Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Copi mediated anterograde transport 0.5806843297524256 3.254012914628689 0.0011378710675598 0.801220352714677 0.5279468017305039 58 P24390,Q9BVA1,Q13190,O95249,O15498,O43731,Q9Y3B3,Q9BUF5,P68371,P04350,Q13885,Q15363 12 Copi dependent golgi to er retrograde traffic 0.626721798499426 3.1602289567235955 0.0015764520475927 0.893408399082624 0.5279468017305039 50 P24390,Q9BVA1,Q9P2W9,O43731,Q9Y3B3,Q9BUF5,P68371,P04350,Q13885,Q12981,P49755,O15260,Q15363 13 Protein localization 0.5755237843537861 3.071707639438602 0.0021283807609513 0.9513639817278354 0.5279468017305039 74 Q9NS69,P50402,O60830,Q99595,P09601,Q9Y512,Q13505,Q9NR77,Q8N4H5,P49069,O43681,Q9Y5J9,P21796,P51648,O75431,P28288,O43615,P46379,P12236,O15228,Q2T9J0,Q13190,Q9Y276,P12235,Q10713,O96008,O43808,P56589,Q15388,O14925,Q6QHF9,O75381,Q9BY49 33 Selective autophagy 0.7002724790323042 3.0338516915901663 0.0024145309681333 0.9676247964129088 0.5279468017305039 32 Q8IWA4,Q15388,Q9BVA1,Q9NS69,Q9BUF5,P68371,P04350,Q8N4H5,Q13885,P54646,O95140,P21796 12 Sphingolipid metabolism 0.7082284304525939 2.963766312919658 0.003038989734666 0.9866853759760192 0.5279468017305039 26 O95470,P04062,P07602,P17900,Q06136,Q96G23,P51648,Q13510,Q16880,Q9NZJ7,P27544 11 Nuclear envelope ne reassembly 0.5983503815284622 2.928696079157756 0.0034038706562491 0.9920797433495846 0.5279468017305039 50 Q14739,Q9BTX1,Q9BVA1,P42167,Q9BUF5,Q8NFH4,P68371,P04350,Q13885,Q86Y07,Q86XL3 11 Autophagy 0.5900663325489243 2.910722320507369 0.0036059432778543 0.9940602085455152 0.5279468017305039 51 Q8IWA4,Q15388,Q9BVA1,Q9NS69,Q9Y2Q5,Q9BUF5,P68371,P04350,Q7Z3C6,Q8N4H5,Q13885,P54646,O95140,P21796 14 Slc mediated transmembrane transport 0.7919686589133895 2.903064276888604 0.0036953078532016 0.9947700534106302 0.5279468017305039 19 Q8TB61,P05141,P55011,Q70HW3,P35613,P53985,P12235,P12236,Q8NEW0,P30825,Q9UBX3 11 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.5367351865637825 2.8734724182652167 0.0040598652625176 0.9968885763547858 0.5279468017305039 62 O75306,O43676,Q9UDW1,P21912,O75880,P03886,O75964,O14949,P56134,Q99643,O75438,O96000,Q9NPL8,Q86Y39,O95168,P24539,P56385,Q9Y6M9,Q9P0J0,O43819,P13073,P51970,P00403,Q16134,P20674 25 Glycerophospholipid biosynthesis 0.6851158100730186 2.8503016624304864 0.0043677781808268 0.9979936783492388 0.5279468017305039 28 P48651,Q53H12,Q8NCC3,Q8NF37,Q9NQZ5,Q9NP80,Q96N66,Q9NPH0,Q99943,Q9HCL2,Q86UL3,Q8IV08,Q8N2A8,O95674 14 Ire1alpha activates chaperones 0.6927228154837326 2.849862879928213 0.0043738080666728 0.9980108467402948 0.5279468017305039 25 O43731,O95070,O14773,Q9Y5M8,Q9NWM8,P43307,O76024 7 Mitochondrial protein import 0.6637903874664095 2.81208705612634 0.0049221179514915 0.999089695334815 0.5279468017305039 33 Q15388,Q9NS69,O60830,Q9Y276,Q99595,O14925,Q9Y512,P12235,Q13505,Q8N4H5,Q10713,P12236,Q9Y5J9,P21796,O75431 15 Rho gtpases activate iqgaps 0.8968097715563756 2.7686741743211867 0.0056284892020812 0.9996676718782006 0.5279468017305039 12 Q9BVA1,Q13885,P68371,P04350 4 Phospholipid metabolism 0.589201241829703 2.758140294608735 0.0058131243195291 0.9997446543525068 0.5279468017305039 48 Q8NF37,Q9NQZ5,Q9NP80,Q8N2A8,P48651,Q53H12,Q8NCC3,Q8N9F7,Q8IV08,O15228,P20339,Q9NPH0,Q99943,Q86UL3,Q10713,O95674,Q96N66,Q9NTJ5,Q9HCL2 19 Metabolism of steroids 0.5966410564160427 2.7318089317174907 0.0062987657821342 0.9998723497468794 0.5279468017305039 46 Q14739,P38435,Q14534,P04062,Q16850,Q15800,Q15392,P30536,P37268,Q9UBM7,O75845,O76062,Q53GQ0,Q15125,Q8NBQ5 15 Golgi to er retrograde transport 0.5346497960865868 2.6850019788557966 0.0072529376776739 0.9999673420860172 0.5279468017305039 74 P24390,Q9BVA1,Q9P2W9,O43731,Q9Y3B3,Q9BUF5,P68371,P04350,Q10472,Q13885,Q12981,P49755,O15260,Q15363 14 Kinesins 0.7291019209140475 2.665190964205962 0.0076944615577669 0.9999826282187976 0.5279468017305039 20 Q9BVA1,Q13885,P68371,P04350 4 Cilium assembly 0.5191554844367174 2.661074005649073 0.0077891834917758 0.999984828965349 0.5279468017305039 65 A0AVF1,P43034,Q9BVA1,O94927,P07437,P04350,A6NIH7,Q13885,P49368,P17987,P68371,Q8NCM8,O43924,Q15051,Q10713,P78371,Q15019,O43805,P41208,Q9BUF5 20 Recycling pathway of l1 0.7073132947372556 2.6545509356179977 0.0079414049224559 0.99998779710285 0.5279468017305039 21 Q9BVA1,Q13885,P68371,P04350 4 Gap junction assembly 0.9700755374782104 2.6292525951030647 0.0085572772655402 0.999994944477261 0.5279468017305039 5 Q9BVA1,Q13885,P68371,P04350 4 Transport of connexons to the plasma membrane 0.9700755374782104 2.6292525951030647 0.0085572772655402 0.999994944477261 0.5279468017305039 5 Q9BVA1,Q13885,P68371,P04350 4 Assembly and cell surface presentation of nmda receptors 0.8761933613147014 2.601517573429817 0.0092812309830658 0.999998206900363 0.5335199383160673 11 Q9BVA1,Q13885,P68371,P04350 4 Cholesterol biosynthesis 0.754305787724204 2.5915409786200345 0.0095547161617561 0.9999987881105644 0.5335199383160673 18 Q14739,Q14534,Q16850,Q15800,Q15392,O75845,P37268,Q9UBM7,O76062,Q15125 10 Respiratory electron transport 0.5358992062328515 2.544259871721105 0.010950957804986 0.999999836282124 0.5335199383160673 53 O75306,O43676,Q9UDW1,P21912,O75880,P03886,O14949,Q99643,O75438,O96000,Q9NPL8,Q86Y39,O95168,Q9Y6M9,Q9P0J0,P13073,O43819,P51970,P00403,Q16134,P20674 21 Gap junction trafficking and regulation 0.8601637066320897 2.5288366271880585 0.0114441283418655 0.9999999193264478 0.5335199383160673 11 Q9BVA1,Q13885,P68371,P04350 4 Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.6213298212026207 2.515962633744558 0.0118707767503232 0.9999999562778054 0.5335199383160673 33 Q9BVA1,Q13885,P68371,P04350 4 Activation of nmda receptors and postsynaptic events 0.638773009656957 2.5000998093695843 0.0124158321108158 0.9999999800163428 0.5335199383160673 25 Q9BVA1,Q13885,P68371,P04350 4 Sealing of the nuclear envelope ne by escrt iii 0.8519009426422578 2.4911213195175024 0.0127340629861039 0.9999999873507948 0.5335199383160673 11 Q9BVA1,Q13885,P68371,P04350 4 Post chaperonin tubulin folding pathway 0.8613556692880265 2.4668114637096545 0.0136322113641389 0.9999999965232576 0.5335199383160673 10 Q9BVA1,Q13885,P68371,P04350 4 Transport of vitamins nucleosides and related molecules 0.9160938726455256 2.466451752618424 0.0136459110666005 0.9999999965911088 0.5335199383160673 6 Q8TB61,P12236,P12235 3 Activation of ampk downstream of nmdars 0.8860036937957124 2.4513297266203633 0.0142329508122684 0.9999999985353712 0.5335199383160673 8 Q9BVA1,Q13885,P68371,P04350 4 Carboxyterminal post translational modifications of tubulin 0.9063314251870344 2.426287954608392 0.0152541615790577 0.999999999663508 0.5335199383160673 6 Q9BVA1,Q13885,P68371,P04350 4 Mitochondrial calcium ion transport 0.7567644899247964 2.4155960562906342 0.0157094783019327 0.9999999998254312 0.5335199383160673 16 O95202,Q99623,P45880,Q9Y277,Q9H300,Q10713,P21796 7 Neuronal system 0.5072074120823171 2.3875673732855485 0.0169602937647459 0.99999999997127 0.5335199383160673 55 Q9BVA1,P68371,P04350,P21964,Q13885,O95197 6 Intra golgi and retrograde golgi to er traffic 0.5362104490390047 2.3808817212527016 0.0172712564890424 0.9999999999816616 0.5335199383160673 98 P24390,O43731,Q15042,P43034,Q9BVA1,O60476,O00461,O60499,Q7Z6M1,P04350,Q10472,Q13885,Q12981,Q9UID3,Q9H0U4,O95249,Q13190,Q9P2W9,O15498,Q16706,P68371,P63167,P20645,P61923,P49755,O15260,Q15363,Q5VIR6,O60664,Q9Y3B3,Q9BUF5,Q96JB2,P48444,O43493,Q8TBA6 35 Sphingolipid de novo biosynthesis 0.8354386045643866 2.3498645516365126 0.0187802436902577 0.999999999997928 0.5335199383160673 10 O95470,Q96G23,Q06136,P51648,P27544 5 Mitophagy 0.8201146057192812 2.344425760092344 0.0190564039051632 0.9999999999986104 0.5335199383160673 11 Q8IWA4,Q15388,Q9NS69,Q8N4H5,O95140,P21796 6 Aggrephagy 0.7428672955998169 2.342214558955241 0.0191696910867964 0.9999999999988204 0.5335199383160673 16 Q9BVA1,Q13885,P68371,P04350 4 Recruitment of numa to mitotic centrosomes 0.5841995740615419 2.3381064735062975 0.0193817254910304 0.999999999999132 0.5335199383160673 37 Q9BVA1,P41208,P07437,P68371,P04350,Q13885 6 Copi independent golgi to er retrograde traffic 0.6049554166078179 2.326328187293986 0.0200010494119837 0.9999999999996458 0.5335199383160673 29 Q9BVA1,Q13885,P68371,P04350 4 Er to golgi anterograde transport 0.5038636678914163 2.2861501084152955 0.0222454783794727 0.9999999999999865 0.5335199383160673 81 P24390,Q96PC5,Q9BVA1,O95249,Q13190,O15498,O43731,Q9Y3B3,Q9BUF5,P68371,P04350,Q13885,Q15363 13 Pink1 prkn mediated mitophagy 0.8412236396995816 2.2569672558299154 0.0240101208895486 0.999999999999999 0.5335199383160673 8 Q8IWA4,Q15388,Q9NS69,Q8N4H5,O95140,P21796 6 Formation of tubulin folding intermediates by cct tric 0.768409598007026 2.2350915811155505 0.0254113369766171 1.0 0.5335199383160673 13 Q9BVA1,Q13885,P68371,P04350 4 Protein folding 0.5763611270057608 2.232057493973395 0.0256111632690556 1.0 0.5335199383160673 35 P04062,Q9BVA1,P68371,P04350,Q13885 5 Synthesis of pa 0.8272442342590949 2.195380834068026 0.0281362907723157 1.0 0.5335199383160673 8 Q8NF37,Q9NPH0,Q99943,Q86UL3,Q8N2A8,Q9HCL2 6 Cristae formation 0.65653517088928 2.134656793256285 0.0327890547058886 1.0 0.5540229432919066 19 Q9NVH1,Q5XKP0,Q9Y512,Q13505,P24539,Q9BUR5,P56385,O75964,Q6UXV4,P56134,O75431 11 Neurotransmitter receptors and postsynaptic signal transmission 0.5597734067628826 2.1289156670059817 0.0332612383236652 1.0 0.5540229432919066 36 Q9BVA1,Q13885,P68371,P04350 4 Egr2 and sox10 mediated initiation of schwann cell myelination 0.8339017210593493 2.1222775633094324 0.0338144364624677 1.0 0.5540229432919066 6 Q9NR77 1 Transport to the golgi and subsequent modification 0.4908600455167078 2.1140442352766953 0.0345114893506828 1.0 0.5540229432919066 84 P24390,Q96PC5,Q9BVA1,O95249,Q13190,O15498,O43731,Q9Y3B3,Q9BUF5,P68371,P04350,Q13885,Q15363 13 Class i peroxisomal membrane protein import 0.7953755315839927 2.1075836032912334 0.0350670231092264 1.0 0.5540229432919066 9 P28288,Q9NR77,O43808,P51648,P56589 5 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.6989747133810498 2.1062031387846747 0.0351867106359236 1.0 0.5540229432919066 16 Q9BVA1,Q13885,P68371,P04350 4 Intraflagellar transport 0.7396213738896118 2.0912711693535724 0.0365037627204383 1.0 0.5630308619598041 13 Q9BVA1,Q13885,P68371,P04350 4 Heme degradation 0.9310107134032442 2.0774287187807996 0.037762007859637 1.0 0.5761751521809131 4 P09601 1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.9161222243146728 2.018594159803673 0.0435294185399579 1.0 0.5933107412772811 4 P12235,P12236 2 Peptide ligand binding receptors 0.7963435463732652 2.00726993248093 0.0447209288666803 1.0 0.5933107412772811 7 P42892,Q9NZJ7,P07602 3 Class a 1 rhodopsin like receptors 0.7963435463732652 2.00726993248093 0.0447209288666803 1.0 0.5933107412772811 7 P42892,Q9NZJ7,P07602 3 Ras processing 0.8061923799102555 2.003172032754534 0.0451588264373474 1.0 0.5933107412772811 6 O43924,O60725 2 Mhc class ii antigen presentation 0.4666385017139505 1.9966671979444737 0.0458613477213565 1.0 0.5933107412772811 55 Q9BVA1,Q13885,P68371,P04350 4 Synthesis of very long chain fatty acyl coas 0.7679186411115118 1.9813554983662072 0.0475514206272149 1.0 0.6078870799100723 9 Q53GQ0,Q9P035,Q9NZ01 3 Diseases associated with n glycosylation of proteins 0.799511556782827 1.974227144304698 0.0483559208122563 1.0 0.6126522467195695 6 Q9BT22,O75352,Q2TAA5 3 Initiation of nuclear envelope ne reformation 0.6359418006120002 1.9195894860842904 0.0549097731413004 1.0 0.6334712852642707 18 Q14739,P42167,Q86Y07,Q86XL3 4 Fatty acyl coa biosynthesis 0.6332955964502526 1.9039599914778749 0.0569153949713827 1.0 0.6461035637151371 18 Q9P035,Q6Y1H2,P50897,Q53GQ0,Q9NZ01 5 Organelle biogenesis and maintenance 0.4898567543880938 1.8904071039831405 0.0587035340487116 1.0 0.6507837094931392 100 A0AVF1,Q5XKP0,Q9Y512,Q13505,P43034,Q9BUR5,O75964,P56134,O75431,Q9BVA1,O94927,P07437,P04350,A6NIH7,Q16891,Q13885,O00411,P49368,P17987,P68371,Q8NCM8,O43924,P24539,P56385,Q15051,Q10713,Q6UXV4,P78371,Q15019,O43805,Q9NVH1,P41208,Q9BUF5,P54646 34 Transmission across chemical synapses 0.5024496966173335 1.8786873712070895 0.0602871931990871 1.0 0.6553544839229908 44 Q9BVA1,P68371,P04350,P21964,Q13885 5 Biological oxidations 0.4944454622047453 1.8745572131007968 0.0608536641458179 1.0 0.6553544839229908 46 Q8TB61,O43169,Q16850,O14880,Q06520,Q6QHF9,Q9NX62,P16435,P21964,Q9NUJ1,P07099,P27338,Q99735 13 Transport of inorganic cations anions and amino acids oligopeptides 0.7439748119802958 1.869878085424049 0.0615007496543416 1.0 0.6553544839229908 9 Q70HW3,P30825,P55011,Q9UBX3 4 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.703520684481108 1.8435957120357809 0.065242081406988 1.0 0.6660324713418422 12 P50402,P09601,P46379,P49069,P51648 5 Metabolism of steroid hormones 0.7757942978674367 1.8146095749092956 0.0695839300106273 1.0 0.6782778717689012 5 P30536,Q53GQ0 2 Synthesis of pc 0.7614481381466394 1.807670999463672 0.0706577207531873 1.0 0.6782778717689012 6 Q9NQZ5 1 Unfolded protein response upr 0.493303473320854 1.7704205230503811 0.0766571133832663 1.0 0.6928435916614961 43 Q9Y3B2,O43731,O95070,O14773,Q9Y5M8,Q9HCU5,Q9NWM8,P43307,O76024 9 Gpcr ligand binding 0.7192174280126326 1.7532836367788225 0.0795533328375317 1.0 0.7099759704179719 9 P42892,Q9BYT8,Q9NZJ7,P07602 4 Response to elevated platelet cytosolic ca2 0.516573370507493 1.7396068265556772 0.0819280797434387 1.0 0.7176292910860468 33 O94919,Q8NBX0,P07602,Q9UEU0,O43852,Q8NBM8,Q6UXV4,Q92520,Q9NZJ7 9 Rhoa gtpase cycle 0.4451009229559062 1.7347918251115737 0.0827776846893568 1.0 0.7206229114981435 54 Q14739,Q13190,Q8TAA9,P42167,O15498,Q9NRG9,P49257,P52735,O15173,P30519,P61586,Q15904,P63167,P51572,P27105,P28288 16 Fatty acid metabolism 0.4207489250430603 1.72680096972309 0.0842034142907814 1.0 0.7234611775923055 60 O43772,Q9UMR5,Q9P035,Q9H7Z7,Q6Y1H2,P50897,Q9NZ01,Q15165,Q53GQ0,P54646,Q8IVS2,O43808,P50416,P51648,Q9BY49 15 Alpha oxidation of phytanate 0.7556606737148217 1.7262748131439694 0.0842979843542641 1.0 0.7234611775923055 5 O43808,P51648 2 Rho gtpases activate formins 0.4260228433255611 1.7234286139080544 0.084811044139597 1.0 0.7234611775923055 64 Q9BVA1,Q92674,Q9BUF5,Q8NFH4,P68371,P04350,P61586,Q13885,Q15005 9 L1cam interactions 0.4855293217323039 1.703682953685446 0.0884403344471043 1.0 0.7234611775923055 43 Q9BVA1,Q13885,P68371,P04350 4 Incretin synthesis secretion and inactivation 0.7491544277997197 1.6975927970891982 0.0895846432338234 1.0 0.7234611775923055 5 P67812 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7491544277997197 1.6975927970891982 0.0895846432338234 1.0 0.7234611775923055 5 P67812 1 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.5909904934561265 1.6505468292549563 0.098831143608832 1.0 0.7463110507699546 18 Q07065,O76024,Q02818,P07237 4 Heparan sulfate heparin hs gag metabolism 0.8237429049207603 1.6470300554902515 0.0995518682653697 1.0 0.7463110507699546 4 Q7LGA3,P54802 2 Cytosolic sulfonation of small molecules 0.7230382908136233 1.636910874418796 0.1016490934253775 1.0 0.7463110507699546 6 Q8TB61,Q06520 2 Translocation of slc2a4 glut4 to the plasma membrane 0.489266516703783 1.6347538094231 0.1021006673204671 1.0 0.7463110507699546 39 Q9BVA1,Q13885,P68371,P04350 4 Metabolism of porphyrins 0.6939712070694631 1.6330645484538575 0.1024554216992787 1.0 0.7463110507699546 9 P22830,P09601,P30519 3 The role of gtse1 in g2 m progression after g2 checkpoint 0.4464413771502271 1.618357429013185 0.1055855908248177 1.0 0.7463255619257562 51 Q9BVA1,Q9BUF5,P68371,P04350,Q13885 5 Rhog gtpase cycle 0.4829280572276357 1.604565188361094 0.1085895276136033 1.0 0.7463255619257562 40 Q14739,Q13190,Q8TAA9,P50402,P42167,O15498,P52735,O95202,O15173,Q7L576,O96013,Q6IAA8,Q86Y07,Q86XL3 14 Complex i biogenesis 0.5068746474655543 1.6029442619122358 0.1089469604080961 1.0 0.7463255619257562 28 Q86Y39,O43676,P03886,O75438,Q9Y6M9,Q9P0J0 6 Glycosphingolipid metabolism 0.6088251597146902 1.6013045812297593 0.1093094748407899 1.0 0.7463255619257562 16 P04062,P07602,Q13510,Q16880,Q9NZJ7 5 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.508193211788535 1.5785268956433962 0.1144446142960313 1.0 0.7660231494625873 23 Q9BT22,O75352,Q2TAA5,Q86YN1 4 Iron uptake and transport 0.5773319473295011 1.56735256496843 0.1170323050134714 1.0 0.7760226206267098 18 P09601,P30519,Q9Y487 3 Vitamin d calciferol metabolism 0.9410596167783628 1.5640979655451297 0.1177945636886914 1.0 0.7774441203453636 3 P04062 1 Anchoring of the basal body to the plasma membrane 0.4917195462012438 1.5606034427909357 0.1186173459622115 1.0 0.779250064446195 34 O94927,P41208,P07437,Q9H6D7,P07900,P68371,P04350,P63167,P43034,Q15051,Q15019,O43805 12 O linked glycosylation 0.8004861648988116 1.5520003065589152 0.1206621502564027 1.0 0.7850458319257566 4 Q10472,Q8NAT1 2 Translation of sars cov 2 structural proteins 0.5948377910708946 1.5206617160076132 0.1283447506557464 1.0 0.8014466393545224 16 Q9H0U3,Q99873,P04843,Q16706,P46977,Q10472,P04844,P27824 8 Hcmv infection 0.4145681221051521 1.5185620985494477 0.1288727574533144 1.0 0.8014466393545224 56 Q9BTX1,Q9BVA1,Q9BUF5,P68371,P04350,Q13885 6 Gamma carboxylation hypusine formation and arylsulfatase activation 0.6393444725267188 1.5148541711914614 0.1298093383920526 1.0 0.8014466393545224 12 P38435,Q9BU89,O60725,Q7L8W6,Q9HA64,P49366 6 Signaling by hedgehog 0.4010631375074472 1.513001411442383 0.1302793003337219 1.0 0.8014466393545224 60 P61289,Q9BVA1,P49721,O43242,P48556,P07237,Q9BUF5,P68371,P04350,P28072,Q14997,Q13616,Q8NCM8,Q13885,Q6PHR2,P48729,Q13438,O75832 18 Hedgehog off state 0.4272705647306477 1.5127037022024237 0.1303549387668059 1.0 0.8014466393545224 53 Q9BVA1,Q9BUF5,P68371,P04350,Q13885 5 Transport of bile salts and organic acids metal ions and amine compounds 0.9233449477351904 1.4950103002696633 0.1349117539780504 1.0 0.8099802387151227 3 Q8NEW0,P53985 2 Hcmv early events 0.4484206116154072 1.493502881940269 0.1353056004368984 1.0 0.8099802387151227 47 Q9BTX1,Q9BVA1,Q9BUF5,P68371,P04350,Q13885 6 Synthesis of pips at the golgi membrane 0.6592764368391537 1.4658765788302948 0.1426819136722612 1.0 0.823031038621702 9 Q9NTJ5,Q10713,Q01968,Q9UBF8 4 Factors involved in megakaryocyte development and platelet production 0.4377648173470496 1.460800702315867 0.1440701430502495 1.0 0.8243368265657425 49 Q9BVA1,Q9BUF5,P68371,P04350,Q13885 5 Sars cov 2 infection 0.4901603279451667 1.4473301279377997 0.1478044848840491 1.0 0.8304716941327009 23 Q9H0U3,Q99873,Q96FZ7,P04843,Q16706,P61803,P46977,Q10472,P48729,P04844,P27824 11 Synthesis of pg 0.9105691056910524 1.4451468119376585 0.1484166524889703 1.0 0.8304716941327009 3 O95674,Q8N2A8 2 Recruitment of mitotic centrosome proteins and complexes 0.47823169764002 1.4389219832652245 0.1501726282782711 1.0 0.8304716941327009 33 O94927,P41208,P07437,Q9H6D7,P07900,P68371,P04350,P63167,P43034,O75935,O43805 11 Intra golgi traffic 0.5913558369670853 1.4333584665944623 0.1517554213414378 1.0 0.8304716941327009 15 O95249,Q13190,O00461,O15498,Q16706,Q96JB2,Q8TBA6 7 Resolution of sister chromatid cohesion 0.4019242504149715 1.4323900003658625 0.1520322387230093 1.0 0.8304716941327009 66 Q9BVA1,Q92674,Q9BUF5,Q8NBT2,Q8NFH4,P68371,P04350,Q6P1K2,P63167,P43034,Q13885,Q7L7X3,Q15005 13 Post translational modification synthesis of gpi anchored proteins 0.6667874068818885 1.3826931974477168 0.166758958612768 1.0 0.8863311215739305 6 Q9Y2B2,Q92643 2 Energy dependent regulation of mtor by lkb1 ampk 0.6589626294473698 1.3826485216986366 0.1667726634673991 1.0 0.8863311215739305 7 Q6IAA8,Q9Y2Q5,P54646 3 Maturation of sars cov 2 spike protein 0.6231601177260906 1.3794226154536116 0.1677644903870199 1.0 0.8882754173850047 11 Q9H0U3,Q16706,P46977,P04844,P27824 5 Platelet calcium homeostasis 0.674333091547393 1.363799235373928 0.1726307610227477 1.0 0.8961848927862983 5 P20020,P16615 2 Aurka activation by tpx2 0.4679319850291167 1.356764008998433 0.1748562067529007 1.0 0.9022580268449676 33 O94927,O75330,P41208,P07437,Q9H6D7,P07900,P68371,P04350,P63167,P43034,O43805 11 Phase ii conjugation of compounds 0.4713308466346332 1.35010786754024 0.1769813850839861 1.0 0.9075802553486652 30 Q8TB61,O14880,Q06520,Q9NX62,P21964,Q99735 6 Asparagine n linked glycosylation 0.469921663985833 1.345246581604707 0.1785456179134099 1.0 0.9113533518673694 127 P24390,O43731,Q9BUN8,P04844,Q9BVA1,Q9BT22,P46977,P04350,Q9HCU5,Q13885,Q2TAA5,Q96PC5,Q9H0U4,O95249,Q13190,O15498,Q9H0U3,Q16706,P68371,P63167,O75352,P49755,Q15363,Q9H3H5,P49257,Q86YN1,P04843,Q9Y3B3,Q9BUF5,Q96JB2,P48444,Q13438,P27824 33 P75ntr regulates axonogenesis 0.875265339129552 1.3074042208641836 0.1910754645978722 1.0 0.9414447370291 3 Q9NQC3 1 The citric acid tca cycle and respiratory electron transport 0.4271186762569972 1.2967703555531669 0.1947102134608109 1.0 0.9527372168996232 95 O75306,O43676,P35613,Q9UDW1,P21912,P03886,O95563,O75964,O14949,P21796,P56134,Q99643,Q9H9P8,O75438,Q9NPL8,Q86Y39,O95168,P24539,P56385,Q9Y6M9,Q9P0J0,P13073,O43819,P51970,P53985,P00403,Q16134,P20674,Q13423 29 Miscellaneous transport and binding events 0.6249763713661516 1.259524935902997 0.2078407892650617 1.0 0.968531612291084 8 Q8N4V1 1 Reduction of cytosolic ca levels 0.7293939153296234 1.259499714603277 0.2078498932467241 1.0 0.968531612291084 4 P20020,P16615 2 Wax and plasmalogen biosynthesis 0.7290153935521445 1.2579395565181717 0.2084136165746786 1.0 0.968531612291084 4 Q6IAN0,Q8WVX9,O15228 3 Sulfur amino acid metabolism 0.6163975687042413 1.2567095589542912 0.2088588254834895 1.0 0.968531612291084 9 Q9UBX3 1 Rac2 gtpase cycle 0.440427307764342 1.241863673940578 0.2142868648524065 1.0 0.9692998412784436 40 Q14739,P50402,P42167,Q8TAA9,P52735,Q7L576,O15173,O96013,Q9Y512,Q6IAA8,Q13505,Q86Y07,Q86XL3 13 Aflatoxin activation and detoxification 0.8569480235293487 1.2361073755701948 0.2164186536639978 1.0 0.9692998412784436 3 Q99735 1 Mitochondrial biogenesis 0.4480757663068417 1.222252360258164 0.2216122087126242 1.0 0.9692998412784436 35 Q9NVH1,Q5XKP0,Q9Y512,Q13505,Q16891,Q9BUR5,P24539,O75964,P56385,Q6UXV4,P56134,O75431,P54646 13 Ra biosynthesis pathway 0.846109175377451 1.1940260839502888 0.2324677649157771 1.0 0.9846918161656352 3 Q8NBN7,Q8TC12 2 Synthesis secretion and deacylation of ghrelin 0.842619036364242 1.1804974417294132 0.2378024273449848 1.0 0.997987587437351 3 P67812 1 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.842619036364242 1.1804974417294132 0.2378024273449848 1.0 0.997987587437351 3 P67812 1 Bbsome mediated cargo targeting to cilium 0.6141218791159184 1.1729957599706085 0.2407975060142153 1.0 0.9990538128234424 7 P78371,P49368 2 Metabolism of folate and pterines 0.5984499065452066 1.1686025604678694 0.2425637961641142 1.0 1.0 9 Q9H2D1 1 Peptide hormone metabolism 0.543914092999813 1.1623548203708198 0.2450913671454822 1.0 1.0 15 P67812,Q8NEW0 2 Processing of smdt1 0.5790467461828503 1.1524843226921464 0.2491221083036767 1.0 1.0 11 Q9H300,Q99623,Q10713 3 Phase i functionalization of compounds 0.5419660814686286 1.1511468720899631 0.2496718176248984 1.0 1.0 15 O43169,Q16850,Q6QHF9,P07099,P27338 5 Cargo concentration in the er 0.5495096556116734 1.1386458267569373 0.254850906318929 1.0 1.0 14 Q96PC5,Q13190,Q9HCU5,P49755,Q15363 5 Lipophagy 0.698323569850433 1.1316070971214809 0.2577996550016452 1.0 1.0 4 P54646 1 Translation of sars cov 1 structural proteins 0.6190319090297489 1.1145304279419206 0.2650516982440472 1.0 1.0 5 Q10472 1 Formation of atp by chemiosmotic coupling 0.5831032508231524 1.0931470804944856 0.2743292275607134 1.0 1.0 9 P56385,P24539,O75964 3 Gpvi mediated activation cascade 0.6012837471742623 1.0829532643288773 0.2788291678727765 1.0 1.0 6 P61586 1 Regulation of plk1 activity at g2 m transition 0.4260484346193872 1.0822428520405418 0.2791446319647668 1.0 1.0 38 O94927,P41208,P07437,Q9H6D7,P07900,P68371,P04350,Q13616,P63167,P43034,O43805 11 G2 m dna replication checkpoint 0.6860296253267671 1.0811780713366177 0.2796179104784511 1.0 1.0 4 P06493,O95067,Q99640 3 Proton coupled monocarboxylate transport 0.9230769230769232 1.0744023308461603 0.2826423982820987 1.0 1.0 2 P53985 1 Uptake and actions of bacterial toxins 0.591165246235354 1.065344272292797 0.2867201651833997 1.0 1.0 7 Q7L0J3,P13639 2 Rab geranylgeranylation 0.4739727535080707 1.0606678100879705 0.2888408938258822 1.0 1.0 20 Q9H0U4,P61026,P20339,Q15907,Q13637,Q15286,Q969Q5,P62820 8 Transport of small molecules 0.4752538031421734 1.0578903738239618 0.2901054242970997 1.0 1.0 157 Q6PIU2,P05141,Q8N4V1,Q9BUN8,Q9Y6M7,P35613,P09601,P30519,P16615,Q99623,P45880,Q9Y487,P20020,P21796,Q9BU23,Q9UBX3,P28288,P27105,P49721,O95202,P08183,Q93050,Q9H300,P12236,Q8NEW0,P30825,O15118,P05023,Q8TB61,P35610,P51790,Q4KMQ2,P55011,Q9H0U3,Q70HW3,P12235,Q9Y277,Q10713,P98194,O94905,O75477,P56589,P61289,Q9HD20,P23634,P07237,P53985,Q8WWC4,Q8WTV0,Q13438,Q99797 51 Plasma lipoprotein remodeling 0.9172714078374457 1.0529729334761466 0.2923533972829828 1.0 1.0 2 P07237 1 Negative regulators of ddx58 ifih1 signaling 0.5884030008727243 1.052397437785701 0.2926172437418073 1.0 1.0 7 Q15366 1 Rac3 gtpase cycle 0.416862262492041 1.0367259530292297 0.2998635931725946 1.0 1.0 40 Q14739,Q9UQB8,Q8TAA9,P50402,P42167,O15498,P52735,Q7L576,O15173,O96013,Q6IAA8,Q86Y07 12 Abc transporters in lipid homeostasis 0.8011033681765216 1.0207267910302766 0.307383897757048 1.0 1.0 3 P28288,P56589 2 Metabolism of lipids 0.5086693639244004 1.018010289068897 0.3086730664134116 1.0 1.0 195 Q14739,P38435,Q14534,Q9P035,Q15800,Q9NQZ5,Q8NF37,Q9BY49,Q9NP80,Q9UBM7,P23786,Q15165,Q53GQ0,Q8N2A8,O43681,Q8IVS2,P14324,Q8WVX9,P51648,O43772,P48651,Q53H12,Q8NCC3,Q16850,P07602,Q15392,P30536,Q6Y1H2,Q8N9F7,Q8IV08,Q9NZJ7,P50416,O15228,P27544,Q15738,O95470,P35610,P17900,P37268,Q06136,P20339,Q9H7Z7,P50897,Q9NPH0,Q99943,Q86UL3,Q15125,A0FGR8,Q10713,O95674,O43808,P54646,P04062,P42126,Q9UMR5,O75448,Q96G23,O60664,Q96N66,O75845,Q06520,P49327,O15269,Q9NTJ5,Q9HCL2,O76062,Q8NBQ5,Q9UBF8,Q6IAN0,Q13510,Q16880,Q9NZ01,O15270 73 Srp dependent cotranslational protein targeting to membrane 0.3960533761118144 1.012964428300274 0.3110771520775952 1.0 1.0 91 P27635,Q9Y3U8,Q07020,P62841,P36578,P25398,P61927,P04844,P15880,P43307,P46782,Q15629,P61313,P46778,Q9Y5M8,Q9UNL2,P39023,Q02543,P62266,P62917,P83881,P61619,P61513,P62829,Q15005,P51571,P04843,P84098,P67812,P62753 30 Caspase activation via extrinsic apoptotic signalling pathway 0.5956040496778839 1.0092052964887537 0.3128761870425425 1.0 1.0 5 P42574 1 Rhod gtpase cycle 0.4231646044194732 0.985042066408708 0.3246034083709088 1.0 1.0 32 Q14739,P50402,P42167,O15173,Q86Y07 5 Pyruvate metabolism 0.491633218402083 0.9697076602377706 0.3321922310929106 1.0 1.0 17 P35613,P21796,P53985 3 O linked glycosylation of mucins 0.7872912924116271 0.9682121964338116 0.3329384049644184 1.0 1.0 3 Q10472 1 Activation of gene expression by srebf srebp 0.4563738142123938 0.9417246784265222 0.3463336168160991 1.0 1.0 20 Q14534,Q16850,P37268,O75845,Q9UBM7,P49327,Q9HCL2,O76062,P14324 9 Acyl chain remodelling of pc 0.8859216255442706 0.9385296852676488 0.3479722688700506 1.0 1.0 2 Q8NF37 1 Pre notch processing in golgi 0.7721423394282092 0.9111134749235348 0.3622355872632585 1.0 1.0 3 P16615 1 Cytoprotection by hmox1 0.3552032818607921 0.8823645203919106 0.3775797157139025 1.0 1.0 68 P48556,P09601,P30519,Q15008,P28072,O75880,P49721,P53004,P09669,Q06323,O75832,Q13616,Q14997,O43819,P13073,Q8TCT9,P61289,O43242,P00403,P20674 20 Regulation of localization of foxo transcription factors 0.5544899738448082 0.8694764710663275 0.384586572090895 1.0 1.0 6 P31946,P61981,Q9Y3B8,P63104,P31751 5 Cytochrome p450 arranged by substrate type 0.7566153032394662 0.8532342723978755 0.3935294011079517 1.0 1.0 3 Q16850 1 Suppression of apoptosis 0.6279028589493658 0.8459015108943586 0.3976076895773044 1.0 1.0 4 P23246 1 Depolymerisation of the nuclear lamina 0.524870016117606 0.8384599857739009 0.4017724118295083 1.0 1.0 10 P42167 1 Prevention of phagosomal lysosomal fusion 0.6252046156390447 0.8351705507826565 0.4036216882350727 1.0 1.0 4 O14964,P20339 2 Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.7511614401858202 0.8330807800363262 0.4047991724583843 1.0 1.0 3 O00767,P49327 2 Small interfering rna sirna biogenesis 0.6225767986866877 0.8247413804265419 0.4095184332515429 1.0 1.0 4 Q99598 1 P75 ntr receptor mediated signalling 0.4386814813729184 0.8220191974416604 0.4110659710088904 1.0 1.0 20 Q9NQC3,P42574 2 Regulation of cholesterol biosynthesis by srebp srebf 0.4056023510385916 0.8161862556932354 0.4143936165316251 1.0 1.0 26 Q14534,Q16850,P37268,O75845,Q9UBM7,P49327,Q9HCL2,O76062,P14324 9 Platelet homeostasis 0.5052622334324011 0.807365094162824 0.419456171157303 1.0 1.0 12 P20020,P16615 2 G beta gamma signalling through pi3kgamma 0.7407084785133251 0.794740161965809 0.4267646650291825 1.0 1.0 3 P61586,P62873 2 Pi metabolism 0.4239735510795362 0.7915831644900851 0.4286037666288256 1.0 1.0 21 Q8IY17,P20339,Q9NTJ5,Q10713,Q01968,Q8N9F7,Q9UBF8 7 Stimuli sensing channels 0.517306506671059 0.7713514860256875 0.4404986225868188 1.0 1.0 9 Q4KMQ2,P27105 2 Cargo trafficking to the periciliary membrane 0.4063807602022747 0.740626515739543 0.4589199261422116 1.0 1.0 22 A6NIH7,O43924,Q10713,P78371,P49368 5 Cdc42 gtpase cycle 0.3827119898857102 0.7368716207456246 0.4612004236129168 1.0 1.0 40 Q14739,Q9UQB8,Q8TAA9,P42167,O15498,P52735,O96013,Q6IAA8,P27105 9 Sema4d induced cell migration and growth cone collapse 0.5157838861431917 0.7157619109401766 0.4741383750961216 1.0 1.0 7 P61586 1 Carnitine metabolism 0.5172364572198976 0.7026378420818615 0.4822814731970273 1.0 1.0 6 O43772,P50416,P54646 3 Rnd1 gtpase cycle 0.4614721487458343 0.6881863565881738 0.4913354344669871 1.0 1.0 15 Q8TAA9,P51648,O43396 3 Miro gtpase cycle 0.5837538505572468 0.6736782675874755 0.5005158814352435 1.0 1.0 4 Q8IWA4 1 Sars cov infections 0.3306718615912627 0.663440882768598 0.507048229617733 1.0 1.0 64 Q9H0U3,Q99873,Q96FZ7,P04843,P07437,Q16706,Q99720,P46977,P49356,P07900,Q10472,P21964,P49354,Q15185,P04844,P05023,P27824 17 Aryl hydrocarbon receptor signalling 0.7029616724738517 0.6600184241156826 0.5092420061508796 1.0 1.0 3 Q15185,O00170 2 Notch4 activation and transmission of signal to the nucleus 0.7991291727140766 0.6387494788452488 0.5229859190695811 1.0 1.0 2 Q92542 1 Ras activation upon ca2 influx through nmda receptor 0.5103792332560152 0.6363398532870627 0.5245549344376663 1.0 1.0 5 Q12959,Q13555 2 Negative regulation of nmda receptor mediated neuronal transmission 0.5103792332560152 0.6363398532870627 0.5245549344376663 1.0 1.0 5 Q12959,Q13555 2 Unblocking of nmda receptors glutamate binding and activation 0.5103792332560152 0.6363398532870627 0.5245549344376663 1.0 1.0 5 Q12959,Q13555 2 Long term potentiation 0.5103792332560152 0.6363398532870627 0.5245549344376663 1.0 1.0 5 Q12959,Q13555 2 Glycosaminoglycan metabolism 0.4658515933878299 0.6348873677370878 0.5255018763988932 1.0 1.0 13 Q8TB61,Q96L58,O43505,Q9P2E5,P54802,Q7LGA3 6 Sema4d in semaphorin signaling 0.4910478198651198 0.6236709544343217 0.5328437019828782 1.0 1.0 8 P61586 1 G protein beta gamma signalling 0.5048655394858746 0.6132530648408838 0.5397090223701373 1.0 1.0 5 P61586,P62873 2 Cardiac conduction 0.4573930201608481 0.5902111679970289 0.5550490857269916 1.0 1.0 13 P23634,P20020,P16615,P05023 4 Ion homeostasis 0.4573930201608481 0.5902111679970289 0.5550490857269916 1.0 1.0 13 P23634,P20020,P16615,P05023 4 Methionine salvage pathway 0.5597873198845899 0.5840458532938243 0.559189462731496 1.0 1.0 4 Q13126 1 Rnd2 gtpase cycle 0.4276061715032365 0.5801087089108978 0.5618413111793923 1.0 1.0 17 P51648,Q8TAA9,Q07065,O43396 4 Processing and activation of sumo 0.7776487663280114 0.5701950932162241 0.5685453837445835 1.0 1.0 2 Q9UBE0 1 Sumo is conjugated to e1 uba2 sae1 0.7776487663280114 0.5701950932162241 0.5685453837445835 1.0 1.0 2 Q9UBE0 1 Sumo is transferred from e1 to e2 ube2i ubc9 0.7776487663280114 0.5701950932162241 0.5685453837445835 1.0 1.0 2 Q9UBE0 1 Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.6764273155106488 0.5696782843562702 0.5688959212903841 1.0 1.0 3 P11802 1 Tp53 regulates metabolic genes 0.3667947666328642 0.5634291181003748 0.5731427140365493 1.0 1.0 37 P13073,P42345,Q9Y2Q5,P09669,Q6IAA8,O75880,Q9NQ88,P63104,P30044,Q9HCE1,P00403,O43819,Q7LG56,P10606,P20674,P54646 16 Ros and rns production in phagocytes 0.4727989559542381 0.560283590847394 0.5752860181312229 1.0 1.0 9 Q9Y487 1 Basigin interactions 0.4806187727421316 0.5588409109931083 0.5762702990121502 1.0 1.0 7 P53985 1 Rhoc gtpase cycle 0.3646752819188489 0.5555206067076006 0.5785386192235493 1.0 1.0 38 Q14739,Q13190,Q8TAA9,P42167,P49257,P52735,P61586,P63167,P27105,P28288 10 Class b 2 secretin family receptors 0.7727140783744537 0.5548540651769597 0.5789944832579008 1.0 1.0 2 Q9Y3E5 1 Antigen presentation folding assembly and peptide loading of class i mhc 0.4443860062420335 0.5547227916484795 0.5790842843104902 1.0 1.0 14 P51572,P27824,Q9NZ08 3 Glycerophospholipid catabolism 0.7677793904209151 0.5396757070512722 0.5894206961036157 1.0 1.0 2 Q8N9F7 1 Ion channel transport 0.3682573516645061 0.5309277671685002 0.5954688351449129 1.0 1.0 29 P51790,Q4KMQ2,Q9HD20,P16615,Q93050,Q9Y487,P98194,P20020,P05023,P27105 10 Rhobtb3 atpase cycle 0.5444892093022201 0.5287070233817113 0.597008704290237 1.0 1.0 4 O60664,Q15345 2 Rac1 gtpase cycle 0.3274128923862694 0.5182714441206887 0.6042688936760732 1.0 1.0 54 Q14739,Q9UQB8,Q8TAA9,P50402,P42167,O15498,P52735,Q7L576,O96013,Q6IAA8,Q86Y07,Q96F07 12 Beta oxidation of hexanoyl coa to butanoyl coa 0.480534572922715 0.5137904300528031 0.6073985194762148 1.0 1.0 5 P30084,P16219,P55084,P40939 4 G1 s specific transcription 0.4339492280135333 0.4988714312121453 0.6178699614106198 1.0 1.0 14 P00374,Q9Y619 2 Heme biosynthesis 0.4763480700058251 0.4971269499532398 0.619099531015868 1.0 1.0 5 P22830,P36551 2 Diseases of mitotic cell cycle 0.4387218584635997 0.4931232547318978 0.6219255003976061 1.0 1.0 13 P11802,Q9UJX3,Q00534,Q9UJX4,Q9H1A4 5 Interleukin 4 and interleukin 13 signaling 0.4319285379960361 0.4881498109375469 0.62544373129628 1.0 1.0 14 P09601 1 Hs gag degradation 0.7462989840348605 0.475621510441611 0.63434404795747 1.0 1.0 2 P54802 1 Mitotic g2 g2 m phases 0.3528919873647019 0.4744821857846271 0.6351560983808315 1.0 1.0 96 Q9BSJ2,Q9Y570,P48556,P28072,P43034,Q9BVA1,P49721,Q99640,O94927,P07437,P04350,Q13885,O75832,P07900,P68371,Q13616,Q14997,P63167,O43805,P61289,O43242,O75330,P41208,Q9BUF5,Q9H6D7,O75935 26 Role of phospholipids in phagocytosis 0.4678394784778017 0.4637234956558058 0.6428458613537822 1.0 1.0 5 Q8IV08 1 Cd28 dependent pi3k akt signaling 0.7404934687953529 0.4589073108266805 0.6463007285603253 1.0 1.0 2 P42345 1 Nef mediated downregulation of mhc class i complex cell surface expression 0.4532248692620523 0.4079332753982452 0.6833226623443658 1.0 1.0 5 P61966,O43747,Q9BXS5,P04439 4 Insulin receptor recycling 0.4351799835758448 0.4072926228157249 0.6837930804059145 1.0 1.0 10 Q9Y487 1 Peroxisomal lipid metabolism 0.4262740046134032 0.4054770805769579 0.6851268622328475 1.0 1.0 12 O43808,P51648 2 Golgi associated vesicle biogenesis 0.3516654311819689 0.4027753136964027 0.6871135232733907 1.0 1.0 29 O43493,Q9Y5X3,P55327 3 Pre notch expression and processing 0.4283811724530889 0.3945605018015395 0.693167268253919 1.0 1.0 11 Q15363,P16615 2 Ripk1 mediated regulated necrosis 0.4183760229292385 0.39045593909795 0.6961994302994492 1.0 1.0 13 P41440,Q16543,P49327 3 Smad2 smad3 smad4 heterotrimer regulates transcription 0.4482858803021453 0.3895727377355412 0.6968525146179929 1.0 1.0 5 P49336,Q13547,P28482,P27361 4 Mitotic prometaphase 0.3473056703400523 0.3892653712237768 0.6970798498972524 1.0 1.0 98 Q7Z5K2,Q6P1K2,P43034,Q9BVA1,O94927,P07437,Q8NFH4,P04350,Q13885,Q96EE3,P07900,P68371,P63167,Q7L7X3,O43805,Q15005,P41208,Q92674,Q9BUF5,Q8NBT2,Q9H6D7,O75935 22 Abc family proteins mediated transport 0.3144937304140013 0.3846239385225863 0.7005160556766197 1.0 1.0 54 P61289,P49721,O43242,O75027,P56589,Q9BUN8,P48556,P08183,Q15008,P40855,P28072,Q14997,Q13438,O94905,O75477,Q06323,O75832,P28288 18 Mtor signalling 0.4162294674129879 0.3798573137882092 0.7040513351048938 1.0 1.0 13 P42345,Q9Y2Q5,Q6IAA8,P54646,P62753 5 Piwi interacting rna pirna biogenesis 0.4249069091312121 0.3785425302318616 0.7050276055372742 1.0 1.0 11 Q9Y2W6 1 Raf independent mapk1 3 activation 0.4341378307647535 0.3743629797035691 0.7081342816975957 1.0 1.0 8 P06493,Q02750,P29597,P28482,P27361,Q99956,P23458 7 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.4311574908491674 0.3742318172672826 0.7082318542181625 1.0 1.0 9 Q9UJX3,Q9UJX4,Q9H1A4 3 Death receptor signalling 0.347625962745656 0.3720029688819941 0.7098906388879564 1.0 1.0 29 Q9NQC3,P42574,P52735,P49327,P61586,P63244 6 Dap12 interactions 0.4432647271844411 0.3711813540534681 0.7105024600143666 1.0 1.0 5 P10321 1 Mtorc1 mediated signalling 0.4300272752102502 0.3574621425555795 0.7207458623875531 1.0 1.0 8 Q6IAA8,P62753,Q9Y2Q5 3 Mapk3 erk1 activation 0.4338854984016351 0.355842771763603 0.7219583155790978 1.0 1.0 6 P06493,Q02750,P29597,P27361,P23458 5 Attachment of gpi anchor to upar 0.6063310443832579 0.355358060522415 0.7223213639742869 1.0 1.0 3 Q92643 1 Synthesis of pe 0.6036654048529063 0.3480613648326046 0.7277940987079989 1.0 1.0 3 P35790 1 P75ntr negatively regulates cell cycle via sc1 0.6986937590711144 0.3469925024272552 0.7285969514481494 1.0 1.0 2 Q13547 1 Cobalamin cbl vitamin b12 transport and metabolism 0.4859134475748102 0.3347709430667524 0.7377978810749424 1.0 1.0 4 Q99707,P33527,P22033 3 Nuclear envelope breakdown 0.3336540381261796 0.3341424915973364 0.7382720372702518 1.0 1.0 42 Q9BTX1,Q86Y07,P42167,Q8NFH4 4 Rnd3 gtpase cycle 0.3847620054873915 0.3312645943572249 0.7404446325170475 1.0 1.0 17 P12277,Q8TAA9,Q07065,O43396 4 The phototransduction cascade 0.4233436944442477 0.3221893400289805 0.7473092597038429 1.0 1.0 7 P49354,P49356,P50579 3 Beta oxidation of lauroyl coa to decanoyl coa coa 0.4803950043566735 0.3182791976291497 0.7502731623897991 1.0 1.0 4 P30084,P40939,P55084 3 Beta oxidation of butanoyl coa to acetyl coa 0.4803950043566731 0.3182791976291485 0.7502731623898 1.0 1.0 4 P30084,P40939,P16219 3 Apc c cdc20 mediated degradation of cyclin b 0.4113983798005713 0.3175400656067085 0.7508338432769501 1.0 1.0 11 P06493,Q9UJX3,Q9UJX4,P30260,Q9H1A4,Q9UJX2 6 Transferrin endocytosis and recycling 0.4113351209847958 0.3172595080930651 0.7510466993184548 1.0 1.0 11 Q9Y487 1 Folding of actin by cct tric 0.4198369077681815 0.3163893036407649 0.7517070347619177 1.0 1.0 8 P78371,P49368 2 Receptor type tyrosine protein phosphatases 0.6859216255442638 0.3160124859845996 0.7519930309661689 1.0 1.0 2 Q13136 1 Activation of kainate receptors upon glutamate binding 0.590357591629814 0.3127145489097528 0.7544975411313419 1.0 1.0 3 Q12959 1 Diseases of glycosylation 0.3613272414169908 0.3121727875737347 0.7549092117986151 1.0 1.0 20 Q9BT22,Q9H3H5,O75352,Q2TAA5 4 Camk iv mediated phosphorylation of creb 0.6777939042089951 0.29714248931575 0.7663577266874744 1.0 1.0 2 Q13555 1 Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0.6777939042089951 0.29714248931575 0.7663577266874744 1.0 1.0 2 Q13555 1 Cellular response to chemical stress 0.3148511308896484 0.2955587759296104 0.7675670597712507 1.0 1.0 78 P61289,P49721,O43819,P09601,P30519,P07237,P00403,P13073,Q8TCT9 9 G alpha i signalling events 0.3359722400993931 0.2918109237382456 0.7704311926492946 1.0 1.0 25 P07602 1 Metabolism of fat soluble vitamins 0.4173661719574306 0.2811666142965161 0.7785826100896394 1.0 1.0 5 Q6NUM9,Q8N0U8 2 Slc transporter disorders 0.3346795912662557 0.2770017792129278 0.7817787399701097 1.0 1.0 32 Q9BTX1,P53985,Q8NFH4 3 Traf6 mediated irf7 activation 0.5743321718931504 0.272647473856695 0.7851242150890734 1.0 1.0 3 Q12933,Q14258 2 Chaperone mediated autophagy 0.410928907210168 0.2715284794324626 0.78598459873614 1.0 1.0 6 O60664,P08670,P07900 3 Gap junction degradation 0.4058686809994144 0.244090529528379 0.8071607070967735 1.0 1.0 5 P50570,Q00610,Q9UM54,Q96CW1 4 Signaling by retinoic acid 0.3868247692440045 0.240326273117484 0.8100773287490415 1.0 1.0 13 Q8NBN7,Q8TC12,P50416 3 Glycogen breakdown glycogenolysis 0.400464981110151 0.2353614908259044 0.8139281724608944 1.0 1.0 6 P11216,P10253,P35573,Q96G03,P06737 5 Activation of the ap 1 family of transcription factors 0.5528455284552878 0.2234704486756262 0.8231693801416582 1.0 1.0 3 Q16539,P27361 2 Negative feedback regulation of mapk pathway 0.5528455284552878 0.2234704486756262 0.8231693801416582 1.0 1.0 3 Q02750,P27361 2 Interleukin 12 signaling 0.3270393743850787 0.218283485325376 0.8272082410280359 1.0 1.0 30 Q13126,P14174,P07237,Q00169,O00170,O14979 6 Cooperation of pdcl phlp1 and tric cct in g protein beta folding 0.3881666452226254 0.2181681033482537 0.8272981363192979 1.0 1.0 11 P50991,Q99832,P62873,P78371,P49368,P17987 6 Metabolism of cofactors 0.394661745907126 0.2159773631621527 0.8290053927273542 1.0 1.0 6 P00374,Q9Y2Z9 2 Platelet activation signaling and aggregation 0.283873665219827 0.2127280067057732 0.8315391205201421 1.0 1.0 59 O94919,Q8NBX0,P07602,P52735,Q9UEU0,P61586,O43852,Q8NBM8,Q8NCG7,Q6UXV4,Q8N2K0,Q92520,Q9NZJ7 13 Interleukin 12 family signaling 0.3253977313503995 0.2086550701902907 0.834717516836395 1.0 1.0 33 Q13126,P14174,P07237,Q00169,O00170,O14979,P27824 7 Phosphorylation of the apc c 0.3803480809276499 0.1973027948240247 0.8435905923823777 1.0 1.0 12 P06493,Q9UJX3,Q9UJX4,P30260,Q9H1A4,Q9UJX2 6 Mapk1 erk2 activation 0.4336334591925682 0.1937254215105323 0.8463908854285691 1.0 1.0 4 P23458,P29597,P28482 3 Interleukin 10 signaling 0.53803716608595 0.1927529184091383 0.8471524775857449 1.0 1.0 3 P23458,P29597 2 Synthesis of pips at the late endosome membrane 0.4327621260528671 0.1916826452391492 0.8479908009963115 1.0 1.0 4 Q99570,O00443,Q08AM6 3 Signaling by insulin receptor 0.3636211889573273 0.1906554218656755 0.8487955661437394 1.0 1.0 16 Q9Y487 1 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3823515094727976 0.1862640921734576 0.8522376649546373 1.0 1.0 10 Q9UJX3,Q9UJX4,Q9H1A4 3 Maturation of sars cov 2 nucleoprotein 0.4277060795424005 0.1800420459403187 0.8571195596124923 1.0 1.0 4 Q99873 1 Uptake and function of anthrax toxins 0.6162554426705326 0.1769863345588165 0.8595191235694701 1.0 1.0 2 Q02750 1 Degradation of the extracellular matrix 0.3791688045907964 0.1691641807675734 0.865667503304623 1.0 1.0 9 P42574 1 Interleukin 7 signaling 0.520325203252036 0.1595225153062523 0.8732572207989984 1.0 1.0 3 P23458,P40763 2 Cyclin a b1 b2 associated events during g2 m transition 0.3708876347489242 0.1583349143497187 0.8741928974609816 1.0 1.0 12 Q9Y570 1 Diseases of mismatch repair mmr 0.5177119628339176 0.1549468869744782 0.8768631895197765 1.0 1.0 3 P52701,P20585 2 G alpha s signalling events 0.3748910200523166 0.1538430492097923 0.8777334895012183 1.0 1.0 6 P62873,P63096,P08754,P32121,Q9Y3E5 5 Copii mediated vesicle transport 0.3178215821044742 0.151375031372548 0.8796798845589624 1.0 1.0 32 Q13190,O15498,Q9HCU5,P49755,Q15363 5 Interactions of vpr with host cellular proteins 0.3176189355476063 0.1508397083915098 0.8801021618494391 1.0 1.0 33 P12235,Q9BTX1,Q8NFH4,P12236 4 Unwinding of dna 0.3711026010418974 0.1445644949662569 0.8850547315999973 1.0 1.0 10 P25205,Q14566 2 Tp53 regulates transcription of cell death genes 0.3709342650623407 0.1440196363578606 0.8854849637135489 1.0 1.0 5 P49327,Q13315 2 Cd163 mediating an anti inflammatory response 0.5785195936139282 0.1237692027746016 0.9014980169061022 1.0 1.0 2 Q16539 1 Glucose metabolism 0.2777829336358612 0.1217630299396894 0.9030866938631076 1.0 1.0 61 Q9BTX1,Q9BRR6,Q9UBX3 3 Traf3 dependent irf activation pathway 0.57416545718432 0.1186083761093983 0.9055856290254304 1.0 1.0 2 Q14258 1 N glycan trimming in the er and calnexin calreticulin cycle 0.3539254872086667 0.111000038403229 0.911616316279642 1.0 1.0 14 Q13438,Q9BUN8 2 Potential therapeutics for sars 0.3075743116534936 0.1082603305258834 0.9137891892693872 1.0 1.0 41 P21964,P05023,P07437,Q99720 4 Defects in cobalamin b12 metabolism 0.4857723577235812 0.1058090437451496 0.9157338612027216 1.0 1.0 3 Q99707,P22033 2 Association of tric cct with target proteins during biosynthesis 0.3320979746769076 0.1055352460591609 0.9159511038251174 1.0 1.0 19 P04062,P78371,P49368 3 Arachidonic acid metabolism 0.3599517295203132 0.1047583986752735 0.916567521396378 1.0 1.0 8 Q15165 1 Mastl facilitates mitotic progression 0.3538640325392161 0.1026732901744549 0.9182222729395988 1.0 1.0 5 P06493,P30153,P14635,Q96GX5 4 Il 6 type cytokine receptor ligand interactions 0.5564586357039134 0.099611455769093 0.9206527986754484 1.0 1.0 2 P29597 1 Regulation of hmox1 expression and activity 0.2973878716270385 0.0983489074043857 0.9216552438936574 1.0 1.0 48 P61289,P49721,O43242,P48556,P09601,Q15008,Q13616,P28072,Q14997,Q8TCT9,Q06323,O75832 12 Receptor mediated mitophagy 0.4785133565621406 0.0963650284588802 0.9232306660733351 1.0 1.0 3 P67870,Q96HS1 2 Signaling by mapk mutants 0.5526850507982531 0.0959640237234217 0.923549145560693 1.0 1.0 2 Q99956 1 Signaling by activin 0.552685050798253 0.0959640237234214 0.9235491455606932 1.0 1.0 2 P27361 1 Signaling by nodal 0.552685050798253 0.0959640237234214 0.9235491455606932 1.0 1.0 2 P27361 1 Rho gtpases activate cit 0.3570845315509456 0.0958421374105717 0.9236459505654232 1.0 1.0 10 P61586 1 Ngf stimulated transcription 0.4776422764227682 0.095273616085901 0.9240974986211938 1.0 1.0 3 P50570,Q14839 2 Platelet sensitization by ldl 0.3539668700959103 0.0952403041739426 0.9241239573668578 1.0 1.0 6 Q14738,Q06124,Q13362,P30153,Q16539 5 Golgi cisternae pericentriolar stack reorganization 0.3547692436817996 0.0907415474002942 0.9276979567398732 1.0 1.0 11 P06493,Q9H0U4,P27361,P61019,O95067,P62820 6 Mrna decay by 3 to 5 exoribonuclease 0.3414435925738489 0.0855042284890864 0.9318605339364964 1.0 1.0 16 Q969T7,Q9Y3B2 2 Synthesis of udp n acetyl glucosamine 0.3439860546194018 0.0811488627270051 0.9353235669526055 1.0 1.0 5 Q96EK6,Q16222,Q06210,Q9UJ70 4 Gaba receptor activation 0.3746732500726086 0.0805203568318589 0.9358234063899946 1.0 1.0 4 P62873,P63096,P08754 3 Gaba b receptor activation 0.3746732500726086 0.0805203568318589 0.9358234063899946 1.0 1.0 4 P62873,P63096,P08754 3 Adp signalling through p2y purinoceptor 12 0.3746732500726086 0.0805203568318589 0.9358234063899946 1.0 1.0 4 P62873,P63096,P08754 3 Gene silencing by rna 0.2931253388259165 0.0758383595900945 0.9395476974471356 1.0 1.0 49 Q9BTX1,O15397,Q9NRG9,P30876,Q9Y2W6,Q99598,Q8NFH4,P07900,P62875,Q8NFH5,Q96EE3,Q8N2A8,P84243 13 Nef mediated cd4 down regulation 0.3443766346992243 0.0710227297535485 0.9433796654409484 1.0 1.0 6 P63010,Q96CW1,Q9UI12,P53680,O95782 5 Nef mediated cd8 down regulation 0.3443766346992243 0.0710227297535485 0.9433796654409484 1.0 1.0 6 P63010,Q96CW1,Q9UI12,P53680,O95782 5 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.3387378180338923 0.0704395728558943 0.9438437948706768 1.0 1.0 5 P78310 1 The role of nef in hiv 1 replication and disease pathogenesis 0.3450786255096096 0.0662284544126162 0.9471959431546312 1.0 1.0 13 P63010,P63000,O43747,Q9BXS5,Q96CW1,P61966,Q13177,Q9UI12,P53680,O95782,P04439,Q10567 12 Downregulation of erbb4 signaling 0.514078374455727 0.0660546869936178 0.9473342865580988 1.0 1.0 2 P46934 1 Regulated necrosis 0.3134913202259585 0.064097684417582 0.9488924456236284 1.0 1.0 21 P42574,Q96FZ7,Q16543,P49327,P41440 5 Uptake and function of diphtheria toxin 0.3615781605773672 0.0623184017167291 0.9503092745070474 1.0 1.0 4 P07900,P13639 2 Acyl chain remodeling of cl 0.5047895500725629 0.060684726007168 0.9516102961408316 1.0 1.0 2 P40939 1 Retrograde neurotrophin signalling 0.3445769118929853 0.0604326597231658 0.9518110474856464 1.0 1.0 8 P50570,P63010,P09496,Q96CW1,P53680,Q00610,O95782 7 Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.3448777648428389 0.0571590036270693 0.9544185351055092 1.0 1.0 11 P63010,O43747,Q9BXS5,Q96CW1,P61966,Q9UI12,P53680,O95782,P04439,Q10567 10 Downregulation of erbb2 erbb3 signaling 0.4955007256893988 0.0559353392537508 0.9553933182345782 1.0 1.0 2 P31751 1 Phosphorylation of emi1 0.4384436701509914 0.0549849837234476 0.9561504269465636 1.0 1.0 3 P06493,P14635 2 Pentose phosphate pathway 0.3419598720558293 0.0533523490969632 0.95745117101313 1.0 1.0 8 O95336,P49247,P52209,P37837,Q9Y315,Q96G03,P29401 7 Runx2 regulates genes involved in cell migration 0.4885341074020257 0.0527533999453214 0.957928391220232 1.0 1.0 2 P31751 1 Nef and signal transduction 0.487663280116104 0.0523774581554199 0.9582279352437 1.0 1.0 2 Q13177 1 Wnt mediated activation of dvl 0.4783744557329416 0.0486535040294423 0.961195430369422 1.0 1.0 2 P67870 1 Inla mediated entry of listeria monocytogenes into host cells 0.4647314949201675 0.0440620492927959 0.9648549436644424 1.0 1.0 2 P35222 1 Rho gtpases activate rocks 0.3401935537730863 0.0423488948929166 0.9662205677345368 1.0 1.0 10 P61586 1 Activation of smo 0.417537746806044 0.0399345348786548 0.9681453182020512 1.0 1.0 3 P48729,Q9Y496 2 Activated notch1 transmits signal to the nucleus 0.4175377468060439 0.0399345348786545 0.9681453182020514 1.0 1.0 3 Q92542,Q96J02 2 Activation of irf3 irf7 mediated by tbk1 ikk epsilon 0.4333817126269903 0.0367696515318326 0.9706686722469402 1.0 1.0 2 Q6SZW1 1 Free fatty acids regulate insulin secretion 0.4217706821480347 0.0349789236784972 0.9720965470552714 1.0 1.0 2 O95573 1 Condensation of prometaphase chromosomes 0.3375036368926302 0.0343869303604198 0.9725686053708203 1.0 1.0 10 P06493,P19784,O95347,Q15003,Q9NTJ3,Q15021,O95067,P14635,P67870 9 Synthesis of ip3 and ip4 in the cytosol 0.3901306240928824 0.0318347463229786 0.9746038371123458 1.0 1.0 2 Q01968 1 Thrombin signalling through proteinase activated receptors pars 0.3166763509587404 0.0309404688263098 0.9753170159042972 1.0 1.0 5 P62873,P32121,P28482,P27361 4 Dopamine neurotransmitter release cycle 0.3570391872278603 0.0303121686010567 0.975818091892751 1.0 1.0 2 Q13136 1 Mrna editing 0.3274310595065248 0.0297494793704296 0.9762668505342724 1.0 1.0 2 Q9NRW3 1 Traf6 mediated induction of tak1 complex within tlr4 complex 0.3158200290275697 0.0296387520798872 0.9763551591885684 1.0 1.0 2 Q6SZW1 1 Regulation of bach1 activity 0.3290734824281127 0.0273382362328142 0.9781899601523012 1.0 1.0 4 P63208,O14867,Q13616 3 Activation of bad and translocation to mitochondria 0.3291654550741321 0.0207478621367459 0.9834467887605216 1.0 1.0 8 P27348,P31946,P61981,Q9Y3B8,P63104,P62258,P31751 7 Adrenaline noradrenaline inhibits insulin secretion 0.3745644599303177 0.0201594353815823 0.983916187179765 1.0 1.0 3 P62873,P63096 2 Rhoj gtpase cycle 0.2965089624050931 0.0200386550426658 0.9840125364842188 1.0 1.0 26 Q8TAA9,P42167,Q9Y6M7,O96013,P27105 5 Clec7a dectin 1 induces nfat activation 0.370209059233454 0.0188326486846181 0.9849746085533346 1.0 1.0 3 O43865,Q08209 2 Caspase activation via death receptors in the presence of ligand 0.3142608190531575 0.0157811842045163 0.9874089593984434 1.0 1.0 4 Q12933,P49327,Q13546 3 Regulation by c flip 0.3142608190531575 0.0157811842045163 0.9874089593984434 1.0 1.0 4 Q12933,P49327,Q13546 3 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.3292611983711513 0.0152143185958608 0.9878611983968756 1.0 1.0 9 P06493,P27348,P31946,P61981,Q9Y3B8,P63104,P14635,P62258 8 Signaling by alk 0.3053457292271886 0.0140641482784141 0.9887788031549856 1.0 1.0 5 P40763,Q13547,P19174,Q92769 4 Displacement of dna glycosylase by apex1 0.3426248548199812 0.0125805874720968 0.9899624082677988 1.0 1.0 3 P29372,P27695 2 Hemostasis 0.3477024921522973 0.0117721471498791 0.9906074024852054 1.0 1.0 132 Q8IWA4,Q8NBX0,P35613,P16615,P20020,Q92520,Q9BVA1,P07602,P04350,Q13885,O95140,Q9NZJ7,O94919,P14174,P68371,Q8NBM8,Q6UXV4,Q8NCG7,Q8N2K0,P78310,P42785,P23634,Q9BUF5,P53985,P61586 25 Glycogen storage diseases 0.3283972125435582 0.0105245664183134 0.9916027659680045 1.0 1.0 3 P13807,P10253 2 Stat3 nuclear events downstream of alk signaling 0.3052570432762146 0.0099386058338484 0.9920702703938264 1.0 1.0 4 P40763,Q13547,Q92769 3 Gdp fucose biosynthesis 0.3193960511033724 0.0095348781880646 0.9923923831778036 1.0 1.0 3 Q13630,O14772 2 Josephin domain dubs 0.3086527293844408 0.0086103709500199 0.993130002844832 1.0 1.0 3 P54727,P54725 2 Vitamin c ascorbate metabolism 0.3083623693379838 0.0085887849510246 0.9931472253433222 1.0 1.0 3 P11166,P00387 2 G beta gamma signalling through cdc42 0.2636469221835124 0.0067252255204758 0.9946340868381676 1.0 1.0 3 P62873,P60953 2 Epha mediated growth cone collapse 0.3282914914075729 0.00565132235974 0.9954909211424654 1.0 1.0 11 P61586 1 Nr1h2 and nr1h3 mediated signaling 0.3232243845824972 6.389418580060841e-05 0.9999490198156592 1.0 1.0 9 O00767,Q8NB78,Q9HCE1,P49327 4