msigdb_reactome/result.tsv

Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
Neddylation	0.653095853516809	5.895180893390736	3.7427113763400585e-09	5.251010285631863e-06	5.251024062408101e-06	72	P28072,O60826,P25787,P62191,P20618,P28074,P62333,P51665,Q86VP6,Q9UBW8,P28070,P63208,Q9UNS2,P28066,P25786,Q13564,P49721,Q15291,Q99436,O14818,P35998,Q92530,P17980,P61289,P61201,P61962,P49720,Q8TBC4,Q13098,Q9UBI1,P48556,Q15008,P60900,Q15370,Q9Y5A7,Q06323,Q99460,Q8NEZ5,O75832,Q9BT78,P62195,P43686,Q92905,Q9UNM6,P61081,Q9BTE7,Q99627,Q7L5N1,O00231,O00487,P55036,P25788,O00232,Q9H9Q2,Q13200,P25789,O43242	57
Signaling by robo receptors	0.5067681346465399	5.765960370379118	8.119413850048764e-09	1.1391472795948749e-05	5.695768816510708e-06	138	Q9Y6N7,P28074,P51665,P28070,P42766,P25398,P49721,Q99436,Q01518,Q92530,P62861,P62854,P15880,Q15008,P30050,P46777,P46782,Q13177,O75832,P62857,P27635,P62195,P62888,P61513,P55036,P25788,O00232,Q8N8S7,P25789,P32969,Q15369,P28072,P20618,P18621,P62910,P62249,P35080,P17980,P62495,P17612,P62899,P62851,Q8TEY7,P60900,P46781,P46783,Q99460,P62273,P62280,P62841,P62913,Q9UNM6,P62847,P08708,O00487,P11940,P62906,P62829,P62269,P25787,P25786,O14818,P62081,P35268,P39019,P49720,P62750,P62701,P48556,P60866,Q15370,P63173,P23396,P15170,O00231,O43347,P28066,O43242,P62191,Q04637,P62333,P05388,P08865,P35998,P62266,P62753,P61289,Q16512,Q13617,Q06323,P07737,P62277,P62244,P61247,P43686,P46778,Q13200	97
Regulation of expression of slits and robos	0.5197308868946954	5.534582227732574	3.1197104867268443e-08	4.376858094063338e-05	1.1506928051530018e-05	124	Q9Y6N7,P28074,P51665,P28070,P42766,P25398,P49721,Q99436,Q92530,P62861,P62854,P15880,Q15008,P30050,P46777,P46782,O75832,P62857,P27635,P62195,P62888,P61513,P55036,P25788,O00232,P25789,P32969,Q15369,P28072,P20618,P18621,P62910,P62249,P17980,P62495,P62899,P62851,Q8TEY7,P60900,P46781,P46783,Q99460,P62273,P62280,P62841,P62913,Q9UNM6,P62847,P08708,O00487,P11940,P62906,P62829,P62269,P25787,P25786,O14818,P62081,P35268,P39019,P49720,P62750,P62701,P48556,P60866,Q15370,P63173,P23396,P15170,O00231,O43347,O43242,P28066,P62191,Q04637,P62333,P05388,P08865,P35998,P62266,P62753,P61289,Q13617,Q06323,P62277,P62244,P61247,P43686,P46778,Q13200	90
Antigen processing ubiquitination proteasome degradation	0.5814955116745472	5.525757843031546	3.280663735190098e-08	4.602665370219893e-05	1.1506928051530018e-05	91	P28072,O43242,P22314,P19474,P20618,P28074,P25787,P62191,P51665,P62333,Q7Z6Z7,Q15386,Q96J02,P28070,P63208,P25786,P49721,Q99436,Q9UNE7,O14818,O94822,P35998,Q92530,P17980,P61289,A0AVT1,P49720,Q8TBC4,P49459,P48556,Q15008,P60900,Q15370,Q06323,Q99460,Q16763,P55786,P46934,Q8NEZ5,P68036,O75832,P61088,P52888,Q9C0C9,P62195,P43686,Q9ULT8,Q9UNM6,P61081,O00231,O00487,P55036,P61086,P25788,O00232,P25789,Q9Y4B6,Q13200,Q96PU5,P29144,P28066	61
Mitotic g1 phase and g1 s transition	0.5907604751794969	5.470939063627	4.47657210175684e-08	6.280433571996499e-05	1.2561261317810292e-05	80	P30153,P28072,O43242,P25787,P62191,P20618,P28074,P00374,P62333,P51665,P28070,P63208,Q7L590,P31350,P25786,P49721,P09884,Q99436,O14818,P14635,P12004,P35998,Q92530,Q9NRF9,P11802,P17980,P30154,P56282,P42771,P49720,P06400,Q9UJA3,P48556,Q15008,P60900,Q14181,Q06323,Q99460,P06493,P49643,O75832,P63151,P62195,P43686,Q9UBD5,Q9UNM6,O00231,O00487,P55036,P25788,O00232,P04183,Q13416,Q13200,P25789,P04818,P49642,P28066	58
Signaling by interleukins	0.5250656474361324	5.221927801027205	1.7707000974296713e-07	0.0002483983896756	2.6470575278731484e-05	110	P30153,P28072,O43242,P25787,P09429,P20618,P28074,P40222,P62191,P51665,P62333,Q16658,P52907,P28070,P63208,P28066,Q13126,P17987,P25786,P05388,P49721,Q99436,Q14738,O14818,P35998,Q92530,P17980,P46108,P30154,P37837,P49720,O00459,P51452,P48556,Q15008,P27361,P60900,Q06323,P46109,Q99460,P28482,P07900,P78417,P26038,P23528,Q53EL6,Q06124,Q13177,O75832,P61088,P62195,Q9H3K6,P43686,Q9UNM6,O00170,P62993,Q15833,O00231,O00487,P55036,P25788,O00232,P14174,Q13200,P25789,P42224,Q02750,P63104	68
Dna replication	0.5526757748040618	5.208961280370469	1.8990073324691806e-07	0.000266395264523	2.6470575278731484e-05	92	P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P49736,P28070,P63208,P28066,Q7L590,P27694,Q9Y248,P25786,P49721,P09884,Q99436,Q9BRX5,P49005,O14818,P12004,P35998,Q92530,Q9NRF9,P17980,P61289,P56282,P49720,Q9UJA3,P48556,Q15008,P60900,Q14181,Q06323,Q99460,Q16763,P49643,P15927,O75832,P62195,P43686,Q9UBD5,Q9BRT9,Q9UNM6,P51530,O00231,O00487,P55036,P25788,O00232,P18858,Q13416,P40938,Q13200,P25789,P28340,P49642,P52294,P39748	61
The role of gtse1 in g2 m progression after g2 checkpoint	0.6936961967790634	5.208548627356251	1.9032347538333202e-07	0.0002669882136764	2.6470575278731484e-05	49	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q15691,P28070,P28066,P25786,P49721,Q99436,O14818,P14635,P35998,Q92530,P17980,P49720,Q13885,P48556,Q15008,P60900,Q06323,Q99460,P06493,P07900,O75832,P08238,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,P04350,Q9BUF5,Q13200,P25789,O43242	42
Synthesis of dna	0.5593631967481246	5.198022240460114	2.0142003451257167e-07	0.0002825524114289	2.6470575278731484e-05	86	P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P49736,P28070,P63208,P27694,Q9Y248,P25786,P49721,P09884,Q99436,Q9BRX5,P49005,O14818,P12004,P35998,Q92530,Q9NRF9,P17980,P61289,P56282,P49720,Q9UJA3,P48556,Q15008,P60900,Q14181,Q06323,Q99460,Q16763,P49643,P15927,O75832,P62195,P43686,Q9UBD5,Q9BRT9,Q9UNM6,P51530,O00231,O00487,P55036,P25788,O00232,P18858,Q13416,P40938,Q13200,P25789,P28340,P49642,P28066,P39748	59
Clec7a dectin 1 signaling	0.6911999198193585	5.187695443811737	2.129124263339024e-07	0.0002986715547163	2.6470575278731484e-05	49	O43865,P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,Q8TBC4,P48556,Q15008,P60900,Q06323,Q99460,O75832,P61088,P62195,P43686,Q9UNM6,P61081,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	39
Transcriptional regulation by runx2	0.6667422029795171	5.1848616963571175	2.1617522460201337e-07	0.0003032478839631	2.6470575278731484e-05	53	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,Q9UNE7,O14818,P14635,P35998,Q92530,P11802,P17980,P17931,P49720,P06400,P48556,Q15008,P27361,P60900,Q06323,Q99460,P06493,P28482,Q07812,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P42224,O43242	45
Fc epsilon receptor fceri signaling	0.6530561029628159	5.176237275693786	2.264054906225052e-07	0.0003175964948555	2.6470575278731484e-05	55	O43865,P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P49720,O00459,P48556,Q15008,P27361,P60900,Q06323,Q99460,P28482,Q13177,O75832,P61088,P62195,P43686,Q9UNM6,P62993,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	43
Hedgehog off state	0.6609857770814936	5.134213626058505	2.8332613701061634e-07	0.0003974276312476	2.9287086498219932e-05	53	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q96J02,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,Q2M1P5,P35998,Q92530,P17980,Q9Y366,P49720,Q13885,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,P04350,Q9BUF5,Q13200,P25789,O43242	41
Dna replication pre initiation	0.6022101494302968	5.128380941379545	2.92244626495849e-07	0.000409935224474	2.9287086498219932e-05	65	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P49736,P28070,P28066,Q7L590,P27694,P25786,P49721,P09884,Q99436,O14818,P35998,Q92530,Q9NRF9,P17980,P61289,P56282,P49720,Q9UJA3,P48556,Q15008,Q14181,P60900,Q06323,Q99460,P49643,P15927,O75832,P62195,P43686,Q9UBD5,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13416,Q13200,P25789,P52294,P49642,O43242	49
Mitotic g2 g2 m phases	0.5398644853531352	5.073193666339171	3.911940026243997e-07	0.0005486947050091	3.6589679045562386e-05	93	P30153,P28072,P07437,P25787,O43242,P20618,P28074,P62191,P62333,P51665,Q7Z4H7,P61163,Q15691,Q9H6D7,P28070,P63208,P25786,P49721,Q99436,Q14204,O14818,O14974,P14635,P35998,Q92530,P17980,P30154,P49720,Q13885,P48556,Q15008,P60900,Q06323,Q99460,Q96CW5,P06493,O75330,P07900,P61981,O75832,Q9BSJ2,P63151,P08238,P62195,P43686,P43034,Q9UNM6,P23258,O00231,O00487,P55036,P25788,O00232,P04350,Q14203,Q9Y570,Q9BUF5,Q13200,P25789,P28066	60
C type lectin receptors clrs	0.6459711739989409	5.055515957535316	4.292287345438753e-07	0.0006020267529383	3.668817759743801e-05	54	O43865,P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P49720,Q8TBC4,P48556,Q15008,P60900,Q06323,Q99460,Q13177,O75832,P61088,P62195,P43686,Q9UNM6,P61081,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	41
Mapk family signaling cascades	0.5392770222185128	5.006303016372647	5.548538740719496e-07	0.0007781572797569	3.668817759743801e-05	89	P30153,P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,Q16181,P53041,P28070,O75608,P25786,P30086,O43924,P49721,Q99436,Q14738,O14818,P35998,Q92530,P17980,P61289,P30154,P49720,Q16512,Q99956,O00459,Q96P70,P48556,Q15008,P27361,P60900,Q06323,Q99460,P06493,P28482,P36507,Q06124,Q13177,O75832,P62195,P43686,Q9UNM6,P04792,P62993,Q9Y490,Q12959,O00231,O00487,P55036,P46940,P41240,P25788,O00232,P18206,Q13200,P25789,Q15334,Q02750,P28066	62
Tcr signaling	0.6694791801450612	5.004435757673273	5.602589190286511e-07	0.0007857346323423	3.668817759743801e-05	49	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P49720,O00459,P48556,Q15008,P60900,Q06323,Q99460,Q13177,O75832,P61088,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	39
Mapk6 mapk4 signaling	0.6594695684607979	4.966499414475238	6.817225890435382e-07	0.0009559998591336	3.745549691743726e-05	50	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q16181,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P49720,P48556,Q15008,P60900,Q06323,Q99460,P06493,Q13177,O75832,P62195,P43686,Q9UNM6,P04792,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	39
Regulation of mrna stability by proteins that bind au rich elements	0.5938096863187703	4.951857787445795	7.350831748575132e-07	0.001030790443547	3.745549691743726e-05	62	P28072,P62191,P25787,Q04637,P20618,P28074,O43242,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P39687,P49720,Q01105,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,P04792,O00231,O00487,P55036,P25788,O00232,P25789,P11940,Q13200,Q9Y2L1,P63104	41
Orc1 removal from chromatin	0.646802850150079	4.905126428098902	9.336718065337428e-07	0.0013090845563797	3.745549691743726e-05	51	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,Q9UJA3,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UBD5,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13416,Q13200,P25789,O43242	38
Dectin 1 mediated noncanonical nf kb signaling	0.7071653401199806	4.9029840946286685	9.43916299110098e-07	0.0013234386742811	3.745549691743726e-05	42	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,Q8TBC4,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,P61081,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	37
Downstream signaling events of b cell receptor bcr	0.6933210541254045	4.899352743108914	9.615288332876203e-07	0.0013481160756678	3.745549691743726e-05	44	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P62942,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Switching of origins to a post replicative state	0.594450473709707	4.868700500130064	1.1233450953884727e-06	0.0015748127330825	3.745549691743726e-05	59	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,Q9UJA3,P48556,Q15008,P60900,Q06323,Q99460,Q16763,O75832,P62195,P43686,Q9UBD5,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13416,Q13200,P25789,O43242	39
Apc c mediated degradation of cell cycle proteins	0.6056799481896431	4.854665648573725	1.2059003196007725e-06	0.0016904487477732	3.745549691743726e-05	57	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,O60566,P49721,Q99436,O14818,P14635,P35998,Q92530,P17980,P49720,P06400,P48556,Q15008,P60900,Q06323,Q99460,Q16763,P06493,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	40
Cyclin a cdk2 associated events at s phase entry	0.6869491185669595	4.848191412230528	1.2459215403826107e-06	0.0017465020972274	3.745549691743726e-05	44	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P11802,P17980,P49720,P06400,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	37
S phase	0.513157542105023	4.846790857176334	1.254745798373591e-06	0.0017588608476839	3.745549691743726e-05	99	P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P49736,P28070,P63208,P27694,Q9Y248,P25786,P49721,P09884,Q99436,Q9BRX5,P49005,O14818,P12004,P35998,Q92530,Q9NRF9,P11802,P17980,P61289,P56282,P49720,P06400,Q9UJA3,P48556,Q15008,P60900,Q14181,Q06323,Q99460,Q16763,P49643,P15927,O75832,P62195,P43686,Q9UBD5,Q9BRT9,Q9UNM6,P49841,P51530,O00231,O00487,P55036,P25788,O00232,P18858,Q13416,P40938,Q13200,P25789,P28340,P49642,P28066,P39748	62
Pcp ce pathway	0.6571753718680309	4.835156037593117	1.3304123398505396e-06	0.0018648287965165	3.8000909195943605e-05	48	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,P07737,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	35
Nervous system development	0.3864588377731678	4.827977416087424	1.3792673061452376e-06	0.0019332422403157	3.8000909195943605e-05	222	Q9Y6N7,P28074,P51665,P28070,P35579,P42766,P25398,P49721,Q99436,Q01518,Q92530,P62861,P62854,O00459,P15880,Q96P70,Q15008,P27361,Q96S59,P30050,P46777,P46782,Q13177,O75832,P62857,P27635,P62195,P62888,P61513,P55036,P25788,O00232,Q8N8S7,Q9BUF5,P25789,Q02750,P32969,Q15369,P28072,P06756,P20618,P18621,P62910,Q16555,P62249,P35080,P07942,P17980,P62495,P17612,P62899,Q00535,Q13885,O15145,O95239,Q8TEY7,P62851,P60660,P60900,P46781,Q14195,P46783,Q99460,P62273,P62280,Q06124,P62841,P62913,Q9UNM6,P62847,Q9Y490,Q12959,P08708,O00487,P04350,P11940,P62906,P62269,P62829,P25787,P25786,P35241,O14818,P62081,P35268,P39019,P49720,P62750,P62701,P48556,P60866,Q15370,P28482,P26038,P63173,P23396,P08238,P15311,P62993,P15170,O15143,O00231,O43347,P28066,O43242,P62191,Q04637,P62333,P05388,P08865,P35998,P62266,P62753,P61289,Q16512,Q13617,Q06323,P07737,P07900,P23528,P62277,P36507,P62244,P61247,P43686,P11142,P49841,P50570,P46778,Q13200,Q15334	131
Auf1 hnrnp d0 binds and destabilizes mrna	0.6970082188621967	4.8234780225787635	1.4107631818305322e-06	0.0019773446135173	3.8000909195943605e-05	42	P28072,P62191,P25787,Q04637,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,P04792,O00231,O00487,P55036,P25788,O00232,P11940,Q13200,P25789,O43242	38
Interleukin 1 family signaling	0.6480227743759847	4.820115558671828	1.4347508903167494e-06	0.0020109323040661	3.8000909195943605e-05	49	P28072,P62191,P25787,P09429,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,Q06124,O75832,P61088,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,Q02750,O43242	39
Cdt1 association with the cdc6 orc origin complex	0.7049251859352295	4.819891442424315	1.4363635938430264e-06	0.0020131903778187	3.8000909195943605e-05	41	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,Q9UJA3,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UBD5,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13416,Q13200,P25789,O43242	37
Signaling by the b cell receptor bcr	0.6612343479537692	4.808166097649538	1.5232118530938976e-06	0.0021347859537994	3.8000909195943605e-05	47	O43865,P28072,P62191,P25787,P20618,P28074,P62333,P51665,P62942,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,P62993,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	38
Negative regulation of notch4 signaling	0.718730623125704	4.801991065156679	1.5709570444499832e-06	0.0022016273200748	3.8000909195943605e-05	39	P28072,P62191,P25787,O43242,P20618,P28074,P62333,P51665,P63104,P28070,P63208,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P28066	36
Hedgehog on state	0.6871149597798334	4.796310513511439	1.616146918070882e-06	0.0022648872219305	3.817738344567489e-05	43	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q96J02,P28070,P28066,P25786,P49721,Q99436,O14818,Q2M1P5,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Regulation of runx2 expression and activity	0.6855165471977063	4.783539408988506	1.722351039568082e-06	0.0024135432989347	3.882405210416329e-05	43	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,Q9UNE7,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P42224,O43242	37
Degradation of gli1 by the proteasome	0.6899926538094964	4.768185829420721	1.8589227965826185e-06	0.0026046730450291	4.0124133593951023e-05	42	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q96J02,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Signaling by hedgehog	0.5750866574698457	4.763862007765781	1.8992240986559496e-06	0.0026610670081408	4.037290015781364e-05	62	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q96J02,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,Q2M1P5,P35998,Q92530,P17980,Q9Y366,P49720,Q13885,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,P04350,Q9BUF5,Q13200,P25789,O43242	41
Beta catenin independent wnt signaling	0.6191428096112321	4.758411136591704	1.9512275841737647e-06	0.0027338312300886	4.085928806861485e-05	53	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,P07737,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	35
G2 m checkpoints	0.5262417089474515	4.755262851430948	1.9818838463692146e-06	0.0027767235437844	4.0890927006726626e-05	81	P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,Q9UQ84,P49736,P28070,P28066,Q7L590,P27694,P24941,P25786,P49721,Q99436,O14818,P14635,P35998,Q92530,P17980,P61289,P27348,P49720,Q9UJA3,P48556,Q15008,P60900,Q06323,Q99460,P06493,Q04917,P61981,P15927,O75832,P61088,O96017,P62195,P43686,Q9UBD5,Q9UNM6,P54132,P51530,O00231,O00487,P55036,P25788,O00232,Q13416,P40938,Q13200,P25789,P63104	55
Scf skp2 mediated degradation of p27 p21	0.6957506704007145	4.748631095795495	2.0479811730922393e-06	0.002869196493512	4.104739408356878e-05	41	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P11802,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Regulation of pten stability and activity	0.6939402760987058	4.734507865538058	2.195872562227308e-06	0.0030760717540336	4.278901673342105e-05	41	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,Q9UNE7,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,P46934,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Interleukin 1 signaling	0.6497065277501749	4.710541288030064	2.470597407988606e-06	0.0034602519273666	4.7210521782450265e-05	47	P28072,P62191,P25787,P09429,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P61088,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,Q02750,O43242	38
Regulation of runx3 expression and activity	0.721421384753254	4.70894049878862	2.4900774140412807e-06	0.0034874875009929	4.7210521782450265e-05	37	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P42771,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	35
Cellular response to hypoxia	0.6953429999762305	4.683527453774033	2.81979666327814e-06	0.0039483649248629	5.2748996247741784e-05	40	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P49720,P48556,Q15008,P60900,Q15370,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Metabolism of polyamines	0.7101815514584658	4.680233995076783	2.8654767922908775e-06	0.0040121992341259	5.289820973138821e-05	38	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,P19623,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	35
Degradation of beta catenin by the destruction complex	0.6240432505088629	4.655537243084872	3.231369859024724e-06	0.0045233578982815	5.738749255965938e-05	50	P30153,P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,Q14738,O14818,P35998,Q92530,P17980,P30154,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	38
Fceri mediated nf kb activation	0.6558431091053502	4.648113914595339	3.349839120092568e-06	0.0046888052278524	5.874780356864095e-05	45	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P61088,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Tnfr2 non canonical nf kb pathway	0.6739985521325933	4.640953605771016	3.4680499043648898e-06	0.0048538641959097	5.933748799787003e-05	42	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,Q8TBC4,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,P61081,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	37
Runx1 regulates transcription of genes involved in differentiation of hscs	0.6812328515090678	4.634795236228025	3.572909691884618e-06	0.0050002581321395	6.03950879242834e-05	41	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q96J02,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	35
Degradation of axin	0.7094934034060224	4.620554669090739	3.827154776203656e-06	0.0053551183829628	6.392259703589444e-05	37	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
Regulation of ras by gaps	0.7000452863610185	4.603860903045569	4.147295165957132e-06	0.0058017715257691	6.709881012776647e-05	38	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
Degradation of dvl	0.7000452863610185	4.603860903045569	4.147295165957132e-06	0.0058017715257691	6.709881012776647e-05	38	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
Transcriptional regulation by runx3	0.6771748193069489	4.602736325223968	4.169759949324003e-06	0.0058331063925663	6.709881012776647e-05	41	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P25440,P42771,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Stabilization of p53	0.6846844051463881	4.600804594519144	4.208621020129755e-06	0.0058873091912274	6.709881012776647e-05	40	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P42771,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Asymmetric localization of pcp proteins	0.6991470750015472	4.5970638016656125	4.284864405068589e-06	0.0059936436621609	6.754679505969251e-05	38	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
G1 s dna damage checkpoints	0.6718236444657796	4.560299017984118	5.1080831338090604e-06	0.0071410396785478	7.760075914754512e-05	41	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P42771,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1	0.613282813765192	4.559161381300793	5.135829463043251e-06	0.0071796892370368	7.760075914754512e-05	50	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P06400,P48556,Q15008,P60900,Q06323,Q99460,Q16763,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Regulation of hmox1 expression and activity	0.6451688823259035	4.558832197348552	5.143884961311684e-06	0.0071909099515009	7.760075914754512e-05	45	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	35
Programmed cell death	0.4852673634579766	4.525931717202307	6.012999412607911e-06	0.0084007781264977	8.974721463713088e-05	101	P28072,O43242,P25787,P09429,P20618,P28074,Q8WUM4,P62191,P51665,P62333,P28070,P28066,Q13625,Q16543,P25786,P49721,Q99436,Q9UNE7,O14818,P35998,Q92530,Q9P289,P17980,P61289,P27348,P42771,P49720,P48556,Q15008,P27361,P60900,Q9Y3E7,P49327,Q06323,Q8WUX9,Q99460,Q13546,Q9H444,P28482,P26583,Q07812,P07900,Q04917,P61981,Q13177,O75832,P62195,P43686,Q9UJU6,Q9UNM6,O00231,O00487,P55036,P25788,O00232,O00273,Q13200,P25789,P52294,P63104	60
Adaptive immune system	0.385089430421185	4.468646432793924	7.871611743315299e-06	0.0109831545985338	0.0001162512765881	191	P22314,P19474,P28074,P51665,P28070,P49721,Q99436,Q9BXS5,O94822,Q92530,Q8TBC4,O00459,Q15008,Q16763,P55786,P46934,Q13177,O75832,P61088,P62195,P55036,P61086,P52732,P25788,O00232,Q9BUF5,Q96PU5,P25789,P30153,P28072,P06756,P20618,P62942,P61163,P52907,Q9NZ32,Q14738,Q9Y6G9,P17980,P30154,A0AVT1,Q13885,P60900,Q99460,Q06124,Q9C0C9,Q9ULT8,Q9UNM6,P61081,O00487,P04350,P63104,O43865,P25787,P09429,Q15386,Q96J02,P63208,Q9H0H5,P25786,Q14204,Q9UNE7,O14818,P49720,P49459,P48556,Q15370,Q8NEZ5,O94979,P62993,O00231,Q14203,P29144,O43242,P62191,P47755,P62333,Q7Z6Z7,Q06323,O43237,P68036,P52888,P43686,Q9UJW0,Q9Y4B6,Q13200,Q10567	87
Signaling by notch4	0.6442490328187606	4.447936675690797	8.669907908043228e-06	0.0120902519409705	0.0001267070916144	43	P28072,P62191,P25787,O43242,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P63104	36
Apoptosis	0.4883899055768478	4.38987548436294	1.1341558394661888e-05	0.0157863649097136	0.0001575465982941	89	P28072,O43242,P25787,P09429,P20618,P28074,P62191,P62333,P51665,P28070,P28066,Q13625,P25786,P49721,Q99436,O14818,P35998,Q92530,Q9P289,P17980,P61289,P27348,P42771,P49720,P48556,Q15008,P27361,P60900,P49327,Q06323,Q99460,Q13546,P28482,P26583,Q07812,Q04917,P61981,Q13177,O75832,P62195,P43686,Q9UJU6,Q9UNM6,O00231,O00487,P55036,P25788,O00232,O00273,Q13200,P25789,P52294,P63104	53
Signaling by wnt	0.4909549719709282	4.375789427367022	1.2099377732166516e-05	0.0168322572056972	0.0001599800823406	85	P30153,P28072,O43242,P25787,Q96QK1,P20618,P28074,P62191,P62333,P51665,P28070,P63208,P28066,Q9UBQ0,P25786,P49721,Q15291,Q99436,Q14738,O14818,O60493,Q92530,P35998,P17980,P30154,P49720,P48556,Q15008,P60900,Q06323,P07737,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P63104	44
Intracellular signaling by second messengers	0.4841863651172018	4.337421979210825	1.4416368332437202e-05	0.0200231309102655	0.0001822177006343	89	P30153,O43865,P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P28070,Q8TBX8,Q15382,P25786,P49721,Q99436,Q14738,Q9UNE7,O14818,P35998,Q92530,P17980,P61289,P30154,P49720,O00459,P48556,Q15008,P27361,P60900,Q06323,Q99460,P28482,P46934,Q06124,O75832,P62195,P43686,Q9UNM6,P62993,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P28066	48
Tcf dependent signaling in response to wnt	0.5330977850392389	4.329618738444949	1.4936771635110093e-05	0.0207383866911326	0.0001871097375362	62	P30153,P28072,P62191,P25787,O43242,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q15291,Q99436,Q14738,O14818,P35998,Q92530,P17980,P30154,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P63104	39
Uch proteinases	0.6113575612822545	4.323404461497944	1.536396885559732e-05	0.0213251477119334	0.0001907579495964	46	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,Q9Y5K5,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	35
Ub specific processing proteases	0.4928288223157988	4.316872242764293	1.582556925461276e-05	0.0219587670503169	0.000194765558458	76	P54578,P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,P45974,Q96K76,Q99436,O14818,O60493,P35998,Q92530,P17980,P61289,P49720,Q14694,P48556,Q8TEY7,Q15008,P60900,Q06323,Q99460,Q13546,Q12962,O75832,Q9NZL9,P43686,P62195,Q9UNM6,Q96FW1,Q13200,O00231,O00487,P55036,O14964,P25788,O00232,P14735,P51784,P25789,O43242	48
Metabolism of amino acids and derivatives	0.3793333163821907	4.306176363168324	1.6610064665245616e-05	0.0230346705042168	0.0001991788096182	188	P00390,P28074,P51665,P28070,P42766,Q13126,P25398,P49721,P47897,Q99436,Q92530,P62861,P62854,P14868,P15880,Q15008,P30050,Q9P2J5,P46777,P46782,O75832,P07814,P62857,P27635,P34896,P62195,P41252,P61457,P62888,P55036,P25788,O00232,P25789,P32969,P28072,P20618,P17980,O43252,P62851,P60900,P46783,Q99460,P62841,P62913,Q9UNM6,P62847,P08708,O00487,P21953,P62906,P62829,P62269,P25787,Q16881,P17174,P25786,O14818,P62081,P25325,P12277,P35268,P16930,P39019,P49720,P62750,P62701,P48556,P60866,P08243,P63173,P23396,Q99707,P19623,O00231,O43324,O43175,P54136,P28066,O43242,P49591,P62191,Q7L266,P62333,Q15046,P05388,P08865,P23526,P35998,P62266,P62753,P61289,Q06323,P62277,P62244,P61247,P57772,P43686,P46778,Q9Y617,Q13200	100
Eukaryotic translation initiation	0.468132640819823	4.284961906588432	1.8277050200410372e-05	0.0253169480644547	0.0002173110290777	100	P55010,Q04637,P18621,Q14240,P62910,P42766,P25398,P62249,P06730,Q9Y262,O15371,P05388,P08865,Q14152,Q14232,P62266,P62861,P62081,P62753,P62854,P35268,P62899,P39019,P62750,P62701,P15880,P62851,P60866,Q13347,P30050,P46781,P46783,P60842,P62273,P62280,P05198,P46777,Q15056,P46782,P63173,P23396,P62277,P62244,P61247,P62841,P62857,P27635,Q9NR50,O00303,P62913,P62847,P62888,O15372,P60228,P23588,P55884,Q13144,P08708,P61513,P62269,P46778,O75821,P11940,O75822,P49770,P62906,P62829,O60841,P32969	69
Pten regulation	0.5130642425441971	4.249691729770954	2.140649130044636e-05	0.029587100775892	0.0002409924170863	67	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,Q15382,P25786,P49721,Q99436,Q9UNE7,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P27361,P60900,Q06323,Q99460,P28482,P46934,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	39
Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s	0.5737620986477456	4.241041856781966	2.2248463761531667e-05	0.0307327854533034	0.000245784209901	51	Q04637,Q14240,Q9Y262,P25398,P62249,P06730,O15371,P08865,Q14152,P62266,P62861,P62081,P62753,P62854,P39019,P62701,P15880,P62851,Q13347,P60866,P46781,P46783,P60842,P62273,P62280,P05198,Q15056,P46782,P62277,P23396,P62244,P61247,O00303,P62841,P62857,P62847,O15372,P60228,P23588,P55884,P08708,P62269,P11940,O75821,O75822	45
Cell cycle mitotic	0.3377170532457055	4.214094686241586	2.507820679364947e-05	0.0345733638295137	0.0002727497994689	261	Q14739,P28074,P00374,P51665,P28070,P49721,Q99436,Q9BRX5,P49005,Q92530,Q9NRF9,Q6IBW4,O95347,P06400,Q9UJA3,Q15008,P27361,Q16763,P49643,O75832,P62195,Q9BRT9,Q9P258,P55036,P25788,O00232,O60763,Q9BUF5,P25789,P04818,P28340,P30153,P28072,P20618,Q8NBT2,Q7Z4H7,P61163,Q15691,Q15003,Q7L590,Q96GX5,Q9UN37,Q14738,O14974,Q9Y6G9,Q9HC35,P11802,P17980,P30154,P42771,Q13885,Q01105,P60900,Q9Y3E7,Q99460,Q96CW5,P06493,O75330,Q9BSJ2,Q9UBD5,Q9UNM6,O00487,P18858,P04350,Q9H8Y8,P49642,P07437,P25787,P63208,Q9BPX3,P31350,P25786,Q15021,Q14204,O14818,Q9NTJ3,P56282,P49720,Q14181,Q9H444,P28482,P08238,P23258,Q14203,Q13416,O43242,P39748,P62191,P62333,Q9H6D7,P09884,P12004,Q06323,O43237,P07900,P63151,P62826,P43686,P43034,Q99986,Q9Y266,Q9Y570,Q13200	103
Hedgehog ligand biogenesis	0.6158120377773371	4.209767762564249	2.5563331879752127e-05	0.0352302556968798	0.0002758873432868	43	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
Sumo is conjugated to e1 uba2 sae1	0.9432223543400706	4.1785701352208955	2.933475377986383e-05	0.0403218040083197	0.0003071392503966	2	Q9UBE0	1
Sumo is transferred from e1 to e2 ube2i ubc9	0.9432223543400706	4.1785701352208955	2.933475377986383e-05	0.0403218040083197	0.0003071392503966	2	Q9UBE0	1
Processing and activation of sumo	0.9432223543400706	4.1785701352208955	2.933475377986383e-05	0.0403218040083197	0.0003071392503966	2	Q9UBE0	1
Selenoamino acid metabolism	0.4713778967694314	4.164762047028411	3.116774607225814e-05	0.0427867008222115	0.0003215319686719	88	P49591,P00390,P18621,Q16881,P62910,P42766,P25398,P62249,P56192,Q15046,P05388,P47897,P08865,P23526,P62266,P62861,P62081,P62753,P62854,P35268,P62899,O43252,P39019,P62750,P62701,P14868,P15880,P62851,P60866,P30050,P46781,P46783,P62273,Q9P2J5,P46777,P63173,P46782,P23396,P62277,P62244,P07814,P61247,P62841,P62857,P27635,P57772,P41252,P62913,P62847,P62888,P08708,O43324,P61513,P62269,P46778,P54136,P62906,P62829,P32969	59
Signaling by notch	0.5170833417623073	4.132447631520272	3.5892055930908384e-05	0.049110539485254	0.0003622773702954	61	P28072,P62191,P25787,O43242,P20618,P28074,P62333,P51665,Q96J02,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,P67809,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P42224,P63104	39
Innate immune system	0.3065411274265709	4.085538970375894	4.397461865979224e-05	0.0598329874335946	0.0004225780135595	302	P19474,P28074,P06737,Q9UI12,P51665,P42785,Q13442,P50395,P28070,P35579,P21281,P49721,P63167,P46976,Q99436,Q9BXS5,Q01518,P84095,Q92530,P55072,P53990,P46108,Q9Y376,Q8TBC4,P13639,O00459,Q15008,P27361,Q13546,Q13177,O75832,P61088,P62195,Q15366,P18669,P55036,P61086,P25788,O00232,P50990,P09960,P11216,P14174,P25789,P35573,Q02750,P30153,P28072,P06756,P20618,Q86VP6,P52907,Q9NZ32,P07741,Q14738,Q9Y6G9,P17980,P21283,P30154,P09972,P60900,Q99460,Q06124,Q9UJU6,Q9UNM6,P61081,Q9Y5Z4,P04075,P78371,O00487,O60610,Q9H1D9,P13010,P18206,P06744,P48960,O43865,P31949,P00491,P07437,P25787,P09429,P35240,Q9UQ80,Q96J02,P63208,P36871,P25786,Q9Y6W5,Q14204,O14818,P17931,P49720,P51452,P53396,P48556,Q13526,Q9UQB8,P28482,P30041,Q14019,P08238,Q9NQR4,P62993,O15143,O00231,O75787,P37108,P28066,O43242,Q96G03,P62191,P47755,Q6SZW1,P62333,Q7Z6Z7,Q9Y5K8,Q15075,P13798,P02792,P35998,P61289,Q96JJ3,Q16512,Q9UBI1,Q06323,P04080,P07900,P14618,P23528,Q9Y2Z0,P43686,P11142,P12268,P0DMV9,P17858,P50570,P46940,Q99538,Q9NW08,Q99439,Q96F07,Q13200,Q14258	144
Class i mhc mediated antigen processing presentation	0.4287858444920662	4.06358456959224	4.8324802208732365e-05	0.0655539038336047	0.0004581060641814	117	P28072,P62191,P22314,P19474,P06756,P28074,P20618,P25787,P51665,P09429,P62333,Q7Z6Z7,Q15386,Q96J02,P28070,P63208,P25786,P49721,Q99436,Q9UNE7,O14818,O94822,Q92530,P17980,A0AVT1,P49720,Q8TBC4,P49459,P48556,Q15008,P60900,Q15370,Q06323,Q99460,Q16763,P55786,P46934,Q8NEZ5,P68036,O75832,O94979,P61088,P52888,Q9C0C9,P62195,P43686,Q96PU5,Q9ULT8,Q9UNM6,P61081,O00231,O00487,P55036,P61086,P25788,O00232,Q9Y4B6,Q13200,P25789,P29144,O43242	61
Cytokine signaling in immune system	0.3707015804508766	4.0464627305351915	5.199739883243737e-05	0.0703566372476502	0.000486349003746	182	P19474,P28074,P51665,P28070,Q13126,P49721,Q99436,Q92530,P46108,O15344,Q8TBC4,O00459,P19525,Q15008,P27361,P46109,P60842,P46934,Q53EL6,Q13177,O75832,P61088,P62195,Q9Y3Z3,P55036,P25788,O00232,P14174,P25789,Q02750,P30153,P28072,P20618,P52907,Q14738,P17980,P30154,P60900,Q99460,Q06124,Q9H3K6,Q9UNM6,P61081,O00487,P63104,P25787,P09429,P40222,Q14240,P63208,P06730,P17987,P25786,O14818,P37837,P49720,P61221,Q13325,P51452,P48556,Q15370,Q13526,P28482,P78417,P26038,O00170,P62993,Q15833,O00231,P42224,P52294,O43242,P28066,P62191,Q04637,P62333,Q16658,P05388,P35998,Q12899,Q06323,O60573,P07900,P23528,P43686,Q13200,Q14258,P29372	88
Defective cftr causes cystic fibrosis	0.5901821884239604	4.0366469778441925	5.422056232418093e-05	0.0732519224319423	0.0004939704476677	44	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
Deubiquitination	0.4561046380376715	4.027349074335527	5.64092536290417e-05	0.0760935112388433	0.0005105947280099	93	P54578,P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P28070,Q9Y5K5,P25786,P49721,P45974,Q99436,Q96K76,O14818,O60493,Q92530,P35998,P17980,P61289,P49720,P54727,P48556,Q8TEY7,Q15008,P60900,Q06323,Q99460,Q13546,Q12962,P06493,O75832,P62195,Q9NZL9,P43686,Q9UNM6,Q96FW1,Q13200,O00231,O00487,Q6GQQ9,P55036,O14964,P25788,O00232,Q14258,P14735,P51784,P25789,P28066	52
Cellular response to chemical stress	0.4752412364070584	3.967928716144103	7.25000111923002e-05	0.0967186514305593	0.0006278858993999	72	P00390,P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q16881,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,P30041,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,P30043,O00232,Q13200,P25789,O43242	39
Cytoprotection by hmox1	0.4973431878666511	3.945045450399249	7.978484401149899e-05	0.1059044245574976	0.0006825870431642	62	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P63208,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,P30043,O00232,Q13200,P25789,O43242	36
Cell cycle	0.297812595131127	3.930393448668895	8.480697029522588e-05	0.1121826330160474	0.0007211162383285	307	Q14739,P28074,P00374,P51665,Q9UQ84,P28070,P49721,Q99436,P49005,Q9BRX5,Q92530,Q9NRF9,Q6IBW4,O95347,P06400,Q9UJA3,Q15008,P27361,Q16763,P49643,O75832,P61088,P62195,Q9BRT9,Q9P258,P55036,P25788,O00232,O60763,Q9BUF5,P25789,P04818,P28340,P30153,P28072,P20618,Q8NBT2,Q7Z4H7,P61163,Q15691,Q15003,Q7L590,Q96GX5,Q9UN37,Q14738,O14974,Q9Y6G9,Q9HC35,P11802,P17980,P30154,P42771,Q13885,Q01105,P60900,Q9Y3E7,Q99460,O75330,P06493,Q96CW5,Q9BSJ2,Q9UBD5,Q9UNM6,O00487,P18858,P04350,Q9H8Y8,P49642,P63104,P07437,P25787,P63208,Q9BPX3,P31350,P25786,Q15021,Q14204,Q9NPE3,O14818,Q9NTJ3,P27348,P56282,P49720,P48556,Q14181,Q9H444,P28482,P61981,P08238,P23258,O00231,Q14203,P04183,Q13416,P40938,O43242,P39748,P28066,P62191,P62333,Q9H6D7,Q9Y248,O60566,P09884,P14635,P12004,P35998,P61289,Q06323,Q8NFH4,Q8WUX9,O43237,P07900,P62820,Q04917,P15927,P63151,P62826,O96017,P43686,P43034,Q99986,P49841,P54132,Q9Y266,Q9Y570,Q13200	127
Infectious disease	0.2902446491149045	3.9186994715815984	8.902803525856484e-05	0.1174253406124918	0.0007524477919745	357	Q99720,Q9Y5B9,P28074,Q9UI12,P51665,Q15185,P28070,P35579,P42766,P25398,Q13409,P49721,Q96SB4,Q99436,P63167,Q9BXS5,Q92530,P62861,P55072,P46108,P62854,P06400,P13639,P15880,P19525,Q15008,P27361,P30050,Q13546,Q12962,P46777,P46782,P23193,O75832,Q13177,P62857,P62195,Q8IXH7,P55036,P25788,O00232,Q9H3P2,Q9BUF5,Q96PU5,P25789,Q02750,P35269,P32969,P28072,P20618,P62942,Q9UN37,Q9Y6G9,P17980,P42566,Q13885,P62851,P60900,Q9Y3E7,P46783,Q99460,P62841,P62913,P62847,Q9UNM6,P06733,P08708,P18074,O00487,O14964,P18858,P04350,P13010,P62906,P62269,P62829,O43865,P07437,P25787,Q8WUM4,Q16881,P63208,P25786,Q9Y6W5,Q14204,O14818,P62081,P35268,P39019,Q13263,P49720,P55199,P62750,P62701,P48556,P60866,Q15370,Q9BRG1,Q9H444,Q9UQB8,P28482,P63173,P23396,Q99816,P08238,P62993,O15143,O00231,P52294,O43242,P39748,P28066,P62191,P62333,Q99873,Q9NP79,P00558,P05388,P08865,P09874,P32780,P35998,P62266,Q00403,P62753,P61289,P49840,Q96JJ3,Q06323,Q8NFH4,Q02790,Q8WUX9,O43237,P07900,Q9Y2Z0,O75351,P62277,P36507,P62244,P62826,P61247,O75886,P43686,P43487,P12268,P49841,P46778,Q9H9H4,Q96F07,Q13200,Q10567	151
Cross presentation of soluble exogenous antigens endosomes	0.6111325043312676	3.9062809599339583	9.372752647807124e-05	0.1232258825936702	0.0007853628972698	38	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
Nonsense mediated decay nmd	0.4535505524833461	3.889797318824842	0.0001003279808844	0.1313084967375634	0.0008280009245933	83	P30153,Q04637,Q92900,P18621,P62910,P42766,P25398,P62249,P05388,P08865,P62266,P62861,P62081,P62753,P62854,P62495,P35268,Q8ND04,P62899,P39019,P62750,P62701,P15880,P62851,P60866,P30050,P46781,P46783,P62273,P62280,P46777,P63173,P46782,P23396,P62277,P62244,P63151,P61247,P62841,P62857,P27635,P62913,P62847,P62888,P15170,P08708,P61513,P62269,P46778,P11940,P62906,P62829,P32969	53
Eukaryotic translation elongation	0.4564890366940382	3.8755133284263183	0.0001064001552457	0.1386784300758363	0.0008729790515193	76	P29692,P18621,P62910,P42766,P25398,P62249,P05388,P08865,P62266,P62861,P62081,P62753,P62854,P35268,P24534,P62899,P39019,P62750,P13639,P62701,P15880,P62851,P60866,P30050,P46781,P46783,P62273,P46777,P63173,P46782,P62277,P23396,P62244,P61247,Q05639,P62841,P62857,P27635,P62913,P62847,P62888,P08708,P46778,P61513,P26641,P62269,P62906,P62829,P32969	49
Developmental biology	0.3177582142471012	3.868204002418518	0.0001096399221289	0.1425850118441591	0.0008937228077186	270	Q9Y6N7,P28074,P51665,P28070,P35579,P42766,P25398,P24941,P49721,Q99436,Q01518,Q92530,P62861,P62854,O00459,P15880,Q96P70,Q15008,P27361,Q96S59,P30050,P46777,P46782,Q13177,O75832,P62857,P27635,P62195,P62888,P61513,P55036,P25788,O00232,Q8N8S7,Q9BUF5,P25789,Q02750,P32969,Q15369,P28072,P06756,P20618,Q71SY5,P18621,P62910,Q16555,P62249,P35080,P07942,P11802,P17980,Q09028,P62495,P17612,P62899,Q00535,Q13885,O15145,O95239,Q8TEY7,P62851,P60660,P60900,P46781,Q14195,P46783,Q99460,P62273,P62280,Q06124,P62841,P62913,Q9UNM6,P62847,Q9Y490,Q12959,P08708,O00487,P04350,P11940,P62906,P62269,P62829,P25787,P25786,Q15291,P35241,O14818,O60244,P62081,P35268,P39019,P49720,P62750,P62701,P48556,P60866,Q15370,P28482,P26038,P63173,P23396,P08238,P15311,P62993,P15170,O15143,O00231,O43347,P28066,O43242,P62191,Q04637,P62333,Q96EK7,P05388,P08865,P24468,P35998,P62266,P62753,P61289,Q16512,Q13617,Q06323,P07737,P07900,P23528,P62277,P36507,P62244,P61247,O60271,P43686,P11142,P49841,P50570,P46778,Q13200,Q15334	140
Diseases of signal transduction by growth factor receptors and second messengers	0.378686477342119	3.8403375489984817	0.0001228652549509	0.1583495919680502	0.0009850283011212	150	P30153,P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P62942,P28070,P63208,P28066,Q16543,Q92734,P25786,P30086,P49721,Q99436,Q14738,O14818,P35998,Q92530,Q9HC35,P17980,P62753,P61289,P30154,P49840,O43252,P49720,Q99956,O00459,P48556,Q15008,P27361,P60900,Q06323,Q99460,P28482,P07900,P26038,P36507,Q06124,O75832,O94979,P62195,P43686,Q9UNM6,P62993,P49841,Q13200,Q9Y490,O00231,O00487,P55036,P46940,P26641,P25788,O00232,P31939,O95429,P41240,Q14203,O00203,P18206,P11274,P25789,P42224,P49589,Q02750,P35269	72
Signaling by mapk mutants	0.8689060642092736	3.823678408574907	0.0001314753781263	0.1684568458563431	0.0010368977950623	2	P28482	1
Cell cycle checkpoints	0.3827014386827638	3.7902934231979217	0.0001504694288247	0.1903267379904678	0.001147329394789	134	P30153,P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,Q8NBT2,Q9UQ84,Q15691,P49736,P28070,P28066,Q7L590,P27694,P24941,P25786,Q13409,P49721,O60566,P50748,P63167,Q99436,Q14738,Q14204,O14818,P14635,Q9Y6G9,Q92530,P35998,P17980,P61289,P27348,P30154,P42771,P49720,Q9UJA3,P48556,Q15008,P60900,Q06323,Q8NFH4,Q99460,O43237,Q16763,P06493,Q04917,P61981,P15927,O75832,P61088,O96017,P62195,P43686,Q9UBD5,P43034,Q9UNM6,P54132,P51530,O00231,Q9P258,O00487,P55036,P25788,O00232,Q9Y266,Q13416,P40938,Q13200,P25789,P63104	73
Transcriptional regulation by runx1	0.458847222964959	3.6844836607250326	0.0002291667250207	0.2749812495564162	0.0015383775847084	69	P28072,P62191,P25787,P20618,P28074,P62333,P51665,Q99873,Q96J02,P28070,P28066,P25786,P49721,Q15291,Q99436,O14818,P35998,Q92530,P17931,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,Q06124,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	39
Abc transporter disorders	0.5413003169564405	3.644690116042187	0.0002677141761777	0.3131595636767515	0.0017717122131009	45	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	34
Response of eif2ak4 gcn2 to amino acid deficiency	0.440587282245175	3.642930020823004	0.0002695521384792	0.3149288854751149	0.0017755007055697	75	P18621,P62910,P42766,P25398,P62249,P05388,P08865,P62266,P62861,P62081,P62753,P62854,P35268,P62899,P39019,P62750,P62701,P15880,P62851,P60866,P30050,P46781,P46783,P62273,P05198,P46777,P08243,P46782,P62277,P63173,P23396,P62244,P61247,P62841,P62857,P27635,P62913,P62847,P62888,P08708,P46778,P61513,P62269,Q92616,P62906,P62829,P32969	47
Ethanol oxidation	0.9336901575973774	3.6341389254115137	0.0002789105550373	0.3238674141939033	0.0018200535289182	3	P30837,P05091	2
Signaling by nodal	0.8287752675386421	3.625259609554769	0.000288671312884	0.3330660877197594	0.0018493417898459	2	P28482	1
Signaling by activin	0.8287752675386421	3.625259609554769	0.000288671312884	0.3330660877197594	0.0018493417898459	2	P28482	1
Activation of the ap 1 family of transcription factors	0.8287752675386421	3.625259609554769	0.000288671312884	0.3330660877197594	0.0018493417898459	2	P28482	1
Er to golgi anterograde transport	0.4287689066740697	3.5264824642723616	0.0004211190514546	0.446201551066256	0.0025035170728429	76	P47755,P61923,P61163,P52907,Q13190,Q9NP61,Q92734,Q9NZ32,O15498,Q14746,Q9Y6G9,Q13885,Q9H9E3,P35606,O43237,O14579,O94979,P48444,P18085,Q9Y678,Q9UP83,P53621,Q9UJW0,O60763,Q14203,Q9BUF5,O15027	27
Copi mediated anterograde transport	0.4832487458916962	3.519598791154894	0.0004322000435648	0.454748289547727	0.0025356517124075	55	P47755,P61923,P61163,P52907,Q13190,Q9NP61,Q9NZ32,O15498,Q14746,Q13409,Q14204,P63167,Q9Y6G9,P53618,Q13885,Q9H9E3,P35606,O43237,Q9UBF2,O14579,P62820,P48444,P18085,Q9Y678,Q9UP83,P53621,Q9UJW0,Q92538,O60763,Q8N6T3,P04350,Q14203,Q9BUF5	33
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand	0.6075175754690199	3.514809135382764	0.0004400701491662	0.4607383084723339	0.0025619021546898	31	P31689,P47755,P31948,P61163,P52907,Q15185,Q9NZ32,Q13409,Q14204,Q9Y6G9,Q13885,Q02790,O43237,P07900,Q13451,P08238,P0DMV9,P11142,Q9UJW0,P04350,Q14203,Q9BUF5,O60884	23
Global genome nucleotide excision repair gg ner	0.5281036906029403	3.477907890243401	0.000505343543856	0.5079506171753059	0.0028821015936178	44	P18887,Q9UBW8,Q9UNS2,P27694,Q86WJ1,P09874,P49005,P32780,P12004,Q9NRF9,P61201,P56282,Q13098,P54727,P15927,P61088,Q9BT78,P40937,Q92905,Q99627,Q7L5N1,P18074,Q9H9Q2,P18858,P40938,P28340	26
Runx3 regulates p14 arf	0.7939952437574294	3.449168827946169	0.0005623150112568	0.5457692076880754	0.003168385384712	2	P25440	1
P130cas linkage to mapk signaling for integrins	0.7803210463733579	3.378841971039113	0.0007279183772666	0.6399964419809131	0.0039738112190857	2	P46108	1
Methionine salvage pathway	0.8762553871976463	3.373314888005915	0.0007426896546256	0.6473857924160515	0.004038734827286	3	Q13126	1
Prolactin receptor signaling	0.8722667815997769	3.3548776592818643	0.0007940009084574	0.671896365174939	0.0042196336157797	3	Q06124	1
Cellular responses to stimuli	0.2677290474675426	3.3491971283012645	0.0008104611036725	0.6793925995273806	0.0042908563337833	323	P00390,P28074,Q9UI12,P51665,P31948,Q06210,Q15185,P28070,P51858,P42766,P27694,P25398,P24941,Q15382,P21281,Q13409,P49721,Q99436,P63167,Q92530,P62861,P62258,P55072,P34932,P06400,P15880,Q15008,P27361,P30050,Q16763,P46777,P46782,Q13451,O75832,P62857,P62195,P04792,P55036,P30043,P25788,O00232,Q9BUF5,P25789,P32969,P28072,P20618,P61163,P52907,Q9NP61,Q9NZ32,Q9Y6G9,P11802,P17980,P21283,P42771,Q13885,Q0VDF9,P62851,P60900,P46783,Q99460,P62841,P62913,P62847,Q9UNM6,Q9Y490,P08708,O00487,O95429,O95817,P04350,Q9Y2L1,P62906,P62269,P62829,P31689,P25787,Q16881,P63208,P25786,Q14204,O14818,Q53FT3,P62081,P35268,P39019,P49720,P62750,P62701,P48556,P60866,Q15370,P28482,P30041,Q92598,P08243,P23396,P63173,O94979,P08238,O00231,Q99543,Q14203,O43242,P28066,P62191,P47755,P62333,Q9Y5K8,P05388,P08865,P35998,P62266,P62753,P61289,P49840,Q99615,Q13617,Q06323,Q8NFH4,Q02790,O43237,P05198,P07900,P62277,P15927,P62244,P61247,P43686,P0DMV9,P11142,P49841,P46778,Q9UJW0,Q92616,Q13200,O60884	137
Activation of ppargc1a pgc 1alpha by phosphorylation	0.7734839476813289	3.343440827538521	0.0008274633877816	0.6869560591483929	0.0043644027558556	2	P54646	1
Cellular response to starvation	0.4071615333532226	3.322099397710918	0.0008934286094941	0.7146505246035618	0.0046946829180535	88	Q9UI12,P18621,P62910,P42766,Q9Y5K8,P25398,P62249,P21281,Q15382,P05388,P08865,P62266,P62861,P62081,P21283,P62753,P62854,P35268,P62899,P39019,P62750,P62701,P15880,P62851,P60866,P30050,P46781,P46783,P62273,P05198,P46777,P08243,P46782,P63173,P23396,P62277,P62244,P61247,P62841,P62857,P27635,P62913,P62847,P62888,P08708,P61513,P62269,P46778,Q92616,P62906,P62829,P32969	52
Downregulation of erbb4 signaling	0.7669441141498183	3.309428716017768	0.0009348656814136	0.7307809789580146	0.004870068779508	2	P46934	1
Mapk1 erk2 activation	0.862027951234011	3.307350488002202	0.0009418297261916	0.7334010361182807	0.004870068779508	3	P28482,Q06124	2
Cilium assembly	0.4346492708712121	3.257126993207578	0.0011254606871833	0.7940064815660277	0.0056233631057731	63	P30153,P07437,Q13561,Q15019,Q7Z4H7,P61163,Q15691,Q9H6D7,P48643,P17987,A6NIH7,O43924,Q13409,P36405,Q14204,P63167,Q9BW83,O60645,P62258,Q9UPT5,Q9Y366,Q8TAG9,P17612,Q13885,P50991,P06493,P07900,P49368,P61981,Q15154,P18085,P43034,P23258,P78371,Q14008,Q92538,P50990,P04350,Q14203,Q9BUF5	40
Displacement of dna glycosylase by apex1	0.8498364555456221	3.2503828259006378	0.0011524975065664	0.8016825969261104	0.0057338794386975	3	P13051,P27695	2
Cooperation of prefoldin and tric cct in actin and tubulin folding	0.7464136614387974	3.220517843830637	0.0012795922656385	0.8341078722938784	0.0062771606597584	15	P40227,P50991,P78371,Q99471,P49368,Q9UHV9,P50990,P48643,Q99832,Q9BUF5,Q13885,P17987	12
M phase	0.3176471651957692	3.2035565584050496	0.001357413749446	0.8512882225180801	0.0066126787863641	196	P30153,P28072,P07437,P25787,P62191,Q14739,P28074,P20618,P62333,P51665,Q8NBT2,Q7Z4H7,P61163,Q15691,Q9H6D7,P28070,Q15003,Q9BPX3,Q96GX5,P25786,Q9UN37,P49721,Q15021,Q99436,Q14738,Q14204,Q9NTJ3,Q9Y6G9,Q92530,Q9HC35,P17980,Q6IBW4,P30154,O95347,P06400,Q13885,P49720,Q01105,Q15008,P27361,P60900,Q9Y3E7,Q06323,Q99460,Q9H444,Q16763,Q96CW5,P06493,P28482,O43237,P07900,O75832,Q9BSJ2,P63151,P62826,P62195,P43686,P43034,Q9UNM6,P23258,Q99986,Q9P258,O00487,P55036,P25788,O00232,O60763,P04350,Q14203,Q9Y266,Q9H8Y8,Q9BUF5,Q13200,P25789,O43242	75
Frs mediated fgfr3 signaling	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Pi 3k cascade fgfr2	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Activated ntrk2 signals through frs2 and frs3	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Met activates ptpn11	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Grb2 sos provides linkage to mapk signaling for integrins	0.7434601664684859	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q9Y490	1
Frs mediated fgfr4 signaling	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Pi 3k cascade fgfr1	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Pi 3k cascade fgfr4	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Stat5 activation downstream of flt3 itd mutants	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Signaling by flt3 itd and tkd mutants	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Frs mediated fgfr1 signaling	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Pi 3k cascade fgfr3	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Stat5 activation	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Frs mediated fgfr2 signaling	0.7434601664684829	3.186063751615265	0.0014422281291541	0.8679938286816048	0.0066560725829056	2	Q06124	1
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation	0.8356006585156165	3.1833370924572755	0.0014558801215973	0.8705017803178211	0.0066970485593478	3	P00374	1
Synthesis of diphthamide eef2	0.8311031816830181	3.1620363771803324	0.0015666999153944	0.8891750830472439	0.0071219913685694	3	Q9BQC3,Q9H2P9	2
Serine biosynthesis	0.7381093935790684	3.1576817176632788	0.0015902908580072	0.8927887474437541	0.0071564475944237	2	Q9Y617	1
Protein folding	0.5300096470682092	3.140165580671915	0.0016885236800103	0.9066128041511388	0.0073869499649331	36	O95302,P48643,Q99832,P17987,O75347,P61962,Q13885,P40227,P50991,Q15813,P49368,Q15477,P78371,Q99426,Q99471,P50990,Q9UHV9,P04350,Q9BUF5	19
Transport to the golgi and subsequent modification	0.3976277105776293	3.138980798608764	0.0016953655657223	0.9075064592835216	0.0073869499649331	80	P47755,P61923,P61163,P52907,Q13190,Q9NP61,Q92734,Q9NZ32,O15498,Q14746,Q9Y6G9,Q13885,Q9H9E3,P35606,O43237,O14579,O94979,P48444,P18085,Q9Y678,Q9UP83,P53621,Q9UJW0,O60763,Q14203,Q9BUF5,O15027	27
Galactose catabolism	0.7330558858501741	3.130781847167982	0.0017434161584115	0.9135464117355504	0.0075494224390475	2	P51570	1
Cytosolic trna aminoacylation	0.6215805401152433	3.1260554292685128	0.0017716815492503	0.9169135564761792	0.0076247521889516	23	P49591,P26639,P26640,Q9Y285,P54577,Q15046,P47897,P23381,P49588,P14868,Q9NSD9,Q9P2J5,O43776,Q15181,P07814,P41252,O43324,P54136,P49589,P41250	20
Activation of irf3 irf7 mediated by tbk1 ikk epsilon	0.7315695600475549	3.122852538726795	0.0017910746043794	0.9191476588209376	0.0076846411924903	2	Q06124	1
Membrane trafficking	0.2914472753458951	3.108821105900221	0.0018783541230185	0.9284822051033644	0.0080101241173099	262	Q9UNF0,P50395,P35579,Q13409,P63167,Q9BXS5,Q12981,P62258,P55327,Q14677,P53618,P20645,Q86X10,Q9UJY5,Q9H9E3,P54646,Q5VIR6,Q14C86,O14656,Q0IIM8,P82094,Q9Y678,Q01968,Q13492,P53621,Q9Y5X3,P52732,Q92538,O60763,Q8N6T3,Q9BUF5,Q99661,Q9UQN3,Q13561,Q8TD16,Q13439,P61163,Q2M2I8,P52907,P49257,Q9UNS2,Q12846,Q9NP61,Q9NZ32,Q99961,Q4KMP7,Q92734,Q9UN37,Q14746,O60749,Q9Y6G9,Q9UPT5,Q14247,P42566,Q07866,Q13885,O15145,Q13098,Q9Y3E7,Q92930,O60664,Q8TC07,Q9BT78,Q9UP83,Q15102,O14964,P04350,O00203,Q9UKS6,P54619,P53365,P63104,Q13190,Q9H0H5,Q9NVZ3,Q14204,O60645,P27348,Q9BRG1,Q9H444,P61981,O94979,Q99816,Q9NVG8,P18085,Q9Y3P9,P62993,Q7L5N1,O60343,Q9H3P7,Q14203,Q14964,P47755,Q86Y91,P61923,Q8N1B4,Q9UBC2,Q9UBW8,Q9NP79,Q9NRW7,P60520,O15498,P02792,P61201,Q8TAG9,P35606,O14976,Q8WUX9,O43237,Q9UBF2,O14579,P62820,Q04917,O75351,P31150,O75886,P48444,P11142,P43034,Q92905,Q99627,P50570,P33176,Q9H9H4,Q9H9Q2,Q9UJW0,Q86TI0,Q10567,O15027	129
G2 m dna replication checkpoint	0.7223543400713361	3.07351125095791	0.0021155571032429	0.9487618379272856	0.008886606634281	2	P06493	1
Nucleotide excision repair	0.4234178705894755	3.061223947877636	0.0022043415323689	0.9547749825232248	0.0092197110298845	60	P18887,Q9UBW8,Q9UNS2,Q86WJ1,P09874,P49005,P32780,P12004,Q9NRF9,P61201,P56282,P55199,Q13098,P54727,P23193,P61088,Q9BT78,Q9ULR0,Q92905,Q99627,Q7L5N1,P18074,Q9H9Q2,P18858,P40938,P28340	26
Hdl clearance	0.7199762187871532	3.060727534631078	0.0022079992202717	0.9550069814195548	0.0092197110298845	2	Q8WTV0	1
Separation of sister chromatids	0.3782160843265705	3.0583226012943143	0.0022257982029896	0.9561190678217386	0.0092664536462743	102	P30153,P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,Q8NBT2,Q15691,P28070,P25786,O60566,P49721,Q99436,Q14738,Q14204,O14818,Q9Y6G9,Q92530,P35998,P17980,P61289,P30154,P49720,Q13885,P48556,Q15008,P60900,Q06323,Q99460,O43237,Q16763,O75832,P62195,P43686,P43034,Q9UNM6,O00231,Q9P258,O00487,P55036,P25788,O00232,P04350,Q9Y266,Q9BUF5,Q13200,P25789,P28066	51
Hiv infection	0.3348584505451818	3.0155211755140683	0.0025653802510643	0.9727813559651598	0.0105917583458008	141	P28072,O43242,P25787,P62191,P20618,P28074,Q8WUM4,P62333,P51665,Q9NP79,P28070,P63208,P28066,P25786,Q9UN37,P49721,Q99436,Q9BXS5,O14818,P32780,P35998,Q92530,Q00403,P17980,P61289,P49720,P55199,P48556,Q15008,P60900,Q9Y3E7,Q15370,Q06323,Q8NFH4,Q8WUX9,Q99460,Q9H444,Q12962,P23193,Q13177,O75832,Q99816,P62826,P62195,P43686,Q96PU5,P43487,Q9UNM6,Q8IXH7,O00231,O00487,P55036,P18074,P25788,O00232,P18858,Q9H9H4,Q10567,P13010,Q9H3P2,Q13200,P25789,P52294,P35269,P39748	65
Resolution of abasic sites ap sites	0.5656839188972576	2.9952198334678504	0.0027424711076191	0.9787834282296124	0.0111527158376512	27	P18887,P09874,P49005,P12004,P27695,P18858,Q9NRF9,Q9NX46,P15927,P40938,P56282,P27694,P13051,P28340,P29372,P40937,P39748	17
Vesicle mediated transport	0.2829549826988042	2.993366865677281	0.0027591786005807	0.9792763141084116	0.011188229990216	270	Q9UNF0,P50395,P35579,Q8WTV0,Q13409,P63167,Q9BXS5,Q12981,P62258,P55327,Q14677,P53618,P20645,Q86X10,Q9UJY5,Q9H9E3,P54646,Q5VIR6,Q14C86,O14656,Q0IIM8,P82094,Q9Y678,Q01968,Q13492,P53621,Q9Y5X3,P52732,Q92538,O60763,Q8N6T3,Q9BUF5,Q99661,Q9UQN3,Q13561,Q8TD16,Q13439,P61163,Q2M2I8,P52907,P49257,Q9UNS2,Q12846,Q9NP61,Q9NZ32,Q99961,Q4KMP7,Q92734,Q9UN37,Q14746,O60749,Q9Y6G9,Q9UPT5,Q14247,P42566,Q07866,Q13885,O15145,Q13098,Q9Y3E7,Q92930,O60664,Q8TC07,Q9BT78,Q9UP83,Q15102,O14964,P04350,O00203,Q9UKS6,P54619,P53365,P63104,Q13190,Q9H0H5,Q9NVZ3,Q14204,O60645,P27348,Q9BRG1,Q9H444,Q92598,P61981,O94979,Q99816,Q9NVG8,P18085,Q9Y3P9,P62993,Q7L5N1,O60343,Q9H3P7,Q14203,Q14964,P47755,Q86Y91,P61923,Q8N1B4,Q9UBC2,Q9UBW8,Q9NP79,Q9NRW7,P60520,O15498,P02792,P61201,Q8TAG9,P35606,O14976,Q8WUX9,O43237,Q9UBF2,O14579,P07900,P62820,Q04917,O75351,P31150,O75886,P48444,P11142,P43034,Q92905,Q99627,P50570,P33176,Q9H9H4,Q9H9Q2,Q9UJW0,Q86TI0,Q10567,O15027	132
Pp2a mediated dephosphorylation of key metabolic factors	0.7948260481712781	2.988086619685399	0.0028072997903931	0.9806329178085752	0.0112532617312046	3	P30153,Q14738	2
Fructose metabolism	0.7060047562425601	2.9852005185286083	0.0028339248611422	0.981345000228364	0.011264175317149	2	Q00796	1
Maturation of sars cov 1 nucleoprotein	0.7051129607609935	2.980354946636791	0.0028791455828633	0.9824949787083234	0.0114108509964896	2	P49840	1
Pd 1 signaling	0.7024375743162818	2.9658003238093165	0.0030189642667717	0.9856213863041614	0.0119312869472696	2	Q06124	1
Ionotropic activity of kainate receptors	0.6976813317479134	2.939858900744935	0.0032836173987078	0.990092819504926	0.0128326328980142	2	Q12959	1
Nrcam interactions	0.6976813317479134	2.939858900744935	0.0032836173987078	0.990092819504926	0.0128326328980142	2	Q12959	1
Copi independent golgi to er retrograde traffic	0.5393768345485969	2.892353122817461	0.0038236791813572	0.9953686385651191	0.0143823643202259	29	Q15102,Q8TD16,P47755,O43237,Q9Y6G9,Q9UJW0,P61163,P52907,P04350,Q14203,Q9BUF5,Q13885,Q9NZ32,P43034	14
Ptk6 regulates cell cycle	0.6887633769322177	2.8909877362791385	0.0038403310614483	0.9954759916065004	0.0144063756128662	2	P11802	1
Ticam1 rip1 mediated ikk complex recruitment	0.8621067034046607	2.8899531369425544	0.0038529925984978	0.9955559519653092	0.0144077047212331	4	Q13546	1
Formation of tubulin folding intermediates by cct tric	0.7476679931740344	2.889282205507793	0.0038612237884416	0.995607174660561	0.0144077047212331	12	P40227,P50991,P78371,P49368,P50990,P48643,Q99832,Q9BUF5,Q13885,P17987	10
Diseases of mismatch repair mmr	0.7713351174546463	2.8733719425020223	0.004061156818492	0.9966853534169072	0.0150337810457634	3	P20585,P52701	2
Uptake and function of anthrax toxins	0.7701457032411403	2.8675193034335007	0.0041370356619907	0.997021395771048	0.0152743711415079	3	P36507,Q02750	2
Recruitment of mitotic centrosome proteins and complexes	0.5124273721110509	2.8490116064766604	0.0043855280571014	0.9979012792550784	0.0160231663127951	33	P30153,P07437,Q13561,Q7Z4H7,P61163,Q15691,Q9H6D7,Q13409,Q14204,P63167,P62258,P17612,O94927,Q96CW5,P06493,P07900,P61981,Q15154,Q9BSJ2,P43034,P23258,Q14008,P04350,Q14203	24
Tie2 signaling	0.7648708737694221	2.8415119885884006	0.0044900163752823	0.9981886409588888	0.0163623194143406	3	O00459	1
E2f mediated regulation of dna replication	0.7131101934419021	2.82194288800283	0.0047733677097967	0.9987850710105192	0.0172156092959999	13	Q14181,P30153,P09884,P06493,P49643,Q13416,P30154,P06400,Q9UJA3,P49642	10
Estrogen dependent nuclear events downstream of esr membrane signaling	0.7536622140782749	2.785965139403473	0.0053368610807038	0.999451140271692	0.0186723593422132	3	P28482	1
Phenylalanine metabolism	0.6676575505350706	2.7741102553855383	0.0055352914915296	0.9995851473596696	0.0192705061107099	2	Q7L266	1
Mitotic metaphase and anaphase	0.3221938037852586	2.7695265600992096	0.0056137827010531	0.999628635938378	0.019495388934598	135	P30153,P28072,O43242,P25787,P62191,Q14739,P28074,P20618,P62333,P51665,Q8NBT2,Q15691,P28070,P25786,Q9UN37,O60566,P49721,Q99436,Q14738,Q14204,O14818,P14635,Q9Y6G9,Q92530,P35998,P17980,P61289,P30154,P49720,Q13885,P48556,Q15008,P60900,Q9Y3E7,Q06323,Q8NFH4,Q99460,Q9H444,Q16763,P06493,O43237,O75832,P63151,P62826,P62195,P43686,P43034,Q9UNM6,Q99986,O00231,Q9P258,O00487,P55036,P25788,O00232,P04350,Q9Y266,Q9BUF5,Q13200,P25789,P28066	61
Base excision repair	0.5119311627707532	2.7531208114036256	0.0059030108369413	0.9997530846449888	0.020348708118498	31	P18887,P09874,P49005,P12004,P27695,P18858,Q9NRF9,Q9NX46,P15927,P40938,P56282,P27694,P13051,P28340,P29372,P40937,P39748	17
Regulation of plk1 activity at g2 m transition	0.4816593812616982	2.750541786010285	0.0059496802774963	0.99976882430485	0.0204593172287434	37	P30153,P07437,Q13561,Q7Z4H7,P61163,Q15691,Q9H6D7,P63208,Q13409,Q14204,P63167,P14635,O14974,P62258,P17612,O94927,P06493,P07900,P61981,Q15154,P43034,O14965,P23258,Q14008,P04350,Q14203	26
Negative feedback regulation of mapk pathway	0.8292682926829353	2.74312173418913	0.0060858119534654	0.999809237545437	0.0207746816805646	4	P36507,P28482,Q02750	3
Mapk3 erk1 activation	0.8292682926829357	2.74312173418913	0.0060858119534654	0.999809237545437	0.0207746816805646	4	P06493,Q06124,Q02750	3
Signal attenuation	0.743681236990771	2.736175800507086	0.0062157809230831	0.9998412145406632	0.0210088638564525	3	P27361,P28482	2
Aggrephagy	0.6576074225797567	2.707909468536726	0.0067708489342948	0.9999274915031904	0.022510666006672	15	Q13409,Q14204,P63167,O43237,Q9Y6G9,Q99497,P07900,P04350,P61088,Q9BUF5,Q13885	11
Anchoring of the basal body to the plasma membrane	0.4991299415168853	2.6896073788268744	0.0071536128339921	0.999957778864384	0.023671034920026	32	P30153,P07437,Q13561,Q15019,Q7Z4H7,P61163,Q15691,Q9H6D7,Q13409,Q14204,P63167,P62258,P17612,O94927,P06493,P07900,P61981,Q15154,P43034,P23258,Q14008,P04350,Q14203	23
Raf independent mapk1 3 activation	0.8300089312295407	2.6825890869171247	0.0073054691363241	0.999965933481324	0.0240143345937277	7	P06493,P28482,P36507,Q06124,Q99956,Q02750	6
Antigen processing cross presentation	0.4071957895148521	2.681161520707484	0.0073367094049143	0.9999674049088924	0.0240143345937277	55	P28072,P62191,P06756,P25787,P20618,P28074,P09429,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Response of eif2ak1 hri to heme deficiency	0.7273178680426859	2.6538760083075985	0.007957306036644	0.99998644500574	0.0256645985503714	3	P08243	1
Other interleukin signaling	0.7262121663141534	2.648284530904587	0.0080901402756241	0.9999887667158104	0.0259736082533196	3	P40222	1
Recruitment of numa to mitotic centrosomes	0.472614842750906	2.6333900559474768	0.008453720029026	0.9999932837897276	0.0268929690702122	36	P30153,P07437,Q13561,Q7Z4H7,P61163,Q15691,Q9H6D7,Q13409,Q14204,P63167,P62258,P17612,Q13885,O94927,Q96CW5,P06493,P07900,P61981,Q15154,Q9BSJ2,P43034,P23258,Q14008,P04350,Q14203,Q9BUF5	26
Abc family proteins mediated transport	0.3969708578477622	2.6019843477281404	0.0092686082360013	0.9999978808514288	0.0288333865966961	56	P28072,P62191,P25787,P20618,P28074,P62333,P51665,P28070,P28066,P25786,P49721,Q99436,O14818,O15439,P35998,Q92530,P17980,P49720,P48556,Q15008,P60900,Q06323,Q99460,P05198,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,O43242	36
Folding of actin by cct tric	0.7808219178082252	2.5908115608798425	0.0095749905442554	0.9999986268992744	0.0295896734220053	8	P40227,P50991,P49368,P50990,P48643,Q99832,P17987	7
Gluconeogenesis	0.5804257043545692	2.574146191459957	0.0100487803786284	0.9999992982952312	0.0307155530963305	20	P04075,P06733,P04406,P09104,P09972,P17174,P06744,P60174,P18669	9
Telomere c strand lagging strand synthesis	0.5426973926433063	2.56575798605334	0.0102950630850777	0.9999995050646	0.0311964870591017	23	Q14181,P09884,P54132,P51530,P49005,P12004,P18858,Q8WVB6,P49643,P15927,P40938,P27694,P28340,P49642,P39748	15
Synthesis of udp n acetyl glucosamine	0.7079988105857701	2.5556235298451844	0.0105997730082154	0.999999678690217	0.0320506067468239	3	Q06210,Q16222	2
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components	0.6263376932223463	2.540229398463138	0.0110779781835239	0.999999836937736	0.0332102636570173	2	Q15404	1
Smad2 smad3 smad4 heterotrimer regulates transcription	0.7028851263876725	2.5294177908571016	0.011425193590637	0.9999999003717868	0.0340796535075614	3	P28482	1
Gab1 signalosome	0.702646446625039	2.528192605387731	0.0114651435891439	0.9999999058634288	0.0340796535075614	3	P62993,Q06124	2
Inhibition of replication initiation of damaged dna by rb1 e2f1	0.7957725513545755	2.5259482070745434	0.0115386490801592	0.999999915189578	0.0342146654460164	7	Q14181,P30153,P09884,P49643,P06400,P49642	6
Dna repair	0.3303651937710932	2.513774209900359	0.0119446879950806	0.9999999523454814	0.0352808363307329	116	P18887,P43246,Q04323,Q16658,Q9UQ84,P53041,Q9UBW8,Q9UNS2,P13051,Q9NY27,Q86WJ1,P09874,P49005,P32780,P12004,Q9NRF9,Q8TAT6,P61201,P56282,P55199,Q14694,Q13098,P54727,P52701,P27695,P23193,P15927,P61088,Q9BT78,O96017,Q9ULR0,Q92905,Q7L5N1,Q99627,P54132,P18074,P20585,P18858,Q9H9Q2,Q9NX46,P13010,P40938,Q14258,P28340,P29372,P39748	46
Aryl hydrocarbon receptor signalling	0.6995472504087918	2.5122673423696256	0.0119958174491496	0.999999955682761	0.0353119255345792	3	P08238	1
Endosomal sorting complex required for transport escrt	0.6413966643103259	2.5101194928156594	0.0120690313928202	0.999999960058992	0.0354243745693028	14	Q9Y3E7,Q9BRG1,Q8WUX9,Q9H444,O14964,Q9H9H4,O75351,Q9NP79,Q99816,Q9UN37	10
Resolution of ap sites via the multiple nucleotide patch replacement pathway	0.5471922812426606	2.5088743477238573	0.0121116558812917	0.9999999624050576	0.0354752676439504	22	P09874,P49005,P12004,P27695,P18858,Q9NRF9,Q9NX46,P15927,P40938,P56282,P27694,P28340,P40937,P39748	14
Interleukin receptor shc signaling	0.6971498517231258	2.4999271891918173	0.012421883383326	0.999999975803332	0.0363081299725134	3	O00459	1
Interleukin 12 signaling	0.5020510739076434	2.4985169858753222	0.012471416562418	0.9999999774475432	0.0363771256487993	27	P05388,P26038,P52907,P23528,Q53EL6,Q13177,Q13126,P14174,P37837,P17987,O00170	11
Aurka activation by tpx2	0.4688978735539123	2.472836052056961	0.0134045621079057	0.99999999401366	0.038856612887173	33	P30153,P07437,Q13561,Q7Z4H7,P61163,Q15691,Q9H6D7,Q13409,Q14204,P63167,P62258,P17612,O94927,O75330,P06493,P07900,P61981,Q15154,P43034,O14965,P23258,Q14008,P04350,Q14203	24
Uptake and function of diphtheria toxin	0.7679952409280243	2.4618426389104004	0.0138225297891056	0.999999996696514	0.0399855861734336	4	P13639,P07900,P08238	3
Dna strand elongation	0.4816292877923077	2.4587979458271585	0.0139403050229425	0.9999999972061696	0.0402433085333093	30	Q14181,P09884,P51530,Q9BRX5,P49005,P12004,P18858,P49736,P49643,P15927,P40938,Q9Y248,P27694,P28340,Q9UJA3,P49642,Q9BRT9,P39748	18
Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects	0.6889681831697835	2.4576748645956337	0.013983971342566	0.9999999973744712	0.0402864718554828	3	P06400,P11802	2
Gene and protein expression by jak stat signaling after interleukin 12 stimulation	0.5093077966416157	2.4544321237565794	0.0141107300906111	0.9999999978077992	0.0405615600153051	25	P05388,P26038,P52907,P23528,Q53EL6,Q13177,Q13126,P14174,P37837,P17987,O00170	11
Nef and signal transduction	0.6108799048751401	2.4509758867416167	0.0142469497034269	0.9999999981941328	0.0405615600153051	2	Q13177	1
Dscam interactions	0.6108799048751401	2.4509758867416167	0.0142469497034269	0.9999999981941328	0.0405615600153051	2	Q16512	1
Activated ntrk2 signals through cdk5	0.6108799048751401	2.4509758867416167	0.0142469497034269	0.9999999981941328	0.0405615600153051	2	Q00535	1
Transcription coupled nucleotide excision repair tc ner	0.401930464486183	2.4508579521126	0.0142516182241361	0.999999998206092	0.0405615600153051	50	P18887,Q9UBW8,Q9UNS2,P27694,P49005,P32780,P12004,Q9NRF9,P61201,P56282,P55199,Q13098,P15927,P23193,Q9BT78,P40937,Q9ULR0,Q92905,Q99627,Q7L5N1,P18074,Q9H9Q2,P18858,P40938,P28340	25
Biological oxidations	0.419362143189722	2.4508250312582818	0.0142529216589775	0.999999998209417	0.0405615600153051	45	P48506,P07099,P05091,Q15185,Q9HBK9,P31153,O95861,P23526,P10768,O75223,P21266,O43252,Q8WUX2,Q96KP4,P78417,Q96DG6,Q99707,P08238,Q9NZL9,O00170,P11766,P14550,O60701,P30837,P28161	25
Wnt mediated activation of dvl	0.6105826397146169	2.449249987026491	0.0143154053701102	0.9999999983617868	0.0406569103932482	2	P19784	1
Tp53 regulates transcription of genes involved in cytochrome c release	0.7624173196781995	2.43575551275272	0.0148607249734868	0.999999999246332	0.0419508996736461	4	Q13625	1
Negative regulation of mapk pathway	0.6635184495891169	2.431414462161392	0.0150399991302738	0.9999999994161684	0.0422022375595484	12	P30153,P27361,Q14738,P28482,P53041,P36507,Q99956,Q02750,P30086	9
Golgi to er retrograde transport	0.3534768017493369	2.4219925806629212	0.0154356656845999	0.999999999667745	0.04309039784193	72	Q13561,Q8TD16,P47755,Q86Y91,P61923,P61163,P52907,Q9H0H5,Q9NP61,Q9NZ32,Q13409,Q14204,P63167,Q9Y6G9,Q12981,P53618,Q07866,Q13885,P35606,O43237,Q9UBF2,O14579,P62820,P48444,P18085,Q9Y678,P43034,Q15102,P53621,P52732,Q9UJW0,Q92538,P33176,Q8N6T3,P04350,Q14203,Q9BUF5,Q99661	38
Hsf1 activation	0.642361071769846	2.421686770537943	0.0154486600958594	0.9999999996738408	0.04309039784193	13	P04792,Q02790,Q92598,P07900,P62258,Q15185,P15927,P27694,P08238,P0DMV9	10
Budding and maturation of hiv virion	0.6420013702034243	2.4196041791805354	0.0155374093931306	0.9999999997125896	0.043138653290818	13	Q9Y3E7,Q8WUX9,Q8WUM4,Q9H444,Q9H9H4,Q9NP79,Q99816,Q96PU5,Q9UN37	9
Lagging strand synthesis	0.5683934159713799	2.4165156180078884	0.0156698539817443	0.9999999997620296	0.0433625347857738	19	Q14181,P09884,P51530,P49005,P12004,P18858,P49643,P15927,P40938,P27694,P28340,P49642,P39748	13
Processive synthesis on the lagging strand	0.6244979856695348	2.40980393094459	0.0159610956144304	0.9999999998428868	0.0440815298170196	14	Q14181,P09884,P51530,P49005,P12004,P18858,P49643,P15927,P28340,P49642,P39748	11
Interleukin 12 family signaling	0.4750666041067639	2.403288213134939	0.0162483757397653	0.9999999998956952	0.0447867802807284	30	P05388,P78417,P52907,P23528,P26038,Q53EL6,Q13177,Q13126,P14174,P37837,Q9H3K6,P17987,O00170	13
Erks are inactivated	0.7955357142857148	2.400324561341632	0.0163805407120811	0.9999999999136152	0.0450625463118625	6	P30153,P27361,Q14738,P28482,P51452	5
Association of tric cct with target proteins during biosynthesis	0.5543644629160356	2.3960353934311875	0.0165734898693301	0.9999999999344004	0.0455041218917225	20	P40227,P50991,P49368,O95302,P50990,P48643,Q99832,P61962,P17987,Q15477	10
Met activates ras signaling	0.6764793339280453	2.392764345618209	0.0167219774071889	0.9999999999469243	0.0458100052419983	3	P62993,Q96P70	2
Tgf beta receptor signaling activates smads	0.6937619928273888	2.3921454806440945	0.0167502014890557	0.9999999999490194	0.0458100052419983	10	P61081,Q9UNE7,P62942,Q9Y5K5,Q96PU5	5
Dna damage recognition in gg ner	0.5518009162788766	2.3783299233876227	0.0173912576494061	0.999999999979582	0.0472866947327846	20	Q99627,Q7L5N1,P09874,Q9H9Q2,Q9UBW8,Q9UNS2,Q9BT78,Q13098,P54727,Q92905	10
Gp1b ix v activation signalling	0.5954221165279339	2.3607528915106784	0.0182378786486419	0.9999999999939074	0.0493020110675233	2	P63104	1
Activation of rac1 downstream of nmdars	0.5939357907253179	2.3520263768063625	0.018671450866849	0.9999999999967216	0.05037701070421	2	P63000	1
Intra golgi and retrograde golgi to er traffic	0.3326485618175679	2.349511384596994	0.0187980692441884	0.9999999999972644	0.0505627009298588	100	Q13561,Q8TD16,P47755,Q86Y91,P61923,Q8N1B4,P61163,P52907,Q13190,Q9NRW7,Q9H0H5,Q9NP61,Q9NZ32,O15498,Q13409,Q14746,P63167,Q14204,Q9Y6G9,Q12981,P53618,P20645,Q13885,Q9H9E3,P35606,O60664,O43237,Q9UBF2,O14579,Q5VIR6,P62820,P82094,P48444,Q9Y678,P18085,P43034,Q9UP83,Q15102,P53621,P52732,Q92538,P33176,Q9UJW0,Q8N6T3,P04350,Q14203,Q14964,Q9BUF5,Q99661,P53365	50
Synthesis of ip2 ip and ins in the cytosol	0.6672613737733976	2.3445321090934037	0.0190509700760612	0.9999999999980947	0.0510586556646149	3	P29218,Q9NPH2	2
Nucleotide biosynthesis	0.6450208426269731	2.3274513997662183	0.0199412528025333	0.999999999999467	0.0530883826982054	12	P22102,P30566,P31939,O15067,P22234,P12268,P49915,Q06203,P11172,P30520	10
Runx2 regulates osteoblast differentiation	0.738299944379905	2.3220295147604393	0.0202313464422303	0.9999999999996482	0.053758672459184	4	P06400,P28482	2
Pentose phosphate pathway	0.7518608740192096	2.320710559504232	0.0203024704378109	0.9999999999996824	0.0538456824654986	7	P52209,P29401,P11908,P37837	4
Activation of the pre replicative complex	0.5071418611860533	2.301526191678095	0.021361906677336	0.9999999999999304	0.0559155878139971	23	Q9NR33,P49736,Q7L590,P27694,P24941,P33992,P09884,Q9NRF9,P56282,Q9UJA3,Q14181,P33991,P49643,P15927,Q9UBD5,Q07864,P25205,Q13416,P49642	19
Deadenylation dependent mrna decay	0.4252306580530941	2.292991556298652	0.0218484910798433	0.9999999999999654	0.0568709331818556	39	Q6P2E9,Q96F86,Q96C86,Q04637,P60842,Q9GZS3,Q6PGP7,Q86TB9,Q14240,P26196,P11940,Q9Y2L1,P06730,Q9HBH5,Q8IZD4,Q15477,Q9Y450	17
Translesion synthesis by y family dna polymerases bypasses lesions on dna template	0.5278483561043846	2.28749018920851	0.022167227430883	0.999999999999978	0.0575937408991276	21	P49005,P12004,Q9NRF9,Q8TAT6,P55072,P15927,P40938,P56282,P27694,P28340,Q14258,Q14694,P40937	13
Map2k and mapk activation	0.6525701952895786	2.267631091900974	0.0233517009902182	0.999999999999996	0.0601145623656443	11	P27361,Q9Y490,P46940,P28482,P36507,P18206,Q02750,P30086	8
Signaling by fgfr4 in disease	0.5793697978596813	2.2660308207571833	0.0234494962546965	0.9999999999999966	0.0602557568595955	2	P62993	1
Small interfering rna sirna biogenesis	0.7239738251041237	2.253757228646301	0.0242114449125017	0.9999999999999988	0.0619335375363657	4	Q15631,Q9UPY3,Q99598	3
Synthesis of active ubiquitin roles of e1 and e2 enzymes	0.6847229768911173	2.2529423060887073	0.024262786919168	0.9999999999999988	0.0619335375363657	9	P45974,P22314,Q16763,P61086,P68036,A0AVT1	6
Polb dependent long patch base excision repair	0.7629265771220706	2.2521245574880457	0.0243144018137444	0.999999999999999	0.0619335375363657	6	P27695,P18858,Q9NX46	3
Condensation of prophase chromosomes	0.6317255147701138	2.251986109798101	0.0243231498093638	0.999999999999999	0.0619335375363657	12	Q9NTJ3,P06493,Q6IBW4,O95347,P06400,Q01105	6
Urea cycle	0.5758026159334033	2.244839228254946	0.0247784554384535	0.9999999999999994	0.0628646889333641	2	Q9Y619	1
Coenzyme a biosynthesis	0.6452572108236747	2.228291387065136	0.0258610903189138	1.0	0.0650234941172689	3	Q13057,Q96CD2	2
Ptk6 regulates rho gtpases ras gtpase and map kinases	0.7183115860212177	2.2266263711893743	0.0259722549775434	1.0	0.0651861784141205	4	P46108	1
Activation of kainate receptors upon glutamate binding	0.6446625037169249	2.2251281640228173	0.0260726355474729	1.0	0.0653212637019724	3	Q15334,Q12959	2
Mismatch repair	0.6243185588441059	2.209676555775665	0.0271276179538446	1.0	0.0676492534060434	12	P43246,P49005,P12004,P20585,P52701,Q9UQ84,P18858,P15927,P28340	9
Interleukin 20 family signaling	0.6417095704377943	2.2094048644131123	0.0271464929918763	1.0	0.0676492534060434	3	Q06124	1
Cdc6 association with the orc origin complex	0.7116375272985871	2.1945407693274226	0.0281965563602697	1.0	0.0698935840520467	4	Q9UJA3,Q13416	2
Pcna dependent long patch base excision repair	0.535054573201003	2.1898098981709935	0.0285380265867578	1.0	0.0705372489165972	19	P49005,P12004,P27695,P18858,Q9NRF9,P15927,P40938,P56282,P27694,P28340,P40937,P39748	12
Protein ubiquitination	0.4751733154832707	2.1858872205316264	0.0288238574322989	1.0	0.0710718312434366	25	P45974,P22314,P12004,Q9GZS3,Q16763,Q5VTR2,P61086,Q14527,P68036,P61088,O75150,Q92541	12
Late endosomal microautophagy	0.6370600458822591	2.181833206348791	0.0291218448723287	1.0	0.0716806111506617	11	Q9Y3E7,Q8WUX9,Q9H444,O60664,Q9H9H4,Q99497,Q99816,P11142	8
Dual incision in gg ner	0.474152769605258	2.1777488696578913	0.0294247384114032	1.0	0.0722993134697001	25	Q86WJ1,P09874,P49005,P32780,P12004,P18074,Q9NRF9,P15927,P40938,P56282,P27694,P28340,P40937	13
Lipophagy	0.7070196311719337	2.172272898738614	0.0298350849468729	1.0	0.0727976072703699	4	O60664,P54646,P54619	3
G1 s specific transcription	0.617666871184059	2.171519446373824	0.0298919287971939	1.0	0.0728096807334428	12	P09884,P00374,P06493,P31350,P04818	5
Interleukin 21 signaling	0.5630202140309053	2.1684796156573096	0.0301222139188506	1.0	0.0729904423629489	2	P42224	1
Interleukin 15 signaling	0.5630202140309053	2.1684796156573096	0.0301222139188506	1.0	0.0729904423629489	2	P62993	1
Interleukin 9 signaling	0.5630202140309053	2.1684796156573096	0.0301222139188506	1.0	0.0729904423629489	2	P42224	1
Traf6 mediated induction of tak1 complex within tlr4 complex	0.5627229488703822	2.166695965649551	0.0302580444253055	1.0	0.0731931660839718	2	Q6SZW1	1
Phase i functionalization of compounds	0.5691151787861052	2.165121839891574	0.0303783558592529	1.0	0.0733577164725162	15	P11766,P07099,P05091,P08238,P30837	5
Dna damage bypass	0.4774611775357435	2.16160191417863	0.0306488737960277	1.0	0.0738837971405961	24	P49005,P12004,Q9NRF9,Q8TAT6,P55072,P15927,P40938,P56282,P27694,P28340,Q14258,Q14694,P40937	13
Formation of incision complex in gg ner	0.5595144337628388	2.159603368925212	0.0308033874074193	1.0	0.0739259176611266	16	P18074,Q86WJ1,P54727,P61088	4
Assembly of the hiv virion	0.63226424390541	2.1589249727940834	0.0308559880964622	1.0	0.0739259176611266	3	Q9H9H4	1
Downstream signaling of activated fgfr4	0.6319606016523729	2.157297465632975	0.0309824943583338	1.0	0.0739259176611266	3	Q06124	1
Downstream signaling of activated fgfr3	0.6319606016523729	2.157297465632975	0.0309824943583338	1.0	0.0739259176611266	3	Q06124	1
Downstream signaling of activated fgfr1	0.6319606016523729	2.157297465632975	0.0309824943583338	1.0	0.0739259176611266	3	Q06124	1
Downstream signaling of activated fgfr2	0.6319606016523729	2.157297465632975	0.0309824943583338	1.0	0.0739259176611266	3	Q06124	1
Signaling by ntrks	0.4325996875912533	2.148280215180058	0.0316915016449783	1.0	0.0754892645295494	33	P30153,P27361,Q14738,P46109,O00459,P28482,Q07812,P46108,P36507,P30154,Q06124,P51452,Q02750	13
Formation of xylulose 5 phosphate	0.6292001189414032	2.1424879965702903	0.0321542335647517	1.0	0.0764616774429605	3	Q00796,P14550	2
Post chaperonin tubulin folding pathway	0.6625902104730993	2.1374560042615176	0.0325609204690438	1.0	0.077037051295225	9	Q99426,P04350,Q9BUF5,Q13885,O75347	5
Potential therapeutics for sars	0.4177556518590579	2.1242709362878696	0.0336474945528673	1.0	0.0793402266515509	36	Q99720,P07437,Q02790,Q13546,P62942,P08238	6
Interleukin 23 signaling	0.5546967895362563	2.1184033753928713	0.0341409202625333	1.0	0.0803686428327756	2	P40763	1
Cyclin a b1 b2 associated events during g2 m transition	0.6576428226744355	2.1114465443203954	0.0347339480171944	1.0	0.0816183626718439	9	P30153,P14635,P06493,P63151,Q9Y570,P30154	6
Fcgamma receptor fcgr dependent phagocytosis	0.4154992972101882	2.102835764011185	0.0354801285520274	1.0	0.0830602778045846	36	O43865,P35240,Q9Y6W5,P27361,P62993,O15143,Q9UQB8,P28482,P07900,P23528,Q96F07,P46108,Q16512,P08238,Q96JJ3,O00459	16
Irs mediated signalling	0.6925956404175388	2.1023669364619857	0.0355211451765864	1.0	0.0830602778045846	4	O00459	1
Negative regulation of flt3	0.5511296076099776	2.0968573571486133	0.0360062043664055	1.0	0.0836927898099432	2	P41240	1
Downstream signal transduction	0.6799700159540982	2.095241177306245	0.0361495585351572	1.0	0.0836927898099432	8	P62993,P46109,P46108,Q06124,O00459	5
Signaling by pdgf	0.6799700159540982	2.095241177306245	0.0361495585351572	1.0	0.0836927898099432	8	P62993,P46109,P46108,Q06124,O00459	5
Purine ribonucleoside monophosphate biosynthesis	0.6532618409293803	2.0883561280495124	0.0367657218675674	1.0	0.0849790902474417	9	P22102,P30566,P31939,O15067,P22234,P49915,P12268,P30520	8
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex	0.6494905460472435	2.0684352511013886	0.0385991132951901	1.0	0.0886326611344546	9	P14635,P06493,Q04917,P61981,P27348,O96017,P63104	7
Polymerase switching	0.5677754114781888	2.064902372369548	0.0389322385907515	1.0	0.0892515208216085	14	Q14181,P09884,P49005,P12004,P49643,P49642	6
Signaling by moderate kinase activity braf mutants	0.5989963881015903	2.063609371741256	0.0390547683075359	1.0	0.0893863620480798	12	P27361,Q9Y490,P46940,P28482,P36507,P18206,Q02750,P30086	8
Enos activation	0.6139201382112993	2.0600790204525112	0.0393909871455058	1.0	0.0898865017981293	3	P07900	1
Gap filling dna repair synthesis and ligation in gg ner	0.5163000656331106	2.0599698363979213	0.0394014245230573	1.0	0.0898865017981293	19	P18887,P49005,P12004,P18858,Q9NRF9,P15927,P40938,P56282,P27694,P28340,P40937	11
Map3k8 tpl2 dependent mapk1 3 activation	0.7436642663454547	2.0518585633849353	0.0401834098661628	1.0	0.0910948966156753	5	Q02750	1
Gap junction assembly	0.6814501511997602	2.0479880849674967	0.0405611669029317	1.0	0.0911976236615597	4	Q13885,Q9BUF5	2
Transport of connexons to the plasma membrane	0.6814501511997602	2.0479880849674967	0.0405611669029317	1.0	0.0911976236615597	4	Q13885,Q9BUF5	2
Ikk complex recruitment mediated by rip1	0.7424898253913197	2.046560848101153	0.0407012223143699	1.0	0.0913661038512975	5	Q13546	1
Golgi cisternae pericentriolar stack reorganization	0.6119918726653985	2.041518828600194	0.0411992843101551	1.0	0.0923318144991666	11	P27361,P14635,P06493,P28482,O60763,Q9H8Y8	6
Carnitine metabolism	0.7168458116495949	2.0384610322616683	0.0415038479933924	1.0	0.0927227686858752	6	P23786	1
Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants	0.6774898159303941	2.028590438951601	0.0425000232067982	1.0	0.0946502050723391	4	P62993,O00459	2
Akt phosphorylates targets in the cytosol	0.6068986024383028	2.0219654970551844	0.0431799164402861	1.0	0.0958566815913315	3	P49841,P49840	2
Attenuation phase	0.6077968739724134	2.017843703726712	0.0436075416577519	1.0	0.0965006008609242	11	P04792,Q02790,Q92598,P07900,Q15185,P54652,P08238,P0DMV9,P11142	9
Signaling by alk in cancer	0.4135435057715515	2.0141468999857355	0.0439941127289396	1.0	0.0967497911148817	34	P63208,P35579,Q92734,Q63HN8,Q9HC35,P62753,Q07866,P27361,P28482,P26038,Q9NR09,O94979,P62993,P26641,P31939,P33176,Q14203,P18206,P49589	19
Negative regulation of fgfr4 signaling	0.7113846224564977	2.0128168244274467	0.0441339032883281	1.0	0.0967497911148817	6	P30153,P27361,P28482,Q06124	4
Negative regulation of fgfr1 signaling	0.7113846224564977	2.0128168244274467	0.0441339032883281	1.0	0.0967497911148817	6	P30153,P27361,P28482,Q06124	4
Negative regulation of fgfr2 signaling	0.7113846224564977	2.0128168244274467	0.0441339032883281	1.0	0.0967497911148817	6	P30153,P27361,P28482,Q06124	4
Spry regulation of fgf signaling	0.7113846224564977	2.0128168244274467	0.0441339032883281	1.0	0.0967497911148817	6	P30153,P27361,P28482,Q06124	4
Negative regulation of fgfr3 signaling	0.7113846224564977	2.0128168244274467	0.0441339032883281	1.0	0.0967497911148817	6	P30153,P27361,P28482,Q06124	4
Mtor signalling	0.5449501058504483	2.0113118024316496	0.0442925326348015	1.0	0.0969460581694643	15	Q04637,P54646,P62942,P62753,Q9Y376,P06730,P54619,Q15382	8
Activation of ampk downstream of nmdars	0.7097039691275566	2.004911511025101	0.0449725078919331	1.0	0.0981281937362088	6	P54646,Q13885,P04350,Q9BUF5	4
Phospholipid metabolism	0.359724278380288	2.0027998886136267	0.045198771838087	1.0	0.0984687529329754	51	P35790,Q9BVG9,O00459	3
Intrinsic pathway for apoptosis	0.488356557360353	2.00091727974195	0.0454013050712607	1.0	0.0987566372325252	21	P27361,P63167,P28482,Q07812,Q04917,P61981,P27348,Q13625,P42771,P63104	10
G protein beta gamma signalling	0.6019164149969345	1.9948295873670665	0.0460614692151597	1.0	0.0998829077416833	3	Q16512	1
G beta gamma signalling through cdc42	0.6019164149969345	1.9948295873670665	0.0460614692151597	1.0	0.0998829077416833	3	Q16512	1
Host interactions of hiv factors	0.3116264871954991	1.9881171252440544	0.0467987377937233	1.0	0.1011487700425144	95	P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P28070,P63208,P25786,P49721,Q99436,Q9BXS5,O14818,P35998,Q92530,P17980,P61289,P49720,P48556,Q15008,P60900,Q15370,Q06323,Q99460,Q13177,O75832,P62826,P62195,P43686,P43487,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q10567,Q13200,P25789,P52294,P28066	43
Rna polymerase ii transcription	0.2258537759430804	1.98754972369225	0.0468615114238306	1.0	0.1011487700425144	317	P00390,Q14739,P28074,P51665,Q9UQ84,P28070,Q13625,Q15382,Q8TBX8,P49721,Q99436,Q9GZS3,Q92530,P06400,Q15008,P27361,Q16763,Q12962,P54646,P23193,Q13451,O75832,P62195,Q05519,Q8IXH7,P55036,P25788,O00232,Q9H3P2,P25789,Q96PU5,P35269,P30153,P28072,P20618,Q71SY5,O94992,P51003,P11802,P17980,P25440,P30154,P42771,Q00535,Q92541,P60900,P49327,Q99460,P06493,Q07812,Q06124,Q9UNM6,P18074,O00487,O14744,Q9H814,P54619,P06744,P63104,P43246,P25787,Q16881,Q96J02,P63208,P31350,Q9NQ88,P25786,Q9UPN9,Q15291,Q9UNE7,O14818,O60244,P17931,P27348,Q13263,P49720,P55199,P48556,P42858,Q15370,Q8IYB3,Q13526,P28482,P61981,O00231,Q96ST2,O43809,O60508,P40938,P42224,O43242,P28066,P62191,P62333,Q99873,Q96P16,P09874,P32780,P12004,P14635,P35998,Q00403,P61289,Q06323,Q04917,P15927,O96017,P43686,P49841,P54132,Q13200	111
Nuclear receptor transcription pathway	0.5318073721759699	1.9792779592849168	0.0477847197310579	1.0	0.1029830442130172	2	Q9UHY1	1
Mastl facilitates mitotic progression	0.7229991074085009	1.9582198269224869	0.0502042235928412	1.0	0.1076645802996471	5	P30153,P06493,P30154,Q96GX5	4
Pyrimidine salvage	0.5950044603032939	1.9570577985588813	0.0503406733261357	1.0	0.1076645802996471	3	Q9BZX2,P04183	2
Termination of translesion dna synthesis	0.5106010175423034	1.955699335412943	0.0505005830797327	1.0	0.1078421888293226	18	P49005,P12004,Q9NRF9,P15927,P40938,P56282,P27694,P28340,Q14258,Q14694,P40937	11
Role of phospholipids in phagocytosis	0.6623838754873366	1.9542453806726596	0.0506722048362833	1.0	0.1080442300688533	4	O00459	1
Telomere c strand synthesis initiation	0.6981462513313844	1.950377846300239	0.0511311003528733	1.0	0.1088572591731128	6	Q14181,P09884,P49642	3
Regulation of localization of foxo transcription factors	0.6612258923681661	1.948523246563481	0.0513523860267211	1.0	0.1089975757874276	4	P27348,P63104	2
Josephin domain dubs	0.5921291345411491	1.941302557930502	0.052221589461237	1.0	0.1105081297347142	3	P54727	1
Sealing of the nuclear envelope ne by escrt iii	0.5922777457315016	1.9297887974598504	0.0536330121070594	1.0	0.1129836576369434	11	Q9Y3E7,Q8WUX9,Q9H444,P04350,P53990,Q9BUF5,Q13885,Q9UN37	8
Extension of telomeres	0.4126204560612344	1.9282951218422033	0.0538184282421714	1.0	0.1132042800956019	32	Q14181,P09884,P54132,P51530,Q9NPE3,P49005,P12004,P18858,Q8WVB6,P49643,P15927,P40938,P27694,P24941,P28340,P49642,P39748	17
Condensation of prometaphase chromosomes	0.6220920203703312	1.9225157399351351	0.0545408949919026	1.0	0.1142102621994617	9	Q15021,Q9NTJ3,P06493,Q15003,Q9BPX3,O95347	6
Signaling by fgfr1	0.6656953844436402	1.9039551129947752	0.056916030381775	1.0	0.1181260216355479	7	P30153,P27361,P28482,Q06124	4
Signaling by fgfr3	0.6656953844436402	1.9039551129947752	0.056916030381775	1.0	0.1181260216355479	7	P30153,P27361,P28482,Q06124	4
Signaling by fgfr4	0.6656953844436402	1.9039551129947752	0.056916030381775	1.0	0.1181260216355479	7	P30153,P27361,P28482,Q06124	4
Glycerophospholipid biosynthesis	0.4097532441400753	1.9021949528955495	0.057145672420837	1.0	0.1184274422547035	32	P35790	1
Signaling by braf and raf1 fusions	0.4549841089232011	1.9010522813467383	0.0572951650162685	1.0	0.1185521725060818	23	P27361,Q9Y490,P46940,P28482,P36507,O00203,O43252,P18206,Q02750,P30086	10
Phosphorylation of emi1	0.6511059459013995	1.8983788517750448	0.0576461934466094	1.0	0.1186266765935122	4	P06493,P14635	2
Methylation	0.6644005769559294	1.8975564309573296	0.0577545384210873	1.0	0.1186266765935122	7	P23526,P78417,Q9HBK9,Q99707,Q9NZL9	5
Cooperation of pdcl phlp1 and tric cct in g protein beta folding	0.5703039393783433	1.89552601443048	0.0580227486275046	1.0	0.1188407537582321	12	P40227,P50991,P49368,P50990,P48643,Q99832,P17987	7
Insulin receptor signalling cascade	0.684599905529438	1.8860912251968815	0.0592826625710691	1.0	0.1212442792816473	6	P27361,P28482,Q06124,O00459	4
Signaling by tgfb family members	0.4819884854445636	1.883789956513546	0.0595933926265541	1.0	0.1215254794404876	20	Q9Y3F4,P61081,Q9UNE7,P28482,P62942,Q9Y5K5,Q96PU5	7
Glutathione synthesis and recycling	0.6592646551989729	1.8721383533890137	0.0611874650818029	1.0	0.1244145123329993	7	Q8WUX2,O75223,P48506	3
Signaling by tgf beta receptor complex	0.4894120560681657	1.8710767192896864	0.0613344479420538	1.0	0.1245328950256173	19	Q9Y3F4,P61081,Q9UNE7,P28482,P62942,Q9Y5K5,Q96PU5	7
Prolonged erk activation events	0.6358267365402	1.8697935854937375	0.0615124874769796	1.0	0.1247139016332406	8	P27361,P28482,P36507,P46108,Q02750	5
Flt3 signaling	0.6426433485270993	1.8562608956149056	0.0634163799920655	1.0	0.128304920983526	4	P62993,Q06124	2
Dna replication initiation	0.6331387338815525	1.8559086317737847	0.0634665824394633	1.0	0.128304920983526	8	Q14181,P09884,Q9NRF9,P49643,P49642	5
Metabolism of porphyrins	0.5788294922525502	1.852903168623942	0.0638962388763721	1.0	0.1289876591993528	11	P22830	1
Tnfr1 induced proapoptotic signaling	0.6409212560589721	1.8476697909239856	0.0646501266870807	1.0	0.1299486070801923	4	Q13546	1
Rho gtpases activate wasps and waves	0.4860101816232047	1.8469609404692215	0.0647528014394256	1.0	0.1299687845772734	19	P62993,Q9Y6W5,P27361,O15143,Q9UQB8,P28482,Q9Y2A7,Q96F07,O15145,P63000	10
E2f enabled inhibition of pre replication complex formation	0.6749705852441955	1.8401575723258827	0.0657451069073329	1.0	0.1316313149127754	6	P06493,Q9UBD5,Q13416,Q9UJA3	4
Myd88 independent tlr4 cascade	0.4570351096250367	1.8399965297813432	0.0657687467953354	1.0	0.1316313149127754	22	P30153,P27361,P09429,Q14738,Q13546,P28482,P63208,Q06124,P61088,P51452,Q02750	11
Processive synthesis on the c strand of the telomere	0.5438965518388403	1.833942617663596	0.0666625124763224	1.0	0.132663127665646	13	P54132,P51530,P49005,P12004,P18858,P15927,P28340,P39748	8
Mhc class ii antigen presentation	0.3444448513879389	1.825743411175632	0.0678889208499813	1.0	0.1343415457722479	51	Q13561,P47755,P61163,P52907,Q9H0H5,Q9NZ32,Q13409,Q14204,P63167,Q9BXS5,Q9Y6G9,Q07866,Q13885,O43237,O94979,P50570,P52732,Q9UJW0,Q99538,P33176,P04350,Q14203,Q9BUF5,Q99661,Q10567	25
Phase ii conjugation of compounds	0.410613336013367	1.81242460320278	0.0699206141250989	1.0	0.1377789629459464	29	Q8WUX2,P23526,P14550,P48506,Q96KP4,O75223,P28161,P21266,P78417,O60701,Q9HBK9,Q99707,O43252,Q9NZL9,P31153	15
Negative regulation of the pi3k akt network	0.5400113880508848	1.8100658297170933	0.0702855791812595	1.0	0.1383038816147365	13	P30153,P27361,Q14738,P28482,Q06124,P30154,Q8TBX8,O00459	8
Maturation of sars cov 2 nucleoprotein	0.6894754091342066	1.8044779704186171	0.0711564096134786	1.0	0.1398213483021156	5	Q96SB4,Q99873,P49840	3
Polymerase switching on the c strand of the telomere	0.496279429371708	1.7983798359755616	0.0721168359187367	1.0	0.1411156496429395	17	Q14181,P09884,P49005,P12004,P49643,P49642	6
Signaling by vegf	0.4039040486950161	1.7829601255216037	0.0745927944523536	1.0	0.1447492263024235	30	O43865,P04792,P06756,Q9UQB8,P46108,Q96JJ3,O00459	7
Ovarian tumor domain proteases	0.5960556457549875	1.7819951004741377	0.0747500307207453	1.0	0.1448539959961405	9	Q13546,Q6GQQ9,P06493,Q14258	4
Hdr through homologous recombination hrr	0.4487978023461679	1.7768663491961991	0.0755902321521557	1.0	0.1461048660856179	22	P54132,P51530,P49005,P12004,Q9UQ84,Q9NRF9,P15927,P40938,P56282,P27694,P28340,P40937	12
Autophagy	0.3380358205559516	1.7767839051051797	0.0756038009822941	1.0	0.1461048660856179	52	P60520,Q15382,Q13409,Q14204,P63167,Q9Y6G9,Q99497,Q13885,Q9Y3E7,Q8WUX9,Q9H444,O43237,P54646,O60664,P07900,Q99816,P61088,P08238,P11142,Q9H9H4,O75143,P04350,Q9BUF5,P54619	24
Glucuronidation	0.5608636837203815	1.7684333244296078	0.0769884896132713	1.0	0.1483720479772247	3	O60701	1
Activation of bh3 only proteins	0.5786262616576383	1.766083851183093	0.0773817823096645	1.0	0.1489254328950059	10	P63167,Q04917,P61981,P27348,Q13625,P63104	6
Phenylalanine and tyrosine metabolism	0.6235447883122442	1.7606096666822555	0.0783044913747104	1.0	0.1504947964366009	4	P16930,Q7L266	2
Downregulation of tgf beta receptor signaling	0.636724287513872	1.7599003770818034	0.0784246993928716	1.0	0.1505196350864554	7	Q96PU5,Q9Y5K5,Q9UNE7	3
Cytosolic sensors of pathogen associated dna	0.4459959552714476	1.755328124876088	0.0792031984079015	1.0	0.1515990277848375	22	Q13546,P19474	2
Glycogen synthesis	0.6786122535967203	1.7541976417850318	0.079396647174299	1.0	0.151762256111092	5	P46976	1
Srp dependent cotranslational protein targeting to membrane	0.2972301255742661	1.7521109753737916	0.0797547274022512	1.0	0.1522392959800795	92	Q9UHB9,P18621,P62910,P42766,P25398,P62249,P05388,P08865,P62266,P62861,P62081,P62753,P62854,P35268,P62899,P39019,P62750,P62701,P15880,P62851,P60866,P30050,P46781,P46783,P60059,P62273,P61011,P46777,P63173,P46782,P23396,P62277,P62244,P61247,P62841,P62857,P27635,P09132,P62913,P62847,P62888,P08708,P61513,P62269,P46778,O76094,P62906,P62829,P37108,P32969	50
Post translational protein modification	0.2248644648153297	1.7417701218481143	0.081548676806846	1.0	0.1552412395658141	415	P22314,P28074,P51665,Q06210,P28070,Q13564,P49721,Q99436,Q9GZS3,Q92530,Q99497,P61962,Q8TBC4,P13639,P15880,Q15008,Q9H9E3,Q13546,Q16763,Q12962,O75832,P61088,P62195,Q9Y678,Q96FW1,P53621,Q6GQQ9,P61086,P55036,P25788,O00232,O60763,Q9BUF5,O75150,P25789,P28072,O60826,P20618,Q86VP6,Q9UBE0,P61163,P52907,Q9UNS2,Q9NP61,Q92734,Q9NZ32,Q14746,Q9Y6G9,O60493,P07942,P17980,Q13630,A0AVT1,P42771,Q92541,Q13885,Q13098,Q8TEY7,Q9UBT2,P60900,Q9Y5A7,Q92930,Q99460,P06493,P63241,Q9BT78,Q9UNM6,P61081,Q9UP83,O00487,O14964,P49366,Q13190,P63208,P25786,Q96K76,Q14527,P49720,P54727,Q9H2P9,O43292,O94979,P18085,Q7L5N1,Q9NR45,Q14203,Q14964,P14735,O43242,P54578,P62191,Q04323,P47755,P61923,P62333,Q9UBW8,Q9Y5K5,O15498,P45974,P12004,Q5VTR2,Q16222,Q9BU89,Q9UBI1,Q06323,P35606,O43237,O14579,P68036,P48444,P43686,Q92905,Q9BTE7,Q9BQC3,Q99627,Q9UJW0,Q9H9Q2,Q9NYU1,Q13200,Q14258,O15027	121
Oncogenic mapk signaling	0.415407674431211	1.7382729157742542	0.0821627363515449	1.0	0.1561982643647933	26	P27361,Q9Y490,P46940,P28482,P36507,O00203,O43252,P18206,Q99956,Q02750,P30086	11
Mtorc1 mediated signalling	0.5420231688723409	1.7273775415361172	0.084099881340155	1.0	0.159448829081402	12	P06730,P62942,Q15382	3
Hsf1 dependent transactivation	0.5010410946526025	1.7262214273579164	0.0843075845826943	1.0	0.1595319149662467	15	P04792,Q02790,Q92598,P07900,Q15185,Q8N122,P54652,P08238,P25685,P0DMV9,P11142	11
Ngf stimulated transcription	0.5520274417222126	1.719087675097326	0.0855984086518235	1.0	0.161634680132582	3	Q00535	1
Signaling by type 1 insulin like growth factor 1 receptor igf1r	0.6708833170932507	1.7182949697651777	0.0857428264296467	1.0	0.1616897654311751	5	O00459	1
Oncogene induced senescence	0.6281570971784067	1.7169621110715052	0.0859860950335176	1.0	0.161930860848356	7	P27361,P28482,P11802,P06400	4
Pyroptosis	0.6049939475854684	1.7095287798080463	0.087353045382442	1.0	0.1642846148412415	8	Q9Y3E7,P09429,Q07812	3
Rho gtpase effectors	0.2853601600128982	1.7046224887392554	0.0882648543555433	1.0	0.1653345669703969	111	P30153,P35240,Q8NBT2,Q15691,Q16513,P35579,Q13409,Q9Y6W5,O60566,P50748,P63167,Q14738,P35080,Q14204,O14974,P84095,Q9NSV4,Q9Y6G9,P62258,Q9Y2A7,Q14247,Q07866,P30154,P27348,Q16512,Q13885,O15145,P27361,P60660,P07737,Q8NFH4,O43237,Q13526,Q9UQB8,P28482,Q99570,P23528,Q04917,P61981,Q13177,Q86VI3,P43034,P62993,Q7Z460,Q12834,O15143,Q9P258,Q14008,P46940,Q15058,P33176,O60610,P04350,Q96F07,Q9Y266,Q9BUF5,Q99661,Q15334,P63104	59
Infection with mycobacterium tuberculosis	0.51012394856641	1.7022238918267605	0.0887134056510476	1.0	0.165511845915452	14	P27361,P06733,Q9UI12,P28482,O14964,P49840,P52294,P00558	8
Response of mtb to phagocytosis	0.51012394856641	1.7022238918267605	0.0887134056510476	1.0	0.165511845915452	14	P27361,P06733,Q9UI12,P28482,O14964,P49840,P52294,P00558	8
Gamma carboxylation hypusine formation and arylsulfatase activation	0.5670017309128167	1.7008064052473146	0.0889793461175152	1.0	0.1657875466173624	10	Q9BQC3,Q9H2P9,P63241,P49366,Q9BU89	5
Signalling to erks	0.5650548443337364	1.6898422836313014	0.0910581319496	1.0	0.1694357548080753	10	P27361,P28482,P36507,P46108,Q02750	5
Receptor type tyrosine protein phosphatases	0.4848394768133047	1.687664557433506	0.0914756390447557	1.0	0.1699871809003871	2	Q13136	1
Nucleotide salvage	0.6211298922760858	1.6816344820048676	0.0926397398517817	1.0	0.1719226918148806	7	P00491,P07741,P00492,P04183,Q9BZX2	5
Signal regulatory protein family interactions	0.5441236789469222	1.6747800637513526	0.0939773918309661	1.0	0.1741747433802449	3	Q06124	1
Deadenylation of mrna	0.5049902508422545	1.6694129264252329	0.0950355736162886	1.0	0.1759035749124709	14	P23588,Q04637,P60842,Q14240,P11940,A5YKK6,Q9H074,P06730,Q9HBH5	9
Translesion synthesis by polh	0.5458210702656769	1.6620849021141195	0.0964957523382115	1.0	0.1779021557562559	11	P12004,Q8TAT6,P55072,P15927,P40938,P27694	6
Interleukin 17 signaling	0.4880404760566741	1.6405876677416635	0.1008830366535351	1.0	0.1852603408703008	15	P30153,P27361,Q14738,P28482,P63208,P61088,P51452,Q02750	8
Trafficking of myristoylated proteins to the cilium	0.5377685186492343	1.6390432344920294	0.1012042558521053	1.0	0.1856072823013121	3	A6NIH7	1
Tp53 regulates transcription of cell death genes	0.6498127390689004	1.619906256593876	0.1052524156602539	1.0	0.190540824737208	5	Q13625	1
Interleukin 2 family signaling	0.6444691886764359	1.594843715316038	0.1107471886355346	1.0	0.1991356223675355	5	P62993,O00459	2
Activation of bad and translocation to mitochondria	0.6240705839712923	1.5943766905398689	0.1108516899993194	1.0	0.1991356223675355	6	P61981,P27348,P63104,Q04917	4
Bbsome mediated cargo targeting to cilium	0.603418564188749	1.5921936689655738	0.1113411953340401	1.0	0.199759203393425	7	P50991,P49368,P50990,P48643,P17987	5
Homology directed repair	0.3548022945416605	1.5906814446134927	0.1116812848861721	1.0	0.2001134644895268	39	P18887,P54132,P09874,P49005,P51530,P12004,Q9UQ84,Q9NRF9,P15927,P40938,P56282,P27694,P61088,P24941,P28340,Q9NY27,P40937,P39748	18
Activation of nima kinases nek9 nek6 nek7	0.5896180469244147	1.5888210992818692	0.1121007883260858	1.0	0.2001576420751861	4	P06493,P14635	2
Trna aminoacylation	0.3646609542693795	1.5886743530910796	0.1121339320535255	1.0	0.2001576420751861	35	P49591,P26639,P26640,Q9Y285,P54577,Q15046,P47897,P23381,P49588,Q5JPH6,P14868,Q9NSD9,Q9P2J5,O43776,Q15181,P07814,P41252,O43324,P54136,P49589,P41250	21
Rhobtb3 atpase cycle	0.5874423640763808	1.5777312317214416	0.1146273680982417	1.0	0.2035724018251052	4	O60664	1
Cholesterol biosynthesis	0.4627861853298302	1.5685464330668917	0.116753662475125	1.0	0.2070864582207338	17	Q9UBM7,Q14739	2
Rora activates gene expression	0.524531668153442	1.5643140536510312	0.1177438333234053	1.0	0.2083160128029479	3	Q15648,P50416	2
Translation of replicase and assembly of the replication transcription complex	0.6352276108301096	1.551401660136967	0.1208054576373967	1.0	0.2131950403336699	5	Q9Y3E7,Q8WUX9,Q9UQN3,Q9H444	4
Egfr downregulation	0.5526890013151583	1.5444426234530888	0.1224811409721438	1.0	0.2150701386532137	9	P62993,O14964,Q9UBC2,P42566,O75886,Q99961	6
Generation of second messenger molecules	0.5797144556811474	1.5382774266756936	0.1239807966255905	1.0	0.2171598722418271	4	Q8N8S7,Q13177,Q16512	3
Met receptor recycling	0.6314017039160884	1.533383203695044	0.1251814647245468	1.0	0.2185425892158544	5	P46108,P46109	2
Interleukin 6 family signaling	0.5784654958195545	1.531892125753688	0.125549056955081	1.0	0.2185425892158544	4	Q06124	1
Interleukin 6 signaling	0.5784654958195545	1.531892125753688	0.125549056955081	1.0	0.2185425892158544	4	Q06124	1
Energy dependent regulation of mtor by lkb1 ampk	0.5709508524342783	1.5303111107440213	0.1259397393870813	1.0	0.218734967454025	8	Q15382	1
Biosynthesis of specialized proresolving mediators spms	0.5185075837241764	1.5301832129570287	0.1259713853904862	1.0	0.218734967454025	3	Q14914	1
Signal transduction by l1	0.5085401351981841	1.5256038143121704	0.1271085616316063	1.0	0.2201645826779551	12	Q02750,P36507,P28482,P06756	4
Inlb mediated entry of listeria monocytogenes into host cell	0.6094384336596527	1.5229166549512572	0.1277795584054981	1.0	0.2210539093007569	6	P62993,O14964,P42566,O75886	4
Regulated necrosis	0.4324529546192492	1.5202816331127542	0.1284402081414013	1.0	0.2219231675152537	20	Q9Y3E7,P49327,P09429,Q9UNE7,Q9H444,Q13546,P07900,Q07812,Q16543	9
Tp53 regulates transcription of genes involved in g2 cell cycle arrest	0.5685806685680113	1.5177593820238244	0.1290750680852701	1.0	0.2227457817018868	8	P14635,P12004,P06493,Q99873,Q07812	5
Trna modification in the nucleus and cytosol	0.5210045949371613	1.516937453363588	0.1292824763567828	1.0	0.2228296244822681	11	P57081,Q9H974,Q96PZ0	3
Met activates rap1 and rac1	0.6269294571256452	1.51229704505412	0.130458312449377	1.0	0.2245803832717496	5	P62993,P46108,P46109	3
Rho gtpases activate pkns	0.4468540883165163	1.5102543870255063	0.1309785257492635	1.0	0.2251995975811479	18	P60660,O14974,Q04917,Q16513,P61981,P27348,P35579,Q16512,P63104	9
Signaling by ntrk3 trkc	0.5719809637121027	1.4987024956581725	0.1339508290087134	1.0	0.2300281678081089	4	P62993,Q07812,P19174	3
Cytochrome c mediated apoptotic response	0.571655887413133	1.497037066583854	0.1343836135123517	1.0	0.2302078263221361	4	P28482	1
Formation of apoptosome	0.571655887413133	1.497037066583854	0.1343836135123517	1.0	0.2302078263221361	4	P28482	1
Ret signaling	0.5811958359746682	1.4792592271540057	0.139071045556288	1.0	0.2376573409445457	7	O00459	1
Formation of tc ner pre incision complex	0.3684784477889867	1.4641574110350752	0.1431509437994811	1.0	0.2437388035809126	30	Q99627,Q7L5N1,P32780,P18074,Q9H9Q2,Q9UBW8,P23193,Q9UNS2,Q13098,Q92905	10
Intraflagellar transport	0.4981189833593094	1.4623366540277236	0.1436489788701465	1.0	0.2442086294851768	12	P63167,Q9Y366,P04350,Q9BUF5,Q13885	5
Glycogen metabolism	0.5223704800556348	1.447537038712684	0.1477465705846432	1.0	0.2493447832914644	10	P06737,P11216,P36871,P46976	4
Apoptotic factor mediated response	0.5552677523454892	1.4471133176522777	0.1478651886660715	1.0	0.2493447832914644	8	P27361,P28482,Q07812	3
Repression of wnt target genes	0.5596552233609767	1.4354579054111285	0.1511566553973207	1.0	0.2545891806992088	4	Q04726,Q13363	2
Constitutive signaling by aberrant pi3k in cancer	0.5903716499191376	1.4293835049456691	0.1528940367704989	1.0	0.2572066349988129	6	O00459	1
Sulfur amino acid metabolism	0.5497416812592424	1.4177250341942034	0.1562710582451085	1.0	0.2622587257390997	8	P25325,Q13126,P17174,P23526	4
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10	0.5874109723767905	1.4148247056189798	0.1571198985389315	1.0	0.2630539590096908	6	Q13546	1
Synthesis of leukotrienes lt and eoxins ex	0.4979570292263195	1.413265844218568	0.1575775727909945	1.0	0.2635057623668239	3	Q14914	1
Base excision repair ap site formation	0.5867926434079445	1.4117831204805686	0.1580138300316105	1.0	0.2639207184932732	6	P13051	1
Constitutive signaling by egfrviii	0.6050194427277236	1.4086695661496789	0.1589328980207782	1.0	0.2645110983667282	5	Q16543,P07900	2
Constitutive signaling by ligand responsive egfr cancer variants	0.6050194427277236	1.4086695661496789	0.1589328980207782	1.0	0.2645110983667282	5	Q16543,P07900	2
Signaling by egfr in cancer	0.6050194427277236	1.4086695661496789	0.1589328980207782	1.0	0.2645110983667282	5	Q16543,P07900	2
Recognition of dna damage by pcna containing replication complex	0.4242315168435374	1.4023214982316357	0.1608192634822094	1.0	0.2673334439165163	19	P49005,P12004,Q9NRF9,P15927,P40938,P56282,P27694,P28340,P40937	9
Purine salvage	0.6031089673633319	1.3996117551696097	0.1616296118959845	1.0	0.2680760849776036	5	P00491,P07741,P00492	3
Signaling by met	0.4070858811351978	1.3901473682997207	0.164484131844725	1.0	0.2714955729154696	21	P62993,Q96S59,P46109,O14964,P07942,Q96N67,P46108,P42566,Q06124,O75886,Q99961,Q96P70	12
Disorders of transmembrane transporters	0.2743449930507193	1.386195972682026	0.1656870709233597	1.0	0.2731597655763499	80	P28072,O43242,P25787,P62191,P20618,P28074,P62333,P51665,P28070,P25786,P49721,Q99436,O14818,P35998,Q92530,P17980,P61289,P49720,P48556,Q15008,P60900,Q06323,Q99460,P11166,O75832,P62195,P43686,Q9UNM6,O00231,O00487,P55036,P25788,O00232,Q13200,P25789,P28066	36
Cyclin d associated events in g1	0.4980341278620659	1.3816512796652678	0.1670788005589574	1.0	0.2751309356622268	11	P30153,P11802,P63208,P30154,P63151,P06400	6
Nef mediated downregulation of mhc class i complex cell surface expression	0.5487609312664051	1.3794131147616089	0.1677674179679544	1.0	0.2759410168921924	4	Q10567	1
Sensory processing of sound	0.4206601275850051	1.3763489584693285	0.1687136222248608	1.0	0.2771723793694142	19	P47755,Q00013,P26038,P52907,Q12792,Q6IBS0,Q14651,P15311	8
Cd28 dependent vav1 pathway	0.593229491883007	1.3527283703363169	0.1761424235122688	1.0	0.2880277624565421	5	P62993,Q13177,Q16512	3
Semaphorin interactions	0.4019223881716143	1.3507529349875351	0.1767745891650505	1.0	0.2887249692649195	21	P60660,P49841,Q14195,Q9Y490,P07900,P23528,Q16555,Q13177,Q00535,Q16512,P08238	11
Activation of atr in response to replication stress	0.4170476983037833	1.3500662315408898	0.1769947389547648	1.0	0.2887483938994593	19	P33991,P25205,P40937,P49736,P15927,Q13416,Q7L590,P27694,P40938,P24941,Q9UJA3,P33992,Q9UBD5	13
Chaperone mediated autophagy	0.554547744635948	1.3430603813000597	0.179252422911867	1.0	0.2920793406595015	7	O60664,Q99497,P08238	3
Dcc mediated attractive signaling	0.4853334763957732	1.3411577373327268	0.1798692447111969	1.0	0.2920793406595015	3	P63000	1
Pi5p regulates tp53 acetylation	0.4837759788524534	1.332250126644056	0.1827780097111371	1.0	0.2964595926297403	3	Q8TBX8	1
Transcriptional activity of smad2 smad3 smad4 heterotrimer	0.5325476924025397	1.3261085994474169	0.1848037281111358	1.0	0.2990537837830723	8	P27361,P09874,P28482,Q96PU5,Q9UPN9	5
Diseases of dna repair	0.5125358355557484	1.3217009092704397	0.1862677657725522	1.0	0.3010756628789064	9	P43246,P54132,P20585,P52701,Q9UQ84	5
Integration of energy metabolism	0.3694531034302556	1.3157250800544775	0.1882663331945497	1.0	0.3036065120367279	25	O43865,P30153,P49327,Q14738,Q13085,P46940,P54646,P29401,Q9UBI6,P11166,P30154,P17612,O60488,P53396,P37837,O00763	16
Signaling by egfr	0.4497794474411287	1.3129475704374556	0.1892006157153138	1.0	0.3047628746826468	14	P62993,P41240,O14964,Q9UBC2,Q13685,P42566,Q06124,O75886,Q99961,Q14155	10
Neutrophil degranulation	0.2380322885425211	1.311982482399148	0.189526045193467	1.0	0.3049369740899476	178	P06737,P51665,P42785,Q13442,P50395,P63167,P46976,Q99436,Q9BXS5,Q01518,P84095,P55072,P53990,Q9Y376,P13639,Q15008,P18669,O00232,P50990,P09960,P11216,P14174,P35573,P06756,P20618,Q86VP6,Q9NZ32,P07741,Q9Y6G9,P17980,P09972,Q99460,Q9UJU6,Q9UNM6,Q9Y5Z4,P04075,P78371,O00487,O60610,P13010,P18206,P06744,P48960,P31949,P00491,P07437,P25787,P09429,Q9UQ80,P36871,Q14204,P17931,P53396,Q14019,P28482,P30041,P08238,Q9NQR4,O00231,O75787,P37108,O43242,P28066,Q96G03,Q7Z6Z7,Q9Y5K8,P13798,P02792,P35998,Q9UBI1,P04080,P07900,P14618,P0DMV9,P11142,P12268,P17858,P46940,Q99439,Q13200	80
Rrna modification in the mitochondrion	0.4256837098691899	1.3111551795515726	0.1898053414575615	1.0	0.3050365338659322	2	Q9HC36	1
Metabolism of nitric oxide nos3 activation and regulation	0.5840198872254528	1.3089714169520406	0.1905440330464303	1.0	0.3052944569400029	5	O75608,P07900,P50570	3
Rho gtpases activate paks	0.4588577757910455	1.3028847563546937	0.1926141088814987	1.0	0.3077876933493653	13	P35240,P60660,O14974,Q14247,P35579,Q13177,Q16512,P63000	8
Carboxyterminal post translational modifications of tubulin	0.5821524650939272	1.300094345086186	0.1935686355849712	1.0	0.3082597000291881	5	P04350,Q13885,Q9BUF5	3
Intra golgi traffic	0.4161123006041658	1.291814135165633	0.1964215190160885	1.0	0.3124482893192428	18	Q14746,Q13190,Q14964,Q9H9E3	4
Signaling by ntrk2 trkb	0.5798869384111807	1.289323285894437	0.197285718844711	1.0	0.313467569126987	5	P62993,Q06124,P63000,Q00535	4
Cdc42 gtpase cycle	0.3333373163814549	1.2843777207889155	0.1990098244797817	1.0	0.3154924110114506	35	P63167,Q96HP0,Q14739,Q68EM7,Q86VI3,P46940,Q9NSV4,Q9UQB8,P52565,Q96N67,Q13177,P11274,Q16512,Q9H0H5,Q9NP61,O00459,O15498	17
Toll like receptor cascades	0.3526053728851099	1.2742667345747505	0.2025689015269975	1.0	0.3204105623927594	28	P30153,P27361,P09429,Q14738,Q13546,P28482,P63208,Q06124,P61088,P51452,Q02750	11
Interleukin 3 interleukin 5 and gm csf signaling	0.4655722626939855	1.2639308525613229	0.2062548468419975	1.0	0.3258733672514894	12	P46109,P46108,Q06124,O00459,P63104	5
Mrna decay by 5 to 3 exoribonuclease	0.4864586260840202	1.2418461581278502	0.214293328610446	1.0	0.3366901875045895	10	Q8IZD4,Q86TB9	2
Extra nuclear estrogen signaling	0.4596881611934762	1.2280145802315392	0.2194414947185838	1.0	0.3432290045598363	12	P04792,O00459,P28482,P07900	4
Glycogen breakdown glycogenolysis	0.5312631501773927	1.223705346007669	0.2210634022187303	1.0	0.3453807943350541	7	P06737,P35573,P11216,P46976	4
Pi3k akt signaling in cancer	0.4830716260880901	1.222425282501573	0.2215468432134151	1.0	0.3454292483984336	10	P62993,P49841,P84095,Q06124,P49840,O00459,P63000	7
Organelle biogenesis and maintenance	0.2614587420761928	1.222319492438767	0.2215868307616466	1.0	0.3454292483984336	96	P30153,P07437,Q15019,Q7Z4H7,P61163,Q15691,Q9H6D7,P48643,P17987,A6NIH7,P36405,Q14204,Q9Y366,Q8TAG9,Q13885,P50991,P54646,P06493,P07900,P49368,P18085,P43034,P23258,P78371,P50990,P04350,Q14203,Q9BUF5,P54619	29
Sars cov infections	0.2744621470854322	1.2150681488596815	0.2243401004118177	1.0	0.348598136752291	62	Q96SB4,Q99720,P07437,Q9Y3E7,Q02790,Q9H444,Q13546,P62942,P07900,P08238	10
Wnt ligand biogenesis and trafficking	0.5637062063742457	1.2123724996465106	0.2253698229119807	1.0	0.3495113471065285	5	Q9UBQ0,Q96QK1	2
Regulation of glycolysis by fructose 2 6 bisphosphate metabolism	0.5619983204020338	1.2042509031108632	0.2284926168071068	1.0	0.3526679223106391	5	P30153,Q14738	2
Tp53 regulates transcription of cell cycle genes	0.4328391554494176	1.202956370516339	0.228993204502772	1.0	0.3530521603487793	14	P14635,P12004,P06493,Q99873,Q07812,A5YKK6,P24941,O14965	8
Synthesis of ip3 and ip4 in the cytosol	0.4594112399643264	1.192762218720382	0.2329625105807953	1.0	0.3579916783623831	3	P19174,Q01968	2
E3 ubiquitin ligases ubiquitinate target proteins	0.4018219615474035	1.1901498726483088	0.2339874912038082	1.0	0.3591733590360426	18	P12004,Q9GZS3,Q5VTR2,Q14527,P68036,P61088,Q92541	7
Nuclear events stimulated by alk signaling in cancer	0.4633798822359117	1.17684525555456	0.2392572757845508	1.0	0.3652643720628126	11	P27361,P28482,Q9HC35,P62753,P63208	5
Translesion synthesis by polk	0.5034214971269859	1.1706831460523552	0.2417261622270823	1.0	0.3684829860573923	8	P12004,P15927,P40938,P27694	4
Tnfr1 induced nfkappab signaling pathway	0.5207650831466639	1.1698996690922876	0.2420413470866393	1.0	0.3684829860573923	7	Q13546	1
Assembly and cell surface presentation of nmda receptors	0.473858021900079	1.1696211397831109	0.242153466247267	1.0	0.3684829860573923	10	P04350,Q13885,Q12959,Q9BUF5	4
Cytosolic iron sulfur cluster assembly	0.5358721788731187	1.160685954915475	0.2457696356194696	1.0	0.3731761891494761	6	P18074,Q9Y5Y2,Q6FI81	3
Retrograde transport at the trans golgi network	0.3763527042622039	1.155739631618976	0.2477876722837848	1.0	0.3754277583306157	21	Q14746,Q9UP83,Q9H9E3,O60664,Q8N1B4,P20645,P82094	7
Uptake and actions of bacterial toxins	0.5003702946105724	1.1544155964785756	0.2483298239567772	1.0	0.3758433042193727	8	Q8WUM4,P07900,P36507,P08238,P13639,Q02750	6
Rho gtpases activate cit	0.4709102133700796	1.1527402044308572	0.2490170341304154	1.0	0.3764772617294966	10	P60660,O14974,Q15058,P35579,O43663,Q15334	6
Metabolic disorders of biological oxidation enzymes	0.5493742532589347	1.1442508585430644	0.2525196166698116	1.0	0.3809516367610168	5	P48506	1
Sema3a pak dependent axon repulsion	0.4977764923959432	1.1405926636195278	0.2540394716352976	1.0	0.3828328450100135	8	P07900,P08238,P23528	3
Chrebp activates metabolic gene expression	0.5479954982709284	1.1377029525920994	0.2552445401128596	1.0	0.384236147830839	5	P49327,P53396,O00763	3
Metabolism of nucleotides	0.3011006189610239	1.1365089733038096	0.2557436122389576	1.0	0.384541200215123	43	P00491,P33316,P00390,P30566,Q16881,P49915,P17812,P31350,P30520,P07741,P00492,P22234,P27144,P23921,P15531,P22102,Q9BZX2,Q9Y3Z3,O43598,O15067,P31939,Q9BY32,Q9UKK9,P04183,P04818,P11172,P30085	27
Clathrin mediated endocytosis	0.2723576735421651	1.1358702581844318	0.25601086737377	1.0	0.384541200215123	58	Q9UNF0,Q9UBC2,Q2M2I8,Q9UBW8,Q9UNS2,Q9NP61,Q99961,Q9NVZ3,Q14247,P42566,P61201,P20645,O15145,Q13098,O14976,O14656,Q14C86,Q9BT78,O75886,P11142,Q92905,P62993,Q01968,Q99627,Q7L5N1,P50570,Q13492,O14964,Q9H9Q2,Q8N6T3,Q9UKS6	31
G2 m dna damage checkpoint	0.3319688621904258	1.1339673464930995	0.2568082453444322	1.0	0.384541200215123	30	P54132,P51530,P14635,P06493,Q9UQ84,P62258,Q04917,P61981,P27348,P15927,P40938,P27694,P61088,O96017,P63104	15
Molybdenum cofactor biosynthesis	0.500672608251907	1.1313447889700814	0.2579099997682692	1.0	0.384541200215123	4	Q9NQX3	1
Recycling of eif2 gdp	0.5131060590013412	1.1306842014207237	0.2581880332164261	1.0	0.384541200215123	7	P05198,Q9NR50,Q14232	3
Selective autophagy	0.3278014772026855	1.1193184494123192	0.2630043077453439	1.0	0.3904709457848862	31	Q13409,Q14204,P63167,O43237,P54646,Q9Y6G9,O60664,Q99497,P07900,P04350,P61088,Q9BUF5,Q13885,P54619,P11142	15
Formation of rna pol ii elongation complex	0.3152553872294078	1.1094978230017274	0.2672154830648865	1.0	0.3958852404857822	35	Q8IXH7,P32780,Q96ST2,Q9GZS3,P18074,P23193,Q9H3P2,Q92541,P55199	9
Rho gtpases activate nadph oxidases	0.5226315181331798	1.0954725423083218	0.2733096683789733	1.0	0.4040605529354052	6	Q13526,P27361,P28482,Q99570	4
Regulation of signaling by cbl	0.5054755582119175	1.091669680647711	0.2749783163984389	1.0	0.4052464053645062	7	P46108	1
Toll like receptor tlr1 tlr2 cascade	0.3802723045321439	1.082834745054041	0.278881780415122	1.0	0.4101374611346082	19	P30153,P27361,P09429,Q14738,P28482,P63208,P61088,P51452,Q02750	9
Regulation of tp53 activity through phosphorylation	0.3304768632456518	1.079689488194892	0.2802804764426583	1.0	0.4113321218086292	28	Q9Y5B9,P54132,P51530,P54646,Q12962,Q13526,Q9UQ84,P15927,P40938,P27694,Q00535,P24941,O96017,P54619,P40937,O14965	16
Oas antiviral response	0.4394885518882044	1.0788505831845283	0.2806543412407372	1.0	0.4114504083184475	3	P21333,P61221	2
Parasite infection	0.3339182801721533	1.0766685467510344	0.2816283689021186	1.0	0.4124473920351487	27	P62993,Q9Y6W5,P27361,O15143,Q9UQB8,P28482,Q9Y2A7,Q96F07,P46108,P35579,Q96JJ3	11
Rna polymerase iii transcription termination	0.4683055845214059	1.075687129635599	0.282067205376213	1.0	0.4126593213168162	9	Q9H1D9,P05455	2
Protein methylation	0.5016301438935645	1.0720356417422787	0.2837040237165593	1.0	0.4146216096607633	7	O60678,P55072,P13639,P11142,P15880	5
Cargo trafficking to the periciliary membrane	0.357445479094256	1.0656864855792043	0.2865653888098616	1.0	0.4170656021786679	22	P36405,P50991,P78371,P49368,P50990,P48643,Q8TAG9,P18085,P17987,A6NIH7	10
Transcriptional regulation by tp53	0.242688395891069	1.0617959518954123	0.2883283279498223	1.0	0.4191965223975137	117	P30153,P00390,Q9Y5B9,P43246,Q99873,Q9UQ84,P63104,Q16881,Q13625,P27694,P24941,Q8TBX8,Q15382,Q9NQ88,P14635,P32780,P12004,P62258,P27348,P30154,P42771,Q00535,P55199,Q15370,P49327,P54646,Q12962,P06493,Q13526,Q07812,Q04917,P61981,P23193,P15927,O96017,P40937,O14965,Q8IXH7,P54132,P51530,P18074,O14744,P40938,Q9H3P2,P54619,P06744,P35269	47
Platelet sensitization by ldl	0.5317454992533226	1.0606571675134362	0.2888457321510054	1.0	0.4195140395526507	5	P30153,Q06124,Q14738	3
Met promotes cell motility	0.4819620281674261	1.0564868785744932	0.2907458324886542	1.0	0.4214012427495681	8	P62993,P46108,P07942,P46109	4
Suppression of apoptosis	0.5305994349180642	1.055234702106383	0.2913179967619737	1.0	0.4217947878813716	5	P27361,P28482,P49840	3
Metabolism of cofactors	0.5289017789446564	1.0472058302165146	0.2950046569005748	1.0	0.4266923027128933	5	P00374	1
Pka mediated phosphorylation of key metabolic factors	0.3819857312722851	1.030910133827799	0.3025829639566728	1.0	0.4341638340374233	2	P17612	1
Hdl assembly	0.3819857312722851	1.030910133827799	0.3025829639566728	1.0	0.4341638340374233	2	P17612	1
Gap junction trafficking and regulation	0.4475290223854603	1.0193031232157297	0.308059081714195	1.0	0.4410274404540976	10	P04350,Q13885,Q9BUF5	3
Glutathione conjugation	0.3875803939097281	1.0066506681514684	0.3141026765025509	1.0	0.447851682045812	16	Q8WUX2,P14550,P48506,Q96KP4,O75223,P21266,P78417,P28161	8
Mrna decay by 3 to 5 exoribonuclease	0.3926839145514816	1.0053193874466375	0.3147430825370012	1.0	0.4483091825374748	15	Q9GZS3,Q6PGP7,Q9Y2L1,Q96C86,Q15477	5
Sensory processing of sound by outer hair cells of the cochlea	0.4009319271264178	0.9968108121864592	0.3188563490950975	1.0	0.4532476775890798	14	Q00013,P26038,Q12792,Q6IBS0,Q14651,P15311	6
Translation	0.2141306765686384	0.9879241222331084	0.3231898106103901	1.0	0.4570920406112674	222	P26640,Q9UHB9,P42766,P25398,P47897,P62861,P62854,P13639,P14868,P15880,P30050,P60842,P61011,Q9P2J5,P46777,P46782,P07814,Q05639,P62857,P27635,P41252,P62888,Q13144,P61513,O60841,P49589,P41250,P32969,P29692,Q9Y285,P18621,P62910,P62249,P56192,P23381,Q14232,Q9P015,P62495,P62899,Q9NVS2,P62851,P46781,P46783,P60059,P62273,Q15056,Q15181,P62841,Q9NR50,P62913,P62847,P08708,P26641,O76094,P11940,P49770,P62906,P62829,P62269,Q14240,P06730,Q14152,P62081,P35268,P24534,P39019,P62750,P62701,P60866,P63173,P23396,O43776,O00303,P15170,O15372,P55884,O43324,P54136,O75821,O75822,P37108,P26639,P49591,P55010,Q04637,P54577,Q9Y262,Q15046,O15371,P05388,P08865,P13798,P62266,P49588,P62753,Q5JPH6,Q13347,Q9NSD9,P05198,P62277,P62244,P61247,P09132,P60228,P23588,P46778	106
Gpvi mediated activation cascade	0.4990074930296516	0.9796922874453556	0.3272380343152563	1.0	0.4614220725068388	6	O00459	1
Ncam signaling for neurite out growth	0.4828729797295414	0.9766408447199898	0.328746990613439	1.0	0.4630843652918223	7	P27361,P28482	2
Dna double strand break repair	0.2682160184462142	0.97531541263657	0.329403827538373	1.0	0.463256265136905	53	P18887,Q04323,Q9UQ84,P53041,P27694,P24941,Q9NY27,P09874,P49005,P12004,Q9NRF9,P56282,P15927,P61088,O96017,P40937,P54132,P51530,P13010,P40938,P28340,P39748	22
Signaling by insulin receptor	0.3828870327286738	0.9750622085199804	0.3295294031408633	1.0	0.463256265136905	16	P62993,P27361,Q9UI12,P28482,P21283,Q06124,Q9Y5K8,O00459	8
Copi dependent golgi to er retrograde traffic	0.277512532868256	0.9663522894508596	0.3338679292418365	1.0	0.4670220466683524	47	Q86Y91,P61923,Q9H0H5,Q9NP61,Q12981,P53618,Q07866,Q13885,P35606,Q9UBF2,O14579,P62820,P48444,Q9Y678,P18085,P53621,P52732,Q92538,P33176,Q8N6T3,P04350,Q9BUF5,Q99661	23
Toll like receptor 9 tlr9 cascade	0.3513053366341247	0.966343158658026	0.3338724966559925	1.0	0.4670220466683524	21	P30153,P27361,P09429,Q14738,P28482,P63208,P61088,P51452,Q02750	9
Pecam1 interactions	0.5058116201674844	0.9385182972869052	0.3479781183542407	1.0	0.4829013848180017	5	P06756	1
Constitutive signaling by overexpressed erbb2	0.4620655723752727	0.9335170766402812	0.3505530576904112	1.0	0.4855142546294639	4	Q16543,P07900	2
Crmps in sema3a signaling	0.4889970928354733	0.9309843056237846	0.3518616826066105	1.0	0.4868460953620064	6	Q16555,Q14195,Q00535	3
Activation of rac1	0.4886092036632355	0.9291024400063076	0.3528360000845736	1.0	0.4876957622410423	6	Q16512,Q9Y6N7,Q13177,O96013	4
L1cam interactions	0.2770047406066143	0.9205675340570446	0.3572762589082554	1.0	0.4914299914198847	45	P06756,Q16555,P35241,P07942,Q16512,Q13885,Q96P70,P27361,P28482,P26038,P36507,P15311,P11142,Q12959,P50570,P04350,Q9BUF5,Q15334,Q02750	19
Regulation of tp53 activity through methylation	0.4106720441403928	0.915428973008604	0.3599664740430597	1.0	0.4941614120180164	3	O14744	1
Regulation of commissural axon pathfinding by slit and robo	0.363258026159323	0.912012659470782	0.3617620534492809	1.0	0.496140919833178	2	Q9Y6N7	1
Hdr through single strand annealing ssa	0.4068600048107245	0.9080171663190788	0.363869152145984	1.0	0.4974062208666334	12	P54132,P51530,Q9UQ84,P15927,P40938,P27694	6
Homologous dna pairing and strand exchange	0.4068600048107245	0.9080171663190788	0.363869152145984	1.0	0.4974062208666334	12	P54132,P51530,Q9UQ84,P15927,P40938,P27694	6
Runx2 regulates bone development	0.4969991124308993	0.8973686093482353	0.3695222570514378	1.0	0.5043188002365441	5	P06400,P28482	2
Rho gtpases activate iqgaps	0.4155057213884856	0.8964436780561827	0.3700158483189311	1.0	0.5044761690131245	11	Q86VI3,P04350,Q13885,Q9BUF5	4
Metabolism of carbohydrates	0.2387735563625601	0.8958054046598029	0.370356702839286	1.0	0.5044761690131245	99	P30153,P11908,P06737,P36871,P52209,P17174,P08237,P00558,P46976,Q14738,Q01813,P09104,P09972,O43252,P37837,P60174,Q00796,O75330,P29401,P11166,P14618,P51570,P18669,P04075,P06733,P04406,P11216,P35573,P06744,A6NDG6,O95336	31
Telomere maintenance	0.2758431094557736	0.8906687228542002	0.3731069189848899	1.0	0.5070276936860229	44	Q14181,P09884,P54132,P51530,Q9NPE3,P49005,P12004,P18858,Q8WVB6,P49643,P15927,P40938,P27694,P28340,P49642,P39748	16
Ripk1 mediated regulated necrosis	0.4033062296317334	0.8868343547177762	0.3751680884612587	1.0	0.5079878903685779	12	P49327,Q9UNE7,Q13546,P07900,Q16543	5
Raf activation	0.4203332383834041	0.8660545668330883	0.3864602386133464	1.0	0.5188552294493063	10	P30153,P36507,Q02750,Q14738	4
Interferon gamma signaling	0.3887907526877447	0.8643640984304009	0.387387908509035	1.0	0.5196034757535145	13	Q14258,Q06124,P19474,P29372	4
Metabolism of water soluble vitamins and cofactors	0.2813722861426752	0.8522552166569404	0.3940724560049742	1.0	0.5275607402433005	39	P49327,Q96CD2,Q13085,P00374,Q9NQX3,Q13057,P50747,P11166,P78417,P11586,Q99707,Q9NRN7,Q9H2D1,P34896,O95396,O00763,P43490	17
Darpp 32 events	0.4166196367098149	0.8453850707476482	0.3978958772058227	1.0	0.5311588160987339	10	P30153,P30154,Q14738	3
Mitotic prometaphase	0.236153752561696	0.8416517896048354	0.3999828911692407	1.0	0.5329306707601564	89	P30153,Q13561,P07437,Q8NBT2,Q7Z4H7,P61163,Q15691,Q9H6D7,Q15003,Q9BPX3,Q13409,O60566,P50748,P63167,Q14738,Q15021,Q14204,Q9NTJ3,P14635,Q9Y6G9,Q9HC35,P62258,P30154,P17612,O95347,Q13885,O94927,Q8NFH4,O43237,Q96CW5,P06493,P07900,P61981,Q15154,Q9BSJ2,P43034,Q7Z5K2,P23258,Q7Z460,Q12834,Q9P258,Q14008,P04350,Q14203,Q9Y266,Q9BUF5,Q99661	47
Downregulation of erbb2 signaling	0.4691167846129379	0.8351852304317148	0.4036134242269917	1.0	0.5372577174482632	6	P07900,Q9UNE7	2
Signaling by receptor tyrosine kinases	0.2235629682974086	0.832184023088103	0.405305080614734	1.0	0.5384289450774423	125	P30153,O43865,P06756,Q9UI12,Q9UBC2,Q96J02,Q9Y5K8,P21281,Q16543,Q9Y6W5,Q14738,Q9UNE7,P07942,P21283,P46108,P42566,P30154,P61201,Q93034,Q00535,Q96JJ3,Q16512,O00459,P51452,Q96P70,P27361,P46109,Q9UQB8,P28482,Q07812,P07900,P46934,P36507,Q06124,Q13177,O75886,P04792,P62993,P50570,P41240,O14964,O60610,Q96N67,Q96F07,P42224,Q15334,Q02750,P35269	48
Advanced glycosylation endproduct receptor signaling	0.4238276437466081	0.8320925956466958	0.4053566809016007	1.0	0.5384289450774423	9	P27361,P09429,P47755,P28482,P52907	5
Initiation of nuclear envelope ne reformation	0.3612723710109563	0.8312618700501958	0.4058257099297364	1.0	0.5384289450774423	16	Q99986,P06493,P63151,Q14739	4
Rho gtpases activate rocks	0.4140093534705594	0.8309030778017105	0.4060283848124975	1.0	0.5384289450774423	10	P60660,O14974,P23528,P35579,Q16512	5
Integrin signaling	0.4815082290489042	0.8256455840248685	0.4090051688837008	1.0	0.54059750066208	5	P62993,P46108,Q9Y490	3
Platelet aggregation plug formation	0.4815082290489042	0.8256455840248685	0.4090051688837008	1.0	0.54059750066208	5	P62993,P46108,Q9Y490	3
Transcription of the hiv genome	0.296875565746804	0.8237289615388216	0.4100935795899514	1.0	0.5412617988379133	30	Q8IXH7,P32780,P18074,Q12962,P23193,Q9H3P2,P55199	7
Downregulation of smad2 3 smad4 transcriptional activity	0.4642280222332732	0.8118647700253433	0.4168692315682292	1.0	0.5496875299720165	6	Q96PU5,P09874,Q9UPN9	3
Costimulation by the cd28 family	0.3626517070148164	0.8092657951614222	0.418362276475007	1.0	0.5511382853468871	15	P30153,P62993,Q14738,Q06124,Q13177,P30154,Q16512,O00459	8
Aspartate and asparagine metabolism	0.4764886865897161	0.8026039231033192	0.4222037001076004	1.0	0.5556771024868324	5	P17174	1
Phosphorylation of the apc c	0.3987362782624484	0.8004024189981384	0.4234776799305582	1.0	0.5561625363816244	11	Q16763	1
Striated muscle contraction	0.4757512645046247	0.7992280828275916	0.4241581710109323	1.0	0.5561625363816244	5	P11532,P08670,P06753,P67936	4
Unwinding of dna	0.3961169206052714	0.7855655341622119	0.4321220629513664	1.0	0.5650207402803049	11	P33991,P25205,Q9BRX5,P49736,Q9Y248,Q9UJA3,Q9BRT9	7
Class b 2 secretin family receptors	0.3861607730122122	0.7790613968951065	0.4359435486041272	1.0	0.5689570220386888	3	P48960	1
Nephrin family interactions	0.4120942140408907	0.7693347415404713	0.4416946180860277	1.0	0.5737940270136083	9	Q9Y5K6,O00459,Q96J84	3
Negative regulators of ddx58 ifih1 signaling	0.4254517761985121	0.7616930414259682	0.4462432294312632	1.0	0.5780971845725414	8	Q14258,Q96J02,P61086,Q15366	4
Regulation of tp53 activity	0.2527422627507826	0.757957859408077	0.448476210722549	1.0	0.5783110550570244	50	P30153,Q9Y5B9,Q9UQ84,Q13625,P27694,P24941,Q8TBX8,P30154,P42771,Q00535,P54646,P06493,Q12962,Q13526,P15927,O96017,P40937,O14965,P54132,P51530,O14744,P40938,P54619	23
Inositol phosphate metabolism	0.4527645980908431	0.7576340313989451	0.4486701012749334	1.0	0.5783110550570244	6	P29218,Q9NPH2	2
Plasma lipoprotein assembly	0.3820993160868354	0.7568196572476645	0.4491579143523481	1.0	0.5783110550570244	3	P07237,P17612	2
Robo receptors bind akap5	0.3820993160868353	0.7568196572476638	0.4491579143523485	1.0	0.5783110550570244	3	P17612,P13861	2
Role of abl in robo slit signaling	0.4267446148210918	0.7565930738827622	0.4492936920970467	1.0	0.5783110550570244	4	Q9Y6N7,Q01518	2
Dissolution of fibrin clot	0.3809099018733349	0.7503290135786645	0.4530565725954343	1.0	0.5808080062126	3	P60903,P35237	2
Tbc rabgaps	0.337363795109614	0.7411769719013501	0.458586144082473	1.0	0.5854379983145674	18	Q9UJY5,Q92930,Q8TC07,P60520,Q9NVG8	5
Metabolism of steroids	0.2622515927427434	0.7389789678540163	0.459919768754911	1.0	0.5866067596028547	43	Q9UBM7,Q14739	2
Hiv transcription elongation	0.2963926891380101	0.7375438537070356	0.4607916849589037	1.0	0.5866522087090218	26	Q8IXH7,P32780,P18074,P23193,Q9H3P2,P55199	6
Recycling pathway of l1	0.3190767401134298	0.7296623645969641	0.4655965913012836	1.0	0.591695668112048	21	P28482,P26038,P04350,Q16555,Q9BUF5,Q13885,P15311	7
Tak1 activates nfkb by phosphorylation and activation of ikks complex	0.4322680677074088	0.7251847162180634	0.4683387178817395	1.0	0.5946418291294847	7	P61088	1
Sema4d in semaphorin signaling	0.4298191554689319	0.713356823365346	0.4756249835222588	1.0	0.6022579890629324	7	P60660,P35579,O75116	3
Ddx58 ifih1 mediated induction of interferon alpha beta	0.3278204058783487	0.7125652319710027	0.476114832562982	1.0	0.6023346348835561	19	P09429,Q13546,P61086,P07900,Q96J02,P08238,Q14258,Q15366	8
Rhou gtpase cycle	0.3276197408809161	0.7112027703982843	0.4769585920755397	1.0	0.6024096977487007	19	P62993,P46940,O14964,Q13177,O75886,Q16512,O00459	7
Nuclear events kinase and transcription factor activation	0.3797998995461865	0.6943924524093915	0.4874361257122026	1.0	0.6141700075312443	11	P30153,P27361,Q14738,P28482,P30154,P51452	6
Trna modification in the mitochondrion	0.4257219410538919	0.6936619422310699	0.4878942382753477	1.0	0.6141700075312443	7	O15091,Q99714,Q9Y2Z2,Q9Y606,Q969Y2,O75648	6
Signaling by erbb2	0.3776145693310367	0.6823667148272919	0.4950070972740978	1.0	0.6217501857435624	11	P62993,Q9UNE7,P07900,O60610,Q16543	5
Copii mediated vesicle transport	0.2794844289483734	0.6770042622337752	0.4984032500854711	1.0	0.6237821229883282	30	Q13190,O94979,Q92734,O15027,O15498	5
Regulation of ifna signaling	0.3668063293030479	0.6742550399677885	0.5001491826306852	1.0	0.6248524516748454	3	Q06124	1
Regulation of ifng signaling	0.3668063293030479	0.6742550399677885	0.5001491826306852	1.0	0.6248524516748454	3	Q06124	1
Asparagine n linked glycosylation	0.2130187578580015	0.6714332176531072	0.5019445896394505	1.0	0.626537597210097	125	P62191,Q04323,P47755,P61923,P61163,P52907,Q13190,Q92734,O15498,Q14746,Q9Y6G9,Q16222,Q13630,P54727,Q9H9E3,P35606,O43237,O14579,O94979,P48444,P18085,Q9Y678,Q9NR45,Q9UJW0,Q9NYU1,Q14203,Q9BUF5,O15027	28
Metalloprotease dubs	0.408387864366458	0.6674028238844661	0.5045148626192408	1.0	0.62910792076252	4	O00487,Q9NWV8,Q9NXR7	3
Assembly of the orc complex at the origin of replication	0.4065307320581118	0.6667989185920269	0.5049005835913025	1.0	0.62910792076252	8	Q9UBD5,Q13416	2
Translocation of slc2a4 glut4 to the plasma membrane	0.2659711658680651	0.6647109322037416	0.506235400168225	1.0	0.6291905826927521	36	O60645,P54646,O60343,Q04917,P61981,P27348,P35579,Q8TAG9,P04350,Q9BUF5,Q86TI0,Q13885,P54619,Q86X10,P63104	15
Apc c cdc20 mediated degradation of cyclin b	0.3700079461550521	0.6409003059024092	0.5215874571092152	1.0	0.6441788752854127	11	Q16763	1
Tight junction interactions	0.3180737217598008	0.6348554756975057	0.5255226780886568	1.0	0.6478983456576323	2	Q8NI35	1
Interleukin 35 signalling	0.3589057389235909	0.6324562809763616	0.5270887676168767	1.0	0.6482568813526156	3	P42224,P40763	2
Interleukin 27 signaling	0.3589057389235909	0.6324562809763616	0.5270887676168767	1.0	0.6482568813526156	3	P42224,P40763	2
Rrna processing in the mitochondrion	0.42559523809524	0.6322865590975243	0.5271996447778577	1.0	0.6482568813526156	6	O15091,Q99714,Q9BQ52,Q9HC36,Q8WVM0	5
Cargo recognition for clathrin mediated endocytosis	0.2629111798050574	0.6268619264718533	0.5307497463750497	1.0	0.6520506954152318	35	P62993,Q99627,Q7L5N1,O14964,Q9UBC2,Q9H9Q2,Q2M2I8,Q9UBW8,P61201,P42566,Q9UNS2,Q9BT78,P20645,Q13098,Q9NVZ3,Q92905	16
Regulation of lipid metabolism by pparalpha	0.3094544550829065	0.6243551836998213	0.5323943504411124	1.0	0.6534989270943838	20	P23786	1
Suppression of phagosomal maturation	0.4105921253974978	0.6220676734466208	0.5338973702226988	1.0	0.6537803016609033	7	P52294,O14964	2
Erk mapk targets	0.3973518926118113	0.6218348451218852	0.5340504713000866	1.0	0.6537803016609033	8	P30153,P27361,Q14738,P28482,P51452	5
Mapk targets nuclear events mediated by map kinases	0.3973518926118113	0.6218348451218852	0.5340504713000866	1.0	0.6537803016609033	8	P30153,P27361,Q14738,P28482,P51452	5
Dual incision in tc ner	0.25960499401721	0.6211703723321982	0.534487531008593	1.0	0.6537803016609033	37	P49005,P32780,P12004,P18074,Q9NRF9,P15927,P23193,P40938,P56282,P27694,P28340,P40937,Q9ULR0	13
Scavenging by class f receptors	0.398137902295371	0.6187394217157522	0.5360880354246982	1.0	0.6551668237812296	4	P07900	1
Trafficking of ampa receptors	0.3639344262295091	0.6082664285676221	0.543010783007178	1.0	0.6630497202428813	11	P17252,O95782,Q96CW1,Q12959,P63010,Q13555,P53680,Q9UM54,P46459,Q15334	10
Sema4d induced cell migration and growth cone collapse	0.4169748594458846	0.5936820836464928	0.5527247684480734	1.0	0.6737383580648539	6	P60660,P35579	2
Diseases of carbohydrate metabolism	0.3907074446057318	0.5897989462380183	0.5553254492505979	1.0	0.6763208379328028	8	P46976	1
Signaling by scf kit	0.3682118537964417	0.5855266486496047	0.5581936534721783	1.0	0.6786357849406119	10	O00459	1
Cell extracellular matrix interactions	0.4007363143078517	0.5765249591472982	0.5642604044374089	1.0	0.6848246950049175	7	Q14315,Q15404,P12814,Q96AC1	4
Rab regulation of trafficking	0.2525315713082041	0.5726245440204024	0.5668989375944886	1.0	0.6867178483651457	38	P20339,P50395,P60520,Q4KMP7,P62258,Q9H2M9,Q9UJY5,P61020,Q92930,Q7Z392,P62330,O43617,Q8TC07,P62820,P31150,Q14C86,Q9NVG8,Q9Y3P9,Q14964,Q9Y296	20
Stimuli sensing channels	0.3737590111363876	0.5720491793804511	0.5672886573451204	1.0	0.6867178483651457	9	Q13546	1
Glucagon like peptide 1 glp1 regulates insulin secretion	0.4114031619520679	0.5690859855493168	0.5692977885679091	1.0	0.6880048245209698	6	P46940,Q9UBI6,P17612	3
Vitamin b5 pantothenate metabolism	0.4084666900755362	0.5562432855763616	0.5780445521808919	1.0	0.6979315892511113	6	Q9NRN7,Q13057,P49327,Q96CD2	4
Dag and ip3 signaling	0.3826682549136333	0.5516781454900076	0.5811688857698629	1.0	0.7004982360267334	8	O43865,P13861,P19174,Q13555,P10644,P52292,P17612	7
Rap1 signalling	0.3822129684711549	0.5451178083441103	0.5856724954154338	1.0	0.7015143184052018	4	P31946,P17612,P63104	3
Creb1 phosphorylation through the activation of adenylate cyclase	0.3822129684711509	0.5451178083440922	0.5856724954154462	1.0	0.7015143184052018	4	P10644,P17612,P13861	3
Pka mediated phosphorylation of creb	0.3822129684711509	0.5451178083440922	0.5856724954154462	1.0	0.7015143184052018	4	P10644,P17612,P13861	3
Pka activation in glucagon signalling	0.3822129684711509	0.5451178083440922	0.5856724954154462	1.0	0.7015143184052018	4	P10644,P17612,P13861	3
Long term potentiation	0.4177328176138198	0.5438975556450601	0.5865119711256606	1.0	0.7015143184052018	5	Q14168,Q15334,P07196,Q12959	4
Ras activation upon ca2 influx through nmda receptor	0.4177328176138198	0.5438975556450601	0.5865119711256606	1.0	0.7015143184052018	5	Q14168,Q15334,P07196,Q12959	4
Unblocking of nmda receptors glutamate binding and activation	0.4177328176138198	0.5438975556450601	0.5865119711256606	1.0	0.7015143184052018	5	Q14168,Q15334,P07196,Q12959	4
Negative regulation of nmda receptor mediated neuronal transmission	0.4177328176138198	0.5438975556450601	0.5865119711256606	1.0	0.7015143184052018	5	Q14168,Q15334,P07196,Q12959	4
Signaling by erbb2 in cancer	0.4152479288046759	0.5335519591112088	0.5936515534269557	1.0	0.7079356203303713	5	Q16543,P07900	2
Signaling by erbb2 ecd mutants	0.4152479288046759	0.5335519591112088	0.5936515534269557	1.0	0.7079356203303713	5	Q16543,P07900	2
Signaling by hippo	0.4029761904761925	0.5324656365421114	0.594403535815522	1.0	0.7079356203303713	6	P62258,P31946,Q07157,Q13188,Q4VCS5	5
The role of nef in hiv 1 replication and disease pathogenesis	0.3378385321235452	0.516239503015344	0.6056871433035895	1.0	0.7194050003199667	12	Q10567,Q9BXS5	2
Interconversion of nucleotide di and triphosphates	0.3108611543931059	0.5156368216436447	0.6061080878871437	1.0	0.7194050003199667	16	P00390,P33316,P23919,Q16881,P27144,P23921,P31350,P17812,P04818,P15531,P30085	11
Activation of nmda receptors and postsynaptic events	0.2771411106937086	0.5149365288933044	0.6065973737551822	1.0	0.7194050003199667	23	P27361,Q12959,P54646,P28482,P04350,Q9BUF5,Q13885	7
Sars cov 1 infection	0.314283885693279	0.5132611154951272	0.6077686801486606	1.0	0.7194860482635341	15	Q9Y3E7,P49841,Q8WUX9,Q9H444,P55072,P49840,P06400,Q9UQN3	8
Perk regulates gene expression	0.3140470576605793	0.5119057243910299	0.6087169916527548	1.0	0.7194860482635341	15	Q9Y2L1,P08243	2
Esr mediated signaling	0.2358583911676313	0.5072230221024783	0.6119983432211973	1.0	0.7227556191408584	44	P04792,P27361,Q02790,P28482,P07900,P53041,Q13451,P08238,O00459	9
Fceri mediated mapk activation	0.3715237406417795	0.5001227685884835	0.6169886349788816	1.0	0.7280362109969477	8	P62993,P27361,P28482,Q13177	4
Hiv elongation arrest and recovery	0.2800379558934111	0.4984085829796414	0.6181960884253075	1.0	0.7288264265071229	22	Q15369,O00267,Q9Y5B9,Q8WX92,Q15370,Q8IXH7,Q08945,P23193,Q9H3P2,P52434,P55199,Q9Y5B0,Q14241,P35269	14
Transcriptional regulation of white adipocyte differentiation	0.3253354115889043	0.4959953727380494	0.619897675642864	1.0	0.7296278850058207	13	Q96EK7,Q71SY5,P11802,P24468	4
Ca dependent events	0.3825543316463402	0.4952247752028749	0.6204414640368758	1.0	0.7296558038924869	7	P13861,Q13555,P10644,P28482,P52292,P17612	6
Rna polymerase iii transcription initiation from type 3 promoter	0.3671299203542023	0.4802486571127334	0.6310505922015031	1.0	0.7402708870056094	8	Q9H1D9	1
Rna polymerase iii chain elongation	0.3671299203542023	0.4802486571127334	0.6310505922015031	1.0	0.7402708870056094	8	Q9H1D9	1
Glycolysis	0.2222634979439793	0.4697469368594303	0.6385358294412069	1.0	0.7484258719348482	51	P30153,P04075,Q14738,P06733,P04406,P14618,Q01813,P09104,A6NDG6,P09972,P18669,P08237,P06744,P60174,P00558	15
Retrograde neurotrophin signalling	0.3636092912447863	0.4645222200427995	0.6422736436318384	1.0	0.7515512277026433	8	O95782,Q96CW1,P63010,P50570,Q00610,P09496,P53680	7
Inactivation of cdc42 and rac1	0.363474122546101	0.4622175390200674	0.643925326904045	1.0	0.7522291703966487	4	Q9Y6N7,P60953,P63000	3
Signaling by csf3 g csf	0.3614313746160801	0.4548850791717015	0.6491919178434571	1.0	0.7571207487401249	8	P62993,Q15370,Q06124,Q93034,P42224	5
Aquaporin mediated transport	0.3824404761904784	0.4465564002117688	0.6551953816695106	1.0	0.7628540418940443	6	P13861,P10644,Q9UBI6,P17612,Q99797	5
Processing of dna double strand break ends	0.2611059516873	0.443691920684357	0.6572653375265354	1.0	0.7646295759118815	24	Q9UQ84	1
Tp53 regulates metabolic genes	0.2456219438666029	0.440121955912859	0.6598487807109314	1.0	0.7667991733446986	32	P00390,P54646,Q16881,P27348,Q15382,Q9NQ88,P06744,P63104,P54619	9
Gap junction degradation	0.3912526033918596	0.437050334661174	0.6620748445775706	1.0	0.7683134879589177	5	Q00610,Q9UM54,P50570,P09496	4
Smooth muscle contraction	0.3285877973357267	0.428941262913198	0.6679659705379868	1.0	0.773869741259121	11	P60660,Q9Y490,Q13177,Q05682,P18206,Q16512	6
Negative regulation of met activity	0.3546120695561704	0.4251825767388621	0.6707035844309106	1.0	0.7747761010861073	8	P62993,O14964,P42566,O75886	4
Rho gtpases activate ktn1	0.3770788917977398	0.4250022247357926	0.6708350529448885	1.0	0.7747761010861073	6	P84095,P33176,Q07866	3
Rhod gtpase cycle	0.2467092174729664	0.4248042184946261	0.6709794022111997	1.0	0.7747761010861073	30	O00459,Q14739	2
Glucagon signaling in metabolic regulation	0.3823266884855857	0.4029202638583429	0.6870068836175311	1.0	0.7913552197991759	5	P10644,Q9UBI6,P13861,P17612	4
Vasopressin regulates renal water homeostasis via aquaporins	0.3823266884855857	0.4029202638583429	0.6870068836175311	1.0	0.7913552197991759	5	P10644,Q9UBI6,P13861,P17612	4
Tp53 regulates transcription of dna repair genes	0.2433394387728519	0.4013493314181955	0.6881629482942553	1.0	0.791458258672634	30	Q8IXH7,P43246,P32780,P18074,P23193,Q9H3P2,P55199,P35269	8
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.3301549463647127	0.4012656201042009	0.6882245727588121	1.0	0.791458258672634	10	O94973,O95782,Q96CW1,P63010,Q9BXS5,Q9UI12,O43747,P53680,Q10567	9
Opioid signalling	0.2781606514429785	0.3996906734870996	0.6893843623077709	1.0	0.7921427193429996	19	O43865,P30153,Q14738,P28482,P30154	5
Prevention of phagosomal lysosomal fusion	0.3447352766210523	0.3842340567674133	0.7008049784164458	1.0	0.8015442663543959	4	P20339,O14964,Q9H267	3
Nef mediated cd4 down regulation	0.3633928571428593	0.3718453551629658	0.7100079925442082	1.0	0.809213008561758	6	O95782,Q96CW1,P63010,Q9UI12,P53680	5
Nef mediated cd8 down regulation	0.3633928571428593	0.3718453551629658	0.7100079925442082	1.0	0.809213008561758	6	O95782,Q96CW1,P63010,Q9UI12,P53680	5
Netrin 1 signaling	0.321379782824467	0.3624440584307806	0.7170202204810747	1.0	0.8158794560705173	10	Q9Y6N7,P19174,Q06124,Q16512,P15311,P63000	6
Formation of the early elongation complex	0.2697278171869949	0.3530628813486171	0.724041299557282	1.0	0.8205411496598276	19	P18074,Q8IXH7,Q9H3P2,P32780	4
Sensory perception	0.2397828808627183	0.3456622449277392	0.7295965613140112	1.0	0.8255032060673853	27	P47755,Q00013,P26038,P52907,Q12792,P15311	6
Rhoc gtpase cycle	0.2277754171631489	0.3399674858611985	0.7338810136263691	1.0	0.828346791727913	34	P63167,Q5T8D3,Q14739,P46940,Q9H2G2,Q9NSV4,O60610,Q13190,Q16513,P49257,P11274,Q16512,Q9H0H5,Q86VI3,P52565	15
G0 and early g1	0.3438032060482892	0.3370299419374717	0.7360943288030177	1.0	0.8295103159121557	7	P06493	1
Regulation of tp53 expression and degradation	0.3073368813401418	0.3323861338134558	0.7395977075537401	1.0	0.8317784237198275	11	P30153,P06493,P30154,P42771,O96017	5
Thrombin signalling through proteinase activated receptors pars	0.362756389939825	0.3320048683722119	0.7398855828954702	1.0	0.8317784237198275	5	P28482	1
Kinesins	0.2693841431943869	0.330398747991978	0.7410986874267345	1.0	0.832475146885275	18	Q86Y91,P52732,P33176,P04350,Q07866,Q9BUF5,Q9H0H5,Q13885,Q99661,O95239	10
Flt3 signaling in disease	0.3408752604942009	0.3260832851990202	0.7443613429563416	1.0	0.8341365528496384	7	P62993,P22681,Q15643,Q06124,Q14789,Q01082	6
Chromosome maintenance	0.205181313540454	0.3179935253959374	0.7504898481919493	1.0	0.8396628843806259	49	Q14181,P09884,P54132,P51530,Q9NPE3,P49005,P12004,P18858,Q8WVB6,P49643,P15927,P40938,P27694,P28340,P49642,P39748	16
Amino acids regulate mtorc1	0.2877734172857103	0.3108054299071087	0.7559485415250551	1.0	0.8429031339406321	13	Q9UI12,Q15382,Q9Y5K8,P21283	4
Signaling by kit in disease	0.3464724179079471	0.3102249330742329	0.756389911355136	1.0	0.8429031339406321	6	P62993,O00459	2
Atf4 activates genes in response to endoplasmic reticulum stress	0.2870113064431174	0.307421158801136	0.7585228250533325	1.0	0.8444709286381004	13	Q9Y2L1	1
Listeria monocytogenes entry into host cells	0.3242612076791743	0.3028557711627745	0.761999778778532	1.0	0.8456015938932575	8	P62993,O14964,P42566,O75886	4
Rhobtb gtpase cycle	0.2293604856298675	0.3027283854357017	0.7620968637733303	1.0	0.8456015938932575	29	P40227,P78371,Q5VTR2,P07900,Q12792,Q99832,Q9BT78,P08238,Q16543,Q13098	10
Regulation of cholesterol biosynthesis by srebp srebf	0.2364961834038331	0.3022943741615493	0.7624276666250682	1.0	0.8456015938932575	25	P49327,P53602,Q13085,Q9UBM7,P48449,P62826,P14324,Q13907,O95487,O00763,Q15126	11
Deactivation of the beta catenin transactivating complex	0.3125765750157094	0.2989081418945295	0.7650101346286624	1.0	0.8477955915355556	9	Q15291,Q9HCK8,Q04726,Q13363,P63104	5
Factors involved in megakaryocyte development and platelet production	0.2046714550916281	0.2948484479056931	0.7681096546223025	1.0	0.8498878907216801	47	P47755,Q86Y91,P20339,P47756,P52907,Q9NRW7,Q9H0H5,P24941,P63000,Q96HP0,P27144,Q07866,P17612,Q00535,Q13885,O95239,Q9H4M9,Q13547,P10644,P52732,P33176,Q96N67,P04350,Q9BW19,Q9BUF5,Q99661	26
Hdr through mmej alt nhej	0.3184331742889661	0.2814501000843808	0.7783651960745848	1.0	0.8585270205130837	8	P18887,P39748	2
Rhoj gtpase cycle	0.2427911868139843	0.277672392938462	0.7812638547502488	1.0	0.8610472806084832	22	O00459	1
Signaling by wnt in cancer	0.3032705487138715	0.2639062049465691	0.7918521942468606	1.0	0.8699832643135046	9	P30153,P49841,P30154,Q14738	4
Signaling by flt3 fusion proteins	0.3406724189229456	0.2593241382147654	0.7953851566660959	1.0	0.8729979899680123	5	P62993,Q01082,Q15643,Q14789	4
Detoxification of reactive oxygen species	0.293719550810198	0.251480903210931	0.8014423249129776	1.0	0.8769206452535336	10	P00390,P30041	2
Fgfr1 mutant receptor activation	0.2895871472873673	0.236551883033511	0.81300445252079	1.0	0.8849070961106814	10	P62993,P11274,O95429	3
Rho gtpases activate formins	0.1872364449142408	0.2328933128321132	0.8158442512711419	1.0	0.8866223737671666	55	P30153,Q8NBT2,Q15691,Q13409,O60566,P50748,Q14204,Q14738,P35080,P63167,Q9Y6G9,P30154,Q13885,P07737,Q8NFH4,O43237,P43034,Q12834,Q9P258,Q14008,O60610,P04350,Q9Y266,Q9BUF5	24
Hur elavl1 binds and stabilizes mrna	0.3217242057992414	0.2294348711542684	0.8185309356552153	1.0	0.8881662047364788	6	P39687	1
Cd28 co stimulation	0.2921081897683593	0.2247290190686622	0.8221900880194384	1.0	0.8914472128989738	9	P62993,O00459,Q13177	3
Nicotinate metabolism	0.2670234909307248	0.2207317878895563	0.8253012787190597	1.0	0.8934395787367598	3	Q4G0N4,P43490	2
Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways	0.264926677650816	0.2170235319510509	0.8281900061085496	1.0	0.8958755424597495	13	P61088	1
Signaling by ctnnb1 phospho site mutants	0.304964077833934	0.2057875316902332	0.8369568810266754	1.0	0.901952414421912	7	P30153,P30154,Q14738	3
Disassembly of the destruction complex and recruitment of axin to the membrane	0.304964077833934	0.2057875316902332	0.8369568810266754	1.0	0.901952414421912	7	P30153,P30154,Q14738	3
Beta catenin phosphorylation cascade	0.304964077833934	0.2057875316902332	0.8369568810266754	1.0	0.901952414421912	7	P30153,P30154,Q14738	3
Pi metabolism	0.2352712505423715	0.2048811272593824	0.8376650007068789	1.0	0.901952414421912	20	O00459	1
Metabolism of vitamins and cofactors	0.1844087301599073	0.1940324728100067	0.8461504554366228	1.0	0.906220678608841	50	P00374,P50747	2
Rac2 gtpase cycle	0.1918713711980451	0.1753042006299277	0.8608406112578657	1.0	0.9156629094729232	40	Q14739	1
Interleukin 4 and interleukin 13 signaling	0.259093619558724	0.1744554251784931	0.8615075590759917	1.0	0.9156781101391032	12	P05556,P04637,P04083,P09601,Q16658,P07900,P08670,Q07820,P42224,P11142,P40763	11
Signaling by fgfr1 in disease	0.2636128904916079	0.170024837201918	0.8649906037710335	1.0	0.91868419159028	11	P62993,P11274,O95429	3
Cell surface interactions at the vascular wall	0.2264074058916897	0.1691547756666595	0.8656749008879936	1.0	0.9187154961768949	20	O00459,P06756	2
Microrna mirna biogenesis	0.2484944896222307	0.160195095723926	0.872727392550469	1.0	0.9234061325402022	13	Q9HAV4,P62826	2
Signaling by nuclear receptors	0.1687925481351378	0.1567942120144323	0.8754070345740192	1.0	0.9236719242616184	60	P04792,P27361,Q02790,P28482,P07900,P53041,Q13451,P08238,Q9HBH5,O00459,P35269	11
Activation of gene expression by srebf srebp	0.2262043722305159	0.1561098892334417	0.875946403453634	1.0	0.9236719242616184	19	P49327,Q13085,Q9UBM7,P48449,P14324,Q13907,Q15126,O00763	8
Foxo mediated transcription	0.2695859398272382	0.155714144296677	0.876258347635384	1.0	0.9236719242616184	9	Q13547,Q92769,P31946,P27348,P61981,P04179,P25208,P63104	8
Rac3 gtpase cycle	0.1895704155088413	0.1542114692253619	0.8774429992324464	1.0	0.9236719242616184	38	Q14739	1
Leishmania infection	0.1824808220019113	0.1541287205969658	0.8775082430881849	1.0	0.9236719242616184	44	O43865,Q9Y6W5,P27361,P62993,O15143,Q9UQB8,P28482,Q9UBI6,Q9Y2Z0,Q9Y2A7,Q96F07,P46108,P35579,P17612,P08238,Q96JJ3,O15145	17
Rhoa gtpase cycle	0.1744592124104995	0.1535121289079403	0.8779944261906556	1.0	0.9236719242616184	52	O00459,Q14739	2
Hiv transcription initiation	0.2341943000045207	0.1531938135214062	0.8782454361831782	1.0	0.9236719242616184	16	P18074,Q12962,P32780	3
Unfolded protein response upr	0.183143796065041	0.1489588209669652	0.8815861264765568	1.0	0.9257133556949176	42	P05198,P08243,Q14203,P51858,O94979,Q9Y2L1	6
Rna polymerase iii transcription	0.2440528150872317	0.1464607366393492	0.8835576832535865	1.0	0.9263556316909256	13	Q9H1D9,P05455	2
Early phase of hiv life cycle	0.2745271395101465	0.1457756529697669	0.8840984966743759	1.0	0.9263556316909256	8	P13010,P18858,P39748	3
Platelet homeostasis	0.2592662059971493	0.1417100386360392	0.887309045284751	1.0	0.927641274615876	10	P30153,Q06124,Q14738	3
Ephrin signaling	0.2938819769510016	0.1356949239616048	0.8920624606960443	1.0	0.930341584107627	5	Q16512,Q13177,P63000	3
Transmission across chemical synapses	0.1779605662079905	0.1286526159678534	0.8976325306937123	1.0	0.9349505869066654	42	P27361,Q12959,P54646,P28482,P05091,P04350,Q9BUF5,Q13885	8
Laminin interactions	0.2892268823475685	0.1258497443109997	0.8998508645019268	1.0	0.9358715810942944	5	P06756	1
Signaling by rho gtpases miro gtpases and rhobtb3	0.1495753097489741	0.1229403425593413	0.9021543391813872	1.0	0.9375722502751752	259	Q14739,P31948,P35579,Q16543,Q13409,Q96C19,P50748,P63167,P84095,P62258,P55072,Q93008,O00459,P27361,P40227,Q12792,Q13177,Q08378,Q86VI3,Q9P258,Q15058,Q9BUF5,P30153,Q8NBT2,Q15691,Q99832,Q9NP61,Q14738,P35080,O14974,Q9Y6G9,P30154,Q13885,Q13098,P60660,O60664,Q9BT78,P78371,O14964,O60610,Q02952,P04350,Q9BZH6,P52565,P63104,P35240,Q16513,Q13190,Q9H0H5,Q9Y6W5,Q14204,P27348,P12277,Q8IYB3,Q68EM7,Q5T8D3,Q13526,Q9UQB8,P28482,P61981,Q99707,P08238,P62993,O15143,P11274,Q9P2R3,O15498,O60566,Q5VTR2,P61201,Q96JJ3,Q16512,P07737,Q8NFH4,O43237,P07900,P23528,Q04917,O75886,P43034,P46940,Q9H2G2,P41240,P33176,Q96N67,Q96F07,Q9Y266,Q15334	88
Meiotic recombination	0.2507559691519774	0.119954514391691	0.9045191799559013	1.0	0.9386393561228766	10	P15927,P54132,P11802,P27694	4
Regulation of insulin secretion	0.228737042840086	0.1156156908107208	0.9079571268349604	1.0	0.940815250331942	14	P11166	1
Defects in cobalamin b12 metabolism	0.2575847709696514	0.1128428045091289	0.9101551819582292	1.0	0.941146911709258	4	Q9NPF0,Q99707,Q96EY8	3
Signaling by fgfr	0.1934743952118894	0.1039909600950923	0.917176522473676	1.0	0.9446489412413828	24	P27361,P35269,P28482,Q06124	4
Signaling by fgfr2	0.1934743952118894	0.1039909600950923	0.917176522473676	1.0	0.9446489412413828	24	P27361,P35269,P28482,Q06124	4
Diseases of mitotic cell cycle	0.2235050011010509	0.1020212807249129	0.9187397836396702	1.0	0.945008736397696	14	Q16763,P06400	2
G protein mediated events	0.227832336668291	0.0902346896458262	0.928100718406071	1.0	0.951845985324355	12	O43865	1
Influenza infection	0.1415184771819998	0.0879807216903985	0.9298919985787628	1.0	0.9523481779903428	128	P18621,P62910,P42766,P25398,P62249,P05388,P08865,P09874,P62266,P62861,P62081,P62753,P62854,P35268,P62899,P39019,O00410,P62750,P62701,P15880,P62851,P19525,P60866,P30050,P46781,P46783,Q8NFH4,P62273,P46777,P07900,P63173,P46782,P23396,P62277,P62244,P62826,P61247,P62841,P62857,P27635,P62913,P62847,P62888,P62829,P08708,P61513,P46778,P52294,P62906,P62269,P35269,P32969	52
Rab gefs exchange gtp for gdp on rabs	0.1811521494973374	0.0853949056866964	0.9319474430437288	1.0	0.9536996809557634	28	P61020,P20340,Q92930,Q7Z392,P20339,P51151,O43617,P51148,P62258,P62820,P31150,P50395,Q14C86,Q9NP72,Q14964,Q9H2M9,Q9Y296	17
Rho gtpase cycle	0.1231062480927155	0.0725886632748001	0.9421334483169028	1.0	0.9590699367266552	166	Q14739,P31948,Q16513,Q13190,Q9P2R3,Q99832,Q9H0H5,Q9NP61,Q16543,O15498,Q9Y6W5,Q96C19,P63167,P84095,Q5VTR2,P55072,P61201,P12277,Q93008,Q96JJ3,Q16512,O00459,Q13098,Q8IYB3,P40227,Q68EM7,Q5T8D3,Q9UQB8,P07900,Q12792,Q13177,Q99707,Q9BT78,Q08378,Q86VI3,P08238,O75886,P62993,P78371,P46940,Q9H2G2,P41240,Q15058,O14964,O60610,Q02952,Q96N67,Q96F07,Q9BZH6,Q9Y266,P11274,P52565	52
Ire1alpha activates chaperones	0.1810271875519511	0.0725559352034124	0.9421594928644704	1.0	0.9590699367266552	25	Q06210,Q14203,P51858,O94979,Q9NP61	5
N glycan trimming in the er and calnexin calreticulin cycle	0.198819695060479	0.0699280377874478	0.9442509368207423	1.0	0.9590699367266552	18	P62191,Q04323,P54727	3
Neuronal system	0.1435695070718633	0.0689276723269702	0.9450471915649248	1.0	0.9590699367266552	53	P27361,Q12959,P54646,P28482,P05091,P04350,Q9BUF5,Q13885,Q9UJU6	9
Cell cell communication	0.1726032631746993	0.0680758093953304	0.9457252869802047	1.0	0.9590699367266552	30	P62993,Q9Y5K6,Q96J84,P46940,Q06124,Q8NI35,O00459,Q15404	8
Transcriptional regulation of granulopoiesis	0.239654659124737	0.0630334885827539	0.9497398373009528	1.0	0.9613888829244132	7	P35659,P11802,Q03164,P62805,P24941,P40763	6
Sars cov 2 infection	0.1418012025587101	0.0142093949264664	0.9886629246767358	1.0	0.9914896950117658	26	Q96SB4,Q9Y3E7,P49841,Q8WUX9,Q9H444,Q99873,P55072,P49840,P06400	9
Abortive elongation of hiv 1 transcript in the absence of tat	0.1607014910690378	0.01274714003718	0.9898295292032744	1.0	0.9919505924801386	16	Q8IXH7,Q9H3P2	2