msigdb_reactome/result.tsv

Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
Creb phosphorylation	0.8878935939196526	2.4729081997513696	0.0134018563672029	0.999999995533998	0.1446791312368497	2	P51812	1
Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects	0.8726927252985885	2.407082528640231	0.0160805355140363	0.9999999999072398	0.1643088887081328	2	Q00534	1
Maturation of sars cov 1 nucleoprotein	0.8721498371335505	2.4047230439239717	0.0161847263504517	0.9999999999202328	0.1643088887081328	2	P49840	1
Recruitment of mitotic centrosome proteins and complexes	0.5310936472767211	2.308896664450864	0.0209493161345382	0.9999999999999212	0.2000578625735248	35	O15078,Q96RT8,Q13561,Q7Z4H7,Q7Z460,Q96CS2,Q13409,P06493,P53350,O95684,Q15154,P41208,O75935	13
Mitochondrial fatty acid beta oxidation	0.6287311381359286	2.259890273948432	0.0238280617043169	0.9999999999999988	0.2176601790298182	18	P11310,P30084	2
Recruitment of numa to mitotic centrosomes	0.5051426524311766	2.2439064252452536	0.0248384226622619	0.9999999999999998	0.2226085049919706	39	O15078,Q96RT8,Q13561,Q7Z4H7,Q7Z460,Q96CS2,Q13409,P06493,P53350,O95684,Q15154,P41208,O75935	13
Surfactant metabolism	0.8279044516829532	2.2104542845962145	0.0270736499112156	1.0	0.2366868167084802	2	Q9P031	1
Anchoring of the basal body to the plasma membrane	0.5224123957780823	2.194726833657132	0.0281831986687317	1.0	0.2448845006276997	34	O15078,Q13561,Q7Z4H7,Q7Z460,Q96CS2,Q13409,P06493,P53350,O95684,Q15154,P41208,O75935	12
Runx1 regulates transcription of genes involved in differentiation of hscs	0.4898662701309887	2.159125965514152	0.0308403957239349	1.0	0.2623832393995861	41	Q03164,P28070,P28074,P49721,P28072	5
Aurka activation by tpx2	0.5115890398973018	2.157255982986897	0.0309857246175542	1.0	0.2623832393995861	35	O15078,Q13561,Q7Z4H7,Q7Z460,O75330,Q96CS2,Q13409,P06493,P53350,O95684,Q15154,P41208,O75935	13
Mitochondrial fatty acid beta oxidation of saturated fatty acids	0.8355787099732801	2.155563930928593	0.0311177315498456	1.0	0.2623832393995861	7	P11310	1
Myoclonic epilepsy of lafora	0.8143322475570032	2.1500926508653286	0.0315478868209242	1.0	0.2628990568410354	2	P46976	1
Rhobtb1 gtpase cycle	0.5859977153693795	2.0622173595424433	0.039187046700263	1.0	0.3068216568564553	20	Q96T58,Q8IYB3,P07910,Q8N684,P08670,Q7Z6E9,P78371,P38159,P62995,O75116,O43396	11
Organelle biogenesis and maintenance	0.3849806086335295	2.056248136483203	0.0397586045829254	1.0	0.3086234253879259	101	Q04837,P48735,Q96FJ2,Q86X55,Q9UPT5,Q15154,A6NIH7,O75935,Q7Z4H7,Q13561,Q14203,A0AVF1,Q13505,P53350,P54646,O95684,Q8IYI6,Q9NX63,Q9BVA1,Q7Z460,Q96CS2,Q13409,P06493,P78371,O43805,O43924,Q15648,O15078,Q8NCM8,P41208,Q8TAG9	31
Metabolism of lipids	0.33903244059298	2.042067812897024	0.0411448051338398	1.0	0.3134865088008516	215	P11310,Q8NAN2,O43772,Q709F0,P35790,Q15800,P09960,O43681,Q9NPH0,Q96G23,Q9NQZ5,O15254,Q8NCC3,P07686,Q15392,Q16850,O15121,Q15165,O76062,Q8IV08,Q9HCL2,P34913,P30084,P37268,O95772,O60244,Q8TBX8,P67870,P23786,Q15648,Q6UWP7,Q86SK9	32
Beta oxidation of octanoyl coa to hexanoyl coa	0.8932930823732399	2.0257385242750736	0.0427915866562225	1.0	0.319972540166277	5	P11310	1
Beta oxidation of decanoyl coa to octanoyl coa coa	0.8932930823732399	2.0257385242750736	0.0427915866562225	1.0	0.319972540166277	5	P11310	1
Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux	0.9156465021531788	2.0023853243155663	0.0452433056259864	1.0	0.3323284047269623	4	Q8NB78	1
Wnt mediated activation of dvl	0.9004241276281773	1.9914300573901476	0.0464336275121415	1.0	0.3393226625887265	3	O14641	1
Mitotic g2 g2 m phases	0.3829807927216812	1.9638972484664077	0.049542009020846	1.0	0.3494918953203248	97	P14635,P28074,O75330,Q15154,O75935,Q7Z4H7,Q13561,P30307,P20618,P30154,P53350,O95684,P28070,Q7Z460,Q96CS2,Q13409,P49721,P06493,O43805,O15078,Q96RT8,Q5TKA1,P28072,Q99436,P41208,Q99640	26
Interleukin 12 signaling	0.5365911050356118	1.9411728492856115	0.0522373151795372	1.0	0.361527719465357	26	P22626,P14174,P52907,Q13126,P11233,O00170,O14979,P52597	8
Rhobtb gtpase cycle	0.5139092918599187	1.9393265447077432	0.0524615886127819	1.0	0.361527719465357	30	Q16543,Q8IYB3,Q9NYL9,Q8N684,P08670,P78371,P38159,P62995,Q12792,O43396	10
Cilium assembly	0.4278895527983843	1.9304566897624784	0.0535502766103754	1.0	0.361527719465357	65	Q96FJ2,Q9UPT5,Q15154,A6NIH7,O75935,Q13561,Q7Z4H7,A0AVF1,P53350,O95684,Q8IYI6,Q9BVA1,Q7Z460,Q96CS2,Q13409,P06493,P78371,O43805,O43924,O15078,Q8NCM8,P41208,Q8TAG9	23
Camk iv mediated phosphorylation of creb	0.765472312703583	1.9299291515082464	0.0536156168259942	1.0	0.361527719465357	2	P52292	1
Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde	0.765472312703583	1.9299291515082464	0.0536156168259942	1.0	0.361527719465357	2	P52292	1
Nr1h2 and nr1h3 mediated signaling	0.8207639416774797	1.9287666622703337	0.0537598362629543	1.0	0.361527719465357	6	Q8NB78	1
Noncanonical activation of notch3	0.8842435523324559	1.9285406787255692	0.0537879095461644	1.0	0.361527719465357	3	P67809	1
Gene and protein expression by jak stat signaling after interleukin 12 stimulation	0.5446720379051663	1.9265247847920703	0.0540388801727165	1.0	0.361527719465357	24	P22626,P14174,P52907,Q13126,P11233,O00170,O14979,P52597	8
Metabolism of steroids	0.4350302330854337	1.9199968096944788	0.0548583023863611	1.0	0.3650767487509918	53	Q15800,Q96SU4,Q86X55,Q9Y6B6,Q15392,P51659,O95486,O14975,Q16850,P61956,P38435,O76062,Q9HCL2,Q9H2C2,P37268,O95772,O75845,O00767,Q15648,Q9UBM7,P22307,P48449	22
Interleukin 12 family signaling	0.5168273913957705	1.9176047771168991	0.0551611439506745	1.0	0.3650767487509918	29	P22626,P14174,P52907,Q13126,P11233,O00170,O14979,P52597	8
Translation of sars cov 2 structural proteins	0.5716392567899237	1.916213314660904	0.0553379492843608	1.0	0.3650767487509918	18	Q9H0U3	1
Transcriptional activation of mitochondrial biogenesis	0.6217033325131232	1.914153137720095	0.0556005915437909	1.0	0.3651190919350326	14	P48735,Q15648	2
Met activates pi3k akt signaling	0.7595005428881649	1.9027273833135003	0.0570761268906452	1.0	0.3713857571651573	2	Q9NWH9	1
Cyclin a b1 b2 associated events during g2 m transition	0.6537015071474346	1.8598442672533824	0.0629075623443633	1.0	0.3966516652244148	11	P14635,P30307,P30154,P06493,Q99640	5
Gamma carboxylation hypusine formation and arylsulfatase activation	0.6368833429443187	1.842848070235344	0.065351196063073	1.0	0.4084449753942065	12	O43681,O60725,Q9HA64,P38435	4
G2 m dna replication checkpoint	0.8612544121639996	1.8386064989989743	0.0659730846920938	1.0	0.4087462855923205	3	P06493,Q99640	2
Erythropoietin activates phospholipase c gamma plcg	0.7442996742671009	1.8332179835719105	0.0667701605324118	1.0	0.4101184429253742	2	P19174	1
Metabolism of porphyrins	0.6706369803225489	1.820413936144219	0.0686959917262344	1.0	0.4183409752559147	10	P22830,P30519,P30043,Q7KZN9	4
Regulation of plk1 activity at g2 m transition	0.4518167466864245	1.7981299052772943	0.0721564241560188	1.0	0.4302213574155936	39	P14635,O15078,Q13561,Q7Z4H7,Q7Z460,Q96CS2,Q13409,P06493,P53350,O95684,Q15154,P41208,O75935	13
Phosphorylation of emi1	0.8468639695900068	1.7819813844523735	0.074752267489313	1.0	0.4401734759184758	3	P14635,P06493	2
Irf3 mediated activation of type 1 ifn	0.7299131378935938	1.7670942190248924	0.0772124505151388	1.0	0.4490928244247869	2	Q9UHD2	1
Metabolism of cofactors	0.7437421656062757	1.7629613459402178	0.0779070092448166	1.0	0.4512906023327793	7	O75874	1
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex	0.632572830546248	1.752094734320822	0.0797575195709661	1.0	0.453777305180414	11	P14635,P31946,Q9Y3B8,P30307,P06493,O14757,Q04917	7
Irak1 recruits ikk complex	0.837360847135488	1.744456482659775	0.0810795233258117	1.0	0.453777305180414	3	P61088,O15111	2
Ticam1 rip1 mediated ikk complex recruitment	0.837360847135488	1.744456482659775	0.0810795233258117	1.0	0.453777305180414	3	P61088,O15111	2
Small interfering rna sirna biogenesis	0.8482025000529687	1.7443142652657408	0.0811043055173832	1.0	0.453777305180414	4	Q15631	1
Biosynthesis of specialized proresolving mediators spms	0.8368232385908208	1.742330631940057	0.081450606350391	1.0	0.453777305180414	3	P09960	1
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function	0.6297438083662892	1.7375916140097307	0.0822827985267689	1.0	0.453777305180414	11	Q03164	1
Hsf1 dependent transactivation	0.558594334841169	1.721464541194898	0.0851665612463863	1.0	0.457971131230568	16	Q13555,Q15185,P25685,O75190,Q02790,P08238,P54652,P42345,Q00613,P07900	10
Rhobtb2 gtpase cycle	0.5290614217524701	1.702634536424679	0.0886364827095271	1.0	0.464929840496482	20	Q16543,Q9NYL9,P78371,P38159,P62995,Q12792,O43396	7
Regulation of cholesterol biosynthesis by srebp srebf	0.4872122581675234	1.702048772763695	0.0887462257370432	1.0	0.464929840496482	29	Q9Y6B6,O75845,O00767,Q15648,O95486,P37268,Q16850,Q9UBM7,Q86X55,O76062,Q03426,P48449,Q9HCL2	13
Rnd1 gtpase cycle	0.5405819275528538	1.7013899642843695	0.0888697845358075	1.0	0.464929840496482	17	Q99569,Q13017,P38159,O00459,O43396,Q03001	6
Regulation of lipid metabolism by pparalpha	0.5110913687407231	1.7003198991211996	0.0890707694424839	1.0	0.464929840496482	24	P11310,Q15648,P37268	3
Metabolism of folate and pterines	0.6689236084756909	1.695529221069132	0.0899750718067577	1.0	0.467820192849031	9	P00374,P41440	2
Cholesterol biosynthesis	0.5277027801958795	1.6939168222986958	0.0902810898480586	1.0	0.467820192849031	20	O75845,Q15392,Q9H2C2,Q15800,P37268,Q16850,Q9UBM7,Q03426,O76062,P48449	10
Bmal1 clock npas2 activates circadian gene expression	0.8213412978549954	1.6809789933297343	0.0927669949263503	1.0	0.4784291782655435	3	P43490,Q15648	2
Condensation of prometaphase chromosomes	0.6656209257805625	1.6797810808748097	0.0929999174593372	1.0	0.4784291782655435	9	P67870,P14635,P06493	3
Fatty acid metabolism	0.4034245787503702	1.6758105133897878	0.093775314166014	1.0	0.4785346783290211	65	P11310,Q9H7Z7,Q86SK9,O43772,Q709F0,P51659,P34913,Q9Y305,P30084,P09960,Q15165,P54646,Q5T8D3,O15254,P23786,Q9UKU0	16
Interleukin 1 family signaling	0.4092439430811788	1.674522956285349	0.0940278666190357	1.0	0.4785346783290211	55	O43242,P28074,P43378,P20618,P09429,P62191,P60900,Q02750,P61088,P28070,Q9H0E2,P49721,O14920,Q13616,Q9UHD2,Q99436,P28072,P25787,O15111	19
Rnd3 gtpase cycle	0.5258708775902063	1.6562822496202754	0.0976646734268238	1.0	0.4900428156099435	19	Q99569,Q9NYL9,Q03001,P38159,O00459,O43396,O75976,Q13017	8
Response of eif2ak1 hri to heme deficiency	0.8140103176758071	1.651843030909177	0.0985665540258835	1.0	0.4917456943598375	3	P05198,P08243	2
Transport of bile salts and organic acids metal ions and amine compounds	0.749522955352619	1.6334664706040654	0.1023709269866524	1.0	0.4995841471095194	6	P53985,Q9H2J7	2
Role of phospholipids in phagocytosis	0.7921588897410992	1.6279299343613485	0.1035397432909568	1.0	0.5018507965633112	5	Q8IV08,O43865,O00459	3
Synthesis of pc	0.7466560674521747	1.6214434196168923	0.104922575179577	1.0	0.5034163960636272	6	P35790,Q9NQZ5	2
Glycerophospholipid biosynthesis	0.4425472676466568	1.6039669676911374	0.108721333930057	1.0	0.513488391772591	35	Q8NAN2,Q8NCC3,P35790,Q9NPH0,Q6UWP7,Q9NQZ5,Q8IV08,Q9HCL2	8
Mtorc1 mediated signalling	0.5915175197198796	1.6035036461697771	0.1088235047826824	1.0	0.513488391772591	12	P62942	1
Nuclear signaling by erbb4	0.741279742975137	1.598871308520586	0.1098492003751974	1.0	0.5151887670111518	6	P78536	1
Polo like kinase mediated events	0.7060608950141801	1.597944245036372	0.1100553860381463	1.0	0.5151887670111518	7	P14635,Q5TKA1,P30307,P53350,Q99640	5
Hyaluronan metabolism	0.783609710764593	1.593752211681293	0.1109915448929288	1.0	0.5151887670111518	5	P07686,P08236	2
Hyaluronan uptake and degradation	0.783609710764593	1.593752211681293	0.1109915448929288	1.0	0.5151887670111518	5	P07686,P08236	2
Activation of gene expression by srebf srebp	0.5061577806088399	1.5813074889504442	0.1138077481091595	1.0	0.5231485195340396	21	O75845,O00767,Q15648,P37268,Q16850,Q9UBM7,Q86X55,O76062,Q03426,P48449,Q9HCL2	11
Cyclin d associated events in g1	0.6162126366556082	1.5509544873509469	0.1209125912762782	1.0	0.5504806471843341	10	P07948,P30154,P42771,P11802,Q00534,Q13616	6
Signaling by notch4	0.4097261211710886	1.5407221640946558	0.1233844201252614	1.0	0.5581676148523731	45	P28070,P28072,P20618,P28074,P49721,Q9Y6A5,Q99436,Q13616,P62191,P49768,Q13573,P25787,O43242,P60900	14
Ikk complex recruitment mediated by rip1	0.7940066887531898	1.5333302918922302	0.1251944945841874	1.0	0.5590751841510693	4	P61088,O15111	2
Clec7a dectin 1 signaling	0.3951390221747182	1.528899092506616	0.1262894612667815	1.0	0.5590751841510693	52	O15111,P49427,P61088,P28070,O43865,P20618,P28074,O14920,P49721,Q99436,Q8TBC4,P62191,P28072,P25787,Q14790,O43242,P60900	17
Class a 1 rhodopsin like receptors	0.6895087738140402	1.524879196005464	0.127289231763815	1.0	0.5590751841510693	7	P42892	1
Peptide ligand binding receptors	0.6895087738140402	1.524879196005464	0.127289231763815	1.0	0.5590751841510693	7	P42892	1
Downstream signaling events of b cell receptor bcr	0.4054321665257605	1.523338864630333	0.1276739485567777	1.0	0.5590751841510693	46	P28070,P28074,P49721,P62942,P28072	5
Rab regulation of trafficking	0.4179933459690134	1.5224326510081267	0.1279007087952621	1.0	0.5590751841510693	40	P31150,P50395	2
Wnt ligand biogenesis and trafficking	0.7215210738136381	1.515655707332411	0.129606432967974	1.0	0.5630767285956189	6	Q5T9L3	1
Interleukin 37 signaling	0.7613970145324669	1.504644744533471	0.132415436086857	1.0	0.5705454536757761	5	P43378	1
Regulation of runx3 expression and activity	0.4204205476780666	1.502611040869255	0.1329393745913751	1.0	0.5705454536757761	37	P28070,P20618,P28074,P49721,Q99436,P42771,P62191,P28072,P25787,O43242	10
Ptk6 regulates proteins involved in rna processing	0.7762693456421232	1.5011086421646465	0.1333274639116024	1.0	0.5705454536757761	3	P23246,O75525	2
Mitotic g1 phase and g1 s transition	0.3678369822268749	1.4947424117359387	0.1349816809868249	1.0	0.575894896425825	81	P33993,P14635,P33991,Q9NR33,P49642,P28074,Q14566,P31350,P00374,P20618,P07948,P30154,P04818,P42771,P62191,Q00534,P60900,O00231,P63151,P28070,P49721,P06493,P11802,Q13616,Q5TKA1,O00311,P20248,Q99436,P28072,P25787,O43242	31
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand	0.4481015156433678	1.4872072756384815	0.136960075061836	1.0	0.5808574611997511	31	Q15185,P31948,P25685,Q13561,P31689,Q96FJ2,P52907,Q9BVA1,Q14203,P61163,Q9UJW0,Q13409,P54652,Q9Y6G9,O60884,O75935	16
Tcr signaling	0.3900933984316884	1.4787658468820597	0.1392029067539497	1.0	0.5886176324165531	51	P25787,O15111,P49427,P61088,P28070,P20618,P28074,O14920,P49721,P19174,Q99436,P62191,P28072,O00459,O43242,P60900	16
Slc mediated transmembrane transport	0.4694604078177737	1.4717629411614277	0.141084904231584	1.0	0.5905091646382883	26	Q70HW3,P53985,Q9H2J7,O00400	4
Interleukin 1 signaling	0.389294706550393	1.4709382872314063	0.1413078071169518	1.0	0.5905091646382883	50	O15111,P61088,P28070,Q9H0E2,P20618,P28074,O14920,P49721,P09429,P60900,Q13616,Q99436,P62191,P28072,P25787,O43242,Q02750	17
Antigen processing ubiquitination proteasome degradation	0.3419327941281608	1.4641240675905218	0.1431600523699774	1.0	0.5945050563452465	100	P28074,Q9BSL1,Q8TBC4,Q9UIQ6,Q8NEZ5,Q9UJX2,P55786,Q15345,Q16763,Q8TDB6,P49427,P20618,P62191,P61086,P19474,P60900,Q93034,P28070,P61088,Q9H1A4,P49721,Q9UII4,P60604,Q15386,Q99436,P28072,P25787,O43164,O43242	29
Auf1 hnrnp d0 binds and destabilizes mrna	0.4046364862760725	1.4368374377153703	0.1507641899601899	1.0	0.6085996302867296	42	P28070,P20618,P28074,Q14103,P11940,P49721,Q04637,Q99436,P62191,P28072,P25787,O43242	12
Mastl facilitates mitotic progression	0.7423845559760873	1.4280831678610784	0.1532679216918406	1.0	0.6135022146372836	5	P30154,P06493	2
Cell surface interactions at the vascular wall	0.4860851203592041	1.4243748340878406	0.1543379951689365	1.0	0.6143341986473033	20	P14174	1
Rsk activation	0.7640268067152284	1.4156375854401104	0.1568816409596192	1.0	0.6227196054803826	4	P51812	1
Attenuation phase	0.543990102267288	1.4111050805839958	0.1582136321707596	1.0	0.6229231398671794	13	Q15185,P25685,O75190,Q02790,P08238,P54652,Q00613,P07900	8
Rab gefs exchange gtp for gdp on rabs	0.4317610129444637	1.400893582265151	0.1612458981956313	1.0	0.6295216573391084	32	P50395	1
Sars cov 2 infection	0.4587876810271546	1.395885209097928	0.1627490653828527	1.0	0.6318451848187001	26	Q9H0U3	1
Tp53 regulates transcription of genes involved in g2 cell cycle arrest	0.5834300967278454	1.3863641767760837	0.1656357293657904	1.0	0.6379213901250037	10	P14635,Q9Y3B8,Q07812,P30307,P06493	5
Estrogen dependent gene expression	0.4337678164149909	1.376836168290685	0.1685629058153344	1.0	0.6474451234146942	31	P35269,Q9HCL2,Q15648,P50750	4
Class i mhc mediated antigen processing presentation	0.322453928978242	1.3698015459328017	0.1707488593665247	1.0	0.6502270856886433	129	Q6P179,O15111,P28074,Q9BSL1,Q8TBC4,Q9UIQ6,Q8NEZ5,Q9UJX2,P55786,Q15345,Q16763,Q9Y6B6,Q8TDB6,P49427,O95486,P10321,P20618,P09429,P62191,P61086,P60059,P19474,P60900,Q93034,P28070,P61088,Q9H1A4,P49721,Q9UII4,P60604,O14920,Q15386,Q99436,P28072,P25787,O43164,O43242	37
Beta oxidation of pristanoyl coa	0.7523169861384751	1.369549654940649	0.1708275244544617	1.0	0.6502270856886433	4	P51659,O15254	2
Glycogen metabolism	0.5799351757809892	1.368747884152384	0.1710780966941787	1.0	0.6502270856886433	10	Q96G03,P46976,Q93100,P13807	4
Amyloid fiber formation	0.6537463203546969	1.3661182059901436	0.1719018648100521	1.0	0.6502270856886433	7	Q9UJY4	1
Oncogene induced senescence	0.6536646598677789	1.365754643897478	0.1720159867579325	1.0	0.6502270856886433	7	Q9HCE1,Q00534,P42771	3
Adaptive immune system	0.303167877855221	1.3639070461889535	0.1725968229005448	1.0	0.6502270856886433	213	Q6P179,O15111,Q96FJ2,P52907,Q9BXS5,Q13362,P28074,P62942,Q9BSL1,Q8TBC4,Q9Y6G9,Q9UIQ6,Q8NEZ5,P55786,Q9UJX2,O75935,Q15345,Q16763,Q9Y6B6,Q8TDB6,P31946,Q9H0H5,P49427,Q13561,O95486,P10321,P20618,Q14203,Q13586,P30154,P09429,P62191,Q9H0B6,P61086,P60059,P19474,P60900,Q93034,P28070,P61088,Q9BVA1,Q9H1A4,Q13409,P49721,Q9UII4,P60604,O14920,Q13616,P52732,O43865,Q9NS87,Q9NSK0,O00459,Q9UJW0,P19174,Q07866,P56377,Q15386,Q99436,P62993,P28072,P25787,O43164,O43242	64
Scf skp2 mediated degradation of p27 p21	0.3981124686851655	1.362822898984239	0.1729383324478743	1.0	0.6502270856886433	41	O00231,P28070,P20618,P28074,P49721,P20248,Q99436,P11802,Q13616,P62191,P28072,P25787,O43242,P60900	14
Map3k8 tpl2 dependent mapk1 3 activation	0.7256280099405854	1.3604444328488718	0.173689325805145	1.0	0.6502270856886433	5	O14920,O15111,Q13616	3
Release of apoptotic factors from the mitochondria	0.7411217319176563	1.3599359631016728	0.1738501892262267	1.0	0.6502270856886433	3	Q07812	1
Programmed cell death	0.3262717841967226	1.3571188126167608	0.1747434618123526	1.0	0.6518571546664987	107	Q9Y3B8,Q96FJ2,P28074,Q9UQN3,Q9NR28,Q14790,Q16625,P31946,P41440,Q07812,P20618,P35611,P09429,P42771,P62191,Q9UKG1,Q16543,P28070,P08670,P49721,Q9P289,P26583,Q9UDY2,Q99436,Q07021,P28072,P25787,O43242	28
Signaling by interleukins	0.3217320463451105	1.3549977112259937	0.1754182862444606	1.0	0.652665947515291	118	P14174,P52907,P28074,P43378,O14979,Q15418,P20618,P30154,P09429,P11233,Q13126,P28070,P61088,P22626,P08670,P49721,P51812,O00170,P52597,Q9UHD2,Q99436,P28072,O00459,O15111	24
Fceri mediated nf kb activation	0.3839998543837064	1.3452576215382486	0.1785420539399602	1.0	0.659084639062395	47	O15111,P49427,P61088,P28070,P07948,P28074,P20618,P49721,O14920,Q99436,Q13616,P62191,P28072,P25787,O43242,P60900	16
Signaling by notch	0.3712407115112019	1.343460754191951	0.1791228257973842	1.0	0.659084639062395	66	Q04727,P28070,P28074,P49721,Q9HCE1,Q99436,P78536,P28072,P67809	9
Regulation of runx1 expression and activity	0.7361214185053708	1.339818825821521	0.1803042536362031	1.0	0.659084639062395	3	Q9HCE1	1
Glycogen synthesis	0.7202410275639942	1.3386775550401218	0.1806756661989439	1.0	0.659084639062395	5	Q96G03,P46976	2
Myd88 independent tlr4 cascade	0.4505876160889553	1.3374488932635058	0.1810761538654315	1.0	0.659084639062395	26	Q9UHD2,O15111,P61088,P30154,P09429,P51812,Q14790,Q15418	8
Mrna splicing	0.3158698541915114	1.3367339139322827	0.1813095076260948	1.0	0.659084639062395	148	Q86V81,P35269,Q13151,O75940,Q92620,O43390,Q9BZI7,Q13242,O43395,Q9H2H8,P67809,P55795,Q8N684,P31943,P13984,Q07955,P52298,Q15287,Q8IYB3,P61978,P22626,Q14103,Q86U42,P38159,O43290,Q7L014,Q13573,P52597,O75494,Q6UN15,P42285,P62995,Q92733,Q9BUJ2,Q99459,Q15459,Q9Y2W2,Q16629,Q15427,P51991,P35637	41
Nectin necl trans heterodimerization	0.6365363735070575	1.3320414125288498	0.1828465805886674	1.0	0.660918922162088	2	Q92692	1
Transcriptional regulation by runx1	0.3658938923358097	1.3303790590026912	0.1833934106359276	1.0	0.660918922162088	71	Q03164,P28070,P28072,P28074,P49721,Q9HCE1,Q99436,Q96GM5,Q00534,P67870,Q9HCL2,Q16625	12
Sphingolipid de novo biosynthesis	0.5508989281108914	1.327581937402749	0.1843162548907082	1.0	0.660918922162088	11	Q96G23	1
Heme degradation	0.7414498052674021	1.3267436529728844	0.1845934954529902	1.0	0.660918922162088	4	P30043	1
Lysosome vesicle biogenesis	0.4928548231907654	1.3253290302269425	0.1850620444527713	1.0	0.6609358730456117	16	P78537,P56377,O14964,P20645	4
Negative regulation of notch4 signaling	0.3949473545942494	1.320615201558858	0.1866297015198261	1.0	0.6620869789799277	40	P28070,P20618,P28074,P49721,Q9Y6A5,Q99436,Q13616,P62191,P28072,P25787,O43242,P60900	12
Cytoprotection by hmox1	0.3655746778211498	1.3167937924951842	0.187907754155653	1.0	0.6625513488888931	70	P15954,Q15648,P28070,Q9BX63,Q8N8Q8,P30043,P28072,P20618,P28074,P20674,P49721,P00403,Q99436,P67870,P30519,O43242	16
Cyclin a cdk2 associated events at s phase entry	0.3872442538258622	1.3148716434895606	0.1885530442678002	1.0	0.6625513488888931	44	O00231,Q5TKA1,P28070,P20618,P28074,P49721,P20248,Q99436,P11802,Q13616,P62191,P28072,P25787,O43242,P60900	15
N glycan trimming and elongation in the cis golgi	0.6316503800217155	1.3091301061281984	0.1904902827532235	1.0	0.6658124098708622	2	P33908	1
Signaling by the b cell receptor bcr	0.3727516712607449	1.3087099919782117	0.1906326057735521	1.0	0.6658124098708622	51	O15111,P28070,O43865,P07948,P28074,P20618,Q13586,P62942,P49721,O14920,Q13616,Q99436,P62993,P62191,P28072,P25787,O43242,P60900	18
Heme signaling	0.6389303273027012	1.3001084765160864	0.1935637928569833	1.0	0.6709236081687775	7	Q9BX63,Q15648	2
Nod1 2 signaling pathway	0.5866789957230278	1.298896890700259	0.1939793168880956	1.0	0.6709236081687775	9	P61088,Q14790,O15111	3
Cd163 mediating an anti inflammatory response	0.7212007493004238	1.2797791722211382	0.2006228108804246	1.0	0.687699315464602	3	P78536	1
Mitotic prometaphase	0.3258569854391752	1.2733137047416372	0.2029067454817845	1.0	0.6900766403616777	102	P14635,Q96FJ2,Q13362,Q9Y6G9,O43683,Q15154,O75935,Q8NBT2,Q7Z4H7,Q13561,P30154,P53350,O95684,Q9BVA1,Q9NTJ3,Q7Z460,Q96CS2,Q13409,P06493,Q71F23,P67870,O43805,O15078,Q96RT8,Q9Y266,P41208,O14777	27
Regulation of innate immune responses to cytosolic dna	0.6987617714876974	1.2518410013086338	0.2106278065217077	1.0	0.6992612058818348	5	P19474	1
Cooperation of prefoldin and tric cct in actin and tubulin folding	0.464120964723112	1.241007607352413	0.214602938611744	1.0	0.7078916377817946	18	Q9BVA1,P78371,Q9UHV9,Q99471,P61758	5
Heme biosynthesis	0.6559615108559236	1.2375923867089214	0.2158672388117044	1.0	0.710417587313346	6	P22830,Q7KZN9	2
Ripk1 mediated regulated necrosis	0.5218860404284809	1.2292207949093126	0.2189890342773246	1.0	0.7173778709084773	12	P41440,Q14790	2
Gpcr ligand binding	0.551638907026653	1.225855450638185	0.2202530759099263	1.0	0.7195258068511516	10	P42892	1
Signaling by notch3	0.5512051574377266	1.2236633253920397	0.2210792601110864	1.0	0.7195258068511516	10	P49768,P67809	2
Egr2 and sox10 mediated initiation of schwann cell myelination	0.5688051207379743	1.2119739015918238	0.2255223710558478	1.0	0.7216913763318685	9	Q16850,Q9NR77	2
Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol	0.7120277702708887	1.2108258987390323	0.2259621371036009	1.0	0.7216913763318685	4	P51659,P22307	2
Synthesis of pa	0.5078900664858148	1.210679358594536	0.2260183163326463	1.0	0.7216913763318685	13	Q9HCL2,Q9NPH0,Q6UWP7	3
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10	0.686639258241427	1.202842095296151	0.2290374314874723	1.0	0.7252851997103291	5	Q14790,O15111	2
Sting mediated induction of host immune responses	0.6149334106944934	1.1931152723154668	0.2328242310672545	1.0	0.7309015473032762	7	Q9UHD2,P19474	2
Tak1 activates nfkb by phosphorylation and activation of ikks complex	0.5839203546693643	1.1898336160913006	0.2341117942178945	1.0	0.7309015473032762	8	P61088,P09429,O15111	3
Mtor signalling	0.4585694894990768	1.188899642812116	0.234479160723132	1.0	0.7309015473032762	17	P31946,Q15382,Q04637,P31751,P62942,P23588,P42345,Q9Y376,P54646,P54619	10
Peroxisomal protein import	0.4297185661471551	1.188450466434505	0.2346559838751361	1.0	0.7309015473032762	26	O75874,Q15067,Q2T9J0,P51659,P34913,P22307,Q86WA8,O00116,O15254,P50542	10
Suppression of apoptosis	0.642941497536326	1.1822650364252565	0.2371005540787307	1.0	0.7344962816569377	6	P49840	1
Regulated necrosis	0.4480030744019831	1.1749497275176397	0.2400148291433084	1.0	0.7403054795004643	20	Q16543,P41440,Q07812,P09429,Q14790	5
Degradation of dvl	0.378706911099377	1.1664630887425802	0.2434272638620132	1.0	0.7443859463591606	39	P28070,P28074,P49721,Q99436,P28072	5
Fgfr1 mutant receptor activation	0.5177674091593591	1.153406042486376	0.2487437624899466	1.0	0.7488856718334466	11	O94905,O15164,O95429,Q92614,O95684,P62993,P42224	7
Transcriptional regulation by runx2	0.356907329275842	1.152261182808363	0.249213762799169	1.0	0.7488856718334466	52	P14635,Q96PK6,P28070,Q07812,P20618,P28074,P49721,Q99436,P06493,P11802,P49841,P62191,P28072,P25787,O43242,P60900	16
Fgfr2 alternative splicing	0.4497653623243857	1.1493801461111302	0.2503992630669032	1.0	0.7488856718334466	18	P35269,P31943,Q01085,P13984,P52597	5
Regulation of beta cell development	0.6884244295430504	1.1480615324779693	0.2509431628855161	1.0	0.7488856718334466	3	Q13573	1
Signaling by ntrk3 trkc	0.6314787942055231	1.1336090277885704	0.2569585844804267	1.0	0.7581076250198926	6	P19174,Q07812,Q8WX92,P62993	4
Phospholipid metabolism	0.3543289415848822	1.1323022767373905	0.2575073732620483	1.0	0.7581570390463199	59	Q8NAN2,Q8NCC3,P35790,Q8TBX8,Q9NPH0,Q6UWP7,Q9NQZ5,Q8IV08,Q9HCL2	9
Rnd2 gtpase cycle	0.4437960321688951	1.1284353112659178	0.2591361220393129	1.0	0.759812703510331	19	Q99569,Q03001,Q9Y266,P38159,O00459,O43396,Q13017	7
Degradation of axin	0.3763890717025967	1.1269164988343878	0.2597777869448769	1.0	0.7601300747360363	37	P28074,P28070,P49721,P28072	4
Interconversion of nucleotide di and triphosphates	0.4403422906933279	1.124710374381631	0.2607117840776292	1.0	0.7612997793250442	20	P17812,P27144,Q9H773	3
Mitochondrial biogenesis	0.3787245320372688	1.1111671195073156	0.2664964213858267	1.0	0.7721808308411997	36	P48735,Q15648	2
Protein localization	0.3251615774589203	1.1097613822497083	0.2671018643867211	1.0	0.7721808308411997	88	O75874,Q9Y3D6,Q99595,Q9Y5J7,Q9Y584,Q9NX63,P51659,O00116,P34913,O43681,Q15388,Q8N4Q1,Q9NR77,O60830,Q5T8D3,O15254,Q86WA8,P50542	18
Rac3 gtpase cycle	0.3742493743722362	1.1086769695239749	0.267569560578099	1.0	0.7721808308411997	37	Q9UQB8,Q9H0H5,Q86Y07,Q13017	4
Notch3 activation and transmission of signal to the nucleus	0.6215797921098023	1.0916606169607816	0.274982301720917	1.0	0.7845168621122086	6	P67809	1
Pkmts methylate histone lysines	0.4380898661313438	1.091557768452926	0.2750275271916838	1.0	0.7845168621122086	19	Q9H7B4,Q03164	2
Degradation of beta catenin by the destruction complex	0.3507085078780375	1.0913329824163116	0.2751263898053282	1.0	0.7845168621122086	52	P48729,Q04727,P28070,Q13362,P28074,P20618,P49721,P30154,Q99436,P49841,P62191,P28072,P25787,O43242,P60900	15
Regulated proteolysis of p75ntr	0.6795299744469716	1.083158816753634	0.2787379359775874	1.0	0.7903548519326906	4	P78536	1
Antigen processing cross presentation	0.3499375857751129	1.083023016870201	0.2787982067954391	1.0	0.7903548519326906	56	P25787,O15111,P28070,P10321,P20618,P28074,O14920,P49721,P09429,Q99436,P62191,Q9UIQ6,P28072,P60059,O43242	15
Hedgehog ligand biogenesis	0.3633249606704348	1.0814901332410312	0.2794791473306079	1.0	0.7903548519326906	43	P28070,P28074,P49721,P78536,P28072	5
Disassembly of the destruction complex and recruitment of axin to the membrane	0.541916187459159	1.0813604385870372	0.2795368123762509	1.0	0.7903548519326906	9	P49841,P30154,O14641,Q13362	4
Asymmetric localization of pcp proteins	0.3686627942030523	1.0793169469757753	0.2804464606648775	1.0	0.7903548519326906	39	P28070,P28074,P49721,Q99436,P28072	5
Negative regulators of ddx58 ifih1 signaling	0.5212486273404455	1.072442689714442	0.2835212422476414	1.0	0.7903548519326906	10	Q9UII4	1
Aggrephagy	0.4491210213350805	1.0589798331827456	0.2896089642206916	1.0	0.7903548519326906	16	P61088,P08670,Q96FJ2,Q13409,Q9Y6G9	5
Glycogen breakdown glycogenolysis	0.5845013094404108	1.0577496649398912	0.2901695862341999	1.0	0.7903548519326906	7	Q96G03,P46976,Q93100	3
The role of gtse1 in g2 m progression after g2 checkpoint	0.3468437519035836	1.0568736308038338	0.2905692644444788	1.0	0.7903548519326906	50	P14635,P28070,Q9BVA1,P20618,P28074,P49721,Q99436,P06493,P53350,P62191,P28072,P25787,O43242	13
Copi independent golgi to er retrograde traffic	0.4042360333092713	1.056655860413912	0.290668676564128	1.0	0.7903548519326906	28	Q15042,Q8TD16,Q13561,Q96FJ2,P68402,P52907,Q14203,P61163,Q9BVA1,Q13409,Q9UJW0,Q9Y6G9,Q10472,O75935	14
Toll like receptor cascades	0.3879331361199656	1.0566175710777936	0.2906861579998139	1.0	0.7903548519326906	32	Q9UHD2,O15111,P61088,P30154,P09429,P51812,Q14790,Q15418	8
Apoptosis	0.3162583002070107	1.0551739322242548	0.2913457839451732	1.0	0.7903548519326906	94	Q9Y3B8,Q96FJ2,P28074,Q9NR28,Q14790,Q16625,P31946,Q07812,P20618,P35611,P09429,P42771,P62191,Q9UKG1,P28070,P08670,P49721,Q9P289,P26583,Q9UDY2,Q99436,Q07021,P28072,P25787,O43242	25
Dectin 1 mediated noncanonical nf kb signaling	0.3595674040891171	1.047711378847451	0.2947716033817418	1.0	0.7903548519326906	43	O15111,P28070,P20618,P28074,P49721,Q99436,Q8TBC4,P62191,P28072,P25787,O43242,P60900	12
Hedgehog off state	0.3464172255953875	1.047601436191511	0.294822275488342	1.0	0.7903548519326906	54	P48729,P28070,Q8NCM8,Q9BVA1,P10644,P20618,P28074,P49721,Q99436,Q9Y496,Q13616,P49841,P62191,P28072,P25787,O43242,P60900	17
Ddx58 ifih1 mediated induction of interferon alpha beta	0.4240839369305101	1.0371676155673313	0.2996577477660795	1.0	0.7903548519326906	21	Q9UHD2,Q9UII4,P09429,Q14790,O15111	5
Tnfr2 non canonical nf kb pathway	0.3583039879616285	1.0363690383506703	0.3000300090681373	1.0	0.7903548519326906	43	O15111,P28070,P20618,P28074,P49721,Q99436,Q8TBC4,P62191,P28072,P25787,O43242,P60900	12
Signaling by fgfr1 in disease	0.4764823919585636	1.036310034571083	0.3000575262425162	1.0	0.7903548519326906	13	O94905,O15164,O95429,Q92614,P19174,O95684,P62993,P42224	8
Interleukin 15 signaling	0.6595702192351764	1.0327559743688564	0.3017181114660552	1.0	0.7909014366589293	3	P62993	1
Hiv transcription initiation	0.4330395682003688	1.028284846383637	0.3038158571060634	1.0	0.7909014366589293	17	P35269,Q92804,Q00403,P29083	4
Aryl hydrocarbon receptor signalling	0.6581591094216691	1.0271431569826184	0.3043530595375765	1.0	0.7909014366589293	3	Q15185,O00170	2
Apoptotic factor mediated response	0.5487645757053154	1.0255411977589115	0.3051078968112615	1.0	0.7909014366589293	8	Q9NR28,Q07812,P42771	3
Metabolism of polyamines	0.362100361411221	1.022567604505154	0.3065123331337678	1.0	0.7909014366589293	39	P28074,P28070,P49721,P28072	4
Kinesins	0.4158183623897326	1.021695040226778	0.3069252592788687	1.0	0.7909014366589293	23	P52732,Q9H0H5,Q9NS87,Q9NSK0,Q9BVA1,Q9BW19,Q07866,Q9Y496,Q9H0B6	9
Cross presentation of soluble exogenous antigens endosomes	0.362773642846428	1.019212996532542	0.3081018578949235	1.0	0.7925002662459676	38	P28074,P28070,P49721,P28072	4
Rhobtb3 atpase cycle	0.6398555448938399	1.0145387585084265	0.3103257448891769	1.0	0.7953492562357504	5	O14964,Q15345	2
Regulation of tp53 expression and degradation	0.4811493831240543	1.0094848443271796	0.3127421664656653	1.0	0.7954049195613575	12	Q9UER7,P30154,P42771,Q13362	4
Transcription of the hiv genome	0.3817992222627842	1.00865867352261	0.3131383578062607	1.0	0.7954049195613575	32	P35269,P55199,Q00403,P13984,P50750,Q92804,P29083,Q14241	8
Dna damage reversal	0.6012622326081395	1.0058837833554015	0.3144714779337039	1.0	0.795953563153691	6	Q8N9N2	1
Cellular response to chemical stress	0.3275445625248069	1.003592013603833	0.315575305630011	1.0	0.7972078243377709	80	P15954,Q8TED1,P28074,Q86X55,Q16881,Q8N8Q8,P20618,P62191,P60900,P28070,P49721,P00403,P67870,P30519,Q15648,P30043,Q9BX63,P20674,Q99436,P28072,P25787,O43242	22
Nef mediated downregulation of mhc class i complex cell surface expression	0.6362270303608022	1.0000317290194352	0.3172951531188714	1.0	0.7980922422922623	5	P56377	1
Regulation of ras by gaps	0.3594166926209333	0.9994199972268056	0.3175912766451456	1.0	0.7980922422922623	39	P28074,P28070,P49721,P28072	4
Interleukin 9 signaling	0.5646036916395221	0.9964328642577926	0.3190398716425568	1.0	0.7980922422922623	2	P42224	1
Interleukin 21 signaling	0.5646036916395221	0.9964328642577926	0.3190398716425568	1.0	0.7980922422922623	2	P42224	1
Cdc42 gtpase cycle	0.358755655620431	0.9937244697130176	0.3203570263797712	1.0	0.7980922422922623	39	Q9UQB8,Q8N5V2,Q86YQ8,Q13017	4
Diseases associated with glycosaminoglycan metabolism	0.5956867694639162	0.9824473456804668	0.3258795111207386	1.0	0.8076144406035698	6	P07686	1
Creb1 phosphorylation through nmda receptor mediated activation of ras signaling	0.5015977220234142	0.9737789276753118	0.3301663181096321	1.0	0.8168177140733087	10	Q15418,P51812,P07196	3
Regulation of hmox1 expression and activity	0.3413377682803233	0.9626847531757358	0.3357057504449887	1.0	0.8209848031546266	48	P67870,P28070,Q9BX63,P20618,P28074,P49721,Q99436,P62191,P28072,P25787,O43242,P60900	12
Regulation of runx2 expression and activity	0.3496061928100866	0.9585417886208462	0.3377896298844103	1.0	0.8214167620909295	43	P28070,P20618,P28074,P49721,Q99436,P49841,P62191,P28072,P25787,O43242,P60900	11
Interleukin 17 signaling	0.4149922546937729	0.9428902172493588	0.345737059248508	1.0	0.8305882671607302	19	O15111,P61088,P30154,P51812,Q15418	5
Activation of ampk downstream of nmdars	0.5569286396337227	0.9360793030604534	0.3492323584011969	1.0	0.8335948253294901	7	P54646,Q9BVA1	2
Collagen biosynthesis and modifying enzymes	0.4756887561737788	0.9333296312840218	0.3506498005414356	1.0	0.8355785380795079	11	P13674	1
Pyruvate metabolism and citric acid tca cycle	0.3640357554888295	0.929337421757452	0.3527142474180333	1.0	0.8390948289994951	34	P48735	1
Coenzyme a biosynthesis	0.631248864848033	0.9207766445599386	0.3571670510597724	1.0	0.846706061785739	3	Q96CD2	1
Hiv elongation arrest and recovery	0.4062541065646015	0.9194063005645696	0.3578830950151177	1.0	0.846706061785739	21	P35269,P55199,P50750,Q14241	4
Gaba synthesis release reuptake and degradation	0.5475027144408249	0.9179664580929756	0.3586364264578563	1.0	0.846706061785739	2	P51649	1
E3 ubiquitin ligases ubiquitinate target proteins	0.4153140671854612	0.9174926660672844	0.3588845342586571	1.0	0.846706061785739	17	P61088,Q149N8,Q14527,P50542	4
Lipophagy	0.6343936800958605	0.9078279504443711	0.3639691286819941	1.0	0.8532445180028048	4	P54646	1
Cdt1 association with the cdc6 orc origin complex	0.3473394638371527	0.9047847412952764	0.3655794368701976	1.0	0.8554198645977532	40	P28074,P28070,P49721,P28072	4
Rna polymerase ii transcribes snrna genes	0.3607455484067635	0.9030059054150996	0.3665227607446852	1.0	0.8562212033789779	34	P35269,Q8N201,Q8IXW5,Q00403,P55199,P13984,P50750,P29083,P52298	9
Mapk6 mapk4 signaling	0.3326606203310335	0.8999541691095196	0.3681446410444242	1.0	0.8572442737143847	49	O00231,Q9NZI8,P25787,P25685,P28070,P20618,P28074,P49721,Q9HCE1,Q99436,P06493,P62191,P28072,P60953,O43242,P60900	16
Caspase activation via extrinsic apoptotic signalling pathway	0.6319093859827589	0.8982869049062081	0.3690326120717835	1.0	0.8578653706399535	4	Q9UKG1	1
Ras processing	0.5458837381365051	0.887787017931245	0.3746553274060586	1.0	0.865574375442785	7	O60725	1
Assembly and cell surface presentation of nmda receptors	0.4634067886165528	0.869851927089003	0.3843813296161151	1.0	0.8790152349720622	11	Q9BVA1,P07196	2
Degradation of gli1 by the proteasome	0.3414019783930042	0.8632933944106689	0.3879761751152806	1.0	0.8796412670724588	41	P28074,P28070,P49721,P28072	4
Defective cftr causes cystic fibrosis	0.3373865500348836	0.8627514294137592	0.3882741491111479	1.0	0.8796412670724588	44	O94905,P28070,O75477,P28074,P20618,P49721,Q9UBV2,Q99436,P62191,P28072,P25787,O43242	12
Regulation of pten stability and activity	0.3373860207436005	0.862746714954841	0.3882767417463695	1.0	0.8796412670724588	44	P28070,P28074,P49721,Q99436,P28072	5
Sensory processing of sound by outer hair cells of the cochlea	0.4431058459893515	0.8529979871245121	0.3936604204474108	1.0	0.8835384056518982	13	P35241,P23634,P35579,Q01082,P15311,Q13813,Q12792	7
Maturation of sars cov 2 nucleoprotein	0.5644675150211259	0.8524175305027386	0.3939823936934548	1.0	0.8835384056518982	6	P49841,P49840	2
Diseases of immune system	0.6197420652855343	0.8517783207475472	0.3943371410488472	1.0	0.8835384056518982	4	P09429,O15111	2
Akt phosphorylates targets in the cytosol	0.5618862178090988	0.841780392652479	0.3999108890056617	1.0	0.8858308514924947	6	P49841,P49840	2
Phase i functionalization of compounds	0.4226100755503261	0.8409292086058993	0.4003875941074262	1.0	0.8858308514924947	15	Q16850,P30837,P07099	3
Collagen formation	0.4404943565354777	0.8388186199584208	0.4015711003032818	1.0	0.8858308514924947	13	P13674,Q32P28	2
Branched chain amino acid catabolism	0.4117525035594823	0.8337664995248958	0.4044125766227266	1.0	0.8858308514924947	16	Q96H78	1
Orc1 removal from chromatin	0.3235074444970824	0.8327387678853075	0.4049920750906959	1.0	0.8858308514924947	50	P33993,O00231,P33991,P25787,P28070,P20618,P28074,P49721,P20248,Q99436,Q13616,P62191,P28072,Q14566,O43242,P60900	16
Role of abl in robo slit signaling	0.6139972224701452	0.8299588494115834	0.4065620501420186	1.0	0.8858308514924947	4	Q7Z460,O75122	2
Signaling by erbb4	0.4466256954476105	0.8257896371688072	0.4089234335697747	1.0	0.8858308514924947	12	P78536	1
Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways	0.4195781798011679	0.8234613194641041	0.4102457049190193	1.0	0.887101865720186	15	O14920,P61088,Q14790,O15111	4
Fc epsilon receptor fceri signaling	0.3231805075468735	0.8205457058887888	0.4119050847415382	1.0	0.8879950767877336	61	P25787,O43242,P28074,P29353,P49427,P07948,P20618,P62191,P60900,P61088,P28070,P49721,O14920,Q13616,O43865,P19174,Q99436,P62993,P28072,O00459,O15111	21
Activation of ppargc1a pgc 1alpha by phosphorylation	0.604101468003325	0.8152136292708198	0.4149500376977171	1.0	0.8909081137240937	3	P54646	1
Transport of inorganic cations anions and amino acids oligopeptides	0.4444973451224125	0.814611594275912	0.4152946716805605	1.0	0.8909081137240937	12	Q70HW3	1
Toll like receptor tlr1 tlr2 cascade	0.3850280410399841	0.8138042155491648	0.4157571197379104	1.0	0.8909081137240937	23	O15111,P61088,P30154,P09429,P51812,Q15418	6
Cooperation of pdcl phlp1 and tric cct in g protein beta folding	0.4354953081353331	0.8117649924189987	0.4169264931955627	1.0	0.8920724516571725	13	P29992,P67870,P78371	3
Regulation of mrna stability by proteins that bind au rich elements	0.321295836211426	0.808488889259366	0.4188091996000926	1.0	0.8929102067047909	64	P31946,Q92945,Q01105,P28070,P20618,P28074,Q14103,P11940,P39687,P49721,Q04637,Q99436,P62191,P28072,P25787,O43242	16
Signaling by notch1 pest domain mutants in cancer	0.4514126796166439	0.8084155280529077	0.418851415901426	1.0	0.8929102067047909	11	P78536,P49768	2
Mitochondrial protein import	0.3373286311719828	0.8038643638424119	0.4214753128813613	1.0	0.8943105149485598	38	Q99595,Q9Y584,Q9Y5J7,Q15388,Q8N4Q1,O60830	6
Sars cov infections	0.3196544101670829	0.7986115197031215	0.4245157058918019	1.0	0.8943105149485598	66	P62942,P49840,Q9H0U3	3
Uptake and function of diphtheria toxin	0.6051782026858203	0.7966590737436998	0.4256490588750918	1.0	0.8943105149485598	4	P07900,Q16881	2
Interleukin 23 signaling	0.517643865363735	0.7835002969411166	0.4333333793828204	1.0	0.9001413525586761	2	P40763	1
Golgi cisternae pericentriolar stack reorganization	0.4451994822707456	0.7768528198142246	0.4372456095983632	1.0	0.9002185591025486	11	P14635,P06493,Q9H8Y8	3
Hdr through homologous recombination hrr	0.3588217085862736	0.775243686528367	0.4381956781485459	1.0	0.9002185591025486	30	Q9UQ84	1
E2f mediated regulation of dna replication	0.4443165519307297	0.7723839031118402	0.4398870847809109	1.0	0.9002185591025486	11	P14635,P30154,P06493	3
Sumo is transferred from e1 to e2 ube2i ubc9	0.5920900335113608	0.7692581745038972	0.4417400614489337	1.0	0.9002185591025486	3	P61956	1
Sumo is conjugated to e1 uba2 sae1	0.5920900335113608	0.7692581745038972	0.4417400614489337	1.0	0.9002185591025486	3	P61956	1
Fceri mediated ca 2 mobilization	0.5437039052996737	0.7674942255447704	0.4427877251351539	1.0	0.9002185591025486	6	P29353,O43865,P19174,P62993	4
Signaling by ctnnb1 phospho site mutants	0.49220913380642	0.766336525910576	0.4434760901684134	1.0	0.9002185591025486	8	P49841,P30154,Q13362	3
Beta catenin phosphorylation cascade	0.49220913380642	0.766336525910576	0.4434760901684134	1.0	0.9002185591025486	8	P49841,P30154,Q13362	3
Platelet sensitization by ldl	0.5151747838625054	0.7555510811628454	0.4499183951180514	1.0	0.9023029207113646	7	Q13362	1
Intrinsic pathway for apoptosis	0.3784328494692822	0.7543624536199518	0.4506316104312975	1.0	0.9023029207113646	22	P31946,Q9Y3B8,Q07812,Q96FJ2,P42771,Q07021,Q9NR28,Q14790,Q04917	9
Diseases of mismatch repair mmr	0.5880452373335117	0.7539062330284534	0.4509055276079092	1.0	0.9023029207113646	3	P52701	1
Abc family proteins mediated transport	0.3159708999827256	0.7482734221140727	0.4542952522733521	1.0	0.9043145228687812	56	O94905,Q9NP58,P28070,P08183,P20618,P28074,P05198,O75477,Q8NE71,P20042,P49721,Q9UBV2,Q99436,P62191,P28072,P25787,O43242	17
Mhc class ii antigen presentation	0.3149760878213741	0.7374663862028958	0.4608387772959919	1.0	0.9108117304393736	59	Q96FJ2,P52907,Q9BXS5,Q9Y496,Q9Y6G9,O75935,Q9Y6B6,Q9H0H5,Q13561,O95486,Q14203,Q9H0B6,Q9BVA1,Q13409,P52732,Q9UQ16,Q9NS87,Q9NSK0,Q9UJW0,P33176,Q07866,P56377	22
Rac1 gtpase cycle	0.3132857454178515	0.7333778491794195	0.4633280054697601	1.0	0.9131983510296102	51	Q9UQB8,Q8N5V2,Q13017	3
Arms mediated activation	0.5821341297855055	0.7315922995649976	0.4644174496815689	1.0	0.914081306348392	3	P46108,P31946	2
Response of eif2ak4 gcn2 to amino acid deficiency	0.3064568017784633	0.7208030193894079	0.471030717452344	1.0	0.9212689682359332	76	P18077,P62899,P62861,P46777,P42766,P05198,P35268,Q9Y3U8,P23396,P20042,P39023,P47914,P46779,P62917,P84098,P62913,P62424,P62851,P61254,P62847,P08243,P62263,P62841,P62750,P61513	25
Activation of bad and translocation to mitochondria	0.4811747816777688	0.71717059881696	0.4732688383221024	1.0	0.9212689682359332	8	Q04917,P31946,P62258,Q9Y3B8	4
Signaling by cytosolic fgfr1 fusion mutants	0.4646837570263573	0.7142599446599254	0.4750664557775022	1.0	0.9212689682359332	9	O15164,Q16630,Q92614,O95684,P62993,P42224	6
Processing and activation of sumo	0.5798312491267618	0.7025050065221039	0.4823642805874994	1.0	0.930671996625776	4	P61956	1
Activation of nima kinases nek9 nek6 nek7	0.5796862191284137	0.7019738232660961	0.4826954882706222	1.0	0.930671996625776	4	P14635,P06493	2
Constitutive signaling by akt1 e17k in cancer	0.5014281216625974	0.6976397268788631	0.4854025305509828	1.0	0.930671996625776	7	P49841,P49840	2
Toll like receptor 9 tlr9 cascade	0.3617328945437603	0.6933519116199873	0.4880887327499541	1.0	0.933590432917033	25	O15111,P61088,P30154,P09429,P51812,Q15418	6
Rho gtpases activate iqgaps	0.4269592976862885	0.6854806672783729	0.4930406560406508	1.0	0.937779388240518	11	P46940,Q9BVA1,Q13576	3
Glycogen storage diseases	0.5695591750069371	0.6846447850706728	0.4935680990739568	1.0	0.937779388240518	3	P46976	1
Hiv transcription elongation	0.3570055847665595	0.6781291200783416	0.4976898286962055	1.0	0.94059417227068	26	P35269,P55199,P13984,P50750,Q14241	5
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.4247473253187158	0.6745509216196165	0.499961123111416	1.0	0.9412759255286394	11	P56377	1
Regulation of expression of slits and robos	0.2758709382304464	0.671832987849045	0.5016900254548027	1.0	0.9412759255286394	124	P18077,P61513,P62899,P62861,P46777,P42766,P28074,Q9BZI7,P11940,P35268,Q9Y5S9,Q9Y3U8,P23396,P20618,P39023,P47914,P46779,P62917,P62913,P62424,P84098,P62191,Q15287,P52298,P60900,O00231,P62851,P28070,P49721,P61254,P62847,P62750,Q04637,Q99436,P62841,P62263,P28072,P25787,O43242	39
Abc transporter disorders	0.3113091723607583	0.671324505237381	0.5020138269486076	1.0	0.9412759255286394	47	O94905,Q9NP58,P28070,O75477,P28074,P20618,P49721,Q9UBV2,Q99436,P62191,P28072,P25787,O43242	13
Eukaryotic translation initiation	0.281771311644282	0.6681291847880627	0.5040511338090354	1.0	0.9438539627830164	101	O75821,P18077,P62899,P62861,P46777,P42766,P05198,Q14152,P35268,P11940,P55010,Q15056,Q9Y3U8,P23396,P20042,P39023,P47914,P46779,P62917,P62913,P62424,P84098,P62851,O75822,P61254,P62847,O15372,P62750,Q04637,P23588,P62841,P62263,P61513	33
Processing of capped intron containing pre mrna	0.2594187042156866	0.6619086848341786	0.5080297455046177	1.0	0.9500556264358008	190	Q86V81,P35269,Q13151,O75940,Q92620,O43390,Q9BZI7,Q13242,O43395,Q9H2H8,P67809,O75152,Q8N1F7,P55795,Q8N684,P31943,P13984,Q07955,P52298,Q15287,Q8IYB3,P61978,P22626,Q14103,P82979,Q86U42,P38159,O43290,Q7L014,Q13573,P52597,P12270,O75494,Q6UN15,P42285,O15504,P62995,Q96FV9,Q9Y3Y2,Q99459,Q15459,Q92733,Q9BUJ2,Q9Y2W2,Q16629,Q15427,P51991,P35637	48
Amino acid transport across the plasma membrane	0.5485366596524655	0.6596270449530941	0.5094931943457741	1.0	0.9515436460586214	5	P08195,Q9H2J7	2
Notch3 intracellular domain regulates transcription	0.5671102672833546	0.6562870389278318	0.5116394553495593	1.0	0.9530538874158458	4	Q13573	1
Rho gtpases activate ktn1	0.451264439249029	0.6531202217083113	0.5136787766133004	1.0	0.9553066216417416	9	Q9NSK0,Q07866,Q9H0B6,P60953,Q86UP2	5
Mapk family signaling cascades	0.2816856476630192	0.6421267176690764	0.520790909628265	1.0	0.9588204731528136	98	Q15008,P60953,Q13362,P28074,O60725,P31946,P29353,P25685,P30086,P18206,P20618,P46940,P30154,P62191,Q13813,P60900,Q02750,O00231,P28070,Q96P70,Q9NWH9,P49721,P06493,O43924,P07196,Q13555,Q9NZI8,Q6UWU4,O00459,Q9HCE1,Q99436,P62993,P28072,P25787,O43242	35
C type lectin receptors clrs	0.3048104013830859	0.6399268887805857	0.5222201318947488	1.0	0.9602112102580864	58	O15111,P49427,P61088,P28070,O43865,P20618,P28074,O14920,P49721,Q99436,Q8TBC4,P62191,P28072,P25787,Q14790,O43242,P60900	17
Transport of small molecules	0.2647958871413454	0.6379664441858391	0.5234955236786014	1.0	0.9613158778891844	169	Q70HW3,Q9H0U3,Q9NP58,P28070,P08183,P28072,Q9H2J7,P28074,P05198,P53985,P49721,Q15043,Q99436,Q9HD20,Q9C0H2,Q8WTV0,O00400	17
Uch proteinases	0.3032845584491143	0.6289361341691555	0.5293908686039921	1.0	0.9693795433491464	49	Q8NB78,P28070,P28074,P49721,P28072	5
Homology directed repair	0.3032696636914712	0.6288031272084096	0.529477952467611	1.0	0.9693795433491464	49	Q9NR33,Q9UQ84,Q9NXR7,P41440,P61088,Q9BX63,Q9UGN5,Q9Y2S7,P49959	9
G2 m checkpoints	0.2838858323408193	0.6269269786166466	0.5307071018244389	1.0	0.9693795433491464	91	P14635,Q9UQ84,Q9Y3B8,P28074,Q14566,P30307,P20618,P28070,P61088,P49721,P06493,P49959,O14757,Q9NXR7,Q9BX63,Q99436,P28072,O43242,Q99640	19
Chl1 interactions	0.5526995780686559	0.6229628295852614	0.5333089483463835	1.0	0.9693795433491464	3	O14786	1
Dual incision in gg ner	0.3508433303560085	0.6212396030205963	0.5344419858164402	1.0	0.9693795433491464	25	P41440,Q9UGN5	2
O linked glycosylation	0.5562665908792057	0.6175358200580707	0.5368813622486845	1.0	0.9693795433491464	4	Q86SF2,Q10472	2
O linked glycosylation of mucins	0.5562665908792057	0.6175358200580707	0.5368813622486845	1.0	0.9693795433491464	4	Q86SF2,Q10472	2
Transcriptional regulation by runx3	0.3099675768042439	0.6145337245233545	0.538862694654068	1.0	0.9693795433491464	43	P28070,P28072,P20618,P28074,P49721,Q99436,P42771,P62191,Q13573,P25787,O43242	11
Rna polymerase ii transcription termination	0.3030619651247241	0.6124450081124391	0.5402433712315289	1.0	0.9693795433491464	48	Q13243,Q86V81,Q9BZI7,Q92620,Q13242,Q9Y5S9,O75152,Q8N684,Q07955,P52298,Q15287,P84103,Q8IYB3,Q9BY77,Q96QD9,P82979,Q86U42,Q6UN15,Q96FV9,Q9Y3Y2,Q01130,Q16629	22
Inhibition of replication initiation of damaged dna by rb1 e2f1	0.5033701534913623	0.6079849982204152	0.5431974236713275	1.0	0.9693795433491464	6	P30154	1
Mapk targets nuclear events mediated by map kinases	0.4253674943262712	0.6042025261493531	0.545709001641189	1.0	0.9693795433491464	10	P30154,P51812	2
Erk mapk targets	0.4253674943262712	0.6042025261493531	0.545709001641189	1.0	0.9693795433491464	10	P30154,P51812	2
G1 s dna damage checkpoints	0.3096110216579978	0.6030622759169755	0.5464672610799064	1.0	0.9693795433491464	42	P28070,P20618,P28074,P49721,Q99436,P42771,O14757,P62191,P28072,P25787,O43242	11
Tysnd1 cleaves peroxisomal proteins	0.5019988217245053	0.6027232762622144	0.5466927943942665	1.0	0.9693795433491464	6	P51659,P22307,O00116,Q15067	4
Caspase mediated cleavage of cytoskeletal proteins	0.5010277631224838	0.5990048466379428	0.549169652599256	1.0	0.9693795433491464	6	P35611,P08670,Q14790	3
Signaling by alk in cancer	0.3124977708442603	0.5972414938632074	0.5503461596042483	1.0	0.9693795433491464	37	Q92734,Q8IWJ2,P29353,Q9HC35,P35579,P51608,P10644,P18206,Q14203,Q9P2E9,P19174,Q07866,P33176,P62993,P12270,Q13616	16
Long term potentiation	0.5308135313845012	0.5946457855653716	0.5520802681623276	1.0	0.9693795433491464	5	Q13555,P07196	2
Unblocking of nmda receptors glutamate binding and activation	0.5308135313845012	0.5946457855653716	0.5520802681623276	1.0	0.9693795433491464	5	Q13555,P07196	2
Translation of sars cov 1 structural proteins	0.4744699815361375	0.5872192493231445	0.5570564659167538	1.0	0.972864467801512	7	P49840	1
Sphingolipid metabolism	0.340721834225219	0.5857914304067816	0.5580156832368597	1.0	0.9732831684363832	27	O15121,P07686,Q96G23	3
N glycan trimming in the er and calnexin calreticulin cycle	0.3575472350831518	0.5764963144772086	0.5642797602696281	1.0	0.980608119980756	18	Q9UKV5,Q04323,Q9UBV2,P54727	4
Rora activates gene expression	0.5387581300161794	0.5732163674287651	0.5664982035378225	1.0	0.9823388761271586	3	Q15648	1
Signaling by notch1	0.3741278584461008	0.5694846833509537	0.5690272622228676	1.0	0.9824135388415014	15	P78536,P49768,Q04727	3
Stabilization of p53	0.3070176353158432	0.5682415636453412	0.5698709524247478	1.0	0.9824135388415014	40	P28074,P28070,P49721,P28072	4
Tp53 regulates transcription of cell cycle genes	0.3538067477138998	0.5631468937288465	0.5733348617379828	1.0	0.9824135388415014	19	P14635,Q9Y3B8,Q07812,P30307,P06493,Q9C0C2	6
Tcf dependent signaling in response to wnt	0.2960168998852265	0.5592926726619422	0.5759619952424861	1.0	0.9824135388415014	65	Q04727,P28070,Q13362,P28074,P49721,P30154,Q99436,O14641,P28072	9
Downregulation of erbb2 erbb3 signaling	0.4633550488599348	0.5524776375590004	0.5806211515100683	1.0	0.982581875771108	2	P31751	1
Rho gtpase cycle	0.2540424259337082	0.5472695957003975	0.5841935288796849	1.0	0.982581875771108	179	O14964,O75886,Q86Y07,Q9UQB8,Q9H0H5,Q9NYL9,P41440,Q8N684,Q86YQ8,Q13576,Q5T8D3,Q03001,Q13017,Q99707,Q8N5V2,Q16543,Q8IYB3,P08670,P80723,P78371,P38159,P30519,O75116,O15173,Q99569,Q9HD26,Q8NBN3,Q9UDY2,Q9Y266,P62995,Q12792,O00459,O43396	33
Ikba variant leads to eda id	0.530138238562997	0.5431019309862695	0.587059623199595	1.0	0.982581875771108	3	O15111	1
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1	0.2917875506148507	0.5422020718578984	0.5876793081802942	1.0	0.982581875771108	50	P28070,P20618,P28074,P49721,Q99436,P60900,P53350,P62191,P28072,P25787,Q9UJX2,O43242,Q16763	13
Hedgehog on state	0.3007753371388496	0.5389528268336171	0.58991940483816	1.0	0.982581875771108	43	P28074,P28070,P49721,P28072	4
Apc c mediated degradation of cell cycle proteins	0.2933764726304333	0.533523571564528	0.5936711985266081	1.0	0.982581875771108	58	P14635,P28074,Q9UJX4,Q9UJX2,Q16763,P20618,P53350,P62191,P60900,O00231,P28070,Q9H1A4,P49721,P06493,Q13616,P20248,Q99436,P28072,P25787,O43242	20
Transcriptional regulation by tp53	0.2657702532987747	0.5292139135882321	0.5966570658546777	1.0	0.982581875771108	143	P14635,P15954,Q9UQ84,Q9Y3B8,P35269,Q13362,Q9C0C2,Q07812,Q8N8Q8,P30307,P13984,P30154,P42771,P54646,Q14241,Q92696,P55199,Q8TBX8,Q9UER7,P00403,P06493,P49959,P50750,Q92804,P67870,Q9H9B1,Q9BX63,P20674,Q9HCE1	29
G2 m dna damage checkpoint	0.3020229517804716	0.5287562555289238	0.5969745469712191	1.0	0.982581875771108	40	P14635,Q9UQ84,Q9Y3B8,Q9NXR7,P61088,Q9BX63,P30307,P06493,P49959	9
Dna replication initiation	0.4583973654987613	0.5238564953910064	0.6003783555542284	1.0	0.982581875771108	7	Q9NR33	1
Zbp1 dai mediated induction of type i ifns	0.4809849661072997	0.5237483985877941	0.6004535480395681	1.0	0.982581875771108	6	Q9UHD2,O15111	2
Cytokine signaling in immune system	0.2516500904472235	0.5170972855704052	0.6050882483907327	1.0	0.9855035602269094	191	O15111,P60953,P14174,P52907,P28074,Q8TBC4,P43378,Q9H3K6,O14979,Q15418,Q8N1F7,P10321,P20618,P30154,P09429,P11233,P78344,P78536,P62191,Q13126,P19474,P60900,P52292,Q93034,P28070,P61088,P22626,P08670,Q9H0E2,P49721,Q9UII4,P51812,O00170,O14920,P52597,P12270,Q13616,Q13555,Q9UHD2,O15504,O00459,P19174,Q04637,Q99436,P62993,P28072,P25787,O43242	48
Nucleotide salvage	0.4333771510524461	0.5133934976653872	0.6076760931106375	1.0	0.9855035602269094	8	Q9BZX2	1
Rho gtpase effectors	0.2651621031934002	0.5128890013405616	0.6080289675237998	1.0	0.9855035602269094	131	Q8NFH4,Q9Y3B8,P60953,Q9UQB8,Q96FJ2,Q13362,Q9BZD4,Q9Y6G9,O43683,Q8NBT2,P35580,P31946,P30307,P46940,P30154,P53350,Q13576,O14641,Q9H0B6,P59998,Q8WYP5,Q9BVA1,Q7Z460,Q13409,Q9NZQ3,Q71F23,Q9Y6D9,O75116,Q7Z406,Q9HD26,P35579,P49454,Q9NSK0,Q07866,Q9Y266,P62993,O14777,Q86UP2,Q8WUW1	39
Termination of translesion dna synthesis	0.3462702557841886	0.5113951139028153	0.6090744156016663	1.0	0.9855035602269094	18	P41440	1
Apoptotic cleavage of cellular proteins	0.3425511382622184	0.5062048062355404	0.6127128813387459	1.0	0.9855035602269094	20	P08670,Q9UDY2,P35611,Q9P289,Q13813,P20700,Q14790,Q16625	8
Met activates ras signaling	0.475915572385909	0.505204921027757	0.6134149143250629	1.0	0.9855035602269094	6	P29353,Q9NWH9,P62993	3
Rhob gtpase cycle	0.3258467412702651	0.5041950424481528	0.6141243238466636	1.0	0.9855035602269094	28	Q9H0H5,P41440,Q9UDY2,O00459,Q13017	5
Carboxyterminal post translational modifications of tubulin	0.4752717391304468	0.5028651826036287	0.6150590617202196	1.0	0.9858933216550202	6	P68371,Q13885,Q9BVA1,Q14166,P04350	5
Diseases of mitotic cell cycle	0.3679753616685955	0.4984439774255985	0.6181711465237438	1.0	0.9868587828172004	14	Q9H1A4,Q9UER7,P11802,Q00534,Q9UJX2,Q16763	6
G1 s specific transcription	0.3812472841678872	0.4970921977743835	0.6191240363779489	1.0	0.9868587828172004	12	P00374,P04818,P06493	3
Neutrophil degranulation	0.2502908751866027	0.4932928233000441	0.6218056985703129	1.0	0.9886989162039024	191	P46976,Q9H0U3,P50395,P14174,P68402,Q9BXS5,P09960,O43681,Q9Y6G9,Q8N2G8,Q9Y5K8,O75874,P07686,P10321,P20618,O15121,P09429,Q13576,Q14019,P08236,P78371,P67870,P30519,O15260,Q9H7Z7,O15078,Q96BM9,Q9NQX7,Q99436,P04066,Q9Y376,Q14165,P49768,Q07065,O43242	35
Golgi to er retrograde transport	0.2845928901816885	0.4894588870134534	0.6245168545202668	1.0	0.9886989162039024	76	Q96FJ2,P68402,P52907,P61163,Q9BW19,Q9Y496,Q9Y6G9,Q9P2W9,O75935,Q6NUQ1,Q15042,Q12981,Q9H0H5,Q13561,Q14203,Q9H0B6,P61923,Q10472,Q8TD16,Q9BVA1,Q13409,Q9H0U4,P52732,O15260,Q9NS87,Q9NSK0,Q9UJW0,P33176,Q07866,O14579,Q92538,P24390	32
Rhoa gtpase cycle	0.2874226434178689	0.4863814940969903	0.626696708893647	1.0	0.9886989162039024	55	Q9Y4F1,O15173,Q8N5V2,Q9H0H5,P41440,Q8NBN3,Q9UDY2,O00459,Q5T8D3,P30519,O75116,Q13017	12
Switching of origins to a post replicative state	0.288386755115955	0.4859886642227817	0.6269752031135982	1.0	0.9886989162039024	60	P33993,P33991,P28074,Q9UJX4,Q14566,Q9UJX2,Q16763,P20618,P62191,P60900,O00231,P28070,Q9H1A4,P49721,Q13616,P20248,Q99436,P28072,P25787,O43242	20
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components	0.4459826275787186	0.4839410750179386	0.6284276885089395	1.0	0.9886989162039024	2	P12814	1
Cell death signalling via nrage nrif and nade	0.3712697370044062	0.4807617546746351	0.6306858349679629	1.0	0.9886989162039024	13	Q8N5V2	1
Signalling to ras	0.4967225713966924	0.4754289076145346	0.6344812942011675	1.0	0.9909677133271751	5	P11233,P62993	2
Epha mediated growth cone collapse	0.3824620303088658	0.4741768507549518	0.6353737997005	1.0	0.9909677133271751	11	Q7Z406,P35580,Q8N5V2,P35579,Q15375,O75116	6
Intraflagellar transport	0.3558501379056589	0.4734738498659452	0.6358751532583518	1.0	0.9909677133271751	15	Q8NCM8,A0AVF1,Q96FJ2,Q9BVA1	4
Vitamin b5 pantothenate metabolism	0.4666541642270966	0.4718960322667699	0.6370010002861	1.0	0.9909677133271751	6	Q9NRN7,Q96CD2	2
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1	0.4923598609931829	0.4608190875298237	0.6449284061878786	1.0	0.9966563805750888	5	P06493,Q5TKA1	2
Signaling by hedgehog	0.2851839024592629	0.4558885392135543	0.6484701313427517	1.0	0.9974788984994926	63	P48729,Q15008,P28074,Q9Y496,P10644,P20618,P62191,P78536,P60900,O00231,P28070,Q9BVA1,P49721,P49841,Q13616,Q8NCM8,Q9UBV2,Q99436,P28072,P25787,O43242	21
Recognition of dna damage by pcna containing replication complex	0.3358378623276214	0.4529393657126044	0.6505924035309536	1.0	0.9990238955081991	18	P41440	1
Cargo trafficking to the periciliary membrane	0.3328254921349798	0.4502145024207683	0.6525557802291249	1.0	1.0	20	Q8TAG9,Q8IYI6,P78371,Q9UPT5,A6NIH7,O43924	6
Notch1 intracellular domain regulates transcription	0.4029001852674695	0.4451114830751746	0.6562391907513094	1.0	1.0	9	Q04727	1
Met activates ptpn11	0.5005687439992681	0.4441323362086569	0.6569469089161548	1.0	1.0	3	Q9NWH9	1
Dna damage recognition in gg ner	0.3311613989943374	0.4408082962794389	0.659351786919586	1.0	1.0	20	Q9H9Q2,P54727,P41208,Q9UGN5,Q99627	5
Cell cycle checkpoints	0.2567064633379012	0.4405040381696659	0.6595720882079172	1.0	1.0	158	P14635,P33991,Q9UQ84,P25787,Q9Y3B8,Q96FJ2,Q13362,P28074,Q9BZD4,Q9Y6G9,O43683,Q14566,Q9UJX2,Q16763,Q8NBT2,P31946,P30307,P20618,P30154,P53350,P42771,P62191,P60900,Q8WYP5,P28070,P61088,Q9H1A4,Q7Z460,Q13409,P49721,P06493,P49959,Q71F23,O14757,Q9Y6D9,O96028,Q9NXR7,Q9BX63,O00311,Q9Y266,Q99436,P28072,O14777,O43242,Q99640	45
Metabolism of vitamins and cofactors	0.2811615704396801	0.4388096001696812	0.660799503554168	1.0	1.0	53	O75874,P00374,Q9NRN7,P41440,Q969G6,Q6NUM9,Q9H2D1,P43490	8
Formation of incision complex in gg ner	0.3331733401890664	0.4383157211643507	0.6611574311050878	1.0	1.0	18	P61088,Q9UGN5,P41208	3
Polymerase switching	0.3554887137030623	0.4368432016650788	0.6622250657193545	1.0	1.0	14	P41440,P49642	2
Resolution of ap sites via the multiple nucleotide patch replacement pathway	0.3251846042577668	0.4345035550699917	0.6639228137864144	1.0	1.0	23	P41440,Q9UGN5	2
Intra golgi and retrograde golgi to er traffic	0.2596958462336429	0.4316439698716326	0.6660001959117783	1.0	1.0	106	Q96MW5,Q5VZE5,Q96FJ2,P68402,P52907,P61163,Q9BW19,Q9Y496,Q9P2W9,Q9Y6G9,P82094,Q6NUQ1,O75935,Q15042,Q12981,Q8IWJ2,Q9H0H5,Q13561,Q14203,Q10471,Q9H0B6,P61923,Q10472,Q8TBA6,Q8WTW3,Q8TD16,Q9BVA1,Q13409,Q9H0U4,P52732,O15260,O15498,P20645,Q9NS87,Q9NSK0,Q9UJW0,O14653,Q07866,P33176,O14579,O60499,Q92538,P24390	43
Signaling by type 1 insulin like growth factor 1 receptor igf1r	0.4102304155861992	0.4221122129968794	0.6729431139434889	1.0	1.0	8	P29353,O00459,O14654,P62993	4
Separation of sister chromatids	0.2560778070819932	0.4214780194268827	0.6734060584992032	1.0	1.0	115	O14777,Q8NFH4,Q96FJ2,Q13362,P28074,Q9BZD4,Q9Y6G9,O43683,Q9UJX2,Q16763,Q8NBT2,P20618,P30154,P53350,P62191,P60900,Q8WYP5,P28070,Q9BVA1,Q9H1A4,Q7Z460,Q13409,P49721,Q71F23,Q9Y6D9,P49454,Q9Y266,Q99436,P28072,P25787,O43242	31
Signaling by fgfr in disease	0.3210748468296889	0.4213814012244818	0.6734765981024855	1.0	1.0	24	O94905,P35269,O15164,P52298,O95429,Q92614,P19174,P13984,P42224,P62993,P24928,P19388,O95684	13
Vitamin d calciferol metabolism	0.4920666353091373	0.4170777761389618	0.6766215198174528	1.0	1.0	3	P38435	1
Transcriptional regulation by e2f6	0.3633389567996251	0.4149309271433978	0.6781924687649408	1.0	1.0	12	P31350,Q9H9B1,Q15910,O00311,O14757	5
Selective autophagy	0.2906467678221424	0.4121369603828019	0.6802390395003672	1.0	1.0	36	P61088,Q8IWA4,Q96FJ2,P08670,Q13409,Q15388,Q9Y6G9,P54646,P67870,P50542	10
Regulation of tp53 activity	0.2802971597056882	0.4119876155740209	0.6803485005491732	1.0	1.0	64	Q9UQ84,Q9H9B1,Q9BX63,Q13362,Q8TBX8,Q9UER7,P30154,P06493,P42771,P49959,P54646,P67870,Q92804	13
Cellular response to starvation	0.2650163448185996	0.4066889495648198	0.6842364576439897	1.0	1.0	91	P18077,P62899,P62861,P46777,P42766,P05198,P35268,Q9Y5K8,Q9Y3U8,P21281,P23396,P20042,P39023,P47914,P46779,P42345,P62917,P62913,P62424,P84098,P62851,P61254,P62847,P62750,P08243,P62841,P62263,P61513	28
Mitotic telophase cytokinesis	0.3613717961814022	0.4061936643693872	0.6846003088902037	1.0	1.0	12	Q6KC79,Q9Y6X3	2
Translesion synthesis by y family dna polymerases bypasses lesions on dna template	0.3235003637293754	0.4059131270162391	0.6848064324609504	1.0	1.0	21	P41440	1
Nuclear events kinase and transcription factor activation	0.3552294775072064	0.4054292278905034	0.6851620303453321	1.0	1.0	13	P30154,P51812	2
Signaling by wnt	0.2635122486338853	0.4045962182618904	0.6857743388029887	1.0	1.0	95	Q5T9L3,Q04727,P28070,Q13362,P28074,P49721,Q9HCE1,Q99436,P30154,O14641,P67870,P28072	12
Sema4d in semaphorin signaling	0.3918709510593834	0.401233648515843	0.6882481093352992	1.0	1.0	9	Q9NWH9,Q7Z406,P35580,O75116	4
Sulfur amino acid metabolism	0.3916303390712919	0.400294265169242	0.6889397913873503	1.0	1.0	9	Q99707,Q13126	2
Striated muscle contraction	0.4447179551147283	0.3962561263362503	0.6919160898768619	1.0	1.0	6	Q9NYL9,P08670	2
Rhof gtpase cycle	0.3211295864659266	0.3927082340578201	0.6945349883834055	1.0	1.0	21	P80723,Q02952,O00459,Q13017	4
Irf3 mediated induction of type i ifn	0.4403227691039846	0.3817055187437873	0.7026798061322674	1.0	1.0	6	Q9UHD2	1
Esr mediated signaling	0.2744623725818069	0.3743706441336581	0.7081285802303707	1.0	1.0	48	P35269,Q9HCL2,Q15648,P50750	4
Perk regulates gene expression	0.3478608081591696	0.3722110933483323	0.7097356872397671	1.0	1.0	13	Q92945,P20042,P05198,Q13868,P08243	5
Signaling by robo receptors	0.2549577981927621	0.3704411052266168	0.7110538512070566	1.0	1.0	138	P18077,P61513,P62899,P62861,P60953,P46777,P42766,P28074,Q9BZI7,P11940,P35268,Q9Y5S9,Q9Y3U8,P23396,P20618,P39023,O14786,P47914,P46779,P62917,P62913,P62424,P84098,P62191,Q15287,P52298,P60900,O00231,P62851,P28070,Q7Z460,P49721,P61254,P62847,P62750,Q04637,Q99436,P62841,P62263,P28072,P25787,O43242	42
Signal attenuation	0.480269095889341	0.3686793615068428	0.712366733863955	1.0	1.0	4	P62993	1
Translocation of slc2a4 glut4 to the plasma membrane	0.2811124455844772	0.3684197751067221	0.7125602544410539	1.0	1.0	39	Q8TAG9,P31946,Q86YS7,Q9Y3B8,Q8IYI6,P54646,P35579,Q9BVA1,Q9Y496,P11233,Q9UPT5,Q9UIQ6,Q04917	13
Diseases of signal transduction by growth factor receptors and second messengers	0.2488858080319723	0.3680039962852687	0.7128702543750043	1.0	1.0	167	P48729,O15111,P35269,P51114,Q13362,P28074,P62942,Q8IWJ2,P31946,P29353,O15164,P30086,P18206,P20618,Q14203,P07948,P10644,P46940,P30154,P13984,P42345,P78536,P62191,P49840,P52298,O95684,P60900,Q02750,Q16543,P28070,O95429,Q9NWH9,P49721,P49841,Q13573,P12270,Q13616,O94905,Q13555,Q92734,Q6UN15,P35579,P51608,O00459,P19174,Q07866,Q9P2E9,Q9UBV2,Q99436,P62993,P49768,P28072,P25787,Q9NRY5,O43242	55
Cellular response to hypoxia	0.279022632240814	0.3650739983822029	0.7150561696407798	1.0	1.0	42	P28074,P28070,P49721,P28072	4
Formation of tubulin folding intermediates by cct tric	0.3455198999993942	0.3618584979540993	0.7174577750071922	1.0	1.0	13	P78371	1
Senescence associated secretory phenotype sasp	0.3095653043360007	0.3551649245996707	0.7224660400793825	1.0	1.0	24	Q9H9B1,Q9H1A4,P42771,Q9UJX4,P11802,P51812,Q00534,Q9UJX2,Q15418,Q16763	10
Signaling by nuclear receptors	0.2731129682327242	0.3512955819146344	0.7253666091217381	1.0	1.0	61	Q8NB78,Q15648,P35269,P50750,Q9HCL2	5
Phenylalanine and tyrosine metabolism	0.4726270430671825	0.3464564060879116	0.7289997407478639	1.0	1.0	4	P61457	1
P75 ntr receptor mediated signalling	0.3123991054065584	0.3451931995707101	0.7299491308815451	1.0	1.0	21	P78536,Q8N5V2	2
Signaling by wnt in cancer	0.3621153310928901	0.3348130991191645	0.7377660786015958	1.0	1.0	10	P49841,P30154,Q13362	3
Trans golgi network vesicle budding	0.2753344065125322	0.3344484908214741	0.7380411534889619	1.0	1.0	41	O60749,Q9H3P7,O14976,P20645,P78537,Q9BXS5,O95295,P56377,O14964,O75976,Q92572	11
Traf6 mediated nf kb activation	0.3858781276605726	0.3331632573377006	0.7390110516580566	1.0	1.0	8	P09429,O15111	2
Downregulation of erbb2 signaling	0.4050302108842444	0.3317589703651128	0.7400712680803998	1.0	1.0	7	Q93034,P31751,Q16543	3
Apoptotic cleavage of cell adhesion proteins	0.4217366209715705	0.3226618877782031	0.7469513186570236	1.0	1.0	6	Q16625	1
Nonsense mediated decay nmd	0.2593705729541663	0.3190988284991084	0.7496515719872607	1.0	1.0	87	P18077,P62899,P62861,P46777,P42766,Q9BZI7,P11940,P35268,Q9Y5S9,Q9Y3U8,P23396,P39023,P47914,P46779,P84098,P62917,P62913,P62424,P52298,Q15287,P63151,P62851,P61254,P62847,P62750,Q04637,P62841,P62263,P61513	29
M phase	0.2462378762063663	0.317606244091201	0.7507836371186085	1.0	1.0	211	Q8IXJ6,P14635,P25787,Q86Y07,Q01105,Q96FJ2,Q13362,P28074,Q9BZD4,Q9Y6G9,Q9UQN3,O43683,Q15154,Q9UJX2,O75935,Q16763,Q8N1F7,Q8NBT2,Q9Y6X3,Q7Z4H7,Q13561,P20618,Q14203,P50402,P30154,P53350,P62191,O95684,P60900,Q8WYP5,P28070,Q9BVA1,Q9NTJ3,Q7Z460,Q96CS2,Q13409,P49721,P06493,Q71F23,P67870,Q9Y6D9,O43805,P12270,Q6KC79,O15078,Q96RT8,O15504,P41208,Q9H8Y8,Q9Y266,Q99436,P28072,O14777,O43242	54
Golgi associated vesicle biogenesis	0.2828484259135427	0.3146745981607876	0.7530087328908712	1.0	1.0	33	Q9H3P7,O14976,P78537,Q9BXS5,O95295,P56377,O75976,Q92572	8
Platelet homeostasis	0.3289051425701906	0.3145269424711545	0.7531208568420431	1.0	1.0	14	Q13586,Q13362	2
Rhoc gtpase cycle	0.2780547791426556	0.3109861021608961	0.7558111870223416	1.0	1.0	35	Q9H0H5,P41440,Q9UDY2,P46940,Q5T8D3,O75116,Q13017	7
Phosphorylation of the apc c	0.3326075599519794	0.3066227746640765	0.7591305164827067	1.0	1.0	13	P14635,Q9H1A4,P06493,P53350,Q9UJX2,Q16763	6
Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants	0.4418345956245109	0.3050471815457158	0.7603302180370537	1.0	1.0	5	O00459,P62993	2
Activation of bh3 only proteins	0.3406960844993654	0.2991456432025156	0.7648289216105799	1.0	1.0	11	P31946,P62258,Q9Y3B8,Q96FJ2,Q04917	5
Dna damage bypass	0.30081432393045	0.2986398744273608	0.7652148376362664	1.0	1.0	23	P41440	1
Signaling by erbb2 ecd mutants	0.3942834439969512	0.2973142335714044	0.7662266158856199	1.0	1.0	7	P29353,P19174,Q16543,P62993	4
Signaling by erbb2 in cancer	0.3942834439969512	0.2973142335714044	0.7662266158856199	1.0	1.0	7	P29353,P19174,Q16543,P62993	4
Pyroptosis	0.3751642021187613	0.2967236960599487	0.7666774645195258	1.0	1.0	8	Q07812,P09429	2
Signaling by fgfr4 in disease	0.4505591432945992	0.295761876149894	0.7674119395116032	1.0	1.0	3	P19174	1
Activated notch1 transmits signal to the nucleus	0.4118904973115049	0.2931334456061458	0.7694201531475826	1.0	1.0	6	P78536	1
Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s	0.2618466339983247	0.2930481800878325	0.7694853250001994	1.0	1.0	51	O75821,P62851,P62861,P23396,O75822,P20042,P55884,P05198,P11940,Q14152,Q04637,P60228,P23588,P62841,P62847,O15372,P62263,Q15056	18
Circadian clock	0.3383385516402903	0.2901659639922061	0.7716892733677705	1.0	1.0	11	Q86X55,P43490,Q15648	3
Dag and ip3 signaling	0.3720679044509209	0.2865281887470148	0.7744736065755113	1.0	1.0	8	P52292,Q13555,O43865,P19174	4
Oxidative stress induced senescence	0.3036577742240515	0.2863846128097985	0.7745835585952272	1.0	1.0	18	Q9HC52,Q9HCE1,P42771,P11802,Q00534	5
Regulation of localization of foxo transcription factors	0.4073832660050374	0.2800477718681868	0.779440853955095	1.0	1.0	6	P31946,Q9Y3B8	2
Apoptotic execution phase	0.2797969300534676	0.2797659936738458	0.7796570433667753	1.0	1.0	32	P26583,P08670,Q9UDY2,P35611,P09429,Q14790,Q16625	7
Eukaryotic translation elongation	0.2623733599263255	0.2797539508267397	0.7796662834113417	1.0	1.0	77	P18077,P62899,P62861,P46777,P42766,P35268,Q9Y3U8,P23396,P39023,P47914,P46779,P84098,P62917,P62913,P62424,P62851,P61254,P62847,P62750,P29692,P62841,P62263,P61513	23
Mapk3 erk1 activation	0.4478631042168797	0.2788403365853709	0.780367357516554	1.0	1.0	4	P06493	1
Rhod gtpase cycle	0.2768930073486256	0.2783266969884767	0.780761584205091	1.0	1.0	33	Q86YQ8,Q9H0H5,Q86Y07,Q13017	4
Metabolism of water soluble vitamins and cofactors	0.2662727200613937	0.2728755378048793	0.7849488911593387	1.0	1.0	41	P00374,Q9NRN7,P41440,Q969G6,Q9H2D1,P43490	6
Recycling pathway of l1	0.295719143037503	0.2722481469927533	0.7854312234636289	1.0	1.0	23	P35241,P51812,Q15418,P15311	4
Regulation of bach1 activity	0.4449633776531129	0.2713892554634668	0.7860916649658667	1.0	1.0	4	Q9BX63	1
Protein ubiquitination	0.2888635955590825	0.2698435227872944	0.7872806380286073	1.0	1.0	27	P49427,P61088,Q149N8,O75150,P60604,Q14527,P50542,Q16763	8
Cargo concentration in the er	0.2988230922482925	0.2635255313892449	0.7921455475851262	1.0	1.0	18	Q9Y6B6,Q8NI22,O95486,O14653,Q96PC5	5
Regulation of tp53 activity through phosphorylation	0.2655862076362112	0.262372874459345	0.7930339833817202	1.0	1.0	38	Q9UQ84	1
Gastrin creb signalling pathway via pkc and mapk	0.3818855892327867	0.2596733928692135	0.7951157181663522	1.0	1.0	7	P51812	1
Signal transduction by l1	0.3413909341398625	0.2594798162930366	0.7952650531232508	1.0	1.0	10	P67870,O14786	2
Cytosolic sensors of pathogen associated dna	0.2947765944138803	0.2552655352182635	0.7985180172596169	1.0	1.0	21	Q9UHD2,P19474,P49959,O15111	4
Pcp ce pathway	0.2572639660511155	0.2504169950739217	0.8022648880519505	1.0	1.0	53	P28070,P28074,P49721,Q99436,P28072	5
Negative regulation of mapk pathway	0.3009749373304845	0.2440571048363435	0.8071865934918103	1.0	1.0	16	P30154,Q13362	2
Tie2 signaling	0.4187515993701045	0.2435659898713662	0.8075669712454758	1.0	1.0	5	O00459,P62993	2
Condensation of prophase chromosomes	0.3249399615090104	0.2412616734815341	0.809352313724093	1.0	1.0	11	P53350,P14635,P06493,Q9NTJ3	4
Global genome nucleotide excision repair gg ner	0.2567690324252549	0.2377401488372476	0.8120826420025093	1.0	1.0	47	Q9NR33,Q9H9Q2,P41440,P61088,P54727,P41208,Q9UGN5,Q99627,Q9H981	9
Wax and plasmalogen biosynthesis	0.415944296849433	0.2365599187737971	0.8129982178334754	1.0	1.0	5	O00116	1
Dna double strand break repair	0.2588953620529808	0.2339886147434837	0.8149938174639477	1.0	1.0	63	Q9NR33,Q9UQ84,P41440,P61088,Q04323,Q9UGN5	6
Pcna dependent long patch base excision repair	0.2914166515443228	0.2320055450577048	0.8165337069680769	1.0	1.0	19	P41440	1
Resolution of sister chromatid cohesion	0.258712521760938	0.229959594328321	0.8181231673787859	1.0	1.0	69	P14635,Q96FJ2,Q13362,Q9BZD4,Q9Y6G9,O43683,Q8NBT2,P30154,P53350,Q8WYP5,Q9BVA1,Q7Z460,Q13409,P06493,Q71F23,Q9Y6D9,P49454,Q9Y266,O14777	19
Sensory processing of sound	0.2913148318906986	0.2293254461284879	0.8186159772627362	1.0	1.0	18	P35241,P23634,P35579,P52907,Q01082,P15311,Q13813,Q12792	8
Activation of the ap 1 family of transcription factors	0.42221015476516	0.2247420555171675	0.822179945821012	1.0	1.0	3	P27361,Q16539	2
Synthesis secretion and deacylation of ghrelin	0.4247922969203283	0.2224555924938906	0.8239592392145993	1.0	1.0	4	P67812	1
Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip	0.4247922969203283	0.2224555924938906	0.8239592392145993	1.0	1.0	4	P67812	1
Sema4d induced cell migration and growth cone collapse	0.3660465713429023	0.2150893094918259	0.8296976886424685	1.0	1.0	7	Q7Z406,P35580,O75116	3
Formation of rna pol ii elongation complex	0.2640070078580296	0.1918625733755266	0.8478498548596305	1.0	1.0	32	P35269,P55199,P13984,P50750,Q14241	5
Cell cycle mitotic	0.2510332860189348	0.1917564505100351	0.8479329852824473	1.0	1.0	279	Q8IXJ6,P14635,P33991,Q9NR33,P25787,P49642,Q86Y07,Q01105,Q96FJ2,Q13362,P28074,Q9BZD4,O75330,Q9Y6G9,Q9UQN3,O43683,Q15154,Q14566,Q9UJX2,O75935,Q16763,Q8N1F7,Q8NBT2,Q9Y6X3,P31350,P00374,P41440,Q7Z4H7,Q13561,P30307,P20618,Q14203,P50402,P30154,P04818,P53350,P42771,P62191,Q00534,O95684,P60900,Q8WYP5,P28070,Q9BVA1,Q9NTJ3,Q7Z460,Q96CS2,Q13409,P49721,Q9Y2S7,P06493,Q71F23,P11802,P49841,P67870,Q9Y6D9,O43805,P12270,Q6KC79,O15078,Q96RT8,Q5TKA1,Q9BRX5,O15504,O00311,P41208,Q9H8Y8,Q9Y266,Q99436,P28072,O14777,O43242,Q99640	73
Uptake and actions of bacterial toxins	0.339981792888225	0.1905654463745906	0.8488660638229444	1.0	1.0	8	P07900,Q16881,Q02750	3
G protein activation	0.4054439966547449	0.187819260156657	0.8510183370326034	1.0	1.0	3	P29992	1
Shc1 events in erbb4 signaling	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Activated ntrk2 signals through ras	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Activated ntrk3 signals through ras	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Shc mediated cascade fgfr4	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Shc mediated cascade fgfr3	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Shc mediated cascade fgfr1	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Shc related events triggered by igf1r	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Shc1 events in egfr signaling	0.4047685803944494	0.1864143381496771	0.852119849284291	1.0	1.0	3	P62993	1
Advanced glycosylation endproduct receptor signaling	0.3379439195630144	0.1851046151558396	0.8531469817918449	1.0	1.0	8	P52907	1
Josephin domain dubs	0.4027401399957133	0.1822339129906782	0.8553991598480957	1.0	1.0	3	P54727	1
Beta catenin independent wnt signaling	0.2509387439972347	0.1816057447062382	0.8558921401998616	1.0	1.0	60	P28070,P28074,P49721,Q9HCE1,Q99436,O14641,P28072	7
Mecp2 regulates transcription of neuronal ligands	0.401574803149621	0.1798587149733243	0.8572634872503591	1.0	1.0	3	Q13547,P51608	2
Dna replication pre initiation	0.2509847174262885	0.1737259961349199	0.8620808062168441	1.0	1.0	64	P33991,Q9NR33,P25787,P49642,P28070,O00311,P20618,P28074,P49721,Q99436,P62191,P28072,Q14566,O43242	14
E2f enabled inhibition of pre replication complex formation	0.388239911202223	0.1732672725126365	0.8624413473304899	1.0	1.0	5	P06493	1
Interleukin 35 signalling	0.3980450719522318	0.1727825634674155	0.8628223432369604	1.0	1.0	3	P42224,P40763	2
Interleukin 27 signaling	0.3980450719522318	0.1727825634674155	0.8628223432369604	1.0	1.0	3	P42224,P40763	2
Intracellular signaling by second messengers	0.240049966036584	0.1714891347530106	0.8638391731049286	1.0	1.0	100	O15111,Q15910,Q13362,P28074,P10644,P20618,P30154,P42345,P62191,P49840,P60900,P52292,P28070,Q9HC52,Q8TBX8,Q9NWH9,P49721,P49841,P67870,Q13555,O43865,O00459,P19174,Q9HCE1,Q99436,P62993,P28072,P25787,O43242	29
Srp dependent cotranslational protein targeting to membrane	0.2419853339873712	0.1711959146099692	0.8640697197442679	1.0	1.0	93	P18077,P61513,P62899,P67812,P62861,P46777,P42766,P62829,P35268,P46778,Q9Y3U8,P49458,P62266,P23396,P39023,P47914,P46779,P62917,P62913,P62424,Q15629,P62753,P84098,P60059,P62851,P50914,P61254,Q9BY50,P62847,P46782,P40429,P62750,P09132,P37108,P05387,P62841,P62263,P43307	38
Activation of nmda receptors and postsynaptic events	0.2711042920096191	0.1680991136819514	0.8665053066089565	1.0	1.0	25	P52292,Q13555,Q9BVA1,P51812,P54646,Q15418,P07196	7
Downstream signaling of activated fgfr2	0.3850655658964184	0.1667143279080744	0.8675948312765853	1.0	1.0	5	P19174,P62993	2
Downstream signaling of activated fgfr1	0.3850655658964184	0.1667143279080744	0.8675948312765853	1.0	1.0	5	P19174,P62993	2
Downstream signaling of activated fgfr3	0.3850655658964184	0.1667143279080744	0.8675948312765853	1.0	1.0	5	P19174,P62993	2
Downstream signaling of activated fgfr4	0.3850655658964184	0.1667143279080744	0.8675948312765853	1.0	1.0	5	P19174,P62993	2
Signaling by moderate kinase activity braf mutants	0.2812622458887677	0.165081621950238	0.8688797381009685	1.0	1.0	16	Q13555,P31946,P30086,P18206,P46940,Q02750	6
Signaling by braf and raf1 fusions	0.267508580132109	0.157399971034987	0.8749296362823498	1.0	1.0	26	Q13555,P31946,P51114,O15164,P30086,P18206,P46940,Q9NRY5	8
Er to golgi anterograde transport	0.2449460926709896	0.1542623440502604	0.87740288695984	1.0	1.0	83	Q96MW5,O43617,Q96FJ2,P52907,Q96PC5,Q9Y6G9,O75935,Q9Y6B6,Q13561,O95486,P61923,Q8NI22,Q8WTW3,Q9BVA1,Q12893,Q13409,Q92734,O15027,Q9UJW0,O14653,Q12907,O14579	22
Disorders of transmembrane transporters	0.2458471405691405	0.152761239778419	0.8785865650770526	1.0	1.0	81	P28074,P53985,O00400,Q8N1F7,Q9NP58,P08195,P20618,O75477,P62191,P28070,P49721,P12270,O94905,O15504,Q9UBV2,Q99436,P28072,P25787,O43242	19
Resolution of abasic sites ap sites	0.2628792150549592	0.1491591757320595	0.8814280326060289	1.0	1.0	28	P41440,Q9UGN5	2
Synthesis of dolichyl phosphate	0.3828400760249901	0.1443463805332134	0.8852269554020855	1.0	1.0	3	Q96E22,Q86YN1	2
Gap filling dna repair synthesis and ligation in gg ner	0.2702859798157385	0.1431628220211363	0.8861615910435754	1.0	1.0	19	P41440	1
Adp signalling through p2y purinoceptor 1	0.3829240611248093	0.138138659863208	0.8901308324948805	1.0	1.0	4	P29992	1
Rho gtpases activate formins	0.2463223203844941	0.1356201549024583	0.8921215713580752	1.0	1.0	70	O14777,Q96FJ2,Q13362,Q9BZD4,Q9Y6G9,O43683,Q8NBT2,P30154,P53350,O14641,Q8WYP5,Q9BVA1,Q7Z460,Q13409,Q71F23,Q9Y6D9,P49454,Q9Y266,P60953	19
Apc c cdc20 mediated degradation of cyclin b	0.286386005878632	0.1302458133985965	0.896371949406723	1.0	1.0	12	P14635,Q9H1A4,P06493,Q9UJX2,Q16763	5
Signaling by alk	0.3292790596730816	0.1281111006177751	0.89806105141643	1.0	1.0	7	P19174,O00459	2
Pentose phosphate pathway	0.2966862376198697	0.1266016317571317	0.8992557053797237	1.0	1.0	10	P49247	1
Insertion of tail anchored proteins into the endoplasmic reticulum membrane	0.2849171623748355	0.1261605078711936	0.8996048716781369	1.0	1.0	12	O43681,P50402,P46379	3
Initiation of nuclear envelope ne reformation	0.2656248124217164	0.1255520996357741	0.9000864817581642	1.0	1.0	18	Q8IXJ6,P06493,Q86Y07	3
Constitutive signaling by overexpressed erbb2	0.3375639227185827	0.1163774708529948	0.9073533897123665	1.0	1.0	6	P29353,Q16543,P62993	3
Negative regulation of nmda receptor mediated neuronal transmission	0.335319425574178	0.1124157750805864	0.9104937479041808	1.0	1.0	6	Q13555,P07196	2
Interaction between l1 and ankyrins	0.366351615905082	0.1114718957658224	0.9112421506123444	1.0	1.0	4	Q13813	1
Nervous system development	0.2381876927367158	0.1111290941326122	0.9115139778458264	1.0	1.0	230	P18077,P61513,P62899,P62861,P60953,P46777,Q15375,P42766,P28074,Q9BZI7,P11940,P35268,Q9NR77,Q9Y5S9,Q15418,Q9Y3U8,P35580,P29353,P23396,P20618,Q16850,P39023,O14786,P47914,P46779,P07948,P62917,P62913,P62424,P84098,P62191,Q15287,P59998,P52298,P60900,Q13813,Q02750,Q8N5V2,O00231,P62851,P50914,P28070,Q9BVA1,Q7Z460,Q9NWH9,P49721,P61254,P51812,P15311,P49841,P67870,P62847,O75116,P62750,P35241,Q7Z406,P35579,O00459,P19174,Q04637,Q99436,P62993,P62841,P62263,P49768,P28072,P25787,O43242,Q86SK9	69
Eph ephrin mediated repulsion of cells	0.2726861312407727	0.1092479915724716	0.9130057963036472	1.0	1.0	14	Q15375	1
Mrna splicing minor pathway	0.2433209829015081	0.1090481130719543	0.9131643291305358	1.0	1.0	34	P35269,P13984,Q16629,P67809	4
Insulin receptor signalling cascade	0.2975145260082468	0.1089879159280953	0.9132120749298438	1.0	1.0	9	P29353,O00459,P62993	3
Estrogen dependent nuclear events downstream of esr membrane signaling	0.3609451385116871	0.1035967341626819	0.9174893794799102	1.0	1.0	4	P27361,P28482,P31751	3
Ret signaling	0.3156697093047989	0.1020717509458531	0.9186997233572738	1.0	1.0	7	P19174,O00459,P62993	3
Cell extracellular matrix interactions	0.3139440065235176	0.0990103980796305	0.9211300141995776	1.0	1.0	7	Q13418,P12814,Q96AC1,P05556,Q15404,Q14315	6
Hdr through mmej alt nhej	0.2998922100765507	0.0981431396938622	0.9218186323312848	1.0	1.0	8	Q9UGN5	1
Rip mediated nfkb activation via zbp1	0.3443375025385627	0.0958070351729058	0.9236738298061316	1.0	1.0	5	O14920,O15111	2
Cell cycle	0.2454999488731769	0.095291733524464	0.9240831084677474	1.0	1.0	331	Q8IXJ6,P14635,P33991,Q9NR33,Q9UQ84,P49642,Q86Y07,Q9Y3B8,Q01105,Q96FJ2,Q13362,P28074,O75330,Q9Y6G9,Q9UQN3,O43683,Q15154,Q14566,O75935,Q8N1F7,Q8NBT2,Q9Y6X3,P00374,P41440,Q13561,Q7Z4H7,P30307,P20618,P30154,P04818,P42771,P53350,Q00534,O95684,P28070,P61088,Q9NTJ3,Q9UH99,Q7Z460,Q9UER7,P49721,Q96CS2,Q13409,P06493,P11802,Q9Y2S7,P49841,P67870,P49959,O14757,O43805,Q6KC79,O15078,Q96RT8,Q9BRX5,Q9NXR7,Q8NF91,Q5TKA1,P28072,Q9BX63,Q9H8Y8,Q9Y266,Q99436,P41208,O14777,O43242,Q99640	67
Negative feedback regulation of mapk pathway	0.3544269418794221	0.0946347655898952	0.9246049347978712	1.0	1.0	4	P27361,P28482,Q02750	3
Cohesin loading onto chromatin	0.2905189255873617	0.0944509084765135	0.92475097739936	1.0	1.0	9	Q6KC79	1
Mitochondrial iron sulfur cluster biogenesis	0.3500814774579103	0.0889800262101984	0.9290977839209428	1.0	1.0	4	P22570,Q9Y697,Q9H1K1	3
Mitotic spindle checkpoint	0.2385859519219164	0.0886141242833819	0.9293885826919812	1.0	1.0	65	Q8NFH4,Q96FJ2,Q13362,Q9BZD4,Q9Y6G9,O43683,Q9UJX2,Q16763,Q8NBT2,P30154,P53350,Q8WYP5,Q9H1A4,Q7Z460,Q13409,Q71F23,Q9Y6D9,P49454,Q9Y266,O14777	20
Processing of intronless pre mrnas	0.2574563164286201	0.0856679468011247	0.9317303831728876	1.0	1.0	16	P52298,Q8N684,Q86U42	3
Neddylation	0.2387542877663988	0.0843164712593081	0.9328048168636798	1.0	1.0	75	Q92905,P28074,Q8TBC4,Q8NEZ5,Q15345,P20618,P62191,Q99627,P60900,Q93034,Q9H9Q2,P28070,Q9Y5A7,P49721,Q99436,Q13564,P28072,P25787,O43242	19
Ras activation upon ca2 influx through nmda receptor	0.3171468054680196	0.0833789455072831	0.933550229260633	1.0	1.0	6	Q13555,P07196	2
Slc transporter disorders	0.2372120635653234	0.0822194973973609	0.9344721692553328	1.0	1.0	34	P53985	1
Fceri mediated mapk activation	0.269115646258495	0.0819439747359227	0.9346912652179702	1.0	1.0	11	P27361,P29353,P63000,P07948,P19174,P28482,Q13177,Q16512,P62993,O14733	10
Uptake and function of anthrax toxins	0.3329712112982146	0.0691388820004011	0.9448790717008156	1.0	1.0	4	P36507,Q8WUM4,Q02750	3
Irs mediated signalling	0.3063100927687533	0.0685931400466386	0.945313479456888	1.0	1.0	6	O00459,P62993	2
Costimulation by the cd28 family	0.2462498806784088	0.06403682822619	0.9489409022891055	1.0	1.0	17	O00459,Q13362,P07948,P30154,P62993,P60953	6
Rho gtpases activate pkns	0.2473417408152191	0.0632650546966015	0.9495554423091002	1.0	1.0	21	Q7Z406,P35580,P31946,Q9Y3B8,Q16513,P35579,P30307,Q04917	8
Signaling by fgfr3 fusions in cancer	0.2684581976112918	0.0546534250686039	0.9564145752766802	1.0	1.0	2	P62993	1
Grb2 events in erbb2 signaling	0.2684581976112918	0.0546534250686039	0.9564145752766802	1.0	1.0	2	P62993	1
Sos mediated signalling	0.2684581976112918	0.0546534250686039	0.9564145752766802	1.0	1.0	2	P62993	1
Signaling by erythropoietin	0.2930318841979109	0.0529495379067014	0.9577721141843824	1.0	1.0	6	P29353,P19174,P62993	3
G0 and early g1	0.2821692412431574	0.0520955142161277	0.9584525872515476	1.0	1.0	7	P06493,Q5TKA1	2
Gab1 signalosome	0.3068150963888292	0.0506375221080557	0.959614362846537	1.0	1.0	3	P41240,P62993	2
Signal regulatory protein family interactions	0.3068150963888272	0.0506375221080543	0.959614362846538	1.0	1.0	3	Q08722,P62993	2
Interleukin 20 family signaling	0.3068150963888243	0.0506375221080521	0.95961436284654	1.0	1.0	3	P42224,P40763	2
Generation of second messenger molecules	0.299565453557856	0.0407241980997458	0.9675157703008296	1.0	1.0	4	P19174,Q8N8S7,Q13177	3
Signalling to erks	0.2452811753455087	0.0387655520144398	0.9690773096889465	1.0	1.0	13	P29353,P11233,P31946,P62993	4
Signaling by flt3 fusion proteins	0.2688230497417834	0.0374751353756243	0.9701061653128564	1.0	1.0	7	Q92614,Q9UBW7,Q01082,Q15643,P62993,Q14789	6
Hsf1 activation	0.2387324488299552	0.0363836909549329	0.9709764183020776	1.0	1.0	16	Q15185,P62258,P25685,O75190,Q02790,P08238,Q00613,P07900	8
Pten regulation	0.2313449448670979	0.0358089342916052	0.971434709102812	1.0	1.0	72	P28070,P28074,P49721,Q9HCE1,Q99436,P28072	6
Hur elavl1 binds and stabilizes mrna	0.2633357237409939	0.0322668761185876	0.9742592244707542	1.0	1.0	7	P39687	1
Interleukin 4 and interleukin 13 signaling	0.2389355110645477	0.0271813794616557	0.9783150672561368	1.0	1.0	12	P09601,P08670,P04083,P42224	4
Vxpx cargo targeting to cilium	0.2424110888497861	0.0223338158619002	0.9821816744470993	1.0	1.0	9	Q9UPT5,Q8TAG9,Q8IYI6	3
Raf independent mapk1 3 activation	0.251155205218814	0.0222604055104229	0.982240232874836	1.0	1.0	7	P27361,P36507,P28482,P06493,Q06124,Q02750	6
Antigen presentation folding assembly and peptide loading of class i mhc	0.2306115329997041	0.019010529963899	0.9848327052319792	1.0	1.0	19	P10321,Q9Y6B6,Q6P179	3
Thromboxane signalling through tp receptor	0.2557563785442162	0.0188381450856926	0.984970223837634	1.0	1.0	5	P29992	1
Rna polymerase i transcription termination	0.2321244050460292	0.0171589332077813	0.9863098239144104	1.0	1.0	12	O15446	1
S phase	0.2232637660865168	0.0167400636821496	0.9866439854361332	1.0	1.0	99	P33991,Q9NR33,P49642,P28074,Q14566,Q9UJX2,Q16763,P41440,P20618,P62191,P60900,P28070,Q9H1A4,P49721,Q9Y2S7,P11802,P49841,Q5TKA1,Q9BRX5,Q99436,P28072,P25787,O43242	23
Sars cov 1 infection	0.2307911176794655	0.0159289759329606	0.9872910534809468	1.0	1.0	15	P49841,P49840	2
Purinergic signaling in leishmaniasis infection	0.2332044435730749	0.0117534891650513	0.9906222883733646	1.0	1.0	5	Q9Y2Z0,P09601	2
Copi dependent golgi to er retrograde traffic	0.2160821235541606	0.0114382789771872	0.990873772806192	1.0	1.0	53	P52732,O15260,Q9H0H5,Q9NS87,Q9NSK0,Q9BVA1,Q92538,P33176,Q9BW19,Q07866,Q9Y496,Q9P2W9,O14579,Q9H0B6,P61923,Q9H0U4,Q6NUQ1,P24390	18
Potential therapeutics for sars	0.2150549672885967	0.0109678297038197	0.9912491134596452	1.0	1.0	40	P62942	1
Incretin synthesis secretion and inactivation	0.2188567742709713	0.008847968786744	0.992940434422219	1.0	1.0	5	P67812	1
Synthesis secretion and inactivation of glucagon like peptide 1 glp 1	0.2188567742709713	0.008847968786744	0.992940434422219	1.0	1.0	5	P67812	1
Telomere c strand synthesis initiation	0.2089106221135542	0.0073928189658812	0.9941014376161426	1.0	1.0	5	Q14181,P49643,P49642,P09884	4
The nlrp3 inflammasome	0.2152229147746366	0.005722878626441	0.9954338284253336	1.0	1.0	6	Q9Y2Z0,P09601	2
Inflammasomes	0.2152229147746366	0.005722878626441	0.9954338284253336	1.0	1.0	6	Q9Y2Z0,P09601	2