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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:14eab90111c3c9813b208059826bd67629ffe972f9ffd7f42e758a2623a2b033
+size 76660

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3197,
+    "annotations_size": 54,
+    "title": "Average number of proteins per term",
+    "value": 2.611111111111111
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C089/C089_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,7 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.9602379461490284	1.6133016302194196	0.1066789925542353	0.9977384429919564	0.3200369776627059	3	Q9H3G5,Q9HB40	2
+Histidine acid phosphatase active site [IPR033379]	0.902034428794993	1.4597030106235556	0.1443717141337166	0.9997795057856774	0.3842560685531501	2	P11117	1
+Peptidase S9, serine active site [IPR002471]	0.7987480438184691	1.0407841424716435	0.2979757413120245	0.999999994953219	0.6029738129571183	2	P13798	1
+Nucleoside diphosphate kinase, active site [IPR023005]	0.6197183098591448	0.3973670258937514	0.6910968276033844	1.0	0.8293161931240612	2	P15531	1
+Cysteine peptidase, cysteine active site [IPR000169]	0.4487942373943147	0.2186884776230901	0.8268927252697578	1.0	0.9112695339707534	4	Q13867,P17655,P53634	3
+Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]	0.3556585983120159	0.0108014578570385	0.9913818511240796	1.0	0.9913818511240796	3	P00390	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CASP2", "CDK1", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "JAK1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MDH1", "MDH2", "MTMR14", "NCEH1", "NEK9", "NME1", "NME2", "PAK1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRKCA", "PRKCD", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "RIPK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TRIO", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "VRK2"], "leading_proteins": ["ACP2", "APEH", "BLMH", "CAPN2", "CPVL", "CTSC", "GSR", "NME1", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:c8134c3982bb4cef7ee4b73090806072df6c835a68a93143812c10f2a9c5415b
+size 73125

interpro_binding_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+EF-Hand 1, calcium-binding site [IPR018247]	11	36	2.1050116167285817	0.035290296869805	10.019417475728156	36.70631067961165	0.9532938980945532	0.3894555773109194	3.76037227687173	3.057484685571999	1.1082350706804749	0.3408841825650379	0.3067821418395792	0.0551599902794207	0.175896893635733	0.1246036458142231	0.0014520664325667

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3197,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.483870967741935
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C089/C089_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-Hand 1, calcium-binding site [IPR018247]	0.494956790333818	2.1050116167285817	0.035290296869805	0.6716809758955706	0.2007782720967907	36	O75340,Q96AY3,Q9BPX6,Q9H4M9,Q14257,P19174,P80303,Q9Y680,P41208,Q02818,O43852	11
+Beta tubulin, autoregulation binding site [IPR013838]	0.8813028499843301	1.828287779132235	0.0675063729643703	0.8854428913394375	0.2989567945564972	4	Q13885,P04350,P07437	3
+Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]	0.6841940532081167	0.6067164876542569	0.5440390783848792	0.9999999999732848	0.7101120318897071	2	P34896	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKA", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK13", "CDK2", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "JAK1", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MCCC1", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXSR1", "PA2G4", "PAK1", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKACA", "PRKCA", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "RHOT1", "RHOT2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK4", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB4A", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "CETN2", "EHD1", "FKBP10", "FKBP7", "MICU1", "NUCB1", "NUCB2", "PDCD6", "PLCG1", "RCN2", "SHMT1", "TUBB", "TUBB2A", "TUBB4A"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:93dc781df62a24e1a0e92e3409963bbde7dfaee9fdbdc03953ab3cb6c9b7f87b
+size 94225

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	6	8	2.70978058666615	0.0067327730797801	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	0.0009141595337786	0.0009934566258862	0.0039135152062846	1.828578586842436e-06	6.532965724760314e-08

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3197,
+    "annotations_size": 279,
+    "title": "Average number of proteins per term",
+    "value": 2.6594982078853047
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C089/C089_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,33 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.8947212594692338	2.70978058666615	0.0067327730797801	0.848139931533001	0.1312430142345431	8	P20618,P28072,P49720,P28070,P49721,P28074	6
+Tubulin, conserved site [IPR017975]	0.8813028499843301	1.828287779132235	0.0675063729643703	0.9999999966021954	0.2840433549773424	4	Q13885,P04350,P07437	3
+Haem oxygenase conserved site [IPR018207]	0.987167449139278	1.8068892537028611	0.0707795484287365	0.999999998726104	0.2848093784868222	2	P30519	1
+Thioredoxin, conserved site [IPR017937]	0.6018692767465114	1.6019326432464658	0.1091705050610074	0.99999999999999	0.3583361283767186	11	O95881,Q96JJ7,O43396	3
+Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]	0.7359315878917132	1.5214945842097616	0.1281357693660667	1.0	0.3885856484036154	5	P48735	1
+Tetraspanin, conserved site [IPR018503]	0.8967272852200703	1.375289340719688	0.169041759824482	1.0	0.4556898817065573	3	O43657	1
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.7518993509086559	1.3115277687940454	0.1896795183506918	1.0	0.4645689775727784	4	Q8N4Q0	1
+Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]	0.8341158059467741	1.1829623006439745	0.2368240887195685	1.0	0.5168152327715234	2	Q14155	1
+Sterol reductase, conserved site [IPR018083]	0.8244131455398968	1.1437568547268342	0.2527244874583938	1.0	0.5168152327715234	2	Q9UBM7	1
+C-type lectin, conserved site [IPR018378]	0.7968701095461419	1.0332995484920064	0.3014637385029688	1.0	0.5391563015533866	2	Q9UBG0	1
+Guanylate kinase, conserved site [IPR020590]	0.6208674752382425	1.0254918814494354	0.3051311541658457	1.0	0.5422394395686048	5	Q14168,Q9NZW5	2
+Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]	0.7954891831373843	0.9979374878478504	0.3183096723146612	1.0	0.5585433872691224	3	Q9H3P7	1
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.7226917057902802	0.7460948168123401	0.4556101401643804	1.0	0.7148968568649477	2	P04439	1
+EGF-like calcium-binding, conserved site [IPR018097]	0.7070422535211314	0.6884069533394844	0.4911965463238164	1.0	0.7306045974796302	2	P01130	1
+ABC transporter-like, conserved site [IPR017871]	0.4113597815851604	0.6005305308489757	0.5481527199220495	1.0	0.7685156224032755	12	P08183	1
+Intermediate filament protein, conserved site [IPR018039]	0.464008179608635	0.5911007501147004	0.5544529173036419	1.0	0.7708998620334767	7	P07196,P08670	2
+Actin, conserved site [IPR004001]	0.6719874804381902	0.5644855339198639	0.5724237424506102	1.0	0.7752729327365061	2	O96019	1
+Ribosomal protein S2, conserved site [IPR018130]	0.6491392801252016	0.4884851804080716	0.6252062201683863	1.0	0.7884317299369284	2	Q9Y399	1
+DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]	0.6482003129890513	0.4854540783709924	0.6273542797347602	1.0	0.7884317299369284	2	P19387	1
+Profilin conserved site [IPR027310]	0.633176838810648	0.4380308979909134	0.6613638854429189	1.0	0.8164624957459043	2	P35080	1
+Adenylate kinase, conserved site [IPR033690]	0.461282151512251	0.3852482732589445	0.7000534812845567	1.0	0.8382614647141258	5	P30085	1
+NUDIX hydrolase, conserved site [IPR020084]	0.5984350547730901	0.3368949933275162	0.7361960596767347	1.0	0.8558279193742041	2	Q9UKK9	1
+Ribosomal protein S5, N-terminal, conserved site [IPR018192]	0.5715179968701126	0.267790075617397	0.7888609103315385	1.0	0.8910615140991872	2	P15880	1
+Annexin repeat, conserved site [IPR018252]	0.3924845537099746	0.2451822992366512	0.8063152813377932	1.0	0.9010147744679996	6	P04083	1
+14-3-3 protein, conserved site [IPR023409]	0.3861957642764095	0.2249100938821724	0.8220492166768738	1.0	0.9065285828175802	6	P31946,P27348	2
+Chromo domain, conserved site [IPR023779]	0.4085213032581569	0.2183500010531056	0.8271564189656222	1.0	0.9085694523283804	5	Q13185,P83916,O14646,P45973	4
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.5156543519098389	0.1616386314455223	0.8715904338275402	1.0	0.9426569642743748	3	Q9Y2T2,Q96CW1	2
+Mrp, conserved site [IPR000808]	0.4978083907326327	0.1315519079664718	0.8953387266988639	1.0	0.946035936201454	3	P53384,Q8TB37	2
+Ubiquitin specific protease, conserved site [IPR018200]	0.3011058731010633	0.0741505348788914	0.9408906048839608	1.0	0.9654060178237424	11	P51784,Q70CQ2	2
+Heat shock protein Hsp90, conserved site [IPR019805]	0.444583594239201	0.0635483878830913	0.94932982911996	1.0	0.9701942209687502	3	P07900,P08238	2
+Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]	0.4159624413145639	0.0467037333312575	0.9627493548266824	1.0	0.9788164536156656	2	P13995	1
+Calreticulin/calnexin, conserved site [IPR018124]	0.3603631809643015	0.0121814639208676	0.9902808383780852	1.0	0.9974308805324396	3	P27797,O14967	2

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Connexin, conserved site [IPR017990]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Di-trans-poly-cis-decaprenylcistransferase-like, conserved site [IPR018520]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "Ribosome-binding factor A, conserved site [IPR020053]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Uncharacterised protein family UPF0029, Impact, conserved site [IPR020569]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCB8", "ABCC1", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ACY1", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANKRD13A", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "ARHGEF7", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX2", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC27", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHDDS", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB4", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DRG1", "DRG2", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GJA1", "GLA", "GLB1", "GLO1", "GMPPA", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPACT", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "ING5", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF1B", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MID1", "MIF", "MKRN2", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NUBP1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL2", "OSBPL8", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP7", "RBFA", "RCL1", "RDH13", "RDX", "RIDA", "RNF2", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCAP", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC25A42", "SLC27A2", "SLC27A4", "SLC2A4", "SLC4A2", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STRN4", "STX10", "STX12", "STX18", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAF5", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMBIM6", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM13", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB4A", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP34", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ACBD3", "ACTL6A", "ANXA1", "AP2M1", "AP3M1", "ARHGEF7", "CALR", "CBX1", "CBX3", "CBX5", "CHD1", "CLGN", "CMPK1", "DHCR7", "HLA-A", "HMOX2", "HSP90AA1", "HSP90AB1", "IDH2", "LDLR", "MPP2", "MPP6", "MRC2", "MRPS2", "MTHFD2", "NEFL", "NUBP1", "NUBPL", "NUDT5", "PFN2", "POLR2C", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "RPS2", "TMX3", "TSPAN6", "TUBB", "TUBB2A", "TUBB4A", "TXNDC12", "TXNL1", "USP11", "USP34", "VIM", "YWHAB", "YWHAQ", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "K Homology domain, type 1 [IPR004088]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "K Homology domain, type 1 [IPR004088]", "1": "EF-hand domain [IPR002048]", "2": "K Homology domain [IPR004087]", "3": "CS domain [IPR007052]", "4": "Importin-beta, N-terminal domain [IPR001494]", "5": "RNA recognition motif domain, eukaryote [IPR003954]", "6": "Thioredoxin domain [IPR013766]", "7": "PDZ domain [IPR001478]", "8": "SH2 domain [IPR000980]", "9": "MIF4G-like, type 3 [IPR003890]", "10": "Pleckstrin homology domain [IPR001849]", "11": "RNA recognition motif domain [IPR000504]", "12": "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "13": "CBS domain [IPR000644]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:2d5bba19b0eebb8820cee6cd30a4c7ab005b8b626f531c76d07b9b5c065b3bff
+size 319456

interpro_domain/df_merge.tsv

@@ -0,0 +1,4 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	3	6	2.081774043314051	0.0373631137321042	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0362999537782941	0.0378187125466048	0.002465796513642	0.0007187465088185	0.0003311660608568
+Aminopeptidase N-like , N-terminal domain [IPR045357]	3	6	2.081774043314051	0.0373631137321042	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0362999537782941	0.0378187125466048	0.002465796513642	0.0007187465088185	0.0003311660608568
+K Homology domain, type 1 [IPR004088]	10	22	2.008504848676216	0.0445896713273865	8.5	23.218446601941743	0.4539576731478794	0.576935027430011	4.690674491420825	1.6401661988255969	0.9187340965418598	0.3398774289684012	1.0	1.0	1.0	0.1988041978590851	0.0054053690368969

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3197,
+    "annotations_size": 2586,
+    "title": "Average number of proteins per term",
+    "value": 2.1759474091260635
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C089/C089_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,193 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8154435135496073	2.081774043314051	0.0373631137321042	1.0	0.1880493922907848	6	Q9UIQ6,P55786,Q6P179	3
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8154435135496073	2.081774043314051	0.0373631137321042	1.0	0.1880493922907848	6	Q9UIQ6,P55786,Q6P179	3
+K Homology domain, type 1 [IPR004088]	0.546185422267293	2.008504848676216	0.0445896713273865	1.0	0.2055416934984343	22	Q96AE4,Q96PU8,P61978,Q96I24,Q9Y6M1,P51116,Q15365,P51114,Q92945,Q15366	10
+Major facilitator superfamily domain [IPR020846]	0.8910502101045468	1.8665476688113336	0.0619647813247907	1.0	0.2480509667274132	4	Q9H2V7,Q7L0J3	2
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.8813028499843301	1.828287779132235	0.0675063729643703	1.0	0.2601661408135047	4	Q13885,P04350,P07437	3
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.8813028499843301	1.828287779132235	0.0675063729643703	1.0	0.2601661408135047	4	Q13885,P04350,P07437	3
+EF-hand domain [IPR002048]	0.4727936885642734	1.8258721085432272	0.0678695283707664	1.0	0.2604283245005111	44	O75340,Q96AY3,Q9BPX6,Q9H4M9,Q14257,P19174,O75071,P80303,Q9Y680,P41208,Q02818,O43852	12
+Reticulon [IPR003388]	0.8800501096147751	1.8233620907772323	0.0682485679342586	1.0	0.2614678469303595	4	O95197,O75298,Q9NQC3	3
+ERAP1-like C-terminal domain [IPR024571]	0.8725336673974186	1.7937681954835658	0.0728501753108223	1.0	0.2707898526183937	4	P55786,Q9UIQ6,Q6P179	3
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.7404390871437049	1.7526574031077926	0.0796608316109228	1.0	0.2861151535358979	6	Q8WUJ1,Q9UMX5,O43169,O15173	4
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.7310020399076544	1.7105247152309162	0.0871688871388971	1.0	0.296009823704969	6	O15460,Q32P28	2
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.7310020399076544	1.7105247152309162	0.0871688871388971	1.0	0.296009823704969	6	O15460,Q32P28	2
+Prenylcysteine lyase [IPR010795]	0.9461658841940496	1.640038710476496	0.1009971184366183	1.0	0.3152574539890432	2	Q9UHG3	1
+Proteasome alpha-subunit, N-terminal domain [IPR000426]	0.6833225278809062	1.6262941252963925	0.1038871009108524	1.0	0.3178807677181529	7	P60900	1
+Fatty acid hydroxylase [IPR006694]	0.9361502347417788	1.5991518301640315	0.1097868705195277	1.0	0.3274498040573938	2	Q15800	1
+FAD dependent oxidoreductase [IPR006076]	0.8152440577478784	1.5661754433947803	0.1173075499561813	1.0	0.3374386253467017	4	Q9H9P8	1
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.9173708920187796	1.522409872305997	0.1279064127022739	1.0	0.3548833357986073	2	Q14011	1
+Isopropylmalate dehydrogenase-like domain [IPR024084]	0.7359315878917132	1.5214945842097616	0.1281357693660667	1.0	0.3548833357986073	5	P48735	1
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.7215590164746303	1.4598277739651675	0.1443374132944077	1.0	0.3779567957141561	5	Q8N4Q0	1
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.9189104571070752	1.4585339044921342	0.1446934368743289	1.0	0.3779567957141561	3	Q9Y282,Q96RQ1	2
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.9189104571070752	1.4585339044921342	0.1446934368743289	1.0	0.3779567957141561	3	Q9Y282,Q96RQ1	2
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.8995305164319256	1.449465518681804	0.1472076230482151	1.0	0.3806785823508057	2	O15027	1
+IMD/I-BAR domain [IPR013606]	0.8989045383411425	1.446906239937809	0.1479231852525138	1.0	0.3806785823508057	2	Q9UQB8	1
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.8982785602503918	1.4443470055078524	0.1486413896613929	1.0	0.3817146312456426	2	O15254	1
+RBM1CTR [IPR012604]	0.8964006259780917	1.436669601560535	0.1508118964071516	1.0	0.384236023752605	2	Q96E39	1
+Phospholipase D/Transphosphatidylase [IPR001736]	0.8926447574334772	1.421316445995226	0.1552247845276135	1.0	0.3904287618821679	2	Q8IV08	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.8876369327073563	1.400850099733716	0.1612589033656377	1.0	0.3982956295162743	2	O60506	1
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.769808957093641	1.3837135651430703	0.1664461782534112	1.0	0.4047094673614637	4	Q4J6C6,P48147,P13798	3
+K Homology domain [IPR004087]	0.4604843456369509	1.3820086010664638	0.1669690601870757	1.0	0.4050487707727746	22	Q96AE4,Q96PU8,P61978,Q96I24,Q9Y6M1,P51116,Q15365,P51114,Q92945,Q15366	10
+BRICHOS domain [IPR007084]	0.8744913928012359	1.3471634786222246	0.1779275874182744	1.0	0.4175715284746202	2	Q9Y287	1
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.8738654147104712	1.3446087469122028	0.1787516171776506	1.0	0.4175715284746202	2	O15460	1
+CS domain [IPR007052]	0.5859095134207526	1.3375020502706585	0.1810588134789064	1.0	0.4193520730478343	9	Q9HB71,Q9UHD1,Q96RS6,Q9Y266,Q8IVD9,Q15185	6
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.8741390106449455	1.2905480304755397	0.196860446708825	1.0	0.4373283192396578	3	O15460,Q32P28	2
+Far upstream element-binding protein, C-terminal [IPR015096]	0.8588419405320704	1.2833622373774385	0.1993651973792398	1.0	0.4406482054894993	2	Q92945	1
+Importin-beta, N-terminal domain [IPR001494]	0.516084762323187	1.2631210663291	0.2065456742642468	1.0	0.4508122034064261	13	O00410,O14980,Q14974,O95373,Q96P70,Q8TEX9,Q92973,Q9HAV4	8
+FAD-binding domain, PCMH-type [IPR016166]	0.8535211267605481	1.2617083189730482	0.2070537623530155	1.0	0.4510876406443961	2	Q15392	1
+FAD linked oxidase, N-terminal [IPR006094]	0.8535211267605481	1.2617083189730482	0.2070537623530155	1.0	0.4510876406443961	2	Q15392	1
+CARG-binding factor, N-terminal [IPR012956]	0.8469483568074945	1.234993008054305	0.2168331063450606	1.0	0.463467757404279	2	Q99729	1
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.577344000384428	1.2180683979083438	0.2231979818252842	1.0	0.4715604419936153	8	Q9H5K3,Q13546	2
+Ricin B, lectin domain [IPR000772]	0.6197480651460135	1.2049124803175264	0.2282370901286508	1.0	0.4773792522312687	6	Q9UBG0	1
+RNA recognition motif domain, eukaryote [IPR003954]	0.5045980969218503	1.1952602957399785	0.2319853472249426	1.0	0.4780192095009575	13	Q9UHX1,Q96E39,P31483,P38159,Q14011	5
+Thioredoxin domain [IPR013766]	0.4268038868575352	1.1828435475874652	0.2368711582163856	1.0	0.4853794097841308	26	Q9Y2G8,Q96J42,O43396,Q96JJ7,O95881	5
+G-protein gamma-like domain [IPR015898]	0.8322378716744758	1.1753642874426546	0.239849004777672	1.0	0.4895418518982319	2	P63218	1
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.8410826050968894	1.1668786017997497	0.2432593984971731	1.0	0.4937917190353935	3	Q15629	1
+Arfaptin homology (AH) domain [IPR010504]	0.818779342723007	1.1210549221031771	0.262264484929549	1.0	0.5126784965749239	2	P53365	1
+VHS domain [IPR002014]	0.8172143974960899	1.114757743188581	0.2649542490909771	1.0	0.515026781580336	2	O14964	1
+Peptidase M16, N-terminal [IPR011765]	0.5740397430340781	1.1063035207644891	0.2685951684157497	1.0	0.5179620473699692	7	Q5JRX3,Q10713	2
+Peptidase M16, C-terminal [IPR007863]	0.5740397430340781	1.1063035207644891	0.2685951684157497	1.0	0.5179620473699692	7	Q5JRX3,Q10713	2
+UBX domain [IPR001012]	0.6990197412893471	1.098535763845268	0.2719706097880534	1.0	0.5213610058650157	4	Q96CS3,Q9UNN5	2
+TGS [IPR004095]	0.595517116012855	1.093745445726512	0.274066636581745	1.0	0.5239145894832355	6	P55039	1
+UAS [IPR006577]	0.810641627543016	1.0883549834263997	0.2764384261059023	1.0	0.5247909145821407	2	Q9UNN5	1
+Phospholipid/glycerol acyltransferase [IPR002123]	0.5508379802197759	1.0858517422267209	0.2775445901412134	1.0	0.5250228957081	8	Q9HCL2,Q86UL3	2
+EB1, C-terminal [IPR004953]	0.8078247261345872	1.077063205436302	0.2814520296172433	1.0	0.5289976754706677	2	Q15555	1
+YTH domain [IPR007275]	0.8053208137715206	1.0670386988754512	0.2859543612426085	1.0	0.5324505047213296	2	Q96MU7	1
+Mab-21 domain [IPR024810]	0.8018779342722784	1.053275220555455	0.292214872306282	1.0	0.5380515368546419	2	Q9NQG6	1
+PDZ domain [IPR001478]	0.4163442905744076	1.0502497236235198	0.2936033138020397	1.0	0.5400129228250888	22	O14936,Q92614,Q96L92,Q9NR12,P57105,Q14168,Q9NZW5,Q9HD26	8
+Peptidase S9A, N-terminal domain [IPR023302]	0.7987480438184693	1.0407841424716424	0.297975741312025	1.0	0.5434169725196732	2	Q4J6C6	1
+CD209-like, C-type lectin-like domain [IPR033989]	0.7968701095461419	1.0332995484920064	0.3014637385029688	1.0	0.5463106010992833	2	Q9UBG0	1
+C-type lectin-like [IPR001304]	0.7968701095461419	1.0332995484920064	0.3014637385029688	1.0	0.5463106010992833	2	Q9UBG0	1
+NudC N-terminal domain [IPR025934]	0.7921752738654179	1.01462248586361	0.3102858165041089	1.0	0.5537606083365256	2	Q8IVD9	1
+Exportin-1/Importin-beta-like [IPR013598]	0.6770389082142083	1.0105400810649976	0.3122366065911035	1.0	0.5549442368691366	4	Q9Y5L0,Q9HAV4	2
+Glutathione S-transferase, N-terminal [IPR004045]	0.5332055917136183	0.9980257052469248	0.3182668940890467	1.0	0.55759707098193	8	P78417,P21266,Q9H7Z7	3
+Acyl-CoA-binding protein, ACBP [IPR000582]	0.7954891831373843	0.9979374878478504	0.3183096723146612	1.0	0.55759707098193	3	Q9H3P7	1
+Histone-binding protein RBBP4, N-terminal [IPR022052]	0.7837245696400659	0.9811359465128988	0.3265257060069064	1.0	0.5651910814818341	2	Q16576	1
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.7821596244131241	0.9749545561148132	0.3295828023289013	1.0	0.5687020948436585	2	P51114	1
+L27 domain, C-terminal [IPR014775]	0.6672780491644132	0.9716674659798554	0.3312160070603258	1.0	0.568741430450201	4	Q14168,Q9NZW5	2
+L27 domain [IPR004172]	0.6672780491644132	0.9716674659798554	0.3312160070603258	1.0	0.568741430450201	4	Q14168,Q9NZW5	2
+Zinc finger, CHHC-type [IPR012996]	0.7874139010644835	0.9683332421266936	0.3328779680116116	1.0	0.5697037890655379	3	P52597,P31943	2
+Glutathione S-transferase, C-terminal-like [IPR010987]	0.4760805155013989	0.9632930114759348	0.335400499417178	1.0	0.5732621886932071	12	P78417,P21266,Q9H7Z7	3
+Domain of unknown function DUF3517 [IPR021905]	0.7842830306825216	0.9568885218055632	0.338623525285566	1.0	0.5768645826011026	3	Q9UPU5,Q70CQ2	2
+MIT domain [IPR007330]	0.7737089201877968	0.9416903268712372	0.3463512089072091	1.0	0.5828663136514352	2	Q8N0X7	1
+PB1 domain [IPR000270]	0.7690140845070341	0.9232992278843226	0.3558512901526622	1.0	0.5911694454711846	2	Q92734	1
+Guanylate kinase-like domain [IPR008144]	0.528606313488752	0.8896195993440819	0.3736701786092442	1.0	0.6032939949503981	7	O14936,Q14168,Q9NZW5	3
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.528606313488752	0.8896195993440819	0.3736701786092442	1.0	0.6032939949503981	7	O14936,Q14168,Q9NZW5	3
+FAD/NAD(P)-binding domain [IPR023753]	0.5417208455273848	0.8488353265630625	0.3959729299452403	1.0	0.6175324246462592	6	P00390,Q9Y6N5,O95831	3
+ZU5 domain [IPR000906]	0.7408450704225393	0.8145118914481573	0.4153517627253156	1.0	0.6321952080092208	2	Q12955	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.6266109173842742	0.8117866984504472	0.4169140358705467	1.0	0.6338269822229475	4	P07196,P08670	2
+Zinc finger, RanBP2-type [IPR001876]	0.4793745635781527	0.7896169593535908	0.4297515008039858	1.0	0.6444186714639105	9	Q92804,P35637	2
+ABC transporter type 1, transmembrane domain [IPR011527]	0.4895250652619784	0.7826070460423448	0.4338579025575912	1.0	0.6492804027858398	8	P08183	1
+Immunoglobulin C1-set [IPR003597]	0.7346393145287037	0.7785987604752292	0.4362161094763528	1.0	0.6505506684578133	3	P10321	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.7346393145287037	0.7785987604752292	0.4362161094763528	1.0	0.6505506684578133	3	P10321	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.7346393145287037	0.7785987604752292	0.4362161094763528	1.0	0.6505506684578133	3	P10321	1
+MHC class I-like antigen recognition-like [IPR011161]	0.7346393145287037	0.7785987604752292	0.4362161094763528	1.0	0.6505506684578133	3	P10321	1
+Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]	0.7198748043818511	0.7356170613698941	0.461963776517952	1.0	0.6745558024141298	2	Q9NRG0	1
+Agenet-like domain [IPR008395]	0.7166542658728651	0.7159118092688463	0.4740458060605026	1.0	0.6806676593406218	3	P51114	1
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.7166542658728651	0.7159118092688463	0.4740458060605026	1.0	0.6806676593406218	3	P51114	1
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.7166542658728651	0.7159118092688463	0.4740458060605026	1.0	0.6806676593406218	3	P51114	1
+Fxr1, tudor domain [IPR041560]	0.7166542658728651	0.7159118092688463	0.4740458060605026	1.0	0.6806676593406218	3	P51114	1
+BRO1 domain [IPR004328]	0.7133020344287996	0.7113263903351795	0.4768820016689044	1.0	0.6831739203426668	2	Q5VW32	1
+SH2 domain [IPR000980]	0.4633647726997424	0.7091336863700997	0.4782415202653287	1.0	0.6836553739116308	9	P62993,P19174,Q06124,P23458,P46109	5
+BSD domain [IPR005607]	0.7123630672926493	0.707874840871097	0.4790229848079979	1.0	0.6843941650350732	2	P32780	1
+EGF-like calcium-binding domain [IPR001881]	0.7070422535211314	0.6884069533394844	0.4911965463238164	1.0	0.6936074013031903	2	P01130	1
+N-acetylgalactosaminyltransferase [IPR045885]	0.5884747886000512	0.6665098577916068	0.5050852648949995	1.0	0.7041242560746462	4	Q86SF2,Q8N4A0,Q10471	3
+Serine hydroxymethyltransferase-like domain [IPR039429]	0.6841940532081167	0.6067164876542569	0.5440390783848792	1.0	0.7337148439163447	2	P34896	1
+ABC transporter-like, ATP-binding domain [IPR003439]	0.4113597815851604	0.6005305308489757	0.5481527199220495	1.0	0.7352297374058195	12	P08183	1
+Intermediate filament, rod domain [IPR039008]	0.464008179608635	0.5911007501147004	0.5544529173036419	1.0	0.7396920594421967	7	P07196,P08670	2
+Exosome complex component, N-terminal domain [IPR025721]	0.6794992175273917	0.5903491311926127	0.5549566068491991	1.0	0.73975143572785	2	Q13868	1
+OBG-type guanine nucleotide-binding (G) domain [IPR031167]	0.513564498434836	0.5796013392856948	0.5621834896680256	1.0	0.7459243223609616	5	P55039	1
+LEM domain [IPR003887]	0.4797648008706829	0.5774171677430814	0.5636576795949717	1.0	0.747496799709024	6	P50402,Q8NC56,Q86XL3	3
+Peptidase M16, middle/third domain [IPR032632]	0.6754303599374076	0.5762890818379088	0.5644198014322992	1.0	0.7475480414122103	2	O43847	1
+Cold shock domain [IPR011129]	0.671348433712255	0.5643687407077125	0.572503208080827	1.0	0.7483209646721146	3	P67809	1
+Cold-shock protein, DNA-binding [IPR002059]	0.671348433712255	0.5643687407077125	0.572503208080827	1.0	0.7483209646721146	3	P67809	1
+Cold-shock (CSD) domain [IPR019844]	0.671348433712255	0.5643687407077125	0.572503208080827	1.0	0.7483209646721146	3	P67809	1
+OCRE domain [IPR041591]	0.6632237871674547	0.5348419612711096	0.5927591444040294	1.0	0.7557779544952804	2	P52756	1
+Ubiquitin-associated domain [IPR015940]	0.3760346824400413	0.5298652703970064	0.5962053469336319	1.0	0.7557779544952804	16	Q9BSL1,Q14157,Q8NBM4	3
+Glutathione S-transferase, C-terminal [IPR004046]	0.4102272086163876	0.4985350003128032	0.6181070061677523	1.0	0.7710683636998589	10	P78417,P21266	2
+Peptidase M28 [IPR007484]	0.6499686912961825	0.4968357745427245	0.6193048652944482	1.0	0.7721901550874846	3	Q7Z2K6,Q969V3	2
+GNAT domain [IPR000182]	0.4901145426369633	0.4896014943409527	0.6244159188248972	1.0	0.7770893783731347	5	Q86UY6	1
+DNA-directed RNA polymerase, insert domain [IPR011262]	0.6482003129890513	0.4854540783709924	0.6273542797347602	1.0	0.7781476193562347	2	P19387	1
+DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]	0.6482003129890513	0.4854540783709924	0.6273542797347602	1.0	0.7781476193562347	2	P19387	1
+CNNM, transmembrane domain [IPR002550]	0.641627543036	0.4644537832913534	0.6423226644014306	1.0	0.783882213375224	2	Q6P4Q7	1
+Ion transporter-like, CBS domain [IPR044751]	0.641627543036	0.4644537832913534	0.6423226644014306	1.0	0.783882213375224	2	Q6P4Q7	1
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.4022611009241966	0.4599740964522695	0.6455348136750354	1.0	0.7843454864849846	10	Q9NWM8,Q96AY3,Q9Y680,O00170	4
+Polyketide synthase, enoylreductase domain [IPR020843]	0.4480517331882532	0.4475216712899786	0.6544984442379667	1.0	0.7873696758962326	6	Q8N4Q0	1
+Syntaxin, N-terminal domain [IPR006011]	0.6347417840375651	0.4428736943243777	0.6578570955595047	1.0	0.7895832895226903	2	Q86Y82	1
+Mu homology domain [IPR028565]	0.515815847165686	0.4117416329846315	0.6805288061456412	1.0	0.8028501335276588	4	Q9Y2T2,Q96CW1,P48444	3
+Nucleoside diphosphate kinase-like domain [IPR034907]	0.6197183098591448	0.3973670258937514	0.6910968276033844	1.0	0.8090431852342019	2	P15531	1
+SH3 domain [IPR001452]	0.3105290441951289	0.3923578995919543	0.6947937884587316	1.0	0.811454745358173	34	Q14155,Q15642,Q14168,Q9UQB8	4
+Alpha/beta hydrolase fold-1 [IPR000073]	0.4332914292043592	0.3901812739038364	0.6964025077055882	1.0	0.8122439929819106	6	P07099	1
+NUDIX hydrolase [IPR020476]	0.5984350547730901	0.3368949933275162	0.7361960596767347	1.0	0.8405311303858879	2	Q9UKK9	1
+MIF4G-like, type 3 [IPR003890]	0.4186775305546908	0.3357812946173416	0.737035796766297	1.0	0.8408032880968929	6	Q09161,O43432,Q04637,P78344,Q9HAU5	5
+Septin-type guanine nucleotide-binding (G) domain [IPR030379]	0.4449673638117718	0.32995146190912	0.7414366378595498	1.0	0.8431640921305171	5	Q16181	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.5885834002975164	0.3219395314013114	0.7474985044309823	1.0	0.8475217141941384	3	O43823	1
+Dbl homology (DH) domain [IPR000219]	0.4854183480187725	0.317998201029705	0.7504863015093708	1.0	0.849346860263997	4	Q14155	1
+Pleckstrin homology domain [IPR001849]	0.3119694012252665	0.3014353392088206	0.7630825499138791	1.0	0.8617168009071142	22	Q96TA1,Q14155,Q9BXB4,P19174,P31751,O15020	6
+RNA recognition motif domain [IPR000504]	0.3278986352904094	0.3007591213356361	0.7635981823511162	1.0	0.8619226973199418	116	Q8WUA2,P35637,Q16630,Q01844,P98179,Q99729,P26368,O14979,Q12849,Q9BWF3,P51991,Q96E39,Q15056,P55795,P62995,Q96DH6,Q13151,Q14011,Q9GZT3,P31942,Q07955,P52597,O43719,P31483,Q8WVV9,P38159,Q96PK6,Q9Y6M1,Q01085,Q9UHX1,O60506,Q92804,P31943,O43390,Q14103,P22626,A0AV96	37
+Ribosomal protein S5, C-terminal [IPR005324]	0.5715179968701126	0.267790075617397	0.7888609103315385	1.0	0.8789290452896849	2	P15880	1
+Ribosomal protein S5, N-terminal [IPR013810]	0.5715179968701126	0.267790075617397	0.7888609103315385	1.0	0.8789290452896849	2	P15880	1
+Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]	0.570579029733967	0.2655373566641081	0.7905955359227432	1.0	0.8801033387413749	2	Q9Y237	1
+Exportin-2, central domain [IPR013713]	0.55945081473072	0.2509989772259646	0.8018148999386003	1.0	0.8886654961345704	3	O95373	1
+Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]	0.3530856077295574	0.2403127569287108	0.8100878061437147	1.0	0.8927350963101159	10	O15254,P16219,Q15067,Q9H845	4
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.4523295917178858	0.2275526153186542	0.8199940609813647	1.0	0.9000444149820922	4	Q16134	1
+14-3-3 domain [IPR023410]	0.3861957642764095	0.2249100938821724	0.8220492166768738	1.0	0.9007560630022544	6	P31946,P27348	2
+Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]	0.3816985271074921	0.2107933943102872	0.8330484933125455	1.0	0.9089719002979928	6	P49959,O00743,Q08209,P53041,P62136	5
+Potentiating neddylation domain [IPR005176]	0.5296021773374769	0.1877346141593103	0.8510846945053576	1.0	0.92067966179083	3	Q92564	1
+GTP binding domain [IPR006073]	0.3187977173074243	0.1778083064108765	0.8588735237310572	1.0	0.9251026650164538	13	Q9BT17,P55039	2
+ABC-transporter extension domain [IPR032781]	0.5283255086072074	0.1758498906213328	0.8604118732538821	1.0	0.926321858548934	2	Q9UG63	1
+PABP, RNA recognition motif 2 [IPR045305]	0.5248826291079894	0.1695723032581039	0.8653465058507792	1.0	0.9302790388158418	2	Q13310	1
+Zinc finger, UBP-type [IPR001607]	0.5201877934272388	0.1612649385632591	0.8718847367519134	1.0	0.9340074271915692	2	P45974	1
+NOPS [IPR012975]	0.5118973074514748	0.1549954465903119	0.8768249070205867	1.0	0.938522023822532	3	P23246,Q8WXF1	2
+Initiation factor eIF-4 gamma, MA3 [IPR003891]	0.4184152834325151	0.1494290524747774	0.881215088519977	1.0	0.9428308725331652	4	O43432,P78344,Q04637	3
+Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]	0.3815789473684298	0.148145211736928	0.882228169270665	1.0	0.943145071022669	5	O00743,Q08209,P53041,P62136	4
+Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]	0.5101721439749698	0.1445162868757626	0.8850927963837791	1.0	0.9452668783912284	2	P46926	1
+Heat shock protein Hsp90, N-terminal [IPR020575]	0.4099592859380061	0.1324329213480703	0.8946418765231385	1.0	0.9510348170760112	4	P14625,P07900,P08238	3
+Tudor domain [IPR002999]	0.3421525001464347	0.1015358925554818	0.9191250666351498	1.0	0.968868372394276	6	O75940	1
+Zinc finger, CCHC-type [IPR001878]	0.3573172254008731	0.0949171886253433	0.9243806036107822	1.0	0.9725175919192364	5	Q9NUD5	1
+HECT domain [IPR000569]	0.3256906189472102	0.0846009371279776	0.9325786540205804	1.0	0.9795484968713324	7	Q96PU5,Q7Z6Z7	2
+CBS domain [IPR000644]	0.3253918495297853	0.0838479641098081	0.9331773124133582	1.0	0.9797793462854018	7	P54619,P51798,Q6P4Q7,P51790,P12268,Q8NE01	6
+Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]	0.2982988816500184	0.079089136319216	0.9369617244071498	1.0	0.9807922044026032	12	P51784,Q70CQ2	2
+Ubiquitin specific protease domain [IPR028889]	0.2982988816500184	0.079089136319216	0.9369617244071498	1.0	0.9807922044026032	12	P51784,Q70CQ2	2
+Zinc finger, ZZ-type [IPR000433]	0.3789539617914344	0.0788666108017937	0.937138721210656	1.0	0.9807922044026032	4	Q13501,O43149,Q9Y4J8	3
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]	0.456338028169024	0.0764041844075847	0.9390975406632908	1.0	0.9808183522436472	2	Q96G03	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]	0.456338028169024	0.0764041844075847	0.9390975406632908	1.0	0.9808183522436472	2	Q96G03	1
+Anticodon-binding [IPR004154]	0.3468045112782058	0.0749125009296989	0.9402843302033764	1.0	0.98126897235328	5	P41250,P49590,P26639,Q9BW92	4
+NSD, Cys-His rich domain [IPR041306]	0.4532081377151891	0.0735085391472146	0.9414014492034222	1.0	0.98126897235328	2	O96028	1
+Peptidase C2, calpain, domain III [IPR022683]	0.448513302034439	0.0693651870184295	0.9446989388840504	1.0	0.9826997007056132	2	P17655	1
+Calpain subdomain III [IPR033883]	0.448513302034439	0.0693651870184295	0.9446989388840504	1.0	0.9826997007056132	2	P17655	1
+Peptidase C2, calpain, large subunit, domain III [IPR022682]	0.448513302034439	0.0693651870184295	0.9446989388840504	1.0	0.9826997007056132	2	P17655	1
+Peptidase C2, calpain, catalytic domain [IPR001300]	0.448513302034439	0.0693651870184295	0.9446989388840504	1.0	0.9826997007056132	2	P17655	1
+Nucleotidyl transferase domain [IPR005835]	0.4219092331768469	0.0501099656275078	0.960034758294259	1.0	0.9958436885218304	2	Q9NR50	1
+Dynamin, GTPase domain [IPR001401]	0.4292423293675741	0.0496323400144256	0.9604153747770476	1.0	0.9958436885218304	3	O00429,O60313	2
+Dehydrogenase, E1 component [IPR001017]	0.4283030682529731	0.0488561151840718	0.961033962079263	1.0	0.9960857017783462	3	Q96HY7,P08559	2
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.3102018828167083	0.0480143902239852	0.96170477409424	1.0	0.9963816289293688	7	Q92905,O15372	2
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.4261659598852575	0.0471215384427922	0.9624163612082772	1.0	0.996719547490831	3	Q8IWB9	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.4240523531079916	0.0454487750466341	0.9637496042617464	1.0	0.99770075124935	3	Q9BUJ2	1
+Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]	0.404694835680761	0.0410449021007963	0.967260099303191	1.0	0.9996981462355692	2	Q9Y678	1
+Coatomer subunit gamma, C-terminal [IPR032154]	0.404694835680761	0.0410449021007963	0.967260099303191	1.0	0.9996981462355692	2	Q9Y678	1
+Beta-adaptin appendage, C-terminal subdomain [IPR015151]	0.4170319348779064	0.0401911658738286	0.967940720552526	1.0	0.9996981462355692	3	Q10567,P63010	2
+Extended synaptotagmin, C-terminal C2 domain [IPR037752]	0.3962441314554075	0.0374295750373115	0.9701424917173012	1.0	0.9996981462355692	2	Q9BSJ8	1
+Extended synaptotagmin, C2B domain [IPR037749]	0.3962441314554075	0.0374295750373115	0.9701424917173012	1.0	0.9996981462355692	2	Q9BSJ8	1
+Synaptotagmin, SMP domain [IPR039010]	0.3962441314554075	0.0374295750373115	0.9701424917173012	1.0	0.9996981462355692	2	Q9BSJ8	1
+Extended synaptotagmin, C2A domain [IPR037733]	0.3962441314554075	0.0374295750373115	0.9701424917173012	1.0	0.9996981462355692	2	Q9BSJ8	1
+Serine-threonine protein phosphatase, N-terminal [IPR031675]	0.3812206572770043	0.0321777636485853	0.9743302890327608	1.0	1.0	2	P62136	1
+Peptidase C14,  p20 domain [IPR001309]	0.3784037558685544	0.0313440298715433	0.9749951768831218	1.0	1.0	2	Q9UDY8	1
+Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]	0.3690140845070512	0.028871274413205	0.9769672557653042	1.0	1.0	2	Q06124	1
+Protein-tyrosine phosphatase, catalytic [IPR003595]	0.3690140845070512	0.028871274413205	0.9769672557653042	1.0	1.0	2	Q06124	1
+NUDIX hydrolase domain [IPR000086]	0.3161027568922424	0.0270530067294582	0.9784174562247308	1.0	1.0	5	Q9UKK9,O43809,P36639,Q9BW91	4
+Adenylate kinase, active site lid domain [IPR007862]	0.3948027551659365	0.0263751880680895	0.9789580843171676	1.0	1.0	3	P27144,Q9UIJ7	2
+NAD-dependent epimerase/dehydratase [IPR001509]	0.3916718847839638	0.0247491234965952	0.980255072180186	1.0	1.0	3	Q9NRG7,Q13630	2
+Legume-like lectin [IPR005052]	0.3888541014401951	0.0233482378972064	0.981372493909014	1.0	1.0	3	Q12907,P49257	2
+CAP Gly-rich domain [IPR000938]	0.3860363180964301	0.0220051375354744	0.9824438573705494	1.0	1.0	3	Q99426,Q15813	2
+Zinc finger, TFIIB-type [IPR013137]	0.3101721439749711	0.0210403757839474	0.9832134475781906	1.0	1.0	2	P29083	1
+Pumilio homology domain [IPR033133]	0.3061032863849868	0.0208181258978461	0.9833907384966494	1.0	1.0	2	Q14671	1
+Ribosomal protein S10 domain [IPR027486]	0.3042253521126866	0.0207241078989814	0.9834657378257794	1.0	1.0	2	P60866	1
+Sec63 domain [IPR004179]	0.3672510958046325	0.0144204987433544	0.9884945054577507	1.0	1.0	3	Q8N3C0,Q9UGP8	2
+PurM-like, C-terminal domain [IPR010918]	0.3647463994990517	0.0135751834696921	0.9891689033696895	1.0	1.0	3	O15067,P49903	2
+Elongation Factor G, domain II [IPR041095]	0.3167023880716059	0.0109892331499038	0.9912320370095946	1.0	1.0	4	P13639,Q96RP9	2
+Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]	0.3556585983120159	0.0108014578570385	0.9913818511240796	1.0	1.0	3	P00390	1
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.3443957420162779	0.0079467112536303	0.9936595085155452	1.0	1.0	3	Q99797,Q9BYT8	2
+Zinc finger, UBR-type [IPR003126]	0.3309329993738202	0.0052658044742069	0.9957985153267817	1.0	1.0	3	Q5T4S7,Q8N806	2
+Ubiquitin-conjugating enzyme E2 [IPR000608]	0.2874783058021377	0.0034662464909927	0.9972343409790708	1.0	1.0	7	P60604	1
+Glutaredoxin [IPR002109]	0.2929464661851031	0.0008671045417809	0.9993081507602076	1.0	1.0	3	Q16881	1