Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Neutrophil degranulation 0.5974721463055785 4.36075011889111 1.296173231657427e-05 0.0174608693317248 0.0176149942182257 166 O00584,P07602,P06280,P10619,P15586,Q9BTY2,P11717,P17900,P10253,P13473,P42785,Q92820,P27105,P04066,P11279,P08236,P53634,Q92542,Q9H7Z7,P01889,P16278,O15260,P07686,P10321 24 Metabolism of lipids 0.591736693642256 4.161419553498583 3.162754137497892e-05 0.042071854429264 0.0214909143642988 157 Q9UMR5,Q9BUT1,P07602,P06280,Q99538,P10619,Q96N66,P35790,Q15392,P48651,Q15125,P06865,Q8IV08,P34913,P17900,P50897,Q16850,P35610,Q8NCC3,P23786,O43772,Q14739,Q15165,Q10713,Q9H7Z7,P16278,Q9UBM7,P51648,P07686,Q96G23,O95487,P04062 32 Sphingolipid metabolism 0.844707489276873 3.2533914912408024 0.0011403626858685 0.787887228061332 0.2896094591697261 24 P51648,P17900,P07686,Q06136,Q96G23,P07602,P06280,P10619,P04062,P16278,Q13510,P06865 12 Innate immune system 0.5249868507404549 2.966036501344282 0.0030166468422723 0.9835234822773944 0.2896094591697261 260 P05067,O00584,P07602,P06280,P04439,Q99538,P10619,P15586,Q9BTY2,P11717,P28072,P60900,Q8IV08,P17900,P10253,P13473,P42785,Q92820,P27105,P04066,P11279,P08236,P53634,Q92542,Q9H7Z7,Q9UQB8,P01889,P16278,O15260,P07686,P49721,P10321 32 Glycosphingolipid metabolism 0.8973587025199803 2.904605676626638 0.0036771604622638 0.993305516965203 0.2896094591697261 14 P17900,P07686,P07602,P06280,P10619,P16278,P06865 7 Glycosaminoglycan metabolism 0.8953318137940698 2.7454205431882626 0.0060433399768189 0.9997355388340649 0.2896094591697261 13 P07686,Q96L58,O43505,P54802,P16278,P15586,Q7LGA3,P06865,P08236 9 Response to elevated platelet cytosolic ca2 0.7224314600840367 2.725989617220418 0.0064109014959994 0.9998400200857616 0.2896094591697261 31 P05067,P13473,P07602,Q8NBX0,O43852,Q9UEU0,Q08380 7 Ion channel transport 0.7303526031497984 2.6169107537947776 0.0088729536959177 0.9999945076767108 0.2896094591697261 23 P51790,Q15904,Q9C0H2,Q9Y487,P27105,Q93050 6 Trans golgi network vesicle budding 0.6924480525631863 2.5460135627413933 0.0108960954783623 0.9999996582061884 0.2945079075066075 31 P05067,Q99523,P02786,P15586,P11717 5 Rhoj gtpase cycle 0.763944993988488 2.487979563455796 0.0128471115236907 0.999999976642431 0.2945079075066075 18 P27105,P02786 2 Golgi associated vesicle biogenesis 0.6849295894674872 2.3881902894973788 0.0169315724912502 0.9999999999165716 0.3486364699334703 25 P11717,Q99523,P02786 3 Plasma lipoprotein assembly remodeling and clearance 0.7831624920899697 2.380402541184814 0.0172937349298814 0.999999999949436 0.3507788920852063 14 P35610,P01130,Q8WTV0,O15118 4 Extracellular matrix organization 0.6770678619441896 2.374660928511557 0.0175650774314823 0.999999999965258 0.3510432386674201 27 P35613,Q9Y624,P05067,Q08722,Q32P28,Q92542,P05556,P13674,O14936,P55081 10 Cdc42 gtpase cycle 0.6789031022990107 2.3687428322470656 0.0178486592239659 0.9999999999765328 0.3515409838459379 26 P27105,Q8TAA9,P02786,Q14739 4 Diseases of carbohydrate metabolism 0.8823855167372837 2.363217449534595 0.0181170358394924 0.999999999983813 0.35172931008386 9 P54802,P10253,P08236,P15586 4 Rhoq gtpase cycle 0.7251725800615056 2.2871109632880966 0.0221893471357284 0.9999999999999428 0.3722879352772209 18 P27105,P02786 2 Gpcr ligand binding 0.8935831658513924 2.2471661353166192 0.0246294115583529 0.999999999999998 0.3881002534098953 8 P07602,P05067,P42892 3 Transferrin endocytosis and recycling 0.8206073119278574 2.233429582101875 0.0255206292078831 0.9999999999999994 0.3881002534098953 11 Q93050,P02786,Q15904 3 Keratan sulfate keratin metabolism 0.964822279223162 2.207448868538461 0.0272827154668586 1.0 0.3881002534098953 5 P06865,P15586,P16278,O43505 4 Cargo trafficking to the periciliary membrane 0.6771467453697944 2.196528218635027 0.0280541576759536 1.0 0.3881002534098953 20 O43924,A6NIH7 2 Plasma lipoprotein clearance 0.7990315285881424 2.196306498269425 0.0280700129314499 1.0 0.3881002534098953 12 P35610,P01130,Q8WTV0,O15118 4 Antigen presentation folding assembly and peptide loading of class i mhc 0.7680301436318744 2.1754949648624766 0.0295930450270047 1.0 0.3881002534098953 13 P10321,P01889,O95487 3 Peptide ligand binding receptors 0.9105853587710055 2.1634780531742193 0.03050442995128 1.0 0.3881002534098953 7 P07602,P05067,P42892 3 Class a 1 rhodopsin like receptors 0.9105853587710055 2.1634780531742193 0.03050442995128 1.0 0.3881002534098953 7 P07602,P05067,P42892 3 Stimuli sensing channels 0.9094563171812884 2.1592892136560837 0.0308277364339688 1.0 0.3881002534098953 7 Q9C0H2,P27105 2 Slc mediated transmembrane transport 0.7008988365593056 2.15895608782536 0.0308535738491562 1.0 0.3881002534098953 18 P35613,P11166,O00400,Q99808,P08195,P30825 6 Mitochondrial protein import 0.6330152848588491 2.152387694403816 0.0313668320845055 1.0 0.3881002534098953 33 Q99595,Q10713,O60830,Q9NS69,P62072,Q5JRX3 6 Rac3 gtpase cycle 0.6369135066483688 2.1481840446908493 0.0316991376957309 1.0 0.3881002534098953 28 Q14739,Q8TAA9,Q9UQB8,P02786,Q14126 5 Diseases of metabolism 0.6387954456671647 2.1210574417034795 0.0339169687940306 1.0 0.3900462778118527 39 Q8NCH0,P10253,P07686,Q96EY8,Q96L58,O75874,P10619,P54802,O43505,P48507,P16278,P15586,P06865,P08236 14 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.936606815683405 2.1061974717256224 0.0351872026928239 1.0 0.3900462778118527 5 Q5KU26,P04439,P01889,P10321 4 Heparan sulfate heparin hs gag metabolism 0.9340417735434284 2.096938841431504 0.035998989613224 1.0 0.3900462778118527 5 P54802,Q96L58,P16278,P08236 4 Rhob gtpase cycle 0.6735659030606019 2.09125422005536 0.0365052812542137 1.0 0.3900462778118527 19 P27105,P02786 2 Amyloid fiber formation 0.9011275419865246 2.0793389872921075 0.0375862040729404 1.0 0.3900462778118527 6 P05067 1 Diseases of glycosylation 0.7145828639175603 2.0792269753627313 0.0375964933796126 1.0 0.3900462778118527 15 P07686,Q96L58,O43505,P10619,P16278,P06865 6 Ras processing 0.9259704828216062 2.0677471760531416 0.0386638032539079 1.0 0.3900462778118527 5 O43924 1 Ldl clearance 0.7867864389549115 2.0384435293678047 0.0415055967954722 1.0 0.3900462778118527 10 P35610,P01130,O15118 3 Cholesterol biosynthesis 0.7026100205922591 2.0190952261985395 0.0434773229474039 1.0 0.3900462778118527 15 Q9UBM7,Q14739,Q16850,Q15392,Q15125 5 Mucopolysaccharidoses 0.9699633699633702 2.014326284745236 0.0439752880800949 1.0 0.3900462778118527 4 P54802,P15586,P08236 3 Keratan sulfate degradation 0.9644688644688646 1.994877427389943 0.046056249979439 1.0 0.3900462778118527 4 P06865,P16278,P15586 3 Rhoh gtpase cycle 0.6413307576922775 1.9935296725261695 0.0462034776836381 1.0 0.3900462778118527 20 P27105,P02786 2 G alpha i signalling events 0.6519980009470672 1.971679470221928 0.0486462087011301 1.0 0.3900462778118527 19 P05067 1 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.6984306725339173 1.9691346294700416 0.0489376331548321 1.0 0.3900462778118527 14 Q9BTY2,P05067,O43852 3 Rhoc gtpase cycle 0.60386099524133 1.957664230738002 0.0502694250575246 1.0 0.3900462778118527 29 Q14739,Q07021,Q13190,Q8TAA9,O75955,P52565,P02786,P27105 8 Sphingolipid de novo biosynthesis 0.7660766769760202 1.949481882171738 0.0512379044064221 1.0 0.3900462778118527 10 Q96G23,P51648,O15269,Q06136 4 Endosomal vacuolar pathway 0.9501831501831502 1.9441509843573748 0.0518772465756351 1.0 0.3900462778118527 4 P10321,P01889,Q9UIQ6 3 Integrin cell surface interactions 0.9362637362637364 1.8945090551999175 0.0581574735835661 1.0 0.4240710501199889 4 P35613,Q9Y624,Q08722 3 Binding and uptake of ligands by scavenger receptors 0.8385206121794837 1.8921882669131955 0.0584659010926182 1.0 0.4240710501199889 7 Q5KU26 1 Insulin receptor recycling 0.7521913609064375 1.8893612674265257 0.0588434371464097 1.0 0.4240710501199889 10 Q93050,Q15904 2 Cell surface interactions at the vascular wall 0.741674600534757 1.888366476621798 0.0589767685597335 1.0 0.4240710501199889 11 P35613,Q9Y624,Q08722,P08195,Q92896 5 Transport of vitamins nucleosides and related molecules 0.7997643418456277 1.8780327030949515 0.0603766914324492 1.0 0.4295912233335004 8 O00400 1 Hyaluronan uptake and degradation 0.9290177785381036 1.868585216518776 0.0616805441169678 1.0 0.4343205153106702 4 P06865,P08236 2 Hyaluronan metabolism 0.9290177785381036 1.868585216518776 0.0616805441169678 1.0 0.4343205153106702 4 P06865,P08236 2 Metabolism of steroids 0.6070373395087746 1.8633566473033671 0.0624121051570423 1.0 0.437206447981549 44 Q9UBM7,Q14739,Q16850,Q99538,O95487,O95772,Q15392,P04062,Q15125,Q86X55,P37268 11 Chondroitin sulfate dermatan sulfate metabolism 0.917948717948718 1.828878413428654 0.0674178247100911 1.0 0.4635321360083018 4 Q96L58,P07686,P06865 3 Diseases associated with glycosaminoglycan metabolism 0.917948717948718 1.828878413428654 0.0674178247100911 1.0 0.4635321360083018 4 Q96L58,P07686,P06865 3 Adaptive immune system 0.4043427674114872 1.7958156570817558 0.0725238397870511 1.0 0.4952758707065451 170 P53634,Q8NEZ5,Q9UIQ6,Q5KU26,P04439,Q99538,Q9UBG0,P10619,P49721,O95487,P10321,P01889,P62942,P05556,P28072,P60900 16 E2f mediated regulation of dna replication 0.7401191367927764 1.7752520268875325 0.0758562826909092 1.0 0.507371099957275 9 Q14181,Q9Y619 2 Basigin interactions 0.8411986645953815 1.7560807833567558 0.0790746158449318 1.0 0.5242068435768894 5 P35613,P08195 2 Regulation of mecp2 expression and activity 0.7976070890987156 1.7347785361103836 0.0827800393710374 1.0 0.5357051119297134 7 Q14739 1 Signaling by tgfb family members 0.6292291787789877 1.7017888347745893 0.0887949602734159 1.0 0.5638894907082815 17 Q9Y624,Q9Y4E8,P62942 3 Signaling by tgf beta receptor complex 0.6320890769564393 1.684825146728524 0.0920223117221943 1.0 0.5738848534361092 16 Q9Y624,Q9Y4E8,P62942 3 Rac1 gtpase cycle 0.5628010914712697 1.6817882696482416 0.0926099041779786 1.0 0.5738848534361092 34 Q14739,Q68EM7,Q8TAA9,P05556,Q9UQB8,P02786 6 Signaling by insulin receptor 0.6365977627197983 1.6572054183978315 0.0974779514568449 1.0 0.5759675479558792 14 Q93050,Q15904 2 Rac2 gtpase cycle 0.5528646926468315 1.6426322117533063 0.1004590519356571 1.0 0.590554837726265 30 Q14739,Q86XL3,Q8TAA9,P02786,Q14126 5 Antigen processing cross presentation 0.5755334888603478 1.6051590904813664 0.1084587978979718 1.0 0.5931499199413204 49 Q9UIQ6,P04439,P49721,Q9UBG0,P10321,P01889,P28072 7 Transport of small molecules 0.4829328123138275 1.5910537221714482 0.1115974861000599 1.0 0.600519590055898 134 Q99808,Q9C0H2,P02786,Q8WWC4,Q9Y487,P28072,P60900,P35613,P11166,P35610,P08183,Q9UJZ1,P27105,P51790,Q9HD20,P01130,Q15904,O00400,P10644,Q10713,P20618,O15118,P63208,P38571,Q93050,Q8WTV0,P49721,P08195,P30825 29 Phase i functionalization of compounds 0.6183928033665178 1.5636510554816114 0.1178995378556853 1.0 0.6218598975331359 14 Q16850,O43169,P05091,P07099 4 Lysosome vesicle biogenesis 0.6298000837555269 1.5128567030021534 0.1303160618830414 1.0 0.6590935761121292 13 P05067 1 Cs ds degradation 0.9637628111273806 1.510438382895097 0.1309316008302143 1.0 0.6590935761121292 2 P06865 1 Rnd1 gtpase cycle 0.6423392314796477 1.477354412389009 0.1395806594391144 1.0 0.6824920658155449 12 O75976,P51648,P02786,Q8TAA9 4 Hdms demethylate histones 0.7265682084837646 1.4565073089309564 0.1452524306179512 1.0 0.6950635676401258 7 Q8NB78,Q9UPP1,Q8IUF8 3 Signaling by erbb4 0.7303982287052058 1.4300603657199102 0.1526996943102545 1.0 0.7201513870038737 6 Q96J02,Q92542 2 Transcriptional regulation by e2f6 0.8056451617282555 1.4201935502075298 0.1555513408609496 1.0 0.7214821577816745 4 Q13185,Q15022 2 Pink1 prkn mediated mitophagy 0.6545362624306895 1.4045376102559233 0.1601588202404922 1.0 0.733196897530691 9 Q9NS69,Q8N4H5 2 Ecm proteoglycans 0.9355783308931224 1.402471163774501 0.1607745956321855 1.0 0.733196897530691 2 P05067 1 Elastic fibre formation 0.9355783308931188 1.402471163774487 0.1607745956321897 1.0 0.733196897530691 2 P55081 1 Molecules associated with elastic fibres 0.9355783308931188 1.402471163774487 0.1607745956321897 1.0 0.733196897530691 2 P55081 1 Hs gag degradation 0.9696082021237642 1.3893960650995116 0.1647123461803554 1.0 0.7378781018930063 3 P54802,P08236 2 Carnitine metabolism 0.7429556541191679 1.385435099414608 0.1659194646728889 1.0 0.7378781018930063 5 P23786 1 Death receptor signalling 0.5255313505728603 1.381411349271947 0.1671525182724749 1.0 0.738364518356951 21 Q9NQC3,Q92542,Q14344,P52565,Q13501,Q8TCT8 6 Apoptotic cleavage of cell adhesion proteins 0.7171621347595997 1.37847873413594 0.1680555291995 1.0 0.7391180070618789 6 Q14126 1 Dap12 interactions 0.7388616172161611 1.3698496012375498 0.1707338548669716 1.0 0.7433586584309138 5 P01889 1 Diseases of programmed cell death 0.5220224120529735 1.3648453055262155 0.1723016757952449 1.0 0.7433586584309138 22 P05067,Q15022,Q14181,P04632 4 Signalling to ras 0.78937728937729 1.3604205633906896 0.1736968748428422 1.0 0.7446500091842985 4 P11233,P62993,Q16539 3 Interferon alpha beta signaling 0.6437766920155391 1.3572684612949588 0.1746959246502277 1.0 0.746577866665596 9 P10321,P01889 2 Nrif signals cell death from the nucleus 0.922035139092243 1.3506814713774955 0.1767974901182858 1.0 0.7508368408460951 2 Q92542 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.7839235488713105 1.3403722680667287 0.1801243470011728 1.0 0.750886464952742 4 P67812 1 Incretin synthesis secretion and inactivation 0.7839235488713105 1.3403722680667287 0.1801243470011728 1.0 0.750886464952742 4 P67812 1 Signaling by notch1 0.7067344249227798 1.3377771137136716 0.1809691045238834 1.0 0.751431895664938 6 P63208,Q92542 2 Cell death signalling via nrage nrif and nade 0.6279412960406892 1.3365760955207655 0.1813610461943338 1.0 0.751431895664938 10 Q13501,Q92542 2 Rhog gtpase cycle 0.5040896267601808 1.3287449608322237 0.1839321260900737 1.0 0.7568153455261143 31 Q14739,Q86XL3,Q8TAA9,P02786,Q14126 5 Fatty acyl coa biosynthesis 0.591672924408599 1.3234237821201698 0.1856944872944521 1.0 0.7568153455261143 13 Q9UMR5 1 Sialic acid metabolism 0.9495700047635982 1.3209944925866248 0.1865032005817839 1.0 0.7568153455261143 3 P10619 1 Signal amplification 0.7218176912737085 1.3049149704471206 0.1919218030081722 1.0 0.7626366382693158 5 P04899,Q14344,Q16539 3 Transcriptional regulation by mecp2 0.6186430673811659 1.2943946369588937 0.1955291421760927 1.0 0.7658413849686875 10 Q14739 1 Amino acid transport across the plasma membrane 0.9393575593589948 1.2861819521277424 0.1983795681963394 1.0 0.7667977809358013 3 P08195 1 Degradation of the extracellular matrix 0.6817453471364278 1.2786233019557007 0.2010297402356939 1.0 0.7667977809358013 7 P35613,Q92542 2 Fcgamma receptor fcgr dependent phagocytosis 0.5071718649088575 1.2767229613290985 0.20170007206212 1.0 0.7667977809358013 23 Q8IV08 1 Tgf beta receptor signaling activates smads 0.6252359413597213 1.275591741051462 0.2020998751354192 1.0 0.7667977809358013 9 Q9Y4E8,P62942 2 Glycerophospholipid biosynthesis 0.5023267369610591 1.2742651986770128 0.2025694456645697 1.0 0.7667977809358013 27 Q96N66,P35790,Q8NCC3,P48651,Q8IV08 5 Vitamin d calciferol metabolism 0.9237039568810728 1.2329182015459168 0.2176062838884154 1.0 0.7907137427923973 3 Q99538 1 Phospholipid metabolism 0.4988642529152565 1.2064390242222394 0.2276482567500279 1.0 0.81272097290043 37 Q10713,Q96N66,P35790,Q8NCC3,P48651,Q8IV08 6 O linked glycosylation 0.914683266202856 1.2022924937572406 0.2292502241220662 1.0 0.81272097290043 3 Q86SF2,O43505 2 O linked glycosylation of mucins 0.914683266202856 1.2022924937572406 0.2292502241220662 1.0 0.81272097290043 3 Q86SF2,O43505 2 Defective intrinsic pathway for apoptosis 0.5839497804960168 1.1988601723567531 0.2305823204978188 1.0 0.81272097290043 12 P05067,P04632 2 Intrinsic pathway of fibrin clot formation 0.8799414348462722 1.1905527426882851 0.2338292129536925 1.0 0.81272097290043 2 P42785 1 Formation of fibrin clot clotting cascade 0.8799414348462722 1.1905527426882851 0.2338292129536925 1.0 0.81272097290043 2 P42785 1 Signaling by notch1 pest domain mutants in cancer 0.6899458987501823 1.1834554292083894 0.2366287007905052 1.0 0.814017300071214 5 Q92542 1 Metabolism of nitric oxide nos3 activation and regulation 0.6650225235277175 1.174709042962541 0.2401111402630742 1.0 0.814017300071214 6 O94760 1 Regulation of cholesterol biosynthesis by srebp srebf 0.4908532707460192 1.1683356739779476 0.2426713909347078 1.0 0.8203741798016614 22 Q9UBM7,Q16850,O95487,P48449,Q86X55,Q13907,P37268 7 Rho gtpases activate nadph oxidases 0.6844390248906331 1.16249353139204 0.245035050708259 1.0 0.8226911680286273 5 Q13526,Q16539,P28482 3 Activated notch1 transmits signal to the nucleus 0.8722547584187464 1.1615160828912918 0.2454320865988861 1.0 0.8226911680286273 2 Q92542 1 Cargo recognition for clathrin mediated endocytosis 0.4805129342129909 1.15675743722269 0.2473714757669003 1.0 0.8226911680286273 30 P11717,Q14108,P02786 3 Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.8997644338754069 1.1517825985140573 0.2494104203295029 1.0 0.8226911680286273 3 Q9Y624 1 Platelet activation signaling and aggregation 0.5087438876482195 1.1465955342523655 0.2515488230027205 1.0 0.8257363537697999 48 P05067,P13473,P07602,O43852,Q9UEU0,Q08380 6 Mitophagy 0.5668453446461503 1.1168621340523992 0.2640532771532853 1.0 0.84473375439794 12 Q9NS69,Q8N4H5 2 Synthesis of ketone bodies 0.7205623679590808 1.1078894866585036 0.2679095465673755 1.0 0.84473375439794 4 P35610 1 Ketone body metabolism 0.7205623679590808 1.1078894866585036 0.2679095465673755 1.0 0.84473375439794 4 P35610 1 Transport of inorganic cations anions and amino acids oligopeptides 0.635164240487001 1.0931975540691443 0.2743070707326216 1.0 0.8471163987694483 7 P08195,P30825 2 Tryptophan catabolism 0.8535871156661845 1.091368249522963 0.2751108774585915 1.0 0.8471163987694483 2 P08195 1 Pexophagy 0.8466325036603262 1.0653900240028014 0.2866994693119116 1.0 0.8525701942995358 2 Q13501 1 Ros and rns production in phagocytes 0.5770332627290977 1.0626935107095057 0.2879209646701768 1.0 0.8536955817301354 9 Q93050 1 Interferon gamma signaling 0.5610172342469941 1.0581518696243364 0.2899862100196988 1.0 0.8567201291668929 11 P10321,P04439,P01889 3 E2f enabled inhibition of pre replication complex formation 0.8667006365022094 1.040681133600584 0.2980235621529341 1.0 0.8709978945501881 3 Q9Y619 1 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.5533372372579286 1.0223613676390129 0.3066098979733829 1.0 0.8764936980491875 11 P05067 1 Gpvi mediated activation cascade 0.6941388518735818 1.0117767096324355 0.3116448282996846 1.0 0.8798708969172511 4 P84095 1 Toll like receptor cascades 0.464901326250835 1.010896315639135 0.3120660576262803 1.0 0.8798708969172511 24 P05067 1 Diseases associated with glycosylation precursor biosynthesis 0.6224358994470135 1.0087478035152389 0.3130955995018771 1.0 0.8809460035673935 6 P10619 1 Activation of nima kinases nek9 nek6 nek7 0.6879120879120888 0.9892623216742864 0.3225348136105861 1.0 0.8946876081265972 4 P14635,P06493,Q8TD19 3 P75 ntr receptor mediated signalling 0.5054585391404764 0.983208188692748 0.3255049853996339 1.0 0.8946876081265972 15 P52565,Q13501,Q92542,Q14344 4 Rnd2 gtpase cycle 0.5068866850724959 0.9802476265347908 0.3269639003290336 1.0 0.8946876081265972 14 P51648,P02786,Q8TAA9 3 Suppression of apoptosis 0.6823782411077692 0.9693060710022128 0.3323925011277016 1.0 0.8946876081265972 4 P14373,P28482 2 Metabolism of cofactors 0.6329292606957004 0.9675967712983532 0.3332457903867687 1.0 0.8950217967107089 5 O75874 1 Signalling to erks 0.5531983682505069 0.9577516561378868 0.338188002069117 1.0 0.9011715584547648 9 P36507,P11234,P28482,P11233,Q16539,P62993 6 Signal regulatory protein family interactions 0.8147877013177229 0.9477970959888752 0.3432327592063593 1.0 0.9039793018632604 2 Q08722 1 Signal transduction by l1 0.5466912690745264 0.9292189240518244 0.3527756421040564 1.0 0.920195964720562 9 P67870,P36507,P05556,P28482 4 Uptake and function of anthrax toxins 0.6705037422519513 0.9266720410219168 0.3540968382148244 1.0 0.9218728029385944 4 P36507 1 Visual phototransduction 0.5996924197677063 0.9209081157955108 0.3570984010421114 1.0 0.926138792015705 6 P01130 1 Iron uptake and transport 0.4778623080111026 0.9091205756470648 0.3632864827239062 1.0 0.93437537797216 18 Q93050,Q9Y487,P02786,Q15904 4 Rhoa gtpase cycle 0.4647679597530468 0.9046835771097704 0.3656330439686928 1.0 0.9361332505394372 42 P27105,Q15904,P02786,Q14739 4 Syndecan interactions 0.8211182400166487 0.8903604497561832 0.3732723718918609 1.0 0.9361332505394372 3 P05556 1 Non integrin membrane ecm interactions 0.8211182400166487 0.8903604497561832 0.3732723718918609 1.0 0.9361332505394372 3 P05556 1 Formation of the cornified envelope 0.6112858050174256 0.8868322479199606 0.3751692229035615 1.0 0.9361332505394372 5 Q14126 1 Keratinization 0.6112858050174256 0.8868322479199606 0.3751692229035615 1.0 0.9361332505394372 5 Q14126 1 Negative regulators of ddx58 ifih1 signaling 0.5892982068046975 0.8810666952765014 0.3782817221551013 1.0 0.9361332505394372 6 Q13526 1 Nod1 2 signaling pathway 0.6571428571428584 0.8790543136276053 0.3793718274409929 1.0 0.9361332505394372 4 Q14790,Q96J02,Q16539 3 Fatty acid metabolism 0.4726688468295456 0.8615005486588835 0.3889624191134897 1.0 0.9361332505394372 51 P34913,O43772,Q9UMR5,P50897,Q15165,Q9H7Z7,P23786 7 Ercc6 csb and ehmt2 g9a positively regulate rrna expression 0.5294118593776129 0.8538198542973262 0.3932048118789022 1.0 0.9391306491097156 9 Q13185 1 Biological oxidations 0.4530481834629105 0.8486172912428134 0.3960942822035938 1.0 0.9426743525608834 40 Q16850,P05091,Q5VT66,O60701,P48507,O43169,P07099 7 Raf independent mapk1 3 activation 0.5981562272931445 0.8383490528607498 0.4018346938762995 1.0 0.9464356134798806 5 P36507,Q02750,P28482 3 Activation of gene expression by srebf srebp 0.4754454469068456 0.8340019689741963 0.4042798743103655 1.0 0.9476306687543063 16 Q9UBM7,Q16850,P48449,Q86X55,Q13907,P37268 6 Class i peroxisomal membrane protein import 0.5121363997595876 0.8121649864328857 0.4166969675761334 1.0 0.9488283916235688 10 Q9NR77,P51648,Q9Y3D6,Q8TB36 4 Ngf stimulated transcription 0.7748901903367553 0.8046591327176832 0.4210164086657748 1.0 0.95360216562798 2 Q14839 1 Hemostasis 0.4693604643187902 0.7908839605387249 0.4290117089685032 1.0 0.9545285650541274 103 P35613,Q9Y624,P05067,Q9Y6I9,P13473,Q08722,P07602,Q8NBX0,O43852,P42785,P05556,Q9UEU0,P08195,Q08380,Q92896 15 P38mapk events 0.789088246063713 0.7876357116863485 0.4309098195746808 1.0 0.9545285650541274 3 P11233,Q16539 2 Dna replication initiation 0.5571696355660325 0.7869637981921045 0.4313030586620012 1.0 0.9545285650541274 7 Q14181 1 Leishmania infection 0.4250643264533891 0.779809307142104 0.4355031272532375 1.0 0.9545285650541274 30 P05067,Q9UQB8 2 Activation of the pre replicative complex 0.4549847661199677 0.7788202622517572 0.4360856001089694 1.0 0.9545285650541274 18 Q14181,Q9NRF9,Q9Y619 3 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.4673661774361934 0.774371016574685 0.4387114181900977 1.0 0.9545285650541274 14 P10619 1 Response of eif2ak4 gcn2 to amino acid deficiency 0.4791944043530252 0.7723950686887981 0.439880473671699 1.0 0.9549481848559728 74 P62861,P62249,P47914,P08708,P61927,P30050,P39023,P49207,P63173,P61313,P62277,P62266,P62857,P25398,P60866,P62917,P40429,P36578,P32969,P62851,Q02543,P62280,P62244,P62241,P46779,P46776,P18621,P23396,P26373,P62888,P27635,P62841,P35268,P83731,P62701,P46777,P46778,P18077,P62910,Q02878,Q07020,P62899,P20042,P83881,Q9Y3U8,P15880,P62753,P62424,P46782,P46781 50 Mapk1 erk2 activation 0.763543191800887 0.7650541595177888 0.444239294911259 1.0 0.956197550207732 2 P36507 1 Thrombin signalling through proteinase activated receptors pars 0.7635431918008856 0.765054159517785 0.4442392949112612 1.0 0.956197550207732 2 Q14344 1 Signal attenuation 0.763543191800879 0.7650541595177605 0.4442392949112759 1.0 0.956197550207732 2 P62993 1 Activation of the ap 1 family of transcription factors 0.7635431918008783 0.7650541595177581 0.4442392949112772 1.0 0.956197550207732 2 Q16539 1 Formation of apoptosome 0.7635431918008766 0.7650541595177534 0.4442392949112801 1.0 0.956197550207732 2 Q9NR28 1 Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.6228006191892365 0.7588605463071829 0.4479359822579736 1.0 0.9566487374800464 4 O14654,P62993 2 Insulin receptor signalling cascade 0.6177799900607804 0.7416116862237634 0.4583226410296741 1.0 0.9656751459834528 4 P62993,P28482 2 Downregulation of tgf beta receptor signaling 0.544763182886092 0.7394962387024269 0.4596057228568744 1.0 0.966879531520886 7 Q9Y4E8,P62140 2 Glutathione synthesis and recycling 0.567604879221162 0.7275318029546373 0.4669002403986582 1.0 0.9713230275663516 5 P48507 1 Synthesis of substrates in n glycan biosythesis 0.489212030626882 0.7274087071446264 0.4669756221451244 1.0 0.9713230275663516 11 P10619 1 Arachidonic acid metabolism 0.5183681287763579 0.716615705491552 0.4736112509876611 1.0 0.9713230275663516 8 Q15165,P34913 2 Eukaryotic translation elongation 0.471911518224804 0.7149031686866436 0.4746688789029525 1.0 0.9713230275663516 75 P62861,P62249,P47914,P08708,P61927,P24534,P39023,P30050,P49207,P63173,P61313,P62277,P62266,P62857,P25398,P60866,P62917,P40429,P36578,P32969,P62851,Q02543,P62280,P62244,P62241,P46779,P46776,Q05639,P18621,P23396,P26373,P62888,P27635,P62841,P35268,P83731,P62701,P46777,P46778,P18077,P26641,P62910,Q02878,Q07020,P62899,P83881,Q9Y3U8,P15880,P62753,P62424,P46782,P46781 52 P75ntr regulates axonogenesis 0.7616257781032589 0.7021612482668705 0.4825786094117976 1.0 0.9771724399085993 3 P52565,Q9NQC3 2 Recycling of eif2 gdp 0.5342415497145101 0.6996659685586591 0.4841359340952715 1.0 0.9771724399085993 7 Q13144,P49770,Q9NR50 3 Uptake and actions of bacterial toxins 0.4924853863608386 0.6954255945309387 0.4867886253260645 1.0 0.9771724399085993 9 P36507,Q7L0J3 2 Regulation of lipid metabolism by pparalpha 0.4701212244097807 0.6600583716134812 0.5092163713883693 1.0 0.995719494556538 12 P23786,P37268 2 Bmal1 clock npas2 activates circadian gene expression 0.7370926400585867 0.6283358767436856 0.5297839338546322 1.0 1.0 3 Q86X55,P43490 2 Processing of intronless pre mrnas 0.4379192843307996 0.6246005362166486 0.5322332676654149 1.0 1.0 14 Q5KU26 1 Neurexins and neuroligins 0.4903087033526991 0.6060822772597424 0.5444601189920715 1.0 1.0 8 O14936 1 Vesicle mediated transport 0.3474867923710839 0.590751549726541 0.5546869024701251 1.0 1.0 220 O75976,P53634,P05067,O00461,P01130,Q9UIQ6,Q5KU26,Q14108,Q99523,P02786,P15586,P11717,O15260,Q8WTV0 14 Negative feedback regulation of mapk pathway 0.7206151592823145 0.5803299823524213 0.5616921122323864 1.0 1.0 3 P36507,P28482 2 Platelet sensitization by ldl 0.5661026730315503 0.570549876125216 0.5683048038258831 1.0 1.0 4 Q14738,Q16539 2 Mapk3 erk1 activation 0.7035139092240099 0.5666128227146994 0.5709772611974318 1.0 1.0 2 Q02750 1 Mhc class ii antigen presentation 0.427074031217232 0.532526811373836 0.5943611773459252 1.0 1.0 52 P53634,Q99538,P10619 3 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.5534798534798551 0.5309651197877113 0.5954429502492475 1.0 1.0 4 P30153,Q14738,P17612 3 Cd28 co stimulation 0.4690892877525724 0.5253655933459248 0.5993290670744962 1.0 1.0 8 P62993,P42345 2 Potential therapeutics for sars 0.3818437512929821 0.4970108100072132 0.6191814282981081 1.0 1.0 31 P05556,Q99720,P62942 3 Phosphorylation of emi1 0.6876601977297694 0.4887845238425408 0.6249942558057722 1.0 1.0 3 P14635,P06493 2 Rnd3 gtpase cycle 0.4091873148671598 0.486017642232311 0.6269546575226588 1.0 1.0 16 O75976,Q8TAA9 2 Class i mhc mediated antigen processing presentation 0.4350750347773951 0.4841144384443202 0.6283046549280673 1.0 1.0 102 Q8NEZ5,Q9UIQ6,Q9UJX4,P25788,Q05086,P04439,P20618,P63208,P49721,O95487,Q9UBG0,Q8TBC4,P10321,P01889,P28072,P60900,Q9NZ08,Q96J02 18 Processing of capped intronless pre mrna 0.4084165010943393 0.4821587514087264 0.6296931765462168 1.0 1.0 16 Q5KU26 1 Dna damage reversal 0.6832662028560967 0.4770785704006042 0.633306173763283 1.0 1.0 3 Q6P6C2,Q8N3C0 2 Mtorc1 mediated signalling 0.4345525583665607 0.4605427224999633 0.6451267134705891 1.0 1.0 9 P42345,Q6IAA8,P06730,P62942 4 Intra golgi traffic 0.4335711171964217 0.4567739593699792 0.6478335247937115 1.0 1.0 9 O00461 1 Interconversion of nucleotide di and triphosphates 0.3957438338338591 0.4541549246257787 0.6497173234941096 1.0 1.0 18 P15531,P00390,Q9NRF8,Q9Y3D8,P32321,Q9H773,P22392 7 Interleukin 1 signaling 0.4060024831148877 0.4541064071675518 0.6497522419325943 1.0 1.0 46 P05067,P20618,P63208,P49721,Q13501,P28072,P60900 7 Negative regulation of fgfr1 signaling 0.6664670058468681 0.4335198292722174 0.6646371635715864 1.0 1.0 3 P62993 1 Negative regulation of fgfr3 signaling 0.6664670058468681 0.4335198292722174 0.6646371635715864 1.0 1.0 3 P62993 1 Spry regulation of fgf signaling 0.6664670058468681 0.4335198292722174 0.6646371635715864 1.0 1.0 3 P62993 1 Negative regulation of fgfr2 signaling 0.6664670058468681 0.4335198292722174 0.6646371635715864 1.0 1.0 3 P62993 1 Negative regulation of fgfr4 signaling 0.6664670058468681 0.4335198292722174 0.6646371635715864 1.0 1.0 3 P62993 1 Miro gtpase cycle 0.5183150183150199 0.4265565975054344 0.6697023161893916 1.0 1.0 4 Q8IXI2,Q8IWA4,O95140 3 Clathrin mediated endocytosis 0.4049473140076282 0.4249085973508464 0.6709033070794082 1.0 1.0 48 P11717,Q14108,P02786 3 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.4407609241505325 0.4227029943933634 0.6725119706057163 1.0 1.0 8 P12004,P14635,Q99873,Q86X55 4 Cdt1 association with the cdc6 orc origin complex 0.3856143889090535 0.4203813346381851 0.6742069013921768 1.0 1.0 38 P28072,P49721,Q9Y619 3 Cross presentation of soluble exogenous antigens endosomes 0.3835951076532539 0.4073994272178173 0.6837146475908971 1.0 1.0 38 P28072,P49721,Q9UBG0 3 Beta oxidation of very long chain fatty acids 0.5094253138029532 0.4017141182320754 0.6878944329954628 1.0 1.0 4 O14734 1 Activated tak1 mediates p38 mapk activation 0.6525082387403881 0.3988537513118386 0.6900009685004194 1.0 1.0 3 P61088,Q16539 2 Transcriptional activation of mitochondrial biogenesis 0.4110579439312565 0.3888557320482481 0.6973828706510468 1.0 1.0 10 P00367 1 Autophagy 0.3922626422670324 0.3875118575967043 0.6983773082566409 1.0 1.0 44 O96008,Q8N4H5,P50542,P13473,Q96FJ2,Q13501,Q9NS69,O95352 8 Circadian clock 0.410636676176602 0.3872611655686662 0.6985628722307136 1.0 1.0 10 Q86X55,P62140 2 Cytochrome c mediated apoptotic response 0.5032114720977893 0.38476084392685 0.7004146118983579 1.0 1.0 4 Q9NR28,P55210 2 Apoptotic cleavage of cellular proteins 0.3736309560959951 0.3714894998681644 0.7102729752274017 1.0 1.0 19 Q14126,Q16625 2 Ctla4 inhibitory signaling 0.4926739926739943 0.3568224895086496 0.7212246989008122 1.0 1.0 4 P30153,Q14738,P30154 3 Adora2b mediated anti inflammatory cytokines production 0.4349859434880797 0.355139947928258 0.7224847505682117 1.0 1.0 7 P04899,P10644 2 Gaba receptor activation 0.6322802279066402 0.3512734308470742 0.7253832255845123 1.0 1.0 3 P04899 1 Gaba b receptor activation 0.6322802279066402 0.3512734308470742 0.7253832255845123 1.0 1.0 3 P04899 1 Adenylate cyclase inhibitory pathway 0.6322802279066402 0.3512734308470742 0.7253832255845123 1.0 1.0 3 P04899 1 G alpha z signalling events 0.6322802279066402 0.3512734308470742 0.7253832255845123 1.0 1.0 3 P04899 1 Adp signalling through p2y purinoceptor 12 0.6322802279066402 0.3512734308470742 0.7253832255845123 1.0 1.0 3 P04899 1 Condensation of prophase chromosomes 0.40255558736905 0.3425721916994876 0.731920325310756 1.0 1.0 9 Q9UPP1 1 Collagen biosynthesis and modifying enzymes 0.3969805498497559 0.339792371661249 0.7340128930167245 1.0 1.0 11 Q32P28,P13674 2 Selective autophagy 0.3543083236776325 0.322465050002958 0.7471004108655577 1.0 1.0 31 Q9NS69,Q8N4H5,Q13501 3 Plasma lipoprotein assembly 0.6138360175695506 0.3201604474792726 0.7488467046912615 1.0 1.0 2 P07237 1 Sensory perception 0.3510861480930971 0.3198609745257693 0.7490737226946464 1.0 1.0 21 P53582,P01130,O14936 3 Aryl hydrocarbon receptor signalling 0.6151592823141707 0.3136263770483772 0.7538048236269619 1.0 1.0 3 O00170,Q15185 2 Cell cell communication 0.3515513033634076 0.3117595640371737 0.7552232566739576 1.0 1.0 24 Q08722,P05556,Q9Y624 3 Interleukin 1 family signaling 0.385468431542539 0.3100641589621494 0.7565121669845838 1.0 1.0 47 P05067,P20618,P63208,P49721,Q13501,P28072,P60900 7 Cd28 dependent vav1 pathway 0.4193455508357036 0.3012407352908438 0.763230929333989 1.0 1.0 6 P62993 1 Met promotes cell motility 0.4164594561144183 0.2934075258225997 0.7692106736900282 1.0 1.0 6 P05556 1 Apoptotic factor mediated response 0.4152461007964277 0.2901434086211361 0.7717065281096773 1.0 1.0 6 Q9NR28,Q07021,P55210 3 Galactose catabolism 0.5885797950219676 0.2650607326135702 0.7909626765198725 1.0 1.0 2 P51570 1 Rhod gtpase cycle 0.3420636719516022 0.2599134587695706 0.7949305293740714 1.0 1.0 24 Q14739 1 Srp dependent cotranslational protein targeting to membrane 0.4129516851576974 0.2596846066330481 0.7951070675204104 1.0 1.0 87 P62861,P47914,P08708,P62249,P61927,P15880,P39023,P30050,P49207,P63173,P61313,P62277,P46782,P62266,P62857,P25398,P60866,P40429,P62917,P36578,P32969,P62851,Q02543,P62280,P49458,P62244,P62241,P46776,P46779,O76094,P23396,P18621,P26373,P62888,P27635,P62841,P35268,P83731,P62701,P46777,P46778,P43307,P18077,P62910,Q02878,Q07020,Q15629,P83881,Q9Y3U8,P62899,P62753,P62424,P67812,P46781 54 Membrane trafficking 0.3220353663301013 0.2582293447585201 0.7962299118817866 1.0 1.0 213 O75976,P53634,P05067,O00461,P01130,Q9UIQ6,Q14108,Q99523,P02786,P15586,P11717,O15260 12 Raf activation 0.3742203006209191 0.2576830468078662 0.7966515310494753 1.0 1.0 10 P36507 1 Rhov gtpase cycle 0.3597631360549947 0.257301314253493 0.7969461779741855 1.0 1.0 15 Q8TAA9 1 Regulation of insulin secretion 0.3732085669924987 0.2540809872585742 0.7994329914611777 1.0 1.0 11 P11166,P10644 2 Signaling by notch4 0.366965537392924 0.2530679089442884 0.8002157368095397 1.0 1.0 42 P25788,P28072,P20618,P63208,Q92542,P49721,P49720,P60900 8 Prolonged erk activation events 0.4092544678690249 0.2457143815411641 0.8059033385902266 1.0 1.0 5 P36507,P28482 2 Metabolism of steroid hormones 0.3963627710893251 0.2447412954151617 0.8066567510687697 1.0 1.0 7 O95772,Q14849,Q53GQ0 3 Sumoylation of transcription cofactors 0.3831513348973047 0.2387792310516702 0.8112767756754924 1.0 1.0 8 Q15424,P06748,Q13363 3 Irs mediated signalling 0.5762552562962032 0.2377585509528373 0.812068368399238 1.0 1.0 3 P62993 1 Dcc mediated attractive signaling 0.5721083455344136 0.2329865139331425 0.815771877954222 1.0 1.0 2 P63000 1 Erks are inactivated 0.3997801392451382 0.2246727480947651 0.8222338664938398 1.0 1.0 5 P30153,Q14738,P30154,P28482 4 Regulation of tp53 activity through acetylation 0.3601367652518217 0.2125751048024269 0.8316583911206583 1.0 1.0 10 Q14839 1 Cilium assembly 0.3832985208879888 0.2087679903292759 0.8346293607255559 1.0 1.0 56 O43924,A6NIH7 2 Negative regulation of mapk pathway 0.3585697883116857 0.2077501908328181 0.8354240259312777 1.0 1.0 10 P36507,P30086,P28482 3 Nonsense mediated decay nmd 0.4050379087494526 0.206527688442865 0.8363787386660235 1.0 1.0 83 P62861,P47914,P08708,P62249,P61927,P15880,P39023,Q9NPI6,P49207,P30050,P61313,P63173,P62277,P62266,P62857,P25398,P60866,P40429,P62917,P36578,P32969,P15170,P62851,Q02543,P62280,P62244,P62241,P46776,P46779,P23396,P18621,P26373,P62888,P63151,P27635,P62841,P35268,P83731,P62701,P46777,P46778,P18077,P62910,Q02878,Q07020,P83881,Q9Y5S9,Q9Y3U8,P62899,P62753,P62424,P46782,P46781 53 Pp2a mediated dephosphorylation of key metabolic factors 0.553277187843281 0.1996184263038324 0.8417790157140854 1.0 1.0 3 P30153,Q14738 2 Metabolism of carbohydrates 0.4033124077690558 0.191063520339031 0.8484758276440125 1.0 1.0 91 P10253,P07686,Q96L58,O43505,P54802,P16278,P15586,P06865,P08236 9 Cell junction organization 0.3409929378227446 0.1816228042779733 0.8558787512703012 1.0 1.0 15 Q9Y624 1 Mtor signalling 0.350645957520149 0.1806882138681012 0.8566123104839956 1.0 1.0 11 P42345,Q6IAA8,P06730,P62942 4 Regulation of pten gene transcription 0.3336875035466923 0.1622519133059918 0.8711074804453751 1.0 1.0 14 Q6IAA8,Q15022,Q14839,P42345 4 G alpha s signalling events 0.3923011552907935 0.1507528223538913 0.88017070313261 1.0 1.0 4 P04899 1 Rhot1 gtpase cycle 0.5179355783309028 0.1495531350009039 0.8811171850756816 1.0 1.0 2 Q8IXI2 1 Sema3a pak dependent axon repulsion 0.3538687202053516 0.145388680315114 0.8844040015042884 1.0 1.0 7 Q13177,Q13153,P63000,P23528,P07900,P08238 6 G protein beta gamma signalling 0.3536093807255362 0.1389395469186395 0.8894979201022934 1.0 1.0 5 P60953,P31751,P61586,Q13153 4 Protein localization 0.3866179072040379 0.1371027490915669 0.8909495795299791 1.0 1.0 69 P05067,P34913,P51648,Q99595,Q10713,O60830,Q9NS69,P62072,Q5JRX3 9 Scavenging by class f receptors 0.3765567765567786 0.1292517835778563 0.8971584224428004 1.0 1.0 4 P27797,P07900,Q9Y4L1 3 Loss of function of mecp2 in rett syndrome 0.4937774524158148 0.1229358849709687 0.9021578690464828 1.0 1.0 2 P17612 1 Smac xiap regulated apoptotic response 0.4855936505889175 0.1165747879073881 0.907197017811564 1.0 1.0 3 P55210 1 Ca2 pathway 0.482430453879951 0.1125161635584638 0.9104141544553528 1.0 1.0 2 P35222 1 Fructose metabolism 0.4763822775540096 0.1085047444295298 0.9135953172258112 1.0 1.0 3 P15121,Q00796 2 Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0.4721815519765813 0.1041741925072676 0.9170311139168564 1.0 1.0 2 Q92769 1 Dscam interactions 0.3534798534798556 0.1030190604239277 0.9179478434086396 1.0 1.0 4 P63000,Q13153,Q16539 3 Ephrin signaling 0.3534798534798556 0.1030190604239277 0.9179478434086396 1.0 1.0 4 P63000,Q13177,Q13153 3 Golgi cisternae pericentriolar stack reorganization 0.3253571494334543 0.099938446658928 0.920393193107398 1.0 1.0 8 P14635,P06493,P28482 3 Processing and activation of sumo 0.4557101024890189 0.0927487946096641 0.9261031315546382 1.0 1.0 2 Q9UBT2 1 Sumo is conjugated to e1 uba2 sae1 0.4557101024890189 0.0927487946096641 0.9261031315546382 1.0 1.0 2 Q9UBT2 1 Sumo is transferred from e1 to e2 ube2i ubc9 0.4557101024890189 0.0927487946096641 0.9261031315546382 1.0 1.0 2 Q9UBT2 1 Rap1 signalling 0.4511168070303918 0.0899321915858358 0.928341099605596 1.0 1.0 3 P17612,P63104 2 Constitutive signaling by aberrant pi3k in cancer 0.3116274879492317 0.0855940207652027 0.9317891517549376 1.0 1.0 5 P84095 1 Signaling by mapk mutants 0.4121522693997059 0.0725103312415188 0.9421957839711406 1.0 1.0 2 P28482 1 Wnt mediated activation of dvl 0.4000732064421661 0.068962935750251 0.9450191222164634 1.0 1.0 2 P67870 1 Rna polymerase i transcription 0.3066911908833192 0.0682879033441607 0.9455564533836488 1.0 1.0 19 Q13185 1 Synthesis of diphthamide eef2 0.4042475283778838 0.0673845464992687 0.9462755713319744 1.0 1.0 3 Q9H2P9,Q9BQC3 2 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.3865300146412961 0.0658068384041786 0.9475316117810249 1.0 1.0 2 P24941 1 Met activates ras signaling 0.2946741711849603 0.0613280624330988 0.9510979422698967 1.0 1.0 4 P62993,Q96S59 2 Scf skp2 mediated degradation of p27 p21 0.3304957580857556 0.0600830428678032 0.9520894953927744 1.0 1.0 41 P25788,P28072,P20618,P11802,P63208,P49721,P49720,P60900 8 Translation of replicase and assembly of the replication transcription complex 0.2912087912087935 0.0598187265489903 0.9523000106546348 1.0 1.0 4 Q9UQN3,Q8NEB9,Q96FZ7 3 Erbb2 regulates cell motility 0.3177159590043831 0.0585273714788719 0.9533285605711492 1.0 1.0 2 P61586 1 Runx2 regulates bone development 0.3081991215226846 0.0581958817413615 0.9535926010590036 1.0 1.0 2 P28482 1 Constitutive signaling by overexpressed erbb2 0.3690955693885026 0.0581889373666361 0.9535981324947412 1.0 1.0 3 P62993,P07900 2 G beta gamma signalling through cdc42 0.3533504210911754 0.0555896886213281 0.9556686790917754 1.0 1.0 3 P60953,Q13153 2 Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 0.3423654339069939 0.0541997411575643 0.956776026909445 1.0 1.0 3 P06748,P46087 2 Response of eif2ak1 hri to heme deficiency 0.3419992676675212 0.0541586500742625 0.9568087647660076 1.0 1.0 3 P05198,P20042 2 Dna methylation 0.2648351648351671 0.0509654467049329 0.9593530542837688 1.0 1.0 4 Q96T88,P26358,P16104 3 Eukaryotic translation initiation 0.3813758992083738 0.0470164728506077 0.9625000986109752 1.0 1.0 99 P62861,P47914,P08708,P62249,P61927,P15880,P39023,P30050,P49207,P63173,P61313,P62277,P62266,P62857,P25398,P60866,Q15056,Q9UI10,P40429,P62917,P55010,P36578,O00303,P06730,Q13347,P32969,Q9NR50,P62851,Q02543,P62280,P62244,P62241,Q13144,P46776,P46779,P23396,P18621,P26373,P62888,P27635,P62841,P35268,P83731,P62701,P46777,P46778,P18077,P62910,Q02878,Q07020,P20042,P83881,P49770,Q9Y3U8,P62899,P62753,P62424,P46782,P46781 59 Gap junction degradation 0.2491755221692881 0.0439928506825732 0.964910102680672 1.0 1.0 5 P50570,Q96CW1,Q9UM54,P09496 4 Budding and maturation of hiv virion 0.2916360968451941 0.0438986989287069 0.964985152407243 1.0 1.0 8 O75351,Q9UQN3,Q9NZZ3,Q8WUM4,Q99816,Q9NP79,Q96FZ7 7 E3 ubiquitin ligases ubiquitinate target proteins 0.3029798804471024 0.0423973669965564 0.9661819272961024 1.0 1.0 16 P50542,P12004,Q14527,P04439,Q9BUN8,Q6PD62 6 Hiv transcription initiation 0.2973171628077968 0.0385530774323387 0.9692467132395264 1.0 1.0 13 P24928,P35269,P18074,P62875,P19388,P19387,P62487,Q92804,P19447,P29083,P30876,P13984 12 Cyclin a cdk2 associated events at s phase entry 0.3278714311069558 0.0361973961844271 0.9711249621743908 1.0 1.0 42 P25788,P28072,P20618,P11802,P63208,P49721,P49720,P60900 8 Mrna decay by 5 to 3 exoribonuclease 0.2544607892485372 0.0321466207681679 0.97435512460786 1.0 1.0 6 Q9NPI6 1 Orc1 removal from chromatin 0.3375930922343771 0.0252164115073148 0.9798823466287412 1.0 1.0 48 P20618,P63208,Q9Y619,P49721,P28072,P60900 6 Cyclin d associated events in g1 0.2778399798212616 0.0235857920438078 0.9811830053064772 1.0 1.0 9 P63208 1 Ksrp khsrp binds and destabilizes mrna 0.2860798287532025 0.0227872523611657 0.9818199765279296 1.0 1.0 11 O95453,Q9NQT5,Q15024,Q16539 4 Telomere extension by telomerase 0.2726605504587251 0.0162439321671817 0.9870397872780556 1.0 1.0 9 O00743,Q9NYB0,Q9Y265,Q9NY12,Q9NPE3,P24941,Q9NX24,O60832 8 Mitochondrial fatty acid beta oxidation 0.2894118294228499 0.0137665546693192 0.98901622551221 1.0 1.0 15 P40939,Q8IVS2 2 Cellular response to starvation 0.3765375668613053 0.0128008303414448 0.9897866940333924 1.0 1.0 86 P62861,P47914,P08708,P62249,P61927,P15880,P39023,P30050,P49207,P63173,P61313,P62277,P62266,P62857,P25398,P60866,P42345,P40429,P62917,P36578,P32969,P62851,Q02543,P62280,P62244,P62241,P46776,P46779,P23396,P18621,P26373,P62888,P27635,P62841,Q6IAA8,P35268,P83731,P62701,P46777,P46778,P18077,P62910,Q02878,Q07020,P20042,P83881,Q9Y3U8,P62899,P62753,P62424,P46782,P46781 52 Inhibition of dna recombination at telomere 0.2653211009174387 0.0066443933926444 0.9946985801039524 1.0 1.0 9 P24928,Q9NYB0,P62875,P19388,P19387,P62487,P16104,P30876 8 Activation of bh3 only proteins 0.2724935732647862 0.0002005871767838 0.9998399545896224 1.0 1.0 11 P31751,P04637,Q96FJ2,P63167,P63104,P27348,P62258,Q04917,P31946,P61981 10