Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Processing of capped intron containing pre mrna 0.4602050793377567 5.365885116165534 8.055320427908775e-08 0.0001130903081733 0.0001130966988092 196 Q8WUM0,Q15459,Q9Y2W2,P08621,Q9UBU9,Q96QD9,Q9C0J8,Q9BTX1,O94992,P09651,P52597,Q14103,P62304,A8CG34,P55795,O43290,O94913,P12270,Q8TEM1,P49790,P61978,Q99567,Q8NFH5,Q9BUJ2,Q15427,P55769,O60508,Q8WWY3,Q7L014,Q86XP3,Q9BY77,Q96DI7,Q9UQ35,O94906,P09234,O75494,P82979,Q86W42,Q7RTV0,Q15717,Q9P013,Q9ULR0,Q9UKX7,Q9UNP9,Q13247,O75152,O15042,Q9Y3Y2,P52948,Q8IX12,O43390,Q9HCS7,P51991,P62995,P38159,Q13435,P24928,P52434,Q9BUQ8,Q8NFH4,Q8NI27,Q96LT9,Q00839,Q86V81,Q07955,O43172,Q99459,O15504,Q6P2Q9,P07910,Q6UN15,Q8IYB3,Q13151,O43395,P14866,P22626,O75934,P52272,P84103,P35658,Q86U42,Q8IWX8,O60306,O95400,P41223,Q13242,P30876,Q01081,P49792,Q8NFH3,P26599,P31943,P67809,Q9BZI7,Q9P2I0,Q53GS9,O75400,Q08211,P17844,P62310,O43660,Q08170 102 Rrna processing 0.4124855915142225 4.337326780833048 1.4422611692932463e-05 0.0200458487419592 0.0010154204529202 164 Q9GZL7,Q68CQ4,Q9NX24,P84098,Q99848,Q5RKV6,O15091,Q9H4L4,Q9NQT5,Q9Y4W2,Q9HC36,P61353,P61927,P62910,Q8IY81,P62266,O15213,Q96G21,Q9BVP2,Q9Y3A2,P47914,Q9NV06,Q9NR30,P46087,Q8NI36,O60832,Q9NPE3,Q14692,Q01780,P40429,P46782,P61313,P62750,P55769,Q9NW13,Q2NL82,O43818,P62917,Q9NY93,Q9H0S4,P62424,Q5SY16,P36578,P62753,P78316,Q12788,Q9H6R4,Q96EU6,P22087,P26373,P62913,P50914,P46779,Q14690,P56182,Q9NQZ2,O00567,P83731,Q8IZL8,Q14137,Q15061,O00566,Q9Y2R4,Q9BVJ6,Q969X6,Q9BVI4,Q07020,Q9H0D6,Q9Y3U8,Q15269,Q9Y5J1,Q13601,Q9Y3B2,Q9H0A0,Q8IY37,O00541,P19338,Q7L0Y3,Q9Y2X3,Q8TED0,O75691,Q9BV38,Q02878,Q9Y2P8,Q13868,P61513,P46777 87 Mrna splicing 0.4313698914496257 4.335089261431236 1.4570098799682183e-05 0.0202487516407756 0.0010154204529202 153 Q15459,Q9Y2W2,P08621,Q9C0J8,O94992,P09651,P52597,Q14103,P62304,P55795,O43290,O94913,P61978,Q9BUJ2,Q15427,Q8WWY3,O60508,P55769,Q7L014,Q86XP3,Q96DI7,Q9UQ35,O94906,P09234,O75494,Q7RTV0,Q15717,Q9P013,Q9ULR0,Q9UNP9,Q13247,O15042,Q8IX12,O43390,Q9HCS7,P51991,P62995,P38159,Q13435,P24928,P52434,Q9BUQ8,Q96LT9,Q00839,Q86V81,Q07955,O43172,Q99459,Q6P2Q9,P07910,Q6UN15,Q8IYB3,Q13151,O43395,P14866,P22626,O75934,P52272,P84103,Q86U42,Q8IWX8,O60306,O95400,P41223,Q13242,P30876,Q01081,P26599,P31943,P67809,Q9BZI7,Q9P2I0,Q53GS9,O75400,Q08211,P17844,P62310,O43660,Q08170 79 Sumoylation 0.5219866071115473 4.20331595798665 2.630330275010806e-05 0.0362567160163275 0.0010210537091873 80 Q12888,Q02880,Q53HL2,Q01831,Q9NQS7,Q9BTX1,P35658,O60216,Q96ST3,Q8NFH4,Q9UQE7,A8CG34,Q15424,Q14676,Q15022,P45973,Q9Y2X3,P12270,P62805,Q9UKX7,Q8NFH3,Q8TEM1,Q92841,O14965,Q14683,P11388,Q9HC52,P52948,P49790,P61978,Q8IXK0,Q9UER7,Q99567,O15504,P07910,Q8NFH5,P17844,Q96SB8,Q8WVM7 39 Transport of mature transcript to cytoplasm 0.520725750814531 3.5411252316513924 0.000398424423248 0.4285048925905545 0.0062943789754762 66 Q8WUM0,Q96QD9,P84103,Q9C0J8,Q9BTX1,O60508,P35658,Q9BY77,Q8NFH4,Q8NI27,A8CG34,P82979,Q13242,Q86W42,Q01081,P49792,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q13247,Q86V81,Q9BZI7,O75152,Q9P2I0,Q9Y3Y2,P52948,Q07955,P49790,O15504,Q99567,Q8NFH5,Q8IYB3,Q6UN15,Q08170 35 Metabolism of rna 0.2996215670693725 3.3874887041901216 0.0007053562166132 0.6286720173615341 0.0081173780993855 470 Q9GZL7,Q15459,P08621,P84098,Q96QD9,Q99848,Q9C0J8,Q9BTX1,Q9H4L4,Q9NQT5,Q9Y4W2,P09651,Q14103,Q9HC36,P52597,P61927,P62304,Q96F86,A8CG34,Q8IY81,P62266,P55795,O15213,O43290,O94913,P12270,Q96G21,Q8TEM1,Q9BVP2,Q9Y3A2,P47914,Q9NV06,Q9NR30,P49790,P61978,P46087,Q99567,Q8NFH5,Q8NI36,O60832,Q9BUJ2,Q9NPE3,Q14692,Q15427,Q86TB9,Q01780,P40429,P46782,P61313,P62750,Q8ND04,P55265,P55769,O60508,Q8WWY3,Q7L014,Q86XP3,Q96DI7,Q9BY77,Q9UQ35,Q9NW13,Q2NL82,O00267,O43818,P62917,Q9NY93,O94906,P09234,O75494,P82979,Q86W42,Q7RTV0,Q15717,Q9P013,Q9ULR0,Q9H0S4,P62424,Q5SY16,Q9UKX7,Q9UNP9,Q13247,O75152,P36578,O15042,Q9Y3Y2,P52948,P62753,P78316,Q9H6R4,Q12788,Q8IX12,O43390,Q96EU6,Q8IZD4,Q9HCS7,P51991,P22087,P26373,P62913,P46779,P50914,Q14690,P62995,P56182,P38159,Q9NQZ2,Q13435,O00567,P24928,P52434,P83731,Q9BUQ8,Q8IZL8,Q14137,Q8NI27,Q8NFH4,Q9HBH5,Q96LT9,Q15061,O00566,P17252,Q00839,Q9Y2R4,Q86V81,Q9BVJ6,Q969X6,Q969Y2,Q9BVC5,Q9BVI4,Q07955,O43172,Q99459,Q07020,O15504,P07910,Q6P2Q9,Q6UN15,Q8IYB3,Q52LJ0,Q13151,Q9H0D6,Q9Y3U8,Q15269,Q9Y5J1,O43395,P14866,P22626,O75934,Q13601,P52272,P84103,P35658,Q969T7,Q86U42,Q9Y3B2,Q9H0A0,Q5VV42,Q8IWX8,Q8IY37,O00541,O60306,O75648,O95400,P41223,Q13242,P19338,P30876,Q01081,Q7L0Y3,P49792,Q9Y2X3,Q8TED0,Q8NFH3,O75691,P26599,P31943,Q9BV38,P67809,Q9BZI7,Q9P2I0,Q02878,Q9Y2P8,Q53GS9,P61513,Q08211,P17844,O43660 187 Rrna modification in the nucleus and cytosol 0.5347904674533942 3.3449269847234784 0.000823042345041 0.6852659389621905 0.0088888573264433 56 P22087,Q9NPE3,Q14692,Q15269,Q9Y5J1,Q68CQ4,Q14690,Q13601,Q9NQZ2,P55769,O00567,Q9H0A0,O43818,Q8IY37,Q15061,O15213,O00566,Q9H0S4,Q9Y2X3,Q8TED0,Q96G21,Q9Y2R4,O75691,Q969X6,Q9BVJ6,Q9Y3A2,Q9NV06,Q9BVI4,Q9Y2P8,P62753,P78316,Q12788,Q9H6R4,P46087,Q96EU6,Q8NI36,O60832 37 Sumoylation of rna binding proteins 0.5927424726517181 3.325617198149347 0.000882230017744 0.7103835026216396 0.0092436637680044 34 P52948,P35658,Q9HC52,P49790,P61978,Q8IXK0,Q9Y2X3,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,P07910,Q8NFH5,A8CG34,Q9BTX1 17 Sumoylation of dna damage response and repair proteins 0.5514257643760325 3.3002701352370356 0.0009659180463319 0.7425177062769103 0.0100455476818522 46 Q01831,Q9BTX1,P35658,O60216,Q9UQE7,A8CG34,Q14676,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q14683,P52948,Q9HC52,P49790,Q8IXK0,O15504,Q99567,Q8NFH5,Q96SB8,Q8WVM7 21 Sumoylation of chromatin organization proteins 0.5740041860521489 3.2697676955283903 0.0010763583890338 0.7795360440504888 0.0107177814056988 37 Q8WUM0,Q9BTX1,P35658,Q8NFH4,Q13547,A8CG34,Q15022,P49792,P45973,P12270,P62805,Q9UKX7,Q8NFH3,Q8TEM1,P52948,Q9HC52,P49790,Q8IXK0,P57740,O15504,Q99567,Q8NFH5,Q969R5,Q06587 24 Nuclear envelope breakdown 0.5440965258628842 3.165471408727138 0.0015483187757852 0.8864513839621682 0.0143962884847843 42 P20700,P50402,P02545,Q8NC56,Q9BTX1,P42166,P35658,P42167,Q8NFH4,A8CG34,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q9Y2U8,P52948,P49790,O15504,Q99567,Q8NFH5 20 Slc transporter disorders 0.558896391791449 3.0922312252964113 0.001986580417312 0.9386974001330002 0.0176240803048418 35 P08195,P35658,P52948,Q6P1M0,P49790,P11166,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 15 Sumoylation of dna replication proteins 0.5523944543374871 3.06317158856562 0.0021900444369229 0.9539576803152606 0.018863941039508 36 P11388,P52948,P35658,P49790,Q53HL2,Q02880,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q8NFH4,O15504,Q99567,Q8NFH5,O14965,A8CG34,Q9NQS7,Q9BTX1 18 Epigenetic regulation of gene expression 0.525233992760774 3.050951193401075 0.0022811765250518 0.9594990743735488 0.0195290965925173 45 Q9GZS1,O94776,O15160,O95983,P35659,Q13185,O60264,O00159,Q9UIG0,Q8WXI9,P52434,O95602,Q96ST3,O15446,Q9NY93,Q13330,Q9BQG0,Q9H0E3,Q9H9Y6,Q13547,Q15022,Q96T88,P62805,Q9UIF9,O75533,P16104,Q9NR30,Q9UHR5,Q14839,O75530,O43159,Q86YP4 32 Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0.7165256367086846 2.9413167756952143 0.00326820124274 0.98990857354822 0.0262203116846118 16 Q9HC52,Q96GM5,Q8IXK0,P51532,Q8TAQ2,O14497,Q86U86,Q92925,Q68CP9 9 Positive epigenetic regulation of rrna expression 0.561609614972053 2.851027974903527 0.0043578135273836 0.9978272038837714 0.0334337168986153 29 Q9GZS1,O94776,O15160,O95983,P35659,Q13185,O60264,O00159,Q9UIG0,Q8WXI9,P52434,O95602,O15446,Q9NY93,Q13330,Q13547,Q9BQG0,Q9H9Y6,P62805,O75533,P16104,Q9NR30,Q14839,Q86YP4 24 Transport of mature mrnas derived from intronless transcripts 0.5143227454702847 2.787597250965303 0.005310051358901 0.999433014316913 0.0392384847784057 38 Q8WUM0,Q9C0J8,Q9BTX1,P35658,Q8NFH4,A8CG34,P49792,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q86V81,Q9P2I0,P52948,P49790,O15504,Q99567,Q8NFH5,Q6UN15 19 Meiotic synapsis 0.6750101227523004 2.7805556361020987 0.0054265960227504 0.9995190216820956 0.0398897424918407 17 P16104,O60216,Q15554,P20700,Q9UH99,P62805,Q9BTC0,P02545,Q9UQE7,Q8WXH0,Q14683,Q8WVM7 12 Sumoylation of sumoylation proteins 0.54645764438623 2.6592635545239003 0.0078311676281515 0.9999839248688066 0.0531157456518102 28 P52948,P35658,P49790,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 12 Sumoylation of ubiquitinylation proteins 0.54645764438623 2.6592635545239003 0.0078311676281515 0.9999839248688066 0.0531157456518102 28 P52948,P35658,P49790,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 12 Regulation of glucokinase by glucokinase regulatory protein 0.54645764438623 2.6592635545239003 0.0078311676281515 0.9999839248688066 0.0531157456518102 28 P52948,P35658,P49790,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 12 Chromatin modifying enzymes 0.3968046496366827 2.6093764576779908 0.0090707392478157 0.9999972210265238 0.0600722542638364 77 Q6VMQ6,Q03164,Q9BYW2,O94776,O95696,Q8NB78,Q9UBL3,O96028,Q92925,Q9Y4A5,Q9BZ95,P51532,O14497,O95619,P55201,Q9H0E3,Q8IYH5,Q92922,Q15022,O60341,Q9NPF5,P62805,Q8TAQ2,Q86U86,P16104,Q14839,Q96GM5,Q86YP4,Q8NHM5,Q96L91,Q68CP9 31 Dna damage telomere stress induced senescence 0.6298318813889255 2.501344136125878 0.0123722889042976 0.9999999743582992 0.0765228793904577 17 P16104,P07305,P10412,P62805,Q96L91,P16403,P16402 7 Cholesterol biosynthesis 0.6284238538416471 2.4924987699096306 0.0126847769924101 0.9999999835566644 0.0777704231325056 17 Q9BWD1,P37268,Q9UBM7,Q14739,P04035,Q16850 6 Rac3 gtpase cycle 0.4768426194324236 2.452409441346546 0.0141903092761217 0.9999999980703052 0.0840641106484174 38 P42166,Q9Y2U8,Q9H0H5,Q13112,P42167,Q14126,Q9UQB8,P11274,P49257,P05556,O00459,Q14739,P43121,Q15758,P50402,O96013,Q96RT1 17 Mitotic prophase 0.4298496123553088 2.4416349574009204 0.0146209223609878 0.9999999989550756 0.0857799839384905 63 P20700,P50402,P62820,P02545,Q8NC56,Q9BTX1,P42166,P35658,P42167,Q08379,A8CG34,P12270,P62805,Q9UKX7,Q8NFH3,Q8TEM1,Q14980,P16104,Q9Y2U8,P49790,O15504,Q99567,Q8NFH5 23 Transport of inorganic cations anions and amino acids oligopeptides 0.6803945152749407 2.390653794394425 0.0168184035949039 0.999999999954525 0.0937025343144648 12 P08195,Q9UBX3,Q9UPY5,P55011,Q96QD8,Q70HW3,Q15758,P04920 8 B wich complex positively regulates rrna expression 0.5847020425400309 2.380890347531085 0.0172708520633804 0.9999999999761708 0.0950912795960239 19 P16104,Q9NR30,Q9GZS1,O60264,O00159,Q9UIG0,P52434,P62805,O95602,O15446,Q9NY93,Q9BQG0,Q9H9Y6 13 Nuclear import of rev protein 0.4868473935835476 2.3756005192779117 0.0175204195742444 0.9999999999833185 0.0957146656896466 32 P52948,P35658,P49790,P49792,P12270,Q9UKX7,P06748,Q8NFH3,Q8NFH4,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 15 Transport of the slbp dependant mature mrna 0.4826866585472155 2.3397357699129997 0.0192973871411255 0.9999999999986864 0.1018553817524067 32 Q8WUM0,P52948,P35658,P49790,P49792,P57740,P12270,Q9UKX7,Q8NFH3,Q9UBU9,Q8NFH4,Q8TEM1,Q86V81,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 18 Depolymerisation of the nuclear lamina 0.7095190952270835 2.3368466246499064 0.0194471605164072 0.99999999999894 0.1022614732772876 10 P42166,Q9Y2U8,P42167,P20700,P50402,P02545 6 Reproduction 0.5286687154753023 2.3312464005016698 0.0197403707288899 0.9999999999993034 0.1026499277902274 25 P16104,Q8WVM7,O60216,Q15554,P20700,P62805,Q9BTC0,O94901,P02545,Q8WXH0,Q9UQE7,Q9UH99,Q14683,O60934 14 Meiosis 0.5286687154753023 2.3312464005016698 0.0197403707288899 0.9999999999993034 0.1026499277902274 25 P16104,Q8WVM7,O60216,Q15554,P20700,P62805,Q9BTC0,O94901,P02545,Q8WXH0,Q9UQE7,Q9UH99,Q14683,O60934 14 Nuclear pore complex npc disassembly 0.4846368644892121 2.32654283994437 0.0199896098385456 0.9999999999995126 0.1031816625489638 31 P52948,P35658,P49790,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 12 Phase i functionalization of compounds 0.623950691891352 2.313039679259774 0.0207204576542445 0.999999999999829 0.1042706901310372 15 Q5VT66,P07099,P30837,Q16850 4 Interactions of vpr with host cellular proteins 0.4678260713283839 2.3065991947835056 0.0210771744828197 0.9999999999998976 0.1053853563748158 35 Q8WUM0,Q8N1F7,Q9BW27,P05141,Q9BTX1,P35658,O75531,Q8NFH4,A8CG34,P52294,P49792,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q7Z3B4,P52948,P49790,P57740,O15504,Q99567,Q8NFH5,O75475 23 Rac1 gtpase cycle 0.4377870353775197 2.2919153882282575 0.0219105261156582 0.999999999999969 0.1083182347407893 52 Q14344,Q13112,Q9Y2I1,Q9UQB8,P05556,Q86UP2,Q96F07,P50402,P63000,P42166,P42167,O00459,Q96N67,P11274,Q14739,P43121,O96013,Q96RT1,O94887,Q9Y2U8,Q9H0H5,Q86VI3,Q15758 23 Formation of senescence associated heterochromatin foci sahf 0.7288152007405422 2.2728801018622105 0.0230334062092325 0.9999999999999938 0.1115134562681465 9 P07305,P10412,Q96L91,P16403,P16402 5 Rhod gtpase cycle 0.4785024942183029 2.2459501021251165 0.0247072041780447 0.9999999999999994 0.1148639558475986 30 P42166,Q9Y2U8,Q9H0H5,P42167,Q14739,Q9BX68,Q9UIW2,O00459,P43121,P50402 10 Pkmts methylate histone lysines 0.5890459231890017 2.24157966023159 0.024988551756798 0.9999999999999996 0.1156603721272021 17 Q15022,Q03164,Q9BYW2,Q9BZ95,P62805,O96028 6 Export of viral ribonucleoproteins from nucleus 0.4737140770745082 2.205078105973708 0.0274486141409846 1.0 0.1237301642406407 30 P52948,P35658,P49790,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 12 Negative epigenetic regulation of rrna expression 0.5045986758115718 2.2023674957718 0.0276393599677129 1.0 0.1237301642406407 26 P16104,Q9GZS1,Q9UHR5,O60264,P52434,P62805,O95602,Q96ST3,O15446,O43159,Q9UIF9,Q9H0E3 12 Transcriptional regulation by small rnas 0.4398769607672919 2.154836255834602 0.0311746500063332 1.0 0.1327476419026261 40 P16104,P52948,P35658,P49790,P24928,P52434,P12270,P62805,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 16 Rna polymerase ii transcription termination 0.4286659209561678 2.1518650490742735 0.0314079847136394 1.0 0.1327476419026261 48 Q96QD9,P84103,Q9C0J8,O60508,Q9BY77,Q86U42,P62304,Q8NI27,P82979,Q13242,Q86W42,Q01081,O94913,Q13247,Q86V81,Q9BZI7,O75152,Q9P2I0,Q9Y3Y2,Q07955,Q6UN15,Q8IYB3,Q08170 23 Cdc42 gtpase cycle 0.4506142637222749 2.1508882950769084 0.031485017630751 1.0 0.1327476419026261 35 Q14344,Q14160,P42166,Q9H0H5,P42167,Q96N67,Q9UQB8,Q14739,O00459,O96013,Q86VI3 11 Regulation of commissural axon pathfinding by slit and robo 0.807132243684993 2.145653949370422 0.0319005977816904 1.0 0.1329033806691197 2 Q9Y6N7 1 Other semaphorin interactions 0.806537890044577 2.1429882009216885 0.0321140458187789 1.0 0.1333968057087741 2 Q9UIW2 1 Slc mediated transmembrane transport 0.4818304386702048 2.140014171848271 0.0323536214622528 1.0 0.1337605813241762 28 P08195,Q9UBX3,Q9UPY5,Q6P1M0,Q6PCB8,Q96QD8,Q15758,Q70HW3,P55011,P11166,Q15043,P04920 12 Rac2 gtpase cycle 0.437165310365194 2.128963782059834 0.0332572570110394 1.0 0.136131745899415 40 P42166,Q13505,Q9Y2U8,Q13112,P42167,Q9H0H5,Q14126,Q9Y512,P11274,P49257,P05556,O00459,Q14739,P43121,Q6IAA8,P50402,O96013,Q96RT1 18 Egr2 and sox10 mediated initiation of schwann cell myelination 0.698283588705046 2.119037630577879 0.0340872868740065 1.0 0.1387204370176961 9 P46939,P04035,P51532,Q16850 4 Initiation of nuclear envelope ne reformation 0.5782614212978128 2.098304303106163 0.0358782726504482 1.0 0.1431112178996977 16 P42166,Q9Y2U8,P42167,P20700,Q14739,P50402,P02545 7 Hcmv early events 0.4249134021843866 2.0982877325184357 0.0358797355418045 1.0 0.1431112178996977 46 Q15022,P35658,P49790,Q9UER7,P05556,P12270,P62805,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,Q9BVA1,A8CG34,Q9BTX1 16 Rho gtpase cycle 0.2946488606916361 2.0892940209378534 0.0366812642851031 1.0 0.1432485511809212 166 Q14344,P14923,Q9BTT6,Q13112,Q15058,P20700,Q14126,Q9UQB8,Q9Y2I1,P05556,Q8WWQ0,Q86UP2,Q96F07,P62995,P38159,P50402,P63000,Q7Z6E9,Q96KM6,Q96HY6,Q14160,P42166,P42167,O75886,O75955,P27105,O00459,Q9UIW2,O60245,P84095,Q5T8D3,Q13505,Q96N67,P08670,Q14739,Q9BX68,P43121,P51572,Q9ULH0,O96013,Q96RT1,Q14254,O94887,Q07065,Q9Y2U8,Q9H0H5,Q5VTR2,Q96T58,Q08378,P07910,Q86VI3,Q15758 52 Sirt1 negatively regulates rrna expression 0.8959571938168834 2.0853972567241703 0.0370332556565253 1.0 0.1432485511809212 3 O43159,P62805 2 Rnd2 gtpase cycle 0.5196800824541389 2.018338874360488 0.0435559806939274 1.0 0.1624930314019847 20 Q9BTT6,Q14160,Q9Y2U8,Q15058,Q9Y2I1,O00459,P38159,Q07065 8 Mrna decay by 5 to 3 exoribonuclease 0.6490967266799093 2.017605265463416 0.043632388061644 1.0 0.1624930314019847 10 Q96F86,Q86TB9 2 Citric acid cycle tca cycle 0.5314495090300424 2.0157586444820006 0.0438252199531421 1.0 0.1627793883973851 19 P31040,O43837,P51553,P48735,P53597,P50213,P09622 7 Mitochondrial fatty acid beta oxidation of saturated fatty acids 0.7042469783449727 2.000359073479129 0.0454615043680011 1.0 0.166803744577154 8 P49748,P11310,P16219 3 Ionotropic activity of kainate receptors 0.7741456166419025 1.9966874237482053 0.0458591491501292 1.0 0.166803744577154 2 Q12959 1 Nrcam interactions 0.7741456166419025 1.9966874237482053 0.0458591491501292 1.0 0.166803744577154 2 Q12959 1 Mitotic telophase cytokinesis 0.587143610431738 1.9647571416863856 0.0494423528181549 1.0 0.1789099571048698 13 Q29RF7,Q9NTI5,O60216,Q02241,Q9UQE7,Q14683,Q8WVM7,Q6KC79 8 Viral messenger rna synthesis 0.424231448463542 1.9628142983175103 0.0496677557824223 1.0 0.1792635709987685 38 Q8WUM0,Q9BTX1,P13984,P35658,P24928,P52434,Q8NFH4,A8CG34,P30876,P49792,P12270,Q9UKX7,Q8NFH3,Q8TEM1,P52948,P49790,P57740,O15504,Q99567,Q8NFH5 20 Organic anion transporters 0.7649331352154538 1.9547239077712628 0.0506156666426262 1.0 0.1812867244036921 2 Q9UBX3 1 Cohesin loading onto chromatin 0.6324503124386077 1.927719699174396 0.0538900004788271 1.0 0.1882128374932173 10 Q9NTI5,O60216,Q9UQE7,Q14683,Q8WVM7,Q6KC79 6 Ercc6 csb and ehmt2 g9a positively regulate rrna expression 0.5973643454011092 1.918898956865115 0.0549971226836907 1.0 0.1916028790270515 12 P16104,Q14839,Q8WXI9,O94776,P62805,O95983,Q86YP4,Q13547,Q13185 9 Transcriptional activation of mitochondrial biogenesis 0.5936399577167554 1.897194149058343 0.0578023187870533 1.0 0.196499892438312 12 Q15648,P00367,P48735,O00411,Q96RR1 5 Cellular senescence 0.4096912530098859 1.8852008443030064 0.0594027268898955 1.0 0.2009672977190683 41 Q9HC52,Q15022,P07305,P10412,Q8IXK0,P62805,Q96L91,P16403,P16402 9 Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.8433412604042756 1.8741951945107704 0.0609035262434951 1.0 0.2050564768486024 3 Q9P2M7,Q9Y624 2 Gpvi mediated activation cascade 0.7431966348676575 1.8554701985788984 0.0635291110684193 1.0 0.2118643038956311 6 O00459 1 Basigin interactions 0.6706794309971024 1.833765213964948 0.0666888534714855 1.0 0.2182544295430436 8 Q13356,P05556,P08195,Q9UPY5 4 Rhoj gtpase cycle 0.482224910114436 1.8283445470391453 0.0674978581305447 1.0 0.2203883553843833 22 P14923,Q14160,P42166,P42167,Q13112,O00459,P27105,O96013,Q86VI3,Q15758 10 Collagen biosynthesis and modifying enzymes 0.5915576953849611 1.7894861268729343 0.073536559755317 1.0 0.2337399064200903 11 O60568,P13674,Q02809,O75718,Q32P28 5 Sumoylation of transcription cofactors 0.5752168361872683 1.7891864983210588 0.0735847853544728 1.0 0.2337399064200903 12 Q15424,Q9HC52,Q9UER7,Q8IXK0,Q96ST3,Q92841,P17844 7 Ns1 mediated effects on host pathways 0.4108773916200675 1.783130741169218 0.0745650233362018 1.0 0.2347550535091932 35 P52948,P35658,P49790,Q86U42,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q8NFH4,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 14 Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 0.806049902981429 1.7796380316444378 0.0751352179145417 1.0 0.2359951811007081 4 P16104,P62805 2 Establishment of sister chromatid cohesion 0.6584192420587776 1.7722783575930663 0.076348361990465 1.0 0.2387374170035921 8 Q9NTI5,O60216,Q9UQE7,Q14683,Q8WVM7 5 Mitochondrial translation 0.3800647416733749 1.762287544656549 0.078020727217086 1.0 0.2415091704064388 58 Q9NVS2,P49411,O75616,Q8TAE8,O60783,Q9Y2R9,P82930,Q9BYC9,P82933,Q9BYD2,Q5T653 11 Adrenaline noradrenaline inhibits insulin secretion 0.8155333456358678 1.76103865156716 0.0782318612709112 1.0 0.2415091704064388 3 P63096 1 Amino acid transport across the plasma membrane 0.7211485938167103 1.755074920728607 0.0792464934674574 1.0 0.2424010388416346 6 P08195,Q9UPY5,Q96QD8 3 Constitutive signaling by aberrant pi3k in cancer 0.7206594797893108 1.7528383447056166 0.0796297591970853 1.0 0.2430438737232779 6 O00459,P84095,P63000 3 Oxidative stress induced senescence 0.5340335629545566 1.7497383273487097 0.0801634768965771 1.0 0.2439524602455976 15 Q8IXK0,Q9HC52,Q15022,P62805 4 Protein protein interactions at synapses 0.5339332059831825 1.7490929431171691 0.080274954867141 1.0 0.2439524602455976 15 Q14168,O75955,Q9HCM4,O43491,Q12959,P10586,Q14254,Q15334,P11171 9 Hdacs deacetylate histones 0.5415164837076534 1.7397688353074223 0.0818996168250218 1.0 0.2462249722105583 14 Q14839,O60341,Q8WXI9,O94776,P62805,O95983,Q86YP4,Q13330,Q13547 9 Ptk6 regulates proteins involved in rna processing 0.8064803804993992 1.7239934569062638 0.0847090243693939 1.0 0.250382042557114 3 Q07666,O75525 2 Gaba receptor activation 0.7906862789957334 1.715962341721825 0.0861689351413352 1.0 0.2530987132603237 4 Q9UBI6,P63096 2 Adp signalling through p2y purinoceptor 12 0.7906862789957334 1.715962341721825 0.0861689351413352 1.0 0.2530987132603237 4 Q9UBI6,P63096 2 Gaba b receptor activation 0.7906862789957334 1.715962341721825 0.0861689351413352 1.0 0.2530987132603237 4 Q9UBI6,P63096 2 Collagen formation 0.5366993228350794 1.7094591144775384 0.0873659389255769 1.0 0.2555453713573126 14 O60568,P13674,Q02809,P23229,O75718,Q32P28 6 G alpha z signalling events 0.7479922837309838 1.708035452229259 0.0876297644649377 1.0 0.2557841773571156 5 Q9UBI6,P08754,P63096 3 Mitochondrial biogenesis 0.4079787966610032 1.7005533198763076 0.0890268960096991 1.0 0.2583247977754427 33 Q16891,P00846,Q13505,Q15648,Q9NX63,Q9Y512,Q9NVH1,P00367,P48735,O00411,P51610,Q96RR1 12 Peroxisomal lipid metabolism 0.5759312566299555 1.700323767201992 0.0890700422616235 1.0 0.2583247977754427 11 Q5T8D3,O15254,Q9BY49,Q9UJ83 4 Sumoylation of dna methylation proteins 0.7841126197619865 1.6886282438889373 0.0912906945832545 1.0 0.2583247977754427 4 Q9HC52 1 Mrna splicing minor pathway 0.4037496795501891 1.688002454861048 0.0914107577046634 1.0 0.2583247977754427 34 Q86XP3,Q96DI7,Q15427,Q07955,P24928,P52434,Q9BUQ8,P62304,Q13247,Q96LT9,O94906,P67809,P55769,Q13435 14 Apoptosis induced dna fragmentation 0.614234663843255 1.682691490820994 0.0924348298427051 1.0 0.2583247977754427 9 P16402,P07305,P16403 3 Adenylate cyclase inhibitory pathway 0.789214377337597 1.65308326230944 0.0983139192714896 1.0 0.2663670110278645 3 P63096 1 Regulation of pten gene transcription 0.4478105848398286 1.6494856112315592 0.0990481885796255 1.0 0.2672647402400652 24 Q8N122,Q9HC52,Q15022,Q6IAA8,Q14839,O60341,Q8IXK0,Q8WXI9,O94776,O75530,O95983,Q86YP4,Q13330,Q15382,Q13547,Q06587 16 G alpha s signalling events 0.7335096913899554 1.6446037856845652 0.1000515456682535 1.0 0.2680992769548241 5 Q9UBI6,P63096 2 Adp signalling through p2y purinoceptor 1 0.6977711738484408 1.6445635728455643 0.1000598441056466 1.0 0.2680992769548241 2 Q9UBI6 1 G protein activation 0.6977711738484408 1.6445635728455643 0.1000598441056466 1.0 0.2680992769548241 2 Q9UBI6 1 Apoptotic execution phase 0.4219644547347071 1.6357036837190095 0.1019016181585099 1.0 0.2719959541721444 28 P07305,Q07157,P10412,P20700,P08670,Q9UKV3,P51572,P16403,P02545,P16402 10 Interactions of rev with host cellular proteins 0.3949411637296895 1.6327773438593778 0.1025158337185332 1.0 0.2731161869844794 35 P52948,P35658,P49790,P49792,P12270,Q9UKX7,P06748,Q8NFH3,Q8NFH4,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 15 Activation of rac1 0.6941909409990106 1.631240416590677 0.1028396002715221 1.0 0.2734598461765476 6 O94813,O96013,Q9Y6N7 3 Mitochondrial fatty acid beta oxidation 0.4869626262748833 1.6276777046401758 0.1035932430033765 1.0 0.2749431250978085 18 Q16836,P49748,Q709F0,P11310,P16219 5 Hdms demethylate histones 0.6555254316848754 1.6264655134210744 0.1038506639484335 1.0 0.2751062871388693 7 Q8NB78,O60341,Q8NHM5,P62805 4 Rhog gtpase cycle 0.3822374246734119 1.612680333407525 0.1068139753923285 1.0 0.2813636424968653 41 P42166,Q9Y2U8,Q13112,P42167,Q14126,Q14739,P49257,P05556,P34897,P43121,Q86UP2,P50402,O96013,P84095,Q96RT1 15 Sema3a plexin repulsion signaling by inhibiting integrin adhesion 0.7227731046976036 1.597406705086443 0.1101750788173858 1.0 0.2885929303350928 5 O14786,Q9UIW2,P63000 3 Transcriptional regulation by the ap 2 tfap2 family of transcription factors 0.6861908499822433 1.594283666449835 0.1108725143452802 1.0 0.2898789760535818 6 P46087,Q6PL18 2 Activation of kainate receptors upon glutamate binding 0.7743757431628954 1.5918964182673578 0.1114079804891559 1.0 0.2907375550311801 3 Q9UBI6,Q12959 2 Heme degradation 0.7200082769498101 1.585230601117469 0.1129139501822567 1.0 0.2941209388791992 5 P09601,P53004 2 Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 0.5375957030372314 1.565571928424814 0.1174488660688415 1.0 0.3020113698913068 12 Q03164,P62805 2 Rna polymerase i transcription 0.4287268260407141 1.5414044171013763 0.1232183896748329 1.0 0.3134032954772924 25 P16104,Q9GZS1,Q9H9Y6,Q14839,O94776,O15160,Q8WXI9,P52434,O95983,O95602,O15446,P62805,Q86YP4,Q13330,Q13547,Q13185 16 Transcriptional regulation of granulopoiesis 0.6377161049243054 1.5394301670649349 0.1236993140484212 1.0 0.314038710842602 7 Q03164,P62805 2 Syndecan interactions 0.6321556996884634 1.512161629584069 0.1304927496527161 1.0 0.3258464476161163 7 P05556,O14936,P23229 3 Prc2 methylates histones and dna 0.668137139164946 1.5105796518081729 0.130895581521004 1.0 0.3258464476161163 6 Q15022,P62805 2 Attachment of gpi anchor to upar 0.7024708541407655 1.5078048121705707 0.1316044901867263 1.0 0.3270063989470607 5 O43292 1 Disinhibition of snare formation 0.7499999999999939 1.490967513035018 0.1359700244129162 1.0 0.3355042430153505 3 O00186,Q12846 2 Inactivation of cdc42 and rac1 0.7351458037622809 1.4835809183942663 0.1379201347004304 1.0 0.3385312397192383 4 O94813,Q9Y6N7 2 Regulation of tp53 activity through acetylation 0.499399519142177 1.4725376804358268 0.1408757395356685 1.0 0.345182440328235 14 Q14839,O95696,Q86YP4,P55201,Q9NPI1 5 Recognition and association of dna glycosylase with site containing an affected purine 0.6935157593885983 1.4681544261552977 0.1420622804199967 1.0 0.3474833479262637 5 P16104,P29372,P62805 3 Negative regulation of nmda receptor mediated neuronal transmission 0.691861570021163 1.4608227490653711 0.144064091052799 1.0 0.3493367596513469 5 Q14168 1 Unblocking of nmda receptors glutamate binding and activation 0.691861570021163 1.4608227490653711 0.144064091052799 1.0 0.3493367596513469 5 Q14168 1 Ras activation upon ca2 influx through nmda receptor 0.691861570021163 1.4608227490653711 0.144064091052799 1.0 0.3493367596513469 5 Q14168 1 Long term potentiation 0.691861570021163 1.4608227490653711 0.144064091052799 1.0 0.3493367596513469 5 Q14168 1 Met promotes cell motility 0.5963661507385667 1.456561729232668 0.1452373983434611 1.0 0.3503665073440197 8 P05556,Q96N67,P07942 3 Neurexins and neuroligins 0.5712067327177661 1.4530355634510863 0.1462138800864902 1.0 0.3515141911668362 9 Q14168,Q9HCM4,O43491,Q15334,P11171,O14936 6 Gene silencing by rna 0.3608112244428418 1.4505171127902696 0.1469143706162365 1.0 0.3525944894789677 49 P16104,P52948,P35658,P49790,P24928,Q9Y2W6,P52434,P12270,P62805,Q9UKX7,Q8NFH3,Q8TEM1,Q8NFH4,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 18 Inla mediated entry of listeria monocytogenes into host cells 0.6537890044576533 1.4383156411610756 0.1503445159127467 1.0 0.3583764012589074 2 P35222 1 Assembly and cell surface presentation of nmda receptors 0.5382468698426872 1.4053239550221308 0.1599249681670802 1.0 0.374718468789219 10 Q9BVA1,Q14168,Q15334,Q12959 4 Notch4 intracellular domain regulates transcription 0.6466567607726608 1.4047314814265162 0.160101140648774 1.0 0.374718468789219 2 Q04721 1 Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.6363271191298986 1.362278345173136 0.1731100589870697 1.0 0.3982973650275028 6 O60934,P51530,Q9UQ84 3 Resolution of d loop structures 0.6363271191298986 1.362278345173136 0.1731100589870697 1.0 0.3982973650275028 6 O60934,P51530,Q9UQ84 3 Post translational modification synthesis of gpi anchored proteins 0.5533239396481662 1.3567050413357111 0.1748749500006172 1.0 0.4005292492673191 9 O43292,Q9H490 2 Rho gtpases activate cit 0.5294522972636291 1.3556254840335018 0.1752183592589808 1.0 0.4005546864155174 10 Q7Z406,O14974,Q15058,P35580,P63000,Q15334 6 Rhobtb1 gtpase cycle 0.4274215429519817 1.3373883330316814 0.1810959107657039 1.0 0.4100946108307232 20 P08670,Q96T58,P62995,P38159,Q7Z6E9 5 Beta oxidation of butanoyl coa to acetyl coa 0.6993142598076851 1.33239638470179 0.1827299694900448 1.0 0.4124644327395867 4 P16219 1 Deposition of new cenpa containing nucleosomes at the centromere 0.5718938865009928 1.3304794277965533 0.1833603600596505 1.0 0.4132230265228721 8 P16104,O60264,Q92674,P62805,Q96T23 5 Signal amplification 0.5933205668041768 1.3207534208503098 0.1865835953574379 1.0 0.4187940401617052 7 Q14344,Q9UBI6,P08754,P63096 4 Regulation of lipid metabolism by pparalpha 0.423890551088767 1.3108212410031284 0.1899181645001317 1.0 0.4252712965840271 20 P37268,Q15648,P11310,P04035,O60244,P23786 6 Rhof gtpase cycle 0.4417102382812861 1.307747048936342 0.190959119506024 1.0 0.4263896651094095 18 P42166,O00459,P42167,P43121 4 Base excision repair ap site formation 0.6206759919623238 1.2890642834005832 0.1973757392196078 1.0 0.4323175317696246 6 P16104,P29372,P62805 3 Adherens junctions interactions 0.586607142857144 1.2875475035464832 0.1979035234378412 1.0 0.4327983596678023 7 P14923,P55196,Q92692,O60716,P35222,P19022 6 Formation of the beta catenin tcf transactivating complex 0.5039670440078555 1.2825744738634446 0.1996411978852177 1.0 0.4359195051801643 11 P16104,Q6P1J9,Q9Y4A5,P51532,P62805,Q9UBL3,P35222,Q13547 8 Wax and plasmalogen biosynthesis 0.6856152784379371 1.2744867915467857 0.2024909507893828 1.0 0.4375726973973747 4 Q6IAN0,Q8WVX9 2 Alpha oxidation of phytanate 0.6855613364055895 1.2742587439916837 0.2025717324409606 1.0 0.4375726973973747 4 Q9BY49 1 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.697527315505614 1.2726427101337567 0.2031448555412911 1.0 0.4375726973973747 3 Q8NB78 1 Acyl chain remodeling of cl 0.6172362555720665 1.266070377223077 0.2054878869970018 1.0 0.4397941971704124 2 P55084 1 Calnexin calreticulin cycle 0.5004884905296139 1.262183841964036 0.2068826415204876 1.0 0.4401604609891219 11 P30101,P27824,Q9UBV2,Q9NYU1,Q14697,Q13438,Q9GZP9 7 Rna polymerase i transcription initiation 0.4129946651248715 1.2605842801205085 0.2074586652509542 1.0 0.4401604609891219 21 Q9GZS1,Q14839,Q8WXI9,O94776,O15160,P52434,O95983,O95602,O15446,Q86YP4,Q13330,Q13547,Q9H9Y6 13 Interleukin 7 signaling 0.6944025735861761 1.2596286143516169 0.2078033681136348 1.0 0.4401604609891219 3 O00459 1 Maturation of sars cov 1 spike protein 0.6812070049150684 1.2558507818004947 0.2091700760273314 1.0 0.4416764134332446 4 Q13724,Q14697 2 Cell cell junction organization 0.5292399326307912 1.2264958771944388 0.2200121258419844 1.0 0.455857096714676 9 P14923,P55196,Q92692,O60716,Q9Y624,P35222,P19022 7 Signal transduction by l1 0.4805958208455127 1.2210952427473798 0.2220499607053236 1.0 0.455857096714676 12 O14786,P05556,P13591 3 Dna methylation 0.6722686638824273 1.2180727618322245 0.2231963236259024 1.0 0.455857096714676 4 P62805 1 Tp53 regulates transcription of genes involved in cytochrome c release 0.669500736794443 1.2063782786110235 0.2276716674356014 1.0 0.455857096714676 4 Q13625,Q9Y255 2 Inhibition of dna recombination at telomere 0.4576498623153804 1.2041195273742396 0.2285433834278984 1.0 0.455857096714676 14 P16104,Q15554,P24928,Q9UER7,P46100,P52434,P62805 7 Mecp2 regulates transcription of neuronal ligands 0.6789536266349484 1.1953244075867426 0.2319603071908385 1.0 0.4589376255907969 3 Q96ST3,P51608 2 Nuclear envelope ne reassembly 0.3361158560875282 1.1834509104465958 0.2366304907016192 1.0 0.4657970179405201 48 P42166,Q9Y2U8,P42167,P20700,Q14739,Q8WYP5,Q8NFH3,P50402,P02545,Q8NC56,Q9BVA1 11 Synaptic adhesion like molecules 0.597546739919458 1.1807951959936336 0.237684092968835 1.0 0.4660732772740844 6 Q14254,Q12959,P10586,O75955 4 Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0.5985141158989612 1.1779350226569378 0.2388225114252813 1.0 0.466351607845751 2 P52292 1 Camk iv mediated phosphorylation of creb 0.5985141158989612 1.1779350226569378 0.2388225114252813 1.0 0.466351607845751 2 P52292 1 Er quality control compartment erqc 0.5940544099998668 1.164456762252274 0.2442389558967372 1.0 0.4723298816515414 6 Q9UBV2,Q9GZP9,Q9NYU1 3 Free fatty acids regulate insulin secretion 0.6700356718192577 1.1582545176579706 0.2467601862126391 1.0 0.4742948756487338 3 O95573,P29992 2 Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.6230539297662215 1.154853889336083 0.2481502647014584 1.0 0.4742948756487338 5 O00459 1 Crmps in sema3a signaling 0.5914750152272836 1.1523931588011234 0.2491595509379425 1.0 0.4748202323767821 6 O14786,Q9UIW2 2 Snrnp assembly 0.3363225430807398 1.1499045212956611 0.2501831984895029 1.0 0.4759582800532005 41 P35658,P49790,P12270,P62304,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q8NFH5,Q99567,A8CG34,Q9BTX1 12 Trna modification in the mitochondrion 0.557604756091514 1.1440283959450672 0.2526118609145453 1.0 0.4787690087849799 7 Q9Y2Z2,O15091,Q7L0Y3,Q969Y2,O75648 5 Negative regulation of the pi3k akt network 0.4546242497235266 1.142736920102243 0.2531478359717898 1.0 0.4790021047229015 13 O00459 1 Beta oxidation of hexanoyl coa to butanoyl coa 0.6177979179583787 1.1315016705641168 0.2578440006931946 1.0 0.4839745681460497 5 P16219 1 Signaling by ptk6 0.4509990595714125 1.1199010463726593 0.2627559323520696 1.0 0.488935917140927 13 Q8IZL8,Q07666,P23246,O75525 4 Laminin interactions 0.6114838295297145 1.1034765098973651 0.2698202870341288 1.0 0.4947349507550312 5 P05556,P07942 2 Extracellular matrix organization 0.332672302716028 1.084247955641277 0.2782548740823118 1.0 0.5029614266297496 39 O60568,P78536,P17252,P05556,O15446,Q02809,P13674,Q9Y624,P23229,P07942,O75718,P13591,O14936,Q32P28 14 Rna polymerase i promoter escape 0.4323607977501884 1.0840371873725283 0.2783483108912503 1.0 0.5029614266297496 15 P16104,Q9GZS1,P52434,P62805,O15446,O95602,Q9H9Y6 7 Cell surface interactions at the vascular wall 0.3936062945192985 1.0828280625994442 0.2788847470613467 1.0 0.5032830139770318 20 Q13356,P08195,Q9UPY5,P78310,O00459,Q9Y624 6 Rnd1 gtpase cycle 0.4173211134056978 1.079391922993267 0.2804130500404893 1.0 0.50506048015182 17 Q9Y2U8,O00459,P38159,Q15058 4 Release of apoptotic factors from the mitochondria 0.6492854467411985 1.0722497376997433 0.2836078757822302 1.0 0.5072426211442691 3 Q07812 1 Rnd3 gtpase cycle 0.399074002096428 1.0612321422191855 0.2885844154936334 1.0 0.5109363421854495 19 Q9Y2U8,Q9Y2I1,O00459,P38159,Q07065 5 Met activates ptk2 signaling 0.6425002636979535 1.0442318684705565 0.2963781259758324 1.0 0.5222508268187991 3 P07942 1 Rmts methylate histone arginines 0.3818717610863745 1.022537697227892 0.3065264801470015 1.0 0.532818418768817 21 P16104,Q96GM5,P51532,P62805,Q8TAQ2,O14497,Q86U86,Q92925,Q68CP9 9 Beta oxidation of octanoyl coa to hexanoyl coa 0.591350690656203 1.0144077173865915 0.3103882433452245 1.0 0.5384239506657332 5 P11310 1 Downregulation of erbb4 signaling 0.5634472511144146 1.0139026593422684 0.3106292023071537 1.0 0.5384239506657332 2 P46934 1 Rhoc gtpase cycle 0.3302424867837353 0.9943553315711908 0.3200499065800857 1.0 0.5500000842575768 34 P14923,P42166,Q9H0H5,P42167,O75955,Q14739,P49257,P27105,P43121,Q86VI3,Q96RT1,Q14254,Q5T8D3 13 Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 0.6176033303597752 0.9882011338816608 0.3230541529747714 1.0 0.5538071193853225 4 P11310,P42126,P55084 3 Beta oxidation of decanoyl coa to octanoyl coa coa 0.555440788613188 0.9845329045219672 0.3248535610545127 1.0 0.5555352006340266 6 P11310 1 Hcmv late events 0.3197391605208366 0.9695813258538188 0.3322552248519419 1.0 0.5661241938011244 40 P35658,P49790,P61978,P62805,P12270,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1 13 Regulation of mecp2 expression and activity 0.4551626180893283 0.9349139431215308 0.3498326508511846 1.0 0.5875179925778268 10 Q14739,P51608,Q96ST3 3 Sensing of dna double strand breaks 0.6045197740112878 0.9337968375035762 0.3504087011565961 1.0 0.5877823374239678 4 O60934,Q92878,P52292 3 Integrin cell surface interactions 0.5440543463534746 0.9319254177753314 0.3513750707099334 1.0 0.5886999991369292 6 Q9Y624,P05556 2 Loss of function of mecp2 in rett syndrome 0.5714677474553458 0.927098994351022 0.3538751382467602 1.0 0.5900720832523175 5 Q96ST3,P51608,P17252 3 Neuronal system 0.3097921702630933 0.9214710998490928 0.3568045230165224 1.0 0.5942509493655961 53 P63000,O95782,O75955,P51649,P10586,P08754,P11171,Q14168,Q96QD8,O43491,P17252,Q12959,Q9BVA1,Q14254,P63096,Q9UBI6,Q9HCM4,Q15334,O14936 19 Rhobtb gtpase cycle 0.332788363473006 0.9053576538254428 0.3652759419839162 1.0 0.602437743317871 29 P08670,Q8WWQ0,Q96T58,P62995,P38159,Q7Z6E9 6 Gap junction trafficking and regulation 0.449861202677574 0.9051547585128688 0.3653834058210328 1.0 0.602437743317871 10 Q07157 1 Rhoa gtpase cycle 0.3086890773972582 0.904780133536902 0.3655818784236653 1.0 0.602437743317871 52 P14923,P42166,Q9H0H5,P42167,O75955,Q14739,P49257,O00459,P27105,O60245,Q86UP2,P43121,P51572,Q86VI3,Q96RT1,Q14254,Q5T8D3,Q96HY6 18 Pi3k akt signaling in cancer 0.4494099573745974 0.9026256936073628 0.3667245853336196 1.0 0.603439310321535 10 O00459 1 Notch hlh transcription pathway 0.5968339631063897 0.9020143081744556 0.3670492671044094 1.0 0.603439310321535 4 Q13547,Q04721 2 Cristae formation 0.3690951283665248 0.8996422450507523 0.3683106679731844 1.0 0.6040983385915315 20 Q16891,P00846,Q13505,Q6UXV4,Q9NX63,Q9Y512,Q9NVH1,Q5XKP0 8 Apoptotic cleavage of cellular proteins 0.3878012118840256 0.876452809648367 0.3807839199546063 1.0 0.6178494032872942 17 Q07157,P08670,P20700,Q9UKV3,P51572,P02545 6 Processing of dna double strand break ends 0.3503167793689166 0.8676597119472177 0.3855806472710308 1.0 0.6222831648202692 24 P16104,Q14676,P62805,Q9UQ84,O96028 5 Met activates rap1 and rac1 0.5577990325322456 0.867619229661746 0.3856028158074318 1.0 0.6222831648202692 5 Q96N67 1 Pre notch expression and processing 0.4210315758165383 0.8611678767735447 0.3891455895393068 1.0 0.6256864845879252 12 P16104,Q9UBV2,P62805 3 Diseases of dna repair 0.4612545979361122 0.8605348288781567 0.3894942931124263 1.0 0.6256864845879252 9 O60934,P51530,Q9UQ84 3 N glycan trimming in the er and calnexin calreticulin cycle 0.3781299487522968 0.857342767933818 0.3912554789941183 1.0 0.6270806992097512 18 Q9UBV2,Q9NYU1,Q14697,Q13438,Q9GZP9 5 Metabolism of steroids 0.3033062070523612 0.8468055655162651 0.397103505586331 1.0 0.635003783420511 43 Q9BWD1,P37268,Q9UBM7,Q14739,P04035,Q14534,Q16850 7 Regulation of tp53 activity 0.302557950082333 0.8335990106912148 0.4045069833055597 1.0 0.6410034866409697 50 Q13625,Q9ULW0,Q9NPI1,Q14839,Q9UER7,O94776,O95696,Q92804,Q9Y3T9,Q86YP4,P51530,Q9UQ84,P55201,O14965 14 Trna processing in the mitochondrion 0.579839429081184 0.8323072760901432 0.4052355246687817 1.0 0.6410034866409697 4 Q7L0Y3,O15091,Q99714 3 Dna double strand break response 0.3592657141934254 0.8270712784277776 0.4081966623450537 1.0 0.6429433038685388 20 P16104,Q14676,Q9UIG0,P62805,O96028 5 Muscle contraction 0.341169597245344 0.8265720779496006 0.4084796488965361 1.0 0.6429433038685388 25 P23634,P07355,P04083,P08670 4 Regulation of pten localization 0.5203566121842513 0.8165397364928131 0.4141915062405972 1.0 0.6512036671464708 2 P46934 1 Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0.5739584853930563 0.808397288039549 0.4188619126537212 1.0 0.653043186178692 4 Q96ST3 1 Trafficking of ampa receptors 0.4192895971948523 0.7893466454987954 0.4299094307566413 1.0 0.6662172635566495 11 Q15334,O95782,Q12959 3 Dna damage recognition in gg ner 0.3515387918535747 0.770567372961185 0.4409634065214438 1.0 0.6795351522788134 20 Q01831 1 Kinesins 0.3650743643986659 0.7668895425242556 0.4431471917600613 1.0 0.6814662182159104 18 Q9BVA1,Q14807,Q96Q89,Q86Y91 4 Nonhomologous end joining nhej 0.3767418405599816 0.7601936882567748 0.4471388172462616 1.0 0.6861015294139358 16 P16104,Q14676,Q12888,P62805,O96028 5 Leishmania infection 0.293308667792251 0.7436391407080272 0.4570948171785343 1.0 0.6983254878331471 44 Q9UQB8,Q9Y4I1,P09601,P78536 4 Sema4d in semaphorin signaling 0.4739594053398673 0.7369910419775905 0.4611277969755205 1.0 0.7037211162539465 7 P35580,P63000 2 Homology directed repair 0.2962882601005693 0.730394905033113 0.4651488317934587 1.0 0.7075503356858244 39 P16104,Q14676,P35251,Q12888,P62805,Q15054,Q9UQ84,O96028 8 Degradation of the extracellular matrix 0.3982726348558296 0.7268706252525795 0.4673052134308904 1.0 0.7084669244363362 12 O15446,P78536 2 Ra biosynthesis pathway 0.5534948099268121 0.7262327263168806 0.4676961126727641 1.0 0.7084669244363362 4 Q9HBH5 1 Neurotransmitter receptors and postsynaptic signal transmission 0.2999675575773605 0.7146311277526175 0.4748370051479429 1.0 0.7146647873147189 34 Q14168,Q9UBI6,P17252,Q12959,P08754,Q15334,P63000,Q9BVA1,O95782,P63096,O14936 11 Fcgamma receptor fcgr dependent phagocytosis 0.2962245691263567 0.7037499358638175 0.4815885164340852 1.0 0.720074842463744 36 Q9UQB8,Q9Y4I1,O00459 3 Postmitotic nuclear pore complex npc reformation 0.3322198566548784 0.6994590576126345 0.4842651911740296 1.0 0.722538074822888 23 P52948,Q8WYP5,Q8NFH3,Q8NFH5,Q9BTX1 5 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.492421991084697 0.6930483538192157 0.4882792070872395 1.0 0.724888728488528 2 P04637 1 Activation of gene expression by srebf srebp 0.3476366282324181 0.6926704189486468 0.4885164070381815 1.0 0.724888728488528 19 P37268,Q9UBM7,P04035,Q14534,Q16850 5 Hats acetylate histones 0.3160380634451946 0.689235402615185 0.4906751414049344 1.0 0.7259303461881221 27 Q8IYH5,Q9Y4A5,O95696,P62805,Q96L91,O95619,P55201,Q9H0E3 8 Anti inflammatory response favouring leishmania parasite infection 0.3710096118662774 0.6872447148943576 0.4919285309764309 1.0 0.727018586832536 15 Q9UBI6,P08754,P63096,P78536 4 Hcmv infection 0.2854609299888514 0.684195345142964 0.493851821229186 1.0 0.7290935404897761 57 Q15022,P35658,P49790,P61978,Q9UER7,P05556,P12270,P62805,Q9UKX7,Q8NFH3,Q8TEM1,O15504,Q99567,Q8NFH5,Q9BVA1,A8CG34,Q9BTX1 17 Nrif signals cell death from the nucleus 0.4876671619613686 0.6725146793779941 0.501256098133616 1.0 0.7376976538570198 2 P49768 1 Heme signaling 0.5105293213502683 0.6672517008026546 0.5046113720204466 1.0 0.7403075928074263 5 P09601,Q15648 2 Rhoq gtpase cycle 0.3340631483675335 0.6657413398928852 0.5055764449788582 1.0 0.7409491949377004 21 P14923,Q14160,Q13112,P27105,O96013,Q86VI3,Q15758 7 Rho gtpases activate ktn1 0.484577616293003 0.6643111251204934 0.5064912020713259 1.0 0.7415157953161017 6 P84095,P63000 2 Transmission across chemical synapses 0.2840008366955958 0.6449578362820134 0.5189545098296733 1.0 0.7534768684600427 42 Q14168,Q9UBI6,Q96QD8,P17252,P51649,Q12959,P08754,Q15334,P63000,Q9BVA1,O95782,P63096,O14936 13 Metabolism of porphyrins 0.3925464772925669 0.6393026520914723 0.5226260635125715 1.0 0.7549043139626033 11 P09601,P50336,P53004,P36551 4 Parasite infection 0.3088301120636491 0.631461893171133 0.52773855795584 1.0 0.7576124083537826 27 Q9UQB8,Q9Y4I1 2 Interleukin 4 and interleukin 13 signaling 0.3813951952429593 0.6297170556892853 0.5288797215586021 1.0 0.7578207430169165 12 Q07820,P09601,P08670 3 Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4160415985695955 0.6258033184443269 0.5314439549700782 1.0 0.7594258122055039 9 Q14168 1 Fcgr activation 0.4766716196136718 0.6256743424995417 0.5315285656092632 1.0 0.7594258122055039 2 P07948 1 Transcriptional regulation by mecp2 0.3699601449438957 0.6212000285022555 0.5344680206931869 1.0 0.7614339041699385 13 Q14739,P51608,Q8WYQ5,Q96ST3 4 Thromboxane signalling through tp receptor 0.5259825645822751 0.618931093887042 0.5359617535410839 1.0 0.7616298602952245 4 Q14344,Q9UBI6 2 Glutamate and glutamine metabolism 0.4480731649007694 0.6168803323845484 0.5373136602766464 1.0 0.7627789474503656 7 P32322,P00367,P54886 3 Interferon gamma signaling 0.3664886341132676 0.6008900969498431 0.5479131895477869 1.0 0.7720630848262791 13 P19474 1 Rho gtpases activate paks 0.3662164188875786 0.5993035051331569 0.5489705109163305 1.0 0.772299195717964 13 Q7Z406,O14974,P35580,P63000,P35240 5 Signaling by vegf 0.2919503466009409 0.5942211808552171 0.5523641879333585 1.0 0.7743760899803116 30 Q9UQB8,O00459 2 Adora2b mediated anti inflammatory cytokines production 0.4082258758230956 0.5866860900156841 0.5574145515615905 1.0 0.7795721039677522 9 Q9UBI6,P08754,P63096 3 Semaphorin interactions 0.3211516849124771 0.5738140107039171 0.5660936666817706 1.0 0.7884876071638948 21 P35580,Q9UIW2,P05556,O14786,P63000,Q14195,O94887 7 Rho gtpases activate iqgaps 0.3802504030757449 0.5723654850460024 0.5670743937368865 1.0 0.7890708115030611 11 Q9BVA1,Q86VI3 2 Mitochondrial calcium ion transport 0.3412720468677749 0.5687944271799535 0.5694956570126659 1.0 0.7908723070680346 17 Q92667,P35232,Q8WWC4,Q9UJZ1,Q96TA2,Q8NE86,Q9Y4W6,P45880,Q99623,Q9Y277 10 Non integrin membrane ecm interactions 0.3782593942059739 0.5616781855183911 0.574335299733467 1.0 0.7961263309902755 11 P05556,P23229,P07942,O14936 4 Chl1 interactions 0.515872337452266 0.5467232698811579 0.584568864880209 1.0 0.8038537573866928 3 O14786 1 Synthesis of very long chain fatty acyl coas 0.4305990305192148 0.5386673080139053 0.5901164353198027 1.0 0.8076187663884646 7 O60488,O95573,Q4G176,Q53GQ0 4 Rhob gtpase cycle 0.2967377433207306 0.5369047659504317 0.5913333987516678 1.0 0.8076187663884646 27 P14923,Q9H0H5,O75955,P27105,O00459,O60245,P43121,Q86VI3,Q96RT1,Q14254 10 Fgfr2 alternative splicing 0.3344276334984901 0.5258128790744002 0.5990182252366909 1.0 0.8165569235047008 17 P30876,P09651,P52597,P31943,P24928,P52434,P26599,P52272 8 Antigen activates b cell receptor bcr leading to generation of second messengers 0.5039646670345752 0.5043671465657408 0.6140034002923045 1.0 0.830056212675185 3 O43865 1 Cell junction organization 0.3193833322221543 0.5021434530581297 0.6155666160781523 1.0 0.8302166464685167 19 P14923,Q13418,Q92692,Q14315,P05556,Q9Y624,P21333,P35222,P19022,P23229 10 Cell cell communication 0.2804956352596532 0.5003805857848654 0.6168071208369501 1.0 0.8310913605135105 30 P14923,Q13418,Q92692,Q14315,Q01082,Q13813,P05556,O00459,Q9Y624,P21333,P35222,P19022,O14936,P23229 14 Regulation of insulin secretion 0.3438675272634211 0.4954581110602388 0.6202767837503833 1.0 0.8349651048758756 14 Q9UBI6,P11166,P17252,O95573,O60488,P29992,P63096 7 Incretin synthesis secretion and inactivation 0.4890116070949081 0.4825154748937829 0.6294398080266683 1.0 0.8392530773688911 4 P35222,P67812 2 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.4890116070949081 0.4825154748937829 0.6294398080266683 1.0 0.8392530773688911 4 P35222,P67812 2 Tp53 regulates transcription of cell death genes 0.4628904920797645 0.4788369451732122 0.6320546313808568 1.0 0.8411418980651403 5 Q13625,Q9Y255 2 Mitochondrial protein import 0.2713420354269398 0.4662369751562955 0.6410458856269274 1.0 0.8506884909453744 34 Q13505,Q9UJS0,Q9NX63,Q9Y512,O75431,P51553,O60830,O75746,O96008,Q99595,P10809,Q5JRX3,Q99798 13 Atf6 atf6 alpha activates chaperones 0.4922711058263848 0.4639320325396525 0.642696442049697 1.0 0.8512696270167686 3 P14625,P27797 2 Atf6 atf6 alpha activates chaperone genes 0.4922711058263848 0.4639320325396525 0.642696442049697 1.0 0.8512696270167686 3 P14625,P27797 2 Erythropoietin activates ras 0.488703923900106 0.4518431103370334 0.6513820103614678 1.0 0.8608453428419423 3 P46109,P07948 2 Processing of smdt1 0.3487332339791313 0.4507682061645851 0.6521566182918888 1.0 0.8608453428419423 12 Q8IYU8,P35232,O75439,Q10713,Q8WWC4,Q96TA2,Q9UJZ1,Q9H300,Q8NE86,Q9Y4W6,Q99623 11 Hdr through homologous recombination hrr 0.3001089626741831 0.4478973918860465 0.6542272507613758 1.0 0.8608453428419423 22 P35251,Q9NRF9,Q15054,P51530,Q9UQ84 5 O linked glycosylation of mucins 0.4873146102139581 0.4471673087983596 0.654754263317388 1.0 0.8608453428419423 3 Q10472 1 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.4300148588410122 0.4394811679290604 0.6603129245816295 1.0 0.865737672009384 2 P51659 1 Rna polymerase i transcription termination 0.3465499729329674 0.4393575848412438 0.6604024549302352 1.0 0.865737672009384 12 O15446,Q9GZS1,P52434,O95602 4 Rab geranylgeranylation 0.2873795365783955 0.4192843232008207 0.6750083522762718 1.0 0.8742728105128096 25 P61020,Q9ULC3,Q14964,Q9NP72,Q969Q5,Q15286,P62820,P51151,P61026,P20339 10 Degradation of cysteine and homocysteine 0.4773896272718666 0.4143140130326244 0.6786441526417277 1.0 0.8766898625030747 3 Q9UBX3 1 Trna processing in the nucleus 0.2576142330692916 0.4130872686910413 0.6795426767591097 1.0 0.8766898625030747 43 P52948,P35658,P49790,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q8NFH4,O15504,Q99567,Q8NFH5,Q52LJ0,A8CG34,Q9BTX1 14 Processing of capped intronless pre mrna 0.3042569719029352 0.406451833301534 0.6844106411693895 1.0 0.8791514548964529 19 P62304,Q86U42,Q9C0J8 3 Signaling by flt3 fusion proteins 0.4423868646484564 0.403967597351976 0.686236546842252 1.0 0.8798868600607505 5 Q14789,Q15643 2 Nr1h2 and nr1h3 mediated signaling 0.441250664490075 0.399952682576577 0.68919136829748 1.0 0.8807977166017354 5 Q8NB78 1 Complex i biogenesis 0.2662235885929748 0.3967399074684967 0.6915592682904994 1.0 0.8826811024362374 31 O95182,O95299,O43678,Q9BQ95,Q9NX14,Q9NPL8,O95168,Q9BU61 8 Transcriptional regulation by e2f6 0.3492167235694804 0.376392029399373 0.7066254707060597 1.0 0.8935776881850414 10 Q15022,P45973 2 Factors involved in megakaryocyte development and platelet production 0.2549710853184956 0.3741632595470623 0.7082828566222059 1.0 0.8935776881850414 47 Q9H0H5,Q14807,Q92667,Q02241,Q96N67,O60341,Q96Q89,P45973,Q96ST3,P27144,Q86Y91,P63000,Q9BVA1 13 Thrombin signalling through proteinase activated receptors pars 0.43091301207213 0.3641260309056016 0.7157638993285345 1.0 0.8976419828393912 5 Q14344,Q9UBI6 2 Influenza infection 0.2253422613582459 0.3555270388258301 0.722194792233561 1.0 0.9006418996173781 128 P26373,P62913,P50914,P46779,P40429,P84098,P46782,P61313,P62750,Q9BTX1,P35658,P24928,Q86U42,P52434,P61927,P83731,P62917,Q8NFH4,A8CG34,P62266,P62424,P12270,Q9UKX7,Q12849,Q8TEM1,Q8NFH3,P47914,P36578,Q02878,P52948,P62753,P52292,P49790,P61513,Q07020,Q99567,O15504,Q8NFH5 38 Trafficking of myristoylated proteins to the cilium 0.4568940327201516 0.3497601749230929 0.7265186892911859 1.0 0.9020154071449944 3 A6NIH7 1 Keratinization 0.3712468851756091 0.349620502076378 0.7266235224223567 1.0 0.9020154071449944 8 Q14126,Q02487,Q99959 3 Formation of the cornified envelope 0.3712468851756091 0.349620502076378 0.7266235224223567 1.0 0.9020154071449944 8 Q14126,Q02487,Q99959 3 Ion homeostasis 0.3355112207028066 0.3456602695126339 0.7295980460639269 1.0 0.9025159970693862 11 P05023,P20020,P17252,Q12797,P23634 5 Cardiac conduction 0.3355112207028066 0.3456602695126339 0.7295980460639269 1.0 0.9025159970693862 11 P05023,P20020,P17252,Q12797,P23634 5 Beta oxidation of lauroyl coa to decanoyl coa coa 0.4465879964898125 0.3411808703315351 0.7329674235061812 1.0 0.9038104030458768 4 Q16836,P55084 2 Chromosome maintenance 0.2499578966335539 0.3265263215004098 0.7440261779593731 1.0 0.9155238859377388 49 Q9NPE3,P16104,P35251,O60264,Q15554,P24928,Q9UER7,Q92674,P46100,P52434,P62805,P06748,Q15054,P51530,Q96T23,O60832,Q8WVB6 17 Transcriptional regulation of white adipocyte differentiation 0.3148119735619582 0.3206452259125352 0.7484792604445158 1.0 0.9177859228507426 13 O60244,Q9Y2W1,Q15648,Q14966 4 Synthesis secretion and deacylation of ghrelin 0.4411348989393959 0.3034509501975139 0.7615462222492466 1.0 0.9249229204480468 3 P67812 1 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.4411348989393959 0.3034509501975139 0.7615462222492466 1.0 0.9249229204480468 3 P67812 1 Phosphorylation of emi1 0.4330199518171773 0.3002889481353062 0.7639567625814117 1.0 0.9254489168803296 4 Q12834 1 Synthesis of bile acids and bile salts 0.4302705917335801 0.2922898506178648 0.7700650181997688 1.0 0.9272500158303536 4 P22059,Q96SU4,P51659 3 Bile acid and bile salt metabolism 0.4302705917335801 0.2922898506178648 0.7700650181997688 1.0 0.9272500158303536 4 P22059,Q96SU4,P51659 3 N glycan antennae elongation in the medial trans golgi 0.3863298662704328 0.2901936697208591 0.771668078783573 1.0 0.9272500158303536 2 Q16706 1 Reactions specific to the complex n glycan synthesis pathway 0.3863298662704328 0.2901936697208591 0.771668078783573 1.0 0.9272500158303536 2 Q16706 1 Pyruvate metabolism and citric acid tca cycle 0.247166421769241 0.2874599561048757 0.7737601589830607 1.0 0.9272500158303536 35 P31040,P23368,P11177,Q9H9P8,O43837,P51553,Q15120,P48735,P08559,P53597,P10515,P50213,P09622 13 Sema3a pak dependent axon repulsion 0.3550788770584954 0.2862804642885775 0.7746633194988355 1.0 0.9272500158303536 8 O14786,Q9UIW2 2 Respiratory electron transport 0.2453420765074772 0.2845218145324305 0.7760105189463429 1.0 0.9272500158303536 52 P31040,Q16134,P22695,O95182,O95299,O43819,O43678,O75251,Q9BQ95,P10606,Q9NX14,Q9NPL8,O95168,Q9BU61 14 Rhobtb2 gtpase cycle 0.2829988161151248 0.2823293358731166 0.7776909933665623 1.0 0.9284678186111 19 P62995,P38159,Q8WWQ0 3 Activation of anterior hox genes in hindbrain development during early embryogenesis 0.2877555116135685 0.2597054633396074 0.7950909780757507 1.0 0.938559766487266 17 P16104,Q15022,P24928,O75530,P52434,P62805,Q9UBL3 7 Gap junction degradation 0.3979773944080946 0.2593622477298349 0.79535575523965 1.0 0.938559766487266 5 P09496,Q96CW1,P50570,Q9UM54 4 Nrage signals death through jnk 0.3598796657112473 0.2589386313303488 0.7956825909052063 1.0 0.938559766487266 7 Q14344,Q9NY61 2 Phospholipid metabolism 0.2418335058727443 0.2566353037694437 0.7974603190459109 1.0 0.938559766487266 51 Q96N66,O00459,Q8WUK0,Q9NPH0,Q8IY17 5 Extra nuclear estrogen signaling 0.3065770719632288 0.2472112114313349 0.8047447690724459 1.0 0.9439111577090342 12 Q9UBI6,O00459,O43815,P63096 4 Assembly of the orc complex at the origin of replication 0.343744072662732 0.2447208301741419 0.8066725982221674 1.0 0.943931321318155 8 P62805 1 Glycerophospholipid biosynthesis 0.2441544760406773 0.2445835440029541 0.8067789071095341 1.0 0.943931321318155 32 Q8WUK0,Q9NPH0,Q96N66 3 Hdr through single strand annealing ssa 0.3044797067179179 0.2381556557276447 0.8117603692527273 1.0 0.94739115414034 12 O60934,Q92878,P51530,Q9UQ84 4 Homologous dna pairing and strand exchange 0.3044797067179179 0.2381556557276447 0.8117603692527273 1.0 0.94739115414034 12 O60934,Q92878,P51530,Q9UQ84 4 Estrogen dependent gene expression 0.2436725219688116 0.2358808574482452 0.8135251227110398 1.0 0.9478749147604149 31 P16104,O60216,Q15648,P24928,O60341,P52434,P62805,P17844,O14646,Q9UQE7,Q14683,Q8WVM7 12 Ca2 pathway 0.3711524502794899 0.2337913564274767 0.8151469602152899 1.0 0.9489770581610838 6 Q9UBI6,P17252,P09471 3 Mitochondrial trna aminoacylation 0.2854316999979786 0.2291149970129563 0.8187795375387572 1.0 0.9491267247451288 16 Q9BW92,Q9NP81,Q15046,Q5JPH6,Q5JTZ9 5 G protein mediated events 0.3020082143726515 0.2276349254515466 0.819930066080484 1.0 0.9491267247451288 12 P08754,P17252,P52292,P63096 4 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.2356920219228962 0.2272137658026906 0.8202575240465961 1.0 0.9491267247451288 62 P00846,P31040,Q16134,P22695,O95182,O95299,O43819,O43678,Q9BQ95,P10606,Q9NX14,Q9NPL8,O95168,Q9BU61 14 Sensory processing of sound by outer hair cells of the cochlea 0.2910332042947934 0.2238274504084458 0.8228915694680219 1.0 0.9491267247451288 14 P23634 1 Beta oxidation of very long chain fatty acids 0.4038962105200612 0.220837163675846 0.8252192254521638 1.0 0.9491267247451288 4 Q15067,O75521 2 Ion transport by p type atpases 0.3351636749195548 0.2149600472997213 0.8297984680131849 1.0 0.9491267247451288 8 Q9HD20,P23634,P20020 3 Smooth muscle contraction 0.3051014957752948 0.2131889925408698 0.8311795536050288 1.0 0.9491267247451288 11 P07355 1 Sema4d induced cell migration and growth cone collapse 0.3637687861771459 0.2119500028613846 0.832146040019845 1.0 0.9491267247451288 6 P35580 1 Meiotic recombination 0.3107155647165892 0.211535768227616 0.8324692246199283 1.0 0.9491267247451288 10 P16104,O60934,P62805 3 The citric acid tca cycle and respiratory electron transport 0.2148353923015453 0.2101591614815536 0.8335434521608285 1.0 0.9491267247451288 95 P31040,P11177,O75251,P48735,P53597,P50213,P23368,O95182,O43819,Q9H9P8,Q15120,P09622,Q9NX14,Q9NPL8,P00846,Q16134,P31930,O43678,O95168,O95299,O43837,P51553,P08559,P10515,Q9BQ95,P10606,P22695,Q9BU61 28 Regulation of tp53 activity through phosphorylation 0.2463640230261308 0.2096416258149239 0.8339473887842144 1.0 0.9491267247451288 28 Q9ULW0,Q92804,Q9Y3T9,P51530,Q9UQ84,O14965 6 Glucose metabolism 0.2330712674015567 0.2052919027674855 0.8373440699922436 1.0 0.9491267247451288 62 Q16822,Q9BTX1,Q9UBX3,P35658,Q8NFH4,A8CG34,P17252,O75746,P12270,Q9UKX7,Q8NFH3,Q8TEM1,P53007,P09104,P52948,P49790,O15504,Q99567,Q8NFH5 19 Dna double strand break repair 0.2354160123887058 0.2049830577785416 0.8375853619028293 1.0 0.9491267247451288 53 P16104,Q14676,P35251,Q12888,Q9UIG0,Q9NRF9,P62805,Q15054,Q9UQ84,O96028 10 Mismatch repair 0.2965166071336908 0.2048550550242394 0.8376853713365291 1.0 0.9491267247451288 12 Q9UQ84 1 Activation of nmda receptors and postsynaptic events 0.2561682586112113 0.1949206791544334 0.8454550450662546 1.0 0.9513199034682068 23 Q14168,P17252,Q12959,P63000,Q9BVA1,Q15334,O14936 7 Myogenesis 0.3546563522761221 0.186347807928918 0.8521720186775514 1.0 0.9545713219553492 6 P60953,Q92859,P35221,P35222,P19022 5 Tysnd1 cleaves peroxisomal proteins 0.3694229625223187 0.181811358382683 0.8557307703881982 1.0 0.9565652879180178 5 Q15067,P51659,O00116,P22307 4 Potential therapeutics for sars 0.2302665571822691 0.1737944640226992 0.8620269952558592 1.0 0.9628368347965204 36 Q99720,Q14839,O60341,O94776,P62942,Q86YP4,O95782 7 Trna processing 0.2295498268973439 0.1667223740243822 0.8675885000077002 1.0 0.9643702780835228 59 Q8WUM0,O15091,Q9BTX1,P35658,Q5VV42,Q8NFH4,O75648,A8CG34,Q7L0Y3,P49792,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q969Y2,Q9BVC5,P52948,P49790,O15504,Q99567,Q8NFH5,Q52LJ0 22 Esr mediated signaling 0.2266307199265269 0.1659569270243147 0.8681908472906452 1.0 0.9643702780835228 44 P16104,Q9UBI6,O60216,Q15648,P24928,O60341,O00459,Q9UQE7,P62805,O43815,P17844,O14646,P08754,P63096,Q14683,Q8WVM7 16 Hdl assembly 0.3384843982169412 0.1639425035474015 0.8697764067517799 1.0 0.9643702780835228 2 P17252 1 Pka mediated phosphorylation of key metabolic factors 0.3384843982169412 0.1639425035474015 0.8697764067517799 1.0 0.9643702780835228 2 P17252 1 Acyl chain remodelling of pc 0.3763376932223457 0.1487961115153911 0.8817145190436466 1.0 0.96960303371947 3 Q7L5N7,Q8NF37 2 Eph ephrin mediated repulsion of cells 0.2728549677557591 0.1480195017073749 0.8823273776377691 1.0 0.96960303371947 14 O95782 1 Translation of sars cov 1 structural proteins 0.3234806872327271 0.1476900596575031 0.8825873768472099 1.0 0.96960303371947 7 Q13724,Q10472,Q14697 3 Neurotransmitter release cycle 0.3222768144671085 0.144478058853231 0.8851229811615993 1.0 0.9713153026002652 7 P51649,Q96QD8 2 Repression of wnt target genes 0.3669342848647097 0.1381850987803633 0.8900941315634503 1.0 0.9725104571902744 4 P56545,Q13547,Q13363 3 Cd28 dependent vav1 pathway 0.3491969066032084 0.1352182219724171 0.8924393403557671 1.0 0.9725104571902744 5 P63000,P62993,Q16512,P60953 4 Signaling by tgf beta receptor complex 0.2525352494025147 0.1320808458625846 0.8949203459570161 1.0 0.9725104571902744 19 Q9P2M7,Q96PU5,Q9Y624 3 Type i hemidesmosome assembly 0.3656361474435105 0.1293043743935041 0.8971168102286553 1.0 0.9733786719946153 3 Q15149,P23229 2 Assembly of collagen fibrils and other multimeric structures 0.3656361474435105 0.1293043743935041 0.8971168102286553 1.0 0.9733786719946153 3 Q15149,P23229 2 Glycolysis 0.2243306901668986 0.1281140184727875 0.8980587423322317 1.0 0.9736482426520876 51 P52948,P35658,P49790,P17252,P12270,Q9UKX7,Q8NFH3,Q8TEM1,Q8NFH4,O15504,Q99567,Q8NFH5,A8CG34,Q9BTX1,P09104 15 Synthesis of pips at the golgi membrane 0.3151785714285737 0.1261796387249111 0.8995897284777288 1.0 0.9741510547690696 7 P42356,Q9BTU6,Q10713,Q01968,Q9NTJ5,O00443 6 Transcriptional regulation by runx1 0.2177530429720641 0.1253379345903718 0.9002560215021762 1.0 0.9741510547690696 69 P16104,Q9HC52,Q07157,Q03164,Q96GM5,Q8IXK0,P51532,P62805,Q86U86 9 Atf4 activates genes in response to endoplasmic reticulum stress 0.2676560179060515 0.1201253516272305 0.9043838501077988 1.0 0.9752341978120964 13 Q13868,Q92945,Q9Y3B2,Q15024,Q5RKV6,Q9NQT5 6 Signaling by tgfb family members 0.2447198575920522 0.1159050905494083 0.9077277612156718 1.0 0.9765898672389296 20 Q9P2M7,Q96PU5,Q9Y624 3 L1cam interactions 0.2185058456579079 0.1091416193775181 0.913090164550716 1.0 0.9774298368705144 45 Q12959,O14786,Q13740,O95782,P13591 5 Pi metabolism 0.243007272473099 0.1086497222854741 0.9134803214780348 1.0 0.9774298368705144 20 O00459 1 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.2345589407505191 0.1079122695345932 0.9140652842792144 1.0 0.9774298368705144 25 P52597,P20700,P11233,P22626,O14979,P07355 6 Golgi cisternae pericentriolar stack reorganization 0.2738379022646012 0.1020123905073427 0.918746840191006 1.0 0.9774298368705144 11 P06493,Q9H0U4,P27361,O60763,Q08379,P62820,P28482,Q9H8Y8,P53350,P61019 10 Role of abl in robo slit signaling 0.3425023297410895 0.0954400744495345 0.9239652865290068 1.0 0.9781950975128284 4 Q9Y6N7 1 Cdc6 association with the orc origin complex 0.3413618792744682 0.0936770526893372 0.9253656994043182 1.0 0.9781950975128284 4 Q13416,Q9UBD5,Q9UJA3 3 Interleukin 12 signaling 0.226523901204025 0.0907089989021282 0.9277238200233882 1.0 0.9781950975128284 27 P52597,P20700,P11233,P22626,O14979,P07355 6 Trafficking of glur2 containing ampa receptors 0.2989429636455508 0.0885020295180763 0.9294776713483316 1.0 0.9781950975128284 7 O95782 1 Robo receptors bind akap5 0.3385850178359021 0.0878737521601137 0.9299770186259207 1.0 0.9781950975128284 3 P17252,P13861 2 Plasma lipoprotein assembly 0.3385850178358992 0.0878737521601101 0.9299770186259236 1.0 0.9781950975128284 3 P07237,P17252 2 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.2784481400363633 0.0767210476911043 0.9388454602530972 1.0 0.9829522939562628 9 Q12834 1 Maturation of sars cov 2 spike protein 0.2551859238747518 0.0626362980859085 0.9500561244610488 1.0 0.9880583694394908 12 Q13724,P27824,P04843,Q14697,P39656 5 Rhobtb3 atpase cycle 0.3092476955099697 0.0522228483285787 0.9583511274379202 1.0 0.9944752275852476 4 P51151,O60664,Q13618 3 Aquaporin mediated transport 0.2857350803996352 0.0446157682655156 0.9644135739169836 1.0 0.9979218505617632 6 Q9UBI6,P17252 2 Pyrimidine salvage 0.2966706302021349 0.0444877269508387 0.9645156347666044 1.0 0.9979218505617632 3 P04183,P27707 2 Epha mediated growth cone collapse 0.2555853440572052 0.0401732479256245 0.9679550054698196 1.0 1.0 10 Q7Z406,P07947,P35579,O75116,P07948,P35580,Q15375,P60660,P29317 9 Hur elavl1 binds and stabilizes mrna 0.2799670855895175 0.0369199965865089 0.9705487956454596 1.0 1.0 6 P35658,Q15717 2 E2f enabled inhibition of pre replication complex formation 0.2734305266289828 0.0289238969397747 0.9769252865910762 1.0 1.0 6 P06493,Q13416,Q9Y619,Q9UBD5,Q9UJA3 5 Perk regulates gene expression 0.2312052505966564 0.0218502908525674 0.98256737744869 1.0 1.0 15 O95453,P05198,Q9NQT4,Q13868,P08243,Q92945,Q96B26,Q9Y2L1,Q15024,Q9Y3B2,P25208,Q06265,Q5RKV6,Q9NQT5 14 Sensory processing of sound 0.2203785525565578 0.0171712333145093 0.986300011294858 1.0 1.0 19 P23634 1 Telomere maintenance 0.2003468132884403 0.0161544608322788 0.9871111657088224 1.0 1.0 44 Q9NPE3,P16104,P30876,P35251,Q15554,P24928,Q9UER7,P46100,P52434,Q9NX24,P62805,Q15054,P51530,O60832,Q8WVB6 15 Interferon signaling 0.2019104058630163 0.0118607336826678 0.9905367255928396 1.0 1.0 68 P35658,P49790,P04439,P29372,P12270,Q9UKX7,Q8NFH3,Q8TEM1,P13591,O15504,Q99567,Q8NFH5,P55265,A8CG34,P19474,Q9BTX1 16 Netrin 1 signaling 0.2411627561416614 0.0097832845542952 0.9921941928194756 1.0 1.0 10 O94813,Q9Y6N7 2 Regulation of kit signaling 0.2537180249851199 0.0096881532815549 0.9922700929960612 1.0 1.0 5 P62993,P07947,P17252,P07948 4 Vasopressin regulates renal water homeostasis via aquaporins 0.2381873538568631 0.0016270466477963 0.9987018051727984 1.0 1.0 5 Q9UBI6 1 Glucagon signaling in metabolic regulation 0.2381873538568631 0.0016270466477963 0.9987018051727984 1.0 1.0 5 Q9UBI6 1 The role of nef in hiv 1 replication and disease pathogenesis 0.2290119814911997 0.0013595382021209 0.9989152457928724 1.0 1.0 12 O95782,P04439 2