Upload folder using huggingface_hub

interpro_active_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_active_site/basic/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_active_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:a4188bca67dfc6846c8092461200622e78e0a87966e9c1893fe106aad90a4535
+size 75021

interpro_active_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 55,
+    "title": "Average number of proteins per term",
+    "value": 2.8181818181818183
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C036/C036_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,6 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.976517230863066	2.017486632494528	0.0436447546364502	0.9140870896580908	0.4591880775160557	3	Q9HB40,Q9H3G5	2
+Cysteine peptidase, cysteine active site [IPR000169]	0.8039358915209753	1.945439200496737	0.0517221406047228	0.94611615390958	0.4591880775160557	6	P07858	1
+Cysteine peptidase, histidine active site [IPR025660]	0.9847560975609784	1.1348150619692312	0.2564528140343862	0.9999999164455878	0.7377768756156938	2	P07858	1
+Cysteine peptidase, asparagine active site [IPR025661]	0.9847560975609784	1.1348150619692312	0.2564528140343862	0.9999999164455878	0.7377768756156938	2	P07858	1
+Tyrosine-protein kinase, active site [IPR008266]	0.6058648948295038	0.9904811457637444	0.3219390002686664	0.9999999994754558	0.7377768756156938	5	Q15375,P07948	2

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "BUB1", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPN5", "CASP3", "CASP6", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CHEK2", "CIT", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK2A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAPK1", "MARK1", "MARK2", "MASTL", "MDH1", "MDH2", "MTM1", "MTMR2", "NCEH1", "NEK4", "NEK9", "NME1", "NME2", "NME3", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKACA", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1", "VRK2", "YES1"], "leading_proteins": ["CPVL", "CTSB", "EPHA7", "LYN", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_binding_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:cf5b3da9fca5e3a18e7322b842170f60b075501b8a5e8960ad2a045f11263731
+size 72647

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 30,
+    "title": "Average number of proteins per term",
+    "value": 4.866666666666666
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C036/C036_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Aryldialkylphosphatase, zinc-binding site [IPR017947]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "AURKA", "BPNT1", "BUB1", "CALM3", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CIT", "COX2", "COX5B", "CSK", "CSNK2A1", "CSNK2A2", "CYB5B", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "HPCAL4", "IDE", "ILKAP", "IMPA1", "INPP1", "IQGAP1", "LETM1", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK14", "MARK1", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NEK4", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1G", "PRKAA1", "PRKACA", "PRKCSH", "PSAT1", "PTER", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK24", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB6", "UBE3C", "UQCRC2", "VRK1", "YES1"], "leading_proteins": []}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "14-3-3 protein, conserved site [IPR023409]", "1": "DnaJ domain, conserved site [IPR018253]", "2": "AMP-binding, conserved site [IPR020845]", "3": "Mini-chromosome maintenance, conserved site [IPR018525]"}

interpro_conserved_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:8aa7205b2907d36bada76d93fda37fb7b9195e878765bed1df43884bbe30b44b
+size 82845

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 287,
+    "title": "Average number of proteins per term",
+    "value": 2.662020905923345
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C036/C036_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,41 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EGF-like calcium-binding, conserved site [IPR018097]	0.9328915830789366	1.859768851044602	0.0629182361284708	0.9999999920541826	0.5039033217842182	3	O94813	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7417666107840745	1.6916470074621277	0.0907132979888087	0.9999999999985968	0.5081707669227554	6	O15400,Q9P2W9,O60499	3
+Cadherin conserved site [IPR020894]	0.8251413220680767	1.4626048673524112	0.1435755306302273	1.0	0.6403022292763252	3	Q02487	1
+Proteasome beta-type subunit, conserved site [IPR016050]	0.6592399048810418	1.4026318666368782	0.1607266441190908	1.0	0.6884857740623743	8	P28072,P49721,P28070	3
+Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7587911014917843	2	P05067	1
+Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7587911014917843	2	P05067	1
+Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7587911014917843	2	P05067	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.9896341463414642	1.1512629609577931	0.2496240700505139	1.0	0.7587911014917843	2	Q9BTY2	1
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.9832317073170738	1.1296804561412153	0.2586108953384485	1.0	0.7587911014917843	2	P13473	1
+Tetraspanin, conserved site [IPR018503]	0.9826219512195128	1.1276273506429828	0.2594773308494438	1.0	0.7587911014917843	2	O60637	1
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.9774390243902448	1.1101934884867348	0.2669156580915914	1.0	0.7587911014917843	2	P01889	1
+Sugar transporter, conserved site [IPR005829]	0.9228658536585485	0.9290545664477012	0.3528608083915143	1.0	0.8510172437677699	2	Q7L0J3	1
+Cullin, conserved site [IPR016157]	0.5304830327929166	0.805226038946892	0.4206892529446733	1.0	0.9287524276547788	6	Q13618,Q13619,Q13617	3
+Sterol reductase, conserved site [IPR018083]	0.8496951219512281	0.6971356972749023	0.4857178760423597	1.0	0.9801092859071692	2	Q14739	1
+Alpha-D-phosphohexomutase, conserved site [IPR016066]	0.6127681133930515	0.6870680780026905	0.4920398291508741	1.0	0.9801092859071692	3	Q96G03	1
+Ribosomal protein L24/L26, conserved site [IPR005825]	0.829573170731724	0.6366286662929795	0.5243667482224352	1.0	0.9969102232450088	2	P61254	1
+FERM conserved site [IPR019747]	0.4626512797163057	0.5363294679761331	0.5917308680901272	1.0	1.0	6	P26038,O43491	2
+Ribosomal protein L24e, conserved site [IPR023442]	0.7618902439024684	0.4479746350391348	0.6541715026468409	1.0	1.0	2	Q9UHA3	1
+ABC transporter-like, conserved site [IPR017871]	0.4199313491299504	0.4064676518488198	0.6843990204807078	1.0	1.0	9	P08183,P61221	2
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.5059469350411853	0.3571020358412872	0.7210154204502448	1.0	1.0	3	O15347,P26583	2
+Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]	0.4200316472286205	0.3142571589894761	0.7533257333057484	1.0	1.0	5	P78527,O00443	2
+DNA ligase, ATP-dependent, conserved site [IPR016059]	0.6899390243902437	0.2808369990662492	0.7788354239885953	1.0	1.0	2	P18858	1
+Dynein light chain, type 1/2, conserved site [IPR019763]	0.6679878048780777	0.2382802326188927	0.8116637519465704	1.0	1.0	2	Q96FJ2	1
+Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]	0.4560096467174234	0.236733450126986	0.8128635830085684	1.0	1.0	3	Q14155	1
+Phosphofructokinase, conserved site [IPR015912]	0.4455626715462107	0.2150894650562897	0.8296975673581986	1.0	1.0	3	P08237,Q01813	2
+Short-chain dehydrogenase/reductase, conserved site [IPR020904]	0.346692065127282	0.1976098962813026	0.8433502913804782	1.0	1.0	13	Q06136,Q9BUT1	2
+Thioredoxin, conserved site [IPR017937]	0.3412830828087757	0.1669618178062354	0.8674000921327167	1.0	1.0	11	Q8IXB1,Q96JJ7,Q9H3N1	3
+RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]	0.6192073170731782	0.1593353811187871	0.8734046467158119	1.0	1.0	2	Q9Y2P8	1
+Ribosomal protein L30, conserved site [IPR018038]	0.6121951219512192	0.1497892448635618	0.880930894977008	1.0	1.0	2	Q6DKI1	1
+14-3-3 protein, conserved site [IPR023409]	0.33791208791209	0.1481169500898437	0.8822504727546228	1.0	1.0	6	P63104,P62258,P27348,P31946,Q04917	5
+GTP1/OBG, conserved site [IPR006074]	0.6027439024390348	0.1376343971036672	0.890529369266919	1.0	1.0	2	P55039	1
+Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]	0.5978658536585498	0.1316779737734064	0.8952390081757471	1.0	1.0	2	Q16539	1
+DnaJ domain, conserved site [IPR018253]	0.3181540342298242	0.106717752614427	0.9150128984859568	1.0	1.0	10	Q5F1R6,Q99543,Q9NVH1,P31689,P25685,Q9UBS4,O60884,Q96EY1,Q8WXX5	9
+RNA polymerase, beta subunit, conserved site [IPR007121]	0.5573170731707313	0.0902256797332783	0.928107878071626	1.0	1.0	2	Q9H9Y6	1
+AMP-binding, conserved site [IPR020845]	0.291386682956626	0.0572395640741755	0.9543543622335384	1.0	1.0	8	O60488,O14975,P33121,Q86V21,Q4G176,O95573,Q6P1M0	7
+GHMP kinase, ATP-binding, conserved site [IPR006203]	0.4966463414634142	0.0519582967322311	0.9585619228883652	1.0	1.0	2	Q03426	1
+Purine phosphorylase, family 2, conserved site [IPR018099]	0.4749999999999996	0.0438100985798401	0.9650557773117984	1.0	1.0	2	Q13126	1
+Mini-chromosome maintenance, conserved site [IPR018525]	0.2747252747252771	0.0393463844041831	0.968614225820788	1.0	1.0	6	P33992,P25205,Q14566,P49736,P33993	5
+Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]	0.3454268292682921	0.0271159103990119	0.978367284763446	1.0	1.0	2	O60573	1
+Polyamine biosynthesis domain, conserved site [IPR030373]	0.3335365853658531	0.0268805695697751	0.97855499115466	1.0	1.0	2	P19623	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Arrestin, conserved site [IPR017864]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "FeS cluster insertion, C-terminal, conserved site [IPR017870]", "Fibrillarin, conserved site [IPR020813]", "Folylpolyglutamate synthetase, conserved site [IPR018109]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamine synthetase, N-terminal conserved site [IPR027302]", "Glutamine synthetase, glycine-rich site [IPR027303]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycerate/sugar phosphate transporter, conserved site [IPR021159]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "GoLoco motif [IPR003109]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MnmG-related, conserved site [IPR020595]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Pseudouridine synthase, RluC/RluD, conserved site [IPR006224]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "Ribosome-binding factor A, conserved site [IPR020053]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AACS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABR", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APLP2", "APP", "ARHGEF7", "ARIH2", "ARRB2", "ARSA", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BDH2", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CIAO1", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DMD", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC2", "DSG2", "DST", "DTX3L", "DTYMK", "DUS1L", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPHA7", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FPGS", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GLUL", "GMPPA", "GMPPB", "GNB1", "GNB2", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPSM1", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HOXA10", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B8", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPA1", "IMPDH1", "IMPDH2", "ING5", "INPP1", "IQGAP1", "ISCA2", "IVD", "KDM2A", "KDM5C", "KDSR", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTO1", "MTOR", "MVK", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFM", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NOTCH2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PDSS1", "PEBP1", "PEPD", "PEX1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF2", "PHF3", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RASAL2", "RBFA", "RCL1", "RDH13", "RDX", "RIDA", "RIOK2", "RNF14", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RPUSD2", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLC37A4", "SLC5A6", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STMN1", "STRN", "STX10", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB6", "TUBG1", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP22", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["AACS", "ABCB1", "ABCE1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "APP", "ARHGEF7", "BDH2", "CUL2", "CUL3", "CUL4A", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC21", "DNAJC9", "DRG2", "DSC2", "DYNLL2", "EIF4E2", "EPB41L2", "FUCA2", "HLA-B", "HMGB2", "HMGB3", "KDSR", "LAMP2", "LBR", "LIG1", "MAPK14", "MCM2", "MCM3", "MCM5", "MCM6", "MCM7", "MSN", "MTAP", "MVK", "PFKM", "PFKP", "PGM2", "PIK3C2A", "POLR1B", "PRKDC", "PSMB2", "PSMB4", "PSMB6", "RCL1", "RPL26", "RPL7L1", "RSL24D1", "SLC27A2", "SLC27A4", "SLIT2", "SRM", "STX10", "STX18", "STX7", "SV2A", "TMX1", "TMX3", "TSPAN3", "YWHAB", "YWHAE", "YWHAH", "YWHAQ", "YWHAZ"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Immunoglobulin-like domain [IPR007110]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Immunoglobulin-like domain [IPR007110]", "1": "Importin-beta, N-terminal domain [IPR001494]", "2": "Ubiquitin-associated domain [IPR015940]", "3": "Phox homology [IPR001683]", "4": "14-3-3 domain [IPR023410]", "5": "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "6": "Pleckstrin homology domain [IPR001849]", "7": "AMP-dependent synthetase/ligase [IPR000873]", "8": "MCM N-terminal domain [IPR027925]", "9": "MCM OB domain [IPR033762]", "10": "MCM, AAA-lid domain [IPR041562]", "11": "MCM domain [IPR001208]", "12": "Proteasome component (PCI) domain [IPR000717]", "13": "Thioredoxin domain [IPR013766]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:1ef03cfcd1f7caa3848643b8cd6102560dcfd7a8a67e0f7e5e11396de36399f6
+size 184213

interpro_domain/df_merge.tsv

@@ -0,0 +1,7 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Immunoglobulin-like domain [IPR007110]	8	13	2.594979896168034	0.0094596451927497	4.480582524271845	12.427184466019416	0.4075261998509777	0.4433674298264088	2.6479725987944898	3.173316973839475	1.1756568118942026	0.3233613924696422	1.0	1.0	0.0248840898146938	0.0016592312888466	0.097972574862474
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	2	7	2.2168951226028364	0.0266302591421827	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	0.0244505537128122	0.0015075035399645	0.0058956460302812	0.00262770885776	0.018020673376298
+Aminopeptidase N-like , N-terminal domain [IPR045357]	1	5	2.1584484661502	0.0308929810027258	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0163643373684903	0.0385773062479974	0.0025659780541994	0.0148625463558957	0.0542215392640632
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	1	5	2.1584484661502	0.0308929810027258	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0163643373684903	0.0385773062479974	0.0025659780541994	0.0148625463558957	0.0542215392640632
+Immunoglobulin subtype 2 [IPR003598]	4	9	2.0190928903980483	0.0434775656770298	2.8106796116504853	8.04126213592233	0.1764352420775828	0.5005828106358552	2.0581551085254395	2.677802743524345	1.0491539805619012	0.3137632145774063	1.0	1.0	0.4895400608205746	0.0242455864981032	0.2339293848293204
+Immunoglobulin subtype [IPR003599]	4	9	2.019092890398044	0.0434775656770303	2.9684466019417477	8.483009708737864	0.1381371967634491	0.4928258967784709	2.271921156707309	2.9216637549507847	1.0756254869730633	0.312999744433737	1.0	1.0	0.6173373514085678	0.086260584657332	0.51095089307192

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 2673,
+    "title": "Average number of proteins per term",
+    "value": 2.182566404788627
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C036/C036_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,261 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Immunoglobulin-like domain [IPR007110]	0.8733374561488751	2.594979896168034	0.0094596451927497	0.9999999999907462	0.4855274124481779	13	P35613,Q13740,P04439,P10321,Q9Y624,Q08722,P78310,P01889	8
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.8621224621092154	2.2168951226028364	0.0266302591421827	1.0	0.4855274124481779	7	Q8WUJ1,Q9UMX5	2
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8993685333454943	2.1584484661502	0.0308929810027258	1.0	0.4855274124481779	5	Q9UIQ6	1
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8993685333454943	2.1584484661502	0.0308929810027258	1.0	0.4855274124481779	5	Q9UIQ6	1
+Major facilitator superfamily domain [IPR020846]	0.910571002156056	2.093159363948442	0.0363349308789502	1.0	0.4855274124481779	4	Q7L0J3,O43826	2
+Immunoglobulin V-set domain [IPR013106]	0.8948371159664177	2.033754944739264	0.0419763092972513	1.0	0.4855274124481779	4	Q9Y624,P78310	2
+Immunoglobulin subtype 2 [IPR003598]	0.7929538491478219	2.0190928903980483	0.0434775656770298	1.0	0.4855274124481779	9	P35613,Q9Y624,Q13740,P78310	4
+Immunoglobulin subtype [IPR003599]	0.7929538491478215	2.019092890398044	0.0434775656770303	1.0	0.4855274124481779	9	P35613,Q9Y624,Q13740,P78310	4
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.9768222018908206	2.0185816644263297	0.0435307183509086	1.0	0.4855274124481779	3	P04439,P01889	2
+Immunoglobulin C1-set [IPR003597]	0.9768222018908206	2.0185816644263297	0.0435307183509086	1.0	0.4855274124481779	3	P04439,P01889	2
+MHC class I, alpha chain, C-terminal [IPR010579]	0.9768222018908206	2.0185816644263297	0.0435307183509086	1.0	0.4855274124481779	3	P04439,P01889	2
+MHC class I-like antigen recognition-like [IPR011161]	0.9768222018908206	2.0185816644263297	0.0435307183509086	1.0	0.4855274124481779	3	P04439,P01889	2
+ERAP1-like C-terminal domain [IPR024571]	0.967828709507738	1.9862445837480909	0.0470061725950505	1.0	0.4855274124481779	3	Q9UIQ6	1
+Ricin B, lectin domain [IPR000772]	0.8397847474481095	1.9290429225892136	0.0537255338598721	1.0	0.4855274124481779	5	Q10471,Q10472,Q9UBG0	3
+EGF-like domain [IPR000742]	0.9328915830789366	1.859768851044602	0.0629182361284708	1.0	0.4855274124481779	3	O94813	1
+EGF-like calcium-binding domain [IPR001881]	0.9328915830789366	1.859768851044602	0.0629182361284708	1.0	0.4855274124481779	3	O94813	1
+Tim10-like [IPR004217]	0.9197926197011256	1.812015927766396	0.0699837354587336	1.0	0.4855274124481779	3	O60220,Q9Y5J9	2
+MRH domain [IPR044865]	0.916168445446384	1.7987734706629126	0.0720545214923249	1.0	0.4855274124481779	3	P11717	1
+U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]	0.8311189244127927	1.789683694054115	0.0735047752073267	1.0	0.4855274124481779	4	Q15435,P39687	2
+KOW [IPR005824]	0.7964004897813135	1.758681646034968	0.0786315965441817	1.0	0.4884595308736671	5	P61353,P61254	2
+Linker histone H1/H5, domain H15 [IPR005818]	0.7560724357785003	1.7505822614694253	0.0800178929873594	1.0	0.4884595308736671	6	P10412,Q92522,P07305,P16402	4
+Peptidase M28 [IPR007484]	0.8970769739681932	1.7288079674192856	0.0838434697231966	1.0	0.4884595308736671	3	P02786	1
+Cyclic nucleotide-binding domain [IPR000595]	0.7630158645179759	1.625876695118032	0.1039758886947215	1.0	0.5168898387688234	5	Q8TEU7,Q9Y4G8,P10644	3
+W2 domain [IPR003307]	0.7110519774540173	1.5942481642925324	0.1108804626622688	1.0	0.5286550729942827	7	P55010	1
+Fibronectin type II domain [IPR000562]	0.8604032825011156	1.5935307265609835	0.1110411809484137	1.0	0.5286550729942827	3	P11717	1
+N-acetylgalactosaminyltransferase [IPR045885]	0.8533089356511137	1.567247133465752	0.1170569372427241	1.0	0.5398622128949323	3	Q10471,Q10472	2
+CBS domain [IPR000644]	0.7016970968463958	1.554515854043608	0.1200614179423551	1.0	0.5430189004397891	7	P51798,P51790,P54619,Q8NE01	4
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.7580698382485069	1.5039131082558654	0.1326037413965428	1.0	0.5698557132346076	4	P27544,Q15629	2
+Cold-shock (CSD) domain [IPR019844]	0.829335092144044	1.478209351533679	0.1393517516331015	1.0	0.5723220205122808	3	P67809	1
+Cold-shock protein, DNA-binding [IPR002059]	0.829335092144044	1.478209351533679	0.1393517516331015	1.0	0.5723220205122808	3	P67809	1
+Cold shock domain [IPR011129]	0.829335092144044	1.478209351533679	0.1393517516331015	1.0	0.5723220205122808	3	P67809	1
+Cadherin-like [IPR002126]	0.8251413220680767	1.4626048673524112	0.1435755306302273	1.0	0.5779041180401735	3	Q02487	1
+Methyltransferase type 11 [IPR013216]	0.8209820067093544	1.4471216826418891	0.1478628462352325	1.0	0.5838070723586063	3	Q8N6R0,O43709	2
+GNAT domain [IPR000182]	0.6821793524677683	1.4432330450356172	0.1489548336947088	1.0	0.5872511363804672	6	Q86UY6	1
+Cyclin-like [IPR013763]	0.7696227448936194	1.2556643412612276	0.2092376928957988	1.0	0.6872362148965355	3	P06400	1
+Syntaxin, N-terminal domain [IPR006011]	0.7566660510546555	1.2074004125889957	0.2272779767350408	1.0	0.7198482906873137	3	O15400	1
+Zinc finger, UBR-type [IPR003126]	0.7554504924294889	1.2028758003902127	0.2290243862541001	1.0	0.7198482906873137	3	Q8N806	1
+FERM, N-terminal [IPR018979]	0.6539099103026442	1.1849103692139349	0.2360528871549845	1.0	0.7198482906873137	5	P26038,O43491	2
+FERM, C-terminal PH-like domain [IPR018980]	0.6539099103026442	1.1849103692139349	0.2360528871549845	1.0	0.7198482906873137	5	P26038,O43491	2
+Amyloidogenic glycoprotein, extracellular [IPR008154]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7198482906873137	2	P05067	1
+Amyloidogenic glycoprotein, copper-binding [IPR011178]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7198482906873137	2	P05067	1
+Amyloidogenic glycoprotein, heparin-binding [IPR015849]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7198482906873137	2	P05067	1
+Amyloidogenic glycoprotein, E2 domain [IPR024329]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7198482906873137	2	P05067	1
+Pancreatic trypsin inhibitor Kunitz domain [IPR002223]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7198482906873137	2	P05067	1
+Beta-amyloid precursor protein C-terminal [IPR019543]	0.997256097560976	1.1770120257422194	0.2391907063934977	1.0	0.7198482906873137	2	P05067	1
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.7477889600487861	1.1743749245861688	0.2402448845357518	1.0	0.7198482906873137	3	Q96F07,Q7L576	2
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.9896341463414642	1.1512629609577931	0.2496240700505139	1.0	0.7312275467178858	2	Q9BTY2	1
+Glycoside hydrolase family 20, catalytic domain [IPR015883]	0.9868902439024402	1.142007851117955	0.2534507562542165	1.0	0.7312275467178858	2	P06865	1
+Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]	0.9868902439024402	1.142007851117955	0.2534507562542165	1.0	0.7312275467178858	2	P06865	1
+PA domain [IPR003137]	0.985060975609758	1.135842295645947	0.2560225720636926	1.0	0.7327069969231802	2	P02786	1
+Peptidase C1A, papain C-terminal [IPR000668]	0.9847560975609784	1.1348150619692312	0.2564528140343862	1.0	0.7331533389453629	2	P07858	1
+Cysteine-rich flanking region, C-terminal [IPR000483]	0.983536585365854	1.1307071676035574	0.2581783635375152	1.0	0.7349422425301152	2	O94813	1
+Leucine-rich repeat N-terminal domain [IPR000372]	0.983536585365854	1.1307071676035574	0.2581783635375152	1.0	0.7349422425301152	2	O94813	1
+MD-2-related lipid-recognition domain [IPR003172]	0.9817073170731716	1.1245484921427915	0.2607804108081599	1.0	0.739985178439715	2	P17900	1
+EXPERA domain [IPR033118]	0.978353658536586	1.11326772556221	0.2655934633565926	1.0	0.7460209501780367	2	Q5BJF2	1
+Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]	0.5909333264406649	1.0577285159965348	0.2901792307804518	1.0	0.7733290965863885	6	O14578,Q13464	2
+PTB/PI domain [IPR006020]	0.6221356541376786	1.0561098386925225	0.2909180359179473	1.0	0.7737551343369882	5	Q5SW96,Q5R372	2
+Glycosyltransferase 2-like [IPR001173]	0.6207836106053659	1.0506450284124704	0.2934216521525563	1.0	0.7759058340807473	5	Q8N4A0,Q10471,Q10472	3
+Marvel domain [IPR008253]	0.9585365853658536	1.046905506696907	0.2951431618628362	1.0	0.7780253172183048	2	O43760	1
+v-SNARE, coiled-coil homology domain [IPR042855]	0.7065519039931452	1.021789979388309	0.306880313086431	1.0	0.7940862312488192	3	P51809	1
+Longin domain [IPR010908]	0.7065519039931452	1.021789979388309	0.306880313086431	1.0	0.7940862312488192	3	P51809	1
+Exportin-1/Importin-beta-like [IPR013598]	0.6076849081785314	0.9978058812161388	0.3183734977707178	1.0	0.800444141863119	5	O43592,Q96QU8,Q9Y5L0	3
+Target SNARE coiled-coil homology domain [IPR000727]	0.56327927508746	0.9817079280453536	0.3262437585184905	1.0	0.8031724970641463	8	O15400,O60499	2
+Ras-associating (RA) domain [IPR000159]	0.566140400191126	0.9533974567817896	0.3403887295105303	1.0	0.8234018769064684	6	Q8TEU7,Q15036,Q9Y4G8	3
+ERM family, FERM domain C-lobe [IPR041789]	0.684022606527014	0.939364585945862	0.3475435889421252	1.0	0.8333369119942261	3	P26038	1
+Citron homology (CNH) domain [IPR001180]	0.91890243902439	0.916115196130564	0.3596064782972212	1.0	0.8414336374273799	2	Q8WUH2	1
+Chromo domain subgroup [IPR017984]	0.6758157974992147	0.9095763478986124	0.3630459768363376	1.0	0.8430198594907132	3	Q13185,P83916	2
+Chromo shadow domain [IPR008251]	0.6758157974992147	0.9095763478986124	0.3630459768363376	1.0	0.8430198594907132	3	Q13185,P83916	2
+HR1 rho-binding domain [IPR011072]	0.5849859093994245	0.9068369868543492	0.3644930074657246	1.0	0.8430198594907132	5	Q15642,Q13464	2
+Phospholipase D/Transphosphatidylase [IPR001736]	0.9152439024390364	0.9042026574317164	0.3658879513417052	1.0	0.8437985637032634	2	Q8IV08	1
+JmjC domain [IPR003347]	0.548605378448689	0.8976234527215812	0.3693863313778993	1.0	0.8497929657642743	7	Q9Y2K7,P41229,O75151	3
+Exportin-2, central domain [IPR013713]	0.6724938193701783	0.8975604868871966	0.3694199125395012	1.0	0.8497929657642743	3	O95373	1
+Importin-beta, N-terminal domain [IPR001494]	0.497226959523132	0.8956314055928292	0.3704496566632604	1.0	0.8514290045235556	15	Q96QU8,Q96P70,O95373,Q92973,Q9UI26,O43592,O15397,Q14974,Q9UIA9	9
+Ubiquitin-associated domain [IPR015940]	0.4955992019728208	0.8873860991089969	0.374871064965208	1.0	0.8553569429403753	15	Q9Y5A7,Q04323,Q9NRR5,Q8NBM4,Q13501	5
+Helicase/UvrB, N-terminal [IPR006935]	0.6594435238535767	0.8506161266497962	0.394982628155671	1.0	0.8810761298061218	3	Q92900	1
+Tyrosine-protein kinase, catalytic domain [IPR020635]	0.59215111650744	0.8498957471758111	0.3953830502324003	1.0	0.8810761298061218	4	Q15375	1
+Cullin protein, neddylation domain [IPR019559]	0.5304830327929166	0.805226038946892	0.4206892529446733	1.0	0.8974835395434593	6	Q13618,Q13619,Q13617	3
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.646233607807273	0.8035725363133414	0.4216438894308889	1.0	0.8987672379974212	3	Q16134,P61221	2
+RNA recognition motif domain, eukaryote [IPR003954]	0.5040730649690861	0.7928852030382672	0.4278447091157569	1.0	0.9055689260480468	11	Q9UHX1,Q14011	2
+FCH domain [IPR001060]	0.6413415712446837	0.7862872627964789	0.431699212868343	1.0	0.9058452525375416	3	Q15642	1
+F-BAR domain [IPR031160]	0.6413415712446837	0.7862872627964789	0.431699212868343	1.0	0.9058452525375416	3	Q15642	1
+Zinc finger, FYVE-related [IPR017455]	0.5637426628168226	0.74202436036485	0.4580725762679474	1.0	0.9193685482085814	4	O14964	1
+FYVE zinc finger [IPR000306]	0.5637426628168226	0.74202436036485	0.4580725762679474	1.0	0.9193685482085814	4	O14964	1
+Glutamine amidotransferase [IPR017926]	0.5637318264447072	0.7419837630083704	0.4580971733196604	1.0	0.9193685482085814	4	Q9NRF8,P17812	2
+Sterile alpha motif domain [IPR001660]	0.5110496302161087	0.7401549660722083	0.4592059696298891	1.0	0.9193685482085814	7	Q15375,Q6UWE0	2
+Zinc finger, TFIIB-type [IPR013137]	0.8554878048780669	0.7148602734488994	0.4746953867690082	1.0	0.9193685482085814	2	P29083	1
+ELMO domain [IPR006816]	0.8536585365853815	0.7092490806837779	0.47816992080649	1.0	0.9193685482085814	2	Q96JJ3	1
+Dbl homology (DH) domain [IPR000219]	0.534497366906247	0.7091007430752571	0.4782619618804635	1.0	0.9193685482085814	5	Q92974,Q14155	2
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]	0.6127681133930515	0.6870680780026905	0.4920398291508741	1.0	0.9303853001023084	3	Q96G03	1
+Ribosomal protein L26/L24, KOW domain [IPR041988]	0.829573170731724	0.6366286662929795	0.5243667482224352	1.0	0.940768255289426	2	P61254	1
+Exoribonuclease, phosphorolytic domain 2 [IPR015847]	0.4878647771338048	0.6335187185338053	0.5263949610765213	1.0	0.940768255289426	6	Q96B26,Q15024	2
+RNA polymerase, alpha subunit [IPR000722]	0.5928636779506046	0.6200463012539862	0.5352273041151592	1.0	0.9430867395516286	3	O95602,P24928	2
+RNA polymerase Rpb1, domain 3 [IPR007066]	0.5928636779506046	0.6200463012539862	0.5352273041151592	1.0	0.9430867395516286	3	O95602,P24928	2
+RNA polymerase Rpb1, domain 5 [IPR007081]	0.5928636779506046	0.6200463012539862	0.5352273041151592	1.0	0.9430867395516286	3	O95602,P24928	2
+RNA polymerase Rpb1, domain 4 [IPR007083]	0.5928636779506046	0.6200463012539862	0.5352273041151592	1.0	0.9430867395516286	3	O95602,P24928	2
+RNA polymerase, N-terminal [IPR006592]	0.5928636779506046	0.6200463012539862	0.5352273041151592	1.0	0.9430867395516286	3	O95602,P24928	2
+RNA polymerase Rpb1, domain 1 [IPR007080]	0.5928636779506046	0.6200463012539862	0.5352273041151592	1.0	0.9430867395516286	3	O95602,P24928	2
+Sec23, C-terminal [IPR037550]	0.8216463414634145	0.6132816295096399	0.5396901380713701	1.0	0.9435129125872828	2	Q15437	1
+Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]	0.8204268292682926	0.6097159151138557	0.5420500100394028	1.0	0.9435129125872828	2	Q01658	1
+Gamma-glutamyl cyclotransferase-like [IPR013024]	0.8131097560975609	0.588473163932375	0.5562147415145893	1.0	0.947609909915837	2	Q8WUX2	1
+Dynein heavy chain, coiled coil stalk [IPR024743]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain, ATP-binding dynein motor region [IPR035706]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain, C-terminal domain [IPR041228]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain, tail [IPR013594]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain AAA lid domain [IPR041658]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain, linker [IPR013602]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain region D6 P-loop domain [IPR004273]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+Dynein heavy chain, AAA module D4 [IPR024317]	0.8112804878048878	0.5832039460132071	0.5597560150931384	1.0	0.947609909915837	2	Q8NCM8	1
+PB1 domain [IPR000270]	0.8088414634146582	0.5762047416470666	0.5644768006137146	1.0	0.9477588464530826	2	Q13501	1
+Exoribonuclease, phosphorolytic domain 1 [IPR001247]	0.4699093908762747	0.574351034455126	0.5657302806960427	1.0	0.9477588464530826	7	Q96B26,Q15024	2
+Replication factor C, C-terminal [IPR013748]	0.5783325608500367	0.5724285319918289	0.5670316907400925	1.0	0.9484829219951608	3	P40937	1
+Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]	0.8067073170731789	0.5701055273890911	0.5686061264386426	1.0	0.9499276099815572	2	Q9Y4G8	1
+Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]	0.8067073170731789	0.5701055273890911	0.5686061264386426	1.0	0.9499276099815572	2	Q9Y4G8	1
+Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]	0.4941946088740072	0.5589292775517323	0.5762099873205919	1.0	0.9548724712386498	5	Q9NVN8,P36915,Q13823	3
+Zinc finger, RanBP2-type [IPR001876]	0.4558043559292365	0.5448621148649131	0.5858483541444217	1.0	0.9563425365047512	9	Q01844,O95218,P98175	3
+Ras GTPase-activating domain [IPR001936]	0.5078592874847765	0.5403586792144106	0.5889496982904072	1.0	0.9563425365047512	4	Q9UJF2,Q14C86	2
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.4885082349821387	0.5385189648879627	0.5902188157284296	1.0	0.9563425365047512	5	P20020,P16615	2
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.4885082349821387	0.5385189648879627	0.5902188157284296	1.0	0.9563425365047512	5	P20020,P16615	2
+FERM domain [IPR000299]	0.4626512797163057	0.5363294679761331	0.5917308680901272	1.0	0.9573396239807972	6	P26038,O43491	2
+Domain of unknown function DUF5600 [IPR040990]	0.7942073170731823	0.5348679906310649	0.5927411439162811	1.0	0.9573396239807972	2	Q9H223	1
+EH domain-containing protein, N-terminal [IPR031692]	0.7942073170731823	0.5348679906310649	0.5927411439162811	1.0	0.9573396239807972	2	Q9H223	1
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.5651773919319552	0.5304076036848598	0.5958293552397913	1.0	0.9596783926705202	3	Q32P28	1
+THUMP domain [IPR004114]	0.7911585365853657	0.5264039012626675	0.5986076056615088	1.0	0.9627425571198636	2	Q9NXG2	1
+Glutamine amidotransferase type 2 domain [IPR017932]	0.5623665751753647	0.5215742032166613	0.6019668284296631	1.0	0.963892400860164	3	Q06203,P08243	2
+HECT domain [IPR000569]	0.4518507101410794	0.5158162566179774	0.6059827473165567	1.0	0.9640195456085008	8	Q5T447	1
+Ion transporter-like, CBS domain [IPR044751]	0.785670731707317	0.5113026150661197	0.6091391741611514	1.0	0.9640195456085008	2	Q8NE01	1
+CNNM, transmembrane domain [IPR002550]	0.785670731707317	0.5113026150661197	0.6091391741611514	1.0	0.9640195456085008	2	Q8NE01	1
+Jumonji, helical domain [IPR041070]	0.7838414634146339	0.5063078925709784	0.6126405232138508	1.0	0.9653414031880728	2	Q9Y2K7	1
+Acyltransferase, C-terminal domain [IPR032098]	0.5557450322494382	0.5009785576842751	0.6163862136371703	1.0	0.9665595222970929	3	Q6UWP7	1
+Translation initiation factor IF2/IF5 domain [IPR002735]	0.7814024390244237	0.4996791638877483	0.6173010061105269	1.0	0.9665595222970929	2	P55010	1
+Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]	0.5487621133727121	0.4795967250154402	0.6315141755301941	1.0	0.9754955380915546	3	O60256	1
+TRASH domain [IPR011017]	0.4715602554859945	0.4790825466551849	0.6318799056212736	1.0	0.9754955380915546	5	Q9UHA3,Q9UBW7	2
+CTP synthase GATase domain [IPR033828]	0.7701219512195121	0.4694934200576919	0.6387169870083267	1.0	0.97690032593057	2	P17812	1
+CTP synthase, N-terminal [IPR017456]	0.7701219512195121	0.4694934200576919	0.6387169870083267	1.0	0.97690032593057	2	P17812	1
+Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]	0.4407280531100982	0.4633665067497335	0.6431016819403306	1.0	0.9772659441878928	7	P42356,P78527,Q9BTU6,O00443	4
+Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]	0.7643292682927181	0.4543045551732403	0.6496096379278389	1.0	0.9826862264748802	2	O95782	1
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.4364462722610685	0.4402179066806477	0.6597792916678091	1.0	0.9885594431771604	6	P16615,P20020	2
+Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]	0.746646341463444	0.40932369792413	0.6823021266942721	1.0	0.9950450406655794	2	Q9NVE7	1
+ABC transporter-like, ATP-binding domain [IPR003439]	0.4199313491299504	0.4064676518488198	0.6843990204807078	1.0	0.9950450406655794	9	P08183,P61221	2
+Tubulin binding cofactor C-like domain [IPR012945]	0.7402439024390406	0.3935759668578101	0.693894127695069	1.0	0.9950450406655794	2	O75695	1
+Zinc finger, LIM-type [IPR001781]	0.4118718164560032	0.3881887680431191	0.6978763445369465	1.0	0.9950450406655794	10	Q16527,Q9NR12,Q13642,Q14847	4
+SUN domain [IPR012919]	0.5141811527904946	0.3794099586784075	0.7043834564832787	1.0	0.9950450406655794	3	Q9UH99,O94901	2
+Isochorismatase-like [IPR000868]	0.7329268292683147	0.3759450904785156	0.7069577178795456	1.0	0.9950450406655794	2	Q96AB3	1
+Sec63 domain [IPR004179]	0.5035071668191659	0.3506165286718009	0.7258760547301952	1.0	0.9950450406655794	3	Q9UGP8,Q8N3C0	2
+Metaxin, glutathione S-transferase domain [IPR033468]	0.5028972247636572	0.3490041983025648	0.7270861577228374	1.0	0.9950450406655794	3	Q13505,Q5HYI7	2
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.5028972247636572	0.3490041983025648	0.7270861577228374	1.0	0.9950450406655794	3	Q13505,Q5HYI7	2
+Nucleoplasmin core domain [IPR024057]	0.7207317073170842	0.3474593156899929	0.7282462781430112	1.0	0.9950450406655794	2	P06748	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.7192073170731705	0.3439797003537939	0.7308615523888737	1.0	0.9950450406655794	2	O60506	1
+Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]	0.4017017217611527	0.3413170599189746	0.7328649062478008	1.0	0.9950450406655794	9	P60510,Q9BRF8	2
+Dual specificity protein phosphatase domain [IPR020422]	0.4442066761898156	0.3381717235387943	0.7352337832365337	1.0	0.9950450406655794	4	Q8WUK0,P51452	2
+Dual specificity phosphatase, catalytic domain [IPR000340]	0.4442066761898156	0.3381717235387943	0.7352337832365337	1.0	0.9950450406655794	4	Q8WUK0,P51452	2
+CRAL-TRIO lipid binding domain [IPR001251]	0.7109756097560975	0.3255092821255535	0.7447956586943976	1.0	0.9950450406655794	2	P21359	1
+Peptidase M20, dimerisation domain [IPR011650]	0.7073170731707317	0.3174758313369007	0.7508825754702189	1.0	0.9950450406655794	2	Q96KP4	1
+PIK-related kinase, FAT [IPR003151]	0.4828113019823298	0.2980063971324932	0.7656982811323916	1.0	0.9950450406655794	3	P78527	1
+FATC domain [IPR003152]	0.4828113019823298	0.2980063971324932	0.7656982811323916	1.0	0.9950450406655794	3	P78527	1
+PIK-related kinase [IPR014009]	0.4828113019823298	0.2980063971324932	0.7656982811323916	1.0	0.9950450406655794	3	P78527	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.4794675262281713	0.289926280665445	0.7718726356442616	1.0	0.9950450406655794	3	Q9BUJ2	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]	0.6929878048780487	0.2870801632737502	0.7740509405979257	1.0	0.9950450406655794	2	Q96G03	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]	0.6929878048780487	0.2870801632737502	0.7740509405979257	1.0	0.9950450406655794	2	Q96G03	1
+DNA ligase, ATP-dependent, central [IPR012310]	0.6899390243902437	0.2808369990662492	0.7788354239885953	1.0	0.9950450406655794	2	P18858	1
+DNA ligase, ATP-dependent, N-terminal [IPR012308]	0.6899390243902437	0.2808369990662492	0.7788354239885953	1.0	0.9950450406655794	2	P18858	1
+DNA ligase, ATP-dependent, C-terminal [IPR012309]	0.6899390243902437	0.2808369990662492	0.7788354239885953	1.0	0.9950450406655794	2	P18858	1
+C-CAP/cofactor C-like domain [IPR017901]	0.4639853983138648	0.254118647568325	0.7994038974591566	1.0	0.9950450406655794	3	O75695	1
+CARP motif [IPR006599]	0.4639853983138648	0.254118647568325	0.7994038974591566	1.0	0.9950450406655794	3	O75695	1
+F-box domain [IPR001810]	0.3660571406701818	0.2195168838521786	0.8262474291726796	1.0	0.9950450406655794	7	Q8NEZ5,Q9Y2K7,Q8TB52	3
+Phosphofructokinase domain [IPR000023]	0.4455626715462107	0.2150894650562897	0.8296975673581986	1.0	0.9950450406655794	3	P08237,Q01813	2
+DNA mismatch repair protein MutS, connector domain [IPR007860]	0.4420525024952467	0.2081092087433553	0.8351436970360893	1.0	0.9950450406655794	3	P20585	1
+DNA mismatch repair protein MutS, core [IPR007696]	0.4420525024952467	0.2081092087433553	0.8351436970360893	1.0	0.9950450406655794	3	P20585	1
+DNA mismatch repair protein MutS-like, N-terminal [IPR007695]	0.4420525024952467	0.2081092087433553	0.8351436970360893	1.0	0.9950450406655794	3	P20585	1
+DNA mismatch repair protein MutS, C-terminal [IPR000432]	0.4420525024952467	0.2081092087433553	0.8351436970360893	1.0	0.9950450406655794	3	P20585	1
+Chromo domain [IPR023780]	0.3555590919047294	0.1934054850530658	0.8466414200841421	1.0	0.9950450406655794	8	P83916	1
+STAT transcription factor, protein interaction [IPR013799]	0.6408536585365853	0.1916646113336324	0.8480049280672775	1.0	0.9950450406655794	2	P40763	1
+STAT transcription factor, DNA-binding [IPR013801]	0.6408536585365853	0.1916646113336324	0.8480049280672775	1.0	0.9950450406655794	2	P40763	1
+STAT transcription factor, all-alpha domain [IPR013800]	0.6408536585365853	0.1916646113336324	0.8480049280672775	1.0	0.9950450406655794	2	P40763	1
+Glycogen synthase kinase 3, catalytic domain [IPR039192]	0.640548780487818	0.1911792106806884	0.8483851906808393	1.0	0.9950450406655794	2	P49841	1
+ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]	0.6393292682926827	0.1892461893839024	0.8498998677783913	1.0	0.9950450406655794	2	Q14240	1
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.4275693809088159	0.1808891873561118	0.8564545560880592	1.0	0.9950450406655794	3	O60884,P31689	2
+Coatomer subunit gamma, C-terminal [IPR032154]	0.6301829268292907	0.1751865649092633	0.8609330407319329	1.0	0.9950450406655794	2	Q9Y678	1
+Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]	0.6301829268292907	0.1751865649092633	0.8609330407319329	1.0	0.9950450406655794	2	Q9Y678	1
+Endonuclease/exonuclease/phosphatase [IPR005135]	0.3767541183648631	0.1730648609033277	0.8626004450650875	1.0	0.9950450406655794	4	Q6L8Q7,P27695,Q01968	3
+Ribosomal L28e/Mak16 [IPR029004]	0.6280487804878047	0.1720172601048251	0.86342395965718	1.0	0.9950450406655794	2	P46779	1
+RING-type zinc-finger, LisH dimerisation motif [IPR027370]	0.4196354313798959	0.1670687130716799	0.8673159833389339	1.0	0.9950450406655794	3	O15344	1
+RNA 3'-terminal phosphate cyclase domain [IPR023797]	0.6192073170731782	0.1593353811187871	0.8734046467158119	1.0	0.9950450406655794	2	Q9Y2P8	1
+RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]	0.6192073170731782	0.1593353811187871	0.8734046467158119	1.0	0.9950450406655794	2	Q9Y2P8	1
+Phox homology [IPR001683]	0.3350350268352911	0.1502901765355246	0.8805356829539148	1.0	0.9950450406655794	11	Q96L92,O60749,Q9UNH7,O00443,Q15036	5
+Ribosomal protein L30, N-terminal [IPR012988]	0.6121951219512192	0.1497892448635618	0.880930894977008	1.0	0.9950450406655794	2	Q6DKI1	1
+Ribosomal protein L7, eukaryotic/archaeal [IPR035808]	0.6121951219512192	0.1497892448635618	0.880930894977008	1.0	0.9950450406655794	2	Q6DKI1	1
+14-3-3 domain [IPR023410]	0.33791208791209	0.1481169500898437	0.8822504727546228	1.0	0.9950450406655794	6	P63104,P62258,P27348,P31946,Q04917	5
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.336945732213205	0.1457019409865343	0.8841566890375614	1.0	0.9950450406655794	7	Q15375,P07948	2
+Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]	0.6085365853658663	0.1449875688802613	0.8847206866743944	1.0	0.9950450406655794	2	Q9H1B7	1
+GINS subunit, domain A [IPR021151]	0.6048780487804875	0.1403079863357673	0.8884166545619632	1.0	0.9950450406655794	2	Q9Y248	1
+Domain of unknown function DUF1747 [IPR013719]	0.6036585365853655	0.1387751642677187	0.88962782010065	1.0	0.9950450406655794	2	Q08945	1
+GTP binding protein, second domain [IPR031662]	0.6027439024390348	0.1376343971036672	0.890529369266919	1.0	0.9950450406655794	2	P55039	1
+CCAAT-binding factor [IPR005612]	0.3955474229948184	0.1298738015045171	0.8966662720795218	1.0	0.9950450406655794	3	Q03701,Q9BVI4	2
+Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]	0.3903884223236152	0.1228349785895484	0.9022377750831438	1.0	0.9950450406655794	3	O00443	1
+3'-5' exonuclease domain [IPR002562]	0.5893292682926827	0.1217675340342338	0.9030831266589594	1.0	0.9950450406655794	2	Q9NVH0	1
+LEM domain [IPR003887]	0.3377738041244202	0.1193713896763438	0.9049811269281428	1.0	0.9950450406655794	5	Q8NC56	1
+DNA2/NAM7 helicase-like, C-terminal [IPR041679]	0.3368892083822685	0.1178171666131508	0.9062125272928512	1.0	0.9950450406655794	5	P51530,Q9HCE1	2
+SUN coiled coil domain 2 [IPR040994]	0.5774390243902436	0.1090341296372181	0.9131754201648244	1.0	0.9950450406655794	2	O94901	1
+Peptidase M41 [IPR000642]	0.5765243902439021	0.1081053932147003	0.9139120900627244	1.0	0.9950450406655794	2	Q96TA2	1
+MIF4G-like, type 3 [IPR003890]	0.3143454005086916	0.098236190819692	0.9217447453146644	1.0	0.9951042897261712	7	A9UHW6	1
+Class II aldolase/adducin N-terminal [IPR001303]	0.3641354071363253	0.0919391030140115	0.926746423300168	1.0	0.9957505305656676	3	Q9UEY8,P35611	2
+RNA polymerase Rpb2, domain 7 [IPR007641]	0.5573170731707313	0.0902256797332783	0.928107878071626	1.0	0.9957505305656676	2	Q9H9Y6	1
+RNA polymerase Rpb2, domain 2 [IPR007642]	0.5573170731707313	0.0902256797332783	0.928107878071626	1.0	0.9957505305656676	2	Q9H9Y6	1
+RNA polymerase Rpb2, domain 3 [IPR007645]	0.5573170731707313	0.0902256797332783	0.928107878071626	1.0	0.9957505305656676	2	Q9H9Y6	1
+DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]	0.5573170731707313	0.0902256797332783	0.928107878071626	1.0	0.9957505305656676	2	Q9H9Y6	1
+RNA polymerase, beta subunit, protrusion [IPR007644]	0.5573170731707313	0.0902256797332783	0.928107878071626	1.0	0.9957505305656676	2	Q9H9Y6	1
+Cullin homology domain [IPR016158]	0.3099134243384076	0.0899715730485478	0.9283098046102154	1.0	0.9957505305656676	7	Q13618,Q13619,Q13617	3
+Cullin, N-terminal [IPR001373]	0.3099134243384076	0.0899715730485478	0.9283098046102154	1.0	0.9957505305656676	7	Q13618,Q13619,Q13617	3
+Dynamin, N-terminal [IPR045063]	0.3037400156211056	0.0790322079038515	0.9370070049743378	1.0	0.9978564638631096	7	Q9H223,Q9H4M9	2
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.3037400156211056	0.0790322079038515	0.9370070049743378	1.0	0.9978564638631096	7	Q9H223,Q9H4M9	2
+Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]	0.3012820512820536	0.076907130612981	0.9386974249418694	1.0	0.998860755123255	6	P62140,O00743,P53041,Q08209,P60510	5
+GPAT/DHAPAT, acyltransferase domain [IPR041728]	0.5350609756097557	0.0731895317211542	0.941655296523528	1.0	1.0	2	Q9HCL2	1
+Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]	0.5350609756097557	0.0731895317211542	0.941655296523528	1.0	1.0	2	Q9HCL2	1
+Pleckstrin homology domain [IPR001849]	0.2570637265343579	0.0678646484870209	0.945893380268198	1.0	1.0	27	Q96JJ3,O14578,Q9UJF2,Q96P47,P19174,Q13464	6
+Pseudouridine synthase, RsuA/RluA-like [IPR006145]	0.5213414634146338	0.0644997119661175	0.948572336453482	1.0	1.0	2	Q8IZ73	1
+Immunoglobulin I-set [IPR013098]	0.3226471342466129	0.0585375266907249	0.9533204717526136	1.0	1.0	3	Q13308	1
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.3213604063168047	0.0577696971577188	0.9539320760178088	1.0	1.0	3	Q9BYT8	1
+Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]	0.2925886413338963	0.0572854690546823	0.9543177953588176	1.0	1.0	10	Q9Y678,O95782	2
+AMP-dependent synthetase/ligase [IPR000873]	0.291386682956626	0.0572395640741755	0.9543543622335384	1.0	1.0	8	O60488,O14975,P33121,Q86V21,Q4G176,O95573,Q6P1M0	7
+AMP-binding enzyme, C-terminal domain [IPR025110]	0.291119926762268	0.0535638134736794	0.9572826877670648	1.0	1.0	5	Q4G176,O14975,P33121,Q6P1M0	4
+GHMP kinase, C-terminal domain [IPR013750]	0.4966463414634142	0.0519582967322311	0.9585619228883652	1.0	1.0	2	Q03426	1
+Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]	0.4908536585365851	0.0495379491992468	0.96049059522252	1.0	1.0	2	O75694	1
+MIT domain [IPR007330]	0.4899390243902435	0.0491724904215001	0.9607818342011614	1.0	1.0	2	Q9UN37	1
+Nucleoside phosphorylase domain [IPR000845]	0.4749999999999996	0.0438100985798401	0.9650557773117984	1.0	1.0	2	Q13126	1
+Coatomer, WD associated region [IPR006692]	0.4707317073170728	0.0424758143149885	0.9661193917262992	1.0	1.0	2	P53621	1
+LRRC8, pannexin-like TM region [IPR021040]	0.4615853658536583	0.0398871624354367	0.9681830858515292	1.0	1.0	2	Q8IWT6	1
+MCM N-terminal domain [IPR027925]	0.2747252747252771	0.0393463844041831	0.968614225820788	1.0	1.0	6	P33992,P25205,Q14566,P49736,P33993	5
+MCM OB domain [IPR033762]	0.2747252747252771	0.0393463844041831	0.968614225820788	1.0	1.0	6	P33992,P25205,Q14566,P49736,P33993	5
+MCM, AAA-lid domain [IPR041562]	0.2747252747252771	0.0393463844041831	0.968614225820788	1.0	1.0	6	P33992,P25205,Q14566,P49736,P33993	5
+MCM domain [IPR001208]	0.2747252747252771	0.0393463844041831	0.968614225820788	1.0	1.0	6	P33992,P25205,Q14566,P49736,P33993	5
+Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]	0.4435975609756094	0.0357625590332313	0.971471687520242	1.0	1.0	2	P47897	1
+Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]	0.4426829268292678	0.0355836814308508	0.9716143204131078	1.0	1.0	2	P46926	1
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.4356707317073166	0.0343017645611732	0.9726365177828078	1.0	1.0	2	Q9Y305	1
+HRDC domain [IPR002121]	0.4344512195121947	0.0340943842725685	0.9728018865846332	1.0	1.0	2	Q01780	1
+CELF1/2, RNA recognition motif 3 [IPR034199]	0.4277439024390239	0.0330311514832223	0.973649745897829	1.0	1.0	2	O95319	1
+CELF1/2, RNA recognition motif 2 [IPR034198]	0.4277439024390239	0.0330311514832223	0.973649745897829	1.0	1.0	2	O95319	1
+CELF1/2, RNA recognition motif 1 [IPR034196]	0.4277439024390239	0.0330311514832223	0.973649745897829	1.0	1.0	2	O95319	1
+Serine/threonine-protein kinase N, C2 domain [IPR037784]	0.4259146341463409	0.0327629530143479	0.973863621553584	1.0	1.0	2	Q16513	1
+Serine/threonine-protein kinase N, first HR1 domain [IPR037313]	0.4259146341463409	0.0327629530143479	0.973863621553584	1.0	1.0	2	Q16513	1
+HDGF-related, PWWP domain [IPR035496]	0.2336078072583086	0.0315337486156372	0.9748438780172042	1.0	1.0	3	P51858,Q7Z4V5	2
+ELM2 domain [IPR000949]	0.4124999999999994	0.0310544559966804	0.9752261109841338	1.0	1.0	2	O94776	1
+Metastasis-associated protein MTA1, R1 domain [IPR035170]	0.4124999999999994	0.0310544559966804	0.9752261109841338	1.0	1.0	2	O94776	1
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.4054878048780482	0.0303242138474283	0.9758084855926754	1.0	1.0	2	P13674	1
+MATH/TRAF domain [IPR002083]	0.4048780487804873	0.0302654680178503	0.9758553364788248	1.0	1.0	2	Q93009	1
+NAD-dependent epimerase/dehydratase [IPR001509]	0.3908536585365849	0.0291019314840189	0.9767832953502054	1.0	1.0	2	Q13630	1
+Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]	0.3804878048780482	0.0284437083257338	0.9773082640870197	1.0	1.0	2	Q13557	1
+Amidohydrolase-related [IPR006680]	0.2428309945088544	0.0270881224600751	0.9783894481896728	1.0	1.0	4	Q14195,P27708,Q9BPU6	3
+Polyamine biosynthesis  domain [IPR030374]	0.3335365853658531	0.0268805695697751	0.97855499115466	1.0	1.0	2	P19623	1
+Spermidine synthase, tetramerisation domain [IPR035246]	0.3335365853658531	0.0268805695697751	0.97855499115466	1.0	1.0	2	P19623	1
+Septin-type guanine nucleotide-binding (G) domain [IPR030379]	0.2601292864839283	0.0267226761648621	0.9786809266250148	1.0	1.0	5	Q15019	1
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.3057926829268287	0.0265694485164198	0.9788031412052248	1.0	1.0	2	O15254	1
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.3018292682926824	0.0265436226828249	0.978823739974202	1.0	1.0	2	P52701	1
+Cobalamin (vitamin B12)-binding domain [IPR006158]	0.2862804878048776	0.0264707973237162	0.978881825793789	1.0	1.0	2	Q99707	1
+Proteasome component (PCI) domain [IPR000717]	0.2673295145349449	0.0257180619460791	0.9794822172719456	1.0	1.0	17	Q9UBQ5,O43242,Q9UNS2,P60228,P61201,Q14152,Q13098,Q9BT78,Q7L2H7,O00231,Q9UNM6	11
+Kinesin-like [IPR022164]	0.2324588163514415	0.0238370794285791	0.9809825633377548	1.0	1.0	4	Q5R372,Q9Y3P9,Q12756	3
+Band 4.1 domain [IPR019749]	0.2496318811232646	0.0105182955148621	0.9916077691481155	1.0	1.0	7	P26038,O43491	2
+FERM central domain [IPR019748]	0.2496318811232646	0.0105182955148621	0.9916077691481155	1.0	1.0	7	P26038,O43491	2
+Thioredoxin domain [IPR013766]	0.2339443705933279	0.0062021512494619	0.9950514310001471	1.0	1.0	25	Q6DKJ4,Q8IXB1,Q9H3N1,Q9Y320,Q96JJ7,Q6ZRP7	6