Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Sphingolipid metabolism 0.7296427539342922 3.2769277467048883 0.0010494322061453 0.7693437089887087 0.6923221208805548 25 P51648,P06280,P16278,Q13510,P10619,Q96G23,Q06136,P07602,P04062,O95470,P17900 11 Protein localization 0.496607894546539 2.8852127135913777 0.0039114927689711 0.9958100657671168 0.6923221208805548 69 Q9NS69,P51648,O43615,O14925,O75746,Q9UJS0,Q2T9J0,Q9NR77,P09601,P56589,Q15067,P46379,P05067,Q5JRX3,Q10713,Q99595,P21796,P50402,O60830,Q9NX63,P34913,O00116,Q9Y276,O43933,Q13505,O15254,O15228,Q13190,Q9Y512,P12236,P06576 31 Slc mediated transmembrane transport 0.6470190007292451 2.5076237153257748 0.0121546024609979 0.9999999619367262 0.6923221208805548 19 Q15043,Q70HW3,Q99808,P30825,P12236,Q8TB61,Q9UBX3,P35613 8 Glycosphingolipid metabolism 0.7347302319807112 2.5012676855429063 0.0123749602639522 0.9999999721289768 0.6923221208805548 15 P06280,P16278,Q13510,P10619,P07602,P04062,P17900 7 Mitochondrial calcium ion transport 0.7083184522411613 2.4698593533042046 0.0135166183563664 0.9999999944612268 0.6923221208805548 16 Q9Y277,P21796,Q92667,Q9UJZ1,Q99623,Q8IYU8,P45880 7 Glycosaminoglycan metabolism 0.784589344944078 2.4654652158841044 0.013683546041147 0.9999999956273912 0.6923221208805548 12 P06865,P16278,P15586,P54802,Q7LGA3,O43505,Q8TB61 7 Mitochondrial protein import 0.590205190327858 2.421574086160188 0.0154534506805923 0.9999999996443298 0.6923221208805548 30 Q9NS69,Q5JRX3,Q13505,O43615,Q99595,P21796,O14925,O75746,Q9UJS0,Q9Y276,O60830,Q9NX63,Q9Y512,P12236,P06576 15 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.6757108743576151 2.4045088746054257 0.0161942130105448 0.999999999875722 0.6923221208805548 17 P05067,P14314,Q13217,P07237,Q86UP2,Q02818,O43852,Q15084,Q07065 9 Iron uptake and transport 0.6498414268862301 2.3803765182329113 0.0172949564064206 0.999999999973987 0.6923221208805548 18 Q93050,Q9UI12,P30519,P09601,Q15904,Q9Y487,P02786,Q658P3 8 Cristae formation 0.6194322217481194 2.3302876122744616 0.0197909550476285 0.9999999999992548 0.6923221208805548 19 P24539,Q13505,O75964,P56385,Q9NX63,Q6UXV4,P06576,Q16891 8 Sialic acid metabolism 0.8343571624966011 2.3019206482443284 0.0213396475451401 0.9999999999999182 0.6923221208805548 6 P16278 1 Pink1 prkn mediated mitophagy 0.8311674593086809 2.2882980472835603 0.0221201701591331 0.9999999999999732 0.6923221208805548 6 Q9NS69 1 Sphingolipid de novo biosynthesis 0.7793798949653568 2.285668657705242 0.0222736501855376 0.9999999999999784 0.6923221208805548 10 P51648,O95470,Q96G23 3 Transport of small molecules 0.5193599349267203 2.22124912453598 0.0263340926149646 1.0 0.6923221208805548 138 Q15043,Q8WTV0,Q93050,P30519,P08183,P09601,Q99623,Q8IYU8,P27105,P45880,P35613,P49721,Q9Y277,P21796,Q9HD20,Q92667,Q9BUN8,Q9UJZ1,Q15904,P28070,Q658P3,P16615,P61289,P51798,Q70HW3,Q9UI12,Q9C0H2,P30825,P20618,O95202,O75027,Q9Y487,Q9UBX3,Q9UL46,O15118,O00231,Q9BU23,P12236,Q9UEY8,P28072,Q8TB61 41 Glycerophospholipid biosynthesis 0.5460888180017681 2.1095266936818935 0.0348991443996515 1.0 0.6923221208805548 31 P35790,Q9BZF1,Q92604,Q96N66,Q8NCC3,Q8IV08,Q9NQZ5,Q9NPH0,Q53H12,O95674,Q8N2A8 11 Class a 1 rhodopsin like receptors 0.7626890736141196 2.0856408186686544 0.0370111709550111 1.0 0.6923221208805548 8 P07602,P42892,Q9BYT8 3 Peptide ligand binding receptors 0.7626890736141196 2.0856408186686544 0.0370111709550111 1.0 0.6923221208805548 8 P07602,P42892,Q9BYT8 3 Mitophagy 0.7462960574186965 2.0654405895777184 0.0388813313954448 1.0 0.6923221208805548 9 Q9NS69 1 Heme degradation 0.9024257841132448 2.056450991612854 0.0397390655536733 1.0 0.6923221208805548 4 P30519 1 Transport of inorganic cations anions and amino acids oligopeptides 0.7530668684899351 2.0413906702633815 0.0412120110643652 1.0 0.6923221208805548 8 P30825,Q70HW3 2 Keratan sulfate keratin metabolism 0.8319821930321182 2.027417959793517 0.0426196867542789 1.0 0.6923221208805548 5 P15586,P16278,O43505 3 Heparan sulfate heparin hs gag metabolism 0.8798691644364999 1.9684086330182535 0.0490210393817607 1.0 0.7133582501699971 4 P16278,P54802,Q7LGA3 3 Ion channel transport 0.5348322660512576 1.9269243015438433 0.0539890644511187 1.0 0.7618456872546754 24 Q9HD20,P51798,Q93050,Q9UI12,Q9C0H2,Q15904,P16615,P27105 8 Plasma lipoprotein clearance 0.6607279043462326 1.9106558353765015 0.0560488238922041 1.0 0.7825543201584675 13 Q8WTV0 1 Cholesterol biosynthesis 0.5674387320996542 1.8576969424020904 0.0632120629662664 1.0 0.8049172672561945 18 Q16850,Q9BWD1,Q15392,Q15800,Q15125,Q9UBM7 6 Phospholipid metabolism 0.4289377444532357 1.855534904715811 0.063519879584222 1.0 0.8049172672561945 52 Q8N9F7,P35790,Q9BZF1,O15228,Q92604,Q96N66,Q8NCC3,Q8IV08,Q9NQZ5,Q9NPH0,Q53H12,O95674,Q8N2A8 13 Class i peroxisomal membrane protein import 0.7200121802752822 1.841330567420337 0.0655731308809703 1.0 0.8049172672561945 7 P51648,O43808,Q9NR77,P56589,O75381 5 Mitotic telophase cytokinesis 0.6725558776290732 1.827445588970879 0.0676328001130861 1.0 0.8049172672561945 11 Q29RF7,Q7Z5K2,P53350,Q8N3U4 4 Trans golgi network vesicle budding 0.5022198191101739 1.825735109141717 0.0678901719801265 1.0 0.8049172672561945 34 P05067,O95295,P11717,O00203,Q12846,P15586,O60749,Q9Y5X1,P02786,P20645,Q9Y5X3,O75976,O14964 13 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.7808221796029569 1.8137034618962575 0.0697233918241808 1.0 0.8049172672561945 5 Q5KU26,P04439,P10321 3 Metabolism of porphyrins 0.7122633289072345 1.805740531878958 0.0709588783368482 1.0 0.8057650970004403 7 P30519 1 Synaptic adhesion like molecules 0.7057871324590875 1.7364517269153064 0.082483992827461 1.0 0.8454720214296958 6 O75955,Q14254,O95197,P41440 4 Ire1alpha activates chaperones 0.5094559664819813 1.7340278184423643 0.0829131474129336 1.0 0.8454720214296958 23 O95070,Q9Y5M8,Q13217,P49748,P49840,O14773,Q14203,Q15084,P43307,O76024 10 Lysosome vesicle biogenesis 0.6131558349173842 1.7299825297021425 0.0836333966094406 1.0 0.8459431474347014 14 P05067,P20645,P15586 3 Endosomal vacuolar pathway 0.8177222717811284 1.7224054119882115 0.0849961040001034 1.0 0.8459431474347014 4 P04439,Q9UIQ6,P10321 3 Keratan sulfate degradation 0.8119323749055857 1.6992556182584162 0.0892710309656261 1.0 0.8541892483491764 4 P15586,P16278 2 Cohesin loading onto chromatin 0.6753472687054306 1.6769006895055636 0.0935619033072729 1.0 0.8677179537651829 8 Q29RF7,Q7Z5K2,Q8N3U4 3 Establishment of sister chromatid cohesion 0.6802132647850733 1.6573730177610335 0.0974440830962852 1.0 0.8677179537651829 7 Q29RF7,Q7Z5K2,Q8N3U4 3 Cytoprotection by hmox1 0.3837018793771188 1.6541364964636134 0.0980997821066333 1.0 0.8677179537651829 65 Q14145,P49721,Q8TCT9,P61289,O00231,P13073,O43242,P30519,P09601,P20618,P28070,Q9UL46,P28072 13 Formation of atp by chemiosmotic coupling 0.6595290926249388 1.6478633053353553 0.0993807248406795 1.0 0.8677179537651829 9 O75964,P56385,P06576 3 Diseases of glycosylation 0.5312226074040177 1.6201139213459383 0.105207807477297 1.0 0.8907594366411152 18 P06865,P16278,Q9BT22,P10619,O43505,Q2TAA5 6 Wax and plasmalogen biosynthesis 0.7856745878508034 1.5938526986840589 0.1109690309701423 1.0 0.917300214587508 4 O15228,Q6IAN0 2 Intra golgi traffic 0.5579078402359496 1.5821595368478607 0.1136131549564303 1.0 0.9173420661373728 16 Q9UP83,O43752,O00461,O60476,O95721 5 Phosphorylation of emi1 0.7808504311626459 1.5744205638836146 0.1153902528082673 1.0 0.9173420661373728 4 P53350,P14635,Q12834 3 Plasma lipoprotein assembly remodeling and clearance 0.5712156913374142 1.5720928496116122 0.1159290195486892 1.0 0.9173420661373728 15 Q8WTV0,O15118 2 Transport of vitamins nucleosides and related molecules 0.6574434368402019 1.5509318533574583 0.1209180159036042 1.0 0.9286638635765856 7 P12236,Q8TB61 2 Signaling by erbb4 0.6557001994576003 1.542751390470965 0.1228911077264358 1.0 0.9305555145619674 7 P16949,P46934,Q92542 3 O linked glycosylation of mucins 0.7654497133664602 1.5122662209874569 0.1304661506284685 1.0 0.9305555145619674 4 Q10472,O43505 2 Mucopolysaccharidoses 0.9399524375743142 1.5088441479687589 0.1313386156665892 1.0 0.9305555145619674 3 P16278,P54802 2 O linked glycosylation 0.7092965033850069 1.5086692996322058 0.1313833148026115 1.0 0.9305555145619674 5 Q10472,O43505 2 Transferrin endocytosis and recycling 0.6106787960410284 1.507767995461028 0.1316139159860012 1.0 0.9305555145619674 11 Q93050,Q9UI12,Q15904,Q9Y487,P02786,Q658P3 6 Gpcr ligand binding 0.6207469505703125 1.5051052129486038 0.1322970290003577 1.0 0.9305555145619674 10 P07602,P42892,Q9BYT8 3 Aurka activation by tpx2 0.4687575707679561 1.5002687856235442 0.1335447916368823 1.0 0.9328103695836232 31 Q13561,Q9H6D7,O75935,O75330,Q9ULW0,P53350,O95684,P07900,Q99996,O94927,Q15154,Q96SN8 12 Stimuli sensing channels 0.6310417045727 1.4642513237119112 0.1431252916642318 1.0 0.948320816315662 8 Q9C0H2,P51798 2 Rhoa gtpase cycle 0.4059652929652854 1.4543150716048592 0.145858973794964 1.0 0.948320816315662 49 Q14739,P41440,P49257,Q86UP2,P51572,P30519,Q13190,P42166,Q96HY6,Q15904,O15173,P02786,O75955,P27105 14 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.5852900802085998 1.4323257070588002 0.152050629323176 1.0 0.948320816315662 12 P51648,P05067,Q13190,P09601,P46379 5 Metabolism of folate and pterines 0.6138401320226803 1.422426154519154 0.15490257489351 1.0 0.948320816315662 9 P00374,Q9H2D1 2 E2f enabled inhibition of pre replication complex formation 0.7413024085637787 1.4145198407071726 0.1572093260707898 1.0 0.948320816315662 4 P14635,P06493,Q9UBD5 3 Diseases of carbohydrate metabolism 0.6091085577288073 1.3989253972098734 0.1618353556929774 1.0 0.948320816315662 9 P54802,P15586,P16278 3 Synthesis of pc 0.6809488129789157 1.3863099531464518 0.1656522789371726 1.0 0.948320816315662 5 Q9NQZ5 1 Synthesis of pa 0.6057960766590236 1.382460002196669 0.1668305035476516 1.0 0.948320816315662 9 O15228,Q9NPH0,Q8N2A8 3 Ripk1 mediated regulated necrosis 0.575873487752093 1.381438672556397 0.1671441220628748 1.0 0.948320816315662 12 O15294,Q14254,P41440,Q16543,P07900,O75955,O00560 7 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.357331571613809 1.3736503764445849 0.1695502494598593 1.0 0.948320816315662 57 P24539,Q8N183,P13073,Q9P0J0,Q9UDW1,O75964,P56385,O43676,Q9NPL8,P06576,Q86Y39 11 Miscellaneous transport and binding events 0.6776721976907948 1.3721337568718113 0.1700218025012234 1.0 0.948320816315662 5 Q9H0U3,Q9UNS2,Q9UEY8 3 Purinergic signaling in leishmaniasis infection 0.6773737622525315 1.3708423269418055 0.1704241130663231 1.0 0.948320816315662 5 P09601 1 The nlrp3 inflammasome 0.6773737622525315 1.3708423269418055 0.1704241130663231 1.0 0.948320816315662 5 P09601 1 Inflammasomes 0.6773737622525315 1.3708423269418055 0.1704241130663231 1.0 0.948320816315662 5 P09601 1 Arachidonic acid metabolism 0.6111712418206371 1.3680617761874287 0.1712927400355903 1.0 0.948320816315662 8 Q9H7Z7,Q14914,Q15165 3 Binding and uptake of ligands by scavenger receptors 0.6109021811286524 1.3667567757264525 0.1717015552756096 1.0 0.948320816315662 8 Q8WTV0 1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.6627453184703815 1.3074987689594546 0.1910433727322202 1.0 0.9874511653096024 5 P05141,Q99808,P12236 3 Synthesis of pg 0.7145515873367815 1.3059992782804597 0.1915528030056565 1.0 0.9874511653096024 4 Q8IV08,Q8N2A8 2 Mitochondrial biogenesis 0.439465254735884 1.291104967425001 0.1966672818205352 1.0 0.9987163765365192 33 P24539,Q13505,O00411,Q5XKP0,O75964,Q9NX63,P56385,Q9BUR5,Q6UXV4,P06576,Q16891 11 Egr2 and sox10 mediated initiation of schwann cell myelination 0.5976962910313057 1.2686820458940595 0.2045544885008103 1.0 0.9987163765365192 7 Q16850 1 Response to elevated platelet cytosolic ca2 0.4410512793278568 1.2554574022206269 0.2093127625463877 1.0 0.9987163765365192 29 P05067,P13473,Q9NUQ9,Q08380,P07602,Q8NBX0,Q6UXV4 7 Mastl facilitates mitotic progression 0.6491458598852395 1.2485711014388146 0.2118219876191014 1.0 0.9987163765365192 5 Q96GX5,P14635 2 Diseases associated with glycosylation precursor biosynthesis 0.5865391377294834 1.2484059756745798 0.2118824217619141 1.0 0.9987163765365192 8 P16278 1 Rhobtb3 atpase cycle 0.693232884741229 1.2195202204818183 0.2226468059785762 1.0 0.9987163765365192 4 O60664 1 Tp53 regulates transcription of genes involved in cytochrome c release 0.8546373365041577 1.1925232823056937 0.2330561271839974 1.0 1.0 3 Q9Y255,Q658P3 2 Unwinding of dna 0.55556667809476 1.172090929017874 0.2411605513964851 1.0 1.0 10 P33991,Q9Y248,Q14566 3 Anchoring of the basal body to the plasma membrane 0.4290846340050212 1.1695647669105256 0.2421761630228458 1.0 1.0 30 Q13561,Q9H6D7,O75935,P53350,O95684,P07900,Q99996,O94927,Q15154,Q96SN8 10 Retrograde transport at the trans golgi network 0.4769973523259601 1.1640150865403185 0.2444178979333973 1.0 1.0 17 Q9UP83,O43752,O60664,Q9UID3,P53365,P20645 6 Synthesis of pips at the golgi membrane 0.571752075021795 1.1455210477783375 0.2519933816504192 1.0 1.0 7 Q9BTU6,Q10713,Q99570,O00443 4 Rac2 gtpase cycle 0.4160781568854024 1.1442059559639723 0.2525382336589301 1.0 1.0 36 Q9Y2A7,Q14739,Q13505,P49257,P50402,Q86XL3,Q6IAA8,Q9Y512,P42166,O15173,Q13177,P02786,P42167 13 Metabolism of cofactors 0.6219872463540942 1.1309875661182296 0.2580603248273787 1.0 1.0 5 P00374 1 Interleukin 4 and interleukin 13 signaling 0.5295980185179179 1.1305602561314876 0.2582402234607897 1.0 1.0 12 P40763,P04637,P08670,P09601,P07900 5 Nuclear signaling by erbb4 0.8323424494649188 1.110533006095533 0.2667694133997258 1.0 1.0 3 P16949,Q92542 2 Transport of bile salts and organic acids metal ions and amine compounds 0.83145065398335 1.1072650359393763 0.2681793563953749 1.0 1.0 3 P35613,Q15043 2 Cdc42 gtpase cycle 0.4099457531041911 1.0918057404370152 0.2749184953577799 1.0 1.0 36 Q14739,Q86UP2,Q9UQB8,Q6IAA8,P42166,P27105,Q13177,Q9NSV4,P02786,Q658P3,P42167 11 Insulin receptor recycling 0.5452999043011645 1.080977390504077 0.2797071710502967 1.0 1.0 9 Q9Y487,Q93050,Q9UI12,Q15904 4 Rac3 gtpase cycle 0.4126332878617872 1.069460213196178 0.2848623476458205 1.0 1.0 33 Q14739,P50402,Q9UQB8,P42166,O15173,P49257,P02786,Q9Y2A7 8 Activation of the pre replicative complex 0.4193269616484641 1.066080844862183 0.2863870978121812 1.0 1.0 20 Q99741,P56282,P33991 3 Constitutive signaling by ligand responsive egfr cancer variants 0.6038072575847809 1.0525494270080171 0.2925475459875568 1.0 1.0 5 P22681,P19174,Q16543,P07900 4 Signaling by egfr in cancer 0.6038072575847809 1.0525494270080171 0.2925475459875568 1.0 1.0 5 P22681,P19174,Q16543,P07900 4 Constitutive signaling by egfrviii 0.6038072575847809 1.0525494270080171 0.2925475459875568 1.0 1.0 5 P22681,P19174,Q16543,P07900 4 Hs gag degradation 0.9679049034175335 1.0467471810627285 0.2952161969402516 1.0 1.0 2 P16278 1 Depolymerisation of the nuclear lamina 0.5446208550650944 1.0447573673609836 0.29613512335616 1.0 1.0 8 P50402,P42167,P14635,P42166 4 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.8123697699260559 1.0376099378781607 0.2994516893426842 1.0 1.0 3 P67812 1 Synthesis secretion and deacylation of ghrelin 0.8123697699260559 1.0376099378781607 0.2994516893426842 1.0 1.0 3 P67812 1 Activation of nima kinases nek9 nek6 nek7 0.6480404859741005 1.037107713385275 0.2996856608158338 1.0 1.0 4 P53350,P14635 2 Rhod gtpase cycle 0.4114793849268581 1.0288334648619002 0.3035579382716085 1.0 1.0 30 Q14739,P50402,Q9UEY8,P42166,O15173,O60879,P49257,Q658P3 8 Rhof gtpase cycle 0.4139654974347014 1.0238678397948864 0.3058977022390889 1.0 1.0 21 O60879,P42166,Q9UEY8,Q658P3,P42167 5 Rnd2 gtpase cycle 0.4417778289524258 1.0219174957317811 0.3068199510327387 1.0 1.0 18 P51648,Q9BTT6,Q86UP2,Q9Y266,Q07065 5 Sulfur amino acid metabolism 0.5375447703592892 1.01051886873137 0.312246764031947 1.0 1.0 8 Q13126 1 Biosynthesis of specialized proresolving mediators spms 0.8030519673388 1.0038073929535722 0.3154714602573985 1.0 1.0 3 Q14914 1 Regulation of plk1 activity at g2 m transition 0.4012356254370412 1.0019814479131834 0.3163525530979247 1.0 1.0 35 Q13561,Q9H6D7,O14974,O75935,P14635,P53350,O95684,O94927,Q99996,Q15154 10 Cargo recognition for clathrin mediated endocytosis 0.4089076122290402 1.0009965949394255 0.3168284545894646 1.0 1.0 29 Q14108,Q9BT78,Q99627,P02786,P20645,O14964 6 Processing of smdt1 0.5135478466560128 0.9974398351658984 0.3185510637243307 1.0 1.0 11 Q96TA2,Q8IYU8,Q99623,Q9UJZ1 4 Dap12 interactions 0.5897222007436718 0.9920605697593716 0.3211679795939588 1.0 1.0 5 P01889,P10321 2 Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0.7986831189391306 0.9880135844946129 0.3231459952566955 1.0 1.0 3 Q96RR4 1 Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.5238950274316315 0.9747653288618712 0.329676678950394 1.0 1.0 9 Q99728,Q9UQ84,Q14191 3 Resolution of d loop structures 0.5238950274316315 0.9747653288618712 0.329676678950394 1.0 1.0 9 Q99728,Q9UQ84,Q14191 3 Metabolism of steroid hormones 0.5393883908639285 0.969990255695312 0.3320513492503787 1.0 1.0 6 P30536,Q14849 2 Condensation of prometaphase chromosomes 0.5226117227904092 0.9684216846189724 0.3328338140025857 1.0 1.0 9 Q15021,O95347,P14635,Q9NTJ3 4 Synthesis of substrates in n glycan biosythesis 0.4201955916066877 0.9682346941447322 0.3329271715373332 1.0 1.0 19 P16278 1 Recruitment of mitotic centrosome proteins and complexes 0.40068632766032 0.9603630281975308 0.336872538788366 1.0 1.0 32 Q13561,Q9H6D7,O75935,P53350,O95684,P07900,Q99996,O94927,Q15154,Q96SN8 10 Peptide hormone metabolism 0.4664804607534945 0.9477211552906394 0.3432714281859073 1.0 1.0 15 P67812,Q8TAG9,Q9UPT5,Q99626 4 Rho gtpases activate ktn1 0.5210638363100071 0.9311068101330572 0.3517983162180773 1.0 1.0 8 Q86UP2,Q9NSK0,Q9H0B6,Q07866 4 Interferon alpha beta signaling 0.5147445694854755 0.9296113348082904 0.3525723565736733 1.0 1.0 9 P04439,P61221,P10321 3 Golgi associated vesicle biogenesis 0.3991821778130849 0.9152755282758962 0.360047002790401 1.0 1.0 27 O95295,P11717,O00203,O60749,Q9Y5X1,P02786,Q9Y5X3,O75976 8 Intra golgi and retrograde golgi to er traffic 0.3573808298814278 0.8944854526571585 0.3710622097854608 1.0 1.0 96 P24390,P49755,Q9UID3,P53365,Q10471,P52732,Q07866,O60664,O00461,Q10472,O15260,O75935,O43752,P40616,Q9P2W9,Q8TD16,Q9Y3B3,Q9Y496,Q16706,Q13561,Q9UJW0,Q9UP83,Q13190,Q9BVK6,O60476,O95721,P20645 27 Incretin synthesis secretion and inactivation 0.5214143243643791 0.8877009993512315 0.3747016082091214 1.0 1.0 6 P67812,Q99626 2 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.5214143243643791 0.8877009993512315 0.3747016082091214 1.0 1.0 6 P67812,Q99626 2 Regulated necrosis 0.433792717848791 0.8870519538095583 0.3750509298218645 1.0 1.0 17 O15294,Q14254,P41440,P04637,P09429,Q16543,P07900,O75955,O00560 9 Organelle biogenesis and maintenance 0.3544644034537988 0.8869174461185769 0.3751233481267708 1.0 1.0 94 P24539,Q9H6D7,Q9UPT5,P50991,O75964,Q9BUR5,O95684,P07900,Q10713,Q9NX63,A6NIH7,Q99996,P53350,Q15154,A0AVF1,Q96SN8,Q5XKP0,O75935,P56385,Q92973,Q9Y496,Q13505,Q8TAG9,Q13561,O00411,Q9Y512,O94927,Q6UXV4,P06576,Q16891 30 Post translational modification synthesis of gpi anchored proteins 0.518265125436108 0.8733646373008259 0.3824643594432477 1.0 1.0 6 Q9H490,Q96S52 2 Regulation of hmox1 expression and activity 0.3559197489709994 0.8690326180016432 0.3848292901419625 1.0 1.0 47 Q14145,P49721,Q8TCT9,P61289,O00231,P09601,P20618,P28070,Q9UL46,P28072 10 Protein protein interactions at synapses 0.4631069836666893 0.8687672272446905 0.3849744620195792 1.0 1.0 14 Q14254,P41440,Q92796,O95197,O75955 5 Rhog gtpase cycle 0.379821719370161 0.8676200983919159 0.3856023400732402 1.0 1.0 38 Q14739,O95202,P49257,P50402,Q86UP2,Q86XL3,Q6IAA8,P61604,Q13190,P42166,O15173,Q13177,P02786,P42167 14 Ikk complex recruitment mediated by rip1 0.6038140616690153 0.8616626373254401 0.3888731914842638 1.0 1.0 4 Q13546 1 Initiation of nuclear envelope ne reformation 0.450216446130616 0.8518730065894986 0.39428458029843 1.0 1.0 15 Q14739,P50402,P14635,Q86XL3,P42166 5 Insulin processing 0.4985056346391842 0.8500245512543525 0.3953114366325194 1.0 1.0 9 O00471,Q8TAG9,Q9UPT5 3 Apc c cdc20 mediated degradation of cyclin b 0.4769158208155275 0.8472615522831892 0.3968493518082987 1.0 1.0 12 Q96DE5,P06493,P14635,Q12834,Q9UJX3,Q16763,Q9UJX4,Q9UJX6 8 Cilium assembly 0.3118731281458508 0.8442454126634544 0.3985322826211932 1.0 1.0 61 Q10713,Q13561,Q8TAG9,Q9H6D7,O75935,Q9UPT5,P50991,Q15154,A6NIH7,P53350,Q92973,O95684,O94927,Q99996,P07900,Q9Y496,A0AVF1,Q96SN8 18 G1 s specific transcription 0.4893346010864396 0.8356892673710055 0.4033297346778686 1.0 1.0 10 P00374 1 Phosphorylation of the apc c 0.4701396897670195 0.8114141829051144 0.417127856990438 1.0 1.0 12 Q96DE5,P06493,P14635,Q9UJX3,Q16763,P53350,Q9UJX4,Q9UJX6 8 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.3834316701444638 0.7949381865024528 0.4266494598234644 1.0 1.0 23 P10619,P16278,Q2TAA5 3 Cellular response to chemical stress 0.3240693177055497 0.7888438707303842 0.4302032648422833 1.0 1.0 75 Q14145,P49721,Q8TED1,Q8TCT9,P61289,O00231,P13073,O43242,P30519,P09601,P20618,P28070,Q9UL46,P28072 14 Switching of origins to a post replicative state 0.303527338909726 0.7882165514113426 0.4305700493070357 1.0 1.0 58 Q99741,P49721,Q96DE5,P61289,O00231,O43242,P33991,P20618,P28070,Q9UL46,P28072,Q9UJX6,Q14566 13 Cdc6 association with the orc origin complex 0.7410820451842988 0.784164070833495 0.4329438443664914 1.0 1.0 3 Q99741,Q9UBD5 2 Irak1 recruits ikk complex 0.7400009744979361 0.7804350778960912 0.4351348274019462 1.0 1.0 3 P51617 1 Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.4708693250246606 0.7767495220953491 0.4373065632588262 1.0 1.0 11 Q9UI12 1 Dna damage reversal 0.4961171800747562 0.7734423035911104 0.4392606620942674 1.0 1.0 6 P16455 1 Metabolism of steroids 0.3427835515262561 0.772473462558635 0.4398340584697706 1.0 1.0 48 Q16850,Q15392,Q15800,Q15125,P04062,Q9UBM7,P30536,Q14849 8 Pregnenolone biosynthesis 0.579346953367355 0.7669710715869685 0.4430987153565657 1.0 1.0 4 Q14849 1 Glutathione synthesis and recycling 0.4929986667041454 0.7595222328615225 0.4475402195467566 1.0 1.0 6 P48506,Q96KP4 2 Ticam1 rip1 mediated ikk complex recruitment 0.7274366002725235 0.7374222596855887 0.4608656029182132 1.0 1.0 3 Q13546 1 Attachment of gpi anchor to upar 0.56541871734342 0.7141281011865928 0.4751479708145338 1.0 1.0 4 Q9H490 1 Antigen presentation folding assembly and peptide loading of class i mhc 0.4261972543379264 0.7127316376936875 0.4760118351707387 1.0 1.0 15 P04439,Q9NZ08,P10321,P51572 4 Trafficking and processing of endosomal tlr 0.7181507252577385 0.7060460180662463 0.480159520236374 1.0 1.0 3 Q9H1C4 1 Dna replication pre initiation 0.3002576823220421 0.7056460419019932 0.4804082841455979 1.0 1.0 61 Q99741,P49721,P61289,O00231,O43242,P33991,P56282,P20618,P28070,Q9UL46,P28072 11 Ros and rns production in phagocytes 0.4724086585105207 0.7015036421957704 0.4829887624375186 1.0 1.0 8 Q9Y487,Q93050,Q9UI12 3 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.3704437961550447 0.6967483164614576 0.4859603156859398 1.0 1.0 26 P78417,Q13126,P14174,O00170,Q9UL46 5 Vxpx cargo targeting to cilium 0.463827601242571 0.6835847718997407 0.4942374033104437 1.0 1.0 9 Q8TAG9 1 Signaling by flt3 fusion proteins 0.5530776092774288 0.6680833303658956 0.5040804018832359 1.0 1.0 4 P62993,Q01082,Q9UBW7 3 Diseases associated with n glycosylation of proteins 0.509940059345052 0.6596321544287888 0.5094899146527161 1.0 1.0 5 Q2TAA5 1 Condensation of prophase chromosomes 0.4459989709889375 0.6519946604745699 0.5144046169543743 1.0 1.0 11 Q01105,O95347,P14635,P53350,Q9NTJ3 5 Amyloid fiber formation 0.4613305107766948 0.6508016787380178 0.5151745164172841 1.0 1.0 8 P05067 1 Striated muscle contraction 0.5068053449227881 0.6471344281679088 0.5175449449958542 1.0 1.0 5 Q9NYL9 1 Transcriptional regulation of white adipocyte differentiation 0.4145104863987555 0.6465059849189979 0.5179517224238328 1.0 1.0 15 Q9Y2W1,O75448,Q9NPJ6,Q71SY5 4 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.4505773819323977 0.6457132740042859 0.518465062434394 1.0 1.0 10 Q12834,Q9UJX6 2 Glutathione conjugation 0.4107034904538523 0.6251950233732744 0.5318430677805883 1.0 1.0 15 P78417,Q99735,Q96KP4,P48506 4 Synthesis of pips at the early endosome membrane 0.5008950797113976 0.6237341528357989 0.5328021898718238 1.0 1.0 5 Q9BTU6,Q99570,O00443 3 Tp53 regulates transcription of caspase activators and caspases 0.8344725111441311 0.6178571619984388 0.5366694992235197 1.0 1.0 2 P04637 1 Proton coupled monocarboxylate transport 0.8312035661218429 0.6081854051730345 0.5430645133131446 1.0 1.0 2 P35613 1 Metalloprotease dubs 0.4543229215689718 0.6032720994328838 0.5463276905457053 1.0 1.0 7 Q15018,Q99728,P38398 3 Regulation of tp53 activity through association with co factors 0.8255572065378906 0.591607676225092 0.5541133324028269 1.0 1.0 2 P04637 1 Synthesis of very long chain fatty acyl coas 0.4508968920978179 0.5883944228947894 0.5562675803238908 1.0 1.0 7 Q53GQ0 1 Diseases of immune system 0.5302722197932178 0.585269959098033 0.5583662109598184 1.0 1.0 4 P09429,Q9H1C4 2 Interleukin 12 signaling 0.3551411865925526 0.5851826485083601 0.5584249107111989 1.0 1.0 27 P78417,Q13126,P14174,O00170,Q9UL46 5 Potential therapeutics for sars 0.3488258961463599 0.5819555874829295 0.5605965965002175 1.0 1.0 36 Q14145,Q8WXI9,P62942,P08238,Q13464,Q99720,Q13546,P07900,P21964 9 Aryl hydrocarbon receptor signalling 0.6784685458206754 0.5766610192725458 0.5641684699900211 1.0 1.0 3 O00170 1 N glycan antennae elongation in the medial trans golgi 0.8196136701337302 0.5743380220411374 0.5657390844362329 1.0 1.0 2 P04066 1 Reactions specific to the complex n glycan synthesis pathway 0.8196136701337302 0.5743380220411374 0.5657390844362329 1.0 1.0 2 P04066 1 Plasma lipoprotein remodeling 0.8169390787518578 0.5666288479612114 0.570966371202762 1.0 1.0 2 Q9BU23 1 Abc family proteins mediated transport 0.3243276887847645 0.5655788290483477 0.5716801230102817 1.0 1.0 47 P49721,P61289,O00231,Q9BUN8,P08183,P20618,O75027,P28070,Q9UL46,P28072 10 Cd28 dependent pi3k akt signaling 0.816344725111442 0.5649210340410212 0.5721274761195123 1.0 1.0 2 P31751 1 Hyaluronan metabolism 0.521224786520776 0.5533563092162048 0.5800194501022851 1.0 1.0 4 P06865 1 Hyaluronan uptake and degradation 0.5212247865207758 0.5533563092162042 0.5800194501022855 1.0 1.0 4 P06865 1 Translation of sars cov 1 structural proteins 0.4415769940210269 0.5483909224925653 0.5834235080905783 1.0 1.0 7 Q10472,P49840 2 Signaling by fgfr in disease 0.3472931336464821 0.5479414039023656 0.5837321379771159 1.0 1.0 21 P30876,O95684 2 Interleukin 23 signaling 0.8092124814264492 0.5445816864118697 0.5860412530591086 1.0 1.0 2 P07237 1 Tnfr1 induced proapoptotic signaling 0.659896774848683 0.5192108766666508 0.6036136950450028 1.0 1.0 3 Q6GQQ9 1 P75ntr recruits signalling complexes 0.7991084695393765 0.5162723665461787 0.6056641934373097 1.0 1.0 2 P51617 1 Nrif signals cell death from the nucleus 0.7991084695393765 0.5162723665461787 0.6056641934373097 1.0 1.0 2 Q92542 1 Interleukin 12 family signaling 0.3443736603517597 0.5111320555415704 0.6092585911430606 1.0 1.0 30 P40763,P78417,Q13126,P07237,P26038,P14174,O00170,Q13177,Q9UL46 9 Aspartate and asparagine metabolism 0.4709184706150544 0.5088326133349171 0.6108695572545917 1.0 1.0 5 P08243,O75746 2 Suppression of phagosomal maturation 0.4307262617761199 0.5027635032675482 0.6151305562980771 1.0 1.0 7 Q9UI12 1 Rhoj gtpase cycle 0.3402672104421744 0.4952411886662256 0.6204298793662288 1.0 1.0 22 Q6IAA8,P42166,P27105,Q13177,P02786,Q658P3,P42167 7 Basigin interactions 0.4309570613425065 0.4944728356889867 0.6209722860889089 1.0 1.0 6 P53985,P35613 2 Orc1 removal from chromatin 0.3102390991684423 0.4878565811786308 0.6256514306349454 1.0 1.0 49 Q99741,P49721,P61289,O00231,O43242,P33991,P20618,P28070,Q9UL46,P28072 10 Platelet activation signaling and aggregation 0.3126257778521334 0.4831962521967921 0.6289563961784881 1.0 1.0 48 P05067,P13473,Q9NUQ9,Q08380,P07602,Q8NBX0,Q8N2K0,O43852,Q6UXV4,Q15833 10 Cargo trafficking to the periciliary membrane 0.3361833582176901 0.4806356078482645 0.6307755034694089 1.0 1.0 20 Q8TAG9,Q10713,Q9UPT5,P50991,A6NIH7 5 Traf6 mediated nf kb activation 0.4224355654790105 0.4801339737416997 0.631132132049476 1.0 1.0 8 P05067,Q9C037,P09429 3 Muscle contraction 0.3381715676399647 0.4763815197494425 0.633802598032281 1.0 1.0 23 P04083,P18206,P54709,P06753,Q13177,Q9NYL9,P08670,Q99996,P16615,Q05682 10 Ddx58 ifih1 mediated induction of interferon alpha beta 0.3738455321880476 0.4696415272650152 0.6386111502145937 1.0 1.0 16 P05067,Q86UT6,P09429,Q9C037,Q13546,P07900,P08238 7 Lipophagy 0.6365138853462331 0.4502596975986073 0.652523195546483 1.0 1.0 3 O60664 1 Signaling by insulin receptor 0.3779179666079192 0.448566850045544 0.6537441519151288 1.0 1.0 15 Q93050,Q9UI12,P21281,Q15904,Q9Y487 5 Unfolded protein response upr 0.3268945090840932 0.4407698576308538 0.6593796171977091 1.0 1.0 39 O95070,Q13217,P49748,Q15084,O14773,P08243,P43307 7 Role of phospholipids in phagocytosis 0.6327427391893348 0.4395266065991948 0.6602800075460871 1.0 1.0 3 Q8IV08 1 Diseases associated with glycosaminoglycan metabolism 0.6301976139107345 0.432347190450462 0.6654890939263187 1.0 1.0 3 P06865 1 Chondroitin sulfate dermatan sulfate metabolism 0.6301976139107345 0.432347190450462 0.6654890939263187 1.0 1.0 3 P06865 1 Rnd3 gtpase cycle 0.3490747041998899 0.4318785315770864 0.6658296987847663 1.0 1.0 18 Q86UP2,Q13464,Q9NYL9,Q9Y2I1,Q07065,O75976 6 E2f mediated regulation of dna replication 0.3976943030548867 0.4057054157802128 0.6849590624912247 1.0 1.0 10 O43913,P14635,P06493,Q9UBD5 4 Glucuronidation 0.616825208085605 0.3955072642825197 0.6924685616053587 1.0 1.0 3 Q16851,Q9NUJ1 2 Pi5p regulates tp53 acetylation 0.7471025260029726 0.3811345154970108 0.7031034371845786 1.0 1.0 2 P04637 1 Camk iv mediated phosphorylation of creb 0.4680897922465493 0.3796671756634205 0.7041924888582243 1.0 1.0 4 Q96RR4 1 Hdr through homologous recombination hrr 0.3252301913401343 0.3765953648488037 0.7064743329112098 1.0 1.0 28 P56282,Q9UQ84,P41440 3 The role of nef in hiv 1 replication and disease pathogenesis 0.3761466415004529 0.3750309410208139 0.707637455635655 1.0 1.0 13 P04439,Q9UI12 2 Tp53 regulates transcription of cell death genes 0.3926160218657574 0.3703827476829094 0.7110973265863123 1.0 1.0 9 Q9Y255,P04637,Q658P3 3 Abc transporters in lipid homeostasis 0.7417533432392283 0.3683487759399954 0.7126131872472019 1.0 1.0 2 P56589 1 Phase i functionalization of compounds 0.3674934121005143 0.3628823555273263 0.716692767877529 1.0 1.0 14 O00170,Q16850,O43169 3 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.603745541022584 0.3609784238410962 0.7181155764259715 1.0 1.0 3 P30153,Q14738 2 Pp2a mediated dephosphorylation of key metabolic factors 0.603745541022584 0.3609784238410962 0.7181155764259715 1.0 1.0 3 P30153,Q14738 2 Arms mediated activation 0.7378900445765237 0.3592549807576555 0.7194043494255495 1.0 1.0 2 Q9ULH0 1 Activation of smo 0.7361069836552757 0.3550980762076965 0.7225161178247381 1.0 1.0 2 Q9Y496 1 Regulation of signaling by cbl 0.6004756242568297 0.3525897786968173 0.7243960014923922 1.0 1.0 3 P62993,P22681 2 Signaling by erythropoietin 0.6004756242568282 0.3525897786968144 0.7243960014923945 1.0 1.0 3 P62993,P19174 2 Cargo concentration in the er 0.3684743249047386 0.3405369516847384 0.7334522003294164 1.0 1.0 13 P49755,Q96PC5,Q13190,Q12907,P49257,O95486 6 Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.3796037226686629 0.3314546809479037 0.7403010673941954 1.0 1.0 10 O95628,Q92600 2 Recruitment of numa to mitotic centrosomes 0.3156507381325655 0.3303231129036326 0.7411558305915336 1.0 1.0 36 Q13561,Q9H6D7,O75935,P53350,O95684,O94927,Q99996,Q15154 8 Complex i biogenesis 0.3174236642013012 0.3302946325232189 0.741177348211123 1.0 1.0 26 Q86Y39,Q8N183,O43676,Q9NPL8 4 Cell surface interactions at the vascular wall 0.3659390377905654 0.3293696694972493 0.7418762902064697 1.0 1.0 13 P54709,P14174,Q92896,P53985,P35613 5 Vitamin b5 pantothenate metabolism 0.4490581416160644 0.3243945553731724 0.7456393412585534 1.0 1.0 4 Q9NRN7,Q9NVE7 2 Biological oxidations 0.3016429764470964 0.3241526319247483 0.7458224817023045 1.0 1.0 45 Q99735,Q16850,O43169,P78417,O00170,Q96KP4,P21964,Q8TB61,P48506 9 Methylation 0.3796123199080565 0.3197288763229 0.7491738677668411 1.0 1.0 9 P78417,P21964 2 Diseases of dna repair 0.3556700329415873 0.3088295872397404 0.757451161193347 1.0 1.0 14 Q99728,Q14191,Q9UQ84,P43246 4 Role of second messengers in netrin 1 signaling 0.7153046062407141 0.3085349125606897 0.7576753387145432 1.0 1.0 2 P19174 1 Gap filling dna repair synthesis and ligation in gg ner 0.3164447146685283 0.3004312738296164 0.7638482117449985 1.0 1.0 19 P56282 1 Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0.406341405627279 0.2908355895384158 0.7711770647751703 1.0 1.0 5 Q9C037,Q13546 2 Maturation of sars cov 2 spike protein 0.3635044122947862 0.2821475033070161 0.777830409842132 1.0 1.0 11 Q16706,P04843,Q9H0U3,P14314,P46977 5 Dag and ip3 signaling 0.368981268706135 0.2733442326847198 0.7845886167047413 1.0 1.0 8 Q96RR4,P19174,P52292 3 Other interleukin signaling 0.4293976208285462 0.2718886048206841 0.7857076733383541 1.0 1.0 4 Q15833 1 Nr1h2 and nr1h3 mediated signaling 0.3985722784057136 0.2681161537791587 0.7886099119929253 1.0 1.0 5 P49327,O00767,Q9HCE1,Q9Y4C1 4 Rhoc gtpase cycle 0.3073546147900014 0.268100212901653 0.7886221819574899 1.0 1.0 35 Q14739,P41440,Q9NQW6,Q13464,Q13190,P42166,P27105,P49257,P02786,O75955,P42167 11 Fcgr3a mediated il10 synthesis 0.5635348880661544 0.2650967242848623 0.7909349507350603 1.0 1.0 3 P19174 1 Integrin signaling 0.4228367528992046 0.255480638467482 0.7983518958207081 1.0 1.0 4 P62993,P41240,P18031 3 Platelet aggregation plug formation 0.4228367528992046 0.255480638467482 0.7983518958207081 1.0 1.0 4 P62993,P41240,P18031 3 Retrograde neurotrophin signalling 0.3603335318642 0.2496884332722692 0.8028283038540762 1.0 1.0 9 O95782,Q96CW1,P53680,P50570,O94973,Q00610,P09496,Q9UQ16 8 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.3419301875386204 0.2496257777557966 0.8028767617861552 1.0 1.0 14 P05067,P09601 2 Ion transport by p type atpases 0.3606359573669431 0.2449708910386422 0.8064789703284834 1.0 1.0 8 Q9HD20 1 Smooth muscle contraction 0.3518476725006323 0.2382730226961679 0.8116693436222451 1.0 1.0 11 Q13177,P04083,Q05682,P18206 4 Pkmts methylate histone lysines 0.2971206381767307 0.2377240500969988 0.8120951290436187 1.0 1.0 21 Q9H7B4 1 Glycerophospholipid catabolism 0.6784546805349192 0.2352972029792455 0.8139780658893518 1.0 1.0 2 Q8N9F7 1 Interaction between l1 and ankyrins 0.4118346714243333 0.229277018818472 0.8186536140904221 1.0 1.0 4 O15020,Q13813,Q01082 3 Polo like kinase mediated events 0.3839326419667143 0.2277250485021735 0.8198599981277503 1.0 1.0 5 P14635 1 Selective autophagy 0.3018155754671336 0.2262516863592483 0.8210056727615753 1.0 1.0 30 Q9NS69 1 Golgi cisternae pericentriolar stack reorganization 0.3523873470221335 0.2227574776395646 0.8237242643752722 1.0 1.0 9 P14635,P06493,P53350,Q08379 4 Copi dependent golgi to er retrograde traffic 0.2776561077135305 0.2223040810184077 0.824077175393148 1.0 1.0 50 P24390,P33176,P52732,P49755,O60333,Q9H0B6,Q07866,Q14807,Q9P2W9,Q9Y3B3,Q9BVK6,Q9Y496,O15260,Q12981,Q9NSK0 15 P75 ntr receptor mediated signalling 0.3093023014490563 0.220557521971007 0.8254369790511944 1.0 1.0 18 Q13501,Q9NQC3,P42575,Q92542,P51617 5 Hedgehog on state 0.2922894883840248 0.2131136391868398 0.8312383264743404 1.0 1.0 42 P49721,P61289,O00231,O43242,Q2M1P5,Q9Y496,P20618,P28070,Q9UL46,P28072 10 Mitotic g1 phase and g1 s transition 0.2746623581173307 0.2115529380032177 0.8324558282503094 1.0 1.0 78 Q99741,P49721,P61289,O00231,O43242,P33991,P56282,P20618,P28070,Q9UL46,P28072,P00374,Q14566 13 Cd28 co stimulation 0.3507192978445004 0.210778536181596 0.8330600879231591 1.0 1.0 7 P42345,P31751 2 Peroxisomal protein import 0.2926520950075605 0.2067333766226454 0.8362180896615308 1.0 1.0 22 O15254,O15228,Q2T9J0,P34913,Q15067,O43933 6 Respiratory electron transport 0.2803775324082793 0.2058462095842492 0.8369110440361549 1.0 1.0 48 Q8N183,P13073,Q9UDW1,O43676,Q9NPL8,Q9P0J0,Q86Y39 7 Termination of translesion dna synthesis 0.2884776877155292 0.199470796472825 0.8418944853519021 1.0 1.0 20 P56282 1 Cdt1 association with the cdc6 orc origin complex 0.2917285191627232 0.1851445628629638 0.8531156496531069 1.0 1.0 39 Q99741,P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 8 Abc transporter disorders 0.2914779863023127 0.1835074478271794 0.8543998754827555 1.0 1.0 39 P49721,P61289,O00231,Q9BUN8,P20618,P28070,Q9UL46,P28072 8 Defective cftr causes cystic fibrosis 0.2914779863023127 0.1835074478271794 0.8543998754827555 1.0 1.0 39 P49721,P61289,O00231,Q9BUN8,P20618,P28070,Q9UL46,P28072 8 Coenzyme a biosynthesis 0.646953937592869 0.1826093221055356 0.8551045693580366 1.0 1.0 2 Q9NVE7 1 Antigen processing cross presentation 0.2725464531549659 0.1808179409317973 0.8565104804039201 1.0 1.0 50 P49721,Q9UIQ6,P61289,O00231,P10321,O43242,P09429,P04439,P20618,P28070,Q9UL46,P28072 12 Cardiac conduction 0.3386749240782957 0.1791764200536947 0.8577991781676528 1.0 1.0 9 Q99996 1 Pre notch expression and processing 0.3393300748797422 0.1783180585147742 0.8584731974468336 1.0 1.0 8 P16615,P04637 2 Meiotic synapsis 0.3187399253823808 0.1776202913337651 0.8590211877597644 1.0 1.0 15 O94901,P38398,Q14683,Q9UQE7,Q8N3U4,Q8WXH0 6 Metabolism of lipids 0.3788348385817381 0.172391018859644 0.8631301323930862 1.0 1.0 187 P51648,P06280,Q16850,P35790,P16278,Q9NPJ6,Q9BZF1,Q96N66,Q8NCC3,Q92604,Q06136,Q15165,Q15067,P42126,Q14849,Q14739,P50897,P10619,O43772,Q96G23,O75448,O60664,Q15125,Q8IV08,P34913,P04062,Q9UBM7,Q53H12,Q9H7Z7,Q9BWD1,Q71SY5,Q15392,P23786,Q9NPH0,P17900,Q53GQ0,P06865,Q13510,O15254,P49748,Q14914,Q15800,P07602,Q9NQZ5,O95470,P30536,Q8N2A8 47 Synthesis of pe 0.5117369202877263 0.1670057798953287 0.8673655010991248 1.0 1.0 3 P35790 1 Rhobtb1 gtpase cycle 0.2834110202001325 0.1663543374881198 0.8678781065776258 1.0 1.0 21 P08670,Q9BT78,Q5VTR2,P61201 4 Signaling by pdgfr in disease 0.3321170983379147 0.1593861129636076 0.8733646792991065 1.0 1.0 6 Q6UN15,P40763,Q8TAF3 3 Recognition of dna damage by pcna containing replication complex 0.2832506422129802 0.1585281228261853 0.8740406620365353 1.0 1.0 22 P56282 1 Vegfr2 mediated cell proliferation 0.6282317979197636 0.1557271614809335 0.8762480865919178 1.0 1.0 2 P19174 1 G2 m dna replication checkpoint 0.5042973859877723 0.1554006141047605 0.8765055000613915 1.0 1.0 3 P14635 1 Phase ii conjugation of compounds 0.2884052584876737 0.149520362509109 0.8811430430109226 1.0 1.0 30 Q99735,P78417,Q96KP4,P21964,Q8TB61 5 Signaling by braf and raf1 fusions 0.2821954335566985 0.1408609216533916 0.8879798142677313 1.0 1.0 24 Q99996,Q53H12,Q9NRY5 3 Sumoylation of dna methylation proteins 0.3672316384180896 0.1407639809463345 0.8880563987211296 1.0 1.0 4 P26358,Q99496,Q14781 3 Activation of rac1 downstream of nmdars 0.4939187646253714 0.1402573946224188 0.8884566256672677 1.0 1.0 3 Q96RR4 1 Beta catenin phosphorylation cascade 0.3241071428571451 0.1369656513903506 0.8910579454100314 1.0 1.0 7 P35222,P30153,P30154,P48729,Q16537,Q14738 6 Signaling by ctnnb1 phospho site mutants 0.3241071428571451 0.1369656513903506 0.8910579454100314 1.0 1.0 7 P35222,P30153,P30154,P48729,Q16537,Q14738 6 Disassembly of the destruction complex and recruitment of axin to the membrane 0.3241071428571451 0.1369656513903506 0.8910579454100314 1.0 1.0 7 P35222,P30153,P30154,P48729,Q16537,Q14738 6 Synthesis of dna 0.2716515049402602 0.1320741028997093 0.8949256793405269 1.0 1.0 83 Q99741,P49721,P61289,O00231,P41440,O43242,P33991,P56282,P20618,P28070,Q9UL46,P28072,Q9UJX6 13 Pcna dependent long patch base excision repair 0.2815754289844299 0.1286925303841437 0.8976009461492731 1.0 1.0 19 P56282 1 Degradation of axin 0.2843295096456418 0.1273055692388312 0.8986985525588556 1.0 1.0 36 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Cross presentation of soluble exogenous antigens endosomes 0.2843295096456418 0.1273055692388312 0.8986985525588556 1.0 1.0 36 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.2632647017464344 0.1272382142097078 0.898751860598185 1.0 1.0 51 P49721,Q96DE5,P61289,O00231,O43242,Q12834,P60900,P20618,P28070,Q9UL46,P28072,Q9UJX6 12 Apoptotic execution phase 0.2845002459628329 0.1268202902574299 0.8990826361017668 1.0 1.0 31 O76075,O00429,P26583,P09429,P51572,Q13464,P08670,Q9P289,Q9HAW4,Q13177,Q13813,P10412,Q16625 13 Shc1 events in erbb2 signaling 0.6032689450222897 0.124962750177089 0.9005530401759034 1.0 1.0 2 Q05655 1 Signaling by fgfr4 in disease 0.6032689450222896 0.1249627501770887 0.9005530401759037 1.0 1.0 2 P19174 1 Regulation of kit signaling 0.6032689450222896 0.1249627501770887 0.9005530401759037 1.0 1.0 2 P22681 1 Erythropoietin activates ras 0.6002971768202093 0.1216782690129302 0.9031538241529836 1.0 1.0 2 P62993 1 Rhobtb gtpase cycle 0.2824635921503803 0.1180373832822297 0.9060380373431024 1.0 1.0 30 Q9BT78,Q9NYL9,P08670,Q13464,Q5VTR2,P61201,Q16543,P07900 8 Regulation of tp53 expression and degradation 0.314643265536156 0.1139383670743448 0.9092866510665736 1.0 1.0 10 P42345,P31751,P04637 3 Leishmania infection 0.2792971577261113 0.1077431420947172 0.914199446242586 1.0 1.0 39 P09601,Q9UQB8 2 Regulation of ras by gaps 0.2800301540397136 0.1051188958274445 0.9162814656700368 1.0 1.0 37 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Degradation of dvl 0.2800301540397136 0.1051188958274445 0.9162814656700368 1.0 1.0 37 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Signaling by the b cell receptor bcr 0.2704022155357182 0.1047944622040762 0.9165389043757032 1.0 1.0 46 P49721,P62942,P61289,O00231,P20618,P28070,Q9UL46,P28072 8 Downstream signaling events of b cell receptor bcr 0.2718261953040469 0.1035827419436684 0.9175004839153846 1.0 1.0 45 P49721,P62942,P61289,O00231,P20618,P28070,Q9UL46,P28072 8 Regulation of innate immune responses to cytosolic dna 0.4586801426872633 0.0977188598891299 0.9221555392053136 1.0 1.0 3 P19474,Q9UJV9 2 Formation of senescence associated heterochromatin foci sahf 0.305011834368711 0.0894666492609555 0.9287110573006652 1.0 1.0 10 P04637,P10412 2 Interleukin 1 signaling 0.2621937288270773 0.086728698145051 0.9308871645390788 1.0 1.0 49 P05067,P49721,P61289,O00231,O43242,P20618,P51617,P28070,Q9UL46,P28072 10 Nf kb is activated and signals survival 0.4472223607225474 0.0867067891232759 0.930904579804924 1.0 1.0 3 P51617 1 P75ntr signals via nf kb 0.4472223607225474 0.0867067891232759 0.930904579804924 1.0 1.0 3 P51617 1 Apoptotic cleavage of cellular proteins 0.2713163371803644 0.086606334269742 0.93098443080309 1.0 1.0 19 P51572,Q13464,P08670,Q9P289,Q9HAW4,Q13813,Q16625 7 Ptk6 regulates rho gtpases ras gtpase and map kinases 0.3264942016057192 0.0851876231006884 0.9321122301470356 1.0 1.0 4 Q96JJ3,Q14185,Q9NRY4 3 Asymmetric localization of pcp proteins 0.2763816690459625 0.0847968247664341 0.9324229179191604 1.0 1.0 37 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Peroxisomal lipid metabolism 0.3000875680087517 0.082924276238896 0.9339117508695745 1.0 1.0 12 P51648,Q15067 2 Met activates ras signaling 0.317870948557843 0.0763593916114456 0.9391331760404384 1.0 1.0 4 P62993,Q96S59,Q96P70 3 Glycogen breakdown glycogenolysis 0.2984723635811244 0.0744563973197662 0.9406472347177046 1.0 1.0 9 P10253 1 Sting mediated induction of host immune responses 0.2924724784290423 0.0723103430684586 0.9423549336677384 1.0 1.0 6 P19474,P78527,Q9UJV9,P13010,P12956 5 Rora activates gene expression 0.4268727705112851 0.0702777108284747 0.9439726228172683 1.0 1.0 3 P50416,Q15648 2 Sumo is proteolytically processed 0.5346210995542364 0.0678270153797602 0.9459233381152126 1.0 1.0 2 Q9P0U3 1 Homology directed repair 0.2612537039444875 0.0672233853009128 0.9464038684528076 1.0 1.0 48 P41440,Q9UQ84,O96028,P56282,Q9UNS1 5 Sars cov infections 0.2382579329166016 0.066904370822043 0.9466578334246368 1.0 1.0 60 Q14145,Q16706,Q8WXI9,P21964,P62942,P49840,P04843,Q13464,Q99720,Q13546,P04844,Q10472,Q9H0U3,P07900,P14314,P08238,P46977 17 Golgi to er retrograde transport 0.2540660534294596 0.0665741128213712 0.9469207549878198 1.0 1.0 74 P24390,P33176,P49755,Q12981,Q10471,P52732,Q9H0B6,Q07866,Q10472,O15260,O75935,Q14807,Q9P2W9,Q8TD16,Q9Y3B3,Q9Y496,Q13561,Q9UJW0,O60333,O95239,Q9BVK6,Q9NSK0 22 Association of tric cct with target proteins during biosynthesis 0.272047025026529 0.0663941331022119 0.947064041004583 1.0 1.0 18 P04062,P04637,P50991 3 Signaling by notch4 0.2687862983443107 0.0614939878612225 0.950965802338364 1.0 1.0 42 P49721,P61289,O00231,Q92542,P20618,P28070,Q9UL46,P28072 8 Regulation by c flip 0.4131985731272175 0.0613109025797414 0.9511116081354232 1.0 1.0 3 Q13546,Q12933 2 Caspase activation via death receptors in the presence of ligand 0.4131985731272175 0.0613109025797414 0.9511116081354232 1.0 1.0 3 Q13546,Q12933 2 Advanced glycosylation endproduct receptor signaling 0.2909252332272816 0.0588214364125104 0.9530943342326066 1.0 1.0 9 P05067,P09429 2 Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 0.4048751486325661 0.0565968835928502 0.9548663171002544 1.0 1.0 3 P18887,P49916 2 Irf3 mediated induction of type i ifn 0.2923854848304488 0.0547669292120875 0.9563241475087324 1.0 1.0 5 P78527,P12956,Q9UJV9,P13010 4 Regulation of beta cell development 0.4006204967830874 0.054390841784606 0.9566237752525946 1.0 1.0 3 P31751 1 The activation of arylsulfatases 0.505200594353642 0.053679252295018 0.9571907132346952 1.0 1.0 2 O43681 1 Ngf stimulated transcription 0.5025260029717699 0.0526403042900464 0.95801850329179 1.0 1.0 2 P50570 1 Synthesis of pips at the er membrane 0.3947681331747815 0.0515703509562256 0.958871044401437 1.0 1.0 3 P42356,Q9NTJ5 2 Synthesis of pips at the late endosome membrane 0.3947681331747759 0.0515703509562228 0.9588710444014392 1.0 1.0 3 Q99570,O00443 2 G0 and early g1 0.2831157510164627 0.0512823608400907 0.959100523618844 1.0 1.0 7 Q99741,P06493 2 Uptake and function of diphtheria toxin 0.2841906972535048 0.0504969229375847 0.9597264014184376 1.0 1.0 4 P07900 1 Dissolution of fibrin clot 0.4861812778603284 0.0470725685205782 0.9624553902433548 1.0 1.0 2 P35237 1 Transcriptional regulation of pluripotent stem cells 0.3793533148937178 0.0452407153878037 0.9639154412707402 1.0 1.0 3 Q99626 1 Apc c mediated degradation of cell cycle proteins 0.234301377685927 0.0436529037234716 0.9651810807853488 1.0 1.0 59 P49721,Q96DE5,P61289,O00231,O43242,P14635,Q12834,P60900,P20618,P28070,Q9UL46,P28072,Q9UJX6 13 Vegfr2 mediated vascular permeability 0.2835394515899145 0.0427940691916861 0.9658656917597348 1.0 1.0 10 P07900,P42345,P31751 3 Rhoh gtpase cycle 0.2581833152784109 0.0416825706487336 0.9667517484921756 1.0 1.0 23 Q9UNZ2,Q13464,Q13177,P02786,P27105,Q99707 6 Dual incision in gg ner 0.2604417148265859 0.0386277277552688 0.9691871952335968 1.0 1.0 25 P56282 1 Degradation of gli1 by the proteasome 0.2667188380891378 0.0380526269162363 0.9696457221735332 1.0 1.0 39 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Sensory processing of sound by outer hair cells of the cochlea 0.2798921173827706 0.0375941940089496 0.9700112371609232 1.0 1.0 13 P35241,P15311,Q13813,P26038 4 Creb1 phosphorylation through the activation of adenylate cyclase 0.4326894502228846 0.0362637263837196 0.9710720730564086 1.0 1.0 2 P10644 1 Pka activation in glucagon signalling 0.4326894502228846 0.0362637263837196 0.9710720730564086 1.0 1.0 2 P10644 1 Pka mediated phosphorylation of creb 0.4326894502228846 0.0362637263837196 0.9710720730564086 1.0 1.0 2 P10644 1 Grb2 sos provides linkage to mapk signaling for integrins 0.4225854383358117 0.0351507648114881 0.971959521933575 1.0 1.0 2 P62993 1 Signaling by gpcr 0.2640192804578065 0.0347103194562687 0.9723107321508692 1.0 1.0 42 P05067,P42892,P31751,Q13464,P07602,Q96RR4,Q9BYT8,P52292,Q8N2K0 9 Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.3382721825493068 0.0346662004580064 0.9723459128460176 1.0 1.0 3 P06493 1 Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.4130757800891548 0.0342922690409905 0.972644089657106 1.0 1.0 2 O00767 1 Ra biosynthesis pathway 0.4089153046062425 0.0339674821526586 0.972903081212833 1.0 1.0 2 Q8NBN7 1 Free fatty acids regulate insulin secretion 0.3961367013372977 0.0331369039961845 0.9735654137661304 1.0 1.0 2 O95573 1 Dap12 signaling 0.3263971462544487 0.032893033399093 0.9737598883335276 1.0 1.0 3 P62993,P19174 2 Hdms demethylate histones 0.2740617639461594 0.0323207172065956 0.9742162878927882 1.0 1.0 8 Q9Y4C1 1 Maturation of sars cov 1 spike protein 0.2360987213797279 0.0321445192408546 0.974356800517943 1.0 1.0 4 Q13724,P27824,P14314 3 Activation of ppargc1a pgc 1alpha by phosphorylation 0.3316493313521566 0.0313525465468872 0.9749883848974692 1.0 1.0 2 P54619 1 Ionotropic activity of kainate receptors 0.2876671619613694 0.0311290983727907 0.9751665837640626 1.0 1.0 2 Q92796 1 Nrcam interactions 0.2876671619613694 0.0311290983727907 0.9751665837640626 1.0 1.0 2 Q92796 1 S phase 0.2734895688482665 0.0289971033373423 0.9768669008262316 1.0 1.0 96 Q13309,O43242,P33991,P60900,P62191,Q14566,P49721,P41440,P56282,P35251,P28070,Q99741,Q7Z5K2,P61289,Q29RF7,P11802,P31751,Q14683,Q9Y248,P20618,Q9UL46,Q8N3U4,Q9UBD5,Q96DE5,O00231,P51665,P28072,Q9UJX6 28 Ca dependent events 0.2714660280517161 0.0283858420824751 0.9773544160338116 1.0 1.0 8 Q96RR4 1 Signaling by vegf 0.2581072923670141 0.0242480544252975 0.980654747495155 1.0 1.0 26 P19174,P42345,P31751,Q9UQB8,Q13464,Q96F07,Q13177,P07900,Q9Y2A7 9 Metabolism of polyamines 0.2638639437079809 0.0217640114954774 0.9826362020488284 1.0 1.0 38 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Ub specific processing proteases 0.2523328392107892 0.0169458824709185 0.9864797890942734 1.0 1.0 78 Q14145,P49721,Q9Y277,P21796,P61289,O00231,O43242,P04637,Q12834,Q9UPT9,P20618,P28070,Q9UL46,P28072,P45880,O14964,Q96RU2 17 Diseases of mitotic cell cycle 0.2663668285791788 0.0154811320009331 0.9876483371724758 1.0 1.0 15 Q96DE5,P11802,Q9UJX3,Q16763,Q9UJX4,Q13309,Q9UJX6 7 Stabilization of p53 0.2621905564842869 0.0152568154177671 0.9878272947739212 1.0 1.0 39 P49721,P61289,O00231,O43242,P04637,P20618,P28070,Q9UL46,P28072 9 Rho gtpase cycle 0.3421632308348619 0.0139097521639134 0.9889019813813096 1.0 1.0 167 P51648,Q9BT78,Q86UP2,Q9UQB8,Q9NQW6,P30519,P08670,Q96HY6,P02786,O75955,P07900,P42167,P27105,O75976,Q14739,Q9UNZ2,P41440,P50402,Q9NYL9,Q9Y2I1,P61201,Q15904,P80723,Q658P3,O14964,Q14254,Q9BTT6,Q5VTR2,P42166,Q16543,O60879,Q13177,O95202,Q9Y2A7,Q13505,P49257,Q86XL3,P61604,Q13464,P51572,Q9Y512,Q6IAA8,Q9Y266,Q96F07,O15173,Q9UEY8,Q07065,Q13190,Q13813,Q99707 50 G1 s dna damage checkpoints 0.2600643490938101 0.0098760625986742 0.9921201702265204 1.0 1.0 41 P49721,P61289,O00231,O43242,P04637,P20618,P28070,Q9UL46,P28072 9 Hedgehog ligand biogenesis 0.2611660372346024 0.0088405557085872 0.9929463489715028 1.0 1.0 38 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Signaling by ptk6 0.2656428221966407 0.0081594450159602 0.9934897770351488 1.0 1.0 13 Q96JJ3,Q14185,P40763,P23246,P11802 5 Scf skp2 mediated degradation of p27 p21 0.2601281295120887 0.0073418872540567 0.9941420741398108 1.0 1.0 40 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.2642118120995992 0.0072680328064578 0.9942009998910512 1.0 1.0 11 Q96DE5,Q9UJX3,Q16763,Q9UJX4,Q13309,Q9UJX6 6 Regulation of runx3 expression and activity 0.2604995430668806 0.0050595364419645 0.9959630912115544 1.0 1.0 37 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Negative regulation of notch4 signaling 0.2599208334218581 0.004304826012746 0.996565256395998 1.0 1.0 39 P49721,P61289,O00231,P20618,P28070,Q9UL46,P28072 7 Regulation of pten stability and activity 0.2585708513974146 0.0024109256734808 0.9980763614914314 1.0 1.0 41 P49721,P61289,O00231,O43242,P20618,P28070,Q9UL46,P28072 8 Recycling of eif2 gdp 0.2443452380952401 0.0011232607694037 0.999103767762802 1.0 1.0 7 P20042,P49770,Q14232,Q13144,Q9NR50,P05198 6