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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:65faab5905b1cd96163ae29e6bf8536c7733c65d13abb7b7b0a8500ee7cc4fbc
+size 68710

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2887,
+    "annotations_size": 50,
+    "title": "Average number of proteins per term",
+    "value": 2.48
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C142/C142_val_log2fc"}

interpro_active_site/result.tsv

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+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Thiolase, active site [IPR020610]	0.7079078177856	1.3773162352176536	0.1684144978879096	0.9999010660244444	0.4130191669095821	5	Q9BWD1	1
+Histidine acid phosphatase active site [IPR033379]	0.8793760831888964	1.2689277384855742	0.2044668380418031	0.9999892126591712	0.4646973591859161	2	Q9NPH0	1
+Serine carboxypeptidase, serine active site [IPR018202]	0.8856412925173566	1.205166452050699	0.2281390505201743	0.9999976179357678	0.4959544576525529	3	Q9HB40	1
+Ribonucleotide reductase small subunit, acitve site [IPR030475]	0.7864818024263415	0.9065214336853272	0.3646599253936857	0.9999999998586446	0.6406424043348707	2	P31350	1
+ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]	0.2814558058925344	0.0263454044020797	0.9789818399895108	1.0	0.9789818399895108	2	P53597	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA/RNA non-specific endonuclease, active site [IPR018524]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "BUB1", "CAMK2G", "CAPN1", "CDK1", "CDK12", "CDK4", "CDK5", "CDK6", "CDK9", "CHUK", "CKB", "CKMT1A*", "CLK3", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "ENDOG", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K4", "MAPK1", "MAPKAPK2", "MDH1", "MDH2", "MTMR2", "NEK9", "NME1", "NME2", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPN9", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "RRM2B", "SCP2", "SCPEP1", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TAOK1", "TIGAR", "TOP1", "TPI1", "TPP2", "TRIO", "TXNRD1", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2S", "UMPS", "UNG", "VRK1"], "leading_proteins": ["ACAT2", "ACP6", "RRM2", "SCPEP1", "SUCLG1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:d952cb53ccb73eb9ffec5ad88e0d5bdafc747d69f15bbfe5ed1558c7f523b7c7
+size 66308

interpro_binding_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2887,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.258064516129032
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C142/C142_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M16, zinc-binding site [IPR001431]	0.6687618567908074	1.2143380279081877	0.2246186697695931	0.9996241837687152	0.4721430588395279	5	P22695	1
+EF-Hand 1, calcium-binding site [IPR018247]	0.3764419788704339	0.9244138831975496	0.3552708691701636	0.9999987677577497	0.6478468790750043	35	O43707,O43852,O75746,Q9BRK5,Q9BPX6,Q96AY3,Q9NWM8,Q14257	8
+2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]	0.3706657420249655	0.0244289966999224	0.9805104192017932	1.0	0.9805104192017932	3	P11182,P36957	2

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "BPNT1", "BUB1", "CALU", "CAMK2G", "CAPN1", "CDK1", "CDK12", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHUK", "CLK3", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPKAPK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK26", "STK4", "TAOK1", "TBK1", "TKT", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["ACTN4", "CALU", "DBT", "DLST", "FKBP10", "FKBP14", "MICU1", "RCN2", "SDF4", "SLC25A12", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Intermediate filament protein, conserved site [IPR018039]", "2": "DnaJ domain, conserved site [IPR018253]", "3": "Thioredoxin, conserved site [IPR017937]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:5a99cbab7a8e09383b1f37c3c24cf68236fd13e45d07ee15ca346103a67b538a
+size 88718

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	5	8	2.285103114911883	0.0223067822107978	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	1.0	0.0470522829573702	0.0930016660897952	0.001485709034831	2.312503759377148e-06
+Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]	2	5	2.118766935828481	0.0341101683349105	1.924757281553398	5.281553398058253	-0.9288267959189742	0.3228532003876247	1.35877896690138	0.6373104245544198	1.097198226180622	0.3047587347081354	0.0088936095868224	0.000467906411108	0.0018987369599165	0.0004573905935078	0.0034775277607499

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2887,
+    "annotations_size": 269,
+    "title": "Average number of proteins per term",
+    "value": 2.5353159851301115
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C142/C142_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,37 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.809519376814762	2.285103114911883	0.0223067822107978	0.9976852714055816	0.1582023895993741	8	P28072,P49721,P28074,Q99436,P28070	5
+Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]	0.8905326729126152	2.118766935828481	0.0341101683349105	0.9999117889869628	0.1835127056418187	5	P40939,Q13011	2
+Intermediate filament protein, conserved site [IPR018039]	0.7200959799221076	1.7346809093555975	0.0827973395461825	0.9999999999199858	0.3009795180800418	7	P20700,P07196,P02545,P08670,Q03252	5
+Haem oxygenase conserved site [IPR018207]	0.95597920277296	1.57434499741772	0.1154077122519874	0.9999999999999952	0.375935151486355	2	P09601	1
+Chromo domain, conserved site [IPR023779]	0.812748791289197	1.5613405848258757	0.1184434125634916	0.999999999999998	0.375935151486355	4	P83916,Q13185	2
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	0.6453280034576511	1.530250365170523	0.1259547690126985	0.9999999999999998	0.3764648096046211	8	O94788	1
+Guanylate kinase, conserved site [IPR020590]	0.6842653199029017	1.4451151415257737	0.1484255466032709	1.0	0.4202786530134723	6	O14936,Q8N3R9,Q9NZW5	3
+3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]	0.9351595006934812	1.383573332401354	0.1664891386007165	1.0	0.4478557828359276	3	P40939,Q16836	2
+Thiolase, conserved site [IPR020613]	0.6628225644386515	1.3514969042242655	0.1765363109223729	1.0	0.4610511421176537	6	Q9BWD1	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7343859253766516	1.2534146184365096	0.210054854121215	1.0	0.5036590170115601	4	Q86Y82,Q9P2W9	2
+DnaJ domain, conserved site [IPR018253]	0.5868396073293454	1.2507079926795164	0.2110410333326957	1.0	0.5036590170115601	8	P25685,P31689,Q8WXX5,Q96EY1,O60884,Q96KC8	6
+14-3-3 protein, conserved site [IPR023409]	0.5988664402009833	1.0713515655213346	0.2840113820896277	1.0	0.6040983009471654	6	Q04917,P62258,P63104	3
+Cadherin conserved site [IPR020894]	0.8114384748700196	1.0021613944368712	0.3162656499030181	1.0	0.6540224368725317	2	Q14126	1
+Mini-chromosome maintenance, conserved site [IPR018525]	0.568612692982781	0.9396230537404548	0.3474109467220643	1.0	0.6723276594837072	6	Q14566,P25205,P33993	3
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.7857885615251092	0.9038905720715324	0.3660534288437906	1.0	0.6744409065683541	2	P04066	1
+Profilin conserved site [IPR027310]	0.7185441941074351	0.6578284909693763	0.5106483446102057	1.0	0.763135581667474	2	P07737	1
+Histidine triad, conserved site [IPR019808]	0.702946273830154	0.6040645850363271	0.54580070388493	1.0	0.8022972095357714	2	Q9BX68	1
+Aldehyde dehydrogenase, glutamic acid active site [IPR029510]	0.4258225181950869	0.5039768302346695	0.6142776588935195	1.0	0.8423640634130718	8	O94788	1
+EGF-like calcium-binding, conserved site [IPR018097]	0.6610051993067555	0.4679832023448719	0.6397966021119903	1.0	0.8478092904833763	2	P01130	1
+Ribosomal S11, conserved site [IPR018102]	0.6398613518197568	0.4049391016110287	0.685522275435714	1.0	0.8508606494159167	2	P82912	1
+Ubiquitin specific protease, conserved site [IPR018200]	0.3710391846566323	0.3529079229198475	0.7241574708982812	1.0	0.8759107524681158	9	Q96K76	1
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.6217059639389737	0.3502824196625333	0.726126757622267	1.0	0.8759107524681158	3	Q9Y2T2,Q9BXS5	2
+D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]	0.4636101282512982	0.2880056281160376	0.7733424305084284	1.0	0.9026771245065456	4	P56545	1
+Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]	0.5948006932408918	0.285630165429206	0.7751613968810855	1.0	0.9026771245065456	2	P29692	1
+GTP1/OBG, conserved site [IPR006074]	0.5733102253032951	0.2368208508037114	0.8127957750234209	1.0	0.941119587366522	2	Q9Y295	1
+Annexin repeat, conserved site [IPR018252]	0.3736093032542423	0.2032603315196989	0.8389315591529998	1.0	0.9603088911155614	6	P08133	1
+Sterol reductase, conserved site [IPR018083]	0.5250703644839181	0.1513661259750602	0.8796869090985471	1.0	0.9850038753284276	3	O76062	1
+Ribosomal protein S2, conserved site [IPR018130]	0.5188908145580633	0.1387266474213003	0.8896661601040687	1.0	0.9850038753284276	2	P08865	1
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.5136915077989648	0.131288744148116	0.89554689558758	1.0	0.9850038753284276	2	P06737	1
+Heat shock protein Hsp90, conserved site [IPR019805]	0.4947988904299586	0.1091727224190092	0.9130654953232612	1.0	0.9903815251691824	3	P14625,P08238	2
+Vinculin, conserved site [IPR000633]	0.4523396880415906	0.0670951733847453	0.9465059363195514	1.0	1.0	2	P35221	1
+RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]	0.4343154246100542	0.0555178715485274	0.9557258924705918	1.0	1.0	2	Q9Y2P8	1
+Thioredoxin, conserved site [IPR017937]	0.2606882168925972	0.0541444244987507	0.9568200985034252	1.0	1.0	10	P07237,Q8NBS9,Q8IXB1,P30101,Q9H1E5,Q9H3N1,O95881,P13667,O43396	9
+S100/Calbindin-D9k, conserved site [IPR001751]	0.389601386481797	0.0373837842295202	0.97017900194328	1.0	1.0	2	P60903	1
+AT hook, DNA-binding motif [IPR017956]	0.3327556325823152	0.0283988013384707	0.97734408021035	1.0	1.0	2	Q6ZRS2	1
+ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]	0.2814558058925344	0.0263454044020797	0.9789818399895108	1.0	1.0	2	P53597	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AF4 interaction motif [IPR043639]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Helix-turn-helix motif [IPR000047]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFF4", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BCS1L", "BDH2", "BOP1", "BPNT1", "BRD2", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CDX2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CMPK1", "CNDP2", "COLEC12", "COPA", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DTL", "DTYMK", "DYNLL1", "DYNLL2", "ECH1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "ENO3", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "ING5", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPST", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLD1", "POLR1B", "POLR2B", "POLR2C", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RIDA", "RIOK2", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STMN1", "STOM", "STX10", "STX12", "STX18", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TM7SF2", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP13", "USP14", "USP34", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "WARS", "WARS2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ACAT2", "ALDH1A2", "ANXA6", "AP1M1", "AP3M1", "CASK", "CBX1", "CBX3", "CTBP2", "CTNNA1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC9", "DRG1", "DSG2", "ECH1", "EEF1D", "FUCA1", "HADH", "HADHA", "HINT2", "HMOX1", "HSP90AB1", "HSP90B1", "LDLR", "LMNA", "LMNB1", "LMNB2", "MCM3", "MCM6", "MCM7", "MPP5", "MPP6", "MRPS11", "NEFL", "P4HB", "PDIA3", "PDIA4", "PFN1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PYGL", "RCL1", "RPSA", "S100A10", "SRCAP", "STX12", "STX18", "SUCLG1", "TM7SF2", "TMX1", "TMX4", "TXNDC12", "TXNDC5", "TXNL1", "USP47", "VIM", "YWHAE", "YWHAH", "YWHAZ"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "K Homology domain, type 1 [IPR004088]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "K Homology domain, type 1 [IPR004088]", "1": "K Homology domain [IPR004087]", "2": "PDZ domain [IPR001478]", "3": "Intermediate filament, rod domain [IPR039008]", "4": "Pleckstrin homology domain [IPR001849]", "5": "RNA recognition motif domain [IPR000504]", "6": "DnaJ domain [IPR001623]", "7": "EF-hand domain [IPR002048]", "8": "Myb domain [IPR017930]", "9": "WW domain [IPR001202]", "10": "SANT domain [IPR017884]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:8279bbe0f9a1ec2948740d0c438cce11db6c5ee7c59a9a0ce9fa8d5d132468dc
+size 307244

interpro_domain/df_merge.tsv

@@ -0,0 +1,5 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+K Homology domain, type 1 [IPR004088]	11	22	2.317999376710533	0.0204493549326458	8.5	23.218446601941743	0.4539576731478794	0.576935027430011	4.690674491420825	1.6401661988255969	0.9187340965418598	0.3398774289684012	1.0	1.0	1.0	0.1988041978590851	0.0001777780576517
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	4	7	2.236765082665257	0.0253016977948992	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	1.0	0.0014481500629001	0.0001833288791406	5.522373670119844e-06	0.000160552482799
+Ubiquitin-like domain [IPR000626]	0	10	2.1498154786454724	0.0315698133321731	4.405339805825243	14.820388349514564	-0.0462692019740876	0.6086089683072633	2.7436193640206525	2.317466779992568	0.7856205542108695	0.2846932444846588	0.05227668272289	0.1835089509173778	0.3367676981326228	0.6437372861060551	0.8779339028138602
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	1	6	2.082728669070121	0.0372759626835015	2.941747572815534	6.145631067961165	0.9567723497044874	0.2732808833570771	1.8358630293390923	1.459204245106796	1.2102525517005158	0.2943240638910574	1.0	1.0	0.1933613304033528	0.0983610682747182	0.2914565107291916

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2887,
+    "annotations_size": 2444,
+    "title": "Average number of proteins per term",
+    "value": 2.122340425531915
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C142/C142_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,185 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+K Homology domain, type 1 [IPR004088]	0.5880670662764192	2.317999376710533	0.0204493549326458	1.0	0.1448644158127146	22	Q9Y6M1,Q8IWZ3,Q92945,Q9NQT5,Q96I24,Q9NZI8,Q96AE4,Q07666,P51114,Q13868,Q92667	11
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.8352558893414929	2.236765082665257	0.0253016977948992	1.0	0.1548371304666602	7	O95864,Q9UMX5,Q8WUJ1,O15173	4
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.8341043898442708	2.0827286690701214	0.0372759626835015	1.0	0.1768979665989858	6	Q9NQ11	1
+K Homology domain [IPR004087]	0.5354350930075525	1.9548561956433643	0.050600046098586	1.0	0.2057679079283598	22	Q9Y6M1,Q8IWZ3,Q92945,Q96I24,Q9NZI8,Q96AE4,Q07666,P51114,Q92667	9
+Major facilitator superfamily domain [IPR020846]	0.8376127689104765	1.9085327831363357	0.0563223901905467	1.0	0.2159572928874712	5	Q9H2V7,P53985,Q7L0J3,Q8NHS3	4
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8293749063024157	1.875421520094022	0.0607347568473384	1.0	0.2259295977700077	5	P09960,P55786,Q9UIQ6	3
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8293749063024157	1.875421520094022	0.0607347568473384	1.0	0.2259295977700077	5	P09960,P55786,Q9UIQ6	3
+PDZ domain [IPR001478]	0.5366406468708907	1.7723836821179413	0.0763308886498983	1.0	0.2601850653561388	19	Q14168,Q9NZW5,Q9HD26,Q9Y4G8,Q9UDY2,O14936,Q8N3R9	7
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.6890621386701855	1.7364354475876074	0.0824868690751103	1.0	0.2746565504353812	8	Q9UDY2,O14936,Q8N3R9,Q9NZW5	4
+Guanylate kinase-like domain [IPR008144]	0.6890621386701855	1.7364354475876074	0.0824868690751103	1.0	0.2746565504353812	8	Q9UDY2,O14936,Q8N3R9,Q9NZW5	4
+Intermediate filament, rod domain [IPR039008]	0.7200959799221076	1.7346809093555975	0.0827973395461825	1.0	0.2749411655582474	7	P20700,P07196,P02545,P08670,Q03252	5
+Cyclic nucleotide-binding domain [IPR000595]	0.7833629188318199	1.6887265807568177	0.0912718393225349	1.0	0.2883892826558904	5	Q9Y4G8,Q6P4Q7	2
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.9712305025996526	1.6351709362324454	0.1020132190036484	1.0	0.3068855695693017	2	P98179	1
+Pleckstrin homology domain [IPR001849]	0.4926209482203255	1.6204234945237546	0.105141336340927	1.0	0.3103447174121083	20	Q96JJ3,Q9BZF3,Q13464,Q01082,P19174,Q96P47,O75962,P31751,Q15057	9
+Peptidase M16, N-terminal [IPR011765]	0.6896146935431049	1.5978148099326228	0.1100841976582747	1.0	0.3187746197592694	7	Q5JRX3,P22695	2
+Peptidase M16, C-terminal [IPR007863]	0.6896146935431049	1.5978148099326228	0.1100841976582747	1.0	0.3187746197592694	7	Q5JRX3,P22695	2
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.6836767922145605	1.4425506894393634	0.1491470826399863	1.0	0.3841048155659922	6	Q8N4Q0	1
+SET domain [IPR001214]	0.7214861599983086	1.433712156383684	0.1516544216829491	1.0	0.3887491596613579	5	Q03164,Q9H7B4,Q9NRG4	3
+Far upstream element-binding protein, C-terminal [IPR015096]	0.9185441941074528	1.424914366167081	0.1541819563547024	1.0	0.3905840198602007	2	Q96AE4	1
+Rpn11/EIF3F, C-terminal [IPR024969]	0.7748847516374635	1.4128521817475383	0.1576991915372949	1.0	0.3943708151613952	4	O00303	1
+RNA recognition motif domain [IPR000504]	0.4163230488614419	1.4028905444082116	0.1606494809459624	1.0	0.3965932640726587	113	Q14103,P23588,P38159,Q92804,P52597,P35637,P31942,P31483,Q9Y6M1,P51991,P23246,P22626,P31943,O60506,Q9UN86,Q16629,Q15233,O14979,P98179,Q13151,Q07955,O75494,Q14011,Q99729,Q8WXF1,P55795,Q13247,Q96PK6,Q9BWF3,Q9UHX1,P07910,Q01130,O43390,P98175,P62995	35
+3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]	0.9351595006934812	1.383573332401354	0.1664891386007165	1.0	0.4060131330888732	3	P40939,Q16836	2
+3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]	0.9351595006934812	1.383573332401354	0.1664891386007165	1.0	0.4060131330888732	3	P40939,Q16836	2
+Chromo/chromo shadow domain [IPR000953]	0.6370515362600517	1.3589170092555984	0.1741728883027147	1.0	0.418473067116264	7	Q8TAQ2,P83916,Q13185	3
+Thiolase, C-terminal [IPR020617]	0.6628225644386515	1.3514969042242655	0.1765363109223729	1.0	0.4194262984352631	6	Q9BWD1	1
+Thiolase, N-terminal [IPR020616]	0.6628225644386515	1.3514969042242655	0.1765363109223729	1.0	0.4194262984352631	6	Q9BWD1	1
+L27 domain, C-terminal [IPR014775]	0.7565036420395501	1.3405220364957446	0.1800756849417721	1.0	0.4219027281173687	4	O14936,Q8N3R9,Q9NZW5	3
+L27 domain [IPR004172]	0.7565036420395501	1.3405220364957446	0.1800756849417721	1.0	0.4219027281173687	4	O14936,Q8N3R9,Q9NZW5	3
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.8949740034662054	1.3309492348076228	0.1832057153431496	1.0	0.4245761823972485	2	O43390	1
+G-protein gamma-like domain [IPR015898]	0.8831889081455815	1.284072416250216	0.1991166184431927	1.0	0.4497606427681728	2	Q9UBI6	1
+Zinc finger, CHHC-type [IPR012996]	0.9022191400832178	1.264787457533648	0.2059475287015644	1.0	0.4575779637696576	3	P55795,P31943	2
+Zinc finger, RanBP2-type [IPR001876]	0.5621729268171781	1.2606742382152154	0.2074262392846635	1.0	0.4600821226775287	9	P52756,P98175,P35637,Q92804	4
+MRH domain [IPR044865]	0.8989804242201379	1.2531279311899413	0.2101591525287252	1.0	0.4637555405208348	3	P11717	1
+Lamin tail domain [IPR001322]	0.895631067961165	1.2410755851576083	0.2145778278179997	1.0	0.4654571023428964	3	Q03252,P20700	2
+DnaJ domain [IPR001623]	0.535015794380875	1.2358613537795655	0.2165101043691524	1.0	0.4670578327939578	13	P25685,P31689,Q9NVH1,Q8WXX5,Q8IXB1,Q96EY1,O60884,Q96KC8,O75937	9
+NOPS [IPR012975]	0.8932038834951456	1.2323453585434083	0.2178201028726281	1.0	0.4683854263051072	3	Q8WXF1,P23246	2
+ERAP1-like C-terminal domain [IPR024571]	0.8900832177531208	1.2211257872115664	0.2220383974009641	1.0	0.4757971160106007	3	P55786,Q9UIQ6	2
+Ricin B, lectin domain [IPR000772]	0.7256330211585267	1.2189523706957084	0.2228622706598957	1.0	0.4765313993812644	4	Q86SF2,Q10471,Q10472	3
+Zinc finger, LIM-type [IPR001781]	0.6638248761866087	1.193776636976877	0.23256535293972	1.0	0.4878881738924255	5	Q14847,Q15942	2
+OBG-type guanine nucleotide-binding (G) domain [IPR031167]	0.661430418509699	1.183806253164319	0.2364897663441549	1.0	0.4940008452522348	5	Q9NTK5	1
+RNA recognition motif domain, eukaryote [IPR003954]	0.4964640169118945	1.0915942858794314	0.2750114688391551	1.0	0.531313693897846	15	P31483,Q9UHX1,P38159,Q14011	4
+BRICHOS domain [IPR007084]	0.8322357019063958	1.0830215739733562	0.2787988472307194	1.0	0.5319663197234571	2	Q9NQX7	1
+14-3-3 domain [IPR023410]	0.5988664402009833	1.0713515655213346	0.2840113820896277	1.0	0.5367744943234799	6	Q04917,P62258,P63104	3
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.844255559663063	1.057300866591863	0.290374297899393	1.0	0.5396603464174482	3	Q9ULX6	1
+Chromo shadow domain [IPR008251]	0.840846047156727	1.0452067768475783	0.2959274120111237	1.0	0.5471132943217049	3	P83916,Q13185	2
+Chromo domain subgroup [IPR017984]	0.840846047156727	1.0452067768475783	0.2959274120111237	1.0	0.5471132943217049	3	P83916,Q13185	2
+CARG-binding factor, N-terminal [IPR012956]	0.8225303292894306	1.0451738548383918	0.2959426248335899	1.0	0.5471132943217049	2	Q99729	1
+Cold shock domain [IPR011129]	0.6267746543753228	1.0398492570199906	0.2984099404372009	1.0	0.5495666616507817	5	P16989,P67809,Q6ZN17	3
+Cold-shock protein, DNA-binding [IPR002059]	0.6267746543753228	1.0398492570199906	0.2984099404372009	1.0	0.5495666616507817	5	P16989,P67809,Q6ZN17	3
+Rab-GTPase-TBC domain [IPR000195]	0.6790678139440522	1.0362971152202751	0.3000635515731069	1.0	0.5507018732730585	4	Q4KMP7	1
+Chaperone DnaJ, C-terminal [IPR002939]	0.6788067984738165	1.0352788583238086	0.3005387002661812	1.0	0.5507018732730585	4	P25685,O60884,Q96EY1	3
+Dynamin, N-terminal [IPR045063]	0.565297420288718	1.0305031430860452	0.3027738775621089	1.0	0.5519474652016456	7	O60313,O95140,O00429,Q9H223	4
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.565297420288718	1.0305031430860452	0.3027738775621089	1.0	0.5519474652016456	7	O60313,O95140,O00429,Q9H223	4
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.8355054425412332	1.0262967263802116	0.3047517398788317	1.0	0.5529422808194987	3	P10321	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.8355054425412332	1.0262967263802116	0.3047517398788317	1.0	0.5529422808194987	3	P10321	1
+MHC class I-like antigen recognition-like [IPR011161]	0.8355054425412332	1.0262967263802116	0.3047517398788317	1.0	0.5529422808194987	3	P10321	1
+Immunoglobulin C1-set [IPR003597]	0.8355054425412332	1.0262967263802116	0.3047517398788317	1.0	0.5529422808194987	3	P10321	1
+Cadherin-like [IPR002126]	0.8114384748700196	1.0021613944368712	0.3162656499030181	1.0	0.5633770031800118	2	Q14126	1
+Chromo domain [IPR023780]	0.6156037516810062	0.9936893709637248	0.3203741190105624	1.0	0.567965324180726	5	P83916,Q13185	2
+SWIB/MDM2 domain [IPR003121]	0.8069324090121148	0.9847694474688924	0.3247373312315722	1.0	0.5737574195710954	2	P41214	1
+EF-hand domain [IPR002048]	0.3774748660609485	0.9779318522266331	0.3281080301715362	1.0	0.5763585525044546	41	Q9UJS0,O43707,Q8IYU8,O43852,O75746,Q9BRK5,Q9BPX6,Q96AY3,Q9NWM8,Q14257	10
+N-acetylgalactosaminyltransferase [IPR045885]	0.8186546463245493	0.9669352001057316	0.3335764285131046	1.0	0.5827453833352594	3	Q86SF2,Q10472	2
+CBS domain [IPR000644]	0.5742943083982128	0.9642612632078906	0.3349149565559504	1.0	0.5838317787608721	6	P51797	1
+Myosin tail [IPR002928]	0.8013864818024266	0.9634345507631014	0.3353294943611424	1.0	0.5841377649455681	2	P35580	1
+MCM, AAA-lid domain [IPR041562]	0.568612692982781	0.9396230537404548	0.3474109467220643	1.0	0.5919393757862925	6	Q14566,P25205,P33993	3
+MCM OB domain [IPR033762]	0.568612692982781	0.9396230537404548	0.3474109467220643	1.0	0.5919393757862925	6	Q14566,P25205,P33993	3
+MCM N-terminal domain [IPR027925]	0.568612692982781	0.9396230537404548	0.3474109467220643	1.0	0.5919393757862925	6	Q14566,P25205,P33993	3
+MCM domain [IPR001208]	0.568612692982781	0.9396230537404548	0.3474109467220643	1.0	0.5919393757862925	6	Q14566,P25205,P33993	3
+Peptidase M41 [IPR000642]	0.7937608318890789	0.934235119435842	0.3501826236010381	1.0	0.5937549321128706	2	Q96TA2	1
+OCRE domain [IPR041591]	0.7920277296360514	0.927622102300502	0.3536036285919901	1.0	0.596828223949464	2	P98175	1
+Post-SET domain [IPR003616]	0.7902946273830043	0.9210180366227224	0.3570410103284445	1.0	0.5997307417475728	2	Q03164	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.7857885615251092	0.9038905720715324	0.3660534288437906	1.0	0.6036670580932688	2	P04066	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.6442157853919335	0.9012935168845144	0.3674322798920277	1.0	0.6043381040694148	4	P07196,P08670	2
+Extended PHD (ePHD) domain [IPR034732]	0.7850953206239035	0.9012612409650408	0.3674494364350043	1.0	0.6043381040694148	2	Q03164	1
+Fibronectin type III [IPR003961]	0.6429225301689854	0.8963292400822237	0.3700769468160811	1.0	0.6058057990746833	4	Q92859	1
+Syntaxin, N-terminal domain [IPR006011]	0.7795493934142108	0.880283037000176	0.3787059995968485	1.0	0.6113325383188227	2	Q86Y82	1
+LIS1 homology motif [IPR006594]	0.5543789456371623	0.8781819276120678	0.3798449979196301	1.0	0.6121540289560958	6	O95684	1
+Cold-shock (CSD) domain [IPR019844]	0.6171587137949042	0.7983421153966138	0.4246719843307898	1.0	0.6519461870002828	4	P16989,P67809	2
+Adenylate kinase, active site lid domain [IPR007862]	0.7438474870017351	0.7480061923954333	0.4544564224361083	1.0	0.6776641222903286	2	P27144	1
+MPN domain [IPR037518]	0.4338998393789007	0.7289841568776909	0.4660113537902641	1.0	0.6894259979802697	10	Q7L5N1,O00303	2
+Legume-like lectin [IPR005052]	0.7355285961871558	0.7179888958067624	0.4727641335614838	1.0	0.6951815491351583	2	P49257	1
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.4741764846604077	0.7171206834327465	0.4732996344501128	1.0	0.6951815491351583	8	Q7L5N1,O00303	2
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.7389402476050186	0.6954933097591574	0.4867462024471456	1.0	0.7085215716383705	3	P13674	1
+Class II aldolase/adducin N-terminal [IPR001303]	0.7164644714038026	0.650573695202881	0.5153217153307841	1.0	0.7352284134666879	2	Q9UEY8	1
+Aldehyde dehydrogenase domain [IPR015590]	0.4166213335347584	0.6423268721242611	0.520660969945669	1.0	0.7383460283872665	10	O94788	1
+Peptidase M28 [IPR007484]	0.7216551884677032	0.6395708730761009	0.5224516236301113	1.0	0.7397866559397405	3	Q7Z2K6	1
+ERM family, FERM domain C-lobe [IPR041789]	0.7066789281015602	0.5922597835392258	0.553676641771828	1.0	0.7632181119516906	3	P15311	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.5553243149497143	0.5734549423282536	0.5663366987054237	1.0	0.7718710227368665	4	P05023,P20020,P23634	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.5553243149497143	0.5734549423282536	0.5663366987054237	1.0	0.7718710227368665	4	P05023,P20020,P23634	3
+LEM-like domain [IPR013146]	0.6928942807625647	0.5702560353909609	0.5685040551133658	1.0	0.771902172609481	2	P42166	1
+CTP synthase, N-terminal [IPR017456]	0.6925476603119551	0.5691027094832464	0.5692864397303383	1.0	0.7721065808551314	2	Q9NRF8	1
+CTP synthase GATase domain [IPR033828]	0.6925476603119551	0.5691027094832464	0.5692864397303383	1.0	0.7721065808551314	2	Q9NRF8	1
+LEM domain [IPR003887]	0.4796292359047676	0.5673096215336497	0.570503841241579	1.0	0.7725949195295172	6	Q8NC56,Q86XL3	2
+Zinc finger, double-stranded RNA binding [IPR022755]	0.6890814558058928	0.5576167310938198	0.5771061290804713	1.0	0.7741069791858817	2	Q9UKJ3	1
+Ion transporter-like, CBS domain [IPR044751]	0.67487001733101	0.5114604613057022	0.609028667643799	1.0	0.7908958893312672	2	Q6P4Q7	1
+CNNM, transmembrane domain [IPR002550]	0.67487001733101	0.5114604613057022	0.609028667643799	1.0	0.7908958893312672	2	Q6P4Q7	1
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.6785714285714286	0.5067832054251848	0.6123069415610365	1.0	0.7922065458841573	3	O60884,Q96EY1	2
+EGF-like domain [IPR000742]	0.6763812055709308	0.5003238929424009	0.6168470329727529	1.0	0.7947148911889341	3	Q9P273	1
+U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]	0.5299719537903418	0.4874175026883562	0.6259624925229961	1.0	0.8003455381832436	4	P39687,Q15435	2
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.6641247833622003	0.4776248143686963	0.632917266070206	1.0	0.8009945448874181	2	P13674	1
+EGF-like calcium-binding domain [IPR001881]	0.6610051993067555	0.4679832023448719	0.6397966021119903	1.0	0.804505442343296	2	P01130	1
+Myb domain [IPR017930]	0.4494967025338532	0.4514817792547987	0.6516423543590977	1.0	0.8069060904255283	6	Q92922,Q99543,Q99459,Q8TAQ2,Q96KC8	5
+Modifier of rudimentary, Modr [IPR009851]	0.6499133448873455	0.4343968703289526	0.6640002700389314	1.0	0.8165776902450776	2	A5D8V6	1
+SUN coiled coil domain 2 [IPR040994]	0.6488734835355208	0.4313053728696756	0.6662463441780697	1.0	0.8169802034449098	2	O94901	1
+SAB domain [IPR007477]	0.6457538994800541	0.4220913744476405	0.6729583235659684	1.0	0.8169802034449098	2	P11171	1
+Band 4.1, C-terminal [IPR008379]	0.6457538994800541	0.4220913744476405	0.6729583235659684	1.0	0.8169802034449098	2	P11171	1
+rRNA-processing arch domain [IPR025696]	0.6415944540727896	0.4099492596794785	0.6818431691700255	1.0	0.819284515954544	2	Q15477	1
+ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]	0.6415944540727896	0.4099492596794785	0.6818431691700255	1.0	0.819284515954544	2	Q15477	1
+PABP, RNA recognition motif 2 [IPR045305]	0.6412478336221832	0.4089449019930137	0.6825800960355459	1.0	0.8193643196025905	2	P11940	1
+Band 7 domain [IPR001107]	0.4009594923586155	0.4026333904895054	0.6872179420345479	1.0	0.822135791133053	8	P27105,O75955	2
+AP complex, mu/sigma subunit [IPR022775]	0.5029541940219558	0.4011660490682379	0.688297875125258	1.0	0.822135791133053	4	Q9Y2T2,P53680	2
+SAP domain [IPR003034]	0.3755835234728382	0.3945789032482233	0.693153685575872	1.0	0.822135791133053	14	P82979,O75925	2
+Mu homology domain [IPR028565]	0.4998355748735507	0.3916236274186271	0.6953363274831479	1.0	0.8225566236054277	4	Q9Y2T2,Q9BXS5	2
+EH domain-containing protein, N-terminal [IPR031692]	0.6346620450606584	0.3900849879622356	0.696473703164695	1.0	0.8227627569855068	2	Q9H223	1
+Domain of unknown function DUF5600 [IPR040990]	0.6346620450606584	0.3900849879622356	0.696473703164695	1.0	0.8227627569855068	2	Q9H223	1
+Heat shock protein Hsp90, N-terminal [IPR020575]	0.4949705168227603	0.3769221173886986	0.7062314843134407	1.0	0.8278320132671698	4	Q12931,P14625,P08238	3
+Heat shock chaperonin-binding [IPR006636]	0.4939299340964342	0.373807411982662	0.7085476046609234	1.0	0.8278409757290067	4	Q9NRR5,P31948,Q9BSL1	3
+Nucleotidyl transferase domain [IPR005835]	0.6262650722862404	0.3618901795148464	0.71743409888683	1.0	0.8306015845455962	3	Q9NR50	1
+Longin domain [IPR010908]	0.6248266296809987	0.3582085504345074	0.7201872489187708	1.0	0.8306015845455962	3	O75396,O15498	2
+v-SNARE, coiled-coil homology domain [IPR042855]	0.6248266296809987	0.3582085504345074	0.7201872489187708	1.0	0.8306015845455962	3	O75396,O15498	2
+Cobalamin (vitamin B12)-binding domain [IPR006158]	0.6225303292894265	0.3564857478322487	0.7214768235640532	1.0	0.8309453998189626	2	P22033	1
+B-box, C-terminal [IPR003649]	0.6231627311279939	0.3539719877423765	0.723359876419339	1.0	0.8319489590441714	3	O15344	1
+Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]	0.6097053726169852	0.3226538483550798	0.7469574078278991	1.0	0.842827287502948	2	P20020	1
+Immunoglobulin I-set [IPR013098]	0.4716831857827955	0.3098751613526146	0.7566558920803632	1.0	0.847913850556749	4	Q92859	1
+Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]	0.343449166507338	0.3097486939530515	0.7567520701625181	1.0	0.847913850556749	10	Q96K76	1
+Ubiquitin specific protease domain [IPR028889]	0.343449166507338	0.3097486939530515	0.7567520701625181	1.0	0.847913850556749	10	Q96K76	1
+Dynamin, GTPase domain [IPR001401]	0.6042803239071837	0.3076088910213025	0.7583799540015879	1.0	0.847913850556749	3	O00429	1
+Immunoglobulin-like domain [IPR007110]	0.352788944917813	0.2940450756766245	0.7687234596477595	1.0	0.8520454128703511	14	O75962,Q92859,P10321,P04439	4
+Glycosyltransferase 2-like [IPR001173]	0.4249827564430498	0.2880292317681306	0.7733243626771948	1.0	0.855225746679909	5	Q86SF2,Q10472	2
+D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]	0.4636101282512982	0.2880056281160376	0.7733424305084284	1.0	0.855225746679909	4	P56545	1
+D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]	0.4636101282512982	0.2880056281160376	0.7733424305084284	1.0	0.855225746679909	4	P56545	1
+Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]	0.5948006932408918	0.285630165429206	0.7751613968810855	1.0	0.8564622305503495	2	P29692	1
+Elongation factor 1 beta central acidic region, eukaryote [IPR018940]	0.5948006932408918	0.285630165429206	0.7751613968810855	1.0	0.8564622305503495	2	P29692	1
+Major sperm protein (MSP) domain [IPR000535]	0.5833622183708811	0.2589627770189577	0.7956639606524369	1.0	0.8731938571327148	2	O95292	1
+BAT2, N-terminal [IPR009738]	0.5788561525129988	0.2488856851245614	0.80344920856697	1.0	0.8785815954083556	2	Q9Y520	1
+GTP binding protein, second domain [IPR031662]	0.5733102253032951	0.2368208508037114	0.8127957750234209	1.0	0.8872143252153821	2	Q9Y295	1
+CAP Gly-rich domain [IPR000938]	0.564298093587524	0.2180198346702885	0.8274136573013686	1.0	0.8999550415863573	2	Q14203	1
+Proteasomal ATPase OB C-terminal domain [IPR032501]	0.3959056210964524	0.2089668874801557	0.834474087904796	1.0	0.906021621874421	5	P43686,P62191,P62333,P17980	4
+DDE superfamily endonuclease domain [IPR004875]	0.5556325823223596	0.2008918749481115	0.8407831210560306	1.0	0.9106253407784508	2	Q7Z3K3	1
+HTH CenpB-type DNA-binding domain [IPR006600]	0.5556325823223596	0.2008918749481115	0.8407831210560306	1.0	0.9106253407784508	2	Q7Z3K3	1
+WW domain [IPR001202]	0.3287004864489284	0.2005240483597558	0.8410707520532084	1.0	0.9106253407784508	9	Q13576,Q8N1G2,O14776,O75400,P46939,Q13526,Q96J02,P46940	8
+Tim44-like domain [IPR007379]	0.5414211438474894	0.1748382631874337	0.8612067217035355	1.0	0.9280375784142156	2	O43615	1
+RecF/RecN/SMC, N-terminal [IPR003395]	0.3733518390006871	0.1560161618815678	0.8760202818809928	1.0	0.9382092764755242	5	Q14683,Q9NTJ3,Q9UQE7,Q96SB8	4
+Domain of unknown function DUF4749 [IPR031847]	0.5261698440208012	0.1497004844114421	0.8810009259822895	1.0	0.9406580441680714	2	O00151	1
+EH domain [IPR000261]	0.4006243496357933	0.1452056393480981	0.8845485135701623	1.0	0.9435804539440164	4	Q9H4M9,P42566,Q9H223	3
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.5201109570041611	0.1437829837664056	0.8856718402299111	1.0	0.9435804539440164	3	Q13308,P41240	2
+MoaB/Mog domain [IPR001453]	0.5216637781629114	0.1428296998552154	0.8864246804610612	1.0	0.9435804539440164	2	Q8NFF5	1
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.3493621128096448	0.1415328375576796	0.8874490205113255	1.0	0.9438317694210964	6	P13674	1
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.3493621128096448	0.1415328375576796	0.8874490205113255	1.0	0.9438317694210964	6	P13674	1
+GYF domain [IPR003169]	0.5150779896013906	0.1332397453075218	0.8940037788415813	1.0	0.948326925125358	2	Q6Y7W6	1
+U-box domain [IPR003613]	0.3602169906889274	0.1287780476343381	0.8975332763237434	1.0	0.950009236611186	5	P19474	1
+Ribosomal L28e/Mak16 [IPR029004]	0.5091854419410787	0.1251099072029484	0.9004365401116541	1.0	0.9526696554254904	2	Q9BXY0	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.5062413314840501	0.1239759086997406	0.9013343499557808	1.0	0.9531382116698436	3	Q1KMD3,Q00839	2
+FCP1 homology domain [IPR004274]	0.4987868284228797	0.1117844803262681	0.9109942932960304	1.0	0.9600266881398528	2	Q05D32	1
+Tudor domain [IPR002999]	0.334680849205294	0.1090319088413991	0.9131771816021824	1.0	0.9607425879620032	6	Q14739	1
+B-box-type zinc finger [IPR000315]	0.3458184640925539	0.1020431179454868	0.91872245051759	1.0	0.9638114747340998	5	O15344,P19474	2
+Myosin, N-terminal, SH3-like [IPR004009]	0.4883384063700108	0.1014188780154012	0.919217951249618	1.0	0.9638114747340998	3	P35580	1
+Rho GTPase-activating protein domain [IPR000198]	0.4859618717504292	0.0970973812398271	0.9226490605044588	1.0	0.9659568152763603	2	Q9H0H5	1
+ABC-transporter extension domain [IPR032781]	0.4814558058925536	0.0923809487618697	0.9263953753801112	1.0	0.9686799898438684	2	Q9NUQ8	1
+Putative RNA methylase domain [IPR000241]	0.4672443674176719	0.0789521355964671	0.937070694418318	1.0	0.9753836359277552	2	Q9BV44	1
+Target SNARE coiled-coil homology domain [IPR000727]	0.316294565830746	0.0736913702855453	0.9412559656340738	1.0	0.9779571252082956	6	Q86Y82,O15400	2
+Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]	0.4478336221837031	0.0639301773176924	0.9490258233955448	1.0	0.9803123890019914	2	Q5JTZ9	1
+Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]	0.4478336221837031	0.0639301773176924	0.9490258233955448	1.0	0.9803123890019914	2	Q5JTZ9	1
+Peptidase S9A, N-terminal domain [IPR023302]	0.4443674176776431	0.0616214385312713	0.9508643039054788	1.0	0.9809676482671972	2	P48147	1
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.4443674176776431	0.0616214385312713	0.9508643039054788	1.0	0.9809676482671972	2	P48147	1
+RNA 3'-terminal phosphate cyclase domain [IPR023797]	0.4343154246100542	0.0555178715485274	0.9557258924705918	1.0	0.983223385975635	2	Q9Y2P8	1
+RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]	0.4343154246100542	0.0555178715485274	0.9557258924705918	1.0	0.983223385975635	2	Q9Y2P8	1
+Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]	0.3133240804996469	0.0536624551456357	0.9572040961318428	1.0	0.9837707363104388	5	P55769,Q9NX24,P25398,P62424	4
+Peptidase S8/S53 domain [IPR000209]	0.4249566724436717	0.050579009639183	0.9596609892940612	1.0	0.985337189177359	2	O14773	1
+Clp ATPase, C-terminal [IPR019489]	0.3999999999999936	0.0404718819828313	0.9677169235955834	1.0	0.9912406375807232	2	O76031	1
+S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]	0.389601386481797	0.0373837842295202	0.97017900194328	1.0	0.9933462424588926	2	P60903	1
+Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]	0.3393414211438419	0.028944744732274	0.9769086594208628	1.0	0.994030584517808	2	Q9UKF6	1
+Ribosome receptor lysine/proline rich [IPR007794]	0.2928942807625527	0.0265702168713498	0.978802528363047	1.0	0.994030584517808	2	Q86UP2	1
+Zinc finger, PARP-type [IPR001510]	0.2863084922010316	0.0264302430609468	0.9789141720967236	1.0	0.994030584517808	2	P49916	1
+CoA-binding [IPR003781]	0.2814558058925344	0.0263454044020797	0.9789818399895108	1.0	0.994030584517808	2	P53597	1
+2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]	0.3706657420249655	0.0244289966999224	0.9805104192017932	1.0	0.9949719414984736	3	P11182,P36957	2
+SANT domain [IPR017884]	0.2625911774921806	0.0241622848771451	0.9807231616488636	1.0	0.9949719414984736	8	Q92922,O94776,Q99543,Q13330,Q8TAQ2,Q96KC8,O60264	7
+YTH domain [IPR007275]	0.2951786333680163	0.0235166097132319	0.9812381895135804	1.0	0.9950813838884608	4	Q9Y5A9,Q96MU7,Q9H6S0	3
+Exonuclease, RNase T/DNA polymerase III [IPR013520]	0.3500854290958557	0.0200211886073166	0.9840264698880103	1.0	0.9961456063386452	3	Q9GZR2	1
+E3 ligase, CCCH-type zinc finger [IPR041367]	0.3481276005547852	0.0196858594907186	0.9842939710870235	1.0	0.9961456063386452	3	Q86VM9,Q9UPT8	2
+Glutamine amidotransferase type 2 domain [IPR017932]	0.3377253814147021	0.0181134945121034	0.9855483126541916	1.0	0.9961456063386452	3	Q06203,P08243	2
+ATP-citrate lyase/succinyl-CoA ligase [IPR005811]	0.2816510579257659	0.0169426143264337	0.986482396321996	1.0	0.9964252319205622	4	Q9P2R7,Q96I99,P53597	3
+SCP2 sterol-binding domain [IPR003033]	0.3262829403606105	0.0167445971496722	0.9866403687593128	1.0	0.9964252319205622	3	P22307,P51659	2
+GTP binding domain [IPR006073]	0.2511902662165644	0.0114717266314959	0.9908470871900872	1.0	0.9990223931900052	12	Q8NC60,Q9NTK5	2