Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Respiratory electron transport 0.5727997750444932 3.3837781055736373 0.000714957592101 0.6357377392404578 0.6516528709376437 57 O75380,Q9Y6M9,Q96I36,P47985,O43676,Q9Y6N1,Q9UDW1,Q9P0J0,O96000,O43674,P15954,O14949,Q9Y375,P20674,P00403,Q9NX14,Q86Y39,Q9NPL8,O95168,O75880,P03886,P51970,P22695,P08574,P13073,Q8TB37,Q16134,P21912,O43819 29 Protein localization 0.5845014234197816 3.267376740136977 0.0010854912325415 0.7842308292027544 0.6516528709376437 74 Q9NS69,P50402,Q99595,Q9NX63,O60830,Q9Y3D6,P21796,P09601,Q9Y5J9,Q13505,Q9Y512,Q3ZCQ8,Q10713,P05067,O96008,Q15388,P46379,P56589,Q9NR77,O43808,P06576,Q9Y5J6,Q8N4H5,O15254,O75431,Q13011,O43681,O14925,P51648,P12236,O00116,Q8TB36,Q9UJS0,O43615,P40855,Q9BY49 36 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.5658256682837235 3.197856498211142 0.0013845315954765 0.8586213057835077 0.6516528709376437 66 O75380,Q9Y6M9,Q96I36,P47985,O43676,Q9Y6N1,Q9UDW1,Q9P0J0,P24539,O75964,O96000,O43674,P15954,O14949,P06576,Q9Y375,P56385,P20674,P00403,Q9NX14,Q86Y39,Q9NPL8,O95168,O75880,P03886,P51970,P22695,P08574,P13073,Q16134,P21912,O43819 32 Sphingolipid metabolism 0.8024047732955885 2.5501369192454875 0.0107680620207037 0.999999770406972 0.8922760896931355 29 P07686,Q06136,Q96G23,P07602,Q13510,P06280,O15121,P16278,Q9NRA0,P10619,P06865,P51648,Q8N5B7,O15269,P17900,P04062,O95470,Q9NZJ7,Q16739 19 Phospholipid metabolism 0.5032917207337294 2.4363787251345435 0.0148351430858804 0.9999999993167454 0.8922760896931355 54 Q9UG56,Q53H12,Q9NPH0,Q92604,Q8N2A8,Q9HBU6,Q8NCC3,P35790,Q8WWI5,Q8IV08,Q9HCL2,Q9BVG9,Q10713,Q96N66,Q9NQZ5 15 Heme degradation 0.9357465172682676 2.3965043400907495 0.0165522974596559 0.9999999999418172 0.8922760896931355 4 P30519 1 Rhoa gtpase cycle 0.4660119231497583 2.3550257076865506 0.0185214242932367 0.9999999999965666 0.8922760896931355 56 P30519,Q14254,P42167,Q86UP2,P41440,Q96HY6,P27105,Q07021,Q8IWB9,Q15904,O15173,O75955,P42166,Q14739,Q9H0H5,Q8TAA9,P28288,P49257,Q5T8D3,Q9P0I2,O75962,Q8NBN3,P51572 23 Peptide ligand binding receptors 0.8527295877817498 2.303313035486527 0.0212612367329765 0.9999999999999336 0.8922760896931355 8 Q9NZJ7,P22466,P07602,P42892 4 Class a 1 rhodopsin like receptors 0.8527295877817498 2.303313035486527 0.0212612367329765 0.9999999999999336 0.8922760896931355 8 Q9NZJ7,P22466,P07602,P42892 4 Keratan sulfate keratin metabolism 0.8928571428571389 2.2839665057163043 0.0223734994877367 0.9999999999999868 0.8922760896931355 5 O43505,P06865,P16278,P15586 4 Heparan sulfate heparin hs gag metabolism 0.8500117813316206 2.280249021886578 0.0225929233879127 0.9999999999999905 0.8922760896931355 6 P16278,P08236,Q7LGA3,P54802 4 Glycosphingolipid metabolism 0.8229472689215862 2.267640432063484 0.0233511312379761 0.9999999999999968 0.8922760896931355 16 Q13510,P07686,P06865,P17900,P04062,Q9NZJ7,P06280,P16278,Q16739,P10619,P07602 11 Mucopolysaccharidoses 0.8790776152980816 2.227476990313146 0.0259154119459359 1.0 0.8922760896931355 5 P16278,P08236,P54802,P15586 4 Transport of connexons to the plasma membrane 0.8371308016877657 2.225492619504012 0.0260481860440275 1.0 0.8922760896931355 6 Q13885,P68371,Q9BUF5,P04350,Q9BVA1 5 Gap junction assembly 0.8371308016877657 2.225492619504012 0.0260481860440275 1.0 0.8922760896931355 6 Q13885,P68371,Q9BUF5,P04350,Q9BVA1 5 Keratan sulfate degradation 0.8926061287601871 2.2217342782870713 0.0263012685527845 1.0 0.8922760896931355 4 P16278,P06865,P15586 3 Hs gag degradation 0.8788304751194764 2.16523601104723 0.0303696158832187 1.0 0.8922760896931355 4 P16278,P08236,P54802 3 Glycosaminoglycan metabolism 0.7913648532323687 2.13586198420452 0.0326906650347129 1.0 0.8922760896931355 17 P07686,P06865,P54802,O43505,P16278,Q7LGA3,Q8N6G5,P08236,P15586,Q8NCH0,Q8TB61 11 Sphingolipid de novo biosynthesis 0.8037257574885565 2.133585225587475 0.032876748448092 1.0 0.8922760896931355 13 O15269,P51648,O95470,Q06136,O15121,Q96G23,Q9NRA0 7 Chondroitin sulfate dermatan sulfate metabolism 0.8542910499870142 2.1249708590767513 0.0335890445482442 1.0 0.8922760896931355 5 P06865,Q8N6G5,Q8NCH0 3 Activation of ampk downstream of nmdars 0.8081355294804886 2.109381286571539 0.0349116834530789 1.0 0.8922760896931355 8 Q13885,P68371,Q9BUF5,P04350,Q9BVA1 5 Incretin synthesis secretion and inactivation 0.864644474985234 2.106710519632601 0.0351426797914757 1.0 0.8922760896931355 4 P67812 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.864644474985234 2.106710519632601 0.0351426797914757 1.0 0.8922760896931355 4 P67812 1 Gpcr ligand binding 0.7939627665020358 2.067731013247004 0.0386653239205982 1.0 0.8922760896931355 11 Q9NZJ7,P22466,P07602,P42892 4 Mitochondrial protein import 0.6852919434049083 2.06415786558682 0.0390027509765269 1.0 0.8922760896931355 33 Q9NS69,Q99595,Q9NX63,O60830,P21796,Q9Y5J9,Q13505,Q9Y512,Q3ZCQ8,Q10713,O96008,Q15388,P06576,Q9Y5J6,Q8N4H5,O75431,O14925,P12236,Q9UJS0,O43615 20 Rac2 gtpase cycle 0.6134624313805948 2.0555095537050656 0.0398298138519652 1.0 0.8922760896931355 41 P50402,Q86XL3,O15173,Q14739,Q13505,Q9Y512,Q86Y07,Q9H0H5,O75962,Q8TAA9,Q14185,P42167 12 Synthesis of very long chain fatty acyl coas 0.7936497234483334 2.0510760101893655 0.040259545135393 1.0 0.8922760896931355 9 Q6Y1H2,Q9P035,Q9UKU0,Q53GQ0,Q9NZ01 5 Metabolism of steroid hormones 0.794663270000217 2.045587050949518 0.0407970165477244 1.0 0.8922760896931355 7 O95772,Q14849,P30536 3 Pre notch processing in golgi 0.8482108230058535 2.038481732957575 0.0415017797633761 1.0 0.8922760896931355 4 Q15363,P16615 2 Pregnenolone biosynthesis 0.8301253541814768 2.0239394421560144 0.0429763830216507 1.0 0.8922760896931355 5 O95772,Q14849 2 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.7879141289884393 2.013054169761951 0.0441089309140503 1.0 0.8922760896931355 6 Q5KU26,P01889,P10321 3 Metabolism of porphyrins 0.7832257604424957 2.004411688742175 0.0450259782376651 1.0 0.8922760896931355 9 P30519,P09601 2 Endosomal vacuolar pathway 0.8324430700028045 1.9725919528525613 0.0485420705737742 1.0 0.8922760896931355 4 Q9UIQ6,P01889,P10321 3 Mitochondrial calcium ion transport 0.7586144851893615 1.961608096651655 0.0498081289010465 1.0 0.8922760896931355 16 O95202,P45880,Q8IYU8,P21796,Q9BPX6,Q10713 6 Class i peroxisomal membrane protein import 0.7636016257881708 1.9288176171248388 0.0537535079788649 1.0 0.8922760896931355 11 P51648,P56589,Q9NR77,Q9Y3D6,O43808,Q8TB36,O75381,P40855,P28288 9 Transport of bile salts and organic acids metal ions and amine compounds 0.8183862805735085 1.9135094951558 0.0556828591222817 1.0 0.8922760896931355 4 P53985,Q8WWI5,P35613 3 Striated muscle contraction 0.7546468541265858 1.866614315627514 0.0619554669989883 1.0 0.8922760896931355 6 Q9NYL9,P67936,P09493,P08670 4 Synthesis of pg 0.9372781724088668 1.8512960906401936 0.0641269682040719 1.0 0.8922760896931355 3 Q8IV08 1 Basigin interactions 0.7458475984094212 1.8313857241487328 0.0670429905832736 1.0 0.8922760896931355 8 P53985,P35613 2 Diseases associated with glycosaminoglycan metabolism 0.7787358634012003 1.805629239248975 0.0709762722918827 1.0 0.8922760896931355 5 P06865,Q8NCH0 2 Integrin cell surface interactions 0.7767286256244337 1.7970107618580171 0.0723339112824605 1.0 0.8922760896931355 5 P35613 1 Ecm proteoglycans 0.7892090793434395 1.7898894816761903 0.0734716801047716 1.0 0.8922760896931355 4 P05067 1 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.731412506399726 1.7793601898427835 0.0751807288212302 1.0 0.8922760896931355 11 P51648,P50402,P46379,P09601,P05067 5 Synthesis of pa 0.7331885992773732 1.777215117752472 0.0755328530413554 1.0 0.8922760896931355 9 Q9NPH0,Q86UL3,Q8N2A8,Q8NF37,Q9HCL2,O15228,Q9NUQ2 7 Assembly and cell surface presentation of nmda receptors 0.725732619894821 1.7679279042478462 0.0770729571647073 1.0 0.8922760896931355 13 P07196,Q13885,P68371,Q13555,Q13509,Q12959,Q9BUF5,Q14168,P04350,Q9BVA1 10 Amino acid transport across the plasma membrane 0.7663104611923199 1.7521735191764307 0.0797439755872908 1.0 0.8922760896931355 5 P08195,Q9H2J7,Q96QD8,P30825 4 Stimuli sensing channels 0.7244274250947433 1.7466425961574212 0.0806993535066877 1.0 0.8922760896931355 11 P51798,P27105,Q9C0H2,P51790 4 O linked glycosylation 0.7641898676584984 1.743025810940587 0.0813291063381229 1.0 0.8922760896931355 5 O43505,Q10472,Q8N4A0 3 O linked glycosylation of mucins 0.7641898676584984 1.743025810940587 0.0813291063381229 1.0 0.8922760896931355 5 O43505,Q10472,Q8N4A0 3 Copi dependent golgi to er retrograde traffic 0.4899198372670748 1.7367164193792264 0.0824372381094695 1.0 0.8922760896931355 49 Q9BVA1,Q12981,Q15363,Q13885,P68371,Q9P2W9,Q9Y3B3,Q9BVK6,Q9BUF5,P24390,Q9H0H5,P04350,Q6NUQ1,O15260 14 Egr2 and sox10 mediated initiation of schwann cell myelination 0.7215840384564454 1.7209486174107518 0.0852601482641008 1.0 0.8922760896931355 8 Q9NR77,Q16850 2 Synthesis of pe 0.8996627318718389 1.7084703361345437 0.0875491059967492 1.0 0.8922760896931355 3 Q9UG56,P35790 2 Rhog gtpase cycle 0.5637871971617906 1.6996335493819903 0.089199875675173 1.0 0.8922760896931355 41 O95202,P50402,Q86XL3,O15173,Q14739,Q86Y07,O75962,Q8TAA9,Q14185,P42167 10 Carboxyterminal post translational modifications of tubulin 0.7152943475013387 1.6907572787510168 0.090883169606478 1.0 0.8922760896931355 7 Q13885,P68371,Q9BUF5,P04350,Q9BVA1 5 Wax and plasmalogen biosynthesis 0.7497187851518445 1.680415929157655 0.0928764189321511 1.0 0.8922760896931355 5 Q8WVX9,O15228,O00116,Q6IAN0 4 Metabolism of steroids 0.4267652448829133 1.6773379781796784 0.0934764100431775 1.0 0.8922760896931355 54 P04062,P30536,P38435,P37268,Q9HCL2,O95772,Q14739,Q14849,Q15392,Q53GQ0,Q15800,Q16850,O76062,Q9BWD1 14 Neuronal system 0.4062734392640864 1.6751162027596915 0.0939114345139455 1.0 0.8922760896931355 59 P53680,Q12959,Q14254,P07196,Q13885,Q96QD8,Q96RD7,Q9Y639,Q9BUF5,P04350,O75915,P10586,O75955,O95197,Q13509,Q13136,Q9BVA1,Q13555,P68371,Q14168,P21964 21 Transport of inorganic cations anions and amino acids oligopeptides 0.7035923502685517 1.6703922085502394 0.0948417901845795 1.0 0.8922760896931355 14 Q92581,P08195,Q96QD8,Q9H2J7,Q9Y6M7,P30825,Q70HW3,Q9UBX3,Q9H936 9 Ras processing 0.7448740846522545 1.6593849568022194 0.0970382456328975 1.0 0.8922760896931355 5 O60725 1 Post translational modification synthesis of gpi anchored proteins 0.7064253967657634 1.651384060144902 0.0986601775356139 1.0 0.8922760896931355 8 Q5H8A4,Q9H490,O43292 3 Beta oxidation of pristanoyl coa 0.7458103698225901 1.6037918324273228 0.1087599455279868 1.0 0.8922760896931355 4 O15254,P51659 2 Synthesis secretion and deacylation of ghrelin 0.8704507390305397 1.5967121721682933 0.110329881116419 1.0 0.8922760896931355 3 P67812 1 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.8704507390305397 1.5967121721682933 0.110329881116419 1.0 0.8922760896931355 3 P67812 1 Diseases of carbohydrate metabolism 0.6918439235255662 1.588622126820738 0.1121457296127408 1.0 0.8922760896931355 10 P54802,P10253,P16278,P08236,P15586 5 Pink1 prkn mediated mitophagy 0.6911913287648318 1.5826913354281182 0.1134918341483268 1.0 0.8922760896931355 9 O96008,Q9NS69,Q15388,P21796,Q8N4H5,Q8IWA4 6 Glycerophospholipid biosynthesis 0.6056805070931529 1.5716221935239412 0.1160381963151568 1.0 0.8922760896931355 33 Q9UG56,Q53H12,Q9NPH0,Q92604,Q8N2A8,Q9HBU6,Q8NCC3,P35790,Q8IV08,Q9HCL2,Q96N66,Q9NQZ5 12 Synaptic adhesion like molecules 0.6879633679538856 1.566107394245197 0.1173234773324702 1.0 0.8922760896931355 8 P10586,O75955,O95197,Q12959,Q14254 5 Synthesis of pc 0.6865864004984017 1.5594674087211502 0.1188857925724116 1.0 0.8922760896931355 7 P35790,Q9NQZ5 2 Unblocking of nmda receptors glutamate binding and activation 0.6845053566243039 1.5508800727099945 0.1209304267459441 1.0 0.8922760896931355 6 P07196,Q13555,Q12959,Q14168 4 Ras activation upon ca2 influx through nmda receptor 0.6845053566243039 1.5508800727099945 0.1209304267459441 1.0 0.8922760896931355 6 P07196,Q13555,Q12959,Q14168 4 Long term potentiation 0.6845053566243039 1.5508800727099945 0.1209304267459441 1.0 0.8922760896931355 6 P07196,Q13555,Q12959,Q14168 4 Nuclear envelope ne reassembly 0.4137976198203129 1.543244539763656 0.1227714543235478 1.0 0.8922760896931355 54 Q96FZ7,P50402,P02545,P06493,P42167,Q92621,Q13885,Q86XL3,P37198,Q9BUF5,Q9BW27,Q7Z3B4,P04350,Q8N1F7,P42166,Q13509,Q14739,P20700,Q5SRE5,Q86Y07,Q9BVA1,O95067,P68371,Q8IXJ6,Q92973,Q9BTX1 26 Cytosolic sulfonation of small molecules 0.7159129529958521 1.5329876168330714 0.1252789060390107 1.0 0.8922760896931355 5 P0DMN0 1 Vitamin d calciferol metabolism 0.8535694210230489 1.5318618958114936 0.1255565181677407 1.0 0.8922760896931355 3 P04062,P38435 2 Negative regulation of nmda receptor mediated neuronal transmission 0.6761922537170657 1.5115962594636922 0.1306366038532007 1.0 0.8934072593249772 7 P07196,Q13555,Q12959,Q14168 4 Slc mediated transmembrane transport 0.6389809443244762 1.4903756363580822 0.1361254949265316 1.0 0.8934072593249772 24 Q92581,P08195,Q96QD8,P12236,Q9H2J7,Q8WWI5,P35613,P30825,Q9Y6M7,Q70HW3,P53985,Q9UBX3,P05141,Q9H936,Q8TB61 15 Cristae formation 0.6550845100672081 1.4855661691537172 0.1373939090815781 1.0 0.8934072593249772 19 Q6UXV4,Q9NX63,O75431,P06576,P56385,Q5XKP0,Q13505,Q9Y512,P24539,Q16891,O75964 11 The citric acid tca cycle and respiratory electron transport 0.437297514507582 1.4686178567740364 0.1419364687116069 1.0 0.9080234131063616 99 O75380,Q9Y6M9,Q96I36,P21796,P47985,O43676,Q9Y6N1,Q9UDW1,Q9P0J0,P24539,O75964,O96000,O43674,P15954,O95563,O14949,P06576,Q9Y375,P56385,P20674,P00403,Q86Y39,Q9NPL8,O95168,P35613,O75880,Q13423,P53985,P03886,P51970,P22695,P13073,Q16134,P21912,O43819 35 Attachment of gpi anchor to upar 0.6957609861136127 1.4444326453512977 0.1486173133530794 1.0 0.931223994535157 5 Q9H490,O43292 2 Hyaluronan uptake and degradation 0.6948826513956687 1.440563258006266 0.1497081067701704 1.0 0.931223994535157 5 P08236,P06865 2 Hyaluronan metabolism 0.6948826513956687 1.440563258006266 0.1497081067701704 1.0 0.931223994535157 5 P08236,P06865 2 Inflammasomes 0.6591424817135264 1.4346917547423388 0.151374954823563 1.0 0.9333687170780391 6 P05067,P09601 2 The nlrp3 inflammasome 0.6591424817135264 1.4346917547423388 0.151374954823563 1.0 0.9333687170780391 6 P05067,P09601 2 Defects in cobalamin b12 metabolism 0.6841232018405781 1.3931065480485294 0.1635875733034084 1.0 0.945964562658852 5 O14678 1 Maturation of sars cov 2 spike protein 0.6459236665867164 1.3728068603965804 0.1698123974472551 1.0 0.945964562658852 11 P27824,P04843,P46977,Q16706,P61803 5 Cytochrome p450 arranged by substrate type 0.7999229013884123 1.3250226588535248 0.1851636360823327 1.0 0.945964562658852 3 Q16850 1 Purinergic signaling in leishmaniasis infection 0.667759458369983 1.320756637884719 0.1865825223432697 1.0 0.945964562658852 5 P09601 1 Abc transporters in lipid homeostasis 0.7953906689151233 1.3075311022799545 0.1910323989467792 1.0 0.945964562658852 3 P56589,P40855 2 Mitophagy 0.6308203073678559 1.3064448352183806 0.1914013272372035 1.0 0.945964562658852 13 O96008,Q9NS69,Q15388,P21796,Q8N4H5,Q8IWA4 6 Autophagy 0.3715360148770121 1.2877789054381876 0.1978229373220121 1.0 0.9494113241991928 59 P13473,O96008,Q9NS69,Q15388,Q13885,P68371,Q13509,P21796,Q9BUF5,Q8N4H5,P04350,Q9BVA1,Q8IWA4,P08670 14 Depolymerisation of the nuclear lamina 0.6281166123313012 1.28523623204533 0.1987097460191236 1.0 0.9494113241991928 9 P42167,P50402,P02545 3 Proton coupled monocarboxylate transport 0.9412756392245012 1.2810172854296686 0.2001875947454241 1.0 0.9494113241991928 2 P35613 1 Cdc6 association with the orc origin complex 0.7854358256646392 1.2691232874214324 0.2043970957828729 1.0 0.9537245100308874 3 Q9Y619 1 Sialic acid metabolism 0.6529408591190577 1.255107646499516 0.2094396850272817 1.0 0.9537245100308874 5 P10619 1 Cobalamin cbl vitamin b12 transport and metabolism 0.6191877902969346 1.2500931684718466 0.2112655150431688 1.0 0.9537245100308874 6 Q9NPF0,O14678 2 Rho gtpases activate iqgaps 0.6138167269806201 1.2267934666867435 0.2199002270222414 1.0 0.9617406993398524 14 Q13885,P68371,Q9BUF5,P04350,Q9BVA1 5 Translation of sars cov 1 structural proteins 0.6098644822142063 1.2029385128962693 0.2290001153876377 1.0 0.964793257697682 7 P27824,Q10472 2 Ire1alpha activates chaperones 0.5869843513791922 1.199327065940892 0.2304007947948068 1.0 0.964793257697682 24 O95070,P43307,O76024,Q9Y5M8,O14773,Q9NWM8 6 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.5899240364387622 1.181606605748139 0.2373618312371779 1.0 0.964793257697682 22 Q86UP2,P14625,Q07065,Q5JRA6,O43852,O76024,O43493,Q13217,Q06481,Q8NBJ4,O00255,Q15293,P05067,P11047,Q02818 15 Assembly of the hiv virion 0.6423455886207174 1.1535464779414737 0.2486861521021528 1.0 0.964793257697682 4 Q9H9H4,Q96EY5 2 Rnd2 gtpase cycle 0.5887658508293778 1.1478893473689509 0.2510142463651421 1.0 0.9651815142348444 20 Q8TAA9,P51648 2 Rac3 gtpase cycle 0.5021619526862697 1.1386552791968876 0.2548469622259532 1.0 0.9683075918483728 39 P50402,Q9UQB8,O15173,Q14739,Q86Y07,Q9H0H5,O75962,Q8TAA9,P42167 9 Reduction of cytosolic ca levels 0.6380336483103444 1.1347547911142948 0.2564780731949656 1.0 0.9683075918483728 4 P20020,P16615 2 Platelet calcium homeostasis 0.6380336483103444 1.1347547911142948 0.2564780731949656 1.0 0.9683075918483728 4 P20020,P16615 2 Cs ds degradation 0.8921045237426208 1.0945897492674164 0.2736964084592013 1.0 0.977102536765486 2 P06865 1 Golgi to er retrograde transport 0.3715704274140391 1.0896313027992592 0.2758755883820358 1.0 0.977102536765486 73 Q12981,Q15363,Q13885,O75935,P68371,Q9P2W9,Q9Y3B3,Q9BVK6,Q9BUF5,P24390,Q9H0H5,P04350,Q9BVA1,Q6NUQ1,Q10472,O15260 16 Alpha oxidation of phytanate 0.613696152728316 1.0811312493658958 0.2796387346311437 1.0 0.977102536765486 5 Q9BY49,P51648 2 Unwinding of dna 0.5836537330491303 1.0716185327069498 0.283891405781252 1.0 0.977102536765486 10 P33991 1 Phase i functionalization of compounds 0.5795478949480581 1.0591275045416797 0.289541715327001 1.0 0.977102536765486 15 P07099,P16435,O43169,Q16850 4 Cholesterol biosynthesis 0.5717119120339058 1.0564773347094956 0.2907501905615617 1.0 0.977102536765486 20 P37268,Q14739,Q15392,Q16850,Q15800,O76062,Q9BWD1 7 Initiation of nuclear envelope ne reformation 0.5730515516807528 1.053357611326187 0.2921771238592621 1.0 0.977102536765486 19 P50402,Q86XL3,Q14739,P20700,P02545,Q8IXJ6,P42167 7 Formyl peptide receptors bind formyl peptides and many other ligands 0.7271849649520227 1.0454944249108564 0.2957945159352104 1.0 0.977102536765486 3 P05067 1 Selective autophagy 0.5115528228708718 1.03444579772181 0.300927803628586 1.0 0.977102536765486 35 O96008,Q9NS69,Q15388,Q13885,P68371,Q13509,O95140,P21796,Q9BUF5,Q8N4H5,P04350,Q9BVA1,Q8IWA4,P08670 14 Processing of smdt1 0.5737069654094216 1.0226390055251866 0.3064785601210567 1.0 0.977102536765486 11 Q10713,Q9BPX6 2 Interleukin 4 and interleukin 13 signaling 0.5735396040953429 1.0217940717738283 0.3068783757632198 1.0 0.977102536765486 12 P08670,P09601 2 Formation of atp by chemiosmotic coupling 0.5726858330531588 1.0211381527924956 0.3071889892762904 1.0 0.977102536765486 9 P24539,P06576,O75964 3 Er quality control compartment erqc 0.7117276613864195 0.9867843179413108 0.3237483841709756 1.0 0.983089139414401 3 Q9UBV2 1 Glutamate neurotransmitter release cycle 0.6032764811404574 0.9839430718760206 0.3251435043247346 1.0 0.983089139414401 4 O75915,Q96QD8 2 Transport of small molecules 0.4577674753624473 0.944258420188586 0.3450376081895578 1.0 0.9957227448465946 164 Q9Y487,P30519,Q8N4V1,P21796,P09601,P30825,P05023,Q70HW3,P51798,P16615,Q10713,P45880,Q9C0H2,Q96QD8,P56589,Q9BUN8,P27105,O15118,Q9Y6M7,P49721,P28072,Q8TB61,O95202,P12236,Q4KMQ2,Q8IYU8,P35613,P61289,P53985,Q9Y277,P61916,P08183,P98194,P35670,Q9HD20,O00231,P28070,Q8WTV0,O75027,Q8WWI5,Q9BPX6,Q93050,Q9UBX3,P51790,P40855,Q9UBV2 46 Synthesis of leukotrienes lt and eoxins ex 0.6950534007869631 0.9239396482862682 0.3555177387279911 1.0 0.9957227448465946 3 P33527,Q14914 2 Ion homeostasis 0.5511756611851224 0.9135146081460396 0.3609719542021292 1.0 0.9974410945859228 11 P20020,Q13555,P05023,O43865,P16615 5 Cardiac conduction 0.5511756611851224 0.9135146081460396 0.3609719542021292 1.0 0.9974410945859228 11 P20020,Q13555,P05023,O43865,P16615 5 E2f enabled inhibition of pre replication complex formation 0.5742391019123023 0.9072878268218194 0.3642546098394774 1.0 0.9986941924142564 5 Q9Y619 1 Mitochondrial biogenesis 0.4865055360048408 0.9012964824012798 0.3674307035710844 1.0 1.0 36 Q6UXV4,Q9NX63,O75431,P06576,O00411,P56385,Q5XKP0,Q13505,Q9Y512,P24539,Q16891,O75964 12 Binding and uptake of ligands by scavenger receptors 0.5439270972583609 0.8946536635219388 0.3709722556764996 1.0 1.0 7 Q8WTV0 1 Chaperone mediated autophagy 0.5419077635774975 0.8852772615011761 0.3760071107043174 1.0 1.0 7 P08670 1 Abacavir transport and metabolism 0.8286035403203048 0.8601689079867545 0.3896959410197453 1.0 1.0 2 P08183 1 Dap12 interactions 0.5632906386873031 0.8595119200796774 0.3900581464312187 1.0 1.0 5 P01889 1 Intra golgi traffic 0.5378479514010958 0.8472717980976165 0.3968436422166184 1.0 1.0 14 Q8TBA6,O95721,Q96MW5,Q16706,O00461 5 Recruitment of numa to mitotic centrosomes 0.4363465026775058 0.844731270588195 0.3982608959567018 1.0 1.0 43 Q13885,O75935,Q96CS2,O95684,Q13509,P68371,O43805,Q9H6D7,P07437,Q9BUF5,P04350,Q9BVA1,O94927,P41208,Q9UGJ1 15 Rnd1 gtpase cycle 0.53441471060863 0.8429605925459913 0.3992504837228048 1.0 1.0 18 P51648,Q15058,O75976,Q14254,Q8TAA9,P38159 6 Cytoprotection by hmox1 0.346037964082468 0.8425521025718516 0.3994789884471414 1.0 1.0 70 P28074,P30519,P28070,Q8TCT9,Q96I36,P15954,Q9UL46,P13073,O75880,P09601,P61289,O43819,Q9Y6N1,P49721,P28072,P20674,P00403,O00231 18 Activation of kainate receptors upon glutamate binding 0.5545399164635405 0.8215398946259109 0.4113388096095471 1.0 1.0 5 Q92796,P63218,Q12959 3 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.5645504705470891 0.8185612064479076 0.4130368078785071 1.0 1.0 4 P51659 1 Class b 2 secretin family receptors 0.6646232299491946 0.8109899184066751 0.4173714603529386 1.0 1.0 3 P63218 1 Reactions specific to the complex n glycan synthesis pathway 0.8148356279853798 0.8108399158179241 0.4174576086071222 1.0 1.0 2 P04066 1 N glycan antennae elongation in the medial trans golgi 0.8148356279853798 0.8108399158179241 0.4174576086071222 1.0 1.0 2 P04066 1 Wnt ligand biogenesis and trafficking 0.5220744751631958 0.8009290929550189 0.4231726964856193 1.0 1.0 6 Q5T9L3 1 Complex i biogenesis 0.4849091185176404 0.7940354194887 0.4271748118167475 1.0 1.0 33 Q9NX14,Q86Y39,O96000,Q9NPL8,O75380,O43674,Q9Y6M9,O95168,Q8TB37,O43676,P03886,Q9P0J0,Q9Y375,P51970 14 Metabolism of folate and pterines 0.5245775203408405 0.7935463502676693 0.42745957579622 1.0 1.0 9 Q9H2D1,P34897,Q05932,P34896,P00374 5 Intra golgi and retrograde golgi to er traffic 0.3718144944439108 0.7889690095666401 0.4301301196959921 1.0 1.0 96 Q12981,Q13885,O75935,Q9P2W9,Q9Y3B3,Q9BVK6,Q9BUF5,P24390,P04350,Q15363,Q8TBA6,O43493,Q9H0H5,Q6NUQ1,Q9BVA1,O15260,Q10472,O00461,P68371,O60499 20 Receptor type tyrosine protein phosphatases 0.8002247822422005 0.7592655031128084 0.4476937491023411 1.0 1.0 2 P10586 1 Signaling by erbb4 0.5135602356196076 0.7546435066356195 0.45046291167929 1.0 1.0 7 Q92542 1 Cd28 dependent pi3k akt signaling 0.7954481595953926 0.7425950711994032 0.4577268734680086 1.0 1.0 2 P42345 1 Diseases of glycosylation 0.508184706276351 0.7254440797965576 0.4681796391873032 1.0 1.0 21 P07686,P06865,P16278,O43505,Q9BT22,P10619,Q8NCH0 7 Noncanonical activation of notch3 0.7887046923292964 0.7192321359545866 0.4719979020545333 1.0 1.0 2 Q92542 1 G protein activation 0.6391231028667842 0.7186520910192319 0.4723553091067745 1.0 1.0 3 P63218,Q9UBI6 2 Metabolism of fat soluble vitamins 0.5018449193249371 0.7093776026080763 0.4780901828714397 1.0 1.0 6 Q8N0U8 1 Cargo concentration in the er 0.5096658136487876 0.7086228203060688 0.4785585710303728 1.0 1.0 15 P53634,Q15363,Q5JRA6,P49755,Q96PC5 5 Post chaperonin tubulin folding pathway 0.5074807152899496 0.7046573301589824 0.4810235115746466 1.0 1.0 11 Q13885,P68371,Q9BUF5,P04350,Q9BVA1 5 Ca2 pathway 0.499134351400976 0.6972242082156243 0.4856624912598388 1.0 1.0 6 P63218,Q9HCE1 2 Organelle biogenesis and maintenance 0.3726752772531619 0.6873712054034502 0.4918488381312902 1.0 1.0 105 Q9NX63,Q96CS2,O43805,O00411,Q13505,Q9Y512,Q10713,P24539,P41208,O75964,Q6UXV4,Q13885,P78371,O75935,P06576,Q9H6D7,P07437,Q9BUF5,P04350,P56385,O43924,O75431,A6NIH7,O95684,Q13509,Q68CZ6,Q9BVA1,P68371,Q5XKP0,O94927,Q9NVH1,Q16891 32 Sealing of the nuclear envelope ne by escrt iii 0.5038717501869936 0.6818738268178115 0.4953187366263507 1.0 1.0 13 Q13885,P68371,Q9BUF5,P04350,Q9BVA1 5 Protein protein interactions at synapses 0.5036824552306238 0.6799401025093512 0.4965423879209605 1.0 1.0 16 P10586,O75955,O95197,Q13136,Q12959,Q14168,Q14254 7 Acyl chain remodelling of pg 0.7715650463613283 0.6608293956836563 0.5087217289453789 1.0 1.0 2 Q92604 1 Rhod gtpase cycle 0.4635386012589032 0.6570811757356566 0.511128722133166 1.0 1.0 33 P50402,Q9UIW2,P49257,P42166,Q68EM7,O15173,Q86YQ8,Q9Y6M7,Q5JTV8,Q14739,P20700,Q86Y07,Q9H0H5,Q8TAA9,P12814,P42167 16 Unfolded protein response upr 0.4300211382344341 0.655971257728554 0.5118426177135076 1.0 1.0 40 O95070,P43307,O76024,Q9Y5M8,O14773,Q9NWM8 6 Diseases associated with n glycosylation of proteins 0.4890665642428116 0.6523639017658476 0.5141664456757402 1.0 1.0 6 Q9BT22 1 Trafficking and processing of endosomal tlr 0.7648215790952452 0.6382677516840051 0.5232994004337956 1.0 1.0 2 Q99538 1 Transmission across chemical synapses 0.3753876164335737 0.6286140661975987 0.5296017492250729 1.0 1.0 48 P53680,P07196,Q13885,Q96QD8,Q13555,Q13509,Q13136,P68371,Q12959,Q9Y639,Q9BUF5,Q14168,P04350,Q9BVA1,O75915,P21964 16 Translation of sars cov 2 structural proteins 0.4914537598891513 0.6229362866151175 0.533326391382734 1.0 1.0 18 P27824,P49840,P48729,P04843,P46977,Q16706,P61803,Q10472 8 Rnd3 gtpase cycle 0.488826170458525 0.6174266767969808 0.536953330742846 1.0 1.0 20 Q07065,Q9NYL9,Q14254,Q8TAA9,P38159 5 Synthesis of pips at the golgi membrane 0.4811786736051122 0.6009720251882358 0.5478586190556478 1.0 1.0 8 Q10713,Q9BTU6 2 Activation of nmda receptors and postsynaptic events 0.4759376890432887 0.6006172337096864 0.54809495677189 1.0 1.0 26 P07196,Q13885,Q13555,P68371,Q12959,Q9BUF5,Q14168,P04350,Q9BVA1 9 Rac1 gtpase cycle 0.3560916630827218 0.5879961131571861 0.5565349017410983 1.0 1.0 50 P50402,Q9UQB8,Q14739,Q86Y07,Q9H0H5,O75962,Q8TAA9,Q14185,P42167 9 Lipophagy 0.5068878268203403 0.5830161304695288 0.5598824414928745 1.0 1.0 4 P11142,P54646,P54619 3 Signaling by flt3 fusion proteins 0.5066289025688884 0.5820012920248372 0.5605658105977416 1.0 1.0 4 Q01082 1 Iron uptake and transport 0.4810377274350814 0.5708337174034458 0.568112364813623 1.0 1.0 18 P30519,P09601 2 Muscle contraction 0.4677733100165684 0.5677469104756375 0.5702068333686352 1.0 1.0 27 P20020,Q13555,Q9NYL9,P67936,P05023,P09493,O43865,P16615,P06753,P08670 10 Cell surface interactions at the vascular wall 0.4793264079850475 0.5623363377513383 0.5738868848802521 1.0 1.0 18 Q08722,P35613,Q92896,P53985,P14174 5 Gap junction trafficking and regulation 0.4769009122912643 0.5543927539604976 0.5793100840135077 1.0 1.0 13 Q13885,P68371,Q13509,Q9BUF5,P04350,Q9BVA1 6 Presynaptic function of kainate receptors 0.7386906434391683 0.5533519980271177 0.580022401627309 1.0 1.0 2 P63218 1 Potassium channels 0.7386906434391683 0.5533519980271177 0.580022401627309 1.0 1.0 2 P63218 1 Inwardly rectifying k channels 0.7386906434391683 0.5533519980271177 0.580022401627309 1.0 1.0 2 P63218 1 Glucagon type ligand receptors 0.7386906434391683 0.5533519980271177 0.580022401627309 1.0 1.0 2 P63218 1 Prostacyclin signalling through prostacyclin receptor 0.7386906434391683 0.5533519980271177 0.580022401627309 1.0 1.0 2 P63218 1 Synthesis of pips at the early endosome membrane 0.4904398593769155 0.552619316545623 0.5805241120619078 1.0 1.0 5 Q96PE3 1 Calnexin calreticulin cycle 0.4698729597859405 0.5509481849738554 0.5816691948031338 1.0 1.0 8 P27824,Q9UBV2 2 Rhoh gtpase cycle 0.4720745633124429 0.549052087870103 0.582969704270174 1.0 1.0 23 Q8TAA9,P27105 2 Arachidonate production from dag 0.7254846867097379 0.512123724496986 0.6085644214775172 1.0 1.0 2 Q8NCG7 1 Notch3 activation and transmission of signal to the nucleus 0.5782908740679689 0.5110611993320551 0.6093082040674092 1.0 1.0 3 Q92542 1 Scavenging by class a receptors 0.5777585280899012 0.5093456290332964 0.6105099799389504 1.0 1.0 3 Q5KU26 1 Pre notch expression and processing 0.4659863475746792 0.5083576892288673 0.6112025195115092 1.0 1.0 12 Q15363,P16615 2 Non integrin membrane ecm interactions 0.4576107550601749 0.5063378763392141 0.6126194777847416 1.0 1.0 7 P11047,P12814 2 Vitamin b1 thiamin metabolism 0.722393930879448 0.5026533820838307 0.6152079907802399 1.0 1.0 2 Q9HC21 1 Abc family proteins mediated transport 0.3232632151989278 0.4950563604623954 0.6205603370950872 1.0 1.0 53 P28074,P28070,Q9GZP9,P56589,Q9BUN8,O75027,P61289,P49721,P28072,P40855,P08183,Q9UBV2,O00231 13 Peptide hormone metabolism 0.4643543600402167 0.4931574274614643 0.6219013562287863 1.0 1.0 14 Q9UPT5,P67812,Q15005,O60282 4 Chylomicron assembly 0.7184602416409109 0.4907023904673197 0.6236369555248562 1.0 1.0 2 Q9Y6B6 1 Plasma lipoprotein remodeling 0.7184602416409054 0.4907023904673037 0.6236369555248675 1.0 1.0 2 Q9BU23 1 Plasma lipoprotein clearance 0.4621666019855735 0.4866747017081946 0.6264888759132337 1.0 1.0 13 Q8WTV0,O15118 2 Transport of vitamins nucleosides and related molecules 0.4523475065372536 0.4839799286497985 0.6284001137362913 1.0 1.0 7 Q8TB61,P12236 2 Fatty acyl coa biosynthesis 0.4625941577540156 0.4800156331852802 0.6312162768623706 1.0 1.0 17 Q6Y1H2,Q9UMR5,P50897,Q9P035,Q9UKU0,O00767,Q53GQ0,Q9NZ01 8 Gaba receptor activation 0.4459487521393083 0.4668435357466862 0.6406118253742605 1.0 1.0 6 Q9Y639,P63218 2 Dopamine neurotransmitter release cycle 0.7086260185445301 0.461342211990788 0.6445531044388741 1.0 1.0 2 Q13136 1 Establishment of sister chromatid cohesion 0.448690053644304 0.4596292018010774 0.6457823949413137 1.0 1.0 8 Q8WVM7,Q29RF7,Q7Z5K2,Q9NTI5 4 Sulfur amino acid metabolism 0.4472553408571884 0.4378051240490764 0.6615275561940441 1.0 1.0 10 Q9UBX3 1 Antigen presentation folding assembly and peptide loading of class i mhc 0.45315972772924 0.4350980953822887 0.6634912258512817 1.0 1.0 18 P27824,P04439,Q03518,Q03519,P01889,P10321,P51572 7 Synthesis of bile acids and bile salts 0.4389151736423803 0.4279728706477462 0.6686708720716632 1.0 1.0 7 O14734,P51659,Q9BXW6 3 Bile acid and bile salt metabolism 0.4389151736423803 0.4279728706477462 0.6686708720716632 1.0 1.0 7 O14734,P51659,Q9BXW6 3 Constitutive signaling by overexpressed erbb2 0.4621872364351924 0.4158991016853535 0.6774838368853962 1.0 1.0 4 Q16543,P07900,P62993 3 Cilium assembly 0.3067144244231115 0.4145342603686398 0.6784828816493311 1.0 1.0 69 Q96CS2,O43805,Q10713,P41208,Q13885,P78371,O75935,Q9H6D7,P07437,Q9BUF5,P04350,O43924,A6NIH7,O95684,Q13509,Q68CZ6,Q9BVA1,P68371,O94927 19 Ionotropic activity of kainate receptors 0.5468182021242498 0.4134220280743875 0.6792974383204327 1.0 1.0 3 Q12959 1 Nrcam interactions 0.5468182021242498 0.4134220280743875 0.6792974383204327 1.0 1.0 3 Q12959 1 Gamma carboxylation hypusine formation and arylsulfatase activation 0.4442768775987902 0.4121380384024241 0.6802382493992436 1.0 1.0 12 O43681,P38435,O60725 3 Deposition of new cenpa containing nucleosomes at the centromere 0.4421986749734982 0.4093306542093756 0.6822970224118317 1.0 1.0 11 Q9BS16 1 Tysnd1 cleaves peroxisomal proteins 0.4522885654714734 0.4050259202485636 0.685458458120825 1.0 1.0 5 P51659,O00116 2 Cohesin loading onto chromatin 0.4364162505924282 0.3919572734129001 0.6950897837736079 1.0 1.0 10 Q8WVM7,Q7Z5K2,Q29RF7,Q9Y6X3,Q9NTI5 5 Slc transporter disorders 0.4130307166617848 0.3856194774672804 0.6997785059656283 1.0 1.0 35 Q92581,Q92621,P08195,Q8TEM1,P37198,P35613,Q99567,Q9BW27,P53985,Q5SRE5,Q7Z3B4,A8CG34,P12270,Q8N1F7,Q9BTX1,O15504 16 Metabolism of lipids 0.4450762558361497 0.3805241101435007 0.7035564028830295 1.0 1.0 210 Q6Y1H2,P07686,Q8N2A8,Q12770,Q06136,Q14534,Q9HCL2,Q71SY5,Q96G23,O43772,P04035,Q10713,P07602,Q9NZ01,Q13510,P50897,P06280,P23786,P38435,Q8IV08,O15121,O95772,P16278,Q9NRA0,Q16850,O15254,O76062,Q9BWD1,P10619,Q96N66,Q9UG56,Q53H12,P06865,P51648,Q9UMR5,Q8N5B7,P35790,O00116,Q14739,Q14849,Q15165,Q15800,Q9NQZ5,Q9NPH0,O15269,P17900,P04062,Q92604,O95470,Q8NCC3,Q9NZJ7,Q9P035,P30536,P37268,Q9UKU0,Q14914,Q9HBU6,Q8WWI5,Q15392,Q53GQ0,Q16739 61 Peroxisomal lipid metabolism 0.4335540861910575 0.3604837486165214 0.7184854076001348 1.0 1.0 13 Q15067,P51648,O15254,Q5T8D3,O43808,Q9BY49,P51659 7 Platelet activation signaling and aggregation 0.2873956766443038 0.3583226289955562 0.7201018853961845 1.0 1.0 57 P13473,O43852,Q9NZJ7,Q8NBX0,Q8NCG7,Q9UEU0,O94919,Q06481,Q08380,Q92520,P05067,P07602 12 Intraflagellar transport 0.4302467436881798 0.3464394379149331 0.7290124907951157 1.0 1.0 13 Q13885,P68371,Q13509,Q9BUF5,P04350,Q9BVA1 6 Signaling by gpcr 0.3484471180257739 0.3404587621567996 0.733511072881696 1.0 1.0 47 Q13555,P22466,Q9NZJ7,Q8NCG7,P05067,P07602,P42892 7 Copi mediated anterograde transport 0.2914396739978848 0.3285522203193334 0.7424941673890633 1.0 1.0 55 Q15363,Q13885,O75935,P68371,P49755,Q9Y3B3,Q9BVK6,Q9BUF5,P24390,P04350,Q9BVA1,Q13813 12 N glycan trimming in the er and calnexin calreticulin cycle 0.4279909057960383 0.3272071683904679 0.7435111994628569 1.0 1.0 15 P27824,Q9BUN8,Q9UBV2 3 Nuclear envelope breakdown 0.3635956965282582 0.3241817650419198 0.7458004266427183 1.0 1.0 44 P50402,Q99567,P02545,P06493,P42167,Q92621,P37198,Q9BW27,Q7Z3B4,O15504,Q8N1F7,P42166,Q8TEM1,P20700,Q5SRE5,A8CG34,Q86Y07,P12270,O95067,Q9BTX1 20 Type i hemidesmosome assembly 0.5140528386734193 0.3211594895502332 0.7480895299254087 1.0 1.0 3 P23229,Q15149 2 Assembly of collagen fibrils and other multimeric structures 0.5140528386734193 0.3211594895502332 0.7480895299254087 1.0 1.0 3 P23229,Q15149 2 Kinesins 0.4273502912404328 0.3176756365984156 0.7507309937825406 1.0 1.0 22 Q13885,P68371,Q13509,Q9BUF5,Q9H0H5,P04350,Q9BVA1 7 Rhobtb3 atpase cycle 0.4254780652418525 0.3098579839854044 0.7566689551959955 1.0 1.0 5 O14964,P51151,O60664,Q15345 4 Biological oxidations 0.3502969310945772 0.3075608876170785 0.7584164855542963 1.0 1.0 46 P0DMN0,P30837,Q9NUJ1,P16435,Q16850,P07099,Q8TB61,O43169 8 Sting mediated induction of host immune responses 0.3977496483825761 0.2787544014276571 0.7804333102082408 1.0 1.0 6 P13010,P12956,P19474,Q9UJV9,P49959 5 Response to elevated platelet cytosolic ca2 0.4015778426151082 0.2786462769652126 0.7805162947794109 1.0 1.0 33 P13473,O43852,Q9NZJ7,Q8NBX0,Q12846,Q9UEU0,O94919,Q06481,Q08380,Q92520,P05067,P07602 12 Recruitment of mitotic centrosome proteins and complexes 0.3807154716457284 0.27779508606666 0.7811696635297123 1.0 1.0 39 O75935,Q96CS2,O95684,O43805,Q9H6D7,P07437,P04350,O94927,P41208,Q9UGJ1 10 Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4073427655532485 0.2753835198742447 0.783021604034964 1.0 1.0 10 P07196,Q13555,Q12959,Q14168 4 Cellular response to chemical stress 0.3059370944158259 0.2692732449578267 0.7877194194710186 1.0 1.0 80 P28074,P30519,Q96I36,P09601,Q9Y6N1,P15954,P49721,P28072,P20674,P00403,Q8TCT9,Q8TED1,O75880,P61289,O00231,P28070,Q9UL46,P13073,O43819 19 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.4128064582969598 0.2686574065768465 0.7881933316461684 1.0 1.0 14 P05067,P09601 2 Ion channel transport 0.399302538513187 0.2656381341949274 0.7905179135538991 1.0 1.0 33 Q9HD20,Q9Y487,Q9C0H2,Q4KMQ2,P27105,P05023,Q93050,P51798,P16615,P51790,P98194,P35670 12 Diseases associated with glycosylation precursor biosynthesis 0.3995593907281762 0.2645118974759016 0.7913854983310369 1.0 1.0 8 P10619 1 Formation of tubulin folding intermediates by cct tric 0.4080897558654963 0.2497189970109603 0.8028046660577348 1.0 1.0 14 Q13885,P68371,P78371,Q9BUF5,P04350,Q9BVA1 6 Maturation of sars cov 1 spike protein 0.4073657576609322 0.2404785859158978 0.8099592622197678 1.0 1.0 4 Q13724,P27824,P14314 3 Activation of rac1 downstream of nmdars 0.479201798763358 0.2355301207821948 0.8137973033082866 1.0 1.0 3 Q14012,P63000 2 Activation of the pre replicative complex 0.4096746233036157 0.2350123163612124 0.8141991738370336 1.0 1.0 21 P33991,P24941,Q9Y619,Q9UBD5 4 Caspase mediated cleavage of cytoskeletal proteins 0.382073669103691 0.2237860908157767 0.8229237534313025 1.0 1.0 6 P08670 1 Irf3 mediated induction of type i ifn 0.3976377952756007 0.2206144469517343 0.8253926511708454 1.0 1.0 5 P49959,Q9UJV9,P13010,P12956 4 Pi5p regulates tp53 acetylation 0.3992128197919625 0.2179169898318242 0.8274937892763197 1.0 1.0 4 P48426,Q13526,Q8TBX8 3 Prevention of phagosomal lysosomal fusion 0.3989316840033698 0.2171571299419439 0.8280858928049799 1.0 1.0 4 O14964,Q9H267,P51149 3 Adp signalling through p2y purinoceptor 1 0.3952769187517464 0.2073907437572659 0.8357047108746221 1.0 1.0 4 P63218,Q9UBI6,P29992 3 Aggrephagy 0.3996784723875231 0.2013922695524841 0.8403918593869109 1.0 1.0 17 Q13885,P68371,Q9BUF5,P04350,Q9BVA1,P08670 6 G beta gamma signalling through pi3kgamma 0.3927723906991054 0.2008189354490549 0.8408401561930994 1.0 1.0 4 P31751,P63218 2 Signaling by hedgehog 0.276016705436205 0.1969888630878911 0.8438362529964756 1.0 1.0 60 P28074,Q9BVA1,P28070,Q13885,Q9GZP9,P68371,Q13509,P48729,P61289,Q9BUF5,Q6PHR2,P49721,P04350,P28072,Q9UBV2,O00231 16 G alpha s signalling events 0.3718706047820018 0.189994828157117 0.8493131832502474 1.0 1.0 6 Q9Y3E5,Q9UBI6,P63218,P04899,P08754 5 Rhobtb1 gtpase cycle 0.3987581153432021 0.1888803263896655 0.85018661329333 1.0 1.0 20 P62995,P38159,P78371,P08670 4 G alpha i signalling events 0.3972776619585917 0.1888577720909933 0.850204290897985 1.0 1.0 26 P22466,Q9NZJ7,P07602 3 Synthesis of substrates in n glycan biosythesis 0.3943395586146473 0.1849778123170666 0.8532464384498046 1.0 1.0 16 P10619,Q86YN1 2 Ros and rns production in phagocytes 0.378751555517476 0.1813923985162237 0.8560595850159152 1.0 1.0 9 Q93050 1 Inactivation of cdc42 and rac1 0.4525014052838758 0.1797398839271327 0.857356780472291 1.0 1.0 3 O94813,P63000 2 Amyloid fiber formation 0.3732324264340432 0.1730089791753757 0.8626443696953181 1.0 1.0 8 Q92542,Q9Y287 2 Hcmv early events 0.3138119382652696 0.1548271065809177 0.8769576209219909 1.0 1.0 49 Q92621,Q13885,P68371,Q13509,P12270,P83916,Q8TEM1,Q99567,Q9BUF5,Q9BW27,Q7Z3B4,P04350,Q9BVA1,A8CG34,Q8N1F7,Q9BTX1 16 Rhoc gtpase cycle 0.3608157200628497 0.1515569382057564 0.8795363992972205 1.0 1.0 39 O75955,P49257,P27105,Q14739,Q9H0H5,Q14254,Q8TAA9,P28288,P42167 9 Adrenaline noradrenaline inhibits insulin secretion 0.3716615125105429 0.1494507097321427 0.8811980004062221 1.0 1.0 4 P63218,Q9UBI6,P04899 3 Adp signalling through p2y purinoceptor 12 0.3717660292463483 0.1480324187151586 0.8823171836543973 1.0 1.0 5 P08754,P63218,Q9UBI6,P04899 4 Gaba b receptor activation 0.3717660292463483 0.1480324187151586 0.8823171836543973 1.0 1.0 5 P08754,P63218,Q9UBI6,P04899 4 Neurotransmitter release cycle 0.363319679938604 0.1414782983920403 0.8874921029652847 1.0 1.0 8 O75915,Q96QD8 2 Rho gtpases activate ktn1 0.3573905032991637 0.1339926783693557 0.893408364040895 1.0 1.0 7 P33176,Q9H0B6,Q86UP2 3 Neurotransmitter receptors and postsynaptic signal transmission 0.3578694452422918 0.1336343149592978 0.8936917481347555 1.0 1.0 39 P53680,P07196,Q13885,Q13555,P68371,Q13509,Q12959,Q9Y639,Q9BUF5,Q14168,P04350,Q9BVA1 12 Rhoj gtpase cycle 0.3844018066401296 0.1333830859596104 0.8938904213282006 1.0 1.0 27 P27105,Q86YQ8,Q9Y6M7,O75962,Q8TAA9,P42167 6 Retrograde transport at the trans golgi network 0.3838411730418591 0.1317408020939527 0.8951893113580063 1.0 1.0 19 P82094,P11717,O43493,P53365,O60499,P20645,Q9UID3 7 Inla mediated entry of listeria monocytogenes into host cells 0.5597077830851265 0.1312458786344876 0.8955808039179656 1.0 1.0 2 O60716 1 Disorders of transmembrane transporters 0.292335461375677 0.128954582691325 0.8973935864382119 1.0 1.0 80 P28074,Q99567,O14678,Q92621,P20618,Q9BUN8,Q9BW27,P49721,Q7Z3B4,P28072,O15504,Q8N1F7,Q9GZP9,Q8TEM1,P35613,P61289,P53985,A8CG34,P12270,O00231,P08195,P28070,Q9UL46,Q9BTX1,Q9UBV2 25 Aspartate and asparagine metabolism 0.3640672544228029 0.1285542688583417 0.8977103541109639 1.0 1.0 5 Q9UJS0 1 Plasma lipoprotein assembly remodeling and clearance 0.3793876297736691 0.123813579029821 0.9014628800353796 1.0 1.0 17 Q8WTV0,O15118 2 Syndecan interactions 0.3618549744686519 0.1231447592035119 0.9019924682665844 1.0 1.0 5 P12814 1 G2 m dna replication checkpoint 0.4135694500457623 0.1146538644231979 0.9087194835414 1.0 1.0 3 P06493 1 Cdc42 gtpase cycle 0.363403176061526 0.1107193400630691 0.9118389091209536 1.0 1.0 36 P27105,Q9UQB8,Q14739,Q9H0H5,Q8TAA9,P42167 6 Pre notch processing in the endoplasmic reticulum 0.4083754918493613 0.1074373832428776 0.9144419985860874 1.0 1.0 3 Q9H488,Q8NBL1 2 Activation of ppargc1a pgc 1alpha by phosphorylation 0.3951658234963546 0.0906027379642519 0.9278082563020214 1.0 1.0 3 P54646,P54619 2 Assembly of the orc complex at the origin of replication 0.3416692408257821 0.0893567167634328 0.9287984208326028 1.0 1.0 7 Q9Y619 1 Apoptotic cleavage of cellular proteins 0.3732923399741749 0.0885398210473293 0.9294476359793322 1.0 1.0 20 P20700,P51572,P02545,P08670 4 Nr1h2 and nr1h3 mediated signaling 0.3394949362099973 0.0835507440697203 0.9334136304694418 1.0 1.0 7 O00767,Q8NB78 2 Mitotic telophase cytokinesis 0.3587936865839942 0.0816196183275825 0.934949200175058 1.0 1.0 13 Q8WVM7,Q02241,Q7Z5K2,Q6KC79,Q29RF7,Q14683,Q9Y6X3,O95235,Q8N3U4,Q9UQE7,O60216,Q9NTI5 12 Activation of atr in response to replication stress 0.3725004649763744 0.0783337135122387 0.9375626003415404 1.0 1.0 23 P33991,P24941,Q9Y619,Q9UBD5 4 Sars cov 2 infection 0.3722866877950325 0.0777128280375718 0.9380564896697372 1.0 1.0 26 P27824,P49840,P48729,P04843,Q9H0U3,P46977,Q16706,P61803,Q10472 9 Pyruvate metabolism 0.3655490151288023 0.0753787953179068 0.9399133300881656 1.0 1.0 17 P21796,P35613 2 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.3680636821622641 0.0660644171318623 0.947326539952042 1.0 1.0 21 P16278,P10619,Q86YN1,Q9BT22 4 Ldl clearance 0.3473817225297206 0.0652457946769755 0.9479782999009494 1.0 1.0 11 O15118 1 Insulin receptor recycling 0.3429989653647559 0.0624809728247423 0.9501798138174788 1.0 1.0 10 Q93050 1 Anchoring of the basal body to the plasma membrane 0.3443286578672386 0.0542761163807397 0.9567151778653418 1.0 1.0 39 O75935,Q96CS2,O95684,O43805,Q9H6D7,P07437,P04350,O94927,P41208 9 Regulation of mecp2 expression and activity 0.3461016917435163 0.0526982919218717 0.957972299985366 1.0 1.0 12 Q14739,Q13555,Q96GD4 3 Synthesis of pips at the er membrane 0.3520748524471102 0.0498806313614036 0.9602175120220636 1.0 1.0 3 Q9NTJ5 1 Downregulation of erbb2 signaling 0.3261114237478965 0.0498480147012684 0.9602435040176064 1.0 1.0 7 Q9UNE7,P07900,Q16543,P40818,P31751,Q96RT1 6 Signaling by ptk6 0.3499433232236777 0.0470765324657847 0.9624522309751048 1.0 1.0 14 P04150,Q14185,P24941 3 Transferrin endocytosis and recycling 0.3406753726411486 0.0468145546848154 0.962661028791312 1.0 1.0 11 Q93050 1 Cell death signalling via nrage nrif and nade 0.3407513228663594 0.0379957268036372 0.9696910890864164 1.0 1.0 12 Q92542 1 Transport to the golgi and subsequent modification 0.2797748445765919 0.0275701859156233 0.9780049608151764 1.0 1.0 78 Q16706,P04066,P53634,Q13885,O75935,Q9Y3B3,Q9BVK6,Q9BUF5,P24390,P04350,Q96PC5,Q13813,Q15363,Q5JRA6,Q13509,Q12893,Q9BVA1,P68371,P49755 19 Phosphorylation of emi1 0.3086003372681356 0.0271644174982331 0.978328595949384 1.0 1.0 3 P06493,P53350 2 Sumoylation of ubiquitinylation proteins 0.3574441558880211 0.026132999252061 0.9791512564477352 1.0 1.0 30 Q92621,Q8TEM1,P37198,Q99567,Q9BW27,Q5SRE5,Q7Z3B4,A8CG34,P12270,P14373,Q8N1F7,Q9BTX1,O15504 13 Cd163 mediating an anti inflammatory response 0.3950547906715362 0.0236544125226652 0.9811282693568284 1.0 1.0 2 P35579 1 Atf6 atf6 alpha activates chaperones 0.3748243888732801 0.0212175599030857 0.9830721066584625 1.0 1.0 2 P14625 1 Atf6 atf6 alpha activates chaperone genes 0.3748243888732801 0.0212175599030857 0.9830721066584625 1.0 1.0 2 P14625 1 Regulation of tp53 expression and degradation 0.3302687878594379 0.0200623459560259 0.9839936376694748 1.0 1.0 11 P31751,P42345,P24941 3 Runx1 regulates expression of components of tight junctions 0.3506602978364649 0.0194718497594987 0.9844646934223352 1.0 1.0 2 Q07157 1 Aurka activation by tpx2 0.3406216664688073 0.0175756124654298 0.9859774121054954 1.0 1.0 38 O75935,Q96CS2,O95684,O43805,Q9H6D7,P07437,P04350,O94927,P41208 9 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.3056194555401914 0.0147415223475417 0.9882383929083788 1.0 1.0 5 Q8NB78 1 Sars cov infections 0.2657254332589042 0.0118277230515898 0.9905630624183124 1.0 1.0 67 P27824,P53680,P04150,P49840,P48729,P04843,P07437,Q99720,P46977,P05023,P21964,Q10472 12 Suppression of apoptosis 0.3016199286768949 0.0091576843876502 0.9926933271413388 1.0 1.0 5 P23246,P49840 2