File size: 61,093 Bytes
d5cde04
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
Organic anion transporters	0.9028520499108744	3.8913417306352103	9.969140850296654e-05	0.1306189129957761	0.0015833642067921	2	Q9UBX3	1
Formation of fibrin clot clotting cascade	0.8924539512774845	3.842364794547578	0.0001218545431169	0.1572578191524127	0.0018008818793287	2	P42785	1
Intrinsic pathway of fibrin clot formation	0.8924539512774845	3.842364794547578	0.0001218545431169	0.1572578191524127	0.0018008818793287	2	P42785	1
Urea cycle	0.8793820558526457	3.780360522670424	0.0001566014297122	0.1973894086742673	0.0022821290278041	2	P78540	1
Synthesis of pe	0.8553178847296543	3.664925827585591	0.0002474102750182	0.2934822857540514	0.0032463927675297	2	Q9UG56	1
Regulation of commissural axon pathfinding by slit and robo	0.8493761140819978	3.636160746934308	0.0002767316822129	0.3219844466120618	0.003564507172725	2	O94813	1
Slc mediated transmembrane transport	0.7000631373515913	3.4907882750950137	0.0004815977418821	0.4915183248635486	0.0052415754232756	28	O00400,Q70HW3,P04920,P11166,P08195,Q9UPY5,Q6PCB8,P55011,Q9UBX3	9
Synthesis of pg	0.906085901809526	3.34915099912114	0.0008105960566222	0.6797131803476526	0.0080146257992792	3	Q8WUK0	1
Other semaphorin interactions	0.7840166369578161	3.312566930969472	0.0009244400339509	0.7270629507988553	0.0089115937606223	2	Q9UIW2	1
Metabolism of lipids	0.3796637601194777	3.3047062875236826	0.0009507597915323	0.7369738227871274	0.0089115937606223	191	P04035,P35610,O43772,Q8NBJ7,Q9UBM7,Q5T8D3,Q9UMR5,Q15165,P37268,Q86UL3,Q9BWD1,Q8NCC3,O95864,P50416,Q10713,P10619,Q16850,Q9NPH0,Q9BVG9,Q9UG56,P48449,Q9NZJ7,Q15392,O75845,O00459,Q9Y6X9,P33527,P53007,Q96N66,Q06136,O00767,Q96G23,P34913,Q14739,Q8WUK0,P42765,P16219,Q9H7Z7,Q14534,Q8IV08	40
Transport of small molecules	0.3950162536003674	3.2316036720514085	0.0012309766082907	0.8226013421494025	0.0107441432672289	164	P27105,O00400,P08183,P35610,Q9UPY5,P09601,P04920,Q8WTV0,Q10713,O15439,Q9BUN8,P28074,P55011,Q8TDW0,Q70HW3,P33527,Q9C0H2,P11166,P08195,P30519,P49721,P02792,Q9UBX3,Q6PCB8,P01130	25
Rrna modification in the mitochondrion	0.7670825906120093	3.226492142351794	0.0012531767286141	0.828052057202503	0.0108608649813225	2	Q9HC36	1
Glycerophospholipid catabolism	0.7554961378490826	3.167046543054441	0.0015399566935778	0.8851083396349625	0.0130246939625501	2	Q8IY17	1
Diseases associated with o glycosylation of proteins	0.8631005053000776	3.157093235175148	0.0015935038677361	0.8934417913399854	0.0133171394660807	3	O43505	1
Tp53 regulates transcription of genes involved in cytochrome c release	0.9694947264174412	3.137915228070266	0.0017015407995673	0.908461721537289	0.0137296740378878	4	Q13625	1
Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip	0.856463595839525	3.127015515116146	0.0017659060791253	0.9163842893036755	0.0140871144039313	3	P67812,P61009	2
Synthesis secretion and deacylation of ghrelin	0.856463595839525	3.127015515116146	0.0017659060791253	0.9163842893036755	0.0140871144039313	3	P67812,P61009	2
Adrenaline noradrenaline inhibits insulin secretion	0.8459302289834172	3.079041351896777	0.0020766785472869	0.9459955224961448	0.0161333595484513	3	P63096	1
Cytochrome p450 arranged by substrate type	0.8277028672219882	2.995325951136593	0.0027415170895217	0.9788131766302786	0.0198406700705594	3	Q16850	1
Plasma lipoprotein remodeling	0.7201426024955486	2.982811453672619	0.0028561388442276	0.9819706888827544	0.0203554260776426	2	Q9BU23	1
Slc transporter disorders	0.5697198058858478	2.8778256965909725	0.0040042632100745	0.9964231460158348	0.0256711668810257	35	O00400,O15504,P11166,P49790,P08195,A8CG34	6
Runx3 regulates p14 arf	0.6981580510992356	2.866019700895049	0.004156683769271	0.9971147591489772	0.0264071674753689	2	P25440	1
Activated notch1 transmits signal to the nucleus	0.9009343693596168	2.856286014081785	0.0042862882289405	0.9975966290823176	0.0271078769073534	4	P78536	1
Tgf beta receptor signaling in emt epithelial to mesenchymal transition	0.7899096455174022	2.818860634103869	0.0048194438268347	0.9988669669112178	0.0296776277757718	3	Q9P2M7	1
Cholesterol biosynthesis	0.7193801847046101	2.8030875629662937	0.0050615925035282	0.9991948821046528	0.0310326457421555	17	Q14739,O75845,Q16850,P48449,Q9UBM7,P37268,Q9BWD1,Q15392	8
Acyl chain remodeling of cl	0.6791443850267445	2.7635949961614914	0.0057168448632407	0.999680732417726	0.0343010691794445	2	P40939	1
Notch3 activation and transmission of signal to the nucleus	0.7607926999937626	2.6801799477034467	0.0073582592255663	0.9999686153775108	0.0423401473471111	3	P49768	1
Noncanonical activation of notch3	0.7607926999937626	2.6801799477034467	0.0073582592255663	0.9999686153775108	0.0423401473471111	3	P49768	1
Proton coupled monocarboxylate transport	0.7515854651071485	2.635822830339906	0.0083933542623331	0.9999927463273108	0.0471370775372628	3	Q6PCB8	1
Regulated proteolysis of p75ntr	0.8480511903314516	2.632036049367107	0.0084874856584789	0.9999936514753152	0.0474758161932445	4	P78536	1
Sirt1 negatively regulates rrna expression	0.7331352154531956	2.546197997721667	0.0108903398494111	0.9999997895259444	0.0576195208430873	3	O43159,P62805	2
O linked glycosylation of mucins	0.7300078723930021	2.530908289037804	0.0113767590922924	0.9999998944968624	0.0585090467603609	3	O43505	1
G protein activation	0.6327985739750528	2.5082825960473487	0.0121319597781544	0.9999999639167968	0.0608331126018885	2	Q9UBI6	1
Adp signalling through p2y purinoceptor 1	0.6327985739750528	2.5082825960473487	0.0121319597781544	0.9999999639167968	0.0608331126018885	2	Q9UBI6	1
Rrna modification in the nucleus and cytosol	0.4408992229337475	2.359214465130747	0.0183136683910285	0.999999999994633	0.0788723632546137	56	P78316,O00567,Q9BVJ6,P55769,Q9Y2X3,O60832,Q9NV06,Q9NPE3,Q9H6R4,Q969X6,Q8TCT8,O43818,Q9Y3A2,Q9H0A0,Q9BVI4,Q96G21,Q9Y5J1,Q14690,O15213,Q9Y2R4,P46087,P22087,Q9H0S4,Q14692,O43709,O00566	26
Transport of inorganic cations anions and amino acids oligopeptides	0.7141555161451953	2.3540229195020026	0.0185714659628111	0.9999999999962882	0.0796431581792991	12	P04920,Q70HW3,P08195,Q9H936,Q9UPY5,Q96QD8,P55011,Q9UBX3,Q9H2J7	9
Incretin synthesis secretion and inactivation	0.78098066218779	2.338467151402031	0.0193630277752172	0.9999999999988044	0.081638711700916	4	P67812,P61009	2
Synthesis secretion and inactivation of glucagon like peptide 1 glp 1	0.78098066218779	2.338467151402031	0.0193630277752172	0.9999999999988044	0.081638711700916	4	P67812,P61009	2
Rrna processing	0.3425438521505949	2.3314021100029727	0.0197321663800469	0.9999999999992952	0.0824522666594818	164	P84098,P46782,O00567,P47914,Q13868,Q9BVJ6,Q9BV38,Q13601,P83881,P56182,Q9NRX1,P62266,P62917,Q99714,Q9Y221,Q99848,O00541,O15091,Q9Y2R4,Q96EU6,O43709,P40429,P42766,Q9NQZ2,P78316,P18077,P18621,P46777,Q7L0Y3,Q9HC36,Q9BQ52,Q9NV06,Q07020,Q9NPE3,Q9H6R4,Q9Y2P8,Q15024,P62910,P62424,Q8TCT8,Q9Y3A2,Q9BVI4,Q96G21,P36578,Q14690,P46776,O15213,P61353,Q9H0S4,O00566,Q02878,Q9NY93,Q8WVM0,P55769,Q9Y2X3,O60832,P61513,Q969X6,O43818,Q9H0A0,Q9NQT5,P61927,P61313,Q8IY81,P46087,Q8NI36,Q9NR30,Q9NW13,P26373,P46779,Q9BVP2,P62847,Q9H0D6,P39023,Q9Y3U8,Q12788,Q02543,P62913,P62273,P50914,Q9Y5J1,Q5SY16,P22087,Q14692,Q9GZL7,Q14137,Q2NL82	87
Constitutive signaling by aberrant pi3k in cancer	0.8364043999717685	2.32754370366239	0.0199363457543568	0.999999999999474	0.0828125131334824	6	P84095	1
Ptk6 regulates proteins involved in rna processing	0.6879717674606605	2.322608145090943	0.0202002127636315	0.9999999999996396	0.0834149962357022	3	O75525	1
Metabolism of steroids	0.4678064516500507	2.3168315330850686	0.0205129105872521	0.9999999999997696	0.0844578488695073	43	Q14739,O75845,P04035,Q16850,Q53GQ0,Q9UBM7,P48449,P37268,Q14534,Q9BWD1,Q15392,O00767	12
Gaba receptor activation	0.760018560074849	2.2445836507584622	0.0247948732959097	0.9999999999999996	0.0972402293504395	4	P63096	1
Adp signalling through p2y purinoceptor 12	0.760018560074849	2.2445836507584622	0.0247948732959097	0.9999999999999996	0.0972402293504395	4	P63096	1
Gaba b receptor activation	0.760018560074849	2.2445836507584622	0.0247948732959097	0.9999999999999996	0.0972402293504395	4	P63096	1
Signaling by notch1	0.7173342062612176	2.213213506002018	0.0268829293910188	1.0	0.1023468127128138	10	P78536	1
Egr2 and sox10 mediated initiation of schwann cell myelination	0.7314546334675415	2.210526408184612	0.0270686498206995	1.0	0.102437693661084	9	P04035,Q16850,P46939,P07942,Q14118	5
Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux	0.6648977665337391	2.206062135469227	0.0273796494329292	1.0	0.1027834968016916	3	Q8NB78	1
Signaling by notch1 pest domain mutants in cancer	0.7504423029458975	2.176352693111475	0.0295288982511534	1.0	0.1088151526105497	8	P78536	1
Epigenetic regulation of gene expression	0.4423911821228877	2.141165220419265	0.032260716660827	1.0	0.1149495908966856	45	O00159,P16104,Q9NY93,Q8WXI9,Q14839,Q9H9Y6,P52434,Q96T88,P17480,Q09028,Q9GZS1,Q9UIG0,O15446,P62875,P62805,Q9H0E3,O60264,O43159,Q86YP4,O94776,O00422,Q9NR30,Q15022	23
Phase i functionalization of compounds	0.624852789008549	2.132043551736039	0.0330032664255326	1.0	0.116716841464604	15	P30837,O43169,Q16850	3
Nuclear signaling by erbb4	0.8055448503580647	2.1014296017139995	0.0356032717043204	1.0	0.1231206735784874	5	P78536	1
P75ntr negatively regulates cell cycle via sc1	0.5600118835413064	2.09073908463001	0.0365514593243272	1.0	0.1255833773651418	2	Q13547	1
Positive epigenetic regulation of rrna expression	0.4945858426203173	2.0680988475726227	0.0386307290569769	1.0	0.1302473361517981	29	Q9H9Y6,O00159,P16104,P62805,Q9GZS1,P52434,Q9NY93,Q9UIG0,O60264,Q86YP4,O15446,O94776,Q9NR30,Q14839,P62875,Q09028	16
Beta oxidation of pristanoyl coa	0.6326930076629504	2.0408075277192808	0.0412699620503334	1.0	0.1366580818836511	3	O15254	1
Interleukin 7 signaling	0.6299104541795202	2.0263900008752307	0.0427248348081572	1.0	0.1398267320994237	3	O00459	1
Glycerophospholipid biosynthesis	0.4763954075299452	2.01715711648831	0.0436791196781718	1.0	0.1422865058657848	32	Q8WUK0,Q9UG56,Q96N66,Q86UL3,Q8IV08,Q8NCC3	6
Attachment of gpi anchor to upar	0.782232483282016	2.003960077781597	0.0450743370877959	1.0	0.1440571007466765	5	Q9H490	1
Post translational modification synthesis of gpi anchored proteins	0.6860717498986046	1.9910564267122064	0.0464746841143983	1.0	0.1469604876049894	9	Q6YHK3,O43292,Q9H490	3
Phospholipid metabolism	0.4105339355174859	1.979897710255688	0.0477150237654684	1.0	0.1492024351151841	51	Q10713,Q8WUK0,Q9NPH0,Q9UG56,Q96N66,Q86UL3,Q8IV08,Q8NCC3	8
Tp53 regulates transcription of cell death genes	0.7749382153503854	1.9732602462427555	0.0484659196440766	1.0	0.1500297330221389	5	Q13625	1
Sumoylation of dna methylation proteins	0.6936169992339576	1.9405817960427816	0.0523090239025125	1.0	0.1574247072497089	4	Q8IXK0	1
Heme degradation	0.7668310241909468	1.9390280507593836	0.052497922615641	1.0	0.157493767846923	5	P33527,P09601	2
Binding and uptake of ligands by scavenger receptors	0.6742065588488213	1.9328661919448096	0.0532526836080977	1.0	0.1590373317989427	9	Q8WTV0	1
Sumoylation of dna damage response and repair proteins	0.4162121608954836	1.9209611152593424	0.0547366099011961	1.0	0.1614500006329398	46	P35658,Q9UQE7,Q9UKX7,O15504,P49790,Q8N3U4,A8CG34,Q8NFH4,Q96SB8,Q14676,Q9BTX1,Q8IXK0,Q01831,Q9NRG9,Q9HC52,P52948,P49792,P37198,Q06587,Q8WVM7,O60216,P12270,P42771,Q14683	24
Egfr transactivation by gastrin	0.5303030303030425	1.914558089504713	0.0555488842956637	1.0	0.1631071655875335	2	P17252	1
Shc1 events in erbb2 signaling	0.5303030303030425	1.914558089504713	0.0555488842956637	1.0	0.1631071655875335	2	P17252	1
Peptide ligand binding receptors	0.7123165189710368	1.8905806592132377	0.05868034405291	1.0	0.1708595850790589	7	P07602,P22466,Q9NZJ7,P04083,P42892	5
Class a 1 rhodopsin like receptors	0.7123165189710368	1.8905806592132377	0.05868034405291	1.0	0.1708595850790589	7	P07602,P22466,Q9NZJ7,P04083,P42892	5
Dna methylation	0.6814991120533234	1.8840573502299185	0.0595572184085777	1.0	0.1717219531873582	4	P62805,Q96T88	2
Amino acid transport across the plasma membrane	0.7331945270672366	1.8840033402746144	0.0595645236483215	1.0	0.1717219531873582	6	P08195,Q9UPY5,Q15758,Q96QD8,Q9H2J7	5
Fatty acid metabolism	0.3888177173608043	1.8764050192421975	0.0605996858936919	1.0	0.1731349449584339	60	P33527,O43772,Q5T8D3,Q9UMR5,P53007,P42765,Q15165,Q9H7Z7,P16219,Q9Y6X9,P50416,P34913,O95864,O00767	14
Processing of capped intron containing pre mrna	0.3010119144126843	1.866953870433254	0.0619080299949987	1.0	0.1759491378805228	196	Q14103,O94992,Q9BUJ2,Q9Y2W2,P22626,O95777,P67809,P17844,P19387,Q96QD9,Q9HCS7,Q9NRG9,Q9C0J8,Q9NW64,P82979,Q15427,Q8IX12,P52948,Q6P2Q9,P62304,Q8NI27,P12270,Q9BZJ0,Q99459,Q8WWY3,Q96DI7,Q00839,P52434,O95400,A8CG34,P51991,Q9Y3Y2,Q9BTX1,Q6UN15,P07910,Q9UNP9,O75400,O43390,P09234,Q7L014,P62995,P49792,Q08211,P37198,P33240,Q9P013,O75494,Q8IYB3,Q13243,Q86U42,P55769,Q9UBB9,Q9UKX7,O15504,O43395,O75152,Q86XP3,Q96BP3,Q9UMS4,Q13242,O60508,O75934,P14866,P24928,P62875,O43290,Q16629,Q96LT9,Q9UQ35,P35658,Q13151,Q9ULR0,O94913,P49790,Q8NFH4,P41223,Q15428,Q07955,P09651,O43660,P08621,Q9BY77,Q9BUQ8,Q9HCE5,Q15637,O60306,Q9Y5S9,Q13247	88
Role of phospholipids in phagocytosis	0.6772900071665304	1.8643519991033897	0.0622722889822044	1.0	0.1766268560222527	4	O00459,Q8IV08	2
Mitochondrial protein import	0.4487250289140016	1.8584777525756808	0.0631011998250117	1.0	0.1786171059562832	34	O60830,Q99595,Q9NS69	3
Cdc6 association with the orc origin complex	0.6758331106412525	1.8575229031855611	0.0632367958082147	1.0	0.1786407672328641	4	Q13416,Q9Y619	2
Mitochondrial translation	0.3886765533838373	1.8421183008316568	0.0654578474186	1.0	0.1836528331687083	58	O60783,P82930,Q13405,Q9BYD1,Q8TAE8,Q7Z2W9,Q13084,Q96A35,Q9BYC9,Q9BYD6,Q9HD33,Q9Y2R5,O75616,Q9Y2R9,P43897,Q15070,Q5T653,Q9BRJ2,Q9NVS2	19
Ret signaling	0.6945183479674638	1.809134729618228	0.0704300747632336	1.0	0.1931324706398046	7	Q9NR12	1
G alpha z signalling events	0.7274435766289417	1.7711178067075688	0.0765411134901548	1.0	0.205083441488888	5	P63096	1
Runx1 interacts with co factors whose precise effect on runx1 targets is not known	0.5500679558066355	1.767753525044056	0.0771021175323229	1.0	0.2061930914578695	16	P51532,Q68CP9,Q86U86,Q8TAQ2,Q9HC52,Q96GM5,Q8IXK0	7
O linked glycosylation	0.7225542755264593	1.7500982448734068	0.0801013625763644	1.0	0.2134009735431038	5	O43505,Q14118	2
Dna damage telomere stress induced senescence	0.536547969888215	1.730015089667318	0.0836275792632412	1.0	0.2194637781039079	17	O60934,P49959,P16104,P16403,Q96L91,P62805,P10412,Q15554,P07305	9
B wich complex positively regulates rrna expression	0.5207920067613149	1.7279925925098871	0.0839895524316429	1.0	0.2200024843545274	19	Q9H9Y6,O00159,P16104,P62805,Q9GZS1,P52434,Q9NY93,Q9UIG0,O15446,Q9NR30,P62875	11
Trna processing in the mitochondrion	0.6453626634958308	1.7137339175080044	0.0865776047305342	1.0	0.2242711384532657	4	Q99714,O15091,Q7L0Y3	3
Nuclear envelope breakdown	0.4040013756257598	1.7017440468637897	0.0888033595232193	1.0	0.2279340343155393	42	Q8TD19,P20700,Q9UKX7,O15504,P49790,A8CG34,P42166,Q8NFH4,Q9BTX1,P53350,Q9NRG9,P42167,Q8NC56,P50402,Q9Y2U8,P52948,P49792,P37198,P02545,P12270,P35658	21
Inactivation of cdc42 and rac1	0.6408468288486289	1.6922752480706929	0.090593504938071	1.0	0.2316817503334276	4	O94813	1
Sumoylation of chromatin organization proteins	0.4188812122585716	1.6879944222324288	0.0914122996596873	1.0	0.2333506704040018	37	P45973,O15504,P62805,P49790,A8CG34,P12270,Q8NFH4,Q9HC52,Q9BTX1,Q8IXK0,Q15022,Q9UKX7,Q969R5	13
Activation of gene expression by srebf srebp	0.5137656383236445	1.6826652194750913	0.0924399183486492	1.0	0.2351189227563471	19	Q16850,P48449,Q9UBM7,P37268,Q14534,O00767,O75845	7
Regulation of mecp2 expression and activity	0.603883587690059	1.641203042825404	0.1007552743077355	1.0	0.2530126226827109	10	Q14739	1
Synthesis of bile acids and bile salts	0.6232856115165137	1.608493879445931	0.1077270556136893	1.0	0.2634996273198952	4	P22059	1
Bile acid and bile salt metabolism	0.6232856115165137	1.608493879445931	0.1077270556136893	1.0	0.2634996273198952	4	P22059	1
G alpha s signalling events	0.6878628118409021	1.5999502153169185	0.1096096281561966	1.0	0.2671734686307294	5	P63096	1
Regulation of cholesterol biosynthesis by srebp srebf	0.452126535032632	1.583074968066308	0.113404378259037	1.0	0.2740443151044544	25	Q16850,P48449,Q9UBM7,P37268,Q14534,O00767,O75845	7
Meiotic synapsis	0.5122087449580893	1.5788510444332773	0.1143702272465754	1.0	0.275903434801017	17	Q9BTC0,P02545,P62805,P16104,Q8WVM7,Q9UH99,Q15554,Q9UQE7,Q14683	9
Regulation of insulin secretion	0.536169312939425	1.540501387409786	0.1234381848750101	1.0	0.2870501282339858	14	Q9UBI6,O43865,P11166,P63096	4
Wax and plasmalogen biosynthesis	0.6061236623067695	1.526152146401244	0.126971977883751	1.0	0.2874588138027406	4	Q8WVX9,O00116,O15228	3
Disinhibition of snare formation	0.5355126300148603	1.525456624316947	0.1271452445665968	1.0	0.2874588138027406	3	Q12846,P17252	2
Beta oxidation of butanoyl coa to acetyl coa	0.6037896097468546	1.5149218211392166	0.1297922035761818	1.0	0.2915652061135348	4	Q16836,P16219	2
Peptide hormone metabolism	0.5071249757703251	1.5059864460995689	0.132070653121068	1.0	0.2925200080450596	16	P61009,Q15005,O75787,Q9NV70,P67812,Q9Y4I1	6
Sumoylation	0.3281709691202378	1.5059751493580216	0.1320735531882162	1.0	0.2925200080450596	80	Q14683,P09874,P06748,P35658,Q9UQE7,Q9UKX7,Q9Y2X3,O15504,P49790,Q8N3U4,Q8NFH5,P17844,P11388,A8CG34,Q96ST3,Q8NFH4,Q96SB8,Q14676,Q9BTX1,Q8IXK0,Q969R5,Q01831,Q9UER7,P45973,Q9NRG9,P07910,Q9HC52,P52948,P49792,P37198,Q06587,Q12888,Q96EE3,P62805,Q8WVM7,P12270,O60216,Q9NQS7,P42771,Q15022,Q15424	41
Rrna processing in the mitochondrion	0.6457465794170304	1.4933696968948678	0.1353404406459755	1.0	0.2981658407060862	6	Q9HC36,Q8WVM0,Q99714,O15091,Q7L0Y3	5
Regulation of pyruvate dehydrogenase pdh complex	0.5839011904178415	1.480480031524963	0.138745185862275	1.0	0.3038974117794604	9	P11177,O00330,Q15120,P09622,Q8NCN5	5
Dissolution of fibrin clot	0.5265603317916709	1.4769535866860304	0.1396880791145474	1.0	0.3054860795589167	3	P60903	1
Gpvi mediated activation cascade	0.6417346854728685	1.4752008727754855	0.1401585468943227	1.0	0.3055848236688859	6	P84095	1
Metabolism of porphyrins	0.5603381939103196	1.4738140329528184	0.1405316689361755	1.0	0.3055848236688859	11	P30519,P33527,P09601	3
Rna polymerase i transcription initiation	0.4666901751202842	1.473546098148255	0.1406038433690173	1.0	0.3055848236688859	21	Q9H9Y6,Q9GZS1,P52434,Q86YP4,Q8WXI9,O15446,O94776,Q09028,P17480,Q14839,P62875,P32780	12
Anti inflammatory response favouring leishmania parasite infection	0.511857112847077	1.4703152157216766	0.1414764019569585	1.0	0.3070059788988714	15	P78536	1
Iron uptake and transport	0.4793579821422208	1.4589325701311764	0.1445836676288312	1.0	0.3113427444031887	19	P30519,P09601	2
Signaling by flt3 fusion proteins	0.6538131913401196	1.4511167710307733	0.1467473472603553	1.0	0.315035589531405	5	Q15643,Q01082	2
Metabolism of fat soluble vitamins	0.6122970706420126	1.4261665377593271	0.1538202761093068	1.0	0.3284994153774615	7	P01130	1
Adora2b mediated anti inflammatory cytokines production	0.5729823132066105	1.4248905969475811	0.1541888281579395	1.0	0.3284994153774615	9	P63096	1
Depolymerisation of the nuclear lamina	0.5610139355912709	1.4182832047987903	0.1561080981301008	1.0	0.3310812232245643	10	P02545,P42167,P50402,Q9Y2U8,P42166	5
Rna polymerase i transcription	0.4283862837373928	1.4060613302695264	0.159705913858271	1.0	0.3341626233497315	25	Q9H9Y6,P16104,P62805,Q9GZS1,P52434,Q86YP4,Q8WXI9,O15446,O94776,Q09028,P17480,Q14839,P62875,P32780	14
Mrna splicing	0.2919860376358211	1.3957848497782477	0.1627792939640997	1.0	0.3370827857309676	153	Q14103,O75494,Q99459,Q8IYB3,Q8WWY3,O94992,Q13243,Q96DI7,Q86U42,Q13151,Q9BUJ2,P55769,Q9ULR0,Q9Y2W2,O94913,Q9UBB9,P22626,O95777,O43395,P52434,P67809,O95400,P51991,Q86XP3,P41223,Q15428,Q9HCS7,Q07955,P09651,O43660,P08621,Q96BP3,Q9C0J8,Q9UMS4,Q9UNP9,Q13242,P09234,Q7L014,O60508,Q15427,O75934,P14866,Q9BUQ8,P24928,P62875,O43290,Q15637,Q16629,O60306,Q96LT9,Q9P013,Q9Y5S9,Q9UQ35	53
Trafficking and processing of endosomal tlr	0.4447415329768375	1.3914064358038285	0.1641022141359771	1.0	0.338325269672411	2	Q99538	1
Recognition and association of dna glycosylase with site containing an affected purine	0.635434923773711	1.3703416468574494	0.1705802783258074	1.0	0.347597548286551	5	P16104,Q15554,P62805	3
Prc2 methylates histones and dna	0.6164136736240722	1.3602067650371872	0.1737645023840166	1.0	0.3513440634327227	6	P62805,P16104,Q15022	3
Heparan sulfate heparin hs gag metabolism	0.5714961560957836	1.3589243517557743	0.1741705613598112	1.0	0.3513440634327227	4	Q7LGA3	1
Hdms demethylate histones	0.5968671895982307	1.353407425952502	0.1759255063959806	1.0	0.3539274715505986	7	O60341,Q8NB78,P62805	3
Protein protein interactions at synapses	0.4923613663017137	1.3533138218219067	0.1759553954005113	1.0	0.3539274715505986	15	Q9HCM4,O75955,O43491,O14936,Q9UJU6,P10586,Q12959,Q14168	8
Transport of bile salts and organic acids metal ions and amine compounds	0.5933853832579637	1.33696855677883	0.1812329006922688	1.0	0.3609233937190715	7	Q6PCB8,P35613,Q9H2J7	3
Negative epigenetic regulation of rrna expression	0.413966573904774	1.333547290048393	0.1823522673483135	1.0	0.3619714922886078	26	Q9H9Y6,P16104,P62805,Q9GZS1,P52434,O15160,Q9H0E3,O60264,O43159,O15446,O00422,P17480,P62875,P32780	14
Inhibition of dna recombination at telomere	0.5001593115431057	1.3307768329319074	0.1832624530310225	1.0	0.3623950479655712	14	Q9UER7,P62805,P52434,P46100,Q15554,P24928,P62875	7
Transport of mature transcript to cytoplasm	0.330008893826384	1.3087019904635695	0.19063531722428	1.0	0.3717388685873461	66	Q8IYB3,Q13243,Q9UKX7,Q10570,Q08170,O15504,P49790,O75152,Q96QD9,A8CG34,Q8NFH4,Q9Y3Y2,Q9BTX1,Q07955,Q6UN15,Q9NRG9,Q9C0J8,Q13242,P82979,O60508,Q9BY77,P52948,P49792,P37198,Q96EE3,Q16629,P12270,Q8NI27,Q86V81,Q9Y5S9,Q13247,P35658	32
Foxo mediated transcription of oxidative stress metabolic and neuronal genes	0.5603448275861967	1.3048642793225345	0.1919390664490028	1.0	0.3737620655955616	4	Q13547,P04179,Q96ST3	3
Formation of senescence associated heterochromatin foci sahf	0.5489879075805143	1.30238029531135	0.1927864151500584	1.0	0.3743736194615243	9	P10412,P16403,Q96L91,P07305	4
Sumoylation of rna binding proteins	0.3822838759564031	1.2935006839479988	0.1958379476699816	1.0	0.3797741416141633	34	Q9NRG9,O15504,Q06587,P49790,P07910,A8CG34,P12270,Q8NFH4,P35658,P37198,Q9HC52,P52948,Q9BTX1,Q8IXK0,Q9UKX7,Q9Y2X3,P49792	17
G alpha i signalling events	0.4168073878490712	1.2865660185897667	0.198245594263219	1.0	0.3833840417982914	24	P22466,Q9NZJ7,P04083,Q9UBI6,O43865,P63096	6
Signaling by erbb4	0.5444702891785582	1.2792830298684734	0.2007974063370605	1.0	0.3877848122382847	9	P78536	1
Free fatty acids regulate insulin secretion	0.4888035105639571	1.2713383782840446	0.2036082946089341	1.0	0.3909315266798501	3	O60488	1
Rna polymerase i promoter escape	0.4783725457375704	1.2691827734488244	0.2043758836061324	1.0	0.3909315266798501	15	Q9H9Y6,P62805,P16104,Q9GZS1,P52434,O15446,P17480,P62875,P32780	9
Base excision repair ap site formation	0.5946054883392831	1.2608783389214728	0.2073526835249888	1.0	0.3952462759283842	6	P16104,Q15554,P62805,P29372	4
Beta oxidation of lauroyl coa to decanoyl coa coa	0.5503146570375267	1.256200407852284	0.2090433189265659	1.0	0.3969588529176165	4	Q16836,P40939	2
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps	0.4360802794564383	1.2178004197013286	0.2232998248033915	1.0	0.4180172720319489	20	O43852,Q07065,Q02818,P07942,O43493	5
Ecm proteoglycans	0.5651858320261913	1.2037145945137804	0.2286999093734216	1.0	0.4249430614215831	7	Q14118,P07942	2
Beta oxidation of hexanoyl coa to butanoyl coa	0.5972896877994924	1.2022215014404103	0.2292777209145478	1.0	0.4252389962536659	5	P40939,Q16836,P16219	3
Ercc6 csb and ehmt2 g9a positively regulate rrna expression	0.4974666901252017	1.191232317827153	0.2335623957074042	1.0	0.4321794749176453	12	P62805,P16104,Q86YP4,O94776,Q14839,Q09028	6
Rna polymerase ii transcription termination	0.3372773303316588	1.1894792650474877	0.2342511256498063	1.0	0.4321794749176453	48	Q8IYB3,O94992,Q13243,Q86U42,O94913,Q10570,O75152,Q96QD9,Q9Y3Y2,Q07955,Q6UN15,Q9C0J8,Q13242,P82979,O60508,Q9BY77,P33240,Q16629,P62304,Q8NI27,Q86V81,Q9Y5S9,Q13247	23
Sumoylation of transcription factors	0.5345702552763834	1.1798104885683782	0.2380755970071435	1.0	0.4378231396545745	4	P42771	1
Cell cell junction organization	0.5249294984416437	1.179383153865246	0.2382456400969337	1.0	0.4378231396545745	9	Q92692,Q9Y624	2
Plasma lipoprotein assembly remodeling and clearance	0.441809755355642	1.1730760280220396	0.2407653186577263	1.0	0.4384148778199427	18	Q8WTV0,P35610	2
Basigin interactions	0.5399141273317429	1.1653616766008612	0.2438726230961165	1.0	0.4421068077107999	8	P05556,Q9UPY5,Q13356,P08195	4
Plasma lipoprotein clearance	0.4680843614322991	1.1434127818322088	0.252867248053684	1.0	0.4534171344410885	14	Q8WTV0,P35610	2
Cargo trafficking to the periciliary membrane	0.4103593232784143	1.1341574274298185	0.2567285182197074	1.0	0.4568401008624451	22	Q9NV70,A6NIH7	2
Activation of rac1	0.5653743266352719	1.1277485475105289	0.2594261285306354	1.0	0.4610560562746989	6	O94813,O96013	2
Extracellular matrix organization	0.3508598006864418	1.1258642264703775	0.2602229934790159	1.0	0.4613043975309827	39	O14936,P13591,Q14118,P13674,Q9Y624,P07942,O15484,O15446,O75718,P05556,P49768,P78536	12
P75 ntr receptor mediated signalling	0.4311592209934121	1.069794754054744	0.2847117041347977	1.0	0.495016928885946	17	P49768,P78536	2
Disorders of transmembrane transporters	0.2944436939456425	1.067853302552734	0.2855866897418919	1.0	0.495016928885946	80	O00400,O75477,O15504,P11166,P08195,P49790,Q9BUN8,A8CG34,P49721,P28074	10
Rna polymerase i transcription termination	0.4746166633534547	1.065293768033044	0.2867430120510379	1.0	0.4957970306892331	12	Q9H9Y6,Q9GZS1,P52434,O15446,P17480,P62875,P32780	7
Stimuli sensing channels	0.5002088108655189	1.053367841211051	0.2921724371276459	1.0	0.5014914062447492	9	P27105,Q96PU5,Q9C0H2	3
Leishmania infection	0.3314808055678348	1.0498577033312178	0.2937835405649471	1.0	0.5030147450648608	44	P78536,P09601,Q9UQB8	3
E2f enabled inhibition of pre replication complex formation	0.5476935128430864	1.0474983949381689	0.294869772066066	1.0	0.5042181912651026	6	Q13416,Q9Y619	2
Maturation of sars cov 2 spike protein	0.4707369209401547	1.04399061475315	0.2964897318466195	1.0	0.5051317284718091	12	P04843,P27824,Q16706,P14314,Q9H0U3,P39656,Q13724	7
Plasma lipoprotein assembly	0.4442793462109974	1.0287705147900597	0.3035875252333313	1.0	0.5098527337650683	3	P17252,P07237	2
Rhoa gtpase cycle	0.3175856040811027	1.0244125453676944	0.3056404588962418	1.0	0.5114932313162901	52	P27105,O75955,Q14739,P43121,P42167,P30519,Q07021,Q5T8D3,Q96HY6,Q86VI3,O00459,Q9H0H5,P51572	13
Rac3 gtpase cycle	0.3418153926948715	1.0240778358916949	0.3057985122190243	1.0	0.5114932313162901	38	Q14739,P43121,P42167,O96013,Q9Y2U8,Q14126,Q9UQB8,O00459,Q9H0H5	9
Signal regulatory protein family interactions	0.4430906389301652	1.0223306210313987	0.3066244450877398	1.0	0.5114932313162901	3	P62993,Q08722	2
Establishment of sister chromatid cohesion	0.5104561440935035	1.0212953567532312	0.3071145256407639	1.0	0.5114932313162901	8	Q8WVM7,O60216,Q9UQE7,Q9NTI5,Q14683	5
Maturation of sars cov 1 spike protein	0.5016170340510788	1.0204714609345582	0.3075049176044824	1.0	0.5115366164889731	4	P27824,Q13724	2
Insertion of tail anchored proteins into the endoplasmic reticulum membrane	0.4657462416987301	1.016636685833458	0.3093262954259155	1.0	0.5133500221962002	12	P46379,P09601	2
Gpcr ligand binding	0.4825848715797569	1.0080642423480624	0.3134236224065991	1.0	0.5183118561352947	10	Q9NZJ7,P22466,P04083,P42892	4
Cytoprotection by hmox1	0.3083414704261745	1.0070511642149786	0.3139101876580779	1.0	0.5185057687905192	62	P33527,P30519,Q8TCT9,P49721,P09601,P28074	6
Rac1 gtpase cycle	0.3155993784736373	1.0040000712204613	0.3153785792593708	1.0	0.5190990917704064	52	Q14739,P43121,P42167,O96013,P50402,Q9Y2I1,Q9Y2U8,Q86VI3,Q9UQB8,O00459,Q9H0H5	11
Abc family proteins mediated transport	0.3128632097875914	0.99923037217471	0.3176831059936817	1.0	0.52105967384945	56	P28074,P08183,P33527	3
Signaling by notch3	0.5335513364316722	0.9836186944134232	0.3253030298719306	1.0	0.5316943584868342	6	P49768	1
Synthesis of pa	0.4990998398104284	0.9661391226604142	0.3339745702551495	1.0	0.5445996476634494	8	Q86UL3	1
Sema3a plexin repulsion signaling by inhibiting integrin adhesion	0.5404878720401476	0.953116273221322	0.3405311618416919	1.0	0.5543191988721435	5	O14786	1
Meiosis	0.3674697238147882	0.9519555860670422	0.3411195069982422	1.0	0.5543191988721435	25	Q9BTC0,O60934,P02545,P16104,P62805,Q8WVM7,O60216,Q15554,Q9UH99,Q9UQE7,Q14683	11
Reproduction	0.3674697238147882	0.9519555860670422	0.3411195069982422	1.0	0.5543191988721435	25	Q9BTC0,O60934,P02545,P16104,P62805,Q8WVM7,O60216,Q15554,Q9UH99,Q9UQE7,Q14683	11
Pink1 prkn mediated mitophagy	0.4795358968781519	0.948786601739794	0.3427291575934599	1.0	0.5550077707741842	9	O95140,Q9NS69,Q8IWA4	3
Notch4 intracellular domain regulates transcription	0.3713606654783243	0.9358111220418072	0.3493704440480127	1.0	0.5638116131533447	2	Q04721	1
Degradation of the extracellular matrix	0.44933327840574	0.927176491415408	0.3538349064958734	1.0	0.5690862435687761	12	P49768,P78536,P07942	3
Signal amplification	0.5025678899228101	0.9099416047900628	0.3628533068389963	1.0	0.5774323531324491	7	P63096	1
Cell death signalling via nrage nrif and nade	0.4630472374552725	0.9071939148132128	0.3643042611067195	1.0	0.5786008852871428	10	P49768	1
Role of abl in robo slit signaling	0.4758118791080731	0.8970439302003859	0.3696954760286872	1.0	0.5825504470755072	4	O94813	1
Rora activates gene expression	0.4172354575762027	0.883294671676629	0.3770770819324514	1.0	0.5908663203495109	3	P50416	1
Processing of intronless pre mrnas	0.4002604695048711	0.8780835413817593	0.3798983840486447	1.0	0.5926414791158857	17	Q86U42,O94913,Q9C0J8	3
Transcriptional regulation by mecp2	0.4308878425512954	0.8763850217470976	0.380820758227208	1.0	0.5934210261387348	13	Q14739	1
Chl1 interactions	0.4142068365317659	0.8671746665243233	0.3858463146036501	1.0	0.5999205157292633	3	O14786	1
Miro gtpase cycle	0.519679498618214	0.8632511293790138	0.3879994075469111	1.0	0.6019349924816167	5	O95140,Q8IWA4	2
Hdacs deacetylate histones	0.4186964751472	0.8584160255305654	0.3906627816484813	1.0	0.6053979530181763	14	O60341,P62805,Q86YP4,O94776,O00422,Q14839,Q09028	7
Initiation of nuclear envelope ne reformation	0.4001665898336247	0.8497933850199558	0.3954399680155984	1.0	0.608769424445066	16	Q14739,P02545,P42167,P50402,Q9Y2U8	5
Carnitine metabolism	0.5031760657900837	0.8479517018349455	0.3964648692367172	1.0	0.6096787255294096	6	O43772	1
Transcriptional regulation by the ap 2 tfap2 family of transcription factors	0.5012285646605958	0.8393494206607206	0.4012732579672238	1.0	0.6100299376140862	6	O95619,P46087,Q6PL18,P06748	4
Sumoylation of ubiquitinylation proteins	0.3404995542299903	0.8382199433894124	0.4019071882428986	1.0	0.6100299376140862	28	Q9NRG9,O15504,P49790,A8CG34,P12270,Q8NFH4,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	12
Regulation of glucokinase by glucokinase regulatory protein	0.3404995542299903	0.8382199433894124	0.4019071882428986	1.0	0.6100299376140862	28	Q9NRG9,O15504,P49790,A8CG34,P12270,Q8NFH4,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	12
Sumoylation of sumoylation proteins	0.3404995542299903	0.8382199433894124	0.4019071882428986	1.0	0.6100299376140862	28	Q9NRG9,O15504,P49790,A8CG34,P12270,Q8NFH4,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	12
Regulation of ifng signaling	0.4074294205052026	0.8312644051666054	0.4058242781059564	1.0	0.6146464794614486	3	Q06124,P42224	2
Regulation of ifna signaling	0.4074294205052026	0.8312644051666054	0.4058242781059564	1.0	0.6146464794614486	3	Q06124,P42224	2
Arachidonic acid metabolism	0.4527512135285326	0.8153028501813265	0.414898977714488	1.0	0.6243495870430238	9	Q15165,P33527	2
Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3	0.4580298709077787	0.8132316059124961	0.4160852816658766	1.0	0.6247954389934661	4	O60341,P62805	2
Synaptic adhesion like molecules	0.4946213708633145	0.8102716220005097	0.4177840814878275	1.0	0.62646866807109	6	Q12959,P10586	2
Cohesin loading onto chromatin	0.4438994594668298	0.809735897843372	0.4180919814690964	1.0	0.62646866807109	10	Q8WVM7,Q6KC79,Q9NTI5,Q14683	4
Negative regulation of the pi3k akt network	0.4185820051962319	0.8086872624650691	0.4186950566692484	1.0	0.6264799858317609	13	P84095	1
Transcriptional regulation by small rnas	0.3128583605449827	0.8058458793443143	0.4203317203355219	1.0	0.6278146120756093	40	O15504,P62805,P49790,P52434,A8CG34,P12270,Q8NFH4,P35658,Q9BTX1,P24928,Q9UKX7,P62875	12
Regulation of pten gene transcription	0.3502937092011122	0.803168050576295	0.4218776092879066	1.0	0.6294539462701604	24	Q15382,O60341,Q06587,Q8N122,Q86YP4,Q8WXI9,Q9Y2Q5,O94776,Q9HC52,Q8IXK0,Q15022,Q14839,Q09028	13
Nuclear pore complex npc disassembly	0.3300764873035576	0.7982534547915555	0.4247234227127308	1.0	0.6320209175909025	31	Q9NRG9,O15504,P49790,Q8TD19,A8CG34,P12270,Q8NFH4,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	13
Sumoylation of transcription cofactors	0.4251273397001673	0.7972655100904861	0.4252968466290621	1.0	0.6320209175909025	12	Q9UER7,Q06587,P17844,P06748,Q96ST3,Q9HC52,Q8IXK0,Q15424	8
Metal ion slc transporters	0.3484848484848584	0.7970901190245634	0.4253986945323382	1.0	0.6320209175909025	2	Q15043	1
Zinc transporters	0.3484848484848584	0.7970901190245634	0.4253986945323382	1.0	0.6320209175909025	2	Q15043	1
Processing of capped intronless pre mrna	0.3747528819441195	0.7799966281586465	0.4353928598738161	1.0	0.6448223367751454	19	Q86U42,O94913,Q9C0J8	3
Cell surface interactions at the vascular wall	0.3654784198701321	0.7530888188926578	0.451396542883796	1.0	0.6623246407254717	20	Q13356,P08195,Q9UPY5,Q9Y624,P78310,P05556,O00459	7
Mitophagy	0.4167322047401923	0.7529893303738091	0.451456325622704	1.0	0.6623246407254717	12	O95140,Q9NS69,Q8IWA4	3
Regulation of hmox1 expression and activity	0.297049387296083	0.7423936424757187	0.4578488703274144	1.0	0.6696039728538435	45	P28074,Q8TCT9,P09601	3
Response to elevated platelet cytosolic ca2	0.3088044476321811	0.7372659162323745	0.4609606550698206	1.0	0.6734534440354092	38	O94919,O43852,P07602,Q6YHK3,O15439,Q9NZJ7,O75083,Q8NBX0,Q9UEU0,Q06481	10
Pyruvate metabolism and citric acid tca cycle	0.3117383421196503	0.7213331909573149	0.4707045406076149	1.0	0.6841295807588937	35	P53597,O00330,P11177,P31040,Q15120,P35613,P50213,P09622,Q9H9P8,Q99798,Q8NCN5,P21796,O43837,O95563,P23368,Q15118,Q13423,Q9P2R7	18
Nr1h2 and nr1h3 mediated signaling	0.4858275255455403	0.720212528855589	0.4713941510185506	1.0	0.6844233588728492	5	Q8NB78,O00767	2
Rab geranylgeranylation	0.3350058156136408	0.7179420515371663	0.4727930179172035	1.0	0.6855374952865161	25	P51151,P61020,P61026,Q969Q5,Q9NP72,Q15286,P62820	7
Cellular response to chemical stress	0.2706759814538942	0.7137384652652113	0.4753889163817952	1.0	0.6875326698106912	72	P33527,P30519,Q8TCT9,P49721,P09601,P28074	6
Interactions of vpr with host cellular proteins	0.3089906586036381	0.6990868896670037	0.4844977312355309	1.0	0.6955366203013145	35	Q9NRG9,O15504,P49790,O75475,A8CG34,P12270,Q8NFH4,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	13
Sumoylation of dna replication proteins	0.3071397364386944	0.6959760395234503	0.4864438352158076	1.0	0.6961948467308806	36	O15504,P49790,A8CG34,P11388,P12270,Q8NFH4,Q9NQS7,Q9BTX1,Q9UKX7	9
Interleukin 4 and interleukin 13 signaling	0.4032895436031596	0.6831813054832622	0.4944922840400394	1.0	0.7026995615305823	12	Q07820,P09601	2
Adherens junctions interactions	0.4506825235816297	0.6752889095133713	0.4994922286992502	1.0	0.706554303792902	7	Q92692	1
Cell cell communication	0.3156963099366943	0.67447962153879	0.5000064373219888	1.0	0.706554303792902	30	O14936,Q92692,Q13813,Q01082,Q9Y624,Q13418,P05556,P21333,O00459,P14923	10
Mitochondrial fatty acid beta oxidation	0.3599705296504706	0.6617747739320081	0.5081155752886228	1.0	0.7141276990354056	18	Q709F0,Q9Y305,P42765,P16219,P40939,P42126,Q16836	7
Neurexins and neuroligins	0.4173042705828154	0.6445640259946138	0.5192097537411782	1.0	0.724622757706376	9	Q9HCM4,O14936,O43491,Q9UJU6,Q14168	5
Phosphorylation of emi1	0.419568995931404	0.6375634205836708	0.5237579136179025	1.0	0.7281845823160634	4	Q12834	1
Flt3 signaling in disease	0.4415269905672148	0.6354555557737032	0.5251313444544898	1.0	0.7292625198952559	7	Q15643,Q01082	2
Mitotic prophase	0.2725816599464267	0.6337444757160633	0.5262475943596954	1.0	0.7300905360484312	63	P16104,Q8TD19,Q14980,Q9UKX7,O15504,P49790,A8CG34,P42166,Q8NFH4,Q9BTX1,P42167,P50402,Q9Y2U8,Q9H8Y8,P02545,P62805,P61019,P12270,Q08379,P35658,P62820	21
Met activates ptk2 signaling	0.3685679099773303	0.6313074762711035	0.5278394994844411	1.0	0.7308817113519277	3	P07942	1
Telomere extension by telomerase	0.3995002988116256	0.6262329366061723	0.5311621666606761	1.0	0.7318465966551415	11	Q9NPE3,Q15554	2
Synthesis of very long chain fatty acyl coas	0.4375242597952575	0.6182362695369602	0.5364196050106336	1.0	0.7372628200275378	7	Q53GQ0,O60488	2
Rhod gtpase cycle	0.3080456005348377	0.6178586473906066	0.5366685199915553	1.0	0.7372628200275378	30	Q14739,Q16643,P43121,P42167,P50402,Q9Y2U8,Q9UIW2,Q9BX68,O00459,Q9H0H5	10
Protein localization	0.2559051973479828	0.6111080875508227	0.5411280260103319	1.0	0.7419372544126035	76	O60830,P09601,Q99595,Q9NS69	4
Mitotic telophase cytokinesis	0.3795709615601136	0.6015837058074667	0.5474512777658511	1.0	0.7484144050469863	13	Q8WVM7,Q6KC79,O60216,Q9UQE7,P53350,Q9NTI5,Q14683	7
Rnd1 gtpase cycle	0.3514096546459445	0.5889061904108821	0.5559242048583308	1.0	0.7559601082650649	17	Q9Y2U8,O00459,Q15058	3
Aquaporin mediated transport	0.4402254949886187	0.5795026056174356	0.5622500889907429	1.0	0.7609990772264338	6	Q9UBI6	1
Class i peroxisomal membrane protein import	0.3813845594474563	0.573033848553258	0.5666217757929601	1.0	0.764963870212282	12	O75381,P56589,Q5T8D3,Q8NBU5,O96011	5
Rhoc gtpase cycle	0.2950559564953389	0.5730070746131033	0.5666399038609495	1.0	0.764963870212282	34	P27105,O75955,Q14739,P43121,P42167,Q07021,Q5T8D3,Q86VI3,Q9H0H5	9
Cdc42 gtpase cycle	0.2907616083064999	0.5558935696359162	0.5782836143935284	1.0	0.7776917572878485	35	P27105,Q14739,P42167,O96013,Q86VI3,Q9UQB8,O00459,Q9H0H5	8
Metabolism of steroid hormones	0.4304062876490243	0.540057358488594	0.5891574765652092	1.0	0.7892911231846887	6	Q53GQ0	1
Nuclear import of rev protein	0.2938712110020078	0.5374714999835156	0.5909419662038409	1.0	0.7901738290954216	32	P06748,Q9UKX7,O15504,P49790,Q8NFH5,A8CG34,Q8NFH4,Q9BTX1,P57740,Q9NRG9,Q5SRE5,P52948,P49792,P37198,P18754,Q96EE3,P12270,Q9BW27,P35658	19
Pre notch processing in the endoplasmic reticulum	0.3482912332838059	0.532714455065999	0.5942312583449365	1.0	0.7930614892740407	3	Q04721,Q9H488	2
Notch3 intracellular domain regulates transcription	0.3476968796433898	0.5299021057984783	0.5961798060699943	1.0	0.7949064080933258	3	P42224,Q13573	2
Immunoregulatory interactions between a lymphoid and a non lymphoid cell	0.4157006490832688	0.5267601552632507	0.5983601557240845	1.0	0.7963728213214092	7	P04439,Q92692,P78310	3
Retrograde transport at the trans golgi network	0.3217204046703564	0.5130747978432183	0.6078989998918201	1.0	0.8054128396596238	21	P53365	1
Regulation of tp53 activity through acetylation	0.3535600801831397	0.5071015670998733	0.612083555513188	1.0	0.8065619583795451	14	P55201,Q86YP4,O94776,O95696,Q14839,Q09028	6
Rnd2 gtpase cycle	0.324951309769188	0.5066653666751084	0.612389635065951	1.0	0.8065619583795451	20	Q9Y2U8,O00459,Q15058,Q9Y2I1	4
Rac2 gtpase cycle	0.2765279025029438	0.5021100715983566	0.6155900959527432	1.0	0.8100173333811166	40	Q14739,P43121,P42167,O96013,P50402,O00459,Q9Y2U8,P49257,P42166,Q9Y512,Q13112,Q9H0H5,P05556,Q14126,Q86XL3	15
Hiv transcription initiation	0.3382122136407673	0.4977883755959447	0.6186332100613505	1.0	0.8132593885076181	16	Q12962,P52434	2
Glycosaminoglycan metabolism	0.3578597357015837	0.4935501275773977	0.6216239297589803	1.0	0.8156635489547741	13	O43505,Q7LGA3,Q96L58,Q8NCH0	4
Transport of mature mrnas derived from intronless transcripts	0.2777936979958536	0.4878595309541681	0.6256493411136712	1.0	0.8182450129921299	38	Q6UN15,Q9NRG9,Q10570,O15504,Q9C0J8,Q96EE3,P49790,A8CG34,P12270,Q8NFH4,Q86V81,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	17
Rhoj gtpase cycle	0.3128622811313277	0.4874739950409131	0.6259224672033814	1.0	0.8182450129921299	22	P27105,Q14160,P42167,O96013,Q13112,Q86VI3,Q15758,O00459,P14923	9
Mrna splicing minor pathway	0.2826085021122049	0.4810991004430682	0.6304460673899719	1.0	0.8218719930433875	34	P24928,Q6P2Q9,Q13247,P52434,P67809,Q16629,P19387,Q96DI7,Q96LT9,Q86XP3,P55769,Q15427,Q9BUQ8,Q07955,P62875	15
Traf3 dependent irf activation pathway	0.2923351158645378	0.4794425257589478	0.6316238465055664	1.0	0.8218719930433875	2	Q7Z434	1
Synthesis of pc	0.420182626960524	0.4623949724429181	0.643798104016875	1.0	0.834619148697777	5	P35790	1
Pyruvate metabolism	0.3300962852088462	0.4557179205462182	0.6485928336806053	1.0	0.8400593528483117	16	P11177,O00330,Q15120,P09622,Q8NCN5,O95563,Q15118,P35613	8
Formation of xylulose 5 phosphate	0.3313521545319487	0.4545805898070839	0.6494110015389669	1.0	0.8403438213462762	3	Q00796,P14550	2
Activation of nima kinases nek9 nek6 nek7	0.3752758566383239	0.4504991837870952	0.6523505425857874	1.0	0.8425944450694071	4	Q8TD19	1
Hemostasis	0.2309212683755415	0.4391609215173655	0.6605449386222504	1.0	0.8488717835572064	134	P60903,Q13356,O43852,Q92667,Q9UPY5,P42785,Q8N2K0,Q14807,Q06481,O94919,Q6YHK3,P07602,O15439,Q8NCG7,Q9NZJ7,P78310,O00459,Q9UEU0,Q8NBX0,Q8IWA4,Q96N67,P45973,P07355,P08195,Q9Y624,Q86Y91,P05556,O95140,P84095,P21333,Q9H0H5,Q9UBI6,P63096,Q07021,O75083,P27144	36
Citric acid cycle tca cycle	0.3162262398199158	0.4363909467360523	0.662553106334975	1.0	0.8493050790543885	19	P36957,P53597,P31040,P07954,P50213,P09622,O43837,Q99798,P23368,Q13423,Q9P2R7,P40926	12
Notch hlh transcription pathway	0.3715814506539729	0.435914091297041	0.6628990609208847	1.0	0.8493050790543885	4	Q04721,Q92769,Q13547	3
Export of viral ribonucleoproteins from nucleus	0.2815450137957047	0.4330648745638773	0.6649676400149906	1.0	0.8507605203590369	30	Q9NRG9,O15504,P49790,A8CG34,P12270,Q8NFH4,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	12
Viral messenger rna synthesis	0.2700902309570639	0.430746824349579	0.6666524681158141	1.0	0.8515207791579398	38	O15504,P49790,P52434,A8CG34,P12270,Q8NFH4,Q9BTX1,P24928,Q9UKX7,P62875	10
Apoptotic cleavage of cellular proteins	0.3212321545497982	0.4265472918374195	0.6697090953890132	1.0	0.8516952626142886	17	P02545,Q9UJU6,Q9UKV3,Q13813,Q07157,Q14126,P51572	7
Sensing of dna double strand breaks	0.3681586706153489	0.4225664506780821	0.6726116085854164	1.0	0.8546123967908819	4	O60934,P49959	2
Mitochondrial calcium ion transport	0.3194389227495183	0.4174616380392251	0.6763407782685711	1.0	0.8554598564465116	17	P35232,Q8NE86,Q10713,Q92667,O95202,Q9UJZ1,P21796,Q9Y277,Q96TA2,Q9H300	10
Golgi cisternae pericentriolar stack reorganization	0.3539599910936767	0.4159035617643048	0.6774805730984652	1.0	0.8554598564465116	11	Q9H8Y8,P62820	2
Assembly of the orc complex at the origin of replication	0.3766953571290573	0.4158172926939023	0.6775437039661829	1.0	0.8554598564465116	8	P62805,P16104,Q13416,Q9Y619	4
Transport of the slbp dependant mature mrna	0.2747332735389158	0.4049242445068499	0.6855331965932281	1.0	0.8611662160210437	32	Q9NRG9,O15504,Q96EE3,P49790,A8CG34,P12270,Q8NFH4,P35658,P52948,Q9BTX1,Q9UKX7,P37198,P49792	13
Crmps in sema3a signaling	0.3944883435392771	0.4039916923120698	0.6862188283019774	1.0	0.8611662160210437	6	Q9UIW2,O14786	2
Nef mediated cd8 down regulation	0.3912513413593889	0.3924663486292329	0.6947136708736159	1.0	0.8673888612422415	6	Q96CW1,O95782	2
Nef mediated cd4 down regulation	0.3912513413593889	0.3924663486292329	0.6947136708736159	1.0	0.8673888612422415	6	Q96CW1,O95782	2
Nephrin family interactions	0.3575262714072099	0.3841927165699385	0.7008356162003428	1.0	0.8721986444285754	9	O14936,O00459,Q13813	3
Hcmv early events	0.2533695362575108	0.3830627450472195	0.701673241776648	1.0	0.8721986444285754	46	Q9UER7,P63167,P83916,O15504,P62805,P49790,A8CG34,P12270,Q8NFH4,P05556,Q9BTX1,Q15022,Q9UKX7,P35658,Q9BVA1	15
Sensory processing of sound by outer hair cells of the cochlea	0.327135808255469	0.3810372692991844	0.7031755939682918	1.0	0.8729076338916725	14	O14936,O00159,Q9Y2J2,P26038,Q13813,Q01082,P23634	7
Pkmts methylate histone lysines	0.3115952534807519	0.3785855636318367	0.7049956441081391	1.0	0.874393890748964	17	P62805,O96028,Q9BZ95,Q6VMQ6,Q03164,Q9BYW2,Q15022	7
Thromboxane signalling through tp receptor	0.3561689524020665	0.3771369515443145	0.7060718318463732	1.0	0.8744686128185664	4	Q14344,Q9UBI6	2
Apoptotic execution phase	0.2742781969050599	0.3748370343944372	0.7077816695385679	1.0	0.874758331014216	28	P02545,P16403,Q9UKV3,Q07157,Q14126,P07305,P51572	7
Gluconeogenesis	0.2979087134653807	0.3598132854314819	0.7189867673707466	1.0	0.8823870079870547	20	Q9UBX3,P53007,Q16822	3
Keratinization	0.3578903041637818	0.3449925429632119	0.7300999768330887	1.0	0.8913568412814404	8	Q14126,Q02487,Q99959	3
Formation of the cornified envelope	0.3578903041637818	0.3449925429632119	0.7300999768330887	1.0	0.8913568412814404	8	Q14126,Q02487,Q99959	3
Resolution of d loop structures	0.3769073733215999	0.3430906688698713	0.7315302507355748	1.0	0.8915524930839818	6	Q9UQ84,O60934,P49959,P51530	4
Resolution of d loop structures through synthesis dependent strand annealing sdsa	0.3769073733215999	0.3430906688698713	0.7315302507355748	1.0	0.8915524930839818	6	Q9UQ84,O60934,P49959,P51530	4
Eph ephrin mediated repulsion of cells	0.3117792985053881	0.3143194507827394	0.7532784267083472	1.0	0.9091988674661544	14	O95782,P07947,Q15375,P29317,Q96CW1,P49768,P53680	7
Methionine salvage pathway	0.297197792314239	0.3123507566934131	0.7547739699036939	1.0	0.9096160117980998	3	Q9BV57	1
Cell junction organization	0.2910992272297411	0.3101002170377895	0.7564847472219751	1.0	0.9108958705828928	19	Q92692,Q13418,Q9Y624,P05556,P14923	5
Calnexin calreticulin cycle	0.3252096691847184	0.3001899396161701	0.7640322784401314	1.0	0.9168387341281576	11	P27824,Q13438,P14314,Q9NYU1,Q9GZP9	5
Caspase mediated cleavage of cytoskeletal proteins	0.3617945736233451	0.2943067830007936	0.7685234899783526	1.0	0.9189974167944306	6	Q9UJU6,Q13813	2
Er quality control compartment erqc	0.3607985270643082	0.2912162538626383	0.7708859322587873	1.0	0.9189974167944306	6	Q13438,Q9GZP9,Q9NYU1	3
Long term potentiation	0.3676654598234893	0.2875570061470757	0.7736858594380462	1.0	0.9189974167944306	5	Q12959	1
Unblocking of nmda receptors glutamate binding and activation	0.3676654598234893	0.2875570061470757	0.7736858594380462	1.0	0.9189974167944306	5	Q12959	1
Ras activation upon ca2 influx through nmda receptor	0.3676654598234893	0.2875570061470757	0.7736858594380462	1.0	0.9189974167944306	5	Q12959	1
Negative regulation of nmda receptor mediated neuronal transmission	0.3676654598234893	0.2875570061470757	0.7736858594380462	1.0	0.9189974167944306	5	Q12959	1
E3 ubiquitin ligases ubiquitinate target proteins	0.2864244958897436	0.2756899068476236	0.7827862484906247	1.0	0.927453074161044	18	Q9BUN8,O75381,P49459,Q14527	4
Synthesis of substrates in n glycan biosythesis	0.307308865670487	0.2737084011770326	0.7843087210223896	1.0	0.9280750998680402	13	P10619	1
Regulation of tp53 activity	0.2342485551488512	0.2693191049793226	0.7876841314986949	1.0	0.9308994281348212	50	Q9UER7,O60934,P49959,Q9Y5B9,Q92804,P40938,P55201,Q9Y3T9,Q9ULW0,Q86YP4,O94776,P67870,Q12962,P42771,O95696,Q13625,Q14839,Q09028	18
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1	0.3237217598097398	0.2659646065033836	0.7902664674694013	1.0	0.9317950502010308	4	Q5TKA1,Q13547,Q09028	3
Oxidative stress induced senescence	0.2936905554441396	0.2648805095915869	0.7911015133036878	1.0	0.9317950502010308	15	P16104,P62805,Q9HC52,P42771,Q8IXK0,Q15022,Q09028	7
Chromatin modifying enzymes	0.2220602886618776	0.2645308529117442	0.7913708940660182	1.0	0.9317950502010308	77	O60341,Q8NB78,Q96L91,P51532,Q9BZ95,Q14839,O96028,O95251,Q68CP9,Q8IYH5,Q8TAQ2,Q12962,P55201,Q6VMQ6,Q86U86,Q96GM5,O95696,Q03164,Q9H0E3,Q86YP4,O94776,Q96ES7,Q15022	23
Death receptor signalling	0.2548240576750279	0.2640254293664819	0.7917603239956053	1.0	0.9317950502010308	28	P49768,P78536	2
Cell extracellular matrix interactions	0.3425582129867038	0.2620470932748925	0.793285135184453	1.0	0.9318059126315464	7	P05556,Q13418	2
Ion channel transport	0.258693085294196	0.2596843391312758	0.7951072738792981	1.0	0.9318274597039456	26	P27105,Q96PU5,Q9HD20,Q9C0H2	4
Pi metabolism	0.272474182630166	0.2404133496874087	0.8100098300941869	1.0	0.9418267589301176	20	Q10713	1
Glutamate and glutamine metabolism	0.3345650425003788	0.23824857569155	0.8116883036363549	1.0	0.9418267589301176	7	P32322,P00367	2
Rnd3 gtpase cycle	0.2733374155633691	0.2319823427250523	0.8165517282046362	1.0	0.9449761259359544	19	Q14160,Q14254,Q9Y2I1,Q07065,Q9Y2U8,Q03001,O00459,Q86UP2	8
Energy dependent regulation of mtor by lkb1 ampk	0.3221125829072469	0.2271140252793095	0.8203350783962788	1.0	0.9469199028931392	8	Q15382,Q9Y2Q5,Q9Y376,Q8N122	4
Mitochondrial fatty acid beta oxidation of saturated fatty acids	0.3205808141821002	0.2226213600482693	0.8238302106911688	1.0	0.9485071871593408	8	P55084,P40939,Q16836,P16219	4
Interactions of rev with host cellular proteins	0.2402579132539925	0.2211336970262258	0.8249883332242169	1.0	0.948635233289763	35	P06748,Q9UKX7,O15504,P49790,Q8NFH5,A8CG34,Q8NFH4,Q9BTX1,P57740,Q9NRG9,Q5SRE5,P52948,P49792,P37198,P18754,Q96EE3,P12270,Q9BW27,P35658	19
Endosomal vacuolar pathway	0.3066119141077531	0.2152686243527487	0.8295578903085172	1.0	0.9521121162088872	4	Q9UIQ6	1
Rhob gtpase cycle	0.2473197321840625	0.2146419813733705	0.8300464602846709	1.0	0.9521121162088872	27	P27105,O75955,P43121,Q86VI3,O00459,Q9H0H5	6
Trna modification in the nucleus and cytosol	0.2976288309943858	0.2057322636290667	0.8370000548886569	1.0	0.958287458560471	11	Q5VV42,Q9Y606,Q9NX74,O75648	4
N glycan trimming in the er and calnexin calreticulin cycle	0.2687657873324775	0.2039503328420691	0.8383923116920564	1.0	0.9585527733026444	18	P27824,Q9BUN8,P14314,Q9NYU1,Q9GZP9,Q14165,Q13724	7
Interleukin 27 signaling	0.2601127186457276	0.1877585317802539	0.8510659443933759	1.0	0.9671721582397608	3	P27824	1
Interleukin 35 signalling	0.2601127186457276	0.1877585317802539	0.8510659443933759	1.0	0.9671721582397608	3	P27824	1
Rhoq gtpase cycle	0.2560670983628252	0.1855216579631892	0.8528198945162562	1.0	0.9671721582397608	21	P27105,P63167,Q14160,O96013,Q86VI3,Q15758,P14923	7
Apoptosis induced dna fragmentation	0.2979228026694226	0.1830612731378534	0.8547499418007005	1.0	0.9679935447201966	9	P26583,P16403,P07305	3
Atf4 activates genes in response to endoplasmic reticulum stress	0.2809988797646411	0.1828406225240617	0.8549230736845042	1.0	0.9679935447201966	13	Q9NQT5,Q13868	2
Interaction between l1 and ankyrins	0.2937329264884084	0.181106546283967	0.8562839463756908	1.0	0.9681032832476704	4	Q13813	1
Met promotes cell motility	0.305341005165644	0.1806091789777352	0.8566743505918339	1.0	0.9681032832476704	8	Q96N67,P07942	2
Deposition of new cenpa containing nucleosomes at the centromere	0.3009710110788612	0.169483578417821	0.8654162880313203	1.0	0.971505444447162	8	P62805,Q96T23,P16104,Q09028	4
Netrin 1 signaling	0.2863597324325297	0.1618918164933745	0.8713910473007038	1.0	0.971505444447162	10	O94813	1
Srp dependent cotranslational protein targeting to membrane	0.2134860654514292	0.1593425085663235	0.8733990315709961	1.0	0.971505444447162	92	P84098,P46782,P61009,P26373,P46779,Q02878,P62847,Q15629,P67812,P04843,Q07020,P61513,P08240,P39023,P62910,P62424,Q9Y3U8,Q02543,P62913,P62273,P50914,P62266,P62917,P36578,P61927,P61313,P46776,Q15005,P61353,P40429,P42766,P60059	32
Activation of anterior hox genes in hindbrain development during early embryogenesis	0.2567355085588988	0.1548228509854757	0.8769609759427299	1.0	0.9725538785336436	17	P62805,P16104,P52434,P24928,Q15022,P62875,Q09028	7
Signaling by retinoic acid	0.2701580136961437	0.1509739551244202	0.8799962611764098	1.0	0.9751497637661244	13	P11177,O00330,Q15120,P09622,P50416	5
Collagen biosynthesis and modifying enzymes	0.2746620738265809	0.1413916808710031	0.8875605259522867	1.0	0.979665863551109	11	P50454,Q8NBJ5,Q32P28,P13674,P07237,O75718	6
Striated muscle contraction	0.3065715135295921	0.1371849001012003	0.8908846460366009	1.0	0.9801901847716435	5	P11532,P06753,P08670,Q9NYL9	4
Mitochondrial trna aminoacylation	0.2523098962430259	0.1363732015513191	0.891526257801559	1.0	0.9801901847716435	16	Q9BW92,Q5JTZ9,Q5JPH6	3
Ncam signaling for neurite out growth	0.2879740537788808	0.124494441723176	0.9009238010072962	1.0	0.988200794229878	7	P13591,Q13813	2
Rhog gtpase cycle	0.214317977175495	0.1193898810837928	0.9049664776810484	1.0	0.9910865324993696	41	Q14739,P43121,P42167,O96013,P84095,Q9Y2U8,Q14126	7
The role of nef in hiv 1 replication and disease pathogenesis	0.2607270560190707	0.1167228706940207	0.9070796659649318	1.0	0.9919422288196174	12	P63000,O43747,O95782,Q9UI12,P04439,Q9BXS5,Q96CW1,O94973,Q10567,P53680,Q13177	11
Conversion from apc c cdc20 to apc c cdh1 in late anaphase	0.267886081181395	0.1116805813974926	0.9110766767945015	1.0	0.9931301663194722	9	Q96DE5	1
Rho gtpases activate paks	0.2519047466801814	0.1050454177968949	0.9163397698608724	1.0	0.99372366479714	13	P35240,P21333	2
Hdr through mmej alt nhej	0.2705357142857163	0.1037321606858715	0.9173819037862272	1.0	0.99372366479714	8	O60934,P49959,P18887,P09874,Q92878,P39748,P49916	7
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.2605717689100605	0.1025685961387848	0.918305368000814	1.0	0.99372366479714	10	O43747,O95782,Q9UI12,P04439,Q9BXS5,Q96CW1,O94973,Q10567,P53680	9
Regulation of lipid metabolism by pparalpha	0.2306197620459291	0.0944436231211005	0.9247567644034524	1.0	0.99372366479714	20	P37268,P50416,P04035	3
Dag and ip3 signaling	0.2645833333333355	0.0932752567784035	0.9256848886011192	1.0	0.99372366479714	8	Q13555,P17252,P17612,P10644,P13861,P52292,O43865	7
Circadian clock	0.252412454566263	0.0872706490233315	0.9304563836725586	1.0	0.99372366479714	10	Q9BWF3,P50416	2
Wnt5a dependent internalization of fzd4	0.260416666666669	0.086414489295622	0.9311369292237376	1.0	0.99372366479714	8	O95782,P17252,P09496,Q96CW1,Q00610,O94973,P53680	7
Retrograde neurotrophin signalling	0.2604166666666689	0.086414489295622	0.9311369292237376	1.0	0.99372366479714	8	O95782,P50570,P09496,Q96CW1,Q00610,O94973,P53680	7
Heme biosynthesis	0.2707329297127767	0.0856641676017193	0.9317333874936312	1.0	0.99372366479714	6	P08397,Q7KZN9,P50336	3
Cardiac conduction	0.248358564790337	0.084702967080492	0.9324975370582352	1.0	0.99372366479714	11	P05023,P16615,Q13555,Q12797,P23634,O43865	6
Ion homeostasis	0.248358564790337	0.084702967080492	0.9324975370582352	1.0	0.99372366479714	11	P05023,P16615,Q13555,Q12797,P23634,O43865	6
Kinesins	0.2295651787215185	0.0837822682409822	0.9332295463392186	1.0	0.99372366479714	18	Q9H0H5,Q86Y91	2
Transcriptional activation of mitochondrial biogenesis	0.2443230057653896	0.0825707177721923	0.9341928855750824	1.0	0.99372366479714	12	Q15648,P04179,Q00059,Q8WVM0,Q96RR1,P00367,P51610	7
Trafficking of glur2 containing ampa receptors	0.2603391847664471	0.0780239343815937	0.937809014142598	1.0	0.99372366479714	7	P46459,O95782,P17252,Q96CW1,O94973,P53680	6
Wnt5a dependent internalization of fzd2 fzd5 and ror2	0.2603391847664454	0.0780239343815911	0.9378090141426	1.0	0.99372366479714	7	O95782,P09496,Q96CW1,Q00610,O94973,P53680	6
Vldlr internalisation and degradation	0.2603391847664454	0.0780239343815911	0.9378090141426	1.0	0.99372366479714	7	O95782,P09496,Q96CW1,Q00610,O94973,P53680	6
Perk regulates gene expression	0.2287503728004714	0.0715870560962834	0.9429305413837176	1.0	0.9946638079888436	15	Q92945,Q96B26,P25208,Q9NQT5,Q13868,Q9Y3B2,Q9NQT4,P08243,P20042,Q15024,O95453,P05198,Q5RKV6,Q9Y2L1	14
Rhou gtpase cycle	0.2228955875492326	0.0715664286817109	0.9429469575734692	1.0	0.9946638079888436	19	O96013,Q13813,Q01082,Q03001,P29317,O00459,P60953	7
Gap junction degradation	0.2613737734166004	0.0686078244510153	0.9453017905339244	1.0	0.9957587140574152	5	Q9UM54,P50570,P09496,Q96CW1	4
Signal transduction by l1	0.2313098294213134	0.0606389551157727	0.9516467488961686	1.0	1.0	12	P13591,O14786,P67870	3
Apc c cdc20 mediated degradation of cyclin b	0.2334458184780472	0.0604862702715144	0.9517683505642134	1.0	1.0	11	Q96DE5	1
Translation of sars cov 2 structural proteins	0.2149409850915788	0.0532192883104805	0.9575571875428188	1.0	1.0	18	P04843,P27824,P14314,Q10472,P48729,Q9H0U3,Q16706,Q13724	8
Beta oxidation of octanoyl coa to hexanoyl coa	0.2427429548051423	0.0503262296808291	0.9598624219862436	1.0	1.0	5	Q16836,P40939	2
Ca2 pathway	0.2379535990481759	0.0482390608906184	0.9615257203191014	1.0	1.0	6	P35222,P17252,P09471,Q9UBI6,Q9HCE1	5
Peroxisomal lipid metabolism	0.2228379166557365	0.0465229443187338	0.9628934469613404	1.0	1.0	11	O75521,O43808,Q5T8D3,O15254	4
Factors involved in megakaryocyte development and platelet production	0.1904011999663774	0.0415973401854055	0.9668196936328536	1.0	1.0	47	Q96N67,O60341,P45973,P27144,Q92667,Q14807,Q86Y91,O95140,Q9H0H5,Q8IWA4	10
Beta oxidation of decanoyl coa to octanoyl coa coa	0.2273769972019347	0.0398551111439895	0.9682086387632252	1.0	1.0	6	Q16836,P40939	2
Rhov gtpase cycle	0.2070313472390256	0.0392353667712034	0.9687027367293282	1.0	1.0	17	Q96KM6	1
Signaling by cytosolic fgfr1 fusion mutants	0.2155782108994575	0.0346524401056772	0.972356885426205	1.0	1.0	8	P11274,O15164	2
Tysnd1 cleaves peroxisomal proteins	0.2179601546238573	0.0335766316582172	0.973214756994066	1.0	1.0	5	P51659,P22307,O00116,Q15067	4
Butyrate response factor 1 brf1 binds and destabilizes mrna	0.2084644498317759	0.0313041357887706	0.9750269921434644	1.0	1.0	10	Q9NQT5	1
Homologous dna pairing and strand exchange	0.2067938021454118	0.0306730964127258	0.9755302470161036	1.0	1.0	12	O60934,P40937,P49959,P40938,Q92878,P15927,P27694,Q9UQ84,P54132,P51530,P35249	11
Hdr through single strand annealing ssa	0.2067938021454118	0.0306730964127258	0.9755302470161036	1.0	1.0	12	O60934,P40937,P49959,P40938,Q92878,P15927,P27694,Q9UQ84,P54132,P51530,P35249	11
Signaling by nuclear receptors	0.1886442522532535	0.0278315538323705	0.9777964993858608	1.0	1.0	60	O60341,Q8NB78,O00330,Q9UQE7,P50416,Q15648,P11177,P52434,P09622,O00459,O14646,O00767,Q9UBI6,P24928,P62875,P63096,P62805,Q15120,Q8WVM7,Q14683	20
Apc cdc20 mediated degradation of nek2a	0.2021113194648073	0.026241351744675	0.9790648333049968	1.0	1.0	11	Q96DE5	1
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components	0.2021113194648073	0.026241351744675	0.9790648333049968	1.0	1.0	11	Q96DE5	1
Rho gtpase cycle	0.1926190214906802	0.0256910838738827	0.9795037355492238	1.0	1.0	166	P27105,P43121,Q8IYB3,Q5T8D3,Q96HY6,Q96T58,Q96KM6,Q14126,Q15058,P51572,O75955,O96013,Q07065,Q9UQB8,O00459,P42167,P50402,P30519,Q9Y2U8,Q86VI3,Q9BX68,P84095,Q9UIW2,Q9H0H5,Q14739,Q9Y2I1,Q07021	27
Ksrp khsrp binds and destabilizes mrna	0.1937755187354374	0.0200003424961133	0.984043099348485	1.0	1.0	12	Q9NQT5	1
Response of eif2ak4 gcn2 to amino acid deficiency	0.1824089732615047	0.0194349146027953	0.9844941578379208	1.0	1.0	75	P84098,P46782,P26373,P46779,Q02878,P62847,Q07020,P61513,P39023,P62910,Q9Y3U8,P62424,Q02543,P62913,P62273,P50914,P62266,P62917,P36578,P61927,P61313,P46776,P61353,P08243,P40429,P42766	26
Opioid signalling	0.1910509625782094	0.0182161790205002	0.9854663957861568	1.0	1.0	19	Q9UBI6,P63096	2
Estrogen dependent gene expression	0.1850985015214442	0.0167490352541755	0.986636828160776	1.0	1.0	31	Q15648,O60341,O14646,P16104,P62805,Q14683,Q8WVM7,P52434,P17844,O60216,Q9UQE7,P24928,P62875	13
Fgfr1 mutant receptor activation	0.178234153100668	0.013664838879609	0.9890973753370492	1.0	1.0	10	P11274,O15164	2
Interferon gamma signaling	0.1813005410673547	0.0117737291242594	0.9906061403397428	1.0	1.0	13	P13591,P04439,P29372,Q12899	4
Phosphorylation of the apc c	0.1727733095025387	0.0101920652735176	0.9918680492645358	1.0	1.0	11	Q9UJX4,P14635,P06493,Q9UJX3,Q9UJX2,Q96DE5,P30260,Q16763,P53350,Q13042	10
Rmts methylate histone arginines	0.1821055000767734	0.0081019850697746	0.9935356219236744	1.0	1.0	21	P16104,P62805,P51532,Q68CP9,Q86U86,Q8TAQ2,Q96GM5	7
Diseases of mitotic cell cycle	0.1729278473464547	0.0067183605434722	0.9946395641735876	1.0	1.0	14	Q9UER7,Q9UJX4,Q9UJX3,P46100,P11802,Q9UJX2,Q96DE5,P24941,Q13309,P30260,P06400,Q16763,Q13042	13
Formation of the beta catenin tcf transactivating complex	0.154560316776644	0.0053973020236667	0.995693596953547	1.0	1.0	11	P51532,P62805	2
Trna processing	0.1806742921450337	0.0051053066598439	0.99592657233303	1.0	1.0	59	O15504,O75648,P49790,O94992,A8CG34,P12270,Q9BVC5,Q8NFH4,Q5VV42,Q99714,Q969Y2,Q9NX74,Q7L0Y3	13