Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Glycerophospholipid biosynthesis 0.7105743095668672 2.900801265796092 0.0037220985548402 0.994535446116505 0.2919929843029585 31 Q96N66,Q8NCC3,Q8IV08,Q9NPH0,Q8N2A8,Q9NQZ5,Q9UG56,Q92604,P35790 9 Mitochondrial protein import 0.6543125471218227 2.533957433262783 0.0112782430998814 0.9999998686273226 0.3664117583845209 30 Q99595,Q13505,O60830,Q9NS69 4 Antigen processing cross presentation 0.5608592352906341 2.463650901936058 0.0137529989404954 0.9999999960370664 0.3921246365470864 50 P60900,P28074,P49721,Q12846,Q9UIQ6,P28072,P01889 7 Abc transporter disorders 0.5801834589367874 2.3376685216869673 0.0194044503312758 0.9999999999987076 0.4755792475928473 39 P60900,P28074,P20618,P49721,Q9BUN8,P28072,P61289 7 Defective cftr causes cystic fibrosis 0.5801834589367875 2.3376685216869673 0.0194044503312758 0.9999999999987076 0.4755792475928473 39 P60900,P28074,P20618,P49721,Q9BUN8,P28072,P61289 7 Rac3 gtpase cycle 0.6066894050289355 2.3136777284786683 0.0206854064524548 0.9999999999997918 0.4865161639005421 33 Q9UQB8,O15173,Q6IAA8,O75962,Q7L576,Q14739,Q9NRY4,P50402 8 Regulation of hmox1 expression and activity 0.5438857969377998 2.3102873878295385 0.0208722487132331 0.9999999999998406 0.4865161639005421 47 P60900,P28074,Q13309,Q8TCT9,P20618,P49721,P49720,P28072,P61289,P09601 10 Switching of origins to a post replicative state 0.5312525137815555 2.30986789940136 0.020895468743044 0.9999999999998458 0.4865161639005421 58 P60900,P28074,P30260,Q13309,P20618,P49721,Q99741,Q9UJX6,P49720,Q96DE5,P28072,Q9UBD5,P61289,P63208 14 Hedgehog on state 0.5555306306016657 2.2879213052820835 0.0221421043431531 0.999999999999974 0.489513347273987 42 P60900,P28074,P20618,P49721,Q9Y496,Q2M1P5,P28072,P61289 8 Phospholipid metabolism 0.5359857186472701 2.2831450814386427 0.022421823809601 0.9999999999999826 0.489513347273987 52 Q96N66,Q8NCC3,Q8IV08,Q9NPH0,Q8N2A8,Q9NQZ5,Q9UG56,Q92604,Q8N9F7,P42356,P35790 11 Cdt1 association with the cdc6 orc origin complex 0.5685892212821172 2.2554126529360405 0.0241074392744877 0.9999999999999984 0.516354598226986 39 P60900,P28074,P20618,P49721,Q99741,P49720,P28072,Q9UBD5,P61289 9 Hedgehog ligand biogenesis 0.5719058072182498 2.240855349567622 0.0250354462933573 0.9999999999999996 0.516354598226986 38 P60900,P28074,P20618,P49721,P07237,P28072,P61289 7 Deubiquitination 0.4606938622710159 2.233338879408672 0.0255266054570277 0.9999999999999998 0.516354598226986 100 P60900,P49721,Q9NWV8,Q9UPU5,Q15018,O94966,Q70CQ2,P61289,P28074,Q9NXR7,P28072,P45880,P20618,Q13309,Q99496,P21796,P49720,Q96K76,Q8TAF3 19 Abc family proteins mediated transport 0.5332237518297929 2.2266797605317707 0.0259686840411537 1.0 0.516354598226986 47 P60900,P28074,P20618,Q9NRK6,P49721,Q9BUN8,P28072 7 Dna replication 0.4464261503526278 2.2256103227905606 0.026040294151965 1.0 0.516354598226986 88 P60900,P49721,Q9NRF9,O60684,P61289,P63208,P28074,P16104,P30260,Q9BRX5,P35250,Q9UJX6,P62805,P35251,P28072,P20618,Q99741,Q9UBD5,Q96DE5,Q9UL46,Q9Y248,Q13309,P49720,Q14997 24 Ub specific processing proteases 0.4743456945814244 2.212487444530439 0.0269330027847032 1.0 0.516354598226986 78 P60900,Q70CQ2,P28074,Q13309,P21796,P20618,P49721,Q9UPU5,Q96K76,P28072,Q8TAF3,P45880 12 Runx1 regulates transcription of genes involved in differentiation of hscs 0.5437608108958941 2.1999063222532285 0.0278135420717631 1.0 0.5170425973522872 42 P60900,P28074,P16104,P20618,P49721,P62805,P28072,P61289 8 Orc1 removal from chromatin 0.5278629319013787 2.195492313899857 0.0281283016455073 1.0 0.5170425973522872 49 P60900,P28074,Q13309,P20618,P49721,Q99741,P49720,P28072,Q9UBD5,P61289,P63208 11 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.6856584473685704 2.1849900292343793 0.0288895776683635 1.0 0.5191134661789555 17 P05067,O43852,Q08431,P19022,Q02818 5 Asymmetric localization of pcp proteins 0.5676746318372948 2.1756317745948786 0.0295828054346638 1.0 0.5191134661789555 37 P60900,P28074,P20618,P49721,P28072,P61289 6 Degradation of axin 0.5704211697884601 2.161450225821581 0.0306605778972102 1.0 0.5191134661789555 36 P60900,P28074,P20618,P49721,P28072,P61289 6 Cross presentation of soluble exogenous antigens endosomes 0.5704211697884601 2.161450225821581 0.0306605778972102 1.0 0.5191134661789555 36 P60900,P28074,P20618,P49721,P28072,P61289 6 Pcp ce pathway 0.521277882569438 2.1321713551276225 0.0329927623783057 1.0 0.5215993517360871 47 P60900,P28074,P20618,P49721,P28072,P61289 6 Auf1 hnrnp d0 binds and destabilizes mrna 0.5398566471786747 2.127215709919855 0.033402164414054 1.0 0.5215993517360871 41 P60900,P28074,P20618,P49721,P28072,P61289 6 Regulation of ras by gaps 0.5604078140198925 2.1247989298573757 0.0336033941705424 1.0 0.5215993517360871 37 P60900,P28074,P20618,P49721,P28072,P61289 6 Degradation of dvl 0.5604078140198925 2.1247989298573757 0.0336033941705424 1.0 0.5215993517360871 37 P60900,P28074,P20618,P49721,P28072,P61289 6 Scf skp2 mediated degradation of p27 p21 0.541008459010795 2.0950522395943327 0.0361663489164705 1.0 0.5406418032264593 40 P60900,P28074,Q13309,P20618,P49721,P49720,P28072,P61289 8 Dna replication pre initiation 0.5006696882363473 2.0897007451427765 0.0366446900387835 1.0 0.5406418032264593 61 P60900,P28074,P16104,P20618,P49721,Q99741,P49720,P62805,P28072,O60684,Q9UBD5,Q14997,P61289 13 Dna damage telomere stress induced senescence 0.6663206986683174 2.085704517416777 0.0370053969940591 1.0 0.5406418032264593 17 P16104,P10412,P16402,P62805,P17096 5 G1 s dna damage checkpoints 0.5331903664109574 2.077455939217534 0.0377594978329784 1.0 0.5438146234295975 41 P60900,P28074,P20618,P49721,P28072,P61289 6 Rac1 gtpase cycle 0.5117108805816026 2.0604080130350644 0.0393595515082776 1.0 0.5554070046168066 48 Q9UQB8,Q9Y2I1,Q96F07,Q6IAA8,O75962,Q13459,Q7L576,Q14739,Q9NRY4,P50402,Q14185 11 Stabilization of p53 0.5371339413328872 2.02867491292351 0.0424914127545454 1.0 0.5681943428964192 39 P60900,P28074,P20618,P49721,P28072,P61289 6 Synthesis of dna 0.4407636279466718 2.0273796257579986 0.0426236039415857 1.0 0.5681943428964192 83 P60900,P49721,Q9NRF9,P61289,P63208,P28074,P30260,Q9BRX5,P35250,Q9UJX6,P35251,P28072,P20618,Q99741,Q9UBD5,Q96DE5,Q9UL46,Q9Y248,Q13309,P49720,Q14997 21 Regulation of runx3 expression and activity 0.5463532683481624 2.025737500527214 0.0427916916212207 1.0 0.5681943428964192 37 P60900,P28074,P20618,P49721,P28072,P61289 6 Sphingolipid de novo biosynthesis 0.7450494219223991 2.0098160417882234 0.0444506623117439 1.0 0.5749775486065404 10 O95470,Q96G23 2 Collagen biosynthesis and modifying enzymes 0.7164092144448946 1.99516502998746 0.0460248836983996 1.0 0.5840892038325959 11 O75718,Q32P28,P13674 3 Carnitine metabolism 0.8728998119869609 1.9947806465194324 0.0460668090637468 1.0 0.5840892038325959 5 O43772 1 Mapk6 mapk4 signaling 0.5029522872882324 1.985502221310075 0.0470886232270615 1.0 0.5840892038325959 47 P60900,P28074,P20618,P49721,P28072,P61289 6 Cellular response to hypoxia 0.5308884669229073 1.983042859529598 0.0473626423201387 1.0 0.5840892038325959 39 P60900,P28074,P20618,P49721,P28072,P61289 6 Hedgehog off state 0.4989796829579347 1.980354703834783 0.0476636859247787 1.0 0.5840892038325959 52 P60900,P28074,Q8NCM8,P20618,P49721,P48729,Q9UL46,Q9Y496,Q2M1P5,P49720,P68371,P28072,P04350,Q14997,P61289,P63208 16 Metabolism of polyamines 0.5329357075749492 1.962973745908811 0.0496492247368172 1.0 0.595610418791353 38 P60900,P28074,P20618,P49721,P28072,P61289 6 Heme degradation 0.9244392456936934 1.9587011417652904 0.0501477966612409 1.0 0.595610418791353 4 P30519 1 Regulation of pten stability and activity 0.5170583993390225 1.956038543195818 0.0504606138518353 1.0 0.595610418791353 41 P60900,P28074,P20618,P49721,P28072,P61289 6 Degradation of gli1 by the proteasome 0.5268880094128872 1.9537093091679976 0.0507356047503013 1.0 0.595610418791353 39 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Cristae formation 0.6220722867938097 1.9423853147873555 0.0520904717394838 1.0 0.6014081737194958 19 O75964,Q9NX63,P36542,Q13505,Q5XKP0,Q9BUR5 6 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.4942553413745117 1.9345364131040417 0.0530472095209513 1.0 0.6034286783040225 51 P60900,P28074,Q13309,P20618,P49721,Q9UJX6,P49720,Q96DE5,P28072,P61289 10 Negative regulation of notch4 signaling 0.5226617334504742 1.9226321801784896 0.0545262596169253 1.0 0.6034286783040225 39 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Synthesis of pa 0.7488221301391407 1.91908916164808 0.0549730508880812 1.0 0.6034286783040225 9 Q9NPH0 1 The role of gtse1 in g2 m progression after g2 checkpoint 0.4936587857653144 1.91862787629743 0.0550314450838054 1.0 0.6034286783040225 49 P60900,P28074,P20618,P49721,P28072,P04350,P61289 7 Amyloid fiber formation 0.7626279358992353 1.918079924439207 0.0551008775985861 1.0 0.6034286783040225 8 P62805,P16104,Q9UJY5,P05067 4 Mitophagy 0.7404031380525028 1.8831292685367669 0.0596828516175267 1.0 0.6034286783040225 9 Q9NS69 1 Metabolism of porphyrins 0.7676703240225176 1.8811807673864516 0.0599473330390605 1.0 0.6034286783040225 7 P30519 1 Rnd2 gtpase cycle 0.6160006381498571 1.8639415653852107 0.0623299108129351 1.0 0.6034286783040225 18 O43396,Q9NRY4,Q9Y2I1,Q9BTT6 4 Signaling by hedgehog 0.4798570063005322 1.85129621935879 0.0641269496963412 1.0 0.6034349240780601 56 P60900,P28074,Q8NCM8,P20618,P49721,P48729,Q9UL46,Q9Y496,P07237,Q2M1P5,P49720,P68371,P28072,P04350,Q14997,P61289,P63208 17 Uch proteinases 0.4852395270765038 1.8418531404501972 0.0654966345223118 1.0 0.6059523074680105 47 P60900,P28074,Q99496,P20618,P49721,P28072,P61289 7 Organelle biogenesis and maintenance 0.4182593632422597 1.836291789004314 0.0663145134990932 1.0 0.6094827326199556 94 O75964,Q9NX63,O00411,A6NIH7,A0AVF1,O94927,Q9Y496,O75935,Q99996,Q9UPT5,P04350,P07437,P36542,Q13505,Q5XKP0,Q9BUR5 16 Pink1 prkn mediated mitophagy 0.7821207382042666 1.8243330840630771 0.0681017316459398 1.0 0.6096871526908272 6 Q9NS69 1 Formation of senescence associated heterochromatin foci sahf 0.7031027553185547 1.8243084556361864 0.0681054528111664 1.0 0.6096871526908272 10 P17096,P16402,P10412 3 Transcriptional regulation by runx1 0.4526816372358381 1.8231850343170215 0.0682753709410357 1.0 0.6096871526908272 71 P60900,Q14781,P28074,P16104,Q99496,P20618,P49721,P62805,P28072,Q16625,P61289 11 Ion channel transport 0.5739669208976188 1.8215790281100488 0.068518885449148 1.0 0.6096871526908272 24 P51798,P21283,Q9UI12,P27105,Q96PU5,Q9C0H2,Q9HD20,P21281,P61421 9 Regulation of runx2 expression and activity 0.4880626492761037 1.8140326845561736 0.0696726939356255 1.0 0.6160300849877781 43 P60900,P28074,Q13309,P20618,P49721,P49720,P28072,P61289 8 Tcf dependent signaling in response to wnt 0.4666598218991154 1.802045183554164 0.0715382970063611 1.0 0.6246187557367909 62 P60900,P28074,P16104,P20618,P49721,P62805,P28072,Q70CQ2 8 Transcriptional regulation by runx3 0.4856832579228427 1.795177750133308 0.072625384264362 1.0 0.6292896974733849 43 P60900,P28074,P20618,P49721,P28072,P61289 6 Tnfr2 non canonical nf kb pathway 0.4884635522865198 1.7759930817638216 0.0757340574415625 1.0 0.6451248673528227 42 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Dectin 1 mediated noncanonical nf kb signaling 0.4859238293363153 1.7561311022393475 0.0790660255333108 1.0 0.6490225686795597 42 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Rac2 gtpase cycle 0.5126422571566185 1.7553930203173278 0.0791921051152926 1.0 0.6490225686795597 36 O15173,Q6IAA8,O75962,Q7L576,Q14739,Q13505,Q9NRY4,P50402,Q14185 9 Endosomal vacuolar pathway 0.8678547186046308 1.7500399961391877 0.0801114124498552 1.0 0.6506723441421379 4 Q9UIQ6 1 Leishmania infection 0.4987068184294037 1.7448320442054164 0.0810141091351612 1.0 0.6519890847592692 39 Q9UQB8,P05067,Q96F07,Q13459,Q7L576,P09601,Q14185 7 G2 m checkpoints 0.4006086642301038 1.726627374545975 0.0842346063563559 1.0 0.6521821942508051 87 P60900,P49721,Q9NWV8,O96028,Q9UQ84,P61289,P28074,P16104,P35250,Q9NXR7,P62805,P28072,P20618,Q99741,Q9UBD5,Q9UL46,P40937,P49720,P38398,Q14997 20 Collagen formation 0.631847063287935 1.726307689774247 0.0842920726746809 1.0 0.6521821942508051 13 O75718,Q32P28,P13674 3 Cdc42 gtpase cycle 0.5082995255068088 1.7242579756574192 0.0846612821527243 1.0 0.6521821942508051 36 Q9UQB8,Q86VI3,P27105,Q6IAA8,O75962,Q13459,Q14739,Q9NRY4,Q07960 9 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.8011916016569942 1.7196900601178615 0.0854887956006171 1.0 0.6521821942508051 5 P01889 1 Cytoprotection by hmox1 0.4525439756468252 1.715453083977768 0.0862621900271709 1.0 0.6521821942508051 65 P60900,P28074,Q13309,Q8TCT9,P20618,P49721,P09669,P28072,P30519,P09601 10 Fcgamma receptor fcgr dependent phagocytosis 0.5171086345634518 1.6908436967998288 0.0908666590154498 1.0 0.6608672252483955 32 Q9UQB8,Q8IV08,Q96F07,Q7L576,Q14185 5 Metalloprotease dubs 0.7217520489507 1.6905457071433334 0.0909236015812753 1.0 0.6608672252483955 7 Q15018,Q9NWV8,Q9NXR7 3 Beta catenin independent wnt signaling 0.4634080248874234 1.6815069830203138 0.0926644812278016 1.0 0.6608672252483955 52 P60900,P28074,P20618,P49721,P28072,P61289 6 Signaling by notch4 0.4763812370132507 1.6812204773264408 0.0927200974578994 1.0 0.6608672252483955 42 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Iron uptake and transport 0.5743381232533463 1.636765288741883 0.1016795211429193 1.0 0.672781117943202 18 Q9UI12,Q658P3,P09601,P30519,P21281,P61421,P63208 7 O linked glycosylation 0.7780718839953393 1.6295840945401014 0.1031894282579695 1.0 0.672781117943202 5 Q10471,O43505 2 Synthesis of pg 0.8354850946723978 1.629115189184405 0.1032886363399607 1.0 0.672781117943202 4 Q8N2A8,Q8IV08 2 Gpcr ligand binding 0.6597015585936785 1.628637429451791 0.103389795751255 1.0 0.672781117943202 10 P05067,Q9NZJ7,P07602,Q9BYT8,P42892 5 Lysosome vesicle biogenesis 0.5971031434192376 1.619065882420443 0.1054330885880125 1.0 0.672781117943202 14 P20645 1 Vitamin c ascorbate metabolism 0.8503469466165396 1.6133333791245386 0.1066720984250806 1.0 0.672781117943202 3 P78417 1 Cyclin a cdk2 associated events at s phase entry 0.4574748970192778 1.6101572525088892 0.1073635309201652 1.0 0.672781117943202 44 P60900,P28074,Q13309,P20618,P49721,P49720,P28072,P61289 8 Class a 1 rhodopsin like receptors 0.6883759341205427 1.602929180139431 0.1089502904753403 1.0 0.672781117943202 8 Q9BYT8,Q9NZJ7,P05067,P42892 4 Peptide ligand binding receptors 0.6883759341205427 1.602929180139431 0.1089502904753403 1.0 0.672781117943202 8 Q9BYT8,Q9NZJ7,P05067,P42892 4 Interleukin 1 signaling 0.4551918587143563 1.599216053223156 0.1097726045588065 1.0 0.672781117943202 49 P60900,P28074,P05067,P20618,P49721,P49720,P28072,P61289 8 Trna modification in the mitochondrion 0.6986228374521563 1.593264428313609 0.1111008830751456 1.0 0.672781117943202 7 O75648,Q9Y2Z2 2 Attachment of gpi anchor to upar 0.8258835475869493 1.5930587313332232 0.1111470161825503 1.0 0.672781117943202 4 Q96S52,Q9H490 2 Parasite infection 0.5292531428353059 1.5838913480412935 0.1132184466085841 1.0 0.6788247635716398 25 Q9UQB8,Q96F07,Q13459,Q7L576,Q14185 5 Stimuli sensing channels 0.6808094592731049 1.5703109542108666 0.1163427869742683 1.0 0.6831395461543605 8 P27105,Q96PU5,Q9C0H2 3 Cdc6 association with the orc origin complex 0.8360134584139416 1.559182150373316 0.1189532743109729 1.0 0.6895341253627766 3 Q9UBD5 1 Metabolism of cofactors 0.7541839493344709 1.535871576915223 0.1245698804057127 1.0 0.7073799423416726 5 P00374 1 Protein localization 0.4263924222905086 1.531826532850991 0.1255652467264316 1.0 0.7073799423416726 69 O43933,Q9NR77,Q9NX63,P05067,P21796,P34913,O15254,O60830,Q9NS69,Q9UJ83,Q99595,Q2T9J0,Q13505,P09601,P50402 15 Degradation of beta catenin by the destruction complex 0.4470003622983711 1.5302401425325247 0.1259572984277006 1.0 0.7073799423416726 49 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Extracellular matrix organization 0.4982784800100864 1.5270401445841193 0.1267510291960896 1.0 0.7073799423416726 30 P05067,Q9Y624,Q32P28,P13674,Q14118,O75718 6 Diseases associated with o glycosylation of proteins 0.9200594353640416 1.524452244512766 0.1273957777071226 1.0 0.7073799423416726 2 O43505 1 S phase 0.3930184793544564 1.5242604460209892 0.1274436636893321 1.0 0.7073799423416726 96 P60900,P49721,Q7Z5K2,Q9NRF9,P61289,P63208,P28074,P30260,Q9BRX5,P35250,Q9UJX6,P35251,P28072,P20618,Q99741,Q9UBD5,Q96DE5,Q9UL46,Q9Y248,Q13309,P31751,P49720,P11802,Q14997 24 Sirt1 negatively regulates rrna expression 0.806044474296006 1.5183228594281937 0.1289330276920486 1.0 0.7073799423416726 4 P16104 1 Cellular response to chemical stress 0.4111538642218849 1.4963386653044433 0.1345654240649159 1.0 0.7073799423416726 75 P60900,P28074,Q13309,Q8TCT9,P20618,P49721,P07237,P09669,P28072,P30519,P61289,P09601 12 Prc2 methylates histones and dna 0.7006543928571923 1.4937602513990935 0.1352382941493604 1.0 0.7073799423416726 6 P16104 1 Class i peroxisomal membrane protein import 0.6730668872445893 1.4849232350861463 0.1375641602717521 1.0 0.7117671551838434 7 O43808,Q9NR77,P56589,P28288 4 Mitotic g2 g2 m phases 0.3826422740553503 1.4559480877527216 0.1454069708045313 1.0 0.7200650203940976 92 P60900,P28074,P20618,P49721,O94927,O75935,Q99996,P28072,P04350,P07437,P61289 11 Plasma lipoprotein remodeling 0.9010401188707284 1.4496704611183149 0.1471504367623057 1.0 0.7200650203940976 2 Q9BU23 1 Antigen presentation folding assembly and peptide loading of class i mhc 0.5560346389247508 1.4349137213029546 0.1513116851613909 1.0 0.7289049109326314 15 P51572,P04439,P01889,Q9NZ08 4 Interleukin 1 family signaling 0.4337826540956322 1.4276761163173577 0.1533851036985345 1.0 0.7338321570782629 52 P60900,P28074,P05067,P20618,P49721,P49720,P28072,P61289 8 Sumoylation of dna methylation proteins 0.7801399823900494 1.420344567542369 0.155507392242941 1.0 0.7364197524182667 4 Q14781 1 Apoptosis induced dna fragmentation 0.5914891358481758 1.4094818198436574 0.1586927454957289 1.0 0.738368302845261 11 P16402,P10412 2 Pten regulation 0.4195936677291291 1.4076569881186345 0.1592326638634682 1.0 0.738368302845261 65 P60900,P28074,Q14781,Q99496,Q9Y2Q5,P20618,P49721,Q6IAA8,P28072,P61289 10 Signaling by vegf 0.4950337839699704 1.402368280153117 0.1608053003577354 1.0 0.738368302845261 26 Q9UQB8,Q96F07,Q7L576 3 Antigen processing ubiquitination proteasome degradation 0.3911831967683295 1.3929347925110946 0.1636395100998582 1.0 0.738368302845261 105 P60900,P49721,Q9UIQ6,O94874,P61289,P63208,P55786,P28074,P30260,Q9UJX6,P28072,Q14139,Q5T4S7,P20618,Q96PU5,Q13309,Q9Y508,Q15386,P49720,Q9Y4B6,Q9UBS8 21 Ptk6 regulates rho gtpases ras gtpase and map kinases 0.7717452848020414 1.3885205755878915 0.1649785838063977 1.0 0.738368302845261 4 Q9NRY4,Q14185 2 Anchoring of the basal body to the plasma membrane 0.4775622034534771 1.386409471892088 0.1656219058159722 1.0 0.738368302845261 30 Q14204,Q15691,P53350,O94927,P68371,O75935,Q99996,P04350,P07437,P30153,P61163,Q13561 12 Cellular response to starvation 0.3728926636974887 1.369374943268843 0.1708821025258748 1.0 0.738368302845261 90 P40429,P62424,Q96EE3,Q6IAA8,P62861,P42766,Q07020,P83881,P47914,Q9NXC5,P39023,P61353,P62269,P61421,Q02878,P61927,P42345,P62081,P62847,P21283,P18124,Q9UI12,Q9Y2Q5,P62277,P62750,P62841,P36578,P21281,P15880,P83731 30 Apoptosis 0.3721828769929595 1.3611763552960143 0.1734579644574894 1.0 0.738368302845261 90 P60900,P28074,P16403,P10412,P20618,P49721,P16402,P28072,Q9UKG1,P61289 10 Regulation of mrna stability by proteins that bind au rich elements 0.4164310242410113 1.3435902157028956 0.1790809351785476 1.0 0.738368302845261 62 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Amino acids regulate mtorc1 0.5371210935547293 1.334707727848889 0.1819720233250259 1.0 0.738368302845261 15 Q9UI12,P21283,Q9Y2Q5,Q6IAA8,Q9NXC5,P21281,P61421 7 O linked glycosylation of mucins 0.7566640145331682 1.3312882773348065 0.1830941739648257 1.0 0.738368302845261 4 O43505,Q10471 2 Cilium assembly 0.4157377360087872 1.3273884773147449 0.1843802093584299 1.0 0.738368302845261 61 Q8NCM8,Q10713,P61163,A6NIH7,A0AVF1,P53350,O94927,O60645,Q9Y496,P68371,O75935,Q99996,P04350,Q9UPT5,P07437,Q8TAG9,Q13561 17 Formation of atp by chemiosmotic coupling 0.6123762635915774 1.321361798517244 0.1863807573015052 1.0 0.738368302845261 9 P36542,O75964,P56385,O75947 4 Mitotic g1 phase and g1 s transition 0.3876773560322385 1.3202297225751274 0.1867583312009924 1.0 0.738368302845261 78 P60900,P28074,Q13309,P20618,P63208,P49721,Q99741,P31350,P49720,P28072,Q9NRF9,P61289,P11802,Q9UBD5,P00374,Q9UL46 16 Signaling by notch 0.4188030726694447 1.3166708174294788 0.1879489896040056 1.0 0.738368302845261 56 P60900,P28074,P16104,P49721,P62805,P28072 6 Fceri mediated nf kb activation 0.421776634423145 1.3145637501330754 0.1886565597115883 1.0 0.738368302845261 45 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.7703442611803819 1.3097751534572746 0.1902719109220463 1.0 0.739414229630765 3 P67812 1 Synthesis secretion and deacylation of ghrelin 0.7703442611803819 1.3097751534572746 0.1902719109220463 1.0 0.739414229630765 3 P67812 1 Post translational modification synthesis of gpi anchored proteins 0.6552893416550328 1.3064926847200542 0.191385065108038 1.0 0.739414229630765 6 Q96S52,Q9H490,Q9ULX3 3 Transport of small molecules 0.4141470364033174 1.2962064758877525 0.1949043590660208 1.0 0.7431309840014596 138 P60900,P49721,Q9C0H2,P61916,Q8WTV0,P11166,P61289,P63208,P28074,Q70HW3,Q9HD20,P28072,P30519,P45880,P28288,P09601,P35610,Q9BU23,P20618,Q9NRK6,Q96PU5,P07237,Q9BUN8,Q8TB61,P30825,P21796,Q9UI12,Q658P3,P27105,P12236,P49720,Q14997,P36404,P21281,O15118 35 Rna polymerase iii transcription initiation from type 1 promoter 0.5345943751218332 1.2952766294931677 0.1952248182738265 1.0 0.7431309840014596 14 Q9Y5Q8,O15160,Q9UKN8,Q8WUA4 4 Response to elevated platelet cytosolic ca2 0.4626931103235818 1.272654572671323 0.2031406442189407 1.0 0.7527519362701862 29 P05067,Q9NUQ9,Q6UXV4,Q9NZJ7,O43852,Q12846,Q8NBX0,P13473 8 Aurka activation by tpx2 0.4579654312853595 1.2658617710932918 0.2055625751530114 1.0 0.7551312296534167 31 Q14204,Q15691,P53350,O94927,P68371,O75935,Q99996,P04350,P07437,P30153,P61163,Q13561 12 Apc c mediated degradation of cell cycle proteins 0.4101331022497214 1.259286650921495 0.2079268131105662 1.0 0.7551312296534167 59 P60900,P28074,Q13309,P20618,P49721,Q9UJX6,P49720,Q96DE5,P28072,P61289,P63208 11 Recognition and association of dna glycosylase with site containing an affected purine 0.7371279504765826 1.257093810356418 0.2087196682096626 1.0 0.7551312296534167 4 P16104 1 Wnt5a dependent internalization of fzd4 0.607323608216738 1.2499869818495588 0.211304302878946 1.0 0.7551312296534167 8 Q00610,P53680,O94973,P63010,P09497,P09496,O95782 7 Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.607323608216738 1.2499869818495588 0.211304302878946 1.0 0.7551312296534167 8 Q00610,P53680,O94973,P63010,P09497,P09496,O95782 7 Sphingolipid metabolism 0.475938836156794 1.2486141831966813 0.2118062222373105 1.0 0.7551312296534167 25 P04062,O95470,Q06136,Q96G23,P10619 5 Downstream signaling events of b cell receptor bcr 0.4135613134217692 1.245895070840363 0.2128029199555554 1.0 0.7551312296534167 45 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 0.680844735276633 1.245464605647718 0.2129610180970966 1.0 0.7551312296534167 5 P24386,Q92696,Q92597,P04637 4 Class i mhc mediated antigen processing presentation 0.3996692944195213 1.242926040605994 0.2138950887208146 1.0 0.7551312296534167 127 P60900,P49721,Q9UIQ6,O94874,P51572,P61289,P63208,P55786,P28074,P30260,Q9UJX6,Q9NZ08,P28072,P04439,Q14139,Q5T4S7,P20618,Q96PU5,Q13309,Q9Y508,Q15386,P49720,Q9Y4B6,O95487,Q12846,Q9UBS8,P01889 27 Regulation of expression of slits and robos 0.3954538280177352 1.2373358018416971 0.2159624416192855 1.0 0.7551312296534167 123 P60900,P40429,P62424,P49721,P62861,Q14118,Q15287,P42766,Q07020,P61289,P28074,P47914,P28070,P28072,P39023,P61353,P62269,Q02878,P61927,P20618,P62081,P62847,Q9UL46,P18124,P49720,A7E2V4,Q9HAU5,P62277,P62750,P62841,P36578,Q14997,P15880,P83731 34 Translation of replicase and assembly of the replication transcription complex 0.7507417733110274 1.2352011921364856 0.2167556357129707 1.0 0.7551312296534167 3 Q99570 1 Rna polymerase iii transcription 0.518094718240242 1.233446466048475 0.2174092380410701 1.0 0.7555241431427239 15 Q9Y5Q8,O15160,Q9UKN8,Q8WUA4 4 Signaling by the b cell receptor bcr 0.4110162988629023 1.223687139762026 0.2210702728576432 1.0 0.7585444307183661 46 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Purinergic signaling in leishmaniasis infection 0.6731895564560445 1.2150410496227877 0.2243504354033767 1.0 0.7585444307183661 5 P09601 1 The nlrp3 inflammasome 0.6731895564560445 1.2150410496227877 0.2243504354033767 1.0 0.7585444307183661 5 P09601 1 Inflammasomes 0.6731895564560445 1.2150410496227877 0.2243504354033767 1.0 0.7585444307183661 5 P09601 1 Assembly of the orc complex at the origin of replication 0.6079494243790878 1.2059897250081375 0.2278214522751525 1.0 0.7632291818426572 7 P62805,Q9UBD5,P16104 3 Vldlr internalisation and degradation 0.6071428571428584 1.2025204583088127 0.229161944603947 1.0 0.7640554573071932 7 Q00610,P53680,O94973,P63010,P09496,O95782 6 Transferrin endocytosis and recycling 0.5473727002933932 1.1966108132882267 0.2314582837844088 1.0 0.7662350257723127 11 P61421,P21281,Q9UI12,Q658P3 4 Mitochondrial biogenesis 0.4434692562014061 1.1946166807624066 0.232236828955703 1.0 0.7662350257723127 33 O75964,Q9NX63,O00411,P36542,Q13505,Q5XKP0,Q9BUR5 7 Signaling by wnt 0.3615691402020725 1.1882245836152645 0.2347449407746591 1.0 0.7680062816444936 84 P60900,P28074,P16104,P20618,P49721,P49720,P62805,P28072,Q70CQ2,P61289,P63208 11 Abc transporters in lipid homeostasis 0.832689450222883 1.181773476864041 0.2372955945349026 1.0 0.7709347571285093 2 P28288 1 Disorders of transmembrane transporters 0.3852551803976297 1.177180608640683 0.2391234267050035 1.0 0.7712622217056408 72 P60900,P28074,P49721,Q9BUN8,P28072 5 Eph ephrin mediated repulsion of cells 0.5594396728950297 1.1656679847992817 0.2437487090662129 1.0 0.7756650263451013 10 Q00610,P53680,O94973,P63010,Q92542,P09497,P09496,O95782 8 Metabolism of folate and pterines 0.5753685875373105 1.1554259283435908 0.2479160491781089 1.0 0.7818029812682127 9 P00374 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.615010683640451 1.1394071969730053 0.2545333555578304 1.0 0.7901846615873092 6 P61009,Q99626,P67812 3 Incretin synthesis secretion and inactivation 0.615010683640451 1.1394071969730053 0.2545333555578304 1.0 0.7901846615873092 6 P61009,Q99626,P67812 3 Neurotransmitter release cycle 0.5897438453173207 1.127680616331292 0.2594548267099119 1.0 0.7908981168914959 7 P80404 1 Amino acid transport across the plasma membrane 0.7223543400713361 1.1274599983546751 0.259548044057944 1.0 0.7908981168914959 3 P30825,Q15758 2 Synthesis of pc 0.6504738266703978 1.1248226331814075 0.2606642015455158 1.0 0.7908981168914959 5 P35790 1 Transcriptional regulation by runx2 0.3981610510494613 1.1247063979408567 0.2607134696603153 1.0 0.7908981168914959 54 P60900,P28074,Q13309,P20618,P49721,P49720,P28072,P11802,P61289,P63208 10 Mismatch repair 0.5097783648234804 1.1107607738922882 0.2666713350088858 1.0 0.7966657823471132 13 Q9UQ84 1 Synthesis of pips at the late endosome membrane 0.7173008323424446 1.1083373894429616 0.2677161336903098 1.0 0.7966657823471132 3 Q99570,Q13614 2 Nef mediated cd4 down regulation 0.6069622136268912 1.1060339441304858 0.2687118275991955 1.0 0.7966657823471132 6 Q9UI12,P53680,O94973,P63010,O95782 5 Nef mediated cd8 down regulation 0.6069622136268912 1.1060339441304858 0.2687118275991955 1.0 0.7966657823471132 6 Q9UI12,P53680,O94973,P63010,O95782 5 Recruitment of mitotic centrosome proteins and complexes 0.4328805657138623 1.1047875022302145 0.2692516771655091 1.0 0.7966657823471132 32 Q14204,Q9Y5B8,Q15691,P53350,O94927,P68371,O75935,Q99996,P04350,P07437,P30153,P61163,Q13561 13 Cargo trafficking to the periciliary membrane 0.4707401307112302 1.1026024273181614 0.2701998556836034 1.0 0.7966657823471132 20 A6NIH7 1 Phosphorylation of the apc c 0.5180296723248436 1.101624283405508 0.2706250467096704 1.0 0.7966657823471132 12 Q9UJX2,P30260,P53350,Q9UJX6,Q96DE5 5 Dna methylation 0.6927281072451605 1.088770513032446 0.276255097888141 1.0 0.798082537272935 4 P16104 1 Transcriptional regulation of pluripotent stem cells 0.7104637336504088 1.0825038766374195 0.2790286937704245 1.0 0.798082537272935 3 Q13485,Q99626 2 Egr2 and sox10 mediated initiation of schwann cell myelination 0.5783275451552702 1.078611466915275 0.2807609673331797 1.0 0.798082537272935 7 Q9NR77,Q16850 2 Intra golgi traffic 0.4845102036281762 1.0781100730531752 0.2809846368560349 1.0 0.798082537272935 16 O43752,O95721,Q16706,O60476,O00461,Q13190 6 Ra biosynthesis pathway 0.8053491827637449 1.0757991212490872 0.2820171053765987 1.0 0.798082537272935 2 Q8NBN7 1 Nonsense mediated decay nmd 0.3436902799924344 1.0702326746256383 0.2845145902764345 1.0 0.798082537272935 87 P40429,P62424,P62861,Q15287,P42766,Q07020,P83881,P47914,Q86US8,P39023,P61353,P62269,Q96Q15,Q02878,P61927,P62081,P62847,P30153,P18124,Q9HAU5,P62277,P62750,P62841,P36578,P15880,P83731 26 Resolution of d loop structures 0.5544510203892894 1.061552323004638 0.2884389676291095 1.0 0.798082537272935 9 Q9UQ84,P38398,O43542 3 Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.5544510203892894 1.061552323004638 0.2884389676291095 1.0 0.798082537272935 9 Q9UQ84,P38398,O43542 3 Retrograde neurotrophin signalling 0.5524140069490868 1.0524197416536258 0.2926070151507853 1.0 0.798082537272935 9 Q00610,P53680,O94973,P63010,P09496,Q9UQ16,O95782 7 Bmal1 clock npas2 activates circadian gene expression 0.7016949339968113 1.0494460353922792 0.2939728799656631 1.0 0.798082537272935 3 P43490 1 Transport of bile salts and organic acids metal ions and amine compounds 0.7003567181926231 1.0444092557353528 0.2962960831638401 1.0 0.798082537272935 3 P53985,P35613 2 Activation of smo 0.7970282317979203 1.0437845626435809 0.2965850754357322 1.0 0.798082537272935 2 Q9Y496 1 Clec7a dectin 1 signaling 0.3895268909198049 1.0407749140403633 0.2979800253101259 1.0 0.798082537272935 49 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Integrin cell surface interactions 0.6776558930526919 1.0319309195335395 0.3021044801309915 1.0 0.8038856357009432 4 Q9Y624,Q9BX67 2 Neddylation 0.3631534400856105 1.0223522181877434 0.3066142267971088 1.0 0.8126495437451517 76 P60900,P28074,Q13309,Q9NX08,P20618,P49721,P49720,P28072,P61289 9 Synthesis of very long chain fatty acyl coas 0.5651802229038937 1.0221980448610346 0.3066871759667813 1.0 0.8126495437451517 7 Q4G176,Q9NZ01,Q53GQ0 3 Transport of vitamins nucleosides and related molecules 0.563312681575038 1.0141966371905846 0.3104889329264741 1.0 0.8126495437451517 7 P12236,Q8TB61 2 Rhod gtpase cycle 0.4223536726101513 1.0082130242963694 0.3133522066378871 1.0 0.8182299676133239 30 O15173,Q658P3,Q9P2R3,O60879,Q14739,Q9NRY4,P50402,Q07960 8 Programmed cell death 0.353412890425109 1.0068006544757275 0.3140305800755338 1.0 0.8184714932192553 101 P60900,P28074,P16403,P10412,P20618,P49721,P16402,O00560,P28072 9 Interleukin 12 signaling 0.4275716580915003 0.995275627823644 0.3196022280717825 1.0 0.8245597136200953 27 O14979,P07237,P14174,Q13126,P78417,Q9UL46 6 Rhog gtpase cycle 0.4031832323110739 0.9930866643634328 0.3206677222358443 1.0 0.8245597136200953 38 Q14185,O15173,O95202,Q6IAA8,O75962,O15498,Q7L576,Q14739,Q9NRY4,P50402,Q13190,Q07960 12 Slc mediated transmembrane transport 0.4543110653504046 0.9922237437965 0.321088392418992 1.0 0.8245597136200953 19 P30825,P12236,Q70HW3,P11166,Q8TB61 5 Tcr signaling 0.3834333043692172 0.9889445528310846 0.3226902707484311 1.0 0.8256379271713522 50 P60900,P28074,P20618,P49721,P49720,P28072,P61289 7 Pkmts methylate histone lysines 0.4473857662005673 0.9818907904049412 0.3261536533620777 1.0 0.8329737728461107 21 O96028,P62805,Q8WTS6,Q9H7B4 4 Basigin interactions 0.5742861209206528 0.971008665691266 0.331543963326159 1.0 0.8352380794355804 6 P08195,P54709,P53985,P35613 4 Metabolism of steroid hormones 0.5738917544688196 0.9693861403861228 0.3323525648043808 1.0 0.8352380794355804 6 P30536 1 Meiotic synapsis 0.4680407396522377 0.96654906513783 0.3337695077073426 1.0 0.8352380794355804 15 P62805,P16104,Q9UH99 3 Diseases of dna repair 0.4706000400799688 0.960138634019859 0.3369854466435238 1.0 0.8352380794355804 14 P54278,Q9UQ84,P38398 3 Cholesterol biosynthesis 0.4528836815676801 0.955489125128548 0.3393304022211061 1.0 0.8352380794355804 18 Q15125,Q16850,Q9UBM7,Q14739 4 Oxidative stress induced senescence 0.4574432107240747 0.9549203949174586 0.3396179550958156 1.0 0.8352380794355804 17 Q14781,Q99496,P16104,P62805,P46734 5 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.4950233131602756 0.9434742860310904 0.3454383618491312 1.0 0.8352380794355804 11 Q13309,Q96DE5,Q9UJX6 3 Rora activates gene expression 0.6721165279429185 0.9387554722893496 0.3478563053250068 1.0 0.8352380794355804 3 Q86X55,P50416 2 Synthesis of pe 0.6706459646417056 0.933292916985584 0.3506687512242352 1.0 0.8352380794355804 3 P35790 1 Diseases of mitotic cell cycle 0.4613405590262216 0.9309818100764796 0.351862973522536 1.0 0.8352380794355804 15 P30260,Q13309,Q96DE5,Q9UJX6 4 Signaling by bmp 0.7649331352154539 0.9217158548409906 0.3566768082928462 1.0 0.8352380794355804 2 Q7Z3T8 1 Ros and rns production in phagocytes 0.5322587228129321 0.9209858069459264 0.357057837148496 1.0 0.8352380794355804 8 P61421,P21281,Q9UI12 3 Transport of inorganic cations anions and amino acids oligopeptides 0.5275076920772326 0.9003458594688513 0.3679362231337291 1.0 0.8352380794355804 8 Q70HW3 1 Insulin receptor recycling 0.5152436396180146 0.886548778118012 0.3753218815275094 1.0 0.8352380794355804 9 P61421,P21281,Q9UI12 3 Ecm proteoglycans 0.6385037581669946 0.885762839326752 0.3757453383262557 1.0 0.8352380794355804 4 P05067 1 Deposition of new cenpa containing nucleosomes at the centromere 0.5329807885826744 0.8849059323326477 0.3762073681955378 1.0 0.8352380794355804 7 P16104 1 Regulation of plk1 activity at g2 m transition 0.3957191933936524 0.8832042846294857 0.3771259070458967 1.0 0.8352380794355804 35 Q14204,Q15691,P53350,O94927,Q13561,P68371,O75935,Q99996,P04350,P07437,P30153,P61163,P63208 13 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4144345956919184 0.88280342733545 0.377342488396404 1.0 0.8352380794355804 26 Q13126 1 Cargo concentration in the er 0.4647794513646645 0.8820751928690036 0.3777361462499833 1.0 0.8352380794355804 13 P53634,Q13190,Q12907 3 G1 s specific transcription 0.4969240600303643 0.8754859339096818 0.3813095604201599 1.0 0.8415315259193735 10 Q99741,P00374 2 C type lectin receptors clrs 0.370009460730308 0.8743485730257814 0.3819284546453794 1.0 0.8415679040056704 51 P60900,P49721,P28074,P28072 4 Cd28 dependent pi3k akt signaling 0.7512630014858848 0.8705704935199855 0.3839887132270236 1.0 0.8417287626604002 2 P31751 1 Diseases of mismatch repair mmr 0.5853084572220204 0.8685324793358647 0.3851028997980639 1.0 0.8417287626604002 5 P54278 1 Rhoa gtpase cycle 0.3687736918836312 0.8642332635790428 0.3874597626607112 1.0 0.8418060473359466 49 Q92974,Q86VI3,O15173,O75955,P27105,O75962,O15498,Q13459,Q9NRY4,Q14254,P30519,Q14739,P28288,P51572,Q13190,Q07960 16 Rhoj gtpase cycle 0.422399955730974 0.849962319020563 0.3953460360664333 1.0 0.846945622319454 22 Q86VI3,P27105,Q6IAA8,O75962,Q07960,O75323,Q9NRY4 7 Cell surface interactions at the vascular wall 0.4578441204747046 0.847152148030462 0.3969103216099174 1.0 0.8478344331636922 13 P54709,P35613,P08195,Q9Y624,Q9BX67,P14174,Q92896 7 Intraflagellar transport 0.4448261625721161 0.8263752927696665 0.4085912344895903 1.0 0.8506396830081618 14 Q8NCM8,A0AVF1,Q9Y496,P04350,P68371 5 Srp dependent cotranslational protein targeting to membrane 0.3247240943173258 0.8261807109812345 0.4087015885093508 1.0 0.8506396830081618 89 P61009,P40429,P62424,P62861,P42766,Q07020,P83881,P47914,P39023,P61353,P62269,Q02878,P61927,P62081,Q15629,P04844,P62847,P43307,P18124,P62277,P62750,P62841,P36578,P15880,P67812,P83731 26 B wich complex positively regulates rrna expression 0.4222159627068016 0.8202454633796651 0.4120761892790741 1.0 0.8506396830081618 20 P62805,P16104 2 Cargo recognition for clathrin mediated endocytosis 0.3953673549270935 0.8172798511628788 0.4137685185967408 1.0 0.8506396830081618 29 P20645 1 Ptk6 regulates proteins involved in rna processing 0.6377425392996261 0.8124289566582739 0.416545536318718 1.0 0.8506396830081618 3 O75525 1 Inhibition of dna recombination at telomere 0.4576469894704506 0.8037900373290117 0.4215182444445329 1.0 0.8509058075986743 12 P16104 1 Fatty acid metabolism 0.3614594918122146 0.8024568878341188 0.422288717309025 1.0 0.8509058075986743 53 Q15165,O43772,O15254,P49748,Q53GQ0,P50897,Q9UJ83,P23786,P34913 9 Mapk family signaling cascades 0.3245996054665531 0.7993141272885562 0.4241082892387959 1.0 0.8509058075986743 85 P60900,P28074,Q99956,Q92796,Q9Y2Q5,P20618,P49721,Q96S59,P49720,P28072,O60725,P36404,P61289 13 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.4562802318931535 0.7971446825537835 0.4253670084903354 1.0 0.8509058075986743 12 P09601,P05067,P50402 3 Fc epsilon receptor fceri signaling 0.3604784836640906 0.795334761589436 0.4264187979155296 1.0 0.8509058075986743 54 P60900,P49721,P28074,P28072 4 Peptide hormone metabolism 0.4350656564053525 0.7925903949407321 0.4280165066513581 1.0 0.8517650424386715 15 P61009,Q99626,O60645,Q9UPT5,P67812,Q8TAG9 6 Metabolism of steroids 0.3587556613914708 0.7812740611811095 0.4346413226488201 1.0 0.8577249921575847 48 Q15800,P04062,Q15125,Q16850,Q53GQ0,P30536,Q9UBM7,Q14739 8 Piwi interacting rna pirna biogenesis 0.4601171155043032 0.7769000480145043 0.4372177429289978 1.0 0.8590621474990295 11 Q9Y2W6,Q8N2A8,P30876 3 Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 0.6051833918692899 0.7640425689181493 0.4448418751008181 1.0 0.8659309738303158 4 P16104 1 Recruitment of numa to mitotic centrosomes 0.3745111848437359 0.7448266908218794 0.4563764972585327 1.0 0.8679654778443935 36 Q14204,Q9Y5B8,Q15691,P53350,O94927,P68371,O75935,Q99996,P04350,P07437,P30153,P61163,Q13561 13 Rna polymerase iii chain elongation 0.4910865910968162 0.7439851360941442 0.4568854675251983 1.0 0.8679654778443935 8 O15160,O14802 2 Rna polymerase iii transcription initiation from type 3 promoter 0.4910865910968162 0.7439851360941442 0.4568854675251983 1.0 0.8679654778443935 8 O15160,O14802 2 Activation of anterior hox genes in hindbrain development during early embryogenesis 0.4158748078387454 0.728228529029603 0.4664737046434015 1.0 0.8679654778443935 17 P16104,Q92600,P30876,P62805,Q9UBL3 5 Energy dependent regulation of mtor by lkb1 ampk 0.48689868037752 0.7262825728047 0.4676655606284772 1.0 0.8679654778443935 8 Q9Y376,Q6IAA8 2 Proton coupled monocarboxylate transport 0.7111441307578017 0.7244260318702923 0.468804222972446 1.0 0.8679654778443935 2 P35613 1 Interleukin 23 signaling 0.7102526002971778 0.7212579668860222 0.4707508130352318 1.0 0.8679654778443935 2 P07237 1 Translocation of slc2a4 glut4 to the plasma membrane 0.3635752894382446 0.7138374564579703 0.4753276952203644 1.0 0.8679654778443935 39 Q12846,Q9UIQ6,Q9UPT5,Q9Y496 4 Ras processing 0.5905641162325614 0.7117559046417178 0.4766159426148415 1.0 0.8679654778443935 4 O60725 1 Synthesis of pips at the er membrane 0.6066876355205959 0.7014796098378879 0.4830037551547312 1.0 0.8684121569512993 3 P42356 1 Interleukin 12 family signaling 0.3766898670027972 0.6989963042252334 0.4845543404959418 1.0 0.8692685811811609 30 P78417,Q13126 2 Intracellular signaling by second messengers 0.3142946297176351 0.6956800995178527 0.4866291909830067 1.0 0.8715653587221288 90 P60900,Q14781,P28074,Q99496,Q9Y2Q5,P20618,P49721,Q6IAA8,P28072,P61289 10 Metabolism of lipids 0.396740276755516 0.6852972407796075 0.4931563725914265 1.0 0.8782096326147426 187 Q15165,O43772,Q8NCC3,Q71SY5,Q53GQ0,Q06136,P50897,Q96G23,Q14739,O95822,O95470,Q8IV08,Q9NPH0,Q9UG56,Q9NZJ7,Q92604,Q8N9F7,Q9UBM7,P34913,P10619,Q9H4L5,Q15800,O15254,Q15125,Q16850,P23786,P35790,P04062,Q8N2A8,P49748,Q9UJ83,P30536,P42356 33 Negative regulation of nmda receptor mediated neuronal transmission 0.5356620137028381 0.6797355832168347 0.496671900914341 1.0 0.8792169175676309 5 Q14012,Q92796 2 N glycan trimming in the er and calnexin calreticulin cycle 0.4219622748273512 0.669351704979862 0.5032711513276715 1.0 0.8815076575915726 13 Q9BUN8,Q9NYU2 2 Response of eif2ak4 gcn2 to amino acid deficiency 0.3291891836306664 0.6612380772052856 0.5084596457428969 1.0 0.8815076575915726 75 P40429,P62424,P62861,P42766,Q07020,P47914,P39023,P61353,P62269,Q02878,P61927,P62081,P62847,P18124,P62277,P62750,P62841,P36578,P15880,P83731 20 Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.4332999289962925 0.6519289077635188 0.514447035364378 1.0 0.8815076575915726 11 Q9UI12,P53680,O94973,P63010,O43747,P04439 6 Regulation of tp53 activity through association with co factors 0.6900445765230321 0.6505562195024773 0.515332999520808 1.0 0.8815076575915726 2 P31751 1 Runx3 regulates cdkn1a transcription 0.6900445765230323 0.650556219502477 0.5153329995208082 1.0 0.8815076575915726 2 Q13485 1 Tp53 regulates transcription of caspase activators and caspases 0.6900445765230323 0.650556219502477 0.5153329995208082 1.0 0.8815076575915726 2 P42575 1 Diseases of programmed cell death 0.3760816715109187 0.6408805198907 0.5216003131473581 1.0 0.8864667122467874 26 P62805,Q08379,P16104 3 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.5863168481031967 0.630919757729351 0.5280929924601312 1.0 0.8901498988211515 3 P30153 1 Pp2a mediated dephosphorylation of key metabolic factors 0.5863168481031967 0.630919757729351 0.5280929924601312 1.0 0.8901498988211515 3 P30153 1 Signaling by ptk6 0.4128448096841162 0.6252452778969466 0.5318100891730406 1.0 0.8901498988211515 13 Q96JJ3,O75525,P40763,P11802,P18031,Q9NRY4,Q14185 7 Fatty acyl coa biosynthesis 0.4049329492667478 0.6244420163081983 0.5323373388805026 1.0 0.8901498988211515 14 P50897,Q53GQ0 2 Lrr flii interacting protein 1 lrrfip1 activates type i ifn production 0.6728083209509669 0.5921130993835628 0.553774855689225 1.0 0.9019420653567872 2 P35222 1 Rna polymerase iii transcription termination 0.4448282400680159 0.5827860730335879 0.560037321519884 1.0 0.9055233080593494 9 O15160,O14802 2 Golgi cisternae pericentriolar stack reorganization 0.4442503108039947 0.580393329246211 0.5616494025907357 1.0 0.9070800178257314 9 Q08379,Q9H8Y8 2 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.4304674273855327 0.5779979058973002 0.5632655330484873 1.0 0.9081803554510488 10 Q96DE5,Q9UJX6 2 Disassembly of the destruction complex and recruitment of axin to the membrane 0.4570574771348817 0.5732271451830339 0.5664909069904303 1.0 0.9085967819352824 7 P30153,Q14738,P35222,P48729 4 Signaling by ctnnb1 phospho site mutants 0.4570574771348817 0.5732271451830339 0.5664909069904303 1.0 0.9085967819352824 7 P30153,Q14738,P35222,P48729 4 Beta catenin phosphorylation cascade 0.4570574771348817 0.5732271451830339 0.5664909069904303 1.0 0.9085967819352824 7 P30153,Q14738,P35222,P48729 4 Downregulation of erbb4 signaling 0.6627043090638941 0.5587520911869297 0.5763309230543274 1.0 0.918055073554043 2 P46934 1 Activated notch1 transmits signal to the nucleus 0.6627043090638942 0.5587520911869294 0.5763309230543276 1.0 0.918055073554043 2 Q92542 1 Synaptic adhesion like molecules 0.4699963614514255 0.5574113979305009 0.5772463797792757 1.0 0.918466050742196 6 Q14254,Q92796 2 Signaling by robo receptors 0.348222596879176 0.5546139176229751 0.5791587673647369 1.0 0.9191387449777694 138 P60900,P40429,O43639,P62424,P49721,P62861,Q14118,Q15287,P42766,Q07020,P61289,P28074,P47914,P28070,P28072,P39023,P61353,P62269,Q02878,P61927,P20618,P62081,P62847,Q13459,Q9UL46,P18124,P49720,A7E2V4,Q9HAU5,P62277,P62750,P62841,P36578,Q14997,P15880,P83731 36 Scavenging by class a receptors 0.5630202140309054 0.5529452349876908 0.5803009112887563 1.0 0.9191387449777694 3 P14625,P27797 2 Intra golgi and retrograde golgi to er traffic 0.3072268185551497 0.5465684469258849 0.5846752515238607 1.0 0.9215749962238552 96 Q9BVK6,Q16706,O60476,P20645,Q9UJW0,O15260,Q9UID3,Q13190,O43752,Q9Y496,O75935,P04350,Q15102,P61163,Q13561,P61923,Q6NUQ1,O00461,Q9P2W9,Q10471,O95721,O15498,A2RRP1,Q10472,P68371 25 Signaling by insulin receptor 0.3856840057595347 0.5416191857821159 0.5880808721427684 1.0 0.925167768449828 15 P31751,Q9UI12,Q99570,P21281,P61421 5 Eukaryotic translation elongation 0.3143781115754238 0.5295095123377739 0.5964520474627188 1.0 0.9297847552066624 76 P40429,P62424,P62861,P42766,Q07020,P47914,P39023,P61353,P62269,Q02878,P61927,P62081,P62847,P18124,P62277,P62750,P62841,P36578,P15880,P83731 20 The role of nef in hiv 1 replication and disease pathogenesis 0.391433799526718 0.5241021424019285 0.6002074985331469 1.0 0.9297847552066624 13 Q9UI12,P53680,O94973,P63010,O43747,P04439 6 Dna double strand break response 0.3593319631250391 0.522844476293033 0.6010824858878712 1.0 0.9297847552066624 25 Q99496,P16104,Q9NWV8,Q9NXR7,O96028,P62805,O00213,O95677 8 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.4918509824508782 0.5223380620979264 0.6014349725290313 1.0 0.9297847552066624 5 P12236 1 Dcc mediated attractive signaling 0.4909259007121207 0.5191426694218825 0.6036612548120563 1.0 0.9297847552066624 5 Q14185 1 Rnd3 gtpase cycle 0.3695327570540794 0.5021182222549984 0.6155843629018414 1.0 0.934022964366384 18 O43396,Q9Y2I1,Q9NYL9,Q14254,O75976,Q9NRY4 6 Cellular senescence 0.3231890411187949 0.4990288191176327 0.6177590816333636 1.0 0.934656491702038 46 Q14781,P16104,P16403,P10412,P16402,Q9UJX6,P46734,P17096,P62805,Q96DE5 10 Synthesis of pips at the golgi membrane 0.4377192152284218 0.4987769809374682 0.6179365058080157 1.0 0.934656491702038 7 Q99570,Q10713,P42356 3 Syndecan interactions 0.5272135911053346 0.496920631095075 0.6192450221497319 1.0 0.9352273469655952 4 Q9Y296 1 Formation of the beta catenin tcf transactivating complex 0.3969335763016417 0.4896520260988781 0.6243801547650756 1.0 0.9375908820986256 11 P62805,P16104 2 Interleukin 4 and interleukin 13 signaling 0.3905749897685964 0.4896338535640128 0.6243930163495923 1.0 0.9375908820986256 12 P09601 1 Apc c cdc20 mediated degradation of cyclin b 0.3885070242336801 0.4804938223000849 0.6308762948776196 1.0 0.9375908820986256 12 Q96DE5,Q9UJX6 2 Rna polymerase i promoter escape 0.3700399060345233 0.4771264532561165 0.6332720786945556 1.0 0.9375908820986256 16 P62805,P16104 2 Host interactions of hiv factors 0.3007347280817599 0.476803390693355 0.6335021310402089 1.0 0.9375908820986256 96 P60900,P28074,Q9UI12,P20618,P12236,P49721,P49720,P17096,P28072,P61289,P04439,P63208 12 Trans golgi network vesicle budding 0.3388446717268912 0.4763079961994604 0.633854969516336 1.0 0.9375908820986256 34 Q12846,P05067,P20645 3 Pre notch expression and processing 0.4247778165176658 0.474848332715645 0.6348950802706541 1.0 0.9375908820986256 8 P16104 1 Transcriptional regulation of granulopoiesis 0.4245671430687165 0.4740421629875951 0.6354698409709711 1.0 0.9375908820986256 8 P62805,P16104 2 Peroxisomal lipid metabolism 0.3870392626417521 0.4740331969442876 0.6354762345695149 1.0 0.9375908820986256 12 Q9UJ83,O15254 2 Base excision repair ap site formation 0.4402962718985154 0.4500120176076286 0.6527017752561222 1.0 0.9495780117650616 6 P16104 1 Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 0.3182169716638264 0.447845888595451 0.6542644229121157 1.0 0.9501116411727916 50 Q9Y262,P62861,P62847,P62277,P62841,P62269 6 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.3662228843977062 0.4397297910527816 0.6601328231237464 1.0 0.9539292308593016 14 P09601 1 Platelet activation signaling and aggregation 0.3163241300076019 0.4387842904393944 0.6608178443193107 1.0 0.9539292308593016 48 P05067,Q9NUQ9,Q6UXV4,Q9NZJ7,O43852,Q12846,P04899,Q8NBX0,P13473,Q8N2K0 10 Noncanonical activation of notch3 0.6154531946508186 0.4132133941570368 0.6794502756278165 1.0 0.9633384942753636 2 Q92542 1 Rhoq gtpase cycle 0.3467323341598885 0.4119576348974478 0.6803704754512019 1.0 0.9633384942753636 21 Q86VI3,P27105,Q6IAA8,Q07960,Q9NRY4 5 Eukaryotic translation initiation 0.2986483180695686 0.4111259617176058 0.680980174119366 1.0 0.9633384942753636 100 P40429,P62424,P62861,P42766,O75822,Q07020,P62888,P62701,P83881,P62244,P56537,P46781,P62851,P62241,P47914,P61353,P39023,P60228,P62269,O15372,Q9UBQ5,P84098,Q02878,P61927,P62081,Q14152,P61513,P62847,Q14232,Q9Y3U8,P32969,P18124,Q9Y262,P62277,P62750,P49770,P62841,P18077,P36578,P15880,P83731,P55010 42 Non integrin membrane ecm interactions 0.4284202914409971 0.4091481867421752 0.6824309155612924 1.0 0.9633384942753636 6 Q9Y296,Q14118 2 Tp53 regulates transcription of death receptors and ligands 0.6124814264487382 0.4047117111408379 0.6856894327738621 1.0 0.9633384942753636 2 P04637 1 Signaling by interleukins 0.3087781462119531 0.4014196918787516 0.6881111537225912 1.0 0.9633384942753636 111 P60900,P28074,P05067,P20618,P49721,P49720,P07237,P46734,Q12846,P28072,Q13126,P78417,P61289,P09601 14 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.6095096582466579 0.3962948910360405 0.6918874957443115 1.0 0.9633384942753636 2 P04637 1 Apoptotic execution phase 0.3282788132321605 0.3937379317844099 0.6937745333499388 1.0 0.9633384942753636 31 P16402,Q16625,P16403,P10412 4 Vitamin b5 pantothenate metabolism 0.4936068986024461 0.3937238621534473 0.693784922014647 1.0 0.9633384942753636 4 Q9NRN7,Q9NVE7,P49327 3 Activation of gene expression by srebf srebp 0.3501523840247125 0.3932676878466086 0.6941217809205611 1.0 0.9633384942753636 17 Q9UBM7 1 Post chaperonin tubulin folding pathway 0.3731857943979598 0.3902574670387068 0.6963461711044088 1.0 0.9633384942753636 11 P36404,Q9BTW9,P04350,P68371 4 Condensation of prophase chromosomes 0.3726208613589808 0.3879723653022027 0.698036484242738 1.0 0.9633384942753636 11 P16104 1 Branched chain amino acid catabolism 0.3525990223524312 0.3857804452542536 0.699659278793781 1.0 0.9633384942753636 15 P35610,O15382,Q02252,P45954,Q9HCC0 5 Meiotic recombination 0.3565391070329201 0.3691917017940561 0.7119848406776941 1.0 0.9658310514041826 13 P62805,P38398,P16104,P11802 4 Maturation of sars cov 2 spike protein 0.365916077645247 0.3611653483768931 0.7179758443038695 1.0 0.9658310514041826 11 P46977,P61803,Q16706 3 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.4994054696789414 0.3598320166373201 0.7189727588835864 1.0 0.9658310514041826 3 Q9HCE1,Q9Y4C1 2 Glucuronidation 0.4985136741973718 0.3573760984770034 0.7208102675723902 1.0 0.9658310514041826 3 Q16851,Q9NUJ1 2 Ras activation upon ca2 influx through nmda receptor 0.4791257569919062 0.3522666567388848 0.7246382915636498 1.0 0.9658310514041826 4 Q92796 1 Unblocking of nmda receptors glutamate binding and activation 0.4791257569919062 0.3522666567388848 0.7246382915636498 1.0 0.9658310514041826 4 Q92796 1 Long term potentiation 0.4791257569919062 0.3522666567388848 0.7246382915636498 1.0 0.9658310514041826 4 Q92796 1 Receptor mediated mitophagy 0.4964328180737092 0.3516763422723951 0.7250810047189518 1.0 0.9658310514041826 3 Q96HS1,P19784 2 Rhobtb1 gtpase cycle 0.3318867060377636 0.3371019826807042 0.7360400228554331 1.0 0.9679534356765852 21 O43396 1 Pka activation in glucagon signalling 0.5863298662704322 0.3336944503716921 0.7386101377460557 1.0 0.9679534356765852 2 P10644 1 Creb1 phosphorylation through the activation of adenylate cyclase 0.5863298662704322 0.3336944503716921 0.7386101377460557 1.0 0.9679534356765852 2 P10644 1 Pka mediated phosphorylation of creb 0.5863298662704322 0.3336944503716921 0.7386101377460557 1.0 0.9679534356765852 2 P10644 1 Homology directed repair 0.3015605095831386 0.3282515524200844 0.742721472013423 1.0 0.9698153161553096 48 P16104,Q9NWV8,P40937,O43542,P35250,Q9NXR7,O96028,P35251,P62805,P38398,Q92889,Q9NRF9,Q9UNS1,Q9UQ84 14 Rhobtb2 gtpase cycle 0.3304863627415315 0.3263451569790819 0.7441632263495226 1.0 0.9701414480074688 20 O43396 1 Small interfering rna sirna biogenesis 0.5824665676077281 0.3238104030044654 0.7460815797368532 1.0 0.9713662319593512 2 Q9UPY3 1 Atf6 atf6 alpha activates chaperones 0.5777117384843995 0.3118701497628282 0.7551392088968398 1.0 0.9720442871487536 2 P14625 1 Atf6 atf6 alpha activates chaperone genes 0.5777117384843995 0.3118701497628282 0.7551392088968398 1.0 0.9720442871487536 2 P14625 1 Surfactant metabolism 0.5768202080237754 0.3096592771414184 0.756820073656219 1.0 0.9720442871487536 2 Q9P031 1 Synthesis of pips at the early endosome membrane 0.4231328577605486 0.3049702140230299 0.7603888381020378 1.0 0.9726934971090602 5 Q99570,Q13614 2 Processing of dna double strand break ends 0.3110920300781003 0.298054056498344 0.7656619063113699 1.0 0.9726934971090602 33 P16104,Q9NWV8,P40937,P35250,Q9NXR7,O96028,P62805,P38398,Q9UNS1,Q9UQ84 10 Signaling by retinoic acid 0.3701025383985391 0.2979360263507833 0.7657519908190602 1.0 0.9726934971090602 9 Q8NBN7,P11177,Q8TC12,Q15118,Q15120 5 Maturation of sars cov 1 spike protein 0.4558429973238262 0.2899982576389474 0.771817570559562 1.0 0.9766568352098806 4 P27824,Q13724,Q14697 3 Rmts methylate histone arginines 0.3225359675339433 0.2889463198300431 0.7726224566595246 1.0 0.9767905628537156 20 P62805,P16104,P11802,Q86X55 4 Regulation of cholesterol biosynthesis by srebp srebf 0.3191295810933712 0.2854269589049625 0.775317055954448 1.0 0.9769964101631514 23 Q9UBM7 1 Copi independent golgi to er retrograde traffic 0.3090240777237389 0.2800744371182794 0.7794203963897157 1.0 0.9769964101631514 30 Q10471,P68371,O75935,P04350,Q9UJW0,Q10472,P61163,Q13561 8 Ikk complex recruitment mediated by rip1 0.4452697629596344 0.2636596559255405 0.7920421856396043 1.0 0.9835192167817428 4 Q6SZW1 1 Trafficking of glur2 containing ampa receptors 0.3789933214187342 0.2554684094422806 0.7983613398929825 1.0 0.9835192167817428 6 P53680,O95782,O94973,P63010 4 Metabolism of vitamins and cofactors 0.2915581008375281 0.250211160092752 0.8024240551947195 1.0 0.9842534617386006 50 Q8N0U8,Q4G0N4,Q9H2D1,P43490,P00374,Q5T2R2 6 Vxpx cargo targeting to cilium 0.3552746246185534 0.2492277138710137 0.8031846430794594 1.0 0.9842534617386006 9 Q9UPT5,O60645,Q8TAG9 3 Rho gtpase cycle 0.3403060634342991 0.2369033469131335 0.8127317734316892 1.0 0.9890124455436148 167 Q9UQB8,Q9Y2I1,O43639,Q96JJ3,Q96F07,Q6IAA8,Q9P2R3,Q96KM6,Q9BX68,Q9BT78,P42167,Q16543,Q14739,Q13505,Q9NRY4,P51572,Q13190,Q15208,O95202,Q9NYL9,P12814,Q14254,O75976,P30519,Q7L576,Q658Y4,P28288,Q14185,Q13464,Q92974,Q9BTT6,O15173,Q99707,Q13459,O75323,P50402,O43396,Q9Y512,Q9Y4F1,Q86VI3,O75955,P27105,Q9UEY8,O75962,Q658P3,O15498,Q07021,Q07960,O60879 49 Interferon alpha beta signaling 0.3510235533067787 0.2358694709289649 0.8135339585869095 1.0 0.9891270149224652 9 P01889 1 Beta oxidation of butanoyl coa to acetyl coa 0.447681331747905 0.2314963116293283 0.8169292505216978 1.0 0.992391446068532 3 Q16836,P40939 2 Transcriptional regulation of white adipocyte differentiation 0.3126092314511601 0.2194446830765582 0.8263036660953671 1.0 0.9966700700483616 15 Q9NPJ6,Q71SY5,O60244,O75448,P11802 5 E3 ubiquitin ligases ubiquitinate target proteins 0.3067847862821843 0.2188262761964085 0.8267853774454466 1.0 0.9966700700483616 20 Q9BUN8,Q149N8 2 Activation of rac1 downstream of nmdars 0.4408442330558736 0.2168506139089388 0.8283247661244584 1.0 0.9966700700483616 3 P63000,Q14012 2 Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0.4408442330558716 0.2168506139089348 0.8283247661244615 1.0 0.9966700700483616 3 Q13555,P52292 2 Insulin processing 0.3416294571094825 0.2073670781408392 0.8357231916098786 1.0 0.9966700700483616 9 Q9UPT5,O60645,Q8TAG9 3 Defective intrinsic pathway for apoptosis 0.3077468364183396 0.2045224101889347 0.8379452812968198 1.0 0.9966700700483616 16 Q08379 1 Transcriptional regulation by ventx 0.30725572508355 0.2026648949205194 0.8393969635220719 1.0 0.9966700700483616 16 Q96DE5,Q9UJX6 2 Rnd1 gtpase cycle 0.3080210383379503 0.2023416948150564 0.8396496062893575 1.0 0.9966700700483616 15 O43396 1 Signaling by erbb2 ecd mutants 0.3807257584770881 0.1967859194710627 0.843995070301111 1.0 0.9966700700483616 5 Q16543,P62993,Q96RT1,P19174 4 Signaling by erbb2 in cancer 0.3807257584770881 0.1967859194710627 0.843995070301111 1.0 0.9966700700483616 5 Q16543,P62993,Q96RT1,P19174 4 Negative epigenetic regulation of rrna expression 0.296114103059838 0.1951748683058421 0.8452560528900879 1.0 0.9966700700483616 26 P62805,Q9UHR5,P16104 3 Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0.3040919858778782 0.1908300673877868 0.848658731176565 1.0 0.9966700700483616 16 Q14781 1 Establishment of sister chromatid cohesion 0.3431520302584904 0.1903109192347911 0.8490654977051748 1.0 0.9966700700483616 7 Q7Z5K2,Q8N3U4 2 Reproduction 0.2957162248325639 0.1867905290821543 0.8518248729232121 1.0 0.9966700700483616 25 P62805,Q9UH99,P16104 3 Meiosis 0.2957162248325639 0.1867905290821543 0.8518248729232121 1.0 0.9966700700483616 25 P62805,Q9UH99,P16104 3 Striated muscle contraction 0.374265606882212 0.1824154337112546 0.8552567146554211 1.0 0.9966700700483616 5 P28289 1 Selective autophagy 0.2901505339346344 0.1806645683075033 0.8566308714737447 1.0 0.9966700700483616 30 Q9NS69 1 Fcgr3a mediated il10 synthesis 0.4221165279429169 0.1797203721711387 0.8573720991728879 1.0 0.9966700700483616 3 P13861,P10644 2 Muscle contraction 0.293574331813128 0.168718180012417 0.866018318200884 1.0 0.9966700700483616 23 Q99996 1 Deadenylation of mrna 0.296947412597386 0.1680813977912802 0.8665192435576827 1.0 0.9966700700483616 17 Q9UIV1,Q92600 2 Initiation of nuclear envelope ne reformation 0.2983105640150431 0.1676931048491888 0.8668247209082027 1.0 0.9966700700483616 15 Q14739 1 Hdr through single strand annealing ssa 0.2931055402613033 0.1580925188282562 0.8743838955901597 1.0 1.0 18 P40937,P35250,P38398,Q92889,Q9UQ84 5 Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.3153039846893659 0.155916256334552 0.8760990313179204 1.0 1.0 10 Q9UIV1,Q92600 2 Signaling by erythropoietin 0.4075505350772787 0.153930081508414 0.8776648651526036 1.0 1.0 3 P19174,P46109 2 Signaling by ntrk3 trkc 0.4075505350772782 0.1539300815084134 0.877664865152604 1.0 1.0 3 P19174,Q8WX92 2 Coenzyme a biosynthesis 0.4933135215453211 0.1446116342981978 0.885017510957298 1.0 1.0 2 Q9NVE7 1 Mhc class ii antigen presentation 0.2774135963933908 0.1382181667134831 0.8900679979377393 1.0 1.0 60 Q9Y496,P68371,O75935,O95487,P53634,Q9UQ16,P04350,Q9UJW0,P10619,P61163,Q13561 11 Constitutive signaling by overexpressed erbb2 0.3806125483199596 0.1322847485580913 0.8947590702450601 1.0 1.0 4 Q16543,P62993,Q96RT1 3 Cell extracellular matrix interactions 0.3155701101518264 0.129586016191023 0.8968939674138074 1.0 1.0 8 Q15404,Q13418,Q14315,P05556,P50552,P12814,P21333 7 Cohesin loading onto chromatin 0.3153197733505017 0.129005769523243 0.8973530835609862 1.0 1.0 8 Q7Z5K2,Q8N3U4 2 Ire1alpha activates chaperones 0.2833611589092822 0.1270187397399526 0.8989255665148803 1.0 1.0 23 P43307,O95070,O14773,P49748 4 Rhoc gtpase cycle 0.2779078989678889 0.1232883979959047 0.9018787277997772 1.0 1.0 35 Q86VI3,O75955,P27105,Q13459,Q14254,Q14739,P28288,Q9NRY4,Q13190,Q07960 10 G2 m dna damage checkpoint 0.2744145034993133 0.1203331089714268 0.9042192774936983 1.0 1.0 39 P16104,Q9NWV8,P40937,P35250,Q9NXR7,O96028,P62805,P38398,Q9UQ84 9 Mitotic telophase cytokinesis 0.2935545414623331 0.11822014112482 0.905893231554488 1.0 1.0 11 O95235,P53350,Q7Z5K2,Q8N3U4,O60216 5 Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.340027007097209 0.1163067487745027 0.9074094371656644 1.0 1.0 5 Q99570 1 Camk iv mediated phosphorylation of creb 0.367826345524835 0.1127011129066163 0.910267518900892 1.0 1.0 4 Q13555,Q96RR4,P52292 3 Triglyceride metabolism 0.3657448706512111 0.1097152608549953 0.9126351970726898 1.0 1.0 4 P62140,P43304,O60664 3 Triglyceride catabolism 0.3657448706512111 0.1097152608549953 0.9126351970726898 1.0 1.0 4 P62140,P43304,O60664 3 Nonhomologous end joining nhej 0.2773221113935846 0.1042941072101077 0.9169359541773374 1.0 1.0 20 O96028,P62805,Q9NWV8,P16104 4 Homologous dna pairing and strand exchange 0.2765578745187831 0.1034605633398339 0.9175974473767412 1.0 1.0 19 P40937,O43542,P35250,P38398,Q9UQ84 5 Rhof gtpase cycle 0.2772713505205607 0.1031168202218948 0.9178702555793684 1.0 1.0 21 Q13613,Q9Y4F1,Q658P3,Q9UEY8,Q13459,P42167,P12814,Q5JTV8,Q07960,O60879 10 Pyruvate metabolism 0.277169164829639 0.0999312045936244 0.9203989426574004 1.0 1.0 16 P21796,P35613,P11177,Q8NCN5,Q15118,Q15120 6 Assembly and cell surface presentation of nmda receptors 0.2852725566560891 0.0969377382321061 0.9227758391431848 1.0 1.0 11 P04350,Q92796 2 Rab geranylgeranylation 0.2743971043525013 0.096210714539364 0.9233532213216922 1.0 1.0 19 P24386,P61026,Q9NP72,Q92696,P20339,P51148,Q9ULC3,P53611,Q9BZG1 9 Irs mediated signalling 0.3531951088578277 0.0928985035009309 0.925984194640996 1.0 1.0 4 Q99570 1 Irak1 recruits ikk complex 0.3620689655172351 0.0908472874822606 0.927613935396046 1.0 1.0 3 P51617,O15111 2 Ticam1 rip1 mediated ikk complex recruitment 0.3620689655172351 0.0908472874822603 0.9276139353960462 1.0 1.0 3 Q13546,O15111 2 Alpha oxidation of phytanate 0.3497542728400554 0.0886390132987521 0.9293688019691448 1.0 1.0 4 Q9UJ83 1 Cell cell junction organization 0.2944116148173628 0.0828816359826565 0.9339456561574389 1.0 1.0 7 P19022 1 Activation of the pre replicative complex 0.2691386570221098 0.076832537288853 0.938756766221306 1.0 1.0 20 Q9UBD5,Q99741 2 Circadian clock 0.2810167509451926 0.0721022660710021 0.9425205228576704 1.0 1.0 10 P43490,Q86X55,P63208 3 Dag and ip3 signaling 0.2852039297409883 0.0675745027105881 0.9461243528817496 1.0 1.0 8 P52292,P10644,Q13555,P13861,Q13557,P19174,Q96RR4 7 Ca dependent events 0.2852039297409878 0.0675745027105867 0.9461243528817508 1.0 1.0 8 P52292,P10644,Q13555,P13861,Q13557,Q96RR4,P28482 7 Gene silencing by rna 0.2605534772640996 0.0673780197993804 0.9462807670766932 1.0 1.0 47 P16104,Q8N2A8,O15397 3 Inla mediated entry of listeria monocytogenes into host cells 0.4160475482912351 0.0657648589861424 0.9475650341100316 1.0 1.0 2 P35222 1 Calnexin calreticulin cycle 0.2868193989884054 0.0620965516096583 0.9504859431175544 1.0 1.0 6 Q14697,P14314,P27824,P27797,Q9NYU2 5 Interleukin 15 signaling 0.4074294205052024 0.0606892037203461 0.9516067300155244 1.0 1.0 2 P40763 1 Erythropoietin activates ras 0.4074294205052023 0.0606892037203461 0.9516067300155244 1.0 1.0 2 P46109 1 Hdr through homologous recombination hrr 0.2600015048780761 0.0524618514390868 0.9581606915958684 1.0 1.0 28 P40937,O43542,P35250,P35251,P38398,Q9NRF9,Q9UQ84 7 Nef mediated downregulation of mhc class i complex cell surface expression 0.2872623086008476 0.0477279047954495 0.9619330946288368 1.0 1.0 5 P04439,O43747 2 Signaling by flt3 fusion proteins 0.3071662206363448 0.0476764070965086 0.9619741371251485 1.0 1.0 4 Q01082,P62993,Q14789 3 Regulation of innate immune responses to cytosolic dna 0.3064803804993958 0.0464360518925584 0.9629627022385951 1.0 1.0 3 Q9NZI8,P19474 2 Phase 0 rapid depolarisation 0.3676077265973273 0.04436560163907 0.964612980552793 1.0 1.0 2 Q13555 1 Mastl facilitates mitotic progression 0.282851262404758 0.0437152916413541 0.9651313499022742 1.0 1.0 5 Q96GX5 1 Interleukin 7 signaling 0.3652303120356631 0.0437021322355781 0.9651418395641898 1.0 1.0 2 P40763 1 Regulation of pten localization 0.3580980683506706 0.0418835681210057 0.9665915156428716 1.0 1.0 2 P46934 1 Pyroptosis 0.279595478881609 0.0409092160952457 0.9673682702179812 1.0 1.0 5 Q8WUX9,P09429,P04637,Q96FZ7 4 Trna modification in the nucleus and cytosol 0.2580141108344235 0.0403986717223971 0.9677752891983352 1.0 1.0 21 O75648,Q9NWX6,Q96FX7,P07814 4 Dissolution of fibrin clot 0.3346210995542368 0.0374641508486709 0.9701149235469946 1.0 1.0 2 P35237 1 Nrage signals death through jnk 0.2640713030041771 0.0369879886644889 0.9704945828452674 1.0 1.0 7 O75962 1 Nade modulates death signalling 0.2794292508917879 0.0350494534639546 0.9720403069139796 1.0 1.0 3 P42575,P62258 2 Rhoh gtpase cycle 0.2569506587553556 0.0342920310441163 0.9726442794395171 1.0 1.0 23 P27105,Q6IAA8,Q658Y4 3 Beta oxidation of lauroyl coa to decanoyl coa coa 0.2818911685994701 0.0324717934907659 0.97409580969683 1.0 1.0 4 P30084,Q16836,P40939 3 Beta oxidation of hexanoyl coa to butanoyl coa 0.2818911685994701 0.0324717934907659 0.97409580969683 1.0 1.0 4 P30084,Q16836,P40939 3 Protein ubiquitination 0.252227505037368 0.0214789518337259 0.9828635935934028 1.0 1.0 27 Q9BUN8,Q149N8 2 Cell death signalling via nrage nrif and nade 0.2476931193581057 0.02137032480775 0.9829502455307152 1.0 1.0 12 O75962,Q92974,Q92542 3 Metabolism of water soluble vitamins and cofactors 0.2522607591159729 0.0202184034329248 0.9838691470695992 1.0 1.0 41 Q4G0N4,Q9HC21,Q9H2D1,P43490,P78417,P00374 6 Transcriptional regulation by e2f6 0.2460835953880107 0.0185507818001516 0.9851994665040168 1.0 1.0 12 Q99496,P31350 2 Negative regulators of ddx58 ifih1 signaling 0.2461309523809545 0.0170939802927496 0.9863616412425136 1.0 1.0 7 P61086,Q86UT6,Q7Z434,Q96J02,Q9C037,Q15366 6 Translesion synthesis by polk 0.2498042406097575 0.0168385127959648 0.9865654454784364 1.0 1.0 10 P35251,P35250 2 Wax and plasmalogen biosynthesis 0.2270954157073121 0.0160123102937155 0.9872245707602654 1.0 1.0 4 Q8WVX9,Q6IAN0 2 Unwinding of dna 0.2421911740172358 0.0063467470775445 0.9949360624924412 1.0 1.0 10 Q9BRX5 1 Separation of sister chromatids 0.2640779784891576 0.0058734201598602 0.9953137156791968 1.0 1.0 110 P60900,P28074,P20618,P49721,Q7Z5K2,Q9UJX6,P28072,P61289,Q96DE5 9 Autophagy 0.2498125464503127 0.0031843968376099 0.9974592232218772 1.0 1.0 49 Q9Y4P1,P21796,Q9Y2Q5,Q99570,Q6IAA8,Q9NS69,P04350,P13473 8