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- interpro_active_site/advanced/idx2term.json +1 -0
- interpro_active_site/basic/idx2term.json +1 -0
- interpro_active_site/basic/plot_0.png +3 -0
- interpro_active_site/consensus.joblib +3 -0
- interpro_active_site/df_merge.tsv +1 -0
- interpro_active_site/metrics.json +7 -0
- interpro_active_site/paths.json +1 -0
- interpro_active_site/result.tsv +11 -0
- interpro_active_site/selections.json +1 -0
- interpro_binding_site/advanced/idx2term.json +1 -0
- interpro_binding_site/basic/idx2term.json +1 -0
- interpro_binding_site/basic/plot_0.png +3 -0
- interpro_binding_site/consensus.joblib +3 -0
- interpro_binding_site/df_merge.tsv +1 -0
- interpro_binding_site/metrics.json +7 -0
- interpro_binding_site/paths.json +1 -0
- interpro_binding_site/result.tsv +8 -0
- interpro_binding_site/selections.json +1 -0
- interpro_conserved_site/advanced/idx2term.json +1 -0
- interpro_conserved_site/basic/idx2term.json +1 -0
- interpro_conserved_site/basic/plot_0.png +3 -0
- interpro_conserved_site/basic/plot_1.png +3 -0
- interpro_conserved_site/basic/plot_2.png +3 -0
- interpro_conserved_site/basic/plot_3.png +3 -0
- interpro_conserved_site/consensus.joblib +3 -0
- interpro_conserved_site/df_merge.tsv +2 -0
- interpro_conserved_site/metrics.json +7 -0
- interpro_conserved_site/paths.json +1 -0
- interpro_conserved_site/result.tsv +38 -0
- interpro_conserved_site/selections.json +1 -0
- interpro_domain/advanced/idx2term.json +1 -0
- interpro_domain/basic/idx2term.json +1 -0
- interpro_domain/basic/plot_0.png +3 -0
- interpro_domain/basic/plot_1.png +3 -0
- interpro_domain/basic/plot_10.png +3 -0
- interpro_domain/basic/plot_11.png +3 -0
- interpro_domain/basic/plot_12.png +3 -0
- interpro_domain/basic/plot_13.png +3 -0
- interpro_domain/basic/plot_14.png +3 -0
- interpro_domain/basic/plot_15.png +3 -0
- interpro_domain/basic/plot_16.png +3 -0
- interpro_domain/basic/plot_17.png +3 -0
- interpro_domain/basic/plot_18.png +3 -0
- interpro_domain/basic/plot_19.png +3 -0
- interpro_domain/basic/plot_2.png +3 -0
- interpro_domain/basic/plot_20.png +3 -0
- interpro_domain/basic/plot_21.png +3 -0
- interpro_domain/basic/plot_22.png +3 -0
- interpro_domain/basic/plot_23.png +3 -0
- interpro_domain/basic/plot_3.png +3 -0
interpro_active_site/advanced/idx2term.json
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{}
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interpro_active_site/basic/idx2term.json
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{"0": "Serine/threonine-protein kinase, active site [IPR008271]"}
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interpro_active_site/basic/plot_0.png
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Git LFS Details
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interpro_active_site/consensus.joblib
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version https://git-lfs.github.com/spec/v1
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oid sha256:d6f48207e6f206c317f40fd0f58077b013fdb4abd2c9fc80fedb4a9ac5d82245
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interpro_active_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
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interpro_active_site/metrics.json
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{
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"type_of_task": "ranksum",
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"signature_size": 3205,
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"annotations_size": 55,
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"title": "Average number of proteins per term",
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"value": 2.8545454545454545
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}
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interpro_active_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C123/C123_val_log2fc"}
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interpro_active_site/result.tsv
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
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Protein-tyrosine phosphatase, active site [IPR016130] 0.6225612471649414 1.288940999983716 0.1974185988621366 0.9999944165835816 0.846784754543834 7 Q13614 1
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Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999] 0.7582760774515913 1.2666074112793082 0.2052957011092591 0.9999967543183004 0.846784754543834 3 P00390,P09622 2
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Thiolase, active site [IPR020610] 0.6149143762131454 1.1384024000801871 0.2549524923305397 0.9999999066491786 0.846784754543834 5 P42765,P24752 2
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Thiolase, acyl-enzyme intermediate active site [IPR020615] 0.600046473341412 1.0746729940013138 0.2825211587574201 0.9999999882645324 0.846784754543834 5 P42765,P24752 2
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Nucleoside diphosphate kinase, active site [IPR023005] 0.7093349984389596 0.4314416141547663 0.6661472971696327 1.0 0.9778723546743722 2 P15531 1
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ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440] 0.6934124258507607 0.3902226831160381 0.6963718898538709 1.0 0.9778723546743722 2 P53597 1
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L-lactate dehydrogenase, active site [IPR018177] 0.6390883546674941 0.2654798263074002 0.7906398487412669 1.0 0.9778723546743722 2 P00338 1
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Serine/threonine-protein kinase, active site [IPR008271] 0.3463416041944224 0.1528259718381991 0.8785355157533206 1.0 0.9778723546743722 53 Q99986,P28482,Q96SB4,Q7KZI7,P49137,Q9NYV4,Q8TD19,P78362,P19784,P54646,P49840 11
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Ubiquitin-activating enzyme E1, Cys active site [IPR033127] 0.3653966271080534 0.0956962727108037 0.92376180126092 1.0 0.9778723546743722 3 Q8TBC4,P22314 2
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Malate dehydrogenase, active site [IPR001252] 0.4308460817983052 0.0410914162573231 0.9672230176598648 1.0 0.9851345550239364 2 P40926 1
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interpro_active_site/selections.json
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{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["AAK1", "ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT1", "AKT3", "APEH", "ARAF", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKB", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CASP6", "CASP7", "CDC34", "CDK1", "CDK12", "CDK4", "CDK5", "CDK6", "CHEK1", "CHEK2", "CHUK", "CIT", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "CTSZ", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IKBKB", "IRAK1", "JAK1", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K4", "MAPK1", "MAPK3", "MAPK8", "MAPKAPK2", "MARK2", "MDH1", "MDH2", "MTMR14", "MTMR2", "MTMR6", "NEK9", "NME1", "NME3", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKCB", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "RIPK1", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TLK2", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1", "YES1"], "leading_proteins": ["ACAA2", "ACAT1", "CDK12", "CSNK2A2", "DLD", "GSK3A", "GSR", "LDHA", "MAPK1", "MAPKAPK2", "MARK2", "MDH2", "MTMR2", "NEK9", "NME1", "PRKAA2", "SRPK1", "SRPK2", "SUCLG1", "UBA1", "UBA3", "VRK1"]}
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interpro_binding_site/advanced/idx2term.json
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{}
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interpro_binding_site/basic/idx2term.json
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{"0": "Protein kinase, ATP binding site [IPR017441]"}
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interpro_binding_site/basic/plot_0.png
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Git LFS Details
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interpro_binding_site/consensus.joblib
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version https://git-lfs.github.com/spec/v1
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oid sha256:db1e4574e67ec389fb565d0ac12f7dcd0a51da4400eda2f577fc833b12d2271d
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size 71462
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interpro_binding_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
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interpro_binding_site/metrics.json
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{
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"type_of_task": "ranksum",
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"signature_size": 3205,
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"annotations_size": 33,
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"title": "Average number of proteins per term",
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"value": 4.454545454545454
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}
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interpro_binding_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C123/C123_val_log2fc"}
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interpro_binding_site/result.tsv
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
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Biotin-binding site [IPR001882] 0.988753514526711 2.5122502973461662 0.0119963969111105 0.3285225431155707 0.3958810980666479 4 P05165,Q96RQ3,P11498 3
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Hexokinase, binding site [IPR019807] 0.8726194192944103 0.9368915352409484 0.3488143538127153 0.9999992883621688 0.8222052625585432 2 P52789 1
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Peptidase M16, zinc-binding site [IPR001431] 0.5559982890215067 0.8880165664921124 0.3745318400893727 0.9999998117340366 0.8239700481966199 5 P22695,O75439,Q10713 3
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Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349] 0.7858257883234441 0.6529192445551224 0.5138083415887629 0.9999999999537994 0.9878117624183224 2 P50579 1
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Beta tubulin, autoregulation binding site [IPR013838] 0.4176272471820288 0.3642868199156907 0.7156438409039954 1.0 0.9878117624183224 5 Q13885 1
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Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917] 0.640337183890098 0.2680487213815175 0.7886618162146397 1.0 0.9878117624183224 2 O75600 1
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Protein kinase, ATP binding site [IPR017441] 0.3351728419488314 0.1380110998981139 0.8902316450476131 1.0 0.9878117624183224 49 Q99986,P28482,Q96SB4,Q7KZI7,P49137,P23458,Q9NYV4,P78362,P19784,P54646,P49840 11
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interpro_binding_site/selections.json
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{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Legume lectin, beta chain, Mn/Ca-binding site [IPR019825]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT1", "AKT3", "APEX1", "ARAF", "ARG2", "AURKB", "BPNT1", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK12", "CDK4", "CDK5", "CDK6", "CHEK1", "CHUK", "CIB1", "CIT", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQCB1", "IQGAP1", "IRAK1", "JAK1", "LETM1", "LRP2", "LYN", "MACF1", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPK3", "MAPKAPK2", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKAA2", "PRKACA", "PRKCB", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "TBK1", "TKT", "TLK2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1", "YES1"], "leading_proteins": ["CDK12", "CSNK2A2", "GCAT", "GSK3A", "HK2", "JAK1", "MAPK1", "MAPKAPK2", "MARK2", "MCCC1", "METAP2", "PC", "PCCA", "PMPCA", "PMPCB", "PRKAA2", "SRPK1", "SRPK2", "TUBB2A", "UQCRC2", "VRK1"]}
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{"0": "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "1": "WD40 repeat, conserved site [IPR019775]", "2": "Ubiquitin specific protease, conserved site [IPR018200]", "3": "Actinin-type actin-binding domain, conserved site [IPR001589]"}
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interpro_conserved_site/basic/plot_0.png
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interpro_conserved_site/basic/plot_1.png
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interpro_conserved_site/basic/plot_2.png
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interpro_conserved_site/basic/plot_3.png
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Git LFS Details
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interpro_conserved_site/consensus.joblib
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version https://git-lfs.github.com/spec/v1
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oid sha256:1b4852345eadf9e37626160882fef448a9492cedf2182a07d7694e59a601cc33
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size 81185
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interpro_conserved_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
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Proteasome beta-type subunit, conserved site [IPR016050] 2 8 1.973985328689356 0.0483834112012817 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 0.0479914252810258 0.004071454093033 0.00153832558414 0.0107435842434709
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interpro_conserved_site/metrics.json
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{
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"type_of_task": "ranksum",
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"signature_size": 3205,
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"annotations_size": 275,
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"title": "Average number of proteins per term",
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"value": 2.690909090909091
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}
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interpro_conserved_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C123/C123_val_log2fc"}
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interpro_conserved_site/result.tsv
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
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Proteasome beta-type subunit, conserved site [IPR016050] 0.781673391513017 1.973985328689356 0.0483834112012817 0.999998805871285 0.402406466010176 8 P49721,P28072 2
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Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892] 0.7543342612115874 1.855315838229184 0.0635511378008379 0.9999999856080966 0.402406466010176 8 P30414,P30405 2
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3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.8422860712054955 1.5894867031080198 0.1119505536990039 0.9999999999999932 0.5318384812338351 3 P40939,Q16836 2
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Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.6677380044343473 1.4913688602552564 0.1358646790299462 1.0 0.5725367669512175 7 P42356 1
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Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.690173221663961 1.3211611392896332 0.1864476407010666 1.0 0.6081350281526585 4 P48735,O75874 2
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Tr-type G domain, conserved site [IPR031157] 0.6239874625293709 1.3152107569256226 0.1884390809477372 1.0 0.6081350281526585 6 P13639,Q05639,P15170 3
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Dynein light chain, type 1/2, conserved site [IPR019763] 0.9619107087105836 1.2472084917986577 0.21232106003704 1.0 0.6301043598819344 2 P63167 1
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DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.6077729199561666 1.1017888372360147 0.2705534844576256 1.0 0.6688301287566893 14 Q7L2E3,Q8IX18,P54132,Q08211,P18074,Q9H2U1,Q9UNY4,Q14562 8
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Acyl-CoA-binding protein, ACBP, conserved site [IPR022408] 0.7014733481135738 1.0490005883604427 0.2941778476261454 1.0 0.7034687660625216 3 Q9H3P7 1
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Thiolase, conserved site [IPR020613] 0.5565251175438224 1.0131870668754763 0.3109708167966687 1.0 0.7192462338805533 6 P42765,P24752 2
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Fructose-bisphosphate aldolase class-I active site [IPR029768] 0.8635654074305328 0.9061926689542942 0.3648338826274475 1.0 0.7824109246797247 2 P04075 1
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Tubulin, conserved site [IPR017975] 0.523383027533957 0.8672389852286959 0.3858110797663538 1.0 0.7893257248974526 6 Q13885,P23258 2
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Guanylate kinase, conserved site [IPR020590] 0.5015031449908458 0.77282762059727 0.4396244046976585 1.0 0.8454315474954971 6 O14936,Q9NZW5 2
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Chaperonin TCP-1, conserved site [IPR002194] 0.506526554508643 0.7581502379447005 0.4483610474765349 1.0 0.8547290810030101 8 P17987,P50990,P40227,P48643 4
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Ribonuclease II/R, conserved site [IPR022966] 0.8145488604433324 0.743975090308081 0.4568915451179727 1.0 0.8547290810030101 2 Q9Y2L1 1
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Procollagen-lysine 5-dioxygenase, conserved site [IPR001006] 0.6080674220196017 0.7037340670262171 0.4815984006539442 1.0 0.8713128959199649 3 O00469 1
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Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842] 0.7958164221042738 0.6841929209354947 0.4938533518179826 1.0 0.8876449133983347 2 P60891 1
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Phosphofructokinase, conserved site [IPR015912] 0.558862855089125 0.5359834850868209 0.591969964313968 1.0 0.9748008394391688 3 P17858 1
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Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.5489687832215494 0.5040959523064206 0.614193951183732 1.0 0.9818875219139012 3 Q9BXS5 1
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Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628] 0.7336871682797342 0.4980437491259889 0.6184532066613171 1.0 0.9818875219139012 2 Q6UB35 1
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Aldo/keto reductase, conserved site [IPR018170] 0.7127692788011202 0.440581631909146 0.6595159028380966 1.0 1.0 2 P14550 1
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DNA-directed DNA polymerase, family B, conserved site [IPR017964] 0.7118326568841673 0.4380803682424339 0.6613280250369895 1.0 1.0 2 P09884 1
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WD40 repeat, conserved site [IPR019775] 0.4757434360014154 0.3958949689958854 0.6921825126533421 1.0 1.0 53 Q9NZJ0,Q9NV06,Q8TEQ6,O75530,Q9ULV4,Q9NWT1,Q9UFC0,Q9UMS4,Q14137,Q9BV38,Q16576,P53621,O43815,Q8WUA4,Q8TAF3,P43034,Q9GZL7,Q96DI7,Q05048,Q9BQA1,Q9BQ67,P61964,Q9Y5J1,Q13347,O43172,O75083,P63244 27
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ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847] 0.6934124258507607 0.3902226831160381 0.6963718898538709 1.0 1.0 2 P53597 1
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Ubiquitin specific protease, conserved site [IPR018200] 0.4194267906039216 0.3475575938074545 0.7281724581962383 1.0 1.0 14 Q96K76,P54578,Q9Y4E8,P45974,Q93008,Q14694,P40818,P51784 8
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Ribosomal protein S5, N-terminal, conserved site [IPR018192] 0.6753044021230052 0.3457934287919821 0.7294979639367838 1.0 1.0 2 P15880 1
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GTP1/OBG, conserved site [IPR006074] 0.6450202934748623 0.2778131533690375 0.7811557935761122 1.0 1.0 2 P55039 1
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Sterol reductase, conserved site [IPR018083] 0.6056821729628417 0.2023688524460091 0.8396283767645536 1.0 1.0 2 Q14739 1
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Ribosomal protein L3, conserved site [IPR019926] 0.6006868560724262 0.1938792802336139 0.8462704078374792 1.0 1.0 2 P39023 1
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Thiosulphate sulfurtransferase, conserved site [IPR001307] 0.5975647830159168 0.1887002314632972 0.8503277701657008 1.0 1.0 2 P25325 1
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RNA polymerase, beta subunit, conserved site [IPR007121] 0.4219539858155277 0.1781182458313993 0.8586301130553438 1.0 1.0 3 Q9NW08 1
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tRNA-dihydrouridine synthase, conserved site [IPR018517] 0.5629097720886604 0.1377770883483784 0.8904165924968419 1.0 1.0 2 Q9NX74 1
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Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866] 0.3910639375106853 0.1280070284303051 0.8981434109199156 1.0 1.0 3 P53396 1
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Serpin, conserved site [IPR023795] 0.5457383702778578 0.1169500424849138 0.9068996420350616 1.0 1.0 2 P50454 1
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Ubiquitin conserved site [IPR019954] 0.3823039522757978 0.1160477541403874 0.9076146951014336 1.0 1.0 3 P54578 1
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D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752] 0.514829847018413 0.0864436264603095 0.9311137677993552 1.0 1.0 2 Q13363 1
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Actinin-type actin-binding domain, conserved site [IPR001589] 0.2737263517863342 0.0687264945562563 0.9452073284547028 1.0 1.0 13 Q8WXH0,P21333,O75369,Q14651,Q14315 5
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interpro_conserved_site/selections.json
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{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AF4 interaction motif [IPR043639]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Deoxyribonuclease, TatD-related, conserved site [IPR018228]", "Di-trans-poly-cis-decaprenylcistransferase-like, conserved site [IPR018520]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Uncharacterised protein family UPF0029, Impact, conserved site [IPR020569]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFF4", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APAF1", "APEX1", "APP", "ARHGEF7", "ARIH2", "ATAD1", "ATAD2", "ATM", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BDH2", "BLM", "BOP1", "BPNT1", "BRD1", "BRD2", "BRD3", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHDDS", "DHFR", "DHRS11", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DIS3L2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DST", "DTL", "DTYMK", "DUS2", "DUS3L", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPDR1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP1", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK1", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HOXA10", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPACT", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MAPK8", "MARS", "MAT2A", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MKRN2", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NOTCH2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL2", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIK3C3", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "POLR3B", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RASAL2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "RELA", "RIDA", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STMN1", "STRN", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TATDN1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBG1", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBFD1", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACAA2", "ACAT1", "ACBD3", "ACLY", "AKR1A1", "ALDOA", "AP1M1", "BLM", "BOP1", "CASK", "CCT5", "CCT6A", "CCT8", "COPA", "CORO1C", "CSTF1", "CTBP1", "DCAF13", "DHX30", "DHX36", "DHX40", "DHX8", "DHX9", "DIS3", "DRG2", "DTL", "DUS2", "DYNLL1", "EED", "EEF1A2", "EEF2", "EIF3I", "ERCC2", "FLNA", "FLNB", "FLNC", "GEMIN5", "GRWD1", "GSPT1", "GTF3C2", "HADH", "HADHA", "IDH1", "IDH2", "LBR", "LRWD1", "MPP6", "MPST", "MTHFD1L", "NKTR", "PAFAH1B1", "PAK1IP1", "PFKL", "PI4KA", "PLOD2", "PLS1", "POLA1", "POLR3B", "PPIF", "PRPF19", "PRPF4", "PRPS1", "PSMB2", "PSMB6", "RACK1", "RBBP7", "RPL3", "RPS2", "SERPINH1", "SNRNP40", "STRN", "SUCLG1", "SYNE2", "TCP1", "TTF2", "TUBB2A", "TUBG1", "USP10", "USP11", "USP14", "USP15", "USP47", "USP5", "USP8", "USP9X", "UTP18", "WDR1", "WDR12", "WDR18", "WDR48", "WDR5", "WDR77"]}
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{"0": "Glutathione S-transferase, C-terminal [IPR004046]", "1": "Peptidase M16, C-terminal [IPR007863]", "2": "Peptidase M16, N-terminal [IPR011765]", "3": "Aminoacyl-tRNA synthetase, class II [IPR006195]", "4": "BRCT domain [IPR001357]", "5": "Domain of unknown function DUF1605 [IPR011709]", "6": "Helicase-associated domain [IPR007502]", "7": "GTP binding domain [IPR006073]", "8": "Actin-depolymerising factor homology domain [IPR002108]", "9": "Double-stranded RNA-binding domain [IPR014720]", "10": "Small GTP-binding protein domain [IPR005225]", "11": "Protein kinase domain [IPR000719]", "12": "Helicase, C-terminal [IPR001650]", "13": "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "14": "AP complex, mu/sigma subunit [IPR022775]", "15": "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "16": "Ubiquitin specific protease domain [IPR028889]", "17": "DEAD/DEAH box helicase domain [IPR011545]", "18": "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "19": "Pleckstrin homology domain [IPR001849]", "20": "Zinc finger C2H2-type [IPR013087]", "21": "Calponin homology domain [IPR001715]", "22": "Zinc finger, PHD-finger [IPR019787]", "23": "SANT domain [IPR017884]"}
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