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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:fec60bff5341607a90be13e0d744852cf6cc3438b23490f76fed419c7c7514bd
+size 69366

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2888,
+    "annotations_size": 50,
+    "title": "Average number of proteins per term",
+    "value": 2.48
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C147/C147_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Histidine acid phosphatase active site [IPR033379]	0.9584199584199606	1.6809762495464735	0.0927675278929538	0.9923099473122264	0.2576875774804273	2	P11117	1
+Serine carboxypeptidase, serine active site [IPR018202]	0.974350086655112	1.5777859770013003	0.1146147864571767	0.9977269277690912	0.2728923487075636	3	Q9H3G5,Q9HB40	2
+Ribonucleotide reductase small subunit, acitve site [IPR030475]	0.8555093555093557	1.2599037833345228	0.2077040737703439	0.9999912022595484	0.3581104720178344	2	Q7LG56	1
+Tyrosine-protein kinase, active site [IPR008266]	0.5076230076229986	0.1404266182069705	0.8883229279336295	1.0	0.9450243914187548	2	P41240	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA/RNA non-specific endonuclease, active site [IPR018524]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "BUB1", "CAMK2G", "CAPN1", "CDK1", "CDK12", "CDK4", "CDK5", "CDK6", "CDK9", "CHUK", "CKB", "CKMT1A*", "CLK3", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "ENDOG", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K4", "MAPK1", "MAPKAPK2", "MDH1", "MDH2", "MTMR2", "NEK9", "NME1", "NME2", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPN9", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "RRM2B", "SCP2", "SCPEP1", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TAOK1", "TIGAR", "TOP1", "TPI1", "TPP2", "TRIO", "TXNRD1", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2S", "UMPS", "UNG", "VRK1"], "leading_proteins": ["ACP2", "CPVL", "CSK", "RRM2B", "SCPEP1"]}

interpro_binding_site/advanced/idx2term.json

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+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]", "1": "Beta tubulin, autoregulation binding site [IPR013838]", "2": "Protein kinase, ATP binding site [IPR017441]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:b2761502ef79afcf3ac373aaae3a16349bf46d085cc4916754f0de8b06d3d181
+size 67815

interpro_binding_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+EF-Hand 1, calcium-binding site [IPR018247]	9	35	2.947286992330677	0.0032057552705626	10.019417475728156	36.70631067961165	0.9532938980945532	0.3894555773109194	3.76037227687173	3.057484685571999	1.1082350706804749	0.3408841825650379	0.0004570607082828	0.0060275441501108	0.0009512079801521	0.0001029370613092	0.0013606605234105

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2888,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.258064516129032
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C147/C147_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-Hand 1, calcium-binding site [IPR018247]	0.6007383071577717	2.947286992330677	0.0032057552705626	0.0947444922076266	0.0451698952115191	35	O95302,Q96AY3,P80303,Q9Y680,P41208,Q9BRK5,Q02818,Q14257,O43852	9
+Peptidase M16, zinc-binding site [IPR001431]	0.7673437436821728	1.633552198798019	0.1023529118193611	0.9648217347071092	0.2644116888666829	5	O43847,P22695	2
+Beta tubulin, autoregulation binding site [IPR013838]	0.6263011797362896	1.2588781580309825	0.2080743441972949	0.9992768692987032	0.330573209465534	6	P68371,P04350,Q9BUF5,Q9BVA1,P07437	5
+Protein kinase, ATP binding site [IPR017441]	0.2597509857749586	0.0403468906667351	0.9678165708457253	1.0	1.0	38	P11802,P06493,Q7L7X3,O43683,O15111,Q00535,Q00534,P50750,Q9P289,P53350	10

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "BPNT1", "BUB1", "CALU", "CAMK2G", "CAPN1", "CDK1", "CDK12", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHUK", "CLK3", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPKAPK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK26", "STK4", "TAOK1", "TBK1", "TKT", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["BUB1", "CALU", "CDK1", "CDK4", "CDK5", "CDK6", "CDK9", "CETN2", "CHUK", "FKBP10", "FKBP7", "FKBP9", "NRDC", "NUCB1", "NUCB2", "PLK1", "RCN2", "SDF4", "STK26", "TAOK1", "TUBB", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "DnaJ domain, conserved site [IPR018253]", "1": "Tubulin, conserved site [IPR017975]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:7add8f99dff2d1682be90fe0c68390f3b735666887254f49ebc2b4bb7c6d8d59
+size 92085

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	4	8	2.103391832371192	0.0354315318288775	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	1.7763086736723583e-05	0.0461123069087121	0.0921025797166938	5.904010755783799e-05	5.279662360650864e-05

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2888,
+    "annotations_size": 269,
+    "title": "Average number of proteins per term",
+    "value": 2.5353159851301115
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C147/C147_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,37 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.7626287746815537	2.103391832371192	0.0354315318288775	0.9999389629793864	0.151287016856636	8	P49721,P28074,P28072,P28070	4
+Haem oxygenase conserved site [IPR018207]	0.9954954954954958	1.832085382056504	0.0669387008795177	0.9999999919492292	0.2165711723086022	2	P09601	1
+Tetraspanin, conserved site [IPR018503]	0.9812889812889832	1.7742867241388196	0.0760157353937067	0.999999999419542	0.2247058551748035	2	O60637	1
+Mini-chromosome maintenance, conserved site [IPR018525]	0.6784367160567265	1.499089276061835	0.1338504732644003	1.0	0.3214801545368187	6	P33991,P25205,Q14566,P33993	4
+DnaJ domain, conserved site [IPR018253]	0.6342175888141683	1.486211165379391	0.1372232751403024	1.0	0.3237987808135206	8	Q8WXX5,Q9NVH1,O60884,Q99543,Q96KC8,Q96EY1	6
+14-3-3 protein, conserved site [IPR023409]	0.6743025346262013	1.4801448662271108	0.1388345902728576	1.0	0.3242322930936653	6	P31946,P63104,Q04917	3
+Tubulin, conserved site [IPR017975]	0.6263011797362896	1.2588781580309825	0.2080743441972949	1.0	0.4407243983391523	6	P68371,P04350,Q9BUF5,Q9BVA1,P07437	5
+Guanylate kinase, conserved site [IPR020590]	0.6159799951304952	1.2110924043354816	0.2258599921560886	1.0	0.4527391245252193	6	O14936,Q8N3R9,Q92796,Q9NZW5	4
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	0.5669489705008035	1.151460075173349	0.2495430112105414	1.0	0.476078510749189	8	O94788,P30837	2
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7472260748959778	1.1184009501980343	0.2633957886994875	1.0	0.4920379663900149	4	Q86Y82,O60499,Q9P2W9	3
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.8163548163548155	1.1013391713357223	0.2707490688350917	1.0	0.4954523776642155	2	P13473	1
+ABC transporter-like, conserved site [IPR017871]	0.5397278719958116	1.0153854653215464	0.3099221187339371	1.0	0.5487595648507299	8	P08183	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.7900207900208094	0.9961768854211642	0.3191642081571468	1.0	0.5539043354469194	2	P04066	1
+Intermediate filament protein, conserved site [IPR018039]	0.5476268948035568	0.9916191043170246	0.3213833663461964	1.0	0.5541802919687618	7	P07197,P08670,P07196	3
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.811281129164309	0.9784424603879284	0.3278555365268298	1.0	0.5617397409281353	3	Q9BXS5	1
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.7563258232235672	0.783903348398804	0.433096824886056	1.0	0.6695577350249947	3	P26583,O15347	2
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.7210672210672177	0.7309139304711021	0.4648317265876107	1.0	0.6946651914003737	2	P06737	1
+Chaperonin TCP-1, conserved site [IPR002194]	0.4685288573412558	0.6652453738664769	0.5058935634299568	1.0	0.7238583434183956	8	P78371	1
+Sterol reductase, conserved site [IPR018083]	0.7160723756708766	0.6476114709005408	0.5172362761990466	1.0	0.7253994262457917	3	Q14739	1
+Actin, conserved site [IPR004001]	0.6874566874566832	0.609788306899208	0.5420020483449657	1.0	0.7400528138088087	2	P61163	1
+Aldehyde dehydrogenase, glutamic acid active site [IPR029510]	0.4533135536887056	0.5930179853845947	0.5531691158205723	1.0	0.7440124607786698	8	O94788,P30837	2
+Methylthiotransferase, conserved site [IPR020612]	0.6729036729036834	0.5596364170191451	0.5757274598300648	1.0	0.7491845712675244	2	Q96SZ6	1
+Dynamin, GTPase region, conserved site [IPR019762]	0.6465696465696469	0.4731080606617682	0.6361360862667236	1.0	0.7752556627250567	2	O00429	1
+Ubiquitin specific protease, conserved site [IPR018200]	0.4015601616840625	0.4115264608078142	0.6806865426396795	1.0	0.7995837553278332	9	Q96K76	1
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.5664640816681606	0.2302634775813736	0.8178870387778441	1.0	0.930458891578959	3	Q99536	1
+GTP1/OBG, conserved site [IPR006074]	0.5374220374220291	0.1914522867323648	0.8481712586994616	1.0	0.942647185247764	2	Q9Y295	1
+Oxysterol-binding protein, conserved site [IPR018494]	0.3902058432873672	0.1623794151120577	0.8710070800656882	1.0	0.9454720887978144	5	Q9BZF3	1
+Histidine triad, conserved site [IPR019808]	0.5211365211365123	0.1621140620734513	0.8712160327431981	1.0	0.9454720887978144	2	Q9BX68	1
+Chromo domain, conserved site [IPR023779]	0.4566574202496535	0.1615477576956412	0.8716620000812563	1.0	0.9454720887978144	4	Q13185,P83916,O14646	3
+Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]	0.5051975051974961	0.1367867810411851	0.8911993326252734	1.0	0.958930481904794	2	P29692	1
+Profilin conserved site [IPR027310]	0.4199584199584083	0.0531207425545248	0.9576357046156524	1.0	0.9960266530101471	2	P07737	1
+Cadherin conserved site [IPR020894]	0.3905058905058823	0.040324378406046	0.96783451842499	1.0	0.99936974975882	2	Q14126	1
+Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]	0.3832293832293776	0.0380488716066517	0.9696487163087436	1.0	0.99936974975882	2	P28482	1
+EGF-like calcium-binding, conserved site [IPR018097]	0.2678447678447603	0.0260929869696037	0.9791831707472975	1.0	1.0	2	P01130	1
+Heat shock protein Hsp90, conserved site [IPR019805]	0.3740034662044962	0.0151651889156251	0.9879003936882104	1.0	1.0	3	P07900,P08238	2
+3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]	0.356672443674168	0.0107177012665539	0.9914486753462896	1.0	1.0	3	Q16836,Q08426	2

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AF4 interaction motif [IPR043639]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Helix-turn-helix motif [IPR000047]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFF4", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BCS1L", "BDH2", "BOP1", "BPNT1", "BRD2", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CDX2", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CMPK1", "CNDP2", "COLEC12", "COPA", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DTL", "DTYMK", "DYNLL1", "DYNLL2", "ECH1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "ENO3", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "ING5", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPST", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLD1", "POLR1B", "POLR2B", "POLR2C", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RIDA", "RIOK2", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STMN1", "STOM", "STX10", "STX12", "STX18", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TM7SF2", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP13", "USP14", "USP34", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "WARS", "WARS2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ACTR1A", "ALDH1A2", "ALDH1B1", "AP1M1", "CASK", "CBX1", "CBX3", "CCT2", "CDK5RAP1", "CHD1", "DLG3", "DNAJA2", "DNAJA3", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DRG1", "DSG2", "EEF1D", "EHHADH", "FUCA1", "HADH", "HINT2", "HMGB2", "HMGB3", "HMOX1", "HSP90AA1", "HSP90AB1", "LAMP2", "LBR", "LDLR", "MAPK1", "MCM3", "MCM4", "MCM6", "MCM7", "MPP5", "MPP6", "NEFL", "NEFM", "OSBPL6", "PFN1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PYGL", "STX10", "STX12", "STX18", "TSPAN3", "TUBB", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "USP47", "VAT1", "VIM", "YWHAB", "YWHAH", "YWHAZ"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-hand domain [IPR002048]", "1": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-hand domain [IPR002048]", "1": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "2": "DnaJ domain [IPR001623]", "3": "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "4": "Tubulin/FtsZ, GTPase domain [IPR003008]", "5": "Proteasome component (PCI) domain [IPR000717]", "6": "SH3 domain [IPR001452]", "7": "PDZ domain [IPR001478]", "8": "K Homology domain, type 1 [IPR004088]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:d67f3cd8e00576c42a86c88a041a87866a44848bb3d9977336116b5db3ec8882
+size 315922

interpro_domain/df_merge.tsv

@@ -0,0 +1,6 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+EF-hand domain [IPR002048]	12	41	3.00551039101729	0.0026513553679665	12.385922330097088	43.512135922330096	1.0171858714399242	0.3947118087831401	4.608360476919044	4.087317384177653	1.201458704248258	0.3652478399429377	0.0018552982732521	0.0115064399742295	0.0027125023591425	0.0006169806372808	0.0009957254456233
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	7	11	2.638174597776388	0.0083353653784197	3.1262135922330097	10.111650485436892	0.9686720267359892	0.3700536707457866	1.7316562118191232	1.203619216216406	0.9607394322697528	0.3108814801432357	4.172433928650151e-08	2.7096103204179448e-05	8.963260011249366e-08	2.570679889114999e-07	2.888089353301009e-08
+SET domain [IPR001214]	3	5	2.065436772211829	0.038881692261222	2.3762135922330097	7.203883495145631	0.2385276779443848	0.4071855892228946	1.7492625999828462	2.5849047354362957	1.1957336270516616	0.3024983972109138	0.1554307406222585	0.1723099894081314	0.3209553841799009	0.0693227281157333	0.1254299298894934
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	2	5	1.9981397996848709	0.0457015059246113	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0002792632653159	0.0370595951599339	0.0743799864466655	0.000685273375659	0.0003209969829564
+Aminopeptidase N-like , N-terminal domain [IPR045357]	2	5	1.9981397996848709	0.0457015059246113	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0002792632653159	0.0370595951599339	0.0743799864466655	0.000685273375659	0.0003209969829564

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2888,
+    "annotations_size": 2445,
+    "title": "Average number of proteins per term",
+    "value": 2.121881390593047
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C147/C147_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,203 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-hand domain [IPR002048]	0.5586664234802088	3.00551039101729	0.0026513553679665	0.9984832310317064	0.1047951898335678	41	O95302,Q9BPX6,Q96AY3,P80303,Q9Y680,P41208,Q9BRK5,Q9NWM8,Q8NF37,Q02818,Q14257,O43852	12
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.7953280363912723	2.6381745977763877	0.0083353653784197	0.9999999987058096	0.1047951898335678	11	P62942,O95302,Q96AY3,Q02790,Q9Y680,P26885,Q13451	7
+SET domain [IPR001214]	0.8716921885912905	2.065436772211829	0.038881692261222	1.0	0.1697602456762285	5	Q03164,Q9NRG4,Q9H7B4	3
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8551584848661874	1.9981397996848709	0.0457015059246113	1.0	0.1881147844876677	5	Q9NZ08,P55786	2
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8551584848661874	1.9981397996848709	0.0457015059246113	1.0	0.1881147844876677	5	Q9NZ08,P55786	2
+Glutathione S-transferase, N-terminal [IPR004045]	0.7486581358751268	1.9493743703840405	0.0512507329689637	1.0	0.2017842868101713	7	P78417,Q9H7Z7	2
+Major facilitator superfamily domain [IPR020846]	0.8149610894919181	1.832678887255456	0.0668503388354151	1.0	0.2356425144904987	5	Q7L0J3,Q9H2V7	2
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.723240656330986	1.8317932583321932	0.0669822280453564	1.0	0.2356425144904987	7	O43169,O15173,Q9UMX5	3
+Peptidase M16, C-terminal [IPR007863]	0.715921904478895	1.7976852198727078	0.0722269049283788	1.0	0.2452705313192863	7	Q5JRX3,P22695,O43847	3
+Peptidase M16, N-terminal [IPR011765]	0.715921904478895	1.7976852198727078	0.0722269049283788	1.0	0.2452705313192863	7	Q5JRX3,P22695,O43847	3
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.7135288778869716	1.6589227487259592	0.0971313599617464	1.0	0.2987346369820409	6	Q9NQ11,Q9HD20,P05023	3
+IMD/I-BAR domain [IPR013606]	0.9404019404019424	1.6072793805497183	0.1079930954017904	1.0	0.3161172762457935	2	Q9UQB8	1
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.937629937629938	1.5959311347556375	0.1105041693299102	1.0	0.3193648865385704	2	P98179	1
+Band 7 domain [IPR001107]	0.6528207448214411	1.5777319747106344	0.1146271973360937	1.0	0.3254916168406409	8	O94905,P27105,O75477	3
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.6650377214262051	1.5576697150640488	0.1193115631621355	1.0	0.3287829077659328	7	Q9H223,O60313,O00429,Q9H4M9	4
+Dynamin, N-terminal [IPR045063]	0.6650377214262051	1.5576697150640488	0.1193115631621355	1.0	0.3287829077659328	7	Q9H223,O60313,O00429,Q9H4M9	4
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.9674176776429791	1.552219634023897	0.1206096797170377	1.0	0.3305625798067055	3	Q96G23,Q15629	2
+BRICHOS domain [IPR007084]	0.9206514206514268	1.5263849498610942	0.1269140235479025	1.0	0.3387845530565949	2	Q9NQX7	1
+Glutathione S-transferase, C-terminal-like [IPR010987]	0.5972899534057493	1.5243936066885155	0.1274104162207161	1.0	0.3397147957029999	10	P78417,Q9H7Z7	2
+ERAP1-like C-terminal domain [IPR024571]	0.9552859618717509	1.507438591947016	0.1316982730281815	1.0	0.3455614602564285	3	Q9NZ08,P55786	2
+MCM domain [IPR001208]	0.6784367160567265	1.499089276061835	0.1338504732644003	1.0	0.3468814071800905	6	P33991,P25205,Q14566,P33993	4
+MCM, AAA-lid domain [IPR041562]	0.6784367160567265	1.499089276061835	0.1338504732644003	1.0	0.3468814071800905	6	P33991,P25205,Q14566,P33993	4
+MCM OB domain [IPR033762]	0.6784367160567265	1.499089276061835	0.1338504732644003	1.0	0.3468814071800905	6	P33991,P25205,Q14566,P33993	4
+MCM N-terminal domain [IPR027925]	0.6784367160567265	1.499089276061835	0.1338504732644003	1.0	0.3468814071800905	6	P33991,P25205,Q14566,P33993	4
+14-3-3 domain [IPR023410]	0.6743025346262013	1.4801448662271108	0.1388345902728576	1.0	0.3546865370646438	6	P31946,P63104,Q04917	3
+DnaJ domain [IPR001623]	0.5453137473077557	1.474251709155544	0.1404138320228489	1.0	0.3557635433117779	13	Q8WXX5,Q9NVH1,O60884,O75937,Q99543,Q96KC8,Q96EY1	7
+Post-SET domain [IPR003616]	0.9060984060984056	1.466751510714566	0.1424436646873623	1.0	0.3590461444954649	2	Q03164	1
+Sterol-sensing domain [IPR000731]	0.9050589050589052	1.4624922614683566	0.1436063634119904	1.0	0.3608608001462657	2	O15118	1
+Metaxin, glutathione S-transferase domain [IPR033468]	0.9040194040194044	1.4582331280110956	0.1447762954139921	1.0	0.3619407385349804	2	Q13505	1
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.9040194040194044	1.4582331280110956	0.1447762954139921	1.0	0.3619407385349804	2	Q13505	1
+Amine oxidase [IPR002937]	0.8309349050947088	1.44493553977063	0.1484759925024981	1.0	0.3674728260266864	4	O60341	1
+FAD linked oxidase, N-terminal [IPR006094]	0.8842688842688984	1.3773525495516126	0.1684032756630848	1.0	0.3989786908878319	2	Q15392	1
+FAD-binding domain, PCMH-type [IPR016166]	0.8842688842688984	1.3773525495516126	0.1684032756630848	1.0	0.3989786908878319	2	Q15392	1
+Peptidase M28 [IPR007484]	0.9174174478351328	1.3674815238113602	0.1714744246246224	1.0	0.4028351304009873	3	P02786	1
+CBS domain [IPR000644]	0.6447118840104975	1.3439812165237417	0.1789544609846678	1.0	0.4081563965555157	6	P51797,Q8NE01,P51790	3
+Glutamine amidotransferase [IPR017926]	0.8011367141156875	1.3286658119755128	0.1839582489290241	1.0	0.4137791339755878	4	Q9NRF8,P49915	2
+Zinc finger, CHHC-type [IPR012996]	0.8970537261698436	1.2922463336833052	0.1962718505527378	1.0	0.4288966361781025	3	P52597,P31943	2
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.8969003245654354	1.2916799932871357	0.1964679887605214	1.0	0.4288966361781025	3	Q9UL46	1
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.8969003245654354	1.2916799932871357	0.1964679887605214	1.0	0.4288966361781025	3	Q9UL46	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.8617463617463621	1.2853252156668111	0.1986786621905463	1.0	0.4301588457850086	2	Q96AE4	1
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.6263011797362896	1.2588781580309825	0.2080743441972949	1.0	0.4427691658506407	6	P68371,P04350,Q9BUF5,Q9BVA1,P07437	5
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.6263011797362896	1.2588781580309825	0.2080743441972949	1.0	0.4427691658506407	6	P68371,P04350,Q9BUF5,Q9BVA1,P07437	5
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.5863374686808909	1.2483592130897665	0.2118995385973878	1.0	0.447791159784454	8	O14936,Q8N3R9,Q92796,Q9NZW5	4
+Guanylate kinase-like domain [IPR008144]	0.5863374686808909	1.2483592130897665	0.2118995385973878	1.0	0.447791159784454	8	O14936,Q8N3R9,Q92796,Q9NZW5	4
+RNA recognition motif domain, eukaryote [IPR003954]	0.4944839287508157	1.2418781698939707	0.2142815156017434	1.0	0.4504886548979043	15	Q01130,P38159,Q14011,Q9UHX1	4
+CTP synthase, N-terminal [IPR017456]	0.841302841302841	1.2021409895612718	0.2293089076704517	1.0	0.4711430918102979	2	Q9NRF8	1
+CTP synthase GATase domain [IPR033828]	0.841302841302841	1.2021409895612718	0.2293089076704517	1.0	0.4711430918102979	2	Q9NRF8	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.8312543312543308	1.1614291226177058	0.2454674313795106	1.0	0.491940876822052	2	O60506	1
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.8544194107452252	1.1353385836883298	0.25623348183526	1.0	0.5022404920319204	3	Q9Y282,Q96RQ1	2
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.8544194107452252	1.1353385836883298	0.25623348183526	1.0	0.5022404920319204	3	Q9Y282,Q96RQ1	2
+ABC transporter type 1, transmembrane domain [IPR011527]	0.7479969789665789	1.121398143730511	0.262118425942369	1.0	0.5098484896015053	4	P08183	1
+GOLD domain [IPR009038]	0.5932032416398546	1.1055924397849255	0.2689029635777071	1.0	0.5157076447747745	6	Q9Y3B3,Q15363	2
+Nucleotidyl transferase domain [IPR005835]	0.8415319254408633	1.088205016513886	0.276504610629618	1.0	0.5232614342023345	3	Q9NR50	1
+CARG-binding factor, N-terminal [IPR012956]	0.8097713097713085	1.0749111191630518	0.282414523298641	1.0	0.5266998546645135	2	Q99729	1
+Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]	0.8087318087318252	1.0707459547771945	0.2842836736402616	1.0	0.5289753288055097	2	P06865	1
+Glycoside hydrolase family 20, catalytic domain [IPR015883]	0.8087318087318252	1.0707459547771945	0.2842836736402616	1.0	0.5289753288055097	2	P06865	1
+L27 domain [IPR004172]	0.7291955617198338	1.0484555146242915	0.2944287877767264	1.0	0.5380256996368432	4	O14936,Q8N3R9,Q9NZW5	3
+L27 domain, C-terminal [IPR014775]	0.7291955617198338	1.0484555146242915	0.2944287877767264	1.0	0.5380256996368432	4	O14936,Q8N3R9,Q9NZW5	3
+Proteasome component (PCI) domain [IPR000717]	0.4501913470110069	1.043898038468997	0.2965325658289419	1.0	0.5393756252740882	17	Q9BT78,P60228,Q99627,O00231,P61201	5
+EB1, C-terminal [IPR004953]	0.7990297990297983	1.0319804712170195	0.3020812660599707	1.0	0.5437302090870928	2	Q15691	1
+ABC transporter-like, ATP-binding domain [IPR003439]	0.5397278719958116	1.0153854653215464	0.3099221187339371	1.0	0.5527057478515509	8	P08183	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.7900207900208094	0.9961768854211642	0.3191642081571468	1.0	0.565885778784789	2	P04066	1
+Intermediate filament, rod domain [IPR039008]	0.5476268948035568	0.9916191043170246	0.3213833663461964	1.0	0.568995170685337	7	P07197,P08670,P07196	3
+GINS subunit, domain A [IPR021151]	0.8080755346336032	0.9669001945354612	0.3335939293889864	1.0	0.5830144084031965	3	Q9Y248	1
+Mu homology domain [IPR028565]	0.7021363215449137	0.9442561409856804	0.345038772610037	1.0	0.5939564561906672	4	Q9BXS5	1
+PB1 domain [IPR000270]	0.7692307692307707	0.9143881110812864	0.3605129466845262	1.0	0.6062202217930289	2	Q13501	1
+CNNM, transmembrane domain [IPR002550]	0.7668052668052645	0.9049319446376398	0.3655014422970621	1.0	0.6100007006254723	2	Q8NE01	1
+Ion transporter-like, CBS domain [IPR044751]	0.7668052668052645	0.9049319446376398	0.3655014422970621	1.0	0.6100007006254723	2	Q8NE01	1
+SH3 domain [IPR001452]	0.3775880666396217	0.8997349058322174	0.3682613428181742	1.0	0.6125163150955347	31	Q9UNF0,P62993,Q9Y5X1,Q92796,Q9NZW5,Q8N3R9,Q9UQB8,Q9Y371	8
+Cold shock domain [IPR011129]	0.5881116397937125	0.8703499624874134	0.3841091827217242	1.0	0.627352673182776	5	P67809	1
+Cold-shock protein, DNA-binding [IPR002059]	0.5881116397937125	0.8703499624874134	0.3841091827217242	1.0	0.627352673182776	5	P67809	1
+Reticulon [IPR003388]	0.7799720799254108	0.8666494648423264	0.3861341022084401	1.0	0.6291234913342496	3	O95197	1
+Syntaxin, N-terminal domain [IPR006011]	0.746708246708244	0.8273877439363712	0.4080173250124497	1.0	0.6361198776328127	2	Q86Y82	1
+EH domain-containing protein, N-terminal [IPR031692]	0.7432432432432404	0.8141771155321187	0.4155434933827453	1.0	0.6406077183611679	2	Q9H223	1
+Domain of unknown function DUF5600 [IPR040990]	0.7432432432432404	0.8141771155321187	0.4155434933827453	1.0	0.6406077183611679	2	Q9H223	1
+Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]	0.7345807345807314	0.7813778510583267	0.4345802940879055	1.0	0.6534521426964881	2	O15228	1
+GPAT/DHAPAT, acyltransferase domain [IPR041728]	0.7345807345807314	0.7813778510583267	0.4345802940879055	1.0	0.6534521426964881	2	O15228	1
+Choline/carnitine acyltransferase domain [IPR039551]	0.7304227304227511	0.7657556339385675	0.4438217171647383	1.0	0.6604650629749149	2	P23786	1
+Ras-associating (RA) domain [IPR000159]	0.6440309413817383	0.7259852061498081	0.4678478397849144	1.0	0.6764565158333032	4	Q96L92,Q9Y4G8	2
+MD-2-related lipid-recognition domain [IPR003172]	0.7189882189882155	0.723232060348663	0.4695373249512968	1.0	0.6776970245017242	2	P61916	1
+MHC class I-like antigen recognition-like [IPR011161]	0.7379107056895089	0.7207450207802756	0.4710664074361248	1.0	0.6779030995770012	3	P10321	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.7379107056895089	0.7207450207802756	0.4710664074361248	1.0	0.6779030995770012	3	P10321	1
+Immunoglobulin C1-set [IPR003597]	0.7379107056895089	0.7207450207802756	0.4710664074361248	1.0	0.6779030995770012	3	P10321	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.7379107056895089	0.7207450207802756	0.4710664074361248	1.0	0.6779030995770012	3	P10321	1
+EH domain [IPR000261]	0.6401139179586165	0.7116598694025936	0.4766754237845672	1.0	0.6823603109796643	4	Q9H223,Q9H4M9	2
+Cold-shock (CSD) domain [IPR019844]	0.6331155172721672	0.6862214781143174	0.4925734557288641	1.0	0.6945456166419105	4	P67809	1
+Glycoside hydrolase family 38, N-terminal domain [IPR000602]	0.7058212058212198	0.6751310658473495	0.4995924979896577	1.0	0.7012076105537964	2	O00754	1
+Glycosyl hydrolase family 38, C-terminal [IPR011682]	0.7058212058212198	0.6751310658473495	0.4995924979896577	1.0	0.7012076105537964	2	O00754	1
+Glycoside hydrolase family 38, central domain [IPR015341]	0.7058212058212198	0.6751310658473495	0.4995924979896577	1.0	0.7012076105537964	2	O00754	1
+Aldehyde dehydrogenase domain [IPR015590]	0.4403984389050168	0.6723387408997422	0.5013680718518281	1.0	0.7024899344857993	10	O94788,P30837	2
+Intermediate filament head, DNA-binding domain [IPR006821]	0.627557837690414	0.6661708100562057	0.5053019282596964	1.0	0.7057546387194846	4	P07197,P08670	2
+Exportin-2, central domain [IPR013713]	0.7125168350202773	0.6359093754147754	0.5248354915470581	1.0	0.7185327334367458	3	O15397	1
+PDZ domain [IPR001478]	0.3758391148873704	0.6344796229200399	0.5257678610498415	1.0	0.7185327334367458	19	Q92796,Q9NZW5,Q9HD26,O00560,Q8N3R9,Q14168,O14936,Q9Y4G8	8
+OCRE domain [IPR041591]	0.6943866943866901	0.6341910252024361	0.5259561639300514	1.0	0.7185327334367458	2	P98175	1
+Legume-like lectin [IPR005052]	0.694040194040201	0.632963324189771	0.5267575935803539	1.0	0.7185327334367458	2	P49257	1
+VHS domain [IPR002014]	0.6923076923076881	0.6268366153142163	0.5307663394254143	1.0	0.7197580143622507	2	O14964	1
+MRH domain [IPR044865]	0.7041142507376645	0.608503976051084	0.5428532697066437	1.0	0.729272661776233	3	P20645	1
+Tim44-like domain [IPR007379]	0.6829521829521931	0.5941022454391208	0.552443729139227	1.0	0.7385046023758393	2	O43615	1
+NOPS [IPR012975]	0.6980935875216574	0.5890930700721586	0.5557988418931226	1.0	0.7401569544818544	3	P23246,Q8WXF1	2
+Cyclic nucleotide-binding domain [IPR000595]	0.5181739676516681	0.5854644377783473	0.5582354718496447	1.0	0.742063527918409	5	Q9Y4G8,P10644	2
+Class II aldolase/adducin N-terminal [IPR001303]	0.6781011781011735	0.5773707831227876	0.563689006731102	1.0	0.7457898384510522	2	Q9UEY8	1
+TRAM domain [IPR002792]	0.6729036729036834	0.5596364170191451	0.5757274598300648	1.0	0.7545558535937243	2	Q96SZ6	1
+Methylthiotransferase, N-terminal [IPR013848]	0.6729036729036834	0.5596364170191451	0.5757274598300648	1.0	0.7545558535937243	2	Q96SZ6	1
+Rho GTPase-activating protein domain [IPR000198]	0.6725571725571678	0.5584613720611459	0.5765293747060269	1.0	0.7546115209615823	2	Q9H0H5	1
+Chaperone DnaJ, C-terminal [IPR002939]	0.596389830027877	0.5565797711369029	0.5778145780134618	1.0	0.7548363175660944	4	O60884,Q96EY1	2
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.6580041580041527	0.5099663615989872	0.6100750285145513	1.0	0.7727700919207882	2	Q9NVI7	1
+Zinc finger, MYND-type [IPR002893]	0.6721465381527632	0.5078211379257097	0.6115787844035685	1.0	0.7727700919207882	3	Q9NRG4	1
+Rhodanese-like domain [IPR001763]	0.6552321552321505	0.5009266483616348	0.6164227471607409	1.0	0.774090198668727	2	Q99956	1
+STAT transcription factor, all-alpha domain [IPR013800]	0.654192654192649	0.497553702431292	0.6187986427126955	1.0	0.7746864728277216	2	P40763	1
+STAT transcription factor, protein interaction [IPR013799]	0.654192654192649	0.497553702431292	0.6187986427126955	1.0	0.7746864728277216	2	P40763	1
+STAT transcription factor, DNA-binding [IPR013801]	0.654192654192649	0.497553702431292	0.6187986427126955	1.0	0.7746864728277216	2	P40763	1
+CAP Gly-rich domain [IPR000938]	0.6476091476091423	0.476411102326267	0.6337815266149776	1.0	0.7778569405968953	2	Q14203	1
+Dynamin, GTPase domain [IPR001401]	0.6616817615776178	0.4762504456709757	0.63389596455361	1.0	0.7778569405968953	3	O60313	1
+AP complex, mu/sigma subunit [IPR022775]	0.5723085583437152	0.4758888318697823	0.6341535790551565	1.0	0.7778569405968953	4	P48444,Q9Y2T2	2
+Dynamin stalk domain [IPR000375]	0.6465696465696469	0.4731080606617682	0.6361360862667236	1.0	0.7778569405968953	2	O00429	1
+Dynamin GTPase effector [IPR003130]	0.6465696465696469	0.4731080606617682	0.6361360862667236	1.0	0.7778569405968953	2	O00429	1
+GTPase effector domain [IPR020850]	0.6465696465696469	0.4731080606617682	0.6361360862667236	1.0	0.7778569405968953	2	O00429	1
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.6575389948006956	0.4639615713546087	0.6426752782853677	1.0	0.7809846199839583	3	O60884,Q96EY1	2
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.6568457538994764	0.4619171425128229	0.6441407402719213	1.0	0.7815304399202453	3	Q9ULX6,Q5BKZ1	2
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.5679545367636998	0.4617343789841582	0.6442718140365855	1.0	0.7815304399202453	4	P05023	1
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.5679545367636998	0.4617343789841582	0.6442718140365855	1.0	0.7815304399202453	4	P05023	1
+Proteasomal ATPase OB C-terminal domain [IPR032501]	0.4845646895594974	0.4581169093367879	0.6468684511952549	1.0	0.7815304399202453	5	P62333,P62191,P17980,P62195	4
+ERM family, FERM domain C-lobe [IPR041789]	0.6454072790294595	0.4286956049243273	0.6681447595309273	1.0	0.7930164742976298	3	P15311,P35241	2
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.6445283619099116	0.4261838356725037	0.6699738950500189	1.0	0.7944161849647411	3	Q9BYT8	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.4391256336137351	0.4241244733554564	0.6714750381057912	1.0	0.7958102123939212	6	Q14914,Q99536	2
+LEM-like domain [IPR013146]	0.6219681219681181	0.3979265792599712	0.6906843070414033	1.0	0.8051565634033475	2	P42166	1
+Heat shock chaperonin-binding [IPR006636]	0.5471567267683773	0.3961974667394091	0.6919593599827252	1.0	0.8056383976941729	4	P31948,Q9BSL1,P54727	3
+Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]	0.3978406146195027	0.3945786374867777	0.6931538817419289	1.0	0.806261294414375	9	Q15067	1
+Arf GTPase activating protein [IPR001164]	0.4665591812753964	0.3937207798263575	0.6937871979358041	1.0	0.8066142172862772	5	Q96P47,Q15057	2
+Target SNARE coiled-coil homology domain [IPR000727]	0.4288759017970508	0.3840033141010214	0.700975991173175	1.0	0.812268387876025	6	O60499,Q86Y82	2
+K Homology domain, type 1 [IPR004088]	0.3115452068775415	0.3253064637188384	0.7449491393496139	1.0	0.8387680913426718	22	Q96PU8,Q07666,Q92945,Q96I24,P51114,Q96AE4	6
+Ku70/Ku80 beta-barrel domain [IPR006164]	0.5918225918225848	0.3144274371695502	0.7531964202104389	1.0	0.8455304166274211	2	P12956	1
+Ku70/Ku80 C-terminal arm [IPR005160]	0.5918225918225848	0.3144274371695502	0.7531964202104389	1.0	0.8455304166274211	2	P12956	1
+Ku70/Ku80, N-terminal alpha/beta [IPR005161]	0.5918225918225848	0.3144274371695502	0.7531964202104389	1.0	0.8455304166274211	2	P12956	1
+Stromalin conservative domain [IPR020839]	0.5738045738045732	0.2695571100844853	0.7875010003928018	1.0	0.87202896103279	2	Q8N3U4	1
+STAG [IPR013721]	0.5738045738045732	0.2695571100844853	0.7875010003928018	1.0	0.87202896103279	2	Q8N3U4	1
+U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]	0.5003157324730101	0.2632920703084636	0.7923254711160961	1.0	0.8765234493640948	4	Q92688,P39687	2
+Zinc finger, LIM-type [IPR001781]	0.4255983350676366	0.2601040431041906	0.7947835192921857	1.0	0.878104701612921	5	Q15942,O00151,Q14847,Q96HC4	4
+Pleckstrin homology domain [IPR001849]	0.3121243529959633	0.258050673792061	0.7963677991496863	1.0	0.879457664372621	20	Q9BZF3,Q96JJ3,Q96SU4,Q15057	4
+Myosin tail [IPR002928]	0.566528066528059	0.2525732283839387	0.8005980200264655	1.0	0.8825347876306169	2	P35580	1
+BRO1 domain [IPR004328]	0.550935550935543	0.2184564991372774	0.8270734484216364	1.0	0.9051900543379146	2	Q8WUM4	1
+GCF, C-terminal [IPR022783]	0.5460845460845379	0.2084864195525975	0.8348491852983284	1.0	0.9100339982409332	2	P16383	1
+Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]	0.5446985446985365	0.2056945271202186	0.8370295338748504	1.0	0.9115978665140352	2	P49588	1
+Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]	0.5446985446985365	0.2056945271202186	0.8370295338748504	1.0	0.9115978665140352	2	P49588	1
+Ubiquitin system component CUE [IPR003892]	0.4739944521497921	0.1991462218622385	0.842148365459108	1.0	0.915541464449764	4	Q9UKV5,Q9H1I8,Q9H4L7	3
+Zinc finger, RanBP2-type [IPR001876]	0.3501194140317948	0.194860675972842	0.8455020200428212	1.0	0.918626157656002	9	P35637,Q01844,Q92804	3
+GTP binding protein, second domain [IPR031662]	0.5374220374220291	0.1914522867323648	0.8481712586994616	1.0	0.9204521649002146	2	Q9Y295	1
+Glutathione S-transferase, C-terminal [IPR004046]	0.3357207000657584	0.1753797577473969	0.8607812450522583	1.0	0.9287776452571808	10	P78417	1
+Ubiquitin-associated domain [IPR015940]	0.3157144929777026	0.1684164959997819	0.8662556315281056	1.0	0.933860237692336	13	Q92995,Q14157,Q13501	3
+Domain of unknown function DUF1747 [IPR013719]	0.5183645183645098	0.1574696586674282	0.8748747184204564	1.0	0.9383468046277836	2	Q9Y5B9	1
+Rpn11/EIF3F, C-terminal [IPR024969]	0.4538834951456313	0.1558890898119706	0.8761204452395381	1.0	0.939112007282188	4	P51665,O00487,O00303	3
+Septin-type guanine nucleotide-binding (G) domain [IPR030379]	0.4487702762560621	0.1457205826895372	0.884141972175295	1.0	0.9456374111848628	4	Q16181	1
+Proteasome alpha-subunit, N-terminal domain [IPR000426]	0.348662444230813	0.1447122837983946	0.8849380401864264	1.0	0.9460749926785365	7	P60900	1
+Elongation factor 1 beta central acidic region, eukaryote [IPR018940]	0.5051975051974961	0.1367867810411851	0.8911993326252734	1.0	0.948208167218796	2	P29692	1
+Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]	0.5051975051974961	0.1367867810411851	0.8911993326252734	1.0	0.948208167218796	2	P29692	1
+E3 ligase, CCCH-type zinc finger [IPR041367]	0.5080250490656991	0.1247829123949019	0.9006954155812099	1.0	0.955701285441162	3	Q9UPT8	1
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.5077989601386519	0.1244490645285332	0.9009597273819868	1.0	0.955701285441162	3	P41240,Q9UHY1	2
+Cobalamin (vitamin B12)-binding domain [IPR006158]	0.4961884961884905	0.1239321674637343	0.901368983324057	1.0	0.955701285441162	2	Q99707	1
+B-box, C-terminal [IPR003649]	0.5071057192374389	0.1234289782092832	0.9017674112209764	1.0	0.9557092849741168	3	O15164,O15344	2
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.502894165865976	0.1173472622135973	0.9065848738845096	1.0	0.9599826836932116	3	Q9NUQ9	1
+Domain of unknown function DUF4749 [IPR031847]	0.477477477477471	0.1005022547268327	0.9199455928894584	1.0	0.9689158447079728	2	O00151	1
+Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]	0.4767844767844667	0.0997168490311318	0.92056912362234	1.0	0.9689158447079728	2	Q709C8	1
+Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]	0.4767844767844667	0.0997168490311318	0.92056912362234	1.0	0.9689158447079728	2	Q709C8	1
+Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]	0.4767844767844667	0.0997168490311318	0.92056912362234	1.0	0.9689158447079728	2	Q709C8	1
+Autophagy-related, C-terminal [IPR015412]	0.4767844767844667	0.0997168490311318	0.92056912362234	1.0	0.9689158447079728	2	Q709C8	1
+VPS13, repeated coiled region [IPR031642]	0.4767844767844667	0.0997168490311318	0.92056912362234	1.0	0.9689158447079728	2	Q709C8	1
+Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]	0.4767844767844667	0.0997168490311318	0.92056912362234	1.0	0.9689158447079728	2	Q709C8	1
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.3256991399025314	0.0879497296201148	0.9299166311864588	1.0	0.9754195992020476	8	Q92905,O15372,O00303	3
+Dbl homology (DH) domain [IPR000219]	0.4656964656964554	0.0879204379546343	0.9299399123680872	1.0	0.9754195992020476	2	O75962	1
+THUMP domain [IPR004114]	0.4650034650034547	0.0872304197582387	0.9304883600376036	1.0	0.975576346608894	2	Q9NXG2	1
+High mobility group box domain [IPR009071]	0.3048199664253271	0.0802024849218406	0.9360762138489352	1.0	0.9789163143116536	11	P26583,O96028,O15347	3
+NUC153 [IPR012580]	0.4521829521829464	0.0754282045587813	0.9398740191316296	1.0	0.9823585289170806	2	Q9BSC4	1
+Lamin tail domain [IPR001322]	0.4613518197573599	0.067714775307162	0.9460126873147032	1.0	0.984255753397638	3	Q03252,P20700	2
+Chromo shadow domain [IPR008251]	0.4564991334488743	0.0630928927322859	0.9496925338029852	1.0	0.9861264339698216	3	Q13185,P83916	2
+Chromo domain subgroup [IPR017984]	0.4564991334488743	0.0630928927322859	0.9496925338029852	1.0	0.9861264339698216	3	Q13185,P83916	2
+Gamma-adaptin ear (GAE) domain [IPR008153]	0.4320859320859255	0.0603721871061351	0.9518592097141256	1.0	0.9878165397924604	2	Q9UJY4	1
+DNA mismatch repair protein MutS, C-terminal [IPR000432]	0.4329289428076168	0.043843087837825	0.9650294809589384	1.0	0.9961831382422712	3	P52701,P43246	2
+DNA mismatch repair protein MutS, connector domain [IPR007860]	0.4329289428076168	0.043843087837825	0.9650294809589384	1.0	0.9961831382422712	3	P52701,P43246	2
+DNA mismatch repair protein MutS-like, N-terminal [IPR007695]	0.4329289428076168	0.043843087837825	0.9650294809589384	1.0	0.9961831382422712	3	P52701,P43246	2
+DNA mismatch repair protein MutS, core [IPR007696]	0.4329289428076168	0.043843087837825	0.9650294809589384	1.0	0.9961831382422712	3	P52701,P43246	2
+Importin-alpha, importin-beta-binding domain [IPR002652]	0.3793783958567562	0.0415622292941505	0.9668476838645848	1.0	0.9961831382422712	4	P52292	1
+Cadherin-like [IPR002126]	0.3905058905058823	0.040324378406046	0.96783451842499	1.0	0.996216621074607	2	Q14126	1
+DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]	0.3863478863478801	0.0389865374117376	0.9689011220432776	1.0	0.996216621074607	2	P28340	1
+DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]	0.3863478863478801	0.0389865374117376	0.9689011220432776	1.0	0.996216621074607	2	P28340	1
+SWIB/MDM2 domain [IPR003121]	0.3804573804573727	0.0372606869580076	0.9702771509735146	1.0	0.9971953064860206	2	P41214	1
+ABC-transporter extension domain [IPR032781]	0.3631323631323545	0.033205295841626	0.9735108749819424	1.0	0.9980873109925342	2	Q9NUQ8	1
+Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]	0.3579348579348481	0.0322479322573939	0.9742743316232784	1.0	0.9983657756994616	2	P20020	1
+Zinc finger, CW-type [IPR011124]	0.3506583506583451	0.0310796492808151	0.9752060193498656	1.0	0.998483549962488	2	Q8NB78	1
+ROCK, Rho binding domain [IPR015008]	0.3291753291753199	0.0285991248178996	0.9771843100943074	1.0	0.9991729700561598	2	Q13464	1
+Threonine-tRNA ligase catalytic core domain [IPR033728]	0.3167013167013103	0.0276733670508513	0.9779226655805278	1.0	0.9991729700561598	2	Q9BW92	1
+EGF-like calcium-binding domain [IPR001881]	0.2678447678447603	0.0260929869696037	0.9791831707472975	1.0	1.0	2	P01130	1
+Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]	0.2902759639613536	0.0213460375157691	0.9829696195665604	1.0	1.0	10	Q96K76	1
+Ubiquitin specific protease domain [IPR028889]	0.2902759639613536	0.0213460375157691	0.9829696195665604	1.0	1.0	10	Q96K76	1
+Glutamine amidotransferase type 2 domain [IPR017932]	0.3885615251299819	0.0200933988744799	0.9839688660187624	1.0	1.0	3	Q06203,Q06210	2
+CSN8/PSMD8/EIF3K [IPR033464]	0.3861032461459638	0.0191760393325027	0.9847006719310484	1.0	1.0	3	Q99627	1
+YTH domain [IPR007275]	0.3536754507628297	0.0181182037666777	0.9855445558291892	1.0	1.0	4	Q7Z739,Q9Y5A9,Q9H6S0	3
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.35889548884887	0.0112117333696218	0.9910545184571922	1.0	1.0	3	P13674	1
+3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]	0.356672443674168	0.0107177012665539	0.9914486753462896	1.0	1.0	3	Q16836,Q08426	2
+3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]	0.356672443674168	0.0107177012665539	0.9914486753462896	1.0	1.0	3	Q16836,Q08426	2
+Ras GTPase-activating domain [IPR001936]	0.3462738301559763	0.0086711484356599	0.9930815112376944	1.0	1.0	3	Q13576,Q14C86	2
+Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]	0.3294036061026355	0.0023033260305695	0.9981622133467184	1.0	1.0	4	Q9H0H5,Q13464,Q92974	3
+PPM-type phosphatase domain [IPR001932]	0.2637781629116015	0.0021923912189995	0.9982507262964576	1.0	1.0	3	Q9H0C8,O15355	2

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome, subunit alpha/beta [IPR001353]"}