Glycerophospholipid biosynthetic pathway 0.8642732049036773 2.8711724338909113 0.0040895237931126 0.9168767322706304 0.0370498648122297 4 O15228,O00116,P48651 3 +Peroxiredoxin 2 induced ovarian failure 0.8426736719205957 2.772847400595558 0.0055568171756161 0.9660339718902804 0.0468470559110975 4 Q07812,P32119,Q9UGN5 3 +Pi3kaktmtor signaling pathway and therapeutic opportunities 0.835136917740521 2.7382547271914426 0.0061766214195939 0.9767357126230816 0.0474583443252346 4 Q15382 1 +Nonhomologous end joining 0.8227822695746749 2.681227172258205 0.0073352700884719 0.9885403077344554 0.0536446860687041 4 Q13426 1 +Oxidation by cytochrome p450 0.8815256429768279 2.6546604009429924 0.0079388286312291 0.9920778996269756 0.0552252791346448 6 Q16850,O43169,Q6UW02 3 +Sphingolipid pathway 0.8624757316758889 2.651803980588152 0.0080063007641659 0.992398302030384 0.0552252791346448 8 O95470,P04062,Q96G23,Q06136 4 +Insulin signaling in adipocytes normal condition 0.7721038809454323 2.6405804824737595 0.0082764132248136 0.9935565276772054 0.0558198091940209 3 P42345,O60343 2 +Insulin signaling in adipocytes diabetic condition 0.7721038809454323 2.6405804824737595 0.0082764132248136 0.9935565276772054 0.0558198091940209 3 P42345,O60343 2 +Sphingolipid metabolism overview 0.8662958067683374 2.627317611700716 0.0086060963984806 0.994734130590428 0.0561304486155953 7 Q13510,O95470,Q96G23,Q06136 4 +Sphingolipid metabolism integrated pathway 0.8662958067683374 2.627317611700716 0.0086060963984806 0.994734130590428 0.0561304486155953 7 Q13510,O95470,Q96G23,Q06136 4 +Exrna mechanism of action and biogenesis 0.7243290548424738 2.6074040995670646 0.0091231622140273 0.9961634244787826 0.0582922048833113 2 Q9HAV4 1 +Electron transport chain oxphos system in mitochondria 0.5311900526872869 2.5969611784551474 0.0094052553400842 0.9967723687794064 0.0585869722932232 52 P14406,P14854,O43676,P21912,O75964,P13073,P24539,P12235,P47985,P56385,P03886,O14949,Q9Y6M9,P00403,P12236,Q9UDW1,P22695,P51970,Q7KZN9 19 +Iron metabolism in placenta 0.721995332555429 2.5953780207842794 0.0094486934693236 0.9968571481207564 0.0585869722932232 2 P02786 1 +Statin inhibition of cholesterol production 0.8343286290373506 2.5880573843464414 0.0096518899988835 0.9972251379291992 0.0585869722932232 5 P37268,Q8WTV0 2 +Cholesterol biosynthesis with skeletal dysplasias 0.851587020389604 2.523231624660931 0.0116281781237221 0.9991746166878992 0.0672219440104701 6 Q16850,Q15392,Q14739,Q9UBM7 4 +Hostpathogen interaction of human coronaviruses apoptosis 0.7841717075351297 2.500396071104177 0.0124054526172479 0.9994880107151756 0.0699032321676836 4 Q07812,Q07820 2 +Sphingolipid metabolism in senescence 0.7631664246904387 2.490625595332524 0.0127518417215195 0.9995862065015428 0.0710125497702969 13 Q13510,P42345,P04062,P16278,Q06136,Q96G23 6 +Metapathway biotransformation phase i and ii 0.6235141433292796 2.440627205856488 0.0146617812873448 0.9998722696031904 0.0787584180656489 25 P78417,Q86UY6,Q06520,Q16850,P07099,Q6UW02,O15217 7 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.6106561045456999 2.3554765979682584 0.0184989622094762 0.9999880410451956 0.0959732483859151 25 P49327,Q15392,O76062,Q15800,Q14534,Q16850,O95864,Q9UBM7,P48449,Q14739,P37268,O75845 12 +Ferroptosis 0.6170669120950757 2.292470848916336 0.0218784878210549 0.9999985262085318 0.1071744408821804 23 Q9Y277,P45880,P09601,P16435,P37268,Q9NZ45 6 +Triacylglyceride synthesis 0.7656061176033093 2.270555630974663 0.0231738919885224 0.9999993407107411 0.1090430421475438 5 Q9NUQ2,O00116 2 +Regulation of apoptosis by parathyroid hormonerelated protein 0.7589393847439652 2.239117145653259 0.0251482949483152 0.999999806935128 0.114465469004764 5 Q07812,Q9BXK5 2 +Nad biosynthetic pathways 0.7574840604481367 2.2322392071211894 0.0255991574091496 0.999999854201164 0.114465469004764 5 P09874,Q9UGN5,P43490 3 +Mitochondrial complex iii assembly 0.7542432975652158 2.228993551860539 0.0258143338214966 0.9999998724932184 0.114465469004764 10 O14949,P22695,Q9UDW1,P47985 4 +Hostpathogen interaction of human coronaviruses mapk signaling 0.770043114888728 2.2254129213505616 0.0260535309024083 0.9999998901504992 0.1145977772301585 8 P51812 1 +Nad metabolism 0.7219589105034552 2.2005520072533753 0.027767754335213 0.9999999622946668 0.1178673208494708 4 P09874,P43490 2 +Mirna biogenesis 0.6800746874644157 2.178794867652538 0.0293469104024499 0.9999999859436348 0.121180779689028 3 Q9HAV4 1 +Glycosaminoglycan degradation 0.773409552974643 2.17005871471893 0.0300023982551271 0.9999999906719488 0.1212553909517255 6 P16278 1 +Pregnane x receptor pathway 0.7402210831781934 2.1502434928795853 0.0315359595159416 0.9999999964298673 0.1244813013413715 5 Q06520 1 +Apoptosis modulation by hsp70 0.7329387112972634 2.1154276278145123 0.0343935171491831 0.9999999994061116 0.1321363016026117 5 P49327,Q13546,P42574 3 +Nonalcoholic fatty liver disease 0.4696170655071219 2.083329735568417 0.0372211780938724 0.9999999998998612 0.1350688675594876 55 P54646,P47985,P49327,P14406,P14854,P22695,P51970,Q9UDW1,Q07812,P13073,O14949,Q9Y6M9,Q9P0J0,P00403,O43676,Q86Y39,P42574,P21912 18 +Mitochondrial complex iv assembly 0.6996455699262565 2.076013380557694 0.0378927134736628 0.9999999999344358 0.1352992769324315 12 P14406,Q9Y2R0,P13073,P00403,Q7KZN9 5 +Alzheimers disease and mirna effects 0.4338488406486442 2.0642262121036783 0.0389962733454896 0.9999999999673322 0.1376205693064662 92 Q96IX5,P51665,P45880,P21796,Q99436,P42574,Q9Y277,Q8NE86,P60900,O95197,P0DP25,Q96GC9,P49721,P12235,Q92542,P28072,P04350,P14735,Q00535,P28074,P48729,P12236,P20618,P05067,P42345,P49327,P05141,P16615,Q9NQC3 29 +Degradation pathway of sphingolipids including diseases 0.7345490768362595 2.0559699227874675 0.0397854154151942 0.9999999999801592 0.1387916503277177 8 P17900,P15289,P06280,P16278 4 +Ethanol metabolism production of ros by cyp2e1 0.6158109684947576 2.029162988060603 0.0424416920225987 0.9999999999963076 0.1455486274447312 2 P36507 1 +Pkcgamma calcium signaling pathway in ataxia 0.6126021003500675 2.011473453406425 0.0442754715857311 0.9999999999988466 0.1493067291807713 2 P23634 1 +Alzheimers disease 0.4302373078320873 2.007238639833155 0.0447242591485215 0.9999999999991328 0.1499868801279147 90 P05067,P16615,Q9Y277,P60900,P28072,O95197,P14735,P45880,P0DP25,P21796,P28074,P49721,P48729,P12236,P12235,Q9NQC3 16 +Serotonin and anxiety 0.6047257876312816 1.967913580216484 0.0490779819982805 0.9999999999999458 0.1597367910478189 2 Q06787 1 +Tp53 network 0.6279486661512528 1.9060466119633297 0.0566441584051737 0.9999999999999996 0.1763230982150794 3 Q13315 1 +Erk pathway in huntingtons disease 0.6877433418269612 1.8964082244863572 0.0579060851816228 0.9999999999999998 0.1793316005369647 5 P42858,P42574 2 +Bdnftrkb signaling 0.6919822686169861 1.84866816590164 0.0645057431232409 1.0 0.1987562744964836 8 Q15382,Q15418 2 +Inclusion body myositis 0.6150177775275083 1.8371798615537216 0.066183347601104 1.0 0.2018758391651765 3 P05067 1 +Reninangiotensinaldosterone system raas 0.6443380723186868 1.811858829211566 0.0700080123146262 1.0 0.2072920169511129 4 P0DP25 1 +Vitamin a and carotenoid metabolism 0.6695629637648745 1.806917557514714 0.0707751345440683 1.0 0.2085461488749975 5 Q6NUM9,Q8WTV0 2 +Caloric restriction and aging 0.6375612718233704 1.7771918657259702 0.0755366773389365 1.0 0.2193816418408348 4 P43490 1 +Ovarian infertility 0.6307495230214499 1.7422358487112513 0.0814671835077605 1.0 0.2321623492451203 4 Q13315 1 +Hostpathogen interaction of human coronaviruses autophagy 0.6499779537475561 1.7096742426636344 0.0873261283099235 1.0 0.2442717045351319 5 P42345 1 +Angiopoietinlike protein 8 regulatory pathway 0.488773165830401 1.6932313762246436 0.0904114344722775 1.0 0.2505924234003308 30 P54646,O75955,Q15382,P49327,P42345,P11166,Q9UPT5,O14654,P46108,P51812,O00767,Q15418,P54619,O00443 14 +Omega9 fatty acid synthesis 0.6670449537645186 1.6667361716600184 0.0955668770308162 1.0 0.2587561168307168 6 P49327,O95864 2 +Ltf danger signal response pathway 0.548716452742137 1.6526940443145468 0.0983931471147219 1.0 0.2642683199054699 2 P28482 1 +Endothelin pathways 0.6374197382891168 1.6402475179712783 0.1009537129139785 1.0 0.2688645860285295 10 P42892,P00403 2 +Synaptic signaling pathways associated with autism spectrum disorder 0.6336016612170927 1.6204469259678007 0.1051363065299963 1.0 0.2750764571711543 10 P54646,P42345,Q15382 3 +Allograft rejection 0.6239541908656455 1.5702794046650737 0.1163501234190609 1.0 0.2967417013250839 10 P49327,P42574,P01889,P08183 4 +Male infertility 0.5013237211304126 1.5547291953250542 0.1200105783109253 1.0 0.3013118554493164 24 P49327,Q15165,P50750,Q13315,Q13426,P08183 6 +Disorders of folate metabolism and transport 0.6314927062674787 1.5470169334220218 0.1218591624505416 1.0 0.3019122922754235 8 P31939,P00374 2 +15q112 copy number variation syndrome 0.5909685078996723 1.5360449030839955 0.1245273678279461 1.0 0.3060247460387179 4 Q7L576 1 +Thermogenesis 0.4775327131681617 1.517283472461855 0.1291951291947586 1.0 0.3119268719693251 27 P54646,Q15382,P51812,O43772,Q15418,P23786 6 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.5428612510656109 1.483312976605806 0.1379912762094028 1.0 0.3284733516043433 16 P11802,O60725,O75844,P55209,P49354,P48729,P42167 7 +Base excision repair 0.5337804824053363 1.4709969516884074 0.1412919412539572 1.0 0.3306292895722026 17 P09429,P09874,Q9UGN5,Q9NR33,P28340,Q07864 6 +Influence of laminopathies on wnt signaling 0.6096229598947365 1.464692752984083 0.1430047630376902 1.0 0.3325819584822912 9 O75844,P49354,O60725 3 +Mirna regulation of p53 pathway in prostate cancer 0.5979037576260502 1.4473821354967074 0.1477899263430289 1.0 0.341096902244177 5 Q07812,Q13315 2 +1q211 copy number variation syndrome 0.6038044926013517 1.434648562370156 0.1513872687804498 1.0 0.3454589178561393 9 P54646,Q9NPH0 2 +Autophagy 0.5938096472049927 1.412393360120998 0.1578341704590278 1.0 0.3561536857569884 10 P54646,P42345,Q7Z3C6,P54619 4 +Omega3 omega6 fatty acid synthesis 0.6112890800350719 1.3938802666933057 0.1633537641889866 1.0 0.3618822440245068 6 Q15067,O95864 2 +Nucleotide metabolism 0.5816306035676377 1.3789849467570403 0.1678993951868572 1.0 0.3658209492579372 11 P00374 1 +Sars coronavirus and innate immunity 0.5008751458576564 1.37702693222067 0.1685039212917944 1.0 0.3658209492579372 2 Q7Z434 1 +Copper homeostasis 0.5835475399458009 1.3742941232781365 0.1693503900189132 1.0 0.3658209492579372 5 P05067,P42574 2 +Intracellular trafficking proteins involved in cmt neuropathy 0.566641779306516 1.3611496131746972 0.1734664136105963 1.0 0.3728176333421885 12 Q15907,P50570,Q9NR77,Q8TB36 4 +Mitochondrial long chain fatty acid betaoxidation 0.5534798177640531 1.3547463676484237 0.1754983793971587 1.0 0.3750968883594202 13 P49748,O43772,P23786 3 +Robo4 and vegf signaling pathways crosstalk 0.4962077012835649 1.3499057088194475 0.1770462302664124 1.0 0.3770774097253064 2 O94813 1 +Cytoplasmic ribosomal proteins 0.3774919025481087 1.3353587559554 0.181758956766483 1.0 0.3844170270287637 74 P46781,P46778,P62753,P26373,P62910,P51812,P46779,P46776,P84098,P62841,Q9Y3U8,Q07020,P83731,P27635,P42766,P62917,P61353,P62266,P47914,P62424,P61513,P62701,Q15418,P61927,P83881,P62277,P36578,Q02878,P62847,P39023,P62269,P62750 32 +Constitutive androstane receptor pathway 0.5918766628066123 1.320843090451182 0.1865536885405068 1.0 0.3878016744660535 7 Q06520 1 +Aryl hydrocarbon receptor pathway wp2873 0.5703767778329014 1.3070319799315828 0.1912018505558195 1.0 0.3960436863848986 5 Q07812,Q15185 2 +Serine metabolism 0.5884932984285584 1.2811246527479752 0.2001498859611969 1.0 0.4063243504295872 6 P00374 1 +Biomarkers for urea cycle disorders 0.4816219369895182 1.264990382118957 0.2058747756342389 1.0 0.4125110241876153 2 Q14353 1 +Nad metabolism sirtuins and aging 0.535184552545876 1.2423947194011036 0.2140909629935432 1.0 0.4233003730849535 4 P43490 1 +Cholesterol biosynthesis pathway 0.5332264075654066 1.2393619572612475 0.2152114832930074 1.0 0.4241343193469335 13 Q15800,Q9UBM7,Q16850,Q14534,P48449,P37268 6 +Nephrotic syndrome 0.5201809167564428 1.2318822148699289 0.2179930859508783 1.0 0.4282259002336024 14 Q14108 1 +Hematopoietic stem cell gene regulation by gabp alphabeta complex 0.5772330579111851 1.2252800893911209 0.2204697075877302 1.0 0.4303058279927724 6 Q07820,Q15554,Q13315 3 +Progeriaassociated lipodystrophy 0.5540216425589117 1.2020557759415471 0.2293419189617522 1.0 0.4413282974029332 10 O75844,P28340,O60725 3 +Adipogenesis 0.4970263394834336 1.200996760491137 0.2297524579560574 1.0 0.4413282974029332 16 O75844,P49327,P43490,Q9NZ45 4 +Ethanol effects on histone modifications 0.53029130423174 1.159747280448421 0.2461517141247649 1.0 0.4640189145146965 12 P04818,Q9UBN7,O14929,Q9H9T3,P00374 5 +Dna repair pathways full network 0.374313500707177 1.1452852886433866 0.2520909980110157 1.0 0.470828417823651 56 P41208,P09429,Q13535,Q9UQ84,Q13315,Q9UGN5,P28340,Q13426,O15360,Q07864 10 +Type i interferon induction and signaling during sarscov2 infection 0.4840968777356442 1.1196947884913726 0.2628438466274816 1.0 0.4787200642094504 3 P42224,Q7Z434 2 +Kennedy pathway from sphingolipids 0.5117104725962005 1.1181070786584066 0.2635212635519459 1.0 0.4787200642094504 4 O95470 1 +Familial partial lipodystrophy fpld 0.5473071382891477 1.096191646585911 0.2729949144861934 1.0 0.4902600979086372 7 O75844,O60725 2 +Ccl18 signaling pathway 0.5245131522407701 1.0711001531942044 0.2841243993502311 1.0 0.5057580950310566 11 Q96GC9,P00403,Q86UE4 3 +Acquired partial lipodystrophy barraquersimons syndrome 0.510499383842783 1.0004851325730866 0.317075789051201 1.0 0.5514756560288797 5 O60725 1 +Ketogenesis and ketolysis 0.5223927763875044 0.9708009790387522 0.3316473949779843 1.0 0.5702904037157145 7 O43772,P53985,P23786 3 +Mitochondrial complex i assembly model oxphos system 0.4026005582153767 0.9465593326638204 0.3438633748886688 1.0 0.5829218582123069 27 Q9P032,Q96CU9,P03886,P51970,Q9Y6M9,Q9NPL8,Q9P0J0,O43676 8 +Microglia pathogen phagocytosis pathway 0.4966423357664273 0.9299203470129022 0.3524123272357258 1.0 0.592560339701068 5 P16885,O00443,O15143,O00459 4 +Type ii interferon signaling ifng 0.5083208172744296 0.9003519741913013 0.3679329700807257 1.0 0.6146269870846988 7 Q03518 1 +Tryptophan metabolism 0.452450036768569 0.8941357549144735 0.3712492609351789 1.0 0.6173926065415167 15 Q15392 1 +Onecarbon metabolism 0.4621864264482075 0.8906977615534929 0.3730913359981249 1.0 0.6187607676253055 14 P00374 1 +Vitamin d receptor pathway 0.4680381272965609 0.867455997708638 0.385692211286033 1.0 0.6344584613837996 13 P20020,Q06520,Q96KA5 3 +Joubert syndrome 0.3988269492372335 0.8482724093617402 0.3962862795015285 1.0 0.644487546056396 25 Q15154,P41208,Q15382,P42345,Q13315,Q13432 6 +Sterol regulatory elementbinding proteins srebp signaling 0.3800746510279885 0.846815866311621 0.3970977631385373 1.0 0.644487546056396 31 P54646,P49327,P42345,Q8WTV0,Q9Y6B6,Q14534,Q16850,P48449,Q9NR31,P37268 10 +Phosphoinositides metabolism 0.4895967028001677 0.8414064996171599 0.4001202455256738 1.0 0.6459388006225639 9 Q01968,O00443,Q9NTJ5,Q8TBX8 4 +Neuroinflammation 0.4550671196867533 0.8205741570437289 0.4118888729621301 1.0 0.6623017679007057 4 P00403 1 +Srebf and mir33 in cholesterol and lipid homeostasis 0.473891505023105 0.8150525513215435 0.4150422299480607 1.0 0.662975351522297 5 P49327,P42345 2 +Folate metabolism 0.4438571400926503 0.7839922193221275 0.4330446758028885 1.0 0.6804503984958171 14 P00374 1 +Nitric oxide metabolism in cystic fibrosis 0.4471687098657385 0.7798009962354105 0.4355080198799617 1.0 0.6813231135750948 4 O60678,Q86X55,O14744 3 +Kit receptor signaling pathway 0.4120026009203653 0.7687065617709916 0.4420675286596651 1.0 0.6867594266748318 19 P51812 1 +Dna damage response 0.3775518792685652 0.75540505765849 0.4500059794994737 1.0 0.6915281760915963 27 P49327,O95067,Q13535,Q13315,P14635,P06493,Q00535,P78527,Q07812,P42574 10 +Camkk2 pathway 0.4453006676485889 0.7396062748870493 0.4595389330899384 1.0 0.6958359158557343 13 P09601,P42345 2 +Breast cancer pathway 0.3793560439608778 0.7363188952685397 0.4615366496986648 1.0 0.6958359158557343 26 P42345,Q13535,P09874,Q13315,Q07812,P48729 6 +Vasopressinregulated water reabsorption 0.4206075216060754 0.7297994634073376 0.4655127725325463 1.0 0.6958359158557343 16 P61020,Q15907,Q13409 3 +Mirna regulation of dna damage response 0.3694712204057776 0.7280786654588952 0.4665654328719668 1.0 0.6958359158557343 28 P49327,O95067,Q13535,Q13315,P14635,P06493,Q00535,P78527,Q07812,P42574 10 +Translation factors 0.3525426326178623 0.7130390953517904 0.4758215653349409 1.0 0.7027340393146208 37 P55010,P23588,P49770,O60841,Q9H074,P29692,O75153 7 +Amyotrophic lateral sclerosis als 0.4560388733742353 0.6874701735661464 0.4917864900278028 1.0 0.7193118058960876 10 Q07812,Q9BUN8 2 +Leptininsulin signaling overlap 0.3795215869311604 0.6776143682051595 0.4980162335767248 1.0 0.7231958224427559 2 O14654 1 +Target of rapamycin tor signaling 0.4514108580193964 0.6639094588664731 0.5067482619203985 1.0 0.7337903147054724 10 P54646,P42345,Q15382 3 +Network map of sarscov2 signaling pathway 0.3581013557951524 0.6596965090503761 0.5094486073674553 1.0 0.7337903147054724 30 Q15382,P42345,O95067,P14635,Q9UGN5,P06493,Q08380,P42574 8 +Histone modifications 0.428130410262015 0.6011055965189023 0.5477696560632004 1.0 0.7732469330938666 12 Q9H7B4,O15047,Q8IYR2,Q03164,Q01105 5 +Vitamin b12 disorders 0.403677758318745 0.5618280657587759 0.5742331681580164 1.0 0.7939852689565284 4 Q99707,P22033,Q9Y4U1 3 +Oxidative phosphorylation 0.3437650379340223 0.5482000751051969 0.5835545305505851 1.0 0.8050400001004663 30 O75964,P56385,P03886,Q15904,P51970,Q9Y6M9,P24539,Q86Y39 8 +Cancer immunotherapy by pd1 blockade 0.3729209220892998 0.5228914907005936 0.6010497665170691 1.0 0.8180206463584326 3 P40763,P04439 2 +Factors and pathways affecting insulinlike growth factor igf1akt signaling 0.428015792212054 0.5129995579495662 0.6079516299110745 1.0 0.8218856110379115 7 P42345 1 +Homologous recombination 0.4216911481812624 0.4933616434191222 0.62175707935166 1.0 0.832584200489981 8 P28340 1 +Nanomaterial induced apoptosis 0.4219988589811103 0.4857150121411269 0.6271692384260017 1.0 0.8334880544762193 7 Q07812,P49327,O95831,P42574 4 +Insulin signaling 0.3130533608795304 0.4794220728199621 0.6316383938370032 1.0 0.8334880544762193 50 P54646,O75955,Q15382,O60343,Q12965,P42345,P11166,O14654,Q96BR1,P46108,P46976,P51812,P04049,Q15418,O00443 15 +Gastric cancer network 2 0.3701324183146178 0.4772846486343215 0.6331594409444907 1.0 0.8336828213737655 18 Q658Y4,Q14739,P0CG13,Q86UE4 4 +Nrf2 pathway 0.3539754651978052 0.4451008929943013 0.6562468435137376 1.0 0.8439445635865227 21 P09601 1 +Pilocytic astrocytoma 0.3730297723292532 0.4184419745989698 0.6756240027558613 1.0 0.8561665337636906 4 P21359,P62993,P04049 3 +Regucalcin in proximal tubule epithelial kidney cells 0.4045181036158103 0.4156938161622632 0.6776340668329452 1.0 0.8569055675779007 8 Q07812,P42345,Q8NE86 3 +Proteasome degradation 0.3111809371803388 0.4137863161621084 0.6790306062684848 1.0 0.8569055675779007 42 P20618,P01889,P60900,P28072,P51665,P46934,P61289,P28074,P49721,P04439,Q99436 11 +Interactions between loxl4 and oxidative stress pathway 0.3433250706315334 0.3814060922455869 0.7029019411089577 1.0 0.8707377107206884 3 Q16543 1 +Photodynamic therapyinduced ap1 survival signaling 0.396448506301245 0.3741633932863659 0.7082827571277464 1.0 0.8739912535459151 7 Q07812,P49327 2 +Nipbl role in dna damage cornelia de lange syndrome 0.3971206070325732 0.3719952062050645 0.7098964185443108 1.0 0.8739912535459151 6 Q13535 1 +Integrated cancer pathway 0.3412289966654251 0.3660601669015987 0.7143201798713081 1.0 0.8759441397613819 21 Q13535,P42574,Q13315,P06493,Q07812,P14859 6 +Spinal cord injury 0.337097244494097 0.3287251833766291 0.7423634176668841 1.0 0.9012291890475972 20 P17931,P06493,P42574,Q9NQC3 4 +Nuclear receptors metapathway 0.2962317223362763 0.3206792270303922 0.7484534909884342 1.0 0.9037822881019514 50 P49327,Q15067,P11166,Q15043,P06493,Q06520,Q07812,P09601,O00767,O15217,P08183,P23786 12 +Follicle stimulating hormone fsh signaling pathway 0.3798877480771689 0.3106525142123526 0.7560648003731596 1.0 0.9087749184683324 8 P42345,Q15382,P62753 3 +Mthfr deficiency 0.3712577528518158 0.2759517468776842 0.7825851280721727 1.0 0.9205991719763738 8 Q7L592,P21964,P42574 3 +Dna mismatch repair 0.3268963996947686 0.2514290486839347 0.8014824112713061 1.0 0.9337808515195448 19 Q9UQ84,P28340 2 +Circadian rhythm genes 0.2874536685852905 0.2164675777987061 0.8286232951980179 1.0 0.9472209796331392 44 P54646,P49327,P04818,P43490,Q03164,Q9UNS1,P54802,Q9Y5V3 8 +Cellular proteostasis 0.3207322068144217 0.2062482402732227 0.8365970074995066 1.0 0.9489195586691236 4 O15212 1 +Ncrnas involved in wnt signaling in hepatocellular carcinoma 0.3513121632863258 0.2062405548646342 0.8366030105263396 1.0 0.9489195586691236 10 Q86UE4 1 +Selenium micronutrient network 0.3387100669813057 0.2005476938750844 0.8410522612256812 1.0 0.9489195586691236 13 Q8WTV0 1 +Egfegfr signaling pathway 0.281489235249198 0.1874033444342343 0.851344400578826 1.0 0.953442898803224 50 P00403,P51812,Q9P0J0 3 +Chromosomal and microsatellite instability in colorectal cancer 0.3188681961957363 0.1820592619863281 0.8555362185997839 1.0 0.9546148615626264 17 Q04864,Q07812,Q96KP1,P48729,P04049,P42574 6 +Glycosylation and related congenital defects 0.3419250830082359 0.168951125591842 0.8658350847666711 1.0 0.9643337549603108 9 Q9BT22,Q2TAA5 2 +7oxoc and 7betahc pathways 0.338092104775307 0.1573634403184721 0.8749584248284072 1.0 0.9709319266377388 10 O15118 1 +Extracellular vesiclemediated signaling in recipient cells 0.3205004823257766 0.15196220403896 0.8792167461838756 1.0 0.9721631154786908 5 P42345 1 +Head and neck squamous cell carcinoma 0.3150602426727962 0.1248444147783395 0.9006467245255583 1.0 0.9855731571353156 14 P54646,Q04864,P42345,Q15382,P11802 5 +G1 to s cell cycle control 0.2932865331033 0.1145040035235642 0.908838272921336 1.0 0.9868780530648495 23 P49736,P25205,P11802,P49643,Q9Y619,P14635,P06493,Q13315,P33991,P33993,P49642,Q9UBD5,Q07864,Q14566 14 +Il5 signaling pathway 0.3164561047844763 0.1122251664064439 0.9106448753059846 1.0 0.9870739987691656 13 Q15418,P62753 2 +P53 transcriptional gene network 0.3216049213536668 0.1019527847889701 0.9187941520005908 1.0 0.991541891822576 9 Q07812,P49327 2 +Atr signaling 0.3024700791086805 0.0990244709140504 0.9211188406122002 1.0 0.991541891822576 5 Q13535 1 +Mitochondrial immune response to sarscov2 0.3193701922935181 0.0964657436723923 0.923150679599006 1.0 0.9917742699408792 8 Q99623 1 +Dna irdouble strand breaks and cellular response via atm 0.2779434713086989 0.0842927843823997 0.9328236492147024 1.0 1.0 29 Q13535,Q9UQ84,P09874,Q13315,P78527,Q00535,Q07812,P42574 8 +Myometrial relaxation and contraction pathways 0.2806627437381014 0.0752403961185251 0.9400234439719444 1.0 1.0 26 P16615,P78417 2 +Mapk pathway in congenital thyroid cancer 0.2775831873905496 0.0748835281615013 0.9403073823790012 1.0 1.0 4 P36507,Q02750,P04049 3 +Brainderived neurotrophic factor bdnf signaling pathway 0.2681789194810732 0.0680530729828035 0.9457433860397604 1.0 1.0 48 P54646,P42345,Q14012,Q99523,Q00535,Q96P70,P51812,Q7L576,Q15418,P42574,P67809 11 +Serotonin receptor 2 and elksrfgata4 signaling 0.277664233576647 0.0387330806858931 0.9691031986171276 1.0 1.0 5 P36507,P28482,Q02750,P04049 4 +Nucleotide excision repair 0.275057582383031 0.0372097808523733 0.9703177400218916 1.0 1.0 25 P28340,P41208 2 +Pyrimidine metabolism and related diseases 0.295062810400225 0.0368208080813892 0.970627882847376 1.0 1.0 7 P04818,P31350,P23921,P27708,Q05682,Q9H0P0 6 +Translation inhibitors in chronically activated pdgfra cells 0.2773622674906141 0.0260577911201705 0.9792112434268696 1.0 1.0 20 P42345,Q15418 2 +Synaptic vesicle pathway 0.2847485584963115 0.0179839500022048 0.9856516573845308 1.0 1.0 14 P12235,Q13277 2 +Dna replication 0.2678757451173658 0.0174181515325783 0.9861030285229856 1.0 1.0 27 Q99741,P49736,P25205,P49643,Q9Y619,P49005,P35251,P33991,P40937,P33993,P28340,P49642,Q9UBD5,Q07864,Q14566 15 +3q29 copy number variation syndrome 0.284024218602038 0.0067999749893391 0.9945744467548157 1.0 1.0 13 P02786,O95684,P61088,O75592 4 +Biomarkers for pyrimidine metabolism disorders 0.2784107508033833 0.0024367633290964 0.9980557460854872 1.0 1.0 7 Q9Y606,P04818,P31350,P23921,P11172,Q9H0P0 6 +Mapk cascade 0.2778264680105128 0.0013469783526358 0.9989252670936866 1.0 1.0 7 Q02750,Q96FS4,P04049,P36507,P62993,P28482 6 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a7621f62071e0e59034a3df3cfee02eced8e7f86 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Activation of nlrp3 inflammasome by sarscov2", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoe and mir146 in inflammation and atherosclerosis", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Galanin receptor pathway", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes associated with the development of rheumatoid arthritis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 and megakaryocytes in obesity", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Ldlrad4 and what we know about it", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirna targets in ecm and membrane receptors", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoblast signaling", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced nfkb survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Quercetin and nfkb ap1 induced apoptosis", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 altering angiogenesis via nrp1", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Srf and mirs in smooth muscle differentiation and proliferation", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Tamoxifen metabolism", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAR2", "AARS", "AASS", "ABAT", "ABCB1", "ABCD3", "ABCF1", "ABCF2", "ABI1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK4", "AKAP1", "AKAP10", "AKAP12", "AKAP13", "AKAP8", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH18A1", "ALDH1A2", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "AMOT", "ANAPC1", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APBB1", "APEX1", "APIP", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARG2", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARL8B", "ARMC8", "ARMC9", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG3", "ATG7", "ATG9A", "ATIC", "ATM", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATR", "ATXN10", "ATXN2L", "AURKA", "AURKB", "B3GALT6", "BAG2", "BAG3", "BAG4", "BAIAP2", "BANF1", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BCAS3", "BCAT1", "BCAT2", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BECN1", "BLM", "BLVRA", "BPTF", "BRCA1", "BRD4", "BRIX1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "C1QBP", "C21orf59", "CAB39", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPZB", "CARM1", "CASK", "CASP3", "CASP7", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC6", "CDC73", "CDCA7L", "CDH2", "CDK1", "CDK2", "CDK4", "CDK5", "CDK9", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CEP170", "CEP250", "CEP290", "CEP44", "CEP97", "CERS1", "CERS2", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHMP5", "CHORDC1", "CHRAC1", "CHTF18", "CHTF8", "CHUK", "CIP2A", "CISD1", "CIT", "CKB", "CLASP1", "CLASP2", "CLCN7", "CLIC1", "CLIP1", "CLK3", "CLPTM1L", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT10", "CNP", "COA3", "COASY", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COQ8A", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CREBBP", "CRK", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAGLB", "DARS", "DAXX", "DBNL", "DCAF1", "DCAF7", "DCP1A", "DCTD", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERA", "DERL1", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DIP2A", "DLAT", "DLD", "DLST", "DNAAF2", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJB11", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSC2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "ECT2", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP3", "EMD", "EML4", "ENAH", "ENDOG", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "EPS15L1", "ERBIN", "ERCC2", "ERCC3", "ESD", "ESPL1", "ESS2", "ETF1", "ETFA", "ETFDH", "ETHE1", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOC8", "EXOSC2", "EXOSC4", "EXOSC7", "EXOSC9", "EXTL3", "EZR", "FABP5", "FADS2", "FAF1", "FAH", "FAM120A", "FAM91A1", "FANCA", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FKBP10", "FKBP15", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAMT", "GAPDH", "GART", "GBA", "GBE1", "GCC2", "GCDH", "GCLC", "GCLM", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GID8", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GMPPB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNG5", "GNPAT", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GPT2", "GRB2", "GRSF1", "GSK3A", "GSR", "GSS", "GSTA4", "GSTCD", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F2", "GTF2H1", "GTF2I", "GTPBP4", "GTSE1", "GUSB", "GYG1", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDGF", "HEBP1", "HELLS", "HERC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUS1", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IFT52", "IGBP1", "IGF2BP1", "IGF2BP3", "IKBKB", "ILF2", "ILK", "IMP3", "IMPDH2", "INF2", "INPP4A", "INPPL1", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BPL", "IRS4", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2C", "ITPA", "IVD", "JUP", "KAT7", "KATNB1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIDINS220", "KIF1B", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC2", "KLC4", "KMT2A", "KNSTRN", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LAMB1", "LAMC1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIN28B", "LIN9", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRPPRC", "LRRC59", "LRRC8A", "LRRFIP1", "LRWD1", "LSM2", "LSM7", "LSS", "LTA4H", "LUC7L", "LZTFL1", "MACF1", "MAGED1", "MAGT1", "MAP1B", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC2", "MARCKS", "MARK2", "MARS", "MARS2", "MAT2A", "MAT2B", "MAU2", "MAVS", "MBD1", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCRS1", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MEPCE", "MFAP1", "MFGE8", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MMACHC", "MOCS1", "MOCS2", "MOGS", "MORC3", "MORF4L1", "MOV10", "MPC2", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTERF3", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTMR2", "MTMR6", "MTOR", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAM1", "NCAPG", "NCAPG2", "NCBP1", "NCBP2", "NCDN", "NCKAP1", "NCL", "NCOR1", "NCSTN", "ND1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NET1", "NEU1", "NF1", "NFATC2IP", "NIPBL", "NKRF", "NME1", "NME3", "NME7", "NONO", "NOP2", "NOTCH2", "NPAT", "NPC1", "NPC2", "NRP1", "NSDHL", "NSF", "NT5C3A", "NUBPL", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "ORC3", "OTUD7B", "OXCT1", "OXSM", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAK4", "PAPOLA", "PAPSS1", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PCNT", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDLIM5", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PEBP1", "PELO", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF6", "PHGDH", "PHLDB2", "PI4K2A", "PI4KA", "PIBF1", "PIGT", "PIK3C2A", "PIK3R2", "PIK3R4", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLCG1", "PLCG2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNKP", "PNP", "PNPLA8", "PNPO", "PNPT1", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "PON2", "POR", "POU2F1", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP4R3A", "PPP5C", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF18", "PRPF3", "PRPF38A", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB21", "RAB23", "RAB2A", "RAB3B", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RASAL2", "RB1", "RBBP4", "RBBP7", "RBM14", "RBM17", "RBM39", "RBM4", "RBM47", "RBM5", "RBMX", "RCC1", "RCN1", "RDX", "RECQL", "REL", "RELA", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRBP1", "RRM1", "RRM2", "RTCB", "RTF1", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SAR1B", "SARS", "SATB2", "SC5D", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEL1L", "SELENBP1", "SEPT11", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SFMBT1", "SFPQ", "SFSWAP", "SGK3", "SGPL1", "SH3GL1", "SH3GLB1", "SH3RF1", "SHMT1", "SHMT2", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKP1", "SKP2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35B2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SMYD3", "SMYD4", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SORT1", "SPEN", "SPNS1", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSNA1", "SSR3", "SSR4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STIP1", "STK4", "STMN1", "STRAP", "STRN", "STUB1", "STX3", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUN1", "SUPT5H", "SUZ12", "SYNE2", "TAB1", "TAF6", "TALDO1", "TAOK1", "TAP1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCF20", "TCP1", "TDP2", "TECR", "TELO2", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIMELESS", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TM7SF2", "TMED10", "TMEM43", "TMOD1", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP13", "TRMT2A", "TRRAP", "TSG101", "TSPO", "TSPYL1", "TTC19", "TTC26", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWISTNB", "TXNDC5", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBE2T", "UBE3A", "UBR2", "UBR5", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC119", "UNG", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP10", "USP32", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VASP", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS16", "VPS18", "VPS28", "VPS33A", "VPS37B", "VPS4A", "WAPL", "WARS", "WASF2", "WDCP", "WDHD1", "WDR1", "WDR35", "WDR48", "WDR5", "WDR74", "WFS1", "WIPI2", "WNK1", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YES1", "YPEL5", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM3", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ACADVL", "ACOX1", "ACP6", "AGPAT5", "AGPS", "AIFM1", "ALG1", "ALG11", "APP", "ARPC1B", "ARSA", "ASAH1", "ATG9A", "ATIC", "ATM", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATR", "BAX", "BCL2L13", "CAD", "CALD1", "CALM3", "CAMK1", "CARM1", "CASP3", "CCNB1", "CCNB2", "CDC37", "CDC6", "CDK1", "CDK4", "CDK5", "CDK9", "CERS2", "CETN2", "CHTF8", "CISD1", "CLPTM1L", "CLUH", "COA3", "COMT", "COX15", "COX2", "COX4I1", "COX6B1", "COX7A2", "CPT2", "CRK", "CSNK1A1", "CYB5B", "CYFIP1", "CYP20A1", 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b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e3835f5d0cc03879391ef415a75a564702cc07f1a695af7d103c8cece337ee4a +size 79185 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6856b80584464a5a4d6a383642d1eeb8b6dca5a8 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +er 35 88 3.163685884729212 0.0015578483310199 29.17233009708738 87.61893203883496 1.3358083950399515 0.3757472714196316 13.465054065187209 8.223393744963309 2.0429537263872786 0.4010648005920765 0.1091102983687238 0.50487672715324 0.0477492600477574 1.6769225875117026e-06 1.6898880549305213e-13 +vesicles 50 179 2.465077234932742 0.0136983720621932 42.101941747572816 169.6626213592233 0.6789633151163722 0.6006686966705359 14.133870910307197 18.74575061031192 1.1351302778834993 0.3922666308151308 0.3089702623141977 0.5084407512649732 0.4246902922528839 0.0007195592209097 1.9263050165297e-06 +golgi 14 62 2.3837310863293686 0.0171381206708567 15.631067961165048 61.19417475728155 0.6692399314943925 0.523533703348586 6.922582002252161 5.868805558877078 1.075539554450533 0.3729249549278102 0.5637945515640705 0.3928429005031874 0.2533609509960167 0.0030790050493254 0.0001041168817891 +mitochondria 5 10 2.252997746559588 0.0242592910517733 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 0.0048180551758565 0.0017760204843955 0.0066572828402184 0.003355333516566 1.665940864684324e-05 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5ecf7c9f9e80a7b07d46f95686832594b6e5c0fe --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 103.11764705882354 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..be68800ec03d543d61be674fc988fc35e45fad67 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..774ba5fdb0c8010c8512172ae20cfaaa736c3da7 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +er 0.5397445882013315 3.163685884729212 0.0015578483310199 0.0261559213283073 0.0264834216273384 88 Q07065,Q15392,Q5HYI8,Q16850,Q8NHH9,Q9UM00,Q15041,Q9Y6B6,Q13190,Q96GC9,Q9Y5M8,P48449,P48651,Q14739,O96005,P49755,Q96N66,Q96A33,O95470,O15269,Q969V3,Q969Q5,Q06136,O00264,P18085,Q9Y487,O75845,Q9P2W9,Q8TBX8,Q15363,O00767,O15173,Q9NR31,Q9NPA0,Q9NQC3 35 +vesicles 0.3846167849719916 2.465077234932742 0.0136983720621932 0.2090195507709124 0.0912250981416411 179 Q15392,O95249,P53985,Q8IY95,Q13277,O75165,Q93050,Q01968,Q5HYI8,Q9Y5X3,Q9H2V7,P20020,Q8IZ07,P11279,O15400,O15127,Q9UM00,Q15904,Q9Y5X2,Q5VW38,Q8IXU6,Q8NF37,P48449,O96005,P49755,O95470,P61020,P13473,O15269,Q969V3,Q7Z3C6,P53367,P51798,Q8NBN3,Q9BTU6,Q06136,O00264,P30825,O75845,P42345,P11166,Q8IZA0,Q15907,Q15363,P50570,Q9Y5K8,O43808,O15173,O00767,O60476 50 +golgi 0.4916589850099786 2.3837310863293686 0.0171381206708567 0.2546292449630417 0.0912250981416411 62 O15127,Q9Y6B6,Q15904,Q13190,Q7Z3C6,Q8IZA0,Q5VW38,P53367,Q15907,Q8IXU6,Q8NBN3,Q9NR31,P49755,Q9Y487 14 +mitochondria 0.7591613201047677 2.252997746559588 0.0242592910517733 0.341303708738696 0.0912250981416411 10 Q9Y277,P45880,Q969Q5,P21796,Q9NR31 5 +centrosome 0.2922987315681167 0.2090156953688568 0.8344359860897188 0.9999999999999472 0.8865882352203263 36 P41208,Q13442,O96013,P06493,Q13409,P0DP25,P48729,Q9BZD4 8 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3753f89164467f654a8c7a5512e9c42ff6683e1d --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AATF", 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sha256:829d25118abd17265d8a20a2ac8e00c8a7241d040587ad4c5b4f70ddb5b9212a +size 133994 diff --git a/panther_protein_class/consensus.joblib b/panther_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..8ec4d7e126ca7af784a934bd61ad10a1081664eb --- /dev/null +++ b/panther_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:af4603300f09496f773f581da087869cc97d50dee72ef0c1ca07112093b2ba8e +size 103510 diff --git a/panther_protein_class/df_merge.tsv b/panther_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2c0237492dbfaf1a61a358ced1e9952c372b6379 --- /dev/null +++ b/panther_protein_class/df_merge.tsv @@ -0,0 +1,13 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +serine protease 6 18 3.196689269995829 0.0013901459093959 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 4.557198944336205e-05 9.216009865625694e-05 0.0001009929501613 0.000162079776431 0.0091015487948519 +membrane trafficking regulatory protein 4 20 2.8079177008322245 0.004986296797558 4.949029126213592 18.78640776699029 1.0645815505395402 0.2320552342124929 2.3097144002673033 2.893415643517755 1.4460865220385617 0.2677048300346334 0.000882739586926 0.027703186905031 0.0016384890204764 0.008923404115777 0.043045103354355 +mitochondrial carrier protein 3 6 2.729005182430056 0.0063525705585778 3.2936893203883497 7.065533980582524 1.4583792806536486 0.1840967072966826 2.0141872967986307 1.116111686789906 1.1161599809390137 0.2507152229846449 1.0 1.0 0.1180585699575878 0.0002022933287296 0.0028040242445346 +transporter 19 56 2.617816657038192 0.0088494338406557 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 0.0699466130475088 0.4392448907866976 0.1026543028729206 0.0001217230774778 4.867773031821959e-05 +protein modifying enzyme 5 26 2.586871534739877 0.0096851693653923 6.487864077669903 24.82281553398058 0.9737051724681342 0.3238157719208961 2.575528657386725 2.871041189126622 1.1448244681235864 0.2930923238696635 0.080787090338714 0.2486824788491954 0.107004894081217 0.0026843919056765 0.06212243803085 +transmembrane signal receptor 4 7 2.584823374251795 0.0097428893495112 3.266990291262136 7.169902912621359 1.6693846681257831 0.1085289610325799 1.5770125590990791 1.7927217985188668 1.0928815816574815 0.16461969248918 0.1721884108424982 0.3651094145888684 0.2213471409258044 0.183699096822524 0.4676307579057312 +calmodulin-related 7 14 2.5139684779846383 0.0119381103738054 5.053398058252427 12.385922330097088 1.3935892727836532 0.1814075830019033 2.0222219603900085 1.786979844553702 1.206053991839631 0.2252292235861566 0.0010512986284106 0.0065792573185243 0.0016986126979642 0.0002861885476851 1.5611785984141917e-05 +oxygenase 4 8 2.403082904681752 0.0162575012310592 3.138349514563106 6.771844660194175 1.5409868347565758 0.1477866581414416 1.2914149665013366 1.041089559555361 1.2379399582807478 0.2357869798067575 0.0160900301160464 0.0060718409625537 0.0219975904219434 0.0024379570615939 0.0053032680205866 +secondary carrier transporter 6 15 2.22284242270396 0.026226427371047 6.104368932038835 14.6626213592233 1.264699085385324 0.2718921136589474 3.483843477892234 2.781747184831951 1.2916784116683784 0.322278600042778 0.0199920874816232 0.295480255529908 0.0307515849952898 0.0931141624023252 0.0569218260288664 +esterase 1 9 2.1623525079723223 0.0305910152817576 2.0679611650485437 7.684466019417476 0.7172320192268422 0.3647762514846939 1.5217653004191571 1.4253091833924298 1.0863934099472772 0.3032327374846778 0.0136086826932428 0.1026081339138497 0.018640880521655 0.0983610682747182 0.2914565107291916 +SNARE protein 5 8 2.148133919192164 0.0317031183451488 4.660194174757281 11.12378640776699 0.9288896561072936 0.3201954718639376 2.5506648592929815 2.745113440103806 1.1546709449924732 0.3042666981599379 1.0 1.0 1.0 0.5094216597603356 0.0504521665366165 +transfer/carrier protein 4 9 2.0721996373996703 0.0382468272222134 4.33252427184466 11.024271844660197 0.5751131114698911 0.3717158985009051 2.2946984989028927 1.3525930522279908 1.248808855129494 0.3186564966906889 1.0 1.0 1.0 0.0002335266734922 0.0008256536450065 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..6e8f8f31b0c49f96ec15396104b061fea5afca6a --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 156, + "title": "Average number of proteins per term", + "value": 14.89102564102564 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..27a3316efb527844593bc1ca98be178f7b25e29b --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9cca70a86b7f5c19eb6b6b6df642f08bebec1cc6 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,50 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +galactosidase 0.8841890315052399 3.3909394348311492 0.0006965349178305 0.102998107677294 0.0181778805779856 2 P16278 1 +kinase activator 0.8681446907817975 3.31570080075461 0.0009141364172948 0.1329602896119285 0.0181778805779856 2 P14635 1 +voltage-gated ion channel 0.9147942807119812 3.308482257289861 0.0009380312832054 0.1361892344660606 0.0181778805779856 3 P21796,P45880 2 +serine protease 0.8221490296570806 3.196689269995829 0.0013901459093959 0.1950810075695917 0.0197147965332509 18 P67812,Q16740,O14773,P42785,Q9H3G5,Q9HB40 6 +G-protein coupled receptor 0.906351916846408 3.059329895895542 0.0022183272438156 0.2928011931029399 0.0216286906272026 4 Q5VW38,Q9NPR9 2 +membrane trafficking regulatory protein 0.7257391562377957 2.8079177008322245 0.004986296797558 0.5415060109833975 0.0324109291841271 20 O43731,P24390,Q14108,Q8WTV0 4 +mitochondrial carrier protein 0.8986740319683233 2.729005182430056 0.0063525705585778 0.6299666356728142 0.0353928931120766 6 Q70HW3,Q9BSK2,Q9Y6C9 3 +transporter 0.5261099841127463 2.617816657038192 0.0088494338406557 0.7500904759722593 0.0431409899731966 56 P55060,Q9HD45,Q9Y619,Q9H2V7,Q567V2,O43772,P52292,O60830,Q9C0E2,Q9NR77,Q96P70,O43681,Q99595,Q9Y584,Q92973,O15397,Q9H2D1,Q9UJZ1,Q15070 19 +protein modifying enzyme 0.636841737083926 2.586871534739877 0.0096851693653923 0.7809051644640044 0.0447026687801106 26 Q6P2P2,O60725,P51812,P50897,Q86YN1 5 +transmembrane signal receptor 0.856747444888356 2.584823374251795 0.0097428893495112 0.7828882861746782 0.0447026687801106 7 O00264,Q8WUJ1,O15173,Q99720 4 +calmodulin-related 0.7490939830465912 2.5139684779846383 0.0119381103738054 0.8464226503500677 0.0487351345941844 14 P80303,P41208,Q02818,Q14257,P0DP25,Q8IYU8,Q9BRK5 7 +replication origin binding protein 0.7009918319719998 2.4863409692108 0.0129064240261524 0.8682050465544786 0.050169338506717 2 Q9UBD5 1 +amino acid transporter 0.7745739205593447 2.454824159230427 0.0140953517301984 0.8907939711191499 0.050169338506717 4 O14925,P30825 2 +primase 0.6861143523920682 2.408226565617928 0.0160302293711629 0.9196188928381406 0.0539610679158563 2 P49643 1 +oxygenase 0.8079958725992827 2.4030829046817517 0.0162575012310592 0.9224639499925956 0.0539610679158563 8 Q16850,P30519,Q6UW02,P09601 4 +major histocompatibility complex protein 0.7351985558895104 2.265244901918215 0.023497655099937 0.9755074885820026 0.066647894465276 4 P55899,P01889 2 +secondary carrier transporter 0.6771098188122101 2.2228424227039594 0.026226427371047 0.9841712907054694 0.0717775906997078 15 Q8TB61,P55011,Q9UBX3,Q9BQT8,Q96ES6,O95202 6 +esterase 0.7488464903583961 2.1623525079723223 0.0305910152817576 0.9921458656450808 0.0795366397325699 9 Q969T7 1 +SNARE protein 0.7537729891947548 2.148133919192164 0.0317031183451488 0.993433541790934 0.0810768272433314 8 O95249,O15400,Q13277,Q9P2W9,Q13190 5 +transfer/carrier protein 0.7303176680032823 2.0721996373996703 0.0382468272222134 0.997720046860686 0.0948249714051126 9 P17900,P12235,O15127,Q9Y5M8 4 +metalloprotease 0.532761094669141 1.924635382959604 0.0542749895799616 0.999834300799776 0.1276208567531554 27 P55786,P42892,P14735,P22695,Q9UIQ6,O75844,Q99797 7 +ATP-binding cassette (ABC) transporter 0.6913989948781596 1.9165884731680285 0.0552902335553469 0.9998598635212742 0.1276208567531554 10 O14678,Q03519,Q9NUT2,Q03518,P08183 5 +oxidase 0.5921776688598077 1.7813529590820183 0.0748548079035558 0.9999946451932366 0.1621854171243709 16 O43819,Q15800,Q8NB78,P14406,P14854,Q9NVS9,P13073,O75845 8 +phospholipase 0.6459431524617978 1.7202252208411632 0.0853915102277771 0.999999103199948 0.1799006856731517 11 Q8N2A8,Q8NHP8 2 +oxidoreductase 0.4522697431729754 1.7064689265826607 0.0879208069653947 0.9999994177928244 0.1804690248237049 43 O43169,Q8N4Q0,O43396,O14949,P00403,Q8N0U8,O43676,Q86Y39,P16435 9 +ATP synthase 0.5141823399560679 1.4911414108605388 0.1359243720730794 0.9999999998735049 0.2604092683222164 20 O75964,P56385,Q93050,Q96IX5,Q6IN85,Q15904,P24539,Q9Y487,P06576 9 +glycosyltransferase 0.4975700489181346 1.4875038206402122 0.1368817948873188 0.9999999998935948 0.2604092683222164 23 Q10472,O60512,P46977,Q96L58,P46976,Q9BT22,Q8NAT1,Q8N4A0,Q8NBN7 9 +reductase 0.4546193002013075 1.467757057971478 0.1421702257495039 0.999999999959208 0.2604794137416908 32 Q15392,O76062,Q9H7Z7,P00374,Q06136,Q14739,Q9UDW1 7 +peroxidase 0.5975360705951029 1.445513685480171 0.148313651755692 0.9999999999867067 0.2659417203895167 5 P32119 1 +ion channel 0.5611166261973484 1.259651048651009 0.2077952714392676 1.0 0.3523485037448451 5 Q9C0H2 1 +acyltransferase 0.460274276491058 1.1298249180717783 0.2585500062432979 1.0 0.4208209932243716 20 Q9NUQ2,P49354,Q8NCC3,P49356,P23786 5 +kinase 0.4574936946006724 1.1110658900934176 0.2665399887381363 1.0 0.4286622499293739 20 Q53H12,Q8WVC6,P52429,Q9BRR6,P52789,Q8TBX8,Q9HA64,Q9BTU6,Q13057 9 +DNA ligase 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.4729747376096753 2 P18858 1 +membrane traffic protein 0.3477296210927084 0.9365557874155112 0.3489871034558032 1.0 0.528562991641799 66 Q9NX40,Q96RL7,Q12907,P43307,A6NIH7,O00203,Q9H223,Q96PC5,Q13432 9 +homeodomain transcription factor 0.4049008168028182 0.8201656424355405 0.4121216853514344 1.0 0.5921321891678609 2 O94776 1 +histone 0.4684733343338169 0.751334803289766 0.4524511887901905 1.0 0.617348091740424 10 P07305,P16402,P84243,P10412,Q92522,P16403 6 +transferase 0.3660672689053562 0.7472120194028149 0.4549355899540148 1.0 0.617348091740424 32 P43490,Q9NRN7,P37268,Q06520,Q7LGA3,O43505,O15217,Q2TAA5 8 +tubulin 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.617348091740424 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +primary active transporter 0.3882188923642867 0.714858715797283 0.4746963493624951 1.0 0.6329284658166602 23 Q9NS69,Q15388,Q9H9B4,O75381,Q6NTF9,P20020,Q9BUN8,P16615,Q6P4A7,Q96NB2,Q8N4H5 11 +vesicle coat protein 0.3704403820371635 0.7016147093916455 0.4829194758465527 1.0 0.6360923643004608 27 Q15363,P49755,Q9Y3B3,P53367 4 +DNA metabolism protein 0.3341995448875938 0.6139034794363046 0.5392791108213602 1.0 0.6895700105584606 41 P09874,Q9Y248,Q9UGN5,P28340,Q13426,Q8IWS0,Q8WVB6,Q07864,Q14566 9 +RNA helicase 0.4090464820455842 0.5858656514098441 0.5579658013335531 1.0 0.6963413200642743 14 Q7Z478,Q8IY37,Q92620,Q9H2U1,Q9H6S0 5 +nucleotide phosphatase 0.4120788124379386 0.5156713827809192 0.6060839450214173 1.0 0.7503896462169928 5 Q9H857,P49902 2 +DNA helicase 0.389880081895279 0.3771141109403073 0.7060888050635881 1.0 0.8386325368653742 11 P54132,P18074,P46063,O60264,Q96RR1,P13010,P12956,P28370,Q9H4L7,P19447 10 +damaged DNA-binding protein 0.3382487458985091 0.3584987405449943 0.7199701102364857 1.0 0.8444762195255021 3 P54725 1 +cysteine protease 0.3046355851435193 0.2326569743591754 0.8160277818867836 1.0 0.914660071262958 27 Q13510,Q70CQ2,Q13867,Q14674,Q9UPU5 5 +general transcription factor 0.2827148235574168 0.1167823864933776 0.9070325017771212 1.0 0.9852204896598064 31 Q16625,Q9UBK9,P35269,Q9Y6J9,O75448 5 +hydrolase 0.2931425379761849 0.113752115825688 0.9094342981475136 1.0 0.9852204896598064 23 P15289,O60502,P15586,Q96C86,P07099,Q9BPU6,Q96CN7,O95336 8 +G-protein modulator 0.3107476635514074 0.0786485862263369 0.9373121409775214 1.0 1.0 6 P24386,P50395,Q9H2M9,P52565,P11274 5 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..380f3f67523f04783181ff5379a17936a1d08f48 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "Lambda repressor-like transcription factor", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "Rel homology transcription factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "amylase", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "hydroxylase", "immunoglobulin receptor superfamily", "integrin", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AGPAT4", "AGPAT5", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMPD2", "ANAPC1", "ANAPC7", "ANKFY1", "ANKHD1", "ANKRD17", "ANKS1A", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APIP", "APOL2", "APP", "APRT", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF7", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARMC9", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "AS3MT", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATAD5", "ATE1", "ATG3", "ATG4B", "ATG7", "ATL2", "ATL3", "ATM", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATR", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BAG2", "BAG6", "BAIAP2", "BAP18", "BAZ2A", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCKDHB", "BCKDK", "BCLAF1", "BCR", "BDH2", "BECN1", "BLM", "BLMH", "BLOC1S1", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRIX1", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CBR1", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC6", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKN2AIP", "CEBPZ", "CENPB", "CEP170", "CEP250", "CEP97", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHEK1", "CHEK2", "CHERP", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHUK", "CIT", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLIP1", "CLK3", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT4", "CNOT7", "CNP", "COA3", "COASY", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC22", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDT", "DEK", "DENR", "DERA", "DERL1", "DERL2", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "ENO2", "ENY2", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERH", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXO1", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EZR", "FAHD1", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2B", "GATB", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GID8", "GINS1", "GINS2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNE", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOSR1", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR108", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACL1", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK1", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPE1", "HTATSF1", "HUS1", "HUWE1", "IAH1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INTS11", "INTS6", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BP1", "IRF2BPL", "ISG20L2", "ISOC1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITPA", "ITPK1", "ITSN2", "IVD", "JMJD6", "KARS", "KAT7", "KCTD10", "KCTD12", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KLC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LENG8", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT4", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8A", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTN1", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAN1A2", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED17", "MED21", "MED23", "MED24", "MED4", "METAP2", "METTL13", "METTL25", "METTL7B", "MFAP1", "MFGE8", "MFSD3", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMS19", "MOCS3", "MOGS", "MON2", "MORF4L1", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL50", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPD3", "NCBP1", "NCBP2", "NCDN", "NCKIPSD", "NCOA5", "NCOR1", "ND1", "NDC80", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4", "NEDD4L", "NENF", "NET1", "NEU1", "NF1", "NHP2", "NIP7", "NIPBL", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OTUB1", "OTUD7B", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B2", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAXBP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXP", "PEBP1", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIK3R2", "PIK3R4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "POMP", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RAF1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBM47", "RBM7", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REL", "RELA", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RIOK1", "RIOK2", "RIPK1", "RNASEH2A", "RNF2", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RSU1", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SALL2", "SAMHD1", "SAP18", "SAP30BP", "SARM1", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SC5D", "SCAF1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL1", "SCYL2", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGK3", "SHMT1", "SHMT2", "SHPRH", "SIGMAR1", "SIN3A", "SIPA1", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC35B2", "SLC39A14", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLMAP", "SLU7", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX14", "SNX2", "SNX27", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPNS1", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STK4", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SULT2A1", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNJ2BP", "TAB1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARBP1", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TCP11L1", "TDRKH", "TECR", "TERF2IP", "TES", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM9", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TM7SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM87A", "TMLHE", "TMOD1", "TMOD3", "TMPO", "TMX2", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAF2", "TRAP1", "TRAPPC4", "TRIM26", "TRIM27", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSPYL1", "TST", "TSTA3", "TTC28", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBP1", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UCK2", "UFL1", "UGDH", "UGGT1", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNG", "UPF2", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP3", "UTP6", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VKORC1L1", "VMP1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS28", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS53", "VPS72", "VRK1", "VRK2", "VRK3", "WARS", "WASF2", "WASHC5", "WDHD1", "WDR1", "WDR33", "WDR4", "WDR74", "WDR82", "WNK1", "WWP2", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", 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sha256:81792ed35fd1605852ecfbc71f21968a96115ffab1dc15b2a52fb6ef383b79c6 +size 126167 diff --git a/pharos_dto/consensus.joblib b/pharos_dto/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..20a605bb221d4aed6245d5ac7fa6f457bc8cbd4e --- /dev/null +++ b/pharos_dto/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cc7ec89ab7ff428847648d31f763871fd7f79edc8d0df0922a8db61041f72c43 +size 776471 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4e41804f19ae6a33a5c58e9b211bca0ddbcb7018 --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,15 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Transporter 68 182 4.781509987633798 1.7398335752094596e-06 57.59466019417476 188.27912621359224 1.4971900036635353 0.4160578104205245 21.77919356765414 18.57070590158326 1.926868489654782 0.421013047757716 0.0445306126911808 0.4312193088227247 0.018562044491558 7.582313604368794e-08 4.776099627994349e-10 +SLC superfamily of solute carriers 22 41 3.469994747150431 0.0005204685435187 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 0.4380881290336841 0.5945506711510287 0.2548852757682844 0.0001337568188117 0.0002065239344139 +Receptor 12 33 3.198191181290281 0.0013829256470496 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 0.055218015958174 0.0951142950684223 0.0189133156354044 0.004144931190839 0.0734050276370658 +SLC25 family of mitochondrial transporters 12 20 3.134812262604202 0.0017196412523967 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.2613762066892051 1.0 0.048990890514732 1.7091972697716228e-07 9.11507505405056e-09 +Calcium-binding protein 8 21 2.660348205173431 0.0078059904358318 6.135922330097087 18.021844660194176 1.3650952896045327 0.2072953623045914 2.3371152398743247 2.2037057261181348 1.237653756718734 0.2545563939054063 0.000513634171134 0.0014522342124754 0.0009611330378982 0.0007908116200209 0.0003165443223373 +Intracellular calcium-sensing protein 7 16 2.5789072269811446 0.0099113400978514 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.0021760960656691 0.0106429023881486 0.0034893000144238 0.0009447024772989 0.0001122473104027 +Calmodulin 7 16 2.5789072269811446 0.0099113400978514 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.0021760960656691 0.0106429023881486 0.0034893000144238 0.0009447024772989 0.0001122473104027 +Phospholipase 1 5 2.5670213504558097 0.010257629636329 0.9150485436893204 3.7305825242718447 0.7966129457254134 0.3188877353015109 0.8533581565055661 1.071582012810982 1.2006971708387306 0.2905331526823088 1.0 1.0 0.1837383274168749 0.090818300458346 0.2730711037423907 +Mitochondrial nucleotide transporter subfamily 6 8 2.5647634906472168 0.0103246154280309 4.216019417475728 9.065533980582524 1.5870110662923598 0.1668197633609344 2.720728714423222 1.1029864386277723 1.1616247375257451 0.2431804664231326 1.0 1.0 0.1349531130589082 1.972516813028553e-05 2.867248301904128e-06 +Signaling 9 20 2.336621279218357 0.0194588850126844 5.66747572815534 18.009708737864077 1.330299096012152 0.2668377480945127 2.507969905227609 1.6994867622232877 1.0107551340834326 0.2926688105318188 0.5144097806447996 1.0 0.5741114914523541 0.0621642703962852 0.1369287463653804 +SNARE protein 5 8 2.148133919192164 0.0317031183451488 4.555825242718447 10.6626213592233 0.9494792984446184 0.3117420251981136 2.5225757464631977 2.583604188764985 1.1633177546874711 0.3031193116521645 1.0 1.0 1.0 0.4846912912858679 0.0402069493791732 +ABCB subfamily 4 6 2.026816802092948 0.0426811514866647 1.4660194174757282 4.152912621359223 0.6118345866928353 0.3423864070958426 1.2012577064447347 1.3414295599134654 1.163285659538929 0.2820720534042253 0.0633191306420368 1.0 0.0743799864466655 0.0148625463558957 0.0003337445501144 +ATP-binding cassette transporter family 4 7 2.014022931684083 0.0440071259458487 2.2135922330097086 6.097087378640777 0.6703089129361733 0.3321717891455754 1.6917876191440782 1.952168637803411 1.1544628029909134 0.2803059295197611 0.1439609493286736 1.0 0.1677870330809631 0.0762921742488627 0.0120515986398723 +Reductase 7 17 2.0026671808563044 0.0452130236954746 4.563106796116505 16.313106796116504 1.2016212969729014 0.3130807121312539 1.9089462498224232 1.180966799206311 0.8349037556988175 0.2876306629725971 0.0230572634873926 0.1330370821365251 0.0026246094830452 0.0005910649168726 5.212592946325474e-05 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..6ed0718b3af576e79b8a45085eb948b3465d264c --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 2122, + "title": "Average number of proteins per term", + "value": 3.1366635249764374 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..431582358d971dff6d9d5221fcd6e6dd7d9af791 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..bed9a5ee68c115727ce36ad180fcff2c57945e26 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,86 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transporter 0.5471023766609 4.781509987633798 1.7398335752094596e-06 0.0036851232638048 0.0009062360638866 182 Q9HD45,O95249,Q9Y3B3,P24390,P53985,Q13277,Q9NUT2,Q93050,P55011,Q9Y619,Q9H9B4,Q9BQE5,Q9H2V7,Q9BQT8,P20020,O43772,O95202,P52292,P11279,P06576,Q15043,Q14444,Q9C0E2,O15400,Q9BSK2,Q9BVK6,Q9Y6C9,Q8TB61,Q13190,Q9UBX3,Q8IXU6,P08183,P24539,Q96ES6,P12235,O43731,O95487,P49755,Q9Y584,P56385,Q03519,P13473,Q92973,Q03518,P12236,Q9Y6M7,Q9Y487,P30825,Q96NB2,Q70HW3,O14678,P11166,Q15388,P17900,Q9P2W9,Q12907,Q99523,O00203,Q15363,O43808,Q9Y5K8,Q9NZJ7,P05141,Q92544,O75027,Q9H2D1,P16615,Q15070 68 +SLC35 family of nucleotide sugar transporters 0.9480746791131812 3.683651079849408 0.0002299169089834 0.3861101570550074 0.0012672303399035 2 Q8TB61 1 +RSK subfamily 0.9364060676779402 3.6309845452341096 0.0002823420932578 0.4507571126851576 0.0014301811297834 2 P51812 1 +RSK family 0.9364060676779402 3.6309845452341096 0.0002823420932578 0.4507571126851576 0.0014301811297834 2 P51812 1 +Miscellaneous SLC25 mitochondrial transporters 0.9294049008168004 3.599216999525182 0.0003191767710333 0.4920647089049773 0.0015478169224604 2 Q9Y6C9 1 +SLC superfamily of solute carriers 0.6768971113139027 3.469994747150431 0.0005204685435187 0.6686969490700253 0.0020278789475966 41 P53985,P55011,Q9Y619,Q9H2V7,Q9BQT8,O43772,O95202,Q15043,Q9BSK2,Q9Y6C9,Q8TB61,Q9UBX3,Q8IXU6,P12235,P12236,Q96NB2,P30825,Q70HW3,O43808,Q9NZJ7,P05141,Q9H2D1 22 +SLC56 Sideroflexins 0.8474329054842509 3.2175056483334763 0.0012931048086888 0.935799485500436 0.0036711329476731 2 Q96NB2 1 +Receptor 0.6844736006134743 3.1981911812902815 0.0013829256470496 0.9469541815895026 0.0038260341890996 33 P57105,Q8WTV0,Q9NR77,O75381,A6NIH7,Q13641,Q6NTF9,Q14108,Q567V2,Q9BUN8,Q13432,Q9UQB8 12 +SLC25 family of mitochondrial transporters 0.7833267581492319 3.134812262604202 0.0017196412523967 0.9740665047360416 0.0044703020076343 20 Q70HW3,Q9BSK2,Q9Y6C9,Q9Y619,Q9UBX3,O43808,Q9NZJ7,Q9BQT8,O43772,P12236,P12235,Q9H2D1 12 +Aspartic protease 0.8556401519358838 3.0383460070593347 0.0023788064905516 0.993615236394796 0.0056706842760147 3 Q5BJF2 1 +Ca2+-ATPases 0.843102561986426 2.9798932401413425 0.0028834885957003 0.9978181922143976 0.0065760182453073 3 P16615 1 +PIKK family 0.8572679509632148 2.839414622706266 0.0045196387963188 0.9999331067331813 0.0091952766306698 4 P42345,Q13315,Q13535 3 +Calcium-binding protein 0.6922462263288981 2.660348205173431 0.0078059904358318 0.9999999400227526 0.0139430233205683 21 P80303,P41208,Q02818,Q14257,P0DP25,Q8IYU8,P43307,Q9BRK5 8 +Intracellular calcium-sensing protein 0.7315389558364738 2.5789072269811446 0.0099113400978514 0.9999999993386808 0.016885154222538 16 P80303,P41208,Q02818,Q14257,P0DP25,Q8IYU8,Q9BRK5 7 +Calmodulin 0.7315389558364738 2.5789072269811446 0.0099113400978514 0.9999999993386808 0.016885154222538 16 P80303,P41208,Q02818,Q14257,P0DP25,Q8IYU8,Q9BRK5 7 +Phospholipase 0.8296943622704287 2.5670213504558097 0.010257629636329 0.999999999685204 0.0173439761659683 5 Q8NCC3 1 +Mitochondrial nucleotide transporter subfamily 0.8432257104294194 2.5647634906472168 0.0103246154280309 0.999999999727319 0.0174294621625153 8 Q70HW3,Q9BSK2,O43808,Q9H2D1,P12236,P12235 6 +SLC12 family of cation-coupled chloride transporters 0.7132438739789803 2.55012182195355 0.0107685283534415 0.9999999998947564 0.0179623079860047 2 P55011 1 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.7772955725541358 2.467772329671409 0.0135956760569715 0.9999999999997576 0.0214977828561055 4 Q9UBX3 1 +PDHK family 0.7221808185322356 2.3932190880980233 0.0167012649505371 0.9999999999999996 0.0253505609621171 3 Q15120 1 +Signaling 0.6465332454558297 2.336621279218357 0.0194588850126844 1.0 0.028875352445396 20 Q8WUJ1,P43490,Q07820,Q07812,P17931,O15173,O00264,Q7Z4V5,Q96PC5 9 +SNARE protein 0.7537729891947548 2.148133919192164 0.0317031183451488 1.0 0.042849692438475 8 O95249,O15400,Q13277,Q9P2W9,Q13190 5 +Kinase activator 0.7023569423336067 2.1038977895735176 0.0353873638518948 1.0 0.0466989963269409 4 P14635,O95067 2 +STE7 family 0.6158109684947576 2.029162988060603 0.0424416920225987 1.0 0.0538966310424623 2 P36507 1 +ABCB subfamily 0.7425834386314556 2.026816802092948 0.0426811514866647 1.0 0.0541359255557098 6 Q03518,Q03519,Q9NUT2,P08183 4 +ATP-binding cassette transporter family 0.7329950126439092 2.014022931684083 0.0440071259458487 1.0 0.0553873791560445 7 Q03518,Q03519,Q9NUT2,P08183 4 +Reductase 0.6208542934585408 2.0026671808563044 0.0452130236954746 1.0 0.0566363850541896 17 O95881,Q15392,O76062,Q9H7Z7,P00374,Q14739,Q9UDW1 7 +Esterase 0.6866595145699137 1.9313925884497969 0.0534345210191 1.0 0.065090731115115 11 Q969T7 1 +Membrane trafficking regulatory protein 0.5772939152602948 1.9030740441760197 0.0570308842482516 1.0 0.0686051793507879 20 O43731,P24390 2 +Mitochondrial amino acid transporter subfamily 0.6845914169291217 1.8809486601629652 0.0599789029935011 1.0 0.0715029394113536 5 O43772 1 +Oxidoreductase 0.3902563025360743 1.8312220145133065 0.0670674121362715 1.0 0.0780558912935596 118 Q15392,Q13423,Q96CU9,P14406,O43169,Q14534,Q8N4Q0,Q16850,Q9P0J0,Q8N0U8,P21912,O76062,Q9H7Z7,P32119,P00374,Q14739,O15260,P03886,P00403,Q9UDW1,O95881,Q15800,P49748 23 +P-type ATPases 0.6717540911602702 1.8177436614886624 0.0691033210911453 1.0 0.0799176166076105 5 P16615 1 +Phosphatase inhibitor 0.6859611050981625 1.7874344223154883 0.0738673022709108 1.0 0.0845449921353143 7 P55209,Q99733 2 +Atypical group 0.667498271295686 1.7601190285239705 0.078387627078482 1.0 0.088776149642888 9 P42345,Q13535,Q15120,Q13315,P78527 5 +Oxygenase 0.643768561456674 1.6786704567293829 0.0932162867396564 1.0 0.1029162125190171 5 Q16850 1 +Cell adhesion 0.6367238037523945 1.643399373131239 0.1003003297486233 1.0 0.1089238995530085 5 Q9Y5V3 1 +Glycosyltransferase 0.5620901606374288 1.6003673908943008 0.1095171047416099 1.0 0.1170757160008545 16 Q10472,Q10471,O60512,P46977,P46976,Q9BT22,Q8NAT1,Q8N4A0 8 +Protease 0.3749825586025364 1.5994649963798764 0.1097173203021422 1.0 0.1172306916823493 116 P55786,Q9UIQ6,Q8TCT9,P49915,Q5BJF2,Q13510,P42892,P67812,P42785,Q9H3G5,Q9HB40,P14735,O75844,Q70CQ2,P22695,O14773,P10619,Q99797,Q8NHP8,Q9NZ08,Q66K14 21 +Lipase 0.6480693352590459 1.5744465714096725 0.1153842443146095 1.0 0.1222393242314535 6 Q8NCC3 1 +Serine protease 0.4743572398930339 1.5616855805167764 0.1183620773520688 1.0 0.1248952402491745 29 P67812,O14773,P42785,Q9H3G5,Q9HB40 5 +Growth factor 0.6155455454016888 1.5367868610145896 0.1243455119777245 1.0 0.1306243447607582 5 Q96PC5 1 +ROCK subfamily 0.517502917152869 1.4733689985022052 0.1406515648972508 1.0 0.1474617691264655 2 Q13464 1 +Peroxidase 0.5975360705951029 1.445513685480171 0.148313651755692 1.0 0.1553413470017662 5 P32119 1 +Oxidase 0.5006416521986647 1.4346083443413562 0.1513987354510704 1.0 0.1584162310784868 21 Q15800,O15260,P49748,P14406,O43169 5 +Metalloprotease 0.4290534226185048 1.4029141068772093 0.1606424536897746 1.0 0.1679228013446806 38 P55786,P42892,P14735,P22695,Q9UIQ6,O75844,Q99797 7 +CDK family 0.6029344738063251 1.402199328469332 0.1608557321358168 1.0 0.1680629559784359 8 P50750,P06493,P11802,Q00535 4 +AGC group 0.5452342657998641 1.378891520517605 0.1679282029689877 1.0 0.1751935332842634 14 P51812 1 +BUB family 0.4862893815635987 1.2921855496080588 0.1962928947627169 1.0 0.204584244934423 2 O43683 1 +CAMK2 family 0.4687864644107379 1.1901401096026412 0.2339913278189533 1.0 0.2435162322863261 2 Q13555 1 +V-type ATPase 0.5543884192254778 1.1538679894272317 0.248554294611011 1.0 0.2584185267832266 8 Q9Y487 1 +DMPK family 0.5178050204319962 1.150374480832358 0.2499896661140965 1.0 0.2597835805553932 4 O14578,Q13464,Q9Y5S2 3 +Phosphatase modulator 0.5420286786212495 1.1134087858933055 0.2655329033153171 1.0 0.2756657636179564 9 P55209,Q99733 2 +DNA helicase 0.5215586304199465 1.1112448561040131 0.2664629682536352 1.0 0.2764960482318895 12 P49736,P25205,P46063,Q96RR1,P12956,P33991,P28370,P33993,Q9H4L7,Q14566 10 +DNA ligase 0.4390315052508792 1.0167913182105666 0.30925271305248 1.0 0.3205834182204995 2 P18858 1 +Ion channel 0.5194412323723605 0.97490880308042 0.3296054990591559 1.0 0.3415150727556293 8 P51798,Q9C0H2,Q8NE86 3 +Lipid kinase 0.4862300600661657 0.8771644101835 0.380397343878879 1.0 0.3935656575870216 5 Q8TBX8 1 +F-type and V-type ATPases 0.4393277089599377 0.8151277524668606 0.4149991873993852 1.0 0.4287382062616823 15 P56385,Q93050,P24539,Q9Y487,P06576 5 +Protein arginine methyltransferase 0.4471687098657385 0.7798009962354105 0.4355080198799617 1.0 0.4497070648103546 4 O60678,Q86X55,O14744 3 +CK2 family 0.4201925882696399 0.7688708240662305 0.4419699991367658 1.0 0.4561577520273429 3 P19784,P68400 2 +Tubulin 0.4792640186916025 0.7431283513416749 0.4574039763467816 1.0 0.4718576751618233 6 P04350,P68371,P07437,Q9BUF5,Q13885 5 +Histone 0.4617155744747351 0.7353740217997556 0.4621117386047317 1.0 0.4762511458568434 11 P16403,P16402,P10412,Q92522 4 +Nucleotide phosphatase 0.4725669815116645 0.7238130133888925 0.4691805389600287 1.0 0.4828327369899035 7 Q9H857,P49902,O43681 3 +Small GTPase 0.3780700423383608 0.6443933770108811 0.5193203781731242 1.0 0.5339136833737256 23 Q96P70,P50570,Q15382,O15397 4 +Methyltransferase 0.4163573293891539 0.6268036032475841 0.5307879812999263 1.0 0.5449115124907807 14 P21964,P31939,Q6UX53 3 +Translation initiation factor 0.3815032355178002 0.6234275839649007 0.5330035760857066 1.0 0.546921464436107 21 O75153 1 +Na+/K+-ATPases 0.3599766627771251 0.5714315348065898 0.5677071579300041 1.0 0.5808459928290591 2 P05023 1 +RIO family 0.3535589264877497 0.5374708818974362 0.5909423930393616 1.0 0.6040364923070931 2 Q9BRS2 1 +Extracellular matrix glycoprotein 0.3879159369527214 0.4867294261409012 0.6264500891329263 1.0 0.6397146723484455 4 Q32P28,Q96CW1,Q9Y2T2 3 +CAMKL family 0.3876341680576956 0.4854114860695074 0.6273844863115419 1.0 0.6403606926181298 4 P54646 1 +Helicase 0.3398951036816532 0.4276199513612179 0.6689278379068928 1.0 0.6811251785213179 25 P49736,Q7Z478,P25205,Q96RR1,A3KN83,Q14562,Q92620,P33991,P12956,P33993,Q6P158,Q9H4L7,Q8IY37,Q14566 14 +F-type ATPase 0.4085664625275915 0.426134440298542 0.6700098857156618 1.0 0.6812462757492258 7 P24539,P56385 2 +Guanyl-nucleotide exchange factor 0.3736135434909585 0.4210655193174055 0.6737072391221055 1.0 0.6846775677285 4 Q96N67,P11274,Q9Y4G8 3 +Histone deacetylase 0.3838890635476268 0.3900860802476361 0.6964728954953379 1.0 0.7074751001632872 5 Q9UBN7 1 +Cysteine protease 0.304205246864357 0.3563119864300181 0.7216069337501283 1.0 0.7312559280887164 43 Q92643,Q13510,Q4KMP7,Q70CQ2,Q8NHP8,Q13867,Q14674,P49915,Q66K14,P42574 10 +Vesicle coat protein 0.3206425075841115 0.3000177646348181 0.7641636052276717 1.0 0.7729052289290369 25 Q15363,P49755,Q9Y3B3,Q9BVK6 4 +Protein kinase 0.282877829303897 0.2314580055537721 0.8169590063887426 1.0 0.8255176245509104 90 P54646,O14965,Q13546,P42345,Q13535,P11802,Q15120,P50750,P06493,Q13315,P78527,Q00535,P51812,P48729,Q15418,P54619,Q96GX5 17 +Translation factor 0.304060875688578 0.2289411175396233 0.8189146819740887 1.0 0.8270999310561714 27 O75153,P55010,P29692 3 +Acyltransferase 0.3525742371704757 0.2158665872453489 0.8290917425620725 1.0 0.8369803414446803 11 P49356,P49354 2 +G-protein 0.2948554924053119 0.196643646230341 0.8441064126559734 1.0 0.851732671258191 31 Q8NHH9,P55060,Q15382,Q96P70,P50570,O15397 6 +Immune response 0.3462257667851265 0.1822739774190875 0.8553677195872054 1.0 0.8622756774176008 6 Q9NX40 1 +Deaminase 0.2963662992828153 0.1264725425190389 0.8993578823960009 1.0 0.9061906108472524 4 Q01433 1 +Eraser 0.3174317234365074 0.090862740391403 0.9276016565418704 1.0 0.9333194476917254 8 Q9UBN7,Q8IXJ6 2 +CMGC group 0.280117576655573 0.0239611926501699 0.9808835635913352 1.0 0.9864620483131818 18 P50750,P06493,Q00535 3 +STE20 family 0.2847546728972002 0.0202681650594894 0.9838294511703828 1.0 0.9889559902338002 6 Q7L7X3,Q13043,O96013,Q13177,O95819 5 +STE group 0.2849210987726506 0.0100830954621211 0.9919549901270052 1.0 0.996651746709046 8 Q7L7X3,Q13043,Q02750,O96013,Q13177,P36507,O95819 7 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3895d1b7822964d715907daf8bf7ce39c834401d --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1,4-alpha-glucan-branching enzyme", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S16, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L13, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L16, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L20, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L22, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L9, mitochondrial", "39S ribosomal protein S18a, mitochondrial", "4-aminobutyrate aminotransferase, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase catalytic subunit alpha-2", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AMP deaminase 2", "AMPK subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 10, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family B member 8, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family D member 4", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "ATR subfamily", "AUR family", "Abl interactor 1", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase 4, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Adenylyltransferase and sulfurtransferase MOCS3", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine aminotransferase 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase family 16 member A1", "Aldehyde dehydrogenase, mitochondrial", "Aldolase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amylase", "Amyloid-beta A4 protein", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Ankyrin repeat and SAM domain-containing protein 1A", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Antigen peptide transporter 1", "Antigen peptide transporter 2", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis regulator BAX", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Arginase-2, mitochondrial", "Armadillo repeat protein deleted in velo-cardio-facial syndrome", "Arsenite methyltransferase", "Arylsulfatase A", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atlastin-3", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "Aurora kinase a", "Aurora kinase b", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beclin-1", "Beta-1,4-galactosyltransferase 3", "Beta-adducin", "Beta-arrestin-2", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "Bifunctional coenzyme A synthase", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biogenesis of lysosome-related organelles complex 1 subunit 1", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, cytosolic", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breakpoint cluster region protein", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 4", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK1 family", "CAMK2 family", "CAMKL family", "CAP-Gly domain-containing linker protein 1", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 3", "CCR4-NOT transcription complex subunit 4", "CCR4-NOT transcription complex subunit 7", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDK9 subfamily", "CDKN2A-interacting protein", "CHK1 subfamily", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CLIP-associating protein 2", "CLK family", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CRK7 subfamily", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium-regulated heat-stable protein 1", "Calcium/calmodulin-dependent protein kinase type 1", "Calcium/calmodulin-dependent protein kinase type ii subunit delta", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calmodulin-3", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calsyntenin-3", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Caspase-3", "Caspase-7", "Cat eye syndrome critical region protein 2", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Centrosomal protein of 170 kDa", "Centrosome-associated protein CEP250", "Chaperone", "Chaperonin", "Charged multivesicular body protein 5", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel CLIC-like protein 1", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "Citron rho-interacting kinase", "ClC-7/CLCN7 subfamily", "Class I transporters", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Condensin complex subunit 1", "Condensin-2 complex subunit D3", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Coronin-7", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4A", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cullin-associated NEDD8-dissociated protein 2", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 11b", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 13", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 9", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease ATG4B", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytokine receptor", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoplasmic dynein 2 heavy chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic 5'-nucleotidase 3A", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic carboxypeptidase 1", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "D-dopachrome decarboxylase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase delta subunit 2", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication complex GINS protein PSF1", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-binding protein SATB2", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase I subunit RPA43", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC2", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase III subunit RPC5", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(14)-sterol reductase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxycytidylate deaminase", "Deoxyribose-phosphate aldolase", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Derlin-2", "Desmocollin-2", "Desmoglein-2", "Desmoplakin", "Diacylglycerol kinase epsilon", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropyrimidinase-related protein 2", "Dihydropyrimidinase-related protein 3", "Dihydropyrimidinase-related protein 5", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Diphthine methyl ester synthase", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 2", "Dual specificity protein kinase clk3", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dystonin", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase CBL", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase NEDD4", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase ZNF598", "E3 ubiquitin-protein ligase listerin", "EF-hand domain-containing protein D2", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER lumen protein-retaining receptor 3", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "ETS-related transcription factor Elf-2", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Endodeoxyribonuclease", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelin-converting enzyme 1", "Engulfment and cell motility protein 2", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Epidermal growth factor receptor substrate 15", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4E type 2", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 4", "Exocyst complex component 5", "Exocyst complex component 6B", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP41", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "G2/mitotic-specific cyclin-B2", "GC-rich sequence DNA-binding factor 2", "GDP-L-fucose synthase", "GDP-mannose 4,6 dehydratase", "GEK subfamily", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTP-binding protein Rheb", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-enolase", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General transcription factor IIF subunit 1", "General transcription factor IIF subunit 2", "General transcription factor IIH subunit 1", "General vesicular transport factor p115", "Geranylgeranyl transferase type-2 subunit alpha", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucose-induced degradation protein 8 homolog", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase catalytic subunit", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamine-rich protein 1", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycogenin-1", "Glycosidase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgi pH regulator family", "Golgi ph regulator b", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 7", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HDAC class IIb", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase 6", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SETD2", "Histone-lysine N-methyltransferase SETD7", "Histone-lysine N-methyltransferase SMYD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Huntingtin-interacting protein 1", "Huntingtin-interacting protein 1-related protein", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "IKK family", "ILK subfamily", "IRAK family", "ITPK1 family", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin receptor superfamily", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inhibitor of nuclear factor kappa-b kinase subunit alpha", "Inhibitor of nuclear factor kappa-b kinase subunit beta", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol polyphosphate 5-phosphatase OCRL-1", "Inositol-tetrakisphosphate 1-kinase", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrator complex subunit 6", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Interleukin-1 receptor-associated kinase 1", "Intermediate filament", "Intermediate filament binding protein", "Intersectin-2", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Intracellular chloride channel (icc) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF1B", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF3A", "Kinesin-like protein KIFC1", "Kinetochore protein NDC80 homolog", "Kinetochore protein Nuf2", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lactadherin", "Lambda repressor-like transcription factor", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit beta-1", "Laminin subunit gamma-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Lathosterol oxidase", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat flightless-interacting protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Leukocyte elastase inhibitor", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysophospholipid acyltransferase LPCAT4", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "M-phase inducer phosphatase 3", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAGUK p55 subfamily member 7", "MAPK family", "MAPKAPK family", "MAPKAPK subfamily", "MARK subfamily", "MAST family", "MBT domain", "MCU family", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MSN subfamily", "MST subfamily", "Magnesium transporter protein 1", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "Map kinase-activated protein kinase 3", "Mediator of RNA polymerase II transcription subunit 14", "Mediator of RNA polymerase II transcription subunit 21", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D1", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methionine--tRNA ligase, mitochondrial", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Methyltransferase-like protein 7B", "Microfibrillar-associated protein 1", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1A", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial cardiolipin hydrolase", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import inner membrane translocase subunit Tim22", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 3", "Mitogen-activated protein kinase kinase kinase 7", "Mitogen-activated protein kinase kinase kinase kinase 4", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 2", "Myotubularin-related protein 6", "N-acetyl-D-glucosamine kinase", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal kinase-like protein", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NAD-dependent protein deacetylase sirtuin-2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 1", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD4-like E3 ubiquitin-protein ligase WWP2", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurofibromin", "Neurolysin, mitochondrial", "Neuropathy target esterase", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Non-structural maintenance of chromosomes element 3 homolog", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear cap-binding protein subunit 2", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor corepressor 1", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin p54", "Nucleoside diphosphate kinase 3", "Nucleoside diphosphate kinase A", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "NudC domain-containing protein 3", "OCIA domain-containing protein 1", "OTU domain-containing protein 7B", "Obg-like ATPase 1", "Occludin", "Opioid growth factor receptor", "Origin recognition complex subunit 3", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PAKB subfamily", "PAX3- and PAX7-binding protein 1", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 3", "PDZ and LIM domain protein 5", "PEK family", "PH-interacting protein", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PITSLRE subfamily", "PKA family", "PKC alpha subfamily", "PKC delta subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal bifunctional enzyme", "Peroxisomal biogenesis factor 19", "Peroxisomal carnitine O-octanoyltransferase", "Peroxisomal leader peptide-processing protease", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal targeting signal 1 receptor", "Persulfide dioxygenase ETHE1, mitochondrial", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 3-kinase regulatory subunit beta", "Phosphatidylinositol 4-kinase alpha", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphatidylserine synthase 2", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylated adapter RNA export protein", "Pirin", "Plakophilin-2", "Plasma membrane calcium-transporting ATPase 1", "Plasma membrane calcium-transporting ATPase 4", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polypeptide N-acetylgalactosaminyltransferase 4", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 17", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor 18", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor CWC22 homolog", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SLU7", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable cysteine--tRNA ligase, mitochondrial", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable helicase with zinc finger domain", "Probable histidine--tRNA ligase, mitochondrial", "Probable leucine--tRNA ligase, mitochondrial", "Probable proline--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Proteasome inhibitor PI31 subunit", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein Hook homolog 1", "Protein LSM14 homolog B", "Protein NDRG1", "Protein NDRG3", "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "Protein PAT1 homolog 1", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SET", "Protein XRP2", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein kinase c alpha type", "Protein kinase c beta type", "Protein kinase c delta type", "Protein lin-28 homolog B", "Protein lin-9 homolog", "Protein methyltransferase", "Protein pelota homolog", "Protein phosphatase", "Protein phosphatase 1F", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein spinster homolog 1", "Protein strawberry notch homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec24D", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog A", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Proto-oncogene c-Rel", "Pseudouridine-5'-phosphatase", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative ATP-dependent RNA helicase DHX57", "Putative heat shock protein HSP 90-beta 4", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal phosphate phosphatase", "Pyridoxine-5'-phosphate oxidase", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RAD53 family", "RAF family", "RIO family", "RIO1 subfamily", "RIO2 subfamily", "RIPK family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA polymerase II subunit A C-terminal domain phosphatase", "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein 7", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab proteins geranylgeranyltransferase component A 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Radixin", "Raf proto-oncogene serine/threonine-protein kinase", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein nGAP", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras GTPase-activating-like protein IQGAP3", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein R-Ras2", "Ras-related protein Ral-A", "Reader", "Receptor", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Rel homology transcription factor", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal dehydrogenase 2", "Retinoblastoma-associated protein", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Rho GDP-dissociation inhibitor 1", "Rho GTPase-activating protein 18", "Rho-associated protein kinase 1", "Rho-associated protein kinase 2", "Rho-related GTP-binding protein RhoG", "Rhomboid domain-containing protein 2", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p25-like protein", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal RNA-processing protein 7 homolog A", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 2 homolog", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "S1 RNA-binding domain-containing protein 1", "SAP30-binding protein", "SCY1 family", "SEC23-interacting protein", "SET domain", "SGK family", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC2 family of hexose and sugar alcohol transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC35 family of nucleotide sugar transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC61 Molybdate transporter family", "SLC63 Sphingosine-phosphate transporters", "SLC7 family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRC family", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sal-like protein 2", "Sarcolemmal membrane-associated protein", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Scm-like with four MBT domains protein 1", "Scy1-like protein 2", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Sentrin-specific protease 3", "Separin", "Septin-11", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine-protein kinase atm", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase atr", "Serine/threonine-protein kinase chk1", "Serine/threonine-protein kinase chk2", "Serine/threonine-protein kinase greatwall", "Serine/threonine-protein kinase mark2", "Serine/threonine-protein kinase mrck beta", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n1", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase pak 4", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase rio1", "Serine/threonine-protein kinase rio2", "Serine/threonine-protein kinase sgk3", "Serine/threonine-protein kinase tao1", "Serine/threonine-protein kinase ulk3", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase vrk2", "Serine/threonine-protein kinase wnk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sialidase-1", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signal-induced proliferation-associated protein 1", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium-dependent HCO3- transporters", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 12 member 9", "Solute carrier family 2, facilitated glucose transporter member 1", "Solute carrier family 25 member 33", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sortilin", "Sorting nexin-1", "Sorting nexin-14", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptojanin-2-binding protein", "Syntaxin-12", "Syntaxin-18", "Syntaxin-3", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "Syntenin-1", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "T-complex protein 11-like protein 1", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TAK1 subfamily", "TAO subfamily", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TNF receptor-associated factor 2", "TOPK family", "TP53-binding protein 1", "TRIO family", "TTK family", "Tapasin", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Terminal uridylyltransferase 4", "Testin", "Testis-specific Y-encoded-like protein 1", "Tetratricopeptide repeat protein 28", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid adenoma-associated protein", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1A", "Trafficking protein particle complex subunit 4", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription factor 20", "Transcription factor SPT20 homolog", "Transcription factor p65", "Transcription initiation factor IIB", "Transcription initiation factor IIE subunit beta", "Transcription initiation factor TFIID subunit 6", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation initiation factor IF-2, mitochondrial", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-2", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Triple functional domain protein", "Trophoblast glycoprotein", "Tropomodulin-1", "Tropomodulin-3", "Tropomyosin alpha-1 chain", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-4A chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-2", "Twinkle protein, mitochondrial", "Type II PI4K subfamily", "Type III PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "Tyrosine-protein kinase yes", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "U6 snRNA-associated Sm-like protein LSm7", "UDP-glucose:glycoprotein glucosyltransferase 1", "ULK family", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog A", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 15", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 34", "Ubiquitin carboxyl-terminal hydrolase 4", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin conjugation factor E4 B", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 5", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like modifier-activating enzyme ATG7", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-Ie", "Unconventional myosin-VI", "Unconventional myosin-Va", "Upstream-binding protein 1", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 45", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuolar protein sorting-associated protein 72 homolog", "Vacuole membrane protein 1", "Very long-chain acyl-CoA synthetase", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WASH complex subunit 5", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 74", "WD repeat-containing protein 82", "WEE family", "WNK family", "Winged helix/forkhead transcription factor", "Wiskott-Aldrich syndrome protein family member 2", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger CCCH domain-containing protein 7B", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 3", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 281", "Zinc finger protein 622", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zinc transporter ZIP14", "Zyxin", "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "mRNA-decapping enzyme 1A", "mRNA-decapping enzyme 1B", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGTPBP1", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALYREF", "AMPD2", "ANAPC1", "ANKS1A", "ANO6", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APOL2", "APP", "ARCN1", "ARFIP1", "ARG2", "ARHGAP18", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "AS3MT", "ASAH1", "ASH2L", "ASNA1", "ASNS", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATG7", "ATIC", "ATL2", "ATL3", "ATM", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATR", "ATXN2L", "AUP1", "AURKA", "AURKB", "B4GALT3", "BAG6", "BAIAP2", "BAX", "BCAP31", "BCAS2", "BCAT1", "BCAT2", "BCKDHB", "BCKDK", "BCLAF1", "BCR", "BECN1", "BLMH", "BLOC1S1", "BLVRA", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD4", "BRIX1", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CBL", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC25C", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CDKN2AIP", "CEBPZ", "CECR2", "CEP170", "CEP250", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHEK1", "CHEK2", "CHERP", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHUK", "CIRBP", "CIT", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLIP1", "CLK3", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT4", "CNOT7", "CNP", "COASY", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CROT", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CWC22", "CYB5B", "CYB5D2", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DDB1", "DDI2", "DDOST", "DDT", "DENR", "DERA", "DERL1", "DERL2", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPH5", "DPM1", "DPP3", "DPP9", "DPYSL2", "DPYSL3", "DPYSL5", "DSC2", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELF2", "ELMO2", "ELMOD2", "ELOB", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "ENO2", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERH", "ERO1A", "ERP29", "ESD", "ESPL1", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXO1", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBE1", "GCAT", "GCFC2", "GCLC", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GID8", "GINS1", "GINS2", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNE", "GNG5", "GNPDA1", "GNS", "GOLGA2", "GOSR1", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSPT1", "GSR", "GSS", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF3C3", "GTF3C5", "GTPBP1", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDAC6", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOOK1", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INTS11", "INTS6", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "ITCH", "ITGB1", "ITPA", "ITPK1", "ITSN2", "IVD", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPCAT4", "LRRC47", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LTN1", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAN1A2", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARK2", "MARS2", "MASTL", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "MED21", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD3", "MFSD5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU2", "MIPEP", "MMS19", "MOCS3", "MORF4L1", "MPC2", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL38", "MRPL39", "MRPL44", "MRPL47", "MRPL9", "MRPS11", "MRPS16", "MRPS18A", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NADK2", "NAE1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCAPD3", "NCBP1", "NCBP2", "NCL", "NCOA5", "NCOR1", "ND1", "NDC80", "NDRG1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB1", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NDUFS8", "NEDD4", "NEDD4L", "NEK9", "NEU1", "NF1", "NHP2", "NIPBL", "NISCH", "NKRF", "NLN", "NME1", "NME3", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGFR", "OLA1", "OPA1", "ORC3", "OTUB1", "OTUD7B", "OXA1L", "OXCT1", "P3H1", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAIP1", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARS2", "PATL1", "PAXBP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDHX", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXP", "PEBP1", "PELO", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGK", "PIK3C2A", "PIK3R2", "PIK3R4", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPO", "PNPT1", "POGZ", "POLD2", "POLDIP3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "PPA1", "PPA2", "PPAT", "PPM1F", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP1CC", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKAA2", "PRKACA", "PRKAG1", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF18", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMF1", "PSPC1", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPRF", "PUDP", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RAF1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RASAL2", "RAVER1", "RB1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBM7", "RBMX", "RCL1", "RCN1", "RCN2", "RDH11", "RDX", "RECQL", "REEP5", "REL", "RELA", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIOK1", "RIOK2", "RIPK1", "RNASEH2A", "RNH1", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "S100A10", "S100A11", "S100A13", "SAE1", "SALL2", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SC5D", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SCYL1", "SCYL2", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETD7", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SGK3", "SHMT1", "SHMT2", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLK", "SLMAP", "SLU7", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMYD3", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX14", "SNX2", "SOAT1", "SOD2", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPNS1", "SPTLC1", "SPTLC2", "SQLE", "SRBD1", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSU72", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK4", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNJ2BP", "TAB1", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TCP11L1", "TDRKH", "TECR", "TES", "TFCP2", "TFIP11", "TFRC", "THADA", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIMM22", "TJP1", "TJP2", "TK1", "TKT", "TM7SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM97", "TMOD1", "TMOD3", "TMPO", "TNPO1", "TNPO2", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TOR1A", "TP53", "TP53BP1", "TPBG", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRAPPC4", "TRIO", "TRMT61A", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSPYL1", "TST", "TSTA3", "TTC28", "TTK", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2L3", "UBE4A", "UBE4B", "UBP1", "UCHL5", "UCK2", "UGGT1", "ULK3", "UNC119", "UNC119B", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP28", "USP34", "USP39", "USP4", "USP47", "USP5", "USP7", "USP8", "UTP11", "UTP14A", "UTP3", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS72", "VRK1", "VRK2", "VRK3", "WARS", "WASF2", "WASHC5", "WDHD1", "WDR1", "WDR33", "WDR4", "WDR74", "WDR82", "WNK1", "WWP2", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YES1", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7A", "ZC3H7B", "ZCCHC11", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM3", "ZMYM4", "ZNF207", "ZNF281", "ZNF598", "ZNF622", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB7", "ABCB8", "ABCD4", "ACADVL", "ALG1", "AMPD2", "AP2M1", "AP3B1", "AP3M1", "APOL2", "ASAH1", "ASNA1", "ATIC", "ATL2", "ATM", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP6V0A1", "ATP6V0A2", "ATP6V1D", "ATR", "AURKA", "B4GALT3", "BAIAP2", "BAX", "BCR", "BLMH", "BUB1", "CALM3", "CAMK2G", "CAPRIN1", "CARM1", "CASP3", "CCNB1", "CCNB2", "CDC42BPB", "CDK1", "CDK4", "CDK5", "CDK9", "CETN2", "CIT", "CLCN7", "CLUH", "COMT", "COX2", "COX7A2", "CPVL", "CSE1L", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CTSA", "CYB5B", "CYB5D2", "CYP51A1", "DERL1", "DHCR24", "DHFR", "DHX29", "DHX37", "DHX38", "DHX57", "DHX8", "DNM2", "DOCK7", "ECE1", "EEF1D", "EIF5", "ERAP1", "ESPL1", "FNTA", "FNTB", "FOXRED1", "GALNT1", "GALNT2", "GALNT4", "GM2A", "GMPS", "GOSR1", "GYG1", "H1FX", "HDAC6", "HDGFL2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HM13", "IDE", "IPO8", "IPO9", "KDELR1", "KDELR3", "KPNA2", "LAMP1", "LAMP2", "LBR", "LETM1", "LGALS3", "LIG1", "LMAN2", "LNPEP", "MAGED1", "MAP2K1", "MAP2K2", "MAP4K4", "MASTL", "MCL1", "MCM2", "MCM3", "MCM4", "MCM6", "MCM7", "MCU", "METTL7B", "MFSD3", "MIA2", "MICU2", "MIPEP", "MPV17L2", "MSMO1", "MTCH1", "MTCH2", "MTOR", "NAMPT", "NAP1L1", "NAP1L4", "ND1", "NDUFA13", "NNT", "NPEPPS", "NT5C2", "NT5C3B", "NT5DC2", "NUCB1", "NUCB2", "OCIAD1", "OXA1L", "P3H1", "PAK2", "PAK4", "PDK3", "PEX14", "PGRMC1", "PGRMC2", "PIGK", "PIP4K2C", "PLA2G15", "PLBD2", "POMGNT2", "PRCP", "PRDX2", "PRKAA2", "PRKAG1", "PRKDC", "PRMT3", "PRMT5", "PTGES2", "PXMP2", "RAPGEF2", "RCN2", "RECQL", "RHBDD2", "RHEB", "RIOK1", "RIPK1", "ROCK1", "RPS6KA1", "RPS6KA3", "SBNO1", "SCARB1", "SCARB2", "SCPEP1", "SDF4", "SDHB", "SEC11A", "SEC24B", "SFXN1", "SFXN2", "SIRT2", "SLC12A2", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC2A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC4A7", "SLC7A1", "SMARCA1", "SMARCAD1", "SORT1", "SPNS1", "SQLE", "SSR1", "STK4", "STT3A", "STX18", "STX3", "STX5", "STX7", "SURF4", "SYNJ2BP", "TAOK1", "TAP1", "TAP2", "TBC1D10B", "TBC1D9B", "TIMM22", "TM7SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED7", 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0000000000000000000000000000000000000000..037cd71464bffd7d17e9e1dde7bde635705e34f8 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6bc124515fd2fba9175320f2a152a7738127c51bea9bd8f4456c4d4256aeffa2 +size 132262 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..cef369df305c654a1f7a1da2916377f1322e87d1 --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:dad9bd83362cc05c7355fad197117c97c99eb7b6f633939b092982838d31780a +size 132723 diff --git a/pharos_protein_category/basic/plot_2.png b/pharos_protein_category/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..e2df40fbeeef846e0f94729ac7593cf3c52c150f --- /dev/null +++ b/pharos_protein_category/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d41a374e8affafec38f2ac4da5cfcc2f52a32338b6912eafb79e821ee176d135 +size 134431 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1fc47cb63a8823c1c1a2c42468d36bccdb0503f8 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:16deeed30e4ade8162532d25128b357e572481695e16a55ad93eabb97d3fc6fe +size 78082 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6efb410d78d11fc04bb4fb45c702ab3b97001226 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tdark 70 350 2.23335161281937 0.025525766400789 74.3131067961165 324.373786407767 0.5859664552431031 0.6577158703271868 20.515717939687796 49.369088361677456 1.229854636263473 0.4013924214985833 0.744208675778704 0.7189670361809628 0.8743607948238183 0.9976359653801818 0.9999974700827082 +Tclin 22 87 2.1369442228314925 0.0326025285400504 19.366504854368937 86.39077669902913 0.9399778874953114 0.4805096456956057 6.659845213621253 7.009024167820235 0.9745051203556824 0.3806460486794667 0.1030392212462666 0.291752103140925 0.0596580279202176 0.0404714444021463 0.0004201052842794 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ee947376653b2183845fabbf71a70ec987a88ac6 --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 857.25 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..1aa83ee98bfba8e7db9df22202a7d1f095ac1e59 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3189fb350ae6005a3c479c8ba6065890720a6423 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tdark 0.3424457878751442 2.23335161281937 0.025525766400789 0.0982597793228959 0.0652050570801008 350 Q6IAN0,Q9HD45,Q9Y3B3,Q7Z4Q2,Q969T7,Q8WVC6,Q96IX5,P14406,Q9HD20,Q69YU5,Q5HYI8,L0R6Q1,Q3B7T1,Q96S82,Q9Y2G8,O95302,Q9BWH6,Q96SK2,Q8N4H5,O60830,O75964,Q9BVK6,Q9NUD5,Q9NXF7,Q9H4I3,Q9NR77,Q92564,A8MXV4,Q5VW38,Q8IXU6,Q9Y5M8,Q9NUQ9,Q86YN1,Q96EX1,Q96ES6,Q9NPR9,O43731,P83731,Q9BWH2,Q96SY0,Q8WUJ1,Q9NRY5,A0AVF1,Q9H857,Q96DB5,O94919,Q658Y4,Q8NBN3,Q96CN7,Q6ZXV5,Q15629,O75071,Q9BSH5,Q9HC38,O75935,Q96NB2,A3KN83,Q9H1E5,Q9H1I8,Q6ZU35,Q3SXM5,Q9Y6X3,Q7Z2T5,Q6UW02,Q9NPL8,Q9Y6J9,Q9NPA0,Q96LJ7,Q9NX00,Q66K14 70 +Tclin 0.4436754099177237 2.1369442228314925 0.0326025285400504 0.1241700513009754 0.0652050570801008 87 Q9P032,P55011,P06280,P38435,Q9P0J0,Q99720,O43676,Q9UGN5,Q9UBN7,P0DP25,P00374,P49721,Q86Y39,P21964,P04818,P03886,Q9Y6M9,P28074,P10253,P42345,P28340,Q07864 22 +Tchem 0.2983387709745005 1.301492141541522 0.1930900526647287 0.5760640198865494 0.2574534035529717 354 P55786,P30519,P54646,P42858,P43490,P30536,P45880,O60725,Q9UIQ6,Q16850,P09601,P07099,P51812,P31939,Q5BJF2,Q13510,P42892,Q02818,P16278,Q9H7Z7,P42785,P48449,Q9H773,P23786,O95470,P04062,Q8WTV0,Q13126,P49356,Q15418,Q9NZ45,Q9H7B4,P05067,O60502,Q13535,P78417,P52789,Q8TBX8,P10619,Q03164,P37268,Q13432 42 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..dabf3754806c16aef24d97d3331a65be1b37a2a6 --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAGAB", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADO", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEH", "APEX1", "API5", "APIP", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL15", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARL8B", "ARMC1", "ARMC10", "ARMC6", "ARMC8", "ARMC9", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "AS3MT", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATR", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT1", "BCAT2", "BCCIP", "BCKDHB", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BECN1", "BEND3", "BICD2", "BIRC6", "BLM", "BLMH", "BLOC1S1", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C21orf59", "C2CD2L", "C2CD5", "C2orf49", "C3orf58", "C5orf51", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CEP170", "CEP250", "CEP290", "CEP44", "CEP55", "CEP97", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTF8", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT4", "CNOT7", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG5", "COG7", "COG8", "COIL", "COLGALT1", "COMMD2", "COMMD7", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF15", "DCAF16", "DCAF7", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENND5B", "DENR", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSE", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFHD2", "EFL1", "EFR3A", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "ENSA", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM105A", "FAM114A2", "FAM120A", "FAM120B", "FAM126A", "FAM129B", "FAM136A", "FAM162A", "FAM208A", "FAM20B", "FAM213A", "FAM49B", "FAM50A", "FAM83D", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXL18", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FLYWCH1", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN6", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GID8", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR180", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTCD", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP6", "GTPBP8", "GTSE1", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK1", "HP1BP3", "HPF1", "HPRT1", "HPS5", "HS1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90AB4P", "HSP90B1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS4", "INTS6", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRGQ", "IRS4", "ISCA2", "ISG20L2", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1211", "KIAA1468", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT4", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC14", "LRRC40", "LRRC41", "LRRC47", "LRRC57", "LRRC59", "LRRC8A", "LRRFIP1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCRS1", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL13", "METTL25", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOCS2", "MOCS3", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDZ", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL50", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NET1", "NEU1", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OTULIN", "OXA1L", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAWR", "PAXBP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCNT", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEBP1", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHLDB2", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLEKHA7", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "POMP", "PON2", "POP1", "POR", "POU2F1", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPFIBP1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REL", "RELA", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SACS", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SH3RF1", "SHCBP1", "SHMT1", "SHMT2", "SHPRH", "SHTN1", "SIGMAR1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SLU7", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMIM12", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SMYD4", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPR", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRA1", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSNA1", "SSR1", "SSR3", "SSR4", "SSRP1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TAP1", "TAP2", "TAPBP", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TCP11L1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TENM3", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THNSL1", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TM7SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM160", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM33", "TMEM43", "TMEM87A", "TMEM97", "TMLHE", "TMOD1", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC13", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBL7", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIPAS39", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS28", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VPS72", "VRK1", "VRK2", "VRK3", "WAPL", "WARS", "WASF2", "WASHC3", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR35", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR47", "WDR48", "WDR5", "WDR6", "WDR61", "WDR62", "WDR74", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIPI2", "WLS", "WNK1", "WRAP53", "WRAP73", "WTAP", "WWP2", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO6", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YES1", "YKT6", "YLPM1", "YME1L1", "YPEL5", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZFR", "ZFYVE16", "ZMAT2", "ZMPSTE24", "ZMYM2", "ZMYM3", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", 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0.393016134031976 0.0042226323683531 0.0597604037758126 0.0075904072731156 0.0136037852653257 0.0018139393434046 +Antiport 4 5 2.6807485386980923 0.0073457692569371 3.2063106796116503 7.097087378640777 0.8539962634551548 0.3166005193161004 2.0440914093762896 1.1428508308135348 1.2051823486844502 0.2998011899649158 1.0 1.0 1.0 0.01180448121602 0.0022722304352638 +Translocation 8 48 2.5732992187417474 0.0100734076154496 12.434466019417476 47.86165048543689 1.1297087783550883 0.3515144245437065 6.687771513864753 3.601211391947168 1.550426642680832 0.3811939235350816 2.8871079361945836e-05 0.0508992589190798 7.389910731518841e-05 6.954749025761443e-05 0.0008497123392072 +Electron transport 14 46 2.5593774940444898 0.0104859806752075 14.983009708737864 45.592233009708735 1.1180311721330871 0.3315827540150002 5.69510117113123 4.184313965655804 1.5984402393879058 0.3574888993156041 0.0444225207934893 0.0817843887077026 0.0023748989920053 3.597736784406734e-06 1.6853307473296484e-07 +Steroid metabolism 9 28 2.463620360790597 0.0137541707313124 7.703883495145631 26.439320388349515 1.128083592407629 0.3052190273048834 3.279782799169419 3.1412859163137186 1.216134343451914 0.3162944576553002 0.0737029175928528 0.237457799625543 0.0978881295505725 4.818233124362865e-05 1.0143939354860572e-05 +Lipid transport 6 24 2.4276930211214007 0.0151951987307188 5.140776699029126 21.796116504854368 0.7022879686929654 0.35525802853007 2.5598823127228028 3.5727100026626353 1.209238263022456 0.2984698606617377 0.0158173757335074 0.0039147102095996 0.0244837275894334 0.0203556588144228 0.0380767748489745 +Respiratory chain 10 33 2.412874680305406 0.0158272604645521 10.895631067961164 31.91990291262136 1.1075564231308468 0.3095707256998049 4.44287149555612 3.6670789399383112 1.4970961025113558 0.3356221172021658 0.0880733344897457 0.2597451867723493 0.0027541417385927 1.4349197272756235e-05 5.72508037374203e-06 +Cholesterol metabolism 8 24 2.349774918491994 0.0187847663824003 7.111650485436893 23.79854368932039 1.169709264926864 0.2871268807807383 2.8890755390042298 2.7173834172675666 1.205315163774447 0.3061468445376054 0.0517352073763297 0.1988423464133734 0.0693457394610891 9.297701577536192e-05 4.717474112626933e-05 +Sterol metabolism 8 26 2.3269342087611893 0.0199687671550312 7.606796116504855 25.203883495145632 1.1785484151208083 0.2872927387372206 3.1377365577760563 3.096691699470945 1.2399567569518877 0.3064799172119154 0.0580399290913614 0.2106238865633207 0.0775813155228076 0.0001418153943193 1.4448444286151774e-05 +Calcium transport 4 6 2.3222446095437865 0.0202197682057332 3.7305825242718447 8.240291262135923 0.5020754788348019 0.3462849026834517 2.2148520410126937 1.861210565609195 1.3394131933179945 0.3209721672484884 1.0 1.0 1.0 0.5970702236031354 0.1040239469578102 +Lipid metabolism 28 135 2.253088847821707 0.0242535474973417 32.65533980582524 126.3009708737864 0.0122638234126047 0.3570579745388888 13.120525890444084 12.789813112229345 1.8284441878622113 0.3670562446523409 0.0032955136619325 0.4436393759474107 0.0006759353496621 1.1336020027390224e-09 2.680860394636151e-09 +Unfolded protein response 1 8 2.205291421752752 0.0274336514126405 2.3398058252427183 8.633495145631068 0.5480385300300274 0.4400154077997862 1.5814666785930227 1.2881628437865913 0.9699422804803254 0.3025490427097851 0.2241232989350378 1.0 0.2590666885683055 0.1724444479617574 0.450369534817547 +Steroid biosynthesis 10 23 2.190703064765804 0.0284732871747508 6.351941747572815 21.094660194174757 1.1936032046421512 0.306057763510231 2.838692628881621 2.6297902443336034 1.071011617665077 0.2981933340003868 0.2177365324780222 0.1373006943976843 0.2518545844225215 5.686128654661118e-06 7.76783450774729e-08 +Amino-acid transport 3 6 2.098272492101928 0.0358810810473495 3.063106796116505 7.016990291262136 0.9299828460487652 0.271909550896337 1.9171930478617292 1.3907470472448622 1.1684874391815692 0.271335812648974 1.0 1.0 1.0 0.5094216597603356 0.1659016353191164 +Sensory transduction 1 7 2.0743465829552727 0.0380471344542314 2.3907766990291264 6.065533980582524 1.0901502088613606 0.2182341455376904 1.4245463862041683 1.4083924790550797 1.1790733646497054 0.2382326050755758 0.2177365324780222 1.0 0.2518545844225215 0.1637924032376012 0.4336067804253886 +Vision 1 7 2.0743465829552727 0.0380471344542314 2.3470873786407767 5.992718446601942 1.08525596348634 0.2199144433248849 1.3876767838522928 1.281854462283163 1.178949427510656 0.2385050933787637 0.1850152793775121 1.0 0.2147385524083838 0.1219531221716571 0.3460963812051635 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..fa640e0cb365e0ddf52d20677f66f1d5140d597f --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 170, + "title": "Average number of proteins per term", + "value": 32.49411764705882 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bccf3767fa1b2ffdf40c24934c44fc045fe38583 --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8aa62707a62d112ec39d029da474fc0aed49a6e8 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,59 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transport 0.4866862680612731 5.709984562826775 1.1298642145253042e-08 1.9207673310381267e-06 1.920769164863017e-06 509 P55060,Q9NS69,P24390,P53985,O75165,O60831,O43169,Q9H9B4,P45880,Q9BQE5,A6NIH7,Q2M389,P21796,O00461,Q99720,O43676,Q16134,Q8N4H5,O60830,P06576,O75964,Q9UM00,Q8TB61,O95197,Q14849,Q9C0H2,O75381,Q9Y5X2,Q9UBX3,Q14728,Q99595,Q96ES6,P43034,O43731,P20337,Q9Y584,P23786,P41208,P03886,Q13505,O14949,Q9Y282,Q03518,Q15629,Q9UDW1,Q9Y487,Q70HW3,O15118,Q9H1E5,Q9BTX1,Q9P2W9,P22695,Q15907,Q9H2D1,P46379,O14925,Q13432,Q9Y3B3,Q93050,Q9HD20,O43396,Q9H2V7,Q9P0J0,O43772,O95202,P52292,O15127,Q9BSK2,Q9Y6C9,Q96P70,Q8IXU6,P24539,P12235,Q86Y39,P47985,Q03519,Q9Y5L4,Q969Q5,Q8N5M9,P00403,Q9BUN8,P12236,P30825,O14678,Q15363,Q9NZJ7,Q6P4A7,Q9NR31,P16615,O95249,Q13277,Q96CU9,Q9Y619,Q9Y5X3,Q9H4A6,Q9BUR5,Q9H2U1,P20020,Q6DKK2,P21912,Q96RL7,Q9Y277,Q9Y6B6,Q13190,P49755,Q99584,Q9BXW6,A0AVF1,P51798,O15397,Q96NB2,Q15388,Q96D46,Q96KP1,Q8NE01,Q9NUT2,P55011,O95864,Q9BQT8,Q15043,Q9C0E2,Q9H3N1,Q9Y5J9,Q9BVK6,Q8NE86,Q15904,Q96QU8,P08183,O43681,P61020,P56385,Q92973,Q7Z3C6,Q13409,Q9Y6M9,Q7L5D6,P18085,P61970,Q12907,P51970,O00203,O43808,P05141 143 +Peptide transport 0.9431155192532056 3.661310221337444 0.000250928699873 0.0417659616246471 0.0025003175770506 2 Q03518 1 +DNA excision 0.8849915623385181 3.1735315510686406 0.0015059653286886 0.2260183191463993 0.0082249702049586 3 Q9UQ84 1 +Protein transport 0.4162044703810673 3.0917111993725817 0.0019900635929548 0.2872666331846317 0.0102518427515855 274 P55060,O95249,Q9NS69,P24390,Q9Y3B3,O75165,O60831,Q9HD20,Q9Y5X3,Q2M389,A6NIH7,Q9H4A6,P52292,Q8N4H5,O60830,Q9C0E2,O15127,Q96RL7,Q9Y5J9,Q9BVK6,Q9Y6B6,O75381,Q9Y5X2,Q96P70,Q96QU8,Q99595,P20337,O43731,P49755,Q99584,Q9Y584,P61020,A0AVF1,P41208,Q03519,Q13505,Q9Y5L4,Q92973,Q7Z3C6,Q969Q5,Q8N5M9,O15397,Q03518,Q9BUN8,Q15629,P18085,P61970,Q15388,Q96D46,Q9BTX1,Q9P2W9,Q12907,O00203,Q15907,Q15363,Q96KP1,Q9NR31,O14925,Q13432 59 +Prostaglandin biosynthesis 0.7922987164527251 2.9500196743928875 0.0031775369439259 0.417858262584362 0.0154337508704975 2 Q9H7Z7 1 +Sphingolipid metabolism 0.8790380569470594 2.7707584009825115 0.0055925905819818 0.6145750949258818 0.0227051106293148 9 O95470,P04062,P17900,P07602,Q06136 5 +Ion transport 0.5591031656404902 2.7545875296001645 0.0058766168687638 0.6328452516343432 0.0227051106293148 49 Q9NUT2,Q93050,P55011,P45880,P21796,P20020,O95202,P06576,Q15043,O75964,Q9UM00,Q9Y277,Q8NE86,Q15904,Q9C0H2,P24539,P56385,Q4KMQ2,P51798,Q9Y6M7,Q9Y487,P16615,Q8NE01 23 +ER-Golgi transport 0.5473006882997249 2.7088631248875834 0.006751418626419 0.683879919015986 0.0244200248189624 51 O95249,P24390,Q9Y6B6,O95197,Q9P2W9,Q15363,Q9Y282,Q9NR31,O43731 9 +Antiport 0.8548905109488905 2.6807485386980923 0.0073457692569371 0.7144648063930059 0.0249756154735864 5 P12235,P12236,O95202,P51798 4 +Translocation 0.5406560573535666 2.5732992187417474 0.0100734076154496 0.821141968969366 0.0323109300872912 48 P41208,Q9NS69,Q9BTX1,O60830,Q99595,Q15629,O14925,Q9Y584 8 +Electron transport 0.54459709457832 2.5593774940444898 0.0104859806752075 0.8333782176712994 0.0330114206441719 46 Q9H1E5,Q96CU9,O43169,P03886,P22695,Q9UDW1,O43396,O14949,Q9P0J0,P00403,Q6DKK2,O43676,Q86Y39,P47985 14 +Steroid metabolism 0.6003001617621264 2.4636203607905975 0.0137541707313124 0.9050531550289418 0.0425128913513294 28 P54646,Q15392,O15118,O76062,P04062,Q15800,Q06520,Q16850,P37268 9 +Lipid transport 0.6299493744937066 2.4276930211214007 0.0151951987307188 0.9259497148349124 0.0453190137582842 24 O15118,Q14849,Q9BQE5,Q9BUR5,Q9H2V7,Q99720 6 +Respiratory chain 0.5734820247693014 2.412874680305406 0.0158272604645521 0.9336063815508224 0.0463902461892046 33 Q96CU9,P03886,P22695,Q9UDW1,O14949,Q9P0J0,P00403,O43676,Q86Y39,P47985 10 +Cholesterol metabolism 0.6179799712042112 2.349774918491994 0.0187847663824003 0.9601958860969242 0.0523509882788206 24 P54646,Q15392,O15118,O76062,P04062,Q15800,Q16850,P37268 8 +Sterol metabolism 0.5980557232774656 2.3269342087611893 0.0199687671550312 0.9675820302435594 0.0545612792853119 26 P54646,Q15392,O15118,O76062,P04062,Q15800,Q16850,P37268 8 +Calcium transport 0.8067039392437233 2.3222446095437865 0.0202197682057332 0.9689633829166736 0.0545612792853119 6 P16615,O95202,P20020,Q8NE86 4 +Coenzyme A biosynthesis 0.6586931155192577 2.2623251246366576 0.0236773232319729 0.9829833513239196 0.0619253069143907 2 Q13057 1 +Lipid metabolism 0.407479088227751 2.253088847821707 0.0242535474973417 0.9846082936037588 0.0624712587052742 135 Q15392,Q8N2A8,Q16850,Q13510,O76062,Q9NPH0,Q9H7Z7,Q06520,P48449,Q96G23,P23786,O95470,P04062,A1L0T0,Q53GQ0,P07602,O00116,P51648,Q8NCC3,Q06136,O15118,Q15800,P17900,P49748,Q9NUQ2,P27544,Q8NHP8,P37268 28 +Unfolded protein response 0.7657932436993509 2.205291421752752 0.0274336514126405 0.9911636976691228 0.066624582002127 8 Q15629 1 +Steroid biosynthesis 0.6014140998821927 2.190703064765804 0.0284732871747508 0.9926327250603352 0.0681754763339104 23 P54646,Q15392,O76062,Q15800,Q53GQ0,Q9UBM7,Q16850,P48449,Q14739,P37268 10 +Glycogen biosynthesis 0.717131770640351 2.176846636139378 0.0294920121131083 0.99383618744416 0.0696339174892836 4 P35573,P46976 2 +Amino-acid transport 0.7579009163403131 2.098272492101928 0.0358810810473495 0.997994591407034 0.083558681891088 6 Q96NB2,P30825,Q6P4A7 3 +Sensory transduction 0.7457010885906022 2.0743465829552727 0.0380471344542314 0.9986318152137872 0.0851054323318335 7 P50897 1 +Vision 0.7457010885906022 2.0743465829552727 0.0380471344542314 0.9986318152137872 0.0851054323318335 7 P50897 1 +Sterol biosynthesis 0.6120778642730632 1.950255507538847 0.0511456728356412 0.9998669783825284 0.1100603086336582 17 P54646,Q15392,O76062,Q15800,Q9UBM7,Q16850,Q14739,P37268 8 +Cholesterol biosynthesis 0.6244549021755516 1.923521473502409 0.0544145923493337 0.999926017422336 0.1142034654245276 15 P54646,Q15392,O76062,Q15800,Q16850,P37268 6 +Lipid biosynthesis 0.4481739906619194 1.877765616615075 0.0604132358532254 0.9999749232442744 0.1222648820839086 55 P54646,Q15392,Q9P035,O95864,Q16850,Q9NWU1,O76062,Q9H7Z7,Q9UBM7,P48449,P48651,Q8NF37,Q14739,Q96G23,Q96N66,Q53GQ0,O00116,Q8WVX9,O75845,P49327,Q15800,Q9NUQ2,P27544,O00767,P37268,P54619 26 +Oogenesis 0.6500291885580777 1.84088564404507 0.0656383186080016 0.9999902825275632 0.1253765636332615 4 Q9Y5A9,Q9H6S0,O60879 3 +Glyoxylate bypass 0.5808051341890417 1.834425805833712 0.0665908118865603 0.9999918294334622 0.125782644674614 2 O75874 1 +Prostaglandin metabolism 0.601871345678591 1.7666995782958552 0.0772785540445295 0.9999988465348244 0.1419047679524798 3 Q9H7Z7 1 +Apoptosis 0.3738581331292883 1.7646045193590134 0.0776302554092978 0.999998918918818 0.1419047679524798 132 P42858,Q9UHX1,P09601,P21796,Q9P0J0,P61289,O95197,Q96KA5,O95470,Q9BXK5,O14737,Q96A26,P12236,P05067,Q9UDX5,Q9UBK9,Q9NZJ7,Q03164,P46379 19 +Potassium transport 0.6177498732008346 1.6752284576347336 0.0938894160926133 0.9999999474219406 0.1680126393236239 4 Q9NUT2 1 +Biomineralization 0.5405484247374714 1.6059892898542971 0.1082762631904947 0.9999999965393662 0.1917392160665011 2 Q6P4Q7 1 +Adaptive immunity 0.5486652611043231 1.5187483155454895 0.128825859948612 0.9999999999342576 0.2234734305231026 16 Q9NZ08,P09429,Q03519,Q03518 4 +Branched-chain amino acid biosynthesis 0.5145857642940577 1.456501983874542 0.1452539015982679 0.9999999999974158 0.2420898359971131 2 O15382 1 +Sodium transport 0.5710487809036382 1.4316574706756415 0.1522418734359887 0.99999999999936 0.2464868427058864 4 P55011,Q9Y6M7 2 +Lipid degradation 0.5080643079523808 1.4001527510649443 0.1614675812987205 0.9999999999999004 0.2565372786989017 19 Q8N2A8,Q8NCC3,Q06520,Q8NHP8 4 +Polyamine biosynthesis 0.5014585764294142 1.380414951092378 0.1674589193875311 0.9999999999999706 0.263592743480373 2 P52788 1 +Hydrogen ion transport 0.4831090271448243 1.2364377523442045 0.2162958904431744 1.0 0.3312639763544113 19 O75964,P56385,Q93050,Q15904,P24539,Q9Y487,P06576 7 +Nucleotide metabolism 0.5207034702220615 1.1064951421407292 0.2685122654916854 1.0 0.4075632601213081 12 Q969T7 1 +Chemotaxis 0.4993852384980401 1.052911930334972 0.2923813577081198 1.0 0.4360072878103541 4 P09429 1 +ATP synthesis 0.5277630608266274 0.9977739410963696 0.3183889890801756 1.0 0.4654728901296359 7 O75964,P56385 2 +Meiosis 0.4498945552965789 0.9782001913140148 0.3279753218686894 1.0 0.4654728901296359 18 Q9UQ84,Q8N2A8,Q9H6S0,Q8IXJ6 4 +Stress response 0.3972471998643399 0.9442469013964604 0.345043493043391 1.0 0.484771849730384 28 O95197,P51812,Q15418 3 +Symport 0.5142651800366271 0.9134460908776256 0.3610079740919167 1.0 0.4989541105335435 6 P55011,P53985 2 +Phospholipid metabolism 0.4347268098467439 0.6809468031710624 0.4959051516049868 1.0 0.615356757466042 13 Q9NUQ2,Q96N66,P48651,Q9NPH0 4 +Sodium/potassium transport 0.3599766627771251 0.5714315348065898 0.5677071579300041 1.0 0.6720300257214834 2 P05023 1 +Ubiquinone biosynthesis 0.3793405310767522 0.5550943422055501 0.578830132484524 1.0 0.6786284311887523 3 Q8NI60,Q5T2R2 2 +GPI-anchor biosynthesis 0.4037884437110514 0.4777975400336396 0.6327943121999973 1.0 0.7368152950273941 5 Q92643,O43292 2 +Autophagy 0.3254842727484605 0.4452351909844796 0.6561497977661246 1.0 0.7588126912941576 34 P54646,P09429,P13473,Q7Z3C6,Q9UBN7,Q969Q5,Q96GC9,Q96DM3 8 +Purine biosynthesis 0.4016725419653396 0.4113634202402879 0.6808060722621296 1.0 0.7759701316275714 9 P31939 1 +Immunity 0.2920098193779903 0.337191268868527 0.7359727187304186 1.0 0.8231273827905997 84 P09429,Q03519,P01889,Q9NUD5,Q9UQ84,Q92974,P78527,Q8IV08,Q8N5M9,Q9H2U1,Q03518,P46379,Q9NZ08 13 +Nucleotide biosynthesis 0.3867781388045066 0.3301555518164641 0.7412824299727871 1.0 0.8236471444142079 6 P04818,P32321 2 +Wnt signaling pathway 0.3172679009847872 0.2784636331990077 0.7806564779372014 1.0 0.8530201730501954 25 P54646,P48729,Q5T9L3 3 +Cilium biogenesis/degradation 0.2998649714873267 0.2203986360344211 0.8255607075846667 1.0 0.8939192375120595 28 A6NIH7 1 +Exocytosis 0.3134738925482675 0.1567827152432986 0.8754160956109149 1.0 0.9359794732946888 17 Q9UPT5,Q96KP1,Q96A65,O60645,Q9BRK5 5 +Inflammatory response 0.2951222496907907 0.026023144691459 0.9792388779062828 1.0 1.0 10 Q8IV08,P09429 2 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cf86939399ff70927e69911eca269f8d8f51a6a5 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Bile acid catabolism", "Biological rhythms", "Biomineralization", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Carnitine biosynthesis", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Melanin biosynthesis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyridoxine biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAGAB", "AAR2", "AARS", "AARS2", "AARSD1", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF3", "ABHD12", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP8", "AKAP8L", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALDOC", "ALKBH5", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEX1", "API5", "APIP", "APOL2", "APOO", "APP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARG2", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARL8A", "ARL8B", "ARMC10", "ARMC9", "ARMT1", "ARRB2", "ARVCF", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATAD5", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATR", "AUP1", "AURKA", "AURKB", "BABAM1", "BABAM2", "BAG3", "BAG6", "BANF1", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT1", "BCAT2", "BCCIP", "BCL2L13", "BCLAF1", "BECN1", "BEND3", "BICD2", "BIRC6", "BLM", "BMS1", "BOP1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C2CD2L", "C2CD5", "CACYBP", "CAD", "CALCOCO1", "CAMK1", "CAMK2G", "CAND1", "CAND2", "CANX", "CAPRIN1", "CARM1", "CARS", "CARS2", "CASP3", "CASP7", "CBL", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK9", "CDKAL1", "CEBPZ", "CELF1", "CELF2", "CENPF", "CENPU", "CENPV", "CEP250", "CEP290", "CEP55", "CEP97", "CERS1", "CERS2", "CETN2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHID1", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHTF18", "CHTF8", "CIAPIN1", "CIRBP", "CISD2", "CIT", "CKAP2", "CKAP5", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLPTM1", "CLPTM1L", "CLSTN3", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT4", "CNOT7", "COASY", "COG5", "COG7", "COG8", "COMMD2", "COMMD7", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPS7A", "COPS7B", "COPZ1", "COQ8A", "CORO7", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CREBBP", "CRNKL1", "CROT", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC22", "CXADR", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF15", "DCAF16", "DCAF7", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN3", "DCUN1D1", "DCXR", "DDA1", "DDB1", "DDRGK1", "DDT", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLST", "DMAP1", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPY30", "DPYSL2", "DR1", "DSC2", "DSG2", "DST", "DTL", "DTYMK", "DUS2", "DUS3L", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "ECT2", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELF2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "ENO2", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPN1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESPL1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOC8", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FAM50A", "FAM83D", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXL18", "FBXO22", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP15", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FOXRED1", "FRYL", "FSD1", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALE", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCC2", "GCFC2", "GCLC", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GEMIN6", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GHITM", "GID8", "GINS1", "GINS2", "GINS3", "GINS4", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPHN", "GPI", "GPKOW", "GPR89B", "GRB2", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSS", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP10", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H2AFX", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HERC2", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK1", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKB", "ILF2", "ILF3", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INPPL1", "INTS3", "INTS7", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRAK1", "IRF2BP1", "ISG20L2", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITPA", "ITSN2", "IVD", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA1468", "KIDINS220", "KIF11", "KIF1B", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIFBP", "KIFC1", "KIN", "KLC1", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPCAT4", "LRP1", "LRPPRC", "LRRC41", "LRRC8A", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED1", "MAGT1", "MAP1S", "MAP3K7", "MAPK1", "MAPK3", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCRS1", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MESD", "MFAP1", "MFGE8", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MIA3", "MICAL3", "MICALL1", "MID1", "MIF", "MINDY3", "MKI67", "MLEC", "MMS19", "MOCS1", "MOCS3", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDZ", "MPHOSPH10", "MPHOSPH6", "MRE11", "MRGBP", "MRPL58", "MRPS27", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTERF3", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO5A", "MYO6", "NAA15", "NAE1", "NAF1", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCKAP1", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NES", "NEU1", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NMD3", "NME1", "NME3", "NME7", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT16", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGFR", "OGT", "OPA1", "ORC3", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OTULIN", "OXSM", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PANK4", "PAPOLA", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PAWR", "PAXBP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDK1", "PDK3", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF2", "PHF6", "PHGDH", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIR", "PISD", "PITPNB", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLIN3", "PLK1", "PLRG1", "PMF1", "PMVK", "PNKP", "PNN", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POP1", "POU2F1", "PPAT", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R8", "PPP2R1A", "PPP4R2", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKAG1", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT5", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RANGRF", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBM10", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM5", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCOR1", "REL", "RELA", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMC1", "RMDN3", "RMND1", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPF2", "RPL10", "RPL13A", "RPP14", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RTCB", "RTF1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SC5D", "SCAF1", "SCAF11", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SCYL1", "SDAD1", "SDE2", "SDF4", "SDHA", "SDHB", "SEC16A", "SEC22B", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEL1L", "SELENBP1", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3RF1", "SHMT1", "SHMT2", "SHPRH", "SIGMAR1", "SIN3A", "SIRT1", "SIRT2", "SKA3", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SLU7", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SON", "SORT1", "SPAG5", "SPATA5", "SPC24", "SPDL1", "SPECC1L", "SPEN", "SPNS1", "SPTLC1", "SPTLC2", "SRA1", "SRCAP", "SREK1", "SRM", "SRPK1", "SRPK2", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "TACC3", "TAF6", "TAF6L", "TALDO1", "TAMM41", "TAOK1", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TARSL2", "TBCB", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TDP2", "TDRKH", "TECR", "TEFM", "TENM3", "TERF2", "TERF2IP", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TK1", "TLN1", "TM7SF2", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM214", "TMLHE", "TMX1", "TMX4", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOM1", "TOM1L2", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOPBP1", "TP53", "TP53BP1", "TPI1", "TPR", "TPRKB", "TPX2", "TRA2A", "TRA2B", "TRAF2", "TRAM1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT11", "TRMT1L", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSNAX", "TSR1", "TTC19", "TTC26", "TTC28", "TTC4", "TTLL12", "TTYH3", "TUBB2B", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBL5", "UBL7", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UHRF1", "ULK3", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UXT", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIPAS39", "VIRMA", "VMP1", "VPS13A", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS28", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VPS72", "VRK1", "VRK2", "WAPL", "WARS", "WASF2", "WASHC3", "WASHC4", "WASHC5", "WBP11", "WDR12", "WDR33", "WDR35", "WDR36", "WDR4", "WDR41", "WDR43", "WDR48", "WDR5", "WDR6", "WDR61", "WDR62", "WDR75", "WIPI2", "WLS", "WRAP53", "WRAP73", "WTAP", "WWP2", "XAB2", "XPO1", "XPO4", "XPO5", "XPO6", "XPO7", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "ZC3H11A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZCRB1", "ZMAT2", "ZMYM2", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCB8", "ABCD4", "ACADVL", "ACP6", "AGL", "AGPAT5", "AGPS", "ALDH3A2", "ANO6", "AP3B1", "APOL2", "APOO", "APP", "ARF4", "ARHGEF2", "ASAH1", "ASNA1", "ATG9A", "ATIC", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "BAG6", "BCAT2", "BCL2L13", "CERS1", "CERS2", "CETN2", "CLCN7", "CLPTM1L", "CNNM3", "CNNM4", "COASY", "COQ8A", "COX2", "CPT2", "CSE1L", "CSNK1A1", "CYB5B", "CYP51A1", "DCTD", "DERL1", "DHCR24", "DHCR7", "DHX36", "DIAPH2", "DNAJC13", "DYNC1I2", "ERAP1", "ERGIC3", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC7", "FADS2", "FAM162A", "FAR1", "FASN", "FDFT1", "FOXRED1", "GBA", "GET4", "GM2A", "GOLIM4", "GOLPH3", "GOSR1", "GPAA1", "GYG1", "HACD3", "HDAC6", "HLA-B", "HMGB1", "HMOX1", "HSD17B12", "HTT", "IDH1", "ILVBL", "IPO8", "IPO9", "JAGN1", "KDELR1", "KDELR3", "KDSR", "KMT2A", "KPNA2", "LAMP2", "LBR", "LETM1", "LMAN2", "LPCAT1", "LSS", "MBOAT7", "MCU", "MFSD10", "MFSD3", "MSMO1", "MTCH1", "MTCH2", "MTFP1", "MTX1", "ND1", "NDC1", "NDUFA11", "NDUFA13", "NDUFA8", "NDUFB3", "NDUFB9", "NMD3", "NPC1", "NT5C3B", "NUTF2", "OSBPL1A", "OXSM", "PAFAH1B1", "PDCD5", "PDSS1", "PEX14", "PIGK", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PPT1", "PRAF2", "PRKAA2", "PRKAG1", "PRKDC", "PSAP", "PSME3", "PTDSS1", "PTGES2", "PUF60", "RAB11B", "RAB24", "RAB3B", "RAB5B", "RMC1", "RPS6KA1", "RPS6KA3", "RTN3", "S100A13", "SAR1A", "SAR1B", "SC5D", "SCAMP2", "SCD", "SDF4", "SDHB", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SIGMAR1", "SIRT2", "SLC12A2", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC35B2", "SLC35F2", "SLC39A14", "SLC4A7", "SLC7A1", "SMS", "SNX5", 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pval_hit pval_50 pval_100 pval_250 pval_500 +Gangliosidosis 2 5 2.798015789095532 0.0051417599115006 2.8567961165048543 4.902912621359223 0.2158556094961241 0.1574800557957235 1.2213224676890235 0.2960767122713962 1.9039254823866087 0.2239345049259472 0.0006444051117645 0.0242848323540905 0.0008973897437505 0.0001354907423541 0.0010694525645264 +Mucopolysaccharidosis 1 5 2.7411005074955126 0.0061233773355737 2.254854368932039 4.752427184466019 0.4843930061917075 0.2034155563537636 0.9831595235232706 0.7286567852681505 1.626107445717624 0.2463507210616131 0.0860283086388496 0.0526645480715484 0.1008375048293403 0.027832231049335 0.0974859568290139 +FDA approved drug targets 36 125 2.4721006262833627 0.0134321701892938 24.04854368932039 119.4247572815534 0.6623112070438231 0.5745671660823485 8.39802177443113 10.190737689187452 0.8635117376862006 0.3683507047501689 0.2313135395938717 0.7784325092296911 0.1650643812232873 0.0067112429149381 4.18301603632933e-06 +Primary mitochondrial disease 25 97 2.376528211927445 0.017476424909951 27.53640776699029 92.44660194174756 0.9978626953080288 0.3665723479658412 11.863754653333944 10.66022291187525 1.7959996823414457 0.3879563837717744 0.0470853039610131 0.5629626837931673 0.0011054509263847 1.2536729787029491e-05 3.2420995773990124e-08 +Dystroglycanopathy 3 5 2.251064019639001 0.0243814828832868 1.1407766990291262 3.662621359223301 0.5215502840164036 0.4426539556758241 0.960171596031666 1.086215896190079 1.0385204761089433 0.3023144828176274 1.0 1.0 1.0 0.3411306657380243 0.1998160014011807 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..bb223815fe879670f4aeec0046d304f3a864f27b --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 117, + "title": "Average number of proteins per term", + "value": 23.47008547008547 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f2ec1d43d221c1e42c9cfa755be3390ea2f73afa --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..83e21bce8569a8202d7af6b2928e2551931d9d66 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,48 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Gaucher disease 0.9778296382730456 3.816402675286792 0.0001354114515752 0.015719353367782 0.0030246307068672 2 P04062 1 +Neuronal ceroid lipofuscinosis 0.9667347534286552 3.538337555789043 0.0004026549508513 0.0460271971283034 0.0043913936959803 3 P50897,O14773 2 +Metachromatic leukodystrophy 0.8879813302216941 3.4086192501963284 0.0006529254072449 0.0735704015780691 0.0051794615793657 2 P07602 1 +Rhizomelic chondrodysplasia punctata 0.8683152788005524 3.097006813384476 0.0019548538071798 0.2046251310841098 0.012706549746669 3 O00116 1 +Hirschsprung disease 0.8170945157526108 3.0714357476046423 0.0021303200795179 0.2208200943165605 0.0131182868054527 2 P42892 1 +Gangliosidosis 0.881241191876907 2.798015789095532 0.0051417599115006 0.4529077462977967 0.0250660795685658 5 P07602,P16278 2 +Mucopolysaccharidosis 0.868404456470568 2.7411005074955126 0.0061233773355737 0.5125841629450563 0.027555198010082 5 P16278 1 +FDA approved drug targets 0.4297552537466921 2.4721006262833627 0.0134321701892938 0.79448045645314 0.0474061131574173 125 P54646,Q13423,P55011,Q14534,Q16850,P38435,O95864,P20020,Q8N0U8,Q99720,P31939,Q16134,P42574,Q9UGN5,Q9UBN7,P49354,P00374,P49721,P12235,P23786,P21964,P04818,P03886,P14735,P28074,P12236,P49356,P10253,P05067,P42345,P49327,Q16836,P05141,P39023,P16615,Q07864 36 +Hereditary nonpolyposis colorectal cancer 0.6954492415402589 2.457325150763576 0.0139975931327029 0.8078134090194754 0.0474061131574173 2 P52701 1 +Peroxisome biogenesis disorder 0.7320056458881175 2.4424859752456265 0.0145864963561284 0.8207886160616772 0.0474061131574173 3 O75381 1 +Zellweger syndrome 0.7320056458881175 2.4424859752456265 0.0145864963561284 0.8207886160616772 0.0474061131574173 3 O75381 1 +Primary mitochondrial disease 0.4571244476740473 2.376528211927445 0.017476424909951 0.8729049492439177 0.0552632895801154 97 Q9P032,Q96CU9,Q96IX5,P14854,Q9P0J0,Q6DKK2,O43676,Q9UBX3,P13073,P12235,Q86Y39,Q9Y584,P47985,Q9NWS8,P03886,Q9Y2R0,O14949,P00403,Q70HW3,Q5XKP0,P22695,Q9NPL8,Q99797,Q6P4A7,Q7KZN9 25 +Hermansky-Pudlak syndrome 0.7137599081853792 2.350761830486554 0.0187350214306669 0.8906051199654554 0.0562050642920008 3 O00203 1 +Albinism 0.7137599081853792 2.350761830486554 0.0187350214306669 0.8906051199654554 0.0562050642920008 3 O00203 1 +Dystroglycanopathy 0.7614699736518636 2.251064019639001 0.0243814828832868 0.9443116891182748 0.0680980324995365 5 Q8NAT1,Q9H9S5,O43505 3 +Ehlers-Danlos syndrome 0.695213849652237 2.068418981485577 0.0386006418345112 0.9900058040731397 0.0969332028796709 4 Q9NWM8,Q96L58 2 +Schizophrenia 0.6283376354587991 1.908110962934753 0.0563768760736251 0.9988742725213102 0.1346141734819213 3 P21964 1 +Amyloidosis 0.6811508666273676 1.8640466826945237 0.0623151489273698 0.999462154833204 0.1458174484900455 5 P03886,Q9Y287 2 +Ichthyosis 0.6651879192323118 1.7484605511525928 0.0803843108025892 0.9999447991808664 0.1774521578094894 9 P04062,P51648 2 +Leber congenital amaurosis 0.5469661610268467 1.642700162072974 0.1004449852484596 0.999995819345396 0.2098582727512461 2 O15078 1 +Alzheimer disease 0.5843247418684883 1.3782575149284158 0.1681237953064165 0.999999999556526 0.3333980347601819 5 P03886 1 +Primary microcephaly 0.56770112072999 1.366996903886609 0.1716262759690834 0.999999999729306 0.3346712381397127 12 Q86XL3,P42695 2 +Congenital muscular dystrophy 0.5903677179026072 1.290413285122869 0.1969072018959652 0.9999999999927958 0.3656848035210783 6 Q8NAT1,Q9H9S5,O43505 3 +Alport syndrome 0.4568261376896369 1.1203814944710786 0.2625512274123767 0.9999999999999996 0.464366284361259 2 P35579 1 +Dwarfism 0.3775351064164536 1.1125094849598525 0.2659191542923449 0.9999999999999998 0.464366284361259 50 Q13535,O95613,Q96L58,O15228,O00116,Q13426,P48651,Q14739,Q96HY6 9 +Lissencephaly 0.5100616362845677 1.0474068080577836 0.2949119930862385 1.0 0.5000681621897087 12 Q8NAT1,Q9H9S5,O43505,Q6ZXV5,P43034 5 +Systemic lupus erythematosus 0.4560840385176627 0.9646426746382116 0.3347238170596016 1.0 0.5399969868824377 3 P12956,P13010 2 +Congenital disorder of glycosylation 0.4292230628809104 0.8812335868751255 0.3781914038320288 1.0 0.5898866210662453 19 Q8N511,Q9BT22,Q2TAA5,P51571 4 +Diabetes mellitus 0.4786201033878694 0.8039628454861362 0.4214184330808666 1.0 0.6228965645816675 10 O76024,P03886 2 +Neurodegeneration 0.3056851431697597 0.7962062233676229 0.4259121809105419 1.0 0.6228965645816675 139 Q13510,P05067,P42858,P04062,Q96RL7,Q9Y287,P49902,P03886,Q13315,O14773,Q8IV08,P27544,O75503,P50897,Q14108,Q99720,Q9NSD9,P54802 18 +Cataract 0.3753879498596444 0.7738780333364897 0.4390029209364192 1.0 0.6312913040282676 28 Q9BYI3,Q53H12,P18074,Q15800,P11166,Q01968,O15228,O00116,O76024,Q8WVX9,P48449,Q9BQS8,O00443 13 +Holoprosencephaly 0.3941073512252054 0.7590224451973007 0.4478391302080873 1.0 0.6312913040282676 2 A5YKK6 1 +Epilepsy 0.3223156452215817 0.6895395155200313 0.4904838151444326 1.0 0.6604843221216987 70 Q13510,P42345,Q96RL7,P03886,O14773,P27544,O75503,Q14108,P16615,P31939 10 +Parkinsonism 0.456243293990126 0.6885136654637645 0.4911293677315196 1.0 0.6604843221216987 10 Q15043,P04062,O75165 3 +Kartagener syndrome 0.3895535453749701 0.6072267535010328 0.5437004398653116 1.0 0.699043422683972 3 Q9NVR5,Q86Y56 2 +Autism 0.438029249943113 0.5699459202903769 0.5687143781467352 1.0 0.7129314352944012 8 P27635,Q9NVH6,O14874,Q14156 4 +Diamond-Blackfan anemia 0.3908698341295282 0.5312038901039804 0.5952774975514563 1.0 0.7254944501408374 15 P42766 1 +Glycogen storage disease 0.4097479671957784 0.4589120442007354 0.6462973293339116 1.0 0.7559572307213186 10 P13473,P46976,P35573,Q04446,P10253 5 +Spinocerebellar ataxia 0.3996141818393433 0.4550180876043628 0.6490962262257995 1.0 0.7559572307213186 12 O14773 1 +Premature ovarian failure 0.3580391012547479 0.4501830402421575 0.6525784641269503 1.0 0.7559572307213186 3 O60879,Q06787 2 +Primary ciliary dyskinesia 0.3753648569760716 0.4289640853460629 0.6679493614104004 1.0 0.7633984329360181 4 Q9NVR5,Q86Y56,P57076 3 +Limb-girdle muscular dystrophy 0.3702635026079574 0.2822548240026952 0.777748122984502 1.0 0.8425604665665438 10 Q8NAT1,Q9H9S5,Q9Y5P6 3 +Maple syrup urine disease 0.2940490081680211 0.2545432483737671 0.7990758966842204 1.0 0.8577236689179246 2 P11182 1 +Microphthalmia 0.3366612837484379 0.1517521660418157 0.8793824110379831 1.0 0.9353431099222184 6 P53701 1 +Leukodystrophy 0.3032582929898923 0.1312261355804064 0.8955964215250953 1.0 0.9440070389048304 19 P15289,P07602 2 +Hypotrichosis 0.3253578244844098 0.1158224719044161 0.9077932403688916 1.0 0.9483197243139312 7 Q8IWS0,P46778,P48449 3 +Emery-Dreifuss muscular dystrophy 0.2781374453395442 0.0397442238682305 0.9682970439632465 1.0 1.0 5 Q9BTV4 1 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..28f4512186b9b24932e99c5fb7951a789830d045 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hemolytic uremic syndrome", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Peters anomaly", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Senior-Loken syndrome", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AAGAB", "AARS", "AARS2", "ABAT", "ABCB1", "ABCB7", "ABCD4", "ABHD12", "ABI1", "ACAA1", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACY1", "ADAR", "ADD3", "ADK", "ADNP", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AGTPBP1", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKAP9", "AKR1B1", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "AMPD2", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APEX1", "APOL2", "APP", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ARMC9", "ARPC1B", "ARSA", "ASAH1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATL3", "ATM", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATR", "ATXN10", "AURKA", "AURKB", "B3GALT6", "B4GAT1", "BAG3", "BANF1", "BARD1", "BAX", "BAZ1B", "BCAP31", "BCAS3", "BCAT2", "BCKDHB", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BICD2", "BIRC6", "BLM", "BLMH", "BMS1", "BPTF", "BRAT1", "BRCA1", "BRD4", "BRI3BP", "BUB1B", "BUD23", "C19orf70", "C1QBP", "C21orf59", "C3orf58", "CAD", "CALM3", "CALR", "CAMK2G", "CANX", "CAPN1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC22", "CCDC47", "CCDC6", "CCNB1", "CCNB2", "CCT5", "CDC16", "CDC25C", "CDC27", "CDC37", "CDC42", "CDC6", "CDC73", "CDH2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDKAL1", "CENPF", "CEP250", "CEP290", "CEP55", "CERS1", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHM", "CISD2", "CIT", "CIZ1", "CKB", "CKMT1A*", "CLCC1", "CLCN7", "CLIC1", "CLIP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "COA3", "COA7", "COASY", "COG5", "COG7", "COG8", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COX15", "COX2", "COX4I1", "COX5A", "COX6B1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CREBBP", "CRK", "CRTAP", "CSDE1", "CSE1L", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTDP1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DAD1", "DARS", "DARS2", "DAXX", "DBN1", "DBT", "DCPS", "DCTN1", "DCUN1D1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIS3", "DKC1", "DLD", "DLST", "DNAAF2", "DNAAF5", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPH1", "DPM1", "DSC2", "DSE", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "ECT2", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFR3A", "EFTUD2", "EHHADH", "EHMT1", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "ENO2", "EPB41", "EPB41L3", "EPHX1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERC1", "ERCC2", "ERCC3", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXOC6B", "EXOC8", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAH", "FAM120A", "FAM126A", "FAM50A", "FAM83D", "FANCA", "FANCD2", "FANCI", "FAR1", "FARSB", "FASN", "FASTKD2", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLCN", "FLNA", "FLNB", "FLNC", "FMR1", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FUBP1", "FUCA1", "FUS", "FYCO1", "G6PD", "GAA", "GALE", "GALK1", "GALNT2", "GAMT", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GCDH", "GCLC", "GCLM", "GDAP1", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GINS1", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI3", "GNB1", "GNE", "GNPAT", "GNS", "GOLGA5", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPHN", "GPI", "GPT2", "GRB2", "GSK3A", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2E2", "GTF2H1", "GTF2I", "GTPBP3", "GUF1", "GUSB", "GYG1", "GYS1", "H3-3A*", "H4C1*", "HADH", "HADHA", "HADHB", "HARS2", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HELLS", "HERC2", "HEXA", "HEXB", "HIBCH", "HIP1", "HIP1R", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMMR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS5", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IFT52", "IGBP1", "IGF2R", "IKBKB", "ILF3", "ILK", "IMPDH2", "INF2", "INPPL1", "INTS1", "INTS12", "INTS8", "IPO7", "IRF2BPL", "IRS4", "ISCA2", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KATNB1", "KDM1A", "KDM3B", "KDM5A", "KDSR", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KLC2", "KMT2A", "KNSTRN", "KTN1", "L2HGDH", "LAMB1", "LAMC1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LGALS3", "LGALS3BP", "LIN9", "LIPA", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRP1", "LRPPRC", "LSS", "LTA4H", "LZTFL1", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAN2B1", "MAP1A", "MAP1B", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAPK1", "MAPK3", "MAPKAPK3", "MARS", "MARS2", "MASTL", "MATR3", "MBD1", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM3AP", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MECR", "MED1", "MED17", "MED23", "MESD", "MFGE8", "MGME1", "MID1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMACHC", "MOCS1", "MOGS", "MORC2", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTHFR", "MTMR2", "MTO1", "MTOR", "MTPAP", "MTR", "MUT", "MVD", "MYH10", "MYH14", "MYH9", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCKIPSD", "NCOR1", "NCSTN", "ND1", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NET1", "NEU1", "NF1", "NHLRC2", "NHP2", "NIPBL", "NISCH", "NME1", "NNT", "NONO", "NOP56", "NOTCH2", "NPC1", "NPC2", "NPM1", "NRP1", "NSD2", "NSDHL", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NUBPL", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OSBPL2", "OTULIN", "OXCT1", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAFAH1B2", "PARD3", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PCNT", "PDAP1", "PDCD4", "PDHA1", "PDHB", "PDK1", "PDK3", "PDSS1", "PDSS2", "PEPD", "PEX14", "PEX19", "PEX5", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIK3C2A", "PIK3R2", "PISD", "PKM", "PKP2", "PLAA", "PLCG1", "PLCG2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNP", "PNPLA4", "PNPLA6", "PNPO", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POLR3B", "POMGNT2", "POMP", "POP1", "POR", "PPA2", "PPFIBP1", "PPIB", "PPIF", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R5D", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRC1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PTDSS1", "PTPN11", "PTPN23", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "RAB10", "RAB11B", "RAB18", "RAB23", "RAB3GAP2", "RAB7A", "RAB8A", "RABEP1", "RABL3", "RAC1", "RAD21", "RAD23A", "RAD23B", "RAF1", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RB1", "RBBP4", "RBM10", "RBM12", "RBM15", "RBM28", "RBM6", "RBM7", "RBMX", "RDH11", "RDX", "REL", "RELA", "REPS1", "RFC1", "RFC2", "RHEB", "RHOA", "RINT1", "RIPK1", "RMC1", "RMND1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF213", "ROCK1", "ROCK2", "RP2", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL26", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS28", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RRM1", "RRM2", "SACS", "SAMHD1", "SAR1B", "SARS", "SART1", "SATB2", "SBDS", "SC5D", "SCARB2", "SCO1", "SCO2", "SCRIB", "SCYL1", "SCYL2", "SDHA", "SDHB", "SEC23A", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SELENBP1", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETDB1", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC39A14", "SLC3A2", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SMYD3", "SND1", "SNRNP200", "SNRPE", "SNX14", "SNX3", "SOAT1", "SOD2", "SON", "SORD", "SPART", "SPATA5", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN2", 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a/protein_atlas_molecular_function/consensus.joblib b/protein_atlas_molecular_function/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..b30da9ebe86b85ab25d30cacfc1a4fb518b23a09 --- /dev/null +++ b/protein_atlas_molecular_function/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:79158be299614e5c0024bd3980791c696c066ddfda2354f01f532b240e473d17 +size 95210 diff --git a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d755cdcab3690d01e3a15e6f7e4f900e125738e8 --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 16 42 3.1620358920273945 0.0015667025256198 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0160511047553097 0.0337004996412966 0.0331776056462107 0.018618787305556 0.1034824108943545 +Protease 19 84 2.790488565978257 0.0052628559067466 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 0.0109987015762092 0.0258595758887776 0.0232762416433923 0.0101823438138163 0.0086568543214958 +Carboxypeptidase 3 7 2.762107546306645 0.0057429557961286 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 0.0002205530010257 0.0023758658868836 0.0003602808960722 0.000371706641515 0.0049531384619904 +Translocase 8 23 2.3733847178585963 0.0176258943076055 8.031553398058252 23.23543689320388 0.8266305625937611 0.3429767730570308 3.903132239147793 3.2553774114037415 1.2917497354360188 0.3272657999875639 0.3885096135437567 1.0 0.1132051672598368 0.0005812813538685 0.0005781925850387 +Glycosidase 6 19 2.3307638261919954 0.0197658165413545 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 0.0476798475193373 0.1908924307699622 0.0640285846884502 0.0198035379531722 0.0043866153154496 +Serine protease 1 9 2.3003520263242723 0.0214282843894613 2.325242718446602 9.143203883495143 0.6368444182316527 0.3935197397745671 1.3833418412762697 1.1580773433535438 0.9813004733593778 0.2874962562446074 0.1783105780413945 0.1114073342812727 0.2070995190727305 0.1139407547181512 0.3280048671308403 +Glycosyltransferase 13 37 2.2806866531732126 0.0225669955128711 8.383495145631068 33.63106796116505 0.9005425082235603 0.4380439374186179 3.633517034002208 4.6602851932859135 0.9766631781348049 0.3531801259598526 0.2525940451168345 1.0 0.317502679856318 0.008252274850028 0.0303953469358753 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e8ebfbbf66be98ef93dd6b9a3fa035a79230c9e4 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 94, + "title": "Average number of proteins per term", + "value": 43.57446808510638 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d7a1357cb24662f72267448bfb28fb75912c0364 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5b0512dab9c97dcb076398c13b135f734f1efbfc --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,36 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cyclin 0.8681446907817975 3.31570080075461 0.0009141364172948 0.0823765177134168 0.0122755461751026 2 P14635 1 +Calcium channel 0.8401400233372249 3.1826379165323377 0.0014593999297918 0.1282771984698937 0.0147270037408266 2 Q8NE86 1 +Receptor 0.6320224757765994 3.1620358920273945 0.0015667025256198 0.1370387774428966 0.0147270037408266 42 P35613,Q14739,Q9NS69,P24390,O15118,Q8WTV0,P14735,O15031,Q9Y5M8,O15173,Q14108,Q99623,Q99720,O43731,P30825,O00264 16 +Monooxygenase 0.8847306354904094 2.9632017292078148 0.0030445696781362 0.2492076008960736 0.0238491291454007 4 Q6UW02 1 +Porin 0.8751075879328145 2.920043308496958 0.0034998274484918 0.2807604604034626 0.0253064446275565 4 P21796,P45880 2 +Prenyltransferase 0.8071496030017553 2.8098598468633496 0.0049563078019727 0.3731520783036487 0.0291004973667169 3 P49356 1 +Threonine protease 0.8059527283338072 2.804136871816832 0.0050451482642805 0.3783911803123817 0.0291004973667169 3 P28072,P28074 2 +Protease 0.5068166731039164 2.790488565978257 0.0052628559067466 0.3910473900155057 0.0291004973667169 84 P55786,Q16740,Q9UIQ6,Q8TCT9,P42892,P67812,P42785,Q9H3G5,Q9HB40,Q9UPU5,P28072,P14735,O75844,P28074,Q70CQ2,O14773,P10619,Q99797,Q9NZ08 19 +Carboxypeptidase 0.896911216178762 2.762107546306645 0.0057429557961286 0.4180634965777619 0.0299909913797827 7 Q9H3G5,Q9HB40,P42785 3 +DNA-directed DNA polymerase 0.778310005205564 2.4725933306136287 0.0134136683866692 0.7190048206292743 0.0548210794933438 4 P28340 1 +Translocase 0.6296395712466646 2.3733847178585963 0.0176258943076055 0.8120556807054479 0.0637243871121122 23 Q03519,Q13423,Q9HD20,P03886,P00403,Q03518,P16615,P47985 8 +Glycosidase 0.6562863354520222 2.3307638261919954 0.0197658165413545 0.8468893897927593 0.0688143242550862 19 O60502,P04062,P16278,Q9BTY2,P54802,P10253 6 +Serine protease 0.7775707985212685 2.3003520263242723 0.0214282843894613 0.8694701215674258 0.0719378118789058 9 Q16740 1 +Glycosyltransferase 0.538828862449443 2.2806866531732126 0.0225669955128711 0.8830021295423945 0.0727588848497657 37 Q10472,P04062,P43490,O60512,P09874,Q96L58,Q9UGN5,Q13126,Q9BT22,O43505,Q8NAT1,Q8N4A0,Q2TAA5 13 +Tumor antigen 0.7282333429878912 2.2312702235166437 0.0256632348227683 0.913173060964222 0.0753857522918819 4 Q9Y5V3 1 +Metalloprotease 0.5080065362930604 1.7438972520172218 0.0811770079035287 0.999650220547046 0.19127274222343 27 P55786,P42892,P14735,Q9UIQ6,O75844,Q99797 6 +Hydrolase 0.3067936907495405 1.7426620962598045 0.0813926562652893 0.999657853718216 0.19127274222343 411 P55786,P15289,Q8N2A8,Q969T7,Q16740,Q15165,P06280,Q9UIQ6,Q8IV08,Q8TCT9,P07099,Q9H2U1,Q13867,P31939,Q13510,Q8NHH9,P42892,P67812,Q9H8H2,P16278,Q9NPH0,P49902,A8MXV4,P42785,Q8NCG7,Q9H3G5,Q9UBN7,Q9HCE1,P50897,Q86YN1,Q9HB40,O43681,P11117,Q9H773,Q9UPU5,Q14566,P61020,P04062,Q7Z478,Q9UQ84,P28072,P14735,Q9H857,Q9NUJ1,O94919,Q9P2D1,O75844,Q8NCC3,P28074,Q14197,P10253,P49327,O60502,Q70CQ2,P17900,Q9BRF8,Q9BTY2,Q9H6S0,O14773,Q15907,P10619,P28340,P50570,O60841,Q99797,Q8NHP8,Q14674,Q9ULX3,Q9NZ08,P54802,Q07864 71 +Host cell receptor for virus entry 0.5655805776885805 1.6215048588458407 0.104909408781358 0.9999701119726114 0.2347972482249441 16 P35613,O15118,Q8WTV0,P14735,Q14108 5 +Oxidoreductase 0.330909834029921 1.5788748696945982 0.1143647612254814 0.999988985633678 0.2500066873301222 179 P30519,Q15392,Q8NBX0,Q96CU9,Q14534,Q8N4Q0,P09601,Q16850,Q8N0U8,P21912,O76062,P32119,P13073,P00374,P16435,Q14739,Q99536,Q53GQ0,P51648,Q06136,O95881,Q15067,Q9UHG3,Q15800,Q16836,P78417,P49748,Q6UW02,Q96LJ7 29 +Growth factor 0.4822053675612672 1.2683906941470964 0.2046584632089028 0.9999999995512088 0.3926101130946298 2 P06744 1 +Guanine-nucleotide releasing factor 0.4614619017082508 1.1673854567546778 0.243054741592346 0.999999999995714 0.4310782209373685 21 P80303 1 +Peroxidase 0.5155560630669561 0.9197936921211568 0.3576805803052134 1.0 0.5898592026085976 6 P32119 1 +Ion channel 0.4916912531108983 0.8722906607439467 0.3830498312505754 1.0 0.6102827819924422 10 Q9C0H2,Q9UM00,Q8NE86 3 +Transferase 0.2651551513723746 0.7012101346833883 0.4831718860014709 1.0 0.7209231314942581 422 Q13546,P46934,P51812,Q8NAT1,Q7L592,P09874,P52429,Q9H9T3,Q8NF37,Q96G23,O94822,P23786,Q8IXJ6,P04062,Q9Y5P6,P06493,O95071,Q00535,Q13126,Q8NCC3,Q5T2R2,Q9H7B4,P78417,Q86UY6,Q8TBX8,O15217,P37268,P43490,Q9BRR6,O60725,Q8N4A0,P31939,Q6P2P2,Q9UGN5,Q06520,Q7LGA3,O95628,O00116,P49356,Q15418,Q13535,O60512,Q96L58,Q9NUQ2,P52789,Q7Z2T5,P27544,P28340,Q03164,O43505,P54646,P49354,Q10472,Q13395,Q9NRN7,Q13315,P48729,P42345,Q16836,Q9BT22,Q07864,P50750,Q9H9S5,Q9BWH6,Q2TAA5,O43708,O15228,P48651,Q96N66,Q6UX53,P21964,P04818,O15269,Q9BTU6,Q6ZXV5,Q16763,O14965,P49327,P78527,O14929,Q96GX5 81 +Endonuclease 0.3757456815087195 0.5854409453682184 0.5582512639307109 1.0 0.7832181911863705 21 Q9UQ84,Q8N2A8 2 +Exonuclease 0.3652872149010109 0.5172987825848876 0.6049476037672905 1.0 0.8117173280419641 21 Q9UQ84,P28340 2 +Aminopeptidase 0.4115174061218551 0.5150415147361584 0.6065240101983185 1.0 0.8117173280419641 12 P55786,Q9UIQ6 2 +Methyltransferase 0.2942150983891429 0.3261475073029819 0.7443127547676043 1.0 0.9367287428070624 53 Q9H7B4,P21964,Q13395,Q6P2P2,O60725,Q7Z2T5,Q03164,Q6UX53 8 +Nuclease 0.2993241702552124 0.2950287896063848 0.7679718871004668 1.0 0.9367287428070624 39 Q9UQ84,Q8N2A8,P28340,O94919 4 +Serine/threonine-protein kinase 0.287693699057549 0.2886882824521531 0.772819930353037 1.0 0.9367287428070624 81 P54646,Q13546,P42345,Q13535,P11802,P50750,P06493,Q13315,P78527,Q00535,P51812,P48729,Q15418,O14965,Q96GX5 15 +Heparin-binding 0.3585872934150367 0.2272743605229907 0.8202104088082431 1.0 0.9547900051489429 8 P05067 1 +Acyltransferase 0.2859217311185698 0.1889775920800999 0.8501103792685947 1.0 0.9547900051489429 39 O15269,O15228,Q9NUQ2,Q86UY6,O14929,Q9H9T3,Q8NCC3,Q96N66,P23786 9 +Nucleotidyltransferase 0.3017535908695559 0.159915209570455 0.8729478672052489 1.0 0.9547900051489429 23 Q9Y5P6,P28340,Q9BWH6,P30876,Q13057,Q07864 6 +Rotamase 0.3004307147262943 0.130372154185386 0.8962719962799248 1.0 0.9683858350610682 20 Q9NWM8,O95302,Q9Y680 3 +Initiation factor 0.26336392570275 0.0146797816460717 0.9882876495309112 1.0 1.0 37 P55010,O60841,P49770,Q7Z478 4 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..c3a703da7cc7ec47fc0f5048ef63a6e1c81e2e10 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "IgG-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABAT", "ABCB1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADO", "ADPGK", "ADSL", "ADSS", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMPD2", "ANKHD1", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "ANXA3", "APBB1", "APEH", "APEX1", "APIP", "APP", "APRT", "AQR", "ARAP1", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "AS3MT", "ASAH1", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATE1", "ATG3", "ATG4B", "ATIC", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATR", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BANF1", "BAP18", "BARD1", "BAZ1B", "BAZ2A", "BCAT1", "BCAT2", "BCKDHB", "BCKDK", "BCLAF1", "BCR", "BCS1L", "BDH2", "BEND3", "BIRC6", "BLM", "BLMH", "BLVRA", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BRD8", "BRMS1L", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUD23", "BZW1", "BZW2", "CAD", "CALCOCO1", "CALD1", "CALR", "CAMK1", "CAMK2D", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBL", "CBR1", "CBX3", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CDC25C", "CDC37", "CDC42", "CDC42BPB", "CDC5L", "CDCA7L", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CEP290", "CEP55", "CEP97", "CERS1", "CERS2", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHM", "CHORDC1", "CHRAC1", "CHTF18", "CHTF8", "CHUK", "CIRBP", "CIT", "CKB", "CKMT1A*", "CLCC1", "CLGN", "CLIC1", "CLIC4", "CLK3", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMBL", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT4", "CNOT7", "CNP", "COASY", "COLGALT1", "COMT", "COPA", "COPS5", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CROT", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CUL5", "CXADR", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENND5B", "DENR", "DERA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DICER1", "DIEXF", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DR1", "DRG1", "DRG2", "DSE", "DST", "DSTN", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EDC3", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "ENSA", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERO1A", "ERP44", "ESD", "ESPL1", "ETFDH", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "FADS2", "FAH", "FAHD1", "FAM120A", "FAM120B", "FAM208A", "FAM20B", "FAM213A", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLYWCH1", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXC1", "FOXRED1", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNE", "GNG5", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSR", "GSS", "GSTA4", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOOK1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INA", "INF2", "INPP4A", "INPPL1", "INTS11", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRS4", "ISG20L2", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITPA", "ITPK1", "IVD", "JMJD6", "KARS", "KAT7", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LEMD3", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIPA", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT4", "LRP1", "LRPAP1", "LRPPRC", "LRRC8A", "LRRFIP1", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MATR3", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCRS1", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL13", "METTL25", "METTL7B", "MFN1", "MGEA5", "MGME1", "MGST2", "MGST3", "MICAL3", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOCS3", "MOGS", "MORC2", "MORC3", "MORF4L1", "MOV10", "MPHOSPH10", "MPHOSPH6", "MPI", "MPRIP", "MPST", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL50", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MTA1", "MTA2", "MTAP", "MTERF3", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA40", "NAA50", "NADK2", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCAM1", "NCBP2", "NCBP3", "NCL", "NCOA5", "NCOR1", "ND1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NES", "NET1", "NEU1", "NF1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT16", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OTUB1", "OTUD7B", "OTULIN", "OXCT1", "OXSM", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAXBP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCNT", "PCYOX1", "PDCD4", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEBP1", "PELO", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF2", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PIGK", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PMF1", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POMGNT2", "POMP", "PON2", "POP1", "POR", "POU2F1", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R8", "PPP5C", "PPP6C", "PPT1", "PPWD1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKCA", "PRKCB", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS2", "PRUNE1", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT1", "RAB10", "RAB11B", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RAF1", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REL", "RELA", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RGS10", "RHOA", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP14", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRM1", "RRM2", "RRP1B", "RRP7A", "RRP8", "RRP9", "RSF1", "RTCB", "RTF1", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SACS", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAP30BP", "SARM1", "SARNP", "SARS", "SARS2", "SART3", "SATB2", "SC5D", "SCAF1", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL1", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC61A1", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SGK3", "SGPL1", "SGTA", "SH3RF1", "SHMT1", "SHMT2", "SHPRH", "SHTN1", "SIGMAR1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A2", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SMYD3", "SMYD4", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRA1", "SRBD1", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "SSU72", "STAMBP", "STAT1", "STAT3", "STAU1", "STAU2", "STK4", "STMN1", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SULT2A1", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TAF15", "TALDO1", "TAMM41", "TAOK1", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCF20", "TCP1", "TDP2", "TDRKH", "TECR", "TERF2", "TERF2IP", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM50", "TIMM8B", "TIMM9", "TIMMDC1", "TJP1", "TK1", "TKFC", "TKT", "TM7SF2", "TMCO1", "TMEM109", "TMLHE", "TMOD1", "TMOD3", "TMTC3", "TNRC6A", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAF2", "TRAP1", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSN", "TSNAX", "TST", "TSTA3", "TTK", "TTYH3", "TUFM", "TWF2", "TWNK", "TXNDC12", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBE4B", "UBP1", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UCK2", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "ULK3", "UMPS", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCRFS1", "UROD", "USP10", "USP11", "USP14", "USP15", "USP19", 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sha256:6e37b24e9112ea59acc388366bc02d16159192625f69f811bcd22b5535229aa9 +size 142306 diff --git a/protein_atlas_protein_class/consensus.joblib b/protein_atlas_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..86db8a9dc8cd032478052c48dd45f7ce55a3b465 --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d9ab78bee418222f77b72e213c5c31537575566482c2d9af02f911a6230426d4 +size 106743 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4172b790a6ff65eaf6ab76f62a69f6541b99aca6 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted membrane proteins 236 571 8.65787904010562 4.806231482188449e-18 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 2.613394216447501e-09 2.5176771208612805e-06 1.1304892940470225e-13 6.397240040689021e-33 5.8691610812655514e-31 +Transporters 116 369 4.972938604134393 6.594555095094276e-07 108.9004854368932 367.3009708737864 1.469396346451591 0.4764419032567517 40.40141182476491 35.10022679965902 2.352674986871393 0.4490473364946538 0.0004227150055441 0.001492640194769 0.0004827346345 2.942948850150603e-10 6.581220167366133e-17 +Predicted secreted proteins 20 53 3.3648165879174763 0.0007659455637061 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 0.0221678285357259 0.0423139640945197 0.0448159981929523 0.1185127466126223 0.022350131379284 +Metabolic proteins 174 962 2.5967834177966784 0.009410123781357 167.96116504854368 885.0898058252427 0.3517504365488901 0.4992811695371688 49.08590099318301 81.73901275864796 1.4937513760737942 0.4046478208580187 0.0181705483015784 0.1629113636067423 0.0016341052907355 4.506432022081773e-11 3.055063853427215e-10 +FDA approved drug targets 36 125 2.4721006262833627 0.0134321701892938 24.04854368932039 119.4247572815534 0.6623112070438231 0.5745671660823485 8.39802177443113 10.190737689187452 0.8635117376862006 0.3683507047501689 0.2313135395938717 0.7784325092296911 0.1650643812232873 0.0067112429149381 4.18301603632933e-06 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ec3543bc0ac32a63dfd532f7791406b9e49b0ef0 --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 548.85 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a3dec34338c12b997c0e9edafb394cefcc7d8c3b --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..60d62f3cc1cf13f0639cfc8b4f044fc82c149a99 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,10 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.641107669794949 8.65787904010562 4.806231482188449e-18 1.1612462964376898e-16 1.1612462964376898e-16 571 Q6IAN0,P30519,Q15392,Q9NS69,P24390,P55899,P53985,P01889,O75165,O60831,O43169,Q3B7T1,Q9P035,Q9H9B4,Q9BQE5,Q13641,Q07820,P09601,P51812,Q6NTF9,Q14108,O00461,Q99720,O43676,Q9H061,O60637,P43307,Q16134,O60830,Q5BJF2,Q8N511,O75964,O43819,P67812,O15400,Q16706,Q9UM00,Q9UL01,Q8TB61,O95197,Q14849,P52429,Q9C0H2,O75381,Q5VW38,Q9UBX3,O43657,Q96GC9,Q8NF37,Q99595,Q96ES6,Q9NPR9,O43731,Q96G23,Q9Y584,O95470,Q86UE4,Q8WTV0,Q9BXK5,P03886,Q13505,Q9Y2R0,P51648,Q8WY22,O75844,Q8NCC3,Q9Y282,Q03518,Q06136,Q96A26,Q15629,O75071,Q9UDW1,Q9Y487,Q70HW3,O15118,Q9H1E5,Q15800,Q9UDX5,Q9BTX1,Q9P2W9,Q3SXM5,Q6UW02,O15173,O14925,P37268,Q15070,Q9NQC3,Q9HD45,Q8N2A8,Q9Y3B3,Q13423,Q8NBX0,Q93050,Q9HD20,Q86XL3,O60725,Q8NAN2,Q9UIQ6,Q16850,P38435,Q9H2V7,Q9P0J0,Q567V2,Q8N0U8,O43772,O95202,Q8IXM6,P57105,P42892,O15127,O76062,Q9BSK2,Q9Y287,Q9Y6C9,Q9H4I3,O15031,O43292,P13073,Q8IXU6,Q9Y5M8,Q86YN1,Q96EX1,P24539,O96005,P12235,P11117,Q86Y39,Q5T9L3,Q9NWS8,Q03519,P13473,A1L0T0,Q53GQ0,Q9NQX7,O94919,Q96KC8,Q8N5M9,Q8NBN3,P00403,Q9UBU6,Q9BUN8,O00264,P12236,Q96PC5,P30825,Q9NZ45,Q9NX40,P05067,O14678,Q13535,Q9NUQ2,Q8IZA0,Q15363,P27544,Q9NZJ7,Q6P4A7,P16615,Q9NX00,Q7KZN9,P54646,Q07065,O95249,P42858,Q13277,Q8WVC6,Q9Y619,Q14534,Q8IV08,Q8TCT9,Q9BUR5,Q9H2U1,P20020,Q96SK2,Q8TBA6,Q86V85,Q9NR77,Q13190,Q8NCG7,Q96KA5,P16435,Q14739,O15360,P49755,Q96A33,Q16625,Q10472,O15260,P51798,Q96NB2,Q8TB36,Q15388,Q92896,Q8TAA9,Q9BT22,Q9NPL8,Q6NUM9,Q8NE01,P51571,P35613,Q9NUT2,Q96IX5,P55011,O95864,Q9Y2G8,Q9H9S5,Q9BWH6,Q2TAA5,O75448,P11279,Q15043,Q8NHH9,Q9H3N1,Q15041,Q9BVK6,Q8NE86,Q15904,Q9UBM7,P48651,P08183,Q96SY0,Q96N66,O15269,Q969V3,Q7Z3C6,O76024,Q6ZXV5,O75845,P57088,Q12907,O43808,O00767,P05141,Q14674,Q9NPA0,Q9BTV4 236 +Transporters 0.471669578288431 4.972938604134393 6.594555095094276e-07 1.3189027563037372e-05 6.594555095104276e-06 369 P55060,P24390,P53985,O60831,Q9H9B4,P45880,Q2M389,P46934,Q6NTF9,Q14108,Q99720,Q9H061,O60637,Q5BJF2,Q8N511,O75955,Q9UM00,Q8TB61,Q14849,O76094,Q9C0H2,Q5VW38,Q9UBX3,Q8WTV0,P07602,Q8WY22,O75844,Q03518,Q15629,Q70HW3,O15118,Q9BTX1,Q9H2D1,Q15070,Q9Y3B3,Q93050,Q9HD20,Q9H2V7,O43772,O95202,P52292,Q9BRK5,P57105,O15127,Q9BSK2,Q9Y287,Q9Y6C9,Q96P70,P13073,Q8IXU6,O96005,P12235,Q5T9L3,Q03519,P13473,P00403,Q9UBU6,Q9BUN8,P12236,Q96PC5,P30825,P05067,O14678,Q15363,Q9NZJ7,Q6P4A7,P16615,Q8IYU8,P54646,Q07065,Q13277,Q9Y619,Q9BUR5,P20020,Q8TBA6,P21912,Q96RL7,Q9NR77,Q13190,P49755,Q96A33,Q16625,O15260,P51798,O15397,Q96NB2,Q8TAA9,Q07812,Q96KP1,Q8NE01,P35613,Q9NUT2,P55011,P14635,Q9BQT8,P11279,Q15043,Q8NHH9,Q9C0E2,Q9H3N1,Q9Y512,Q15904,P08183,O43681,Q96N66,O95067,Q969V3,Q92973,Q7Z3C6,O76024,Q6ZXV5,P57088,P50570,O43808,P05141,Q9NPA0 116 +Predicted secreted proteins 0.6181821071401236 3.3648165879174763 0.0007659455637061 0.0152079540849599 0.0030637822548245 53 P80303,P43490,Q15165,Q9Y4P3,Q9BUR5,Q9H9S5,Q14667,Q9UM22,Q02818,Q9Y287,Q9HB40,Q99584,Q8WUJ1,P09429,Q9UMX5,P14735,O94919,P05067,Q9BTY2,Q9NZ08 20 +Metabolic proteins 0.3197298758759375 2.5967834177966784 0.009410123781357 0.1722909494418745 0.0235253094533927 962 P30519,Q15392,Q969T7,Q15165,Q8N4Q0,P09601,P07099,P51812,O43676,O75964,P67812,P16278,Q9NPH0,Q8TB61,Q14849,Q9UBX3,P00374,P50897,Q96G23,P23786,O95470,P04062,Q8WTV0,P03886,P07602,P51648,O75844,O14949,Q13126,Q8NCC3,Q06136,Q9UDW1,Q9Y487,Q9Y680,Q9H7B4,Q70HW3,O15118,Q9UHG3,Q15800,P78417,P17900,Q9BTX1,P22695,Q86UY6,O14773,Q8TBX8,P10619,P35269,O15217,Q9H2D1,P37268,P54802,P55786,Q8N2A8,Q13423,P43490,Q8NBX0,Q93050,Q9BRR6,O60725,Q16850,O95302,Q9P0J0,O43772,Q8N4A0,P31939,Q13510,O76062,Q6P2P2,Q9H7Z7,Q9UGN5,Q06520,Q7LGA3,O43292,P13073,P48449,Q86YN1,P24539,P12235,P11117,Q86Y39,Q9H773,P47985,O95628,Q53GQ0,O00116,P00403,P12236,P49356,Q15418,P30825,O60502,Q13535,O60512,P49748,Q96L58,Q9NUQ2,P52789,Q7Z2T5,P27544,P28340,Q03164,O43505,P16615,P54646,Q9Y619,Q14534,Q8IV08,P20020,P49915,P21912,P49902,Q8NCG7,P0DP25,P32119,P49354,P16435,Q14739,Q9UPU5,Q9NWM8,Q10472,Q13395,Q9NRN7,Q13315,P48729,Q9HC38,Q9NSD9,P10253,Q15067,Q16836,Q70CQ2,Q9BTY2,Q96AY3,Q9BT22,Q07864,P51571,P15289,Q96IX5,P55011,P50750,P14854,P06280,O95864,Q9BQT8,Q2TAA5,Q15043,O43708,O15228,Q15904,Q9UBM7,Q96QU8,P48651,P08183,Q96N66,Q6UX53,P56385,P21964,P04818,O15269,Q99426,Q9Y6M9,Q9BTU6,Q16763,Q14197,O14965,O75845,P22830,P49327,P78527,P51970,P50570,O14929,O43808,O00767 174 +FDA approved drug targets 0.4297552537466921 2.4721006262833627 0.0134321701892938 0.2369745986052971 0.0298492670873197 125 P54646,Q13423,P55011,Q14534,Q16850,P38435,O95864,P20020,Q8N0U8,Q99720,P31939,Q16134,P42574,Q9UGN5,Q9UBN7,P49354,P00374,P49721,P12235,P23786,P21964,P04818,P03886,P14735,P28074,P12236,P49356,P10253,P05067,P42345,P49327,Q16836,P05141,P39023,P16615,Q07864 36 +Potential drug targets 0.2877888996633393 1.2092006585903885 0.2265857647681124 0.9941353347756456 0.3485934842586345 526 Q15392,Q13546,P53985,Q16740,Q2M389,P09601,P07099,P51812,Q14108,Q8NAT1,Q7L592,Q9H061,Q8N511,Q9UM00,P16278,Q9UL01,P52429,O76094,P50897,O95470,P04062,P07602,P51648,O75844,Q13126,Q03518,Q06136,Q70HW3,O15118,Q15800,P22695,O14773,P10619,Q9H2D1,P37268,P54802,O43772,Q13510,P42892,Q9Y287,P13073,P48449,P11117,P47985,Q03519,P13473,O00116,P00403,Q96PC5,O14678,Q13535,P49748,Q96L58,P28340,Q03164,Q6P4A7,Q9Y619,Q8IV08,P49915,Q8TBA6,P21912,Q96RL7,P49902,P16435,Q14739,Q96A33,Q9NWM8,Q16625,Q13315,Q9P2D1,P51798,Q9NSD9,Q15067,Q96AY3,Q8TAA9,Q9BT22,Q99797,P15289,P50750,P06280,Q9BQT8,Q2TAA5,Q15043,O43708,O15228,Q15904,Q9UBM7,P48651,Q96N66,O15269,O76024,Q6ZXV5,O75845,P22830,P78527,P50570,Q96GX5 97 +Enzymes 0.2604904045117489 0.6823964980827034 0.4949882695088434 0.9999988357953704 0.6187353368860543 1004 P30519,Q15392,Q969T7,Q16740,Q15165,Q8N4Q0,P09601,P07099,P51812,P67812,Q9H8H2,P16278,Q9NPH0,P42785,Q9H3G5,P00374,P50897,P49721,Q9HB40,Q96G23,P23786,O95470,P04062,Q7Z478,P03886,Q9NUJ1,P51648,O75844,Q13126,Q8NCC3,Q06136,Q9Y680,Q9H7B4,Q9UHG3,Q15800,P78417,P22695,Q86UY6,O14773,Q8TBX8,P10619,O15217,P37268,P54802,P55786,Q13423,P43490,Q9BRR6,O60725,Q9UIQ6,Q16850,P38435,O95302,Q8N0U8,Q8N4A0,P31939,Q13510,P42892,O76062,P60900,Q6P2P2,Q9H7Z7,Q9UGN5,Q06520,P48449,Q86YN1,P11117,Q9H773,P47985,O95628,P28072,Q53GQ0,O00116,P00403,P49356,Q15418,O60502,Q13535,O60512,P49748,Q96L58,Q9NUQ2,P52789,P28340,Q03164,P16615,P54646,Q14534,Q8IV08,Q8TCT9,Q9H2U1,P20020,P49915,P21912,P49902,Q8NCG7,P32119,P49354,P16435,Q14739,Q9UPU5,Q9NWM8,Q10472,Q9NRN7,P14735,Q13315,Q9P2D1,P28074,P48729,Q9NSD9,P10253,O95881,Q15067,P42345,Q16836,Q70CQ2,Q9BRF8,Q9BTY2,Q96AY3,Q9BT22,Q99797,Q6NUM9,Q9NZ08,Q07864 124 +Disease related genes 0.2456468844600816 0.325868510502354 0.7445238413406232 0.9999999999985972 0.748652526755615 1119 Q15392,Q9UHX1,Q16740,P09601,P07099,P51812,Q13426,Q14108,Q99720,O43676,Q9H061,Q8N511,P16278,P00374,P50897,Q9Y584,P23786,O95470,P04062,P03886,Q9Y2R0,P07602,P51648,O75844,O14949,Q13126,Q03518,Q06136,Q15427,Q9Y487,Q70HW3,O15118,Q15800,P17900,P22695,O14773,Q15907,P10619,O75503,Q9H2D1,P37268,P54802,Q13432,Q13423,O95684,Q86XL3,P38435,Q9P0J0,O43772,P31939,Q13510,P42892,Q9Y287,O43292,P13073,P48449,P12235,P11117,Q86Y39,P47985,Q9NWS8,P42766,Q03519,P13473,O00116,Q8N5M9,P00403,Q96PC5,P05067,O14678,Q13535,P49748,Q96L58,P62847,P27544,P28340,Q03164,O43505,Q6P4A7,P16615,Q7KZN9,P42858,Q96CU9,Q96MG7,Q5HYI8,Q9Y619,Q9Y4P3,O43572,Q8IV08,P10412,P49915,Q6DKK2,Q96HY6,Q8TBA6,P21912,Q96RL7,P49902,Q9Y6B6,P0DP25,Q6PGP7,P16435,Q14739,O15360,Q96A33,Q9NWM8,Q16625,Q13315,Q99959,P62424,Q9P2D1,P51798,Q9NSD9,Q8TB36,P10253,Q15067,P42345,Q16836,Q5XKP0,Q96AY3,Q8TAA9,Q92733,Q9BT22,Q9NPL8,Q99797,Q9NVI7,Q07864,P51571,P15289,Q15154,Q6PJG6,Q9P032,Q96IX5,P50750,P14854,P06280,Q9H9S5,Q9BQT8,Q9BQS8,Q2TAA5,Q15043,Q15041,Q92974,O95613,O43708,O15228,Q15904,Q9UBN7,Q9UBM7,Q14691,P49770,P48651,P42695 152 +Human disease related genes 0.2511649242499808 0.3204166219300074 0.748652526755615 0.9999999999989873 0.748652526755615 1004 Q15392,Q9UHX1,Q16740,Q9BQE5,P09601,P07099,P51812,Q13426,Q14108,Q99720,O43676,Q9H061,Q8N511,P16278,Q9UBX3,P00374,P50897,Q9Y584,P23786,O95470,P04062,P03886,P07602,P51648,O75844,O14949,Q03518,Q06136,Q15427,Q9Y487,Q70HW3,O15118,Q15800,P17900,P22695,O14773,Q15907,P10619,O75503,P54802,Q13423,Q86XL3,P38435,Q9P0J0,O43772,O95202,P31939,Q13510,P42892,Q9Y287,Q9H7Z7,O43292,P48449,P12235,P11117,Q86Y39,Q9NWS8,P42766,Q03519,P13473,O00116,P00403,P05067,O14678,Q13535,P49748,Q96L58,P62847,P27544,Q03164,O43505,Q6P4A7,P16615,Q7KZN9,P42858,Q96CU9,Q9Y619,Q9Y4P3,Q8IV08,Q6DKK2,Q96HY6,P21912,Q96RL7,P49902,Q9Y6B6,Q9NR77,P0DP25,Q6PGP7,P16435,Q14739,O15360,Q9NWM8,Q16625,Q13315,Q99959,Q9P2D1,P51798,Q9NSD9,Q8TB36,P10253,Q15067,P42345,Q16836,Q5XKP0,Q96AY3,Q8TAA9,Q07812,Q9BT22,Q9NPL8,Q99797,Q9NVI7,Q07864,P51571,P15289,Q6PJG6,Q9P032,Q96IX5,P14854,P06280,Q9Y2G8,Q9H9S5,Q9BQT8,Q9BQS8,Q2TAA5,Q15043,Q15041,Q92974,O95613,O15228,Q9UBN7,Q9UBM7,P49770,P48651,P42695 134 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..87a6d9a940f293651f173797e1cf01f2e28cf852 --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAGAB", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABAT", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADAR", "ADD1", "ADD2", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADO", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGAP3", "AGK", "AGL", "AGPAT1", "AGPAT4", "AGPAT5", "AGPS", "AGTPBP1", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AK6", "AKAP1", "AKAP10", "AKAP12", "AKAP13", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "ALDH16A1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG11", "ALG2", "ALKBH5", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANKRD17", "ANKS1A", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APBB1", "APEH", "APEX1", "API5", "APIP", "APMAP", "APOL2", "APOO", "APOOL", "APP", "APRT", "AQR", "ARAP1", "ARCN1", "ARF4", "ARF5", "ARF6", "ARFGAP1", "ARFGAP2", "ARFGAP3", "ARFIP1", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGAP18", "ARHGDIA", "ARHGEF1", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID2", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL15", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARL8A", "ARL8B", "ARMC1", "ARMC10", "ARMC6", "ARMC8", "ARMC9", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARRB2", "ARSA", "ARVCF", "AS3MT", "ASAH1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATE1", "ATG3", "ATG4B", "ATG7", "ATG9A", "ATIC", "ATL2", "ATL3", "ATM", "ATP13A1", "ATP1A1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATR", "ATXN10", "ATXN2L", "AUP1", "AURKA", "AURKB", "B3GALT6", "B4GALT3", "B4GAT1", "BABAM1", "BABAM2", "BAG2", "BAG3", "BAG4", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAP18", "BARD1", "BAX", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAS3", "BCAT1", "BCAT2", "BCCIP", "BCKDHB", "BCKDK", "BCL2L13", "BCLAF1", "BCR", "BCS1L", "BDH2", "BECN1", "BEND3", "BICD2", "BIRC6", "BLM", "BLMH", "BLOC1S1", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C21orf59", "C2CD2L", "C2CD5", "C2orf49", "C3orf58", "C5orf51", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALM3", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CASP7", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CD3EAP", "CDC16", "CDC23", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC42BPB", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK5RAP3", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CEP170", "CEP250", "CEP290", "CEP44", "CEP55", "CEP97", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHERP", "CHID1", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHTF8", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCC1", "CLCN7", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLSTN3", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMBL", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT4", "CNOT7", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG5", "COG7", "COG8", "COIL", "COLGALT1", "COMMD2", "COMMD7", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COPZ1", "COQ8A", "CORO1B", "CORO1C", "CORO7", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6B1", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRK", "CRKL", "CRNKL1", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF15", "DCAF16", "DCAF7", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENND5B", "DENR", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH1", "DPH2", "DPH5", "DPM1", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSE", "DSG2", "DSP", "DST", "DSTN", "DTL", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFHD2", "EFL1", "EFR3A", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENDOG", "ENO1", "ENO2", "ENSA", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHX1", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESPL1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC5", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EXTL3", "EYA4", "EZR", "FABP5", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM105A", "FAM114A2", "FAM120A", "FAM120B", "FAM126A", "FAM129B", "FAM136A", "FAM162A", "FAM208A", "FAM20B", "FAM213A", "FAM49B", "FAM50A", "FAM83D", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXL18", "FBXO22", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FLYWCH1", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FSD1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALE", "GALK1", "GALNT1", "GALNT2", "GALNT4", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GEMIN6", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GID8", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMPPA", "GMPPB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNE", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOT1", "GOT2", "GPAA1", "GPATCH8", "GPD1L", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR180", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTA4", "GSTCD", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GTPBP6", "GTPBP8", "GTSE1", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAGH", "HARS2", "HAT1", "HAUS3", "HAUS4", "HAUS5", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HECTD3", "HELLS", "HELZ", "HERC2", "HEXA", "HEXB", "HGH1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOOK1", "HP1BP3", "HPF1", "HPRT1", "HPS5", "HS1BP3", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSD17B7", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IAH1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IFT52", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS4", "INTS6", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRGQ", "IRS4", "ISCA2", "ISG20L2", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGA6", "ITGAV", "ITGB1", "ITM2B", "ITM2C", "ITPA", "ITPK1", "ITSN2", "IVD", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1211", "KIAA1468", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMC1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLGL1", "LLPH", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LPCAT4", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC14", "LRRC40", "LRRC41", "LRRC47", "LRRC57", "LRRC59", "LRRC8A", "LRRFIP1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MACF1", "MAGED1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP4K4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MARS2", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCRS1", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL13", "METTL25", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD10", "MFSD3", "MFSD5", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOCS3", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPDZ", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL16", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL50", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS17", "MRPS18A", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS30", "MRPS31", "MRPS33", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTMR6", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND1", "NDC1", "NDC80", "NDRG1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB1", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NET1", "NEU1", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIF3L1", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OTULIN", "OXA1L", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAWR", "PAXBP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCNT", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PDXDC1", "PDXP", "PEBP1", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHLDB2", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R2", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLCG2", "PLD3", "PLD6", "PLEC", "PLEKHA5", "PLEKHA7", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLPBP", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PMVK", "PNKP", "PNN", "PNO1", "PNP", "PNPLA4", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMGNT2", "POMP", "PON2", "POP1", "POR", "POU2F1", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPFIBP1", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1CC", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGGTA", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REL", "RELA", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RGS10", "RHBDD2", "RHEB", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RP2", "RPA1", "RPA2", "RPA3", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SACS", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SCYL2", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEL1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SH3RF1", "SHCBP1", "SHMT1", "SHMT2", "SHPRH", "SHTN1", "SIGMAR1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A2", "SLC27A4", "SLC29A1", "SLC2A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLMAP", "SLTM", "SLU7", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMIM12", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SMYD4", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNTB2", "SNU13", "SNW1", "SNX1", "SNX12", "SNX14", "SNX2", "SNX27", "SNX3", "SNX4", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPR", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", 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"TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TCP11L1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TENM3", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THNSL1", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM22", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMM9", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TM7SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM160", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM33", "TMEM43", "TMEM87A", "TMEM97", "TMLHE", "TMOD1", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPMT", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC13", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPYL1", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC26", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF2", "TWISTNB", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", 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"ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCB8", "ABCD4", "ABHD10", "ACADVL", "ACOX1", "ACP2", "ACP6", "ADPGK", "AGPAT5", "AGPS", "AKAP10", "ALDH3A2", "ALG1", "ALG11", "ANKLE2", "APOL2", "APOO", "APP", "ARHGEF2", "ARL6IP1", "ARSA", "ASAH1", "ASNA1", "ATAD3A", "ATG9A", "ATIC", "ATL2", "ATM", "ATP13A1", "ATP2A2", "ATP2B1", "ATP5F1", "ATP5I", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATR", "AURKA", "B3GALT6", "B4GALT3", "B4GAT1", "BAX", "BCL2L13", "BRAT1", "BRI3BP", "BSG", "C19orf70", "CALM3", "CASP3", "CCDC47", "CCNB1", "CCNB2", "CDK9", "CERS1", "CERS2", "CHD7", "CISD1", "CKAP4", "CLCN7", "CLN5", "CLPP", "CLPTM1", "CLPTM1L", "CNNM3", "CNOT4", "COA3", "COMT", "COX15", "COX2", "COX4I1", "COX6B1", "CPPED1", "CPT2", "CPVL", "CSE1L", "CSNK1A1", "CTSA", "CYB5B", "CYB5D2", "CYP20A1", "CYP51A1", "DAGLB", "DCAKD", "DCTPP1", "DDRGK1", "DDX31", "DERL1", "DGKE", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHX29", "DHX36", "DNAJC1", 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0.4161874156663988 0.000785324268733 0.0002738812162273 0.0014550477007088 0.0001193580528442 0.0030799131207937 +Endoplasmic reticulum 87 204 4.673782937916356 2.957018557792068e-06 55.37621359223301 196.57766990291265 1.2201083743235763 0.4903523338807414 18.868778270733547 13.264167600850914 1.8573715045605257 0.4308007257692164 2.3228988087379056e-05 0.0068726499234184 5.618637057979553e-06 5.826115102326309e-13 6.995391961412406e-21 +Vesicles 63 328 3.2487712870156726 0.001159046287986 63.69174757281554 303.19174757281553 0.3021616120018026 0.6308308858815788 16.21576692438533 35.60761931464484 1.2670437076534344 0.3993041904676221 0.0293438261663593 0.1232925057890621 0.0338664998193364 0.004637567769795 0.0912627696643855 +Mitochondria 77 426 2.689699208544578 0.0071516448154962 110.1747572815534 400.5485436893204 0.4320244196044261 0.5794127039570083 42.49664228528663 36.15232166758906 2.0400795827803786 0.4211568684384254 0.0097391626412877 0.1287214746566994 0.0005148383636847 5.29493734656632e-10 3.1117297300321604e-11 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..05af60eae1ac15f8ed14733eb4ab95fb81462419 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3430, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 161.33333333333334 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..934d5a93262d059eafb3214541a5686259706944 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C007/C007_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..37a0c1e7066c434c00986180cef7d23ef3620a22 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,11 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Golgi apparatus 0.5422080633035787 4.718851700677627 2.3717963770764072e-06 7.82663102956163e-05 4.8790806203585626e-05 183 P80303,Q9HD45,P54646,P24390,Q93050,Q9H4A6,Q8N4Q0,P09601,O95302,Q9H2V7,O00461,Q8N4A0,O60637,Q8TBA6,Q9BRK5,P55327,P67812,Q02818,Q9H8H2,P16278,O15127,Q9Y287,Q13190,Q5VW38,Q8IXU6,P50897,Q9HB40,Q9NPR9,P49755,Q9NWM8,A1L0T0,P53367,Q8NBN3,Q9UBU6,O75071,P05067,Q13535,O60512,Q8IZA0 39 +Endoplasmic reticulum 0.5366449182640295 4.673782937916356 2.957018557792068e-06 9.757699573801812e-05 4.8790806203585626e-05 204 O60831,O43169,Q9P035,P43307,Q5BJF2,Q9UM00,O95197,Q14849,Q9H3G5,Q96GC9,Q8NF37,O43731,Q96G23,O95470,Q8WUJ1,P27635,Q86UE4,P62917,P51648,Q03518,Q9Y680,Q15800,P50402,Q9P2W9,P37268,Q9NQC3,Q86XL3,P46778,P26373,Q16850,P13674,Q8N0U8,Q9NZ01,P67809,P62820,P20042,O76062,Q9HCU5,O43292,O96005,P14859,Q5T9L3,Q96AG4,P42766,Q03519,Q15631,Q96KC8,P27824,P61513,Q9BUN8,O00264,Q99735,Q96PC5,P62277,P36578,Q14257,P62847,P27544,Q9NR31,P62750,Q5HYI8,Q8IV08,Q8TCT9,Q96HY6,P62841,Q9Y6B6,Q96KA5,Q96A33,O15260,Q96CN7,Q9BT22,P51571,Q15043,Q8NHH9,Q9H3N1,Q15041,Q9Y3U8,Q9UBM7,P48651,P83731,P21964,O15269,Q13409,P62266,P47914,O75845,O00767 87 +Vesicles 0.4043417068454689 3.2487712870156726 0.001159046287986 0.0375476403886653 0.0127495091678462 328 P35613,P30519,Q9HD45,P24390,Q13277,Q8IXH7,Q8NBX0,Q93050,Q9HD20,P55011,Q9Y5X3,Q9H4A6,Q14534,Q8N4Q0,Q9Y2G8,O95302,Q9H2V7,Q96SK2,O15127,O76062,Q9H8H2,P16278,Q9Y287,Q8TB61,Q86V85,Q9NUD5,Q14849,Q92564,P42785,Q96P70,P50897,Q86YN1,P16435,Q96ES6,Q9NPR9,O75153,P14859,Q9NRY5,P13473,A1L0T0,Q8WTV0,Q13315,P07602,P62424,P53367,Q8N5M9,Q8NCC3,Q96CN7,Q9BSH5,Q9Y487,P10253,P05067,O15118,P42345,P17900,Q3SXM5,P52789,Q15907,P10619,P35269,Q15363,Q96KP1,Q6P4A7 63 +Mitochondria 0.3465321207598379 2.689699208544578 0.0071516448154962 0.2108921169390092 0.0472008557822751 426 Q9NS69,Q16740,Q69YU5,P45880,Q8N4H5,O60830,O75964,Q9UBX3,P00374,Q99595,P23786,Q9BXK5,Q13505,Q9Y2R0,Q9NUJ1,Q8WY22,O14949,Q96A26,Q70HW3,Q9UDX5,P22695,Q3SXM5,Q9H2D1,O14925,Q15070,Q13423,Q8NAN2,O95302,Q9P0J0,O43772,O95202,P57105,Q9Y6C9,Q9H4I3,Q9H7Z7,Q7LGA3,O43292,P13073,Q96EX1,P24539,P12235,Q86Y39,P47985,Q9NWS8,Q7Z7H8,Q9Y5L4,P12236,Q9NZ45,Q9NX40,P49748,Q9NUQ2,P52789,Q6P4A7,Q8IYU8,Q7KZN9,Q96CU9,Q9BUR5,Q9H2U1,Q6DKK2,Q7Z4V5,P21912,Q9Y277,Q96NB2,Q8TB36,Q15388,Q16836,Q5XKP0,Q96AY3,Q9NPL8,Q99797,Q8TAE8,Q99623,Q9NVI7,Q9P032,Q9NUT2,Q9NQ29,Q96IX5 77 +Centriolar satellite 0.4943416328865109 1.8625264302284188 0.0625289235267072 0.8812564699552634 0.1587272674139491 35 O43169,P41208,Q86UY6,Q03518 4 +Lipid droplets 0.5107859179294229 0.9508184136344464 0.3416965634904629 0.9999989812631088 0.5125448452356944 9 Q01105,Q969V3 2 +Lysosomes 0.4091156629113066 0.541978512721061 0.5878333083457488 0.9999999999998016 0.7535558642753518 13 O15400,Q8IY95,Q8WTV0,P02786,O60749 5 +Nuclear membrane 0.31069756600713 0.5334665200123277 0.5937106809442165 0.9999999999998764 0.7535558642753518 67 P67812,Q13277,Q9H1E5,Q9BTX1,O94919,Q14739,Q96SK2,Q96G23,Q8IXM6 9 +Centrosome 0.3003764196839759 0.4400347975207953 0.6599119047219273 0.9999999999999996 0.8065589946601333 76 Q9UJW0,O95613,Q3B7T1,Q69YU5,O95684,Q9BRR6,Q96DB5,P52789,Q9BRT9,O43292,P28074,Q96SN8,P43034,P49356,Q96LJ7,O14777,O14965 17 +Peroxisomes 0.3168515903229187 0.1136881413465385 0.909485013402564 1.0 1.0 13 Q15067,O75381,O00116,Q8WVX9,O43808 5 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..46c5ce82bed858a244fd03186de94e6e49dff636 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAGAB", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABAT", "ABCB1", "ABCB7", "ABCB8", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABHD6", "ABI1", "ABRAXAS2", "ABT1", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAP2", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ADAR", "ADD1", "ADD2", "ADD3", 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"BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRAT1", "BRCA1", "BRD2", "BRD4", "BRD8", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSDC1", "BSG", "BTAF1", "BTF3", "BUB1", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf73", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD2L", "C2CD5", "C2orf49", "C5orf51", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALR", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAND1", "CAND2", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPNS1", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CASP3", "CAST", "CBFB", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CC2D1A", "CCAR1", "CCAR2", "CCDC115", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC58", "CCDC6", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD109", "CD2AP", "CD2BP2", "CD3EAP", "CDC25C", "CDC27", "CDC37", "CDC40", "CDC42", "CDC5L", "CDC6", "CDC73", "CDCA2", "CDCA7L", "CDCA8", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK5RAP3", "CDK9", "CDKN2AIP", "CEBPZ", "CECR2", "CELF1", "CELF2", "CENPB", "CENPF", "CENPU", "CENPV", "CEP170", "CEP250", "CEP290", "CEP55", "CERS1", "CERS2", "CETN2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHD8", "CHEK1", "CHEK2", "CHID1", "CHM", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHTF18", "CHUK", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIT", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLASP2", "CLCC1", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLIP1", "CLK3", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT10", "CNOT11", "CNOT3", "CNOT7", "CNP", "CNPY2", "COA3", "COA7", "COG5", "COG7", "COG8", "COIL", "COLGALT1", "COMMD7", "COMMD8", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS7B", "COPS8", "COQ8A", "CORO1B", "COTL1", "COX15", "COX4I1", "COX5B", "COX6B1", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPPED1", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CREBBP", "CRK", "CRKL", "CROT", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A1", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDP1", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CUTA", "CUTC", "CWC22", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAGLB", "DAP3", "DARS", "DARS2", "DAXX", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF15", "DCAF16", "DCAF7", "DCAKD", "DCP1A", "DCP1B", "DCPS", "DCTD", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCUN1D4", "DCUN1D5", "DCXR", "DDA1", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDT", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX31", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENND5B", "DENR", "DERA", "DERL1", "DERL2", "DFFA", "DGKE", "DHCR7", "DHFR", "DHRS1", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIMT1", "DIP2A", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNAAF2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB6", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DOLPP1", "DPF2", "DPH1", "DPH2", "DPH5", "DPP3", "DPP9", "DPY30", "DPYSL2", "DPYSL3", "DPYSL5", "DR1", "DRG1", "DRG2", "DSC2", "DSG2", "DSP", "DST", "DTL", "DTYMK", "DUS2", "DUS3L", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "ECT2", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFCAB14", "EFHD2", "EFL1", "EFR3A", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELF2", "ELMO2", "ELMOD2", "ELOA", "ELP1", "ELP2", "ELP3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "ENY2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPN1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERBIN", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESPL1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETHE1", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC4", "EXOC6B", "EXOC7", "EXOC8", "EXOG", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC7", "EXOSC8", "EXOSC9", "EYA4", "EZR", "FABP5", "FAF1", "FAF2", "FAH", "FAHD1", "FAM105A", "FAM114A2", "FAM120A", "FAM120B", "FAM126A", "FAM129B", "FAM136A", "FAM162A", "FAM208A", "FAM20B", "FAM49B", "FAM50A", "FAM83D", "FAM8A1", "FAM91A1", "FAM98A", "FAM98B", "FANCA", "FANCD2", "FANCI", "FAR1", "FAR2", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXL18", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP15", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FKBP9", "FKRP", "FLAD1", "FLCN", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FLYWCH1", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOCAD", "FOXC1", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ1", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "FYCO1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALE", "GALK1", "GALNT2", "GALNT4", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBE1", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GEMIN6", "GET4", "GFM1", "GFPT1", "GGA1", "GGA2", "GHITM", "GID8", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLT8D1", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNB1", "GNB1L", "GNE", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLIM4", "GOLPH3", "GOLT1B", "GORASP2", "GOT1", "GPAA1", "GPATCH8", "GPD2", "GPHN", "GPI", "GPKOW", "GPR107", "GPR108", "GPR180", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSPT1", "GSR", "GSS", "GSTCD", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E2", "GTF2F1", "GTF2F2", "GTF2H1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GTPBP6", "GTPBP8", "GTSE1", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H3-3A*", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS3", "HAUS6", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDAC6", "HDDC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HERC2", "HEXA", "HGH1", "HGS", "HIBCH", "HINT2", "HIP1", "HIP1R", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMG20A", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMMR", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HPS5", "HS1BP3", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "IAH1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IFIT5", "IFT52", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKB", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INPPL1", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "INTS4", "INTS6", "INTS7", "INTS8", "INTS9", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRAK1", "IRF2BP1", "IRF2BPL", "IRGQ", "ISG20L2", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGAV", "ITGB1", "ITM2B", "ITPA", "ITPK1", "ITSN2", "IVD", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KATNB1", "KCTD10", "KCTD12", "KDELC2", "KDELR1", "KDELR3", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1211", "KIAA1468", "KIDINS220", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "KIN", "KLC1", "KLC2", "KLC4", "KMT2A", "KNSTRN", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMC1", "LAMP2", "LAMTOR1", "LAMTOR2", "LANCL2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIN28B", "LIN9", "LIPA", "LLPH", "LMAN1", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRCH2", "LRP1", "LRPAP1", "LRPPRC", "LRRC1", "LRRC14", "LRRC40", "LRRC41", "LRRC47", "LRRC57", "LRRC59", "LRRFIP1", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSM7", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "MACF1", "MAGED1", "MAGED2", "MAIP1", "MAK16", "MAN1A2", "MAN2A1", "MAN2B1", "MAP1A", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAPK1", "MAPK3", "MAPKAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MASTL", "MAT2A", "MAT2B", "MATR3", "MAU2", "MAVS", "MBD1", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM3AP", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCRS1", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MECR", "MED1", "MED14", "MED16", "MED17", "MED21", "MED23", "MED4", "MEPCE", "MESD", "METAP2", "METTL13", "METTL25", "METTL7B", "MFAP1", "MFGE8", "MFN1", "MFSD10", "MFSD3", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICAL3", "MICALL1", "MICU2", "MID1", "MIEF1", "MIF", "MIGA1", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMACHC", "MMS19", "MOCS1", "MOGS", "MON2", "MORC2", "MORC3", "MORF4L1", "MOSPD2", "MOV10", "MPHOSPH10", "MPHOSPH6", "MPI", "MPP1", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRGBP", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL44", "MRPL46", "MRPL47", "MRPL50", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS16", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTERF3", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFR", "MTIF2", "MTMR2", "MTO1", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAM1", "NCAPD2", "NCAPD3", "NCAPG2", "NCAPH", "NCBP1", "NCBP2", "NCBP3", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDC80", "NDRG1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF2", "NDUFAF4", "NDUFB1", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4", "NEFL", "NEFM", "NELFCD", "NELFE", "NEMF", "NES", "NET1", "NEU1", "NF1", "NFATC2IP", "NHLRC2", "NIF3L1", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NMD3", "NME1", "NME3", "NME7", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOP9", "NOSIP", "NOTCH2", "NPAT", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSRP1", "NSUN2", "NSUN5", "NT5C3A", "NT5DC1", "NTPCR", "NUB1", "NUBP2", "NUBPL", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGFOD1", "OGFR", "OGT", "OLA1", "OPA1", "ORC3", "OS9", "OSBP", "OSBPL11", "OSBPL1A", "OSBPL2", "OSBPL8", "OSBPL9", "OTUB1", "OTUD7B", "OTULIN", "OXA1L", "OXCT1", "OXSM", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP1", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARD3", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PARS2", "PATL1", "PAWR", "PAXBP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCNT", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDSS1", "PDSS2", "PDXDC1", "PEBP1", "PEF1", "PELO", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PEX5", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF2", "PHF3", "PHF6", "PHGDH", "PHIP", "PHLDB2", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGU", "PIH1D1", "PIK3C2A", "PIK3R4", "PIN4", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN1", "PKN2", "PKP2", "PLA2G15", "PLAA", "PLCG1", "PLCG2", "PLD3", "PLEC", "PLEKHA5", "PLEKHA7", "PLIN3", "PLOD1", "PLOD2", "PLPBP", "PLRG1", "PLS3", "PM20D2", "PMF1", "PMPCA", "PMPCB", "PNKP", "PNN", "PNO1", "PNP", "PNPLA6", "PNPLA8", "PNPO", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLR3E", "POLRMT", "POMP", "POP1", "POR", "POU2F1", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPFIBP1", "PPIB", "PPID", "PPIE", "PPIF", "PPIL2", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP4R2", "PPP4R3A", "PPP5C", "PPP6R3", "PPT1", "PPWD1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCA", "PRKCB", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRMT9", "PRPF18", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS2", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRUNE1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMF1", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRICH1", "QRSL1", "QSOX2", "QTRT1", "QTRT2", "RAB11B", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB36", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAF1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RANGRF", "RAP1GDS1", "RAPGEF2", "RARS", "RARS2", "RASAL2", "RAVER1", "RB1", "RBBP4", "RBBP5", "RBBP6", "RBBP7", "RBBP9", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM15B", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDX", "RECQL", "REEP5", "RELA", "REPS1", "RER1", "RETREG3", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RFLNB", "RGS10", "RHBDD2", "RHOA", "RHOT2", "RIC8A", "RIF1", "RINT1", "RIOK1", "RIOK2", "RIOX2", "RIPK1", "RMC1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASEH2B", "RNF2", "RNF20", "RNF213", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA2", "RPAP1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP14", "RPP25L", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SAR1B", "SARM1", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SATB2", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL1", "SDAD1", "SDCBP", "SDE2", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETD1A", "SETD2", "SETD3", "SETD7", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B5", "SF3B6", "SFMBT1", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGK3", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SH3RF1", "SHCBP1", "SHMT1", "SHMT2", "SHPRH", "SHTN1", "SIN3A", "SIPA1", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLFN11", "SLIRP", "SLK", "SLMAP", "SLTM", "SLU7", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMIM12", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SMYD3", "SMYD4", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNTB2", "SNW1", "SNX1", "SNX14", "SNX2", "SNX27", "SNX5", "SNX6", "SNX8", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPDL1", "SPECC1", "SPECC1L", "SPEN", "SPNS1", "SPR", "SPRYD4", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SRA1", "SRBD1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK4", "STMN1", "STOML2", "STRAP", "STRIP1", "STRN", "STT3B", "STUB1", "STX12", "STX18", "STX3", "STX5", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP2", "SUGT1", "SULT2A1", "SUMO2", "SUN1", "SUN2", "SUPT16H", "SUPT20H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TAP1", "TAP2", "TARBP1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP11L1", "TDP2", "TDRKH", "TECR", "TEFM", "TELO2", "TENM3", "TERF2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB2M", "TFCP2", "TFG", "TFIP11", "TFRC", "TGFBRAP1", "THADA", "THNSL1", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM9", "TIMMDC1", "TJP1", "TJP2", "TKFC", "TKT", "TLN1", "TM7SF2", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM109", "TMEM126A", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM87A", "TMEM97", "TMLHE", "TMOD3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO2", "TNPO3", "TNRC6A", "TOE1", "TOM1", "TOM1L2", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TONSL", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1A", "TOR1AIP1", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAF2", "TRAP1", "TRAPPC11", "TRAPPC13", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM25", "TRIM26", "TRIM27", "TRIM28", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT61A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSN", "TSNAX", "TSPAN3", "TSPAN6", "TSPYL1", "TSR1", "TST", "TSTA3", "TTC1", "TTC19", "TTC27", "TTC28", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF2", "TWISTNB", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYSND1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2Q1", "UBE2S", "UBE2T", "UBE3A", "UBE3C", "UBE4A", "UBL7", "UBP1", "UBQLN4", "UBR1", "UBR2", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCC1", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP24", "USP28", "USP32", "USP34", "USP39", "USP4", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "UXT", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VASP", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13C", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS45", "VPS4A", "VPS4B", "VPS51", "VPS53", "VPS72", "VRK1", "VRK2", "VRK3", "WAPL", "WARS", "WASF2", "WASHC3", "WASHC4", "WASHC5", "WBP11", "WBP2", "WDCP", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR41", "WDR46", "WDR47", "WDR48", "WDR5", "WDR6", "WDR61", "WDR62", "WDR74", "WDR77", "WDR82", "WIPI2", "WLS", "WNK1", "WRAP53", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO6", "XPOT", "XRCC1", "XRCC4", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YES1", "YKT6", "YLPM1", "YME1L1", "YPEL5", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC11", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMAT2", "ZMYM2", "ZMYM3", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF622", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ABCB8", "ABHD10", "ACADVL", "ACOX1", "ADPGK", "AGPAT5", "AGPS", "ALDH3A2", "ALG1", "ANKLE2", "APOO", "APP", "ARFIP1", "ARL6IP1", "ATAD3A", "ATL2", "ATM", "ATP13A1", "ATP5F1", "ATP5L", "ATP6V0A1", "ATP6V0A2", "ATR", "AURKA", "B4GALT3", "BCL2L13", "BRI3BP", "BSG", "C12orf73", "C19orf70", "CANX", "CCDC47", "CDK5RAP2", "CERS1", "CERS2", "CETN2", "CISD1", "CLPP", "CLPTM1", "CLPTM1L", "CLUH", "COA3", "COMT", "COX15", "COX4I1", "CPT2", "CPVL", "CTSA", "CYB5B", "CYB5D2", "CYP51A1", "DCTN4", "DCUN1D4", "DDRGK1", "DDX31", "DERL1", "DHCR7", "DHFR", "DHRS1", "DHX36", "DNAJC1", "DNAJC16", "DOLPP1", "DYNC1I2", "EDRF1", "EFCAB14", "EIF2S2", "EMD", "ENDOD1", "EXOC2", "FAM114A2", "FAM162A", "FAM8A1", "FAR1", "FDFT1", "FGFR1OP", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "FNTB", "FOXRED1", "GAA", "GADD45GIP1", "GALNT4", "GDAP1", "GINS4", "GLB1", "GM2A", "GOLGA5", "GOLIM4", "GOLPH3", "GPAA1", "GPR107", "GPR108", "GPR180", "GTF2F1", "HACD3", "HADH", "HDGFL2", "HDHD3", "HK2", "HM13", "HMOX1", "HMOX2", "HS2ST1", "HSDL1", "ILVBL", "IPO9", "ISOC1", "ITM2B", "JAGN1", "KDELR1", "KDELR3", "KIAA0319L", "LAMP2", "LBR", "LETM1", "LPCAT1", "LRRC59", "LUC7L", "MFSD3", "MGST2", "MIA2", "MICU2", "MIGA1", "MIPEP", "MRPL10", "MSMO1", "MTCH2", "MTDH", "MTFP1", "MTOR", "MTX1", "NAA40", "NCLN", "NDC1", "NDC80", "NDUFA11", "NDUFA13", "NDUFAF4", "NELFCD", "NNT", "NPC1", "NRM", "NUCB1", "NUCB2", "OCIAD1", "OXA1L", "P4HA1", "PAFAH1B1", "PCNT", "PEX14", "PGRMC1", "PHB2", "PLA2G15", "PLD3", "POR", "POU2F1", "PPT1", "PRAF2", "PRCP", "PREB", "PRKAA2", "PSAP", "PSMB5", "PTDSS1", "PTGES2", "RAB11B", "RAB1A", "RABL3", "RCN2", "RMDN1", "RMND1", "RPL10", "RPL13", "RPL21", "RPL23A", "RPL24", "RPL29", "RPL35", "RPL36", "RPL37A", "RPL4", "RPL7A", "RPL8", "RPS13", "RPS15", "RPS23", "RPS24", "RTN3", "RTN4", "SAR1A", "SAR1B", "SC5D", "SCAMP2", "SCARB1", "SCCPDH", "SCD", "SCPEP1", "SDF4", "SDHB", "SEC11A", "SET", "SFXN2", "SFXN4", "SGPL1", "SLC12A2", "SLC25A10", "SLC25A17", "SLC25A20", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A6", "SLC35B2", "SLC35F2", "SLC39A14", "SMIM12", "SNX2", "SNX5", "SPNS1", "SPTLC1", "SQLE", "SSR1", "SSR4", "STARD3", "STX18", "STX3", "STX5", "STX7", "SURF4", "SYNJ2BP", "TAP1", "TAP2", "TECR", "TFRC", "TIMM13", "TIMM17A", "TIMM17B", "TIMM23", "TIMMDC1", "TM7SF2", "TM9SF3", "TMCO1", "TMED10", "TMED2", "TMEM192", "TMEM209", "TMEM87A", "TMEM97", "TMX1", "TMX4", "TOMM20", "TOMM22", "TOMM5", "TPD52", "TRABD", "TSN", "TSPAN3", "TTC19", "UQCRC2", "UQCRFS1", "UQCRQ", "USMG5", "VDAC2", "VDAC3", "VKORC1L1", "VMP1", "WLS", "YBX1", "ZADH2", "ZCCHC3"]} \ No newline at end of file