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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:416bccc4195d38dfb72005f24425f30599d9ab261571a650a43df293eb2921e6
+size 72284

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 55,
+    "title": "Average number of proteins per term",
+    "value": 2.8181818181818183
+}

interpro_active_site/paths.json

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+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C042/C042_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.9001473176087759	1.8122295345095831	0.0699507373274808	0.981472048573402	0.7005696428342499	3	Q9HB40	1
+Histidine acid phosphatase active site [IPR033379]	0.846341463414656	0.8485985216078678	0.3961047298983806	0.9999999999991028	0.8778717137223085	2	Q9NPH0	1
+Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]	0.3079268292682922	0.021627981203137	0.98274471297687	1.0	1.0	2	P18669	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "BUB1", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPN5", "CASP3", "CASP6", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CHEK2", "CIT", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK2A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAPK1", "MARK1", "MARK2", "MASTL", "MDH1", "MDH2", "MTM1", "MTMR2", "NCEH1", "NEK4", "NEK9", "NME1", "NME2", "NME3", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKACA", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1", "VRK2", "YES1"], "leading_proteins": ["ACP6", "PGAM1", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

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+{}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:01353b41f44333c3fc0f67b5e49709448843a6070c8295d0951b8dfa75a57c3c
+size 73313

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 30,
+    "title": "Average number of proteins per term",
+    "value": 4.866666666666666
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C042/C042_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,2 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+IQ motif, EF-hand binding site [IPR000048]	0.5783744056566347	1.0444966776372475	0.2962556555326068	0.9999735486688855	0.8853144821033553	9	Q15386,P35580,P46940	3

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Aryldialkylphosphatase, zinc-binding site [IPR017947]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "AURKA", "BPNT1", "BUB1", "CALM3", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CIT", "COX2", "COX5B", "CSK", "CSNK2A1", "CSNK2A2", "CYB5B", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "HPCAL4", "IDE", "ILKAP", "IMPA1", "INPP1", "IQGAP1", "LETM1", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK14", "MARK1", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NEK4", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXSR1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1G", "PRKAA1", "PRKACA", "PRKCSH", "PSAT1", "PTER", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK24", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB6", "UBE3C", "UQCRC2", "VRK1", "YES1"], "leading_proteins": ["IQGAP1", "MYH10", "UBE3C"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "ABC transporter-like, conserved site [IPR017871]", "1": "DnaJ domain, conserved site [IPR018253]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:702366c27a50d73959d1e44be6bf4e25ceaa282a4d137a2bfa16443e1412b39d
+size 76717

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	4	8	2.293033262485352	0.0218460900321697	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	0.0078220093798615	0.0009934566258862	1.5472815952013036e-06	1.7923085924657402e-06	5.489393781591606e-05
+FERM conserved site [IPR019747]	3	6	1.9605359120063508	0.0499331847777611	4.325242718446602	8.264563106796116	-0.4659609220802079	0.4770555224881084	2.1477112878688356	1.3312548111579257	0.9014747004592728	0.3040408090630811	1.0	1.0	1.0	1.0	0.0705348016344186

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 287,
+    "title": "Average number of proteins per term",
+    "value": 2.662020905923345
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C042/C042_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,37 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.8520869739424277	2.293033262485352	0.0218460900321697	0.9982345108935904	0.647763801843889	8	P49721,P28072,P28070,P28074	4
+FERM conserved site [IPR019747]	0.7649130322202009	1.9605359120063508	0.0499331847777611	0.9999995874840516	0.647763801843889	6	P26038,P35241,P15311	3
+Ubiquitin interacting motif [IPR003903]	0.7898214555329266	1.7562022342063026	0.0790538833598111	0.9999999999456473	0.647763801843889	4	O14964	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.6768137970608177	1.5667040743641212	0.1171838780064637	0.9999999999999996	0.6726354597571021	6	Q9P2W9,O60499,Q13190	3
+Mini-chromosome maintenance, conserved site [IPR018525]	0.6700856237990857	1.53614125764044	0.1245037393575798	1.0	0.6823785916162401	6	P25205,P49736,P33992,P33991	4
+Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]	0.6687889594574346	1.3869478231795842	0.1654576736421762	1.0	0.7087515273926056	5	P78527,P42345	2
+Haem oxygenase conserved site [IPR018207]	0.9911585365853676	1.3510573712239806	0.176677055466417	1.0	0.7236790098932508	2	P09601	1
+Ras GTPase-activating protein, conserved site [IPR023152]	0.7633424824641636	1.288157515356621	0.1976911375315984	1.0	0.7411247577262432	3	Q9UJF2,P46940	2
+Cullin, conserved site [IPR016157]	0.6017027792473436	1.2232220035993329	0.2212458569862048	1.0	0.7937195119380098	6	Q13619,Q93034,Q13618,Q13617	4
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.901829268292683	1.0375385628744802	0.2994849334060041	1.0	0.8953351654950331	2	P04066	1
+Sterol reductase, conserved site [IPR018083]	0.8862804878048953	0.9839450948285148	0.3251425096169384	1.0	0.897268271731359	2	Q14739	1
+Cadherin conserved site [IPR020894]	0.6678865507776712	0.923389168858593	0.3558044341087152	1.0	0.9368428677908374	3	P19022,Q02487	2
+AMP-binding, conserved site [IPR020845]	0.5435997414889194	0.9096796691619792	0.3629914692284504	1.0	0.9418685600812836	8	Q4G176	1
+ABC transporter-like, conserved site [IPR017871]	0.5377865102061798	0.8608991021723876	0.3892936162042426	1.0	0.9459116550307228	9	Q9NUQ8,P08183,P28288,O75027,P61221	5
+Ribosomal protein L30, conserved site [IPR018038]	0.8030487804878046	0.7070679086975081	0.4795242776162016	1.0	1.0	2	Q6DKI1	1
+Heat shock protein Hsp90, conserved site [IPR019805]	0.6033740784984313	0.6874943970366906	0.4917712303376458	1.0	1.0	3	P07900	1
+Guanylate kinase, conserved site [IPR020590]	0.4829751419499362	0.6656328077211396	0.5056458310157523	1.0	1.0	7	Q8N3R9,Q14168	2
+Dynamin, GTPase region, conserved site [IPR019762]	0.7814024390243901	0.6390026202253544	0.5228212273286588	1.0	1.0	2	P50570	1
+Sugar transporter, conserved site [IPR005829]	0.7789634146341461	0.6314665044382233	0.5277355437457385	1.0	1.0	2	Q7L0J3	1
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.7643292682927173	0.5868698224330305	0.5572911387525474	1.0	1.0	2	P11216	1
+Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]	0.5622162534437524	0.5465897550055686	0.5846606091357258	1.0	1.0	3	Q14155	1
+Chromo domain, conserved site [IPR023779]	0.4144428492985925	0.4111618163029913	0.6809538848601169	1.0	1.0	6	P83916	1
+DNA ligase, ATP-dependent, conserved site [IPR016059]	0.6975609756097838	0.3995523089153845	0.6894862888117426	1.0	1.0	2	P18858	1
+Ribosomal protein L24/L26, conserved site [IPR005825]	0.69390243902439	0.390185177322028	0.6963996215083497	1.0	1.0	2	P61254	1
+Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]	0.4411794693982633	0.3795085237992454	0.704310275803834	1.0	1.0	4	P48735	1
+Polyprenyl synthetase, conserved site [IPR033749]	0.6850609756097559	0.3679844848293188	0.7128848030590289	1.0	1.0	2	P14324	1
+Short-chain dehydrogenase/reductase, conserved site [IPR020904]	0.4228940306076893	0.3217848930286754	0.747615659720537	1.0	1.0	13	Q53GQ0,Q06136,Q6IAN0,P51659	4
+Intermediate filament protein, conserved site [IPR018039]	0.386779944194955	0.2659014565683927	0.7903151032884996	1.0	1.0	5	P08670,P07197	2
+DnaJ domain, conserved site [IPR018253]	0.3826071825691706	0.237753089772746	0.8120726043577462	1.0	1.0	10	Q8WXX5,Q9NVH1,Q96KC8,Q99543,Q96EY1,Q5F1R6	6
+EGF-like, conserved site [IPR013032]	0.6262195121951369	0.2374576102544477	0.8123018009267233	1.0	1.0	2	O94813	1
+GTP1/OBG, conserved site [IPR006074]	0.6131097560975607	0.2127920204416597	0.8314891879789126	1.0	1.0	2	P55039	1
+Alpha-D-phosphohexomutase, conserved site [IPR016066]	0.4318389752973508	0.193712284929773	0.846401172068028	1.0	1.0	3	Q96G03,P36871	2
+Ribosomal protein S5, N-terminal, conserved site [IPR018192]	0.567682926829268	0.1405795626167636	0.8882020945492743	1.0	1.0	2	P15880	1
+Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]	0.5603658536585363	0.1308791405303987	0.8958709161721894	1.0	1.0	2	Q16539	1
+Malic enzyme, conserved site [IPR015884]	0.5390243902439021	0.1055743326905596	0.9159200904601028	1.0	1.0	2	P23368	1
+RNA polymerase, beta subunit, conserved site [IPR007121]	0.2905487804878044	0.0213741926338176	0.9829471601567508	1.0	1.0	2	P30876	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Arrestin, conserved site [IPR017864]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "FeS cluster insertion, C-terminal, conserved site [IPR017870]", "Fibrillarin, conserved site [IPR020813]", "Folylpolyglutamate synthetase, conserved site [IPR018109]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamine synthetase, N-terminal conserved site [IPR027302]", "Glutamine synthetase, glycine-rich site [IPR027303]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycerate/sugar phosphate transporter, conserved site [IPR021159]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "GoLoco motif [IPR003109]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MnmG-related, conserved site [IPR020595]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Pseudouridine synthase, RluC/RluD, conserved site [IPR006224]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "Ribosome-binding factor A, conserved site [IPR020053]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AACS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABR", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APLP2", "APP", "ARHGEF7", "ARIH2", "ARRB2", "ARSA", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BDH2", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CIAO1", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DMD", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC2", "DSG2", "DST", "DTX3L", "DTYMK", "DUS1L", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPHA7", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FPGS", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GLUL", "GMPPA", "GMPPB", "GNB1", "GNB2", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPSM1", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HOXA10", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B8", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPA1", "IMPDH1", "IMPDH2", "ING5", "INPP1", "IQGAP1", "ISCA2", "IVD", "KDM2A", "KDM5C", "KDSR", "KIF11", "KIF1A", "KIF1B", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTO1", "MTOR", "MVK", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFM", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NOTCH2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PDSS1", "PEBP1", "PEPD", "PEX1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF2", "PHF3", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RASAL2", "RBFA", "RCL1", "RDH13", "RDX", "RIDA", "RIOK2", "RNF14", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RPUSD2", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLC37A4", "SLC5A6", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STMN1", "STRN", "STX10", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB6", "TUBG1", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP22", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF3", "ACSF3", "ARHGEF7", "CBX1", "CDH2", "CUL2", "CUL3", "CUL4A", "CUL5", "DHRS7B", "DNAJA3", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC21", "DNAJC9", "DNM2", "DRG2", "DSC2", "EZR", "FDPS", "FUCA1", "HGS", "HMOX1", "HSD17B12", "HSD17B4", "HSP90AA1", "IDH2", "IQGAP1", "KDSR", "LBR", "LIG1", "MAPK14", "MCM2", "MCM3", "MCM4", "MCM5", "ME2", "MPP2", "MPP5", "MSN", "MTOR", "NEFM", "PGM1", "PGM2", "POLR2B", "PRKDC", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PYGB", "RASAL2", "RDX", "RPL26", "RPL7L1", "RPS2", "SLIT2", "STX10", "STX18", "STX5", "SV2A", "VIM"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Cytochrome b5-like heme/steroid binding domain [IPR001199]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "1": "Cullin, N-terminal [IPR001373]", "2": "Cullin homology domain [IPR016158]", "3": "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "4": "ABC transporter-like, ATP-binding domain [IPR003439]", "5": "Proteasome component (PCI) domain [IPR000717]", "6": "MPN domain [IPR037518]", "7": "Ubiquitin-associated domain [IPR015940]", "8": "SNF2, N-terminal [IPR000330]", "9": "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "10": "Importin-beta, N-terminal domain [IPR001494]", "11": "DnaJ domain [IPR001623]", "12": "WW domain [IPR001202]", "13": "F-box domain [IPR001810]", "14": "BRCT domain [IPR001357]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:65c651ea1bd7ecef0a453239505138ab1fe7d8c274b24b6dcebda49148c0f665
+size 115587

interpro_domain/df_merge.tsv

@@ -0,0 +1,6 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	5	7	2.182999353269813	0.0290358576407974	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	1.0	0.0014481500629001	0.0055563644779973	0.0001405335592956	0.0001590313802548
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	2	5	2.122716814250834	0.0337775891609322	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	1.0	0.0378187125466048	0.073646168181401	0.0007102815399137	0.0053334351931861
+Aminopeptidase N-like , N-terminal domain [IPR045357]	2	5	2.122716814250834	0.0337775891609322	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	1.0	0.0378187125466048	0.073646168181401	0.0007102815399137	0.0053334351931861
+Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]	3	6	2.030106844573617	0.0423456799469037	2.5849514563106797	6.101941747572815	-0.1563882835180277	0.5584151228591979	1.991503005507268	2.622586012824919	0.92042626257127	0.3048786059136322	1.0	1.0	1.0	0.3229860752427858	0.4155957413240573
+FERM domain [IPR000299]	3	6	1.9605359120063508	0.0499331847777611	4.371359223300971	8.701456310679612	-0.4618762482317655	0.4958506329710698	2.2695654382999426	1.5767416985713203	0.8814412188872601	0.311730511859302	1.0	1.0	1.0	1.0	0.2151867556135544

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3282,
+    "annotations_size": 2673,
+    "title": "Average number of proteins per term",
+    "value": 2.182566404788627
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C042/C042_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,279 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.91732763880415	2.2675860706829427	0.0233544474650202	1.0	0.8510853322801095	4	Q96G23,P27544,Q15629	3
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.8213601088177307	2.1829993532698135	0.0290358576407974	1.0	0.8510853322801095	7	O43169,Q8WUJ1,Q9UMX5,O15173,O00264	5
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8410226108644627	2.122716814250834	0.0337775891609322	1.0	0.8510853322801095	5	Q9UIQ6,P55786	2
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8410226108644627	2.122716814250834	0.0337775891609322	1.0	0.8510853322801095	5	Q9UIQ6,P55786	2
+Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]	0.780802331223807	2.0301068445736172	0.0423456799469037	1.0	0.8510853322801095	6	P52429,O14578,Q13464	3
+ERAP1-like C-terminal domain [IPR024571]	0.9490698383653544	1.995778422245848	0.0459580465112157	1.0	0.8510853322801095	3	Q9UIQ6,P55786	2
+Homeobox domain [IPR001356]	0.8473373625719169	1.9898405121847356	0.0466085071162609	1.0	0.8510853322801095	4	Q96G23	1
+FERM domain [IPR000299]	0.7649130322202009	1.9605359120063508	0.0499331847777611	1.0	0.8510853322801095	6	P26038,P35241,P15311	3
+FERM, N-terminal [IPR018979]	0.7955826617004376	1.9327963440841505	0.0532612909000911	1.0	0.8510853322801095	5	P26038,P35241,P15311	3
+FERM, C-terminal PH-like domain [IPR018980]	0.7955826617004376	1.9327963440841505	0.0532612909000911	1.0	0.8510853322801095	5	P26038,P35241,P15311	3
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.7632339554084637	1.9071917668644471	0.056495759253196	1.0	0.8510853322801095	8	Q8N4Q0,Q14914	2
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.7129467393479426	1.729768123054187	0.0836717118891532	1.0	0.8510853322801095	6	P13674,Q32P28,Q8N543	3
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.7129467393479426	1.729768123054187	0.0836717118891532	1.0	0.8510853322801095	6	P13674,Q32P28,Q8N543	3
+Major facilitator superfamily domain [IPR020846]	0.7794386821232484	1.7135701073609169	0.0866077074392177	1.0	0.8510853322801095	4	Q7L0J3,P53985,O43826	3
+W2 domain [IPR003307]	0.6967688916351915	1.6327609229150082	0.1025192886365968	1.0	0.8510853322801095	7	P55010,Q9Y6E2,Q04637	3
+ERM family, FERM domain C-lobe [IPR041789]	0.8462946020128063	1.607346210317763	0.1079784426222505	1.0	0.8510853322801095	3	P35241,P15311	2
+HR1 rho-binding domain [IPR011072]	0.7039180016334556	1.5400080862035326	0.1235583823827553	1.0	0.8568788907884749	5	Q15642	1
+MCM, AAA-lid domain [IPR041562]	0.6700856237990857	1.53614125764044	0.1245037393575798	1.0	0.8568788907884749	6	P25205,P49736,P33992,P33991	4
+MCM OB domain [IPR033762]	0.6700856237990857	1.53614125764044	0.1245037393575798	1.0	0.8568788907884749	6	P25205,P49736,P33992,P33991	4
+MCM N-terminal domain [IPR027925]	0.6700856237990857	1.53614125764044	0.1245037393575798	1.0	0.8568788907884749	6	P25205,P49736,P33992,P33991	4
+MCM domain [IPR001208]	0.6700856237990857	1.53614125764044	0.1245037393575798	1.0	0.8568788907884749	6	P25205,P49736,P33992,P33991	4
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.8167124123208173	1.4938333803597956	0.1352191744601731	1.0	0.8696963989005837	3	P13674,Q32P28	2
+Polyketide synthase, enoylreductase domain [IPR020843]	0.6739994083217136	1.4828857529116866	0.1381047673234445	1.0	0.8696963989005837	9	Q8N4Q0	1
+Glutamine amidotransferase [IPR017926]	0.7183183967972495	1.460423857541083	0.1441736198988443	1.0	0.8778498541904578	4	P17812	1
+U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]	0.7026043530287875	1.3949102361251553	0.1630429099760788	1.0	0.90593613913966	4	Q15435	1
+Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]	0.7812977912656391	1.3574057769960926	0.174652313655852	1.0	0.90593613913966	3	Q6DKI1	1
+Dynamin, GTPase domain [IPR001401]	0.7807258310460496	1.355199978379584	0.1753538515916621	1.0	0.90593613913966	3	P50570,O00429	2
+Exportin-2, central domain [IPR013713]	0.7801158889905486	1.3528476677347347	0.1761043007912177	1.0	0.90593613913966	3	P55060,O15397	2
+Arf GTPase activating protein [IPR001164]	0.6580894811744321	1.3401795433196289	0.1801869806019045	1.0	0.9069365231374528	5	Q96P47,Q8N6H7	2
+Oxidoreductase, N-terminal domain [IPR041694]	0.9835365853658536	1.3240837254915954	0.1854752399123107	1.0	0.9103267574546592	2	Q14914	1
+KOW [IPR005824]	0.6494083712520664	1.3022074157659964	0.1928454908155077	1.0	0.9103267574546592	5	P61353,Q96A35,P61254	3
+Gelsolin-like domain [IPR007123]	0.6240248973301329	1.3009207490194497	0.1932855830816988	1.0	0.9103267574546592	7	Q15436,Q13045,Q15437	3
+Peptidase M28 [IPR007484]	0.7651501520896622	1.2951283499345707	0.1952759565522217	1.0	0.9103267574546592	3	P02786	1
+Ras GTPase-activating domain [IPR001936]	0.6772422208663863	1.289033561305971	0.1973864191591772	1.0	0.9103267574546592	4	P21359,P46940,Q9UJF2	3
+AMP-binding enzyme, C-terminal domain [IPR025110]	0.6405245275440001	1.2633382117547105	0.2064676592435463	1.0	0.9103267574546592	5	Q4G176	1
+AP complex, mu/sigma subunit [IPR022775]	0.6405022472683223	1.2632407284163791	0.2065026799668081	1.0	0.9103267574546592	5	P61923	1
+Band 4.1 domain [IPR019749]	0.6152656111831947	1.260715500552517	0.2074113672434041	1.0	0.9103267574546592	7	P26038,P35241,P15311	3
+FERM central domain [IPR019748]	0.6152656111831947	1.260715500552517	0.2074113672434041	1.0	0.9103267574546592	7	P26038,P35241,P15311	3
+LEM domain [IPR003887]	0.638856607498906	1.2560406157081805	0.2091012447420928	1.0	0.9103267574546592	5	P50402,Q8NC56,Q86XL3	3
+L27 domain [IPR004172]	0.6042807301644373	1.2350577194606391	0.2168090234388109	1.0	0.91502135702069	6	Q8N3R9,Q14168	2
+L27 domain, C-terminal [IPR014775]	0.6042807301644373	1.2350577194606391	0.2168090234388109	1.0	0.91502135702069	6	Q8N3R9,Q14168	2
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.9582317073170732	1.2347256139822442	0.2169326397569349	1.0	0.91502135702069	2	O15254	1
+Sec23, C-terminal [IPR037550]	0.957926829268298	1.233651352748236	0.2173328486111638	1.0	0.91502135702069	2	Q15437	1
+Cullin protein, neddylation domain [IPR019559]	0.6017027792473436	1.2232220035993329	0.2212458569862048	1.0	0.91502135702069	6	Q13619,Q93034,Q13618,Q13617	4
+Cullin, N-terminal [IPR001373]	0.6047853072228297	1.2126015123452356	0.2252822104074541	1.0	0.91502135702069	7	Q93034,Q13617,Q9UJX6,Q13619,Q13618	5
+Cullin homology domain [IPR016158]	0.6047853072228297	1.2126015123452356	0.2252822104074541	1.0	0.91502135702069	7	Q93034,Q13617,Q9UJX6,Q13619,Q13618	5
+FATC domain [IPR003152]	0.738334858188479	1.1918126338521648	0.2333347208439096	1.0	0.91502135702069	3	P78527,P42345	2
+PIK-related kinase [IPR014009]	0.738334858188479	1.1918126338521648	0.2333347208439096	1.0	0.91502135702069	3	P78527,P42345	2
+PIK-related kinase, FAT [IPR003151]	0.738334858188479	1.1918126338521648	0.2333347208439096	1.0	0.91502135702069	3	P78527,P42345	2
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.6532576016462521	1.188973716096007	0.2344500100396502	1.0	0.91502135702069	4	O60749	1
+Sec23/Sec24, trunk domain [IPR006896]	0.5928740533234403	1.1826938026110498	0.2369305212360717	1.0	0.91502135702069	6	Q15436,Q15437	2
+Zinc finger, Sec23/Sec24-type [IPR006895]	0.5928740533234403	1.1826938026110498	0.2369305212360717	1.0	0.91502135702069	6	Q15436,Q15437	2
+Sec23/Sec24, helical domain [IPR006900]	0.5928740533234403	1.1826938026110498	0.2369305212360717	1.0	0.91502135702069	6	Q15436,Q15437	2
+Sec23/Sec24 beta-sandwich [IPR012990]	0.5928740533234403	1.1826938026110498	0.2369305212360717	1.0	0.91502135702069	6	Q15436,Q15437	2
+Protein kinase, C-terminal [IPR017892]	0.6214659603628047	1.179986742649168	0.2380054877479269	1.0	0.91502135702069	5	P51812,Q15418,Q16513	3
+Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]	0.5970157351400392	1.1769417891635006	0.2392187410244814	1.0	0.91502135702069	7	O00443,P78527,P42345,Q9Y4A5	4
+Initiation factor eIF-4 gamma, MA3 [IPR003891]	0.6188114094799914	1.1683879620504682	0.2426503084567977	1.0	0.9199176923046783	5	Q04637,Q53EL6	2
+Class II aldolase/adducin N-terminal [IPR001303]	0.7305196099477187	1.1617629451243938	0.2453317695270431	1.0	0.9203898558735032	3	Q9UEY8	1
+Dbl homology (DH) domain [IPR000219]	0.6170418474681443	1.1606582879072058	0.2457808912604875	1.0	0.9203898558735032	5	Q92974	1
+Marvel domain [IPR008253]	0.936280487804878	1.1575707138766116	0.2470392663156633	1.0	0.9203898558735032	2	Q16625	1
+DNA mismatch repair protein MutS, C-terminal [IPR000432]	0.7276608722171409	1.1507814200698654	0.2498221704072347	1.0	0.9208558731801144	3	P20585,P43246	2
+DNA mismatch repair protein MutS, connector domain [IPR007860]	0.7276608722171409	1.1507814200698654	0.2498221704072347	1.0	0.9208558731801144	3	P20585,P43246	2
+DNA mismatch repair protein MutS, core [IPR007696]	0.7276608722171409	1.1507814200698654	0.2498221704072347	1.0	0.9208558731801144	3	P20585,P43246	2
+DNA mismatch repair protein MutS-like, N-terminal [IPR007695]	0.7276608722171409	1.1507814200698654	0.2498221704072347	1.0	0.9208558731801144	3	P20585,P43246	2
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.9332317073170792	1.1468900241841011	0.2514270761437644	1.0	0.9208558731801144	2	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.9332317073170792	1.1468900241841011	0.2514270761437644	1.0	0.9208558731801144	2	Q9Y282	1
+EB1, C-terminal [IPR004953]	0.9280487804878048	1.1287558116203649	0.2590008580885805	1.0	0.9208558731801144	2	Q15555	1
+Rho GTPase-activating protein domain [IPR000198]	0.5796591279283209	1.122080471860838	0.2618282261030706	1.0	0.9208558731801144	6	Q13017	1
+TOG domain [IPR034085]	0.5793483938617688	1.12065639947698	0.2624341479467311	1.0	0.9208558731801144	6	Q86Y56,Q92616	2
+Alpha/beta hydrolase fold-1 [IPR000073]	0.5717332362268307	1.085780438528582	0.2775761428218382	1.0	0.9208558731801144	6	P07099	1
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.5821425979058545	1.0848373198459642	0.2779937132012291	1.0	0.9208558731801144	8	Q7L5N1,O95630,P51665,O00487,Q6P2Q9	5
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.7102775236352622	1.0841573323605551	0.2782950461573092	1.0	0.9208558731801144	3	Q7L576,Q9NUQ9	2
+Gamma tubulin complex component protein, N-terminal [IPR041470]	0.7081427264409902	1.075996729396229	0.281928719119958	1.0	0.9208558731801144	3	Q96RT7,Q96CW5	2
+Gamma tubulin complex component, C-terminal [IPR040457]	0.7081427264409902	1.075996729396229	0.281928719119958	1.0	0.9208558731801144	3	Q96RT7,Q96CW5	2
+AGC-kinase, C-terminal [IPR000961]	0.5883502419016031	1.0676945086787717	0.2856583362961455	1.0	0.9208558731801144	10	Q15418,O14578,Q13464	3
+NOPS [IPR012975]	0.6986282272460528	1.0396947651426072	0.2984817334568035	1.0	0.9214260140481458	3	P23246	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.901829268292683	1.0375385628744802	0.2994849334060041	1.0	0.9214260140481458	2	P04066	1
+Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]	0.588118360496321	1.0347133931902384	0.3008027793969148	1.0	0.9214260140481458	5	P36915	1
+Acyltransferase, C-terminal domain [IPR032098]	0.6853442876729027	0.9892291669407932	0.3225510311051778	1.0	0.9305604412759274	3	Q6UWP7	1
+Sirtuin family, catalytic core domain [IPR026590]	0.8875	0.9881328016015004	0.3230876130835765	1.0	0.9305604412759274	2	Q96EB6	1
+PA domain [IPR003137]	0.8768292682926904	0.951589556885729	0.3413051798369892	1.0	0.9393882361464646	2	Q8TCT8	1
+v-SNARE, coiled-coil homology domain [IPR042855]	0.673641664084174	0.9450256515085184	0.3446457802933134	1.0	0.9393882361464646	3	P51809	1
+Longin domain [IPR010908]	0.673641664084174	0.9450256515085184	0.3446457802933134	1.0	0.9393882361464646	3	P51809	1
+Cadherin-like [IPR002126]	0.6678865507776712	0.923389168858593	0.3558044341087152	1.0	0.946333584450344	3	P19022,Q02487	2
+Phospholipase D/Transphosphatidylase [IPR001736]	0.8679878048780669	0.9214917881274562	0.3567937266256609	1.0	0.9470800707749668	2	Q8N2A8	1
+EH domain-containing protein, N-terminal [IPR031692]	0.8664634146341462	0.9163203065393536	0.3594989203682304	1.0	0.9470961684642112	2	Q9H223	1
+Domain of unknown function DUF5600 [IPR040990]	0.8664634146341462	0.9163203065393536	0.3594989203682304	1.0	0.9470961684642112	2	Q9H223	1
+AMP-dependent synthetase/ligase [IPR000873]	0.5435997414889194	0.9096796691619792	0.3629914692284504	1.0	0.9470961684642112	8	Q4G176	1
+Citron homology (CNH) domain [IPR001180]	0.8618902439024388	0.9008388338247556	0.367674016593603	1.0	0.947726756369046	2	Q8WUH2	1
+Isochorismatase-like [IPR000868]	0.8539634146341577	0.8741268752073745	0.382049163094182	1.0	0.9597000475235088	2	Q96AB3	1
+ABC transporter type 1, transmembrane domain [IPR011527]	0.5506266440972298	0.8735340177840055	0.3823720728067852	1.0	0.9597000475235088	5	P08183,P28288	2
+ABC transporter-like, ATP-binding domain [IPR003439]	0.5377865102061798	0.8608991021723876	0.3892936162042426	1.0	0.9693881648740956	9	Q9NUQ8,P08183,P28288,O75027,P61221	5
+Zinc finger, RanBP2-type [IPR001876]	0.5363700785352206	0.8545701906919828	0.3927891360475344	1.0	0.9693881648740956	9	P98175,Q01844	2
+Reticulon [IPR003388]	0.5704356588205489	0.8487471959307481	0.3960219782447332	1.0	0.9693881648740956	4	O75298	1
+Heat shock protein Hsp90, N-terminal [IPR020575]	0.5685636977582449	0.8412456749017033	0.4002103174853224	1.0	0.9693881648740956	4	P07900	1
+Dynamin, N-terminal [IPR045063]	0.520308166763702	0.8286994083331853	0.4072745206633241	1.0	0.9693881648740956	7	Q9H223,P50570,O00429,Q9H4M9	4
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.520308166763702	0.8286994083331853	0.4072745206633241	1.0	0.9693881648740956	7	Q9H223,P50570,O00429,Q9H4M9	4
+DNA2/NAM7 helicase-like, C-terminal [IPR041679]	0.5391328984834076	0.8248866321165514	0.4094359564050447	1.0	0.9693881648740956	5	Q9HCE1	1
+Exportin-1/Importin-beta-like [IPR013598]	0.5378524508568518	0.819495854888563	0.4125035659463685	1.0	0.9693881648740956	5	Q96QU8,O14980,Q9HAV4	3
+Myosin tail [IPR002928]	0.5555378703030407	0.7894075842043992	0.4298738245820854	1.0	0.9861083278993804	4	P35580	1
+Cysteine-rich flanking region, C-terminal [IPR000483]	0.8277439024390496	0.7870224662989611	0.4312687147143401	1.0	0.9861083278993804	2	Q13641	1
+Leucine-rich repeat N-terminal domain [IPR000372]	0.8277439024390496	0.7870224662989611	0.4312687147143401	1.0	0.9861083278993804	2	Q13641	1
+Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]	0.8271341463414899	0.7850220924393461	0.4324406156535247	1.0	0.9862745440630304	2	Q15418	1
+AARP2CN [IPR012948]	0.8234756097560989	0.7730461647916775	0.4394950599653693	1.0	0.9874664052147494	2	Q2NL82	1
+Bms1/Tsr1-type G domain [IPR030387]	0.8234756097560989	0.7730461647916775	0.4394950599653693	1.0	0.9874664052147494	2	Q2NL82	1
+Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]	0.8234756097560989	0.7730461647916775	0.4394950599653693	1.0	0.9874664052147494	2	Q2NL82	1
+HECT domain [IPR000569]	0.5109254247771289	0.7642482049062133	0.4447193449513342	1.0	0.9885087325652948	8	Q15386,Q96J02	2
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.8164634146341654	0.7502223866409866	0.4531207780399433	1.0	0.9895358167489938	2	P13674	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.8161585365853656	0.7492340438718271	0.453716153362615	1.0	0.990027165663894	2	O60506	1
+TGS [IPR004095]	0.496127462626429	0.7455634112923769	0.455931192300997	1.0	0.9924300301470398	6	Q9BW92,Q9NTK5	2
+MOSC, N-terminal beta barrel [IPR005303]	0.8109756097561065	0.7324848890637035	0.463872662531823	1.0	0.992727972511418	2	Q96EN8	1
+Molybdenum cofactor sulfurase, C-terminal [IPR005302]	0.8109756097561065	0.7324848890637035	0.463872662531823	1.0	0.992727972511418	2	Q96EN8	1
+EF-hand, Ca insensitive [IPR014837]	0.6146032118766938	0.7274607113864532	0.4669437748227685	1.0	0.992727972511418	3	P12814	1
+Helicase/UvrB, N-terminal [IPR006935]	0.6136017078377685	0.7238737326149282	0.4691432575646233	1.0	0.992727972511418	3	P19447,Q92900	2
+BAG domain [IPR003103]	0.8076219512195204	0.7217014698442387	0.4704780382142357	1.0	0.992727972511418	2	O95429	1
+PTB/PI domain [IPR006020]	0.5116156844812266	0.7105631158012161	0.4773550063048339	1.0	0.9945206016000164	5	Q5SW96	1
+Phospholipid/glycerol acyltransferase [IPR002123]	0.4978881968548332	0.7074600362650351	0.4792806393292248	1.0	0.9959350381259572	8	Q6UWP7,Q9HCL2	2
+Ribosomal protein L30, N-terminal [IPR012988]	0.8030487804878046	0.7070679086975081	0.4795242776162016	1.0	0.9959350381259572	2	Q6DKI1	1
+Ribosomal protein L7, eukaryotic/archaeal [IPR035808]	0.8030487804878046	0.7070679086975081	0.4795242776162016	1.0	0.9959350381259572	2	Q6DKI1	1
+Proteasome component (PCI) domain [IPR000717]	0.5374525964276299	0.7053324991148966	0.4806033401896417	1.0	0.9962681837551868	17	Q9UNS2,O00231,Q99627,Q14152,Q15008,O43242,P60228,P61201,Q9Y262,Q7L2H7	10
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.6060598641926309	0.6970019612596904	0.4858015664186061	1.0	1.0	3	Q99797	1
+Myosin, N-terminal, SH3-like [IPR004009]	0.5080874924662264	0.69616855513609	0.4863232776238795	1.0	1.0	5	P35580	1
+CTP synthase GATase domain [IPR033828]	0.7984756097561152	0.6925190562814021	0.4886114228804654	1.0	1.0	2	P17812	1
+CTP synthase, N-terminal [IPR017456]	0.7984756097561152	0.6925190562814021	0.4886114228804654	1.0	1.0	2	P17812	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.7926829268292682	0.6742167720784961	0.5001735080718381	1.0	1.0	2	P07197	1
+Domain of unknown function DUF1747 [IPR013719]	0.7902439024390241	0.6665541210539749	0.5050569827342994	1.0	1.0	2	Q9Y5B9	1
+CCAAT-binding factor [IPR005612]	0.5919487648673446	0.6474391770314456	0.5173477473346881	1.0	1.0	3	Q03701,Q8WTT2	2
+GTPase effector domain [IPR020850]	0.7814024390243901	0.6390026202253544	0.5228212273286588	1.0	1.0	2	P50570	1
+Dynamin GTPase effector [IPR003130]	0.7814024390243901	0.6390026202253544	0.5228212273286588	1.0	1.0	2	P50570	1
+Dynamin stalk domain [IPR000375]	0.7814024390243901	0.6390026202253544	0.5228212273286588	1.0	1.0	2	P50570	1
+Rpn11/EIF3F, C-terminal [IPR024969]	0.5143856735123238	0.6308632613395869	0.5281299353549456	1.0	1.0	4	P51665,Q7L5N1	2
+Cyclin-like [IPR013763]	0.5864592863678028	0.6284326887957663	0.5297205286002182	1.0	1.0	3	P14635,Q00403	2
+Class I myosin tail homology domain [IPR010926]	0.5837145471180324	0.6189910867063992	0.5359222307652434	1.0	1.0	3	O43795,O94832	2
+Class I myosin, motor domain [IPR036072]	0.5837145471180324	0.6189910867063992	0.5359222307652434	1.0	1.0	3	O43795,O94832	2
+SKP1 component, POZ domain [IPR016073]	0.7685975609756096	0.5997641860986025	0.5486634046045253	1.0	1.0	2	P63208	1
+Cadherin, cytoplasmic domain [IPR000233]	0.7637195121951218	0.5850356269026731	0.5585237615315659	1.0	1.0	2	Q02487	1
+Cadherin prodomain [IPR014868]	0.7637195121951218	0.5850356269026731	0.5585237615315659	1.0	1.0	2	Q02487	1
+PAP/25A-associated [IPR002058]	0.5718392017968437	0.5786435172632829	0.5628297350040625	1.0	1.0	3	Q8NDF8	1
+NAD-dependent epimerase/dehydratase [IPR001509]	0.7612804878048778	0.5777188006929886	0.5634539839105301	1.0	1.0	2	Q16795	1
+Fxr1, tudor domain [IPR041560]	0.7597560975610099	0.5731621591505934	0.566534903264666	1.0	1.0	2	P51114	1
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.7597560975610099	0.5731621591505934	0.566534903264666	1.0	1.0	2	P51114	1
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.7597560975610099	0.5731621591505934	0.566534903264666	1.0	1.0	2	P51114	1
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.7597560975610099	0.5731621591505934	0.566534903264666	1.0	1.0	2	P51114	1
+Agenet-like domain [IPR008395]	0.7597560975610099	0.5731621591505934	0.566534903264666	1.0	1.0	2	P51114	1
+GTP binding domain [IPR006073]	0.4737866182409149	0.5450115151109404	0.5857455979127919	1.0	1.0	11	P36915,Q9NTK5	2
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.4587400307151137	0.5431899201521081	0.5869990459992516	1.0	1.0	8	Q8N3R9	1
+Guanylate kinase-like domain [IPR008144]	0.4587400307151137	0.5431899201521081	0.5869990459992516	1.0	1.0	8	Q8N3R9	1
+Peptidase M41 [IPR000642]	0.7371951219512307	0.5072814635432468	0.6119573428357132	1.0	1.0	2	Q96TA2	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.5456284434253438	0.4928288427714326	0.6221335290797068	1.0	1.0	3	P01889	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.5456284434253438	0.4928288427714326	0.6221335290797068	1.0	1.0	3	P01889	1
+MHC class I-like antigen recognition-like [IPR011161]	0.5456284434253438	0.4928288427714326	0.6221335290797068	1.0	1.0	3	P01889	1
+Immunoglobulin C1-set [IPR003597]	0.5456284434253438	0.4928288427714326	0.6221335290797068	1.0	1.0	3	P01889	1
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.7274390243902435	0.479759929351112	0.6313981087163729	1.0	1.0	2	P43246	1
+Chromo domain [IPR023780]	0.4364045516710495	0.45507706802415	0.6490537951922006	1.0	1.0	8	P83916,O14646,Q14839,Q9HCK8	4
+Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]	0.5315559904466399	0.4488591271099255	0.6535332824750695	1.0	1.0	3	O00443	1
+Zinc finger, double-stranded RNA binding [IPR022755]	0.4619173070562561	0.4455494499109367	0.6559227322172958	1.0	1.0	4	Q5F1R6	1
+BRK domain [IPR006576]	0.7149390243902438	0.4454266918595884	0.6560114263901493	1.0	1.0	2	Q9HCK8	1
+MPN domain [IPR037518]	0.4404964270236478	0.4333461543992224	0.6647633122971424	1.0	1.0	10	Q7L5N1,O95630,P51665,O00487,Q6P2Q9	5
+CNNM, transmembrane domain [IPR002550]	0.7091463414634391	0.4298878413336404	0.66727723042289	1.0	1.0	2	Q6P4Q7	1
+Ion transporter-like, CBS domain [IPR044751]	0.7091463414634391	0.4298878413336404	0.66727723042289	1.0	1.0	2	Q6P4Q7	1
+26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]	0.7036585365853656	0.4153927875699917	0.6778543856746293	1.0	1.0	2	Q15008	1
+DNA ligase, ATP-dependent, C-terminal [IPR012309]	0.6975609756097838	0.3995523089153845	0.6894862888117426	1.0	1.0	2	P18858	1
+DNA ligase, ATP-dependent, N-terminal [IPR012308]	0.6975609756097838	0.3995523089153845	0.6894862888117426	1.0	1.0	2	P18858	1
+DNA ligase, ATP-dependent, central [IPR012310]	0.6975609756097838	0.3995523089153845	0.6894862888117426	1.0	1.0	2	P18858	1
+OCRE domain [IPR041591]	0.6969512195122283	0.3979839042007978	0.6906420504539996	1.0	1.0	2	P98175	1
+Ribosomal protein L26/L24, KOW domain [IPR041988]	0.69390243902439	0.390185177322028	0.6963996215083497	1.0	1.0	2	P61254	1
+Dynein heavy chain, coiled coil stalk [IPR024743]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain AAA lid domain [IPR041658]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain, AAA module D4 [IPR024317]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain, C-terminal domain [IPR041228]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain, ATP-binding dynein motor region [IPR035706]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain region D6 P-loop domain [IPR004273]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain, tail [IPR013594]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Dynein heavy chain, linker [IPR013602]	0.6929878048780485	0.3878597264747074	0.6981198431692863	1.0	1.0	2	Q14204	1
+Ubiquitin-associated domain [IPR015940]	0.4493234311431758	0.3840981843715553	0.7009056771297515	1.0	1.0	15	Q9Y5A7,Q7KZI7,Q7Z6Z7,Q14157,Q9NRR5	5
+Isopropylmalate dehydrogenase-like domain [IPR024084]	0.4411794693982633	0.3795085237992454	0.704310275803834	1.0	1.0	4	P48735	1
+Sec63 domain [IPR004179]	0.5068618481244427	0.3758301258345242	0.7070431897684759	1.0	1.0	3	Q8N3C0,O75643	2
+Plectin/S10, N-terminal [IPR005326]	0.6783536585365851	0.3515658308073668	0.7251638942876384	1.0	1.0	2	P46783	1
+SCP2 sterol-binding domain [IPR003033]	0.4941893381859942	0.3406213105667492	0.7333886843398918	1.0	1.0	3	P51659	1
+Serine/threonine-protein kinase N, C2 domain [IPR037784]	0.6722560975609753	0.3369659387539996	0.7361425769617072	1.0	1.0	2	Q16513	1
+Serine/threonine-protein kinase N, first HR1 domain [IPR037313]	0.6722560975609753	0.3369659387539996	0.7361425769617072	1.0	1.0	2	Q16513	1
+CRAL-TRIO lipid binding domain [IPR001251]	0.6594512195121947	0.3073497526036908	0.7585771699332025	1.0	1.0	2	P21359	1
+Ribosomal L28e/Mak16 [IPR029004]	0.6554878048780486	0.2984769637118887	0.7653391555834894	1.0	1.0	2	P46779	1
+Gamma-glutamyl cyclotransferase-like [IPR013024]	0.6506097560975606	0.2877518828842152	0.773536672021063	1.0	1.0	2	Q8WUX2	1
+Domain of unknown function DUF4217 [IPR025313]	0.4706835980100096	0.2798476208401891	0.7795944145909728	1.0	1.0	3	Q13206	1
+Ubiquitin-like domain [IPR000626]	0.4108184131572796	0.2689003414210459	0.7880063742281038	1.0	1.0	14	P46379	1
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.37294677874762	0.2685109189689948	0.7883060712487	1.0	1.0	6	P98194	1
+Brix domain [IPR007109]	0.401769371568038	0.2684766631824204	0.7883324357825161	1.0	1.0	4	Q9NQ55,Q8TDN6,Q9H7B2	3
+Intermediate filament, rod domain [IPR039008]	0.386779944194955	0.2659014565683927	0.7903151032884996	1.0	1.0	5	P08670,P07197	2
+Chromo domain subgroup [IPR017984]	0.4627999545509166	0.2608730272466691	0.7941904259257389	1.0	1.0	3	P83916	1
+Chromo shadow domain [IPR008251]	0.4627999545509166	0.2608730272466691	0.7941904259257389	1.0	1.0	3	P83916	1
+Coatomer subunit gamma, C-terminal [IPR032154]	0.6347560975609753	0.254418279450792	0.7991724305133014	1.0	1.0	2	Q9Y678	1
+Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]	0.6347560975609753	0.254418279450792	0.7991724305133014	1.0	1.0	2	Q9Y678	1
+SNF2, N-terminal [IPR000330]	0.4124821149531368	0.248840563194257	0.8034841128871115	1.0	1.0	16	Q14527,P28370,P51532,Q14839,Q2NKX8,Q9NRZ9,O14981,O14646,Q9HCK8	9
+RecF/RecN/SMC, N-terminal [IPR003395]	0.3661380902068547	0.2475603607883963	0.8044745836246674	1.0	1.0	6	Q9UQE7,O95347,Q96SB8	3
+Guanine nucleotide exchange factor, N-terminal [IPR032691]	0.6310975609756094	0.247063498713896	0.8048590819809103	1.0	1.0	2	Q7Z3U7	1
+Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]	0.6307926829268291	0.2464564002713838	0.805328951178643	1.0	1.0	2	Q13557	1
+Myosin head, motor domain [IPR001609]	0.3739942990934651	0.2408064449081904	0.8097051342781323	1.0	1.0	8	P35580	1
+Zinc finger, UBR-type [IPR003126]	0.4541018603232861	0.2408013925804706	0.809709050253582	1.0	1.0	3	Q5T4S7,Q8N806	2
+Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]	0.3834590754533539	0.2402669238273158	0.8101233350139319	1.0	1.0	10	O94973,Q9Y678,Q9UBF2,O00203,O14617	5
+Importin-beta, N-terminal domain [IPR001494]	0.3959712447752826	0.2128341964615255	0.8314562898512032	1.0	1.0	15	Q8TEX9,Q92973,P55060,O15397,Q96P70,O95373,Q9UI26	7
+GTP binding protein, second domain [IPR031662]	0.6131097560975607	0.2127920204416597	0.8314891879789126	1.0	1.0	2	P55039	1
+RNA recognition motif domain, eukaryote [IPR003954]	0.3758824347584801	0.205410185208603	0.8372516632952416	1.0	1.0	11	P38159,Q9UHX1	2
+Glycosyl transferase, family 1 [IPR001296]	0.6033536585365851	0.195539073808366	0.8449709515362154	1.0	1.0	2	Q9BT22	1
+RNA polymerase Rpb1, domain 4 [IPR007083]	0.4327538883806112	0.1955231555999822	0.8449834119419315	1.0	1.0	3	P24928,O14802	2
+RNA polymerase Rpb1, domain 5 [IPR007081]	0.4327538883806112	0.1955231555999822	0.8449834119419315	1.0	1.0	3	P24928,O14802	2
+RNA polymerase, alpha subunit [IPR000722]	0.4327538883806112	0.1955231555999822	0.8449834119419315	1.0	1.0	3	P24928,O14802	2
+RNA polymerase, N-terminal [IPR006592]	0.4327538883806112	0.1955231555999822	0.8449834119419315	1.0	1.0	3	P24928,O14802	2
+RNA polymerase Rpb1, domain 1 [IPR007080]	0.4327538883806112	0.1955231555999822	0.8449834119419315	1.0	1.0	3	P24928,O14802	2
+RNA polymerase Rpb1, domain 3 [IPR007066]	0.4327538883806112	0.1955231555999822	0.8449834119419315	1.0	1.0	3	P24928,O14802	2
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]	0.4318389752973508	0.193712284929773	0.846401172068028	1.0	1.0	3	Q96G03,P36871	2
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.599695121951219	0.1893141935451978	0.849846571630809	1.0	1.0	2	Q9NVI7	1
+Suppressor of forked [IPR008847]	0.5981707317073168	0.1867600801903954	0.8518487475376768	1.0	1.0	2	Q12996	1
+mRNA splicing factor Cwf21 domain [IPR013170]	0.59390243902439	0.179732652310306	0.8573624580161667	1.0	1.0	2	O15042	1
+Spt5 C-terminal domain [IPR024945]	0.59390243902439	0.179732652310306	0.8573624580161667	1.0	1.0	2	O00267	1
+Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]	0.4229948154925334	0.1767664636526932	0.8596918323106852	1.0	1.0	3	Q86UV5,Q9Y4E8	2
+DnaJ domain [IPR001623]	0.3858279762756924	0.1651331514905809	0.8688391800759692	1.0	1.0	17	Q8WXX5,Q9NVH1,O75165,Q13217,Q96KC8,Q99543,O75937,Q96EY1,Q5F1R6	9
+Coatomer, WD associated region [IPR006692]	0.5777439024390241	0.1547879091099741	0.8769885234561765	1.0	1.0	2	P53621	1
+Sterile alpha motif domain [IPR001660]	0.3353679109449456	0.1506754568976364	0.8802317347257562	1.0	1.0	7	Q6UWE0,Q13136	2
+Dual specificity phosphatase, catalytic domain [IPR000340]	0.3464598590585602	0.1505095178963813	0.880362642080343	1.0	1.0	4	Q8WUK0,Q9UNI6	2
+Dual specificity protein phosphatase domain [IPR020422]	0.3464598590585602	0.1505095178963813	0.880362642080343	1.0	1.0	4	Q8WUK0,Q9UNI6	2
+Bromo adjacent homology (BAH) domain [IPR001025]	0.3438071995119062	0.146048871183938	0.883882808388291	1.0	1.0	4	P26358,O94776,Q13330	3
+Syntaxin, N-terminal domain [IPR006011]	0.4053064958829026	0.1459421575144485	0.8839670509741189	1.0	1.0	3	O15400,Q86Y82	2
+ENTH  domain [IPR013809]	0.4032710178194749	0.1426585412788483	0.8865598609956271	1.0	1.0	3	Q9Y6I3	1
+Metastasis-associated protein MTA1, R1 domain [IPR035170]	0.56890243902439	0.1422479601779746	0.8868841501766058	1.0	1.0	2	O94776	1
+ELM2 domain [IPR000949]	0.56890243902439	0.1422479601779746	0.8868841501766058	1.0	1.0	2	O94776	1
+Ribosomal protein S5, C-terminal [IPR005324]	0.567682926829268	0.1405795626167636	0.8882020945492743	1.0	1.0	2	P15880	1
+Ribosomal protein S5, N-terminal [IPR013810]	0.567682926829268	0.1405795626167636	0.8882020945492743	1.0	1.0	2	P15880	1
+Importin-alpha, importin-beta-binding domain [IPR002652]	0.3344019165058308	0.140456305585513	0.8882994732844196	1.0	1.0	5	O60684,O00505,P52292	3
+Armadillo repeat-containing domain [IPR006911]	0.4013418725221104	0.1395966166774408	0.888978713946804	1.0	1.0	3	Q8N2F6,Q9UH62	2
+DNA2/NAM7 helicase, helicase domain [IPR041677]	0.3386211104332013	0.137646748044658	0.8905196075486459	1.0	1.0	4	O60306,P51530,Q92900	3
+La protein, xRRM domain [IPR014886]	0.5649390243902436	0.136879734206538	0.8911258578065764	1.0	1.0	2	Q4G0J3	1
+Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]	0.3964623360780823	0.132069345631684	0.8949294421306506	1.0	1.0	3	P23193,Q14241	2
+Immunoglobulin V-set domain [IPR013106]	0.3334350213544925	0.1296641358885636	0.8968321583788061	1.0	1.0	4	Q13740,Q9Y624,Q9BY67	3
+Transcription elongation factor S-II, central domain [IPR003618]	0.3918877706617913	0.1252947415657936	0.90029021500223	1.0	1.0	3	P23193,Q92576	2
+Phox homology [IPR001683]	0.3421711735714506	0.1231498493372141	0.9019884376066584	1.0	1.0	11	Q53T59,Q9UNH7,O60749	3
+Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]	0.5530487804878046	0.1217062466434019	0.9031316659132644	1.0	1.0	2	P26599	1
+Survival motor neuron [IPR010304]	0.5463414634146337	0.113755638700806	0.9094315054272488	1.0	1.0	2	Q16637	1
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.3823925333159961	0.1120978903659981	0.9107457901282384	1.0	1.0	3	Q16134	1
+JmjC domain [IPR003347]	0.3172925406286758	0.1109236694703176	0.9116768759010014	1.0	1.0	7	O75151,Q9H6W3	2
+Malic enzyme, NAD-binding [IPR012302]	0.5390243902439021	0.1055743326905596	0.9159200904601028	1.0	1.0	2	P23368	1
+Malic enzyme, N-terminal domain [IPR012301]	0.5390243902439021	0.1055743326905596	0.9159200904601028	1.0	1.0	2	P23368	1
+Peptidase M20, dimerisation domain [IPR011650]	0.5384146341463412	0.104915462013223	0.916442889768956	1.0	1.0	2	Q8IYS1	1
+Potentiating neddylation domain [IPR005176]	0.3734242387659061	0.1006906944820235	0.9197959985577407	1.0	1.0	3	Q9BTE7	1
+Butyrophylin-like, SPRY domain [IPR003879]	0.3598658127477958	0.085342817871866	0.9319888519409704	1.0	1.0	3	O15344,Q12899	2
+SPRY-associated [IPR006574]	0.3598658127477958	0.085342817871866	0.9319888519409704	1.0	1.0	3	O15344,Q12899	2
+Helicase/SANT-associated domain [IPR014012]	0.3528514791094883	0.078269834867592	0.9376134121190882	1.0	1.0	3	P51532,Q6ZRS2	2
+WW domain [IPR001202]	0.3139515610686067	0.0781529257870021	0.9377064072076426	1.0	1.0	10	P46939,P46940,Q96J02,O00213,Q8N1G2	5
+Histidine kinase/HSP90-like ATPase [IPR003594]	0.3038381891004628	0.0770435836313779	0.938588873257674	1.0	1.0	8	P08238,P07900	2
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.2824893227577865	0.0723351694088538	0.9423351768514756	1.0	1.0	4	Q86TI2,P48147,Q4J6C6	3
+Pentacotripeptide-repeat region of PRORP [IPR033443]	0.5012195121951217	0.0710761896341338	0.9433371181531548	1.0	1.0	2	O75127	1
+Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]	0.3389253186271068	0.0658935518145993	0.947462574333792	1.0	1.0	3	O60256	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.3382128697773731	0.0653177809499796	0.9479209854242454	1.0	1.0	3	Q5BKZ1,Q9ULX6	2
+TRIAD supradomain [IPR044066]	0.334553123106423	0.0624450850234831	0.9502083923342086	1.0	1.0	3	Q9UBS8	1
+IBR domain [IPR002867]	0.334553123106423	0.0624450850234831	0.9502083923342086	1.0	1.0	3	Q9UBS8	1
+F-box domain [IPR001810]	0.2876335877862526	0.0592735488450269	0.9527342290260896	1.0	1.0	7	Q9Y2K7,Q9Y3I1,Q14241,Q8TB52,Q8NEZ5,Q96ME1	6
+BRCT domain [IPR001357]	0.2930033608310446	0.0532263770755501	0.9575515395317578	1.0	1.0	9	P35251,P49916,P38398,P09874,O00541,Q9H8V3,P18887,Q12888	8
+SWIB/MDM2 domain [IPR003121]	0.4685975609756093	0.0506785930065819	0.9595816350313544	1.0	1.0	2	P41214	1
+CBS domain [IPR000644]	0.2809766780605789	0.0499482843218488	0.960163599970964	1.0	1.0	7	P51790,Q6P4Q7,Q8NE01,P54619	4
+SMCs flexible hinge [IPR010935]	0.2679279829111883	0.0482492281140491	0.9615176174836536	1.0	1.0	5	Q9UQE7,O95347,A6NHR9,Q9NTJ3	4
+Amine oxidase [IPR002937]	0.4536585365853653	0.0437850044157805	0.9650757803634816	1.0	1.0	2	Q8NB78	1
+LRRC8, pannexin-like TM region [IPR021040]	0.4442073170731702	0.0401091158138429	0.9680061342827568	1.0	1.0	2	Q8TDW0	1
+Zinc finger, CW-type [IPR011124]	0.4411585365853653	0.0390277894671374	0.9688682326962332	1.0	1.0	2	Q8NB78	1
+Alpha-D-phosphohexomutase, C-terminal [IPR005843]	0.4317073170731702	0.0359775214258001	0.9713002826517412	1.0	1.0	2	Q96G03	1
+Zinc finger, PARP-type [IPR001510]	0.4109756097560971	0.030712596543948	0.9754987453128516	1.0	1.0	2	P49916	1
+PI31 proteasome regulator,  N-terminal [IPR021625]	0.3954268292682922	0.0278430397439874	0.9777873385044552	1.0	1.0	2	Q92530	1
+THUMP domain [IPR004114]	0.3920731707317069	0.0273263312684217	0.9781994553921972	1.0	1.0	2	Q9NXG2	1
+MRG domain [IPR026541]	0.388414634146341	0.0267998887532021	0.9786193419492756	1.0	1.0	2	Q9UBU8	1
+Ubiquitin conjugation factor E4, core [IPR019474]	0.3856707317073167	0.0264293874981142	0.978914854498716	1.0	1.0	2	Q14139	1
+Chromo/chromo shadow domain [IPR000953]	0.2746685826390622	0.0259323981296203	0.9793112587598598	1.0	1.0	10	P83916,O14646,Q9HCK8	3
+LEM-like domain [IPR013146]	0.3817073170731703	0.0259292029405595	0.9793138072949106	1.0	1.0	2	P42167	1
+RNA polymerase Rpb2, domain 3 [IPR007645]	0.2905487804878044	0.0213741926338176	0.9829471601567508	1.0	1.0	2	P30876	1
+RNA polymerase, beta subunit, protrusion [IPR007644]	0.2905487804878044	0.0213741926338176	0.9829471601567508	1.0	1.0	2	P30876	1
+RNA polymerase Rpb2, domain 7 [IPR007641]	0.2905487804878044	0.0213741926338176	0.9829471601567508	1.0	1.0	2	P30876	1
+DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]	0.2905487804878044	0.0213741926338176	0.9829471601567508	1.0	1.0	2	P30876	1
+RNA polymerase Rpb2, domain 2 [IPR007642]	0.2905487804878044	0.0213741926338176	0.9829471601567508	1.0	1.0	2	P30876	1
+High mobility group box domain [IPR009071]	0.2531341728580627	0.0047933859350273	0.9961754460143196	1.0	1.0	11	Q08945,P54277,O96028	3